PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25251220-4 2014 We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. 3-hydroxypicolinic acid 14-17 aquaporin 4 Homo sapiens 250-261 25251220-4 2014 We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. 3-hydroxypicolinic acid 14-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 263-268 25251220-4 2014 We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. 3-hydroxypicolinic acid 14-17 matrix metallopeptidase 2 Homo sapiens 270-275 25251220-4 2014 We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. 3-hydroxypicolinic acid 14-17 matrix metallopeptidase 9 Homo sapiens 281-286 17240976-6 2006 A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. 3-hydroxypicolinic acid 23-44 phosphatase and tensin homolog Homo sapiens 103-107 17240976-6 2006 A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. 3-hydroxypicolinic acid 23-44 AKT serine/threonine kinase 1 Homo sapiens 175-178 12169606-7 2002 These results, together with the observed recovery of the defect in VS production by the external addition of 3-hydroxypicolinic acid (3-HPA), a starter molecule in VS biosynthesis, suggest that VisA is the first enzyme of the VS biosynthetic pathway and that it supplies 3-HPA from L-lysine. 3-hydroxypicolinic acid 110-133 mitochondrial antiviral signaling protein Rattus norvegicus 195-199 35587699-1 2022 Homoleptic fac-Ir(ppz)3 (ppz = phenylpyrazole) and a series of heteroleptic Ir(ppz)2(LX) complexes consisting of picolinic acid (pic), 3-hydroxypicolinic acid (picOH), and isoquinolinecarboxylic acid (iq) as ancillary ligands (LX) were synthesised to investigate the influence of the ancillary ligands on the photophysical properties of the complexes. 3-hydroxypicolinic acid 135-158 insulin receptor Homo sapiens 76-84 12169606-7 2002 These results, together with the observed recovery of the defect in VS production by the external addition of 3-hydroxypicolinic acid (3-HPA), a starter molecule in VS biosynthesis, suggest that VisA is the first enzyme of the VS biosynthetic pathway and that it supplies 3-HPA from L-lysine. 3-hydroxypicolinic acid 135-140 mitochondrial antiviral signaling protein Rattus norvegicus 195-199 12169606-7 2002 These results, together with the observed recovery of the defect in VS production by the external addition of 3-hydroxypicolinic acid (3-HPA), a starter molecule in VS biosynthesis, suggest that VisA is the first enzyme of the VS biosynthetic pathway and that it supplies 3-HPA from L-lysine. 3-hydroxypicolinic acid 272-277 mitochondrial antiviral signaling protein Rattus norvegicus 195-199