PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28523442-2	2017	NAT2 also catalyzes the N-acetylation of aromatic amine carcinogens such as 2-aminofluorene and the O- and N,O-acetylation of aromatic amine and heterocyclic amine metabolites.	2-aminofluorene	76-91	N-acetyltransferase 2	Homo sapiens	0-4
18189370-3	2008	NAT in the film catalyzed the conversion of the arylamine 2-aminofluorene (2-AF) to 2-acetylaminofluorene (2-AAF) by acetyl coenzyme A (AcCoA) dependent N-acetylation, as verified by liquid chromatography.	2-aminofluorene	75-79	bromodomain containing 2	Homo sapiens	0-3
25224404-8	2015	In contrast, the N-acetylated metabolite of 2-aminofluorene was able to significantly activate AhR, whereas the parent AA, 2-aminofluorene, did not.	2-aminofluorene	44-59	aryl hydrocarbon receptor	Homo sapiens	95-98
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	2-aminofluorene	204-219	albumin	Homo sapiens	50-63
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	2-aminofluorene	204-219	albumin	Homo sapiens	286-299
21526848-6	2011	In addition, our data showed that exposure to CB NPs altered the acetylation of 2-aminofluorene in intact lung Clara cells by impairing the endogenous NAT-dependent pathway.	2-aminofluorene	80-95	bromodomain containing 2	Homo sapiens	151-154
18713828-1	2008	Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine.	2-aminofluorene	91-106	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	0-19
18713828-1	2008	Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine.	2-aminofluorene	91-106	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	21-27
20826229-5	2011	Microsomal 2-aminofluorene bio-activation (a CYP4B1 marker) in wallaby lung was comparable to that of rabbit, with significant higher activities detected in wallaby liver and kidneys compared to rabbit.	2-aminofluorene	11-26	cytochrome P450 4B1	Oryctolagus cuniculus	45-51
18613294-12	2008	The ion structure following the 50 m/z unit loss was proposed to be a protonated aminofluorene and was supported by comparing the product ion spectrum of commercially available protonated 2-aminofluorene with the MS4 data of protonated 4-benzenesulfinyl-3-methylphenylamine.	2-aminofluorene	188-203	MS4	Homo sapiens	213-216
16277023-6	2005	MATERIALS AND METHODS: N-Acetylation of 2-aminofluorene (AF) to 2-acetylaminofluorene (AAF) by NAT in the stomach and colon of Sprague-Dawley (SD) rats and in human stomach (SC-M1) and colon (COLO 205) tumor cell lines was investigated.	2-aminofluorene	40-55	N-acetyltransferase 1	Rattus norvegicus	95-98
16829624-9	2006	Recombinant rat Nat3 was functional and catalyzed the N-acetylation of several arylamine substrates, including 3-ethylaniline, 3,5-dimethylaniline, 5-aminosalicylic acid, 4-aminobiphenyl, 4,4"-methylenedianiline, 4,4"-methylenebis(2-chloroaniline), and 2-aminofluorene, and the O-acetylation of N-hydroxy-4-aminobiphenyl.	2-aminofluorene	253-268	N-acetyltransferase 3	Rattus norvegicus	16-20
16829624-10	2006	The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and 2-aminofluorene for N- and O-acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2.	2-aminofluorene	105-120	N-acetyltransferase 3	Rattus norvegicus	166-170
17143337-5	2006	Assuming its abundance and specificity for AAAF induced lesions, TFAM may significantly impede recognition and repair of DNA adducts induced by AAAF and other derivatives of 2-aminofluorene.	2-aminofluorene	174-189	transcription factor A, mitochondrial	Rattus norvegicus	65-69
16314733-6	2005	The results showed that aloe-emodin inhibited NAT1 activity (decreased N-acetylation of 2-aminofluorene) in intact cells in a dose-dependent manner.	2-aminofluorene	88-103	N-acetyltransferase 1	Homo sapiens	46-50
16309210-0	2005	Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells.	2-aminofluorene	37-52	bromodomain containing 2	Homo sapiens	75-94
17936995-1	2007	The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic.	2-aminofluorene	171-186	N-acetyltransferase 2	Homo sapiens	20-24
17936995-1	2007	The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic.	2-aminofluorene	171-186	N-acetyltransferase 2	Homo sapiens	26-47
15833378-4	2005	NAT activity was measured by the amounts of N-acetylation of 2-aminofluorene (AF) and non-acetylation of AF by high performance liquid chromatography on cells treated with or without DADS.	2-aminofluorene	61-76	bromodomain containing 2	Homo sapiens	0-3
12230020-2	2002	The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF).	2-aminofluorene	105-120	bromodomain containing 2	Homo sapiens	4-7
14667466-2	2004	In this study, DAS was selected for testing the inhibition of arylamine N-acetyltransferase (NAT) activity (N-acetylation of 2-aminofluorene) and gene expression (mRNA NAT) in human colon cancer cell lines (colo 205, colo 320 DM and colo 320 HSR).	2-aminofluorene	125-140	bromodomain containing 2	Homo sapiens	93-96
14667466-3	2004	The NAT activity was examined by high performance liquid chromatography and indicated that a 24 h DAS treatment decreases N-acetylation of 2-aminofluorene in three colon (colo 205, 320 DM and colo 320 HSR) cancer cell lines.	2-aminofluorene	139-154	bromodomain containing 2	Homo sapiens	4-7
15015580-3	2004	The activity of NAT was determined by high performance liquid chromatography (HPLC) assay for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and nonacetylated AF and PABA.	2-aminofluorene	120-135	bromodomain containing 2	Homo sapiens	16-19
17564303-1	2004	Evidence has shown that N-acetyltransferase (NAT) acetylated 2-aminofluorene (AF) to form N-acetyl-2-aminofluorene (AAF).	2-aminofluorene	61-76	bromodomain containing 2	Homo sapiens	24-43
17564303-1	2004	Evidence has shown that N-acetyltransferase (NAT) acetylated 2-aminofluorene (AF) to form N-acetyl-2-aminofluorene (AAF).	2-aminofluorene	61-76	bromodomain containing 2	Homo sapiens	45-48
17564303-5	2004	The activity of NAT was determined by high performance liquid chromatography (HPLC) assaying for the amounts of acetylated AF (AAF) or p-aminobenzoic acid (N-Ac-PABA) and nonacetylated AF or PABA.	2-aminofluorene	123-125	bromodomain containing 2	Homo sapiens	16-19
12929581-0	2003	N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski).	2-aminofluorene	72-87	bromodomain containing 2	Homo sapiens	0-19
12929581-0	2003	N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski).	2-aminofluorene	72-87	SKI proto-oncogene	Homo sapiens	160-163
12929581-3	2003	The NAT activity was determined by high performance liquid chromatography, assaying for the amounts of acetylated 2-aminofluorene (AAF) and non-acetylated 2-aminofluorene (AF).	2-aminofluorene	114-129	bromodomain containing 2	Homo sapiens	4-7
12929581-3	2003	The NAT activity was determined by high performance liquid chromatography, assaying for the amounts of acetylated 2-aminofluorene (AAF) and non-acetylated 2-aminofluorene (AF).	2-aminofluorene	155-170	bromodomain containing 2	Homo sapiens	4-7
12618593-5	2003	A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl.	2-aminofluorene	174-189	N-acetyltransferase 2	Homo sapiens	22-26
12618593-5	2003	A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl.	2-aminofluorene	174-189	N-acetyltransferase 2	Homo sapiens	37-41
12618593-5	2003	A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl.	2-aminofluorene	174-189	N-acetyltransferase 2	Homo sapiens	37-41
12618593-7	2003	NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.	2-aminofluorene	129-144	N-acetyltransferase 1	Homo sapiens	0-4
12618593-7	2003	NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.	2-aminofluorene	129-144	N-acetyltransferase 2	Homo sapiens	9-13
12639503-1	2003	CYP4B1 isoforms from rodents and other common laboratory animals are involved in the bioactivation of a range of protoxins, including 2-aminofluorene, 4-ipomeanol, and valproic acid.	2-aminofluorene	134-149	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	0-6
12680237-0	2003	Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene accompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line.	2-aminofluorene	49-64	bromodomain containing 2	Homo sapiens	78-97
12487326-1	2002	Our earlier study has demonstrated that following the exposure of rat to the arylamine carcinogen 2-aminofluorene, DNA-2-aminofluorene adducts were found in the target tissues liver, bladder, colon, lung and also in circulating leukocytes (lymphocytes and monocytes).	2-aminofluorene	98-113	DNA replication helicase/nuclease 2	Rattus norvegicus	115-120
12351147-6	2002	In this work, we have re-examined the feasibility of three proposed p450 oxidation mechanisms by comparing the experimental oxidation yields and rates of 1-naphthylamine (1-NA), 2-naphthylamine (2-NA) and 2-aminofluorene (2-AF).	2-aminofluorene	205-220	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
12222688-7	2002	The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4.	2-aminofluorene	73-88	N-acetyltransferase 2	Homo sapiens	177-181
12222688-7	2002	The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4.	2-aminofluorene	73-88	N-acetyltransferase 2	Homo sapiens	207-211
11955676-2	2002	The activity of NAT was measured by HPLC assaying for the amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF).	2-aminofluorene	78-93	bromodomain containing 2	Homo sapiens	16-19
15840428-6	2005	In contrast, 2-aminofluorene underwent CYP-mediated metabolism to > or = 4 different hydroxylated metabolites.	2-aminofluorene	13-28	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-42
15796204-0	2005	N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells.	2-aminofluorene	70-85	bromodomain containing 2	Homo sapiens	0-19
15796204-0	2005	N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells.	2-aminofluorene	94-109	bromodomain containing 2	Homo sapiens	0-19
15340647-3	2004	NAT activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) as substrates were examined in the cytosol of K. pneumoniae.	2-aminofluorene	51-66	bromodomain containing 2	Homo sapiens	0-3
15274316-0	2004	N-acetyltransferase activity is involved in paclitaxel-induced N-acetylation of 2-aminofluorene in human bladder cancer cells (T24).	2-aminofluorene	80-95	bromodomain containing 2	Homo sapiens	0-19
15274316-1	2004	Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens.	2-aminofluorene	81-96	bromodomain containing 2	Homo sapiens	10-29
15274316-1	2004	Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens.	2-aminofluorene	81-96	bromodomain containing 2	Homo sapiens	31-34
12929584-3	2003	The NAT activity was determined by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene (AAF) and p-aminobenzoic acid (N-Ac-PABA) and nonacetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	113-128	bromodomain containing 2	Homo sapiens	4-7
12929584-3	2003	The NAT activity was determined by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene (AAF) and p-aminobenzoic acid (N-Ac-PABA) and nonacetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	189-204	bromodomain containing 2	Homo sapiens	4-7
12396098-4	2002	The activity of NAT (N-acetylation of substrate) was measured and determined by high-performance liquid chromatography (HPLC) assaying for the amounts of acetylated 2-aminofluorene (AF) and nonacetylated AF.	2-aminofluorene	165-180	bromodomain containing 2	Homo sapiens	16-19
12396098-4	2002	The activity of NAT (N-acetylation of substrate) was measured and determined by high-performance liquid chromatography (HPLC) assaying for the amounts of acetylated 2-aminofluorene (AF) and nonacetylated AF.	2-aminofluorene	165-180	bromodomain containing 2	Homo sapiens	21-47
12230020-2	2002	The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF).	2-aminofluorene	160-164	bromodomain containing 2	Homo sapiens	4-7
11807928-2	2002	The activity of NAT was measured by high-performance liquid chromatography, assaying for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid and remaining 2-aminofluorene and p-aminobenzoic acid.	2-aminofluorene	113-128	bromodomain containing 2	Homo sapiens	16-19
15618652-10	2002	Genotoxic activation of 2-aminofluorene (a marker for Cyp4b1) by male and female mouse kidney microsomes were not affected by the SCD phenotype.	2-aminofluorene	24-39	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	54-60
11682644-8	2001	When tested in the Ames test, Aroclor S9 and PB/NF S9 were the most effective in the activation of benzo[a]pyrene and 3-methylcholanthrene which are metabolized mainly by CYP1A1; additionally, the highest mutagenic potency of 2-aminofluorene and N-nitrosodipropylamine, which are activated by CYP1A2 and CYP2B, respectively, were obtained with PB/NF S9.	2-aminofluorene	226-241	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	171-177
11828994-3	2001	The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF).	2-aminofluorene	35-50	bromodomain containing 2	Homo sapiens	4-7
11828994-3	2001	The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF).	2-aminofluorene	145-160	bromodomain containing 2	Homo sapiens	4-7
11828994-3	2001	The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF).	2-aminofluorene	145-160	bromodomain containing 2	Homo sapiens	4-7
11808848-4	2001	Using 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA) as substrates, NAT activity of all samples was determined by high pressure liquid chromatography.	2-aminofluorene	6-21	bromodomain containing 2	Homo sapiens	75-78
11700952-4	2001	The activity of NAT was measured by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene and p-aminobenzoic acid and nonacetylated 2-aminofluorene and p-amonibenzoic acid.	2-aminofluorene	114-129	N-acetyltransferase 1	Rattus norvegicus	16-19
11700952-4	2001	The activity of NAT was measured by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene and p-aminobenzoic acid and nonacetylated 2-aminofluorene and p-amonibenzoic acid.	2-aminofluorene	172-187	N-acetyltransferase 1	Rattus norvegicus	16-19
11337936-5	2001	Reductions in catalytic activity for the N-acetylation of a sulfonamide drug (sulfamethazine) and an aromatic amine carcinogen (2-aminofluorene) were observed for NAT2 variants possessing G191A (R64Q), T341C (I114T), A434C (E145P), G590A (R197Q), A845C (K282T) or G857A (G286T).	2-aminofluorene	128-143	N-acetyltransferase 2	Homo sapiens	163-167
11764764-1	2001	N-acetyltransferase (NAT) activity was determined in 40 human benign prostatic hyperplasia tissues using 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) as substrates.	2-aminofluorene	105-120	bromodomain containing 2	Homo sapiens	0-19
11764764-1	2001	N-acetyltransferase (NAT) activity was determined in 40 human benign prostatic hyperplasia tissues using 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) as substrates.	2-aminofluorene	105-120	bromodomain containing 2	Homo sapiens	21-24
11396967-2	2001	Hepatic microsomes of transgenic mice catalyzed omega-hydroxylation of lauric acid and also activated 2-aminofluorene (2-AF), which is a typical substrate for CYP4B1, to mutagenic compounds detected by an umu gene expression assay.	2-aminofluorene	102-117	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	159-165
10944003-2	2000	The NAT activity was measured by high preformance liquid chromatography (HPLC) assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	116-131	N-acetyltransferase 1	Rattus norvegicus	4-7
11321474-2	2001	By using high performance liquid chromatography, NAT activity on acetylation of 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) were examined.	2-aminofluorene	80-95	bromodomain containing 2	Homo sapiens	49-52
11527074-2	2001	By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined.	2-aminofluorene	81-96	bromodomain containing 2	Homo sapiens	49-52
12889515-6	2001	But the results also showed that NAT activity and 2-Aminofluorene-DNA adduct formation in HL-60 cells were inhibited and decreased by tamoxifen in a dose-dependent manner when the doses of tamoxifen up to 100 micro M. We also examined the standard steady-state kinetic analysis, and the data showed that tamoxifen may be an uncompetitive inhibitor to NAT activity in cytosols based on the decrease apparent values of Km and Vmax.	2-aminofluorene	50-65	bromodomain containing 2	Homo sapiens	351-354
11011961-3	2000	The activity of NAT was measured using high-performance liquid chromatography (HPLC), by assaying for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and the remaining amounts of AF and PABA.	2-aminofluorene	128-143	bromodomain containing 2	Homo sapiens	16-19
11396144-2	2001	BHA or BHT were added to the cytosols or to the medium of human colon tumor cells: The NAT activity was measured by high performance liquid chromatography, assaying the amounts of acetylated 2-aminoflluorene (AAF), p aminobenzoic acid (N-Ac-PABA), nonacetylated 2 aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	262-277	bromodomain containing 2	Homo sapiens	87-90
11062028-3	2000	In the present study, human bladder microsomes activated 2-aminofluorene which is a typical substrate for CYP4B1 and is a bladder carcinogen.	2-aminofluorene	57-72	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	106-112
11038234-4	2000	The NAT activity in cytosol and intact PC-3 cells were measured by HPLC assaying exhibited for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid, 2-aminofluorene and p-aminobenzoic acid.	2-aminofluorene	119-134	bromodomain containing 2	Homo sapiens	4-7
10944003-2	2000	The NAT activity was measured by high preformance liquid chromatography (HPLC) assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	134-136	N-acetyltransferase 1	Rattus norvegicus	4-7
10727902-7	2000	No clear involvement of cytochrome P450 could be demonstrated for activation of 2-nitrofluorene to a mutagenic metabolite, whereas a role for CYP1A2 in the bioactivation of 2-aminofluorene is suggested.	2-aminofluorene	173-188	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
10920545-3	2000	NAT activity in rat glial tumor cells was measured by high performance liquid chromatography (HPLC) using 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA) as substrares.	2-aminofluorene	106-121	N-acetyltransferase 1	Rattus norvegicus	0-3
10920545-5	2000	The activities (Mean +/- SD) of NAT in rat glial cells was 1.08 +/- 0.18 nmol/min/mg protein for the acetylation of 2-aminofluorene (n = 12), and 0.96 +/- 0.16 nmol/min/mg protein for the acetylation of p-aminobenzoic acid (n = 12).	2-aminofluorene	116-131	N-acetyltransferase 1	Rattus norvegicus	32-35
10418949-2	1999	The NAT activity was measured by HPLC assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	75-90	bromodomain containing 2	Homo sapiens	4-7
10890504-6	2000	In contrast, 2-aminofluorene NAT activity in C57B1/6 hepatic cytosol was twice that of the A/J strain and activities in both strains of mice were greater than in rat.	2-aminofluorene	13-28	solute carrier family 38, member 3	Mus musculus	29-32
10547619-2	1999	The activity of NAT was measured by high-performance liquid chromatography, assaying for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid and remaining 2-aminofluorene and p-aminobenzoic acid.	2-aminofluorene	113-128	bromodomain containing 2	Homo sapiens	16-19
10782490-2	2000	Using high-performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene and remaining unacetylated 2-aminofluorene were examined.	2-aminofluorene	78-93	N-acetyltransferase 1	Rattus norvegicus	46-49
10885506-2	2000	Using high performance liquid chromatography, the NAT activity for acetylation of arylamine substrates (2-aminofluorene and p-aminobenzoic acid) was determined.	2-aminofluorene	104-119	bromodomain containing 2	Homo sapiens	50-53
10885506-3	2000	The cytosolic NAT activity in human liver tumour cells was 2.74+/-0.26 and 1.68+/-0.20 nmol/min/mg of protein for 2-aminofluorene and p-aminobenzoic acid, respectively.	2-aminofluorene	114-129	bromodomain containing 2	Homo sapiens	14-17
10543022-4	1999	Following exposure of rats to the 2-aminofluorene, with or without pretreatment with butylated hydroxyanisole and butylated hydroxytoluene, DNA-2-aminofluorene adducts were observed in the target tissues of liver and bladder, and also in circulating leukocytes.	2-aminofluorene	34-49	DNA replication helicase/nuclease 2	Rattus norvegicus	140-145
10234471-2	1999	The NAT activity was measured by high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (2-AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	109-124	bromodomain containing 2	Homo sapiens	4-7
10418950-1	1999	Paeonol was used to determine any effects on the N-acetyltransferase (NAT) activity in human colon tumour cells as measured by HPLC exhibited for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA).	2-aminofluorene	170-185	bromodomain containing 2	Homo sapiens	70-73
10226534-2	1999	The bacterial NAT activities were determined by HPLC measuring the acetylation of 2-aminofluorene (2-AF).	2-aminofluorene	82-97	bromodomain containing 2	Homo sapiens	14-17
9571233-6	1998	Under the conditions used, mouse Nat2 had 20-, 2.4-, and 5.4-fold higher catalytic activity for p-aminobenzoic acid, 5-aminosalicylic acid, and 2-aminofluorene, respectively, than Nat1.	2-aminofluorene	144-159	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	33-37
9608747-2	1998	Using high performance liquid chromatography (HPLC) to analyze NAT activity in bacteria, the authors found that Pseudomonas aeruginosa exhibited high NAT activity with 2-aminofluorene (2-AF) as substrate.	2-aminofluorene	168-183	bromodomain containing 2	Homo sapiens	63-66
9608747-2	1998	Using high performance liquid chromatography (HPLC) to analyze NAT activity in bacteria, the authors found that Pseudomonas aeruginosa exhibited high NAT activity with 2-aminofluorene (2-AF) as substrate.	2-aminofluorene	168-183	bromodomain containing 2	Homo sapiens	150-153
9858928-2	1998	Using high performance liquid chromatography, NAT activity on the acetylation of 2-aminofluorene and p-aminobenzoic acid was examined.	2-aminofluorene	81-96	bromodomain containing 2	Homo sapiens	46-49
9571233-6	1998	Under the conditions used, mouse Nat2 had 20-, 2.4-, and 5.4-fold higher catalytic activity for p-aminobenzoic acid, 5-aminosalicylic acid, and 2-aminofluorene, respectively, than Nat1.	2-aminofluorene	144-159	N-acetyl transferase 1	Mus musculus	180-184
10592822-1	1997	N-Acetyltransferase (NAT) activities were determined by incubation of Staphylococcus aureus cytosols with p-aminobenzoic acid (PABA) or 2-aminofluorene (2-AF) followed by high pressure liquid chromatography assays.	2-aminofluorene	136-151	AT695_RS04655	Staphylococcus aureus	0-19
9449220-1	1997	This study was designed to assess the effect of vitamin C on arylamine N-acetyltransferase (NAT) activity in Klebsiella pneumoniae by using HPLC to measure the acetylation of 2-aminofluorene (2-AF) with and without vitamin C.	2-aminofluorene	175-190	bromodomain containing 2	Homo sapiens	92-95
9459121-4	1998	Forty-eight hours after irradiation of UVB (200 J/m2), the activity was not increased (114 +/- 8.3%, n = 3), while increase in N-acetylating capacity for 2-aminofluorene (substrate for NAT1 and NAT2) amounted to 201 +/- 16% (n = 3).	2-aminofluorene	154-169	N-acetyltransferase 1	Homo sapiens	185-189
9459121-4	1998	Forty-eight hours after irradiation of UVB (200 J/m2), the activity was not increased (114 +/- 8.3%, n = 3), while increase in N-acetylating capacity for 2-aminofluorene (substrate for NAT1 and NAT2) amounted to 201 +/- 16% (n = 3).	2-aminofluorene	154-169	N-acetyltransferase 2	Homo sapiens	194-198
10592822-1	1997	N-Acetyltransferase (NAT) activities were determined by incubation of Staphylococcus aureus cytosols with p-aminobenzoic acid (PABA) or 2-aminofluorene (2-AF) followed by high pressure liquid chromatography assays.	2-aminofluorene	136-151	AT695_RS04655	Staphylococcus aureus	21-24
10592822-1	1997	N-Acetyltransferase (NAT) activities were determined by incubation of Staphylococcus aureus cytosols with p-aminobenzoic acid (PABA) or 2-aminofluorene (2-AF) followed by high pressure liquid chromatography assays.	2-aminofluorene	153-157	AT695_RS04655	Staphylococcus aureus	0-19
10592822-1	1997	N-Acetyltransferase (NAT) activities were determined by incubation of Staphylococcus aureus cytosols with p-aminobenzoic acid (PABA) or 2-aminofluorene (2-AF) followed by high pressure liquid chromatography assays.	2-aminofluorene	153-157	AT695_RS04655	Staphylococcus aureus	21-24
8182542-4	1994	Arylamine N-acetyltransferase (NAT) catalyzes the acetyl CoA-dependent N-acetylation of primary arylamine and hydrazine substrates such as sulfamethazine, isoniazid, p-aminobenzoic acid as well as arylamine carcinogens such as 2-aminofluorene and benzidine.	2-aminofluorene	227-242	bromodomain containing 2	Homo sapiens	31-34
9163691-10	1997	Other compounds that induced p53 in the rat liver were 2-aminofluorene (administered by drinking water for two weeks) and tris-(2,3-dibromopropyl)phosphate.	2-aminofluorene	55-70	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	29-32
8845861-14	1996	Intrinsic clearance (Vmax/Km) calculations suggest that N-acetylation of p-aminobenzoic acid and 2-aminofluorene in Syrian hamsters is catalysed primarily by NAT2 (NAT2 15) in rapid acetylators but by NAT1 (NAT1 9) in slow acetylators.	2-aminofluorene	97-112	arylamine N-acetyltransferase 2	Mesocricetus auratus	158-162
8845861-14	1996	Intrinsic clearance (Vmax/Km) calculations suggest that N-acetylation of p-aminobenzoic acid and 2-aminofluorene in Syrian hamsters is catalysed primarily by NAT2 (NAT2 15) in rapid acetylators but by NAT1 (NAT1 9) in slow acetylators.	2-aminofluorene	97-112	arylamine N-acetyltransferase 2	Mesocricetus auratus	164-171
8845861-14	1996	Intrinsic clearance (Vmax/Km) calculations suggest that N-acetylation of p-aminobenzoic acid and 2-aminofluorene in Syrian hamsters is catalysed primarily by NAT2 (NAT2 15) in rapid acetylators but by NAT1 (NAT1 9) in slow acetylators.	2-aminofluorene	97-112	arylamine N-acetyltransferase 1	Mesocricetus auratus	201-205
8845861-14	1996	Intrinsic clearance (Vmax/Km) calculations suggest that N-acetylation of p-aminobenzoic acid and 2-aminofluorene in Syrian hamsters is catalysed primarily by NAT2 (NAT2 15) in rapid acetylators but by NAT1 (NAT1 9) in slow acetylators.	2-aminofluorene	97-112	arylamine N-acetyltransferase 1	Mesocricetus auratus	207-213
7669073-5	1995	The apparent Km values (at 100 microM acetyl CoA as co-substrate) of the different NAT2 variants for sulphamethazine, dapsone, p-anisidine, 2-aminofluorene, procainamide and isoniazid were determined.	2-aminofluorene	140-155	N-acetyltransferase 2	Homo sapiens	83-87
7527492-3	1994	Sister chromatid exchanges, however, were induced by 2-aminoanthracene, 2-aminofluorene and 2-acetylaminofluorene in the CYP1A2-proficient cells, but not in the CYP1A2-deficient cells.	2-aminofluorene	72-87	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	121-127
8035095-6	1994	In the current study we characterized the activity of human placental NAT and deacetylase toward the carcinogenic arylamine, 2-aminofluorene (AF) and its acetylated metabolite, 2-acetylaminofluorene (AAF).	2-aminofluorene	125-140	bromodomain containing 2	Homo sapiens	70-73
7503773-4	1995	When yeast expressing rat CYP1A1 was exposed to 2-aminofluorene, a concentration-dependent induction of RNR3 was observed.	2-aminofluorene	48-63	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	26-32
7503773-4	1995	When yeast expressing rat CYP1A1 was exposed to 2-aminofluorene, a concentration-dependent induction of RNR3 was observed.	2-aminofluorene	48-63	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	104-108
7894498-10	1994	All rabbit gastrointestinal tissues other than stomach possess a high capacity for the activation of 2-aminofluorene compatible with CYP4B1 expression.	2-aminofluorene	101-116	cytochrome P450 4B1	Oryctolagus cuniculus	133-139
8291051-0	1994	Acetylator genotype-dependent formation of 2-aminofluorene-hemoglobin adducts in rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.	2-aminofluorene	43-58	arylamine N-acetyltransferase 2	Mesocricetus auratus	139-143
8291057-11	1994	The NAT2-dependent expression of N-acetyltransferase activity was evident toward p-aminobenzoic acid, 4-aminophenol, 2-aminofluorene, 4-aminobiphenyl, beta-naphthylamine, and 3,2"-dimethyl-4-amino-biphenyl in liver, kidney, colon, lung, and urinary bladder cytosols.	2-aminofluorene	117-132	arylamine N-acetyltransferase 2	Mesocricetus auratus	4-8
1761209-1	1991	It has been shown that the rad1-5 mutation which alters excision repair in Saccharomyces cerevisiae yeast increased reversion frequency of the ochre mutation his7-1 and the frequency of intragenic mitotic recombination in the LYS2 gene induced by 2-aminofluorene and 2-acetylaminofluorene, as compared with the wild type strains activated in vitro by 39 mix from chicken liver.	2-aminofluorene	247-262	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	27-31
8248926-7	1993	The CYP4B1 substrate 2-aminofluorene, when dosed to rats, caused a sixfold decrease in ipomeanol toxicity.	2-aminofluorene	21-36	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	4-10
7905384-1	1993	The distribution of N-acetyltransferase (NAT) activity in 35 tissues of inbred rapid acetylator C57BL/6J and slow acetylator congenic B6.A-NatS mice was determined by incubation of tissue cytosols with 2-aminofluorene or p-aminobenzoic acid followed by HPLC assay.	2-aminofluorene	202-217	solute carrier family 38, member 3	Mus musculus	20-39
7905384-1	1993	The distribution of N-acetyltransferase (NAT) activity in 35 tissues of inbred rapid acetylator C57BL/6J and slow acetylator congenic B6.A-NatS mice was determined by incubation of tissue cytosols with 2-aminofluorene or p-aminobenzoic acid followed by HPLC assay.	2-aminofluorene	202-217	solute carrier family 38, member 3	Mus musculus	41-44
8425184-16	1993	In rapid acetylator hamster colon, NAT2/NAT1 activity ratios were 18 and 13 for the N-acetylation of 2-aminofluorene and 4-aminobiphenyl and 28 for the O-acetylation of N-hydroxy-2-aminofluorene.	2-aminofluorene	101-116	N-acetyltransferase 2	Homo sapiens	35-39
8425184-16	1993	In rapid acetylator hamster colon, NAT2/NAT1 activity ratios were 18 and 13 for the N-acetylation of 2-aminofluorene and 4-aminobiphenyl and 28 for the O-acetylation of N-hydroxy-2-aminofluorene.	2-aminofluorene	101-116	arylamine N-acetyltransferase 1	Mesocricetus auratus	40-44
1761209-1	1991	It has been shown that the rad1-5 mutation which alters excision repair in Saccharomyces cerevisiae yeast increased reversion frequency of the ochre mutation his7-1 and the frequency of intragenic mitotic recombination in the LYS2 gene induced by 2-aminofluorene and 2-acetylaminofluorene, as compared with the wild type strains activated in vitro by 39 mix from chicken liver.	2-aminofluorene	247-262	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	226-230
2009137-8	1991	In agreement with the results of purified AT-1, the cDNA-expressed protein exhibited a high capacity for N-acetylation of 4-aminoazobenzene and 2-aminofluorene, and O-acetylation of 2-hydroxyamino-6-methyldipyrido [1,2-a:3",2"-d] imidazole, whereas no activity was found for the N-acetylation of p-aminobenzoic acid.	2-aminofluorene	144-159	angiotensin II receptor type 1	Homo sapiens	42-46
1996083-10	1991	Interestingly, the carcinogen 2-aminofluorene was very efficiently metabolized by both NAT1 and NAT2.	2-aminofluorene	30-45	N-acetyltransferase 1	Homo sapiens	87-91
1996083-10	1991	Interestingly, the carcinogen 2-aminofluorene was very efficiently metabolized by both NAT1 and NAT2.	2-aminofluorene	30-45	N-acetyltransferase 2	Homo sapiens	96-100
1781947-0	1991	A circular dichroism study on the conformation of d(CGT) modified with N-acetyl-2-aminofluorene or 2-aminofluorene.	2-aminofluorene	80-95	UDP glycosyltransferase 8	Homo sapiens	52-55
1781947-1	1991	The trinucleotide d(CGT) was modified by covalent binding of the carcinogen N-acetyl-2-aminofluorene (AAF) or 2-aminofluorene (AF) at the C8 position of the guanine base.	2-aminofluorene	85-100	UDP glycosyltransferase 8	Homo sapiens	20-23
4053055-0	1985	The cytochrome P-450 monooxygenase system of rabbit bladder mucosa: enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene.	2-aminofluorene	124-139	cytochrome P-450	Oryctolagus cuniculus	4-20
3123085-0	1988	Inhibition of 2-aminofluorene mutagenesis in bacteria by inducers of cytochrome P-450d.	2-aminofluorene	14-29	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	69-86
3123085-2	1988	We investigated the ability of two inducers of cytochrome P-450d, Aroclor 1254 and isosafrole, to inhibit the microsomal activation of 2-aminofluorene to a mutagen as measured in Salmonella typhimurium.	2-aminofluorene	135-150	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	47-64
3574284-1	1987	The presence of homologues of rabbit cytochrome P-450 isozyme 5 in pulmonary and hepatic microsomal preparations from guinea pig, mouse, monkey, hamster, and rat was examined by immunoblotting and inhibition of metabolism of 2-aminofluorene with antibodies to isozyme 5.	2-aminofluorene	225-240	cytochrome P450 4B1	Oryctolagus cuniculus	37-63
2134671-9	1990	Biochemical studies of liver NAT and O-acetyltransferase (OAT) activities showed a direct correlation between the levels of liver 2-aminofluorene (AF) NAT activity and levels of liver DNA-adduct formation, but the role of OAT activity in adduct formation in the mouse remains unclear.	2-aminofluorene	130-145	CAS1 domain containing 1	Mus musculus	37-56
2134671-9	1990	Biochemical studies of liver NAT and O-acetyltransferase (OAT) activities showed a direct correlation between the levels of liver 2-aminofluorene (AF) NAT activity and levels of liver DNA-adduct formation, but the role of OAT activity in adduct formation in the mouse remains unclear.	2-aminofluorene	130-145	solute carrier family 38, member 3	Mus musculus	29-32
2568902-8	1989	Comparison of homozygous rapid and slow acetylator bladder cytosol showed that the apparent Vmax for 2-aminofluorene NAT activity was significantly higher in rapid than slow acetylators (6-fold in cytosol, 50-fold in the polymorphic NAT isozyme).	2-aminofluorene	101-116	bromodomain containing 2	Homo sapiens	117-120
2568902-8	1989	Comparison of homozygous rapid and slow acetylator bladder cytosol showed that the apparent Vmax for 2-aminofluorene NAT activity was significantly higher in rapid than slow acetylators (6-fold in cytosol, 50-fold in the polymorphic NAT isozyme).	2-aminofluorene	101-116	bromodomain containing 2	Homo sapiens	233-236
3390817-2	1988	The N-hydroxy, N-hydroxy-N-acetyl, N-hydroxy-N-glucuronosyl derivatives of 2-aminofluorene (2-AF) and 4-aminobiphenyl (4-ABP) induced UDS in primary cultures of rat mammary epithelial cells, but 2-AF, the O-glucuronide of N-hydroxy-N-acetyl-2-AF (N-OH-AAF) and 4-ABP did not.	2-aminofluorene	75-90	amine oxidase, copper containing 1	Rattus norvegicus	263-266
3390817-2	1988	The N-hydroxy, N-hydroxy-N-acetyl, N-hydroxy-N-glucuronosyl derivatives of 2-aminofluorene (2-AF) and 4-aminobiphenyl (4-ABP) induced UDS in primary cultures of rat mammary epithelial cells, but 2-AF, the O-glucuronide of N-hydroxy-N-acetyl-2-AF (N-OH-AAF) and 4-ABP did not.	2-aminofluorene	92-96	amine oxidase, copper containing 1	Rattus norvegicus	121-124
3390817-2	1988	The N-hydroxy, N-hydroxy-N-acetyl, N-hydroxy-N-glucuronosyl derivatives of 2-aminofluorene (2-AF) and 4-aminobiphenyl (4-ABP) induced UDS in primary cultures of rat mammary epithelial cells, but 2-AF, the O-glucuronide of N-hydroxy-N-acetyl-2-AF (N-OH-AAF) and 4-ABP did not.	2-aminofluorene	92-96	amine oxidase, copper containing 1	Rattus norvegicus	263-266
3943517-2	1986	The amount of cytochrome P-450c was found to be increased about 60-fold after treatment with 2-aminofluorene and 3-aminofluorene.	2-aminofluorene	93-108	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	14-31
4053055-8	1985	The metabolism of 2-aminofluorene was inhibited by antibodies to cytochrome P-450 form 5 or to reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase and by carbon monoxide (CO:O2, 4:1), but not by antibodies to cytochrome P-450 form 2.	2-aminofluorene	18-33	cytochrome P-450	Oryctolagus cuniculus	65-81
4053055-8	1985	The metabolism of 2-aminofluorene was inhibited by antibodies to cytochrome P-450 form 5 or to reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase and by carbon monoxide (CO:O2, 4:1), but not by antibodies to cytochrome P-450 form 2.	2-aminofluorene	18-33	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	147-173
4053055-8	1985	The metabolism of 2-aminofluorene was inhibited by antibodies to cytochrome P-450 form 5 or to reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase and by carbon monoxide (CO:O2, 4:1), but not by antibodies to cytochrome P-450 form 2.	2-aminofluorene	18-33	cytochrome P-450	Oryctolagus cuniculus	147-163
11219850-0	1980	Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.	2-aminofluorene	114-129	homeobox C8	Homo sapiens	68-71
6343182-6	1983	2-aminofluorene was a potent recombinogen after metabolic activation, but proved a poor inducer of reversions of the ochre mutation.	2-aminofluorene	0-15	ochre	Mus musculus	117-122
30358977-9	2018	Metabolic assays using recombinant proteins showed that cynomolgus NAT1 and NAT2 metabolized human NAT substrates, including p-aminobenzoic acid, sulfamethazine, isoniazid, and 2-aminofluorene.	2-aminofluorene	177-192	arylamine N-acetyltransferase 1	Macaca fascicularis	67-71
13359446-0	1956	Hydrolysis of amino acid amide derivatives of 2-aminofluorene, 4-aminobiphenyl and 4, 4-diaminobiphenyl by leucine aminopeptidase.	2-aminofluorene	46-61	carboxypeptidase Q	Homo sapiens	115-129
33136180-6	2021	Benzidine, 3,4-DMA, and 2-AF were preferential human NAT1 substrates, while 3,5-DMA, 2,5-DMA, 3-EA, and ABP were preferential human NAT2 substrates.	2-aminofluorene	24-28	N-acetyltransferase 1	Homo sapiens	53-57
30358977-9	2018	Metabolic assays using recombinant proteins showed that cynomolgus NAT1 and NAT2 metabolized human NAT substrates, including p-aminobenzoic acid, sulfamethazine, isoniazid, and 2-aminofluorene.	2-aminofluorene	177-192	arylamine N-acetyltransferase 2	Macaca fascicularis	76-80