PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32013623-1	2020	Purpose: To assess the associations between preeclampsia, methylenetetrahydrofolate reductase (MTHFR) C677T, and reduced folate carrier-1 (RFC-1) G80A gene polymorphism in Sudanese women.Methods: A matched (for age and parity) case-control study was conducted in a tertiary hospital (Saad Abualila) in Khartoum, Sudan during February to September 2018.	1-phenylazo-2-naphthol	172-177	methylenetetrahydrofolate reductase	Homo sapiens	58-93
25658126-15	2014	Sudan I was also found to be a strong inducer of CYP1A1 and its enzyme activity mediated by the aryl hydrocarbon receptor, thereby increasing its own genotoxic potential and the cancer risk for humans.	1-phenylazo-2-naphthol	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
25658126-15	2014	Sudan I was also found to be a strong inducer of CYP1A1 and its enzyme activity mediated by the aryl hydrocarbon receptor, thereby increasing its own genotoxic potential and the cancer risk for humans.	1-phenylazo-2-naphthol	0-7	aryl hydrocarbon receptor	Homo sapiens	96-121
21217854-0	2009	Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study.	1-phenylazo-2-naphthol	47-80	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	106-126
21217854-9	2009	Metabolic activation of Sudan I by both types of enzymes leads to formation of reactive species (the benzenediazonium ion by CYP and Sudan I radicals by peroxidase) that bind to DNA and RNA, generating covalent adducts in vitro and in vivo.	1-phenylazo-2-naphthol	24-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	125-128
15766589-0	2005	Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers.	1-phenylazo-2-naphthol	100-122	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-33
15766589-3	2005	In the present work, we clearly demonstrate that CYP1A1 capable of metabolizing a carcinogen 1-phenylazo-2-naphthol (Sudan I) is expressed in livers of eight American Caucasian donors.	1-phenylazo-2-naphthol	93-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
15712518-0	2004	Determination of 1-phenylazo-2-naphthol (Sudan I) in chilli powder and in chilli-containing food products by GPC clean-up and HPLC with LC/MS confirmation.	1-phenylazo-2-naphthol	17-39	glycophorin C (Gerbich blood group)	Homo sapiens	109-112
12384524-0	2002	Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.	1-phenylazo-2-naphthol	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-141
12384524-13	2002	On the basis of these studies, we attribute most of Sudan I metabolism in human microsomes to CYP1A1, but participation of CYP3A4 cannot be ruled out.	1-phenylazo-2-naphthol	52-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-100
6506770-1	1984	Lipophilic azo compounds possessing 1-phenylazo-2-naphthol or 1-phenylazo-2-naphthylamine moieties induced cytochrome P-448 and related mono-oxygenase activities, UDP-glucuronyltransferase activity towards p-nitrophenol, glutathione-S-transferase activity towards 1-chloro-2,4-dinitrobenzene, aldehyde dehydrogenase, and menadione reductase activities.	1-phenylazo-2-naphthol	36-58	NAD(P)H quinone dehydrogenase 1	Homo sapiens	321-340
32013623-6	2020	There was borderline significance in the RFC-1 G80A variation, which was present in 2.50% of women with preeclampsia, but was not found in healthy pregnant women (P = 0.052).Conclusions: A higher prevalence of MTHFR C677T polymorphism in women with preeclampsia compared with healthy pregnant women suggests involvement of this variation in preeclampsia in Sudan.	1-phenylazo-2-naphthol	357-362	methylenetetrahydrofolate reductase	Homo sapiens	210-215
31947873-4	2020	In this study, we generated recombinant baculoviruses (rBV) expressing the Sudan virus (SUDV) matrix structural protein (VP40) (rBV-VP40-VP40) or the SUDV glycoprotein (GP) (rBV-GP-GP), and SUDV virus-like particles (VLPs) were produced by co-infection of Sf9 cells with rBV-SUDV-VP40 and rBV-SUDV-GP.	1-phenylazo-2-naphthol	75-80	matrix protein	Sudan ebolavirus	121-125
31798313-0	2018	First season of the UCL - UoK - NCAM Expedition to the Southern Gezira (Sudan): Jebel Moya.	1-phenylazo-2-naphthol	72-77	neural cell adhesion molecule 1	Homo sapiens	32-36
27110040-0	2016	Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).	1-phenylazo-2-naphthol	137-159	cytochrome b5 type A	Rattus norvegicus	33-46
27110040-2	2016	We investigated the influence of exposure to the anticancer drug ellipticine and to two environmental carcinogens, benzo[a]pyrene (BaP) and 1-phenylazo-2-naphthol (Sudan I), on the expression of cytochrome b5 in livers of rats, both at the mRNA and protein levels.	1-phenylazo-2-naphthol	140-162	cytochrome b5 type A	Rattus norvegicus	195-208