PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2597157-3	1989	The binding of CRF-BP to CRF decreased after treatment with endoglycosidase H. These results indicate that the CRF-BP is a glycoprotein that contains asparagine N-linked-type oligosaccharides, and such oligosaccharide chains are important for CRF-BP binding.	Asparagine	150-160	corticotropin releasing hormone binding protein	Homo sapiens	15-21
2597157-3	1989	The binding of CRF-BP to CRF decreased after treatment with endoglycosidase H. These results indicate that the CRF-BP is a glycoprotein that contains asparagine N-linked-type oligosaccharides, and such oligosaccharide chains are important for CRF-BP binding.	Asparagine	150-160	corticotropin releasing hormone binding protein	Homo sapiens	111-117
2597157-3	1989	The binding of CRF-BP to CRF decreased after treatment with endoglycosidase H. These results indicate that the CRF-BP is a glycoprotein that contains asparagine N-linked-type oligosaccharides, and such oligosaccharide chains are important for CRF-BP binding.	Asparagine	150-160	corticotropin releasing hormone binding protein	Homo sapiens	111-117
2480386-3	1989	DR3 and DRw52 differ uniquely from other other DR antigens at position 77 in the beta 1-domain of their beta-chains where there is asparagine instead of threonine.	Asparagine	131-141	TNF receptor superfamily member 25	Homo sapiens	0-3
2556477-0	1989	Asparagine-linked glycosylation of cytochrome b558 large subunit varies in different human phagocytic cells.	Asparagine	0-10	mitochondrially encoded cytochrome b	Homo sapiens	35-47
2592374-5	1989	Carbohydrate mapping by mass spectrometry was used to establish that both potential Asn-linked glycosylation sites in sCD4 (Asn271 and Asn300) have oligosaccharides attached.	Asparagine	84-87	stearoyl-coenzyme A desaturase 4	Mus musculus	118-122
2632077-4	1989	The dynamic range of the NH4+ ion sensor was 10(-7)--10(-3) M. Urea, adenosine, and asparagine sensors were prepared by coating the surface of the NH4+-ion sensor with urease, adenosine deaminase, and asparaginase membranes, respectively.	Asparagine	84-94	adenosine deaminase	Homo sapiens	176-195
2584723-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3.	Asparagine	89-99	lysophosphatidylcholine acyltransferase 3	Homo sapiens	29-32
2808357-3	1989	As in the case of CEA, only asparagine-linked sugar chains are included in NCA-2.	Asparagine	28-38	CEA cell adhesion molecule 3	Homo sapiens	18-21
2676155-7	1989	P2B/LAMP-1 possesses 20 asparagine-linked glycosylation sites separated into equal halves by a central, putative hinge region and is anchored by a carboxy, membrane-spanning, domain.	Asparagine	24-34	lysosomal-associated membrane protein 1	Mus musculus	0-3
2676155-7	1989	P2B/LAMP-1 possesses 20 asparagine-linked glycosylation sites separated into equal halves by a central, putative hinge region and is anchored by a carboxy, membrane-spanning, domain.	Asparagine	24-34	lysosomal-associated membrane protein 1	Mus musculus	4-10
2520774-4	1989	Double couplings with an O-unprotected saccharide, as in Fmoc-Asn(GlcNAc)-OH resulted in acceptable coupling rates even with a synthetically difficult sequence corresponding to the T-cell epitopic peptide from the C-terminus of pigeon cytochrome c.	Asparagine	62-65	cytochrome c, somatic	Homo sapiens	235-247
2583526-9	1989	The change of Thr-412----Ile in the E2 protein results in the loss of a putative glycosylation site at Asn-410, which offers a plausible explanation for decreased glycosylation of the E2 protein from the vaccine strain of rubella virus.	Asparagine	103-106	ubiquitin conjugating enzyme E2 B	Homo sapiens	36-46
2583526-9	1989	The change of Thr-412----Ile in the E2 protein results in the loss of a putative glycosylation site at Asn-410, which offers a plausible explanation for decreased glycosylation of the E2 protein from the vaccine strain of rubella virus.	Asparagine	103-106	ubiquitin conjugating enzyme E2 B	Homo sapiens	184-194
2484021-8	1989	This result suggests that alpha 2u-globulin, sequestered into the kidney lysosomes, is cleaved intralysosomally between the 9th asparagine and the 10th leucine, and the degradative intermediate, thus produced, is accumulated in the lysosomes.	Asparagine	128-138	alpha2u globulin	Rattus norvegicus	26-43
2683070-1	1989	The prohormone-processing endoprotease (KEX2 gene product) of the yeast Saccharomyces cerevisiae is a membrane-bound, 135,000-dalton glycoprotein, which contains both asparagine-linked and serine- and threonine-linked oligosaccharide and resides in a secretory compartment.	Asparagine	167-177	kexin KEX2	Saccharomyces cerevisiae S288C	40-44
2669516-3	1989	The amino acid sequence of this peptide is H-Gly-Asn-Trp-Ala-Ala-Gly-His-Leu-Met-NH2 ([Ala6]GRP-10).	Asparagine	49-52	gastrin releasing peptide	Homo sapiens	92-98
2477364-4	1989	Previous studies demonstrated different roles of each of the two alpha N-linked glycosylation sites (Asn-52 and Asn-78) in secretion of the uncombined subunit and the biologic activity of hCG dimer.	Asparagine	101-104	chorionic gonadotropin subunit beta 5	Homo sapiens	188-191
2477364-4	1989	Previous studies demonstrated different roles of each of the two alpha N-linked glycosylation sites (Asn-52 and Asn-78) in secretion of the uncombined subunit and the biologic activity of hCG dimer.	Asparagine	112-115	chorionic gonadotropin subunit beta 5	Homo sapiens	188-191
2514791-2	1989	The t-PA polypeptide has four potential N-glycosylation sites of which three are occupied in type I (Asn-117, -184, and -448) and two in type II (Asn-117 and -448).	Asparagine	101-104	plasminogen activator, tissue type	Homo sapiens	4-8
2514791-2	1989	The t-PA polypeptide has four potential N-glycosylation sites of which three are occupied in type I (Asn-117, -184, and -448) and two in type II (Asn-117 and -448).	Asparagine	146-149	plasminogen activator, tissue type	Homo sapiens	4-8
2571506-5	1989	The VH441 gene segment and all seven mAb contain a potential glycosylation site at Asn 58 in complementarity-determining region (CDR)2.	Asparagine	83-86	cerebellar degeneration related protein 2	Homo sapiens	129-134
2757392-0	1989	The structures of the asparagine-linked sugar chains of human apolipoprotein B-100.	Asparagine	22-32	apolipoprotein B	Homo sapiens	62-82
2757392-1	1989	The asparagine-linked sugar chains of human apolipoprotein B-100 were liberated from the polypeptide portion by hydrazinolysis followed by N-acetylation and NaB3H4 reduction.	Asparagine	4-14	apolipoprotein B	Homo sapiens	44-64
2753907-9	1989	The carboxypeptidase M sequence contains six potential Asn-linked glycosylation sites, consistent with its glycoprotein nature.	Asparagine	55-58	carboxypeptidase M	Homo sapiens	4-22
2818682-2	1989	Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at the critical positions 5 and 8, while the hydroxyl group of N-terminal Thr and its free amino function are not essential requirements for CD4 receptor interactions.	Asparagine	85-88	CD4 molecule	Homo sapiens	335-347
2507634-3	1989	To remove this N-linked carbohydrate, Asn-297, the oligosaccharide attachment residue, was changed to either Gln (a conservative replacement) or His for IgG1 or Lys for IgG3 (nonconservative replacements) by site-directed mutagenesis.	Asparagine	38-41	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	169-173
2599767-2	1989	Asparagine was activated by DCC/HOBt, BOP (Castro"s reagent) or introduced as the pentafluorophenyl ester.	Asparagine	0-10	DCC netrin 1 receptor	Homo sapiens	28-31
24201516-3	1989	Patatin isolated from the leaves of transgenic tobacco plants is glycosylated at asparagine (Asn)(60), and Asn(90), but the third glycosylation site (Asn(202)) has no glycan.	Asparagine	81-91	Patatin class I	Solanum tuberosum	0-7
24201516-3	1989	Patatin isolated from the leaves of transgenic tobacco plants is glycosylated at asparagine (Asn)(60), and Asn(90), but the third glycosylation site (Asn(202)) has no glycan.	Asparagine	93-96	Patatin class I	Solanum tuberosum	0-7
24201516-3	1989	Patatin isolated from the leaves of transgenic tobacco plants is glycosylated at asparagine (Asn)(60), and Asn(90), but the third glycosylation site (Asn(202)) has no glycan.	Asparagine	107-110	Patatin class I	Solanum tuberosum	0-7
24201516-3	1989	Patatin isolated from the leaves of transgenic tobacco plants is glycosylated at asparagine (Asn)(60), and Asn(90), but the third glycosylation site (Asn(202)) has no glycan.	Asparagine	107-110	Patatin class I	Solanum tuberosum	0-7
2473125-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.	Asparagine	89-99	lysophosphatidylcholine acyltransferase 3	Homo sapiens	29-32
2473125-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.	Asparagine	89-99	Fc gamma receptor and transporter	Homo sapiens	148-159
2473125-8	1989	The result of this point mutation at the translational level is the substitution of an asparagine residue in C3S for an aspartic acid residue in C3F.	Asparagine	87-97	lysophosphatidylcholine acyltransferase 3	Homo sapiens	145-148
2808319-1	1989	Fibronectin purified from human term amniotic fluid contains 10 asparagine-linked sugar chains in one molecule.	Asparagine	64-74	fibronectin 1	Homo sapiens	0-11
2804442-4	1989	The molecular weight, 2857.4 and 2858.4, indicated the amino acid substitutions of asparagine and aspartic acid, respectively, for lysine at position 82 of beta globin chain.	Asparagine	83-93	hemoglobin subunit beta	Homo sapiens	156-173
2489081-4	1989	The residues Arg 151 and Asn 232 of ABP from bidentate hydrogen bonds with both L-arabinose and D-galactose, but not with D-fucose or D-glucose.	Asparagine	25-28	sex hormone binding globulin	Homo sapiens	36-39
2796989-7	1989	Changing an Asn residue to a Lys at the hypothetical cleavage site resulted in a PI-G-linked protein having a detectable alteration in electrophoretic mobility.	Asparagine	12-15	stathmin 1	Mus musculus	81-85
2568118-11	1989	Six posttranslational modifications of both PrP isoforms have been identified: (1) cleavage of an N-terminal signal peptide, (2) an intramolecular disulfide bond, (3) an N-linked oligosaccharide attached to Asn 181, (4) a second oligosaccharide attached to Asn 197, (5) cleavage of a C-terminal hydrophobic peptide, and (6) a phosphatidylinositol glycolipid attached to the C-terminus.	Asparagine	207-210	prion protein	Mus musculus	44-47
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	238-241	tubulin beta 3 class III	Homo sapiens	97-105
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	238-241	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	97-103
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	238-241	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	238-241	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	260-270	tubulin beta 3 class III	Homo sapiens	97-105
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	260-270	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	97-103
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	260-270	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2525556-9	1989	The latter activity is probably due to GlcNAc-transferase IV which preferentially adds GlcNAc in beta 1-4 linkage to the Man alpha 1-3 arm of the GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4GlcNAc-Asn core structure of asparagine-linked glycans.	Asparagine	260-270	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2587421-8	1989	Human PYY(1-36) differs from porcine PYY only at position 3, with Ile instead of Ala, and position 18, with Asn instead of Ser.	Asparagine	108-111	peptide YY	Homo sapiens	6-9
2775232-5	1989	The N-linked glycosylation points found here in platelet GPIIb are the same as the five N-glycosylated asparagine residues suggested after cDNA sequencing of human erythroleukaemic-cell GPIIb [Poncz, Eisman, Heindenreich, Silver, Vilaire, Surrey, Schwartz & Bennett (1987) J. Biol.	Asparagine	103-113	integrin subunit alpha 2b	Homo sapiens	57-62
2775232-5	1989	The N-linked glycosylation points found here in platelet GPIIb are the same as the five N-glycosylated asparagine residues suggested after cDNA sequencing of human erythroleukaemic-cell GPIIb [Poncz, Eisman, Heindenreich, Silver, Vilaire, Surrey, Schwartz & Bennett (1987) J. Biol.	Asparagine	103-113	integrin subunit alpha 2b	Homo sapiens	186-191
2569668-2	1989	This gene has now been identified as the structural gene for asparagine synthetase (AS) on the bases of sequence homology and the ability of exogenous asparagine to bypass the ts11 block.	Asparagine	61-71	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	176-180
2469609-0	1989	Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain.	Asparagine	103-113	insulin	Homo sapiens	22-29
2469609-6	1989	These findings suggest that TH-IAA is monoclonal and is directed at a determinant at B-3 (asparagine) on the human insulin B-chain.	Asparagine	90-100	insulin	Homo sapiens	115-122
2753872-1	1989	The asparagine-linked sugar chains of fibronectin purified from human placenta were quantitatively released as oligosaccharides by hydrazinolysis.	Asparagine	4-14	fibronectin 1	Homo sapiens	38-49
2568118-11	1989	Six posttranslational modifications of both PrP isoforms have been identified: (1) cleavage of an N-terminal signal peptide, (2) an intramolecular disulfide bond, (3) an N-linked oligosaccharide attached to Asn 181, (4) a second oligosaccharide attached to Asn 197, (5) cleavage of a C-terminal hydrophobic peptide, and (6) a phosphatidylinositol glycolipid attached to the C-terminus.	Asparagine	257-260	prion protein	Mus musculus	44-47
2663650-7	1989	The Asn and Lys contents of the predicted protein are exceptionally high, these residues being particularly concentrated in the DHFR and junction domains.	Asparagine	4-7	dihydrofolate reductase	Homo sapiens	128-132
2666327-8	1989	However, the third glycosylation at Asn-144 occurs only in 60% of kallikrein molecules.	Asparagine	36-39	kallikrein related peptidase 4	Homo sapiens	66-76
2725528-4	1989	The deduced amino acid sequence of the rat follistatin precursor is highly homologous (greater than 98%) to porcine and human follistatins including potential Asn-glycosylation sites.	Asparagine	159-162	follistatin	Rattus norvegicus	43-54
2659073-1	1989	The catalytically essential amino acid, histidine 176, in the active site of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been replaced with an asparagine residue by site-directed mutagenesis.	Asparagine	169-179	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	94-134
2659073-1	1989	The catalytically essential amino acid, histidine 176, in the active site of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been replaced with an asparagine residue by site-directed mutagenesis.	Asparagine	169-179	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	136-141
2701940-8	1989	A putative asparagine-linked N-glycosylation site which was conserved in the chicken vitellogenin II and the Xenopus laevis vitellogenin A2 gene, at the beginning of exon 23, is also present in vitellogenin III.	Asparagine	11-21	vitellogenin 2	Gallus gallus	85-100
2701940-8	1989	A putative asparagine-linked N-glycosylation site which was conserved in the chicken vitellogenin II and the Xenopus laevis vitellogenin A2 gene, at the beginning of exon 23, is also present in vitellogenin III.	Asparagine	11-21	vitellogenin A2 L homeolog	Xenopus laevis	124-139
2701940-8	1989	A putative asparagine-linked N-glycosylation site which was conserved in the chicken vitellogenin II and the Xenopus laevis vitellogenin A2 gene, at the beginning of exon 23, is also present in vitellogenin III.	Asparagine	11-21	a1-a	Xenopus laevis	85-97
2468312-3	1989	Although CEA molecule possesses 24 approximately 26 asparagine-linked sugar chains, which seem to cover uniformly the peptide core chain, antigenicity of sugar chains themselves is rather weak.	Asparagine	52-62	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	9-12
2732208-1	1989	One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group.	Asparagine	42-52	chorionic gonadotropin subunit beta 5	Homo sapiens	106-109
2777338-2	1989	Comparison of their amino acid sequences with those of other HLA-B-locus alleles established HLA-Bw6 to be distinguished by Ser at residue 77 and Asn at residue 80.	Asparagine	146-149	BW6	Homo sapiens	97-100
2466334-3	1989	The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues.	Asparagine	126-136	amphiregulin	Homo sapiens	27-39
2493247-1	1989	Thr-301 of cytochrome P-450 (laurate (omega-1)-hydroxylase) was replaced by Ser, Val, Ile, or Asn via site-directed mutagenesis.	Asparagine	94-97	cytochrome P-450	Oryctolagus cuniculus	11-58
2493247-2	1989	The Ser-, Val-, and Asn-mutants had lower laurate (omega-1)-hydroxylase activities than the wild-type P-450.	Asparagine	20-23	cytochrome P450 2C2	Oryctolagus cuniculus	42-71
3202875-4	1988	The differences between the structures of porcine and human PYY are at positions 3 (Ala/Ile replacement) and 18 (Ser/Asn).	Asparagine	117-120	peptide YY	Homo sapiens	60-63
2848842-2	1988	The first step in the assembly of the dolichol-linked oligosaccharides required for asparagine-linked glycosylation in eukaryotes is catalyzed by a tunicamycin-sensitive, dolichol phosphate-dependent N-acetylglucosamine-1-phosphate transferase (GPT).	Asparagine	84-94	alanine aminotransferase 1	Cricetulus griseus	245-248
2748573-3	1989	Deamidation of the labile Asn-67 residue of RNase A was followed electrophoretically and chromatographically.	Asparagine	26-29	ribonuclease A family member 1, pancreatic	Homo sapiens	44-51
3198642-12	1988	Comparison with the published nucleotide sequence for the precursor form of the human activator protein for sulfatide sulfatase (SAP-1) suggested that this activator also has a possibly glycosylated Asn and 6 Cys residues at similar positions, although the remainder of the molecule is somewhat different.	Asparagine	199-202	defensin beta 4A	Homo sapiens	129-134
3182859-0	1988	Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells.	Asparagine	25-35	interferon beta 1	Homo sapiens	73-90
2852984-2	1988	The same amino acids that have previously been reported to induce ODC in tissue culture, i.e., asparagine and glutamine, were found to produce a concentration- and time-dependent increase in ODC activity that reached a 100 fold the control value after 6 h of incubation.	Asparagine	95-105	ornithine decarboxylase 1	Rattus norvegicus	66-69
2852984-2	1988	The same amino acids that have previously been reported to induce ODC in tissue culture, i.e., asparagine and glutamine, were found to produce a concentration- and time-dependent increase in ODC activity that reached a 100 fold the control value after 6 h of incubation.	Asparagine	95-105	ornithine decarboxylase 1	Rattus norvegicus	191-194
2852984-3	1988	The effect of asparagine was totally blocked by inhibition of either protein or RNA synthesis, suggesting that the inducing amino acids increase ODC activity by stimulating the transcription of genes directly or indirectly regulating ODC activity.	Asparagine	14-24	ornithine decarboxylase 1	Rattus norvegicus	145-148
2852984-3	1988	The effect of asparagine was totally blocked by inhibition of either protein or RNA synthesis, suggesting that the inducing amino acids increase ODC activity by stimulating the transcription of genes directly or indirectly regulating ODC activity.	Asparagine	14-24	ornithine decarboxylase 1	Rattus norvegicus	234-237
2852984-6	1988	Although the opiate antagonists naloxone and naltrexone totally blocked the effects of the opioid peptides on ODC induction, they also produced an inhibition of the asparagine-mediated increase in ODC activity.	Asparagine	165-175	ornithine decarboxylase 1	Rattus norvegicus	197-200
3148445-5	1988	The rat t-PA sequence contains two putative N-glycosylation sites at Asn-120 and Asn-452, while human t-PA has an additional glycosylation site at Asn-187.	Asparagine	69-72	plasminogen activator, tissue type	Rattus norvegicus	8-12
3148445-5	1988	The rat t-PA sequence contains two putative N-glycosylation sites at Asn-120 and Asn-452, while human t-PA has an additional glycosylation site at Asn-187.	Asparagine	81-84	plasminogen activator, tissue type	Rattus norvegicus	8-12
3148445-5	1988	The rat t-PA sequence contains two putative N-glycosylation sites at Asn-120 and Asn-452, while human t-PA has an additional glycosylation site at Asn-187.	Asparagine	81-84	plasminogen activator, tissue type	Rattus norvegicus	8-12
3141586-5	1988	Endo-beta-N-acetylglucosaminidase F digestion of P400 protein revealed that P400 protein has a small number of asparagine-linked oligosaccharide chains and that the epitope that is recognized by 18A10 monoclonal antibody is not on the asparagine-linked oligosaccharide portion.	Asparagine	111-121	E1A binding protein p400	Mus musculus	49-53
3141586-5	1988	Endo-beta-N-acetylglucosaminidase F digestion of P400 protein revealed that P400 protein has a small number of asparagine-linked oligosaccharide chains and that the epitope that is recognized by 18A10 monoclonal antibody is not on the asparagine-linked oligosaccharide portion.	Asparagine	111-121	E1A binding protein p400	Mus musculus	76-80
3141586-5	1988	Endo-beta-N-acetylglucosaminidase F digestion of P400 protein revealed that P400 protein has a small number of asparagine-linked oligosaccharide chains and that the epitope that is recognized by 18A10 monoclonal antibody is not on the asparagine-linked oligosaccharide portion.	Asparagine	235-245	E1A binding protein p400	Mus musculus	49-53
3141586-5	1988	Endo-beta-N-acetylglucosaminidase F digestion of P400 protein revealed that P400 protein has a small number of asparagine-linked oligosaccharide chains and that the epitope that is recognized by 18A10 monoclonal antibody is not on the asparagine-linked oligosaccharide portion.	Asparagine	235-245	E1A binding protein p400	Mus musculus	76-80
2852984-7	1988	Other factors like dibutyryl cyclic AMP and insulin also potentiated the effects of asparagine on ODC activity.	Asparagine	84-94	ornithine decarboxylase 1	Rattus norvegicus	98-101
3182868-7	1988	The asparagine-linked structures at Asn-419, but not those at Asn-432, are resistant to endo-beta-N-acetylglucosaminidase H within 30 s of biosynthesis.	Asparagine	4-14	O-GlcNAcase	Homo sapiens	93-121
3182868-7	1988	The asparagine-linked structures at Asn-419, but not those at Asn-432, are resistant to endo-beta-N-acetylglucosaminidase H within 30 s of biosynthesis.	Asparagine	36-39	O-GlcNAcase	Homo sapiens	93-121
3182859-0	1988	Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells.	Asparagine	25-35	interferon beta 1	Homo sapiens	113-130
3182859-1	1988	The asparagine-linked sugar chains of natural interferon-beta 1 secreted from human foreskin fibroblasts by poly I:poly C induction and of three recombinant human interferon-beta 1 produced by Chinese hamster ovary cells, mouse epithelial cells (C127), and human lung adenocarcinoma cells (PC8) were released quantitatively as oligosaccharides by hydrazinolysis followed by N-acetylation.	Asparagine	4-14	interferon beta 1	Homo sapiens	46-63
3147904-8	1988	From that we deduce that the hepatic synthesis of the plasma proteins might be influenced by asparagine and glutamine depletion as a consequence of the therapy with E. coli asparaginase.	Asparagine	93-103	asparaginase	Homo sapiens	173-185
3264157-3	1988	EGF also stimulated gluconeogenesis from lactate and asparagine, but not from glutamine or from proline.	Asparagine	53-63	epidermal growth factor like 1	Rattus norvegicus	0-3
3145192-7	1988	This phenotype was caused by a single chromosomal mutation, leading to the replacement of aspartic acid 40 of the RAS2 protein by asparagine.	Asparagine	130-140	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	114-118
3053963-7	1988	There are three potential asparagine-linked glycosylation sites in MCSP-1 and MCSP-3, and four in MCSP-2-deduced amino acid sequences.	Asparagine	26-36	granzyme G	Mus musculus	67-73
3053963-7	1988	There are three potential asparagine-linked glycosylation sites in MCSP-1 and MCSP-3, and four in MCSP-2-deduced amino acid sequences.	Asparagine	26-36	granzyme F	Mus musculus	78-84
3264877-5	1988	Digestion with glycosidic enzymes indicated that soluble CSF-1 encoded by the 4-kb cDNA contained both asparagine(N)-linked and O-linked carbohydrate chains, whereas the product of the 1.6-kb clone had only N-linked oligosaccharides.	Asparagine	103-113	colony stimulating factor 1	Homo sapiens	57-62
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Asparagine	103-106	calmodulin 1	Homo sapiens	224-234
2971654-0	1988	Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.	Asparagine	45-55	transforming growth factor beta-1 proprotein	Cricetulus griseus	91-124
2971654-3	1988	Fractionation of 32P-labeled glycopeptides followed by amino acid sequence analysis indicated that greater than 95% of the label was incorporated into two out of three glycosylation sites at Asn-82 and Asn-136 of the TGF-beta 1 precursor.	Asparagine	191-194	transforming growth factor beta-1 proprotein	Cricetulus griseus	217-227
2971654-3	1988	Fractionation of 32P-labeled glycopeptides followed by amino acid sequence analysis indicated that greater than 95% of the label was incorporated into two out of three glycosylation sites at Asn-82 and Asn-136 of the TGF-beta 1 precursor.	Asparagine	202-205	transforming growth factor beta-1 proprotein	Cricetulus griseus	217-227
3196309-4	1988	Previously determined amino acid sequences of two 150-residue molecules, PRP-1 and PRP-2, and two related 106-residue proteins, PRP-3 and PRP-4, indicated that residue 4 was Asn in PRP-1 and PRP-3, and Asp in PRP-2 and PRP-4, and position 50 was Asn in all four proteins.	Asparagine	174-177	transmembrane protein 171	Homo sapiens	83-88
3196309-4	1988	Previously determined amino acid sequences of two 150-residue molecules, PRP-1 and PRP-2, and two related 106-residue proteins, PRP-3 and PRP-4, indicated that residue 4 was Asn in PRP-1 and PRP-3, and Asp in PRP-2 and PRP-4, and position 50 was Asn in all four proteins.	Asparagine	174-177	pre-mRNA processing factor 3	Homo sapiens	128-133
3196309-4	1988	Previously determined amino acid sequences of two 150-residue molecules, PRP-1 and PRP-2, and two related 106-residue proteins, PRP-3 and PRP-4, indicated that residue 4 was Asn in PRP-1 and PRP-3, and Asp in PRP-2 and PRP-4, and position 50 was Asn in all four proteins.	Asparagine	174-177	pre-mRNA processing factor 4B	Homo sapiens	138-143
2459697-2	1988	Replacement of Asp-116 in angiogenin by either asparagine (D116N), alanine (D116A), or histidine (D116H) markedly enhances both its ribonucleolytic activity and angiogenic potency.	Asparagine	47-57	ribonuclease A family member k6	Gallus gallus	26-36
2844182-0	1988	Possible role of the membrane Na+/H+ antiport in ornithine decarboxylase induction by L-asparagine.	Asparagine	86-98	ornithine decarboxylase 1	Rattus norvegicus	49-72
2844182-6	1988	The induction of ornithine decarboxylase by L-asparagine was also amiloride-sensitive.	Asparagine	44-56	ornithine decarboxylase 1	Rattus norvegicus	17-40
3410855-1	1988	Substitution of glutamine for asparagine 293 in chicken ovalbumin does not allow glycosylation of asparagine 312.	Asparagine	30-40	ovalbumin (SERPINB14)	Gallus gallus	56-65
3065149-6	1988	Variants of PSTI with Asp or Asn at aa positions 21 and 29 [sequences published by Greene et al., Methods Enzymol.	Asparagine	29-32	serine peptidase inhibitor Kazal type 1	Homo sapiens	12-16
2902877-1	1988	Asparagine-linked sugar chains of rat kidney aminopeptidase N and dipeptidylpeptidase IV were investigated comparatively.	Asparagine	0-10	alanyl aminopeptidase, membrane	Rattus norvegicus	45-61
2850146-2	1988	TGF-beta 2,442 contains a 29-amino-acid insertion in the amino terminus of the precursor region that replaces an Asn residue located at position 116 in TGF-beta 2,414.	Asparagine	113-116	transforming growth factor beta 2	Homo sapiens	0-10
2850146-2	1988	TGF-beta 2,442 contains a 29-amino-acid insertion in the amino terminus of the precursor region that replaces an Asn residue located at position 116 in TGF-beta 2,414.	Asparagine	113-116	transforming growth factor beta 2	Homo sapiens	152-162
2839508-2	1988	While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH.	Asparagine	156-159	uncharacterized protein	Drosophila melanogaster	129-135
2848546-1	1988	beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III (GlcNAc-T III) catalyzes the incorporation of a "bisecting" N-acetylglucosamine (GlcNAc) residue in beta 1-4 linkage to the beta-linked mannose of the core of asparagine linked-protein bound oligosaccharides (N-glycans).	Asparagine	235-245	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-75
2848546-1	1988	beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III (GlcNAc-T III) catalyzes the incorporation of a "bisecting" N-acetylglucosamine (GlcNAc) residue in beta 1-4 linkage to the beta-linked mannose of the core of asparagine linked-protein bound oligosaccharides (N-glycans).	Asparagine	235-245	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	77-89
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	Asparagine	63-73	lysosomal-associated membrane protein 1	Mus musculus	102-105
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	Asparagine	63-73	fibronectin 1	Mus musculus	153-164
3145408-3	1988	The inhibitory effect of Asn-17 p21 required its localization to the plasma membrane and was reversed by coexpression of an activated ras gene, indicating that the mutant p21 blocked the endogenous ras function required for NIH 3T3 cell proliferation.	Asparagine	25-28	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	32-35
3145408-3	1988	The inhibitory effect of Asn-17 p21 required its localization to the plasma membrane and was reversed by coexpression of an activated ras gene, indicating that the mutant p21 blocked the endogenous ras function required for NIH 3T3 cell proliferation.	Asparagine	25-28	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	171-174
3383775-8	1988	Peptide-N-glycosidase treatment of USP-1 induced by E2 or tamoxifen removed asparagine-linked carbohydrate chains and resulted in the appearance of polypeptides with apparent mol wt of 91K and 105K, respectively.	Asparagine	76-86	ubiquitin specific peptidase 1	Rattus norvegicus	35-40
3379062-4	1988	The smallest immunoreactive VIP was purified by ion-exchange and reverse-phase high-performance liquid chromatography, and the amino acid sequence was determined to be that of VIP10-28 with asparagine-free acid at the carboxyl terminus rather than the amide of VIP neuropeptide.	Asparagine	190-200	vasoactive intestinal peptide	Rattus norvegicus	28-31
3379062-4	1988	The smallest immunoreactive VIP was purified by ion-exchange and reverse-phase high-performance liquid chromatography, and the amino acid sequence was determined to be that of VIP10-28 with asparagine-free acid at the carboxyl terminus rather than the amide of VIP neuropeptide.	Asparagine	190-200	vasoactive intestinal peptide	Rattus norvegicus	176-179
3290901-6	1988	SW480 human colon carcinoma cells transfected with the Asn-25 mutant proviral DNA produced virions that contained gag p55 but not gag p24, whereas virions from cells transfected with the wild-type DNA contained both gag p55 and gag p24.	Asparagine	55-58	H3 histone pseudogene 44	Homo sapiens	118-121
3072564-5	1988	However, acid solutions of insulin are chemically unstable as A21 asparagine both deamidates to aspartic acid and takes part in formation of covalent dimers via alpha-amino groups of other molecules.	Asparagine	66-76	insulin	Sus scrofa	27-34
3290901-6	1988	SW480 human colon carcinoma cells transfected with the Asn-25 mutant proviral DNA produced virions that contained gag p55 but not gag p24, whereas virions from cells transfected with the wild-type DNA contained both gag p55 and gag p24.	Asparagine	55-58	H3 histone pseudogene 44	Homo sapiens	220-223
3290901-6	1988	SW480 human colon carcinoma cells transfected with the Asn-25 mutant proviral DNA produced virions that contained gag p55 but not gag p24, whereas virions from cells transfected with the wild-type DNA contained both gag p55 and gag p24.	Asparagine	55-58	transmembrane p24 trafficking protein 2	Homo sapiens	232-235
3379044-11	1988	U.S.A. 85, in press) and the mouse gp130 (P2B) glycoprotein, in which an increase in beta 1-6 branching of asparagine-linked oligosaccharides has been correlated with metastatic potential in certain tumor cells (Dennis, J.W., Laferte, S., Waghorne, C., Breitman, M.L., and Kerbel, R.S.	Asparagine	107-117	hemoglobin, beta adult major chain	Mus musculus	85-93
3288503-1	1988	One or both of two putative N-glycosylation sites (at asparagine-5 and -75) of human renin was eliminated by amino acid replacement of the asparagine residue with an alanine residue using site-directed mutagenesis.	Asparagine	54-64	renin	Homo sapiens	85-90
3170515-2	1988	A comparative study of the oligosaccharides released from the two subunits by hydrazinolysis revealed that altered glycosylation occurs in both subunits and possibly at all four asparagine sites of the choriocarcinoma hCG molecule.	Asparagine	178-188	chorionic gonadotropin subunit beta 5	Homo sapiens	218-221
3288503-1	1988	One or both of two putative N-glycosylation sites (at asparagine-5 and -75) of human renin was eliminated by amino acid replacement of the asparagine residue with an alanine residue using site-directed mutagenesis.	Asparagine	139-149	renin	Homo sapiens	85-90
3360773-1	1988	An accumulation of Man9,8-GlcNAc2-Asn species is indicative of an impaired N-glycan trimming in undifferentiated cells.	Asparagine	34-37	mannosidase alpha class 1A member 1	Homo sapiens	19-23
3366781-3	1988	Incubation of A431 cells with this inhibitor of asparagine-linked glycosylation results in a shift of the apparent molecular weight of the transferrin receptor from 94,000 to 79,000.	Asparagine	48-58	transferrin	Homo sapiens	139-150
2843830-2	1988	It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg.	Asparagine	70-80	vasoactive intestinal peptide	Homo sapiens	90-93
2839526-3	1988	hCG contains five acidic asparagine-linked sugar chains.	Asparagine	25-35	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
2839526-7	1988	This specific distribution of oligosaccharides at the four asparagine loci of the hCG molecule is now helping us to consider the functional role of the sugar moiety of glycohormones.	Asparagine	59-69	chorionic gonadotropin subunit beta 5	Homo sapiens	82-85
2966206-8	1988	Chemical deglycosylation with trifluoromethanesulfonic acid, which cleaves O- and N-linked oligosaccharides except for the asparagine-linked N-acetylglucosamine, reduced the Mr of Fc gamma RIII to 21 to 36 kDa.	Asparagine	123-133	Fc gamma receptor IIIa	Homo sapiens	180-193
2981047-1	1988	Ascites hepatoma AH-66 and 3"-Me-DAB-induced hepatoma of rats contain highly active N-acetylglucosaminyltransferase III (GnT-III) which catalyzes the addition of N-acetylglucosamine through a beta 1-4 linkage (bisecting N-acetylglucosamine) to the beta-linked mannose of the trimannosyl core of asparagine-linked sugar chains, whereas normal rat liver contains very little.	Asparagine	295-305	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	84-119
2965705-4	1988	N-Acetylglucosaminyltransferase I gave a 100-fold decrease in Vmax/Km for the avidin complex of Man5GlcNAc2-(biotinyl)Asn as compared to the free glycan derivative; the rate difference reflects a large (25x) decrease in the Vmax and a relatively small increase (4x) in Km.	Asparagine	118-121	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	0-33
2981047-1	1988	Ascites hepatoma AH-66 and 3"-Me-DAB-induced hepatoma of rats contain highly active N-acetylglucosaminyltransferase III (GnT-III) which catalyzes the addition of N-acetylglucosamine through a beta 1-4 linkage (bisecting N-acetylglucosamine) to the beta-linked mannose of the trimannosyl core of asparagine-linked sugar chains, whereas normal rat liver contains very little.	Asparagine	295-305	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	121-128
3127394-5	1988	PAI-2 is variably glycosylated on asparagine residues to yield intracellular intermediates with zero, one, two, or three high mannose-type oligosaccharide units.	Asparagine	34-44	serpin family B member 2	Homo sapiens	0-5
3355844-1	1988	Rat liver glycosylasparaginase (N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase (EC 3.5.1.26) was irreversibly inhibited in vitro by the asparagine analogue 5-diazo-4-oxo-L-norvaline (DONV).	Asparagine	68-78	aspartylglucosaminidase	Rattus norvegicus	10-30
3390164-10	1988	Bovine IGF-2 was found to differ in three residues of the C-domain compared with human IGF-2, with serine, isoleucine and asparagine substituted for alanine, valine and serine respectively at positions 32, 35 and 36.	Asparagine	122-132	insulin like growth factor 2	Bos taurus	7-12
2452167-2	1988	Site-directed mutagenesis of the two asparagine-linked glycosylation sites of hCG alpha was used to study the function of the individual oligosaccharide chains in secretion and subunit assembly.	Asparagine	37-47	chromogranin A	Homo sapiens	78-87
2453751-1	1988	The pharmacokinetics and thrombolytic properties of a variant of human tissue-type plasminogen activator (t-PA), obtained by deletion mutagenesis of the NH2-terminal fibronectin-like finger (F) and epidermal growth factor (E) domains, and substitution of the three known glycosylated Asn residues by Gln (t-PA-delta FE3X), were studied in dogs with a copper coil-induced thrombosis of the left anterior descending coronary artery.	Asparagine	284-287	plasminogen activator, tissue type	Homo sapiens	106-110
3257825-6	1988	In codon 172 of the mutant gene, the normal codon ATC, encoding isoleucine, has been changed to AAC, encoding asparagine.	Asparagine	110-120	glycine-N-acyltransferase	Homo sapiens	96-99
3346214-1	1988	The asparagine-linked sugar chains of human erythropoietin produced by recombinant Chinese hamster ovary cells and naturally occurring human urinary erythropoietin were liberated by hydrazinolysis and fractionated by paper electrophoresis, lectin affinity chromatography, and Bio-Gel P-4 column chromatography.	Asparagine	4-14	erythropoietin	Homo sapiens	44-58
3346214-1	1988	The asparagine-linked sugar chains of human erythropoietin produced by recombinant Chinese hamster ovary cells and naturally occurring human urinary erythropoietin were liberated by hydrazinolysis and fractionated by paper electrophoresis, lectin affinity chromatography, and Bio-Gel P-4 column chromatography.	Asparagine	4-14	erythropoietin	Homo sapiens	149-163
3367907-5	1988	Expression of mutants of NB lacking either one or both of the normal N-terminal sites of asparagine-linked glycosylation indicated that both carbohydrate chains are modified to contain polylactosaminoglycan.	Asparagine	89-99	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	25-27
2835049-0	1988	The induction of ornithine decarboxylase by L-asparagine and intracellular alkalinization.	Asparagine	44-56	ornithine decarboxylase 1	Homo sapiens	17-40
2835049-1	1988	The uptake of transport systems A and N amino acids, most noticeably L-asparagine, is essential for the induction of ornithine decarboxylase (L-ornithine carboxylase, EC 4.1.1.17) in cultured cells and we have proposed that the uptake-associated pH and ionic changes might constitute part of the cell activation signal (1).	Asparagine	69-81	ornithine decarboxylase 1	Homo sapiens	117-140
2447246-5	1988	When the racemization was examined in terms of the beta-structure model of MBP, a correlation was observed in which six aspartate/asparagine residues assumed to be associated with myelin membrane lipids showed little racemization (2.2-4.9% D isomer), whereas five other aspartate residues were more highly racemized (9.9-17.1% D isomer).	Asparagine	130-140	myelin basic protein	Homo sapiens	75-78
3066670-9	1988	Substituting an alanine, asparagine, aspartic acid, or serine at residue 125 resulted in highly active molecules with CTLL activities similar to that of the natural recombinant IL-2.	Asparagine	25-35	interleukin 2	Homo sapiens	177-181
3130349-1	1988	Datura stramonium agglutinin (DSA) binds the asparagine-linked sugar chains commonly found in the human chorionic gonadotropin (hCG) purified from urine of patients with invasive mole or choriocarcinoma, but not in that of normal pregnant women or patients with hydatidiform mole.	Asparagine	45-55	chorionic gonadotropin subunit beta 5	Homo sapiens	104-132
3275655-8	1988	By relating the NH2-terminal amino acid sequences of these peptides to the sequence of the intact egg-specific protein, the protease was shown to cleave first at a Lys-Asn site and secondly at Arg-Asp.	Asparagine	168-171	egg-specific protein	Bombyx mori	98-118
3693352-5	1987	Furthermore, substitution of the Ser with L-Asn resulted in a peptide that had an apparent increased preference for the fibronectin receptor and decreased preference for the vitronectin receptor.	Asparagine	42-47	fibronectin 1	Homo sapiens	120-131
3384705-1	1988	A murine hybridoma was generated which secreted a monoclonal antibody (Mab) that specifically recognized the alpha 2(68)(E17)Asn----Lys beta 2 substitution of Hb G-Philadelphia.	Asparagine	125-128	hemoglobin, beta adult minor chain	Mus musculus	136-142
3693352-5	1987	Furthermore, substitution of the Ser with L-Asn resulted in a peptide that had an apparent increased preference for the fibronectin receptor and decreased preference for the vitronectin receptor.	Asparagine	42-47	vitronectin	Homo sapiens	174-185
3316217-7	1987	The CETP peptide acquires asparagine-linked carbohydrate and sialic acid during intracellular processing.	Asparagine	26-36	cholesteryl ester transfer protein	Homo sapiens	4-8
2830253-4	1987	The sequence of Ch1 has three substitutions from that of turkey muscle acylphosphatase; these are Ser from Ala at position 9, Ser from Arg at 47, and Lys from Asn at 83.	Asparagine	159-162	SUN domain containing ossification factor	Gallus gallus	16-19
3322394-3	1987	We have synthesized [21-asparagine diethylamide-A]insulin, which differs from the parent molecule in that the free carboxyl group of the C-terminal amino acid residue, asparagine, of the A chain moiety has been converted to a diethylamide group.	Asparagine	24-34	insulin	Bos taurus	50-57
3427074-6	1987	Computer modeling studies using the amino acid sequence of elastase 2 superimposed on the X-ray structure of porcine elastase 1 suggest that a change of Gln-192 in elastase 1 to Asn-192 in elastase 2 may account for the lower catalytic efficiency of the latter enzyme.	Asparagine	178-181	elastase, neutrophil expressed	Homo sapiens	59-69
3427074-6	1987	Computer modeling studies using the amino acid sequence of elastase 2 superimposed on the X-ray structure of porcine elastase 1 suggest that a change of Gln-192 in elastase 1 to Asn-192 in elastase 2 may account for the lower catalytic efficiency of the latter enzyme.	Asparagine	178-181	chymotrypsin like elastase 3A	Homo sapiens	117-127
3427074-6	1987	Computer modeling studies using the amino acid sequence of elastase 2 superimposed on the X-ray structure of porcine elastase 1 suggest that a change of Gln-192 in elastase 1 to Asn-192 in elastase 2 may account for the lower catalytic efficiency of the latter enzyme.	Asparagine	178-181	chymotrypsin like elastase 3A	Homo sapiens	164-174
3427074-6	1987	Computer modeling studies using the amino acid sequence of elastase 2 superimposed on the X-ray structure of porcine elastase 1 suggest that a change of Gln-192 in elastase 1 to Asn-192 in elastase 2 may account for the lower catalytic efficiency of the latter enzyme.	Asparagine	178-181	elastase, neutrophil expressed	Homo sapiens	189-199
3446582-2	1987	The amino acid substitution of Asp in the variant G6PD A(+) for Asn in the normal G6PD B(+) was previously found (A. Yoshida, 1967, Proc.	Asparagine	64-67	glucose-6-phosphate dehydrogenase	Homo sapiens	50-54
3446582-2	1987	The amino acid substitution of Asp in the variant G6PD A(+) for Asn in the normal G6PD B(+) was previously found (A. Yoshida, 1967, Proc.	Asparagine	64-67	glucose-6-phosphate dehydrogenase	Homo sapiens	82-86
3672035-1	1987	The hydrophilic nonapeptide Ser-Asp-Ala-Arg-Glu-Asn-Ile-Gln-Arg, identical with residues 59-67 of human amyloid protein A (AA) and serum amyloid protein A (SAA), was covalently bound via its carboxyl-terminal end to the carrier-protein keyhole limpet haemocyanin.	Asparagine	48-51	serum amyloid A1 cluster	Homo sapiens	156-159
2820791-5	1987	Amino acid analysis, sequential Edman degradation and FAB-MS of this peptide indicate that the residue at position 150 is an erythro-beta-hydroxyasparagine resulting from post-translational hydroxylation of asparagine.	Asparagine	145-155	FA complementation group B	Homo sapiens	54-57
3667604-0	1987	Molecular mechanisms of the synergistic induction of ornithine decarboxylase by asparagine and glucagon in primary cultured hepatocytes.	Asparagine	80-90	ornithine decarboxylase 1	Rattus norvegicus	53-76
3667604-1	1987	In primary cultures of adult rat hepatocytes maintained in a salts/glucose medium, a more than 100-fold increase in ornithine decarboxylase (EC 4.1.1.17) activity was caused by asparagine and glucagon in a synergistic manner.	Asparagine	177-187	ornithine decarboxylase 1	Rattus norvegicus	116-139
3667604-3	1987	The synthesis rate of ornithine decarboxylase was stimulated more than 20-fold by asparagine and glucagon together, but the amount of ornithine decarboxylase-mRNA was increased only 3-4-fold, indicating that translational stimulation was involved in the induction process.	Asparagine	82-92	ornithine decarboxylase 1	Rattus norvegicus	22-45
3667604-4	1987	Asparagine alone stimulated the synthesis of ornithine decarboxylase without substantial effect on the amount of ornithine decarboxylase-mRNA, whereas glucagon alone increased the amount of ornithine decarboxylase-mRNA about 3-fold without a detectable change in either enzyme activity or enzyme synthesis.	Asparagine	0-10	ornithine decarboxylase 1	Rattus norvegicus	45-68
3667604-5	1987	Asparagine, at least in part, also suppressed degradation of ornithine decarboxylase.	Asparagine	0-10	ornithine decarboxylase 1	Rattus norvegicus	61-84
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Asparagine	193-196	interleukin 1 alpha	Homo sapiens	60-70
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Asparagine	193-196	interleukin 1 alpha	Homo sapiens	177-187
3663221-1	1987	N-glycanase, an endoglycosidase that cleaves the bond between asparagine and glucosamine, releases oligosaccharides with various degree of sulfation from endothelial cell fibronectin.	Asparagine	62-72	fibronectin 1	Homo sapiens	171-182
3624258-1	1987	Modification of calmodulin by protein carboxyl methyltransferase requires deamidation of one or more labile asparagine residues (Johnson, B.A., Freitag, N. E., and Aswad, D. W. (1985) J. Biol.	Asparagine	108-118	calmodulin 1	Rattus norvegicus	16-26
3662531-1	1987	The asparagine-linked sugar chains of mouse immunoglobulin G (IgG) were quantitatively liberated as radioactive oligosaccharides from the polypeptide portions by hydrazinolysis followed by N-acetylation, and NaB3H4 reduction.	Asparagine	4-14	immunoglobulin heavy variable V1-62	Mus musculus	44-60
3662531-1	1987	The asparagine-linked sugar chains of mouse immunoglobulin G (IgG) were quantitatively liberated as radioactive oligosaccharides from the polypeptide portions by hydrazinolysis followed by N-acetylation, and NaB3H4 reduction.	Asparagine	4-14	immunoglobulin heavy variable V1-62	Mus musculus	62-65
2444130-8	1987	Glycoasparagine, lacking all amino acids except the carbohydrate-linking asparagine, inhibits IgE-binding to glycopeptide discs up to 100%.	Asparagine	5-15	immunoglobulin heavy constant epsilon	Homo sapiens	94-97
3676250-2	1987	After IgG affinity purification of the fusion proteins from the growth medium of Staphylococcus aureus or Escherichia coli, native IGF-I was released by cleavage of an Asn-Gly peptide bond with hydroxylamine.	Asparagine	168-171	insulin like growth factor 1	Homo sapiens	131-136
3603027-5	1987	The ornithine transcarbamylase gene in the sparse fur mouse contains a C to A transversion that alters a histidine residue to an asparagine residue at amino acid 117.	Asparagine	129-139	ornithine transcarbamylase	Mus musculus	4-30
2464379-5	1987	The synthetic hPTH 1-84 (Asn 76) and the native hormone behaved similarly in all four assays which were specific to the amino-, mid- and carboxy-regions of human parathyroid hormone.	Asparagine	25-28	parathyroid hormone	Homo sapiens	14-20
2464379-9	1987	It is concluded that synthetic hPTH 1-84 (Asn 76) is a satisfactory standard for the immunoassay of human parathyroid hormone and is useful as a radioligand when labelled with 125I.	Asparagine	42-45	parathyroid hormone	Homo sapiens	31-37
3609301-0	1987	Physiological variant of antithrombin-III lacks carbohydrate sidechain at Asn 135.	Asparagine	74-77	serpin family C member 1	Homo sapiens	25-41
3036276-4	1987	Addition of a Thr to the carboxy-terminus and an Asn to the amino-terminus of the RGDS sequence, the amino acids corresponding to A alpha 576 and 571 respectively, reduced the inhibitory potency of RGDS-containing peptides by fourfold to tenfold.	Asparagine	49-52	ral guanine nucleotide dissociation stimulator	Homo sapiens	82-86
3609301-5	1987	Chromatography of total tryptic digests on concanavalin A-Sepharose confirmed that the high heparin affinity form of antithrombin lacked an oligosaccharide moiety at Asn 135.	Asparagine	166-169	serpin family C member 1	Homo sapiens	117-129
3036276-4	1987	Addition of a Thr to the carboxy-terminus and an Asn to the amino-terminus of the RGDS sequence, the amino acids corresponding to A alpha 576 and 571 respectively, reduced the inhibitory potency of RGDS-containing peptides by fourfold to tenfold.	Asparagine	49-52	ral guanine nucleotide dissociation stimulator	Homo sapiens	198-202
3332544-0	1987	Expression of human interferon alpha H, an interferon with two potential asparagine-linked glycosylation sites.	Asparagine	73-83	interferon alpha 14	Homo sapiens	20-38
3581081-2	1987	The asparagine-linked sugar chains of carcinoembryonic antigens (CEA) were released as oligosaccharides by hydrazinolysis and the structures of oligosaccharides, thus obtained, was studied in combination with methylation analysis and several limited exoglycosidase digestions.	Asparagine	4-14	CEA cell adhesion molecule 3	Homo sapiens	38-63
3581081-2	1987	The asparagine-linked sugar chains of carcinoembryonic antigens (CEA) were released as oligosaccharides by hydrazinolysis and the structures of oligosaccharides, thus obtained, was studied in combination with methylation analysis and several limited exoglycosidase digestions.	Asparagine	4-14	CEA cell adhesion molecule 3	Homo sapiens	65-68
3497890-1	1987	Alpha-1-protease inhibitor, (alpha-1-PI), the major inhibitor of serine proteases in human plasma, has three asparagine-linked carbohydrate chains located at positions 46, 83 and 247.	Asparagine	109-119	serpin family A member 1	Homo sapiens	0-26
3314270-1	1987	It has been demonstrated that A-chain of insulin in the salmon O. keta consists of 21 amino acid residues with N-terminal glycine and C-terminal asparagine.	Asparagine	145-155	insulin	Canis lupus familiaris	41-48
2436653-9	1987	A four-residue basic sequence (Arg-Ser-Lys-Arg) was identified upstream of the amino-terminal Asn of C5a, thereby specifying a beta alpha-chain orientation for the promolecule form of murine C5.	Asparagine	94-97	hemolytic complement	Mus musculus	101-104
2953071-1	1987	Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-).	Asparagine	195-205	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	153-161
2953071-1	1987	Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-).	Asparagine	195-205	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2953071-1	1987	Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-).	Asparagine	207-210	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	153-161
2953071-1	1987	Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-).	Asparagine	207-210	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-159
2953071-1	1987	Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-).	Asparagine	207-210	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	254-260
3453895-7	1987	Unlike the human and porcine sequences, rat preprogastrin contains a 9 amino acid carboxy-terminal extension peptide (-Ser-Ala-Glu-Glu-Glu-Asp-Gln-Tyr-Asn) which is homologous to the midportion of gastrin 17 including the site of tyrosine sulfation.	Asparagine	151-154	gastrin	Homo sapiens	50-57
3453089-1	1987	A number of amino acids, most noticeably asparagine, were capable of inducing ornithine decarboxylase in H-35 rat hepatoma cells.	Asparagine	41-51	ornithine decarboxylase 1	Rattus norvegicus	78-101
3453089-2	1987	The effective amino acids were all neutral and were substrates of the Na+-dependent transport systems A, ASC and N. Transport inhibitor studies indicated that there was an excellent correlation between the level of enzyme activity induced and the initial rate of asparagine transport into the cells by the A and the N systems.	Asparagine	263-273	PYD and CARD domain containing	Rattus norvegicus	105-108
3550437-6	1987	These and other data suggest that the asparagine residue may play a critical role in the conformation of the HLA heavy chain and its interaction with beta 2-microglobulin.	Asparagine	38-48	beta-2-microglobulin	Homo sapiens	150-170
3567158-3	1987	Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of the abnormal thrombin indicated that Arg-418 (equivalent to Asn-101 in the chymotrypsin numbering system) had been replaced by Trp.	Asparagine	148-151	coagulation factor II, thrombin	Homo sapiens	101-109
3030286-3	1986	J., in the press] located in the C1r A-chain, within an epidermal-growth-factor consensus sequence, was found to be encoded as asparagine.	Asparagine	127-137	complement C1r	Homo sapiens	33-36
3315863-2	1987	Three asparagine residues in alpha-AT are glycosylated with the mammalian "complex" pattern of carbohydrate as the protein is secreted from cells in the liver.	Asparagine	6-16	serpin family A member 1	Homo sapiens	29-37
3315863-9	1987	Examination of alpha-AT secreted from an mnn9 mutant, which blocks addition of variable numbers of outer mannose chains, revealed a homogeneous alpha-AT product which, like alpha-AT isolated from human serum, bears carbohydrate on three asparagine residues per molecule.	Asparagine	237-247	serpin family A member 1	Homo sapiens	144-152
3315863-9	1987	Examination of alpha-AT secreted from an mnn9 mutant, which blocks addition of variable numbers of outer mannose chains, revealed a homogeneous alpha-AT product which, like alpha-AT isolated from human serum, bears carbohydrate on three asparagine residues per molecule.	Asparagine	237-247	serpin family A member 1	Homo sapiens	144-152
2432837-11	1986	Additionally, hydroxylamine cleavage of an Asn-Gly bond in prefetuin localized one of the N-linked carbohydrate side chains to the middle of the polypeptide chain of native fetuin.	Asparagine	43-46	alpha-2-HS-glycoprotein	Oryctolagus cuniculus	62-68
3771139-10	1986	The formation of this material is apparently a consequence of a deficiency in newly synthesized, asparagine-linked membrane glycoconjugates (e.g., the oligosaccharide chains of opsin) at the site of disc assembly.	Asparagine	97-107	rhodopsin, gene2 L homeolog	Xenopus laevis	177-182
3536883-5	1986	When present in fourfold molar excess, the biologically inactive desTrp-1,Ala-3 dodecapeptide reversed activity of the Asn-5,Arg-7 and Gln-5,Lys-7 tridecapeptides.	Asparagine	119-122	copper chaperone CCS1	Saccharomyces cerevisiae S288C	141-146
3740839-1	1986	The effects of pH, temperature, buffer ion, ionic strength, protein concentration, and substrate on the rates of specific, spontaneous deamidations of Asn-15 and Asn-71 of human triosephosphate isomerase were examined.	Asparagine	151-154	triosephosphate isomerase 1	Homo sapiens	178-203
2430793-9	1986	The amino acid sequence of mature PAI includes three potential asparagine-linked glycosylation sites and lacks cysteine residues.	Asparagine	63-73	serpin family E member 1	Bos taurus	34-37
3014531-2	1986	Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities of p21.	Asparagine	52-62	eukaryotic translation elongation factor 1 alpha 1	Mus musculus	116-136
3014531-2	1986	Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities of p21.	Asparagine	52-62	eukaryotic translation elongation factor 1 alpha 1	Mus musculus	138-143
3014531-2	1986	Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities of p21.	Asparagine	52-62	transcription elongation factor A (SII)-like 1	Mus musculus	246-249
3087774-3	1986	Two peptides only contained glucosamine, Unambiguous sequence analyses identified Asn-63 of the beta-chain and Asn-268 of the alpha-chain as the sites of carbohydrate attachment.	Asparagine	111-114	Fc gamma receptor and transporter	Homo sapiens	126-137
3084472-5	1986	Such a novel enzyme would therefore catalyze cleavage of the N-acetylglucosamine residue at the reducing end of alpha 1-acid glycoprotein oligosaccharides only following removal of the linking Asn.	Asparagine	193-196	orosomucoid 1	Rattus norvegicus	112-137
3790092-12	1986	Exposure of calmodulin to elevated temperatures before methylation results in racemization of aspartate and/or asparagine residues, and may result in isoaspartate formation as well.	Asparagine	111-121	calmodulin 1	Homo sapiens	12-22
3745142-6	1986	alpha 2-Plasmin inhibitor and its 65K-daltons derivative were found to have the same NH2-terminal sequence of Asn(Asp)-Gln-Glu-Gln-.	Asparagine	110-113	serpin family F member 2	Homo sapiens	0-25
3332019-4	1986	The predicted primary protein product of the int-1 gene is 370 amino acids in length and cysteine-rich; immunoprecipitation with anti-peptide antibodies reveals multiple species of int-1 protein, due to asparagine-linked glycosylations and probable cleavage of a signal peptide.	Asparagine	203-213	Wnt family member 1	Homo sapiens	45-50
3702459-3	1986	The dimeric SHBG molecule appears to contain only approximately 8% carbohydrate, and sequence information indicates that an N-linked oligosaccharide chain may be attached to residue 7 (asparagine) from the NH2-terminal amino acid (leucine).	Asparagine	185-195	sex hormone binding globulin	Homo sapiens	12-16
3948865-1	1986	Changes in both synthesis rate and degradation rate of ornithine decarboxylase (ODC) were pursued in primary cultures of adult rat hepatocytes during the process of ODC induction caused by asparagine and glucagon and also during the process of rapid ODC decay caused by putrescine.	Asparagine	189-199	ornithine decarboxylase 1	Rattus norvegicus	55-78
3948865-1	1986	Changes in both synthesis rate and degradation rate of ornithine decarboxylase (ODC) were pursued in primary cultures of adult rat hepatocytes during the process of ODC induction caused by asparagine and glucagon and also during the process of rapid ODC decay caused by putrescine.	Asparagine	189-199	ornithine decarboxylase 1	Rattus norvegicus	80-83
3948865-1	1986	Changes in both synthesis rate and degradation rate of ornithine decarboxylase (ODC) were pursued in primary cultures of adult rat hepatocytes during the process of ODC induction caused by asparagine and glucagon and also during the process of rapid ODC decay caused by putrescine.	Asparagine	189-199	ornithine decarboxylase 1	Rattus norvegicus	165-168
3948865-1	1986	Changes in both synthesis rate and degradation rate of ornithine decarboxylase (ODC) were pursued in primary cultures of adult rat hepatocytes during the process of ODC induction caused by asparagine and glucagon and also during the process of rapid ODC decay caused by putrescine.	Asparagine	189-199	ornithine decarboxylase 1	Rattus norvegicus	165-168
2870061-1	1986	gamma-Glutamyltranspeptidase purified from human kidneys contains 4-5 asparagine-linked sugar chains in each molecule.	Asparagine	70-80	inactive glutathione hydrolase 2	Homo sapiens	0-28
2432409-9	1986	The antiserum bound to prothymosin alpha and thymosin alpha 11, which lack the alpha-carboxylate group of Asn-28, with 0.9 and 0.2%, respectively, of the efficiency of thymosin alpha 1.	Asparagine	106-109	prothymosin alpha pseudogene 9	Homo sapiens	23-62
3332019-4	1986	The predicted primary protein product of the int-1 gene is 370 amino acids in length and cysteine-rich; immunoprecipitation with anti-peptide antibodies reveals multiple species of int-1 protein, due to asparagine-linked glycosylations and probable cleavage of a signal peptide.	Asparagine	203-213	Wnt family member 1	Homo sapiens	181-186
4084239-4	1985	Upon L-asparaginase treatment both cell lines lost most of their cellular asparagine but, whereas the resistant cells exhibited the ability to rebound to about 50% of initial values, the sensitive cells did not.	Asparagine	74-84	asparaginase like 1	Mus musculus	5-19
3877728-10	1985	The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn).	Asparagine	126-129	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-63
4066670-13	1985	One possibility which accounts for the presence of oligosaccharide C1 and D is that a bisecting N-acetylglucosamine (the beta-N-acetylglucosamine residue linked at the C-4 position of the beta-mannosyl residue of the trimannosyl core of the asparagine-linked sugar chains) is linked by a beta-mannosyl residue.	Asparagine	241-251	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	67-75
4093242-7	1985	Based upon mathematical calculations, beta-turns were predicted around three glycosylated Asn residues of PRG.	Asparagine	90-93	proline rich protein BstNI subfamily 3	Homo sapiens	106-109
4093242-8	1985	These collective data suggest that PRG is composed of a disordered polypeptide chain with at least three of the N-linked Asn residues participating in some type of beta-turn.	Asparagine	121-124	proline rich protein BstNI subfamily 3	Homo sapiens	35-38
4091848-1	1985	Evidence is presented that the hypoglycemic action of the human growth hormone fragment, Ile-Pro-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala (hGH 4-15) is due to the interaction of hGH 4-15 with plasma membrane resulting in a time- and temperature-dependent release of a cellular mediator which acts to increase insulin binding and hexose transport with consequent potentiation of insulin action.	Asparagine	121-124	growth hormone 1	Homo sapiens	64-78
4030774-8	1985	The enhancement of methylation by alkaline treatment is substantially reduced if calmodulin is first reacted with bis-(I,I-trifluoroacetoxy)iodobenzene, a reagent which converts the carboxamide group of asparagine and glutamine residues to the corresponding primary amines.	Asparagine	203-213	calmodulin	Bos taurus	81-91
4074713-0	1985	Structures of the sugar chains of rabbit immunoglobulin G: occurrence of asparagine-linked sugar chains in Fab fragment.	Asparagine	73-83	FA complementation group B	Homo sapiens	107-110
4074713-1	1985	The asparagine-linked sugar chains of rabbit immunoglobulin G (IgG) and its Fc and Fab fragments were quantitatively liberated from the polypeptide portions by hydrazinolysis followed by N-acetylation and NaB3H4 reduction.	Asparagine	4-14	FA complementation group B	Homo sapiens	83-86
4074713-3	1985	Rabbit IgG was shown to contain 2.3 mol of asparagine-linked sugar chains per molecule distributed in both the Fc and Fab fragments.	Asparagine	43-53	FA complementation group B	Homo sapiens	118-121
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Asparagine	187-190	epidermal growth factor	Mus musculus	135-158
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Asparagine	187-190	epidermal growth factor receptor	Mus musculus	160-165
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Asparagine	235-238	epidermal growth factor	Mus musculus	135-158
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Asparagine	235-238	epidermal growth factor receptor	Mus musculus	160-165
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	Asparagine	259-262	thyroglobulin	Homo sapiens	195-208
3928633-3	1985	Newly synthesized H-2Kk is transported rapidly such that all radiolabeled molecules reach the surface within 1 h. In contrast, the H-2Dk antigen is transported slowly with a half-time of 4-5 h. The rates of surface appearance for the two antigens closely resemble the rates at which their Asn-linked oligosaccharides mature from endoglucosaminidase H (endo H)-sensitive to endo H-resistant forms, a process that occurs in the Golgi apparatus.	Asparagine	289-292	histocompatibility 2, K1, K region	Mus musculus	18-23
24241228-6	1985	It was found that NAD-synthetase accepted both glutamine and asparagine for the amide transfer.	Asparagine	61-71	glutamine-dependent NAD(+) synthetase	Nicotiana tabacum	18-32
3930453-1	1985	Human chorionic gonadotropin (hCG) highly purified from the urine of patients with trophoblastic diseases (choriocarcinoma and hydatidiform mole) and from healthy pregnant women contains four asparagine-linked sugar chains in one molecule.	Asparagine	192-202	chorionic gonadotropin subunit beta 5	Homo sapiens	6-34
4030963-6	1985	Using this method we confirmed that the Asn residue in hPTH at position 76 could not be converted into the Asp residue under the conditions used to isolate and purify it from human organs.	Asparagine	40-43	parathyroid hormone	Homo sapiens	55-59
3970979-2	1985	The greatest percentages of inhibition of TPA-induced epidermal ornithine decarboxylase activity were as follows: cysteine, 98%; tryptophan, 74%; methionine, 64%; phenylalanine, 51%; glycine, 44%; asparagine, 43%; glutamic acid, 42%; leucine, 40%; and arginine, 39%.	Asparagine	197-207	ornithine decarboxylase 1	Homo sapiens	64-87
3934525-5	1985	From the results it was concluded that the basic beta 2m form has lysine and the acidic beta 2m form has asparagine as their respective C-terminal amino acids.	Asparagine	105-115	beta-2-microglobulin	Cavia porcellus	88-95
2859293-3	1985	Asparagine and the nonmetabolizable alpha-amino-isobutyric acid (AIB) were used as representatives of this class of inducing amino acids, and their intracellular concentrations were related to the levels of ODC induced.	Asparagine	0-10	ornithine decarboxylase 1	Homo sapiens	207-210
2859293-4	1985	A threshold intracellular concentration of asparagine or AIB has to be attained before ODC can be induced.	Asparagine	43-53	ornithine decarboxylase 1	Homo sapiens	87-90
2859293-5	1985	Further slight increases in intracellular concentrations of asparagine or AIB produce disproportionately large increases of ODC, resulting in a sigmoidal curve of ODC induction.	Asparagine	60-70	ornithine decarboxylase 1	Homo sapiens	124-127
2859293-5	1985	Further slight increases in intracellular concentrations of asparagine or AIB produce disproportionately large increases of ODC, resulting in a sigmoidal curve of ODC induction.	Asparagine	60-70	ornithine decarboxylase 1	Homo sapiens	163-166
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Asparagine	254-264	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
3971914-4	1985	Both forms are converted to mature PRL by digestion with endoglycosidase H and, thus, appear to contain only asparagine-linked, high mannose-type carbohydrate moieties.	Asparagine	109-119	prolactin	Bos taurus	35-38
2981070-7	1985	This study suggests that all the asn/gln residues which deamidate in order to make des-amido forms 1, 2, and 3 constitute part of the receptor-binding domains of both secreted and stored PRLs, while only a fraction of those same residues form portions of PRL"s antigenic sites.	Asparagine	33-36	prolactin	Mus musculus	187-190
2578035-7	1985	Since there is only one Asn-X-Ser(Thr) sequence in hPRL, the asparagine at position 31 is the likely point of N-linked glycosylation.	Asparagine	61-71	prolactin	Homo sapiens	51-55
3856097-3	1985	The I-Ak alpha-chain has two N-linked glycosylation sites at Asn-82 and Asn-122.	Asparagine	61-64	Fc gamma receptor and transporter	Homo sapiens	9-20
3856097-3	1985	The I-Ak alpha-chain has two N-linked glycosylation sites at Asn-82 and Asn-122.	Asparagine	72-75	Fc gamma receptor and transporter	Homo sapiens	9-20
3964822-3	1985	The highly conserved glycosylation site at amino acid position 86 was changed from asparagine to lysine to remove the carbohydrate moiety from the first external domain of the H-2 molecule, and the phenylalanine at position 116 was changed to tyrosine, replacing the Ld residue with the Kb type amino acid analogous to Kb mutants: bm5 and bm16 mutants derived from the Kb antigen have the Ld-type residue at this position.	Asparagine	83-93	histocompatibility-2, MHC	Mus musculus	176-179
3846593-4	1985	Of these fragments, the COOH-terminal fragment, which includes Asn-200 to the COOH-terminal end of the alpha-thrombin molecule, partially inhibited the complex formation between staphylocoagulase and human prothrombin.	Asparagine	63-66	coagulation factor II, thrombin	Homo sapiens	109-117
3846593-4	1985	Of these fragments, the COOH-terminal fragment, which includes Asn-200 to the COOH-terminal end of the alpha-thrombin molecule, partially inhibited the complex formation between staphylocoagulase and human prothrombin.	Asparagine	63-66	coagulation factor II, thrombin	Homo sapiens	206-217
3841691-2	1985	These studies indicated the presence of a new L-asparaginase amidohydrolase type enzyme in eel plasma which deamidates L-asparagine residue at the amino terminus of the angiotensin peptides, thereby implying that l-asparaginyl decapeptide (rather than l-aspartyl decapeptide) is the natural form of angiotensin inherent in eel plasma.	Asparagine	119-131	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-60
3880572-1	1985	The importance of asparagine-linked glycosylation in the cell surface expression of several class I molecules was examined.	Asparagine	18-28	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	92-99
3883606-2	1985	The deamidized preparation of serum albumin was obtained during its incubation under sterile conditions at 37 degrees C. The amount of amide groups in the process of protein incubation decreased by 19.4% mainly due to readily hydrolyzed asparagine groups.	Asparagine	237-247	albumin	Rattus norvegicus	36-43
6097248-2	1984	Partial nucleotide sequencing of the cloned DNA revealed the location of a 120-bp long intron between Lys-41 and Asn-42 of the ANF precursor.	Asparagine	113-116	natriuretic peptide A	Homo sapiens	127-130
6527384-2	1984	Oxygen equilibrium studies showed that stripped Hb Wayne Asn and Hb Wayne Asp possessed high oxygen affinity (P 1/2 = 0.60 and 0.23 mmHg at pH 7, respectively), were non-co-operative and have a markedly reduced Bohr effect (-delta log P 1/2/pH (7 to 8) = 0.34 and 0.10, respectively).	Asparagine	57-60	catenin delta 1	Homo sapiens	110-119
6527384-2	1984	Oxygen equilibrium studies showed that stripped Hb Wayne Asn and Hb Wayne Asp possessed high oxygen affinity (P 1/2 = 0.60 and 0.23 mmHg at pH 7, respectively), were non-co-operative and have a markedly reduced Bohr effect (-delta log P 1/2/pH (7 to 8) = 0.34 and 0.10, respectively).	Asparagine	57-60	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	235-243
6525362-4	1984	It was found that the carbohydrate component of this prolactin form is attached to asparagine at position 31; no differences were revealed between the amino acid composition of the major and glycosylated forms of the hormone.	Asparagine	83-93	prolactin	Homo sapiens	53-62
6088513-5	1984	Deamidation of asparagine 25 leads to the formation of an atypical isopeptide bond in which the resulting aspartyl residue is linked to the adjacent glycine 26 via its side-chain beta-carboxyl group rather than the usual alpha-carboxyl linkage (Graf, L., Bajusz, S., Patthy A., Barat, E., and Cseh, G. (1971) Acta Biochim.	Asparagine	15-25	Rho GTPase activating protein 26	Homo sapiens	245-249
6091745-3	1984	Phosvitin contains a core region of 99 amino acids, consisting of 80 serines, grouped in runs of maximally 14 residues interspersed by arginines, lysines, and asparagines.	Asparagine	159-170	Casein kinase II subunit beta	Gallus gallus	0-9
6236212-2	1984	Edman degradation of six different preparations revealed the amino-terminal sequence of thrombospondin (TSP) to be Asn-Arg-Ile-Pro-Glu-Ser-Gly-Gly-Asp-Asn-Ser-Val-Phe-.	Asparagine	115-118	thrombospondin 1	Homo sapiens	88-102
6389319-1	1984	The induction and decay of ornithine decarboxylase (ODC) by insulin and asparagine in cultures of H4-II-EC3 (H35) hepatoma cells was studied in a modified Waymouth medium in the presence of fetal bovine serum (FBS) and in serum-free media.	Asparagine	72-82	ornithine decarboxylase 1	Rattus norvegicus	27-50
6389319-1	1984	The induction and decay of ornithine decarboxylase (ODC) by insulin and asparagine in cultures of H4-II-EC3 (H35) hepatoma cells was studied in a modified Waymouth medium in the presence of fetal bovine serum (FBS) and in serum-free media.	Asparagine	72-82	ornithine decarboxylase 1	Rattus norvegicus	52-55
6389319-4	1984	Putrescine (the product formed from ornithine by ODC), at 10(-5) M, markedly inhibited the induction of ODC by insulin or FBS, but the inhibition was less when asparagine was present.	Asparagine	160-170	ornithine decarboxylase 1	Rattus norvegicus	49-52
6389319-4	1984	Putrescine (the product formed from ornithine by ODC), at 10(-5) M, markedly inhibited the induction of ODC by insulin or FBS, but the inhibition was less when asparagine was present.	Asparagine	160-170	ornithine decarboxylase 1	Rattus norvegicus	104-107
6236212-2	1984	Edman degradation of six different preparations revealed the amino-terminal sequence of thrombospondin (TSP) to be Asn-Arg-Ile-Pro-Glu-Ser-Gly-Gly-Asp-Asn-Ser-Val-Phe-.	Asparagine	115-118	thrombospondin 1	Homo sapiens	104-107
6203905-6	1984	CB2 contains two glucosamine-based carbohydrate groups attached to Asn-23 and Asn-38, and one internal disulfide bridge connecting Cys-16 with Cys-54.	Asparagine	67-70	cannabinoid receptor 2	Homo sapiens	0-3
6203905-6	1984	CB2 contains two glucosamine-based carbohydrate groups attached to Asn-23 and Asn-38, and one internal disulfide bridge connecting Cys-16 with Cys-54.	Asparagine	78-81	cannabinoid receptor 2	Homo sapiens	0-3
6235906-4	1984	The highest activity was obtained with the substrate Man alpha 1-3(R1 alpha 1-6)Man beta 1-R2 where R1 was Man alpha 1-3(Man alpha 1-6)Man- (Km = 0.20 mM) and R2 was -4GlcNAc beta 1-4GlcNAc-Asn.	Asparagine	190-193	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-90
6202883-2	1984	DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein.	Asparagine	132-142	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	29-43
6235906-4	1984	The highest activity was obtained with the substrate Man alpha 1-3(R1 alpha 1-6)Man beta 1-R2 where R1 was Man alpha 1-3(Man alpha 1-6)Man- (Km = 0.20 mM) and R2 was -4GlcNAc beta 1-4GlcNAc-Asn.	Asparagine	190-193	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	175-181
6235906-5	1984	Somewhat less effective were substrates in which R1 was Man- (Km = 0.4-0.6 mM) and R2 was either-4GlcNAc or -4GlcNAc beta 1-4(Fuc alpha 1-6)GlcNAc-Asn.	Asparagine	147-150	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
6608959-0	1984	A study of the role of the asparagine-linked sugar chains of human complement subcomponent C1q in its biological activities.	Asparagine	27-37	complement C1q A chain	Homo sapiens	91-94
6443592-6	1984	The first 19 amino acids are uncharged and presumably serve as the signal sequence for the insertion of PE2 into the membrane of the endoplasmic reticulum, but this sequence is unusual in that it is not immediately cleaved from PE2 and is glycosylated at the asparagine at position 14.	Asparagine	259-269	ETS2 repressor factor	Homo sapiens	104-107
6608959-1	1984	The sialic acid residues were removed from asparagine-linked sugar chains on the C-terminal non-collagenous globular regions of human C1q by sialidase digestion.	Asparagine	43-53	complement C1q A chain	Homo sapiens	134-137
6425277-3	1984	Purified rat liver Golgi galactosyltransferase was used with GlcNAc beta 1,2-Man alpha 1,6-(GlcNAc beta 1,2-Man alpha 1,3-)-Man beta 1,4-GlcNAc beta 1,4-(Fuc alpha 1,6-)-GlcNAc-Asn in order to determine the sequence of addition of Gal residues to the biantennary oligosaccharide.	Asparagine	177-180	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-76
6608959-4	1984	A mixture of entire asparagine-linked sugar chains consisting of neutral, monosialyl and disialyl oligosaccharides was isolated from the intact C1q molecule by hydrazinolysis.	Asparagine	20-30	complement C1q A chain	Homo sapiens	144-147
6425277-3	1984	Purified rat liver Golgi galactosyltransferase was used with GlcNAc beta 1,2-Man alpha 1,6-(GlcNAc beta 1,2-Man alpha 1,3-)-Man beta 1,4-GlcNAc beta 1,4-(Fuc alpha 1,6-)-GlcNAc-Asn in order to determine the sequence of addition of Gal residues to the biantennary oligosaccharide.	Asparagine	177-180	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-107
6704377-7	1984	However, chemotactic activity is only minimally reduced subsequent to hydrolysis by both neuraminidase and beta-galactosidase, indicating that receptor recognition and stimulated cell movement are mainly a function of structure of the cyanogen bromide derived fragment rather than of asparagine-linked carbohydrates.	Asparagine	284-294	neuraminidase 1	Homo sapiens	89-102
6425277-3	1984	Purified rat liver Golgi galactosyltransferase was used with GlcNAc beta 1,2-Man alpha 1,6-(GlcNAc beta 1,2-Man alpha 1,3-)-Man beta 1,4-GlcNAc beta 1,4-(Fuc alpha 1,6-)-GlcNAc-Asn in order to determine the sequence of addition of Gal residues to the biantennary oligosaccharide.	Asparagine	177-180	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	68-74
6425277-3	1984	Purified rat liver Golgi galactosyltransferase was used with GlcNAc beta 1,2-Man alpha 1,6-(GlcNAc beta 1,2-Man alpha 1,3-)-Man beta 1,4-GlcNAc beta 1,4-(Fuc alpha 1,6-)-GlcNAc-Asn in order to determine the sequence of addition of Gal residues to the biantennary oligosaccharide.	Asparagine	177-180	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	99-105
6706006-3	1984	Asparagine-linked glycopeptides were found to be mainly composed of the complex bi-antennary type as shown by affinity chromatography on concanavalin-A Sepharose; high-molecular-weight glycopeptides were represented by nonfucosylated lactosaminoglycans since they were metabolically labeled with [14C]glucosamine but not with [3H]fucose, did not bind to DEAE-cellulose, and were susceptible to endo-beta-galactosidase.	Asparagine	0-10	galactosidase, beta 1	Mus musculus	399-417
6717443-5	1984	Comparison of this sequence with those of other H-2 class I molecules revealed that: (1) Lys-19, Val-55, Glu-56, Asn-63 and Ile-73 are unique to the H-2Kk molecule; and (2) H-2Kk shares 79-83% homology in this region with other mouse class I molecules.	Asparagine	113-116	histocompatibility 2, K1, K region	Mus musculus	149-154
6712957-1	1984	The reversible unfolding of rat alpha-lactalbumin, which, in contrast to other alpha-lactalbumins, has a 17-amino-acid extension at the carboxyl terminus and a carbohydrate unit at Asn-45, was studied by circular dichroism between 193 and 310 nm as a function of pH, heat and guanidine hydrochloride ( GdnHCl ).	Asparagine	181-184	lactalbumin, alpha	Rattus norvegicus	32-49
6373642-2	1984	Human [10-asparagine-B] insulin ([ Asn10 -B] insulin), an analogue which differs from the parent molecule in that the histidine residue at position 10 of the B chain (B10) is replaced by asparagine, has been synthesized and isolated in purified form.	Asparagine	9-20	insulin	Homo sapiens	24-31
6373642-2	1984	Human [10-asparagine-B] insulin ([ Asn10 -B] insulin), an analogue which differs from the parent molecule in that the histidine residue at position 10 of the B chain (B10) is replaced by asparagine, has been synthesized and isolated in purified form.	Asparagine	10-20	insulin	Homo sapiens	24-31
6421816-6	1984	In the apo-A-I of family A, the abnormality was shown to occur in the smallest cyanogen bromide fragment, CB-2 (residues 87-112), and amino acid sequencing revealed asparagine instead of the usual aspartic acid at residue 103.	Asparagine	165-175	apolipoprotein A1	Homo sapiens	7-14
6697962-11	1984	The heterogeneity of secreted angiotensinogen can be fully accounted for by differences in N-glycosylation of asparagine residues of the molecule.	Asparagine	110-120	angiotensinogen	Rattus norvegicus	30-45
16663468-3	1984	The present study was designed to explore the effects of two ammonium assimilation inhibitors on the metabolism of (14)CO(2) to [(14)C]asparagine and to demonstrate the existence in nodules of the enzyme asparagine synthetase.	Asparagine	135-145	asparagine synthetase	Glycine max	204-225
6367658-5	1984	Such changes may in turn account, in part at least, for the capacity of L-asparagine to augment insulin release induced by certain nutrient secretagogues.	Asparagine	72-84	insulin	Homo sapiens	96-103
6696440-4	1984	Affinity chromatography on lentil lectin-agarose demonstrated that 84% of the dopamine beta-hydroxylase biantennary oligosaccharides are substituted by fucose on the core N-acetylglucosamine which is linked to asparagine.	Asparagine	210-220	dopamine beta-hydroxylase	Bos taurus	78-103
6538886-5	1984	The antiserum seemed to recognize the carboxy-terminal seven amino acid residues, Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH, of the FTS molecule.	Asparagine	106-112	AKT interacting protein	Mus musculus	121-124
6395724-7	1984	This sequence is identical with that of residues 491-495 of the sequence for human serum transferrin (MacGillivray et al., 1982) except that in the bovine transferrin, Asp is replaced by Asn, enabling carbohydrate attachment.	Asparagine	187-190	serotransferrin	Bos taurus	89-100
6395724-7	1984	This sequence is identical with that of residues 491-495 of the sequence for human serum transferrin (MacGillivray et al., 1982) except that in the bovine transferrin, Asp is replaced by Asn, enabling carbohydrate attachment.	Asparagine	187-190	serotransferrin	Bos taurus	155-166
6332114-4	1984	EGF b differed from EGF a in that it lacked the N-terminal asparagine.	Asparagine	59-69	epidermal growth factor	Mus musculus	0-3
6644098-2	1983	Incubation of isolated epidermal cells with mM concentrations of glycine, asparagine, glutamic acid, canavanine, arginine, and/or lysine inhibited dramatically the induction of ornithine decarboxylase activity by the tumor promoter.	Asparagine	74-84	ornithine decarboxylase, structural 1	Mus musculus	177-200
6480363-0	1984	Hemoglobin Presbyterian [beta 108(G10) Asn----Lys] found in Japan.	Asparagine	39-46	BUD31 homolog	Homo sapiens	30-37
6864547-0	1983	Inhibition of asparagine-linked glycosylation of pro-opiomelanocortin in mouse pituitary cells by DL-threo-beta-fluoroasparagine.	Asparagine	14-24	pro-opiomelanocortin-alpha	Mus musculus	49-69
6352261-4	1983	The A chain contains a total of 22 amino acids; only the insulin from coypu (a member of the Rodentia suborder, Hystricomorpha), has previously been reported to contain an extension past the A21 asparagine.	Asparagine	195-205	insulin	Bos taurus	57-64
6885799-1	1983	Aspartylglucosaminidase (EC 3.5.1.26), the lysosomal enzyme which hydrolyzes the N-acetylglucosamine-asparagine linkages in glycoproteins, was purified from human liver to homogeneity.	Asparagine	101-111	aspartylglucosaminidase	Homo sapiens	0-23
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Asparagine	94-98	calmodulin	Bos taurus	216-226
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Asparagine	94-97	calmodulin	Bos taurus	216-226
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Asparagine	98-101	calmodulin	Bos taurus	216-226
6870264-1	1983	Adrenal proenkephalin contains the sequence -Asn-Ser-Ser- that is a typical site for the attachment of asparagine-linked carbohydrate.	Asparagine	45-48	proenkephalin	Bos taurus	8-21
6309340-7	1983	Two of four putative isozymes of 17 beta-hydroxysteroid dehydrogenase had serine as the amino terminus while the other two had aspartic acid or asparagine.	Asparagine	144-154	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	33-69
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Asparagine	172-175	Mf(Alpha)2p	Saccharomyces cerevisiae S288C	0-10
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Asparagine	172-175	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	138-148
6875826-1	1983	The antitumor effect of immobilized L-asparaginase was tested against lymphoid leukemia in mice with concomitant scanning of the L-asparagine level in serum.	Asparagine	129-141	asparaginase like 1	Mus musculus	36-50
6880770-4	1983	However, further modifications by adding high concentrations of asparagine and leucine increased AHH activity to 62% of initial values, but did not further enhance the total content of cytochrome P-450 or the EM N-demethylase activity.	Asparagine	64-74	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	97-100
6853476-1	1983	Bovine blood coagulation factor IX (Christmas factor) contains four asparagine-linked sugar chains in one molecule.	Asparagine	68-78	coagulation factor IX	Homo sapiens	36-52
6298732-0	1983	Isolation and nucleotide sequence of a plant tRNA gene: petunia asparagine tRNA.	Asparagine	64-74	mitochondrially encoded tRNA glycine	Homo sapiens	45-49
6600628-2	1983	Guinea pig and mouse C1q, subcomponents of the first component of complement, contained six asparagine-linked sugar chains on the C-terminal non-collagenous globular regions of each molecule.	Asparagine	92-102	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	21-24
6341118-1	1983	A synthetic amino-terminal fragment of human growth hormone (hGH) containing the sequence H2N-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala-COOH (hGH 6-13) was shown to increase [125I]iodoinsulin binding to rat hepatic receptors in vivo.	Asparagine	118-121	growth hormone 1	Homo sapiens	45-59
6826541-8	1983	Thus, the 2 oligosaccharide-linked asparagines in cathepsin D correspond to residues 67 and 183 in pepsin and other homologous aspartyl proteases.	Asparagine	35-46	cathepsin D	Homo sapiens	50-61
6298732-0	1983	Isolation and nucleotide sequence of a plant tRNA gene: petunia asparagine tRNA.	Asparagine	64-74	mitochondrially encoded tRNA glycine	Homo sapiens	75-79
6298732-1	1983	A 14.3 kb petunia genomic DNA fragment was isolated and found to contain a single tRNA gene coding for asparagine tRNA.	Asparagine	103-113	mitochondrially encoded tRNA glycine	Homo sapiens	82-86
6298732-1	1983	A 14.3 kb petunia genomic DNA fragment was isolated and found to contain a single tRNA gene coding for asparagine tRNA.	Asparagine	103-113	mitochondrially encoded tRNA glycine	Homo sapiens	114-118
6298732-2	1983	The nucleotide sequence of the asparagine tRNA gene and its flanking regions has been determined.	Asparagine	31-41	mitochondrially encoded tRNA glycine	Homo sapiens	42-46
6298732-3	1983	This gene does not contain intervening sequences nor the 3"-end CCA sequence of the mature tRNA and presents a similar overall sequence homology (70%) to both E. coli and mammalian asparagine tRNA.	Asparagine	181-191	mitochondrially encoded tRNA glycine	Homo sapiens	91-95
6298732-3	1983	This gene does not contain intervening sequences nor the 3"-end CCA sequence of the mature tRNA and presents a similar overall sequence homology (70%) to both E. coli and mammalian asparagine tRNA.	Asparagine	181-191	mitochondrially encoded tRNA glycine	Homo sapiens	192-196
6132953-3	1983	DNA from the replicative form of clone M13 OriC, containing the bacterial gene for Asn Syn, was shown to be capable of causing transformation of Jensen rat Asn Syn- cells to cells capable of growth in Asn-free medium; no prior modification of the bacterial gene was required.	Asparagine	83-86	synemin	Homo sapiens	87-90
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Asparagine	235-238	neurotensin	Bos taurus	41-52
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Asparagine	235-238	neurotensin	Bos taurus	54-56
6132953-3	1983	DNA from the replicative form of clone M13 OriC, containing the bacterial gene for Asn Syn, was shown to be capable of causing transformation of Jensen rat Asn Syn- cells to cells capable of growth in Asn-free medium; no prior modification of the bacterial gene was required.	Asparagine	83-86	synemin	Homo sapiens	160-163
6132953-3	1983	DNA from the replicative form of clone M13 OriC, containing the bacterial gene for Asn Syn, was shown to be capable of causing transformation of Jensen rat Asn Syn- cells to cells capable of growth in Asn-free medium; no prior modification of the bacterial gene was required.	Asparagine	156-159	synemin	Homo sapiens	87-90
6132953-3	1983	DNA from the replicative form of clone M13 OriC, containing the bacterial gene for Asn Syn, was shown to be capable of causing transformation of Jensen rat Asn Syn- cells to cells capable of growth in Asn-free medium; no prior modification of the bacterial gene was required.	Asparagine	156-159	synemin	Homo sapiens	160-163
6129975-9	1982	Both OX 2 antigens contained carbohydrate residues typical of structures N-linked to asparagine but lacked galactosamine, indicating the absence of O-linked structures.	Asparagine	85-95	OX-2 membrane glycoprotein	Oryctolagus cuniculus	5-9
6299885-2	1982	The derived amino acid sequence of the cytochrome b protein from the light strand indicated that the C-terminal amino acid is asparagine and the ochre termination codon is encoded in the DNA, in contrast to the the lack of termination codon in the reading frame of human [Anderson et al., Nature 290 (1981) 457] or mouse [Bibb et al., Cell 26 (1981) 167] mitochondrial DNA.	Asparagine	126-136	mitochondrially encoded cytochrome b	Homo sapiens	39-51
6819087-4	1982	These results suggest that ZP2 is synthesized as an 81 kd polypeptide chain that is first "core"-glycosylated at asparagine residues with high-mannose-type oligosaccharides, giving rise to a 91 kd intermediate (Endo-H-sensitive), and then processed to complex-type oligosaccharides prior to secretion as mature, 120 kd ZP2 (Endo H-insensitive).	Asparagine	113-123	zona pellucida glycoprotein 2	Homo sapiens	27-30
6217905-0	1982	[Hemoglobin Beijing [alpha 16 (A14) Lys leads to Asn]: a new fast moving hemoglobin variant].	Asparagine	49-52	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	31-34
6749836-3	1982	In the presence of tunicamycin, an inhibitor of the synthesis of protein-asparagine linked carbohydrate moieties, two smaller molecular forms each of precursor and mature proteinase A were synthesized, indicating that proteinase A contains N-linked carbohydrate which is apparently not required for processing.	Asparagine	73-83	proteinase A	Saccharomyces cerevisiae S288C	218-230
6816218-3	1982	The N-terminal amino acid sequence of rabbit serum transferrin is: Val-Thr-Glu-Lys-Thr-Val-Asn-Trp-?-Ala-Val-Ser.	Asparagine	91-94	transferrin	Homo sapiens	51-62
6763931-6	1982	Continuous intravenous infusion of glutamine (3 mmol/h per kg estimated fetal weight) or glutamine and asparagine each at this rate for 2 h into chronically cannulated fetal sheep in utero significantly increased plasma glucagon (P less than 0.05) and insulin (P less than 0.01) concentrations, although the effect on glucagon was not great.	Asparagine	103-113	LOC105613195	Ovis aries	252-259
7115771-9	1982	Ornithine decarboxylase activity can be elicited by a variety of asparagine and other amino acid analogs, including alpha-aminoisobutyric acid, that cannot participate in protein synthesis.	Asparagine	65-75	ornithine decarboxylase 1	Homo sapiens	0-23
7115771-10	1982	Of the eleven asparagine analogs tested, alpha-N-CH3-DL-asparagine is the most potent in eliciting ornithine decarboxylase activity and is equivalent to asparagine in this regard.	Asparagine	14-24	ornithine decarboxylase 1	Homo sapiens	99-122
7115771-10	1982	Of the eleven asparagine analogs tested, alpha-N-CH3-DL-asparagine is the most potent in eliciting ornithine decarboxylase activity and is equivalent to asparagine in this regard.	Asparagine	56-66	ornithine decarboxylase 1	Homo sapiens	99-122
7115771-11	1982	Inclusion of polar groups into the asparagine molecule results in the loss of its ability to elicit ornithine decarboxylase activity.	Asparagine	35-45	ornithine decarboxylase 1	Homo sapiens	100-123
6981411-5	1982	The asparagine residue at position A-124 has been identified as the major site of asparagine-linked carbohydrate in subcomponent C1q.	Asparagine	4-14	complement C1q A chain	Homo sapiens	129-132
6896642-1	1982	An L-asparaginase (EC 3.5.1.1) specific for L-asparagine has been purified from a marine Chlamydomonas species, the first such enzyme to be purified from a microalga.	Asparagine	44-56	asparaginase and isoaspartyl peptidase 1	Homo sapiens	3-17
7118871-1	1982	Human fibrinogen contains four asparagine-linked sugar chains in one molecule.	Asparagine	31-41	fibrinogen beta chain	Homo sapiens	6-16
6980116-1	1982	Human alpha 1-protease inhibitor contains four asparagine-linked carbohydrate chains per molecule.	Asparagine	47-57	serpin family A member 1	Homo sapiens	6-32
16662109-3	1981	Biosynthetic glutamine synthetase activity was 1.5 to 1.8 times greater in nitrogen-limited cells than cells grown at high levels of the three nitrogen sources.Conversely, glutamate dehydrogenase (both NADH- and NADPH-dependent activities) was greatest in cells grown at high levels of asparagine or ammonium, while nitrate-grown cells possessed little activity at all concentrations employed.	Asparagine	286-296	glutamate-ammonia ligase	Homo sapiens	13-33
7053388-10	1982	These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine.	Asparagine	197-207	a1-a	Xenopus laevis	73-85
7309709-1	1981	Human prothrombin contains three asparagine-linked sugar chains in one molecule.	Asparagine	33-43	coagulation factor II, thrombin	Homo sapiens	6-17
6895481-11	1981	The minimal plasma level of L-asparaginase necessary to deplete CSF asparagine in both species was 0.1 IU/ml.	Asparagine	68-78	asparaginase and isoaspartyl peptidase 1	Homo sapiens	28-42
7028740-1	1981	The major desamido form of human growth hormone (hGH) results from deamidation of asparagine 152.	Asparagine	82-92	growth hormone 1	Homo sapiens	33-47
7309709-5	1981	By the combination of sequential exoglycosidase digestion and methylation analysis, the structures of the asparagine-linked sugar chains of human prothrombin were confirmed to be as follows: (sequence in text).	Asparagine	106-116	coagulation factor II, thrombin	Homo sapiens	146-157
7272338-1	1981	The elucidation of the structures of two carbohydrate units, N-glycosidically linked to an asparagine residue of bovine lactotransferrin, is described.	Asparagine	91-101	lactotransferrin	Bos taurus	120-136
6167628-2	1981	The EAE-inducing determinant (synthetic peptide S6) H-Ala-Gln-Gly-His-Arg-Pro-Gln-Asp-Glu-Asn-OH (residues 75 to 84) of the bovine MBP induced clinical and histologic signs of EAE when it was administered at doses of 0.5 micrograms or higher.	Asparagine	90-96	myelin basic protein	Bos taurus	131-134
6947966-4	1981	To avoid the L-asparagine rebound we have utilized, by extracorporeal route, L-glutaminase together with L-asparaginase, in order to reduce L-asparagine and L-glutamine levels.	Asparagine	140-152	asparaginase and isoaspartyl peptidase 1	Homo sapiens	105-119
7263622-6	1981	Here we present data showing that the asparagine-linked carbohydrate moiety of soybean agglutinin is homogeneous and possesses the following structure: (formula, see text) This conclusion is based on high resolution 1H NMR spectroscopy at 500 MHz of the isolated glycopeptide, and at 360 MHz of the oligosaccharide Man9GlcNAc obtained after digestion of the crude soybean agglutinin glycopeptide by endo-beta-N-acetylglucosaminidase H. The revised structure is identical in all respects with that of the high mannose N-glycosidic units of porcine thyroglobulin, of bovine lactotransferrin, and of the glycoprotein from Chinese hamster ovary cell membranes.	Asparagine	38-48	mannosidase alpha class 1A member 1	Homo sapiens	315-319
7263622-6	1981	Here we present data showing that the asparagine-linked carbohydrate moiety of soybean agglutinin is homogeneous and possesses the following structure: (formula, see text) This conclusion is based on high resolution 1H NMR spectroscopy at 500 MHz of the isolated glycopeptide, and at 360 MHz of the oligosaccharide Man9GlcNAc obtained after digestion of the crude soybean agglutinin glycopeptide by endo-beta-N-acetylglucosaminidase H. The revised structure is identical in all respects with that of the high mannose N-glycosidic units of porcine thyroglobulin, of bovine lactotransferrin, and of the glycoprotein from Chinese hamster ovary cell membranes.	Asparagine	38-48	lactotransferrin	Bos taurus	572-588
7018901-2	1981	The enzyme transferring the oligosaccharide from DolPP-(GlcNAc)2(Glc)3 to asparagine residues of glycoproteins has been solubilized from yeast membranes by extraction with detergents.	Asparagine	74-84	1,4-alpha-glucan branching enzyme	Saccharomyces cerevisiae S288C	49-70
7259746-0	1981	Substrate specificity of Diplococcal beta-N-acetylhexosaminidase, a useful enzyme for the structural studies of complex type asparagine-linked sugar chains.	Asparagine	125-135	O-GlcNAcase	Homo sapiens	37-64
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	Asparagine	334-337	galanin and GMAP prepropeptide	Homo sapiens	61-115
7251680-5	1981	These phenomena are unaffected by the presence of cycloheximide and are comparable to the requirement of L-asparagine for the maintenance of ODC activity.	Asparagine	105-117	ornithine decarboxylase 1	Homo sapiens	141-144
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	Asparagine	334-337	adrenoceptor alpha 1D	Homo sapiens	131-138
7451505-0	1981	Structural studies of asparagine-linked sugar chains of human ceruloplasmin.	Asparagine	22-32	ceruloplasmin	Homo sapiens	62-75
6940191-9	1981	When the oligosaccharide unit of human des-Arg(74)-C5a was removed by glycosidases, leaving a single glucosamine residue attached to the side chain of asparagine-64, activity was enhanced.	Asparagine	151-161	complement C5a receptor 1	Homo sapiens	51-54
7014485-2	1981	The human [12-Asparagine-B] insulin [Asn12-B] insulin) which differs from the parent molecule in that the valine residue at position B12 is substituted by an asparagine residue, has been synthesized by the procedures developed in this laboratory.	Asparagine	158-168	insulin	Homo sapiens	46-53
7014485-2	1981	The human [12-Asparagine-B] insulin [Asn12-B] insulin) which differs from the parent molecule in that the valine residue at position B12 is substituted by an asparagine residue, has been synthesized by the procedures developed in this laboratory.	Asparagine	13-24	insulin	Homo sapiens	28-35
7014485-2	1981	The human [12-Asparagine-B] insulin [Asn12-B] insulin) which differs from the parent molecule in that the valine residue at position B12 is substituted by an asparagine residue, has been synthesized by the procedures developed in this laboratory.	Asparagine	13-24	insulin	Homo sapiens	46-53
7014485-2	1981	The human [12-Asparagine-B] insulin [Asn12-B] insulin) which differs from the parent molecule in that the valine residue at position B12 is substituted by an asparagine residue, has been synthesized by the procedures developed in this laboratory.	Asparagine	158-168	insulin	Homo sapiens	28-35
7216819-0	1981	Hemoglobin G Copenhagen beta 47 (CD6) Asp leads to Asn in a Sicilian family.	Asparagine	51-54	CD6 molecule	Homo sapiens	33-36
7305921-3	1981	The positions of specific galactose residues and asparagine-linked carbohydrate chains containing specific mannose residues in epiglycanin, a glycoprotein of extended conformation from the surface of TA3 mouse mammary tumour cells, were observed in complexes with Ricinus communis toxin and concanavalin A respectively.	Asparagine	49-59	mucin 21	Mus musculus	127-138
7005335-2	1981	HLA-A and -B antigens are membrane glycoproteins that consist of a two chain complex, the heavy chain being glycosylated at Asn 86, whereas the light chain, identical to beta 2-microglobulin, is not glycosylated.	Asparagine	124-127	major histocompatibility complex, class I, A	Homo sapiens	0-12
7319829-0	1981	Hb Ube-2 (alpha 68[e-17]Asn replaced by Asp): the second instance in Japan.	Asparagine	24-27	ubiquitin like modifier activating enzyme 7	Homo sapiens	3-8
7228490-5	1981	The structures of the four human fragments are identical except for the presence of Asn at residue 4 in PRP-1 and -3 instead of Asp found in PRP-2 and -4.	Asparagine	84-87	pre-mRNA processing factor 3	Homo sapiens	104-116
7462199-1	1980	The asparagine-linked sugar chains of cold-insoluble globulin isolated from human plasma were released as oligosaccharides from the polypeptide moiety by hydrazinolysis.	Asparagine	4-14	fibronectin 1	Homo sapiens	38-61
6896751-1	1981	l-Asparaginase is used as a therapeutic enzyme to selectively destroy asparagine-dependent cancer cells.	Asparagine	70-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
7430095-0	1980	Structures of the asparagine-linked sugar chains of glycophorin A.	Asparagine	18-28	glycophorin A (MNS blood group)	Homo sapiens	52-65
6162548-0	1980	Structure of the asparagine-linked sugar chains of alpha-fetoprotein purified from human ascites fluid.	Asparagine	17-27	alpha fetoprotein	Homo sapiens	51-68
6162548-1	1980	alpha-Fetoprotein purified from human serum was found to contain an asparagine-linked sugar chain in one molecule.	Asparagine	68-78	alpha fetoprotein	Homo sapiens	0-17
7430095-1	1980	Glycophorin A isolated from human erythrocytes contains one asparagine-linked sugar chain in one molecule.	Asparagine	60-70	glycophorin A (MNS blood group)	Homo sapiens	0-13
7463002-5	1980	The single glycosylated asparagine in HA2 also occurs in CN-I; the carbohydrates moiety is complex.	Asparagine	24-34	keratin 32	Homo sapiens	38-41
7463002-5	1980	The single glycosylated asparagine in HA2 also occurs in CN-I; the carbohydrates moiety is complex.	Asparagine	24-34	5'-nucleotidase, cytosolic IA	Homo sapiens	57-61
6155159-1	1980	In each of two families from Sardinia, Italy, we have found segregation for two alpha-chain hemoglobin variants, which we have identified as G Philadelphia [alpha 68 (E17) Asn leads to Lys] and J Sardinia [alpha 50 (CE8) His leads to Asp], respectively.	Asparagine	172-175	Fc gamma receptor and transporter	Homo sapiens	80-91
6160579-3	1980	The NH2 terminus was determined to be NH2-Met1-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-Gln-X-Gln-Lys.	Asparagine	55-58	granzyme M	Homo sapiens	42-46
6249374-1	1980	Any one of five amino acis (alanine, asparagine, glutamine, glycine, and serine) is an essential requirement for the induction of ornithine decarboxylase (EC 4.1.1.17) in cultured chinese hamster ovary (CHO) cells maintained with a salts/glucose, medium.	Asparagine	37-47	ornithine decarboxylase 1	Homo sapiens	130-153
7005396-9	1980	In addition, 10(-2) M-L-asparagine stimulated ornithine decarboxylase activity in serum-free medium.	Asparagine	22-34	ornithine decarboxylase	Gallus gallus	46-69
6998976-16	1980	In addition, cathepsin D-II hydrolyzed the Leu-Val and Tyr-Thr bonds at pH 3.0 and the Val-Asn bond at pH 5.0.	Asparagine	91-94	cathepsin D	Macaca mulatta	13-24
6244857-6	1980	Space-filling models revealed the possibility of a hydrogen bond between the oxygen of amide of residue-70 asparagine and the epsilon-amino nitrogen of residue-72 lysine in unmethylated horse heart cytochrome C.	Asparagine	107-117	cytochrome c, somatic	Equus caballus	198-210
6772165-7	1980	The kinetics of ornithine decarboxylase "induction" and the half-life of the enzyme differed in cells incubated with buffered asparagine solutions and serum-containing media.	Asparagine	126-136	ornithine decarboxylase 1	Rattus norvegicus	16-39
7407676-4	1980	The PA 1 cells contained also oligomannosyl type glycans, presumably linked to asparagine (fraction C glycopeptides).	Asparagine	79-89	PAXIP1 associated glutamate rich protein 1	Homo sapiens	4-8
7370278-5	1980	Thrombin and Factor Xa may possess a hydrophobic region near the P2 binding site which is unfavourable for either asparagine or D-alanine but which readily accommodates glycine, L-alanine or L-phenylalanine.	Asparagine	114-124	coagulation factor II, thrombin	Bos taurus	0-8
7354024-0	1980	The structure of the asparagine-linked carbohydrate unit of rat alpha-lactalbumin.	Asparagine	21-31	lactalbumin, alpha	Rattus norvegicus	64-81
512928-9	1979	injection of 1000 I.U./kg into rats, the microparticles containing L-asparaginase lowered the plasma L-asparagine level for a substantially longer period of time than L-asparaginase in free solution.	Asparagine	101-113	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	67-81
118968-13	1979	Human, porcine, and rabbit antithrombin III have a histidine residue at the amino-terminus, while rat antithrombin III contains an amino-terminal asparagine residue.	Asparagine	146-156	serpin family C member 1	Homo sapiens	102-118
468841-2	1979	Cold-insoluble globulin isolated from bovine plasma contains six asparagine-linked sugar chains in 1 molecule (a dimeric form).	Asparagine	65-75	fibronectin 1	Homo sapiens	0-23
381308-8	1979	Both proteinase B inhibitors have threonine as the NH2-terminal residue and -Val-His-Thr-Asn-COO- as the COOH-terminal sequence.	Asparagine	89-92	proteinase B	Saccharomyces cerevisiae S288C	5-17
313838-2	1979	The responsiveness of human leukemic cell cultures to L-asparaginase indicates that those of T cell origin are much more sensitive to the action of this L-asparagine-depleting enzyme than those of B cell origin.	Asparagine	153-165	asparaginase and isoaspartyl peptidase 1	Homo sapiens	54-68
481679-6	1979	The stabilizing effect is most pronounced for GABA, although some amino acids such as asparagine, glutamine, and lysine as well as some GABA analogues and homologues also tend to increase ODC but to a significantly lesser extent than GABA itself.	Asparagine	86-96	ornithine decarboxylase 1	Rattus norvegicus	188-191
438217-3	1979	One of the prominent features common to all these glycopeptides was that they all contain 1 fucosyl residue at either C-3 or C-6 position of the N-acetylglucosamine which is linked to asparagine.	Asparagine	184-194	complement C3	Homo sapiens	118-121
438217-3	1979	One of the prominent features common to all these glycopeptides was that they all contain 1 fucosyl residue at either C-3 or C-6 position of the N-acetylglucosamine which is linked to asparagine.	Asparagine	184-194	complement C6	Homo sapiens	125-128
438217-4	1979	Possibly, accumulation of glycopeptides in fucosidosis urine is caused by the inability of human endo-beta-N-acetylglucosaminidase to cleave the asparagine-linked sugar chains, which have a fucose at the innermost N-acetylglucosamine residue.	Asparagine	145-155	O-GlcNAcase	Homo sapiens	102-130
447724-4	1979	The unusual features of the sugar chains of rhodopsin molecule seem to support the proposed processing pathway for the biosynthesis of asparagine-linked sugar chains of glycoproteins.	Asparagine	135-145	rhodopsin	Homo sapiens	44-53
447725-2	1979	Bovine prothrombin contains three asparagine-linked sugar chains in 1 molecule.	Asparagine	34-44	coagulation factor II, thrombin	Homo sapiens	7-18
380992-11	1979	The glycan moiety of lipase is bound to Asn-166.	Asparagine	40-43	lipase	Staphylococcus aureus	21-27
571739-2	1979	Phosphoenolpyruvate carboxylase (orthophosphate:oxaloacetate carboxylase (phosphorylating), EC 4.1.1.31) from plant cells of soybean nodules was studied to assess its role in providing carbon skeletons for aspartate and asparagine synthesis.	Asparagine	220-230	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	0-31
458811-2	1979	The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods.	Asparagine	84-87	nocturnin	Homo sapiens	49-52
457426-0	1979	Hb J Lome beta 59 (E3) Lys is replaced by Asn associated with HPFH in a Togolese family.	Asparagine	42-45	HBFQTL2	Homo sapiens	62-66
286306-1	1979	Placental RNA has previously been shown to direct the synthesis of an asparagine-linked mannose-rich glycosylated form of the alpha subunit of human chorionic gonadotropin (hCG-alpha) in lysates derived from mouse ascites tumor cells.	Asparagine	70-80	chromogranin A	Homo sapiens	173-182
701260-0	1978	The asparagine-linked sugar chains of subcomponent C1q of the first component of human complement.	Asparagine	4-14	complement C1q A chain	Homo sapiens	51-54
422323-1	1979	An analog of sheep insulin which differs from the parent molecule in that the C-terminal amino acid residue of the A chain, asparagine, is replaced by arginine, has been synthesized and isolated in highly purified form.	Asparagine	124-134	LOC105613195	Ovis aries	19-26
422323-6	1979	It has been suggested that in the insulin molecule the A21 asparagine participates in salt bridge- and hydrogen bond-forming interactions which are critical in the biological activity of the hormone.	Asparagine	59-69	LOC105613195	Ovis aries	34-41
690134-11	1978	The carbohydrate portion of C5a exists as a single complex oligosaccharide unit attached to an asparagine at position 64.	Asparagine	95-105	complement C5a receptor 1	Homo sapiens	28-31
99447-10	1978	We propose that TBG contains four oligosaccharide chains as calculated from the molecular weights of the glycopeptides and from compositional data assuming 1 asparagine residue/glycopeptide.	Asparagine	158-168	serpin family A member 7	Homo sapiens	16-19
701260-1	1978	Human C1q, a subcomponent of the first component of complement, contains six asparagine-linked sugar chains in 1 molecule.	Asparagine	77-87	complement C1q A chain	Homo sapiens	6-9
348677-1	1978	L-Asparagine auxotrophy in Saccharomyces cerevisiae is the result of mutation in each of two unlinked cistrons, ASN1 and ASN2.	Asparagine	0-12	asparagine synthase (glutamine-hydrolyzing) 1	Saccharomyces cerevisiae S288C	112-116
309725-4	1978	The asparagine buffered sheet gel now allows the differentiation of the genotypes AMY2B/AMY2B,AMY2B/AMY2A, and AMY2B/AMY2C, thus classifying these three alleles as codominants.	Asparagine	4-14	amylase alpha 2B	Homo sapiens	82-87
309725-4	1978	The asparagine buffered sheet gel now allows the differentiation of the genotypes AMY2B/AMY2B,AMY2B/AMY2A, and AMY2B/AMY2C, thus classifying these three alleles as codominants.	Asparagine	4-14	amylase alpha 2B	Homo sapiens	88-93
309725-4	1978	The asparagine buffered sheet gel now allows the differentiation of the genotypes AMY2B/AMY2B,AMY2B/AMY2A, and AMY2B/AMY2C, thus classifying these three alleles as codominants.	Asparagine	4-14	amylase alpha 2B	Homo sapiens	88-93
309725-4	1978	The asparagine buffered sheet gel now allows the differentiation of the genotypes AMY2B/AMY2B,AMY2B/AMY2A, and AMY2B/AMY2C, thus classifying these three alleles as codominants.	Asparagine	4-14	amylase alpha 2A	Homo sapiens	100-105
309725-4	1978	The asparagine buffered sheet gel now allows the differentiation of the genotypes AMY2B/AMY2B,AMY2B/AMY2A, and AMY2B/AMY2C, thus classifying these three alleles as codominants.	Asparagine	4-14	amylase alpha 2B	Homo sapiens	88-93
26414-0	1978	Properties of hemoglobin G. Ferrara (beta57(E1) Asn replaced by Lys).	Asparagine	48-51	small nucleolar RNA, H/ACA box 73A	Homo sapiens	37-46
632300-8	1978	Of the 19 residues known to be invariant in all insulins so far sequenced, only glutamine A5 and asparagine A21 are replaced in IGF-I by glutamic acid and alanine, respectively.	Asparagine	97-107	insulin like growth factor 1	Homo sapiens	128-133
279902-4	1978	In this way the presence of secretin, cholecystokinin, and the vasoactive intestinal peptide in concentrates of porcine intestinal extracts were demonstrated by their COOH-terminal amide fragments: valine (or leucylvaline) amide, phenylalanine amide, and asparagine (or leucylasparagine) amide, respectively.	Asparagine	255-265	secretin	Homo sapiens	28-36
348677-1	1978	L-Asparagine auxotrophy in Saccharomyces cerevisiae is the result of mutation in each of two unlinked cistrons, ASN1 and ASN2.	Asparagine	0-12	asparagine synthase (glutamine-hydrolyzing) 2	Saccharomyces cerevisiae S288C	121-125
618867-2	1978	The asparaginyl-tRNA synthetase in the mutant strain exhibits a greater temperature lability in vitro, a higher temperature-independent Km for asparagine, and a lower temperature-dependent catalytic capacity than the enzyme from the wild type strain.	Asparagine	143-153	asparagine--tRNA ligase, cytoplasmic	Cricetulus griseus	4-31
620046-3	1978	The location of Asn in position 6 has been considered as a specific property of liver glyceraldehyde-3-phosphate dehydrogenase (Kulbe, K.D., Jackson, K.W.	Asparagine	16-19	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	86-126
562233-6	1977	By methylation analysis of the oligosaccharide obtained by hydrazinolysis of the disialoglycopeptide, the L-fucose residues was found to be linked to C-6 of the 2-acetamido-2-deoxy-D-glucose residue linked to the asparagine residue.	Asparagine	213-223	complement C6	Homo sapiens	150-153
198803-0	1977	Enzyme regulation in neuroblastoma cells in a salts/glucose medium: induction of ornithine decarboxylase by asparagine and glutamine.	Asparagine	108-118	ornithine decarboxylase, structural 1	Mus musculus	81-104
198803-1	1977	L-Asparagine is necessary and sufficient for the maximal induction of ornithine decarboxylase (ODC) (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in confluent N18 mouse neuroblastoma cells in a salts/glucose medium; L-asparagine also induces maximal ODC activity when added to a tissue culture medium.	Asparagine	0-12	ornithine decarboxylase, structural 1	Mus musculus	70-93
198803-1	1977	L-Asparagine is necessary and sufficient for the maximal induction of ornithine decarboxylase (ODC) (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in confluent N18 mouse neuroblastoma cells in a salts/glucose medium; L-asparagine also induces maximal ODC activity when added to a tissue culture medium.	Asparagine	0-12	ornithine decarboxylase, structural 1	Mus musculus	95-98
198803-1	1977	L-Asparagine is necessary and sufficient for the maximal induction of ornithine decarboxylase (ODC) (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in confluent N18 mouse neuroblastoma cells in a salts/glucose medium; L-asparagine also induces maximal ODC activity when added to a tissue culture medium.	Asparagine	0-12	ornithine decarboxylase, structural 1	Mus musculus	254-257
198803-1	1977	L-Asparagine is necessary and sufficient for the maximal induction of ornithine decarboxylase (ODC) (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in confluent N18 mouse neuroblastoma cells in a salts/glucose medium; L-asparagine also induces maximal ODC activity when added to a tissue culture medium.	Asparagine	220-232	ornithine decarboxylase, structural 1	Mus musculus	70-93
198803-1	1977	L-Asparagine is necessary and sufficient for the maximal induction of ornithine decarboxylase (ODC) (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in confluent N18 mouse neuroblastoma cells in a salts/glucose medium; L-asparagine also induces maximal ODC activity when added to a tissue culture medium.	Asparagine	220-232	ornithine decarboxylase, structural 1	Mus musculus	95-98
198803-5	1977	In the salts/glucose medium, the rate of loss of ODC activity following the inhibition of protein synthesis by cycloheximide or puromycin depends upon the presence or absence of asparagine; loss is rapid only in the absence of asparagine and does not appear to be related to the inhibition of protein synthesis.	Asparagine	178-188	ornithine decarboxylase, structural 1	Mus musculus	49-52
198803-5	1977	In the salts/glucose medium, the rate of loss of ODC activity following the inhibition of protein synthesis by cycloheximide or puromycin depends upon the presence or absence of asparagine; loss is rapid only in the absence of asparagine and does not appear to be related to the inhibition of protein synthesis.	Asparagine	227-237	ornithine decarboxylase, structural 1	Mus musculus	49-52
186027-0	1976	Modification of diamine oxidase activity in vitro by metabolites of asparagine and differences in asparagine decarboxylation in normal and virus-transformed baby hamster kidney cells.	Asparagine	68-78	amine oxidase copper containing 1	Sus scrofa	16-31
892715-4	1977	This interpretation is based on the exchange of the 2,3-diphosphoglycerate contact beta2His leads to Asn from man to llama: the interaction between the heterotropic allosteric effector 2,3-diphosphoglycerate and protein is diminished, which results in higher oxygen affinity of the hemoglobin of llama.	Asparagine	101-104	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	83-88
15625886-1	1976	The asparagine analog, 5-diazo-4-oxo-L-norvaline is a substrate and an irreversible inhibitor of L-asparaginase.	Asparagine	4-14	asparaginase and isoaspartyl peptidase 1	Homo sapiens	97-111
16659859-8	1977	Amino acids or amino acid analogues added singly to the induction medium have a similar effect: i.e. when the induction of nitrate reductase is inhibited in the root tips (lysine, canavanine, azaserine, azetidine-2-carboxylic acid, dl-4-azaleucine, asparagine, and glutamine), that inhibition is more severe in mature root sections.	Asparagine	249-259	nitrate reductase [NADH] 1	Zea mays	123-140
186350-5	1976	Thus, in S5-27, substituting glutamine in position 9 or asparagine in position 15 makes the fragment more VIP-like but not less secretin-like.	Asparagine	56-66	vasoactive intestinal peptide	Homo sapiens	106-109
795426-1	1976	Preparations of yeast cell membranes can catalyse in vitro the N-acetyl-beta-D-glucosaminylation of the asparagine sequon at residues 34--36 of bovine pancreatic ribonuclease A.	Asparagine	104-114	ribonuclease	Saccharomyces cerevisiae S288C	162-174
823150-5	1976	During the sequence work on human carbonic anhydrase C, 3 very easily deamidated asparagine residues were noted, all occurring in -Asn-Gly- sequences.	Asparagine	81-91	carbonic anhydrase 2	Homo sapiens	34-54
823150-5	1976	During the sequence work on human carbonic anhydrase C, 3 very easily deamidated asparagine residues were noted, all occurring in -Asn-Gly- sequences.	Asparagine	131-134	carbonic anhydrase 2	Homo sapiens	34-54
1079112-9	1975	A carbohydrate chain could be prevented from attaching to the Z type either because of a conformational change or because of the replacement of a carbohydrate-binding asparagine residue in the Z protein.	Asparagine	167-177	transmembrane BAX inhibitor motif containing 4	Homo sapiens	193-202
241845-14	1975	These results indicate that while most of the immobilized L-asparaginase remains at the injection site, it produces a significant plasma L-asparagine depression and antitumor acitivity comparable to that of the native preparation without major toxicity.	Asparagine	137-149	asparaginase like 1	Mus musculus	58-72
1138883-0	1975	Haemoglobin Arya: alpha 2-47 (CD5), aspartic acid yields asparagine.	Asparagine	57-67	CD5 molecule	Homo sapiens	30-33
1138883-2	1975	The substitution is at residue 47 (CD5) of the alpha chain in which aspartic acid has been substituted by asparagine.	Asparagine	106-116	CD5 molecule	Homo sapiens	35-38
8429-4	1976	Both dihydropteridine reductase and phenylalanine hydroxylase activities were found to be higher in cells adapted to a medium containing L-phenylalanine or L-tyrosine as the sole carbon source than in those grown in L-asparagine.	Asparagine	216-228	quinoid dihydropteridine reductase	Homo sapiens	5-31
8429-4	1976	Both dihydropteridine reductase and phenylalanine hydroxylase activities were found to be higher in cells adapted to a medium containing L-phenylalanine or L-tyrosine as the sole carbon source than in those grown in L-asparagine.	Asparagine	216-228	phenylalanine hydroxylase	Homo sapiens	36-61
938666-7	1976	This analysis indicated that autoclaved ligament elastin contains approximately 18 glutamine, 3 asparagine, 4 glutamic acid and 5 aspartic acid residues per 1000 residues, in good agreement with the analysis of total acid-labile ammonia.	Asparagine	96-106	elastin	Homo sapiens	49-56
4643336-0	1972	The concentration of asparagine in the tissues of rats treated with growth hormone.	Asparagine	21-31	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
4462579-5	1974	Urate synthesis from glycine, glutamine, NH(4)Cl, asparagine, alanine, histidine and a mixture of 21 amino acids was obtained on inclusion of insulin in the perfusion medium.	Asparagine	50-60	insulin	Gallus gallus	142-149
4375805-0	1974	[A case of hemoglobin Korle Bu (beta 73(E17) Asp yields Asn) in the Ivory Coast.	Asparagine	56-59	small nucleolar RNA, H/ACA box 73A	Homo sapiens	32-43
1091734-2	1975	Four analogs of ovine somatostatin (SRIF, PSOMATOTROPIN RELEASE INhibiting factor), the sequence of which is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, have been synthesized by the solid-phase methodology.	Asparagine	127-130	somatostatin	Homo sapiens	22-34
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Asparagine	126-129	BOC cell adhesion associated, oncogene regulated	Homo sapiens	56-59
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Asparagine	126-129	BOC cell adhesion associated, oncogene regulated	Homo sapiens	112-115
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Asparagine	148-151	BOC cell adhesion associated, oncogene regulated	Homo sapiens	56-59
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Asparagine	148-151	BOC cell adhesion associated, oncogene regulated	Homo sapiens	112-115
807012-0	1975	Reduction of canine serum asparagine levels by L -asparaginase immobilized on collagen: a potential form of cancer chemotherapy.	Asparagine	26-36	asparaginase and isoaspartyl peptidase 1	Homo sapiens	47-62
4774404-0	1973	The potentiation of growth hormone by asparagine and tryptophan.	Asparagine	38-48	gonadotropin releasing hormone receptor	Rattus norvegicus	20-34
4774404-1	1973	Asparagine potentiates the growth-promoting effect of bovine growth hormone in rats when injected 3h after the latter, but not earlier.	Asparagine	0-10	gonadotropin releasing hormone receptor	Rattus norvegicus	61-75
19999712-3	1973	Lupin component II: Ala26, Arg1, (Asp + Asn)18, (Glu + Gln)20, Gly9, His5, Ile10, Leu16, Lys18, Met1, Phe8, Pro6, Ser12, Thr10, Trp3, Tyr2 and Val18.	Asparagine	40-43	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
5273889-3	1970	Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component.	Asparagine	164-174	oxytocin/neurophysin I prepropeptide	Homo sapiens	8-16
5553721-0	1971	Metabolism of asparagine, aspartate, glutamine, and glutamate in lymphoid tissue: basis for immunosuppression by L-asparaginase.	Asparagine	14-24	asparaginase and isoaspartyl peptidase 1	Homo sapiens	113-127
5280529-4	1971	A critical role is played by the asparagine residue: its peptide N-H participates in the formation of the hydrogen-bonded cyclic structure of the beta-turn in the ring component of oxytocin and its peptide C=O can be hydrogen-bonded to the N-H of tyrosine, while its side chain C=O stabilizes the second beta-turn by forming a hydrogen bond with the N-H of the leucine residue, which is part of the end peptide of the second beta-turn.	Asparagine	33-43	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
5355345-5	1969	The asparagine residue G10(108)beta lies in the internal cavity of the tetrameric molecule and its main chain carbonyl is thought to be hydrogen bonded to histidine G10(103)alpha at the region of contact between alpha- and beta-chains.	Asparagine	4-14	Fc gamma receptor and transporter	Homo sapiens	212-234
5526341-0	1970	L-asparaginase: early findings and current studies on the metabolism of L-asparagine in lymphoma cells.	Asparagine	72-84	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
5696551-3	1968	The amino-acid substitution was found to be a replacement of the asparagine residue by one of lysine in the 78th position of the 141 of the alpha-chain.	Asparagine	65-75	Fc gamma receptor and transporter	Homo sapiens	140-151
4894450-0	1969	Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.	Asparagine	60-70	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	34-48
4378033-6	1968	The great interest in L-asparaginase at the present time lies in the fact that certain neoplastic cells have a specific nutritional requirement for the amino acid L-asparagine, whereas no normal cells appear to have this requirement.	Asparagine	163-175	asparaginase and isoaspartyl peptidase 1	Homo sapiens	22-36
5971784-1	1966	Reinvestigation of the amino acid sequence of bovine chymotrypsinogen A suggests that the amino acid sequence at the N-terminus of the B-chain (residues 16-19) is -Ile-Val-Asn-Gly- rather than -Ile-Val-Gly-Asp- and that Ser-215 should be deleted.	Asparagine	172-175	chymotrypsinogen A	Bos taurus	53-71
16591538-0	1967	A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase.	Asparagine	34-44	glucose-6-phosphate dehydrogenase	Homo sapiens	126-159
5240831-1	1968	The L-asparagine analog, 5-diazo-4-oxo-L-norvaline, specifically inactivates L-asparaginase and inhibits the growth of L-asparagine-dependent or L-asparaginase-sensitive tumor cells in culture.	Asparagine	4-16	asparaginase and isoaspartyl peptidase 1	Homo sapiens	77-91
5240831-1	1968	The L-asparagine analog, 5-diazo-4-oxo-L-norvaline, specifically inactivates L-asparaginase and inhibits the growth of L-asparagine-dependent or L-asparaginase-sensitive tumor cells in culture.	Asparagine	4-16	asparaginase and isoaspartyl peptidase 1	Homo sapiens	145-159
5240831-1	1968	The L-asparagine analog, 5-diazo-4-oxo-L-norvaline, specifically inactivates L-asparaginase and inhibits the growth of L-asparagine-dependent or L-asparaginase-sensitive tumor cells in culture.	Asparagine	119-131	asparaginase and isoaspartyl peptidase 1	Homo sapiens	145-159
5689413-5	1968	Thus the requirement by certain malignant cells of exogenous asparagine, which entails sensitivity to asparaginase, may be ascribed to lack of asparagine synthetase.	Asparagine	61-71	asparagine synthetase	Mus musculus	143-164
16656225-5	1966	In addition, the results show that asparagine and the amino acids of the neutral and basic fraction were preferentially transported to the root tip region.	Asparagine	35-45	NAC domain-containing protein 74	Zea mays	144-147
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Asparagine	87-97	S100 calcium binding protein B	Homo sapiens	64-67
5902571-8	1966	Reasons are given for considering the prompt inhibition of protein synthesis in the asparagine-dependent -OG cells a direct result of asparagine-deprivation induced in vivo by the injected guinea pig serum, the L-asparaginase of which presumably converted the available L-asparagine of the host to L-aspartic acid that was not taken up by the -OG cells.	Asparagine	84-94	asparaginase like 1	Mus musculus	211-225
5902571-8	1966	Reasons are given for considering the prompt inhibition of protein synthesis in the asparagine-dependent -OG cells a direct result of asparagine-deprivation induced in vivo by the injected guinea pig serum, the L-asparaginase of which presumably converted the available L-asparagine of the host to L-aspartic acid that was not taken up by the -OG cells.	Asparagine	134-144	asparaginase like 1	Mus musculus	211-225
5902571-8	1966	Reasons are given for considering the prompt inhibition of protein synthesis in the asparagine-dependent -OG cells a direct result of asparagine-deprivation induced in vivo by the injected guinea pig serum, the L-asparaginase of which presumably converted the available L-asparagine of the host to L-aspartic acid that was not taken up by the -OG cells.	Asparagine	270-282	asparaginase like 1	Mus musculus	211-225
5902571-13	1966	The findings are considered in relation to the probability, disclosed in part by previous studies, that heated guinea pig serum brings about its effects upon Lymphoma 6C3HED-OG cells in vivo by providing active L-asparaginase in large amounts, which presumably converts the available (extracellular) asparagine of the host to aspartic acid, the latter not being taken up by the lymphoma cells in vivo or in vitro.	Asparagine	300-310	asparaginase like 1	Mus musculus	211-225
13237303-0	1954	Presence of glutamine and asparagine in enzymatic hydrolysates of oxytocin and vasopressin.	Asparagine	26-36	arginine vasopressin	Homo sapiens	79-90
33846803-4	2021	In an attempt to identify nutrients able to counteract glutamine deprivation effects, it was shown that, in the absence of glutamine, asparagine permitted cell survival and proliferation, and maintained c-Myc expression as in glutamine-fed cells, with high levels of canonical c-Myc and c-Myc 1 almost undetectable.	Asparagine	134-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	203-208
33846803-4	2021	In an attempt to identify nutrients able to counteract glutamine deprivation effects, it was shown that, in the absence of glutamine, asparagine permitted cell survival and proliferation, and maintained c-Myc expression as in glutamine-fed cells, with high levels of canonical c-Myc and c-Myc 1 almost undetectable.	Asparagine	134-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	277-282
33846803-5	2021	In asparagine-fed cells, global protein translation was higher than in glutamine-starved cells, and there was an increase in the levels of glutamine synthetase (GS), whose activity was essential for cellular viability and proliferation.	Asparagine	3-13	glutamate-ammonia ligase	Homo sapiens	139-159
33846803-5	2021	In asparagine-fed cells, global protein translation was higher than in glutamine-starved cells, and there was an increase in the levels of glutamine synthetase (GS), whose activity was essential for cellular viability and proliferation.	Asparagine	3-13	glutamate-ammonia ligase	Homo sapiens	161-163
33846803-6	2021	In glutamine-starved asparagine-fed cells, the inhibition of c-Myc activity led to a decrease in global protein translation and GS synthesis, suggesting an association between c-Myc expression, GS levels and cellular proliferation, mediated by asparagine when exogenous glutamine is absent.	Asparagine	21-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-66
33846803-6	2021	In glutamine-starved asparagine-fed cells, the inhibition of c-Myc activity led to a decrease in global protein translation and GS synthesis, suggesting an association between c-Myc expression, GS levels and cellular proliferation, mediated by asparagine when exogenous glutamine is absent.	Asparagine	21-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	176-181
33846803-6	2021	In glutamine-starved asparagine-fed cells, the inhibition of c-Myc activity led to a decrease in global protein translation and GS synthesis, suggesting an association between c-Myc expression, GS levels and cellular proliferation, mediated by asparagine when exogenous glutamine is absent.	Asparagine	21-31	glutamate-ammonia ligase	Homo sapiens	128-130
33846803-6	2021	In glutamine-starved asparagine-fed cells, the inhibition of c-Myc activity led to a decrease in global protein translation and GS synthesis, suggesting an association between c-Myc expression, GS levels and cellular proliferation, mediated by asparagine when exogenous glutamine is absent.	Asparagine	244-254	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-66
33846803-6	2021	In glutamine-starved asparagine-fed cells, the inhibition of c-Myc activity led to a decrease in global protein translation and GS synthesis, suggesting an association between c-Myc expression, GS levels and cellular proliferation, mediated by asparagine when exogenous glutamine is absent.	Asparagine	244-254	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	176-181
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Asparagine	136-139	reticulon 4	Rattus norvegicus	93-99
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Asparagine	136-139	Eph receptor A4	Rattus norvegicus	112-117
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Asparagine	136-139	reticulon 4	Rattus norvegicus	182-188
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Asparagine	136-139	Eph receptor A4	Rattus norvegicus	197-202
33846803-0	2021	Asparagine sustains cellular proliferation and c-Myc expression in glutamine-starved cancer cells.	Asparagine	0-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Asparagine	87-97	serine incorporator 5	Homo sapiens	169-176
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Asparagine	87-97	serine incorporator 5	Homo sapiens	261-268
33845472-0	2021	Role of pH in the synthesis and growth of gold nanoparticles using L-Asparagine: A combined experimental and simulation study.	Asparagine	67-79	phenylalanine hydroxylase	Homo sapiens	8-10
33845472-3	2021	In this work, we use L-Asparagine (Asn), an amino acid building block of large biomolecular systems, to synthesise gold nanoparticles (AuNPs) in aqueous solution at controlled pH.	Asparagine	21-33	phenylalanine hydroxylase	Homo sapiens	176-178
33845472-3	2021	In this work, we use L-Asparagine (Asn), an amino acid building block of large biomolecular systems, to synthesise gold nanoparticles (AuNPs) in aqueous solution at controlled pH.	Asparagine	35-38	phenylalanine hydroxylase	Homo sapiens	176-178
33822775-0	2021	Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.	Asparagine	16-26	CD8a molecule	Homo sapiens	81-84
34011547-3	2021	Currently, most of the information regarding the role of CoV Mac1 during infection is based on a single point mutation of a highly conserved asparagine residue, which makes contact with the distal ribose of ADP-ribose.	Asparagine	141-151	integrin subunit beta 2	Homo sapiens	61-65
34004061-2	2021	published in Nature Cell Biology which uncovered that asparagine (Asn), a non-essential amino acid in mammalians, is able to enhance the TCR-mediated activation and efficacy of CD8+ T cells towards tumour through lymphocyte-specific protein tyrosine kinase (LCK) signalling.	Asparagine	54-64	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	258-261
34004061-2	2021	published in Nature Cell Biology which uncovered that asparagine (Asn), a non-essential amino acid in mammalians, is able to enhance the TCR-mediated activation and efficacy of CD8+ T cells towards tumour through lymphocyte-specific protein tyrosine kinase (LCK) signalling.	Asparagine	66-69	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	258-261
33822775-4	2021	Asparagine (Asn) is a non-essential amino acid that can be synthesized intracellularly through the glutamine-hydrolyzing enzyme asparagine synthetase (ASNS).	Asparagine	0-10	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	128-149
33822775-4	2021	Asparagine (Asn) is a non-essential amino acid that can be synthesized intracellularly through the glutamine-hydrolyzing enzyme asparagine synthetase (ASNS).	Asparagine	0-10	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	151-155
33822775-4	2021	Asparagine (Asn) is a non-essential amino acid that can be synthesized intracellularly through the glutamine-hydrolyzing enzyme asparagine synthetase (ASNS).	Asparagine	12-15	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	128-149
33822775-4	2021	Asparagine (Asn) is a non-essential amino acid that can be synthesized intracellularly through the glutamine-hydrolyzing enzyme asparagine synthetase (ASNS).	Asparagine	12-15	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	151-155
33822775-5	2021	We set out to define the requirements for uptake of extracellular Asn and ASNS activity in CD8+ T cell activation.	Asparagine	66-69	CD8a molecule	Homo sapiens	91-94
33822775-6	2021	At early timepoints of activation in vitro, CD8+ T cells expressed little or no ASNS and, as a consequence, viability and TCR-stimulated growth, activation and metabolic reprogramming were substantially impaired under conditions of Asn deprivation.	Asparagine	232-235	CD8a molecule	Homo sapiens	44-47
33822775-7	2021	At later timepoints (>24h of activation), TCR-induced mTOR-dependent signals resulted in upregulation of ASNS, that endowed CD8+ T cells with the capacity to function independently of extracellular Asn.	Asparagine	198-201	mechanistic target of rapamycin kinase	Homo sapiens	54-58
33822775-7	2021	At later timepoints (>24h of activation), TCR-induced mTOR-dependent signals resulted in upregulation of ASNS, that endowed CD8+ T cells with the capacity to function independently of extracellular Asn.	Asparagine	198-201	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	105-109
33822775-8	2021	Thus, our data suggest that the coordinated upregulation of ASNS expression and uptake of extracellular Asn is involved in optimal T cell effector responses.	Asparagine	104-107	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	60-64
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	10-20	CREB regulated transcription coactivator 1	Mus musculus	77-83
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	165-175	CREB regulated transcription coactivator 1	Mus musculus	77-83
33609439-0	2021	Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.	Asparagine	0-10	activating transcription factor 4	Homo sapiens	48-52
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	165-175	activating transcription factor 4	Homo sapiens	211-215
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	10-20	activating transcription factor 4	Homo sapiens	45-49
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	10-20	CREB regulated transcription coactivator 1	Mus musculus	54-60
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	10-20	CREB regulated transcription coactivator 1	Mus musculus	77-83
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	10-20	activating transcription factor 4	Homo sapiens	211-215
33609439-4	2021	Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1.	Asparagine	165-175	CREB regulated transcription coactivator 1	Mus musculus	77-83
33887099-1	2021	Aspartate/asparagine-beta-hydroxylase (AspH) is a human 2-oxoglutarate (2OG) and Fe(II) oxygenase that catalyzes C3 hydroxylations of aspartate/asparagine residues of epidermal growth factor-like domains (EGFDs).	Asparagine	10-20	aspartate beta-hydroxylase	Homo sapiens	39-43
33620458-4	2021	First, we found that Agp1 underwent ubiquitination and endocytosis in response to the addition of excess asparagine which is a substrate of Agp1.	Asparagine	105-115	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	21-25
33620458-4	2021	First, we found that Agp1 underwent ubiquitination and endocytosis in response to the addition of excess asparagine which is a substrate of Agp1.	Asparagine	105-115	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	140-144
33788965-4	2021	Biochemical analyses of the two subunits following site-directed mutagenesis and pharmacological treatments established that both CALHM1 and 3 were N-glycosylated at single Asn residues in their second extracellular loops.	Asparagine	173-176	calcium homeostasis modulator 1	Homo sapiens	130-142
33931042-16	2021	When the sequences of eight genes whose expression was downregulated and four genes whose expression was upregulated were compared, SKIP14, an F-box protein whose sequence is 85% homologous to that of SLY1 in Arabidopsis, presented an amino acid change (from Ser to Asn) and was expressed at a lower level in the stems of the ftdm mutant compared with the WT.	Asparagine	266-269	F-box family protein	Arabidopsis thaliana	201-205
33921837-9	2021	SNP association analysis showed that only SNP rs404360094 in the exon 3 of the CD226 gene, which produces an amino acid substitution from asparagine (uncharged polar) to aspartic acid (acidic), was associated with the three seasonality traits.	Asparagine	138-148	CD226 antigen	Ovis aries	79-84
33120427-8	2021	1) low MYC mRNA expression and 2) false-negative immunohistochemistry (IHC) staining mediated by a single nucleotide polymorphism resulting in an asparagine to serine substitution at the 11th amino acid residue of MYC (MYC-N11S).	Asparagine	146-156	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	214-217
33120427-8	2021	1) low MYC mRNA expression and 2) false-negative immunohistochemistry (IHC) staining mediated by a single nucleotide polymorphism resulting in an asparagine to serine substitution at the 11th amino acid residue of MYC (MYC-N11S).	Asparagine	146-156	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	219-227
33788548-8	2021	Importantly, the Asn-containing linkers were shown to be completely stable to human neutrophil elastase, an enzyme thought to be responsible for the neutropenia and thrombocytopenia associated with ValCitPABC-MMAE ADCs.	Asparagine	17-20	elastase, neutrophil expressed	Homo sapiens	84-103
33392644-0	2021	Disruption of asparagine-linked glycosylation to rescue and alter gating of the NaV1.5-Na+ channel.	Asparagine	14-24	sodium voltage-gated channel alpha subunit 5	Homo sapiens	80-86
32978718-1	2021	Legumain is a newly discovered lysosomal cysteine protease that can cleave asparagine bonds and plays crucial roles in regulating immunity and cancer metastasis.	Asparagine	75-85	legumain	Homo sapiens	0-8
33911966-1	2021	L-Asparaginase is an antileukemic agent that depletes L-asparagine "an important nutrient for cancer cells" through the hydrolysis of L-asparagine into L-aspartic acid and ammonia leading to leukemia cell starvation and apoptosis in susceptible leukemic cell populations.	Asparagine	54-66	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
33911966-1	2021	L-Asparaginase is an antileukemic agent that depletes L-asparagine "an important nutrient for cancer cells" through the hydrolysis of L-asparagine into L-aspartic acid and ammonia leading to leukemia cell starvation and apoptosis in susceptible leukemic cell populations.	Asparagine	134-146	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
33722201-4	2021	The purpose of the current study was to determine the biological significance of the putative aatJ-aatQMP operon and its regulatory aauR and rpoN genes in the utilization of L-glutamate, L-glutamine, L-aspartate and L-asparagine in Pseudomonas aeruginosa PAO1.	Asparagine	216-228	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	141-145
33821264-3	2021	Currently, most of the information regarding the role of CoV Mac1 during infection is based on a single point mutant of a highly conserved asparagine-to-alanine mutation, which is known to largely eliminate Mac1 ADP-ribosylhydrolase activity.	Asparagine	139-149	integrin subunit beta 2	Homo sapiens	61-65
33821264-3	2021	Currently, most of the information regarding the role of CoV Mac1 during infection is based on a single point mutant of a highly conserved asparagine-to-alanine mutation, which is known to largely eliminate Mac1 ADP-ribosylhydrolase activity.	Asparagine	139-149	integrin subunit beta 2	Homo sapiens	207-211
33709700-5	2021	By profiling O-GlcNAc in cell extracts and probing glycosylation of purified substrates, we show here that ladders of asparagines and aspartates that extend the full length of OGT"s TPR lumen control substrate glycosylation.	Asparagine	118-129	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	176-179
33722201-8	2021	Subsequent analysis of beta-galactosidase reporters revealed that both aatJ and aatQ were induced in response to L-glutamate, L-glutamine, L-aspartate or L-asparagine in a manner dependent on the aauR and rpoN genes.	Asparagine	154-166	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	205-209
33554439-0	2021	MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction.	Asparagine	63-73	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
33554439-3	2021	Here we show that MAPK signaling activation in asparagine-restricted melanoma cells impairs GSK3-beta-mediated c-MYC degradation.	Asparagine	47-57	glycogen synthase kinase 3 alpha	Homo sapiens	92-101
33554439-3	2021	Here we show that MAPK signaling activation in asparagine-restricted melanoma cells impairs GSK3-beta-mediated c-MYC degradation.	Asparagine	47-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-116
33554439-4	2021	In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells.	Asparagine	229-239	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
33554439-4	2021	In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells.	Asparagine	229-239	activating transcription factor 4	Homo sapiens	33-37
33554439-4	2021	In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells.	Asparagine	229-239	CREB regulated transcription coactivator 1	Mus musculus	210-216
33554439-5	2021	Blocking the MAPK-c-MYC-SLC7A5 signaling axis cooperates with asparagine restriction to effectively suppress melanoma cell proliferation.	Asparagine	62-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
33554439-5	2021	Blocking the MAPK-c-MYC-SLC7A5 signaling axis cooperates with asparagine restriction to effectively suppress melanoma cell proliferation.	Asparagine	62-72	solute carrier family 7 member 5	Homo sapiens	24-30
33685385-1	2021	L-asparaginase (L-asparagine amino hydrolase, E.C.3.5.1.1) is the most important chemotherapeutic drug used in treating Acute Lymphocytic Leukemia (ALL), decreasing blood asparagine rates causing apoptosis in tumor cells.	Asparagine	18-28	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
32926180-8	2021	Asparagine to glutamine mutants, which cannot undergo N-glycosylation, at each of three putative N-glycosylation sites in hTau (N167Q, N359Q, and N410Q) were generated and expressed in SH-SY5Y cells and in transgenic Drosophila.	Asparagine	0-10	microtubule associated protein tau	Homo sapiens	122-126
33508424-11	2021	Strikingly, suppressed CCT3 shifted intracellular levels of glutamine, beta-alanine, glycine, serin, asparagine and sarcosine, which are employed in energy metabolism.	Asparagine	101-111	chaperonin containing TCP1 subunit 3	Homo sapiens	23-27
33481349-6	2021	Tumor necrosis factor alpha-treatment (TNFalpha) of HUVECs causes increases in asparagine and decreases in aspartate concentrations.	Asparagine	79-89	tumor necrosis factor	Homo sapiens	0-27
33481349-6	2021	Tumor necrosis factor alpha-treatment (TNFalpha) of HUVECs causes increases in asparagine and decreases in aspartate concentrations.	Asparagine	79-89	tumor necrosis factor	Homo sapiens	39-47
33528599-6	2021	A previously identified Asn-to-Lys anticodon shift substitution in D. ananassae may have arisen to compensate for the convergent and parallel gains of C17 in tRNAAsn paralogs in that lineage.	Asparagine	24-27	transfer RNA:Asparagine-GTT 1-1	Drosophila melanogaster	158-165
33408177-6	2021	However, PR8 NS1 S205N showed a remarkably higher attenuation compared to PR8 NS1 S205G in a human cell line, highlighting a potential host independent advantage of phosphorylatable S205, while an asparagine at this position leads to a potential host-specific attenuation.	Asparagine	197-207	Nucleostemin 1	Drosophila melanogaster	13-16
33611850-1	2021	HLA-DPA1*01:46 differs from HLA-DPA1*01:03 in exon 2 at amino acid 85; Aspartate to Asparagine substitution.	Asparagine	84-94	major histocompatibility complex, class II, DP alpha 1	Homo sapiens	0-8
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Asparagine	149-159	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	6-9
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Asparagine	149-159	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	68-71
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Asparagine	149-159	O-GlcNAcase	Homo sapiens	72-75
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Asparagine	149-159	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	68-71
33615182-1	2021	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu.	Asparagine	0-10	asparaginase and isoaspartyl peptidase 1	Homo sapiens	26-40
33615182-1	2021	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu.	Asparagine	0-10	asparaginase and isoaspartyl peptidase 1	Homo sapiens	42-50
33615182-1	2021	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu.	Asparagine	0-10	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	171-175
33615182-1	2021	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu.	Asparagine	212-222	asparaginase and isoaspartyl peptidase 1	Homo sapiens	42-50
33615182-1	2021	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu.	Asparagine	212-222	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	171-175
33615182-12	2021	Importantly, pharmacological inhibition of such nodes synergizes with l-asparaginase-mediated asparagine deprivation in ASNS deficient cells suggesting novel potential therapeutic combinations in melanoma.	Asparagine	94-104	asparaginase and isoaspartyl peptidase 1	Homo sapiens	70-84
33615182-12	2021	Importantly, pharmacological inhibition of such nodes synergizes with l-asparaginase-mediated asparagine deprivation in ASNS deficient cells suggesting novel potential therapeutic combinations in melanoma.	Asparagine	94-104	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	120-124
33436626-7	2021	Structural and biochemical analyses reveal TSC2 GAP-Rheb complimentary interactions and suggest a catalytic mechanism, by which an asparagine thumb (N1643) stabilizes gamma-phosphate of GTP and accelerate GTP hydrolysis of Rheb.	Asparagine	131-141	TSC complex subunit 2	Homo sapiens	43-47
33436626-7	2021	Structural and biochemical analyses reveal TSC2 GAP-Rheb complimentary interactions and suggest a catalytic mechanism, by which an asparagine thumb (N1643) stabilizes gamma-phosphate of GTP and accelerate GTP hydrolysis of Rheb.	Asparagine	131-141	Ras homolog, mTORC1 binding	Homo sapiens	52-56
33436626-7	2021	Structural and biochemical analyses reveal TSC2 GAP-Rheb complimentary interactions and suggest a catalytic mechanism, by which an asparagine thumb (N1643) stabilizes gamma-phosphate of GTP and accelerate GTP hydrolysis of Rheb.	Asparagine	131-141	Ras homolog, mTORC1 binding	Homo sapiens	223-227
33227824-2	2021	An asparagine (Asn)-linked N-acetylglucosamine (GlcNAc) of CTR ECD N130 was previously reported to enhance peptide hormone binding affinity for CTR ECD.	Asparagine	3-13	calcitonin receptor	Homo sapiens	59-62
33518769-1	2021	Asparagine synthetase catalyses the transfer of an amino group from glutamine to aspartate to form glutamate and asparagine.	Asparagine	113-123	LOC100856906	Zea mays	0-21
33227824-2	2021	An asparagine (Asn)-linked N-acetylglucosamine (GlcNAc) of CTR ECD N130 was previously reported to enhance peptide hormone binding affinity for CTR ECD.	Asparagine	15-18	calcitonin receptor	Homo sapiens	59-62
33391421-1	2021	Introduction: Previous studies have shown that peptides containing the asparagine-glycine-arginine (NGR) sequence can specifically bind to CD13 (aminopeptidase N) receptor, a tumor neovascular biomarker that is over-expressed on the surface of angiogenic blood vessels and various tumor cells, and it plays an important role in angiogenesis and tumor progression.	Asparagine	71-81	reticulon 4 receptor	Mus musculus	100-103
33391421-1	2021	Introduction: Previous studies have shown that peptides containing the asparagine-glycine-arginine (NGR) sequence can specifically bind to CD13 (aminopeptidase N) receptor, a tumor neovascular biomarker that is over-expressed on the surface of angiogenic blood vessels and various tumor cells, and it plays an important role in angiogenesis and tumor progression.	Asparagine	71-81	alanyl (membrane) aminopeptidase	Mus musculus	139-143
33323039-8	2020	The ARG and ASN were found to be important residues of REV.	Asparagine	12-15	Rev	Human immunodeficiency virus 1	55-58
33217155-2	2021	It is caused by homozygous/compound heterozygous variants in the aspartate/asparagine-beta-hydroxylase (ASPH) gene, which hydroxylates the aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.	Asparagine	75-85	aspartate beta-hydroxylase	Homo sapiens	104-108
33374431-11	2020	In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP.	Asparagine	13-23	prion protein	Canis lupus familiaris	44-47
33374431-11	2020	In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP.	Asparagine	13-23	prion protein	Canis lupus familiaris	133-136
33332443-9	2020	Single Nucleotide Polymorphism (SNP, rs324981) Asn107Ile of NPSR1gene, that switches an amino acid from Asn to Ile, has been found associated with increased susceptibility to obesity in Pakistani individuals.	Asparagine	47-50	neuropeptide S receptor 1	Homo sapiens	60-65
33420487-0	2021	LCK senses asparagine for T cell activation.	Asparagine	11-21	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
33420490-0	2021	Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses.	Asparagine	0-10	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
33420490-0	2021	Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses.	Asparagine	0-10	CD8a molecule	Homo sapiens	49-52
33420490-3	2021	Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in vivo.	Asparagine	10-13	CD8a molecule	Homo sapiens	29-32
33420490-4	2021	Conversely, restriction of dietary Asn, ASNase administration or inhibition of the Asn transporter SLC1A5 impairs the activity and responses of CD8+ T cells.	Asparagine	35-38	CD8a molecule	Homo sapiens	144-147
33420490-5	2021	Mechanistically, Asn does not directly alter cellular metabolic fluxes; it instead binds the SRC-family protein tyrosine kinase LCK and orchestrates LCK phosphorylation at Tyr 394 and 505, thereby leading to enhanced LCK activity and T-cell-receptor signalling.	Asparagine	17-20	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
33420490-5	2021	Mechanistically, Asn does not directly alter cellular metabolic fluxes; it instead binds the SRC-family protein tyrosine kinase LCK and orchestrates LCK phosphorylation at Tyr 394 and 505, thereby leading to enhanced LCK activity and T-cell-receptor signalling.	Asparagine	17-20	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	149-152
33420490-5	2021	Mechanistically, Asn does not directly alter cellular metabolic fluxes; it instead binds the SRC-family protein tyrosine kinase LCK and orchestrates LCK phosphorylation at Tyr 394 and 505, thereby leading to enhanced LCK activity and T-cell-receptor signalling.	Asparagine	17-20	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	149-152
33420490-6	2021	Thus, our findings reveal a critical and metabolism-independent role for Asn in the direct modulation of the adaptive immune response by controlling T-cell activation and efficacy, and further uncover that LCK is a natural Asn sensor signalling Asn sufficiency to T-cell functions.	Asparagine	223-226	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	206-209
33420490-6	2021	Thus, our findings reveal a critical and metabolism-independent role for Asn in the direct modulation of the adaptive immune response by controlling T-cell activation and efficacy, and further uncover that LCK is a natural Asn sensor signalling Asn sufficiency to T-cell functions.	Asparagine	223-226	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	206-209
33252732-5	2021	To-date, two families of GT-Cs involved in protein glycosylation have been structurally characterized: the family represented by PglB, AglB, and Stt3, which catalyzes oligosaccharide transfer to Asn, and the family represented by Pmt1 and Pmt2, which catalyzes mannose transfer to Thr or Ser.	Asparagine	195-198	epiphycan	Homo sapiens	129-133
33347861-6	2022	Several mammalian transaminases can catalyze transamination of asparagine, one of which - alanine-glyoxylate aminotransferase type 1 (AGT1) - is important in glyoxylate metabolism.	Asparagine	63-73	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	90-132
33347861-6	2022	Several mammalian transaminases can catalyze transamination of asparagine, one of which - alanine-glyoxylate aminotransferase type 1 (AGT1) - is important in glyoxylate metabolism.	Asparagine	63-73	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	134-138
33206527-10	2020	To investigate the regulatory effect of the N79 glycan on cellular growth, we mutated the single N-glycosylation site in CES1 from Asn to Gln (CES1-N79Q) via site-directed mutagenesis.	Asparagine	131-134	carboxylesterase 1	Homo sapiens	121-125
33364202-10	2020	Three-dimensional modeling of the claudin-8 structure identified an exposed HtrA cleavage site between the amino acids alanine 58 and asparagine 59, which is in well agreement with the mapping studies.	Asparagine	134-144	claudin 8	Homo sapiens	34-43
33364202-10	2020	Three-dimensional modeling of the claudin-8 structure identified an exposed HtrA cleavage site between the amino acids alanine 58 and asparagine 59, which is in well agreement with the mapping studies.	Asparagine	134-144	HtrA serine peptidase 1	Homo sapiens	76-80
32971086-0	2020	Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing alpha-synuclein aggregation and neuroinflammation.	Asparagine	0-10	synuclein alpha	Homo sapiens	108-123
33310702-3	2021	CD16a is heavily processed and recent reports indicate that the composition of the five CD16a asparagine(N)-linked carbohydrates (glycans) impacts affinity.	Asparagine	94-104	Fc gamma receptor IIIa	Homo sapiens	0-5
33310702-3	2021	CD16a is heavily processed and recent reports indicate that the composition of the five CD16a asparagine(N)-linked carbohydrates (glycans) impacts affinity.	Asparagine	94-104	Fc gamma receptor IIIa	Homo sapiens	88-93
33280590-10	2022	RESULTS: Eight amino acid levels (methionine, arginine, cystine, glutamine, proline, asparagine, serine, aspartate) were significantly altered in patients with neurofibromatosis type 1.	Asparagine	85-95	neurofibromin 1	Homo sapiens	160-184
33206527-10	2020	To investigate the regulatory effect of the N79 glycan on cellular growth, we mutated the single N-glycosylation site in CES1 from Asn to Gln (CES1-N79Q) via site-directed mutagenesis.	Asparagine	131-134	carboxylesterase 1	Homo sapiens	143-147
33091580-4	2020	The GP5 protein of GD1909 strain has an asparagine insertion at position 60 and has more complex glycosylation pattern.	Asparagine	40-50	glycoprotein V platelet	Homo sapiens	4-7
33276691-0	2020	Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation.	Asparagine	91-101	voltage-dependent anion channel 1	Mus musculus	44-49
33276691-0	2020	Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation.	Asparagine	91-101	superoxide dismutase 1, soluble	Mus musculus	57-61
33276691-5	2020	We found selective deamidations of asparagine and glutamine of VDAC1 in ALS-related NSC34-SOD1G93A cells but not in NSC34-SOD1WT or NSC34 cells.	Asparagine	35-45	superoxide dismutase 1, soluble	Mus musculus	90-94
33343327-4	2020	Interestingly, this gene cluster contains a non-synonymous single-nucleotide polymorphism (SNP) in the human CHRNA5 gene, causing an aspartic acid (D) to asparagine (N) substitution at amino acid position 398 in the alpha5 nAChR subunit.	Asparagine	154-164	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	109-115
33167336-5	2020	Osteoblastogenesis also triggers the induction of glutamine-dependent asparagine synthetase (ASNS), and, among non-essential amino acids, asparagine rescues differentiation of glutamine-starved MSCs, by restoring the transcriptional profiles of differentiating MSCs altered by glutamine starvation.	Asparagine	70-80	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	93-97
33329669-5	2020	Consistently, metabolite profiling disclosed that the total amount of key N metabolites like glutamate, glutamine, and asparagine were higher in CDF3-overexpressing plants, but lower in cdf3-1 in N limiting conditions.	Asparagine	119-129	cycling DOF factor 3	Arabidopsis thaliana	145-149
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Asparagine	194-204	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Asparagine	194-204	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
33214970-13	2020	Three individuals had Asparagine Aspartic Acid mutation at position 376 (A G), of which G6PD A(+) and G6PD A(-) were present in two and one cases, respectively.	Asparagine	22-32	glucose-6-phosphate dehydrogenase	Homo sapiens	88-92
33214970-13	2020	Three individuals had Asparagine Aspartic Acid mutation at position 376 (A G), of which G6PD A(+) and G6PD A(-) were present in two and one cases, respectively.	Asparagine	22-32	glucose-6-phosphate dehydrogenase	Homo sapiens	102-106
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	Asparagine	157-167	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	Asparagine	157-167	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
33045166-1	2020	We report herein an efficient chemical synthesis of homogeneous human E-cadherin N-linked glycopeptides consisting of a heptapeptide sequence adjacent to the Asn-633 N-glycosylation site with representative N-glycan structures, including a conserved trisaccharide, a core-fucosylated tetrasaccharide, and a complex-type biantennary octasaccharide.	Asparagine	158-161	cadherin 1	Homo sapiens	70-80
33248600-9	2020	Reduced neAA concentrations in CP160 decreased ADG and G:F. Supplementation of Asp+Asn, Glu, and Glu+Gln to CP160 increased ADG and G:F, but not to the level found for CP180.	Asparagine	83-86	ADG	Gallus gallus	124-127
33248600-11	2020	Supplementation of Asp+Asn caused higher ADG and G:F than supplementation of Asp alone.	Asparagine	23-26	ADG	Gallus gallus	41-44
32573712-4	2020	Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, while ALL cells are unable to synthesize adequate amounts of asparagine.	Asparagine	39-49	asparagine synthetase	Mus musculus	53-74
32573712-4	2020	Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, while ALL cells are unable to synthesize adequate amounts of asparagine.	Asparagine	39-49	asparagine synthetase	Mus musculus	76-80
32573712-4	2020	Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, while ALL cells are unable to synthesize adequate amounts of asparagine.	Asparagine	53-63	asparagine synthetase	Mus musculus	76-80
33184287-5	2020	All-atom molecular dynamics simulations indicate that the FUS-LC-C fibril core is stabilized by a plethora of hydrogen bonds involving sidechains of Gln, Asn, Ser, and Tyr residues, both along and transverse to the fibril growth direction, including diverse sidechain-to-backbone, sidechain-to-sidechain, and sidechain-to-water interactions.	Asparagine	154-157	FUS RNA binding protein	Homo sapiens	58-61
33176830-3	2020	Previous studies have documented the importance of asparagine (N)-linked glycosylation and identified several asparagine residues within the canonical consensus sequence N-X-S/T that is essential for the expression and function of Cav3.2 channels.	Asparagine	51-61	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	231-237
33176830-3	2020	Previous studies have documented the importance of asparagine (N)-linked glycosylation and identified several asparagine residues within the canonical consensus sequence N-X-S/T that is essential for the expression and function of Cav3.2 channels.	Asparagine	110-120	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	231-237
33176830-5	2020	Using a combination of electrophysiological recordings and surface biotinylation assays, we show that asparagines N345 and N1780 located in the motifs NVC and NPC, respectively, are essential for the expression of the human Cav3.2 channel in the plasma membrane.	Asparagine	102-113	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	224-230
33176830-6	2020	Therefore, these newly identified asparagine residues within non-canonical motifs add to those previously reported in canonical sites and suggest that N-glycosylation of Cav3.2 may also occur at non-canonical motifs to control expression of the channel in the plasma membrane.	Asparagine	34-44	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	170-176
32199697-5	2020	RESULTS: The liver expression levels of APOA1bp were associated with lower cIMT and leukocyte counts, a better plasma lipid profile and higher circulating levels of metabolites associated with lower risk of atherosclerosis (glycine, histidine and asparagine).	Asparagine	247-257	NAD(P)HX epimerase	Homo sapiens	40-47
32869445-12	2020	Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp-206, Thr-208, Asn-211, Glu-297, Lys-294, and Tyr-293.	Asparagine	97-100	mitogen-activated protein kinase kinase kinase 7	Mus musculus	42-46
32750331-4	2020	Although EphA2 knockdown delayed this progression, the delay was rescued by an EphA2 mutant expression with an Asp739 to Asn substitution, as well as by wild-type EphA2.	Asparagine	121-124	EPH receptor A2	Homo sapiens	9-14
32750331-4	2020	Although EphA2 knockdown delayed this progression, the delay was rescued by an EphA2 mutant expression with an Asp739 to Asn substitution, as well as by wild-type EphA2.	Asparagine	121-124	EPH receptor A2	Homo sapiens	79-84
32750331-4	2020	Although EphA2 knockdown delayed this progression, the delay was rescued by an EphA2 mutant expression with an Asp739 to Asn substitution, as well as by wild-type EphA2.	Asparagine	121-124	EPH receptor A2	Homo sapiens	79-84
33066323-0	2020	Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis.	Asparagine	20-30	myelin oligodendrocyte glycoprotein	Mus musculus	61-96
32827291-2	2020	Herein, we identify two asparagine-linked glycosylation sites in B4GalT4.	Asparagine	24-34	beta-1,4-galactosyltransferase 4	Homo sapiens	65-72
32623356-5	2020	In cells, HMGB1 is N-glycosylated at three asparagine residues located in boxes A and B, and these N-glycans are essential for the nucleocytoplasmic transport of the protein.	Asparagine	43-53	high mobility group box 1	Homo sapiens	10-15
33082972-4	2020	The mutation was mapped to the phytochromobilin synthase gene AUREA (AU), in which a single amino acid substitution from asparagine to tyrosine occurred.	Asparagine	121-131	phytochromobilin synthase	Solanum lycopersicum	31-56
33082972-4	2020	The mutation was mapped to the phytochromobilin synthase gene AUREA (AU), in which a single amino acid substitution from asparagine to tyrosine occurred.	Asparagine	121-131	phytochromobilin synthase	Solanum lycopersicum	62-67
32869445-12	2020	Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp-206, Thr-208, Asn-211, Glu-297, Lys-294, and Tyr-293.	Asparagine	97-100	mitogen-activated protein kinase kinase kinase 7	Mus musculus	61-65
32812680-7	2020	The Hsp90 Asp93 Asn substitution has long been known to abolish nucleotide binding, yet puzzlingly, native sequences of structurally similar ATPases, such as Topoisomerasese II, have an asparagine at this same crucial site.	Asparagine	186-196	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
32812680-8	2020	While aspartate and asparagine sidechains can both act as hydrogen bond acceptors, we show that a steric clash prevents the Hsp90 Asp93 Asn sidechain from adopting the necessary rotamer, whereas this steric restriction is absent in Topoisomerasese II.	Asparagine	20-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	124-129
32985550-8	2020	Detailed analysis of the sequential order of these rotamerizations suggests that an allosteric mechanism, involving the outward motion of an asparagine residue in transmembrane helix 3, might be a prerequisite to the large scale conformational transition of CXCR4.	Asparagine	141-151	C-X-C motif chemokine receptor 4	Homo sapiens	258-263
33117129-3	2020	L-asparaginase (L-ASNase) has been developed for therapeutic applications in many fields because it catalyzes the hydrolysis of asparagine and glutamine in cancer cells, which may also activate autophagy and induce the degradation of accumulated alpha-Syn.	Asparagine	128-138	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
32774853-12	2020	Asn exposure also increased both the RNA and protein expression of the HBP regulator GFPT2, which is a transcriptional target of sXBP1.	Asparagine	0-3	glutamine-fructose-6-phosphate transaminase 2	Homo sapiens	85-90
32753553-2	2020	By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at buried sites.	Asparagine	118-128	angiotensin converting enzyme 2	Homo sapiens	40-44
32753553-2	2020	By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at buried sites.	Asparagine	118-128	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	59-60
32800652-2	2020	The de novo synthesis of Asn in the pancreas occurs through the enzyme asparagine synthetase (ASNS).	Asparagine	25-28	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	71-92
32800652-2	2020	The de novo synthesis of Asn in the pancreas occurs through the enzyme asparagine synthetase (ASNS).	Asparagine	25-28	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	94-98
32800652-8	2020	We will offer the overarching perspective that a high abundance of ASNS expression is hardwired in the exocrine pancreas to buffer the high demands of Asn for pancreatic digestive enzyme protein synthesis, that perturbations in the ability to express or upregulate ASNS could tip the balance towards pancreatitis, and that pancreatic cancers exploit ASNS to gain a metabolic survival advantage.	Asparagine	151-154	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	67-71
32774853-10	2020	Asn in combination with Gln, but not Asn or Gln alone, stimulated expression of genes associated with the endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in UOK262 to a greater extent than in FH-restored cells.	Asparagine	0-3	fumarate hydratase	Homo sapiens	218-220
32544330-2	2020	Ribonucle-ase 1 (RNase 1), which is the human homolog of the archetypal enzyme RNase A, undergoes N-linked glycosylation at as-paragine residues 34, 76, and 88.	Asparagine	124-135	ribonuclease A family member 1, pancreatic	Homo sapiens	79-86
32912024-2	2020	An abnormal pattern compatible with a Hb A2 variant was observed on capillary electrophoresis (CE); direct sequencing revealed a transition at codon 89 of the delta gene (HBD: c.269G>A) changing serine into asparagine.	Asparagine	207-217	HBD	Homo sapiens	171-174
32502382-3	2020	We present the crystal structure of the catalytic asparagine-thumb GAP domain of TSC2.	Asparagine	50-60	TSC complex subunit 2	Homo sapiens	81-85
32664451-6	2020	In Cndp1-KO mice at week 11, renal asparagine, serine and glutamine levels and at week 55, renal arginine concentration were reduced.	Asparagine	35-45	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	3-8
32707027-1	2021	L-Asparaginase is an important enzyme which converts L-asparagine to L-aspartate and ammonia.	Asparagine	53-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
32707027-8	2021	The production medium for the maximum L-asparaginase specific activity (8500+-578U/mg) was as follows (g/L): L-asparagine (7.50), NaNO3 (0.50), MgSO4.7H2O (0.80), KCl (0.80) associated with an incubation period of 5 days, inoculum size of 5.60 %, and pH (7.0).	Asparagine	109-121	asparaginase and isoaspartyl peptidase 1	Homo sapiens	38-52
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Asparagine	27-37	angiotensin converting enzyme 2	Homo sapiens	108-112
32462673-4	2020	The mechanism of interaction and activation of MPL by mutant CALR is unique, not only due to the latter forming a homomultimeric complex through a novel mutant-specific sequence generated by frameshift mutation, but also for its ability to interact with immature asparagine-linked glycan for eventual engagement with immature MPL in the endoplasmic reticulum.	Asparagine	263-273	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	47-50
32462673-4	2020	The mechanism of interaction and activation of MPL by mutant CALR is unique, not only due to the latter forming a homomultimeric complex through a novel mutant-specific sequence generated by frameshift mutation, but also for its ability to interact with immature asparagine-linked glycan for eventual engagement with immature MPL in the endoplasmic reticulum.	Asparagine	263-273	calreticulin	Homo sapiens	61-65
32462673-4	2020	The mechanism of interaction and activation of MPL by mutant CALR is unique, not only due to the latter forming a homomultimeric complex through a novel mutant-specific sequence generated by frameshift mutation, but also for its ability to interact with immature asparagine-linked glycan for eventual engagement with immature MPL in the endoplasmic reticulum.	Asparagine	263-273	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	326-329
32721246-5	2020	Knockout of PBK dramatically suppressed in vivo tumor growth in MM cells, while genome editing of PBK changing from asparagine to serine substitution (rs3779620) slightly suppresses the tumor formation.	Asparagine	116-126	PDZ binding kinase	Homo sapiens	98-101
32434038-1	2020	Human L-asparaginase-like protein 1 (ASRGL1) has hydrolytic activity against L-asparagine and isoaspartyl dipeptides.	Asparagine	77-89	asparaginase and isoaspartyl peptidase 1	Homo sapiens	6-35
32434038-1	2020	Human L-asparaginase-like protein 1 (ASRGL1) has hydrolytic activity against L-asparagine and isoaspartyl dipeptides.	Asparagine	77-89	asparaginase and isoaspartyl peptidase 1	Homo sapiens	37-43
32602701-4	2020	Abolishing N-linked glycosylation by tunicamycin, glucosamine supplementation, or glutamine substitutions of all four potential Asn glycosylation sites blocked myonectin secretion.	Asparagine	128-131	erythroferrone	Homo sapiens	160-169
32709014-6	2020	GPR176 undergoes asparagine (N)-linked glycosylation, a post-translational modification required for its proper cell-surface expression.	Asparagine	17-27	G protein-coupled receptor 176	Homo sapiens	0-6
32482891-6	2020	Using site-directed mutagenesis, we determined that glycosylation of Asn-471 and Asn-1030 is necessary for ACLP secretion and identified a specific N-terminal proteolytic ACLP fragment.	Asparagine	69-72	AE binding protein 1	Homo sapiens	107-111
32482891-6	2020	Using site-directed mutagenesis, we determined that glycosylation of Asn-471 and Asn-1030 is necessary for ACLP secretion and identified a specific N-terminal proteolytic ACLP fragment.	Asparagine	69-72	AE binding protein 1	Homo sapiens	171-175
32482891-6	2020	Using site-directed mutagenesis, we determined that glycosylation of Asn-471 and Asn-1030 is necessary for ACLP secretion and identified a specific N-terminal proteolytic ACLP fragment.	Asparagine	81-84	AE binding protein 1	Homo sapiens	107-111
32451662-3	2020	MAGT1 is now confirmed as a non-catalytic subunit of the oligosaccharyltransferase complex and facilitates Asparagine (N)-linked glycosylation of specific substrates, making XMEN a congenital disorder of glycosylation manifesting as a combined immune deficiency.	Asparagine	107-117	magnesium transporter 1	Homo sapiens	0-5
32298759-2	2020	GLUT1 modification by N-linked glycosylation at a single asparagine residue (N45) appears to play multiple roles in the trafficking, stability and transport activity of this protein.	Asparagine	57-67	solute carrier family 2 member 1	Homo sapiens	0-5
32451662-3	2020	MAGT1 is now confirmed as a non-catalytic subunit of the oligosaccharyltransferase complex and facilitates Asparagine (N)-linked glycosylation of specific substrates, making XMEN a congenital disorder of glycosylation manifesting as a combined immune deficiency.	Asparagine	107-117	magnesium transporter 1	Homo sapiens	174-178
32452419-4	2020	However, when Asp185 in nsp4 was replaced by a similar structure amino acid Asparagine 185 (Asn185), nsp4 stayed but with a decreased protease activity.	Asparagine	76-86	serine protease 57	Homo sapiens	24-28
32446448-6	2020	A single amino acid residue difference in oligopeptides can make the reaction rate constants differ by over 60% (e.g. 3.01 x 104 (mol/L)-1sec-1 for DDDWNDD and 1.85 x 104 (mol/L)-1sec-1 for DDDWDDD at pH 7.0 (D: aspartic acid, W: tryptophan, N: asparagine)).	Asparagine	245-255	secretory blood group 1, pseudogene	Homo sapiens	138-143
32452419-4	2020	However, when Asp185 in nsp4 was replaced by a similar structure amino acid Asparagine 185 (Asn185), nsp4 stayed but with a decreased protease activity.	Asparagine	76-86	serine protease 57	Homo sapiens	101-105
32144209-9	2020	We found that Asn (polar) and Asp (charged) activate PKM2 and that Val (hydrophobic) inhibits it.	Asparagine	14-17	pyruvate kinase M1/2	Homo sapiens	53-57
32573677-5	2020	Asparagine-linked glycan-dependent folding and deacylation by PGAP1 work together to ensure that correctly folded GPI-APs are transported from the ER to the Golgi.	Asparagine	0-10	post-GPI attachment to proteins inositol deacylase 1	Homo sapiens	62-67
32515459-6	2020	These three peptides showed hydrophobic and acidic amino acid residues (Asp and Glu) and/or their amines (Asn and Gln), which could be a common feature among lipid-lowering peptides related to CE and PL enzyme inhibition.	Asparagine	106-109	pancreatic lipase	Homo sapiens	200-202
32168410-4	2020	METHODS: Asparagine-linked carbohydrates were released from human FXIIII-B by PNGase F digestion.	Asparagine	9-19	N-glycanase 1	Homo sapiens	78-84
32612596-7	2020	Furthermore, the ASN (N)-X-Thr (T) motif at HA1 residues 158-160, encoding a glycosylation site as shown by C18 Chip-Q-TOF-MS, predominated worldwide and played a critical role in RBC receptor binding.	Asparagine	17-20	keratin 31	Homo sapiens	44-47
32107312-1	2020	Human aspartate/asparagine-beta-hydroxylase (AspH) is a 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes the post-translational hydroxylation of Asp and Asn residues in epidermal growth factor-like domains (EGFDs).	Asparagine	160-163	aspartate beta-hydroxylase	Homo sapiens	45-49
32356124-13	2020	Online protein structure predictions revealed that BRCA1 (3326A>T) mutations mutated AGA at this site to TGA resulting in a translated Arg (arginine) mutation as a stop codon, while BRCA2 (1342A>C) mutated AAT at this site to CAT resulting in a translated Asn mutation to His.	Asparagine	256-259	BRCA1 DNA repair associated	Homo sapiens	51-56
32457455-1	2020	The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-beta-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like domains (EGFDs).	Asparagine	125-128	aspartate beta-hydroxylase	Homo sapiens	84-88
32233400-12	2020	Considering the glycosylation on TLR3, a new direction for TLR3 modulator design was pointed out to target asparagine glycosylation.	Asparagine	107-117	toll-like receptor 3	Mus musculus	33-37
32233400-12	2020	Considering the glycosylation on TLR3, a new direction for TLR3 modulator design was pointed out to target asparagine glycosylation.	Asparagine	107-117	toll-like receptor 3	Mus musculus	59-63
32483464-0	2020	MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway.	Asparagine	52-62	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-5
32483464-0	2020	MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway.	Asparagine	52-62	CD82 molecule	Homo sapiens	44-48
32483464-11	2020	Conclusions: Our work implicates a pathway for ovarian cancers metastasis regulation via MGAT3 mediated glycosylation of tetraspanin CD82 at asparagine 157.	Asparagine	141-151	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	89-94
32483464-11	2020	Conclusions: Our work implicates a pathway for ovarian cancers metastasis regulation via MGAT3 mediated glycosylation of tetraspanin CD82 at asparagine 157.	Asparagine	141-151	CD82 molecule	Homo sapiens	133-137
32265297-10	2020	Interestingly, in OTUB2, the catalytic residues His-224 and Asn-226 formed a stable hydrogen bond.	Asparagine	60-63	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	18-23
32222585-3	2020	Pioneer studies on FcgammaR N-glycans have unveiled an additional complexity in that the N-glycan linked on the Asn-162 of FcgammaRIIIa was shown to be directly involved in the strong affinity for afucosylated IgG1.	Asparagine	112-115	Fc gamma receptor IIIa	Homo sapiens	123-135
32483417-10	2020	Among these amino acids, asparagine (Asn), phenylalanine (Phe), and histidine (His) promoted CRC cell survival under glucose starvation when JMJD2B was knocked down.	Asparagine	25-35	lysine demethylase 4B	Homo sapiens	141-147
32483417-11	2020	Mechanistically, downregulation of JMJD2B inhibited autophagy in CRC cells through epigenetic regulation of microtubule associated protein 1 light chain 3 beta (LC3B), and subsequently decreased intracellular amino acid (Asn, Phe, His) levels under glucose deprivation, thus suppressing the survival of CRC cells.	Asparagine	221-224	lysine demethylase 4B	Homo sapiens	35-41
32483417-12	2020	Using a nude mouse xenograft model, we verified that inhibiting JMJD2B could decrease the levels of amino acids (Asn, Phe, His).	Asparagine	113-116	lysine (K)-specific demethylase 4B	Mus musculus	64-70
32144209-10	2020	The results also indicate that both Asn and Asp can restore the activity of Val-inhibited PKM2.	Asparagine	36-39	pyruvate kinase M1/2	Homo sapiens	90-94
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	34-44	tumor protein p53	Homo sapiens	20-23
32273511-0	2020	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.	Asparagine	34-44	tumor protein p53	Homo sapiens	0-3
32272966-10	2020	At amino acid level, the strongest association seen in uncontrolled analysis was with histidine at position 114 in HLA-B (P = 7.24 x 10-241), but conditional analyses suggest that the primary amino acid associations are with lysine at position 70 and asparagine at position 97.	Asparagine	251-261	major histocompatibility complex, class I, B	Homo sapiens	115-120
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	34-44	serine/threonine kinase 11	Homo sapiens	158-162
32273511-0	2020	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.	Asparagine	34-44	serine/threonine kinase 11	Homo sapiens	66-70
32273511-1	2020	Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine.	Asparagine	84-94	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	34-44	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-167
32273511-1	2020	Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine.	Asparagine	84-94	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
32273511-3	2020	Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro.	Asparagine	36-46	tumor protein p53	Homo sapiens	21-24
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	128-138	tumor protein p53	Homo sapiens	20-23
32273511-3	2020	Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro.	Asparagine	36-46	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	103-107
32273511-3	2020	Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro.	Asparagine	132-142	tumor protein p53	Homo sapiens	21-24
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	128-138	serine/threonine kinase 11	Homo sapiens	158-162
32273511-4	2020	Moreover, the removal of asparagine from culture medium or the inhibition of ASNS impairs cell proliferation and induces p53/p21-dependent senescence and cell cycle arrest.	Asparagine	25-35	tumor protein p53	Homo sapiens	121-124
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Asparagine	128-138	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-167
32273511-4	2020	Moreover, the removal of asparagine from culture medium or the inhibition of ASNS impairs cell proliferation and induces p53/p21-dependent senescence and cell cycle arrest.	Asparagine	25-35	H3 histone pseudogene 16	Homo sapiens	125-128
32273511-7	2020	Our findings highlight a role for LKB1 in sensing asparagine and aspartate and connect asparagine metabolism to the cellular signalling transduction network that modulates cell survival.	Asparagine	50-60	serine/threonine kinase 11	Homo sapiens	34-38
32273511-7	2020	Our findings highlight a role for LKB1 in sensing asparagine and aspartate and connect asparagine metabolism to the cellular signalling transduction network that modulates cell survival.	Asparagine	87-97	serine/threonine kinase 11	Homo sapiens	34-38
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Asparagine	17-27	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	51-55
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Asparagine	17-27	tumor protein p53	Homo sapiens	65-68
32019866-0	2020	Glutamine and asparagine activate mTORC1 independently of Rag GTPases.	Asparagine	14-24	CREB regulated transcription coactivator 1	Mus musculus	34-40
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Asparagine	17-27	serine/threonine kinase 11	Homo sapiens	105-109
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Asparagine	17-27	serine/threonine kinase 11	Homo sapiens	136-140
32268116-0	2020	ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.	Asparagine	16-26	zinc finger and BTB domain containing 1	Homo sapiens	0-5
32268116-4	2020	While ATF4 is universally required under amino acid starvation, our screens yielded a transcription factor, Zinc Finger and BTB domain-containing protein 1 (ZBTB1), as uniquely essential under asparagine deprivation.	Asparagine	193-203	zinc finger and BTB domain containing 1	Homo sapiens	108-155
32268116-4	2020	While ATF4 is universally required under amino acid starvation, our screens yielded a transcription factor, Zinc Finger and BTB domain-containing protein 1 (ZBTB1), as uniquely essential under asparagine deprivation.	Asparagine	193-203	zinc finger and BTB domain containing 1	Homo sapiens	157-162
32268116-5	2020	ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the enzyme responsible for asparagine synthesis.	Asparagine	46-56	zinc finger and BTB domain containing 1	Homo sapiens	0-5
32268116-5	2020	ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the enzyme responsible for asparagine synthesis.	Asparagine	86-96	zinc finger and BTB domain containing 1	Homo sapiens	0-5
32268116-5	2020	ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the enzyme responsible for asparagine synthesis.	Asparagine	86-96	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	109-113
32268116-7	2020	Finally, loss of ZBTB1 sensitizes therapy-resistant T cell leukemia cells to L-asparaginase, a chemotherapeutic that depletes serum asparagine.	Asparagine	132-142	zinc finger and BTB domain containing 1	Homo sapiens	17-22
32268116-7	2020	Finally, loss of ZBTB1 sensitizes therapy-resistant T cell leukemia cells to L-asparaginase, a chemotherapeutic that depletes serum asparagine.	Asparagine	132-142	asparaginase and isoaspartyl peptidase 1	Homo sapiens	77-91
32234060-3	2020	An asparagine-linked glycan on the "glycan loop" (GL) of the ZIKV envelope protein protects the functionally important "fusion loop" on the opposite E subunit in the dimer, and EDE antibodies have been shown to bind to both of these loops.	Asparagine	3-13	endogenous retrovirus group K member 6, envelope	Homo sapiens	66-82
32226879-3	2020	Understanding the structure of Ure2 fibrils is important for understanding the propagation not only of the [URE3] prion but also of other yeast prions whose prion domains share similar features, such as the enrichment of asparagine and glutamine residues.	Asparagine	221-231	glutathione peroxidase	Saccharomyces cerevisiae S288C	31-35
32226879-11	2020	Overall, the structure of Ure2 fibrils appears to involve a balance of stabilizing interactions, such as asparagine ladders, and destabilizing interactions, such as stacking of charged residues.	Asparagine	105-115	glutathione peroxidase	Saccharomyces cerevisiae S288C	26-30
31400201-0	2020	Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma.	Asparagine	8-18	tumor protein p53	Homo sapiens	56-59
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Asparagine	166-169	agouti related neuropeptide	Mus musculus	46-50
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Asparagine	166-169	melanocortin 3 receptor	Mus musculus	55-59
32157140-6	2020	Using a heterologous expression system, we show that N-glycosylation occurs at four conserved asparagine residues in the N-terminal region of Gpr176.	Asparagine	94-104	G protein-coupled receptor 176	Mus musculus	142-148
32019866-6	2020	Like glutamine, asparagine signals to mTORC1 through Arf1 in the absence of the Rag GTPases.	Asparagine	16-26	CREB regulated transcription coactivator 1	Mus musculus	38-44
32019866-6	2020	Like glutamine, asparagine signals to mTORC1 through Arf1 in the absence of the Rag GTPases.	Asparagine	16-26	ADP ribosylation factor 1	Homo sapiens	53-57
31882538-9	2020	Guided by previous structural studies, we hypothesized that Asn-169, a conserved residue in the AAG active-site pocket, contributes to discrimination against epsilonG.	Asparagine	60-63	N-methylpurine DNA glycosylase	Homo sapiens	96-99
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	9-12	follicle stimulating hormone receptor	Homo sapiens	4-8
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	57-60	follicle stimulating hormone receptor	Homo sapiens	4-8
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	57-60	follicle stimulating hormone receptor	Homo sapiens	4-8
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	57-60	follicle stimulating hormone receptor	Homo sapiens	4-8
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	57-60	follicle stimulating hormone receptor	Homo sapiens	4-8
32724273-5	2020	The FSHR Asn680Ser genotype frequencies were as follows: Asn/Ser 42%, Ser/Ser 33.9% and Asn/Asn 24.1% in the control group, and Asn/Ser 56.1%, Ser/Ser 22.8% and Asn/Asn 21.1% in the whole group of infertile men (chi2-test: P=0.08).	Asparagine	57-60	follicle stimulating hormone receptor	Homo sapiens	4-8
32566918-6	2020	Mutating D8 to an asparagine led to the greatest improvement in Pn3a potency at NaV1.7 (20-fold), while maintaining >100-fold selectivity over the major off-targets NaV1.4, NaV1.5, and NaV1.6.	Asparagine	18-28	sodium voltage-gated channel alpha subunit 9	Homo sapiens	80-86
32566918-6	2020	Mutating D8 to an asparagine led to the greatest improvement in Pn3a potency at NaV1.7 (20-fold), while maintaining >100-fold selectivity over the major off-targets NaV1.4, NaV1.5, and NaV1.6.	Asparagine	18-28	sodium voltage-gated channel alpha subunit 4	Homo sapiens	165-171
32566918-6	2020	Mutating D8 to an asparagine led to the greatest improvement in Pn3a potency at NaV1.7 (20-fold), while maintaining >100-fold selectivity over the major off-targets NaV1.4, NaV1.5, and NaV1.6.	Asparagine	18-28	sodium voltage-gated channel alpha subunit 5	Homo sapiens	173-179
32566918-6	2020	Mutating D8 to an asparagine led to the greatest improvement in Pn3a potency at NaV1.7 (20-fold), while maintaining >100-fold selectivity over the major off-targets NaV1.4, NaV1.5, and NaV1.6.	Asparagine	18-28	sodium voltage-gated channel alpha subunit 8	Homo sapiens	185-191
32180807-1	2020	L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients.	Asparagine	0-12	asparaginase and isoaspartyl peptidase 1	Homo sapiens	48-62
32180807-1	2020	L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients.	Asparagine	0-12	asparaginase and isoaspartyl peptidase 1	Homo sapiens	64-70
32180807-1	2020	L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients.	Asparagine	14-17	asparaginase and isoaspartyl peptidase 1	Homo sapiens	48-62
32180807-1	2020	L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients.	Asparagine	14-17	asparaginase and isoaspartyl peptidase 1	Homo sapiens	64-70
32180807-2	2020	The ASN level is found to be closely associated with the effectiveness of ASNase treatment.	Asparagine	4-7	asparaginase and isoaspartyl peptidase 1	Homo sapiens	74-80
32180807-8	2020	Collectively, the research may shed new light on an alternative rapid, simple, and convenient quantitative method for determination of serum ASN in ALL patients treated with ASNase.	Asparagine	141-144	asparaginase and isoaspartyl peptidase 1	Homo sapiens	174-180
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Asparagine	172-182	monoamine oxidase A	Homo sapiens	112-131
31888963-3	2020	Furthermore, post-translational modification impacts antibody binding affinity, most notably the composition of the asparagine(N)-linked glycan at N162 of CD16a.	Asparagine	116-126	Fc gamma receptor IIIa	Homo sapiens	155-160
31793911-4	2020	Activation of asparagine endopeptidase-cleaved Tau aggregation in vitro and in intact cells was triggered by 3,4-dihydroxyphenylglycolaldehyde, resulting in LC neurotoxicity and propagation of pathology to the forebrain.	Asparagine	14-24	microtubule associated protein tau	Homo sapiens	47-50
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Asparagine	172-182	microtubule associated protein tau	Homo sapiens	210-213
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Asparagine	172-182	microtubule associated protein tau	Homo sapiens	327-330
31421261-2	2020	ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, asparagine synthetase (ASNS), replenishes asparagine.	Asparagine	89-99	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	112-116
30823860-1	2020	Pegaspargase, a long acting formulation of L-asparaginase, is an asparagine specific enzyme that selectively kills leukemic cells by depleting plasma asparagine.	Asparagine	65-75	asparaginase and isoaspartyl peptidase 1	Homo sapiens	43-57
30823860-1	2020	Pegaspargase, a long acting formulation of L-asparaginase, is an asparagine specific enzyme that selectively kills leukemic cells by depleting plasma asparagine.	Asparagine	150-160	asparaginase and isoaspartyl peptidase 1	Homo sapiens	43-57
33287663-0	2020	Correlation of L-asp Activity, Anti-L-asp Antibody, Asn and Gln With Adverse Events Especially Anaphylaxis Risks in PEG-asp-Contained Regime Treated Pediatric ALL Patients.	Asparagine	52-55	progestagen associated endometrial protein	Homo sapiens	116-119
31682474-4	2019	NC1 peptide was found to exert its biologic effects through an activation of small GTPase cell division control protein 42 homolog (Cdc42) because cooverexpression of the dominant negative mutant of Cdc42 [namely, Cdc42-T17N (via a single mutation of amino acid residue 17 from the N terminus from Thr to Asn by site-directed mutagenesis, making it constitutively inactive)] and NC1 peptide was able to block the NC1 peptide-induced Sertoli cell tight junction-permeability barrier disruption.	Asparagine	305-308	cell division cycle 42	Rattus norvegicus	90-130
32725167-3	2019	Purified MHC-I/TAPBPR complexes can be prepared for multiple human allotypes, and exhibit complex glycan modifications at the conserved Asn 86 residue.	Asparagine	136-139	TAP binding protein like	Homo sapiens	15-21
31659118-0	2019	Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.	Asparagine	30-40	activating transcription factor 4	Homo sapiens	73-77
31659118-2	2019	For example, during amino acid limitations, ATF4 in the amino acid response induces expression of asparagine synthetase (ASNS), which provides for asparagine biosynthesis.	Asparagine	98-108	activating transcription factor 4	Homo sapiens	44-48
31659118-2	2019	For example, during amino acid limitations, ATF4 in the amino acid response induces expression of asparagine synthetase (ASNS), which provides for asparagine biosynthesis.	Asparagine	98-108	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	121-125
31659118-6	2019	Here we show that DNA hypermethylation at the ASNS promoter prevents its transcriptional expression following asparagine depletion.	Asparagine	110-120	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	46-50
31659118-8	2019	We conclude that chromatin accessibility is critical for ATF4 activity at the ASNS promoter, which can switch ALL cells from an ATF4-dependent adaptive response to ATF4-independent apoptosis during asparagine depletion.	Asparagine	198-208	activating transcription factor 4	Homo sapiens	57-61
31659118-8	2019	We conclude that chromatin accessibility is critical for ATF4 activity at the ASNS promoter, which can switch ALL cells from an ATF4-dependent adaptive response to ATF4-independent apoptosis during asparagine depletion.	Asparagine	198-208	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	78-82
31682474-4	2019	NC1 peptide was found to exert its biologic effects through an activation of small GTPase cell division control protein 42 homolog (Cdc42) because cooverexpression of the dominant negative mutant of Cdc42 [namely, Cdc42-T17N (via a single mutation of amino acid residue 17 from the N terminus from Thr to Asn by site-directed mutagenesis, making it constitutively inactive)] and NC1 peptide was able to block the NC1 peptide-induced Sertoli cell tight junction-permeability barrier disruption.	Asparagine	305-308	cell division cycle 42	Rattus norvegicus	132-137
31523835-7	2019	Lastly, in vivo experiments indicated that SLC1A3 expression promoted tumor development and metastasis while negating the suppressive effects of ASNase by fueling aspartate, glutamate, and glutamine metabolisms despite of asparagine shortage.	Asparagine	222-232	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	43-49
31783892-3	2019	Considering that the codon of Asparagine is aac or aat, we wondered if the adenine base editor (ABE), which induces a t to g c conversion at specific site, could be used to reduce PD-1 suppression by changing the glycosylated residue in CAR-T cells.	Asparagine	30-40	CXADR Ig-like cell adhesion molecule	Sus scrofa	237-240
30993718-4	2019	The l-asparaginase anticancerous application approach has made incredible breakthrough in the field of modern oncology through depletion of plasma l-asparagine to inhibit the cancer cells growth; particularly among children.	Asparagine	147-159	asparaginase and isoaspartyl peptidase 1	Homo sapiens	4-18
31628314-3	2019	We report that beta2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N-terminus, while being independent of surrounding amino-acid residues.	Asparagine	47-57	adenosine A2a receptor	Homo sapiens	15-22
33437604-3	2020	In this study, we found a novel sequence variation G26A (GAT to AAT) in 5" half of TGIF1 gene (p. aspartic acid >asparagine) at a frequency of 62% (148/240, P <= 0.0001).	Asparagine	113-123	TGFB induced factor homeobox 1	Homo sapiens	83-88
31693361-10	2019	A structure of N140A-TDG bound to cadC DNA provides the first high-resolution insight into how enzyme-substrate interactions, including water molecules, are impacted by depleting the conserved Asn, informing its role in binding and addition of the nucleophilic water molecule.	Asparagine	193-196	thymine DNA glycosylase	Homo sapiens	21-24
31520600-7	2019	Charge restoration via substitution of an internal aspartate by asparagine improved potency, achieving low nM apoptotic response in VEGF-activated EC.	Asparagine	64-74	vascular endothelial growth factor A	Mus musculus	132-136
31471319-8	2019	ZNT1 is N-glycosylated on Asn 299 in the extracellular loop between transmembrane domains V and VI, and this appears to be involved in the regulation of ZNT1 stability, as nonglycosylated ZNT1 is more stable.	Asparagine	26-29	solute carrier family 30 member 1	Homo sapiens	0-4
31594813-5	2019	Focused characterization of one of the hits, asparagine synthetase (ASNS), demonstrated a strict requirement for asparagine for HCMV replication which leads to an early block in virus replication before the onset of DNA amplification.	Asparagine	45-55	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	68-72
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Asparagine	199-202	amine oxidase copper containing 2	Homo sapiens	177-181
31199181-2	2019	We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-determining region 1, and risk mitigation through protein engineering.	Asparagine	50-53	CD52 molecule	Homo sapiens	86-90
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Asparagine	199-202	amine oxidase copper containing 4, pseudogene	Homo sapiens	206-210
31342597-7	2019	We found that the mutation that improved stability the most (~7 C) was one which changed an amino acid in CDR1 from an asparagine to an aspartic acid.	Asparagine	119-129	cerebellar degeneration related protein 1	Homo sapiens	106-110
31296657-5	2019	To overcome this limitation, here we investigated a CysRS from the selenium accumulator plant Astragalus bisulcatus that is reported to reject Sec in vitro Sequence analysis revealed a rare His   Asn variation adjacent to the CysRS catalytic pocket.	Asparagine	196-199	cysteinyl-tRNA synthetase 1	Homo sapiens	52-57
31308178-4	2019	Here, using glycoside hydrolase and kinase assays and immunoprecipitation and MS-based analyses, we demonstrate that N-linked glycans at the Asn-247 site in VEGFR2 hinder VEGF ligand-mediated receptor activation and signaling in endothelial cells.	Asparagine	141-144	kinase insert domain receptor	Homo sapiens	157-163
31308178-4	2019	Here, using glycoside hydrolase and kinase assays and immunoprecipitation and MS-based analyses, we demonstrate that N-linked glycans at the Asn-247 site in VEGFR2 hinder VEGF ligand-mediated receptor activation and signaling in endothelial cells.	Asparagine	141-144	vascular endothelial growth factor A	Homo sapiens	157-161
31308178-5	2019	We provide evidence that cell surface-associated VEGFR2 displays sialylated N-glycans at Asn-247 and, in contrast, that the nearby sites Asn-145 and Asn-160 contain lower levels of sialylated N-glycans and higher levels of high-mannose N-glycans, respectively.	Asparagine	89-92	kinase insert domain receptor	Homo sapiens	49-55
31308178-7	2019	We propose that N-glycosylation, specifically the capping of N-glycans at Asn-247 by sialic acid, tunes ligand-dependent activation and signaling of VEGFR2 in endothelial cells.	Asparagine	74-77	kinase insert domain receptor	Homo sapiens	149-155
31507595-1	2019	Human CD52 is a small glycopeptide (12 amino acid residues) with one N-linked glycosylation site at asparagine 3 (Asn3) and several potential O-glycosylation serine/threonine sites.	Asparagine	100-110	CD52 molecule	Homo sapiens	6-10
31209181-2	2019	Here, we attempted to disentangle the relationship between asparagine metabolism, glutamine metabolism, and downstream pathways that modulate cell viability by testing the hypothesis that ASNase anticancer activity is based on asparagine depletion rather than glutamine depletion per se.	Asparagine	227-237	asparaginase and isoaspartyl peptidase 1	Homo sapiens	188-194
31296657-7	2019	Although the CysRS variant could still use Sec as a substrate in vitro, we observed a reduction in the frequency of Sec misincorporation at Cys codons in vivo We surmise that the His   Asn variation can be introduced into any CysRS to provide a fitness advantage for strains burdened by Sec misincorporation and selenium toxicity.	Asparagine	185-188	cysteinyl-tRNA synthetase 1	Homo sapiens	13-18
31296657-7	2019	Although the CysRS variant could still use Sec as a substrate in vitro, we observed a reduction in the frequency of Sec misincorporation at Cys codons in vivo We surmise that the His   Asn variation can be introduced into any CysRS to provide a fitness advantage for strains burdened by Sec misincorporation and selenium toxicity.	Asparagine	185-188	cysteinyl-tRNA synthetase 1	Homo sapiens	226-231
31406120-4	2019	Using a calcium-imaging assay and two-voltage clamp recording, we found that one of the honey bee"s gustatory receptors, AmGr10, functions as a broadly tuned amino acid receptor responding to glutamate, aspartate, asparagine, arginine, lysine, and glutamine, but not to other sweet or bitter compounds.	Asparagine	214-224	gustatory receptor 10	Apis mellifera	121-127
31070815-4	2019	However, these simulations contradict another popular hypothesis that supposes that the negative charge on the intermediate is stabilized by a highly conserved asparagine (Asn79 in Ubc13).	Asparagine	160-170	ubiquitin conjugating enzyme E2 N	Homo sapiens	181-186
31347358-0	2019	A Second Backbone: The Contribution of a Buried Asparagine Ladder to the Global and Local Stability of a Leucine-Rich Repeat Protein.	Asparagine	48-58	nyctalopin	Homo sapiens	105-132
31347358-4	2019	Here we test the contribution of a minimal asparagine ladder from the leucine-rich repeat protein pp32 to stability and investigate lattice rigidity and hydrogen bond character using solution nuclear magnetic resonance (NMR) spectroscopy.	Asparagine	43-53	nyctalopin	Homo sapiens	70-97
31347358-5	2019	Point substitutions of the two ladder asparagines of pp32 are strongly destabilizing and decrease the cooperativity of unfolding.	Asparagine	38-49	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	53-57
30205752-7	2019	We further found that Lys, Glu, Gln, Asn, and Arg residues shared the major contribution toward the intermolecular interactions in XPA homo-dimers.	Asparagine	37-40	XPA, DNA damage recognition and repair factor	Homo sapiens	131-134
31370780-12	2019	Genes encoding regulatory protein kinases, SnRK1 and GCN2, both implicated in regulating asparagine synthetase gene expression, also responded to sulphur deficiency.	Asparagine	89-99	snRK1	Triticum aestivum	43-48
31370780-12	2019	Genes encoding regulatory protein kinases, SnRK1 and GCN2, both implicated in regulating asparagine synthetase gene expression, also responded to sulphur deficiency.	Asparagine	89-99	eIF-2-alpha kinase GCN2	Triticum aestivum	53-57
31311714-8	2019	PNG catalyzes the cleavage of the proximal N-acetylglucosamine residue of an N-glycan from the asparagine residue of a protein, a step in the degradation of misfolded glycoproteins.	Asparagine	95-105	N-glycanase 1	Homo sapiens	0-3
31277353-4	2019	By mutational analysis, we found that Asn-145 plays critical roles for Env-mediated cell-cell fusion and HIV-1 entry.	Asparagine	38-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	71-74
31523200-3	2019	In the present study, we have established a knock in mouse model containing an Asn-to-Ser substitution at p53 amino acid 236 by homologous recombination (p53N236S).	Asparagine	79-82	transformation related protein 53, pseudogene	Mus musculus	106-109
31333491-5	2019	Kinetic analyses in the S-(+)-1,2,3,4-tetrahydro-1-naphthol (s-tetralol) catalyzed by AKR1C1 in the presence of the inhibitors suggest that liquiritin is a competitive inhibitor by targeting the residues Ala-27, Val-29, Ala-25, and Asn-56 of AKR1C1.	Asparagine	232-235	aldo-keto reductase family 1 member C1	Homo sapiens	86-92
31277353-3	2019	In this study, we focused on characterizing the structural and functional properties of a single Asn-145 residue, which locates at the middle CHR site of gp41 and is extremely conserved among all the HIV-1, HIV-2, and simian immunodeficiency virus (SIV) isolates.	Asparagine	97-100	chromate resistance; sulfate transport	Homo sapiens	142-145
31006065-0	2019	Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody.	Asparagine	57-67	microtubule associated protein tau	Homo sapiens	37-40
31006065-0	2019	Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody.	Asparagine	57-67	microtubule associated protein tau	Homo sapiens	115-118
30829738-1	2019	OBJECTIVE: To study if the follicle-stimulating hormone receptor (FSHR) variant asparagine/serine in amino acid 680 (N680S) can predict hypersensitivity to gonadotropins in women undergoing assisted reproduction.	Asparagine	80-90	follicle stimulating hormone receptor	Homo sapiens	27-64
30978155-1	2019	PURPOSE: Asparaginase is an essential drug in childhood acute lymphoblastic leukemia (ALL) therapy and is frequently given for months to obtain continuous asparagine depletion.	Asparagine	155-165	asparaginase	Homo sapiens	9-21
31026515-2	2019	Sequencing of the mitochondrial genome (mtDNA) identified a transition variant in the tRNA asparagine gene (MT-TN) (m.5728T>C) at in 41% of mtDNA molecules in muscle tissue.	Asparagine	91-101	mitochondrially encoded tRNA asparagine	Homo sapiens	108-113
30829738-1	2019	OBJECTIVE: To study if the follicle-stimulating hormone receptor (FSHR) variant asparagine/serine in amino acid 680 (N680S) can predict hypersensitivity to gonadotropins in women undergoing assisted reproduction.	Asparagine	80-90	follicle stimulating hormone receptor	Homo sapiens	66-70
30962282-8	2019	In cone Pgamma, Asn-13 and Gln-14 significantly enhanced Gtalpha*-GTPgammaS activation of cone Pgamma truncation variants.	Asparagine	16-19	integrin subunit alpha 2b	Homo sapiens	57-64
31316816-6	2019	Other interesting features of EPDR1 include two asparagine residues with glycosylation and a Ca2+-binding site.	Asparagine	48-58	ependymin related 1	Homo sapiens	30-35
30921515-6	2019	We next solved cryo-EM structures of two Sso-KARI complexes, with NADH+inhibitor and NADPH+inhibitor at pH 7.5, which indicate that the bispecificity can be attributed to a unique asparagine at the cofactor binding loop.	Asparagine	180-190	hypothetical protein	Saccharolobus solfataricus	45-49
31100039-6	2019	This mutation leads to an asparagine to lysine substitution ( p.Asn84Lys ) located in the extracellular domain of IL2RG, which is predicted to be pathogenic.	Asparagine	26-36	interleukin 2 receptor subunit gamma	Homo sapiens	114-119
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Asparagine	132-142	N-glycanase 1	Homo sapiens	23-28
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Asparagine	132-142	N-glycanase 1	Homo sapiens	29-34
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Asparagine	132-142	N-glycanase 1	Homo sapiens	35-54
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Asparagine	132-142	POU class 2 homeobox 3	Homo sapiens	77-83
30975901-2	2019	Previous studies have suggested that residue Asn-21 plays a critical role in the in vitro self-assembly of IAPP.	Asparagine	45-48	islet amyloid polypeptide	Homo sapiens	107-111
30975901-5	2019	In contrast, Asn-21 substitution with the conformationally constrained and turn-inducing residue Pro accelerated IAPP self-assembly.	Asparagine	13-16	islet amyloid polypeptide	Homo sapiens	113-117
31123592-0	2019	Clinical outcomes of two patients with a novel pathogenic variant in ASNS: response to asparagine supplementation and review of the literature.	Asparagine	87-97	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	69-73
31123592-8	2019	These results support our hypothesis that asparagine supplementation should be further investigated as a treatment option for ASNSD.	Asparagine	42-52	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	126-131
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Asparagine	237-240	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-56
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Asparagine	237-240	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	58-62
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Asparagine	237-240	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	104-138
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Asparagine	237-240	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	140-144
30920200-6	2019	The apparent Michaelis-Menten constants ( Km and Vmax) of the l-ASNase enzyme reactor at different pH values were determined by a chiral ligand-exchange capillary electrophoresis method with l-asparagine as the substrate.	Asparagine	191-203	asparaginase and isoaspartyl peptidase 1	Homo sapiens	62-70
30991026-1	2019	Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem.	Asparagine	65-75	asparaginase	Homo sapiens	14-26
30991026-4	2019	Sensitization to asparaginase was mediated by Wnt-dependent stabilization of proteins (Wnt/STOP), which inhibits glycogen synthase kinase 3 (GSK3)-dependent protein ubiquitination and proteasomal degradation, a catabolic source of asparagine.	Asparagine	231-241	asparaginase	Homo sapiens	17-29
30760526-0	2019	Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation.	Asparagine	0-10	ATPase phospholipid transporting 8A2	Homo sapiens	54-60
30760526-0	2019	Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation.	Asparagine	0-10	ATPase phospholipid transporting 8A2	Homo sapiens	116-122
30808712-4	2019	Here, using site-directed mutagenesis, we show that Asn-26 in the motif is crucial for RAT of TM4SF20, as it cannot be replaced even by Gln.	Asparagine	52-55	transmembrane 4 L six family member 20	Rattus norvegicus	94-101
30677534-6	2019	Computational analysis showed that these mutations may lead to remarkable changes in the conformational structure and asparagine (N)-linked glycosylation sites of S1-NTD, which may be associated with the altered pathogenicity of these variant PEDV strains.	Asparagine	118-128	proteasome 26S subunit, non-ATPase 1	Homo sapiens	163-169
31024344-9	2019	In immunoprecipitations, however, the homodimerization of MdmX could be observed only when the asparagine residue was replaced with cysteine in both RINGs.	Asparagine	95-105	MDM4 regulator of p53	Homo sapiens	58-62
31024344-10	2019	This result suggested that heterocomplexes consisting of one mutated MdmX RING with cysteine and one wild-type MdmX RING with asparagine might be less stable, despite being readily detectable in the cell-based assay.	Asparagine	126-136	MDM4 regulator of p53	Homo sapiens	111-115
30949841-0	2019	Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in E. coli.	Asparagine	45-55	insulin	Homo sapiens	80-87
30949841-3	2019	RESULTS: The misincorporated lysine (Lys) at asparagine (Asn) position A21 was detected in recombinant human insulin and its analogs.	Asparagine	45-55	insulin	Homo sapiens	109-116
30949841-3	2019	RESULTS: The misincorporated lysine (Lys) at asparagine (Asn) position A21 was detected in recombinant human insulin and its analogs.	Asparagine	57-60	insulin	Homo sapiens	109-116
30949841-4	2019	CONCLUSIONS: Although there are three asparagine residues in the insulin derivative, the misincorporation of lysine occurred only at position A21.	Asparagine	38-48	insulin	Homo sapiens	65-72
30156702-4	2019	MS revealed that AtGAL1 was bisphosphorylated at Tyr38 and Thr39 and glycosylated at four conserved Asn residues.	Asparagine	100-103	Mevalonate/galactokinase family protein	Arabidopsis thaliana	17-23
30899001-3	2019	We report a highly selective transformation of asparagine 373, located in an antigenic loop adjoining the HBGA binding site, into an iso-aspartate residue.	Asparagine	47-57	hemoglobin subunit gamma 1	Homo sapiens	106-110
31049124-12	2019	In silico docking studies confirmed interaction between 2-AP and the adenosine A2a receptor through hydrogen bonds with the critical asparagine 253 residues present in the active site.	Asparagine	133-143	adenosine A2a receptor	Homo sapiens	69-91
33654988-2	2019	A membrane-bound enzyme, oligosaccharyltransferase, catalyzes the transfer of an oligosaccharide chain from a sugar donor (lipid-linked oligosaccharide, LLO) to an asparagine residue in the consensus sequence, Asn-X-Ser/Thr (X   Pro), in proteins.	Asparagine	164-174	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	25-50
30858360-0	2019	SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.	Asparagine	81-91	SRY-box transcription factor 12	Homo sapiens	0-5
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	SRY-box transcription factor 12	Homo sapiens	17-22
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	glutaminase	Homo sapiens	75-86
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	glutaminase	Homo sapiens	88-91
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	glutamic-oxaloacetic transaminase 2	Homo sapiens	94-129
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	glutamic-oxaloacetic transaminase 2	Homo sapiens	131-135
30858360-5	2019	Mechanistically, SOX12 facilitated asparagine synthesis by transactivating glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS).	Asparagine	35-45	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	142-163
30617148-4	2019	Here, we found that substitution of Asp at position 172 in the linker between the LR4 and LR5 of full-length LDLR with Asn (D172N) reduced PCSK9 binding at pH 7.4 (mimic cell surface), but not at pH 6.0 (mimic endosomal environment).	Asparagine	119-122	low density lipoprotein receptor	Homo sapiens	109-113
30617148-4	2019	Here, we found that substitution of Asp at position 172 in the linker between the LR4 and LR5 of full-length LDLR with Asn (D172N) reduced PCSK9 binding at pH 7.4 (mimic cell surface), but not at pH 6.0 (mimic endosomal environment).	Asparagine	119-122	proprotein convertase subtilisin/kexin type 9	Homo sapiens	139-144
30617148-5	2019	On the other hand, mutation of Asp at position 203 in the LR5 of full-length LDLR to Asn (D203N) significantly reduced PCSK9 binding at both pH 7.4 and pH 6.0.	Asparagine	85-88	low density lipoprotein receptor	Homo sapiens	77-81
30617148-5	2019	On the other hand, mutation of Asp at position 203 in the LR5 of full-length LDLR to Asn (D203N) significantly reduced PCSK9 binding at both pH 7.4 and pH 6.0.	Asparagine	85-88	proprotein convertase subtilisin/kexin type 9	Homo sapiens	119-124
30600443-0	2019	Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel.	Asparagine	0-10	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	80-86
30760632-0	2019	Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity.	Asparagine	76-86	G protein-coupled estrogen receptor 1	Homo sapiens	6-35
30634463-2	2019	ASNase"s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are converted to aspartic acid (Asp) and glutamic acid (Glu), respectively, in the blood.	Asparagine	69-79	asparaginase like 1	Mus musculus	0-6
30633504-5	2019	As a glutamine residue is not a substrate for cellular oligosaccharyltransferase, we used strategic asparagine-to-glutamine substitutions to produce the three diglycosylated and three monoglycosylated forms of RNase 1.	Asparagine	100-110	ribonuclease A family member 1, pancreatic	Homo sapiens	210-217
30566828-4	2019	Here, we show that three conserved asparagine residues (Asn-39, Asn-287, and Asn-297) play important roles in modulating CTRP12 cleavage, secretion, and stability.	Asparagine	35-45	C1q and TNF related 12	Homo sapiens	121-127
30566828-4	2019	Here, we show that three conserved asparagine residues (Asn-39, Asn-287, and Asn-297) play important roles in modulating CTRP12 cleavage, secretion, and stability.	Asparagine	56-59	C1q and TNF related 12	Homo sapiens	121-127
30566828-4	2019	Here, we show that three conserved asparagine residues (Asn-39, Asn-287, and Asn-297) play important roles in modulating CTRP12 cleavage, secretion, and stability.	Asparagine	64-67	C1q and TNF related 12	Homo sapiens	121-127
30566828-4	2019	Here, we show that three conserved asparagine residues (Asn-39, Asn-287, and Asn-297) play important roles in modulating CTRP12 cleavage, secretion, and stability.	Asparagine	64-67	C1q and TNF related 12	Homo sapiens	121-127
30566828-10	2019	Both Asn-39 and Asn-297 contributed independently to CTRP12 cleavage: maximum cleavage was observed in the double mutant.	Asparagine	5-8	C1q and TNF related 12	Homo sapiens	53-59
30566828-10	2019	Both Asn-39 and Asn-297 contributed independently to CTRP12 cleavage: maximum cleavage was observed in the double mutant.	Asparagine	16-19	C1q and TNF related 12	Homo sapiens	53-59
30788440-5	2019	The HSulf-2 protein sequence was determined by Nano-LC-MS/MS, leading to 63% coverage and indicating at least four N-glycosylation sites at Asn 108, 147, 174 and 217.	Asparagine	140-143	sulfatase 2	Homo sapiens	4-11
30881226-13	2019	Thus, in the advantageous scenario of the asparagine 1405 variant (AC heterozygosity in this study), heightened pulmonary vascular resistance in CHD-PHT is associated with medial hypertrophy of pulmonary arteries where MIF chemokine very likely plays a biological role.	Asparagine	42-52	macrophage migration inhibitory factor	Homo sapiens	219-222
30557817-10	2019	CONCLUSION: Compound ASN 16296138 and BAS 00227397 are potential candidates for experimental validation of biological activity against PI3Kdelta in future drug discovery studies.	Asparagine	21-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	135-144
30639924-7	2019	These observations highlighted the importance of residues 67 (Asn in CA II, Gln in CA IX) and 130 (Asp in CA II, Arg in CA IX) in selective CA inhibitor targeting.	Asparagine	62-65	carbonic anhydrase 2	Homo sapiens	69-74
30297880-6	2019	LASSO identified asparagine as a predictor of decreasing C-peptide (beta = -0.33) and CP-IR (beta = -0.012), and acetyl-carnitine (beta = 2.098), 4-hydroxyproline (beta = -0.050), ornithine (beta = -0.353), and alpha-aminoisobutyric acid (beta = -0.793) as determinants of TC in boys.	Asparagine	17-27	insulin	Homo sapiens	57-66
30297880-9	2019	LASSO identified asparagine, which influences growth hormone secretion, as a determinant of decreasing C-peptide and CP-IR in boys, and metabolites on lipid metabolism pathways as determinants of decreasing cholesterol in both sexes.	Asparagine	17-27	growth hormone 1	Homo sapiens	46-60
30297880-9	2019	LASSO identified asparagine, which influences growth hormone secretion, as a determinant of decreasing C-peptide and CP-IR in boys, and metabolites on lipid metabolism pathways as determinants of decreasing cholesterol in both sexes.	Asparagine	17-27	insulin	Homo sapiens	103-112
30634463-2	2019	ASNase"s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are converted to aspartic acid (Asp) and glutamic acid (Glu), respectively, in the blood.	Asparagine	81-84	asparaginase like 1	Mus musculus	0-6
30723747-3	2019	In this study, we isolated a new oligopeptide with nine amino acids Leu-Met-Thr-Phe-Arg-Asn-Glu-Gly-Thr from avian bursa following RP-HPLC, MODIL-TOP-MS, and MS/MS, which was named after BP9.	Asparagine	88-91	immunoglobulin kappa chain variable 9-119	Mus musculus	187-190
30607513-2	2019	The mutation is located in the activation loop (A-loop) region of the c-Met kinase domain, which substitutes the negatively charged residue Asp1228 with electroneutral amino acid Val, His, or Asn, thus electrostatically destabilizing the DFG-in conformation of A-loop and inducing its transition to DFG-out state.	Asparagine	192-195	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
30232643-1	2019	PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).	Asparagine	90-100	leucine rich repeat containing G protein-coupled receptor 6	Homo sapiens	49-70
30994606-5	2019	The obtained results demonstrated direct cause-and-effect relationships between polymorphisms lys-198 asn in the END-1 gene, C60T, T58C in the SOD-2 gene and the function of vascular access.	Asparagine	102-105	endothelin 1	Homo sapiens	113-118
30994606-6	2019	The presence of END-1 gene lys-198 asn polymorphism in a homozygous state (allele 1) was associated with a high risk of an unsatisfactory condition of permanent vascular access (p=0.019).	Asparagine	35-38	endothelin 1	Homo sapiens	16-21
30692827-7	2019	The nucleotide substitution in exon 1 introduces a one amino acid substitution at residue 2 where an aspartic acid (D) in DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140.	Asparagine	157-167	major histocompatibility complex, class II, DR beta 1	Homo sapiens	122-126
30692827-7	2019	The nucleotide substitution in exon 1 introduces a one amino acid substitution at residue 2 where an aspartic acid (D) in DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140.	Asparagine	157-167	major histocompatibility complex, class II, DR beta 1	Homo sapiens	175-179
30232643-1	2019	PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).	Asparagine	90-100	follicle stimulating hormone receptor	Homo sapiens	128-165
30232643-1	2019	PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).	Asparagine	90-100	follicle stimulating hormone receptor	Homo sapiens	167-171
30232643-1	2019	PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).	Asparagine	90-100	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	202-259
30232643-1	2019	PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).	Asparagine	90-100	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	261-266
31527367-10	2019	It is known that increased extracellular glucose levels enhance Cav3.2 activity through asparagine (N)-linked glycosylation of Cav3.2, which might contribute to diabetic neuropathy.	Asparagine	88-98	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	64-70
30727907-1	2019	BACKGROUND: L-asparaginase (L-ASN) is an anti-cancer enzyme therapeutic drug that exerts cytotoxicity via inhibition of protein synthesis through depletion of L-asparagine in the tumor microenvironment.	Asparagine	159-171	asparaginase and isoaspartyl peptidase 1	Homo sapiens	12-26
30727907-6	2019	The molecular dynamics analysis revealed intricate interactions required in the coupling of PEG to L-asparaginase to bestow stronger binding affinity of L-asparagine moiety towards L-asparaginase.	Asparagine	153-165	asparaginase and isoaspartyl peptidase 1	Homo sapiens	99-113
30727907-6	2019	The molecular dynamics analysis revealed intricate interactions required in the coupling of PEG to L-asparaginase to bestow stronger binding affinity of L-asparagine moiety towards L-asparaginase.	Asparagine	153-165	asparaginase and isoaspartyl peptidase 1	Homo sapiens	181-195
31041876-9	2019	Genetic analysis revealed an aspartic acid to asparagine mutation, D109N, in the beta2-subunit.	Asparagine	46-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	81-86
31527367-10	2019	It is known that increased extracellular glucose levels enhance Cav3.2 activity through asparagine (N)-linked glycosylation of Cav3.2, which might contribute to diabetic neuropathy.	Asparagine	88-98	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	127-133
30574022-8	2018	Results: CD200R1 was N-glycosylated at Asparagine 44 (Asn44, N44).	Asparagine	39-49	CD200 receptor 1	Homo sapiens	9-16
30373773-8	2018	Substitutions of individual amino acids within this region demonstrated that residues Asn-37, Thr-40, and Asp-42 of the murine cytokine were responsible for limited LIFR activation and absence of human OSMR/LIFR signaling.	Asparagine	86-89	LIF receptor alpha	Mus musculus	165-169
29924583-3	2018	Herein, stereochemical modifications of the Arg-Phe-Phe sequence were examined in the octapeptide AGRP-derived macrocyclic scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was Asn or diaminopropionic acid (Dap).	Asparagine	183-186	agouti related neuropeptide	Homo sapiens	98-102
30081188-4	2018	In this investigation, we report that Tomato leaf curl New Delhi virus-derived AC4 protein suppresses RNA silencing activity and mutational analysis of AC4 showed that Asn-50 in the SKNT-51 motif, in the C-terminal region, is a critical determinant of its RNA silencing suppressor activity.	Asparagine	168-171	AC4 protein	Tomato leaf curl New Delhi virus	79-82
30081188-4	2018	In this investigation, we report that Tomato leaf curl New Delhi virus-derived AC4 protein suppresses RNA silencing activity and mutational analysis of AC4 showed that Asn-50 in the SKNT-51 motif, in the C-terminal region, is a critical determinant of its RNA silencing suppressor activity.	Asparagine	168-171	AC4 protein	Tomato leaf curl New Delhi virus	152-155
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	55-65	basigin (Ok blood group)	Homo sapiens	96-101
30244971-4	2018	The mTORC1/4E-BP axis regulates aspartate, asparagine, and serine synthesis by modulating mRNA translation, while ablation of 4E-BP1/2 substantially decreases sensitivity of breast cancer and melanoma cells to KI/biguanide combinations.	Asparagine	43-53	CREB regulated transcription coactivator 1	Mus musculus	4-10
30192950-1	2018	This study provides first insights into the biosynthesis, structure, biochemistry and complex processing of the proteins encoded by hNOT/ALG3, the human counterpart of the Drosophila Neighbour of TID (NOT) and the yeast asparagine linked glycosylation 3 gene (ALG3), which encodes a mannosyltransferase.	Asparagine	220-230	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	137-141
30506915-5	2018	RESULTS: Sequencing analysis revealed a missense pathogenic variation c.301 G&gt;A in exon 2 of LCAT gene in all patients changing the amino acid aspartate to asparagine at the conserved position of amino acid 101 of LCAT protein.	Asparagine	159-169	lecithin-cholesterol acyltransferase	Homo sapiens	96-100
30506915-5	2018	RESULTS: Sequencing analysis revealed a missense pathogenic variation c.301 G&gt;A in exon 2 of LCAT gene in all patients changing the amino acid aspartate to asparagine at the conserved position of amino acid 101 of LCAT protein.	Asparagine	159-169	lecithin-cholesterol acyltransferase	Homo sapiens	217-221
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	55-65	basigin (Ok blood group)	Homo sapiens	221-226
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	67-70	basigin (Ok blood group)	Homo sapiens	96-101
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Asparagine	26-29	MADS-box transcription factor 47	Zea mays	9-12
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Asparagine	26-29	MADS-box transcription factor 47	Zea mays	164-167
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Asparagine	34-37	MADS-box transcription factor 47	Zea mays	9-12
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Asparagine	34-37	MADS-box transcription factor 47	Zea mays	164-167
30480096-7	2018	We also find that glutamine is diverted to asparagine via asparagine synthetase (ASNS).	Asparagine	43-53	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	58-79
30312994-6	2018	Through a combination of proteomics approaches and 13 C-methionine tracing, we observed oxidation-induced increases in both Asn deamidation to Asp and formation of methyl-Asp on key structural proteins and enzymes, including Band 3, hemoglobin, ankyrin, 4.1, spectrin beta, aldolase, glyceraldehyde 3-phosphate dehydrogenase, biphosphoglycerate mutase, lactate dehydrogenase and catalase.	Asparagine	124-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	284-324
30312994-6	2018	Through a combination of proteomics approaches and 13 C-methionine tracing, we observed oxidation-induced increases in both Asn deamidation to Asp and formation of methyl-Asp on key structural proteins and enzymes, including Band 3, hemoglobin, ankyrin, 4.1, spectrin beta, aldolase, glyceraldehyde 3-phosphate dehydrogenase, biphosphoglycerate mutase, lactate dehydrogenase and catalase.	Asparagine	124-127	catalase	Homo sapiens	379-387
30480096-7	2018	We also find that glutamine is diverted to asparagine via asparagine synthetase (ASNS).	Asparagine	43-53	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	81-85
30480096-9	2018	We find that silencing of Asns is lethal in Pkd1-mutant cells when combined with glucose deprivation, suggesting therapeutic approaches for ADPKD.	Asparagine	26-30	polycystin 1, transient receptor potential channel interacting	Homo sapiens	44-48
29125030-5	2018	Moreover, the residue interaction networks analysis, the hydrogen bond occupancy analysis and the binding free energies were calculated to gain detailed insight into the influence of the mutant D61G on the two regions, revealing that the major differences between SHP2-WT and SHP2-D61G were the different interactions between Gly 61 and Gly 462, Gly 61 and Ala 461, Gln 506 and Ile 463, Gly 61 and Asn 58, Ile 463 and Thr 466, Gly 462 and Cys 459.	Asparagine	398-401	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	276-280
30155702-1	2018	L-asparaginase or ASNase (L-asparagine aminohydrolase, E.C.3.5.1.1) is an enzyme clinically accepted as an antitumor agent to treat acute lymphoblastic leukemia (ALL) and lymphosarcoma through the depletion of L-asparagine (L-Asn) resulting in cytotoxicity to leukemic cells.	Asparagine	26-38	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
30155702-1	2018	L-asparaginase or ASNase (L-asparagine aminohydrolase, E.C.3.5.1.1) is an enzyme clinically accepted as an antitumor agent to treat acute lymphoblastic leukemia (ALL) and lymphosarcoma through the depletion of L-asparagine (L-Asn) resulting in cytotoxicity to leukemic cells.	Asparagine	224-229	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
30335983-6	2018	As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS versus Asn in eNOS is largely responsible for controlling selectivity.	Asparagine	96-99	nitric oxide synthase 1	Homo sapiens	84-88
30335983-6	2018	As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS versus Asn in eNOS is largely responsible for controlling selectivity.	Asparagine	96-99	nitric oxide synthase 3	Homo sapiens	103-107
30333107-0	2018	A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine.	Asparagine	87-97	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-44
30333107-4	2018	Here we suggest a hypothetical molecular mechanism for TRPV1 activation, which involves rotation of a conserved asparagine in S6 from a position facing the S4-S5 linker toward the pore.	Asparagine	112-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
30389987-7	2018	Further, the carboxylate group of a conserved aspartate of PglB mediates an interaction network between the reducing-end sugar of the LLO, the asparagine side chain of the acceptor peptide, and a bound divalent metal ion.	Asparagine	143-153	epiphycan	Homo sapiens	59-63
30483387-6	2018	The significant metabolites in the PTC group compared to healthy subjects also included scyllo- and myo-inositol, tryptophan, propionate, lactate, homocysteine, 3-methyl glutaric acid, asparagine, aspartate, choline, and acetamide.	Asparagine	185-195	coiled-coil domain containing 6	Homo sapiens	35-38
30279180-3	2018	Mutation of aspartic acid 262 of hnRNPA1 to either valine or asparagine has been linked to either amyotrophic lateral sclerosis or multisystem proteinopathy.	Asparagine	61-71	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	33-40
30213862-3	2018	Three recent reports indicate that the composition of the asparagine-linked carbohydrate chains (N-glycans) of FcgammaRIIIa/CD16a impacted IgG1-binding affinity.	Asparagine	58-68	Fc gamma receptor IIIa	Homo sapiens	111-123
30213862-3	2018	Three recent reports indicate that the composition of the asparagine-linked carbohydrate chains (N-glycans) of FcgammaRIIIa/CD16a impacted IgG1-binding affinity.	Asparagine	58-68	Fc gamma receptor IIIa	Homo sapiens	124-129
30279180-4	2018	Mutation of aspartic acid 378 of hnRNPDL to either asparagine or histidine has been associated with limb girdle muscular dystrophy.	Asparagine	51-61	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	33-40
30030107-1	2018	Mammalian asparagine endopeptidase (AEP) is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine.	Asparagine	10-20	legumain	Mus musculus	36-39
30054298-6	2018	Protein modeling suggests that removing the highly conserved asparagine residue alters BICD2 protein structure.	Asparagine	61-71	BICD cargo adaptor 2	Homo sapiens	87-92
29878070-0	2018	Optimization of a Precolumn OPA Derivatization HPLC Assay for Monitoring of l-Asparagine Depletion in Serum during l-Asparaginase Therapy.	Asparagine	76-88	asparaginase and isoaspartyl peptidase 1	Homo sapiens	115-129
29878070-6	2018	And the corresponding derivative products were stable up to 19 h. The validated method had been successfully applied to monitor ASN depletion and l-aspartic acid, l-glutamine, l-glutamic acid levels in pediatric patients during l-asparaginase therapy.	Asparagine	128-131	asparaginase and isoaspartyl peptidase 1	Homo sapiens	228-242
30229907-1	2018	3-Aminopropanamide (3-APA) is the direct precursor of acrylamide produced in the Maillard reaction between asparagine and reducing sugars.	Asparagine	107-117	glutamyl aminopeptidase	Homo sapiens	22-25
30148961-1	2018	FIH [factor inhibiting HIF (hypoxia inducible factor)] is an alpha-ketoglutarate (alphaKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the C-terminal transactivation domain (CAD) asparagine residue in HIF-1alpha to regulate cellular oxygen levels.	Asparagine	201-211	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-233
29746976-1	2018	Legumain (LGMN) is a lysosomal protease that can specifically hydrolyze proteins after carboxyl-terminal asparagine residues.	Asparagine	105-115	legumain	Homo sapiens	0-8
29966654-2	2018	l-asparaginase is an anti-cancer enzyme that deprives the cancer cells of l-asparagine.	Asparagine	74-86	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
29966654-3	2018	The purpose of this study was to explore the mechanism of a novel l-asparaginase from Pseudomonas fluorescens on l-asparagine deprivation mediated anti-proliferation, apoptosis in human gastric adenocarcinoma cells and to evaluate inhibition of angiogenesis.	Asparagine	113-125	asparaginase and isoaspartyl peptidase 1	Homo sapiens	66-80
29966654-5	2018	l-asparagine deprivation by l-asparaginase induced metabolic stress, cytotoxicity and apoptosis by G0 phase cell-cycle arrest, modulated the mitochondrial membrane integrity, accelerated caspase-3 activation and instigated DNA damage.	Asparagine	0-12	asparaginase and isoaspartyl peptidase 1	Homo sapiens	28-42
29966654-5	2018	l-asparagine deprivation by l-asparaginase induced metabolic stress, cytotoxicity and apoptosis by G0 phase cell-cycle arrest, modulated the mitochondrial membrane integrity, accelerated caspase-3 activation and instigated DNA damage.	Asparagine	0-12	caspase 3	Homo sapiens	187-196
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Asparagine	162-165	fibronectin 1	Homo sapiens	0-11
29905794-4	2018	The protein determinant of [SWI+], Swi1 was found to contain an amino-terminal, asparagine-rich prion domain.	Asparagine	80-90	Swi1p	Saccharomyces cerevisiae S288C	35-39
29573323-1	2018	A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human alpha5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.	Asparagine	98-108	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	42-48
30041084-12	2018	By contrast, the presence of PEPCK in maize roots and kernels was associated with either ammonium or asparagine metabolism.	Asparagine	101-111	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	29-34
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Asparagine	192-202	glutathione S-transferase omega 1	Homo sapiens	85-90
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Asparagine	192-202	glutathione S-transferase omega 2	Homo sapiens	161-166
29991592-4	2018	We identified a highly conserved, 13-residue segment (ADP-1) from adiponectin"s collagen domain, which comprises GXXG motifs and has one asparagine and two histidine residues that assist in oligomeric protein assembly.	Asparagine	137-147	adiponectin, C1Q and collagen domain containing	Mus musculus	66-77
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Asparagine	162-165	fibronectin 1	Homo sapiens	13-15
30016589-2	2018	Core fucosylation, a prevalent modification to the asparagine (N)-linked carbohydrate on the IgG1 crystallizable fragment (Fc), decreases the Fc gamma receptor IIIa (CD16a) binding affinity and mAb efficacy.	Asparagine	51-61	Fc gamma receptor IIIa	Homo sapiens	142-164
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Asparagine	87-90	protein tyrosine phosphatase receptor type J	Homo sapiens	62-67
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Asparagine	87-90	protein tyrosine phosphatase receptor type J	Homo sapiens	133-138
30016589-2	2018	Core fucosylation, a prevalent modification to the asparagine (N)-linked carbohydrate on the IgG1 crystallizable fragment (Fc), decreases the Fc gamma receptor IIIa (CD16a) binding affinity and mAb efficacy.	Asparagine	51-61	Fc gamma receptor IIIa	Homo sapiens	166-171
29614860-3	2018	We identified an AbetaO-subclass epitope defined by differential solvent orientation of the lysine 28 side chain in a constrained loop of serine-asparagine-lysine (cSNK), rarely displayed in molecular dynamics simulations of monomer and fibril ensembles.	Asparagine	145-155	casein kappa	Mus musculus	164-168
29989630-5	2018	This critical histidine-to-asparagine substitution, at residue 43, was proposed to underlie manganese transport specificity of SLC30A10.	Asparagine	27-37	solute carrier family 30 member 10	Homo sapiens	127-135
29752565-13	2018	The higher inhibitory potency of [Ala3]sialorphin than sialorphin against NEP is caused by removal of the hydrophilic residue (Asn) and a better fit of the peptide to the enzyme-binding pocket.	Asparagine	127-130	membrane metalloendopeptidase	Homo sapiens	74-77
30105045-8	2018	In contrast, substitution of Asp-205 by Asn in EpHKT1;2 did not enhance salt tolerance and rather resulted in a similar function to that of AtHKT1 (Na+ influx but no K+ influx), indicating that the presence of Asn or Asp determines the mode of cation selectivity of the HKT1-type transporters.	Asparagine	40-43	high-affinity K+ transporter 1	Arabidopsis thaliana	49-53
29959184-2	2018	PIP5K is essential for the development of the human neuronal system, which has been exemplified by a recessive genetic disorder, lethal congenital contractural syndrome type 3, caused by a single aspartate-to-asparagine mutation in the kinase domain of PIP5Kgamma.	Asparagine	209-219	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	0-5
29959184-2	2018	PIP5K is essential for the development of the human neuronal system, which has been exemplified by a recessive genetic disorder, lethal congenital contractural syndrome type 3, caused by a single aspartate-to-asparagine mutation in the kinase domain of PIP5Kgamma.	Asparagine	209-219	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	Homo sapiens	253-263
30092200-7	2018	Mutational analyses identified a single asparagine in human and mouse cGAS that is not conserved in many non-human primates.	Asparagine	40-50	cyclic GMP-AMP synthase	Mus musculus	70-74
29915028-0	2018	Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.	Asparagine	83-93	purine nucleoside phosphorylase	Homo sapiens	40-71
30013101-2	2018	Here, we found that specific inhibition of AURKA by MLN8237-induced calpain-mediated Bax cleavage at N-terminal 33th asparagine (c-Bax) to promote apoptosis.	Asparagine	117-127	aurora kinase A	Homo sapiens	43-48
30013101-2	2018	Here, we found that specific inhibition of AURKA by MLN8237-induced calpain-mediated Bax cleavage at N-terminal 33th asparagine (c-Bax) to promote apoptosis.	Asparagine	117-127	BCL2 associated X, apoptosis regulator	Homo sapiens	85-88
30013101-2	2018	Here, we found that specific inhibition of AURKA by MLN8237-induced calpain-mediated Bax cleavage at N-terminal 33th asparagine (c-Bax) to promote apoptosis.	Asparagine	117-127	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
29915028-5	2018	An asparagine (Asn243) at the catalytic site is involved in purine leaving-group activation in the PNP catalytic mechanism.	Asparagine	3-13	purine nucleoside phosphorylase	Homo sapiens	99-102
29915028-6	2018	In a PNP produced with isotopically heavy asparagines, the chemical step is faster (kchemlight/kchemheavy = 0.78).	Asparagine	42-53	purine nucleoside phosphorylase	Homo sapiens	5-8
29915028-7	2018	When all amino acids in PNP are heavy except for the asparagines, the chemical step is also faster (kchemlight/kchemheavy = 0.71).	Asparagine	53-64	purine nucleoside phosphorylase	Homo sapiens	24-27
29767260-1	2018	Asparaginase like 1 (ASRGL1) protein belongs to the N-terminal nucleophile group, cleaving the isoaspartyl-dipeptides and L-asparagine by adding water.	Asparagine	122-134	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-19
29694915-2	2018	The rate of nonenzymatic deamidation of two asparagines in the anti-apoptotic protein Bcl-xL is accelerated by this increase in pH.	Asparagine	44-55	BCL2 like 1	Homo sapiens	86-92
29694915-3	2018	Deamidation of these asparagines is a signal for the degradation of Bcl-xL, which is a component of the apoptotic response to DNA damage.	Asparagine	21-32	BCL2 like 1	Homo sapiens	68-74
29767260-1	2018	Asparaginase like 1 (ASRGL1) protein belongs to the N-terminal nucleophile group, cleaving the isoaspartyl-dipeptides and L-asparagine by adding water.	Asparagine	122-134	asparaginase and isoaspartyl peptidase 1	Homo sapiens	21-27
29915530-4	2018	Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs.	Asparagine	142-152	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	185-190
29915530-4	2018	Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs.	Asparagine	142-152	glutamate ionotropic receptor NMDA type subunit 3A	Rattus norvegicus	258-264
29915530-4	2018	Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs.	Asparagine	142-152	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	310-316
29915530-4	2018	Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs.	Asparagine	209-219	glutamate ionotropic receptor NMDA type subunit 3A	Rattus norvegicus	258-264
29915530-4	2018	Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs.	Asparagine	209-219	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	310-316
29759551-10	2018	Additionally, glucocorticoids, asparaginase, anthracycline, vincristine and cytarabine that trans-repress gene expression, deprives cells of asparagine, triggers cell cycle arrest, influences cytochrome-P450 polymorphism and inhibits DNA polymerase, respectively, have been used in chemotherapy in ALL patients.	Asparagine	141-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	192-207
29257879-3	2018	The aim of this study was to explore the potential of replacing the disulfide bridge in chimeric AGRP-melanocortin peptide Tyr-c[Cys-His-d-Phe-Arg-Trp-Asn-Ala-Phe-Cys]-Tyr-NH2 (1) with 1,2,3-triazole moieties.	Asparagine	151-154	agouti related neuropeptide	Mus musculus	97-101
27549815-5	2018	Molecular docking reveals the binding interaction of beta-catenin and ganoderic acid A with GScore (-9.44), kcal/mol, lipophilic EvdW (-2.86), electro (-0.72), Glide emodel (-50.401), MM-GBSA (-87.441), H bond (-1.91) with Lys 180 and Asn 220 residues involved in hydrogen bonding.	Asparagine	235-238	catenin (cadherin associated protein), beta 1	Mus musculus	53-65
29777197-6	2018	We also investigated the effect the biologically important Hif-1alpha CAD Asn-803 hydroxylation has on the binding kinetics, and found that the whole destabilization effect due the hydroxylation is within the dissociation rate constant.	Asparagine	74-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
29664642-6	2018	Interestingly, we also found a novel intrinsic preference of cathepsin G for Asn at the P1 subsite, which we confirmed using synthetic peptides.	Asparagine	77-80	cathepsin G	Homo sapiens	61-72
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Asparagine	108-118	defensin beta 1	Homo sapiens	40-43
29719230-4	2018	(2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulatory pathways.	Asparagine	24-34	IL2 inducible T cell kinase	Homo sapiens	151-154
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Asparagine	108-118	defensin beta 4A	Homo sapiens	58-61
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Asparagine	108-118	bromodomain testis associated	Homo sapiens	66-70
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Asparagine	108-118	defensin beta 4A	Homo sapiens	122-125
29496997-6	2018	Moreover, substitutions of key residues, specifically Ile-915 and Asn-916, converted SDG8-CW binding preference from H3K4me1 to H3K4me3.	Asparagine	66-69	histone-lysine N-methyltransferase	Arabidopsis thaliana	85-89
29574076-9	2018	The internal irisin peptides were modified to the deamidated asparagine form after deglycosylation.	Asparagine	61-71	fibronectin type III domain containing 5	Homo sapiens	13-19
29666272-8	2018	Recognition arm interactions are similar to the enzyme-substrate interactions for Golgi alpha-mannosidase II, a glycoside hydrolase that acts just before MGAT2 in the Asn-linked glycan biosynthetic pathway.	Asparagine	167-170	mannosidase alpha class 2A member 1	Homo sapiens	82-108
29666272-8	2018	Recognition arm interactions are similar to the enzyme-substrate interactions for Golgi alpha-mannosidase II, a glycoside hydrolase that acts just before MGAT2 in the Asn-linked glycan biosynthetic pathway.	Asparagine	167-170	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	154-159
29337145-5	2018	Immunoprecipitation-mass spectrometry (IP-Mass) identified that ATP1B1 is bound to DCF1, and co-immunoprecipitation and cell fluorescence further confirmed an interaction between these two proteins, with asparagine residue 266 of ATP1B1 being required for the interaction with DCF1.	Asparagine	204-214	ATPase, Na+/K+ transporting, beta 1 polypeptide	Mus musculus	64-70
29765472-6	2018	The new conjugates showed lower chemostability against deamidation of Asn than the control compound, thus they had lower selectivity to CD13+ cells.	Asparagine	70-73	alanyl aminopeptidase, membrane	Homo sapiens	136-140
29502412-8	2018	Further, comparison of the current work to that of Zn2+ and Cd2+ complexes of asparagine (Asn) allows additional conclusions regarding populated conformers and effects of carboxamide versus carboxylic acid binding to be drawn.	Asparagine	78-88	CD2 molecule	Homo sapiens	60-63
29502412-8	2018	Further, comparison of the current work to that of Zn2+ and Cd2+ complexes of asparagine (Asn) allows additional conclusions regarding populated conformers and effects of carboxamide versus carboxylic acid binding to be drawn.	Asparagine	90-93	CD2 molecule	Homo sapiens	60-63
29605274-2	2018	l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related blood cancers.	Asparagine	38-50	asparaginase like 1	Mus musculus	0-14
29605274-8	2018	Decreases in plasma asparagine levels due to the administration of l-asparaginase were closely related to the dosing time-dependency of its anti-tumor effects.	Asparagine	20-30	asparaginase like 1	Mus musculus	67-81
29294313-4	2018	By using bioinformatics, mass spectrometry analysis, and co-immunoprecipitation assays, here we show that DENV-NS1 is ubiquitinated on multiples lysine residues during DENV infection, including K189, a lysine residue previously shown to be important for efficient DENV replication.	Asparagine	194-198	influenza virus NS1A binding protein	Homo sapiens	111-114
29485866-0	2018	O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.	Asparagine	60-70	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-20
29485866-3	2018	With this assay we examined the contribution to substrate selection of a conserved asparagine ladder within the lumen of OGT"s superhelical tetratricopeptide repeat (TPR) domain.	Asparagine	83-93	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	121-124
29485866-4	2018	When five asparagines were mutated, OGT retained significant activity against short peptides, but showed limited limited glycosylation of protein substrates on the microarray.	Asparagine	10-21	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	36-39
29485866-6	2018	We conclude that OGT recognizes the majority of its substrates by binding them to the asparagine ladder in the TPR lumen proximal to the catalytic domain.	Asparagine	86-96	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	17-20
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Asparagine	207-217	KN motif and ankyrin repeat domains 3	Homo sapiens	20-25
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Asparagine	207-217	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	67-109
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Asparagine	207-217	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	111-117
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Asparagine	207-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-151
29047187-4	2018	An in vitro hydroxylation assay clearly demonstrated asparaginyl hydroxylation of KANK3 by HIF1AN, and mass spectroscopic analysis revealed that KANK3 is hydroxylated at three asparagine residues within the ankyrin repeat domain.	Asparagine	176-186	KN motif and ankyrin repeat domains 3	Homo sapiens	145-150
29343523-2	2018	The enzyme drug l-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells.	Asparagine	87-97	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-30
29324974-7	2018	In addition, an ERAP2 variant in which lysine is changed to asparagine (K392N) results in increased trimming activity (165-fold) for hydrophobic peptides and biologically never been detected.	Asparagine	60-70	endoplasmic reticulum aminopeptidase 2	Homo sapiens	16-21
29283561-0	2018	Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.	Asparagine	55-65	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	11-18
29242193-6	2018	Moreover, we mapped two Asn residues within CRD4 that are N-linked glycosylated and mediate m4-1BB binding to Gal-9.	Asparagine	24-27	lectin, galactose binding, soluble 9	Mus musculus	110-115
28858842-4	2017	However, the complete deglycosylation of asparagine residues in vitro, including the residue in position 371, interrupts tyrosinase function, which is consistent with a melanin loss in oculocutaneous albinism type 1 (OCA1) patients.	Asparagine	41-51	tyrosinase	Homo sapiens	121-131
29379512-12	2017	The heterologously expressed TaASN1 and TaASN2 proteins were found to be active asparagine synthetases, producing asparagine and glutamate from glutamine and aspartate.	Asparagine	80-90	asparagine synthetase [glutamine-hydrolyzing]	Triticum aestivum	29-35
29308690-3	2018	Here we discuss our recent paper establishing similarities between aggregates of TDP-43 that have short glutamine and asparagine (Q/N)-rich modules and are soluble in detergents, with those of polyQ and PIN4C that have large Q/N-rich domains and are detergent-insoluble.	Asparagine	118-128	TAR DNA binding protein	Homo sapiens	81-87
29956571-6	2018	Metabolite profiles indicated a deficiency in the nonessential amino acid asparagine despite a compensatory overexpression of ASNS (asparagine synthetase), key enzyme for de novo asparagine synthesis.	Asparagine	132-142	asparagine synthetase	Mus musculus	126-130
29956571-7	2018	Inhibition of either autophagy or ASNS reduced KRASG12V-driven tumor cell proliferation, migration, and invasion, which was rescued by asparagine supplementation or knockdown of MFF (mitochondrial fission factor).	Asparagine	135-145	asparagine synthetase	Mus musculus	34-38
29956571-9	2018	Together, our data document a widespread yet specific asparagine homeostasis control by autophagy and ASNS, highlighting the previously unrecognized role of autophagy in suppressing the metabolic barriers of low asparagine and excessive mitochondrial fragmentation to permit malignant KRAS-driven tumor progression.	Asparagine	54-64	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	102-106
29956571-9	2018	Together, our data document a widespread yet specific asparagine homeostasis control by autophagy and ASNS, highlighting the previously unrecognized role of autophagy in suppressing the metabolic barriers of low asparagine and excessive mitochondrial fragmentation to permit malignant KRAS-driven tumor progression.	Asparagine	54-64	KRAS proto-oncogene, GTPase	Homo sapiens	285-289
28842428-4	2018	Asparagine synthetase (ASNS) was induced by endoplasmic reticulum stress, leading to the generation of asparagine, which inhibited lysosome acidification.	Asparagine	103-113	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
28842428-4	2018	Asparagine synthetase (ASNS) was induced by endoplasmic reticulum stress, leading to the generation of asparagine, which inhibited lysosome acidification.	Asparagine	103-113	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
28842428-8	2018	Impaired autophagy in NAFLD is elicited by defective lysosome acidification, which is caused by ASNS-induced asparagine synthesis under endoplasmic reticulum stress and subsequent retention of lysosomal calcium.	Asparagine	109-119	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	96-100
29155580-4	2017	To demonstrate the utility of our hybridization approach, two analogues containing unique Asn binders and the optimized tetrahydroquinoline moiety were rapidly optimized to yield single-digit nanomolar inhibitors of CBP with exquisite selectivity over BRD4(1) and the broader bromodomain family.	Asparagine	90-93	CREB binding protein	Homo sapiens	216-219
29187599-4	2018	Here, we show that Asn-110 in native hDAO from amniotic fluid and Caco-2 cells, DAO from porcine kidneys, and rhDAO produced in two different HEK293 cell lines is also consistently occupied by oligomannosidic glycans.	Asparagine	19-22	D-amino acid oxidase	Homo sapiens	38-41
29187599-11	2018	Because of their locations in the DAO structure, Asn-538 and Asn-745 glycosylations might be important for efficient DAO dimer formation.	Asparagine	49-52	D-amino acid oxidase	Homo sapiens	34-37
29187599-11	2018	Because of their locations in the DAO structure, Asn-538 and Asn-745 glycosylations might be important for efficient DAO dimer formation.	Asparagine	49-52	D-amino acid oxidase	Homo sapiens	117-120
29187599-11	2018	Because of their locations in the DAO structure, Asn-538 and Asn-745 glycosylations might be important for efficient DAO dimer formation.	Asparagine	61-64	D-amino acid oxidase	Homo sapiens	34-37
29187599-11	2018	Because of their locations in the DAO structure, Asn-538 and Asn-745 glycosylations might be important for efficient DAO dimer formation.	Asparagine	61-64	D-amino acid oxidase	Homo sapiens	117-120
29316436-0	2018	Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.	Asparagine	52-62	KRAS proto-oncogene, GTPase	Homo sapiens	10-14
29316436-0	2018	Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.	Asparagine	52-62	activating transcription factor 4	Homo sapiens	80-84
29316436-0	2018	Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.	Asparagine	52-62	asparaginase and isoaspartyl peptidase 1	Homo sapiens	111-125
29316436-4	2018	Through ATF4 regulation, KRAS alters amino acid uptake and asparagine biosynthesis.	Asparagine	59-69	activating transcription factor 4	Homo sapiens	8-12
29316436-4	2018	Through ATF4 regulation, KRAS alters amino acid uptake and asparagine biosynthesis.	Asparagine	59-69	KRAS proto-oncogene, GTPase	Homo sapiens	25-29
28988820-4	2017	ATF4 upregulation by p62 deficiency in the stroma activates glucose carbon flux through a pyruvate carboxylase-asparagine synthase cascade that results in asparagine generation as a source of nitrogen for stroma and tumor epithelial proliferation.	Asparagine	111-121	activating transcription factor 4	Homo sapiens	0-4
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	Asparagine	80-90	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	149-174
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	Asparagine	80-90	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	176-179
29084849-1	2017	Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Asparagine	65-75	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
29084849-1	2017	Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Asparagine	65-75	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
28988820-4	2017	ATF4 upregulation by p62 deficiency in the stroma activates glucose carbon flux through a pyruvate carboxylase-asparagine synthase cascade that results in asparagine generation as a source of nitrogen for stroma and tumor epithelial proliferation.	Asparagine	111-121	nucleoporin 62	Homo sapiens	21-24
28956227-7	2017	Our functional data indicate that the non-glycosylated NTPDase3/CD39L3 ecto-enzymatic domain retains activity, but that N-glycan attachments, such as the GlcNAc-Asn, substantially upregulate specific NTPDase activity by 2-20 fold.	Asparagine	161-164	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	55-63
28945321-1	2017	HLA-DRB1*14:127:02 has one nucleotide change from HLA-DRB1*14:05:01 where Threonine (77) is changed to Asparagine.	Asparagine	103-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
28945321-1	2017	HLA-DRB1*14:127:02 has one nucleotide change from HLA-DRB1*14:05:01 where Threonine (77) is changed to Asparagine.	Asparagine	103-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	50-58
28956227-7	2017	Our functional data indicate that the non-glycosylated NTPDase3/CD39L3 ecto-enzymatic domain retains activity, but that N-glycan attachments, such as the GlcNAc-Asn, substantially upregulate specific NTPDase activity by 2-20 fold.	Asparagine	161-164	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	64-70
29225432-10	2017	The active site amino acids such as TYR-21, ASN-34, VAL-35, MET-18, LYS-17, SER-36, ARG- 46 and ARG-14 are key role in the inhibitors activity.	Asparagine	44-47	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	60-66
29053695-3	2017	STIM1 undergoes post-translational N-glycosylation at two luminal Asn sites within the Ca2+ sensing domain of the molecule.	Asparagine	66-69	stromal interaction molecule 1	Homo sapiens	0-5
30023574-1	2017	Agricultural wastes such as the peels of onion and garlic were used as a supplement along with l-asparagine for the very first time to produce increased yield of l-asparaginase by Pseudomonas plecoglossicida RS1.	Asparagine	95-107	asparaginase and isoaspartyl peptidase 1	Homo sapiens	162-176
29045069-4	2017	Imputation was used to identify associations at HLA-C Asn80Lys (Asn, C1; Lys, C2) and KIR.	Asparagine	54-57	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	86-89
28963769-6	2017	The PER2-mediated activation of HIF-1 was observed only when the asparagine residue at position 803 of HIF-1alpha (HIF-1alpha N803) was kept unhydroxylated by hypoxic stimulation, by introducing an N803A point mutation, or by an inhibitor of N803-dioxygenase, deferoxamine.	Asparagine	65-75	period circadian regulator 2	Homo sapiens	4-8
28963769-6	2017	The PER2-mediated activation of HIF-1 was observed only when the asparagine residue at position 803 of HIF-1alpha (HIF-1alpha N803) was kept unhydroxylated by hypoxic stimulation, by introducing an N803A point mutation, or by an inhibitor of N803-dioxygenase, deferoxamine.	Asparagine	65-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
28963769-6	2017	The PER2-mediated activation of HIF-1 was observed only when the asparagine residue at position 803 of HIF-1alpha (HIF-1alpha N803) was kept unhydroxylated by hypoxic stimulation, by introducing an N803A point mutation, or by an inhibitor of N803-dioxygenase, deferoxamine.	Asparagine	65-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
28963769-6	2017	The PER2-mediated activation of HIF-1 was observed only when the asparagine residue at position 803 of HIF-1alpha (HIF-1alpha N803) was kept unhydroxylated by hypoxic stimulation, by introducing an N803A point mutation, or by an inhibitor of N803-dioxygenase, deferoxamine.	Asparagine	65-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
28731644-1	2017	HLA-A*24:198 has one nucleotide change from HLA-A*24:02:01 where aspartic acid (29) is changed to asparagine.	Asparagine	98-108	major histocompatibility complex, class I, A	Homo sapiens	0-5
28731644-1	2017	HLA-A*24:198 has one nucleotide change from HLA-A*24:02:01 where aspartic acid (29) is changed to asparagine.	Asparagine	98-108	major histocompatibility complex, class I, A	Homo sapiens	44-49
29156593-9	2017	However, mutations of four asparagine residues, potential glycosylation sites in chimera IRR with swapped FnIII-2/3 domains of IR, decreased the chimera glycosylation and resulted in a partial restoration of IRR pH-sensing activity, suggesting that the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.	Asparagine	27-37	insulin receptor related receptor	Homo sapiens	89-92
29156593-9	2017	However, mutations of four asparagine residues, potential glycosylation sites in chimera IRR with swapped FnIII-2/3 domains of IR, decreased the chimera glycosylation and resulted in a partial restoration of IRR pH-sensing activity, suggesting that the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.	Asparagine	27-37	insulin receptor related receptor	Homo sapiens	208-211
29156593-9	2017	However, mutations of four asparagine residues, potential glycosylation sites in chimera IRR with swapped FnIII-2/3 domains of IR, decreased the chimera glycosylation and resulted in a partial restoration of IRR pH-sensing activity, suggesting that the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.	Asparagine	27-37	insulin receptor related receptor	Homo sapiens	208-211
28964831-9	2017	Based on sequence and structural analyses, we predicted the significance of targeting human APN residues: Ala-351, Arg-442, Ala-474, Phe-896 and Asn-900 for improving the selectivity of the identified compounds.	Asparagine	145-148	alanyl aminopeptidase, membrane	Homo sapiens	92-95
28878088-8	2017	It is concluded that only animals homozygous for asparagine at codon 146 succumb to scrapie under natural conditions.IMPORTANCE In goats, like in sheep, there are PRNP polymorphisms that are associated with susceptibility or resistance to scrapie.	Asparagine	49-59	major prion protein	Ovis aries	163-167
28813605-3	2017	In this study, the Asn and Ala positions of a reported AGRP macrocyclic scaffold (c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro]) were explored with 14-compound and 8-compound libraries, respectively, to generate more potent, selective melanocortin receptor antagonists.	Asparagine	19-22	agouti related neuropeptide	Homo sapiens	55-59
28813605-4	2017	Substituting diaminopropionic acid (Dap), DDap, and His at the Asn position yielded potent MC4R ligands, while replacing Ala with Ser maintained MC4R potency.	Asparagine	63-66	melanocortin 4 receptor	Homo sapiens	91-95
28821532-9	2017	Asparagine at position 97 of HLA-B defines the HLA-B*27 alleles.	Asparagine	0-10	major histocompatibility complex, class I, B	Homo sapiens	29-34
28821532-9	2017	Asparagine at position 97 of HLA-B defines the HLA-B*27 alleles.	Asparagine	0-10	major histocompatibility complex, class I, B	Homo sapiens	47-52
28765898-9	2017	Additionally, cross-species comparison of amino acid sequence alignment of vimentin, as well as site-directed mutagenesis, revealed that one residue, the asparagine at position 417, is critical for antibody binding.	Asparagine	154-164	vimentin	Homo sapiens	75-83
28691394-1	2017	HLA-A*30:62 has one nucleotide change from HLA-A*30:01:01 where 311 Threonine (ACC) is changed to Asparagine (AAC).	Asparagine	98-108	major histocompatibility complex, class I, A	Homo sapiens	0-5
28691394-1	2017	HLA-A*30:62 has one nucleotide change from HLA-A*30:01:01 where 311 Threonine (ACC) is changed to Asparagine (AAC).	Asparagine	98-108	major histocompatibility complex, class I, A	Homo sapiens	43-48
28691394-1	2017	HLA-A*30:62 has one nucleotide change from HLA-A*30:01:01 where 311 Threonine (ACC) is changed to Asparagine (AAC).	Asparagine	98-108	glycine-N-acyltransferase	Homo sapiens	110-113
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Asparagine	65-68	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28922740-1	2017	In Campylobacter jejuni, the PglB oligosaccharyltransferase catalyzes the transfer of a heptasaccharide from a lipid donor to asparagine within the D/E-X1-N-X2-S/T sequon (X1,2   P) or releases this heptasaccharide as free oligosaccharides (fOS).	Asparagine	126-136	epiphycan	Homo sapiens	29-33
28765898-10	2017	Using smaller vimentin fragments ranging in length from 9 to 13 residues, each containing this critical asparagine, we determined that the minimal residues required for V9 mAb recognition of human vimentin are the thirteen amino acid residues at positions 411-423 (411ISLPLPNFSSLNL423).	Asparagine	104-114	vimentin	Homo sapiens	197-205
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Asparagine	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28816396-3	2017	Here, we report capillary electrophoresis-mass spectrometric (CE-MS) analysis for the separation and identification of MBP peptides that incorporate the same PTM at different sites, creating multiple localization variants, and the ability to analyze challenging modifications such as asparagine and glutamine deamidation, isomerization, and arginine citrullination.	Asparagine	284-294	myelin basic protein	Mus musculus	119-122
28979182-4	2017	It is found that glycine N-methylation of NGR-tagged nanocarriers completely prevents asparagine deamidation without impairing CD13 recognition.	Asparagine	86-96	reticulon 4 receptor	Homo sapiens	42-45
29254168-5	2017	Targeted metabolomics including 24 metabolites revealed that most tricarboxylic acid (TCA) cycle intermediates, aspartate-derived asparagine, alanine and ornithine-derived polyamines were strongly down-regulated in SLC25A22 knockdown cells.	Asparagine	130-140	solute carrier family 25 member 22	Homo sapiens	215-223
28741928-2	2017	Iterative deconvolution in solution of synthesized modified pentapeptides yielded two potent HtrA3 activators acting in the micromolar range (HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Asn-OH and HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Glu-OH).	Asparagine	181-187	HtrA serine peptidase 3	Homo sapiens	93-98
28910420-4	2017	Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc.	Asparagine	106-117	prion protein	Rattus norvegicus	53-57
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor Ia	Homo sapiens	124-133
28729420-6	2017	However, Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide context, such as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moiety.	Asparagine	255-258	fucosyltransferase 8	Homo sapiens	69-73
28729420-6	2017	However, Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide context, such as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moiety.	Asparagine	255-258	erythropoietin	Homo sapiens	134-148
28880909-5	2017	The focus of this analysis was the site-specific glycosylation at asparagine (Asn) 52 of the alpha-subunit of FSH, owing to the pivotal role of Asn52 glycosylation in FSH receptor (FSHR) activation/signalling.	Asparagine	66-76	follicle stimulating hormone receptor	Homo sapiens	167-179
28880909-5	2017	The focus of this analysis was the site-specific glycosylation at asparagine (Asn) 52 of the alpha-subunit of FSH, owing to the pivotal role of Asn52 glycosylation in FSH receptor (FSHR) activation/signalling.	Asparagine	66-76	follicle stimulating hormone receptor	Homo sapiens	181-185
28880909-5	2017	The focus of this analysis was the site-specific glycosylation at asparagine (Asn) 52 of the alpha-subunit of FSH, owing to the pivotal role of Asn52 glycosylation in FSH receptor (FSHR) activation/signalling.	Asparagine	78-81	follicle stimulating hormone receptor	Homo sapiens	167-179
28880909-5	2017	The focus of this analysis was the site-specific glycosylation at asparagine (Asn) 52 of the alpha-subunit of FSH, owing to the pivotal role of Asn52 glycosylation in FSH receptor (FSHR) activation/signalling.	Asparagine	78-81	follicle stimulating hormone receptor	Homo sapiens	181-185
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor IIa	Homo sapiens	124-135
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor and transporter	Homo sapiens	203-207
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor IIb	Homo sapiens	137-148
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor IIIa	Homo sapiens	150-162
28932620-1	2017	The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [Baker E. N.J. Mol.	Asparagine	91-101	cathepsin B	Homo sapiens	4-21
28979843-4	2017	Interestingly, we found that asparagine deamidation (D-N) reduced the binding of IgG to the low-affinity Fcgamma receptors (FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, and FcgammaRIIIb), while FcgammaRI and FcRn binding was not impacted.	Asparagine	29-39	Fc gamma receptor IIIb	Homo sapiens	168-180
28697948-3	2017	To ensure adequate asparagine depletion, the use of therapeutic drug monitoring of asparaginase therapy holds much promise, yet remains underutilized in practice.	Asparagine	19-29	asparaginase	Homo sapiens	83-95
28668641-1	2017	Vaspin is a glycoprotein with three predicted glycosylation sites at asparagine residues located in proximity to the reactive center loop and close to domains that play important roles in conformational changes underlying serpin function.	Asparagine	69-79	serpin family A member 12	Homo sapiens	0-6
27866376-2	2017	This reaction occurs when carbohydrate-rich foods are heated at temperatures above 120  C. Multiple potato varieties were transformed with potato genomic DNA that results in down-regulation of the expression of the asparagine synthetase-1 gene (Asn1), significantly reducing synthesis of free Asn, and consequently lowering the potential to form acrylamide during cooking.	Asparagine	245-248	asparagine synthetase [glutamine-hydrolyzing]	Solanum tuberosum	215-238
28585176-6	2017	Asn-9 lies within a hydrophobic pocket that is formed by Met-36, Thr-59, and Phe-119 of the rat beta2 subunit in the alpha3beta2 nAChR model, revealing the reason for its more potent selectivity towards the alpha3beta2 nAChR subtype.	Asparagine	0-3	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	129-134
28585176-6	2017	Asn-9 lies within a hydrophobic pocket that is formed by Met-36, Thr-59, and Phe-119 of the rat beta2 subunit in the alpha3beta2 nAChR model, revealing the reason for its more potent selectivity towards the alpha3beta2 nAChR subtype.	Asparagine	0-3	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	219-224
28772203-1	2017	The role of a highly conserved active site asparagine (N79) in the ubiquitin conjugating enzyme, Ubc13, is probed using molecular dynamics simulations.	Asparagine	43-53	ubiquitin conjugating enzyme E2 N	Homo sapiens	97-102
28619748-5	2017	Mutagenesis analysis in Kir1.1 revealed that asparagine 171 (N171) is the only pore-lining residue required for high-affinity block, and that substituting negatively charged residues (N171D, N171E) at this position dramatically weakens block.	Asparagine	45-55	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	24-30
28671681-5	2017	Critically, we show that Asrgl1 activity is selective for asparagine and is devoid of glutaminase activity.	Asparagine	58-68	asparaginase and isoaspartyl peptidase 1	Homo sapiens	25-31
28273031-9	2017	The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p &lt;= 0.046).	Asparagine	57-60	interleukin 1 beta	Rattus norvegicus	9-17
28659375-6	2017	While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitrogen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagine.	Asparagine	22-32	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	44-65
28617578-3	2017	We establish that MUC16 oncogenic effects are mediated through MGAT5-dependent N-glycosylation of two specific asparagine sites within its 58 amino acid ectodomain.	Asparagine	111-121	mucin 16, cell surface associated	Homo sapiens	18-23
28617578-3	2017	We establish that MUC16 oncogenic effects are mediated through MGAT5-dependent N-glycosylation of two specific asparagine sites within its 58 amino acid ectodomain.	Asparagine	111-121	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	63-68
28659375-6	2017	While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitrogen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagine.	Asparagine	44-54	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	67-71
28659375-6	2017	While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitrogen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagine.	Asparagine	44-54	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	67-71
28659375-7	2017	Asparagine further proved crucial in glutamine-deprived ECs to restore protein synthesis, suppress ER stress, and reactivate mTOR signaling.	Asparagine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	125-129
28659379-8	2017	Mechanistically, addition of exogenous alpha-ketoglutarate replenishes TCA intermediates and rescues cellular growth, but simultaneously unveils a requirement for Rac1-dependent macropinocytosis to provide non-essential amino acids, including asparagine.	Asparagine	243-253	Rac family small GTPase 1	Mus musculus	163-167
28620050-4	2017	Hexa-Fc contains two N-linked sites at Asn-77 (equivalent to Asn-297 in the Fc of IgG1) and Asn-236 (equivalent to Asn-563 in the tail piece of IgM).	Asparagine	61-64	hexosaminidase subunit alpha	Homo sapiens	0-4
28807563-3	2017	Using mass spectrometry, we show that in virus particles of a Lelystad variant, the signal peptide of GP5 was absent due to cleavage between glycine-34 and asparagine-35.	Asparagine	156-166	glycoprotein V platelet	Homo sapiens	102-105
28620050-4	2017	Hexa-Fc contains two N-linked sites at Asn-77 (equivalent to Asn-297 in the Fc of IgG1) and Asn-236 (equivalent to Asn-563 in the tail piece of IgM).	Asparagine	39-42	hexosaminidase subunit alpha	Homo sapiens	0-4
28811348-6	2017	Specifically, glutamine and asparagine provide the critical gamma-nitrogen for purine and pyrimidine biosynthesis, as knockdown of four rate-limiting enzymes in the pathways, including carbamoylphosphate synthetase 2 (CAD), phosphoribosyl pyrophosphate amidotransferase (PPAT), and phosphoribosyl pyrophosphate synthetases 1 and 2 (PRPS1 and PRPS2, respectively), suppresses cell proliferation.	Asparagine	28-38	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	239-269
28811348-6	2017	Specifically, glutamine and asparagine provide the critical gamma-nitrogen for purine and pyrimidine biosynthesis, as knockdown of four rate-limiting enzymes in the pathways, including carbamoylphosphate synthetase 2 (CAD), phosphoribosyl pyrophosphate amidotransferase (PPAT), and phosphoribosyl pyrophosphate synthetases 1 and 2 (PRPS1 and PRPS2, respectively), suppresses cell proliferation.	Asparagine	28-38	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	271-275
28811348-6	2017	Specifically, glutamine and asparagine provide the critical gamma-nitrogen for purine and pyrimidine biosynthesis, as knockdown of four rate-limiting enzymes in the pathways, including carbamoylphosphate synthetase 2 (CAD), phosphoribosyl pyrophosphate amidotransferase (PPAT), and phosphoribosyl pyrophosphate synthetases 1 and 2 (PRPS1 and PRPS2, respectively), suppresses cell proliferation.	Asparagine	28-38	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	332-337
28811348-6	2017	Specifically, glutamine and asparagine provide the critical gamma-nitrogen for purine and pyrimidine biosynthesis, as knockdown of four rate-limiting enzymes in the pathways, including carbamoylphosphate synthetase 2 (CAD), phosphoribosyl pyrophosphate amidotransferase (PPAT), and phosphoribosyl pyrophosphate synthetases 1 and 2 (PRPS1 and PRPS2, respectively), suppresses cell proliferation.	Asparagine	28-38	phosphoribosyl pyrophosphate synthetase 2	Homo sapiens	342-347
28904867-0	2017	The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation.	Asparagine	4-14	polycystic kidney disease 2-like 1	Mus musculus	70-76
28904867-3	2017	Here, we found that the mutation of an asparagine 533 residue (N533Q) in the outer pore loop region of PKD2L1 caused a marked increase in outward currents induced by depolarization.	Asparagine	39-49	polycystic kidney disease 2-like 1	Mus musculus	103-109
28620050-4	2017	Hexa-Fc contains two N-linked sites at Asn-77 (equivalent to Asn-297 in the Fc of IgG1) and Asn-236 (equivalent to Asn-563 in the tail piece of IgM).	Asparagine	61-64	hexosaminidase subunit alpha	Homo sapiens	0-4
28620050-4	2017	Hexa-Fc contains two N-linked sites at Asn-77 (equivalent to Asn-297 in the Fc of IgG1) and Asn-236 (equivalent to Asn-563 in the tail piece of IgM).	Asparagine	61-64	hexosaminidase subunit alpha	Homo sapiens	0-4
28600229-1	2017	Recently, linkage analysis of two large unrelated multigenerational families identified a novel dilated cardiomyopathy (DCM)-linked mutation in the gene coding for alpha-tropomyosin (TPM1) resulting in the substitution of an aspartic acid for an asparagine (at residue 230).	Asparagine	246-256	tropomyosin 1	Homo sapiens	164-181
28745503-0	2017	Correction to "Experimental and Theoretical Investigations of Infrared Multiple Photon Dissociation Spectra of Asparagine Complexes with Zn2+ and Cd2+ and Their Deamidation Processes".	Asparagine	111-121	CD2 molecule	Homo sapiens	146-149
28390103-6	2017	In transgenic Arabidopsis expressing promoterCaMV35S ::ASN1 fusion, marked metabolomics changes at stage 0, including a several-fold increase in free asparagine, are correlated to enhanced seed nitrogen.	Asparagine	150-160	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	55-59
28390103-7	2017	However, specific promoterNapin2S ::ASN1 expression during seed formation and a six-fold increase in asparagine toward the desiccation stage result in wild-type seed nitrogen, underlining that delayed accumulation of asparagine impairs the timing of its use by releasing amide and amino nitrogen.	Asparagine	217-227	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	36-40
28720870-2	2017	Proteins containing an Asn-Gly-Arg (NGR) motif readily undergo deamidation of asparagine to generate isoDGR structures that bind to integrin alphavbeta3 on circulating leukocytes.	Asparagine	78-88	integrin subunit alpha V	Homo sapiens	132-152
28614667-0	2017	N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.	Asparagine	19-29	calcitonin receptor	Homo sapiens	75-94
28067406-7	2017	Ninj1 N-glycosylation was characterized by treatment of tunicamycin and substitution of Asn to Gln or Ala.	Asparagine	88-91	ninjurin 1	Homo sapiens	0-5
28067406-8	2017	Fluorescence-activated cell sorting-based Forster resonance energy transfer assays further demonstrated that N-glycosylation is indispensable for the Ninj1 cis-interaction, and a formaldehyde cross-linking assay confirmed that interruption of N-glycosylation by Asn substitution disrupted Ninj1 homomeric complex formation.	Asparagine	262-265	ninjurin 1	Homo sapiens	150-155
28665109-3	2017	In this study, we investigated the effects of site-specific Asn deamidation on the amyloidogenicity of the aggregation-prone peptide islet amyloid polypeptide (IAPP).	Asparagine	60-63	islet amyloid polypeptide	Rattus norvegicus	160-164
28665109-7	2017	In contrast, IAPP was somewhat tolerant to the successive deamidation of Asn residues 22, 31, and 35.	Asparagine	73-76	islet amyloid polypeptide	Rattus norvegicus	13-17
28665109-11	2017	Above all, this study reinforces the notion that IAPP amyloidogenesis is governed by precise intermolecular interactions involving specific Asn side chains.	Asparagine	140-143	islet amyloid polypeptide	Rattus norvegicus	49-53
28424408-5	2017	Asparagine deprivation by L-asparaginase exacerbated growth inhibition induced by glutamine starvation and autophagy blockage.	Asparagine	0-10	asparaginase and isoaspartyl peptidase 1	Homo sapiens	26-40
28336547-2	2017	We recently demonstrated that the proton-coupled oligopeptide transporter 1 (PEPT1) in the intestine is glycosylated at six asparagine residues (N50, N406, N439, N510, N515, and N532).	Asparagine	124-134	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	34-75
28446609-3	2017	Previous attempts to alter glycosylation sites in Env typically involved mutating the glycosylated asparagine residues to structurally similar glutamines or alanines.	Asparagine	99-109	endogenous retrovirus group W member 1, envelope	Homo sapiens	50-53
29299118-1	2017	L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death.	Asparagine	69-81	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
29299118-1	2017	L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death.	Asparagine	69-81	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-5
29299118-3	2017	Sensitivity to L-Asp is due to the absence of L-Asparagine synthetase (ASNS), the enzyme that catalyzes the biosynthesis of L-asparagine.	Asparagine	124-136	asparaginase and isoaspartyl peptidase 1	Homo sapiens	15-20
29299118-3	2017	Sensitivity to L-Asp is due to the absence of L-Asparagine synthetase (ASNS), the enzyme that catalyzes the biosynthesis of L-asparagine.	Asparagine	124-136	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	46-69
29299118-3	2017	Sensitivity to L-Asp is due to the absence of L-Asparagine synthetase (ASNS), the enzyme that catalyzes the biosynthesis of L-asparagine.	Asparagine	124-136	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	71-75
28336547-2	2017	We recently demonstrated that the proton-coupled oligopeptide transporter 1 (PEPT1) in the intestine is glycosylated at six asparagine residues (N50, N406, N439, N510, N515, and N532).	Asparagine	124-134	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	77-82
28352997-8	2017	N-acetyl-L-cysteine (NAC), a common antioxidant, was employed to scavenge ROS, and our results demonstrated that NAC could significantly block asparaginase-induced autophagy and attenuate asparaginase-induced cytotoxicity, indicating that intracellular ROS played a crucial role in asparagine deprivation therapy.	Asparagine	282-292	X-linked Kx blood group	Homo sapiens	21-24
28352997-8	2017	N-acetyl-L-cysteine (NAC), a common antioxidant, was employed to scavenge ROS, and our results demonstrated that NAC could significantly block asparaginase-induced autophagy and attenuate asparaginase-induced cytotoxicity, indicating that intracellular ROS played a crucial role in asparagine deprivation therapy.	Asparagine	282-292	X-linked Kx blood group	Homo sapiens	113-116
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Asparagine	102-112	caspase 3	Mus musculus	34-43
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Asparagine	102-112	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	66-71
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Asparagine	102-112	caspase 3	Mus musculus	150-159
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Asparagine	102-112	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	172-177
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Asparagine	102-112	superoxide dismutase 1, soluble	Mus musculus	205-209
28587322-6	2017	DNA sequencing revealed a novel c.1270 A&gt;G mutation in exon 6 of the FGD1 gene, which led to an amino acid conversion of asparagine to aspartic acid on codon 424 and in silico analysis indicated that this novel missense mutation was pathogenic.	Asparagine	124-134	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	72-76
28272791-5	2017	This response was stimulated by glutamine (KM of 1.57 mM), histidine, and asparagine, but not by leucine or serine, indicating activation of the SNAT3 isoform of SN.	Asparagine	74-84	solute carrier family 38, member 3	Rattus norvegicus	145-150
28467675-3	2017	Pub1 was shown to bind to ribosomes independent of eRF1 and eRF3 and to interact with the N-terminal glutamine-/asparagine-rich prion domain of eRF3 via its short C-terminal glutamine-rich tract.	Asparagine	112-122	Pub1p	Saccharomyces cerevisiae S288C	0-4
27864899-3	2017	Previous studies had indicated that N-glycosylation could occur at three asparagine residues of N-cadherin.	Asparagine	73-83	cadherin 2	Homo sapiens	96-106
27019981-1	2017	Asparaginase, which depletes asparagine and glutamine, activates amino-acid stress response.	Asparagine	29-39	asparaginase	Homo sapiens	0-12
27864899-0	2017	N-Glycosylation at Asn 402 Stabilizes N-Cadherin and Promotes Cell-Cell Adhesion of Glioma Cells.	Asparagine	19-22	cadherin 2	Homo sapiens	38-48
28521505-14	2017	Small differences in the ToF-SIMS intensities from amino acid fragments characteristic of each helical unit (Asn for alpha-1; His for alpha-2; and Phe for alpha-3) suggests either slight changes in the orientation or a slight uncovering of the alpha-1 and alpha-2 for adsorbed dhOC.	Asparagine	109-112	adrenoceptor alpha 1D	Homo sapiens	117-124
28416685-4	2017	This assay was used to screen candidate lysosomal transporters, leading to the identification of sodium-coupled neutral amino acid transporter 7 (SNAT7), encoded by the SLC38A7 gene, as a lysosomal transporter highly selective for glutamine and asparagine.	Asparagine	245-255	solute carrier family 38 member 7	Homo sapiens	146-151
28515731-6	2017	Consistently, metabolomic profiling revealed that CDF3 evokes changes in the primary metabolism triggering enhanced nitrogen assimilation, and disclosed that the amount of some protective metabolites including sucrose, GABA and asparagine were higher in vegetative tissues of CDF3 overexpressing plants.	Asparagine	228-238	cycling DOF factor 3	Arabidopsis thaliana	50-54
28416685-4	2017	This assay was used to screen candidate lysosomal transporters, leading to the identification of sodium-coupled neutral amino acid transporter 7 (SNAT7), encoded by the SLC38A7 gene, as a lysosomal transporter highly selective for glutamine and asparagine.	Asparagine	245-255	solute carrier family 38 member 7	Homo sapiens	169-176
27515058-11	2017	Introduction of asparagine at P97 of both HLA-B*7 and HLA-B*51 increased FHC expression.	Asparagine	16-26	major histocompatibility complex, class I, B	Homo sapiens	42-47
28144995-8	2017	Two mutations in HSPB8 (Lys141Met/Asn) exhibited increased binding to Bag3.	Asparagine	34-37	heat shock protein family B (small) member 8	Homo sapiens	17-22
28144995-8	2017	Two mutations in HSPB8 (Lys141Met/Asn) exhibited increased binding to Bag3.	Asparagine	34-37	BAG cochaperone 3	Homo sapiens	70-74
28426790-5	2017	Surprisingly, the additional deletion of the gene encoding endo-beta-N-acetylglucosaminidase (Engase), which is another de-N-glycosylating enzyme but leaves a single GlcNAc at glycosylated Asn residues, resulted in the partial rescue of the lethality of the Ngly1-deficient mice.	Asparagine	189-192	endo-beta-N-acetylglucosaminidase	Mus musculus	59-92
28426790-5	2017	Surprisingly, the additional deletion of the gene encoding endo-beta-N-acetylglucosaminidase (Engase), which is another de-N-glycosylating enzyme but leaves a single GlcNAc at glycosylated Asn residues, resulted in the partial rescue of the lethality of the Ngly1-deficient mice.	Asparagine	189-192	endo-beta-N-acetylglucosaminidase	Mus musculus	94-100
28064023-5	2017	The deduced primary structure of the gpGILT protein includes all of the typical features of other known GILT proteins, including an active-site motif, CXXC, a GILT signature sequence, CQHGX2ECX2NX4C, three potential Asn-linked glycosylation sites, and six other conserved cysteines.	Asparagine	216-219	gamma-interferon-inducible lysosomal thiol reductase	Cavia porcellus	39-43
28064023-5	2017	The deduced primary structure of the gpGILT protein includes all of the typical features of other known GILT proteins, including an active-site motif, CXXC, a GILT signature sequence, CQHGX2ECX2NX4C, three potential Asn-linked glycosylation sites, and six other conserved cysteines.	Asparagine	216-219	gamma-interferon-inducible lysosomal thiol reductase	Cavia porcellus	104-108
28434301-0	2017	An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.	Asparagine	10-13	beta-2-microglobulin	Homo sapiens	45-65
27515058-11	2017	Introduction of asparagine at P97 of both HLA-B*7 and HLA-B*51 increased FHC expression.	Asparagine	16-26	major histocompatibility complex, class I, B	Homo sapiens	54-59
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Asparagine	84-87	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	174-203
28245869-9	2017	L-asparaginase, an enzyme that catalyzes the hydrolysis of asparagine and glutamine to aspartic acid and glutamate, respectively, mimics the effect of glutamine withdrawal and also diminished the proportion of SP cells.	Asparagine	59-69	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27990720-2	2017	Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms.	Asparagine	81-91	neuropeptide S receptor 1	Homo sapiens	108-113
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Asparagine	84-87	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	205-208
28123394-11	2016	From these analyses, differences in the degree of metabolite accumulation between adh1 and WT were detected, including soluble sugars (e.g., sucrose) and amino acids (e.g., asparagine).	Asparagine	173-183	alcohol dehydrogenase 1	Arabidopsis thaliana	82-86
28085286-5	2017	In the crystal structure, the asparagine moiety in 17 provides additional interactions with Glu-262 from PDK2.	Asparagine	30-40	pyruvate dehydrogenase kinase, isoenzyme 2	Mus musculus	105-109
28165386-5	2017	Markedly, oxidative modifications of MNSOD were identified at histidine (H54 and H55), tyrosine (Y58), tryptophan (W147, W149, W205 and W210) and asparagine (N206 and N209) residues additional to methionine.	Asparagine	146-156	superoxide dismutase 2	Homo sapiens	37-42
28959869-4	2017	The chromophoric groups, the changes of secondary structure and the molecular docking simulations revealed that the active pocket formed by Cys281-Lys-Asn-Lys-Glu-Lys-Lys287 and Leu313-Ala-Phe-Trp316 of P.rbeta2-GPI-DV and the -COOH carboxyl of oxLig-1 were the key for binding.	Asparagine	151-154	glucose-6-phosphate isomerase	Homo sapiens	212-215
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Asparagine	386-396	superoxide dismutase 2	Homo sapiens	22-26
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Asparagine	386-396	heat shock protein family A (Hsp70) member 4	Homo sapiens	49-54
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Asparagine	386-396	superoxide dismutase 2	Homo sapiens	130-134
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Asparagine	386-396	superoxide dismutase 2	Homo sapiens	130-134
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Asparagine	386-396	superoxide dismutase 2	Homo sapiens	130-134
27997792-1	2017	Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the Asn residue in the Asn-X-Ser/Thr sequon in proteins, where X is not proline.	Asparagine	74-77	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
27997792-1	2017	Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the Asn residue in the Asn-X-Ser/Thr sequon in proteins, where X is not proline.	Asparagine	74-77	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
28045525-4	2017	The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the native Asn of AGRP or a diaminopropionic (Dap) acid residue previously shown to increase antagonist potency at the mMC4R.	Asparagine	192-195	agouti related neuropeptide	Mus musculus	102-106
28395541-5	2017	The C to G exchange (AAC&gt;AAG) at codon 108 of the beta-globin gene results in the substitution of asparagine by lysine.	Asparagine	101-111	N-methylpurine DNA glycosylase	Homo sapiens	28-31
27762090-4	2017	Wnt5b was glycosylated at three asparagine residues and lipidated at one serine residue, and these post-translational modifications of Wnt5b were essential for secretion.	Asparagine	32-42	Wnt family member 5B	Homo sapiens	0-5
27915242-4	2017	HttQ103 aggregates can induce aggregation of cellular proteins, many of which contain glutamine/asparagine-rich regions, including Sup35 and Def1.	Asparagine	96-106	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	131-136
28081948-1	2017	Given that Cav3.2 T-type Ca2+ channels were functionally regulated by asparagine (N)-linked glycosylation, we examined effects of high glucose on the function of Cav3.2, known to regulate secretory function, in neuroendocrine-like differentiated prostate cancer LNCaP cells.	Asparagine	70-80	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	11-17
28935112-2	2017	The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins.	Asparagine	161-171	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	52-77
28935112-2	2017	The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins.	Asparagine	161-171	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	79-82
28178702-0	2017	Dysregulation of the Expression of Asparagine-Linked Glycosylation 13 Short Isoform 2 Affects Nephrin Function by Altering Its N-Linked Glycosylation.	Asparagine	35-45	NPHS1 adhesion molecule, nephrin	Homo sapiens	94-101
28178702-2	2017	Recently, we identified a missense variant (p.T141L) in the short isoform 2 of the X-linked gene asparagine-linked glycosylation 13 (ALG13-is2), which segregated with focal segmental glomerulosclerosis and PCCD in a large Australian pedigree; however, any evidence of its pathogenicity was demonstrated.	Asparagine	97-107	ALG13 UDP-N-acetylglucosaminyltransferase subunit	Homo sapiens	133-138
27973834-0	2016	Experimental and Theoretical Investigations of Infrared Multiple Photon Dissociation Spectra of Asparagine Complexes with Zn2+ and Cd2+ and Their Deamidation Processes.	Asparagine	96-106	CD2 molecule	Homo sapiens	131-134
27973834-1	2016	Complexes of asparagine (Asn) cationized with Zn2+ and Cd2+ were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from a free electron laser.	Asparagine	13-23	CD2 molecule	Homo sapiens	55-58
27973834-1	2016	Complexes of asparagine (Asn) cationized with Zn2+ and Cd2+ were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from a free electron laser.	Asparagine	25-28	CD2 molecule	Homo sapiens	55-58
27880901-6	2016	However, GCN2-deficient CD8+ T cells fail to proliferate in limiting tryptophan, arginine, leucine, lysine, or asparagine, the opposite of what previous studies concluded.	Asparagine	111-121	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	9-13
27384988-11	2016	The results indicate that the Asn 165 residue of rpS3 is a critical site for N-linked glycosylation and passage through the ER-Golgi secretion pathway.	Asparagine	30-33	ribosomal protein S3	Homo sapiens	49-53
28330312-5	2016	L-Asparaginase from bacteria causes anaphylaxis and other abnormal sensitive reactions due to low specificity to asparagine.	Asparagine	113-123	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
28330312-12	2016	L-Asparaginase production by C7 was higher with glucose as carbon source and asparagine as nitrogen source.	Asparagine	77-87	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27612916-5	2016	This low-frequency variation, found in two individuals of a population of 305 healthy volunteers, leads to the translation of an asparagine instead of an aspartic acid (UGT2B7 p.D121N).	Asparagine	129-139	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	169-175
27866900-4	2016	Mass spectrometry analysis identified two asparagine residues in the helicase 2i domain of RIG-I that were deamidated upon UL37 expression or HSV-1 infection.	Asparagine	42-52	DExD/H-box helicase 58	Homo sapiens	91-96
27866900-4	2016	Mass spectrometry analysis identified two asparagine residues in the helicase 2i domain of RIG-I that were deamidated upon UL37 expression or HSV-1 infection.	Asparagine	42-52	tegument protein UL37	Human alphaherpesvirus 1	123-127
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	186-196	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	186-196	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	221-224	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	221-224	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	312-315	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Asparagine	312-315	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-7	2016	Taken together, these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface.	Asparagine	87-90	platelet and endothelial cell adhesion molecule 1	Homo sapiens	167-174
27866936-1	2016	l-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in l-aspartic acid and ammonium.	Asparagine	67-77	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27866936-5	2016	Actually, l-asparaginase catalyzes the hydrolysis of l-asparagine, not allowing the reaction of reducing sugars with this aminoacid for the generation of acrylamide.	Asparagine	53-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-24
27443449-10	2016	CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.	Asparagine	95-98	ATM serine/threonine kinase	Homo sapiens	81-84
27805378-8	2016	Mutation of these residues to Asn alters the functionality of NCKX2 because of the elimination of the favorable carboxylate-cation interactions.	Asparagine	30-33	solute carrier family 24 member 2	Homo sapiens	62-67
27582391-6	2016	Molecular dynamics simulations indicate that deglycosylation at Asn-163 of CD16 removes the steric hindrance for the CD16-hIgG1 Fc binding and thus increases the binding affinity.	Asparagine	64-67	Fc gamma receptor IIIa	Homo sapiens	75-79
27655909-4	2016	We identified three glycosylation sites at asparagine residues 251, 257 and 310 in SNAT1 protein, and that the first two are the primary sites.	Asparagine	43-53	solute carrier family 38 member 1	Homo sapiens	83-88
27909398-5	2016	Based on the importance of the Gln/Asn-rich 341-367 residue segment for efficient aggregation of endogenous TDP-43 when presented as a 12X-repeat and extensive spectroscopic and computational experiments, we recently proposed that this segment adopts a beta-hairpin structure that assembles in a parallel with a beta-turn configuration to form an amyloid-like structure.	Asparagine	35-38	TAR DNA binding protein	Homo sapiens	108-114
27582391-6	2016	Molecular dynamics simulations indicate that deglycosylation at Asn-163 of CD16 removes the steric hindrance for the CD16-hIgG1 Fc binding and thus increases the binding affinity.	Asparagine	64-67	Fc gamma receptor IIIa	Homo sapiens	117-121
27331778-2	2016	Introducing an asparagine-to-methionine (N265M) mutation at position 265 of the beta3 subunit, which sits within the etomidate-binding site, attenuates the hypnotic effect of etomidate in vivo.	Asparagine	15-25	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	80-85
26567043-2	2016	We recently developed several potent hexapeptidic agonists derived from NMU that share a common Pro-Arg-Asn-NH2 (PRN) sequence at their C-termini and found that the amide bond between Arg and Asn is rapidly degraded in serum.	Asparagine	104-107	neuromedin U	Homo sapiens	72-75
27155006-8	2016	By Sanger sequencing, we detected a homozygous single point mutation c.855T&gt;A in exon 6 of TCN2, corresponding to a asparagine (Asn) to lysine (Lys) substitution in position 267 of the mature protein.	Asparagine	119-129	transcobalamin 2	Homo sapiens	94-98
27314846-6	2016	The presence of asparaginase in the interface of bovine serum albumin (BSA) capsules showed the ability to hydrolyze the asparagine and retain the forming ammonia at the surface of the capsules.	Asparagine	121-131	albumin	Mus musculus	56-69
27155006-8	2016	By Sanger sequencing, we detected a homozygous single point mutation c.855T&gt;A in exon 6 of TCN2, corresponding to a asparagine (Asn) to lysine (Lys) substitution in position 267 of the mature protein.	Asparagine	131-134	transcobalamin 2	Homo sapiens	94-98
27796794-7	2016	However, recent data demonstrate that glycosylation of IgE at the asparagine-394 site of Cepsilon3 is necessary for IgE interaction with the high affinity IgE receptor but, surprisingly, glycosylation has no effect on IgE interaction with its low-affinity lectin receptor, CD23.	Asparagine	66-76	Fc epsilon receptor II	Homo sapiens	273-277
27561732-6	2016	The critical amino acid residues involved in forming hydrogen bonding between bisphenols and hAR is Asn 705 and Gln 711.	Asparagine	100-103	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	93-96
27687332-6	2016	For the binding of DA, Tyrosine (Tyr10) was identified as the strong binding site, and serine-asparagine-lysing (SNK(26-28)) segment was the weak binding segment.	Asparagine	94-104	polo like kinase 2	Homo sapiens	113-116
27554055-1	2016	Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells.	Asparagine	12-15	ornithine decarboxylase 1	Sus scrofa	59-62
27554055-7	2016	We found that Asn restored ODC expression that was decreased by LPS treatment.	Asparagine	14-17	ornithine decarboxylase 1	Sus scrofa	27-30
27554055-10	2016	Moreover, Asn decreased p38 phosphorylation but increased ERK1/2 phosphorylation.	Asparagine	10-13	mitogen-activated protein kinase 3	Sus scrofa	58-64
27554055-11	2016	Our results suggest that Asn improves intestinal integrity during an inflammatory insult, which appears to be related to the decrease of intestinal pro-inflammatory cytokine (via TLR4, NODs and p38) and of enterocyte apoptosis (via p38 and ERK1/2).	Asparagine	25-28	toll like receptor 4	Sus scrofa	179-183
27554055-11	2016	Our results suggest that Asn improves intestinal integrity during an inflammatory insult, which appears to be related to the decrease of intestinal pro-inflammatory cytokine (via TLR4, NODs and p38) and of enterocyte apoptosis (via p38 and ERK1/2).	Asparagine	25-28	mitogen-activated protein kinase 3	Sus scrofa	240-246
27554055-0	2016	Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge.	Asparagine	0-10	toll like receptor 4	Sus scrofa	51-55
27554055-0	2016	Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge.	Asparagine	0-10	mitogen-activated protein kinase 3	Sus scrofa	109-115
27554055-1	2016	Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells.	Asparagine	0-10	ornithine decarboxylase 1	Sus scrofa	34-57
27554055-1	2016	Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells.	Asparagine	0-10	ornithine decarboxylase 1	Sus scrofa	59-62
27554055-1	2016	Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells.	Asparagine	12-15	ornithine decarboxylase 1	Sus scrofa	34-57
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Asparagine	113-123	KRAS proto-oncogene, GTPase	Homo sapiens	269-273
27492264-3	2016	This interaction requires the presence of an asparagine-linked (N-)glycan on the Fc, and variations in the N-glycan composition can affect the affinity of CD16A binding (an FcgammaR).	Asparagine	45-55	Fc gamma receptor IIIa	Homo sapiens	155-160
27764698-5	2016	KRAS mutation causes a marked decrease in aspartate level and an increase in asparagine level in CRC.	Asparagine	77-87	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27764698-7	2016	Importantly, we demonstrated that KRAS-mutant CRC cells could become adaptive to glutamine depletion through asparagine biosynthesis by ASNS and that asparagine addition could rescue the inhibited growth and viability of cells grown under the glutamine-free condition in vitro.	Asparagine	109-119	KRAS proto-oncogene, GTPase	Homo sapiens	34-38
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Asparagine	113-123	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	136-140
27764698-7	2016	Importantly, we demonstrated that KRAS-mutant CRC cells could become adaptive to glutamine depletion through asparagine biosynthesis by ASNS and that asparagine addition could rescue the inhibited growth and viability of cells grown under the glutamine-free condition in vitro.	Asparagine	109-119	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	136-140
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Asparagine	113-123	KRAS proto-oncogene, GTPase	Homo sapiens	224-228
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Asparagine	113-123	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	238-242
27659162-3	2016	Recently, it was demonstrated that asparagine-linked glycosylation not only plays an essential role in regulating cell surface expression of Cav3.2 channels, but may also support glucose-dependent potentiation of T-type currents.	Asparagine	35-45	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	141-147
27543059-3	2016	Here, we show that deletion of edc3, when combined with a removal of the glutamine/asparagine rich region of Lsm4 (edc3Delta lsm4DeltaC) reduces mRNA stability and alters pathways of mRNA degradation.	Asparagine	83-93	U6 snRNA complex subunit LSM4	Saccharomyces cerevisiae S288C	109-113
27561782-5	2016	Moreover, transgenic lines overexpressing the site-specific mutagenesis from D27 (Asp) into E27 (Glu) in VTC1 showed enhanced AsA accumulation and reduced H2O2 content in Arabidopsis seedlings, compared with the lines overexpressing the mutation from D27 into N27 (Asn) in VTC1.	Asparagine	265-268	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	105-109
32908392-0	2016	Chicken Ovotransferrin Variants OTFB and OTFC Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity.	Asparagine	90-93	transferrin (ovotransferrin)	Gallus gallus	8-22
27543059-3	2016	Here, we show that deletion of edc3, when combined with a removal of the glutamine/asparagine rich region of Lsm4 (edc3Delta lsm4DeltaC) reduces mRNA stability and alters pathways of mRNA degradation.	Asparagine	83-93	U6 snRNA complex subunit LSM4	Saccharomyces cerevisiae S288C	125-135
27754450-4	2016	Among 32 HIV-2 ROD Env mutants tested, we demonstrated that the asparagine residue at position 659 located in the gp36 ectodomain is mandatory to exert the anti-tetherin function.	Asparagine	64-74	endogenous retrovirus group K member 20	Homo sapiens	19-22
27754450-4	2016	Among 32 HIV-2 ROD Env mutants tested, we demonstrated that the asparagine residue at position 659 located in the gp36 ectodomain is mandatory to exert the anti-tetherin function.	Asparagine	64-74	podoplanin	Homo sapiens	114-118
27754450-4	2016	Among 32 HIV-2 ROD Env mutants tested, we demonstrated that the asparagine residue at position 659 located in the gp36 ectodomain is mandatory to exert the anti-tetherin function.	Asparagine	64-74	bone marrow stromal cell antigen 2	Homo sapiens	161-169
27754450-11	2016	In HIV-2 infected cells, an efficient Env-mediated antagonism of BST-2 is operated through an intermolecular link involving the asparagine 659 residue as well as the C-terminal part of the cytoplasmic tail.	Asparagine	128-138	endogenous retrovirus group K member 20	Homo sapiens	38-41
27754450-11	2016	In HIV-2 infected cells, an efficient Env-mediated antagonism of BST-2 is operated through an intermolecular link involving the asparagine 659 residue as well as the C-terminal part of the cytoplasmic tail.	Asparagine	128-138	bone marrow stromal cell antigen 2	Homo sapiens	65-70
27547863-2	2016	According to the predicted topological structure, hPepT1 contains multiple asparagine residues in putative N-glycosylation sites.	Asparagine	75-85	solute carrier family 15 member 1	Homo sapiens	50-56
27547863-6	2016	We also constructed multiple N-glycosylation mutants based on the hPepT1-N562Q mutant by mutagenizing the additional asparagine residues N404Q, N408Q, N439Q, N509Q, and N514Q.	Asparagine	117-127	solute carrier family 15 member 1	Homo sapiens	66-72
27115710-1	2016	INTRODUCTION: Asparagine endopeptidase (AEP) is a pH-dependent endolysosomal cysteine protease that cleaves its substrates after asparagine residues.	Asparagine	129-139	legumain	Mus musculus	14-38
27572423-0	2016	Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase alpha, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.	Asparagine	0-10	AKT serine/threonine kinase 1	Homo sapiens	98-101
27572423-0	2016	Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase alpha, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.	Asparagine	0-10	toll like receptor 4	Homo sapiens	140-160
27572423-9	2016	In addition, Asn decreased muscle AMP-activated protein kinase (AMPK) alpha phosphorylation, but increased muscle protein kinase B (Akt) and Forkhead Box O (FOXO) 1 phosphorylation.	Asparagine	13-16	AKT serine/threonine kinase 1	Homo sapiens	132-135
27572423-12	2016	The beneficial effects of Asn on muscle atrophy may be associated with the following: (1) inhibiting muscle protein degradation via activating Akt and inactivating AMPKalpha and FOXO1; and (2) decreasing the expression of muscle pro-inflammatory cytokines via inhibiting TLR4 and NOD signalling pathways by modulation of their negative regulators.	Asparagine	26-29	AKT serine/threonine kinase 1	Homo sapiens	143-146
27572423-12	2016	The beneficial effects of Asn on muscle atrophy may be associated with the following: (1) inhibiting muscle protein degradation via activating Akt and inactivating AMPKalpha and FOXO1; and (2) decreasing the expression of muscle pro-inflammatory cytokines via inhibiting TLR4 and NOD signalling pathways by modulation of their negative regulators.	Asparagine	26-29	forkhead box O1	Homo sapiens	178-183
27572423-12	2016	The beneficial effects of Asn on muscle atrophy may be associated with the following: (1) inhibiting muscle protein degradation via activating Akt and inactivating AMPKalpha and FOXO1; and (2) decreasing the expression of muscle pro-inflammatory cytokines via inhibiting TLR4 and NOD signalling pathways by modulation of their negative regulators.	Asparagine	26-29	toll like receptor 4	Homo sapiens	271-275
27567024-2	2016	It is the only SOD isozyme that is secreted and glycosylated (at asparagine 89).	Asparagine	65-75	superoxide dismutase 3	Homo sapiens	15-18
27115710-1	2016	INTRODUCTION: Asparagine endopeptidase (AEP) is a pH-dependent endolysosomal cysteine protease that cleaves its substrates after asparagine residues.	Asparagine	129-139	legumain	Mus musculus	40-43
27719672-9	2016	The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates.	Asparagine	60-63	sex hormone binding globulin	Homo sapiens	71-75
27515704-3	2016	The corresponding fusion protein (F8-IL12p40), which inhibits colitis development in mice, is a glycosylated protein with suboptimal disease targeting properties in vivo Since the protein was extensively glycosylated, as evidenced by PNGase F treatment and mass spectrometric analysis, we mutated four asparagine residues in various combinations.	Asparagine	302-312	interleukin 12b	Mus musculus	37-44
27251594-1	2016	OBJECTIVE: Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine.	Asparagine	142-152	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	11-32
27251594-1	2016	OBJECTIVE: Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine.	Asparagine	142-152	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	34-38
27216773-2	2016	A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans.	Asparagine	121-131	growth factor independent 1 transcriptional repressor	Homo sapiens	57-85
27179641-5	2016	Mutagenesis showed that asparagine-N200 and aspartate-D201 inside transmembrane5 (TM5), and lysine-K355 inside TM10 are critical for AtCHX17 activity.	Asparagine	24-34	cation/H+ exchanger 17	Arabidopsis thaliana	133-140
27556810-8	2016	Mutation of this residue to the consensus asparagine (K799N) resulted in an increase in potency for tetracaine, but a decrease for TC-N 1752, suggesting that this residue can influence interaction of inhibitors with the Nav1.9 pore.	Asparagine	42-52	sodium voltage-gated channel alpha subunit 11	Homo sapiens	220-226
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Asparagine	116-119	cytochrome p450 oxidoreductase	Homo sapiens	0-25
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Asparagine	116-119	cytochrome p450 oxidoreductase	Homo sapiens	27-30
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Asparagine	116-119	cytochrome p450 oxidoreductase	Homo sapiens	132-135
27451395-7	2016	Release of active SBT3 from the autoinhibited complex relied on a pH-dependent cleavage of the propeptide at Asn-38 and Asp-54.	Asparagine	109-112	subtilisin-like protease	Solanum lycopersicum	18-22
27464742-1	2016	This study is focused on a new amide derivative of the peptide HLDF-6 (Thr-Gly-Glu-Asn-His-Arg).	Asparagine	83-86	ribosomal protein S21	Homo sapiens	63-67
27480168-2	2016	Previous work, and in silico prediction, suggest that hENT1 is glycosylated at Asn(48) in the first extracellular loop of the protein and that glycosylation plays a role in correct localization and function of hENT1.	Asparagine	79-82	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	54-59
27339896-3	2016	We document that RCL-localized Asn(347) glycosylation fine-tunes the RCL cleavage rate by human neutrophil elastase (NE) and Pseudomonas aeruginosa elastase (PAE) by different mechanisms.	Asparagine	31-34	elastase, neutrophil expressed	Homo sapiens	96-115
27339896-3	2016	We document that RCL-localized Asn(347) glycosylation fine-tunes the RCL cleavage rate by human neutrophil elastase (NE) and Pseudomonas aeruginosa elastase (PAE) by different mechanisms.	Asparagine	31-34	elastase, neutrophil expressed	Homo sapiens	117-119
27519525-6	2016	In long-lived proteins, L-Asp and L-Asn can racemize to three other isomers, D-isoAsp, L-isoAsp and D-Asp and this is significant because isoAsp formation in peptides renders them immunogenic.Proteomic analysis revealed widespread modifications of MBP with two surface regions that are altered in MS.	Asparagine	34-39	myelin basic protein	Homo sapiens	248-251
27380309-7	2016	Most other HKT1 sequences, including AtHKT1, contain Asn (N) in this position.	Asparagine	53-56	high-affinity K+ transporter 1	Arabidopsis thaliana	11-15
27380309-7	2016	Most other HKT1 sequences, including AtHKT1, contain Asn (N) in this position.	Asparagine	53-56	high-affinity K+ transporter 1	Arabidopsis thaliana	37-43
27380309-9	2016	We suggest that the presence of Asn or Asp is the essential feature that defines and establishes cation selectivity in dicot HKT1-type transporters.	Asparagine	32-35	high-affinity K+ transporter 1	Arabidopsis thaliana	125-129
27216773-2	2016	A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans.	Asparagine	121-131	growth factor independent 1 transcriptional repressor	Homo sapiens	87-91
27216773-2	2016	A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans.	Asparagine	121-131	growth factor independent 1 transcriptional repressor	Homo sapiens	148-152
27216773-2	2016	A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans.	Asparagine	121-131	growth factor independent 1 transcriptional repressor	Homo sapiens	148-152
27240426-0	2016	Hb Tarrant [alpha126(H9)Asp Asn; HBA2: c.379G &gt; A (or HBA1)] in a Chinese Family as a Cause of Familial Erythrocytosis.	Asparagine	28-31	hemoglobin subunit alpha 2	Homo sapiens	33-37
26300286-6	2016	From the QSAR properties, amino acids such as asparagine and aspartic acids are the major reactive sites in the Zif268 protein.	Asparagine	46-56	early growth response 1	Homo sapiens	112-118
27307044-7	2016	In SLC30A10, the corresponding residues are Asn-43 and Asp-47 in the second and His-244 and Asp-248 in the fifth transmembrane segments.	Asparagine	44-47	solute carrier family 30 member 10	Homo sapiens	3-11
27363609-1	2016	The GTP hydrolysis activities of Rho GTPases are stimulated by GTPase-activating proteins (GAPs), which contain a RhoGAP domain equipped with a characteristic arginine finger and an auxiliary asparagine for catalysis.	Asparagine	192-202	Rho GTPase activating protein 1	Homo sapiens	114-120
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	Rho GTPase activating protein 1	Homo sapiens	52-58
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	myosin IXB	Homo sapiens	69-74
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	myosin IXB	Homo sapiens	76-81
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	Rho GTPase activating protein 1	Homo sapiens	82-88
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	Rho GTPase activating protein 1	Homo sapiens	82-88
27363609-2	2016	However, the auxiliary asparagine is missing in the RhoGAP domain of Myo9b (Myo9b-RhoGAP), a unique motorized RhoGAP that specifically targets RhoA for controlling cell motility.	Asparagine	23-33	ras homolog family member A	Homo sapiens	143-147
27363609-7	2016	Our data indicate that Myo9b-RhoGAP accelerates RhoA GTP hydrolysis by a previously unknown dual-arginine-finger mechanism, which may be shared by other noncanonical RhoGAP domains lacking the auxiliary asparagine.	Asparagine	203-213	myosin IXB	Homo sapiens	23-28
27363609-7	2016	Our data indicate that Myo9b-RhoGAP accelerates RhoA GTP hydrolysis by a previously unknown dual-arginine-finger mechanism, which may be shared by other noncanonical RhoGAP domains lacking the auxiliary asparagine.	Asparagine	203-213	Rho GTPase activating protein 1	Homo sapiens	29-35
27363609-7	2016	Our data indicate that Myo9b-RhoGAP accelerates RhoA GTP hydrolysis by a previously unknown dual-arginine-finger mechanism, which may be shared by other noncanonical RhoGAP domains lacking the auxiliary asparagine.	Asparagine	203-213	ras homolog family member A	Homo sapiens	48-52
27363609-7	2016	Our data indicate that Myo9b-RhoGAP accelerates RhoA GTP hydrolysis by a previously unknown dual-arginine-finger mechanism, which may be shared by other noncanonical RhoGAP domains lacking the auxiliary asparagine.	Asparagine	203-213	Rho GTPase activating protein 1	Homo sapiens	166-172
27363609-5	2016	The first arginine finger resembles the one within the canonical RhoGAP domains and inserts into the nucleotide-binding pocket of RhoA, whereas the second arginine finger anchors the Switch I loop of RhoA and interacts with the nucleotide, stabilizing the transition state of GTP hydrolysis and compensating for the lack of the asparagine.	Asparagine	328-338	Rho GTPase activating protein 1	Homo sapiens	65-71
27363609-5	2016	The first arginine finger resembles the one within the canonical RhoGAP domains and inserts into the nucleotide-binding pocket of RhoA, whereas the second arginine finger anchors the Switch I loop of RhoA and interacts with the nucleotide, stabilizing the transition state of GTP hydrolysis and compensating for the lack of the asparagine.	Asparagine	328-338	ras homolog family member A	Homo sapiens	130-134
27033522-8	2016	Mass spectrometry detected asparagine (N)-glycosylation on the secreted PEBP4.	Asparagine	27-37	phosphatidylethanolamine binding protein 4	Homo sapiens	72-77
27363609-5	2016	The first arginine finger resembles the one within the canonical RhoGAP domains and inserts into the nucleotide-binding pocket of RhoA, whereas the second arginine finger anchors the Switch I loop of RhoA and interacts with the nucleotide, stabilizing the transition state of GTP hydrolysis and compensating for the lack of the asparagine.	Asparagine	328-338	ras homolog family member A	Homo sapiens	200-204
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Asparagine	119-122	solute carrier family 30 member 10	Homo sapiens	52-58
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Asparagine	119-122	solute carrier family 30 member 1	Homo sapiens	52-57
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Asparagine	119-122	solute carrier family 30 member 10	Homo sapiens	281-287
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Asparagine	119-122	solute carrier family 30 member 10	Homo sapiens	281-287
27189945-5	2016	The DeltaGly-141 and DeltaG141/E142N mutants were inactive with cytochrome P450 but fully active in reducing cytochrome c In the DeltaGly-141 mutants, the backbone amide of Glu/Asn-142 forms an H-bond to the N5 of the oxidized flavin, which leads to formation of an unstable red anionic semiquinone with a more negative potential than the hydroquinone.	Asparagine	177-180	cytochrome c, somatic	Homo sapiens	109-121
27353444-0	2016	Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.	Asparagine	32-35	gap junction protein beta 2	Homo sapiens	82-86
27080012-3	2016	A single-nucleotide polymorphism of GFI1 (rs34631763) generates a protein with an asparagine (N) instead of a serine (S) at position 36 (GFI1(36N)) and has a prevalence of 3%-5% among Caucasians.	Asparagine	82-92	growth factor independent 1 transcriptional repressor	Homo sapiens	36-40
27080012-3	2016	A single-nucleotide polymorphism of GFI1 (rs34631763) generates a protein with an asparagine (N) instead of a serine (S) at position 36 (GFI1(36N)) and has a prevalence of 3%-5% among Caucasians.	Asparagine	82-92	growth factor independent 1 transcriptional repressor	Homo sapiens	137-141
27189942-0	2016	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	Asparagine	78-88	epidermal growth factor receptor pathway substrate 15	Homo sapiens	127-132
27356208-6	2016	With this aim, the first 45 residues of mature hFIX were explored to find out suitable positions for introducing either Asn or Ser/Thr residues, to create new N-glycosylation site(s).	Asparagine	120-123	coagulation factor IX	Homo sapiens	47-51
27246700-3	2016	Alpha-1-acid glycoprotein (A1AG) and serotransferrin (Tf) were observed for the first time to be N-glycosylated on asparagine residues within a total of six unique noncanonical motifs.	Asparagine	115-125	transferrin	Homo sapiens	37-52
27208305-5	2016	Two additional T salsuginea and most other HKT1 sequences contain Asn (n) in this position.	Asparagine	66-69	high-affinity K+ transporter 1	Arabidopsis thaliana	43-47
27208305-9	2016	Thus, the introduction of Asp, replacing Asn, in HKT1-type transporters established altered cation selectivity and uptake dynamics.	Asparagine	41-44	high-affinity K+ transporter 1	Arabidopsis thaliana	49-53
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Asparagine	9-19	reticulon 4 receptor	Mus musculus	4-7
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Asparagine	9-19	alanyl (membrane) aminopeptidase	Mus musculus	83-87
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Asparagine	9-19	alanyl (membrane) aminopeptidase	Mus musculus	89-105
27068744-6	2016	A conserved CTE asparagine residue is required for ubiquitylation and degradation of a subset of Doa10 substrates.	Asparagine	16-26	E3 ubiquitin-protein ligase SSM4	Saccharomyces cerevisiae S288C	97-102
27274076-8	2016	Furthermore, we identified two conserved asparagines in MTN1 and MTN2 from Arabidopsis that confer loss of function phenotypes when deamidated via site-specific mutation.	Asparagine	41-52	methylthioadenosine nucleosidase 1	Arabidopsis thaliana	56-60
27274076-8	2016	Furthermore, we identified two conserved asparagines in MTN1 and MTN2 from Arabidopsis that confer loss of function phenotypes when deamidated via site-specific mutation.	Asparagine	41-52	Phosphorylase superfamily protein	Arabidopsis thaliana	65-69
27106100-4	2016	ASRGL1 encodes an enzyme that catalyzes the hydrolysis of L-asparagine and isoaspartyl-peptides.	Asparagine	58-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-6
27106526-4	2016	Herein, utilizing the dual stimulus of hyperthermia and the intracellular redox environment, we devised a thermosensitive liposome (TSL) containing an Asparagine-Glycine-Arginine (NGR) peptide and reducible siRNA-CPPs for tumor-specific siRNA transfection (siRNA-CPPs/NGR-TSL), in which siRNA-CPPs were "caged" in NGR-TSL to overcome their limitations in vivo.	Asparagine	151-161	reticulon 4 receptor	Homo sapiens	180-183
27068744-9	2016	Mutation of the conserved Asn residue (N890A) in the MARCH6 CTE stabilized the normally short lived enzyme to the same degree as a catalytically inactivating mutation (C9A).	Asparagine	26-29	membrane associated ring-CH-type finger 6	Homo sapiens	53-59
26797250-3	2016	Cleavage of the peptide substrate (ESENCRK-FITC) after asparagine residue by VPE resulted in the 2-cyano-6-amino-benzothiazole (CABT)-functionalized magnetic beads capture of the severed substrate CRK-FITC via a condensation reaction between CABT and cysteine (Cys).	Asparagine	55-65	CRK proto-oncogene, adaptor protein	Homo sapiens	39-42
27026706-5	2016	Remarkably, a tryptophan that anchors ligands in mammalian CBG steroid-binding sites is replaced by an asparagine.	Asparagine	103-113	serpin family A member 6	Rattus norvegicus	59-62
27026706-7	2016	Glycosylation of this asparagine in zebra finch CBG does not influence its steroid-binding affinity, but we present evidence that it may participate in protein folding and steroid-binding site formation.	Asparagine	22-32	serpin family A member 6	Rattus norvegicus	48-51
26655179-7	2016	The three strategies involved immobilization of Anti-CA125 antibody - (1) after EDC-NHS activation of citrate stabilized gold nanoparticles, (2) directly onto citrate stabilized gold nanoparticles and (3) directly onto L-Asparagine stabilized gold nanoparticles modified electrode surfaces.	Asparagine	219-231	mucin 16, cell surface associated	Homo sapiens	53-58
25858017-3	2016	Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine, and its expression is associated with the chemotherapy resistance and prognosis in several human cancers.	Asparagine	131-141	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
25858017-3	2016	Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine, and its expression is associated with the chemotherapy resistance and prognosis in several human cancers.	Asparagine	131-141	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
27148850-15	2016	Aspartate and asparagine were identified as well-connected hubs in post-ERCP serum networks of cases and were correlated with aspartate transaminase (AST) and white blood cell count levels.	Asparagine	14-24	solute carrier family 17 member 5	Homo sapiens	126-148
27148850-15	2016	Aspartate and asparagine were identified as well-connected hubs in post-ERCP serum networks of cases and were correlated with aspartate transaminase (AST) and white blood cell count levels.	Asparagine	14-24	solute carrier family 17 member 5	Homo sapiens	150-153
27126896-5	2016	Through its exchange factor role, asparagine regulates mTORC1 activity and protein synthesis.	Asparagine	34-44	CREB regulated transcription coactivator 1	Mus musculus	55-61
26964672-4	2016	Modeling study indicated that the selectivity of our compounds to hMAO-B is determined by at least two residues, i.e., Ile 199 and Cys 172 (or corresponded Phe 208 and Asn 181 of hMAO-A).	Asparagine	168-171	monoamine oxidase B	Homo sapiens	66-72
26964672-4	2016	Modeling study indicated that the selectivity of our compounds to hMAO-B is determined by at least two residues, i.e., Ile 199 and Cys 172 (or corresponded Phe 208 and Asn 181 of hMAO-A).	Asparagine	168-171	monoamine oxidase A	Homo sapiens	179-185
27058169-7	2016	The HAESA co-receptor SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in IDA.	Asparagine	165-168	mitogen-activated protein kinase kinase 4	Homo sapiens	22-27
26944735-11	2016	Further, we report a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain.	Asparagine	65-68	bone morphogenetic protein 1	Homo sapiens	119-124
26780704-8	2016	When the sites in the interface is saturated, SDS interacts with VAL 73, HIS 74, ASN 147 and PHE 152, the key residues of the enzyme activity, and leads to the decrease of CAT activity.	Asparagine	81-84	catalase	Mus musculus	172-175
27293098-0	2016	A Glutamine/Asparagine-Rich Fragment of Gln3, but not the Full-Length Protein, Aggregates in Saccharomyces cerevisiae.	Asparagine	12-22	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	40-44
26828122-5	2016	Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416).	Asparagine	84-87	solute carrier family 44 member 4	Homo sapiens	17-22
26828122-5	2016	Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416).	Asparagine	93-96	solute carrier family 44 member 4	Homo sapiens	17-22
26828122-5	2016	Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416).	Asparagine	93-96	solute carrier family 44 member 4	Homo sapiens	17-22
27293098-1	2016	The amino acid sequence of protein Gln3 in yeast Saccharomyces cerevisiae has a region enriched with Gln (Q) and Asn (N) residues.	Asparagine	113-116	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	35-39
26828122-5	2016	Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416).	Asparagine	93-96	solute carrier family 44 member 4	Homo sapiens	17-22
26709988-6	2016	Consequently, two peptide hydroxamates Hxm-Phe-Ser-Asn and Hxm-Phe-Arg-Gln were found to exhibit potent inhibition against ADAM17 (Ki=92 and 47nM, respectively) and strong selectivity for ADAM17 over ADAM10 (~7-fold and ~5-fold, S=0.86 and 0.71, respectively).	Asparagine	51-54	ADAM metallopeptidase domain 17	Homo sapiens	123-129
26828122-5	2016	Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416).	Asparagine	93-96	solute carrier family 44 member 4	Homo sapiens	17-22
26709988-6	2016	Consequently, two peptide hydroxamates Hxm-Phe-Ser-Asn and Hxm-Phe-Arg-Gln were found to exhibit potent inhibition against ADAM17 (Ki=92 and 47nM, respectively) and strong selectivity for ADAM17 over ADAM10 (~7-fold and ~5-fold, S=0.86 and 0.71, respectively).	Asparagine	51-54	ADAM metallopeptidase domain 17	Homo sapiens	188-194
26709988-6	2016	Consequently, two peptide hydroxamates Hxm-Phe-Ser-Asn and Hxm-Phe-Arg-Gln were found to exhibit potent inhibition against ADAM17 (Ki=92 and 47nM, respectively) and strong selectivity for ADAM17 over ADAM10 (~7-fold and ~5-fold, S=0.86 and 0.71, respectively).	Asparagine	51-54	ADAM metallopeptidase domain 10	Homo sapiens	200-206
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Asparagine	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
26628609-1	2016	Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.	Asparagine	63-73	hypothetical protein	Arabidopsis thaliana	103-123
26628609-1	2016	Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.	Asparagine	63-73	hypothetical protein	Arabidopsis thaliana	125-127
26628609-1	2016	Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.	Asparagine	63-73	glutamate synthase 1	Arabidopsis thaliana	130-148
26628609-1	2016	Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.	Asparagine	63-73	aspartate aminotransferase	Arabidopsis thaliana	158-184
26628609-1	2016	Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.	Asparagine	63-73	aspartate aminotransferase	Arabidopsis thaliana	186-191
27043630-1	2016	Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety from the co-substrate nicotinamide adenine dinucleotide (NAD) to asparagine-41 of Rho-GTPases.	Asparagine	242-252	transforming protein RhoA	Cricetulus griseus	111-115
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Asparagine	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-7	2016	Formation of MLL" and ML2L" species was confirmed for asparagine and aspartic acid.	Asparagine	54-64	lysine methyltransferase 2A	Homo sapiens	13-16
26797122-9	2016	The critical role for possible hydrogen bond interaction at apoA-I Tyr(166) was further supported using reconstituted HDL generated from apoA-I mutants (Tyr(166)   Glu or Asn), which showed preservation in both LCAT binding affinity and catalytic efficiency.	Asparagine	171-174	apolipoprotein A1	Homo sapiens	60-66
27031502-4	2016	Expression and analysis of the suspected mutant verified the presence of asparagine in the probe-labeled, active-site peptide for CSNK1A1.	Asparagine	73-83	casein kinase 1 alpha 1	Homo sapiens	130-137
26189796-0	2016	Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.	Asparagine	50-53	cadherin 1	Homo sapiens	11-21
26189796-6	2016	Interestingly, manipulating this site-specific glycosylation, by preventing Asn-554 from receiving the deleterious branched structures, either by a mutation or by silencing GnT-V, resulted in a protective effect on E-cadherin, precluding its functional dysregulation and contributing to tumor suppression.	Asparagine	76-79	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	173-178
26189796-6	2016	Interestingly, manipulating this site-specific glycosylation, by preventing Asn-554 from receiving the deleterious branched structures, either by a mutation or by silencing GnT-V, resulted in a protective effect on E-cadherin, precluding its functional dysregulation and contributing to tumor suppression.	Asparagine	76-79	cadherin 1	Homo sapiens	215-225
26645482-3	2016	The Grb2 SH2 domain binds to its targets by recognizing a phosphotyrosine (pY) in a pYxNx peptide motif, requiring an Asn at the +2 position C-terminal to the pY with the residue either side of this Asn being hydrophobic.	Asparagine	118-121	growth factor receptor bound protein 2	Homo sapiens	4-8
26713889-4	2016	Structural, biochemical, and computational analyses of an asparagine mutation in the lysine methyltransferase SET7/9 that abolishes AdoMet S   O chalcogen bonding reveal that this interaction enhances substrate binding affinity relative to the product S-adenosylhomocysteine.	Asparagine	58-68	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	110-116
26554858-4	2016	For the recognition of asparagine and lysine, asparaginyl-tRNA synthetase and lysyl-tRNA synthase were immobilized onto microparticles, respectively, and coupled with coloration reagents for spectrophotometric detection.	Asparagine	23-33	asparaginyl-tRNA synthetase 1	Homo sapiens	46-73
26800871-8	2016	In contrast, substitution of p5M to a conventional asparagine abolished recognition by the H-2D(b)/Trh4-specific T cell clone LnB5.	Asparagine	51-61	ceramide synthase 5	Homo sapiens	99-103
26781306-8	2016	One novel non-synonymous mutation (Asn to Lys) in CYP2C19 was identified, and this mutation was predicted to be intolerant and benign by SIFT and PolyPhen-2, respectively.	Asparagine	35-38	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	50-57
26645482-3	2016	The Grb2 SH2 domain binds to its targets by recognizing a phosphotyrosine (pY) in a pYxNx peptide motif, requiring an Asn at the +2 position C-terminal to the pY with the residue either side of this Asn being hydrophobic.	Asparagine	199-202	growth factor receptor bound protein 2	Homo sapiens	4-8
26780688-1	2016	The human asparaginase-like protein 1 (hASRGL1) is a member of the N-terminal nucleophile (Ntn) family that hydrolyzes l-asparagine and isoaspartyl-dipeptides.	Asparagine	119-131	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-37
26820533-5	2016	Among the sequentially truncated CLR C-tail mutants, those lacking the five residues 449-453 (Ser-Phe-Ser-Asn-Ser) abolished the inhibition of the cell surface expression of CLR via the overexpression of GRK4 or GRK5.	Asparagine	106-109	doublecortin like kinase 3	Homo sapiens	33-36
26820533-5	2016	Among the sequentially truncated CLR C-tail mutants, those lacking the five residues 449-453 (Ser-Phe-Ser-Asn-Ser) abolished the inhibition of the cell surface expression of CLR via the overexpression of GRK4 or GRK5.	Asparagine	106-109	doublecortin like kinase 3	Homo sapiens	174-177
26820533-5	2016	Among the sequentially truncated CLR C-tail mutants, those lacking the five residues 449-453 (Ser-Phe-Ser-Asn-Ser) abolished the inhibition of the cell surface expression of CLR via the overexpression of GRK4 or GRK5.	Asparagine	106-109	G protein-coupled receptor kinase 4	Homo sapiens	204-208
26820533-5	2016	Among the sequentially truncated CLR C-tail mutants, those lacking the five residues 449-453 (Ser-Phe-Ser-Asn-Ser) abolished the inhibition of the cell surface expression of CLR via the overexpression of GRK4 or GRK5.	Asparagine	106-109	G protein-coupled receptor kinase 5	Homo sapiens	212-216
26415896-7	2016	Application to the intrinsically disordered protein alpha-synuclein shows that while most residues have close-to-zero positive phi angle populations, up to 16% positive phi population is observed for Asn residues.	Asparagine	200-203	synuclein alpha	Homo sapiens	52-67
26878238-7	2016	Notably, treatment with L-asparaginase elicited both specific diricore signals at asparagine codons and high levels of asparagine synthetase (ASNS).	Asparagine	82-92	asparaginase and isoaspartyl peptidase 1	Homo sapiens	24-38
26878238-9	2016	As for asparagine, this observation was linked to high levels of PYCR1, a key enzyme in proline production, suggesting a compensatory mechanism allowing tumour expansion.	Asparagine	7-17	pyrroline-5-carboxylate reductase 1	Homo sapiens	65-70
26901320-11	2016	More importantly, we show that the binding of Leg1a to FGFR relies on the glycosylation at the 70th asparagine (Asn(70) or N(70)), and mutating the Asn(70) to Ala(70) compromised Leg1"s function in liver development.	Asparagine	100-110	liver-enriched gene 1, tandem duplicate 1	Danio rerio	46-51
26901320-11	2016	More importantly, we show that the binding of Leg1a to FGFR relies on the glycosylation at the 70th asparagine (Asn(70) or N(70)), and mutating the Asn(70) to Ala(70) compromised Leg1"s function in liver development.	Asparagine	100-110	liver-enriched gene 1, tandem duplicate 1	Danio rerio	46-50
26901320-11	2016	More importantly, we show that the binding of Leg1a to FGFR relies on the glycosylation at the 70th asparagine (Asn(70) or N(70)), and mutating the Asn(70) to Ala(70) compromised Leg1"s function in liver development.	Asparagine	112-115	liver-enriched gene 1, tandem duplicate 1	Danio rerio	46-51
26901320-11	2016	More importantly, we show that the binding of Leg1a to FGFR relies on the glycosylation at the 70th asparagine (Asn(70) or N(70)), and mutating the Asn(70) to Ala(70) compromised Leg1"s function in liver development.	Asparagine	112-115	liver-enriched gene 1, tandem duplicate 1	Danio rerio	46-50
26773413-0	2016	Tyrosinase versus Catechol Oxidase: One Asparagine Makes the Difference.	Asparagine	40-50	tyrosinase	Homo sapiens	0-10
26773413-5	2016	Here we demonstrate for the first time that a polyphenoloxidase, which exhibits only diphenolase activity, can be transformed to a tyrosinase by mutation to introduce an asparagine.	Asparagine	170-180	tyrosinase	Homo sapiens	131-141
26780688-1	2016	The human asparaginase-like protein 1 (hASRGL1) is a member of the N-terminal nucleophile (Ntn) family that hydrolyzes l-asparagine and isoaspartyl-dipeptides.	Asparagine	119-131	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-46
26537754-13	2016	These data highlight the important role of the N-glycan Asn(575) and the C-terminal disulfide loop of rBAT in biogenesis of the rBAT-b(0,+)AT heterodimer.	Asparagine	56-59	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	128-132
26601942-5	2016	We find that VH expression and solubility are strongly enhanced by introducing multiple negatively charged or asparagine residues at the edges of CDR3, whereas other polar mutations are less effective (glutamine and serine) or ineffective (threonine, lysine, and arginine).	Asparagine	110-120	CDR3	Homo sapiens	146-150
26833727-6	2016	The consensus C:G base pairs H-bond with conserved His or Arg residues in ZnF8, ZnF9, and ZnF11, and the consensus T:A base pair H-bonds with an Asn that replaces His in ZnF10.	Asparagine	145-148	zinc finger protein 10	Homo sapiens	170-175
26611529-1	2016	NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues are converted to aspartates.	Asparagine	213-223	N-glycanase 1	Homo sapiens	0-5
26611529-1	2016	NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues are converted to aspartates.	Asparagine	213-223	N-glycanase 1	Homo sapiens	6-11
26620556-11	2016	Conversely, S-6 a hydrophobic peptide of NSP, lacking Arg or Arg-Asn with -4 charge, induced early thrombosis and mortality.	Asparagine	65-68	serpin family I member 1	Homo sapiens	41-44
26627830-0	2016	His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.	Asparagine	67-77	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	101-124
26627830-2	2016	To map the inactive and active dimeric orientations of the TM helices, we performed asparagine (Asn)-scanning mutagenesis of the TM domains of the murine and human TpoR.	Asparagine	96-99	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	164-168
26837600-5	2016	Furthermore, the distance between D21 and its possible counterpart D433 (located on the T1R2 protomer of the receptor) is safely large to avoid electrostatic repulsion but, at the same time, amenable to a closer approach if D21 is mutated into the corresponding asparagine.	Asparagine	262-272	taste 1 receptor member 2	Homo sapiens	88-92
26537754-13	2016	These data highlight the important role of the N-glycan Asn(575) and the C-terminal disulfide loop of rBAT in biogenesis of the rBAT-b(0,+)AT heterodimer.	Asparagine	56-59	solute carrier family 7 member 9	Homo sapiens	133-141
26810281-2	2016	We have found a 148G-A transition in the GJB2 gene, resulting in an asp50-to-asn (D50N) substitution in a girl with congenital deafness.	Asparagine	77-80	gap junction protein beta 2	Homo sapiens	41-45
26497246-4	2016	We show that L-asparagine is a nutrient important for T cell activation and that L-asparagine deprivation, such as that mediated by the Salmonella Typhimurium L-asparaginase, causes suppression of activation-induced mammalian target of rapamycin signaling, autophagy, Myc expression, and L-lactate secretion.	Asparagine	13-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	268-271
26497246-4	2016	We show that L-asparagine is a nutrient important for T cell activation and that L-asparagine deprivation, such as that mediated by the Salmonella Typhimurium L-asparaginase, causes suppression of activation-induced mammalian target of rapamycin signaling, autophagy, Myc expression, and L-lactate secretion.	Asparagine	81-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	268-271
26644523-10	2016	Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N).	Asparagine	199-202	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	67-70
26694855-5	2016	Several of the substitutions found in pufferfish IAPP are nonconservative including Ser to Pro, Asn to Thr, Ala to Tyr, and Leu to Tyr replacements, and several of these have not been reported in mammalian IAPP sequences.	Asparagine	96-99	islet amyloid polypeptide	Homo sapiens	49-53
27452168-1	2016	l-Asparaginase, an enzyme that catalyzes l-asparagine into aspartic acid and ammonia, has relevant applications in the pharmaceutical and food industry.	Asparagine	41-53	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26585416-6	2016	Replacement of six asparagine residues (N) at positions N50, N406, N439, N510, N515, and N532 by glutamine (Q) resulted in a decrease of the mPEPT1 mass by around 35 kDa.	Asparagine	19-29	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	141-147
27452168-4	2016	The concentration of acrylamide in food can be reduced by deamination of asparagine using l-Asparaginase.	Asparagine	73-83	asparaginase and isoaspartyl peptidase 1	Homo sapiens	90-104
27770857-1	2016	l-Asparaginase (EC 3.5.1.1) is an enzyme that catalyzes the hydrolysis of l-asparagine to l-aspartic acid.	Asparagine	74-86	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26467158-8	2016	Point mutations at two N-glycosylation sites (Asn(153) and Asn(223)) abolish the bisecting GlcNAc modification on BACE1.	Asparagine	46-49	beta-site APP cleaving enzyme 1	Mus musculus	114-119
26467158-8	2016	Point mutations at two N-glycosylation sites (Asn(153) and Asn(223)) abolish the bisecting GlcNAc modification on BACE1.	Asparagine	59-62	beta-site APP cleaving enzyme 1	Mus musculus	114-119
26745591-0	2016	Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation.	Asparagine	60-70	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	14-20
26511319-0	2015	Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible Reaction.	Asparagine	0-3	5'-aminolevulinate synthase 1	Homo sapiens	28-54
26672444-1	2016	L-Asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia.	Asparagine	16-28	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26176270-2	2016	Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX was temporally masked; local ultrasound stimulation could trigger the CPP-DOX release from NB and activate its penetration.	Asparagine	67-77	reticulon 4 receptor	Homo sapiens	96-99
26176270-2	2016	Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX was temporally masked; local ultrasound stimulation could trigger the CPP-DOX release from NB and activate its penetration.	Asparagine	67-77	reticulon 4 receptor	Homo sapiens	130-133
26358403-6	2016	The substitution of a proline at site 30 by an asparagine, an evolutionarily conserved functional residue in the scorpion alpha-KTx family, led to an increased activity on rKv1.2 and rKv1.3 but a decreased activity on the Shaker channel without changing the potency on rKv1.1, suggesting a key role of this site in species selectivity of scorpion toxins.	Asparagine	47-57	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	269-275
26239197-1	2016	l-asparaginase (ASNase), a key component in the treatment of childhood acute lymphoblastic leukemia (ALL), hydrolyzes plasma asparagine and glutamine and thereby disturbs metabolic homeostasis of leukemic cells.	Asparagine	125-135	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26239197-1	2016	l-asparaginase (ASNase), a key component in the treatment of childhood acute lymphoblastic leukemia (ALL), hydrolyzes plasma asparagine and glutamine and thereby disturbs metabolic homeostasis of leukemic cells.	Asparagine	125-135	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
26648553-4	2016	Mass spectrometric analysis revealed that the replacement of an aspartate residue with asparagine at amino acid position 120 was the biochemical difference between the two Ndufa10 isoforms.	Asparagine	87-97	NADH:ubiquinone oxidoreductase subunit A10	Rattus norvegicus	172-179
26511319-2	2015	Apart from coordinating the positioning of succinyl-CoA, Rhodobacter capsulatus ALAS Asn-85 has a proposed role in regulating the opening of an active site channel.	Asparagine	85-88	aminolevulinic acid synthase 1	Mus musculus	80-84
26673834-3	2015	Here, we observed that non-toxic polymers of various proteins with glutamine-rich domains could seed polymerization of Htt25Q, which caused toxicity by seeding polymerization of the glutamine/asparagine-rich Sup35 protein thus depleting the soluble pools of this protein and its interacting partner, Sup45.	Asparagine	192-202	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	208-213
26964218-6	2015	By analyzing the assignations of the SERS bands, it found that the content of asparagine, tyrosine and phenylalanine in the hemoglobin are significantly lower than healthy people.	Asparagine	78-88	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	37-41
26636939-5	2015	Even though substitutions for the Asn in DIV-S6 in NaV1.5, N1764A and N1764C, produce little ionic current in transfected mammalian cells, they both express robust gating currents.	Asparagine	34-37	sodium voltage-gated channel alpha subunit 5	Homo sapiens	51-57
26362868-10	2015	Furthermore, the amounts of mature type asparagine-linked (N)-glycans in ST3G5 R2A/R3A and K9A/K13A mutants were decreased compared with those in wild-type proteins, and the stability of the mutants was lower.	Asparagine	40-50	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	73-78
26367528-2	2015	Neuroserpin is a glycoprotein with predicted glycosylation sites at asparagines 157, 321 and 401.	Asparagine	68-79	serpin family I member 1	Homo sapiens	0-11
26367528-5	2015	Asparagine residue 401 is not glycosylated in wild type neuroserpin and in several polymerogenic variants that cause FENIB, but partial glycosylation was observed in the G392E mutant of neuroserpin that causes severe, early-onset dementia.	Asparagine	0-10	serpin family I member 1	Homo sapiens	186-197
26331698-7	2015	The action of L-ASNase differs between Jurkat cells and NK-cell lymphoma cells, according to their dependence on Gln and Asn.	Asparagine	121-124	asparaginase and isoaspartyl peptidase 1	Homo sapiens	14-22
26462467-3	2015	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	annexin A2	Bos taurus	42-52
26462467-3	2015	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	legumain	Bos taurus	92-100
26462467-3	2015	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	annexin A2	Bos taurus	134-144
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Asparagine	56-59	melanocortin 4 receptor	Rattus norvegicus	183-206
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Asparagine	56-59	melanocortin 4 receptor	Rattus norvegicus	208-211
26124006-11	2015	Further, there were significant differences in PFS between patients with combined C/C genotype of BAG-1 codon 324, Lys/Lys genotype of XPD codon 751, and Asp/Asp genotype of XPD codon 312 and patients carrying BAG-1 codon 324 C/T genotype, XPD codon751 Lys/Gln genotype, and XPD codon312 Asp/Asn genotype (P &lt; 0.05).	Asparagine	292-295	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	174-177
26124006-11	2015	Further, there were significant differences in PFS between patients with combined C/C genotype of BAG-1 codon 324, Lys/Lys genotype of XPD codon 751, and Asp/Asp genotype of XPD codon 312 and patients carrying BAG-1 codon 324 C/T genotype, XPD codon751 Lys/Gln genotype, and XPD codon312 Asp/Asn genotype (P &lt; 0.05).	Asparagine	292-295	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	174-177
26124006-11	2015	Further, there were significant differences in PFS between patients with combined C/C genotype of BAG-1 codon 324, Lys/Lys genotype of XPD codon 751, and Asp/Asp genotype of XPD codon 312 and patients carrying BAG-1 codon 324 C/T genotype, XPD codon751 Lys/Gln genotype, and XPD codon312 Asp/Asn genotype (P &lt; 0.05).	Asparagine	292-295	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	174-177
26552706-5	2015	Cytotoxicity and cytokine production triggered by DNAM-1 were mediated via a conserved tyrosine- and asparagine-based motif in the cytoplasmic domain of DNAM-1.	Asparagine	101-111	CD226 molecule	Homo sapiens	50-56
26552706-5	2015	Cytotoxicity and cytokine production triggered by DNAM-1 were mediated via a conserved tyrosine- and asparagine-based motif in the cytoplasmic domain of DNAM-1.	Asparagine	101-111	CD226 molecule	Homo sapiens	153-159
26183761-13	2015	Surprisingly, mutations at Glu, Asp or Asn residues in the hydrophobic core that are known to be essential for Ca(2+)-induced activation of ANO1 blocked the acid-induced inhibition.	Asparagine	39-42	anoctamin 1	Homo sapiens	140-144
25687434-2	2015	FIH-1 hydrolyzes asparagine at the C-terminal of HIF-1alpha, preventing the interaction between HIF-1alpha and its associated cofactors, and leading to suppressed activation of HIF-1.	Asparagine	17-27	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	0-5
26312620-1	2015	PURPOSE: To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn).	Asparagine	204-207	fibronectin 1	Homo sapiens	153-164
25687434-2	2015	FIH-1 hydrolyzes asparagine at the C-terminal of HIF-1alpha, preventing the interaction between HIF-1alpha and its associated cofactors, and leading to suppressed activation of HIF-1.	Asparagine	17-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
25687434-2	2015	FIH-1 hydrolyzes asparagine at the C-terminal of HIF-1alpha, preventing the interaction between HIF-1alpha and its associated cofactors, and leading to suppressed activation of HIF-1.	Asparagine	17-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
25687434-2	2015	FIH-1 hydrolyzes asparagine at the C-terminal of HIF-1alpha, preventing the interaction between HIF-1alpha and its associated cofactors, and leading to suppressed activation of HIF-1.	Asparagine	17-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
26318253-7	2015	Restricting asparagine replicates the physiology within the blood-brain-barrier, with limited transfer of dietary derived asparagine, resulting in reliance of neuronal cells on intracellular asparagine synthesis by the ASNS enzyme.	Asparagine	12-22	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	219-223
26499495-3	2015	Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.	Asparagine	13-23	asparagine synthetase	Mus musculus	36-40
26378231-8	2015	Computational analysis revealed that most natural cAMP-sensing CRP homologs have Thr/Ser, Thr/Thr, or Thr/Asn at positions 127 and 128.	Asparagine	106-109	catabolite gene activator protein	Escherichia coli	63-66
26435141-0	2015	Asparagine deamidation reduces DNA-binding affinity of the Drosophila melanogaster Scr homeodomain.	Asparagine	0-10	Sex combs reduced	Drosophila melanogaster	83-86
26435141-2	2015	Residue Asn 321 is the main site of deamidation of the Drosophila melanogaster Hox transcription factor Sex Combs Reduced (Scr).	Asparagine	8-11	tinman	Drosophila melanogaster	79-82
26435141-2	2015	Residue Asn 321 is the main site of deamidation of the Drosophila melanogaster Hox transcription factor Sex Combs Reduced (Scr).	Asparagine	8-11	Sex combs reduced	Drosophila melanogaster	104-121
26499495-3	2015	Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.	Asparagine	13-23	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	235-239
26435141-2	2015	Residue Asn 321 is the main site of deamidation of the Drosophila melanogaster Hox transcription factor Sex Combs Reduced (Scr).	Asparagine	8-11	Sex combs reduced	Drosophila melanogaster	123-126
26499495-3	2015	Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.	Asparagine	13-23	cyclin dependent kinase inhibitor 2A	Mus musculus	258-264
26499495-5	2015	These effects of ASNS silencing were reversed by exogenous supplementation with asparagine.	Asparagine	80-90	asparagine synthetase	Mus musculus	17-21
26499495-6	2015	Also, asparagine depletion via the ASNS inhibitor amino sulfoximine 5 (AS5) or asparaginase inhibited mouse and human sarcoma growth in vitro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagine inhibited tumor growth in vivo.	Asparagine	6-16	asparagine synthetase	Mus musculus	35-39
26499495-6	2015	Also, asparagine depletion via the ASNS inhibitor amino sulfoximine 5 (AS5) or asparaginase inhibited mouse and human sarcoma growth in vitro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagine inhibited tumor growth in vivo.	Asparagine	6-16	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	168-172
26499495-6	2015	Also, asparagine depletion via the ASNS inhibitor amino sulfoximine 5 (AS5) or asparaginase inhibited mouse and human sarcoma growth in vitro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagine inhibited tumor growth in vivo.	Asparagine	230-240	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	168-172
26115868-11	2015	We find that the mutation of Asn residues 90 and 98 results in a reduction in cell surface CRFR1 that is comparable to the effect of CAL overexpression and that these mutants are retained in the Golgi apparatus.	Asparagine	29-32	corticotropin releasing hormone receptor 1	Homo sapiens	91-96
26281976-4	2015	We describe here the expression in the yeast Pichia pastoris of a mutant bovine beta-LG, in which lysine at position 69, in the main epitopes of the protein, was changed into asparagine (Lys69Asn).	Asparagine	175-185	beta-lactoglobulin	Bos taurus	80-87
26336134-6	2015	On the other hand, the functional expression of HRG was also dependent on the glycosylation status at its N-terminal, especially at the glycosylation site Asn 125.	Asparagine	155-158	histidine rich glycoprotein	Homo sapiens	48-51
26392216-2	2015	Density functional theory (DFT) calculations indicate that the Amide III(P) (AmIII(P)) vibrations of Gln and Asn depend cosinusoidally on their side chain OCCC dihedral angles (the chi3 and chi2 angles of Gln and Asn, respectively).	Asparagine	109-112	chitinase 1	Homo sapiens	181-185
26392216-8	2015	Using a Protein Data Bank library, we show that the chi3 and chi2 dihedral angles of Gln and Asn depend on the peptide backbone Ramachandran angles.	Asparagine	93-96	chitinase 1	Homo sapiens	52-56
26115868-12	2015	Mutation of Asn residues 90 and 98 also results in a decrease in the efficacy for CRF-stimulated cAMP formation mediated by CRFR1.	Asparagine	12-15	corticotropin releasing hormone receptor 1	Homo sapiens	124-129
26752859-5	2015	The study resulted in a novel, here though unreported, heterozygous mutation in FSHR gene at nucleotide position 1346 (AC(1346)T to AAT) in exon 10 yielding a threonine to asparagine (Thr(449)Asn) substitution in the transmembrane domain helix 3 of the FSHR.	Asparagine	172-182	follicle stimulating hormone receptor	Homo sapiens	80-84
26175110-6	2015	Similar mutagenesis of a single residue in the C2B-domain of copine-6 (but not copine-2 and copine-7) was sufficient to eliminate its calcium-mediated membrane binding, and simultaneous substitution of all four of the asparagines in the C2B-domain resulted in constitutive membrane association of copine-2, copine-6 and copine-7 with the plasma membrane.	Asparagine	218-229	copine 6	Homo sapiens	61-69
26752859-5	2015	The study resulted in a novel, here though unreported, heterozygous mutation in FSHR gene at nucleotide position 1346 (AC(1346)T to AAT) in exon 10 yielding a threonine to asparagine (Thr(449)Asn) substitution in the transmembrane domain helix 3 of the FSHR.	Asparagine	172-182	serpin family A member 1	Homo sapiens	132-135
26752859-5	2015	The study resulted in a novel, here though unreported, heterozygous mutation in FSHR gene at nucleotide position 1346 (AC(1346)T to AAT) in exon 10 yielding a threonine to asparagine (Thr(449)Asn) substitution in the transmembrane domain helix 3 of the FSHR.	Asparagine	172-182	follicle stimulating hormone receptor	Homo sapiens	253-257
26332741-6	2015	The Asp   Asn mutation in the GY/FDFLGL motif abolishes the interaction between MYB transcription factors and SAD2, and therefore they cannot be transported into the nucleus and cannot repress their target genes.	Asparagine	10-13	ARM repeat superfamily protein	Arabidopsis thaliana	110-114
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Asparagine	88-91	putative anthocyanidin reductase	Gossypium hirsutum	71-74
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Asparagine	88-91	putative anthocyanidin reductase	Gossypium hirsutum	198-201
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Asparagine	207-210	putative anthocyanidin reductase	Gossypium hirsutum	71-74
26348906-6	2015	Based on homology modelling, we identified two sites (Asn(171) and Asn(183)) in the extracellular loop 2 (EL2) of BGT-1, which were investigated with respect to trafficking, insertion and transport by immunogold-labelling, electron microscopy (EM), mutagenesis and two-electrode voltage clamp measurements in Xenopus laevis oocytes and uptake of radiolabelled substrate into MDCK (Madin-Darby canine kidney) and HEK293 (human embryonic kidney) cells.	Asparagine	54-57	solute carrier family 6 member 12	Canis lupus familiaris	114-119
26348906-6	2015	Based on homology modelling, we identified two sites (Asn(171) and Asn(183)) in the extracellular loop 2 (EL2) of BGT-1, which were investigated with respect to trafficking, insertion and transport by immunogold-labelling, electron microscopy (EM), mutagenesis and two-electrode voltage clamp measurements in Xenopus laevis oocytes and uptake of radiolabelled substrate into MDCK (Madin-Darby canine kidney) and HEK293 (human embryonic kidney) cells.	Asparagine	67-70	solute carrier family 6 member 12	Canis lupus familiaris	114-119
26170455-8	2015	Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3).	Asparagine	112-115	C-type lectin domain family 18 member A	Homo sapiens	10-16
26178806-1	2015	The present treatment of childhood T-cell leukemias involves the systemic administration of prokaryotic L-asparaginase (ASNase), which depletes plasma Asparagine (Asn) and inhibits protein synthesis.	Asparagine	151-161	asparaginase and isoaspartyl peptidase 1	Homo sapiens	104-118
26178806-1	2015	The present treatment of childhood T-cell leukemias involves the systemic administration of prokaryotic L-asparaginase (ASNase), which depletes plasma Asparagine (Asn) and inhibits protein synthesis.	Asparagine	151-161	asparaginase and isoaspartyl peptidase 1	Homo sapiens	120-126
26178806-1	2015	The present treatment of childhood T-cell leukemias involves the systemic administration of prokaryotic L-asparaginase (ASNase), which depletes plasma Asparagine (Asn) and inhibits protein synthesis.	Asparagine	163-166	asparaginase and isoaspartyl peptidase 1	Homo sapiens	104-118
26178806-1	2015	The present treatment of childhood T-cell leukemias involves the systemic administration of prokaryotic L-asparaginase (ASNase), which depletes plasma Asparagine (Asn) and inhibits protein synthesis.	Asparagine	163-166	asparaginase and isoaspartyl peptidase 1	Homo sapiens	120-126
26178806-3	2015	Protein expression from genes bearing Asn homopolymeric coding regions (N-hCR) may be particularly susceptible to Asn level fluctuation.	Asparagine	38-41	coiled-coil alpha-helical rod protein 1	Homo sapiens	74-77
26178806-6	2015	This paper proposes that dysregulation of Asn homeostasis, potentially even by ASNase produced by the microbiome, may contribute to several clinically important syndromes by altering expression of N-hCR bearing genes.	Asparagine	42-45	coiled-coil alpha-helical rod protein 1	Homo sapiens	199-202
26268886-1	2015	Upon translation, the N-terminal homology box 1 (NHB1) signal anchor sequence of Nrf1 integrates it within the endoplasmic reticulum (ER) whilst its transactivation domains [TADs, including acidic domain 1 (AD1), the flanking Asn/Ser/Thr-rich (NST) domain and AD2] are transiently translocated into the ER lumen, whereupon the NST domain is glycosylated to yield an inactive 120-kDa glycoprotein.	Asparagine	226-229	nuclear respiratory factor 1	Homo sapiens	81-85
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Asparagine	300-303	meprin A subunit beta	Homo sapiens	122-133
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Asparagine	300-303	transmembrane serine protease 6	Homo sapiens	179-186
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Asparagine	300-303	transmembrane serine protease 6	Homo sapiens	190-202
26067270-7	2015	Moreover, the structure reflects the close relationship among Gln-183 in the QXE motif (C3), a modified Asn-41 residue (RhoA) and NC1 of NAD(H), which suggests that C3 is the prototype ART.	Asparagine	104-107	ras homolog family member A	Homo sapiens	120-124
26041303-6	2015	The thioredoxin domain of Trx2 and the asparagine at position 37 (N37) in the E2 protein were shown to be critical for the interaction.	Asparagine	39-49	ubiquitin conjugating enzyme E2 B	Homo sapiens	78-88
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	Janus kinase 2	Bos taurus	34-38
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	SCS	Bos taurus	175-193
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	SCS	Bos taurus	195-198
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	signal transducer and activator of transcription 5B	Bos taurus	229-235
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	SCC	Bos taurus	270-273
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	SCS	Bos taurus	275-278
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	interleukin 4	Bos taurus	283-296
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Asparagine	93-103	interleukin 4	Bos taurus	298-302
25824433-0	2015	Asn-Linked Glycosylation Contributes to Surface Expression and Voltage-Dependent Gating of Cav1.2 Ca2+ Channel.	Asparagine	0-3	calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog	Xenopus laevis	91-97
25824433-2	2015	We mutated single, double, and quadruple sites of the four potential Asn (N)-glycosylation sites in the rabbit Cav1.2 into Gln (Q) to explore the effects of Nglycosylation.	Asparagine	69-72	calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog	Xenopus laevis	111-117
26063421-7	2015	We characterized the prevalence of functional CD4 alleles in a colony of captive Spix"s owl monkeys and found that 88% of surveyed individuals are homozygous for permissive CD4 alleles, which encode an asparagine at position 39 of the receptor.	Asparagine	202-212	CD4 molecule	Homo sapiens	46-49
26063421-7	2015	We characterized the prevalence of functional CD4 alleles in a colony of captive Spix"s owl monkeys and found that 88% of surveyed individuals are homozygous for permissive CD4 alleles, which encode an asparagine at position 39 of the receptor.	Asparagine	202-212	CD4 molecule	Homo sapiens	173-176
26036575-8	2015	Importantly, the back mutation of the FR 76 residue of VH (H76) (Asn to Ser) was critical in preserving the pT231-binding motif conformation via allosteric regulation of ArgH71, which closely interacts with ThrH52 and SerH52a residues on VH-CDR2 to induce the unique phosphate-binding bowl-like conformation.	Asparagine	65-68	cerebellar degeneration related protein 2	Homo sapiens	241-245
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Asparagine	115-118	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
26045554-4	2015	Using biochemistry, confocal and electron microscopy, and electrophysiology in conjunction with a lentivirus-based molecular replacement strategy, we found that NMDARs are released from the ER only when two asparagine residues in the GluN1 subunit (Asn-203 and Asn-368) are N-glycosylated.	Asparagine	207-217	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	234-239
26045554-4	2015	Using biochemistry, confocal and electron microscopy, and electrophysiology in conjunction with a lentivirus-based molecular replacement strategy, we found that NMDARs are released from the ER only when two asparagine residues in the GluN1 subunit (Asn-203 and Asn-368) are N-glycosylated.	Asparagine	249-252	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	234-239
26045554-4	2015	Using biochemistry, confocal and electron microscopy, and electrophysiology in conjunction with a lentivirus-based molecular replacement strategy, we found that NMDARs are released from the ER only when two asparagine residues in the GluN1 subunit (Asn-203 and Asn-368) are N-glycosylated.	Asparagine	261-264	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	234-239
25943393-3	2015	Using nucleotide diversity data, we show that there is a single fixed nucleotide difference between maize and teosinte in tga1, and this difference confers a Lys (teosinte allele) to Asn (maize allele) substitution.	Asparagine	183-186	teosinte glume architecture 1	Zea mays	122-126
25870943-11	2015	In conclusion, the speculated regulatory role of ORF1 X-domain in HEV replication cycle critically depends on the "Asn, Asn, His, Gly, Gly, Gly" segment/secondary structure.	Asparagine	115-118	polyprotein	Orthohepevirus A	49-53
25870943-11	2015	In conclusion, the speculated regulatory role of ORF1 X-domain in HEV replication cycle critically depends on the "Asn, Asn, His, Gly, Gly, Gly" segment/secondary structure.	Asparagine	120-123	polyprotein	Orthohepevirus A	49-53
26171609-2	2015	Here, we show that SPINT 2 is expressed as two species of different size (30-40- versus 25-kDa) due to different N-glycans on Asn-57.	Asparagine	126-129	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	19-26
25862406-2	2015	In the homology structural model of ASCT2 these Asn residues are extracellularly exposed.	Asparagine	48-51	solute carrier family 1 member 5	Homo sapiens	36-41
25916169-6	2015	By pharmacological, biochemical and site-directed mutagenesis, we observed that ST3Gal-II is mostly N-glycosylated at Asn(211) and that this co-translational modification is critical for its exit from the endoplasmic reticulum and proper Golgi localization.	Asparagine	118-121	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	80-89
26079268-0	2015	Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling and their negative regulators.	Asparagine	0-10	toll like receptor 4	Sus scrofa	114-134
25753114-3	2015	In particular, in a patient with severe early-onset obesity, a novel heterozygous mutation in the MC4R gene was found in an exchange of Asp to Asn in the 90th amino acid residue located in the TM 2 domain (MC4RD90N).	Asparagine	143-146	melanocortin 4 receptor	Homo sapiens	98-102
25898270-6	2015	The most potent peptide from this library was an asparagine to diaminopropionic acid substitution that possessed sub-nanomolar antagonist activity at the mMC4R and was greater than 160-fold selective for the mMC4R versus the mMC3R.	Asparagine	49-59	melanocortin 4 receptor	Mus musculus	154-159
25898270-6	2015	The most potent peptide from this library was an asparagine to diaminopropionic acid substitution that possessed sub-nanomolar antagonist activity at the mMC4R and was greater than 160-fold selective for the mMC4R versus the mMC3R.	Asparagine	49-59	melanocortin 4 receptor	Mus musculus	208-213
25898270-6	2015	The most potent peptide from this library was an asparagine to diaminopropionic acid substitution that possessed sub-nanomolar antagonist activity at the mMC4R and was greater than 160-fold selective for the mMC4R versus the mMC3R.	Asparagine	49-59	melanocortin 3 receptor	Mus musculus	225-230
26039991-5	2015	We found that the protein product of an alternatively spliced Junctin isoform is N-glycosylated at a specific asparagine site that is required for interactions with specific protein partners.	Asparagine	110-120	aspartate-beta-hydroxylase	Mus musculus	62-69
25935222-5	2015	For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction.	Asparagine	72-82	alanyl-tRNA synthetase 1	Homo sapiens	154-158
26087092-3	2015	The mutation is concurrent with a single-nucleotide polymorphism and resulted in a serine for asparagine substitution in H1 subdomain of KRT6A chain next to the rod domain.	Asparagine	94-104	keratin 6A	Homo sapiens	137-142
26132828-11	2015	Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.	Asparagine	43-53	peptidyl arginine deiminase 1	Homo sapiens	88-92
26132828-11	2015	Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.	Asparagine	43-53	peptidyl arginine deiminase 4	Homo sapiens	93-97
25690651-3	2015	We found that human GPR109A (hGPR109A) has an N-glycosylation site at Asn(17) in the N-terminal atypical motif, Asn(17)-Cys(18)-Cys(19).	Asparagine	70-73	hydroxycarboxylic acid receptor 2	Homo sapiens	20-27
25690651-3	2015	We found that human GPR109A (hGPR109A) has an N-glycosylation site at Asn(17) in the N-terminal atypical motif, Asn(17)-Cys(18)-Cys(19).	Asparagine	70-73	hydroxycarboxylic acid receptor 2	Homo sapiens	29-37
25690651-3	2015	We found that human GPR109A (hGPR109A) has an N-glycosylation site at Asn(17) in the N-terminal atypical motif, Asn(17)-Cys(18)-Cys(19).	Asparagine	112-115	hydroxycarboxylic acid receptor 2	Homo sapiens	20-27
25690651-3	2015	We found that human GPR109A (hGPR109A) has an N-glycosylation site at Asn(17) in the N-terminal atypical motif, Asn(17)-Cys(18)-Cys(19).	Asparagine	112-115	hydroxycarboxylic acid receptor 2	Homo sapiens	29-37
25690651-5	2015	Here we show that Asn(17)-Cys(18)-Cys(19) sequence of hGPR109A possesses 2 biologic roles.	Asparagine	18-21	hydroxycarboxylic acid receptor 2	Homo sapiens	54-62
25690651-6	2015	First, Asn(17)-X-Cys(19) contributed to hGPR109A N-glycosylation by acting as an atypical motif.	Asparagine	7-10	hydroxycarboxylic acid receptor 2	Homo sapiens	40-48
25690651-7	2015	This modification is required for the normal surface expression of hGPR109A, as evidenced by the reduced surface expression of the nonglycosylated mutants, hGPR109A/N17A, and the finding that hGPR109A/C19S and hGPR109A/C19T, which are N-glycosylated at Asn(17), exhibited expression similar to the wild-type receptor.	Asparagine	253-256	hydroxycarboxylic acid receptor 2	Homo sapiens	67-75
25690651-11	2015	Together, these results suggest that the atypical motif Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hGPR109A.	Asparagine	56-59	hydroxycarboxylic acid receptor 2	Homo sapiens	142-150
25897024-8	2015	Mutagenesis of the RNA-binding triad of SmD3 (Ser-Asn-Arg) and SmB (His-Asn-Arg) provided insights to built-in redundancies of the Sm ring, whereby no individual side-chain was essential, but simultaneous mutations of Asn or Arg residues in SmD3 and SmB were lethal.	Asparagine	50-53	mRNA splicing protein SMD3	Saccharomyces cerevisiae S288C	40-44
25393506-1	2015	Asparaginase, an enzyme used to treat acute lymphoblastic leukemia and related forms of nonHodgkin lymphoma, depletes asparagine, which leads to lymphoblast cell death.	Asparagine	118-128	asparaginase	Homo sapiens	0-12
25837412-6	2015	But, at the same time, several crucial noncovalent bonds came from other amino acid residues, e.g. Arg-194 and Arg-198 (albumin) and B/Arg-40, B/Asp-99 and B/Asn-102 (hemoglobin) cannot be ignored completely.	Asparagine	158-161	albumin	Homo sapiens	111-157
25897024-9	2015	Asn-to-Ala mutations SmB and SmD3 caused synthetic defects in the absence of Mud1 or Mud2.	Asparagine	0-3	mRNA splicing protein SMD3	Saccharomyces cerevisiae S288C	29-33
25897024-9	2015	Asn-to-Ala mutations SmB and SmD3 caused synthetic defects in the absence of Mud1 or Mud2.	Asparagine	0-3	Mud1p	Saccharomyces cerevisiae S288C	77-81
25897024-9	2015	Asn-to-Ala mutations SmB and SmD3 caused synthetic defects in the absence of Mud1 or Mud2.	Asparagine	0-3	Mud2p	Saccharomyces cerevisiae S288C	85-89
25905771-1	2015	We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43.	Asparagine	59-69	TAR DNA binding protein	Homo sapiens	111-117
25905771-1	2015	We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43.	Asparagine	59-69	TAR DNA binding protein	Homo sapiens	181-187
25943379-11	2015	The PCR positive samples examined (n = 72) showed a high prevalence of dhfr triple (Asn-108 + Arg-59 + Ile-59) mutant (68%) and dhps double (Gly -437 + Glu-540) mutant (21%).	Asparagine	84-87	dihydrofolate reductase	Homo sapiens	71-75
25954252-4	2015	In the N-terminal prion-forming domain, Sup35p has glutamine/asparagine-rich oligopeptide repeats (OPRs), which enable propagation through chaperone-elicited shearing.	Asparagine	61-71	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	40-46
25637522-1	2015	Rhodopsin, a G-protein coupled receptor, most abundant protein in retinal rod photoreceptors, is glycosylated at asparagines-2 and 15 on its N-terminus.	Asparagine	113-124	rhodopsin	Mus musculus	0-9
25724897-9	2015	The primary KLK4 cleavage site in murine ephrin-B2 was verified and shown to correspond to one of the in silico predicted sites between extracellular domain residues arginine 178 and asparagine 179.	Asparagine	183-193	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	12-16
25724897-9	2015	The primary KLK4 cleavage site in murine ephrin-B2 was verified and shown to correspond to one of the in silico predicted sites between extracellular domain residues arginine 178 and asparagine 179.	Asparagine	183-193	ephrin B2	Mus musculus	41-50
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	121-124	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	Rattus norvegicus	53-68
25651845-9	2015	Sequence analysis revealed Thr-315 is a consensus N-linked glycosylation site for Asn-313 and that its elimination significantly (~four- to fivefold) improves the maximum velocity of PC activation by the thrombin-TM complex, explaining the basis for the proband"s negative VTE pedigree.	Asparagine	82-85	coagulation factor II, thrombin	Homo sapiens	204-212
25824821-7	2015	The obligatory glycan was mapped to a single N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394 (N394) in human IgE and N384 in mouse.	Asparagine	125-135	immunoglobulin heavy constant epsilon	Homo sapiens	117-120
25824821-7	2015	The obligatory glycan was mapped to a single N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394 (N394) in human IgE and N384 in mouse.	Asparagine	125-135	immunoglobulin heavy constant epsilon	Homo sapiens	156-159
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	88-98	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	Rattus norvegicus	53-68
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	88-98	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	121-124	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	88-98	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	109-112	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	Rattus norvegicus	53-68
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	121-124	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	109-112	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25425280-6	2015	KEY RESULTS: Mutation of Asn-132(3.33) , Phe-207 and Tyr-271(6.51) within CXCR3 severely impaired both ligand binding and chemotactic responses, suggesting that these residues are critical for maintenance of a functional CXCR3 conformation.	Asparagine	25-28	C-X-C motif chemokine receptor 3	Homo sapiens	74-79
25694427-6	2015	We also determined the minimal Rab35-binding site of centaurin-beta2 and identified two asparagine residues (Asn-610 and Asn-691) in the Rab35-binding site as key residues for its specific Rab35 recognition.	Asparagine	109-112	RAB35, member RAS oncogene family	Rattus norvegicus	137-142
25425280-6	2015	KEY RESULTS: Mutation of Asn-132(3.33) , Phe-207 and Tyr-271(6.51) within CXCR3 severely impaired both ligand binding and chemotactic responses, suggesting that these residues are critical for maintenance of a functional CXCR3 conformation.	Asparagine	25-28	C-X-C motif chemokine receptor 3	Homo sapiens	221-226
25727410-2	2015	Among several prophylactic molecules proven suitable for ameliorating free radical damage, NAP (an octapeptide with initial amino acids: asparagine/N, alanine/A, and proline/P) can be considered superlative, primarily due to its high permeability into brain through blood-brain barrier and observed activity at femtomolar concentrations.	Asparagine	137-147	catenin, beta like 1	Rattus norvegicus	91-94
25342221-5	2015	By utilizing structure-based interaction models, mutagenesis and assays of cCPE-binding to the TJ-free cell line HEK293, transfected with human Cld1 and murine Cld5, we showed how cCPE-binding to Cld1 and Cld5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)).	Asparagine	272-275	claudin 1	Homo sapiens	196-200
25342221-5	2015	By utilizing structure-based interaction models, mutagenesis and assays of cCPE-binding to the TJ-free cell line HEK293, transfected with human Cld1 and murine Cld5, we showed how cCPE-binding to Cld1 and Cld5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)).	Asparagine	272-275	claudin 1	Homo sapiens	196-200
25835533-3	2015	In this study, we show that vGPCR undergoes extensive N-linked glycosylation within the extracellular domains, specifically asparagines 18, 22, 31 and 202.	Asparagine	124-135	K14	Human gammaherpesvirus 8	28-33
25568345-9	2015	The exception is the grasses (e.g., rice, maize, sugarcane, millets); these plants have Galpha subunits that replaced the critical hydroxyl-bearing threonine with a destabilizing asparagine shown to disrupt interaction between Arabidopsis RGS protein (AtRGS1) and the grass Galpha subunit.	Asparagine	179-189	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	252-258
25681283-6	2015	A further prolonged analog, f-Nle-Leu-Phe-Nle-Tyr-Lys-(Asn-Gly)5-myc, designed to decrease the possible steric hindrance between FPR1 and the bound anti-myc antibody, has little affinity for the receptor, precluding a direct assessment of this issue.	Asparagine	54-58	formyl peptide receptor 1	Homo sapiens	129-133
25762321-8	2015	In contrast, mutations of Val(168) or Asn(171) in the upper site, which are unique to ROMK within the Kir channel family, led to a dramatic reduction in VU591 sensitivity.	Asparagine	38-41	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	86-90
25658043-4	2015	Here we describe properties of a penta-heme cytochrome c nitrite reductase in which the distal His has been substituted by Asn.	Asparagine	123-126	cytochrome c, somatic	Homo sapiens	44-56
26579605-4	2015	Analysis of the energy revealed that the asparagine and cysteine at residues 11 and 12 play important roles in "recognizing" tRNA(Lys3) via van der Waals interactions, contributing to binding specificity.	Asparagine	41-51	mitochondrially encoded tRNA glycine	Homo sapiens	125-134
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Asparagine	98-101	glucagon like peptide 1 receptor	Homo sapiens	118-123
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Asparagine	98-101	glucagon	Homo sapiens	164-169
25597996-0	2015	Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation.	Asparagine	0-10	X-ray repair cross complementing 4	Homo sapiens	53-58
25602614-6	2015	The kinetics of asparagine dipeptide and two deamidation sites in mammalian TPI are also investigated using quantum mechanical/molecular mechanical tools with the umbrella sampling technique.	Asparagine	16-26	triosephosphate isomerase 1	Homo sapiens	76-79
25602614-8	2015	Our findings show that all the descriptors add up to favor the primary deamidation site over the secondary one in mammalian TPI: Asn71 deamidates faster because it is more solvent accessible, the adjacent glycine NH backbone acidity is enhanced, and the Asn side chain has a preferential near attack conformation.	Asparagine	129-132	triosephosphate isomerase 1	Homo sapiens	124-127
25548276-3	2015	COX-2 is degraded via endoplasmic reticulum (ER)-associated degradation (ERAD) following post-translational glycosylation of Asn-594.	Asparagine	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25548276-8	2015	Substituting this sequence with KDEL, a robust ER retention signal, concentrated COX-2 in the ER where it was stable and slowly glycosylated on Asn-594.	Asparagine	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25310768-7	2015	Haplotypes association showed that association of Gln allele of XRCC1 Arg399Gln polymorphism with the Asn allele of XPDAsp312Asn polymorphism (p = 0.004) or Gln allele of XRCC1 Arg399Gln polymorphism with the Gln allele of XPD Lys751Gln polymorphism (p = 0.003) was highly significantly associated with the development of ESRD.	Asparagine	102-105	X-ray repair cross complementing 1	Homo sapiens	64-69
25521062-6	2015	Native NMU was found to be rapidly cleaved at the C-terminus between Arg(24) and Asn(25) , followed by cleavage between Arg(16) and Gly(17) .	Asparagine	81-84	neuromedin U	Homo sapiens	7-10
25310768-6	2015	Combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with Asp/Asn or Asn/Asn genotypes of XPDAsp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Asparagine	96-99	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	117-120
25310768-7	2015	Haplotypes association showed that association of Gln allele of XRCC1 Arg399Gln polymorphism with the Asn allele of XPDAsp312Asn polymorphism (p = 0.004) or Gln allele of XRCC1 Arg399Gln polymorphism with the Gln allele of XPD Lys751Gln polymorphism (p = 0.003) was highly significantly associated with the development of ESRD.	Asparagine	102-105	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	116-119
25310768-6	2015	Combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with Asp/Asn or Asn/Asn genotypes of XPDAsp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Asparagine	96-99	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	117-120
25533529-8	2015	Taken together, all the glycans contribute to the pharmacokinetics of acutobin and ATB-wt in vivo, and the microenvironment around the Asn(229)-glycan appears to regulate the fibrinogen-chain specificity of acutobin while the N-glycans at positions 77, 81 and 100 are crucial for its folding.	Asparagine	135-138	fibrinogen beta chain	Homo sapiens	175-185
25628020-4	2015	Three of them, Asn-196 in adipocyte plasma membrane-associated protein (APMAP), Asn-91 in cluster of differentiation 166 (CD166/ALCAM), and Asn-76 in thyroglobulin, are human-specific.	Asparagine	15-18	adipocyte plasma membrane associated protein	Homo sapiens	26-70
25628020-4	2015	Three of them, Asn-196 in adipocyte plasma membrane-associated protein (APMAP), Asn-91 in cluster of differentiation 166 (CD166/ALCAM), and Asn-76 in thyroglobulin, are human-specific.	Asparagine	15-18	adipocyte plasma membrane associated protein	Homo sapiens	72-77
25853008-3	2015	CD13 binds peptides and proteins through binding to tripeptide asparagine-glycine-arginine (NGR) amino acid residues.	Asparagine	63-73	alanyl (membrane) aminopeptidase	Mus musculus	0-4
25853008-3	2015	CD13 binds peptides and proteins through binding to tripeptide asparagine-glycine-arginine (NGR) amino acid residues.	Asparagine	63-73	reticulon 4 receptor	Mus musculus	92-95
26483843-1	2015	Two peptides of Pt-A (Glu-Asn-Trp 429 Da) and Pt-B (Glu-Gln-Trp 443 Da) were isolated from venom liquor of Deinagkistrodon acutus.	Asparagine	26-29	pre T cell antigen receptor alpha	Homo sapiens	16-20
25626693-1	2015	Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma.	Asparagine	47-59	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-24
25626693-1	2015	Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma.	Asparagine	47-59	asparaginase and isoaspartyl peptidase 1	Homo sapiens	26-32
25626693-1	2015	Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma.	Asparagine	61-64	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-24
25626693-1	2015	Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma.	Asparagine	61-64	asparaginase and isoaspartyl peptidase 1	Homo sapiens	26-32
25626693-3	2015	The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms.	Asparagine	21-24	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	28-49
25626693-3	2015	The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms.	Asparagine	21-24	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	51-55
25626693-3	2015	The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms.	Asparagine	21-24	asparaginase and isoaspartyl peptidase 1	Homo sapiens	67-73
25626693-3	2015	The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms.	Asparagine	21-24	asparaginase and isoaspartyl peptidase 1	Homo sapiens	247-253
25338779-0	2015	Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.	Asparagine	71-81	NPC intracellular cholesterol transporter 2	Homo sapiens	110-113
25626693-5	2015	The aim of this study was to identify possible ASNase sensitivity/resistance-related genes or pathways using a new asparaginase, namely a pegylated r-crisantaspase, with a focus on classic Asn-compensatory responses and cell death under conditions of Asn/L-glutamine limitation.	Asparagine	251-254	asparaginase and isoaspartyl peptidase 1	Homo sapiens	47-53
25626693-7	2015	The response of malignant NK cell lines to ASNase may depend on Asn-compensatory mechanisms and other cellular processes such as cleavage of BCL2A1, a prosurvival member of the Bcl-2 protein family.	Asparagine	64-67	asparaginase and isoaspartyl peptidase 1	Homo sapiens	43-49
25451932-7	2015	Similarly, N-glycosylation at Asn-231 protected corin from autocleavage in the frizzled-1 domain.	Asparagine	30-33	corin, serine peptidase	Homo sapiens	48-53
25451932-8	2015	Moreover, N-glycosylation at Asn-697 in the scavenger receptor domain and at Asn-1022 in the protease domain is important for corin cell surface targeting and zymogen activation.	Asparagine	29-32	corin, serine peptidase	Homo sapiens	126-131
25451932-8	2015	Moreover, N-glycosylation at Asn-697 in the scavenger receptor domain and at Asn-1022 in the protease domain is important for corin cell surface targeting and zymogen activation.	Asparagine	77-80	corin, serine peptidase	Homo sapiens	126-131
25413349-3	2015	This study demonstrates that the transient receptor potential vanilloid 3 (TRPV3) channel is hydroxylated by FIH on asparagine 242 within the cytoplasmic ARD.	Asparagine	116-126	transient receptor potential cation channel subfamily V member 3	Homo sapiens	33-73
25413349-3	2015	This study demonstrates that the transient receptor potential vanilloid 3 (TRPV3) channel is hydroxylated by FIH on asparagine 242 within the cytoplasmic ARD.	Asparagine	116-126	transient receptor potential cation channel subfamily V member 3	Homo sapiens	75-80
25413349-4	2015	Hypoxia, FIH inhibitors and mutation of asparagine 242 all potentiated TRPV3-mediated current, without altering TRPV3 protein levels, indicating that oxygen-dependent hydroxylation inhibits TRPV3 activity.	Asparagine	40-50	transient receptor potential cation channel subfamily V member 3	Homo sapiens	71-76
25663424-5	2015	RESULTS: We identified a homozygous novel missense mutation in ASNS gene in both probands and we demonstrated low CSF and plasma asparagine in both patients.	Asparagine	129-139	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	63-67
25213400-3	2015	Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan.	Asparagine	76-79	peripheral myelin protein 22	Homo sapiens	67-72
25663424-7	2015	CSF asparagine level is low in this disorder while plasma may be low.	Asparagine	4-14	colony stimulating factor 2	Homo sapiens	0-3
26380122-5	2015	We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice.	Asparagine	208-211	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	18-33
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Asparagine	26-29	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25466186-1	2014	An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively.	Asparagine	3-13	sphingosine kinase 2	Homo sapiens	91-94
25466186-1	2014	An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively.	Asparagine	3-13	potassium calcium-activated channel subfamily N member 3	Homo sapiens	99-102
25118247-5	2014	We conclude that transient binding of substrate polypeptide by Ost3p/Ost6p increases glycosylation efficiency at asparagines proximal and C-terminal to sequestered sequences.	Asparagine	113-124	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Saccharomyces cerevisiae S288C	63-68
25118247-5	2014	We conclude that transient binding of substrate polypeptide by Ost3p/Ost6p increases glycosylation efficiency at asparagines proximal and C-terminal to sequestered sequences.	Asparagine	113-124	dolichyl-diphosphooligosaccharide--protein glycotransferase	Saccharomyces cerevisiae S288C	69-74
25336660-6	2014	Site-directed mutagenesis confirmed four N-glycosylazhytion sites (Asn-67, Asn-91, Asn-436, and Asn-612) in human ADAM8.	Asparagine	67-70	ADAM metallopeptidase domain 8	Homo sapiens	114-119
25336660-6	2014	Site-directed mutagenesis confirmed four N-glycosylazhytion sites (Asn-67, Asn-91, Asn-436, and Asn-612) in human ADAM8.	Asparagine	75-78	ADAM metallopeptidase domain 8	Homo sapiens	114-119
25336660-6	2014	Site-directed mutagenesis confirmed four N-glycosylazhytion sites (Asn-67, Asn-91, Asn-436, and Asn-612) in human ADAM8.	Asparagine	75-78	ADAM metallopeptidase domain 8	Homo sapiens	114-119
25336660-6	2014	Site-directed mutagenesis confirmed four N-glycosylazhytion sites (Asn-67, Asn-91, Asn-436, and Asn-612) in human ADAM8.	Asparagine	75-78	ADAM metallopeptidase domain 8	Homo sapiens	114-119
25394783-1	2015	Human aspartyl-(asparaginyl)-beta-hydroxylase (HAAH) is a type 2 transmembrane protein and an alpha-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of beta-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins.	Asparagine	261-271	aspartate beta-hydroxylase	Homo sapiens	6-45
25394783-1	2015	Human aspartyl-(asparaginyl)-beta-hydroxylase (HAAH) is a type 2 transmembrane protein and an alpha-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of beta-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins.	Asparagine	261-271	aspartate beta-hydroxylase	Homo sapiens	47-51
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Asparagine	49-59	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	74-83
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Asparagine	49-59	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Asparagine	49-59	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Asparagine	49-59	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Asparagine	104-107	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Asparagine	104-107	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Asparagine	104-107	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Asparagine	90-100	glutamate receptor, ionotropic, kainate 3	Mus musculus	104-110
25300029-3	2014	Higher molecular weight glycan structures with a different monosaccharide composition were observed at two sites, namely, Asn-925 and Asn-928 sites in alpha3 integrin isolated from Pkd1(+/+) cells compared with Pkd1(-/-) cells.	Asparagine	122-125	polycystin 1, transient receptor potential channel interacting	Mus musculus	181-185
25300029-3	2014	Higher molecular weight glycan structures with a different monosaccharide composition were observed at two sites, namely, Asn-925 and Asn-928 sites in alpha3 integrin isolated from Pkd1(+/+) cells compared with Pkd1(-/-) cells.	Asparagine	134-137	polycystin 1, transient receptor potential channel interacting	Mus musculus	181-185
25327705-3	2014	As a phospholipase D superfamily member Tdp1 utilizes two catalytic histidines each within a His-Lys-Asn motif.	Asparagine	101-104	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	40-44
25016576-8	2014	Epitope mapping using glycopeptide fragments and in vitro mutagenesis showed that binding of this antibody depends on N-linked glycosylation at asparagine N130 (HXB2 numbering) in the gp120 V1/V2 domain.	Asparagine	144-154	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	184-189
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Asparagine	90-100	glutamate receptor, ionotropic, kainate 3	Mus musculus	224-230
25314669-1	2014	Asparagine-linked glycosylation is an endoplasmic reticulum co- and post-translational modification that enables the transit and function of receptor tyrosine kinase (RTK) glycoproteins.	Asparagine	0-10	ret proto-oncogene	Homo sapiens	141-165
25340539-6	2014	However, substitution by the polar uncharged residues asparagine or glutamine abrogated Brd4 and mitotic chromosome binding.	Asparagine	54-64	bromodomain containing 4	Homo sapiens	88-92
25242145-3	2014	CS suppression reduced TCA cycle activity and diverted oxaloacetate, the substrate of CS, into production of the nonessential amino acids aspartate and asparagine.	Asparagine	152-162	citrate synthase	Homo sapiens	0-2
25242145-6	2014	Coupled with the success of L-asparaginase as a therapy for childhood leukemia, the data suggest that intracellular asparagine is a critical suppressor of apoptosis in many human tumors.	Asparagine	116-126	asparaginase and isoaspartyl peptidase 1	Homo sapiens	28-42
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	Asparagine	180-190	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	59-84
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	Asparagine	180-190	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	86-89
25314669-1	2014	Asparagine-linked glycosylation is an endoplasmic reticulum co- and post-translational modification that enables the transit and function of receptor tyrosine kinase (RTK) glycoproteins.	Asparagine	0-10	ret proto-oncogene	Homo sapiens	167-170
24838186-5	2014	Target region sequencing showed a novel missense mutation at codon 141 (N141Y) of the PSEN2 gene that predicts an Asparagine-to-Tyrosine substitution in the affected individuals.	Asparagine	114-124	presenilin 2	Homo sapiens	86-91
25379385-6	2014	We identified that the Asn(354) and Asn(444) residues in ECM1 were N-glycosylated by mass spectrometry analysis.	Asparagine	23-26	extracellular matrix protein 1	Homo sapiens	57-61
25379385-6	2014	We identified that the Asn(354) and Asn(444) residues in ECM1 were N-glycosylated by mass spectrometry analysis.	Asparagine	36-39	extracellular matrix protein 1	Homo sapiens	57-61
25379385-7	2014	In addition, an N-linked glycan at Asn(354) negatively regulated secretion of ECM1, contrary to LP patient-derived mutants.	Asparagine	35-38	extracellular matrix protein 1	Homo sapiens	78-82
25290918-8	2014	Relative to Nrf1, LCR-F1/Nrf1beta is a weak activator, that is positively regulated by its Asn/Ser/Thr-rich (NST) domain and acidic domain 2 (AD2).	Asparagine	91-94	NFE2 like bZIP transcription factor 1	Homo sapiens	18-24
25038572-0	2014	The role of Asn-212 in the catalytic mechanism of human endonuclease APE1: stopped-flow kinetic study of incision activity on a natural AP site and a tetrahydrofuran analogue.	Asparagine	12-15	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	69-73
25020226-7	2014	The leucine and valine residues insert into the binding groove while the first residue, asparagine, tethers the peptide via an interaction with CPE"s aspartate 225 and the two prolines are required to maintain the tight turn conformation.	Asparagine	88-98	cpe	Clostridium perfringens	144-147
24716743-7	2014	We also found the ANK3 BP-associated variant rs139972937, responsible for an asparagine to serine change (p = 0.042).	Asparagine	77-87	ankyrin 3	Homo sapiens	18-22
25089939-7	2014	The OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes were inversely associated with cancer risk (OR [95% CI] = 0.69 [0.50-0.95] and 1.35 [1.0-1.82], respectively).	Asparagine	37-40	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
25089939-9	2014	CONCLUSIONS: Among four DNA repair gene polymorphisms, the OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes might be recognized as potential genetic markers modifying susceptibility to bladder cancer in Belarus.	Asparagine	92-95	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	80-83
25038572-2	2014	Previous structural and biochemical studies showed that the conserved Asn-212 residue is important for the enzymatic activity of APE1.	Asparagine	70-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	129-133
25038572-3	2014	Here, we report a comprehensive pre-steady-state kinetic analysis of two APE1 mutants, each containing amino acid substitutions at position 212, to ascertain the role of Asn-212 in individual steps of the APE1 catalytic mechanism.	Asparagine	170-173	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	205-209
25038572-9	2014	The analysis of the model structure of N212D APE1 provides evidence for alternate hydrogen bonding between Asn-212 and Asp-210 residues, whereas N212A possesses an extended active site pocket due to Asn removal.	Asparagine	107-110	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-49
25090004-2	2014	Later on, numerous ALS-related mutations were found in either the glycine or glutamine/asparagine-rich region on the TDP-43 C-terminus, which hinted on the importance of mutations on the disease pathogenesis.	Asparagine	87-97	TAR DNA binding protein	Homo sapiens	117-123
25731027-5	2014	It is shown that the frequency of the Asp/Asp genotype is reduced, and the frequency of the Asn allele of the XPD 312 gene is increased in the subgroup of smokers as compared with nonsmokers, which apparently indicates an association of this gene polymorphism with an inclination to smoke.	Asparagine	92-95	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	110-113
24872415-0	2014	N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.	Asparagine	19-29	MHC class I polypeptide-related sequence A	Homo sapiens	130-134
25112526-1	2014	l-asparaginase is an aminohydrolase that deprives leukemia cells of l-asparagine required for protein synthesis.	Asparagine	68-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
24821319-4	2014	We measured the stability of human Pin1 WW domain with PEG-4 at asparagine 19 for a full mutant cycle at two positions thought to influence PEG-protein interaction: Ser16Ala and Tyr23Phe.	Asparagine	64-74	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	35-39
24821319-8	2014	In contrast, in one of the single mutants, PEG preferentially interacts with the protein surface while disrupting the interactions of its asparagine host with a nearby methionine side chain.	Asparagine	138-148	progestagen associated endometrial protein	Homo sapiens	43-46
24821319-10	2014	A simulation with PEG-45 attached to asparagine 19 shows that PEG even can do both in the same context.	Asparagine	37-47	progestagen associated endometrial protein	Homo sapiens	18-21
24821319-10	2014	A simulation with PEG-45 attached to asparagine 19 shows that PEG even can do both in the same context.	Asparagine	37-47	progestagen associated endometrial protein	Homo sapiens	62-65
24699373-9	2014	Bap2-mediated leucine import was inhibited by some amino acids according to the following order of severity: phenylalanine, leucine&gt;isoleucine&gt;methionine, tyrosine&gt;valine&gt;tryptophan; histidine and asparagine had no effect.	Asparagine	209-219	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	0-4
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Asparagine	33-43	bromodomain containing 3	Homo sapiens	109-113
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Asparagine	33-43	bromodomain containing 4	Homo sapiens	115-119
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Asparagine	33-43	tripartite motif containing 24	Homo sapiens	124-130
25000295-6	2014	Further analysis revealed that atdfb-3 seeds contained less total amino acids and individual Asn and Glu as well as NO3-.	Asparagine	93-96	DHFS-FPGS homolog B	Arabidopsis thaliana	31-36
25155931-1	2014	AIM: Determine whether SNPs of OPRM1 118A&gt;G (asn(40)asp), COMT 472G&gt;A (val(158)met) and ARRB2 8622C&gt;T are associated with morphine rescue in newborns on mechanical ventilation.	Asparagine	48-51	opioid receptor mu 1	Homo sapiens	31-36
24702187-4	2014	every second week, and to correlate CSF asparagine concentration with serum L-asparaginase enzyme activity.	Asparagine	40-50	asparaginase and isoaspartyl peptidase 1	Homo sapiens	76-90
24968355-8	2014	Modeling analysis further revealed that kinase domain of AKT binds NQO2 in the vicinity of asparagine 161 located in the resveratrol-binding domain of NQO2.	Asparagine	91-101	AKT serine/threonine kinase 1	Homo sapiens	57-60
24968355-8	2014	Modeling analysis further revealed that kinase domain of AKT binds NQO2 in the vicinity of asparagine 161 located in the resveratrol-binding domain of NQO2.	Asparagine	91-101	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	67-71
24968355-8	2014	Modeling analysis further revealed that kinase domain of AKT binds NQO2 in the vicinity of asparagine 161 located in the resveratrol-binding domain of NQO2.	Asparagine	91-101	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	151-155
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	139-142	hyaluronidase 1	Homo sapiens	0-14
24927598-7	2014	Asparagine-linked (N-linked) glycosylation of ZIP14, particularly the glycosylation at N102, was required for efficient membrane extraction of ZIP14 and therefore is necessary for its iron sensitivity.	Asparagine	0-10	solute carrier family 39 member 14	Homo sapiens	143-148
25061640-0	2014	Reply to Liu: Amino acid 104 asparagine/glutamic acid of p53 is an adaptively selected site for extreme environments in mammals of the Tibet plateau.	Asparagine	29-39	tumor protein p53	Homo sapiens	57-60
24927598-7	2014	Asparagine-linked (N-linked) glycosylation of ZIP14, particularly the glycosylation at N102, was required for efficient membrane extraction of ZIP14 and therefore is necessary for its iron sensitivity.	Asparagine	0-10	solute carrier family 39 member 14	Homo sapiens	46-51
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	130-133	hyaluronidase 1	Homo sapiens	0-14
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	130-133	hyaluronidase 1	Homo sapiens	16-21
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	139-142	hyaluronidase 1	Homo sapiens	16-21
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	139-142	hyaluronidase 1	Homo sapiens	0-14
25009769-1	2014	Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350).	Asparagine	139-142	hyaluronidase 1	Homo sapiens	16-21
25009769-3	2014	Using mass spectrometry, we demonstrated that HYAL1 was N-glycosylated at the three asparagine residues.	Asparagine	84-94	hyaluronidase 1	Homo sapiens	46-51
25009769-6	2014	Thus, HYAL1 is N-glycosylated at the three asparagine residues, and its secretion and enzymatic activity are regulated by N-glycosylation.	Asparagine	43-53	hyaluronidase 1	Homo sapiens	6-11
24504678-8	2014	For ERCC2 Asp312Asn, individuals with the Asn allele were associated with a 1.29-fold (95 % CI=1.13-1.48) increased risk of bladder cancer.	Asparagine	16-19	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-9
24913401-1	2014	The existence of gas-phase electrostatic ion-ion interactions between protonated sites on peptides ([Glu] Fibrinopeptide B, Angiotensin I and [Asn(1), Val(5)]-Angiotensin II) and attaching anions (ClO4(-) and HSO4(-)) derived from strong inorganic acids has been confirmed by CID MS/MS.	Asparagine	143-146	angiotensinogen	Homo sapiens	159-173
24033105-1	2014	l-asparaginase (L-asp), a bacterial enzyme that depletes extracellular asparagine, is used to treat acute lymphoblastic leukemia in humans and a variety of aggressive lymphoid malignancies in dogs.	Asparagine	71-81	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
24033105-1	2014	l-asparaginase (L-asp), a bacterial enzyme that depletes extracellular asparagine, is used to treat acute lymphoblastic leukemia in humans and a variety of aggressive lymphoid malignancies in dogs.	Asparagine	71-81	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-21
24412328-7	2014	Substitution with Asn led to an increase in IC50 values of inhibitors that interact with the catalytic pocket of APB.	Asparagine	18-21	arginyl aminopeptidase	Homo sapiens	113-116
24731805-8	2014	The MCA1 mutation resulted in substitution of asparagine (N) with aspartic acid (D) at position 164 (MCA1(N164D)).	Asparagine	46-56	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	4-8
24731805-8	2014	The MCA1 mutation resulted in substitution of asparagine (N) with aspartic acid (D) at position 164 (MCA1(N164D)).	Asparagine	46-56	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	101-105
24658926-5	2014	The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR=1.295, 95 % CI 1.057-1.498, P=0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.611, 95 % CI 1.027-2.528, P=0.038).	Asparagine	37-40	follicle stimulating hormone receptor	Homo sapiens	32-36
24658926-5	2014	The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR=1.295, 95 % CI 1.057-1.498, P=0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.611, 95 % CI 1.027-2.528, P=0.038).	Asparagine	115-118	follicle stimulating hormone receptor	Homo sapiens	32-36
24658926-5	2014	The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR=1.295, 95 % CI 1.057-1.498, P=0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.611, 95 % CI 1.027-2.528, P=0.038).	Asparagine	115-118	follicle stimulating hormone receptor	Homo sapiens	32-36
24658926-5	2014	The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR=1.295, 95 % CI 1.057-1.498, P=0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.611, 95 % CI 1.027-2.528, P=0.038).	Asparagine	115-118	follicle stimulating hormone receptor	Homo sapiens	32-36
24719335-4	2014	Here we show, using a combination of mass spectrometry and biochemical approaches, that native TRPP2 is glycosylated at five asparagines in the first extracellular loop.	Asparagine	125-136	polycystin 2, transient receptor potential cation channel	Mus musculus	95-100
24883016-8	2014	A C A substitution at position 1440 in exon 3 that changes asparagine (AAC) to lysine (AAA) was identified in affected family members except two probands (III:5 and IV:6).	Asparagine	59-69	glycine-N-acyltransferase	Homo sapiens	71-74
24719335-5	2014	Glycosylation is required for the efficient biogenesis of TRPP2 because mutations of the glycosylated asparagines result in strongly decreased protein expression of the ion channel.	Asparagine	102-113	polycystin 2, transient receptor potential cation channel	Mus musculus	58-63
24657844-0	2014	Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine.	Asparagine	112-124	asparaginase	Homo sapiens	6-30
24828203-2	2014	The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Calpha bond of Xxx-Asp, Xxx-Asn, Xxx-Cys and Gly-Xxx residues.	Asparagine	201-204	albumin	Homo sapiens	32-45
24828203-2	2014	The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Calpha bond of Xxx-Asp, Xxx-Asn, Xxx-Cys and Gly-Xxx residues.	Asparagine	201-204	thioredoxin	Homo sapiens	67-78
24657844-0	2014	Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine.	Asparagine	112-124	asparaginase and isoaspartyl peptidase 1	Homo sapiens	54-68
24480451-1	2014	The asparagine-glycine-arginine (NGR) peptide sequence found by phage display, was radiolabeled with technetium-99m and tested in different tumor models.	Asparagine	4-14	reticulon 4 receptor	Homo sapiens	33-36
24628331-4	2014	A total of 14 unique N-linked glycans corresponding to 27 unique N-linked glycopeptides were characterized at three N-linked sites (Asn-86, -169, and -242) present in VTN.	Asparagine	132-135	vitronectin	Homo sapiens	167-170
24720891-2	2014	N-glycosylation in ER is mediated by oligosaccharyltransferase (OST), an enzyme complex transferring preassembled oligosaccharide to asparagine residues of nascent polypeptide chain.	Asparagine	133-143	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	37-62
24720891-2	2014	N-glycosylation in ER is mediated by oligosaccharyltransferase (OST), an enzyme complex transferring preassembled oligosaccharide to asparagine residues of nascent polypeptide chain.	Asparagine	133-143	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	64-67
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Asparagine	113-123	aspartate beta-hydroxylase	Homo sapiens	0-4
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Asparagine	113-123	aspartate beta-hydroxylase	Homo sapiens	13-50
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Asparagine	113-123	aspartate beta-hydroxylase	Homo sapiens	52-56
24254056-5	2014	Compared to withdrawal of an essential amino acid, leucine (Leu), withdrawal of either Asn or Gln induced fewer changes in downstream effectors of mammalian target of rapamycin (mTOR) signaling involved in regulation of global protein synthesis.	Asparagine	87-90	mechanistic target of rapamycin kinase	Homo sapiens	147-176
24254056-5	2014	Compared to withdrawal of an essential amino acid, leucine (Leu), withdrawal of either Asn or Gln induced fewer changes in downstream effectors of mammalian target of rapamycin (mTOR) signaling involved in regulation of global protein synthesis.	Asparagine	87-90	mechanistic target of rapamycin kinase	Homo sapiens	178-182
24463019-3	2014	The SNP g2696: A&gt;G resulted in a change from asparagine to aspartic acid (p. N574D) in the leucine-rich repeat region in the carboxyl-terminal domain of IGFALS.	Asparagine	48-58	insulin-like growth factor-binding protein complex acid labile subunit	Bos taurus	156-162
24505127-3	2014	However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis.	Asparagine	32-42	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	55-59
24695487-4	2014	Thus after Nrf1 is anchored within ER membranes, its acidic transactivation domains (TADs), including the Asn/Ser/Thr-rich (NST) glycodomain situated between acidic domain 1 (AD1) and AD2, are transiently translocated into the lumen of the ER, where NST is glycosylated in the presence of glucose to yield an inactive 120-kDa Nrf1 glycoprotein.	Asparagine	106-109	amyloid beta precursor protein	Homo sapiens	175-178
24510189-8	2014	They also revealed a crucial role for a conserved asparagine-arginine containing loop (the NR-loop) in the DCP1 EVH1 domain in DCP2 activation.	Asparagine	50-60	decapping mRNA 1B	Homo sapiens	107-111
24510189-8	2014	They also revealed a crucial role for a conserved asparagine-arginine containing loop (the NR-loop) in the DCP1 EVH1 domain in DCP2 activation.	Asparagine	50-60	decapping mRNA 2	Homo sapiens	127-131
24607902-6	2014	Asn-438 of Doa1/PFU and Trp-254 of Hse1/SH3 are found to be critical in the interaction while Phe-434, implicated in ubiquitin binding via a hydrophobic interaction, is not.	Asparagine	0-3	phospholipase A2 activating protein	Homo sapiens	11-15
24509848-5	2014	Here, we report that N-glycosylation at the Asn(211) residue plays a unique role in the control of DDR1 dimerization and autophosphorylation.	Asparagine	44-47	discoidin domain receptor tyrosine kinase 1	Homo sapiens	99-103
24607902-6	2014	Asn-438 of Doa1/PFU and Trp-254 of Hse1/SH3 are found to be critical in the interaction while Phe-434, implicated in ubiquitin binding via a hydrophobic interaction, is not.	Asparagine	0-3	heparanase	Homo sapiens	35-39
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Asparagine	75-78	heat shock protein family A (Hsp70) member 5	Homo sapiens	103-108
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Asparagine	75-78	nuclear factor kappa B subunit 1	Homo sapiens	144-153
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Asparagine	121-124	heat shock protein family A (Hsp70) member 5	Homo sapiens	103-108
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Asparagine	121-124	nuclear factor kappa B subunit 1	Homo sapiens	144-153
24440310-2	2014	Recently, an Asn/Gln rich C-terminal segment of TDP-43 has been shown to produce aggregation in vitro and reproduce most of the protein"s pathological hallmarks in cells, but little is known about this segment"s structure.	Asparagine	13-16	TAR DNA binding protein	Homo sapiens	48-54
24637349-6	2014	Sequencing of the candidate genes showed a heterozygous c.69 G T change in the heat shock transcription factor 4 (HSF4) gene, which resulted in the substitution of a lysine with an asparagine (p. K23N).	Asparagine	181-191	heat shock transcription factor 4	Homo sapiens	79-112
24637349-6	2014	Sequencing of the candidate genes showed a heterozygous c.69 G T change in the heat shock transcription factor 4 (HSF4) gene, which resulted in the substitution of a lysine with an asparagine (p. K23N).	Asparagine	181-191	heat shock transcription factor 4	Homo sapiens	114-118
23904095-3	2014	Certain amino acids, primarily asparagine (ASN) and GLN stimulate ODC activity in a solution of physiological salts.	Asparagine	31-41	ornithine decarboxylase 1	Homo sapiens	66-69
23904095-3	2014	Certain amino acids, primarily asparagine (ASN) and GLN stimulate ODC activity in a solution of physiological salts.	Asparagine	43-46	ornithine decarboxylase 1	Homo sapiens	66-69
23904095-7	2014	These data, therefore, explain why ASN or GLN is essential for the activation of ODC.	Asparagine	35-38	ornithine decarboxylase 1	Homo sapiens	81-84
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Asparagine	32-35	ornithine decarboxylase 1	Homo sapiens	54-57
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Asparagine	32-35	ornithine decarboxylase antizyme 1	Homo sapiens	75-77
24629124-7	2014	Similarly, a candidate LMW-m type gene was mutated at position 23 to replace threonine with asparagine.	Asparagine	92-102	LMW-GS P-21	Triticum aestivum	23-28
24629124-9	2014	CONCLUSIONS: Our results show that the formation of LMW-s type relies on the presence of an asparagine residue close to the N-terminus generated by signal peptide cleavage, and that LMW-GS can be quantitatively processed most likely by vacuolar asparaginyl endoproteases, suggesting that those accumulated in the vacuole are not sequestered into stable aggregates that would hinder the action of proteolytic enzymes.	Asparagine	92-102	low-molecular-weight glutenin subunit group 5 type III	Triticum aestivum	182-188
24333172-6	2014	The SNP rs7969300 is a non-synonymous SNP causing a Ser to Asn substitution, which is predicted to increase the protein stability of ATXN2.	Asparagine	59-62	ataxin 2	Homo sapiens	133-138
24407422-1	2014	Asparaginyl endopeptidase (AEP) is an endo/lysosomal cysteine endopeptidase with a preference for an asparagine residue at the P1 site and plays an important role in the maturation of toll-like receptors 3/7/9.	Asparagine	101-111	legumain	Homo sapiens	27-30
24361341-7	2014	Site-directed mutagenesis identified N-glycosylation sites at Asn(161) and Asn(241) on the extracellular loop of mouse NOX1.	Asparagine	62-65	NADPH oxidase 1	Mus musculus	119-123
24407422-1	2014	Asparaginyl endopeptidase (AEP) is an endo/lysosomal cysteine endopeptidase with a preference for an asparagine residue at the P1 site and plays an important role in the maturation of toll-like receptors 3/7/9.	Asparagine	101-111	legumain	Homo sapiens	0-25
24361341-7	2014	Site-directed mutagenesis identified N-glycosylation sites at Asn(161) and Asn(241) on the extracellular loop of mouse NOX1.	Asparagine	75-78	NADPH oxidase 1	Mus musculus	119-123
24474640-1	2014	Increased levels of asparagine synthetase (ASNS), an enzyme producing intracellular asparagine, have been implicated in the development of asparaginase resistance.	Asparagine	20-30	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	43-47
24336949-0	2014	Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation.	Asparagine	0-10	bone morphogenetic protein 2	Homo sapiens	35-63
24336949-5	2014	To identify the specific glycosylation sites, we abolished potential sites of N-linked glycosylation (Asn-Xaa-Ser/Thr) in BMP-2 by mutating the Asn residues to Gln individually or in combination, expressed the BMP-2 mutants in Chinese hamster ovary (CHO) and human embryonic kidney 293T (HEK293T) cells and determined their glycosylation state by using peptide:N-glycosidase F and endoglycosidase H digestion.	Asparagine	102-105	bone morphogenetic protein 2	Cricetulus griseus	122-127
24336949-5	2014	To identify the specific glycosylation sites, we abolished potential sites of N-linked glycosylation (Asn-Xaa-Ser/Thr) in BMP-2 by mutating the Asn residues to Gln individually or in combination, expressed the BMP-2 mutants in Chinese hamster ovary (CHO) and human embryonic kidney 293T (HEK293T) cells and determined their glycosylation state by using peptide:N-glycosidase F and endoglycosidase H digestion.	Asparagine	144-147	bone morphogenetic protein 2	Cricetulus griseus	122-127
24403586-14	2014	The Env folding process involves extensive cross-linking of 10 Cys residues by disulfide bond formation and heavy N-glycosylation on ~30 Asn residues.	Asparagine	137-140	endogenous retrovirus group K member 20	Homo sapiens	4-7
24461228-8	2014	Treatment with Asn led to decreased transcript levels of omega-amidase in root, while transcript levels of AGT1 are increased under these conditions, suggesting that excess Asn may lead to the accumulation of alpha-ketosuccinamate and alpha-hydroxysuccinamate.	Asparagine	173-176	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	107-111
24375409-7	2014	Asn(7.32) is affected by modifications on position Arg(33) of hPP, suggesting a hydrogen bond between these two residues.	Asparagine	0-3	familial progressive hyperpigmentation 1	Homo sapiens	62-65
24512991-5	2014	Nine polymorphisms were identified within the coding region of the melittin gene, of which one polymorphism that resulted in serine (Ser) to asparagine (Asp) substitution that can potentially effect on biological activities of melittin peptide.	Asparagine	141-151	melittin	Apis mellifera	67-75
24512991-5	2014	Nine polymorphisms were identified within the coding region of the melittin gene, of which one polymorphism that resulted in serine (Ser) to asparagine (Asp) substitution that can potentially effect on biological activities of melittin peptide.	Asparagine	141-151	melittin	Apis mellifera	227-235
24512991-5	2014	Nine polymorphisms were identified within the coding region of the melittin gene, of which one polymorphism that resulted in serine (Ser) to asparagine (Asp) substitution that can potentially effect on biological activities of melittin peptide.	Asparagine	153-156	melittin	Apis mellifera	67-75
24512991-5	2014	Nine polymorphisms were identified within the coding region of the melittin gene, of which one polymorphism that resulted in serine (Ser) to asparagine (Asp) substitution that can potentially effect on biological activities of melittin peptide.	Asparagine	153-156	melittin	Apis mellifera	227-235
24512991-6	2014	Serine-substituted melittin (Mel-S) showed more cytotoxic effect than asparagine-substituted melittin (Mel-N) against E. coli.	Asparagine	70-80	melittin	Apis mellifera	93-101
24512991-6	2014	Serine-substituted melittin (Mel-S) showed more cytotoxic effect than asparagine-substituted melittin (Mel-N) against E. coli.	Asparagine	70-80	macrolide efflux protein	Escherichia coli	103-106
24586388-2	2014	An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis and/or function.	Asparagine	28-38	cyclic nucleotide gated channel subunit beta 3	Canis lupus familiaris	93-98
24605085-5	2014	In the present study, we provide evidence that TRPM4 and TRPM5 are each N-linked glycosylated at a unique residue, Asn(992) and Asn(932), respectively.	Asparagine	115-118	transient receptor potential cation channel subfamily M member 4	Homo sapiens	47-52
24605085-5	2014	In the present study, we provide evidence that TRPM4 and TRPM5 are each N-linked glycosylated at a unique residue, Asn(992) and Asn(932), respectively.	Asparagine	115-118	transient receptor potential cation channel subfamily M member 5	Homo sapiens	57-62
24605085-5	2014	In the present study, we provide evidence that TRPM4 and TRPM5 are each N-linked glycosylated at a unique residue, Asn(992) and Asn(932), respectively.	Asparagine	128-131	transient receptor potential cation channel subfamily M member 4	Homo sapiens	47-52
24605085-5	2014	In the present study, we provide evidence that TRPM4 and TRPM5 are each N-linked glycosylated at a unique residue, Asn(992) and Asn(932), respectively.	Asparagine	128-131	transient receptor potential cation channel subfamily M member 5	Homo sapiens	57-62
24586388-2	2014	An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis and/or function.	Asparagine	40-43	cyclic nucleotide gated channel subunit beta 3	Canis lupus familiaris	93-98
24403531-6	2014	Systematic exchange of BALB/c and C57 residues revealed that Trp(166), Asn(167), and Cys(251) are of major importance for cI binding in Ly49B.	Asparagine	71-74	killer cell lectin-like receptor, subfamily A, member 2	Mus musculus	136-141
24559985-8	2014	In conclusion, FKBP12.6 activates RyR1, whereas FKBP12 activates RyR2 and this selective activator phenotype is determined within the amino acid residues Glu(31), Asp(32), and Trp(59) in FKBP12 and Gln(31), Asn(32), and Phe(59) in FKBP12.6.	Asparagine	207-210	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	48-54
24366863-4	2014	We observed that the exposed (568)NGR site can deamidate under conditions mimicking accelerated Asn aging.	Asparagine	96-99	reticulon 4 receptor	Homo sapiens	34-37
24447265-5	2014	Two residues in the PIR1 phosphate-binding loop (P-loop), a histidine (H154) downstream of C152 and an asparagine (N157) preceding R158, make close contacts with the active site phosphate, and their nonaliphatic side chains are essential for phosphatase activity in vitro.	Asparagine	103-113	dual specificity phosphatase 11	Homo sapiens	20-24
24136402-3	2014	In AD brain, PP2A activity is compromised, probably because I2(PP2A) is overexpressed and is selectively cleaved at asparagine 175 into an N-terminal fragment, I2NTF, and a C-terminal fragment, I2CTF, and both fragments inhibit PP2A.	Asparagine	116-126	SET like protein	Rattus norvegicus	60-67
24366863-1	2014	Asparagine deamidation occurs spontaneously in proteins during aging; deamidation of Asn-Gly-Arg (NGR) sites can lead to the formation of isoAsp-Gly-Arg (isoDGR), a motif that can recognize the RGD-binding site of integrins.	Asparagine	0-10	reticulon 4 receptor	Homo sapiens	98-101
24240276-6	2014	The four uridine nucleotides at the 3" end of U6 snRNA are modularly recognized by Lsm3, Lsm2, Lsm8 and Lsm4, with the uracil base specificity conferred by a highly conserved asparagine residue.	Asparagine	175-185	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	83-87
24240276-6	2014	The four uridine nucleotides at the 3" end of U6 snRNA are modularly recognized by Lsm3, Lsm2, Lsm8 and Lsm4, with the uracil base specificity conferred by a highly conserved asparagine residue.	Asparagine	175-185	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	89-93
24240276-6	2014	The four uridine nucleotides at the 3" end of U6 snRNA are modularly recognized by Lsm3, Lsm2, Lsm8 and Lsm4, with the uracil base specificity conferred by a highly conserved asparagine residue.	Asparagine	175-185	LSM8 homolog, U6 small nuclear RNA associated	Homo sapiens	95-99
24240276-6	2014	The four uridine nucleotides at the 3" end of U6 snRNA are modularly recognized by Lsm3, Lsm2, Lsm8 and Lsm4, with the uracil base specificity conferred by a highly conserved asparagine residue.	Asparagine	175-185	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	104-108
24297261-8	2014	The Tpo(tee) mutation changes the codon for a highly conserved tyrosine to asparagine (p.Y614N), and the Tpo(tee-2J) mutation deletes a splice donor site, which results in exon skipping and aberrant transcripts.	Asparagine	75-85	thyroid peroxidase	Homo sapiens	4-7
24186145-10	2014	The ratio of plasma asparagine to the total amino acids was significantly positively correlated with SHBG level.	Asparagine	20-30	sex hormone binding globulin	Homo sapiens	101-105
24186145-11	2014	CONCLUSIONS: Plasma levels of some specific amino acids, such as arginine, leucine, tyrosine, and asparagine, were associated with the levels of sex hormones, SHBG, or IGF-1 in premenopausal women.	Asparagine	98-108	sex hormone binding globulin	Homo sapiens	159-163
24186145-11	2014	CONCLUSIONS: Plasma levels of some specific amino acids, such as arginine, leucine, tyrosine, and asparagine, were associated with the levels of sex hormones, SHBG, or IGF-1 in premenopausal women.	Asparagine	98-108	insulin like growth factor 1	Homo sapiens	168-173
24581800-7	2014	Based on these analyses, the residues His122 and Lys140 of beta1 and Glu 66, Asn 131, Asp 118, Glu 120, Glu133, Asn135, Ser 137 of beta3 were predicted to play a functional role.	Asparagine	77-80	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	131-136
24285400-6	2014	Furthermore, we demonstrated that B3GALNT2 is N-glycosylated on both Asn-116 and Asn-174 and that this modification is necessary for its secretion in breast cancer cells.	Asparagine	69-72	beta-1,3-N-acetylgalactosaminyltransferase 2	Homo sapiens	34-42
24285400-6	2014	Furthermore, we demonstrated that B3GALNT2 is N-glycosylated on both Asn-116 and Asn-174 and that this modification is necessary for its secretion in breast cancer cells.	Asparagine	81-84	beta-1,3-N-acetylgalactosaminyltransferase 2	Homo sapiens	34-42
24446315-6	2014	Individuals with XPD 711 Asp and XPD 312 Asn alleles responded poorly to chemotherapy when compared with the wide-type genotype.	Asparagine	41-44	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	33-36
24293367-4	2014	In this study, we utilize the unique properties of a mutation of hSERT at a single, highly conserved asparagine on TM1 (Asn-101) to provide several lines of evidence demonstrating mechanistically distinct roles for Na1 and Na2.	Asparagine	101-111	solute carrier family 6 member 4	Homo sapiens	65-70
24293367-4	2014	In this study, we utilize the unique properties of a mutation of hSERT at a single, highly conserved asparagine on TM1 (Asn-101) to provide several lines of evidence demonstrating mechanistically distinct roles for Na1 and Na2.	Asparagine	120-123	solute carrier family 6 member 4	Homo sapiens	65-70
24384087-3	2014	Mass spectrometry mapping revealed that the MT1-MMP cleavage site of human BRCA2 is between Asn-2135 and Leu-2136 ((2132)LSNN/LNVEGG(2141)), and the point mutation L2136D abrogated MT1-MMP cleavage.	Asparagine	92-95	matrix metallopeptidase 14	Homo sapiens	44-51
24384087-3	2014	Mass spectrometry mapping revealed that the MT1-MMP cleavage site of human BRCA2 is between Asn-2135 and Leu-2136 ((2132)LSNN/LNVEGG(2141)), and the point mutation L2136D abrogated MT1-MMP cleavage.	Asparagine	92-95	BRCA2 DNA repair associated	Homo sapiens	75-80
24384087-3	2014	Mass spectrometry mapping revealed that the MT1-MMP cleavage site of human BRCA2 is between Asn-2135 and Leu-2136 ((2132)LSNN/LNVEGG(2141)), and the point mutation L2136D abrogated MT1-MMP cleavage.	Asparagine	92-95	matrix metallopeptidase 14	Homo sapiens	181-188
24365146-2	2014	Here we show that human Nox1 undergoes glycosylation at Asn-162 and Asn-236 in the second and third extracellular loops, respectively.	Asparagine	56-59	NADPH oxidase 1	Homo sapiens	24-28
24365146-2	2014	Here we show that human Nox1 undergoes glycosylation at Asn-162 and Asn-236 in the second and third extracellular loops, respectively.	Asparagine	68-71	NADPH oxidase 1	Homo sapiens	24-28
24000822-5	2014	The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1.	Asparagine	85-88	endothelin converting enzyme 1	Homo sapiens	117-123
24936522-0	2014	Investigation of asparagine deamidation in a SOD1-based biosynthetic human insulin precursor by MALDI-TOF mass spectrometry.	Asparagine	17-27	superoxide dismutase 1	Homo sapiens	45-49
24936522-0	2014	Investigation of asparagine deamidation in a SOD1-based biosynthetic human insulin precursor by MALDI-TOF mass spectrometry.	Asparagine	17-27	insulin	Homo sapiens	75-82
23726040-6	2014	RESULTS: Compared with the C57BL/6 allele, the BALB/c CD11a allele contained a nonsynonymous change from asparagine to aspartic acid within the metal ion binding domain.	Asparagine	105-115	integrin subunit alpha L	Homo sapiens	54-59
26819895-2	2014	Backbone cleavages at the N-Calpha bonds of Xxx-Asp, Xxx-Asn, Xxx-Cys, and Gly-Xxx residues gave discontinuous intense peaks of c-ions, independent of positive and negative ion mode.	Asparagine	57-60	CEA cell adhesion molecule 6	Homo sapiens	26-34
25177232-2	2014	L-ASP"s anticancer activity is believed to be associated primarily with depletion of asparagine, but secondary glutaminase activity has also been implicated in its anticancer mechanism of action.	Asparagine	85-95	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-5
25177232-4	2014	When we examined the response of OVCAR-8 ovarian cancer cells in culture to L-ASP, asparagine was depleted from the medium within seconds.	Asparagine	83-93	asparaginase and isoaspartyl peptidase 1	Homo sapiens	76-81
25177232-5	2014	Interestingly, intracellular asparagine was also depleted rapidly, and the mechanism was suggested to involve rapid export of intracellular asparagine followed by rapid conversion to aspartic acid by L-ASP.	Asparagine	29-39	asparaginase and isoaspartyl peptidase 1	Homo sapiens	200-205
25177232-6	2014	We also found that L-ASP-induced cell death was more closely associated with glutamine concentration than with asparagine concentration.	Asparagine	111-121	asparaginase and isoaspartyl peptidase 1	Homo sapiens	19-24
25491753-7	2014	The Pfl01_0728 and Pfl01_3768 double mutant unexpectedly exhibited stronger responses toward the tomato root exudate and amino acids such as proline, asparagine, methionine, and phenylalanine than those of the wild-type strain.	Asparagine	150-160	PFL01_RS03685	Pseudomonas fluorescens Pf0-1	4-14
25491753-7	2014	The Pfl01_0728 and Pfl01_3768 double mutant unexpectedly exhibited stronger responses toward the tomato root exudate and amino acids such as proline, asparagine, methionine, and phenylalanine than those of the wild-type strain.	Asparagine	150-160	PFL01_RS18910	Pseudomonas fluorescens Pf0-1	19-29
24931196-5	2014	Constitutively active mutants (CAMs) of AT1 receptor have been engineered using molecular modeling and site-directed mutagenesis approaches among which substitution of Asn(111) in the transmembrane helix III with glycine or serine results in the highest basal activity of the receptor.	Asparagine	168-171	angiotensin II receptor type 1	Homo sapiens	40-43
25036486-1	2014	A Japanese patient with Nasu-Hakola disease was found to have a serine-to-asparagine (S39N) substitution in human DNAX-activation protein 12 (DAP12).	Asparagine	74-84	transmembrane immune signaling adaptor TYROBP	Homo sapiens	114-140
25036486-1	2014	A Japanese patient with Nasu-Hakola disease was found to have a serine-to-asparagine (S39N) substitution in human DNAX-activation protein 12 (DAP12).	Asparagine	74-84	transmembrane immune signaling adaptor TYROBP	Homo sapiens	142-147
24521865-4	2014	The results showed that the SNP at A420C was significantly associated with canine body weight trait when it changed amino acid 101 of the MC4R protein from asparagine to threonine, while canine body weight variations were significant in female dogs when MC4R nonsense mutation at C895T.	Asparagine	156-166	melanocortin 4 receptor	Canis lupus familiaris	138-142
24357164-1	2014	Human glycodelin consists of 162 amino acid residues and two N-linked glycans at Asn(28) and Asn(63) .	Asparagine	81-84	progestagen associated endometrial protein	Homo sapiens	6-16
24357164-1	2014	Human glycodelin consists of 162 amino acid residues and two N-linked glycans at Asn(28) and Asn(63) .	Asparagine	93-96	progestagen associated endometrial protein	Homo sapiens	6-16
24349380-6	2013	Standard ALL therapy, which includes l-asparaginase, completely removed circulating asparagine, but not glutamine.	Asparagine	84-94	asparaginase and isoaspartyl peptidase 1	Homo sapiens	37-51
24791469-4	2014	Seven out of 10 residues composing this site (Gln-133, Asn-249, Val-250, Asp-251, Val-252, Asn-253 and Glu-254) are obligatory components of the dinitroanilines" binding site on the plant alpha-tubulin surface.	Asparagine	55-58	tubulin alpha-5	Arabidopsis thaliana	188-201
24791469-4	2014	Seven out of 10 residues composing this site (Gln-133, Asn-249, Val-250, Asp-251, Val-252, Asn-253 and Glu-254) are obligatory components of the dinitroanilines" binding site on the plant alpha-tubulin surface.	Asparagine	91-94	tubulin alpha-5	Arabidopsis thaliana	188-201
24379646-4	2013	Direct sequencing revealed a heterozygous G&gt;A transversion at c.1042 of the coding sequence in exon 7 of BFSP1 (c.1042G&gt;A) in all affected members, which resulted in the substitution of a wild-type aspartate to an asparagine (D348N).	Asparagine	220-230	beaded filament structural protein 1	Homo sapiens	108-113
24379646-6	2013	CONCLUSIONS: A novel mutation (c.1042G&gt;A) at exon 7 of BFSP1, which creates a substitution of an aspartate to an asparagine (p.D348N) was identified to be associated with autosomal dominant congenital cataract in a Chinese family.	Asparagine	116-126	beaded filament structural protein 1	Homo sapiens	58-63
23982874-7	2014	Molecular simulation and docking studies revealed that the amino acids Asn-117 and Asn-121, Glu-249, Cys-302, and Gln-350, present in the active site of human ALDH1A1, played a vital role in interacting with the drug.	Asparagine	71-74	aldehyde dehydrogenase 1 family member A1	Homo sapiens	159-166
23982874-7	2014	Molecular simulation and docking studies revealed that the amino acids Asn-117 and Asn-121, Glu-249, Cys-302, and Gln-350, present in the active site of human ALDH1A1, played a vital role in interacting with the drug.	Asparagine	83-86	aldehyde dehydrogenase 1 family member A1	Homo sapiens	159-166
24320932-12	2013	Thus, these findings indicate that the two highly conserved amino acid residues, Asn and Phe, play an important role in ABCG1-dependent export of cellular cholesterol, mainly through the regulation of ABCG1 trafficking.	Asparagine	81-84	ATP binding cassette subfamily G member 1	Homo sapiens	120-125
24320932-12	2013	Thus, these findings indicate that the two highly conserved amino acid residues, Asn and Phe, play an important role in ABCG1-dependent export of cellular cholesterol, mainly through the regulation of ABCG1 trafficking.	Asparagine	81-84	ATP binding cassette subfamily G member 1	Homo sapiens	201-206
23835327-4	2013	We demonstrate that posttranslational glycosylation of specific extracellular asparagine residues in Ca(V)3.2 channels accelerates current kinetics, increases current density, and augments channel membrane expression.	Asparagine	78-88	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	101-109
24303013-0	2013	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	Asparagine	33-43	asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)	Mus musculus	70-76
24303013-4	2013	A missense mutation in a highly-conserved amino acid was found in the asparagine-linked glycosylation 10B gene (Alg10b), which is within the critical interval for the nse5 mutation.	Asparagine	70-80	asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)	Mus musculus	112-118
24085305-9	2013	Consistent with this, mass spectrometric analysis of the mammalian rLILRA3 revealed canonical N-glycosylation at the predicted Asn(140), Asn(281), Asn(302), Asn(341), and Asn(431) sites.	Asparagine	127-130	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Rattus norvegicus	67-74
24085305-9	2013	Consistent with this, mass spectrometric analysis of the mammalian rLILRA3 revealed canonical N-glycosylation at the predicted Asn(140), Asn(281), Asn(302), Asn(341), and Asn(431) sites.	Asparagine	137-140	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Rattus norvegicus	67-74
24085305-9	2013	Consistent with this, mass spectrometric analysis of the mammalian rLILRA3 revealed canonical N-glycosylation at the predicted Asn(140), Asn(281), Asn(302), Asn(341), and Asn(431) sites.	Asparagine	137-140	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Rattus norvegicus	67-74
24085305-9	2013	Consistent with this, mass spectrometric analysis of the mammalian rLILRA3 revealed canonical N-glycosylation at the predicted Asn(140), Asn(281), Asn(302), Asn(341), and Asn(431) sites.	Asparagine	137-140	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Rattus norvegicus	67-74
24085305-9	2013	Consistent with this, mass spectrometric analysis of the mammalian rLILRA3 revealed canonical N-glycosylation at the predicted Asn(140), Asn(281), Asn(302), Asn(341), and Asn(431) sites.	Asparagine	137-140	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Rattus norvegicus	67-74
24105266-1	2013	Asparagine-linked glycosylation of proteins by the oligosaccharyltransferase (OST) occurs when acceptor sites or sequons (N-x P-T/S) on nascent polypeptides enter the lumen of the rough endoplasmic reticulum.	Asparagine	0-10	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	51-76
24105266-1	2013	Asparagine-linked glycosylation of proteins by the oligosaccharyltransferase (OST) occurs when acceptor sites or sequons (N-x P-T/S) on nascent polypeptides enter the lumen of the rough endoplasmic reticulum.	Asparagine	0-10	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	78-81
24278346-5	2013	Alanine scanning mutagenesis of conserved amino acids in characteristic motifs in p60 revealed that some mutations significantly reduced RNA synthesis but mutating the second asparagine residue in the conserved GDD box was lethal.	Asparagine	175-185	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	82-85
24244460-5	2013	Here, we show that inducible overexpression of ARR22 in Arabidopsis enhanced dehydration, drought, and cold tolerance in a dexamethasone-dependent manner, whereas mutation of the putative phospho-accepting Asp to Asn in ARR22 (ARR22(D74N)) abolished these tolerance phenotypes.	Asparagine	213-216	response regulator 22	Arabidopsis thaliana	47-52
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Asparagine	35-38	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	21-24
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Asparagine	35-38	cyclin dependent kinase 5	Homo sapiens	108-112
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Asparagine	35-38	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	150-153
23765399-2	2013	METHODS: Functionalized SWNTs with polymerised polymeric poly(ethylene imine) was linked NGR (Asn-Gly-Arg) tumor-targeting peptide by DSPE-PEG2000-Maleimide via the maleimide group and sulfhydryl group of cysteine, in the end, doxorubicin (DOX) was attached to SWNT-PEI to obtain a SWNT-PEI/DOX/NGR delivery system.	Asparagine	94-97	reticulon 4 receptor	Homo sapiens	89-92
23996627-8	2013	Such relationships are not so evident in domestic mammals; however, at least one missense substitution (298Asp &gt; Asn) in the porcine MC4R significantly contributes, at least in some breeds, to fat tissue accumulation, feed conversion ratio and daily weight gain.	Asparagine	116-119	melanocortin 4 receptor	Homo sapiens	136-140
23765399-2	2013	METHODS: Functionalized SWNTs with polymerised polymeric poly(ethylene imine) was linked NGR (Asn-Gly-Arg) tumor-targeting peptide by DSPE-PEG2000-Maleimide via the maleimide group and sulfhydryl group of cysteine, in the end, doxorubicin (DOX) was attached to SWNT-PEI to obtain a SWNT-PEI/DOX/NGR delivery system.	Asparagine	94-97	reticulon 4 receptor	Homo sapiens	295-298
24167601-2	2013	Two polymorphisms of the FSHR gene were identified, which caused a change of threonine (T) to alanine (A) at position 307 and asparagine (N) to serine(S) at position 680.	Asparagine	126-136	follicle stimulating hormone receptor	Homo sapiens	25-29
24066782-1	2013	The reactivity of asparagine residues in Cu, Zn superoxide dismutase (SOD1) to deamidate to aspartate remains uncharacterized; its occurrence in SOD1 has not been investigated, and the biophysical effects of deamidation on SOD1 are unknown.	Asparagine	18-28	superoxide dismutase 1	Homo sapiens	70-74
24066782-1	2013	The reactivity of asparagine residues in Cu, Zn superoxide dismutase (SOD1) to deamidate to aspartate remains uncharacterized; its occurrence in SOD1 has not been investigated, and the biophysical effects of deamidation on SOD1 are unknown.	Asparagine	18-28	superoxide dismutase 1	Homo sapiens	145-149
24066782-1	2013	The reactivity of asparagine residues in Cu, Zn superoxide dismutase (SOD1) to deamidate to aspartate remains uncharacterized; its occurrence in SOD1 has not been investigated, and the biophysical effects of deamidation on SOD1 are unknown.	Asparagine	18-28	superoxide dismutase 1	Homo sapiens	145-149
24066782-2	2013	Deamidation is, nonetheless, chemically equivalent to Asn-to-Asp missense mutations in SOD1 that cause amyotrophic lateral sclerosis (ALS).	Asparagine	54-57	superoxide dismutase 1	Homo sapiens	87-91
24066782-3	2013	This study utilized computational methods to identify three asparagine residues in wild-type (WT) SOD1 (i.e., N26, N131, and N139) that are predicted to undergo significant deamidation (i.e., to >20%) on time scales comparable to the long lifetime (>1 year) of SOD1 in large motor neurons.	Asparagine	60-70	superoxide dismutase 1	Homo sapiens	98-102
24066782-3	2013	This study utilized computational methods to identify three asparagine residues in wild-type (WT) SOD1 (i.e., N26, N131, and N139) that are predicted to undergo significant deamidation (i.e., to >20%) on time scales comparable to the long lifetime (>1 year) of SOD1 in large motor neurons.	Asparagine	60-70	superoxide dismutase 1	Homo sapiens	261-265
24066782-4	2013	Site-directed mutagenesis was used to successively substitute these asparagines with aspartate (to mimic deamidation) according to their predicted deamidation rate, yielding: N26D, N26D/N131D, and N26D/N131D/N139D SOD1.	Asparagine	68-79	superoxide dismutase 1	Homo sapiens	214-218
24066782-9	2013	The deamidation of asparagine--an analytically elusive, sub-Dalton modification--represents a plausible and overlooked mechanism by which WT SOD1 is converted to a neurotoxic isoform that has a similar structure, instability, and aggregation propensity as ALS mutant N139D SOD1.	Asparagine	19-29	superoxide dismutase 1	Homo sapiens	141-145
24066782-9	2013	The deamidation of asparagine--an analytically elusive, sub-Dalton modification--represents a plausible and overlooked mechanism by which WT SOD1 is converted to a neurotoxic isoform that has a similar structure, instability, and aggregation propensity as ALS mutant N139D SOD1.	Asparagine	19-29	superoxide dismutase 1	Homo sapiens	273-277
24019527-3	2013	NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with P97/VCP on its positively charged VCP binding motif.	Asparagine	81-84	negative regulator of ubiquitin like proteins 1	Homo sapiens	0-5
24019527-3	2013	NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with P97/VCP on its positively charged VCP binding motif.	Asparagine	81-84	NEDD8 ubiquitin like modifier	Homo sapiens	31-36
23937634-2	2013	Glycosylation (with a single GlcNAc) of the reverse turn sequence Phe-Yyy-Asn-Xxx-Thr at Asn stabilizes the Pin 1 WW domain by -0.85 +- 0.12 kcal mol(-1).	Asparagine	74-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	108-113
24014025-4	2013	We discovered that secreted LOXL2 (~100-kDa) is N-glycosylated at Asn-455 and Asn-644, whereas intracellular LOXL2 (~75-kDa) is nonglycosylated and N-terminally processed, and is primarily associated with the nucleus.	Asparagine	66-69	lysyl oxidase like 2	Homo sapiens	28-33
24014025-4	2013	We discovered that secreted LOXL2 (~100-kDa) is N-glycosylated at Asn-455 and Asn-644, whereas intracellular LOXL2 (~75-kDa) is nonglycosylated and N-terminally processed, and is primarily associated with the nucleus.	Asparagine	78-81	lysyl oxidase like 2	Homo sapiens	28-33
24139043-5	2013	ASNS encodes asparagine synthetase, which catalyzes the synthesis of asparagine from glutamine and aspartate.	Asparagine	13-23	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-4
23791648-3	2013	Sequencing of ALPL identified two genetic alterations in the probands, including a heterozygous missense mutation c.454C&gt;T, leading to change of arginine 152 to cysteine (p.R152C), and a novel heterozygous gene deletion c.1318_1320delAAC, leading to the loss of an asparagine residue at codon 440 (p.N440del).	Asparagine	268-278	alkaline phosphatase, biomineralization associated	Homo sapiens	14-18
24053334-3	2013	These structures reveal that interactions between the ligands and Asn 64, Phe 31, and Phe 34 are important for increased affinity for human DHFR and that loop residues 58-64 undergo ligand-induced conformational changes.	Asparagine	66-69	dihydrofolate reductase	Homo sapiens	140-144
24053334-7	2013	Likewise, comparisons of human and Candida glabrata DHFR bound to the same ligand show that hydrophobic interactions with residues Ile 121 and Phe 66 (Val 115 and Asn 64 in human DHFR) yield selective inhibitors.	Asparagine	163-166	dihydrofolate reductase	Homo sapiens	52-56
24053334-7	2013	Likewise, comparisons of human and Candida glabrata DHFR bound to the same ligand show that hydrophobic interactions with residues Ile 121 and Phe 66 (Val 115 and Asn 64 in human DHFR) yield selective inhibitors.	Asparagine	163-166	dihydrofolate reductase	Homo sapiens	179-183
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Asparagine	109-119	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-39
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Asparagine	109-119	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	41-45
23953588-20	2013	FSHR expression at the transcript level was observed to be significantly lower in women with A/A-Asn/Asn genotype as compared to women with G/G-Asn/Ser genotype.	Asparagine	97-100	follicle stimulating hormone receptor	Homo sapiens	0-4
23697717-8	2013	Fasting insulin was related with 3-methylhistidine, Asparagine, Alanine, gamma-aminobutyric acid and Cystathionine.	Asparagine	52-62	insulin	Homo sapiens	8-15
23921072-6	2013	LC-MS analysis confirmed that full-length melanopsin-L was expressed and demonstrated that the majority of the expressed protein was N-glycosylated at Asn(30) and Asn(34).	Asparagine	151-154	opsin 4 (melanopsin)	Mus musculus	42-52
23921072-6	2013	LC-MS analysis confirmed that full-length melanopsin-L was expressed and demonstrated that the majority of the expressed protein was N-glycosylated at Asn(30) and Asn(34).	Asparagine	163-166	opsin 4 (melanopsin)	Mus musculus	42-52
23977265-8	2013	However, the XPD 312Asn allele was significantly associated with poor response to Pt-chemotherapy compared with the Asp312 allele (Asn vs. Asp: OR = 0.435, 95% CI: 0.261-0.726).	Asparagine	20-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	13-16
23942113-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	annexin A2	Bos taurus	42-52
23942113-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	legumain	Bos taurus	92-100
23942113-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in vivo.	Asparagine	151-154	annexin A2	Bos taurus	134-144
23818223-1	2013	Recently, we characterized multiple roles of the endoplasmic reticulum stress responsive element (ERSE) in the promotion of a unique head-to-head gene pair: mammalian asparagine-linked glycosylation 12 homolog (ALG12) and cysteine-rich with EGF-like domains 2 (CRELD2).	Asparagine	167-177	ALG12 alpha-1,6-mannosyltransferase	Homo sapiens	211-216
23818223-1	2013	Recently, we characterized multiple roles of the endoplasmic reticulum stress responsive element (ERSE) in the promotion of a unique head-to-head gene pair: mammalian asparagine-linked glycosylation 12 homolog (ALG12) and cysteine-rich with EGF-like domains 2 (CRELD2).	Asparagine	167-177	cysteine rich with EGF like domains 2	Homo sapiens	222-259
23818223-1	2013	Recently, we characterized multiple roles of the endoplasmic reticulum stress responsive element (ERSE) in the promotion of a unique head-to-head gene pair: mammalian asparagine-linked glycosylation 12 homolog (ALG12) and cysteine-rich with EGF-like domains 2 (CRELD2).	Asparagine	167-177	cysteine rich with EGF like domains 2	Homo sapiens	261-267
26592411-5	2013	The simulations show that acetyl-lysine has two major binding modes in TAF1(2) one of which corresponds to the available crystal structures and is stabilized by a hydrogen bond to the conserved Asn side chain.	Asparagine	194-197	TATA-box binding protein associated factor 12	Homo sapiens	71-77
23601492-5	2013	We confirmed that MucoRice-CTB/Q produces a single CTB monomer with an Asn to Gln substitution at the 4th glycosylation position.	Asparagine	71-74	phosphate cytidylyltransferase 1B, choline	Homo sapiens	27-30
23601492-5	2013	We confirmed that MucoRice-CTB/Q produces a single CTB monomer with an Asn to Gln substitution at the 4th glycosylation position.	Asparagine	71-74	phosphate cytidylyltransferase 1B, choline	Homo sapiens	51-54
23650190-6	2013	Strikingly, NIS with the sequence 439-AANAA-443, in which Asn was restored at position 441, was targeted to the plasma membrane and exhibited ~95% the transport activity of WT NIS.	Asparagine	58-61	solute carrier family 5 member 5	Homo sapiens	12-15
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	136-139	C-X-C motif chemokine ligand 12	Homo sapiens	38-44
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	136-139	C-X-C motif chemokine receptor 4	Homo sapiens	233-238
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	136-139	atypical chemokine receptor 3	Homo sapiens	243-248
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	144-147	C-X-C motif chemokine ligand 12	Homo sapiens	38-44
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	144-147	C-X-C motif chemokine receptor 4	Homo sapiens	233-238
23812669-11	2013	A crystal structure of the hu30D8 Fab/CXCL12alpha complex in combination with mutational analysis revealed a "hot spot" around residues Asn(44)/Asn(45) of CXCL12alpha and part of the RFFESH region required for CXCL12alpha binding to CXCR4 and CXCR7.	Asparagine	144-147	atypical chemokine receptor 3	Homo sapiens	243-248
23770703-3	2013	Indeed, in (HUMAN)NAT2 variants, mutation of the Asp residue to Asn, Gln, or Glu dramatically impairs enzyme activity.	Asparagine	64-67	N-acetyltransferase 2	Homo sapiens	18-22
23179090-9	2013	Asparagine was found to be indicative of healthiness of cells and production of high IGF-1.	Asparagine	0-10	insulin-like growth factor I	Cricetulus griseus	85-90
23763375-0	2013	Contribution of asparagine 346 residue to the carbapenemase activity of CMY-2 beta-lactamase.	Asparagine	16-26	CMY-2 beta-lactamase	Escherichia coli	72-92
23650190-6	2013	Strikingly, NIS with the sequence 439-AANAA-443, in which Asn was restored at position 441, was targeted to the plasma membrane and exhibited ~95% the transport activity of WT NIS.	Asparagine	58-61	solute carrier family 5 member 5	Homo sapiens	176-179
23503728-0	2013	Surface expression and function of Cav3.2 T-type calcium channels are controlled by asparagine-linked glycosylation.	Asparagine	84-94	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	35-41
23698308-2	2013	Upon central nervous system (CNS) infection, Env is expressed as multiple isoforms owing to differential asparagine (N)-linked glycosylation.	Asparagine	105-115	endogenous retrovirus group K member 6, envelope	Homo sapiens	45-48
23785214-12	2013	We further showed that asparagine at position 195 in HTLV-1 SU is involved in determining this CD4(+) T cell immortalization tropism.	Asparagine	23-33	CD4 molecule	Homo sapiens	95-98
23503728-3	2013	In the present study, we looked at the role of asparagine (N)-linked glycosylation on human Cav3.2 T-type channel expression and function.	Asparagine	47-57	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	92-98
23503728-5	2013	Using site-directed mutagenesis to disrupt the canonical N-linked glycosylation sites of Cav3.2 channel, we show that glycosylation at asparagine N192 is critical for channel expression at the surface, whereas glycosylation at asparagine N1466 controls channel activity.	Asparagine	135-145	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	89-95
23503728-5	2013	Using site-directed mutagenesis to disrupt the canonical N-linked glycosylation sites of Cav3.2 channel, we show that glycosylation at asparagine N192 is critical for channel expression at the surface, whereas glycosylation at asparagine N1466 controls channel activity.	Asparagine	227-237	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	89-95
23294335-21	2013	However, all yeast prions studied by solid state NMR (Sup35p, Ure2p, and Rnq1p) have in-register parallel beta-sheet structures, with their Gln- and Asn-rich N-terminal segments forming the fibril core.	Asparagine	149-152	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	54-60
23394253-13	2013	Homozygotes Asn/Asn tended to have higher rhFSH-induced expression of FSHR as compared to the carriers of Ser/Ser genotype.	Asparagine	12-15	follicle stimulating hormone receptor	Homo sapiens	70-74
23394253-13	2013	Homozygotes Asn/Asn tended to have higher rhFSH-induced expression of FSHR as compared to the carriers of Ser/Ser genotype.	Asparagine	16-19	follicle stimulating hormone receptor	Homo sapiens	70-74
23740269-4	2013	GGT AAT substitution resulted in Gly Asn change inside the zinc-finger motif in the capsid protein was revealed specific for discrimination of the clusters and we hypothesise that could influence the host preference.	Asparagine	37-40	serpin family A member 1	Homo sapiens	4-7
23294335-21	2013	However, all yeast prions studied by solid state NMR (Sup35p, Ure2p, and Rnq1p) have in-register parallel beta-sheet structures, with their Gln- and Asn-rich N-terminal segments forming the fibril core.	Asparagine	149-152	prion domain-containing protein RNQ1	Saccharomyces cerevisiae S288C	73-78
23535574-14	2013	The U83BA-NT asparagine-lysine14 substitution disrupted activity, thus defining CCR2 specificity and acting as a main determinant for HHV-6A/B differences in cellular interactions.	Asparagine	13-23	C-C motif chemokine receptor 2	Homo sapiens	80-84
23776238-3	2013	The B-cell maturation antigen (BCMA), an essential membrane protein for maintaining the survival of plasma cells, was identified as a glycoprotein exhibiting complex-type N-glycans at a single N-glycosylation site, asparagine 42.	Asparagine	215-225	TNF receptor superfamily member 17	Homo sapiens	4-29
23776238-3	2013	The B-cell maturation antigen (BCMA), an essential membrane protein for maintaining the survival of plasma cells, was identified as a glycoprotein exhibiting complex-type N-glycans at a single N-glycosylation site, asparagine 42.	Asparagine	215-225	TNF receptor superfamily member 17	Homo sapiens	31-35
23680598-3	2013	TDG interacts with the carboxylate moiety of target nucleotide 5caC using the side chain of asparagine 230 (N230), instead of asparagine 157 (N157) as previously reported.	Asparagine	92-102	thymine DNA glycosylase	Homo sapiens	0-3
23680598-3	2013	TDG interacts with the carboxylate moiety of target nucleotide 5caC using the side chain of asparagine 230 (N230), instead of asparagine 157 (N157) as previously reported.	Asparagine	126-136	thymine DNA glycosylase	Homo sapiens	0-3
23680598-5	2013	Combination of both the asparagine-to-aspartate mutations (N157D/N230D) resulted in complete loss of activity on G:5caC while retaining measurable activity on G:U, implying that 5caC can adopt alternative conformations (either N157-interacting or N230-interacting) in the TDG active site to interact with either of the two asparagine side chain for 5caC excision.	Asparagine	24-34	thymine DNA glycosylase	Homo sapiens	272-275
23709217-5	2013	However, mutation of a highly conserved asparagine (Asn-550) in TM3 allowed Dnf1 to restore plasma membrane PS asymmetry in a strain deficient for the P4-ATPase Drs2, the primary PS flippase.	Asparagine	40-50	tropomyosin 3	Homo sapiens	64-67
23709217-5	2013	However, mutation of a highly conserved asparagine (Asn-550) in TM3 allowed Dnf1 to restore plasma membrane PS asymmetry in a strain deficient for the P4-ATPase Drs2, the primary PS flippase.	Asparagine	52-55	tropomyosin 3	Homo sapiens	64-67
23709217-5	2013	However, mutation of a highly conserved asparagine (Asn-550) in TM3 allowed Dnf1 to restore plasma membrane PS asymmetry in a strain deficient for the P4-ATPase Drs2, the primary PS flippase.	Asparagine	52-55	dishevelled segment polarity protein 1	Homo sapiens	161-165
23688511-10	2013	Substitution of the asparagine at position 417 with structurally related amino acids such as an aspartate and a glutamine also abolished the dimerization of TNSALP without perturbing its cell surface localization.	Asparagine	20-30	alkaline phosphatase, biomineralization associated	Homo sapiens	157-163
23688511-0	2013	An asparagine at position 417 of tissue-nonspecific alkaline phosphatase is essential for its structure and function as revealed by analysis of the N417S mutation associated with severe hypophosphatasia.	Asparagine	3-13	alkaline phosphatase, biomineralization associated	Homo sapiens	33-72
23688511-11	2013	Taken together, the asparagine at position 417 is crucial for the assembly and function of TNSALP, which may explain the severity of the N417S mutation.	Asparagine	20-30	alkaline phosphatase, biomineralization associated	Homo sapiens	91-97
23688511-2	2013	A point mutation (c.1250A&gt;G), which leads to replacement of an asparagine at position 417 of TNSALP with serine [TNSALP (N417S)], has been reported in a patient diagnosed with perinatal HPP (Sergi C. et al.	Asparagine	66-76	alkaline phosphatase, biomineralization associated	Homo sapiens	96-102
23688511-2	2013	A point mutation (c.1250A&gt;G), which leads to replacement of an asparagine at position 417 of TNSALP with serine [TNSALP (N417S)], has been reported in a patient diagnosed with perinatal HPP (Sergi C. et al.	Asparagine	66-76	alkaline phosphatase, biomineralization associated	Homo sapiens	116-122
23671108-2	2013	IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by fragment crystallizable-fragment crystallizable (Fc-Fc) interactions.	Asparagine	51-61	endo-beta-N-acetylglucosaminidase	Mus musculus	94-127
24257358-6	2013	All affected individuals were detected with TUBB3 c.1249G &gt; A mutation, the mutation is in exon 4, resulting in wild-type gene encoding the Aspartic acid ( Asp or D ) replaced .by Asparagine (Asn or N ).	Asparagine	183-193	tubulin beta 3 class III	Homo sapiens	44-49
24257358-6	2013	All affected individuals were detected with TUBB3 c.1249G &gt; A mutation, the mutation is in exon 4, resulting in wild-type gene encoding the Aspartic acid ( Asp or D ) replaced .by Asparagine (Asn or N ).	Asparagine	195-198	tubulin beta 3 class III	Homo sapiens	44-49
23661698-2	2013	The crystal structure of the ligand-receptor complex revealed a glycosylation on the Asn-26 of ephrin-A1.	Asparagine	85-88	ephrin A1	Homo sapiens	95-104
24079222-1	2013	Aspargine-glycine-arginine (NGR)-containing peptides are targeted peptides which can be integrated with CD13 receptors on tumor vascular endothelial cells.	Asparagine	0-9	reticulon 4 receptor	Homo sapiens	28-31
24079222-1	2013	Aspargine-glycine-arginine (NGR)-containing peptides are targeted peptides which can be integrated with CD13 receptors on tumor vascular endothelial cells.	Asparagine	0-9	alanyl aminopeptidase, membrane	Homo sapiens	104-108
23757024-3	2013	AtGLR3.4, a plant iGluR homolog from Arabidopsis thaliana, has ion channel activity and is gated by asparagine, serine, and glycine.	Asparagine	100-110	glutamate receptor 3.4	Arabidopsis thaliana	0-8
23640887-3	2013	In acidic conditions such as generated by brain ischemia and hypoxia, especially in association with hyperglycemia as in diabetes, I2(PP2A) is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I2NTF) and the C-terminal fragment (I2CTF).	Asparagine	183-186	protein phosphatase 2 phosphatase activator	Homo sapiens	131-138
23640887-3	2013	In acidic conditions such as generated by brain ischemia and hypoxia, especially in association with hyperglycemia as in diabetes, I2(PP2A) is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I2NTF) and the C-terminal fragment (I2CTF).	Asparagine	183-186	legumain	Homo sapiens	154-179
23714211-3	2013	Intercellular adhesion molecule-2 (ICAM-2), a member of the immunoglobulin superfamily of CAMs, has six N-linked glycosylation sites at amino acids (asparagines) 47, 82, 105, 153, 178 and 187.	Asparagine	149-160	intercellular adhesion molecule 2	Mus musculus	0-33
23633098-1	2013	Expression of Bombyx mori Asparagine synthetase (BmASNS), one gene that encodes an enzyme catalyzing asparagine biosynthesis, is transcriptionally induced following amino acid deprivation.	Asparagine	101-111	asparagine synthetase	Bombyx mori	26-47
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiogenin	Homo sapiens	0-3
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiotensin II receptor type 1	Homo sapiens	13-16
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiotensin II receptor type 2	Homo sapiens	21-24
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiotensin II receptor type 1	Homo sapiens	111-114
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiogenin	Homo sapiens	149-152
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Asparagine	116-119	angiogenin	Homo sapiens	149-152
23755216-9	2013	In both AT1 and AT2, the Ang II peptide may internalize through Phe (8) of Ang II propagating through the receptors" conserved aromatic amino acids to the final photolabled positioning relative to either AT1 (amino acid 294, Asn, consensus 725) or AT2 (138, Leu, consensus 336).	Asparagine	225-228	angiogenin	Homo sapiens	25-28
23714211-3	2013	Intercellular adhesion molecule-2 (ICAM-2), a member of the immunoglobulin superfamily of CAMs, has six N-linked glycosylation sites at amino acids (asparagines) 47, 82, 105, 153, 178 and 187.	Asparagine	149-160	intercellular adhesion molecule 2	Mus musculus	35-41
23714211-11	2013	We used site-directed mutagenesis to express hypo- or non-glycosylated variants of ICAM-2, by substituting alanine for asparagine at glycosylation sites, and compared the impact of each variant on NB cell motility, anchorage-independent growth, interaction with intracellular proteins, effect on F-actin distribution and metastatic potential in vivo.	Asparagine	119-129	intercellular adhesion molecule 2	Mus musculus	83-89
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Asparagine	148-151	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Asparagine	148-151	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
23678519-20	2004	A cyclic heptapeptide, cyclo(Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys) (R832), was identified with phage screening against VCAM-1 (12).	Asparagine	33-36	vascular cell adhesion molecule 1	Mus musculus	118-124
23541716-8	2013	Additionally, three novel PTMs in ITIH3 were identified and include hexose-N-acetyl-hexosamine at asparagine-(41), trimethylation at aspartic acid-(290), and flavin adenine dinucleotide at histidine-(335).	Asparagine	98-108	inter-alpha-trypsin inhibitor heavy chain 3	Homo sapiens	34-39
23556518-4	2013	Human TfR2 (hTfR2) contains four potential Asn-linked (N-linked) glycosylation sites on its ectodomain.	Asparagine	43-46	transferrin receptor 2	Homo sapiens	6-10
23556518-4	2013	Human TfR2 (hTfR2) contains four potential Asn-linked (N-linked) glycosylation sites on its ectodomain.	Asparagine	43-46	transferrin receptor 2	Homo sapiens	12-17
23556518-6	2013	In this study, by employing site-directed mutagenesis to remove glycosylation sites of hTfR2 individually or in combination, we found that hTfR2 was glycosylated at Asn 240, 339, and 754, while the consensus sequence for N-linked glycosylation at Asn 540 was not utilized.	Asparagine	165-168	transferrin receptor 2	Homo sapiens	139-144
23556518-6	2013	In this study, by employing site-directed mutagenesis to remove glycosylation sites of hTfR2 individually or in combination, we found that hTfR2 was glycosylated at Asn 240, 339, and 754, while the consensus sequence for N-linked glycosylation at Asn 540 was not utilized.	Asparagine	247-250	transferrin receptor 2	Homo sapiens	139-144
23578107-5	2013	Here we show that appending a short PEG oligomer to a single Asn side chain within a reverse turn in the WW domain of the human protein Pin 1 increases WW conformational stability in a manner that depends strongly on the length of the PEG oligomer: shorter oligomers increase folding rate, whereas longer oligomers increase folding rate and reduce unfolding rate.	Asparagine	61-64	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	136-141
23585457-3	2013	l-asparaginase (ASNase) is a first-line therapy for ALL that breaks down asparagine and glutamine, exploiting the fact that ALL cells are more dependent on these amino acids than other cells.	Asparagine	73-83	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
23585457-3	2013	l-asparaginase (ASNase) is a first-line therapy for ALL that breaks down asparagine and glutamine, exploiting the fact that ALL cells are more dependent on these amino acids than other cells.	Asparagine	73-83	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
23550158-7	2013	Immunoprecipitation and proteomic analysis revealed that PSMA1-GFP copurifies with several acrosomal membrane-associated proteins (e.g., lactadherin/milk fat globule E8 and spermadhesin alanine-tryptophan-asparagine).	Asparagine	205-215	proteasome 20S subunit alpha 1	Homo sapiens	57-62
23403946-1	2013	Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Asparagine	84-94	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
23403946-1	2013	Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Asparagine	84-94	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
23582646-5	2013	Modeling of TUBB4A shows that the mutation creates a nonsynonymous change at a highly conserved asparagine that sits at the intradimer interface of alpha-tubulin and beta-tubulin, and this change might affect tubulin dimerization, microtubule polymerization, or microtubule stability.	Asparagine	96-106	tubulin beta 4A class IVa	Homo sapiens	12-18
23582646-5	2013	Modeling of TUBB4A shows that the mutation creates a nonsynonymous change at a highly conserved asparagine that sits at the intradimer interface of alpha-tubulin and beta-tubulin, and this change might affect tubulin dimerization, microtubule polymerization, or microtubule stability.	Asparagine	96-106	tubulin alpha 1b	Homo sapiens	148-161
23477942-6	2013	Interestingly, the Glc-Asn linked glycopeptide was completely resistant to PNGase F digestion, in contrast to the GlcNAc-Asn linked natural glycopeptide that is an excellent substrate for hydrolysis.	Asparagine	23-26	N-glycanase 1	Homo sapiens	75-81
23333196-7	2013	Sequencing of exon 2 of the TAP gene from 23 cattle revealed a prevalent non-synonymous single nucleotide polymorphism (SNP) A137G, encoding either serine or asparagine at residue 20 of the mature peptide.	Asparagine	158-168	tracheal antimicrobial peptide	Bos taurus	28-31
23422691-8	2013	Furthermore, substitution of asparagine at the VEGF glycosylation site with lysine or glutamic acid increased secretion of non-glycosylated VEGF, a finding not previously reported.	Asparagine	29-39	vascular endothelial growth factor A	Homo sapiens	47-51
23422691-8	2013	Furthermore, substitution of asparagine at the VEGF glycosylation site with lysine or glutamic acid increased secretion of non-glycosylated VEGF, a finding not previously reported.	Asparagine	29-39	vascular endothelial growth factor A	Homo sapiens	140-144
23535599-6	2013	Mass spectrometry showed that IpaJ cleaved the peptide bond between N-myristoylated glycine-2 and asparagine-3 of human ARF1, thereby providing a new mechanism for host secretory inhibition by a bacterial pathogen.	Asparagine	98-108	ADP ribosylation factor 1	Homo sapiens	120-124
23420846-3	2013	An asparagine residue (Asn-106) in transmembrane segment 2 of AHA2 is conserved in all P-type plasma membrane H(+)-ATPases.	Asparagine	3-13	H[+]-ATPase 2	Arabidopsis thaliana	62-66
23420846-3	2013	An asparagine residue (Asn-106) in transmembrane segment 2 of AHA2 is conserved in all P-type plasma membrane H(+)-ATPases.	Asparagine	23-26	H[+]-ATPase 2	Arabidopsis thaliana	62-66
23530066-1	2013	Metazoan organisms assemble two isoforms of the oligosaccharyltransferase (OST) that have different catalytic subunits (STT3A or STT3B) and partially nonoverlapping roles in asparagine-linked glycosylation.	Asparagine	174-184	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	48-73
23344882-8	2013	Thereby, the isomerization of Asn at neutral pH (0.6 day(-1), peptide NGEF) is approximately six times faster than that within the peptide chain (AANGEF).	Asparagine	30-33	neuronal guanine nucleotide exchange factor	Homo sapiens	70-74
23344882-8	2013	Thereby, the isomerization of Asn at neutral pH (0.6 day(-1), peptide NGEF) is approximately six times faster than that within the peptide chain (AANGEF).	Asparagine	30-33	neuronal guanine nucleotide exchange factor	Homo sapiens	146-152
23771356-10	2013	CONCLUSION: These findings indicated that the Asn allele of XPD Asp312Asn might be a risk-factor for developing prostate cancer among Asian and African men but protective for Caucasian population.	Asparagine	46-49	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	60-63
23398626-3	2013	In the present investigation, an improved method for screening of the microorganisms producing extracellular l-asparaginase is reported wherein bromothymol blue (BTB) is incorporated as pH indicator in l-asparagine-containing medium instead of phenol red.	Asparagine	202-214	asparaginase and isoaspartyl peptidase 1	Homo sapiens	109-123
23530066-1	2013	Metazoan organisms assemble two isoforms of the oligosaccharyltransferase (OST) that have different catalytic subunits (STT3A or STT3B) and partially nonoverlapping roles in asparagine-linked glycosylation.	Asparagine	174-184	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	75-78
23530066-1	2013	Metazoan organisms assemble two isoforms of the oligosaccharyltransferase (OST) that have different catalytic subunits (STT3A or STT3B) and partially nonoverlapping roles in asparagine-linked glycosylation.	Asparagine	174-184	STT3 oligosaccharyltransferase complex catalytic subunit B	Homo sapiens	129-134
23625227-12	2013	We found that MICB*008 which contains methionine and asparagine at the amino acid positions 98 and 113, respectively, in the alpha 2 domain showed decreased binding activities to UL16 when compared to MICB*003, 004, and MICB*00502 containing isoleucine and aspartic acid, respectively.	Asparagine	53-63	MHC class I polypeptide-related sequence B	Homo sapiens	14-18
23503366-3	2013	Biochemical analyses based on structural information suggest that Atg3 requires a threonine residue to catalyze the conjugation reaction instead of the typical asparagine residue used by other E2 enzymes.	Asparagine	160-170	Atg3p	Saccharomyces cerevisiae S288C	66-70
23521865-4	2013	RESULTS: We identified three individuals homozygous for a novel six base pair in-frame deletion in LYST (c.9827_9832ATACAA), predicting the loss of asparagine and threonine residues from the LYST transcript (p.Asn3276_Thr3277del), and segregating with the phenotype in this family.	Asparagine	148-158	lysosomal trafficking regulator	Homo sapiens	99-103
23337108-2	2013	In the previously solved structure of TDG in complex with DNA containing 5caC, the side chain of asparagine 157 (N157) contacts the 5-carboxyl moiety of 5caC via a weak hydrogen bond.	Asparagine	97-107	thymine DNA glycosylase	Homo sapiens	38-41
23521865-4	2013	RESULTS: We identified three individuals homozygous for a novel six base pair in-frame deletion in LYST (c.9827_9832ATACAA), predicting the loss of asparagine and threonine residues from the LYST transcript (p.Asn3276_Thr3277del), and segregating with the phenotype in this family.	Asparagine	148-158	lysosomal trafficking regulator	Homo sapiens	191-195
23341449-6	2013	Specifically, two basic OCAM Ig5 residues (Lys and Arg) found near asparagines equivalent to those carrying the polysialylated N-glycans in NCAM substantially decrease or eliminate polysialylation when used to replace the smaller and more neutral residues (Ser and Asn) in analogous positions in NCAM Ig5.	Asparagine	265-268	neural cell adhesion molecule 1	Homo sapiens	140-144
23416356-3	2013	A model of Ost3p and Ost6p function has been proposed in which their thioredoxin-like active site cysteines form transient mixed disulfide bonds with cysteines in substrate proteins to enhance the glycosylation of nearby asparagine residues.	Asparagine	221-231	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Saccharomyces cerevisiae S288C	11-16
23416356-3	2013	A model of Ost3p and Ost6p function has been proposed in which their thioredoxin-like active site cysteines form transient mixed disulfide bonds with cysteines in substrate proteins to enhance the glycosylation of nearby asparagine residues.	Asparagine	221-231	dolichyl-diphosphooligosaccharide--protein glycotransferase	Saccharomyces cerevisiae S288C	21-26
23467356-8	2013	Mapping and sequencing showed that noddy mutant mice harbor an isoleucine-to-asparagine (I108N) mutation in the EC1 repeat of PCDH15.	Asparagine	77-87	protocadherin 15	Mus musculus	126-132
23292652-2	2013	Using structural and biochemical approaches to study the role of the conserved asparagine to ubiquitin conjugation by Ubc13-Mms2, we conclude that the importance of this residue stems primarily from its structural role in stabilizing an active site loop.	Asparagine	79-89	ubiquitin conjugating enzyme E2 N	Homo sapiens	118-123
23305928-1	2013	P450(cin) (CYP176A) is a rare bacterial P450 in that contains an asparagine (Asn242) instead of the conserved threonine that almost all other P450s possess that directs oxygen activation by the heme prosthetic group.	Asparagine	65-75	pyridoxal phosphatase	Homo sapiens	0-9
23404334-5	2013	Through analogy with yeast, ALG14 is thought to form a multiglycosyltransferase complex with ALG13 and DPAGT1 that catalyses the first two committed steps of asparagine-linked protein glycosylation.	Asparagine	158-168	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14	Saccharomyces cerevisiae S288C	28-33
23404334-5	2013	Through analogy with yeast, ALG14 is thought to form a multiglycosyltransferase complex with ALG13 and DPAGT1 that catalyses the first two committed steps of asparagine-linked protein glycosylation.	Asparagine	158-168	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13	Saccharomyces cerevisiae S288C	93-98
23404334-5	2013	Through analogy with yeast, ALG14 is thought to form a multiglycosyltransferase complex with ALG13 and DPAGT1 that catalyses the first two committed steps of asparagine-linked protein glycosylation.	Asparagine	158-168	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	103-109
23404334-7	2013	ALG2 is an alpha-1,3-mannosyltransferase that also catalyses early steps in the asparagine-linked glycosylation pathway.	Asparagine	80-90	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	0-4
23404334-9	2013	Identification of DPAGT1, ALG14 and ALG2 mutations as a cause of congenital myasthenic syndrome underscores the importance of asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction.	Asparagine	126-136	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	18-24
23404334-9	2013	Identification of DPAGT1, ALG14 and ALG2 mutations as a cause of congenital myasthenic syndrome underscores the importance of asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction.	Asparagine	126-136	ALG14 UDP-N-acetylglucosaminyltransferase subunit	Homo sapiens	26-31
23404334-9	2013	Identification of DPAGT1, ALG14 and ALG2 mutations as a cause of congenital myasthenic syndrome underscores the importance of asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction.	Asparagine	126-136	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	36-40
23243163-11	2013	Site-directed mutagenesis indicated that a tyrosine residue at position 464 of WT1 increased the 17alpha-hydroxylation of progesterone compared with an asparagine residue at that position of WT2.	Asparagine	152-162	Wilms tumor protein	Ovis aries	79-82
23292652-2	2013	Using structural and biochemical approaches to study the role of the conserved asparagine to ubiquitin conjugation by Ubc13-Mms2, we conclude that the importance of this residue stems primarily from its structural role in stabilizing an active site loop.	Asparagine	79-89	ubiquitin conjugating enzyme E2 V2	Homo sapiens	124-128
23382219-3	2013	The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain.	Asparagine	173-176	sorting nexin 17	Homo sapiens	58-72
23644307-6	2013	More recent findings demonstrating that both TDP-43 and FUS contain glutamine/asparagine (Q/N) residue-rich prion-like domains have spurred intense research interest.	Asparagine	78-88	TAR DNA binding protein	Homo sapiens	45-51
23644307-6	2013	More recent findings demonstrating that both TDP-43 and FUS contain glutamine/asparagine (Q/N) residue-rich prion-like domains have spurred intense research interest.	Asparagine	78-88	FUS RNA binding protein	Homo sapiens	56-59
23319596-8	2013	The N-glycosylation site at Asn-644 in the LOX catalytic domain is not conserved in human LOX (hLOX), although the LOX catalytic domain of hLOX shares ~50% identity and ~70% homology with hLOXL2.	Asparagine	28-31	lysyl oxidase	Homo sapiens	43-46
23319596-8	2013	The N-glycosylation site at Asn-644 in the LOX catalytic domain is not conserved in human LOX (hLOX), although the LOX catalytic domain of hLOX shares ~50% identity and ~70% homology with hLOXL2.	Asparagine	28-31	lysyl oxidase	Homo sapiens	139-143
23319596-8	2013	The N-glycosylation site at Asn-644 in the LOX catalytic domain is not conserved in human LOX (hLOX), although the LOX catalytic domain of hLOX shares ~50% identity and ~70% homology with hLOXL2.	Asparagine	28-31	lysyl oxidase like 2	Homo sapiens	188-194
23319596-10	2013	These results suggest that the N-glycan at Asn-644 of hLOXL2 enhances the solubility and stability of the LOX catalytic domain.	Asparagine	43-46	lysyl oxidase like 2	Homo sapiens	54-60
23319596-10	2013	These results suggest that the N-glycan at Asn-644 of hLOXL2 enhances the solubility and stability of the LOX catalytic domain.	Asparagine	43-46	lysyl oxidase	Homo sapiens	55-58
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Asparagine	144-147	nitric oxide synthase 1	Homo sapiens	30-34
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Asparagine	144-147	nitric oxide synthase 3	Homo sapiens	39-43
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Asparagine	144-147	nitric oxide synthase 1	Homo sapiens	135-139
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Asparagine	144-147	nitric oxide synthase 3	Homo sapiens	151-155
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Asparagine	144-147	nitric oxide synthase 1	Homo sapiens	135-139
23382219-3	2013	The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain.	Asparagine	173-176	sorting nexin 27	Homo sapiens	74-79
23382219-3	2013	The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain.	Asparagine	173-176	sorting nexin 31	Homo sapiens	85-90
23169696-13	2013	CONCLUSIONS: The asparagine at amino acid position 802 appears to be essential for the activity of the CASR protein and is implicated in the mechanism of CASR signaling.	Asparagine	17-27	calcium sensing receptor	Homo sapiens	103-107
23161488-1	2013	L-Asparaginase (L-Asnase) can suppress the growth of malignant cells by rapid depletion of two essential amino acids, L-glutamine (L-Gln) and L-asparagine (L-Asn).	Asparagine	142-154	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
23161488-1	2013	L-Asparaginase (L-Asnase) can suppress the growth of malignant cells by rapid depletion of two essential amino acids, L-glutamine (L-Gln) and L-asparagine (L-Asn).	Asparagine	142-154	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-24
23161488-1	2013	L-Asparaginase (L-Asnase) can suppress the growth of malignant cells by rapid depletion of two essential amino acids, L-glutamine (L-Gln) and L-asparagine (L-Asn).	Asparagine	16-21	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
22789031-4	2013	The asn2 mutant leaves displayed a depleted asparagine and an accumulation of alanine, GABA, pyruvate and fumarate, indicating an alanine formation from pyruvate through the GABA shunt to consume excess ammonium in the absence of asparagine synthesis.	Asparagine	44-54	asparagine synthetase 2	Arabidopsis thaliana	4-8
23305235-12	2013	GDNF is modified by N-linked glycosylation at one (Asn(49)) out of two consensus sites.	Asparagine	51-54	glial cell derived neurotrophic factor	Homo sapiens	0-4
23283728-2	2013	Proteins that have both these functional groups in abundance are no exception, and presence of amino acids such as asparagine, glutamines, aspartic acids, and glutamic acids aid in formation of such intermediates.	Asparagine	115-125	activation induced cytidine deaminase	Homo sapiens	174-177
22789031-4	2013	The asn2 mutant leaves displayed a depleted asparagine and an accumulation of alanine, GABA, pyruvate and fumarate, indicating an alanine formation from pyruvate through the GABA shunt to consume excess ammonium in the absence of asparagine synthesis.	Asparagine	230-240	asparagine synthetase 2	Arabidopsis thaliana	4-8
22789031-7	2013	Moreover, lack of asparagine in asn2 phloem sap and lowered (15) N flux to sinks, accompanied by the delayed yellowing (senescence) of asn2 leaves, in the absence of asparagine support a specific role of asparagine in phloem loading and nitrogen reallocation.	Asparagine	18-28	asparagine synthetase 2	Arabidopsis thaliana	32-36
22985488-10	2013	Nevertheless, two combined nonfunctioning mutations were detected: a single-nucleotide polymorphism (SNP) of the TSHR gene, in exon 7, at codon 187 (AAT AAC, both encoding asparagine), and a SNP within exon 8 of the Gsalpha gene at codon 185 (ATC ATT, both encoding isoleucine).	Asparagine	172-182	thyroid stimulating hormone receptor	Homo sapiens	113-117
23212906-2	2013	To elucidate the functional significance of N-glycosylation sites of STIM1, we created different mutations of asparagine-131 and asparagine-171.	Asparagine	110-120	stromal interaction molecule 1	Homo sapiens	69-74
23212906-2	2013	To elucidate the functional significance of N-glycosylation sites of STIM1, we created different mutations of asparagine-131 and asparagine-171.	Asparagine	129-139	stromal interaction molecule 1	Homo sapiens	69-74
23169696-13	2013	CONCLUSIONS: The asparagine at amino acid position 802 appears to be essential for the activity of the CASR protein and is implicated in the mechanism of CASR signaling.	Asparagine	17-27	calcium sensing receptor	Homo sapiens	154-158
23237799-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro.	Asparagine	151-154	annexin A2	Bos taurus	42-52
23237799-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro.	Asparagine	151-154	legumain	Bos taurus	92-100
23237799-3	2013	We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro.	Asparagine	151-154	annexin A2	Bos taurus	134-144
23177926-1	2013	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of an oligosaccharide to an asparagine residue in glycoproteins.	Asparagine	115-125	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
23177926-1	2013	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of an oligosaccharide to an asparagine residue in glycoproteins.	Asparagine	115-125	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Asparagine	193-203	Vif	Human immunodeficiency virus 1	31-34
23161549-7	2013	Binding of t-PA to VDAC occurs between a t-PA fibronectin type I finger domain located between amino acids Ile(5) and Asn(37) and a VDAC region including amino acids (20)GYGFG(24).	Asparagine	118-121	plasminogen activator, tissue type	Homo sapiens	11-15
24018687-3	2013	Site-directed mutational analysis of the consensus N-glycosylation sites of the DDRs revealed that mutations of asparagine 213 of DDR2 and asparagine 211 of DDR1, a conserved N-glycosylation site among vertebrate DDRs, inhibited the generation of the high-molecular-mass isoform.	Asparagine	112-122	discoidin domain receptor tyrosine kinase 2	Homo sapiens	130-134
24018687-3	2013	Site-directed mutational analysis of the consensus N-glycosylation sites of the DDRs revealed that mutations of asparagine 213 of DDR2 and asparagine 211 of DDR1, a conserved N-glycosylation site among vertebrate DDRs, inhibited the generation of the high-molecular-mass isoform.	Asparagine	112-122	discoidin domain receptor tyrosine kinase 1	Homo sapiens	157-161
24018687-3	2013	Site-directed mutational analysis of the consensus N-glycosylation sites of the DDRs revealed that mutations of asparagine 213 of DDR2 and asparagine 211 of DDR1, a conserved N-glycosylation site among vertebrate DDRs, inhibited the generation of the high-molecular-mass isoform.	Asparagine	139-149	discoidin domain receptor tyrosine kinase 1	Homo sapiens	157-161
23167757-5	2013	By site-directed mutagenesis and enzymatic deglycosylation, we show here that all three Asn residues within the potential N-linked glycosylation sites of human PDIA2 (N127, N284 and N516) are glycosylated in human cells.	Asparagine	88-91	protein disulfide isomerase family A member 2	Homo sapiens	160-165
24149797-1	2013	The initial glycan transfer in asparagine-linked protein glycosylation is catalysed by the integral membrane enzyme oligosaccharyltransferase (OST).	Asparagine	31-41	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	143-146
24149797-3	2013	We find that PglB can glycosylate not only asparagine but also glutamine, homoserine and the hydroxamate Asp(NHOH), although at much lower rates.	Asparagine	43-53	epiphycan	Homo sapiens	13-17
24149797-5	2013	We find that of the various peptide analogues, only asparagine- or Dab-containing peptides bind tightly to PglB.	Asparagine	52-62	epiphycan	Homo sapiens	107-111
23098902-5	2013	Recombinant N-terminal His-tagged AGT1 purified from Escherichia coli was characterized with Ser, alanine (Ala) and Asn as amino acid donors and glyoxylate, pyruvate and hydroxypyruvate as organic acid acceptors.	Asparagine	116-119	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	34-38
23098902-6	2013	The V(max) of AGT1 with Asn was higher than with Ser or Ala by ca.	Asparagine	24-27	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	14-18
23098902-9	2013	In the roots of 10-day-old seedlings treated for 2h with 20mM Asn, the AGT1 transcript levels were raised by 2-fold.	Asparagine	62-65	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	71-75
23098902-12	2013	These results suggest that AGT1 is involved in Asn metabolism in Arabidopsis.	Asparagine	47-50	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	27-31
23527139-9	2013	Based on these interactions it was found that antibody successfully blocks the glycosylation site ASN 67 and other conserved residues present at DC-SIGN-Den-E complex interface.	Asparagine	98-101	CD209 molecule	Homo sapiens	145-152
23408971-13	2013	This localization of dFMRP in SG requires the KH and RGG motifs which are known to mediate RNA binding, as well as the C-terminal glutamine/asparagine rich domain.	Asparagine	140-150	Fmr1	Drosophila melanogaster	21-26
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Asparagine	193-203	Vif	Human immunodeficiency virus 1	144-147
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Asparagine	193-203	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	173-176
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Asparagine	193-203	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	223-226
23774320-4	2013	The transactivation domains (TADs) of Nrf1, including its Asn/Ser/Thr-rich (NST) glycodomain, are transiently translocated into the ER lumen, where it is glycosylated in the presence of glucose to become a 120-kDa isoform.	Asparagine	58-61	nuclear respiratory factor 1	Homo sapiens	38-42
23335989-4	2013	OASIS protein, which is glycosylated on Asn-513, was detected in the U373 and U87 glioma lines at low levels in control cells and protein expression was induced by ER stress.	Asparagine	40-43	cAMP responsive element binding protein 3 like 1	Homo sapiens	0-5
23382816-2	2013	Here, we establish a functional link between epigenetic regulation by Polycomb group (PcG) proteins and transcriptional regulation by C/ebp that orchestrates the correct expression of Bombyx mori asparagine synthetase (BmASNS), a gene involved in the biosynthesis of asparagine.	Asparagine	196-206	polycomb	Bombyx mori	70-78
23382816-2	2013	Here, we establish a functional link between epigenetic regulation by Polycomb group (PcG) proteins and transcriptional regulation by C/ebp that orchestrates the correct expression of Bombyx mori asparagine synthetase (BmASNS), a gene involved in the biosynthesis of asparagine.	Asparagine	196-206	chorion specific C/EBP	Bombyx mori	134-139
23126476-6	2012	To address this issue, we applied a stable-isotope (18)O-labeling method combined with nano-LC-MS/MS to examine the susceptibility of two Asn-Gly sites in beta2-microglobulin (beta2m) to the reaction.	Asparagine	138-141	beta-2-microglobulin	Homo sapiens	155-174
23738234-12	2013	Cold-stored E. coli-derived L-asparaginase depletes asparagine and retains enzymatic activity.	Asparagine	52-62	asparaginase and isoaspartyl peptidase 1	Canis lupus familiaris	28-42
23192044-4	2012	Recombinant human e5NT comprising four asparagine-to-aspartate surface mutations targeting potential glycosylation sites was refolded from bacterial inclusion bodies.	Asparagine	39-49	5'-nucleotidase ecto	Homo sapiens	18-22
23135810-8	2012	Whereas, an analogous peptide, BDNF(1-12)D3N, in which the aspartate residue was substituted by an asparagine, was synthesized to provide evidence on the possible role of carboxylate group in Cu(2+) coordination.	Asparagine	99-109	brain derived neurotrophic factor	Homo sapiens	31-35
23112166-6	2012	Analysis of the changes in protein levels and structural modeling indicate that P-body formation in cells with the mutation in CCT3 is linked to the specific interaction of this subunit with Gln/Asn-rich segments that are enriched in many P-body proteins.	Asparagine	195-198	chaperonin-containing T-complex subunit CCT3	Saccharomyces cerevisiae S288C	127-131
23041570-7	2012	Further, mass spectrometric characterization of plasma-derived C5a and C5a(desArg) provided important insight into the posttranslational modification pattern of these anaphylatoxins, which includes glycosylation at Asn(64) and partial cysteinylation at Cys(27).	Asparagine	215-218	complement C5a receptor 1	Homo sapiens	63-66
22978355-5	2012	Direct DNA sequencing of the lysozyme gene revealed a single base nucleotide transversion from T to A at the first position of codon 54, resulting in replacement of Tyr by Asn in the mature lysozyme protein (pTyr54Asn).	Asparagine	172-175	lysozyme	Homo sapiens	29-37
22978355-5	2012	Direct DNA sequencing of the lysozyme gene revealed a single base nucleotide transversion from T to A at the first position of codon 54, resulting in replacement of Tyr by Asn in the mature lysozyme protein (pTyr54Asn).	Asparagine	172-175	lysozyme	Homo sapiens	190-198
23020770-7	2012	C31 binds directly to the PP2A catalytic subunit, through the asparagine, proline, threonine, tyrosine (NPTY) motif, which is essential for C31-induced tau hyperphosphorylation.	Asparagine	62-72	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	26-30
23161171-7	2012	The C-terminal side transcriptional activation domain of AtMYB44 contains an asparagine-rich fragment, NINNTTSSRHNHNN (aa 215-228), which, among the members of subgroup 22, is unique to AtMYB44.	Asparagine	77-87	myb domain protein r1	Arabidopsis thaliana	57-64
23161171-7	2012	The C-terminal side transcriptional activation domain of AtMYB44 contains an asparagine-rich fragment, NINNTTSSRHNHNN (aa 215-228), which, among the members of subgroup 22, is unique to AtMYB44.	Asparagine	77-87	myb domain protein r1	Arabidopsis thaliana	186-193
22995912-8	2012	Here we show that mutations of two distant Kir2.1 cytosolic residues, Leu-222 and Asn-251, form a two-way molecular switch that controls channel modulation by cholesterol and affects critical hydrogen bonding.	Asparagine	82-85	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	43-49
22891768-1	2012	The human asparaginase-like protein 1 (hASRGL1) catalyzes the hydrolysis of l-asparagine and isoaspartyl-dipeptides.	Asparagine	76-88	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-37
22891768-1	2012	The human asparaginase-like protein 1 (hASRGL1) catalyzes the hydrolysis of l-asparagine and isoaspartyl-dipeptides.	Asparagine	76-88	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-46
23166962-20	2004	Cy5.5-8-Amino-octanoic acid-Ser-Cys-Pro-Pro-Trp-Gln-Glu-Trp-His-Asn-Phe-Met-Pro-Phe-NH2 (Cy5.5-Aoc-EGBP) was evaluated for use with in vivo near-infrared (NIR) fluorescence imaging in mice with EGFR-positive tumors.	Asparagine	64-67	epidermal growth factor receptor	Mus musculus	194-198
23038983-6	2012	We found decreased site-specific N-glycosylation occupancy in the alg3 knockout strain preferentially at Asn-Xaa-Ser sequences located in secondary structural elements, features previously associated with poor glycosylation efficiency.	Asparagine	105-108	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	66-70
23295288-9	2012	Molecular investigation identified a novel mutation that consists of a deletion of codon 372 (AAC; asparagine) in exon 1 of DAX1.	Asparagine	99-109	glycine-N-acyltransferase	Homo sapiens	94-97
22988234-5	2012	In the first step, PKCdelta translocates acutely to mitochondria by a mechanism that requires its C1A and C1B domains and a Leu-Asn sequence in its turn motif.	Asparagine	128-131	protein kinase C delta	Homo sapiens	19-27
23295288-9	2012	Molecular investigation identified a novel mutation that consists of a deletion of codon 372 (AAC; asparagine) in exon 1 of DAX1.	Asparagine	99-109	nuclear receptor subfamily 0 group B member 1	Homo sapiens	124-128
22898811-10	2012	We also determined by using site-directed mutagenesis that asparagine residues 40, 88, and 96 of rat ZIP8 are glycosylated and that N-glycosylation is not required for iron or zinc transport.	Asparagine	59-69	solute carrier family 39 member 8	Rattus norvegicus	101-105
22766194-0	2012	The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity.	Asparagine	38-41	membrane metalloendopeptidase	Homo sapiens	10-14
22766194-0	2012	The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity.	Asparagine	38-41	membrane metalloendopeptidase	Homo sapiens	86-107
22766194-8	2012	Surface expression of N-glycan at Asn(628)-deleted CD10 by HEK293 cells was greatly decreased as well as it lost entire NEP activities.	Asparagine	34-37	membrane metalloendopeptidase	Homo sapiens	51-55
22766194-8	2012	Surface expression of N-glycan at Asn(628)-deleted CD10 by HEK293 cells was greatly decreased as well as it lost entire NEP activities.	Asparagine	34-37	membrane metalloendopeptidase	Homo sapiens	120-123
22766194-9	2012	CONCLUSIONS: N-glycosylation at Asn(628) is essential not only for NEP activities, but also for surface expression.	Asparagine	32-35	membrane metalloendopeptidase	Homo sapiens	67-70
22899366-6	2012	An Asn residue in the binding pocket of PDE4 has enhanced the specificity of the binding to cAMP sideway as observed in our computer simulation.	Asparagine	3-6	phosphodiesterase 4A	Homo sapiens	40-44
23044006-15	2012	A9(Ser Asn) amino acid single mutation human insulin originated from the mistranslation of A9 serine, such that asparagine was translated instead of serine.	Asparagine	7-10	insulin	Homo sapiens	45-52
23044006-15	2012	A9(Ser Asn) amino acid single mutation human insulin originated from the mistranslation of A9 serine, such that asparagine was translated instead of serine.	Asparagine	112-122	insulin	Homo sapiens	45-52
22820273-1	2012	The human CHRNA5 D398N polymorphism (rs16969968) causes an aspartic acid to asparagine change in the nicotinic acetylcholine receptor (nAChR) alpha5 subunit gene.	Asparagine	76-86	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	10-16
23001782-5	2012	It was found that serum-derived hSHBG is N-glycosylated at Asn(351)  and Asn(367)  with average molar occupancies of 85.1 and 95.3%, respectively.	Asparagine	59-62	sex hormone binding globulin	Homo sapiens	32-37
23001782-5	2012	It was found that serum-derived hSHBG is N-glycosylated at Asn(351)  and Asn(367)  with average molar occupancies of 85.1 and 95.3%, respectively.	Asparagine	73-76	sex hormone binding globulin	Homo sapiens	32-37
23001782-10	2012	Interestingly, the size and charge heterogeneity were shown to originate predominantly from differential Asn(351)  glycan occupancies and N-glycan sialylation that may modulate the hSHBG activity.	Asparagine	105-108	sex hormone binding globulin	Homo sapiens	181-186
22967898-4	2012	We demonstrated that cathepsin V is N-glycosylated at both Asn(221) and Asn(292) using mass spectrometry and site-directed mutagenesis.	Asparagine	59-62	cathepsin V	Homo sapiens	21-32
22967898-4	2012	We demonstrated that cathepsin V is N-glycosylated at both Asn(221) and Asn(292) using mass spectrometry and site-directed mutagenesis.	Asparagine	72-75	cathepsin V	Homo sapiens	21-32
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Asparagine	104-107	membrane metalloendopeptidase	Homo sapiens	9-19
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Asparagine	104-107	islet amyloid polypeptide	Homo sapiens	30-34
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Asparagine	138-141	membrane metalloendopeptidase	Homo sapiens	9-19
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Asparagine	138-141	islet amyloid polypeptide	Homo sapiens	30-34
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Asparagine	138-141	islet amyloid polypeptide	Homo sapiens	62-66
22733492-10	2012	Prediction of the 3-D structure shows mutations 36Asp   Asn, 38Asn   Asp and 43 Ile   Thr were on the concave surface of LBP protein at barrel-N, 67Ala   Thr was in the apolar pocket at barrel-N. Motif analysis shows 36Asp   Asn causes loss of a CK2 phosphorylation site, 67 Ala   Thr forms a new PKC phosphorylation site.	Asparagine	56-59	lipopolysaccharide binding protein	Bos taurus	121-124
22951255-1	2012	An adenylated sulfoximine transition-state analogue 1, which inhibits human asparagine synthetase (hASNS) with nanomolar potency, has been reported to suppress the proliferation of an l-asparagine amidohydrolase (ASNase)-resistant MOLT-4 leukemia cell line (MOLT-4R) when l-asparagine is depleted in the medium.	Asparagine	184-196	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	99-104
22674847-2	2012	Here, we present results of pressure-induced denaturation studies of an amyloidogenic protein-the wild-type human cystatin C (hCC) and its single-point mutants, in which Val57 residue from the hinge region was substituted by Asn, Asp or Pro, respectively.	Asparagine	225-228	cystatin C	Homo sapiens	114-124
22733492-10	2012	Prediction of the 3-D structure shows mutations 36Asp   Asn, 38Asn   Asp and 43 Ile   Thr were on the concave surface of LBP protein at barrel-N, 67Ala   Thr was in the apolar pocket at barrel-N. Motif analysis shows 36Asp   Asn causes loss of a CK2 phosphorylation site, 67 Ala   Thr forms a new PKC phosphorylation site.	Asparagine	63-66	lipopolysaccharide binding protein	Bos taurus	121-124
22726556-1	2012	Simultaneous silencing of asparagine synthetase (Ast)-1 and -2 limits asparagine (ASN) formation and, consequently, reduces the acrylamide-forming potential of tubers.	Asparagine	82-85	asparagine synthetase [glutamine-hydrolyzing]	Solanum tuberosum	26-62
23045425-9	2012	The present study and the other two cases reported in the literature stress the important role of the asn 540 site in the tyrosine kinase I domain in the pathogenesis of HCH and underline the importance that, in patients with HCH who do not have the common N540K mutation, sequence analysis of the tyrosine kinase I domain of FGFR3 should be performed to exclude other changes in that region.	Asparagine	102-105	fibroblast growth factor receptor 3	Homo sapiens	326-331
22833678-12	2012	When the Asn-736 residue of Vps34p was mutated and when the C-terminal 11 amino acids were deleted, mutant proteins failed to co-localize with actin patches, and FBPase in the extracellular fraction did not decrease as rapidly.	Asparagine	9-12	phosphatidylinositol 3-kinase VPS34	Saccharomyces cerevisiae S288C	28-34
23240411-6	2012	By analyzing the assignations of the SERS bands, it was found that the content of asparagine, tyrosine and phenylalanine in the hemoglobin are significantly lower than healthy people.	Asparagine	82-92	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	37-41
22875854-5	2012	1) The only P1 residues recognized by PCSK9 are Gln &gt; Met &gt; Ala &gt; Ser &gt; Thr   Asn, revealing an unsuspected specificity.	Asparagine	90-93	proprotein convertase subtilisin/kexin type 9	Homo sapiens	38-43
23113336-6	2012	A substitution of asparagine for serine (S18N) in the transmembrane domain of the prolactin receptor (PRLR) was also examined, but it did not significantly affect the milk production parameters.	Asparagine	18-28	prolactin receptor	Homo sapiens	82-100
22864933-8	2012	The meta-analysis also identified 1 missense variant (rs11722476; serine to asparagine) within switch/sucrose nonfermentable-related, matrix-associated, actin-dependent regulator of chromatin (SMARCAD1), a novel gene for association with capecitabine/5-FU susceptibility.	Asparagine	76-86	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	Homo sapiens	193-201
22745130-5	2012	Unexpectedly, the structure of pDCR refined to 1.84 A resolution reveals the absence of the tyrosine-serine pair seen in the active site of mDCR, which together with a lysine and an asparagine have been deemed a hallmark of the SDR family of enzymes.	Asparagine	182-192	2,4-dienoyl-CoA reductase 2	Homo sapiens	31-35
22356135-1	2012	A recent study suggested that mesenchymal cells in bone marrow (BM) may counteract l-asparaginase (L-Asp)-containing acute lymphoblastic leukemia (ALL) therapy by secreting asparagine.	Asparagine	173-183	asparaginase and isoaspartyl peptidase 1	Homo sapiens	83-97
22356135-1	2012	A recent study suggested that mesenchymal cells in bone marrow (BM) may counteract l-asparaginase (L-Asp)-containing acute lymphoblastic leukemia (ALL) therapy by secreting asparagine.	Asparagine	173-183	asparaginase and isoaspartyl peptidase 1	Homo sapiens	99-104
22356135-6	2012	However, it may be overcome by continuous action of L-Asp, which is mirrored by increased aspartic acid levels but unchanged low asparagine levels in BM, suggesting a higher BM turnover of asparagine generated by L-Asp during induction therapy.	Asparagine	129-139	asparaginase and isoaspartyl peptidase 1	Homo sapiens	52-57
22356135-6	2012	However, it may be overcome by continuous action of L-Asp, which is mirrored by increased aspartic acid levels but unchanged low asparagine levels in BM, suggesting a higher BM turnover of asparagine generated by L-Asp during induction therapy.	Asparagine	189-199	asparaginase and isoaspartyl peptidase 1	Homo sapiens	52-57
22356135-6	2012	However, it may be overcome by continuous action of L-Asp, which is mirrored by increased aspartic acid levels but unchanged low asparagine levels in BM, suggesting a higher BM turnover of asparagine generated by L-Asp during induction therapy.	Asparagine	189-199	asparaginase and isoaspartyl peptidase 1	Homo sapiens	213-218
21968931-11	2012	In this risk region, there is a common (among European-origin people) mis-sense single-nucleotide polymorphism in the CHRNA5 gene (D398N), which changes a conserved amino acid from aspartic acid to asparagine.	Asparagine	198-208	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	118-124
22688517-7	2012	With this approach, one potential glycosylation site of recombinant human LOX-1 on Asn(139) is readily identified and found to carry heterogeneous complex type N-glycans.	Asparagine	83-86	oxidized low density lipoprotein receptor 1	Homo sapiens	74-79
22750213-5	2012	By using site-directed mutagenesis, the asparagine-43 was identified to be the N-linked glycosylation site of PRiMA.	Asparagine	40-50	proline rich membrane anchor 1	Mus musculus	110-115
22542578-2	2012	Recent studies question the traditional view that the level of asparagine synthetase (ASNS), an enzyme producing the intracellular asparagine, correlates with the response to L-asp treatment.	Asparagine	63-73	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	86-90
22542578-2	2012	Recent studies question the traditional view that the level of asparagine synthetase (ASNS), an enzyme producing the intracellular asparagine, correlates with the response to L-asp treatment.	Asparagine	63-73	asparaginase and isoaspartyl peptidase 1	Homo sapiens	175-180
22513289-2	2012	We also investigated, in tumor-bearing mice, the efficacy of L-asparaginase entrapped in red blood cells (RBCs), a safe formulation, to induce asparagine depletion.	Asparagine	143-153	asparaginase like 1	Mus musculus	61-75
22687491-3	2012	Although the two enzymes have similar active sites, FIH hydroxylates Asn(803) of HIF-1alpha while PHD2 hydroxylates Pro(402) and/or Pro(564) of HIF-1alpha.	Asparagine	69-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
22687491-3	2012	Although the two enzymes have similar active sites, FIH hydroxylates Asn(803) of HIF-1alpha while PHD2 hydroxylates Pro(402) and/or Pro(564) of HIF-1alpha.	Asparagine	69-72	egl-9 family hypoxia inducible factor 1	Homo sapiens	98-102
22513289-7	2012	The highest in vitro cytotoxicity to L-asparaginase or to reduced asparagine medium was observed with SW1990 line when ASNS expression was the lowest.	Asparagine	66-76	asparagine synthetase	Mus musculus	119-123
22513289-9	2012	CONCLUSIONS: Plasma asparagine depletion by RBC-entrapped L-asparaginase in selected patients having no low or no ASNS may be a promising therapeutic approach for pancreatic cancer.	Asparagine	20-30	asparaginase and isoaspartyl peptidase 1	Homo sapiens	58-72
22513289-9	2012	CONCLUSIONS: Plasma asparagine depletion by RBC-entrapped L-asparaginase in selected patients having no low or no ASNS may be a promising therapeutic approach for pancreatic cancer.	Asparagine	20-30	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	114-118
22674578-2	2012	hNit2/omega-amidase plays a crucial metabolic role by catalyzing the hydrolysis of alpha-ketoglutaramate (the alpha-keto analog of glutamine) and alpha-ketosuccinamate (the alpha-keto analog of asparagine), yielding alpha-ketoglutarate and oxaloacetate, respectively.	Asparagine	194-204	nitrilase family member 2	Homo sapiens	0-5
22718532-4	2012	Using a MS approach, we identified two truncated TDP-43 peptides, terminating C-terminal to asparagines 291 (N291) and 306 (N306).	Asparagine	92-103	TAR DNA binding protein	Homo sapiens	49-55
22718532-5	2012	The only documented mammalian enzyme capable of cleaving C-terminal to asparagine is asparaginyl endopeptidase (AEP).	Asparagine	71-81	legumain	Homo sapiens	85-110
22718532-5	2012	The only documented mammalian enzyme capable of cleaving C-terminal to asparagine is asparaginyl endopeptidase (AEP).	Asparagine	71-81	legumain	Homo sapiens	112-115
22621930-4	2012	An asparagine (Asn-391) in the UGT signature sequence of UGT3A1 is necessary for utilization of UDP-GlcNAc.	Asparagine	3-13	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	31-34
22621930-4	2012	An asparagine (Asn-391) in the UGT signature sequence of UGT3A1 is necessary for utilization of UDP-GlcNAc.	Asparagine	3-13	UDP glycosyltransferase family 3 member A1	Homo sapiens	57-63
22621930-4	2012	An asparagine (Asn-391) in the UGT signature sequence of UGT3A1 is necessary for utilization of UDP-GlcNAc.	Asparagine	15-18	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	31-34
22621930-4	2012	An asparagine (Asn-391) in the UGT signature sequence of UGT3A1 is necessary for utilization of UDP-GlcNAc.	Asparagine	15-18	UDP glycosyltransferase family 3 member A1	Homo sapiens	57-63
22621930-7	2012	An analysis of homology models docked with UDP-sugar donors indicates that Asn-391 in UGT3A1 is able to accommodate the N-acetyl group on C2 of UDP-GlcNAc so that the anomeric carbon atom (C1) is optimally situated for catalysis involving His-35.	Asparagine	75-78	UDP glycosyltransferase family 3 member A1	Homo sapiens	86-92
22651575-7	2012	An asparagine at this position is conserved in four of the deviant Walker A motif subfamilies (MinD, chromosomal ParAs, Get3 and FleN) and we find that N45 in MinD is essential for MinE-stimulated ATPase activity and suggest that it is a key residue affected by MinE binding.	Asparagine	3-13	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	120-124
24750858-4	2012	Several structural fragments such as AraHex2-HexA-HexNAc, Hex4HexNAc2, AraHex4HexNAc, Hex10HexNAc and Hex4HexNAc-Asn were identified from MALDI-TOF spectrum; using 1D and 2D NMR spectra, the linkage site of amino acids and polysaccharides was determined as N-linked (Hex)n-GlcNAc-Asn.	Asparagine	280-283	hematopoietically expressed homeobox	Homo sapiens	40-43
22713602-7	2012	The glutamine/asparagine (Q/N)-rich protein MUT-16 is specifically required for the formation of a protein complex containing the mutator proteins, and in its absence, Mutator foci fail to form at the nuclear periphery.	Asparagine	14-24	MUTator	Caenorhabditis elegans	44-50
22651575-7	2012	An asparagine at this position is conserved in four of the deviant Walker A motif subfamilies (MinD, chromosomal ParAs, Get3 and FleN) and we find that N45 in MinD is essential for MinE-stimulated ATPase activity and suggest that it is a key residue affected by MinE binding.	Asparagine	3-13	dynein axonemal heavy chain 8	Homo sapiens	197-203
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Asparagine	53-63	gastric inhibitory polypeptide	Rattus norvegicus	122-125
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Asparagine	53-63	glucagon	Rattus norvegicus	127-132
22535958-5	2012	Mutation of the highly conserved tryptophan-asparagine sequence within the TM domain of Ostbeta to alanines did not prevent cell surface trafficking, but abolished transport activity.	Asparagine	44-54	solute carrier family 51 subunit beta	Homo sapiens	88-95
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Asparagine	65-68	gastric inhibitory polypeptide	Rattus norvegicus	122-125
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Asparagine	65-68	glucagon	Rattus norvegicus	127-132
22734907-2	2012	Here, we report on a heterozygous mutation in EGR2 (c.1160C>A), which results in threonine at position 387 being changed to asparagine, in a family with a mild demyelinating form of adult-onset CMT.	Asparagine	124-134	early growth response 2	Homo sapiens	46-50
21800258-8	2012	This enhanced inhibition was associated with increased accumulation of asparagine in the root of the double aspga1-1/-b1-1 mutant.	Asparagine	71-81	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	108-114
22594522-6	2012	RESULTS: Plasma asparagine levels were significantly lower after the first injection of ASNase (p &lt; 0.01) and had almost recovered 2 weeks after the last ASNase injection.	Asparagine	16-26	asparaginase and isoaspartyl peptidase 1	Homo sapiens	88-94
22594522-6	2012	RESULTS: Plasma asparagine levels were significantly lower after the first injection of ASNase (p &lt; 0.01) and had almost recovered 2 weeks after the last ASNase injection.	Asparagine	16-26	asparaginase and isoaspartyl peptidase 1	Homo sapiens	157-163
22446789-2	2012	The structure of the title compound which crystallizes in the non-centrosymmetric monoclinic space group P2(1) consists of a molecule of L-asparagine and a molecule of free l-tartaric acid both of which are interlinked by three varieties of H-bonding interactions namely O-H   O, N-H   O and C-H   O.	Asparagine	137-149	H3 histone pseudogene 16	Homo sapiens	105-110
21780104-0	2012	alpha1-3/4 fucosylation at Asn 241 of beta-haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.	Asparagine	27-30	adrenoceptor alpha 1D	Homo sapiens	0-8
22493292-5	2012	In this study, we characterize mutants of this residue from the neuronal transporter EAAC1, Asn-451.	Asparagine	92-95	solute carrier family 1 member 1	Homo sapiens	85-90
21780104-9	2012	In particular, fucosylation at Asn 241 of beta-Hp in sera of colon cancer patients was clearly higher than in the other groups, and the ratio of fucosylated glycopeptides containing Asn 241 decreased greatly after treatment with alpha1-3/4 fucosidase.	Asparagine	31-34	adrenoceptor alpha 1D	Homo sapiens	229-237
21780104-9	2012	In particular, fucosylation at Asn 241 of beta-Hp in sera of colon cancer patients was clearly higher than in the other groups, and the ratio of fucosylated glycopeptides containing Asn 241 decreased greatly after treatment with alpha1-3/4 fucosidase.	Asparagine	182-185	adrenoceptor alpha 1D	Homo sapiens	229-237
21780104-10	2012	In conclusion, the level of alpha1-3/4 fucosyl epitope at Asn 241 of beta-Hp is potentially useful as a novel marker for colon cancer.	Asparagine	58-61	adrenoceptor alpha 1D	Homo sapiens	28-36
22498501-3	2012	Asparagine has been subjected to matrix-isolation FT-IR spectroscopy supported with DFT and MP2 calculations.	Asparagine	0-10	tryptase pseudogene 1	Homo sapiens	92-95
22411732-6	2012	Analogous Glu-Asn pair in tricon interacting factor F3 (F3) and Gln-Asn pair in human leukotriene A(4) hydrolase (LTA(4) H) are also conserved in respective homologs.	Asparagine	14-17	leukotriene A4 hydrolase	Homo sapiens	86-112
21950590-9	2012	These data underscore the importance of asparagine at amino acid position 771 of human AR in normal ligand binding and normal receptor function, and a mutation at this position results in androgen insensitivity in affected subjects.	Asparagine	40-50	androgen receptor	Homo sapiens	87-89
22005787-8	2012	IGFBP7, in an insulin/IGF-dependent manner, enhanced asparagine synthetase expression and asparagine secretion by BMSCs, thus providing a stromal-dependent mechanism by which IGFBP7 protects ALL cells against asparaginase in this coculture system.	Asparagine	53-63	insulin like growth factor binding protein 7	Homo sapiens	0-6
22005787-8	2012	IGFBP7, in an insulin/IGF-dependent manner, enhanced asparagine synthetase expression and asparagine secretion by BMSCs, thus providing a stromal-dependent mechanism by which IGFBP7 protects ALL cells against asparaginase in this coculture system.	Asparagine	53-63	insulin like growth factor binding protein 7	Homo sapiens	175-181
22246941-2	2012	Hedgehog APRIL contains two cysteine residues (Cys(196) and Cys(211)), a furin protease cleavage site and a conserved putative N-glycosylation site (Asn(124)).	Asparagine	149-152	tumor necrosis factor ligand superfamily member 13-like	Erinaceus europaeus	9-14
22589192-12	2012	Other modifications observed, in PRDX6 from mouse liver tissues included, among others, mono- and dioxidation at Trp and Met, acetylation at Lys, and deamidation at Asn and Gln.	Asparagine	165-168	peroxiredoxin 6	Mus musculus	33-38
23248692-3	2012	Sequencing analysis of voltage-gated sodium channel a1-subunit gene, SCN1A, confirmed a homozygous A to G change at nucleotide 5197 (c.5197A &gt; G) in exon 26 resulting in amino acid substitution of asparagines to aspartate at codon 1733 of sodium channel.	Asparagine	200-211	sodium voltage-gated channel alpha subunit 1	Homo sapiens	69-74
22127737-3	2012	However, ASPGB1 had a 45-fold higher specific activity with Asn as substrate than ASPGA1.	Asparagine	60-63	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	9-15
22127737-7	2012	Exchanging the variable loop in ASPGA1 with that from ASPGB1 increased the affinity for Asn, with a 320-fold reduction in K                         (m) value.	Asparagine	88-91	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	32-38
22127737-7	2012	Exchanging the variable loop in ASPGA1 with that from ASPGB1 increased the affinity for Asn, with a 320-fold reduction in K                         (m) value.	Asparagine	88-91	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	54-60
22127737-8	2012	Homology modeling identified a residue specific to ASPGB1, Phe(162), preceding the variable loop, whose side chain is located in proximity to the beta-carboxylate group of the product aspartate, and to Gly(246), a residue participating in an oxyanion hole which stabilizes a negative charge forming on the side chain oxygen of asparagine during catalysis.	Asparagine	327-337	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	51-57
22127737-9	2012	Replacement with the corresponding leucine from ASPGA1 specifically lowered the V                         (max) value with Asn as substrate by 8.4-fold.	Asparagine	123-126	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	48-54
22411732-6	2012	Analogous Glu-Asn pair in tricon interacting factor F3 (F3) and Gln-Asn pair in human leukotriene A(4) hydrolase (LTA(4) H) are also conserved in respective homologs.	Asparagine	14-17	leukotriene A4 hydrolase	Homo sapiens	114-122
22303015-5	2012	Second, beta3(G32R) subunits were more likely than beta3 subunits to be N-glycosylated at Asn-33, but increases in glycosylation were not responsible for changes in subunit surface expression.	Asparagine	90-93	basic helix-loop-helix family member e22	Homo sapiens	8-13
22367195-4	2012	Mutagenesis analysis showed that four critical residues (Arg-82, Cys-83, Asn-86, and Ser-87) located in the IRF family conserved DNA binding domain-helix alpha3 were involved in DNA binding and POLH transactivation by IRF1.	Asparagine	73-76	interferon regulatory factor 1	Homo sapiens	218-222
22399287-10	2012	Mutagenesis screening showed that CNNM2 is glycosylated at residue Asn-112, stabilizing CNNM2 on the plasma membrane.	Asparagine	67-70	cyclin and CBS domain divalent metal cation transport mediator 2	Homo sapiens	34-39
22399287-10	2012	Mutagenesis screening showed that CNNM2 is glycosylated at residue Asn-112, stabilizing CNNM2 on the plasma membrane.	Asparagine	67-70	cyclin and CBS domain divalent metal cation transport mediator 2	Homo sapiens	88-93
22070093-3	2012	TaGCN2 overexpression in transgenic wheat resulted in significant decreases in total free amino acid concentration in the grain, with free asparagine concentration in particular being much lower than in controls.	Asparagine	139-149	eIF-2-alpha kinase GCN2	Triticum aestivum	0-6
22517861-3	2012	We identified Mod5, a yeast transfer RNA isopentenyltransferase lacking glutamine/asparagine-rich domains, as a yeast prion protein and found that its prion conversion in yeast regulated the sterol biosynthetic pathway for acquired cellular resistance against antifungal agents.	Asparagine	82-92	tRNA dimethylallyltransferase	Saccharomyces cerevisiae S288C	14-18
22070093-8	2012	It shows that manipulation of TaGCN2 gene expression could be used to reduce free asparagine accumulation in wheat grain and the risk of acrylamide formation in wheat products.	Asparagine	82-92	eIF-2-alpha kinase GCN2	Triticum aestivum	30-36
22270367-1	2012	Factor Inhibiting HIF (FIH) catalyzes the beta-hydroxylation of asparagine residues in HIF-alpha transcription factors as well as ankyrin repeat domain (ARD) proteins such as Notch and Gankyrin.	Asparagine	64-74	proteasome 26S subunit, non-ATPase 10	Homo sapiens	185-193
22405770-2	2012	Although Hsp30p contains a potential N-glycosylation consensus sequence (Asn(2)-Asp(3)-Thr(4)), whether it is actually N-glycosylated has not been verified.	Asparagine	73-76	Hsp30p	Saccharomyces cerevisiae S288C	9-15
22405770-3	2012	Here we demonstrate that N-glycosylation is induced at Asn(2) of Hsp30p by severe heat shock, ethanol stress, and acetic acid stress.	Asparagine	55-58	Hsp30p	Saccharomyces cerevisiae S288C	65-70
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Asparagine	86-89	angiotensin converting enzyme 2	Homo sapiens	44-49
22315216-10	2012	Non-conserved residues in the binding pocket that strongly contribute to D1/D2 receptor agonist selectivity were also identified; those were Ser/Cys3 36, Tyr/Phe5 38, Ser/Tyr5 41, and Asn/His6 55 in the transmembrane (TM) helix region, together with Ser/Ile and Leu/Asn in the second extracellular loop (EC2).	Asparagine	184-187	leiomodin 1	Homo sapiens	73-78
22500055-0	2012	Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics.	Asparagine	43-53	dynein light chain LC8-type 1	Homo sapiens	71-74
22235134-0	2012	Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.	Asparagine	94-97	TAR DNA binding protein	Homo sapiens	18-44
22235134-0	2012	Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.	Asparagine	94-97	TAR DNA binding protein	Homo sapiens	46-52
22235134-3	2012	In previous works, we have shown that the C-terminal Gln/Asn-rich region (residues 321-366) of TDP-43 is involved in the interaction of this protein with other members of the heterogeneous nuclear ribonucleoprotein protein family.	Asparagine	57-60	TAR DNA binding protein	Homo sapiens	95-101
22315216-10	2012	Non-conserved residues in the binding pocket that strongly contribute to D1/D2 receptor agonist selectivity were also identified; those were Ser/Cys3 36, Tyr/Phe5 38, Ser/Tyr5 41, and Asn/His6 55 in the transmembrane (TM) helix region, together with Ser/Ile and Leu/Asn in the second extracellular loop (EC2).	Asparagine	266-269	leiomodin 1	Homo sapiens	73-78
22105074-4	2012	Here, using chimeric and point-mutated GLP1R/GIPR, we determined that evolutionarily conserved amino acid residues such as Ile(196) at transmembrane helix 2, Leu(232) and Met(233) at extracellular loop 1, and Asn(302) at extracellular loop 2 of GLP1R are responsible for interaction with ligand and receptor activation.	Asparagine	209-212	gastric inhibitory polypeptide receptor	Homo sapiens	45-49
22235134-5	2012	Our experiments show that in cell lines and primary rat neuronal cultures, the introduction of tandem repeats carrying the 331-369-residue Gln/Asn region from TDP-43 can trigger the formation of phosphorylated and ubiquitinated aggregates that recapitulate many but not all the characteristics observed in patients.	Asparagine	143-146	TAR DNA binding protein	Rattus norvegicus	159-165
21657995-7	2012	It seems that the Asn/Ser variant of the FSH receptor functions more efficiently, while the Ser/Ser and Asn/Asn variants have a tendency to resist to FSH stimulation.	Asparagine	18-21	follicle stimulating hormone receptor	Homo sapiens	41-53
22245216-7	2012	Knockdown of ASNS by small-interfering RNAs in asparagine-deprived media led to growth inhibition in both androgen-responsive (ie, LNCaP) and castration-resistant (ie, C4-2B) prostate cancer cell lines and in cells isolated from a CRPC xenograft (ie, MDA PCa 180-30).	Asparagine	47-57	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	13-17
22245216-8	2012	Together, our results suggest that ASNS is up-regulated in cases of CRPC and that depletion of asparagine using ASNS inhibitors will be a novel strategy for targeting CRPC cells.	Asparagine	95-105	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	112-116
22009587-0	2012	Characterization of recombinant human IL-15 deamidation and its practical elimination through substitution of asparagine 77.	Asparagine	110-120	interleukin 15	Homo sapiens	38-43
22138257-4	2012	The glycosylation of purified, mature PR3 showed some heterogeneity with carbohydrates at Asn 102 and 147 carrying unusual small moieties indicating heavy processing.	Asparagine	90-93	proteinase 3	Homo sapiens	38-41
22147710-6	2012	In addition, mutation of Cys-296, Trp-297, Asn-300, Asn-302, and Leu-307 significantly increased GLP-1(7-36)-NH(2)-mediated signaling bias toward pERK1/2.	Asparagine	43-46	glucagon like peptide 1 receptor	Homo sapiens	97-102
22147710-6	2012	In addition, mutation of Cys-296, Trp-297, Asn-300, Asn-302, and Leu-307 significantly increased GLP-1(7-36)-NH(2)-mediated signaling bias toward pERK1/2.	Asparagine	52-55	glucagon like peptide 1 receptor	Homo sapiens	97-102
22157018-1	2012	In a glucose-salt solution (Earle"s balanced salt solution), asparagine (Asn) stimulates ornithine decarboxylase (ODC) activity in a dose-dependent manner, and the addition of epidermal growth factor (EGF) potentiates the effect of Asn.	Asparagine	61-71	ornithine decarboxylase 1	Homo sapiens	89-112
22157018-1	2012	In a glucose-salt solution (Earle"s balanced salt solution), asparagine (Asn) stimulates ornithine decarboxylase (ODC) activity in a dose-dependent manner, and the addition of epidermal growth factor (EGF) potentiates the effect of Asn.	Asparagine	61-71	ornithine decarboxylase 1	Homo sapiens	114-117
22157018-1	2012	In a glucose-salt solution (Earle"s balanced salt solution), asparagine (Asn) stimulates ornithine decarboxylase (ODC) activity in a dose-dependent manner, and the addition of epidermal growth factor (EGF) potentiates the effect of Asn.	Asparagine	73-76	ornithine decarboxylase 1	Homo sapiens	89-112
22157018-1	2012	In a glucose-salt solution (Earle"s balanced salt solution), asparagine (Asn) stimulates ornithine decarboxylase (ODC) activity in a dose-dependent manner, and the addition of epidermal growth factor (EGF) potentiates the effect of Asn.	Asparagine	73-76	ornithine decarboxylase 1	Homo sapiens	114-117
22157018-3	2012	Thus, the mechanism by which Asn activates ODC is important for understanding the regulation of ODC activity.	Asparagine	29-32	ornithine decarboxylase 1	Homo sapiens	43-46
22157018-3	2012	Thus, the mechanism by which Asn activates ODC is important for understanding the regulation of ODC activity.	Asparagine	29-32	ornithine decarboxylase 1	Homo sapiens	96-99
22105074-5	2012	Application of chimeric GLP-1/GIP peptides together with molecular modeling suggests that His(1) of GLP-1 interacts with Asn(302) of GLP1R and that Thr(7) of GLP-1 has close contact with a binding pocket formed by Ile(196), Leu(232), and Met(233) of GLP1R.	Asparagine	121-124	glucagon	Homo sapiens	100-105
22157018-5	2012	Among the amino acids tested, Asn and glutamine (Gln) effectively inhibited AZ1 expression, suggesting a differential role for amino acids in the regulation of ODC activity.	Asparagine	30-33	ornithine decarboxylase antizyme 1	Homo sapiens	76-79
22105074-5	2012	Application of chimeric GLP-1/GIP peptides together with molecular modeling suggests that His(1) of GLP-1 interacts with Asn(302) of GLP1R and that Thr(7) of GLP-1 has close contact with a binding pocket formed by Ile(196), Leu(232), and Met(233) of GLP1R.	Asparagine	121-124	glucagon like peptide 1 receptor	Homo sapiens	133-138
22157018-5	2012	Among the amino acids tested, Asn and glutamine (Gln) effectively inhibited AZ1 expression, suggesting a differential role for amino acids in the regulation of ODC activity.	Asparagine	30-33	ornithine decarboxylase 1	Homo sapiens	160-163
22157018-13	2012	Asn decreased the phosphorylation of mTOR-Ser(2448) and AKT-Ser(473), suggesting the inhibition of mTORC2.	Asparagine	0-3	mechanistic target of rapamycin kinase	Homo sapiens	37-41
22105074-5	2012	Application of chimeric GLP-1/GIP peptides together with molecular modeling suggests that His(1) of GLP-1 interacts with Asn(302) of GLP1R and that Thr(7) of GLP-1 has close contact with a binding pocket formed by Ile(196), Leu(232), and Met(233) of GLP1R.	Asparagine	121-124	glucagon	Homo sapiens	100-105
22157018-13	2012	Asn decreased the phosphorylation of mTOR-Ser(2448) and AKT-Ser(473), suggesting the inhibition of mTORC2.	Asparagine	0-3	CREB regulated transcription coactivator 2	Mus musculus	99-105
22057274-6	2012	In support of our structural data, we demonstrate that substitution of three N-terminal residues (Gly-19, His-25, and Phe-26) of FGF2 (a ligand that does not bind FGFR2b) for the corresponding residues of FGF1 (Phe-16, Asn-22, and Tyr-23) enables the FGF2 triple mutant to bind and activate FGFR2b.	Asparagine	219-222	fibroblast growth factor 1	Homo sapiens	205-209
22243962-1	2012	Legumain or asparaginly endopeptidase (AEP) is a lysosomal cysteine protease with a high level of specificity for cleavage of protein substrates after an asparagine residue.	Asparagine	154-164	legumain	Mus musculus	0-8
22052239-7	2012	Two out of 86 cases revealed a 130th codon G&gt;A missense mutation in exon 8 of PTEN which resulted in an Arg change to Gln in the PTEN protein structure; and a 334th codon A&gt;T missense mutation in exon 8 of PTEN, which resulted in an Asn change to Lys in the PTEN protein structure.	Asparagine	239-242	phosphatase and tensin homolog	Homo sapiens	81-85
22240840-5	2012	An immunoblot analysis of whole cell lysate (S9) fractions with or without treatment with an endoglycosidase revealed that UGT2B7 was N-glycosylated at Asn-68 and Asn-315 but not Asn-67.	Asparagine	152-155	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	123-129
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Asparagine	68-71	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Asparagine	141-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Asparagine	141-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Asparagine	141-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
21983135-4	2012	Substitution of Asn and Ser at positions 309 and 313, respectively, with alanine increased the affinity of C-CPE for claudin-4.	Asparagine	16-19	carboxypeptidase E	Mus musculus	109-112
21983135-4	2012	Substitution of Asn and Ser at positions 309 and 313, respectively, with alanine increased the affinity of C-CPE for claudin-4.	Asparagine	16-19	claudin 4	Mus musculus	117-126
22240840-5	2012	An immunoblot analysis of whole cell lysate (S9) fractions with or without treatment with an endoglycosidase revealed that UGT2B7 was N-glycosylated at Asn-68 and Asn-315 but not Asn-67.	Asparagine	163-166	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	123-129
22240840-5	2012	An immunoblot analysis of whole cell lysate (S9) fractions with or without treatment with an endoglycosidase revealed that UGT2B7 was N-glycosylated at Asn-68 and Asn-315 but not Asn-67.	Asparagine	163-166	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	123-129
21956730-4	2012	By generating recombinant refolded iNKT-cell TCRs, we show that natural single-nucleotide variations in iNKTalpha, translating to serine, threonine, asparagine or isoleucine at p93, exert a powerful effect on CD1d binding, with up to 28-fold differences in affinity between these variants.	Asparagine	149-159	CD1d molecule	Homo sapiens	209-213
23291850-1	2012	L-asparaginase (L-Asp) is an important reagent for acute lymphoblastic leukemia because asparagine is required for the malignant growth of tumor cells, especially lymphoblastic leukemia cells.	Asparagine	88-98	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
21744114-4	2012	A non-synonymous substitution at codon position 326 appeared to be differentially fixed in each species, asparagine for M. mulatta whereas tyrosine for M. fuscata, and may contribute to certain functional properties because it locates in the region contributing to ligand binding and interaction with dimerization partner of TLR2-TLR1 heterodimeric complex.	Asparagine	105-115	toll like receptor 2	Macaca mulatta	325-329
22904671-6	2012	Each monomer of the Aqy1 tetramers forms a channel whose walls consist mostly of hydrophilic residues, transporting through the selectivity filter containing Arg-227, His-212, Phe-92, and Ala-221, and the two conserved Asn-Pro-Ala (NPA) motifs containing asparagines 224 and 112.	Asparagine	255-266	Aqy1p	Saccharomyces cerevisiae S288C	20-24
22942686-1	2012	Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N(2) fixation, photorespiration or asparagine breakdown.	Asparagine	158-168	glutamate-ammonia ligase	Homo sapiens	0-20
23291850-1	2012	L-asparaginase (L-Asp) is an important reagent for acute lymphoblastic leukemia because asparagine is required for the malignant growth of tumor cells, especially lymphoblastic leukemia cells.	Asparagine	88-98	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-21
23250440-5	2012	All-Asn and all-Gln versions of Sup35 were protected from aggregation by PfHsp110c, suggesting that this chaperone is not limited to handling runs of asparagine.	Asparagine	150-160	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	32-37
24349908-2	2012	Residues more susceptible to MALDI-ISD, namely Xxx-Asp/Asn and Gly-Xxx, were identified from the discontinuous intense peak of c"-ions originating from specific cleavage at N-Calpha bonds of the backbone of equine cytochrome c.	Asparagine	55-58	cytochrome c, somatic	Equus caballus	214-226
24349908-5	2012	The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c"-ions originating from N-Calpha bond cleavage at Xxx-Asp/Asn and Gly-Xxx residues, but also C-terminal side complement z"-ions originating from the same cleavage sites.	Asparagine	143-146	cytochrome c, somatic	Equus caballus	33-45
22936990-4	2012	By contrast, among the four mutants at residue Val247 (TM6.40), replacing Val247 with Ala (V247A) and Asn (V247N) led to constitutive activation of mutant receptors when cotransfected with Galpha(15).	Asparagine	102-105	G protein subunit alpha 15	Homo sapiens	189-199
23077523-4	2012	Based on the structure of IDE, Asn 575 was identified as a potential hydrogen bond partner for Cys904 and mutation of this residue also reduced activity and decreased polyanion activation.	Asparagine	31-34	insulin degrading enzyme	Rattus norvegicus	26-29
23285087-4	2012	In the present study, we substituted asparagine residues that are possibly involved in N-glycosylation with glutamine residues and identified three glycosylation sites (Asn134, Asn503 and Asn516) within the structure of OATP1B1, an OATP member that is mainly expressed in the human liver.	Asparagine	37-47	solute carrier organic anion transporter family member 1B1	Homo sapiens	220-227
23285087-4	2012	In the present study, we substituted asparagine residues that are possibly involved in N-glycosylation with glutamine residues and identified three glycosylation sites (Asn134, Asn503 and Asn516) within the structure of OATP1B1, an OATP member that is mainly expressed in the human liver.	Asparagine	37-47	solute carrier organic anion transporter family member 1A2	Homo sapiens	220-224
23185472-1	2012	For mammalian TRPM8, the amino acid residues asparagine-799 and aspartate-802 are essential for the stimulation of the channel by the synthetic agonist icilin.	Asparagine	45-55	transient receptor potential cation channel subfamily M member 8	Homo sapiens	14-19
22916199-4	2012	Computational docking analysis and mutagenesis study revealed that compound 16 interacted with Asparagine 209 (Asn(209)) residue flanking the catalytic pocket of NAAA so as to block the substrate entrance.	Asparagine	95-105	N-acylethanolamine acid amidase	Mus musculus	162-166
22916199-4	2012	Computational docking analysis and mutagenesis study revealed that compound 16 interacted with Asparagine 209 (Asn(209)) residue flanking the catalytic pocket of NAAA so as to block the substrate entrance.	Asparagine	111-114	N-acylethanolamine acid amidase	Mus musculus	162-166
22389722-1	2012	Secretory human prostatic acid phosphatase (hPAP) is glycosylated at three asparagine residues (N62, N188, N301) and has potent antinociceptive effects when administered to mice.	Asparagine	75-85	acid phosphatase 3	Homo sapiens	16-42
22389722-1	2012	Secretory human prostatic acid phosphatase (hPAP) is glycosylated at three asparagine residues (N62, N188, N301) and has potent antinociceptive effects when administered to mice.	Asparagine	75-85	PDGFA associated protein 1	Homo sapiens	44-48
22253794-4	2012	In cells lacking [PIN+], toxicity of mutant htt was due to the polymerization and inactivation of the essential glutamine/asparagine-rich Sup35 protein and related inactivation of another essential protein, Sup45, most probably via its sequestration into Sup35 aggregates.	Asparagine	122-132	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	138-143
22412906-5	2012	Like many family B GPCRs, both the GIP and GLP-1 receptors possess a large extracellular N-terminus with multiple consensus sites for Asn-linked (N)-glycosylation.	Asparagine	134-137	gastric inhibitory polypeptide	Homo sapiens	35-38
22412906-5	2012	Like many family B GPCRs, both the GIP and GLP-1 receptors possess a large extracellular N-terminus with multiple consensus sites for Asn-linked (N)-glycosylation.	Asparagine	134-137	glucagon	Homo sapiens	43-48
21989967-7	2012	The structure of the Aib-Gly turn containing hairpin was determined by NMR and was shown to be like trpzip2 (Asn-Gly turn) as regards turn and strand geometries, but to differ from trpzip1 (Gly-Asn turn).	Asparagine	109-112	ANIB1	Homo sapiens	21-24
22116617-6	2012	Nucleotide sequence analysis of paternal beta3 revealed a single nucleotide exchange (G(1818)T) in exon 11 of the beta3 gene (ITGB3), changing Lys(580) (wild-type) to Asn(580) (Sec(a)).	Asparagine	167-170	integrin beta-3	Cricetulus griseus	126-131
22006924-8	2011	Thus, the Asn-260 glycan in the gp120 envelope of HIV-1 represents a hot spot for targeting suicidal drugs or antibodies in a therapeutic effort to efficiently neutralize a broad array of virus strains.	Asparagine	10-13	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	32-37
22106309-4	2011	However, our results show that GLS1 differs from PFKFB3 in that its recognition by APC/C-Cdh1 requires the presence of both a Lys-Glu-Asn box (KEN box) and a destruction box (D box) rather than a KEN box alone.	Asparagine	134-137	glutaminase	Homo sapiens	31-35
22006924-0	2011	The highly conserved glycan at asparagine 260 of HIV-1 gp120 is indispensable for viral entry.	Asparagine	31-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	55-60
21945257-1	2011	West Nile virus (WNV), like all members of the Japanese encephalitis (JE) serogroup except JE virus, contains three N-linked glycosylation (N-X-S/T) sites in the NS1 protein at asparagine residues NS1(130), NS1(175) and NS1(207).	Asparagine	177-187	influenza virus NS1A binding protein	Mus musculus	162-165
21945257-8	2011	Overall, we showed that changing the asparagine of the NS1(130) glycosylation motif to a serine or glutamine attenuated WNV further than the asparagine to alanine substitution.	Asparagine	37-47	influenza virus NS1A binding protein	Mus musculus	55-58
21945257-8	2011	Overall, we showed that changing the asparagine of the NS1(130) glycosylation motif to a serine or glutamine attenuated WNV further than the asparagine to alanine substitution.	Asparagine	141-151	influenza virus NS1A binding protein	Mus musculus	55-58
21945257-9	2011	Further, mutating all three of the amino acids of the NS1(130-132) glycosylation motif (NTT-QQA) along with NS1(175) and NS1(207) asparagine to alanine mutations gave the most stable and attenuated strain.	Asparagine	130-140	influenza virus NS1A binding protein	Mus musculus	54-57
21914807-6	2011	A single asparagine in TMD4 of PS1 is involved in a protein-protein interaction by binding to another asparagine in Pen2.	Asparagine	9-19	presenilin 1	Homo sapiens	31-34
21967851-0	2011	Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.	Asparagine	36-39	myeloperoxidase	Homo sapiens	53-68
21807096-7	2011	N-terminal sequencing analysis showed that calpain cleaves VGLUT2 in the C-terminus, at Asn(534) and Lys(542).	Asparagine	88-91	solute carrier family 17 member 6	Homo sapiens	59-65
21908619-8	2011	A comparison of the structures of the catalytic sites of GCP2 and GCP3, as well as mutagenesis experiments revealed that a single amino acid substitution (Asn-519 in GCP2, Ser-509 in GCP3) is largely responsible for GCP3 being able to hydrolyze beta-citrylglutamate.	Asparagine	155-158	folate hydrolase 1	Mus musculus	57-61
21908619-8	2011	A comparison of the structures of the catalytic sites of GCP2 and GCP3, as well as mutagenesis experiments revealed that a single amino acid substitution (Asn-519 in GCP2, Ser-509 in GCP3) is largely responsible for GCP3 being able to hydrolyze beta-citrylglutamate.	Asparagine	155-158	N-acetylated alpha-linked acidic dipeptidase 2	Mus musculus	66-70
21908619-8	2011	A comparison of the structures of the catalytic sites of GCP2 and GCP3, as well as mutagenesis experiments revealed that a single amino acid substitution (Asn-519 in GCP2, Ser-509 in GCP3) is largely responsible for GCP3 being able to hydrolyze beta-citrylglutamate.	Asparagine	155-158	folate hydrolase 1	Mus musculus	166-170
21939771-8	2011	CsCatL has an N-terminal cathepsin propeptide inhibitor domain followed by a Papain family cysteine protease domain, the latter containing four conserved catalytic residues: Gln-133, Cys-139, His-279, and Asn-303.	Asparagine	205-208	cathepsin L	Cynoglossus semilaevis	0-6
21972289-10	2011	The ATF5-regulated increase in ASNS expression in response to more efficacious E coli-induced asparagine depletion may explain our observed results.	Asparagine	94-104	activating transcription factor 5	Homo sapiens	4-8
21972289-10	2011	The ATF5-regulated increase in ASNS expression in response to more efficacious E coli-induced asparagine depletion may explain our observed results.	Asparagine	94-104	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	31-35
21832048-7	2011	More specifically, nAChR halpha6 subunit residues Asn-143 and Met-145 are important for dominant-negative effects of nAChR hbeta3 subunits on halpha6hbeta4-nAChR function.	Asparagine	50-53	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	19-24
21832048-7	2011	More specifically, nAChR halpha6 subunit residues Asn-143 and Met-145 are important for dominant-negative effects of nAChR hbeta3 subunits on halpha6hbeta4-nAChR function.	Asparagine	50-53	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	117-122
21832048-7	2011	More specifically, nAChR halpha6 subunit residues Asn-143 and Met-145 are important for dominant-negative effects of nAChR hbeta3 subunits on halpha6hbeta4-nAChR function.	Asparagine	50-53	potassium calcium-activated channel subfamily M regulatory beta subunit 3	Homo sapiens	123-129
21832048-7	2011	More specifically, nAChR halpha6 subunit residues Asn-143 and Met-145 are important for dominant-negative effects of nAChR hbeta3 subunits on halpha6hbeta4-nAChR function.	Asparagine	50-53	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	117-122
21832048-8	2011	Asn-143 and additional residues in the N-terminal domain of nAChR halpha6 subunits are involved in the gain-of-function effects of nAChR hbeta3(V9"S) subunits on alpha6beta2*-nAChR function.	Asparagine	0-3	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	60-65
21832048-8	2011	Asn-143 and additional residues in the N-terminal domain of nAChR halpha6 subunits are involved in the gain-of-function effects of nAChR hbeta3(V9"S) subunits on alpha6beta2*-nAChR function.	Asparagine	0-3	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	131-136
21832048-8	2011	Asn-143 and additional residues in the N-terminal domain of nAChR halpha6 subunits are involved in the gain-of-function effects of nAChR hbeta3(V9"S) subunits on alpha6beta2*-nAChR function.	Asparagine	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 3	Homo sapiens	137-143
21832048-8	2011	Asn-143 and additional residues in the N-terminal domain of nAChR halpha6 subunits are involved in the gain-of-function effects of nAChR hbeta3(V9"S) subunits on alpha6beta2*-nAChR function.	Asparagine	0-3	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	131-136
21908619-8	2011	A comparison of the structures of the catalytic sites of GCP2 and GCP3, as well as mutagenesis experiments revealed that a single amino acid substitution (Asn-519 in GCP2, Ser-509 in GCP3) is largely responsible for GCP3 being able to hydrolyze beta-citrylglutamate.	Asparagine	155-158	N-acetylated alpha-linked acidic dipeptidase 2	Mus musculus	183-187
21908619-8	2011	A comparison of the structures of the catalytic sites of GCP2 and GCP3, as well as mutagenesis experiments revealed that a single amino acid substitution (Asn-519 in GCP2, Ser-509 in GCP3) is largely responsible for GCP3 being able to hydrolyze beta-citrylglutamate.	Asparagine	155-158	N-acetylated alpha-linked acidic dipeptidase 2	Mus musculus	183-187
21914807-6	2011	A single asparagine in TMD4 of PS1 is involved in a protein-protein interaction by binding to another asparagine in Pen2.	Asparagine	9-19	presenilin enhancer, gamma-secretase subunit	Homo sapiens	116-120
21914807-6	2011	A single asparagine in TMD4 of PS1 is involved in a protein-protein interaction by binding to another asparagine in Pen2.	Asparagine	102-112	presenilin 1	Homo sapiens	31-34
21914807-6	2011	A single asparagine in TMD4 of PS1 is involved in a protein-protein interaction by binding to another asparagine in Pen2.	Asparagine	102-112	presenilin enhancer, gamma-secretase subunit	Homo sapiens	116-120
21932778-3	2011	Here, we studied the role of the possible N-glycosylation sites at Asn-79 and Asn-116 in recombinant anchorless glypican-1 expressed in eukaryotic cells.	Asparagine	67-70	glypican 1	Homo sapiens	112-122
21945531-4	2011	We mapped the glycosylation sites of ERMES and demonstrate that three asparagine residues in the N-terminal domain of Mmm1 are glycosylated.	Asparagine	70-80	ERMES complex subunit MMM1	Saccharomyces cerevisiae S288C	118-122
21932778-3	2011	Here, we studied the role of the possible N-glycosylation sites at Asn-79 and Asn-116 in recombinant anchorless glypican-1 expressed in eukaryotic cells.	Asparagine	78-81	glypican 1	Homo sapiens	112-122
21975069-3	2011	A homology model of hMCHR1 suggests that these compounds interact with Asn 294 and Asp 123 in the binding site of hMCHR1 to enhance binding affinity.	Asparagine	71-74	melanin concentrating hormone receptor 1	Homo sapiens	20-26
21975069-3	2011	A homology model of hMCHR1 suggests that these compounds interact with Asn 294 and Asp 123 in the binding site of hMCHR1 to enhance binding affinity.	Asparagine	71-74	melanin concentrating hormone receptor 1	Homo sapiens	114-120
21900944-2	2011	Sequencing of GOT1 revealed an in-frame deletion of three nucleic acids encoding asparagine at position 389 c.1165_1167delAAC (p.Asn389del) in the gene.	Asparagine	81-91	glutamic-oxaloacetic transaminase 1	Homo sapiens	14-18
21920023-0	2011	Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity.	Asparagine	0-10	chymotrypsin C	Homo sapiens	41-55
21920023-3	2011	The aim of the present study was to determine whether human CTRC undergoes asparagine-linked (N-linked) glycosylation and to examine the role of this modification in CTRC folding and function.	Asparagine	75-85	chymotrypsin C	Homo sapiens	60-64
21920023-4	2011	We abolished potential sites of N-linked glycosylation (Asn-Xaa-Ser/Thr) in human CTRC by mutating the Asn residues to Ser individually or in combination, expressed the CTRC mutants in HEK 293T cells and determined their glycosylation state using PNGase F and endo H digestion.	Asparagine	56-59	chymotrypsin C	Homo sapiens	82-86
21920023-4	2011	We abolished potential sites of N-linked glycosylation (Asn-Xaa-Ser/Thr) in human CTRC by mutating the Asn residues to Ser individually or in combination, expressed the CTRC mutants in HEK 293T cells and determined their glycosylation state using PNGase F and endo H digestion.	Asparagine	103-106	chymotrypsin C	Homo sapiens	82-86
21976137-10	2011	The L5 peptide with 14 amino acids (Arg-Leu-Asn-Val-Gly-Gly-Thr-Tyr-Phe-Leu-Thr-Thr-Arg-Gln) showed selective binding to the GPC-3-expressing tumor cells, as did a shortened L5 peptide (L5-2) with seven amino acids (Tyr-Phe-Leu-Thr-Thr-Arg-Gln).	Asparagine	44-47	glypican 3	Homo sapiens	125-130
21971186-4	2011	Our group has identified a single point mutation from asparagine (N) to serine (S) at position 66 in the PB1-F2 protein that dramatically increases the virulence of highly pathogenic avian H5N1 influenza viruses and of the 1918 pandemic strain.	Asparagine	54-64	polybromo 1	Mus musculus	105-108
21852240-2	2011	This process involves the transfer of a preassembled oligosaccharide from a lipid donor to asparagine side chains of polypeptides and is catalyzed by the membrane-bound oligosaccharyltransferase (OST).	Asparagine	91-101	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	196-199
21877723-3	2011	In betaB2-crystallin, which is the most abundant beta-crystallin, the deamidation of asparagine and glutamine residues has been reported.	Asparagine	85-95	crystallin beta B2	Homo sapiens	3-20
21752865-0	2011	Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.	Asparagine	25-35	integral membrane protein 2B	Homo sapiens	17-21
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Asparagine	278-281	TANK binding kinase 1	Homo sapiens	92-95
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Asparagine	278-281	TANK binding kinase 1	Homo sapiens	176-179
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Asparagine	278-281	TANK binding kinase 1	Homo sapiens	176-179
21752865-4	2011	In support, bioinformatics analysis indicated that BRI2 bears the consensus sequence Asn-Thr-Ser (residues 170-173) and could be N-glycosylated at Asn170.	Asparagine	85-88	integral membrane protein 2B	Homo sapiens	51-55
21733844-3	2011	Here we overproduced hAQP10 in the yeast Pichia pastoris and observed that the protein is glycosylated at Asn-133 in the extracellular loop C. This finding confirms one of three predicted glycosylation sites for hAQP10, and its glycosylation is unique for the human aquaporins overproduced in this host.	Asparagine	106-109	aquaporin 10	Homo sapiens	21-27
21640146-2	2011	The tumor vasculature-specific ligand asparagine-glycine-arginine (NGR) peptide targets the isoform of aminopeptidase N (APN, also referred to as CD13) that is expressed on the endothelial cells in angiogenic vessels such as the neovasculature in tumors.	Asparagine	38-48	reticulon 4 receptor	Homo sapiens	67-70
21640146-2	2011	The tumor vasculature-specific ligand asparagine-glycine-arginine (NGR) peptide targets the isoform of aminopeptidase N (APN, also referred to as CD13) that is expressed on the endothelial cells in angiogenic vessels such as the neovasculature in tumors.	Asparagine	38-48	alanyl aminopeptidase, membrane	Homo sapiens	103-119
21640146-2	2011	The tumor vasculature-specific ligand asparagine-glycine-arginine (NGR) peptide targets the isoform of aminopeptidase N (APN, also referred to as CD13) that is expressed on the endothelial cells in angiogenic vessels such as the neovasculature in tumors.	Asparagine	38-48	alanyl aminopeptidase, membrane	Homo sapiens	121-124
21640146-2	2011	The tumor vasculature-specific ligand asparagine-glycine-arginine (NGR) peptide targets the isoform of aminopeptidase N (APN, also referred to as CD13) that is expressed on the endothelial cells in angiogenic vessels such as the neovasculature in tumors.	Asparagine	38-48	alanyl aminopeptidase, membrane	Homo sapiens	146-150
21849674-7	2011	We also investigate the molecular mechanisms controlling NKp46 interactions with its beta cell ligand and demonstrate that the recognition is confined to the membrane proximal domain and stalk region of NKp46 and that two glycosylated residues of NKp46, Thr(125) and Asn(216), are critical for this recognition.	Asparagine	267-270	natural cytotoxicity triggering receptor 1	Homo sapiens	57-62
21708292-7	2011	There was a single Histidine to Asparagine substitution in the 131st position which is a part of 120 loop on HA1 region along with a deletion at position 178 in the Kolkata strains belonging to the Yamagata lineage.	Asparagine	32-42	Rho GTPase activating protein 45	Homo sapiens	109-112
21816159-2	2011	The silkworm Bombyx mori encodes four isoforms of GST Omega (GSTO), featured with a catalytic cysteine, except that bmGSTO3-3 has an asparagine substitution of this catalytic residue.	Asparagine	133-143	glutathione S-transferase omega 3	Bombyx mori	116-125
21768116-1	2011	The oligosaccharyltransferase complex catalyzes the transfer of oligosaccharide from a dolichol pyrophosphate donor en bloc onto a free asparagine residue of a newly synthesized nascent chain during the translocation in the endoplasmic reticulum lumen.	Asparagine	136-146	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	4-29
21730057-0	2011	A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport.	Asparagine	12-22	solute carrier family 6 member 4	Homo sapiens	67-88
21770429-11	2011	This mostly deglycosylated variant had the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn(196) glycosylation in IL5Ralpha function.	Asparagine	166-169	interleukin 5 receptor subunit alpha	Homo sapiens	118-127
21770429-11	2011	This mostly deglycosylated variant had the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn(196) glycosylation in IL5Ralpha function.	Asparagine	166-169	interleukin 5 receptor subunit alpha	Homo sapiens	192-201
21859446-7	2011	Substitution of the asparagine at codon 348 in the p51 subunit with either isoleucine or leucine abrogated the observed protein-RNA interaction, thus, providing a possible explanation for the decreased RNase H phenotype.	Asparagine	20-30	tumor protein p63	Homo sapiens	51-54
21651995-1	2011	Research carried out up to 3 decades ago by Gracy and co-workers revealed that the activity of the glycolytic enzyme triosephosphate isomerase (TPI), which converts dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G3P), gradually declines whilst carrying out its catalytic function, primarily due to deamidation of certain asparagine residues.	Asparagine	339-349	triosephosphate isomerase 1	Homo sapiens	117-142
21651995-1	2011	Research carried out up to 3 decades ago by Gracy and co-workers revealed that the activity of the glycolytic enzyme triosephosphate isomerase (TPI), which converts dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G3P), gradually declines whilst carrying out its catalytic function, primarily due to deamidation of certain asparagine residues.	Asparagine	339-349	triosephosphate isomerase 1	Homo sapiens	144-147
21764973-6	2011	Docking studies with a Suc2 modeled structure defined a putative acceptor substrate binding subsite constituted by Trp 291 and Asn 228.	Asparagine	127-130	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	23-27
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Asparagine	35-45	protein inhibitor of activated STAT 3	Homo sapiens	87-92
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Asparagine	35-45	signal transducer and activator of transcription 3	Homo sapiens	115-120
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Asparagine	35-45	protein inhibitor of activated STAT 3	Homo sapiens	121-126
22007496-8	2011	The mutation of nt14319T --&gt; C, which not being reported previously, locate in the region of ND6 subunit, causing amino acid change (asparagine --&gt; aspartic acid).	Asparagine	136-146	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	96-99
20354818-6	2011	Overall, significantly elevated lung cancer risk was associated with XPD Asn allele when all studies were pooled into the meta-analysis (Asn/Asn vs. Asp/Asp: OR=1.158, 95% CI=1.018-1.317; recessive model: OR=1.161, 95% CI=1.029-1.311).	Asparagine	73-76	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	69-72
20354818-6	2011	Overall, significantly elevated lung cancer risk was associated with XPD Asn allele when all studies were pooled into the meta-analysis (Asn/Asn vs. Asp/Asp: OR=1.158, 95% CI=1.018-1.317; recessive model: OR=1.161, 95% CI=1.029-1.311).	Asparagine	137-140	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	69-72
20354818-6	2011	Overall, significantly elevated lung cancer risk was associated with XPD Asn allele when all studies were pooled into the meta-analysis (Asn/Asn vs. Asp/Asp: OR=1.158, 95% CI=1.018-1.317; recessive model: OR=1.161, 95% CI=1.029-1.311).	Asparagine	137-140	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	69-72
20354818-9	2011	In conclusion, this meta-analysis suggests that the XPD Asn allele is a low-penetrant risk factor for developing lung cancer.	Asparagine	56-59	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	52-55
21835055-5	2011	RESULTS: We detected a heterozygous mutation in the first extracellular loop of the TSHR gene leading to an exchange of an isoleucine residue for asparagine at amino acid position 486 (I486N).	Asparagine	146-156	thyroid stimulating hormone receptor	Homo sapiens	84-88
21712391-0	2011	Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95.	Asparagine	104-114	inactive glutathione hydrolase 2	Homo sapiens	32-61
21683950-9	2011	Asparagine at residue 400 is highly conserved and its substitution by serine predicted to alter critical interactions that stabilize LHCGR.	Asparagine	0-10	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	133-138
21570947-4	2011	Studies utilizing site-directed mutagenesis revealed that the N-glycosylation sites at positions Asn(138) and Asn(489) are important for the function of hSMVT and that mutating these sites significantly reduces the V(max) of the biotin uptake process.	Asparagine	97-100	solute carrier family 5 member 6	Homo sapiens	153-158
21570947-4	2011	Studies utilizing site-directed mutagenesis revealed that the N-glycosylation sites at positions Asn(138) and Asn(489) are important for the function of hSMVT and that mutating these sites significantly reduces the V(max) of the biotin uptake process.	Asparagine	110-113	solute carrier family 5 member 6	Homo sapiens	153-158
21302115-11	2011	Molecular analysis revealed a novel missense mutation 825 G C predicting 275 Lys Asn causing G6PD Bangkok.	Asparagine	81-84	glucose-6-phosphate dehydrogenase	Homo sapiens	93-97
21614585-2	2011	In the central reaction of the pathway, oligosaccharyltransferase (OST), a multimeric complex located at the membrane of the endoplasmic reticulum, transfers a preassembled oligosaccharide to selected asparagine residues within the consensus sequence asparagine-X-serine/threonine.	Asparagine	201-211	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	40-65
21614585-2	2011	In the central reaction of the pathway, oligosaccharyltransferase (OST), a multimeric complex located at the membrane of the endoplasmic reticulum, transfers a preassembled oligosaccharide to selected asparagine residues within the consensus sequence asparagine-X-serine/threonine.	Asparagine	201-211	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	67-70
21669976-4	2011	Our results show that KCNE1 is exclusively O-glycosylated at Thr-7, which is also required for N-glycosylation at Asn-5.	Asparagine	114-117	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	22-27
21670269-5	2011	In addition, it contains two aspartate residues that replace the asparagines encoded in the tyrosinase sequence.	Asparagine	65-76	tyrosinase	Homo sapiens	92-102
21670269-6	2011	We confirmed that this peptide is naturally presented at the surface of melanoma cells, and we showed that its processing sequentially requires translation of tyrosinase into the endoplasmic reticulum and its retrotranslocation into the cytosol, where deglycosylation of the two asparagines by peptide-N-glycanase turns them into aspartates by deamidation.	Asparagine	279-290	tyrosinase	Homo sapiens	159-169
21763482-4	2011	Exome analysis suggests that an aspartic-acid-to-asparagine mutation within vacuolar protein sorting 35 (VPS35 c.1858G>A; p.Asp620Asn) is the genetic determinant of disease.	Asparagine	49-59	VPS35 retromer complex component	Homo sapiens	105-110
21729333-6	2011	RESULTS: This analysis and two new crystal structures suggest that Ire1 RNase uses histidine H1061 and tyrosine Y1043 as the general acid-general base pair contributing &gt;=7.6 kcal/mol and 1.4 kcal/mol to transition state stabilization, respectively, and asparagine N1057 and arginine R1056 for coordination of the scissile phosphate.	Asparagine	257-267	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	67-71
21609714-1	2011	Oligosaccharyltransferase (OST) is a membrane associated enzyme complex that mediates transfer of an oligosaccharide onto asparagine residue of a protein.	Asparagine	122-132	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
21714819-5	2011	In GABRA1, two mutations were found, with the first being a 25-bp insertion that was associated with intron retention (i.e. K353delins18X) and the second corresponding to a single point mutation that replaced the aspartate 219 residue with an asparagine (i.e. D219N).	Asparagine	243-253	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	3-9
21511948-0	2011	The G82S polymorphism promotes glycosylation of the receptor for advanced glycation end products (RAGE) at asparagine 81: comparison of wild-type rage with the G82S polymorphic variant.	Asparagine	107-117	advanced glycosylation end-product specific receptor	Homo sapiens	98-102
21511948-11	2011	Furthermore, RAGE binding to S100B ligand is affected by Asn(81) glycosylation, with consequences for NF-kappaB activation.	Asparagine	57-60	advanced glycosylation end-product specific receptor	Homo sapiens	13-17
21511948-11	2011	Furthermore, RAGE binding to S100B ligand is affected by Asn(81) glycosylation, with consequences for NF-kappaB activation.	Asparagine	57-60	S100 calcium binding protein B	Homo sapiens	29-34
21511948-12	2011	Therefore, the G82S polymorphism promotes N-linked glycosylation of Asn(81), which has implications for the structure of the ligand binding region of RAGE and might explain the enhanced function associated with the G82S polymorphic RAGE variant.	Asparagine	68-71	advanced glycosylation end-product specific receptor	Homo sapiens	150-154
21511948-12	2011	Therefore, the G82S polymorphism promotes N-linked glycosylation of Asn(81), which has implications for the structure of the ligand binding region of RAGE and might explain the enhanced function associated with the G82S polymorphic RAGE variant.	Asparagine	68-71	advanced glycosylation end-product specific receptor	Homo sapiens	232-236
21105990-1	2011	OBJECTIVE: To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones.	Asparagine	41-44	follicle stimulating hormone receptor	Homo sapiens	132-137
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	46-49	follicle stimulating hormone receptor	Homo sapiens	4-9
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	50-53	follicle stimulating hormone receptor	Homo sapiens	4-9
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	50-53	follicle stimulating hormone receptor	Homo sapiens	4-9
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	50-53	follicle stimulating hormone receptor	Homo sapiens	4-9
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	50-53	follicle stimulating hormone receptor	Homo sapiens	4-9
21105990-6	2011	The FSH-R genotype at position 680 was 49.4% (Asn/Asn), 41.9% (Asn/Ser), and 8.7% (Ser/Ser) in the control group and 40.1% (Asn/Asn), 46.5% (Asn/Ser), and 13.4% (Ser/Ser) in infertile men, respectively (P &gt; 0.05, chi-squared test).	Asparagine	50-53	follicle stimulating hormone receptor	Homo sapiens	4-9
21769758-11	2011	Wild-type adiponectin protein migrated as double bands, and mutant adiponectin in either asparagine at position 53 or threonine at 55 lacked slower band.	Asparagine	89-99	adiponectin, C1Q and collagen domain containing	Mus musculus	67-78
21769758-12	2011	These results suggest that a part of mouse adiponectin is modified by N-linked glycosylation at asparagine 53.	Asparagine	96-106	adiponectin, C1Q and collagen domain containing	Mus musculus	43-54
21543315-3	2011	In this work, sequence alignments of hSBDb with the E3-binding domain (E3BD) of the mammalian pyruvate dehydrogenase complex show that hSBDb has an arginine at position 118, where E3BD features an asparagine.	Asparagine	197-207	dihydrolipoamide dehydrogenase	Homo sapiens	52-54
21543315-9	2011	Solution NMR data corroborated the interactions of hE3 with Arg-118 and Asn-118 in wild-type hSBDb and mutant hSBDb*, respectively.	Asparagine	72-75	dihydrolipoamide dehydrogenase	Homo sapiens	51-54
21502316-1	2011	A novel double deletion in cardiac troponin T (cTnT) of two highly conserved amino acids (Asn-100 and Glu-101) was found in a restrictive cardiomyopathic (RCM) pediatric patient.	Asparagine	90-93	troponin T2, cardiac type	Homo sapiens	27-45
21502316-1	2011	A novel double deletion in cardiac troponin T (cTnT) of two highly conserved amino acids (Asn-100 and Glu-101) was found in a restrictive cardiomyopathic (RCM) pediatric patient.	Asparagine	90-93	troponin T2, cardiac type	Homo sapiens	47-51
21609714-1	2011	Oligosaccharyltransferase (OST) is a membrane associated enzyme complex that mediates transfer of an oligosaccharide onto asparagine residue of a protein.	Asparagine	122-132	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
21478159-0	2011	Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26.	Asparagine	0-10	gap junction protein beta 1	Homo sapiens	18-28
21606333-3	2011	Replacement of solution-exposed basic residues (K587, K589, R590, and R591) located on the front surface of gp5 with neutral asparagines abolishes the ability of gp5 and the helicase to mediate strand-displacement synthesis.	Asparagine	125-136	helicase	Escherichia phage T7	174-182
21478159-0	2011	Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26.	Asparagine	0-10	gap junction protein beta 2	Homo sapiens	125-135
21478159-10	2011	Both our modeling and experimental data suggest that Asn(175) of Cx32 is a critical residue for heterotypic docking and functional gap junction channel formation between the Cx32 and Cx26 hemichannels.	Asparagine	53-56	gap junction protein beta 1	Homo sapiens	65-69
21478159-10	2011	Both our modeling and experimental data suggest that Asn(175) of Cx32 is a critical residue for heterotypic docking and functional gap junction channel formation between the Cx32 and Cx26 hemichannels.	Asparagine	53-56	gap junction protein beta 1	Homo sapiens	174-178
21478159-10	2011	Both our modeling and experimental data suggest that Asn(175) of Cx32 is a critical residue for heterotypic docking and functional gap junction channel formation between the Cx32 and Cx26 hemichannels.	Asparagine	53-56	gap junction protein beta 2	Homo sapiens	183-187
21286706-2	2011	According to an early report, chicken Mx1 variants encoding Asn at position 631 have antiviral activity, whereas variants with Ser at 631 lack activity in experiments evaluating Mx1 complementary DNA (cDNA) expressed ectopically in a cell line.	Asparagine	60-63	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Gallus gallus	38-41
21413052-10	2011	Asparagine at residue 37, which was associated with PSC, induced a positive charge in pocket P9.	Asparagine	0-10	PSC	Homo sapiens	52-55
20822851-9	2011	Given the clear correlation between the depth of asparagine depletion and the patient outcome, asparaginase therapy should be monitored for adequate asparagine depletion for achievement of optimum results.	Asparagine	49-59	asparaginase	Homo sapiens	95-107
21345800-9	2011	Furthermore, comparison of these mutant and wild type structures strongly suggests that the Gly(631)-Asn(635) loop movement controls NADPH binding and NADP(+) release; this loop movement in turn facilitates the flavin domain movement, allowing electron transfer from FMN to the CYPOR redox partners.	Asparagine	101-104	cytochrome p450 oxidoreductase	Homo sapiens	278-283
21244856-2	2011	It is presumed that all 19 mammalian Wnt family members contain two types of post-translational modification: the covalent attachment of fatty acids at two distinct positions, and the N-glycosylation of multiple asparagines.	Asparagine	212-223	Wnt family member 1	Homo sapiens	37-40
20822851-9	2011	Given the clear correlation between the depth of asparagine depletion and the patient outcome, asparaginase therapy should be monitored for adequate asparagine depletion for achievement of optimum results.	Asparagine	149-159	asparaginase	Homo sapiens	95-107
21384453-6	2011	Our data supports a model of Ost3/6p function in which they transiently bind stretches of nascent polypeptide substrate to inhibit protein folding, thereby increasing glycosylation efficiency at nearby asparagine residues.	Asparagine	202-212	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Saccharomyces cerevisiae S288C	29-36
21279647-6	2011	Concomitantly, it also increases the expression of asparagines synthetase 1 (ASN1) that shifts aspartate utilization towards asparagine formation.	Asparagine	51-61	asparagine synthase (glutamine-hydrolyzing) 1	Saccharomyces cerevisiae S288C	77-81
21402116-5	2011	In RAMP3, these were Trp, Phe, Tyr, Ala, Ser, Thr, Arg and Asn; in RAMP1, Glu, Phe, Tyr, Ala and Asn substitutions were made.	Asparagine	59-62	receptor activity modifying protein 3	Homo sapiens	3-8
21552498-7	2011	Sequencing of GJA3 revealed a G&gt;A transition at nucleotide position c.139, which causes an Asn substitution for the conservative Asp at codon 47 (P.D47N).This mutation is identified in all affected individuals but is not found in 100 control chromosomes.	Asparagine	94-97	gap junction protein alpha 3	Homo sapiens	14-18
21335549-8	2011	Hydroxylation at the three sites in endogenous human HIF-1alpha proteins was suppressed by hypoxia in the order Pro(402) &gt; Pro(564) &gt; Asn(803).	Asparagine	140-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
21375249-1	2011	The enzymatic deamidation of N-terminal L-Asn by N-terminal asparagine amidohydrolase (NTAN1) is a feature of the ubiquitin-dependent N-end rule pathway of protein degradation, which relates the in vivo half-life of a protein to the identity of its N-terminal residue.	Asparagine	40-45	N-terminal asparagine amidase	Homo sapiens	87-92
21349833-6	2011	We identify the primary cause of inhibition as a failure to activate the nucleotide base as an efficient leaving group and demonstrate that the higher binding affinity of AAG for epsilonC versus epsilonA is achieved through formation of an additional hydrogen bond between Asn-169 in the active site pocket and the O(2) of epsilonC.	Asparagine	273-276	N-methylpurine DNA glycosylase	Homo sapiens	171-174
21357684-2	2011	Oligosaccharyltransferase (OST) catalyzes the transfer of preassembled oligosaccharides on lipid carriers onto asparagine residues in polypeptide chains.	Asparagine	111-121	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
21357684-2	2011	Oligosaccharyltransferase (OST) catalyzes the transfer of preassembled oligosaccharides on lipid carriers onto asparagine residues in polypeptide chains.	Asparagine	111-121	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
21375249-3	2011	We show here that hNTAN1 is highly selective for the hydrolysis of N-terminal peptidyl L-Asn but fails to deamidate free L-Asn or L-Gln, N-terminal peptidyl L-Gln, or acetylated N-terminal peptidyl L-Asn.	Asparagine	87-92	N-terminal asparagine amidase	Homo sapiens	18-24
21375249-3	2011	We show here that hNTAN1 is highly selective for the hydrolysis of N-terminal peptidyl L-Asn but fails to deamidate free L-Asn or L-Gln, N-terminal peptidyl L-Gln, or acetylated N-terminal peptidyl L-Asn.	Asparagine	121-126	N-terminal asparagine amidase	Homo sapiens	18-24
21375249-3	2011	We show here that hNTAN1 is highly selective for the hydrolysis of N-terminal peptidyl L-Asn but fails to deamidate free L-Asn or L-Gln, N-terminal peptidyl L-Gln, or acetylated N-terminal peptidyl L-Asn.	Asparagine	121-126	N-terminal asparagine amidase	Homo sapiens	18-24
21332712-1	2011	l-asparaginase encapsulated within erythrocytes (GRASPA( ) ) should allow serum asparagine depletion over a longer period than the native form of the enzyme, using lower doses and allowing better tolerance.	Asparagine	80-90	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
21312285-5	2011	LRRK2-associated PD patients had a higher aSN than did nonmanifesting carriers (P = .011), but there was no significant difference in aSN between patients with idiopathic and LRRK2-associated PD (P = .439).	Asparagine	42-45	leucine rich repeat kinase 2	Homo sapiens	0-5
21289125-0	2011	Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab.	Asparagine	8-18	CD4 molecule	Homo sapiens	148-151
21301788-1	2011	A novel dysfibrinogenaemia with a replacement of Tyr by Asn at Bbeta41 has been discovered (fibrinogen Caracas VIII).	Asparagine	56-59	fibrinogen beta chain	Homo sapiens	11-21
21029261-3	2011	The aim of this study was to examine if the coding sequence polymorphism S100A2_185G&gt;A, leading to the peptide 62 substitution of asparagine (AAC, A allele) for serine (AGC, G allele) in helix III, had modulation effects on S100A-mediated tumor suppression.	Asparagine	133-143	S100 calcium binding protein A2	Homo sapiens	73-79
21029261-3	2011	The aim of this study was to examine if the coding sequence polymorphism S100A2_185G&gt;A, leading to the peptide 62 substitution of asparagine (AAC, A allele) for serine (AGC, G allele) in helix III, had modulation effects on S100A-mediated tumor suppression.	Asparagine	133-143	glycine-N-acyltransferase	Homo sapiens	145-148
21301788-1	2011	A novel dysfibrinogenaemia with a replacement of Tyr by Asn at Bbeta41 has been discovered (fibrinogen Caracas VIII).	Asparagine	56-59	cytochrome c oxidase subunit 8A	Homo sapiens	111-115
21411649-4	2011	We find that HCN1 and TRIP8b interact at two distinct sites: an upstream site where the C-linker/cyclic nucleotide-binding domain of HCN1 interacts with an 80 aa domain in the conserved central core of TRIP8b; and a downstream site where the C-terminal SNL (Ser-Asn-Leu) tripeptide of the channel interacts with the tetratricopeptide repeat domain of TRIP8b.	Asparagine	262-265	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	13-17
21383159-2	2011	UGT1 recognizes disordered or hydrophobic patches near asparagine-linked nonglucosylated glycans in partially misfolded glycoproteins and reglucosylates them, returning folding intermediates to the cycle.	Asparagine	55-65	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	0-4
21411649-4	2011	We find that HCN1 and TRIP8b interact at two distinct sites: an upstream site where the C-linker/cyclic nucleotide-binding domain of HCN1 interacts with an 80 aa domain in the conserved central core of TRIP8b; and a downstream site where the C-terminal SNL (Ser-Asn-Leu) tripeptide of the channel interacts with the tetratricopeptide repeat domain of TRIP8b.	Asparagine	262-265	peroxisomal biogenesis factor 5-like	Mus musculus	22-28
21411649-4	2011	We find that HCN1 and TRIP8b interact at two distinct sites: an upstream site where the C-linker/cyclic nucleotide-binding domain of HCN1 interacts with an 80 aa domain in the conserved central core of TRIP8b; and a downstream site where the C-terminal SNL (Ser-Asn-Leu) tripeptide of the channel interacts with the tetratricopeptide repeat domain of TRIP8b.	Asparagine	262-265	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	133-137
21411649-4	2011	We find that HCN1 and TRIP8b interact at two distinct sites: an upstream site where the C-linker/cyclic nucleotide-binding domain of HCN1 interacts with an 80 aa domain in the conserved central core of TRIP8b; and a downstream site where the C-terminal SNL (Ser-Asn-Leu) tripeptide of the channel interacts with the tetratricopeptide repeat domain of TRIP8b.	Asparagine	262-265	peroxisomal biogenesis factor 5-like	Mus musculus	202-208
21411649-4	2011	We find that HCN1 and TRIP8b interact at two distinct sites: an upstream site where the C-linker/cyclic nucleotide-binding domain of HCN1 interacts with an 80 aa domain in the conserved central core of TRIP8b; and a downstream site where the C-terminal SNL (Ser-Asn-Leu) tripeptide of the channel interacts with the tetratricopeptide repeat domain of TRIP8b.	Asparagine	262-265	peroxisomal biogenesis factor 5-like	Mus musculus	202-208
21205205-8	2011	Using electrophysiology, we found that an analogous mammalian AQP1 N76S mutant excluded protons and potassium ions, but leaked sodium ions, providing an argument for the overwhelming prevalence of Asn over other amino acids.	Asparagine	197-200	aquaporin 1 (Colton blood group)	Homo sapiens	62-66
21126579-10	2011	Western blot analysis confirmed increased mobility of OCTN2 transporters with progressive substitutions of asparagines 57, 64 and/or 91 with glutamine.	Asparagine	107-118	solute carrier family 22 member 5	Homo sapiens	54-59
20851096-2	2011	P450(cin) (CYP176A) has been found to be an exception to this paradigm, where the conserved threonine has been replaced with an asparagine.	Asparagine	128-138	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4
20851096-2	2011	P450(cin) (CYP176A) has been found to be an exception to this paradigm, where the conserved threonine has been replaced with an asparagine.	Asparagine	128-138	pyridoxal phosphatase	Homo sapiens	5-8
20851096-3	2011	Prior studies with a P450(cin) N242A mutant established that the Asn-242 was not a functional replacement for the conserved threonine but was essential for the regio- and stereocontrol of the oxidation of cineole.	Asparagine	65-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	21-25
20851096-3	2011	Prior studies with a P450(cin) N242A mutant established that the Asn-242 was not a functional replacement for the conserved threonine but was essential for the regio- and stereocontrol of the oxidation of cineole.	Asparagine	65-68	pyridoxal phosphatase	Homo sapiens	26-29
21282473-3	2011	This spontaneous post-translational modification, which might occur in aged proteins of the ECM, changes the length of the peptide bond and, in the case of asparagine, also of the charge.	Asparagine	156-166	multimerin 1	Homo sapiens	92-95
21165656-6	2011	RESULTS: We found the CBP/p300-interacting transactivator with glutamic acid/asparagine-rich carboxy-terminal domain 2 (CITED2) to be specifically upregulated in UC-associated cancer cell lines by BA treatment, at both mRNA and protein expression levels.	Asparagine	77-87	E1A binding protein p300	Homo sapiens	26-30
21165656-6	2011	RESULTS: We found the CBP/p300-interacting transactivator with glutamic acid/asparagine-rich carboxy-terminal domain 2 (CITED2) to be specifically upregulated in UC-associated cancer cell lines by BA treatment, at both mRNA and protein expression levels.	Asparagine	77-87	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	120-126
21271676-7	2011	Close examination of PGD2S spots revealed the presence of complex sialylated carbohydrates at residues Asn(78) and Asn(87) .	Asparagine	103-106	prostaglandin D2 synthase	Homo sapiens	21-26
21271676-7	2011	Close examination of PGD2S spots revealed the presence of complex sialylated carbohydrates at residues Asn(78) and Asn(87) .	Asparagine	115-118	prostaglandin D2 synthase	Homo sapiens	21-26
21146516-3	2011	Molecular analysis revealed that the mitf(fh53)ts results from a single base pair change producing an asparagine to tyrosine amino acid substitution in the DNA-binding domain, and the mitfa(vc7)ts allele is a mutation in a splice donor site that reduces the level of correctly-spliced transcripts.	Asparagine	102-112	melanocyte inducing transcription factor	Homo sapiens	37-41
21245954-7	2011	Considering the types of cataract, XPD-312 Asn/Asn genotype was found to be significantly different in patients with cortical (29%) type in comparison to controls (13.2%; p=0.03, OR=2.39, 95% CI=1.11-5.12).	Asparagine	43-46	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	35-38
21209017-6	2011	Asparagine, phenylalanine, and glutamine (10 mm) triggered GLP-1 release from primary cultures, but glutamine was the most efficacious, increasing secretion 1.9-fold with an EC(50) of 0.19 mm.	Asparagine	0-10	glucagon	Mus musculus	59-64
21074623-7	2011	We have designed and constructed another mutated cystatin C with the smallest possible structural intervention, that is a single-point mutation replacing hydrophobic V57 from the L1 loop by polar asparagine, known as a stabilizer of a beta-turn motif.	Asparagine	196-206	cystatin C	Homo sapiens	49-59
21078669-7	2011	Guided by structural bioinformatics including protein-protein docking, we revealed that the amino acids Arg(63), Lys(70), Lys(101), Glu(138), Asp(139), and Asn(160) engage in intermolecular salt bridges within the anxA5 trimer, which is the basic building block of the two-dimensional network.	Asparagine	156-159	annexin A5	Homo sapiens	214-219
21245954-7	2011	Considering the types of cataract, XPD-312 Asn/Asn genotype was found to be significantly different in patients with cortical (29%) type in comparison to controls (13.2%; p=0.03, OR=2.39, 95% CI=1.11-5.12).	Asparagine	47-50	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	35-38
21214909-6	2011	The final SNP (rs41694656) was located in the first exon of transcripts encoding the putative bovine neuroendocrine-specific protein NESP55, resulting in an aspartic acid-to-asparagine amino acid substitution at amino acid position 192.	Asparagine	174-184	GNAS complex locus	Bos taurus	133-139
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Asparagine	65-75	solute carrier family 38, member 3	Rattus norvegicus	26-31
20965538-3	2011	A second virus was generated using reverse genetics of the Del-E backbone to create Del-E-254 that contained an asparagine at amino acid 254.	Asparagine	112-122	DAP3 binding cell death enhancer 1	Homo sapiens	84-89
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Asparagine	65-75	solute carrier family 38, member 3	Rattus norvegicus	33-40
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Asparagine	65-75	carbonic anhydrase 2	Rattus norvegicus	219-240
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Asparagine	65-75	carbonic anhydrase 2	Rattus norvegicus	242-246
22187667-10	2011	SCN(-) ion also interacts directly with Asn-230 and through water molecules with Ser-235 and Phe-254.	Asparagine	40-43	sorcin	Homo sapiens	0-3
20695776-3	2011	During tissue development, repair, and regeneration of epithelial tissues, cells must interact with an interstitial fibronectin (Fn)-rich matrix, which has been shown to direct a more migratory/repair phenotype, presumably through interaction with Fn"s cell binding domain comprised of both synergy Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) sequences.	Asparagine	315-318	fibronectin 1	Homo sapiens	116-127
22132174-5	2011	One dwarf was compound heterozygous for the deletion and an insertion of an asparagine residue in the DNA-binding homeodomain of LHX3, suggesting involvement of the gene in the disorder.	Asparagine	76-86	LIM homeobox 3	Canis lupus familiaris	129-133
21135580-5	2011	Recent evidence also indicates that both TDP-43 and FUS contain prion-related domains rich in glutamine (Q) and asparagine (N) residues, and in the case of TDP-43 this is the location of most disease causing mutations.	Asparagine	112-122	TAR DNA binding protein	Homo sapiens	41-47
21135580-5	2011	Recent evidence also indicates that both TDP-43 and FUS contain prion-related domains rich in glutamine (Q) and asparagine (N) residues, and in the case of TDP-43 this is the location of most disease causing mutations.	Asparagine	112-122	FUS RNA binding protein	Homo sapiens	52-55
20135634-3	2011	The stabilization of active site residues Asn 303, Gly 324, Ser 329, Cys 331, Asp 364, and Tyr 411 through variable H-bonding coordination from the conserved water molecular center seems interesting in the uninhibited hydrated form of human IMPDH-II structures.	Asparagine	42-45	inosine monophosphate dehydrogenase 2	Homo sapiens	241-249
20974254-8	2011	SHBG levels tended to be higher among the subjects with the Asn/Asn (25.84+-3.6nmol/l) and S/S (24.50+-5.4nmol/l) genotypes compared to subjects with the Asp/Asn (24.38+-3.2nmol/l) and L/L (18.44+-4.2nmol/l) genotypes of the SHBG gene.	Asparagine	60-63	sex hormone binding globulin	Homo sapiens	0-4
20974254-8	2011	SHBG levels tended to be higher among the subjects with the Asn/Asn (25.84+-3.6nmol/l) and S/S (24.50+-5.4nmol/l) genotypes compared to subjects with the Asp/Asn (24.38+-3.2nmol/l) and L/L (18.44+-4.2nmol/l) genotypes of the SHBG gene.	Asparagine	64-67	sex hormone binding globulin	Homo sapiens	0-4
20974254-8	2011	SHBG levels tended to be higher among the subjects with the Asn/Asn (25.84+-3.6nmol/l) and S/S (24.50+-5.4nmol/l) genotypes compared to subjects with the Asp/Asn (24.38+-3.2nmol/l) and L/L (18.44+-4.2nmol/l) genotypes of the SHBG gene.	Asparagine	64-67	sex hormone binding globulin	Homo sapiens	0-4
21114375-1	2011	TRH-like peptides are characterized by substitution of basic amino acid histidine (related to authentic TRH) with neutral or acidic amino acid, like glutamic acid, phenylalanine, glutamine, tyrosine, leucin, valin, aspartic acid and asparagine.	Asparagine	233-243	thyrotropin releasing hormone	Homo sapiens	0-3
21106106-2	2010	Interestingly, the CRELD2 and asparagine-linked glycosylation 12 homolog (ALG12) genes are arranged as a bidirectional (head-to-head) gene pair and are separated by less than 400 bp.	Asparagine	30-40	asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase)	Mus musculus	74-79
20857097-4	2010	HLA-Cw group 1 (HLA-Cw alleles with asparagine at position 80), which serves as ligand for certain killer immunoglobulin-like receptors (KIR), was significantly overtransmitted in women with ICC (P = 0.04), and particularly in the subgroup of women infected with high risk HPV16 or 18 subtypes (P = 0.008).	Asparagine	36-46	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	137-140
20841510-3	2010	Both carried a homozygous missense mutation replacing a lysine with an asparagine residue at position 201 (K201N) of STAT1.	Asparagine	71-81	signal transducer and activator of transcription 1	Homo sapiens	117-122
22491306-7	2010	The modeled structure of CYP2C19 showed that the hydrogen bond between the main chain oxygen of Ile207 and the side chain Ogamma of Thr210 would be lost when Thr210 was substituted by Asn; however, no steric constraint was observed, although Asn is larger than Thr in size.	Asparagine	184-187	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	25-32
20470225-2	2010	As a step toward DNA vaccines, the goal of this work was to determine whether MUC1 peptides substituted with an asparagine at O-linked glycosylation sites, might expose MUC1 peptide backbone to serve as immunogens to generate cytotoxic T lymphocytes (CTL) from peripheral blood mononuclear cells of patients with ADCs.	Asparagine	112-122	mucin 1, cell surface associated	Homo sapiens	169-173
20470225-3	2010	Substitution of some or all tyrosine and serine residues by asparagine in MUC1 did not inhibit the generation of mucin-specific CTLs.	Asparagine	60-70	mucin 1, cell surface associated	Homo sapiens	74-78
20444205-4	2010	The free ammonium concentrations were also much higher in gln1-3/gln1-4, and Asn accumulation was higher in gln1-3 and gln1-3/gln1-4.	Asparagine	77-80	glutamine synthetase root isozyme 3	Zea mays	108-114
20444205-4	2010	The free ammonium concentrations were also much higher in gln1-3/gln1-4, and Asn accumulation was higher in gln1-3 and gln1-3/gln1-4.	Asparagine	77-80	glutamine synthetase root isozyme 3	Zea mays	108-114
20444205-4	2010	The free ammonium concentrations were also much higher in gln1-3/gln1-4, and Asn accumulation was higher in gln1-3 and gln1-3/gln1-4.	Asparagine	77-80	glutamine synthetase, chloroplastic	Zea mays	126-132
20670608-8	2010	This weaker binding may be attributed to interference of the Asn(169)N-glycan with the HCII heparin-binding site.	Asparagine	61-64	serpin family D member 1	Homo sapiens	87-91
20739279-5	2010	Through crystallographic analysis of SynCAM 2, we identified within the adhesive interface of its Ig1 domain an N-glycan on residue Asn(60).	Asparagine	132-135	cell adhesion molecule 2	Homo sapiens	37-45
20739279-6	2010	Structural modeling of the corresponding SynCAM 1 Ig1 domain indicates that its glycosylation sites Asn(70)/Asn(104) flank the binding interface of this domain.	Asparagine	100-103	cell adhesion molecule 1	Homo sapiens	41-49
20739279-6	2010	Structural modeling of the corresponding SynCAM 1 Ig1 domain indicates that its glycosylation sites Asn(70)/Asn(104) flank the binding interface of this domain.	Asparagine	108-111	cell adhesion molecule 1	Homo sapiens	41-49
20739279-9	2010	Although glycosylation of SynCAM 2 at Asn(60) reduces adhesion, N-glycans at Asn(70)/Asn(104) of SynCAM 1 increase its interactions.	Asparagine	38-41	cell adhesion molecule 2	Homo sapiens	26-34
20739279-9	2010	Although glycosylation of SynCAM 2 at Asn(60) reduces adhesion, N-glycans at Asn(70)/Asn(104) of SynCAM 1 increase its interactions.	Asparagine	77-80	cell adhesion molecule 1	Homo sapiens	97-105
20739279-9	2010	Although glycosylation of SynCAM 2 at Asn(60) reduces adhesion, N-glycans at Asn(70)/Asn(104) of SynCAM 1 increase its interactions.	Asparagine	77-80	cell adhesion molecule 1	Homo sapiens	97-105
20958962-8	2010	Ca2+ permeability could be rescued by mutating the NR3 N site glycine to the NR1-like asparagine.	Asparagine	86-96	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	51-54
20702624-3	2010	Here, we describe a virus with a rare mutation at position 179 in the V2 domain of gp120, where replacement of aspartic acid (D) by asparagine (N) converts a virus that is highly resistant to neutralization by multiple polyclonal and monoclonal antibodies, as well as antiviral entry inhibitors, to one that is sensitive to neutralization.	Asparagine	132-142	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	83-88
21072200-4	2010	Based on a genome-wide association study in Bos taurus, we found that ovulation rate is influenced by a variation in the N-terminal leucine/isoleucine/valine-binding protein (LIVBP) domain of GRIA1, in which serine is replaced by asparagine.	Asparagine	230-240	glutamate ionotropic receptor AMPA type subunit 1	Bos taurus	192-197
21072200-5	2010	GRIA1(Asn) has a weaker affinity to glutamate than GRIA1(Ser), both in Xenopus oocytes and in the membrane fraction of bovine brain.	Asparagine	6-9	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	0-5
20739628-11	2010	The inward-facing homology model of BCRP indicated that Thr(402) within transmembrane 1 may be important for helical interactions, and Asn(629) may be involved in BCRP-substrate interaction.	Asparagine	135-138	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	36-40
20739628-11	2010	The inward-facing homology model of BCRP indicated that Thr(402) within transmembrane 1 may be important for helical interactions, and Asn(629) may be involved in BCRP-substrate interaction.	Asparagine	135-138	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	163-167
20958962-8	2010	Ca2+ permeability could be rescued by mutating the NR3 N site glycine to the NR1-like asparagine.	Asparagine	86-96	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	77-80
20594154-7	2010	The data show that glutamic acid 248, asparagine 267 and, to a lesser extent, arginine 299 are important for the interaction between the MKP3 C-terminal and the N-terminal domains.	Asparagine	38-48	dual specificity phosphatase 6	Homo sapiens	137-141
20639197-2	2010	Based on consensus sequences, the GABA(A) receptor beta2 subunit contains three potential N-linked glycosylation sites, Asn-32, Asn-104, and Asn-173.	Asparagine	120-123	neuronal differentiation 1	Homo sapiens	51-56
20639197-2	2010	Based on consensus sequences, the GABA(A) receptor beta2 subunit contains three potential N-linked glycosylation sites, Asn-32, Asn-104, and Asn-173.	Asparagine	128-131	neuronal differentiation 1	Homo sapiens	51-56
20639197-2	2010	Based on consensus sequences, the GABA(A) receptor beta2 subunit contains three potential N-linked glycosylation sites, Asn-32, Asn-104, and Asn-173.	Asparagine	128-131	neuronal differentiation 1	Homo sapiens	51-56
20639197-6	2010	Although glycosylation of Asn-173 in the Cys-loop was important for stability of beta2 subunits when expressed alone, results obtained with flow cytometry, brefeldin A treatment, and endo-beta-N-acetylglucosaminidase H digestion suggested that glycosylation of Asn-104 was required for efficient alpha1beta2 receptor assembly and/or stability in the endoplasmic reticulum.	Asparagine	26-29	neuronal differentiation 1	Homo sapiens	81-86
20639197-6	2010	Although glycosylation of Asn-173 in the Cys-loop was important for stability of beta2 subunits when expressed alone, results obtained with flow cytometry, brefeldin A treatment, and endo-beta-N-acetylglucosaminidase H digestion suggested that glycosylation of Asn-104 was required for efficient alpha1beta2 receptor assembly and/or stability in the endoplasmic reticulum.	Asparagine	26-29	O-GlcNAcase	Homo sapiens	188-216
20639197-8	2010	In addition to functional heterogeneity, endo-beta-N-acetylglucosaminidase H digestion and glycomic profiling revealed that surface beta2 subunit N-glycans at Asn-173 were high mannose forms that were different from those of Asn-32 and N104.	Asparagine	159-162	neuronal differentiation 1	Homo sapiens	132-137
20639197-8	2010	In addition to functional heterogeneity, endo-beta-N-acetylglucosaminidase H digestion and glycomic profiling revealed that surface beta2 subunit N-glycans at Asn-173 were high mannose forms that were different from those of Asn-32 and N104.	Asparagine	225-228	neuronal differentiation 1	Homo sapiens	132-137
20615416-5	2010	Hbp is an autotransporter of the self-cleaving type, which cuts the polypeptide between two absolutely conserved asparagine residues buried within the barrel lumen.	Asparagine	113-123	heme binding protein 1	Homo sapiens	0-3
20923641-6	2010	We further characterized a mutation, Cx50N9R, where the Asn (N) at the ninth position of Cx50 was replaced by the corresponding Arg (R) at Cx36.	Asparagine	56-59	gap junction protein, alpha 8	Mus musculus	37-41
20923641-6	2010	We further characterized a mutation, Cx50N9R, where the Asn (N) at the ninth position of Cx50 was replaced by the corresponding Arg (R) at Cx36.	Asparagine	56-59	gap junction protein, delta 2	Mus musculus	139-143
20482929-0	2010	The casein peptide Asn-Pro-Trp-Asp-Gln enforces the intestinal tight junction partly by increasing occludin expression in Caco-2 cells.	Asparagine	19-22	occludin	Homo sapiens	99-107
20688526-1	2010	The formation of c(1) ions during collision-induced fragmentation of peptides with asparagine, ornithine, or glutamine at the N-terminal position 2 has been studied.	Asparagine	83-93	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	17-21
20931536-8	2010	RESULTS: Direct DNA sequence analysis identified a heterozygous 181G to A change in exon 3 of the PTPN11 gene in one patient, which resulted in the substitution of an aspartic acid residue by an asparagine at codon 61.	Asparagine	195-205	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	98-104
20949125-4	2010	An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner.	Asparagine	128-131	signal transducer and activator of transcription 1	Homo sapiens	14-19
20949125-4	2010	An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner.	Asparagine	128-131	signal transducer and activator of transcription 1	Homo sapiens	106-111
20949125-4	2010	An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner.	Asparagine	128-131	interferon gamma	Homo sapiens	225-234
20573782-4	2010	Our results suggest that this network involves the cluster of residues Arg(188) in TM2, Gln(380) in TM7, and Asn(229) in TM3.	Asparagine	109-112	tropomyosin 3	Homo sapiens	121-124
21305874-1	2010	L-asparaginase catalyzes the hydrolysis of L-asparagine into aspartate and ammonia, which is used as an anti-neoplastic agent.	Asparagine	43-55	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
20573835-0	2010	A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms.	Asparagine	9-19	mannose binding lectin 2	Homo sapiens	144-166
21092465-2	2010	METHODS: a total of 226 amino acid residues of FVIII B domain with six potential asparagines-linked glycosylation sites (N6) were incorporated into heavy chain of BDD-FVIII.	Asparagine	81-92	coagulation factor VIII	Homo sapiens	47-52
21092465-2	2010	METHODS: a total of 226 amino acid residues of FVIII B domain with six potential asparagines-linked glycosylation sites (N6) were incorporated into heavy chain of BDD-FVIII.	Asparagine	81-92	coagulation factor VIII	Homo sapiens	163-172
20566625-0	2010	Asparagine of z8 insert is critical for the affinity, conformation, and acetylcholine receptor-clustering activity of neural agrin.	Asparagine	0-10	agrin	Homo sapiens	125-130
20713507-2	2010	Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage.	Asparagine	175-185	tudor	Drosophila melanogaster	36-41
20713507-2	2010	Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage.	Asparagine	175-185	tudor	Drosophila melanogaster	70-75
19824051-6	2010	Focused structure-activity studies performed on Phe(2), Arg(3), and Asn(4) confirmed this indication and revealed the chemical requirements of these positions for NPSR binding and activation.	Asparagine	68-71	neuropeptide S receptor 1	Homo sapiens	163-167
20403965-9	2010	This study supports the origin of ENAM earlier in vertebrate evolution, confirms that tooth loss in modern birds led to the invalidation of enamel genes, and adds information on the important role played by, for example, the phosphorylated serines and the glycosylated asparagines for correct ENAM functions.	Asparagine	269-280	enamelin	Homo sapiens	34-38
20677779-3	2010	Though other causes may exist, an autosomal dominant mutation that alters codon 241 of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene from encoding an asparagine to encoding a serine gives rise to the symptoms of the disease.	Asparagine	156-166	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	128-132
20561531-4	2010	Mutation of each of the three Asn residues in Par-4 abrogated binding to all three SPSB proteins, while changing EL to DI enhanced binding.	Asparagine	30-33	Prader Willi/Angelman region RNA 4	Homo sapiens	46-51
20677779-0	2010	Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria.	Asparagine	55-58	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	77-112
20677779-3	2010	Though other causes may exist, an autosomal dominant mutation that alters codon 241 of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene from encoding an asparagine to encoding a serine gives rise to the symptoms of the disease.	Asparagine	156-166	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	91-126
20554523-4	2010	Furthermore, we found that binding to polyglutamine aggregates requires a previously uncharacterized glutamine/asparagine (Q/N)-rich region in the C-terminal domain of TDP-43.	Asparagine	111-121	TAR DNA binding protein	Homo sapiens	168-174
20525688-1	2010	We previously identified Asn(331) in transmembrane segment 7 (TM7) as a key residue determining substrate affinity in Hxt2, a moderately high-affinity facilitative glucose transporter of Saccharomyces cerevisiae.	Asparagine	25-28	hexose transporter HXT2	Saccharomyces cerevisiae S288C	118-122
20525688-3	2010	The functional role of Asp(340) in Hxt7, the residue corresponding to Asn(331) of Hxt2, was examined by replacing it with each of the other 19 amino acids.	Asparagine	70-73	hexose transporter HXT7	Saccharomyces cerevisiae S288C	35-39
20622883-5	2010	A conserved asparagine (N)-linked glycosylation site at position 46 (N46) in the first conserved domain of muHC was absolutely required for pre-BCR function, and swapping that domain with deltaHC resulted in a functional deltaHC-containing pre-BCR.	Asparagine	12-22	BCR activator of RhoGEF and GTPase	Homo sapiens	144-147
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Asparagine	183-193	ubiquitin specific peptidase 44	Mus musculus	36-41
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Asparagine	183-193	ubiquitin specific peptidase 44	Mus musculus	43-73
20622883-5	2010	A conserved asparagine (N)-linked glycosylation site at position 46 (N46) in the first conserved domain of muHC was absolutely required for pre-BCR function, and swapping that domain with deltaHC resulted in a functional deltaHC-containing pre-BCR.	Asparagine	12-22	BCR activator of RhoGEF and GTPase	Homo sapiens	244-247
20484158-9	2010	In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals.	Asparagine	50-53	troponin I1, slow skeletal type	Homo sapiens	68-73
20484158-9	2010	In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals.	Asparagine	50-53	troponin I3, cardiac type	Homo sapiens	186-190
20444482-2	2010	In HLA-B*57/5801-negative subjects infected with 242N escape variant, reversion to Asn appeared at median (IQR) 103 days (97-213 days) post-seroconversion (p/s) and became dominant at 193 days (170-215 days) p/s.	Asparagine	83-86	major histocompatibility complex, class I, B	Homo sapiens	3-8
20463099-7	2010	RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His).	Asparagine	113-123	glial cells missing transcription factor 2	Homo sapiens	79-83
20463099-7	2010	RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His).	Asparagine	125-128	glial cells missing transcription factor 2	Homo sapiens	79-83
20637156-0	2010	[Relationship between the antileukemic activity of L-asparaginase and Asn level around leukemic cells].	Asparagine	70-73	asparaginase and isoaspartyl peptidase 1	Homo sapiens	51-65
20637156-1	2010	OBJECTIVE: To study the antileukemic activity of L-asparaginase through determining the changes of 4 kinds of amino acids (Asn, Aspa, Glu and Gln) in cell culture medium.	Asparagine	123-126	asparaginase and isoaspartyl peptidase 1	Homo sapiens	49-63
20202874-7	2010	This change results in a substitution of aspartic acid to asparagine in a highly conserved domain of the ND3 subunit.	Asparagine	58-68	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	105-108
20424163-4	2010	4E-BP2 undergoes asparagine deamidation, solely in the brain, during early postnatal development.	Asparagine	17-27	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	0-6
20424163-10	2010	Using an antibody that recognizes 4E-BP2, which harbors isoaspartates at the deamidation sites, Asn(99) and Asn(102), we demonstrate that 4E-BP2 in PIMT-/- brain lysates contains isoaspartate residues.	Asparagine	96-99	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	34-40
20424163-10	2010	Using an antibody that recognizes 4E-BP2, which harbors isoaspartates at the deamidation sites, Asn(99) and Asn(102), we demonstrate that 4E-BP2 in PIMT-/- brain lysates contains isoaspartate residues.	Asparagine	96-99	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	148-152
20424163-10	2010	Using an antibody that recognizes 4E-BP2, which harbors isoaspartates at the deamidation sites, Asn(99) and Asn(102), we demonstrate that 4E-BP2 in PIMT-/- brain lysates contains isoaspartate residues.	Asparagine	108-111	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	34-40
20424163-10	2010	Using an antibody that recognizes 4E-BP2, which harbors isoaspartates at the deamidation sites, Asn(99) and Asn(102), we demonstrate that 4E-BP2 in PIMT-/- brain lysates contains isoaspartate residues.	Asparagine	108-111	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	148-152
20473272-3	2010	Knockdown of ATF4 significantly reduced the levels of asparagine synthetase (ASNS) and overexpression of ASNS or supplementation of asparagine in trans, reversed the proliferation block and increased survival in ATF4 knockdown cells.	Asparagine	54-64	activating transcription factor 4	Homo sapiens	13-17
20642010-0	2004	Cy5-labeled aza-peptidyl Pro-Asn epoxide Legumain or asparaginyl endopeptidase is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine and, occasionally, aspartic acid residues (1-3).	Asparagine	170-180	legumain	Homo sapiens	53-78
20387063-2	2010	This allele carries a coding polymorphism in the first epidermal growth factor-like domain of CD93, which results in an amino acid substitution from Asn--&gt;His at position 264.	Asparagine	149-152	CD93 antigen	Mus musculus	94-98
20207824-0	2010	Importance of asparagine residues at positions 13 and 26 on the amino-terminal domain of human somatostatin receptor subtype-5 in signalling.	Asparagine	14-24	somatostatin receptor 5	Homo sapiens	95-126
20207824-6	2010	These results clearly show the importance of these asparagine residues in the agonist-specific signalling of hSSTR5, although it was not enough to identify the consequence of oligosaccharides.	Asparagine	51-61	somatostatin receptor 5	Homo sapiens	109-115
20374902-2	2010	A missense mutation G/A in position 1426, which causes Asp-Asn substitution at position 298 in the MC4R gene has been associated with feed intake, fatness and growth, however published results of its effect are inconsistent.	Asparagine	59-62	melanocortin 4 receptor	Sus scrofa	99-103
20307995-2	2010	This mutation results from the substitution of asparagine (AAC) by lysine (AAA) at codon 103 of a non-mature (signal peptide-containing) leptin and corresponds to the N82K mutation in the mature protein.	Asparagine	47-57	glycine-N-acyltransferase	Homo sapiens	59-62
20307995-2	2010	This mutation results from the substitution of asparagine (AAC) by lysine (AAA) at codon 103 of a non-mature (signal peptide-containing) leptin and corresponds to the N82K mutation in the mature protein.	Asparagine	47-57	leptin	Homo sapiens	137-143
20416277-2	2010	Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the hydroxylation of the specific proline and asparagine residues of HIF-1alpha, thereby controlling the level of HIF-1alpha and ultimately the HIF response.	Asparagine	203-213	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
20143318-6	2010	Substrate channeling between the enzymes was observed when NSE with its active regions Leu(11)-Asn(16), Arg(49)-Lys(59), and Gly(155)-Ala(158) covered the Ser(14)-Leu(30) loop of dPGM-B.	Asparagine	95-98	enolase 2	Homo sapiens	59-62
20561401-6	2010	It is concluded that the AsnS plays a critical role in regulating cellular biological behavior after depletion of asparagine, the AsnS mRNA expression level in cells reflects the sensitivity of cells to L-Asp.	Asparagine	114-124	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	25-29
20146544-8	2010	Interestingly, in the HSP70 homologue the GlcNAc modification is attached to an asparagine residue of a N-glycosylation motif.	Asparagine	80-90	Heat-shock-protein-70Ab	Drosophila melanogaster	22-27
19931409-4	2010	At normoxia a continuous hydroxylation of HIF1alpha prolines by prolyl hydroxylase domain enzymes (PHDs) and asparagines by factor-inhibiting HIF (FIH) occurs, resulting in HIF1alpha polyubiquitination/degradation.	Asparagine	109-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-182
20022356-7	2010	RESULTS: Sequence analysis of the FXII gene revealed a G--&gt;C point mutation at nucleotide 9845, resulting in Lys346 (AAG)--&gt;Asn (AAC) replacement in the catalytic domain.	Asparagine	130-133	glycine-N-acyltransferase	Homo sapiens	135-138
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Asparagine	288-291	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	102-106
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Asparagine	288-291	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	115-119
19818407-1	2010	Bovine CD38, a type II glycoprotein, contains two potential N-glycosylation sites (Asn-201 and Asn-268) in its extracellular domain.	Asparagine	83-86	CD38 molecule	Bos taurus	7-11
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Asparagine	107-110	glycolipid transfer protein	Homo sapiens	37-41
19887450-5	2010	In addition, we identify six essential residues Tyr-87, Ile-97, Arg-99, Asn-103, Lys-105, and Lys-108 that define a compact HA-binding surface on Lyve-1, encompassing the epitope for an adhesion-blocking monoclonal antibody 3A, in an analogous position to the HA-binding surface in CD44.	Asparagine	72-75	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	146-152
20190138-7	2010	Analysis of the beta(2) cytoplasmic tail showed that the sequence Asn(727)-Ser(734) is important in alpha(M)beta(2)-induced PKCdelta Tyr(311) phosphorylation.	Asparagine	66-69	protein kinase C delta	Homo sapiens	124-132
19818407-1	2010	Bovine CD38, a type II glycoprotein, contains two potential N-glycosylation sites (Asn-201 and Asn-268) in its extracellular domain.	Asparagine	95-98	CD38 molecule	Bos taurus	7-11
20347422-3	2010	Here we describe asparagine deamidation as a brain-specific posttranslational modification of 4E-BP2.	Asparagine	17-27	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	94-100
20113314-8	2010	Substituting the histidine residue at position 3 in human hepcidin-25 and comparably the asparagine residue at position 3 in murine hepcidin-25 with an alanine residue markedly diminished the affinity for copper.	Asparagine	89-99	hepcidin antimicrobial peptide	Mus musculus	132-140
20347422-5	2010	Two deamidation sites were mapped to an asparagine-rich sequence unique to 4E-BP2.	Asparagine	40-50	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	75-81
20224794-1	2010	The glutamine/asparagine (Q/N)-rich yeast prion protein Sup35 has a low intrinsic propensity to spontaneously self-assemble into ordered, beta-sheet-rich amyloid fibrils.	Asparagine	14-24	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	56-61
20192263-9	2010	The solution structure of Cu(I)-CopK demonstrates that Cu(I) binding induces a complete structural modification with the disruption of the second beta-sheet and a rotation of the C-terminal part of nearly 180 degrees around a hinge formed by asparagine 57.	Asparagine	242-252	hypothetical protein	Cupriavidus metallidurans CH34	32-36
20106972-0	2010	Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners.	Asparagine	99-102	epidermal growth factor receptor pathway substrate 15	Homo sapiens	54-59
20212335-8	2010	RESULTS: Baseline of the allele prevalence of the mdr1 86 locus in the AS+ AQ was successful for 80 isolates: 71(8.11%) carried parasites harbouring the mdr1-86 Tyr resistance allele, while 7 (89.19%) carried mdr1-86 Asn sensitivity allele and 2 (2.7%) were of mixed infection, having both resistance and wild type allele.	Asparagine	217-220	ATP binding cassette subfamily B member 1	Homo sapiens	50-54
20199682-6	2010	CONCLUSIONS: The results presented here demonstrate that an intrinsically unstructured, and asparagine-rich, region of a MHCK-B can mediate specific targeting of the kinase to phosphorylate myosin II heavy chain.	Asparagine	92-102	myosin heavy chain 14	Homo sapiens	190-196
20092352-10	2010	Glycan preference was mapped to binding site 2, since reciprocal mutation of a single amino acid (asparagine 32 of Stx1 B-subunit/serine 31 of Stx2 B-subunit) reversed binding preference.	Asparagine	98-108	syntaxin 1A	Homo sapiens	115-119
20007322-1	2010	Oligosaccharyltransferase (OST) catalyzes the transfer of an oligosaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains.	Asparagine	102-112	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
20030628-5	2010	Together, these results suggested that a positively charged EF1A loop binds to a negatively charged conserved groove on the LpGT structure, and that two asparagine residues are essential for catalysis.	Asparagine	153-163	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	60-64
20230086-7	2010	A gene x experience interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele maintained greater positive affect despite elevations in daily pain than those homozygous for the asn allele.	Asparagine	211-214	opioid receptor mu 1	Homo sapiens	36-41
19850839-5	2010	Synthetic PEDF peptides 34-mer (Asp(44)-Asn(77)) and 44-mer (Val(78)-Thr(121)) were used.	Asparagine	40-43	serpin family F member 1	Homo sapiens	10-14
19925050-1	2010	Bone marrow mesenchymal stromal cells (MSCs) can rescue acute lymphoblastic leukemia (ALL) cells from L-asparaginase by replenishing the depleted asparagine.	Asparagine	146-156	asparaginase and isoaspartyl peptidase 1	Homo sapiens	102-116
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	70-73	furin, paired basic amino acid cleaving enzyme	Homo sapiens	41-46
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	70-73	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	70-73	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	83-86	furin, paired basic amino acid cleaving enzyme	Homo sapiens	41-46
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	83-86	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
19909832-11	2010	Indeed, site-directed mutagenesis of two furin N-glycosylation sites, Asn(387) and Asn(440), abrogated furin activation and this mutant was unable to rescue ADAMTS5 processing in furin-deficient cells.	Asparagine	83-86	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
20007322-1	2010	Oligosaccharyltransferase (OST) catalyzes the transfer of an oligosaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains.	Asparagine	102-112	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
20022931-0	2010	Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells.	Asparagine	8-18	melanocortin 2 receptor	Homo sapiens	93-121
19940136-4	2010	Mutation of two conserved residues (Asn-110 and Tyr-145) located in the XPA-binding site of ERCC1 dramatically affected NER but not nuclease activity on model DNA substrates.	Asparagine	36-39	XPA, DNA damage recognition and repair factor	Homo sapiens	72-75
19940136-4	2010	Mutation of two conserved residues (Asn-110 and Tyr-145) located in the XPA-binding site of ERCC1 dramatically affected NER but not nuclease activity on model DNA substrates.	Asparagine	36-39	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	92-97
19853576-4	2010	Three complexes, namely Lhca2, Lhca4 and Lhca9, exhibit emission maxima above 707 nm and all carry an asparagine as ligand for Chl 603.	Asparagine	102-112	uncharacterized protein	Chlamydomonas reinhardtii	24-29
19853576-4	2010	Three complexes, namely Lhca2, Lhca4 and Lhca9, exhibit emission maxima above 707 nm and all carry an asparagine as ligand for Chl 603.	Asparagine	102-112	uncharacterized protein	Chlamydomonas reinhardtii	31-36
19853576-4	2010	Three complexes, namely Lhca2, Lhca4 and Lhca9, exhibit emission maxima above 707 nm and all carry an asparagine as ligand for Chl 603.	Asparagine	102-112	uncharacterized protein	Chlamydomonas reinhardtii	41-46
20022931-0	2010	Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells.	Asparagine	8-18	melanocortin 2 receptor	Homo sapiens	123-146
20022931-4	2010	Western blot analyses performed with or without endoglycosidase H, peptide:N-glycosidase F or tunicamycin treatments and site-directed mutagenesis revealed that MC2R was glycosylated in the N-terminal domain at its two putative N-glycosylation sites (Asn(12)-Asn(13)-Thr(14) and Asn(17)-Asn(18)-Ser(19)).	Asparagine	251-254	melanocortin 2 receptor	Homo sapiens	161-165
20022931-4	2010	Western blot analyses performed with or without endoglycosidase H, peptide:N-glycosidase F or tunicamycin treatments and site-directed mutagenesis revealed that MC2R was glycosylated in the N-terminal domain at its two putative N-glycosylation sites (Asn(12)-Asn(13)-Thr(14) and Asn(17)-Asn(18)-Ser(19)).	Asparagine	259-262	melanocortin 2 receptor	Homo sapiens	161-165
20022931-4	2010	Western blot analyses performed with or without endoglycosidase H, peptide:N-glycosidase F or tunicamycin treatments and site-directed mutagenesis revealed that MC2R was glycosylated in the N-terminal domain at its two putative N-glycosylation sites (Asn(12)-Asn(13)-Thr(14) and Asn(17)-Asn(18)-Ser(19)).	Asparagine	259-262	melanocortin 2 receptor	Homo sapiens	161-165
20022931-4	2010	Western blot analyses performed with or without endoglycosidase H, peptide:N-glycosidase F or tunicamycin treatments and site-directed mutagenesis revealed that MC2R was glycosylated in the N-terminal domain at its two putative N-glycosylation sites (Asn(12)-Asn(13)-Thr(14) and Asn(17)-Asn(18)-Ser(19)).	Asparagine	259-262	melanocortin 2 receptor	Homo sapiens	161-165
19915009-4	2010	We have mutated the asparagines of all nine functional N-glycosylation sites of gp130 to glutamine and systematically analyzed the consequences of deleted N-glycosylation (dNG) in both cellular gp130 and in a soluble gp130-IgG1-Fc fusion protein (sgp130Fc).	Asparagine	20-31	interleukin 6 cytokine family signal transducer	Homo sapiens	80-85
19592704-5	2010	All of the putative N-linked glycosylation sites (Asn(270), Asn(367), and Asn(389)) of NCEH are glycosylated.	Asparagine	50-53	neutral cholesterol ester hydrolase 1	Homo sapiens	87-91
19592704-5	2010	All of the putative N-linked glycosylation sites (Asn(270), Asn(367), and Asn(389)) of NCEH are glycosylated.	Asparagine	60-63	neutral cholesterol ester hydrolase 1	Homo sapiens	87-91
19592704-5	2010	All of the putative N-linked glycosylation sites (Asn(270), Asn(367), and Asn(389)) of NCEH are glycosylated.	Asparagine	60-63	neutral cholesterol ester hydrolase 1	Homo sapiens	87-91
19793597-8	2010	The other was a novel missense mutation resulting in a substitution of Asn (AAC) for His (CAC) at codon 373 in exon 6 (H373N) on a paternal allele.	Asparagine	71-74	glycine-N-acyltransferase	Homo sapiens	76-79
19760636-7	2010	Individuals with the XPD 312 Asn/Asn genotype had an 8.6-fold increase in risk (OR = 8.59; 95% CI = 1.81-40.66).	Asparagine	29-32	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	21-24
19760636-7	2010	Individuals with the XPD 312 Asn/Asn genotype had an 8.6-fold increase in risk (OR = 8.59; 95% CI = 1.81-40.66).	Asparagine	33-36	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	21-24
19935792-4	2010	CCBE1 contains collagen repeats and an aspartic acid/asparagine hydroxylation/EGF-like domain, suggesting a function in extracellular matrix remodelling and migration, which was determined using small-interfering RNA (siRNA)-mediated knockdown and over-expression of CCBE1 in cell lines.	Asparagine	53-63	collagen and calcium binding EGF domains 1	Homo sapiens	0-5
20672054-0	2010	Asn and asn: critical residues for in vitro biological activity of reteplase.	Asparagine	0-3	plasminogen activator, tissue type	Homo sapiens	67-76
20672054-0	2010	Asn and asn: critical residues for in vitro biological activity of reteplase.	Asparagine	8-11	plasminogen activator, tissue type	Homo sapiens	67-76
19828451-4	2009	Complex formation of BD1 with a histone H3 tail polypeptide encompassing residues 12-19 showed binding of the Nzeta-acetylated lysine 14 to the conserved asparagine 140 of Brd4.	Asparagine	154-164	defensin beta 1	Homo sapiens	21-24
19800422-0	2010	The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation.	Asparagine	12-22	ST14 transmembrane serine protease matriptase	Rattus norvegicus	76-86
19800422-1	2010	Matriptase is a type II transmembrane serine protease containing one potential site for asparagine-linked glycosylation (N-glycosylation) on the catalytic domain (Asn772).	Asparagine	88-98	ST14 transmembrane serine protease matriptase	Rattus norvegicus	0-10
19903818-13	2010	Taken together, our data showed that an asparagine at position 255 in Kv1.1 is required for normal voltage dependence and kinetics of channel gating.	Asparagine	40-50	potassium voltage-gated channel subfamily A member 1	Homo sapiens	70-75
21077763-0	2010	Hb East Timor [beta80(EF4)Asn His, AAC&gt;CAC (HBB c.241A&gt;C)], a variant hemoglobin associated with normal hematology.	Asparagine	26-29	GTP binding elongation factor GUF1	Homo sapiens	22-25
21077763-3	2010	The variant is due to a missense mutation at amino acid codon 80 (AAC&gt;CAC) which results in the substitution of histidine for asparagine.	Asparagine	129-139	carbonic anhydrase 2	Homo sapiens	73-76
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Asparagine	132-135	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Asparagine	155-158	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
19899825-5	2010	Additionally, we characterized alterations in the glycan structures of vitronectin (Asn-169, 242) and antithrombin III (Asn-225) that were identified in HCC patient plasma.	Asparagine	84-87	vitronectin	Homo sapiens	71-82
19899825-5	2010	Additionally, we characterized alterations in the glycan structures of vitronectin (Asn-169, 242) and antithrombin III (Asn-225) that were identified in HCC patient plasma.	Asparagine	120-123	serpin family C member 1	Homo sapiens	102-118
19880517-5	2009	Thus, Asn(140) does not contribute substantially to substrate binding but is essential for the chemical step, where it stabilizes the transition state by approximately 6 kcal/mol (compared with 11.6 kcal/mol stabilization provided by TDG overall).	Asparagine	6-9	thymine DNA glycosylase	Homo sapiens	234-237
19828451-4	2009	Complex formation of BD1 with a histone H3 tail polypeptide encompassing residues 12-19 showed binding of the Nzeta-acetylated lysine 14 to the conserved asparagine 140 of Brd4.	Asparagine	154-164	bromodomain containing 4	Homo sapiens	172-176
20560553-2	2009	Fibronectin is a predominant ECM protein that engages integrin cell receptors through its Arg-Gly-Asp (RGD) and Pro-His-Ser-Arg-Asn (PHSRN) peptide binding sites.	Asparagine	128-131	fibronectin 1	Homo sapiens	0-11
19766654-6	2009	In fact, substitution of this Asn to Ala of CHC diminished its ability to interact with p53, leading to reduced activity to transactivate p53.	Asparagine	30-33	tumor protein p53	Homo sapiens	138-141
19926848-3	2009	Binding of 3 selective ligands (GC-1, KB141, and GC-24) is characterized at the atomic level; preferential binding depends on a nonconserved residue (Asn-331beta) in the TRbeta ligand-binding cavity (LBC), and GC-24 gains extra selectivity from insertion of a bulky side group into an extension of the LBC that only opens up with this ligand.	Asparagine	150-153	T cell receptor beta locus	Homo sapiens	170-176
19766174-2	2009	The ALAD is controlled by two codominant alleles (ALAD1 and ALAD2), which result in a Asn-Lys substitution at amino acid position 59 of the mature enzyme based on a single nucleotide polymorphism (SNP) (G177C) leading three phenotypes (ALAD1-1, ALAD1-2, and ALAD2-2).	Asparagine	86-89	aminolevulinate dehydratase	Homo sapiens	4-8
19766654-6	2009	In fact, substitution of this Asn to Ala of CHC diminished its ability to interact with p53, leading to reduced activity to transactivate p53.	Asparagine	30-33	clathrin heavy chain	Homo sapiens	44-47
19864458-6	2009	MICAL-L1 is a largely uncharacterized member of the MICAL-family of proteins that uniquely contains two asparagine-proline-phenylalanine motifs, sequences that typically interact with EH-domains.	Asparagine	104-114	MICAL like 1	Homo sapiens	0-8
19766654-6	2009	In fact, substitution of this Asn to Ala of CHC diminished its ability to interact with p53, leading to reduced activity to transactivate p53.	Asparagine	30-33	tumor protein p53	Homo sapiens	88-91
19665052-3	2009	The SNP 1181 is a novel SNP, corresponding to a non-conservative substitution (AGT/AAT) that could be the cause of amino acid substitution ((364)Serine/(364)Asparagine).	Asparagine	157-167	angiotensinogen	Bos taurus	79-82
20046085-2	2009	This variant arises from a Lys --&gt; Asn substitution due to a mutation of AAA to AAC or AAT at codon 133 of the beta-globin gene.	Asparagine	38-41	glycine-N-acyltransferase	Homo sapiens	83-86
20046085-2	2009	This variant arises from a Lys --&gt; Asn substitution due to a mutation of AAA to AAC or AAT at codon 133 of the beta-globin gene.	Asparagine	38-41	serpin family A member 1	Homo sapiens	90-93
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Asparagine	310-313	fibronectin 1a	Danio rerio	50-63
20011099-6	2009	This patient harbors an isoleucine to asparagine mutation (I304N) in the second FMRP KH-type RNA-binding domain, however, this single case report was complicated because the patient harbored a superimposed familial liver disease.	Asparagine	38-48	fragile X messenger ribonucleoprotein 1	Homo sapiens	80-84
19778320-1	2009	The complete genomic sequence of HLA-B*1325 allele shows one nucleotide difference from B*130101 at nt 302 where A --&gt; G resulting in an amino acid substitution from Asn(AAC) to Ser(AGC) at codon 77 in exon 2.	Asparagine	169-172	major histocompatibility complex, class I, B	Homo sapiens	33-38
19778320-1	2009	The complete genomic sequence of HLA-B*1325 allele shows one nucleotide difference from B*130101 at nt 302 where A --&gt; G resulting in an amino acid substitution from Asn(AAC) to Ser(AGC) at codon 77 in exon 2.	Asparagine	169-172	glycine-N-acyltransferase	Homo sapiens	173-176
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Asparagine	310-313	fibronectin 1a	Danio rerio	50-61
19706343-2	2009	beta2GPI is N-glycosylated at several asparagine residues and the glycan moiety conjugated to residue 143 has been proposed to interact with the Gly40-Arg43 motif of beta2GPI.	Asparagine	38-48	apolipoprotein H	Homo sapiens	0-8
19758985-3	2009	In vitro, an 18-amino acid segment, residues 595-612, immediately upstream of the C-terminal endoplasmic reticulum targeting sequence is required for N-glycosylation of Asn(594), which permits COX-2 protein to enter the endoplasmic reticulum-associated protein degradation system.	Asparagine	169-172	cytochrome c oxidase II, mitochondrial	Mus musculus	193-198
19706343-4	2009	We hypothesized that the structure or composition of the glycan at Asn-143 might be associated with the APS symptom by shielding or exposing the Gly40-Arg43 motif towards the anti-beta2GPI autoantibody.	Asparagine	67-70	apolipoprotein H	Homo sapiens	180-188
19706343-9	2009	These data indicate that some APS patients have beta2GPI molecules with a reduced number of negatively charged sialic acid units in the glycan structure at Asn-143.	Asparagine	156-159	apolipoprotein H	Homo sapiens	48-56
19690161-0	2009	Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation.	Asparagine	28-31	interleukin 6	Homo sapiens	74-87
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	17-40
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	42-47
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	E1A binding protein p300	Homo sapiens	116-120
19726677-2	2009	During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue.	Asparagine	149-152	CREB binding protein	Homo sapiens	121-124
19595785-2	2009	In the current study, a novel G/A polymorphism in exon 3 of the chicken FABP4 gene was identified associated with different chicken breeds that leads to either Ser or Asn at amino acid 89 of the AFABP protein.	Asparagine	167-170	fatty acid binding protein 4	Gallus gallus	72-77
19595785-2	2009	In the current study, a novel G/A polymorphism in exon 3 of the chicken FABP4 gene was identified associated with different chicken breeds that leads to either Ser or Asn at amino acid 89 of the AFABP protein.	Asparagine	167-170	fatty acid binding protein 4	Gallus gallus	195-200
20023241-4	2009	A single nucleotide polymorphism K167N (G501C) of the LOX-1 gene results in an amino acid dimorphism (Lys/Asn) at residue 167.	Asparagine	106-109	oxidized low density lipoprotein receptor 1	Homo sapiens	54-59
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	102-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	102-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	102-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	102-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	114-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	114-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	114-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Asparagine	114-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19690161-9	2009	We tested the hypothesis that the Asn-89 complex glycan of vIL-6 alone was sufficient to confer binding to gp130 independently of IL-6Ralpha.	Asparagine	34-37	interleukin 6 cytokine family signal transducer	Homo sapiens	107-112
19690161-11	2009	Our findings support the conclusion that complex glycans on Asn-89 of vIL-6 specifically promote a protein conformation that allows the viral cytokine to bind gp130 independently of IL-6Ralpha.	Asparagine	60-63	interleukin 6 cytokine family signal transducer	Homo sapiens	159-164
19782077-5	2009	The K60 of Nedd8 was not present at the E2-binding surface, but its mutation to Asn converted Nedd8 into a ubiquitin-acceptor.	Asparagine	80-83	NEDD8 ubiquitin like modifier	Homo sapiens	11-16
19782077-5	2009	The K60 of Nedd8 was not present at the E2-binding surface, but its mutation to Asn converted Nedd8 into a ubiquitin-acceptor.	Asparagine	80-83	NEDD8 ubiquitin like modifier	Homo sapiens	94-99
19741491-2	2009	Mutations at beta residue 265 (Ser in beta1; Asn in beta2 or beta3) profoundly affect etomidate sensitivity.	Asparagine	45-48	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	52-57
19684018-2	2009	The extracellular 65-amino acid amino terminus of hCTR1 contains both N-linked (at Asn(15)) and O-linked (at Thr(27)) sites of glycosylation.	Asparagine	83-86	solute carrier family 31 member 1	Homo sapiens	50-55
19805097-5	2009	In the Salmonella TAA, SadA, the core asparagines form rings of interacting residues with the following threonines, grouped around a central anion.	Asparagine	38-49	BR serine/threonine kinase 2	Homo sapiens	23-27
19608689-3	2009	A clustering of familial cases with the MPL-G1073A mutation that results in a serine to asparagine substitution (S505N) has been recently reported in Italy.	Asparagine	88-98	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	40-43
19608745-2	2009	The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and the protonation status of the proximal histidine.	Asparagine	163-173	myeloperoxidase	Homo sapiens	52-67
19786583-8	2009	The decrease of channel conductance by extracellular protons was mimicked by mutation of the outer pore histidine in K(Ca)2.2 to an asparagine residue.	Asparagine	132-142	potassium calcium-activated channel subfamily N member 2	Homo sapiens	117-125
19608745-2	2009	The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and the protonation status of the proximal histidine.	Asparagine	163-173	myeloperoxidase	Homo sapiens	69-72
19936267-5	2009	In the course of this study, an L-asparagine derivative was condensed with benzaldehyde and subsequently converted to orthogonally protected (R)-beta(2)-homoaspartate.	Asparagine	32-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	145-151
19481602-8	2009	Deamination of Asn at position 24 might be responsible for degradation of VIP derivative, and stability and chemical modification studies led us to the successful development of novel VIP derivatives with higher stability and biological functions.	Asparagine	15-18	vasoactive intestinal peptide	Rattus norvegicus	74-77
19555656-4	2009	A novel heteroplasmic A14841G mutation, one of the variants with a serine substituted for a highly conserved asparagine at amino acid 32 of Cytochrome b (Cytb), may play a synergistic role with the C4171A mutation, leading to significantly different clinical manifestations of LHON among these families.	Asparagine	109-119	mitochondrially encoded cytochrome b	Homo sapiens	140-152
19555656-4	2009	A novel heteroplasmic A14841G mutation, one of the variants with a serine substituted for a highly conserved asparagine at amino acid 32 of Cytochrome b (Cytb), may play a synergistic role with the C4171A mutation, leading to significantly different clinical manifestations of LHON among these families.	Asparagine	109-119	mitochondrially encoded cytochrome b	Homo sapiens	154-158
19595734-0	2009	Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination.	Asparagine	119-129	nitrilase family member 2	Homo sapiens	48-52
19481602-8	2009	Deamination of Asn at position 24 might be responsible for degradation of VIP derivative, and stability and chemical modification studies led us to the successful development of novel VIP derivatives with higher stability and biological functions.	Asparagine	15-18	vasoactive intestinal peptide	Rattus norvegicus	184-187
19941415-0	2009	Rhodopsin: the functional significance of asn-linked glycosylation and other post-translational modifications.	Asparagine	42-45	rhodopsin	Mus musculus	0-9
19941415-3	2009	Rhodopsin is N-glycosylated at Asn-2 and Asn-15 in its extracellular N-terminal domain.	Asparagine	31-34	rhodopsin	Mus musculus	0-9
19941415-3	2009	Rhodopsin is N-glycosylated at Asn-2 and Asn-15 in its extracellular N-terminal domain.	Asparagine	41-44	rhodopsin	Mus musculus	0-9
19464248-0	2009	Assay and purification of omega-amidase/Nit2, a ubiquitously expressed putative tumor suppressor, that catalyzes the deamidation of the alpha-keto acid analogues of glutamine and asparagine.	Asparagine	179-189	nitrilase family, member 2	Rattus norvegicus	26-44
19706515-4	2009	We have mutated the corresponding residue of the eukaryotic glutamate transporters GLT-1 and EAAC1 to asparagine, serine, and cysteine.	Asparagine	102-112	solute carrier family 1 member 2	Homo sapiens	83-88
19706515-4	2009	We have mutated the corresponding residue of the eukaryotic glutamate transporters GLT-1 and EAAC1 to asparagine, serine, and cysteine.	Asparagine	102-112	solute carrier family 1 member 1	Homo sapiens	93-98
19581306-8	2009	Moreover, processed MMP-2 showed enzymatic activity that was enhanced by intermolecular autoproteolytic processing at the Asn(109)-Tyr peptide bond.	Asparagine	122-125	matrix metallopeptidase 2	Homo sapiens	20-25
19589778-6	2009	Kinetic analyses revealed differential contributions toward the functional activity of Hgt1p by these residues and identified Asn-124 in transmembrane domain 1 (TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop region 537-568 containing the highly conserved proline-rich motif to be essential for the transport activity of the protein.	Asparagine	126-129	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	87-92
19555410-2	2009	Phenotypic analysis revealed a high level of photorespiratory ammonium, glutamine/glutamate and asparagine/aspartate in the GLU1 mutant lacking the major ferredoxin-glutamate synthase, indicating that excess photorespiratory ammonium was detoxified into amino acids for transport out of the veins.	Asparagine	96-106	glutamate synthase 1	Arabidopsis thaliana	124-128
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	aurora kinase A	Homo sapiens	0-8
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	aurora kinase B	Homo sapiens	105-113
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	aurora kinase B	Homo sapiens	143-151
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	inner centromere protein	Homo sapiens	168-174
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	aurora kinase A	Homo sapiens	122-130
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	TPX2 microtubule nucleation factor	Homo sapiens	212-216
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	aurora kinase A	Homo sapiens	122-130
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	aurora kinase B	Homo sapiens	143-151
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	inner centromere protein	Homo sapiens	168-174
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	aurora kinase A	Homo sapiens	122-130
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	48-58	TPX2 microtubule nucleation factor	Homo sapiens	212-216
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	aurora kinase A	Homo sapiens	0-8
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	aurora kinase B	Homo sapiens	105-113
19494039-4	2009	Aurora A residue glycine 198 (G198), mutated to asparagine to mimic the aligned asparagine 142 (N142) of Aurora B, causes Aurora A to bind the Aurora B binding partner INCENP but not the Aurora A binding partner TPX2.	Asparagine	80-90	aurora kinase A	Homo sapiens	122-130
19552431-5	2009	Extensive exploration of its structure-activity relationship resulted in a series of highly potent B(2) receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B(2) receptor.	Asparagine	227-230	bradykinin receptor B2	Homo sapiens	99-112
19521992-3	2009	The measured deamidation index of alpha-synuclein was found to be 0.23 for an overall deamidation half-time of 23 days, without or with SDS micelles, owing primarily to the deamidation of Asn(103) and Asn(122).	Asparagine	188-191	synuclein alpha	Homo sapiens	34-49
19521992-3	2009	The measured deamidation index of alpha-synuclein was found to be 0.23 for an overall deamidation half-time of 23 days, without or with SDS micelles, owing primarily to the deamidation of Asn(103) and Asn(122).	Asparagine	201-204	synuclein alpha	Homo sapiens	34-49
19552431-5	2009	Extensive exploration of its structure-activity relationship resulted in a series of highly potent B(2) receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B(2) receptor.	Asparagine	227-230	bradykinin receptor B2	Homo sapiens	242-255
19549823-8	2009	As Asn-194 in eubacterial AlaRS important for Ser misactivation is replaced by Thr-213 in archaeal AlaRS, a different Ser accommodation mechanism is proposed.	Asparagine	3-6	alanyl-tRNA synthetase 1	Homo sapiens	26-31
19581575-7	2009	The importance of the network of hydrogen bonds is further illustrated by mutational studies, which show that substitution of the Asn and Gln residues to Ala compromises the Sup35 fibril stability.	Asparagine	130-133	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	174-179
19478089-5	2009	Within this surface, the Asn-115 residue of human SHH has been documented to associate with HPE when mutated to lysine (N115K).	Asparagine	25-28	sonic hedgehog signaling molecule	Homo sapiens	50-53
19494832-4	2009	However, unlike E1 substrates, which are UBLs with a C-terminal di-glycine sequence, MccB"s substrate, MccA, is a short peptide with an essential C-terminal Asn.	Asparagine	157-160	MccB	Escherichia coli	85-89
19263424-5	2009	This work presents a method named MASA that combines the support vector machine with the sequence and structural characteristics of proteins to identify methylation sites on lysine, arginine, glutamate, and asparagine.	Asparagine	207-217	enolase-phosphatase 1	Homo sapiens	34-38
19429681-5	2009	CPE-binding assays with claudin-3 mutant-transfected HEK293 cells or lysates thereof demonstrated the involvement of Asn(148) and Leu(150) of full-length claudin-3 in the binding.	Asparagine	117-120	claudin 3	Homo sapiens	24-33
19429681-5	2009	CPE-binding assays with claudin-3 mutant-transfected HEK293 cells or lysates thereof demonstrated the involvement of Asn(148) and Leu(150) of full-length claudin-3 in the binding.	Asparagine	117-120	claudin 3	Homo sapiens	154-163
19549823-8	2009	As Asn-194 in eubacterial AlaRS important for Ser misactivation is replaced by Thr-213 in archaeal AlaRS, a different Ser accommodation mechanism is proposed.	Asparagine	3-6	alanyl-tRNA synthetase 1	Homo sapiens	99-104
19401150-1	2009	FIH-1, factor inhibiting hypoxia-inducible factor-1 (HIF-1), regulates oxygen sensing by hydroxylating an asparagine within HIF-alpha.	Asparagine	106-116	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	0-51
19530187-6	2009	Postmortem molecular studies of GNAS, the gene for guanine nucleotide-binding protein, alpha-stimulating activity polypeptide (gene for PHP1A), identified a de novo heterozygous 3 bp in frame deletion predicting a deletion of the asparagine residue at position 377 (deltaN377).	Asparagine	230-240	GNAS complex locus	Homo sapiens	32-36
19584539-2	2009	In the current studies, we report the molecular heterogeneity of TIME-EA4 protein regarding not only amino acid L62V, but also the numbers and linkage patterns of the sugar chain attached to the Asn(22) residue.	Asparagine	195-198	time interval measuring enzyme-esterase A4	Bombyx mori	70-73
19401150-1	2009	FIH-1, factor inhibiting hypoxia-inducible factor-1 (HIF-1), regulates oxygen sensing by hydroxylating an asparagine within HIF-alpha.	Asparagine	106-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
19401150-2	2009	It also hydroxylates asparagines in many proteins containing ankyrin repeats, including Notch1-3, p105 and I?B?.	Asparagine	21-32	notch receptor 1	Homo sapiens	88-94
19401150-2	2009	It also hydroxylates asparagines in many proteins containing ankyrin repeats, including Notch1-3, p105 and I?B?.	Asparagine	21-32	nuclear factor kappa B subunit 1	Homo sapiens	98-102
19401150-5	2009	We also demonstrated hydroxylation of two asparagines in Notch2 and 3, corresponding to Sites 1 and 2 of Notch1, by mass spectrometry for the first time.	Asparagine	42-53	notch receptor 2	Homo sapiens	57-69
19401150-5	2009	We also demonstrated hydroxylation of two asparagines in Notch2 and 3, corresponding to Sites 1 and 2 of Notch1, by mass spectrometry for the first time.	Asparagine	42-53	notch receptor 1	Homo sapiens	105-111
19433443-0	2009	The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.	Asparagine	153-163	RAS p21 protein activator 3	Homo sapiens	15-24
19433443-0	2009	The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.	Asparagine	153-163	RAP1 GTPase activating protein	Homo sapiens	42-72
19433443-8	2009	Finally, a key residue in Rap1-specific GAPs is a catalytic asparagine, the so-called asparagine thumb.	Asparagine	60-70	RAP1A, member of RAS oncogene family	Homo sapiens	26-30
19433443-8	2009	Finally, a key residue in Rap1-specific GAPs is a catalytic asparagine, the so-called asparagine thumb.	Asparagine	86-96	RAP1A, member of RAS oncogene family	Homo sapiens	26-30
19433443-9	2009	By generating a molecular model describing the predicted Rap1-binding site in the RasGRD of GAP1(IP4BP), we show that mutagenesis of individual asparagine or glutamine residues that lie in close proximity to the predicted binding site has no detectable effect on the in vivo Rap1 GAP activity of GAP1(IP4BP).	Asparagine	144-154	RAP1A, member of RAS oncogene family	Homo sapiens	57-61
19433443-9	2009	By generating a molecular model describing the predicted Rap1-binding site in the RasGRD of GAP1(IP4BP), we show that mutagenesis of individual asparagine or glutamine residues that lie in close proximity to the predicted binding site has no detectable effect on the in vivo Rap1 GAP activity of GAP1(IP4BP).	Asparagine	144-154	RAS p21 protein activator 3	Homo sapiens	92-102
19409386-1	2009	In the present study we show in the Xenopus laevis expression system that the proton-coupled amino acid transporter 1 (PAT1, SLC36A1) is glycosylated at asparagine residues N174, N183 and N470.	Asparagine	153-163	solute carrier family 36 member 1	Homo sapiens	119-123
19158835-0	2009	Depletion of L-asparagine supply and apoptosis of leukemia cells induced by human glycosylasparaginase.	Asparagine	13-25	aspartylglucosaminidase	Homo sapiens	82-102
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Asparagine	126-129	subtilisin-like protease	Solanum lycopersicum	9-15
19402713-4	2009	Recombinant FAP cleavage of peptide libraries of short amino acid sequences surrounding the scissile bond, -Pro(12)-Asn(13)-, indicated that P2 Gly and P1 Pro are required, just as we found for APCE.	Asparagine	116-119	fibroblast activation protein alpha	Homo sapiens	12-15
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Asparagine	116-119	subtilisin-like protease	Solanum lycopersicum	9-15
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Asparagine	126-129	subtilisin-like protease	Solanum lycopersicum	9-15
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Asparagine	126-129	subtilisin-like protease	Solanum lycopersicum	9-15
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Asparagine	126-129	subtilisin-like protease	Solanum lycopersicum	9-15
19409386-1	2009	In the present study we show in the Xenopus laevis expression system that the proton-coupled amino acid transporter 1 (PAT1, SLC36A1) is glycosylated at asparagine residues N174, N183 and N470.	Asparagine	153-163	solute carrier family 36 (proton/amino acid symporter), member 1 L homeolog	Xenopus laevis	125-132
19558091-9	2009	Substrates of high positive correlation coefficients with PC1 were L-asparagine, 4-hydroxy benzoic acid and D-malic acid, but D-galacturonic acid, i-erythritol, gamma-hydroxybutyric acid and glucose-1-phosphate showed high negative correlation.	Asparagine	67-79	polycystin 1, transient receptor potential channel interacting	Homo sapiens	58-61
19164286-9	2009	Mutating both residues to asparagine abolishes tTG-catalyzed cross-linking of alpha-syn and tTG-induced inhibition of alpha-syn fibrillization in vitro.	Asparagine	26-36	transglutaminase 2	Homo sapiens	47-50
19245366-3	2009	Although the function(s) of these ARD hydroxylations is unclear, expression of the ARD protein Notch1 was shown to compete efficiently with HIF CAD for asparagine hydroxylation and thus to enhance HIF activity.	Asparagine	152-162	notch receptor 1	Homo sapiens	95-101
19245366-6	2009	In the present study we assay for asparagine hydroxylation in a bioinformatically predicted FIH substrate, the targeting subunit of myosin phosphatase, MYPT1.	Asparagine	34-44	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	152-157
19164286-6	2009	We subjected tTG-catalyzed cross-linked monomeric alpha-syn composed of either wild-type or Gln --> Asn mutants to sequential proteolysis by multiple enzymes and peptide mapping by mass spectrometry.	Asparagine	100-103	transglutaminase 2	Homo sapiens	13-16
19164286-9	2009	Mutating both residues to asparagine abolishes tTG-catalyzed cross-linking of alpha-syn and tTG-induced inhibition of alpha-syn fibrillization in vitro.	Asparagine	26-36	synuclein alpha	Homo sapiens	78-87
19164286-9	2009	Mutating both residues to asparagine abolishes tTG-catalyzed cross-linking of alpha-syn and tTG-induced inhibition of alpha-syn fibrillization in vitro.	Asparagine	26-36	transglutaminase 2	Homo sapiens	92-95
19164286-9	2009	Mutating both residues to asparagine abolishes tTG-catalyzed cross-linking of alpha-syn and tTG-induced inhibition of alpha-syn fibrillization in vitro.	Asparagine	26-36	synuclein alpha	Homo sapiens	118-127
19383790-4	2009	Unlike the case in the structures of water-selective AQPs AqpZ and AQP1, the asparagines of the 2 Asn-Pro-Ala motifs do not hydrogen bond to the same water molecule; instead, they bond to 2 different water molecules in the center of the channel.	Asparagine	77-88	aquaporin 1 (Colton blood group)	Homo sapiens	67-71
19412423-4	2009	The distribution of Thr/Asn genotype at CYP1A1 codon 461 was significantly overrepresented among the patients (23.3%; P = .0422), whereas the Ile/Val genotype at CYP1A1 codon 462 was not significantly different between cases and controls (P = .76).	Asparagine	24-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-46
19375057-6	2009	Mutation profiling of positional candidate genes detected a heterozygous transversion (c. 107A-->G) in exon 2 of the KIT ligand (KITLG) gene, predicted to result in the substitution of a serine residue for an asparagine residue at codon 36 (p.N-->S).	Asparagine	209-219	KIT ligand	Homo sapiens	117-127
19375057-6	2009	Mutation profiling of positional candidate genes detected a heterozygous transversion (c. 107A-->G) in exon 2 of the KIT ligand (KITLG) gene, predicted to result in the substitution of a serine residue for an asparagine residue at codon 36 (p.N-->S).	Asparagine	209-219	KIT ligand	Homo sapiens	129-134
19366592-1	2009	Asn(331) in transmembrane segment 7 of the yeast Saccharomyces cerevisiae transporter Hxt2 has been identified as a single key residue for high-affinity glucose transport by comprehensive chimera approach.	Asparagine	0-3	hexose transporter HXT2	Saccharomyces cerevisiae S288C	86-90
19366592-3	2009	The functional role of Ile(287) in human GLUT1, which corresponds to Asn(331) in Hxt2, was studied by its replacement with each of the other 19 amino acids.	Asparagine	69-72	solute carrier family 2 member 1	Homo sapiens	41-46
19548524-5	2009	The SFP1 encodes potenlially prionogenic protein, as it is enriched with asparagine and glutamine residues.	Asparagine	73-83	zinc-coordinating transcription factor SFP1	Saccharomyces cerevisiae S288C	4-8
19130199-5	2009	An asparagine-to-lysine change was located immediately proximal to a known CD8(+)T cell epitope in NS4B, while a glutamine-to-lysine change was located within a predicted CD8(+)T cell epitope in NS5.	Asparagine	3-13	CD8a molecule	Homo sapiens	75-78
19269662-6	2009	Analysis of PrP sequences suggests that an ability to support amplification of PrP(CWD) in trans-species sPMCA is correlated with the presence of asparagine at position 170 of the substrate species PrP.	Asparagine	146-156	prion protein	Mus musculus	12-15
19269662-6	2009	Analysis of PrP sequences suggests that an ability to support amplification of PrP(CWD) in trans-species sPMCA is correlated with the presence of asparagine at position 170 of the substrate species PrP.	Asparagine	146-156	prion protein	Mus musculus	79-82
19269662-6	2009	Analysis of PrP sequences suggests that an ability to support amplification of PrP(CWD) in trans-species sPMCA is correlated with the presence of asparagine at position 170 of the substrate species PrP.	Asparagine	146-156	prion protein	Mus musculus	79-82
19357306-4	2009	We replaced the Gly-198 of Aurora-A with the equivalent residue Asn-142 of Aurora-B and found that in HeLa cells, Aurora-A(G198N) was recruited to the inner centromere in metaphase and the midzone in anaphase, reminiscent of the Aurora-B localization.	Asparagine	64-67	aurora kinase B	Homo sapiens	75-83
19357306-4	2009	We replaced the Gly-198 of Aurora-A with the equivalent residue Asn-142 of Aurora-B and found that in HeLa cells, Aurora-A(G198N) was recruited to the inner centromere in metaphase and the midzone in anaphase, reminiscent of the Aurora-B localization.	Asparagine	64-67	aurora kinase A	Homo sapiens	114-122
19357306-8	2009	Therefore, we propose that the presence of Gly or Asn at a single site assigns Aurora-A and -B to their respective partners and thus to their distinctive subcellular localizations and functions.	Asparagine	50-53	aurora kinase A	Homo sapiens	79-94
19181663-8	2009	Molecular dynamics results showed that the ordinal increase in flexibility from pseudolysin to MCP-02 and E495, especially the increase from MCP-02 to E495, mainly resulted from the decrease of hydrogen-bond stability in the dynamic structure, which was due to the increase in asparagine, serine, and threonine residues.	Asparagine	277-287	CD46 molecule	Homo sapiens	95-98
19181663-8	2009	Molecular dynamics results showed that the ordinal increase in flexibility from pseudolysin to MCP-02 and E495, especially the increase from MCP-02 to E495, mainly resulted from the decrease of hydrogen-bond stability in the dynamic structure, which was due to the increase in asparagine, serine, and threonine residues.	Asparagine	277-287	CD46 molecule	Homo sapiens	141-144
19176480-6	2009	We also show that, in heterologous expression systems, lipid raft segregation of TRPM8 is favored by glycosylation at the Asn(934) residue of the polypeptide.	Asparagine	122-125	transient receptor potential cation channel subfamily M member 8	Homo sapiens	81-86
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Asparagine	152-155	potassium voltage-gated channel subfamily A regulatory beta subunit 1	Homo sapiens	29-35
20641344-11	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (11).	Asparagine	35-38	alanyl (membrane) aminopeptidase	Mus musculus	118-121
20641511-12	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (12).	Asparagine	35-38	alanyl aminopeptidase, membrane	Homo sapiens	118-121
20641652-12	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (12).	Asparagine	35-38	alanyl aminopeptidase, membrane	Homo sapiens	118-121
19191736-7	2009	Those residues responsible for anchoring the hexose moieties of the dTDP-sugars to the protein include Glu 141, Asn 159, and Asp 160 from one subunit and His 134 from another subunit.	Asparagine	112-115	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	68-72
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Asparagine	152-155	potassium voltage-gated channel subfamily A regulatory beta subunit 2	Homo sapiens	37-43
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Asparagine	152-155	potassium voltage-gated channel subfamily A regulatory beta subunit 3	Homo sapiens	48-54
19116204-1	2009	The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions.	Asparagine	134-144	opioid receptor mu 1	Homo sapiens	82-87
19252254-3	2009	The most common mutation found is the Asn540Lys (asparagine to lysine transition-N540K) in the intracellular tyrosine-kinase (TK1) region.	Asparagine	49-59	thymidine kinase 1	Homo sapiens	126-129
18990090-6	2009	We found that the NST (Asn/Ser/Thr-rich) domain, along with AD1 (acidic domain 1), contributes positively to the transactivation activity of full-length Nrf1.	Asparagine	23-26	nuclear respiratory factor 1	Rattus norvegicus	153-157
18952826-0	2009	The N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylation.	Asparagine	47-50	Fc gamma receptor IIIa	Homo sapiens	32-46
19047480-8	2009	The higher potency is explained by more effective van der Waals interaction of the compounds with Asn(2.61) (hH(1)R) relative to Ser(2.61) (gpH(1)R).	Asparagine	98-101	histamine receptor H1	Homo sapiens	109-115
19183552-5	2009	Mutational analysis identified a single specific alpha-actin residue, Asn-297, that confers this species/isoform folding specificity.	Asparagine	70-73	actin	Saccharomyces cerevisiae S288C	55-60
19038967-4	2009	In this study, we describe an endoglycosidase H-deglycosylated form of TPP1 containing four Asn-linked N-acetylglucosamines that is indistinguishable from fully glycosylated TPP1 in terms of autocatalytic processing of the proform and enzymatic properties of the mature protease.	Asparagine	92-95	tripeptidyl peptidase 1	Homo sapiens	71-75
18952826-5	2009	Our gain-of-function analysis in the Fc gamma RIIIa oligosaccharide at Asn-162 (N-162) confirmed that N-162 is the element required for the high binding affinity to nonfucosylated antibodies, as previously revealed by loss-of-function analyses.	Asparagine	71-74	Fc gamma receptor IIIa	Homo sapiens	37-51
19129457-4	2009	In addition, the presence of an asparagine at residue 283 within the CD4 binding site has been associated with brain-derived envelopes, increased env-CD4 affinity, and enhanced macrophage tropism.	Asparagine	32-42	CD4 molecule	Homo sapiens	69-72
19129457-4	2009	In addition, the presence of an asparagine at residue 283 within the CD4 binding site has been associated with brain-derived envelopes, increased env-CD4 affinity, and enhanced macrophage tropism.	Asparagine	32-42	CD4 molecule	Homo sapiens	150-153
19164517-8	2009	Interestingly, chicken TRPV3 is weakly sensitive to 2-APB, and the equivalent residue at 426 is an asparagine (N).	Asparagine	99-109	transient receptor potential cation channel subfamily V member 3	Gallus gallus	23-28
19116362-1	2009	In transmembrane (TM) domains, tetraspanin KAI1/CD82 contains an Asn, a Gln, and a Glu polar residue.	Asparagine	65-68	CD82 molecule	Homo sapiens	43-47
19116362-1	2009	In transmembrane (TM) domains, tetraspanin KAI1/CD82 contains an Asn, a Gln, and a Glu polar residue.	Asparagine	65-68	CD82 molecule	Homo sapiens	48-52
18952826-0	2009	The N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylation.	Asparagine	47-50	Fc gamma receptor IIIa	Homo sapiens	86-100
19047052-2	2009	Mouse Nrf3 is subject to proteolysis, Asn glycosylation, and deglycosylation reactions.	Asparagine	38-41	nuclear factor, erythroid derived 2, like 3	Mus musculus	6-10
19108589-0	2009	Conserved water mediated H-bonding dynamics of inhibitor, cofactor, Asp 364 and Asn 303 in human IMPDH II.	Asparagine	80-83	inosine monophosphate dehydrogenase 2	Homo sapiens	97-105
19177562-6	2009	To determine functional effects of introduction of Asn into the Walker A sequence, we replaced the Walker-A Thr with Asn in ClpB, a bacterial AAA+ chaperone which reactivates aggregated proteins.	Asparagine	51-54	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	124-128
19177562-6	2009	To determine functional effects of introduction of Asn into the Walker A sequence, we replaced the Walker-A Thr with Asn in ClpB, a bacterial AAA+ chaperone which reactivates aggregated proteins.	Asparagine	117-120	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	124-128
19047052-7	2009	The h region (residues 12-23) was demonstrated to target Nrf3 to the ER and is necessary for its Asn glycosylation.	Asparagine	97-100	nuclear factor, erythroid derived 2, like 3	Mus musculus	57-61
18941114-1	2009	Veltuzumab is a humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to rituximab, except for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), having aspartic acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22 antibody.	Asparagine	273-283	CDR3	Homo sapiens	194-198
18941114-1	2009	Veltuzumab is a humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to rituximab, except for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), having aspartic acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22 antibody.	Asparagine	285-288	CDR3	Homo sapiens	194-198
19176517-3	2009	We confirmed that TSC2 accelerated GTP hydrolysis by Rheb 50-fold through an "asparagine-thumb" mechanism to substitute for the nonfunctional "catalytic" glutamine of Rheb and we determined that catalysis was enthalpy driven.	Asparagine	78-88	TSC complex subunit 2	Homo sapiens	18-22
19167329-1	2009	Asparagine-linked glycosylation of polypeptides in the lumen of the endoplasmic reticulum is catalyzed by the hetero-oligomeric oligosaccharyltransferase (OST).	Asparagine	0-10	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	155-158
19015261-6	2009	We have further identified two functional degradation motifs in Sgo1; that is, a KEN (Lys-Glu-Asn) box and a destruction box (D box).	Asparagine	94-97	shugoshin 1	Homo sapiens	64-68
19272175-3	2009	METHODS: To identify the critical amino acid residues of human EndoG, we replaced the conserved histidine, asparagine, and arginine residues with alanine.	Asparagine	107-117	endonuclease G	Homo sapiens	63-68
19272175-6	2009	His-141, Asn-163, and Asn-172 in the H-N-H motif of EndoG were critical for catalysis and substrate specificity.	Asparagine	9-12	endonuclease G	Homo sapiens	52-57
19272175-6	2009	His-141, Asn-163, and Asn-172 in the H-N-H motif of EndoG were critical for catalysis and substrate specificity.	Asparagine	22-25	endonuclease G	Homo sapiens	52-57
19272175-8	2009	Furthermore, an additional catalytic residue (Asn-251) and an additional metal ion binding site (Glu-271) of human EndoG were identified.	Asparagine	46-49	endonuclease G	Homo sapiens	115-120
20523161-7	2009	The Asn221Ser mutation was significantly associated with the total TFPI levels (Asn/Asn, n = 108, total TFPI = 56.57 +/- 0.88 ng/ml (mean +/- SD) vs. Asn/Ser + Ser/Ser, n = 16, total TFPI = 63.44 +/- 2.28 ng/ml, P = 0.0058).	Asparagine	4-7	tissue factor pathway inhibitor	Homo sapiens	67-71
19106291-1	2009	Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine.	Asparagine	135-145	legumain	Mus musculus	0-25
19106291-1	2009	Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine.	Asparagine	135-145	legumain	Mus musculus	27-30
19343746-3	2009	Hence, Glu484 in pcPAL favors the Friedel-Crafts reaction (see picture, MIO = 4-methylidene imidazol-5-one) whereas an Asn in TAL gives an elimination reaction.	Asparagine	119-122	transaldolase 1	Homo sapiens	126-129
20523161-7	2009	The Asn221Ser mutation was significantly associated with the total TFPI levels (Asn/Asn, n = 108, total TFPI = 56.57 +/- 0.88 ng/ml (mean +/- SD) vs. Asn/Ser + Ser/Ser, n = 16, total TFPI = 63.44 +/- 2.28 ng/ml, P = 0.0058).	Asparagine	4-7	tissue factor pathway inhibitor	Homo sapiens	104-108
20523161-7	2009	The Asn221Ser mutation was significantly associated with the total TFPI levels (Asn/Asn, n = 108, total TFPI = 56.57 +/- 0.88 ng/ml (mean +/- SD) vs. Asn/Ser + Ser/Ser, n = 16, total TFPI = 63.44 +/- 2.28 ng/ml, P = 0.0058).	Asparagine	4-7	tissue factor pathway inhibitor	Homo sapiens	104-108
20523161-7	2009	The Asn221Ser mutation was significantly associated with the total TFPI levels (Asn/Asn, n = 108, total TFPI = 56.57 +/- 0.88 ng/ml (mean +/- SD) vs. Asn/Ser + Ser/Ser, n = 16, total TFPI = 63.44 +/- 2.28 ng/ml, P = 0.0058).	Asparagine	80-83	tissue factor pathway inhibitor	Homo sapiens	67-71
20523161-7	2009	The Asn221Ser mutation was significantly associated with the total TFPI levels (Asn/Asn, n = 108, total TFPI = 56.57 +/- 0.88 ng/ml (mean +/- SD) vs. Asn/Ser + Ser/Ser, n = 16, total TFPI = 63.44 +/- 2.28 ng/ml, P = 0.0058).	Asparagine	80-83	tissue factor pathway inhibitor	Homo sapiens	67-71
19528530-2	2009	In order to investigate the functional role of this processing and its effect on folding assembly, wild-type GluA2 and its mutant cDNA (mGluA2), in which the conserved processing site (Asn-Gly) at the junction between the acidic and basic chains was replaced with Ala-Ala, were expressed under the control of the endosperm-specific GluB1 promoter in the mutant rice a123 line lacking glutelin GluA1, GluA2, and GluB4.	Asparagine	185-188	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	136-142
19646346-2	2009	Proteinase 3 (PR3), the main target antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener"s granulomatosis (WG), contains two Asn-linked glycosylation sites.	Asparagine	155-158	proteinase 3	Homo sapiens	0-12
19646346-2	2009	Proteinase 3 (PR3), the main target antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener"s granulomatosis (WG), contains two Asn-linked glycosylation sites.	Asparagine	155-158	proteinase 3	Homo sapiens	14-17
20445800-5	2009	As hypothesized, patients carrying low ROS producing eNOS Glu298Asp asparagine allele showed an increased hazard of death compared to homozygous carriers of the glutamine allele (hazard ratio (HR): 2.10, 95% confidence interval (CI): 1.01-4.38).	Asparagine	68-78	nitric oxide synthase 3	Homo sapiens	53-57
18448192-2	2009	Triticain alpha, beta and gamma were constituted with 461, 472 and 365 amino acid residues, respectively, and had Cys-His-Asn catalytic triads as well as signal and propeptide sequences.	Asparagine	122-125	oryzain alpha chain	Triticum aestivum	0-15
19140836-2	2009	The novel B*4076 is identical to B*400101 with an exception of one base substitution at position 239(C&gt;A)of exon 2 resulting in codon #80 changed from AAC (Asn) to AAA (Lys).	Asparagine	159-162	glycine-N-acyltransferase	Homo sapiens	154-157
18852263-7	2008	We also found that glycosylation of CD151 is also critical; Asn(159) --&gt; Gln mutation in the large extracellular loop did not affect interactions of CD151 with other tetraspanins or alpha3beta1 but negated its modulatory function.	Asparagine	60-63	CD151 molecule (Raph blood group)	Homo sapiens	36-41
18984596-3	2008	To address this hypothesis directly, we rationally identified a point mutation to Galphai subunits that renders a selective loss-of-function for GoLoco motif binding, namely an asparagine-to-isoleucine substitution in the alphaD-alphaE loop of the Galpha helical domain.	Asparagine	177-187	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	82-88
19052230-8	2008	The reduction of the disulfide bond in SOD1 with metal ions depleted results in a flexible Glu-49-Asn-53 loop, which, in turn, disrupts dimer formation.	Asparagine	98-101	superoxide dismutase 1	Homo sapiens	39-43
18991397-10	2008	In addition, the biotinylated SP-D pulled down the mutant sMD-2 with Asn(26) --&gt; Ala and Asn(114) --&gt; Ala substitutions, which lacks the consensus for N-glycosylation.	Asparagine	69-72	surfactant protein D	Homo sapiens	30-34
19053285-4	2008	One of these residues, T106 in HePTP, is either an aspartate or asparagine in nearly every other PTP.	Asparagine	64-74	protein tyrosine phosphatase non-receptor type 7	Homo sapiens	31-36
19053285-4	2008	One of these residues, T106 in HePTP, is either an aspartate or asparagine in nearly every other PTP.	Asparagine	64-74	protein tyrosine phosphatase receptor type U	Homo sapiens	33-36
18991397-10	2008	In addition, the biotinylated SP-D pulled down the mutant sMD-2 with Asn(26) --&gt; Ala and Asn(114) --&gt; Ala substitutions, which lacks the consensus for N-glycosylation.	Asparagine	69-72	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	58-63
18991397-10	2008	In addition, the biotinylated SP-D pulled down the mutant sMD-2 with Asn(26) --&gt; Ala and Asn(114) --&gt; Ala substitutions, which lacks the consensus for N-glycosylation.	Asparagine	92-95	surfactant protein D	Homo sapiens	30-34
18991397-10	2008	In addition, the biotinylated SP-D pulled down the mutant sMD-2 with Asn(26) --&gt; Ala and Asn(114) --&gt; Ala substitutions, which lacks the consensus for N-glycosylation.	Asparagine	92-95	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	58-63
19038921-5	2008	Additionally, no N-glycosylation was found in the recombinant human alpha-LA, whereas the endogenous bovine alpha-LA was glycosylated at the unusual site (71)Asn-Ile-(73)Cys.	Asparagine	158-161	lactalbumin alpha	Homo sapiens	108-116
19041604-5	2008	There are several other factors which influence the role of asparaginase use in adults, including the level and sustainability of asparagine depletion, schedule, dosing, and form of asparaginase and the consequent toxicities and immunogenicity reactions.	Asparagine	130-140	asparaginase	Homo sapiens	60-72
19032691-2	2008	This work aimed to investigate the occurrence of Asn and Ser FSHR gene variants and its relationship with seminal anti-Mullerian hormone (AMH) among normozoospermic and infertile oligoasthenozoospermic (OAT) males.	Asparagine	49-52	anti-Mullerian hormone	Homo sapiens	138-141
19032691-6	2008	The results showed that the frequency of FSHR gene variants among fertile men was 46.7% Asn/Asn (N680S), 33.3% Asn/Ser, and 20% Ser/Ser, whereas among OAT men were 34.6%, 38.5% and 26.9% respectively with nonsignificant differences.	Asparagine	88-91	follicle stimulating hormone receptor	Homo sapiens	41-45
19032691-6	2008	The results showed that the frequency of FSHR gene variants among fertile men was 46.7% Asn/Asn (N680S), 33.3% Asn/Ser, and 20% Ser/Ser, whereas among OAT men were 34.6%, 38.5% and 26.9% respectively with nonsignificant differences.	Asparagine	92-95	follicle stimulating hormone receptor	Homo sapiens	41-45
19032691-6	2008	The results showed that the frequency of FSHR gene variants among fertile men was 46.7% Asn/Asn (N680S), 33.3% Asn/Ser, and 20% Ser/Ser, whereas among OAT men were 34.6%, 38.5% and 26.9% respectively with nonsignificant differences.	Asparagine	92-95	follicle stimulating hormone receptor	Homo sapiens	41-45
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	51-54	anti-Mullerian hormone	Homo sapiens	42-45
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	51-54	follicle stimulating hormone receptor	Homo sapiens	70-74
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	55-58	anti-Mullerian hormone	Homo sapiens	42-45
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	55-58	follicle stimulating hormone receptor	Homo sapiens	70-74
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	55-58	anti-Mullerian hormone	Homo sapiens	42-45
19032691-8	2008	There was significant increase in seminal AMH with Asn/Asn variant of FSHR gene than those with Asn/Ser or Ser/Ser.	Asparagine	55-58	follicle stimulating hormone receptor	Homo sapiens	70-74
19032691-10	2008	However, when correlated with seminal AMH values, there was an increase in Asn/Asn in men with high seminal AMH.	Asparagine	75-78	anti-Mullerian hormone	Homo sapiens	38-41
19032691-10	2008	However, when correlated with seminal AMH values, there was an increase in Asn/Asn in men with high seminal AMH.	Asparagine	75-78	anti-Mullerian hormone	Homo sapiens	108-111
19032691-10	2008	However, when correlated with seminal AMH values, there was an increase in Asn/Asn in men with high seminal AMH.	Asparagine	79-82	anti-Mullerian hormone	Homo sapiens	38-41
19032691-10	2008	However, when correlated with seminal AMH values, there was an increase in Asn/Asn in men with high seminal AMH.	Asparagine	79-82	anti-Mullerian hormone	Homo sapiens	108-111
18948218-3	2008	Immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein, p53, and T-cell proliferation in response to lysine, asparagine, and glutamic acid.	Asparagine	168-178	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	115-118
18536010-5	2008	Altered glycosylation caused significant conformational changes for most of the key functional regions of the I-like domain of beta1 integrin, including the metal ion-dependent adhesion site that contains a DLSYS motif, and other critical residues for ligand binding (Asn-224, Glu-229, Asp-233, Asp-267, and Asp-295).	Asparagine	268-271	integrin subunit beta 1	Homo sapiens	127-141
18855427-2	2008	To address the importance of TM domain packing density for receptor functionality, we examined a set of asparagine mutants in the TM domain of the erythropoietin receptor (EpoR).	Asparagine	104-114	erythropoietin receptor	Homo sapiens	147-170
18824048-6	2008	Removal of the C-terminal asparagine from AtPep1(9-23), resulted in a decrease in activity (12 max approximately 100 nM).	Asparagine	26-36	precursor of peptide 1	Arabidopsis thaliana	42-48
19036977-1	2008	RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV).	Asparagine	78-81	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	152-161
18491227-0	2008	Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD.	Asparagine	19-22	cadherin 1	Homo sapiens	56-66
18836295-7	2008	Recently, some studies indicated that coupling special ligand like NGR (N: asparagine, G: glycine, R: arginine) peptide targeting to tumor blood vessels with delivery system can enhance the efficacy of gene transfection.	Asparagine	75-85	reticulon 4 receptor	Homo sapiens	67-70
18491227-2	2008	In a previous study, we demonstrated that all of four potential N-glycosylation sites in E-cadherin are occupied by N-glycans in human breast carcinoma cells in vivo and the elimination of N-glycan at Asn-633 dramatically affected E-cadherin expression and made it degraded.	Asparagine	201-204	cadherin 1	Homo sapiens	89-99
18491227-2	2008	In a previous study, we demonstrated that all of four potential N-glycosylation sites in E-cadherin are occupied by N-glycans in human breast carcinoma cells in vivo and the elimination of N-glycan at Asn-633 dramatically affected E-cadherin expression and made it degraded.	Asparagine	201-204	cadherin 1	Homo sapiens	231-241
18491227-9	2008	In conclusion, this study revealed that N-glycosylation at Asn-633 is essential for E-cadherin expression, folding and trafficking.	Asparagine	59-62	cadherin 1	Homo sapiens	84-94
18676678-6	2008	Further investigation showed that a single amino acid residue, lysine 320 in CXCR2 and asparagine 311 in CXCR1, plays a predominant role in describing the relative antagonism of the two compounds.	Asparagine	87-97	C-X-C chemokine receptor type 2	Bos taurus	105-110
19140571-1	2008	L-asparaginase is a hydrolase that catalyzes the conversion of L-asparagine--an endogenous amino acid necessary for the function of some neoplastic cells, such as lymphoblasts.	Asparagine	63-75	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
18607693-6	2008	Monotransamidation of insulin aspart in the presence of ethylenediamine was observed at all of the six possible Asn/Gln residues with Asn(A21) having the highest propensity to react with ethylenediamine.	Asparagine	112-115	insulin	Homo sapiens	22-29
18607693-6	2008	Monotransamidation of insulin aspart in the presence of ethylenediamine was observed at all of the six possible Asn/Gln residues with Asn(A21) having the highest propensity to react with ethylenediamine.	Asparagine	134-137	insulin	Homo sapiens	22-29
19140571-3	2008	Depletion of L-asparagine from plasma by L-asparaginase results in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis.	Asparagine	13-25	asparaginase and isoaspartyl peptidase 1	Homo sapiens	41-55
18687868-2	2008	Previous crystallographic studies of Efb-C bound to its cognate subdomain of human C3 (C3d) identified Arg-131 and Asn-138 of Efb-C as key residues for its activity.	Asparagine	115-118	endogenous retrovirus group K member 13	Homo sapiens	83-90
18764811-2	2008	The novel allele differs from B*44020101 by a single nucleotide change in exon 3 at nucleotide 453 (C--&gt;G), which changes codon 127 from asparagine (AAC) to lysine (AAG) explaining some aberrant B44 serology results in 2003.	Asparagine	140-150	glycine-N-acyltransferase	Homo sapiens	152-155
18778325-2	2008	DRB1*0474 differs from DRB1*040701 by two nucleotide residues resulting in a single Thr --&gt; Asn substitution at codon 77.	Asparagine	95-98	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
18764811-2	2008	The novel allele differs from B*44020101 by a single nucleotide change in exon 3 at nucleotide 453 (C--&gt;G), which changes codon 127 from asparagine (AAC) to lysine (AAG) explaining some aberrant B44 serology results in 2003.	Asparagine	140-150	N-methylpurine DNA glycosylase	Homo sapiens	168-171
18778325-2	2008	DRB1*0474 differs from DRB1*040701 by two nucleotide residues resulting in a single Thr --&gt; Asn substitution at codon 77.	Asparagine	95-98	major histocompatibility complex, class II, DR beta 1	Homo sapiens	23-27
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	CD44 molecule (Indian blood group)	Homo sapiens	26-30
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	CD44 molecule (Indian blood group)	Homo sapiens	184-188
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	CD44 molecule (Indian blood group)	Homo sapiens	184-188
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	membrane metalloendopeptidase	Homo sapiens	398-401
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	membrane metalloendopeptidase	Homo sapiens	403-430
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	intercellular adhesion molecule 2	Homo sapiens	444-450
18703501-7	2008	Mass spectrometry experiments showed that CA IX contains an intramolecular disulfide bridge (Cys(119)-Cys(299)) and a unique N-linked glycosylation site (Asn(309)) that bears high mannose-type glycan structures.	Asparagine	154-157	carbonic anhydrase 9	Homo sapiens	42-47
18837996-8	2008	The gp120"s C2 region asparagine 283 (N283) has been previously associated with macrophage tropism, brain infection, lower CD4 dependence and higher CD4 affinity.	Asparagine	22-32	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	4-9
18837996-8	2008	The gp120"s C2 region asparagine 283 (N283) has been previously associated with macrophage tropism, brain infection, lower CD4 dependence and higher CD4 affinity.	Asparagine	22-32	CD4 molecule	Homo sapiens	123-126
18837996-8	2008	The gp120"s C2 region asparagine 283 (N283) has been previously associated with macrophage tropism, brain infection, lower CD4 dependence and higher CD4 affinity.	Asparagine	22-32	CD4 molecule	Homo sapiens	149-152
18524885-4	2008	In the present study, we show that the addition of an asparagine-linked glycosylation site to the N terminus of the human trace amine associated receptor 1 (TAAR1) is sufficient to enable its plasma membrane expression, and thus its pharmacological characterization with a novel cAMP EPAC (exchange protein directly activated by cAMP) protein based bioluminescence resonance energy transfer (BRET) biosensor.	Asparagine	54-64	trace amine associated receptor 1	Homo sapiens	122-155
18850054-2	2008	As an oxygen-sensitive attenuator, factor inhibiting HIF-1 (FIH) hydroxylates a conserved asparagine residue within the C-terminal transactivation domain of HIF-1alpha under normoxia and moderate hypoxia.	Asparagine	90-100	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	157-167
18574027-3	2008	Recent studies have shown that NGR can rapidly convert to isoaspartate-glycine-arginine (isoDGR) by asparagine deamidation, generating alpha(v)beta(3) ligands capable of affecting endothelial cell functions and tumor growth.	Asparagine	100-110	reticulon 4 receptor	Homo sapiens	31-34
18706439-2	2008	We discovered a novel C312A transversion in exon 2 of the human GUCA1A gene, replacing Asn-104 (N104) in GCAP1 with Lys (K), in two affected members of a family with dominant cone dystrophy.	Asparagine	87-90	guanylate cyclase activator 1A	Homo sapiens	64-70
18571493-3	2008	The cold inactivation was prevented by a mutation of Thr177 with the corresponding residue, Asn, in cold-stable pig DHRS4, where this residue is hydrogen-bonded to Asn165 in a substrate-binding loop of other subunit.	Asparagine	92-95	dehydrogenase/reductase SDR family member 4	Sus scrofa	116-121
18702513-6	2008	Asn-containing Leu 9 and Leu 12 peptides were synthesized with a single Asn residue located either one amino acid (N+/-1) or one turn of the helix (N+/-4) in either direction from its native position.	Asparagine	0-3	CD7 molecule	Homo sapiens	15-20
18701674-7	2008	Complementation assays of the ccc2 mutant of yeast using chimeric HMA5 proteins revealed that N923T of the Cvi allele, which was identified in the tightly conserved domain N(x)(6)YN(x)(4)P (where the former asparagine was substituted by threonine), is a cause of dysfunction of the Cvi HMA5 allele.	Asparagine	207-217	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	30-34
18806884-4	2008	RESULTS: A higher frequency of the Asn/Asn genotype of EDN1 was found in individuals with at least 10 years of diabetes and no retinopathy (controls) compared with DR patients with any duration of diabetes (DR: 2.3%; control: 11.0%; p=0.0002).	Asparagine	35-38	endothelin 1	Homo sapiens	55-59
18806884-4	2008	RESULTS: A higher frequency of the Asn/Asn genotype of EDN1 was found in individuals with at least 10 years of diabetes and no retinopathy (controls) compared with DR patients with any duration of diabetes (DR: 2.3%; control: 11.0%; p=0.0002).	Asparagine	39-42	endothelin 1	Homo sapiens	55-59
18524885-4	2008	In the present study, we show that the addition of an asparagine-linked glycosylation site to the N terminus of the human trace amine associated receptor 1 (TAAR1) is sufficient to enable its plasma membrane expression, and thus its pharmacological characterization with a novel cAMP EPAC (exchange protein directly activated by cAMP) protein based bioluminescence resonance energy transfer (BRET) biosensor.	Asparagine	54-64	trace amine associated receptor 1	Homo sapiens	157-162
18393942-4	2008	Plasmid-shuffling analysis revealed that Asn(600), Arg(694) and Arg(704) are essential for the function of Orc1p.	Asparagine	41-44	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	107-112
18544529-4	2008	Recent mutagenesis studies on the TLR3 ECD revealed that TLR3 activation depends on a single binding site on the nonglycosylated surface in the C-terminal region, comprising H539 and several asparagines within LRR17 to -20.	Asparagine	191-202	toll like receptor 3	Homo sapiens	34-38
18544529-4	2008	Recent mutagenesis studies on the TLR3 ECD revealed that TLR3 activation depends on a single binding site on the nonglycosylated surface in the C-terminal region, comprising H539 and several asparagines within LRR17 to -20.	Asparagine	191-202	toll like receptor 3	Homo sapiens	57-61
18505723-7	2008	Edman degradation analysis of a beta-arrestin 1 C-terminal fragment fused to enhanced green fluorescent protein confirmed the major cleavage to be after Phe(388) and a minor cleavage after Asn(375).	Asparagine	189-192	arrestin beta 1	Bos taurus	32-47
18384503-8	2008	High and low expressions of AS genes in the roots were associated with high and low ratios of Asn/Asp transported to the shoot through xylem.	Asparagine	94-97	asparagine synthetase	Glycine max	28-30
18611963-5	2008	Here we show that the Lsm4p subunit and its asparagine-rich C-terminus are prone to aggregation, and that this tendency to aggregate promotes efficient accumulation of Lsm1-7p in P-bodies.	Asparagine	44-54	Lsm1p	Saccharomyces cerevisiae S288C	168-172
18550774-3	2008	Our results showed that after agonist stimulation, the recycle of a mutant MOR that lacks the C-terminal residues after Asn(362) (MOR362T) was greatly decreased, whereas a C-terminal phosphorylation sites-mutated MOR (MOR3A), which is deficient in agonist-induced phosphorylation recycled back to the membrane at a level comparable to that of the wild-type receptor, however, interestingly at a slower rate.	Asparagine	120-123	opioid receptor mu 1	Homo sapiens	75-78
18550774-3	2008	Our results showed that after agonist stimulation, the recycle of a mutant MOR that lacks the C-terminal residues after Asn(362) (MOR362T) was greatly decreased, whereas a C-terminal phosphorylation sites-mutated MOR (MOR3A), which is deficient in agonist-induced phosphorylation recycled back to the membrane at a level comparable to that of the wild-type receptor, however, interestingly at a slower rate.	Asparagine	120-123	opioid receptor mu 1	Homo sapiens	130-133
18499674-4	2008	Studies of the melting profiles of the THBS-2 signature domain proteins with Asn or Ser at position 702 (homologous to 700 in THBS-1) revealed that the impact of the Ser allele is similar in both THBS-1 and THBS-2.	Asparagine	77-80	thrombospondin 2	Homo sapiens	39-45
18499674-5	2008	Structure determination of the Ser(702) THBS-2 variant in 2 mm calcium showed that repeat 1C contains two bound calcium ions as in the crystal of the Asn(702) protein, including the ion that is coordinated by Asn(702), and is associated with changes in conformation of repeat 1C and the adjacent EGF-like modules.	Asparagine	150-153	thrombospondin 2	Homo sapiens	40-46
18499674-5	2008	Structure determination of the Ser(702) THBS-2 variant in 2 mm calcium showed that repeat 1C contains two bound calcium ions as in the crystal of the Asn(702) protein, including the ion that is coordinated by Asn(702), and is associated with changes in conformation of repeat 1C and the adjacent EGF-like modules.	Asparagine	209-212	thrombospondin 2	Homo sapiens	40-46
18480047-1	2008	Asparagine deamidation at the NGR sequence in the 5th type I repeat of fibronectin (FN-I5) generates isoDGR, an alphavbeta3 integrin-binding motif regulating endothelial cell adhesion and proliferation.	Asparagine	0-10	reticulon 4 receptor	Homo sapiens	30-33
18625081-10	2008	This phenotype was not observed when the phosphorylatable Asp74 of ARR22 was changed to either a dominant-active Glu or a dominant-inactive Asn.	Asparagine	140-143	response regulator 22	Arabidopsis thaliana	67-72
18480047-1	2008	Asparagine deamidation at the NGR sequence in the 5th type I repeat of fibronectin (FN-I5) generates isoDGR, an alphavbeta3 integrin-binding motif regulating endothelial cell adhesion and proliferation.	Asparagine	0-10	fibronectin 1	Homo sapiens	71-82
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	28-31	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-3	2008	RXFP1 contains six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346, which are highly conserved across species.	Asparagine	90-93	relaxin family peptide receptor 1	Homo sapiens	0-5
18533687-10	2008	In particular, N-glycosylation at Asn-303 of RXFP1 was required for optimal intracellular cAMP signaling.	Asparagine	34-37	relaxin family peptide receptor 1	Homo sapiens	45-50
18430863-3	2008	In the present study, we further characterize the human mGluR2 (hmGluR2) potentiator binding site by showing that the substitution of the three amino acids found to be required for hmGluR2 potentiation, specifically Ser(688), Gly(689), and Asn(735), with the homologous hmGluR3 amino acids, inactivates the positive allosteric modulator activity of several structurally unique mGluR2 potentiators.	Asparagine	240-243	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	56-62
18988464-1	2008	Native and chiral modified (with non-enzymatic Asn racemization) NR1-binding core of NMDA-receptor was modelled by means of molecular dynamic ligand modelling.	Asparagine	47-50	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	65-68
18566480-1	2008	The factor-inhibiting hypoxia-inducible factor (FIH) hydroxylates the asparagine 803 (Asn803) residue of the hypoxia-inducible factor 1alpha (HIF-1alpha), and the modification abrogates the transcriptional activity of HIF-1alpha.	Asparagine	70-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-140
18566480-1	2008	The factor-inhibiting hypoxia-inducible factor (FIH) hydroxylates the asparagine 803 (Asn803) residue of the hypoxia-inducible factor 1alpha (HIF-1alpha), and the modification abrogates the transcriptional activity of HIF-1alpha.	Asparagine	70-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-152
18566480-1	2008	The factor-inhibiting hypoxia-inducible factor (FIH) hydroxylates the asparagine 803 (Asn803) residue of the hypoxia-inducible factor 1alpha (HIF-1alpha), and the modification abrogates the transcriptional activity of HIF-1alpha.	Asparagine	70-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	218-228
18430863-3	2008	In the present study, we further characterize the human mGluR2 (hmGluR2) potentiator binding site by showing that the substitution of the three amino acids found to be required for hmGluR2 potentiation, specifically Ser(688), Gly(689), and Asn(735), with the homologous hmGluR3 amino acids, inactivates the positive allosteric modulator activity of several structurally unique mGluR2 potentiators.	Asparagine	240-243	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	65-71
18422648-11	2008	The interest derives from the observation that an individual with this Ile mutated to Asn, in the KH2 domain of fragile X mental retardation protein, exhibits a particularly severe form of the syndrome.	Asparagine	86-89	fragile X messenger ribonucleoprotein 1	Homo sapiens	112-148
18426857-0	2008	Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.	Asparagine	162-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-113
18426857-4	2008	The other is hydroxylation of HIF-1alpha-asparagine, which reduces the affinity of HIF-1alpha for its coactivator, cAMP responsive element binding protein/p300.	Asparagine	41-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
18426857-4	2008	The other is hydroxylation of HIF-1alpha-asparagine, which reduces the affinity of HIF-1alpha for its coactivator, cAMP responsive element binding protein/p300.	Asparagine	41-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
18426857-4	2008	The other is hydroxylation of HIF-1alpha-asparagine, which reduces the affinity of HIF-1alpha for its coactivator, cAMP responsive element binding protein/p300.	Asparagine	41-51	E1A binding protein p300	Homo sapiens	155-159
18426857-5	2008	We examined the effects of the NO donor SNAP on proline and asparagine hydroxylation of HIF-1alpha peptides by measuring the activities of the corresponding enzymes, HIF-1alpha-specific proline hydroxylase 2 (PHD2) and the HIF-1alpha-specific asparagine hydroxylase, designated factor inhibiting HIF-1alpha (FIH-1), respectively.	Asparagine	60-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-98
18426857-9	2008	Un-like PHD2, asparagine hydroxylation by FIH-1 was directly inhibited by SNAP, but again only when reducing agents were limiting.	Asparagine	14-24	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	42-47
18434309-7	2008	At both ends, TAPL favors positively charged, aromatic, or hydrophobic residues and disfavors negatively charged residues as well as asparagine and methionine.	Asparagine	133-143	ATP binding cassette subfamily B member 9	Homo sapiens	14-18
20641421-26	2004	It contains a carboxy terminus lysine residue separated from VIP-asparagine by a gamma-aminobutyric acid spacer, and N2S2 is used as the chelating agent.	Asparagine	65-75	vasoactive intestinal peptide	Homo sapiens	61-64
18378673-8	2008	Interestingly, construction and kinetic analyses of a series of UGT74F1/F2 chimeras have revealed that mutating a single amino acid distal to the active site, Asn-142, can lead to the development of a new GT with a more constrained regiospecificity.	Asparagine	159-162	UDP-glycosyltransferase 74 F1	Arabidopsis thaliana	64-71
18359283-3	2008	Previous work showed that P450(cin) (CYP176A1), which contains an Asn instead of the conserved Thr, is fully functional in the catalytic oxidation of cineole [D.B.	Asparagine	66-69	pyridoxal phosphatase	Homo sapiens	26-35
18359283-10	2008	To determine whether the substitution of Asn for Thr is specific or general, the conserved Thr252 in P450(cam) (CYP101) was mutated to generate the T252N, T252N/V253T, and T252A mutants.	Asparagine	41-44	calmodulin 3	Homo sapiens	101-110
18343219-0	2008	Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding.	Asparagine	8-11	prion protein	Mus musculus	44-47
18381282-2	2008	The prion-forming domain of the yeast Sup35 protein is rich in glutamine, asparagine, tyrosine, and glycine residues, which may define its prion properties.	Asparagine	74-84	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	38-43
18340083-0	2008	Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase.	Asparagine	17-20	GPI-anchored HDL-binding protein 1	Mus musculus	33-40
18340083-0	2008	Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase.	Asparagine	17-20	lipoprotein lipase	Mus musculus	128-146
18340083-3	2008	Here, we show that mouse GPIHBP1 is N-glycosylated at Asn-76 within the Ly-6 domain.	Asparagine	54-57	GPI-anchored HDL-binding protein 1	Mus musculus	25-32
18340083-3	2008	Here, we show that mouse GPIHBP1 is N-glycosylated at Asn-76 within the Ly-6 domain.	Asparagine	54-57	lymphocyte antigen 6 complex	Mus musculus	72-76
18410496-7	2008	Here we demonstrate that Mid2p contains a single high mannose N-linked glycan at position Asn-35.	Asparagine	90-93	Mid2p	Saccharomyces cerevisiae S288C	25-30
18498744-5	2008	HIF transcriptional activity is further tuned by FIH1-mediated asparagine hydroxylation.	Asparagine	63-73	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	49-53
18343219-5	2008	The majority of mutant PrP with substitutions at the Asn residues of the N-linked glycosylation sites were conversion-competent, whereas most mutant PrP with substitutions at the Thr residues were conversion-incompetent.	Asparagine	53-56	prion protein	Mus musculus	23-26
18319257-0	2008	Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2.	Asparagine	17-27	solute carrier family 38 member 2	Homo sapiens	118-123
18319257-7	2008	These results were interpreted as a reduction of Na(+) affinity caused by the Asn(82) mutations, suggesting that these mutations interfere with the interaction of SNAT2 with the sodium ion.	Asparagine	78-81	solute carrier family 38 member 2	Homo sapiens	163-168
18319257-9	2008	Our results demonstrate a direct or indirect involvement of Asn(82) in Na(+) coordination by SNAT2.	Asparagine	60-63	solute carrier family 38 member 2	Homo sapiens	93-98
18465072-8	2008	In conclusion, women with a lysine (GG genotype) at position 19 of the OCIL protein displayed lower BMD at femoral neck and at lumbar spine sites than women having an asparagine residue.	Asparagine	167-177	C-type lectin domain family 2 member D	Homo sapiens	71-75
18454848-9	2008	This study enabled us to show an increase in risk of breast cancer with no oral contraceptive users and with women exhibiting a waist-to-hip ratio (WHR) &gt; 0.85 for Asn homozygous for ERCC2 312.	Asparagine	167-170	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	186-191
18053795-2	2008	This cross-link provides precisely the evidence needed to support our earlier proposal that collision of the PLN transmembrane helix at Asn(27) with the cytosolic extension of M4 at Leu(321) leads to unwinding of the helix.	Asparagine	136-139	phospholamban	Homo sapiens	109-112
18304667-2	2008	It has been shown that Asn residues are the most susceptible at extreme alkaline pH: here, we show that replacement of all three Asn residues within the IgG-binding domain of PrtG only improves stability towards caustic alkali by about 8-fold.	Asparagine	23-26	protogenin	Homo sapiens	175-179
18304667-2	2008	It has been shown that Asn residues are the most susceptible at extreme alkaline pH: here, we show that replacement of all three Asn residues within the IgG-binding domain of PrtG only improves stability towards caustic alkali by about 8-fold.	Asparagine	129-132	protogenin	Homo sapiens	175-179
17979184-2	2008	The ectodomain of human E-cadherin contains four potential N-glycosylation sites at Asn residues 554, 566, 618, and 633.	Asparagine	84-87	cadherin 1	Homo sapiens	24-34
17979184-5	2008	Removal of N-glycan at Asn-633 dramatically affected E-cadherin stability.	Asparagine	23-26	cadherin 1	Homo sapiens	53-63
17979184-7	2008	Moreover, N-glycans at Asn-554 and Asn-566 were found to affect E-cadherin-mediated calcium-dependent cell-cell adhesion, and removal of either of the two N-glycans caused a significant decrease in calcium-dependent cell-cell adhesion accompanied with elevated cell migration.	Asparagine	23-26	cadherin 1	Homo sapiens	64-74
17979184-7	2008	Moreover, N-glycans at Asn-554 and Asn-566 were found to affect E-cadherin-mediated calcium-dependent cell-cell adhesion, and removal of either of the two N-glycans caused a significant decrease in calcium-dependent cell-cell adhesion accompanied with elevated cell migration.	Asparagine	35-38	cadherin 1	Homo sapiens	64-74
18309292-5	2008	It shows that the Thr61 of Rap is away from the active site and that an invariant asparagine of RapGAPs, the Asn-thumb, takes over the role of the cis-glutamine of Ras, Rho or Ran.	Asparagine	82-92	LDL receptor related protein associated protein 1	Homo sapiens	27-30
18541474-6	2008	Importantly, this method directly detects ASNS protein, the functional entity that may be synthesizing sufficient asparagine to render leukemia cells resistant to asparaginase-treatment.	Asparagine	114-124	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	42-46
18171325-1	2008	In the present study we show that the interaction of the CaM (calmodulin)-binding domain (Lys(3614)-Asn(3643)) with the Cys(4114)-Asn(4142) region (a region included in the CaM-like domain) serves as an intrinsic regulator of the RyR1 (type-1 ryanodine receptor).	Asparagine	100-103	ryanodine receptor 1	Homo sapiens	230-234
18171325-1	2008	In the present study we show that the interaction of the CaM (calmodulin)-binding domain (Lys(3614)-Asn(3643)) with the Cys(4114)-Asn(4142) region (a region included in the CaM-like domain) serves as an intrinsic regulator of the RyR1 (type-1 ryanodine receptor).	Asparagine	130-133	ryanodine receptor 1	Homo sapiens	230-234
18171325-8	2008	These results suggest that the Lys(3614)-Asn(3643) and Cys(4114)-Asn(4142) regions of RyR1 interact with each other in a Ca2+- and agonist-dependent manner, and this serves as a mechanism of Ca2+- and agonist-dependent activation of the RyR1 Ca2+ channel.	Asparagine	41-44	ryanodine receptor 1	Homo sapiens	86-90
18171325-8	2008	These results suggest that the Lys(3614)-Asn(3643) and Cys(4114)-Asn(4142) regions of RyR1 interact with each other in a Ca2+- and agonist-dependent manner, and this serves as a mechanism of Ca2+- and agonist-dependent activation of the RyR1 Ca2+ channel.	Asparagine	65-68	ryanodine receptor 1	Homo sapiens	86-90
18309292-5	2008	It shows that the Thr61 of Rap is away from the active site and that an invariant asparagine of RapGAPs, the Asn-thumb, takes over the role of the cis-glutamine of Ras, Rho or Ran.	Asparagine	82-92	RAN, member RAS oncogene family	Homo sapiens	176-179
18322206-2	2008	This regulatory mechanism is usually described by mutually exclusive interactions of KIR2DL1 with C2 having lysine 80, and KIR2DL2/3 with C1 having asparagine 80.	Asparagine	148-158	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	123-130
18179816-4	2008	RESULTS: Genomic and cDNA sequencing demonstrated a novel NEMO missense mutation, 337G->A, predicted to cause a D113N (aspartic acid to asparagine) substitution in the first coiled-coil region of the NEMO protein.	Asparagine	136-146	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	58-62
18179816-4	2008	RESULTS: Genomic and cDNA sequencing demonstrated a novel NEMO missense mutation, 337G->A, predicted to cause a D113N (aspartic acid to asparagine) substitution in the first coiled-coil region of the NEMO protein.	Asparagine	136-146	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	200-204
18322210-3	2008	In this study, three conserved glycans (linked to N406, N448, and N463) flanking the C4 region of gp120 that contains many known CD4 T cell epitopes were disrupted individually or in combination by asparagine-to-glutamine substitutions.	Asparagine	198-208	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	98-103
18322210-3	2008	In this study, three conserved glycans (linked to N406, N448, and N463) flanking the C4 region of gp120 that contains many known CD4 T cell epitopes were disrupted individually or in combination by asparagine-to-glutamine substitutions.	Asparagine	198-208	CD4 molecule	Homo sapiens	129-132
18006672-5	2008	RESULTS: Screening of the GJA8 gene identified a 139 G to A transition that resulted in the replacement of aspartic acid by asparagine (D47N) in the coding region of Cx50.	Asparagine	124-134	gap junction protein alpha 8	Homo sapiens	26-30
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Asparagine	82-92	Cbl proto-oncogene	Homo sapiens	199-204
18247577-7	2008	Among eight other mutations of His51 in hSVCT1, significant sodium-dependent ascorbate transport activity was only observed with asparagine or tyrosine replacement.	Asparagine	129-139	solute carrier family 23 member 1	Homo sapiens	40-46
18349268-7	2008	Subtle but significant cancer risk was observed for the XPD Asp 312 Asn polymorphism in bladder cancer (for Asp/Asn versus Asp/Asp: OR, 1.24; 95% CI, 1.06-1.46).	Asparagine	68-71	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	56-59
18393921-5	2008	However, as a consequence of reading-frame shifts due to nt insertions/deletions, the protein products generated may differ considerably from the prototypal HRB protein, which comprises one Arf-GAP zinc finger domain, several Phenylalanine-Glycine (FG) motifs and four Asparagine-Proline-Phenylalanine (NPF) motifs.	Asparagine	269-279	ArfGAP with FG repeats 1	Homo sapiens	157-160
18006672-5	2008	RESULTS: Screening of the GJA8 gene identified a 139 G to A transition that resulted in the replacement of aspartic acid by asparagine (D47N) in the coding region of Cx50.	Asparagine	124-134	gap junction protein alpha 8	Homo sapiens	166-170
18067928-2	2008	In the present study, genotype and haplotype frequencies of four single nucleotide polymorphisms (SNPs) in CYP1B1 that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at codon 432 and Asn-Ser at codon 453) were studied in 150 cases suffering from head and neck squamous cell carcinoma (HNSCC) and in an equal number of controls.	Asparagine	213-216	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
17701959-0	2008	Dimerization of a PACAP peptide analogue in DMSO via asparagine and aspartic acid residues.	Asparagine	53-63	adenylate cyclase activating polypeptide 1	Homo sapiens	18-23
18301339-2	2008	Single nucleotide polymorphisms of PECAM-1 encoding amino acid substitutions at positions 98 leucine/valine (L/V), 536 serine/asparagine (S/N), and 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR and VNG).	Asparagine	126-136	platelet and endothelial cell adhesion molecule 1	Homo sapiens	35-42
18299291-6	2008	We mutated five of the asparagine side chains in IAPP and assessed their effects on the kinetics of assembly.	Asparagine	23-33	islet amyloid polypeptide	Homo sapiens	49-53
18299291-7	2008	We find that the asparagine amide side chains strongly dictate the ability of IAPP to form fibers.	Asparagine	17-27	islet amyloid polypeptide	Homo sapiens	78-82
18079109-5	2008	The UBA domain of CIP75 is the main element mediating the interaction with Cx43, whereas the CIP75-interacting region in Cx43 resides in the PY motif and multiphosphorylation sites located between Lys 264 and Asn 302.	Asparagine	209-212	ubiquilin 4	Homo sapiens	93-98
18079109-5	2008	The UBA domain of CIP75 is the main element mediating the interaction with Cx43, whereas the CIP75-interacting region in Cx43 resides in the PY motif and multiphosphorylation sites located between Lys 264 and Asn 302.	Asparagine	209-212	gap junction protein alpha 1	Homo sapiens	121-125
18057002-9	2008	Two of the four predicted glycosylation sites, asparagines 132 and 263, are actually involved in N-linked glycosylation, resulting in heterogeneity in CD14 molecular weight.	Asparagine	47-58	CD14 molecule	Homo sapiens	151-155
18057002-10	2008	Furthermore, glycosylation at Asn(132) plays a role in CD14 trafficking and upstream and/or downstream ligand interactions.	Asparagine	30-33	CD14 molecule	Homo sapiens	55-59
18057002-11	2008	When mapped onto the crystal structure of mouse CD14, the first two disulfide bonds and Asn(132) are in close proximity to the initial beta strands of the leucine rich repeat domain.	Asparagine	88-91	CD14 antigen	Mus musculus	48-52
18247306-6	2008	An additional G--&gt;T transvertion at nucleotide 139 (c.139G&gt;T) in exon 2 of GJA8, resulting in a missense mutation of asparagines (GAU) to tyrosine (UAU) at codon 47 (D47Y).	Asparagine	123-134	gap junction protein alpha 8	Homo sapiens	81-85
18177001-6	2008	Moreover, we have identified an asparagine residue in the hH1R protein that is subject to N-linked glycosylation.	Asparagine	32-42	histamine receptor H1	Homo sapiens	58-62
18162597-3	2008	Previous studies of Arabidopsis thaliana root cells showed that the amino acids alanine (Ala), asparagine (Asn), cysteine (Cys), Glu, glycine (Gly), and serine trigger transient Ca(2+) influx and membrane depolarization by a mechanism that depends on the GLR3.3 gene.	Asparagine	95-105	glutamate receptor 3.3	Arabidopsis thaliana	255-261
18237398-0	2008	The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion.	Asparagine	20-30	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	44-49
18235976-0	2008	N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway.	Asparagine	19-22	cadherin 1	Homo sapiens	47-57
18235976-2	2008	The ectodomain of human E-cadherin contains four potential N-glycosylation sites at Asn residues 554, 566, 618, and 633.	Asparagine	84-87	cadherin 1	Homo sapiens	24-34
17725604-2	2008	CD1d1 is predicted to contain five potential N-linked glycosylation sites (asparagine residues at positions 25, 38, 60, 128, and 183).	Asparagine	75-85	CD1d1 antigen	Mus musculus	0-5
17725604-3	2008	Glycosylation has been shown to invariably affect the molecular and functional properties of various glycoproteins, and in the current report it was found that a conservative change of the individual endogenous asparagine residues in CD1d1 to glutamine differentially affected its functional expression.	Asparagine	211-221	CD1d1 antigen	Mus musculus	234-239
17938953-4	2008	Phosphorylation of ARR7 is inhibited in vitro by mutation in a putative phospho-accepting Asp residue into an Asn residue (ARR7(D85N)).	Asparagine	110-113	response regulator 7	Arabidopsis thaliana	19-23
17938953-4	2008	Phosphorylation of ARR7 is inhibited in vitro by mutation in a putative phospho-accepting Asp residue into an Asn residue (ARR7(D85N)).	Asparagine	110-113	response regulator 7	Arabidopsis thaliana	123-127
18237438-6	2008	Crystal structures reveal that, in TRalpha Arg228 is observed in multiple conformations, an effect triggered by the differences in the interactions between GC-1 and Ser277 or the corresponding asparagine (Asn331) of TRbeta.	Asparagine	193-203	thyroid hormone receptor beta	Rattus norvegicus	216-222
18046457-2	2008	Oligosaccharyltransferase (OST) catalyzes the co-translational transfer of an oligosaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains.	Asparagine	119-129	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
18046457-2	2008	Oligosaccharyltransferase (OST) catalyzes the co-translational transfer of an oligosaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains.	Asparagine	119-129	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
18235846-10	2008	Comparative modeling of the three-dimensional structure of E. histolytica putative ODC shows that the putative binding site for DFMO is disrupted by the substitution of three amino acids-aspartate-332, aspartate-361, and tyrosine-323-by histidine-296, phenylalanine-305, and asparagine-334, through which this inhibitor interacts with the protein.	Asparagine	275-285	ornithine decarboxylase 1	Homo sapiens	83-86
18179707-5	2008	We use site-directed mutagenesis to demonstrate that the difference between FAX-1 and NHR-67 binding preference is partially mediated by a conserved subclass-specific asparagine or aspartate residue at position 19 of the DNA-binding domain.	Asparagine	167-177	Nuclear hormone receptor family member fax-1	Caenorhabditis elegans	76-81
18179707-5	2008	We use site-directed mutagenesis to demonstrate that the difference between FAX-1 and NHR-67 binding preference is partially mediated by a conserved subclass-specific asparagine or aspartate residue at position 19 of the DNA-binding domain.	Asparagine	167-177	Nuclear hormone receptor family member nhr-67	Caenorhabditis elegans	86-92
17705787-0	2007	The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.	Asparagine	152-162	nuclear respiratory factor 1	Homo sapiens	70-74
18473246-0	2008	Hb Jeddah [alpha68(E17)Asn-->His (alpha1)]: a newly recognized alpha chain variant, seen in combination with Hb S [beta6(A3)Glu-->Val], and found in three separate families of middle eastern origin.	Asparagine	23-26	BCL2 related protein A1	Homo sapiens	34-40
18097551-1	2008	N-acetylglucosaminyltransferase-V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagines (N)-linked oligosaccharides of cell proteins.	Asparagine	114-125	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-33
18097551-1	2008	N-acetylglucosaminyltransferase-V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagines (N)-linked oligosaccharides of cell proteins.	Asparagine	114-125	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	35-40
18097551-1	2008	N-acetylglucosaminyltransferase-V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagines (N)-linked oligosaccharides of cell proteins.	Asparagine	114-125	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	70-77
18054050-12	2008	Hung, Alterations in the domain structure of tissue-type plasminogen activator change the nature of asparagine glycosylation.	Asparagine	100-110	plasminogen activator, tissue type	Homo sapiens	45-78
17885205-2	2008	We characterized the C terminus-binding site of VIP in the N-terminal ectodomain (N-ted) of the human VPAC1 receptor: 1) The probe [(125)I-Bpa(28)]VIP in which the C-terminal residue (Asn(28)) is substituted by a photoreactive p-benzoyl-l-Phe (Bpa) was used to photolabel the receptor.	Asparagine	184-187	vasoactive intestinal peptide	Homo sapiens	48-51
17885205-3	2008	After receptor cleavage and Edman sequencing, it was shown that Asn(28) of VIP is in contact with Lys(127) in the receptor N-ted.	Asparagine	64-67	vasoactive intestinal peptide	Homo sapiens	75-78
18076756-5	2007	We have recently generated a mouse model carrying an activated PDGFR-beta by replacing the highly conserved aspartic acid residue (D) 849 in the activating loop with asparagine (N).	Asparagine	166-176	platelet derived growth factor receptor, beta polypeptide	Mus musculus	63-73
18076768-0	2007	Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.	Asparagine	0-3	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	11-16
18076768-0	2007	Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.	Asparagine	0-3	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	79-100
18076768-4	2007	Sequence analysis identified the presence of Asn 362 (N362), a potential N-linked glycosylation site immediately N-terminal to CD4-binding site (CD4bs) residues in the C3 region of gp120, more frequently in A-R5 Envs than PA-R5 Envs.	Asparagine	45-48	CD4 molecule	Homo sapiens	127-130
18076768-4	2007	Sequence analysis identified the presence of Asn 362 (N362), a potential N-linked glycosylation site immediately N-terminal to CD4-binding site (CD4bs) residues in the C3 region of gp120, more frequently in A-R5 Envs than PA-R5 Envs.	Asparagine	45-48	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	181-186
17572430-1	2008	We previously identified a G&gt;A single nucleotide polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product.	Asparagine	242-252	vascular cell adhesion molecule 1	Mus musculus	166-171
18039857-2	2008	A novel regulatory mechanism to control c-Src function that has recently been identified involves the C-terminal amino acid sequence Gly-Glu-Asn-Leu (GENL) of c-Src as ligand for PDZ domains.	Asparagine	141-144	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
18039857-2	2008	A novel regulatory mechanism to control c-Src function that has recently been identified involves the C-terminal amino acid sequence Gly-Glu-Asn-Leu (GENL) of c-Src as ligand for PDZ domains.	Asparagine	141-144	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	159-164
17959710-0	2008	Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors.	Asparagine	91-101	histamine receptor H1	Homo sapiens	37-58
17959710-3	2008	The highly conserved hydrophobic amino acid at position 6.40 defines, in a computational model of the H(1)R, the asparagine cage motif that restrains the side chain of Asn7.49 of the NPxxY motif toward transmembrane domain (TM 6) in the inactive state of the receptor.	Asparagine	113-123	histamine receptor H1	Homo sapiens	102-107
17854853-5	2007	Kinetics studies showed that ABU-LAO is very active towards its substrates L-Asn, L-Phe, L-Tyr, L-Leu, L-Ile and L-Trp.	Asparagine	75-80	interleukin 4 induced 1	Homo sapiens	33-36
17705787-11	2007	Wild-type Nrf1 is glycosylated through its Asn/Ser/Thr-rich domain, between amino acids 296 and 403, and this modification was not observed in an Nrf1(Delta299-400) mutant.	Asparagine	43-46	nuclear respiratory factor 1	Homo sapiens	10-14
17967520-4	2007	The mutation is a single T to A base substitution in exon 10 of Otof that causes a non-conservative amino acid change of isoleucine to asparagine in the C2B domain of the protein.	Asparagine	135-145	otoferlin	Mus musculus	64-68
20641675-11	2004	A synthetic peptide (Arg-Glu-Asn-Leu-Arg-Ile-Ala-Leu-Arg-Tyr, B2702-p) corresponding to residues 75-84 of HLA-B2702 was shown to bind specifically to VCAM-1 (9).	Asparagine	29-32	major histocompatibility complex, class I, B	Homo sapiens	106-111
18067083-10	2007	In the third family, the sequencing of the CYP21 gene of two patients revealed a homozygous T to A transition in codon 172 leading to substitution of isoleucine by asparagine (I172N).	Asparagine	164-174	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	43-48
17953455-1	2007	Residues 1-89 constitute the Asn- and Gln-rich segment of the Ure2p protein and produce the [URE3] prion of Saccharomyces cerevisiae by forming the core of intracellular Ure2p amyloid.	Asparagine	29-32	glutathione peroxidase	Saccharomyces cerevisiae S288C	62-67
17939663-2	2007	In the complex formed between morphinone reductase (MR) and the NADH analogue 1,4,5,6-tetrahydro-NADH (NADH4) the nicotinamide moiety is restrained close to the FMN isoalloxazine ring by hydrogen bonds from Asn-189 and His-186 as determined from the X-ray crystal structure.	Asparagine	207-210	formin 1	Homo sapiens	161-164
17953455-1	2007	Residues 1-89 constitute the Asn- and Gln-rich segment of the Ure2p protein and produce the [URE3] prion of Saccharomyces cerevisiae by forming the core of intracellular Ure2p amyloid.	Asparagine	29-32	glutathione peroxidase	Saccharomyces cerevisiae S288C	170-175
17984320-0	2007	Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae.	Asparagine	22-32	U6 snRNA complex subunit LSM4	Saccharomyces cerevisiae S288C	48-53
17980170-11	2007	We next determined N-glycosylation sites of human NAAA by site-directed mutagenesis addressed to asparagine residues in six potential N-glycosylation sites.	Asparagine	97-107	N-acylethanolamine acid amidase	Homo sapiens	50-54
17715132-5	2007	We show for the first time that Pannexin1 is glycosylated at Asn-254 and that this residue is important for plasma membrane targeting.	Asparagine	61-64	pannexin 1	Homo sapiens	32-41
17728165-3	2007	This predicted binding site is located within transmembrane helical domains (TMs) 3, 4, 5 and 6, with Asn residues in TM3 and TM4 identified as the key residues for adenine binding.	Asparagine	102-105	tropomyosin 4	Rattus norvegicus	126-129
17715238-0	2007	Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry.	Asparagine	9-19	CD209 molecule	Homo sapiens	64-71
17715238-0	2007	Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry.	Asparagine	9-19	C-type lectin domain family 4 member M	Homo sapiens	77-83
17964262-3	2007	A nondiscriminating aspartyl-tRNA synthetase (ND-DRS) first generates a mischarged aspartyl-tRNAAsn that dissociates from the enzyme and binds to a tRNA-dependent amidotransferase (AdT), which then converts the tRNA-bound aspartate into asparagine.	Asparagine	237-247	sushi repeat containing protein X-linked	Homo sapiens	49-52
17699514-7	2007	Moreover, a single point mutation in the first extracellular loop domain of claudin-3 to convert Asn(44) to the corresponding amino acid in claudin-4 (Thr) produced a claudin capable of heterotypic binding to claudin-4 while still retaining the ability to bind to claudin-1 and -5.	Asparagine	97-100	claudin 3	Homo sapiens	76-85
17940047-2	2007	Recently, to elucidate the oligomerization pathway, we studied Abeta monomer folding and identified a decapeptide segment of Abeta, (21)Ala-(22)Glu-(23)Asp-(24)Val-(25)Gly-(26)Ser-(27)Asn-(28)Lys-(29)Gly-(30)Ala, within which turn formation appears to nucleate monomer folding.	Asparagine	184-187	amyloid beta precursor protein	Homo sapiens	125-130
17960739-4	2007	After immunoprecipitation, CD9P-1 was subjected to enzymatic PNGase F cleavage of N-glycans, resulting in Asn to Asp conversion and increase in 1 mass unit.	Asparagine	106-109	prostaglandin F2 receptor inhibitor	Homo sapiens	27-33
17699514-7	2007	Moreover, a single point mutation in the first extracellular loop domain of claudin-3 to convert Asn(44) to the corresponding amino acid in claudin-4 (Thr) produced a claudin capable of heterotypic binding to claudin-4 while still retaining the ability to bind to claudin-1 and -5.	Asparagine	97-100	claudin 4	Homo sapiens	140-149
17699514-7	2007	Moreover, a single point mutation in the first extracellular loop domain of claudin-3 to convert Asn(44) to the corresponding amino acid in claudin-4 (Thr) produced a claudin capable of heterotypic binding to claudin-4 while still retaining the ability to bind to claudin-1 and -5.	Asparagine	97-100	claudin 4	Homo sapiens	209-218
17699514-7	2007	Moreover, a single point mutation in the first extracellular loop domain of claudin-3 to convert Asn(44) to the corresponding amino acid in claudin-4 (Thr) produced a claudin capable of heterotypic binding to claudin-4 while still retaining the ability to bind to claudin-1 and -5.	Asparagine	97-100	claudin 1	Homo sapiens	264-280
17680815-2	2007	Hb Stanleyville II is characterized by a single base exchange (AAC--&gt;AAA) resulting in a substitution Asn --&gt; Lys at position 78 of hemoglobin alpha2-chain.	Asparagine	105-108	glycine-N-acyltransferase	Homo sapiens	63-66
17889671-4	2007	We show that the MUC1 C-terminal subunit is glycosylated on Asn-36 and that this modification is necessary for upregulation of galectin-3.	Asparagine	60-63	mucin 1, cell surface associated	Homo sapiens	17-21
17621593-4	2007	Recombinant hITLN-1 is a trimer, disulfide-linked through Cys-31 and Cys-48, and N-glycosylated at Asn-163.	Asparagine	99-102	intelectin 1	Homo sapiens	12-19
17767554-2	2007	Compared with HLA-B*530101, there is one silent substitution at nucleotide 438 and two non-synonymous substitutions at nucleotides 431 and 440, causing a change of the amino acid sequence (Asn--&gt;Ser at codon 77 and Ile--&gt;Thr at codon 80, respectively) within the Bw4 epitope.	Asparagine	189-192	major histocompatibility complex, class I, B	Homo sapiens	14-19
17892495-1	2007	Spontaneous protein deamidation of labile Asn residues, generating L-isoaspartates and D-aspartates, is associated with cell aging and is enhanced by an oxidative microenvironment; to minimize the damage, the isoaspartate residues can be "repaired" by a specific L-isoaspartate (D-aspartate) protein O-methyltransferase (PIMT).	Asparagine	42-45	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	321-325
17889671-6	2007	The results show that, in turn, galectin-3 binds to MUC1-C at the glycosylated Asn-36 site.	Asparagine	79-82	galectin 3	Homo sapiens	32-42
17889671-6	2007	The results show that, in turn, galectin-3 binds to MUC1-C at the glycosylated Asn-36 site.	Asparagine	79-82	mucin 1, cell surface associated	Homo sapiens	52-56
17696499-7	2007	The isolated PDE11 catalytic domain (Met-563-Asn-934) displayed both monomeric and dimeric forms, and upon dilution, this domain was primarily monomeric, indicating that the main oligomerization contacts are within the N-termini of PDE isozymes.	Asparagine	45-48	phosphodiesterase 11A	Homo sapiens	13-18
17636259-6	2007	We mutated Arg(47) of the Sdh3p subunit to Cys, Glu, and Lys and Asp(88) of the Sdh4p subunit to Asn, Glu, and Lys.	Asparagine	97-100	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	80-85
17696499-7	2007	The isolated PDE11 catalytic domain (Met-563-Asn-934) displayed both monomeric and dimeric forms, and upon dilution, this domain was primarily monomeric, indicating that the main oligomerization contacts are within the N-termini of PDE isozymes.	Asparagine	45-48	phosphodiesterase 11A	Homo sapiens	13-16
17545692-4	2007	Site-directed mutants of EL were generated by replacing asparagine (N) 62, 118, 375, and 473 with alanine (A).	Asparagine	56-66	lipase G, endothelial type	Homo sapiens	25-27
17693144-4	2007	In PinA, a fungal homologue of Pin1, the arginine residue (R17) is replaced with an asparagine residue (N17).	Asparagine	84-94	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
17483910-7	2007	The individual mutation of Arg(36), Asn (39), and Gln(40) resulted in a reduction in the catalytic activity of EDN on poly(U) and poly(C).	Asparagine	36-39	ribonuclease A family member 2	Homo sapiens	111-114
17681230-7	2007	rHlLgm degraded bovine hemoglobin and bovine serum albumin (BSA) showing its strict specificity for hydrolysis of the peptide on the carboxyl side of the asparagines, as demonstrated by internal amino acid sequence analysis of proteolytic product of BSA cleavage.	Asparagine	154-165	albumin	Bos taurus	45-58
17584745-3	2007	This screen identified amino acids Gln-419 and Asn-425 as being important for the interaction between Gpa2p and Krh1p.	Asparagine	47-50	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	102-107
17850748-3	2007	Here, we present an X-ray crystal structure of the tandem KH domains of human FMRP, which reveals the relative orientation of the KH1 and KH2 domains and the location of residue Ile304, whose mutation to Asn is associated with a particularly severe incidence of Fragile X syndrome.	Asparagine	204-207	fragile X messenger ribonucleoprotein 1	Homo sapiens	78-82
17584745-3	2007	This screen identified amino acids Gln-419 and Asn-425 as being important for the interaction between Gpa2p and Krh1p.	Asparagine	47-50	Gpb2p	Saccharomyces cerevisiae S288C	112-117
17584745-7	2007	Residues Gln-419 and Asn-425 are located in the beta6-alpha5 loop and alpha5 helix of Gpa2p, which is the region that couples receptor binding to guanine nucleotide exchange.	Asparagine	21-24	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	86-91
17668005-5	2007	Direct binding of unassembled Pen2 to Rer1 is mediated by the first transmembrane domain of Pen2, and a conserved asparagine in this domain is required.	Asparagine	114-124	presenilin enhancer, gamma-secretase subunit	Homo sapiens	30-34
17668005-5	2007	Direct binding of unassembled Pen2 to Rer1 is mediated by the first transmembrane domain of Pen2, and a conserved asparagine in this domain is required.	Asparagine	114-124	retention in endoplasmic reticulum sorting receptor 1	Homo sapiens	38-42
17617795-4	2007	The wild type sequence of PTH(1-11) is H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-NH(2).	Asparagine	77-80	parathyroid hormone	Homo sapiens	26-29
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Asparagine	188-191	major histocompatibility complex, class II, DR beta 1	Homo sapiens	23-27
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Asparagine	188-191	major histocompatibility complex, class II, DR beta 1	Homo sapiens	57-61
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Asparagine	188-191	glycine-N-acyltransferase	Homo sapiens	129-132
17591922-7	2007	Matrix assembly assays and solid-phase binding assays reveal that alphavbeta3 integrin assembles FN-RGE by binding an isoDGR motif in FN-I5, which is generated by the nonenzymatic rearrangement of asparagines (N) into an iso-aspartate (iso-D).	Asparagine	197-208	fibronectin 1	Mus musculus	97-99
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Asparagine	173-176	major intrinsic protein of lens fiber	Homo sapiens	74-78
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Asparagine	173-176	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Asparagine	173-176	aquaporin 4	Homo sapiens	86-90
17591922-7	2007	Matrix assembly assays and solid-phase binding assays reveal that alphavbeta3 integrin assembles FN-RGE by binding an isoDGR motif in FN-I5, which is generated by the nonenzymatic rearrangement of asparagines (N) into an iso-aspartate (iso-D).	Asparagine	197-208	fibronectin 1	Mus musculus	134-136
17559584-2	2007	This allele is identical to the HLA-B*3308 allele except for one point mutation in exon 2 at codon 66 (AAA--&gt;AAT), resulting in an amino acid change from lysine (K) to asparagine (N).	Asparagine	171-181	major histocompatibility complex, class I, B	Homo sapiens	32-37
18428410-2	2007	Trf is an N-glycosylated protein with two asparagine glycation sites.	Asparagine	42-52	transferrin	Homo sapiens	0-3
17499207-12	2007	The Asp380 amino acid residue appears to be important in myocilin function based on the finding that substitution of this amino acid with four different amino acids (His, Ala, Asn, or Gly) all result in a similar presentation of POAG that is intermediate between the more severe clinical presentations observed in individuals with the Pro370Leu or Lys423Glu variant and the milder findings in patients with the Gln368Stop mutation.	Asparagine	176-179	myocilin	Homo sapiens	57-65
17559584-2	2007	This allele is identical to the HLA-B*3308 allele except for one point mutation in exon 2 at codon 66 (AAA--&gt;AAT), resulting in an amino acid change from lysine (K) to asparagine (N).	Asparagine	171-181	serpin family A member 1	Homo sapiens	112-115
17563389-1	2007	The neurokinin 1 receptor (NK1R), a G protein-coupled receptor involved in diverse functions including pain and inflammation, has two putative N-linked glycosylation sites, Asn-14 and Asn-18.	Asparagine	173-176	tachykinin receptor 1	Homo sapiens	4-25
17646702-1	2007	L-asparaginase (EC 3.5.1.1) catalyzes the hydrolysis of the amide group of L-asparagine, releasing aspartate and NH4+.	Asparagine	75-87	L-asparaginase	Glycine max	0-14
17471479-3	2007	Using intramolecularly quenched fluorogenic (IQF) peptides based on hSARS-CoV spike protein (Abz-(755)Glu-Gln-Asp-Arg-Asn-Thr-Arg-Glu-Val-Phe-Ala-Gln(766)-Tyx-NH(2)) and in vitro studies, we show that besides furin, other PCs, like PC5 and PC7, might also be involved in this cleavage event.	Asparagine	118-121	furin, paired basic amino acid cleaving enzyme	Homo sapiens	209-214
17594508-8	2007	The bases for its selectivity and potency were assessed on a notable interaction between the substrate Asn (N) and the caspase-3 residue Ser209 in the S3 subsite and the tight interaction between the substrate Leu (L) and the caspase-3 hydrophobic S2 subsite, respectively, in computational docking studies.	Asparagine	103-106	caspase 3	Homo sapiens	119-128
17594508-8	2007	The bases for its selectivity and potency were assessed on a notable interaction between the substrate Asn (N) and the caspase-3 residue Ser209 in the S3 subsite and the tight interaction between the substrate Leu (L) and the caspase-3 hydrophobic S2 subsite, respectively, in computational docking studies.	Asparagine	103-106	caspase 3	Homo sapiens	226-235
17563389-1	2007	The neurokinin 1 receptor (NK1R), a G protein-coupled receptor involved in diverse functions including pain and inflammation, has two putative N-linked glycosylation sites, Asn-14 and Asn-18.	Asparagine	173-176	tachykinin receptor 1	Homo sapiens	27-31
17471479-3	2007	Using intramolecularly quenched fluorogenic (IQF) peptides based on hSARS-CoV spike protein (Abz-(755)Glu-Gln-Asp-Arg-Asn-Thr-Arg-Glu-Val-Phe-Ala-Gln(766)-Tyx-NH(2)) and in vitro studies, we show that besides furin, other PCs, like PC5 and PC7, might also be involved in this cleavage event.	Asparagine	118-121	proprotein convertase subtilisin/kexin type 5	Homo sapiens	232-235
17471479-3	2007	Using intramolecularly quenched fluorogenic (IQF) peptides based on hSARS-CoV spike protein (Abz-(755)Glu-Gln-Asp-Arg-Asn-Thr-Arg-Glu-Val-Phe-Ala-Gln(766)-Tyx-NH(2)) and in vitro studies, we show that besides furin, other PCs, like PC5 and PC7, might also be involved in this cleavage event.	Asparagine	118-121	proprotein convertase subtilisin/kexin type 7	Homo sapiens	240-243
17563389-1	2007	The neurokinin 1 receptor (NK1R), a G protein-coupled receptor involved in diverse functions including pain and inflammation, has two putative N-linked glycosylation sites, Asn-14 and Asn-18.	Asparagine	184-187	tachykinin receptor 1	Homo sapiens	4-25
17563389-1	2007	The neurokinin 1 receptor (NK1R), a G protein-coupled receptor involved in diverse functions including pain and inflammation, has two putative N-linked glycosylation sites, Asn-14 and Asn-18.	Asparagine	184-187	tachykinin receptor 1	Homo sapiens	27-31
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Asparagine	84-94	Cbl proto-oncogene	Homo sapiens	193-219
17426026-6	2007	Ran binding was mediated by a three-amino acid motif (Leu(13)/Val(14)/Asn(25)) located within the two zinc coordination loops.	Asparagine	70-73	RAN, member RAS oncogene family	Homo sapiens	0-3
17489562-0	2007	Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2).	Asparagine	26-36	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	107-116
17544358-3	2007	Two common single nucleotide polymorphisms (SNP) within exon 10 of the human FSHR gene result in two almost equally common allelic variants exhibiting threonine (Thr) or alanine (Ala) at position 307 in the hinge region, respectively, asparagine (Asn) or serine (Ser) at codon 680 of the intracellular domain.	Asparagine	235-245	follicle stimulating hormone receptor	Homo sapiens	77-81
17544358-3	2007	Two common single nucleotide polymorphisms (SNP) within exon 10 of the human FSHR gene result in two almost equally common allelic variants exhibiting threonine (Thr) or alanine (Ala) at position 307 in the hinge region, respectively, asparagine (Asn) or serine (Ser) at codon 680 of the intracellular domain.	Asparagine	247-250	follicle stimulating hormone receptor	Homo sapiens	77-81
17487431-7	2007	Only 2 of 8 Asn-linked glycosylation sites in primate CD133 orthologs were conserved in rodent CD133 orthologs.	Asparagine	12-15	prominin 1	Homo sapiens	54-59
17508782-5	2007	In particular, the register of these amino acids holds Asn-25 that is critical for the virus binding with primary cell receptor CD4 as well as Arg-3 that is critical for utilization of CCR5 co-receptor and heparan sulfate proteoglycans.	Asparagine	55-58	CD4 molecule	Homo sapiens	128-131
17293345-5	2007	In human embryonic kidney 293 cells, Orai1 is glycosylated at an asparagine residue in the predicted second extracellular loop, but mutation of the residue does not compromise function.	Asparagine	65-75	ORAI calcium release-activated calcium modulator 1	Homo sapiens	37-42
17403680-6	2007	Substitution of Ala for Asn residues within each of three consensus N-linked glycosylation sites in the propeptide abrogated ADAMTS9 secretion.	Asparagine	24-27	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	125-132
17508782-5	2007	In particular, the register of these amino acids holds Asn-25 that is critical for the virus binding with primary cell receptor CD4 as well as Arg-3 that is critical for utilization of CCR5 co-receptor and heparan sulfate proteoglycans.	Asparagine	55-58	C-C motif chemokine receptor 5	Homo sapiens	185-189
17272393-9	2007	It is concluded that glycosylation of Asn(302) of the alpha-subunit of inhibin A and B results in a decrease in bioactivity, and the effect on inhibin A, at least, is explained by its reduced affinity to betaglycan.	Asparagine	38-41	transforming growth factor beta receptor 3	Homo sapiens	204-214
17535882-9	2007	Despite substitution of asparagine with proline in the NHX(4)D motif and arginine with cysteine in the EGTR motif, AGPAT9 retains AGPAT activity suggesting that residues asparagine and arginine in the NHX(4)D and EGTR motifs respectively are not essential for the enzymatic activity.	Asparagine	170-180	glycerol-3-phosphate acyltransferase 3	Homo sapiens	115-121
17379602-7	2007	A helical wheel projection of TM 8 predicted that Phe-334 and Asn-338 lie in close proximity to other highly conserved and/or hydrophilic residues, suggesting that they form part of a structurally important region that influences interactions with inhibitors, protein folding, and rates of conformational change during the transport cycle.	Asparagine	62-65	tetraspanin 16	Homo sapiens	30-34
17439157-2	2007	Central to this pathway is PglB, a homologue of the Stt3p subunit of the eukaryotic oligosaccharyl transferase (OT), which is involved in the transfer of an oligosaccharide from a polyisoprenyl pyrophosphate carrier to the asparagine side chain of proteins within the conserved glycosylation sites D/E-X1-N-X2-S/T, where X1 and X2 can be any amino acids except proline.	Asparagine	223-233	epiphycan	Homo sapiens	27-31
17369259-4	2007	Systematic shuffling of the 20 amino acid residues that differ between Hxt2 and Hxt1 in these TMs subsequently identified 5 residues as important for such activity: Leu(59) and Leu(61) (TM1), Leu(201) (TM5), Asn(331) (TM7), and Phe(366) (TM8).	Asparagine	208-211	hexose transporter HXT2	Saccharomyces cerevisiae S288C	71-75
17369259-4	2007	Systematic shuffling of the 20 amino acid residues that differ between Hxt2 and Hxt1 in these TMs subsequently identified 5 residues as important for such activity: Leu(59) and Leu(61) (TM1), Leu(201) (TM5), Asn(331) (TM7), and Phe(366) (TM8).	Asparagine	208-211	hexose transporter HXT1	Saccharomyces cerevisiae S288C	80-84
17261584-5	2007	In addition, two buried asparagines at a positions 19 and 33 in the HY5 LZ domain display distinct modes of polar interaction.	Asparagine	24-35	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	68-71
17322565-1	2007	We previously identified that four of five putative N-linked glycosylation sites of human endothelial lipase (EL) are utilized and suggested that the substitution of asparagine-116 (Asn-116) with alanine (Ala) (N116A) increased the hydrolytic activity of EL.	Asparagine	166-176	lipase G, endothelial type	Homo sapiens	90-108
17322565-1	2007	We previously identified that four of five putative N-linked glycosylation sites of human endothelial lipase (EL) are utilized and suggested that the substitution of asparagine-116 (Asn-116) with alanine (Ala) (N116A) increased the hydrolytic activity of EL.	Asparagine	166-176	lipase G, endothelial type	Homo sapiens	110-112
17322565-1	2007	We previously identified that four of five putative N-linked glycosylation sites of human endothelial lipase (EL) are utilized and suggested that the substitution of asparagine-116 (Asn-116) with alanine (Ala) (N116A) increased the hydrolytic activity of EL.	Asparagine	166-176	lipase G, endothelial type	Homo sapiens	255-257
17322565-8	2007	These data suggest that N-linked glycosylation at Asn-116 reduces the ability of EL to hydrolyze lipids in LDL and HDL2.	Asparagine	50-53	lipase G, endothelial type	Homo sapiens	81-83
17322565-8	2007	These data suggest that N-linked glycosylation at Asn-116 reduces the ability of EL to hydrolyze lipids in LDL and HDL2.	Asparagine	50-53	junctophilin 3	Homo sapiens	115-119
17390031-9	2007	Comparative proteomics revealed that N-terminal signal peptide, 22 Cys residues, two Asn-linked glycosylation sites, Gly230, and Arg284 of human WNT8B were conserved among mammalian WNT8B orthologs.	Asparagine	85-88	Wnt family member 8B	Homo sapiens	145-150
17382325-4	2007	The results demonstrated that asparagine hydroxylation and S-nitrosylation of HIF-1alpha decrease p300 binding, while its phosphorylation does not affect p300 binding, which was reconfirmed by competitive inhibition analyses using mutant peptides.	Asparagine	30-40	E1A binding protein p300	Homo sapiens	98-102
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Asparagine	57-67	sex hormone binding globulin	Homo sapiens	161-165
17300802-2	2007	Moreover, Rap1GAP, which stimulates the GTPase reaction of Rap1 10(5)-fold, does not have the classical "arginine finger" like RasGAP but presumably, introduces an asparagine residue into the active site.	Asparagine	164-174	RAP1 GTPase activating protein	Homo sapiens	10-17
17300802-2	2007	Moreover, Rap1GAP, which stimulates the GTPase reaction of Rap1 10(5)-fold, does not have the classical "arginine finger" like RasGAP but presumably, introduces an asparagine residue into the active site.	Asparagine	164-174	RAP1A, member of RAS oncogene family	Homo sapiens	10-14
17307740-1	2007	Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is N-glycosylated on Asn-53, Asn-410, and Asn-524.	Asparagine	97-100	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	70-74
17307740-1	2007	Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is N-glycosylated on Asn-53, Asn-410, and Asn-524.	Asparagine	105-108	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	70-74
17307740-1	2007	Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is N-glycosylated on Asn-53, Asn-410, and Asn-524.	Asparagine	105-108	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	70-74
17307740-2	2007	Mutagenesis and deglycosylation experiments revealed that only the glycosylation of Asn-524 is essential for the expression of the catalytic and motility-stimulating activities of NPP2.	Asparagine	84-87	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	180-184
17307740-5	2007	Consistent with a structural role for the Asn-524-linked glycan, only the mutation of Asn-524 augmented the sensitivity of NPP2 to proteolysis and increased its mobility during Blue Native PAGE.	Asparagine	42-45	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	123-127
17307740-5	2007	Consistent with a structural role for the Asn-524-linked glycan, only the mutation of Asn-524 augmented the sensitivity of NPP2 to proteolysis and increased its mobility during Blue Native PAGE.	Asparagine	86-89	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	123-127
17307740-6	2007	Asn-524 is phylogenetically conserved and maps to the catalytic domain of NPP2, but a structural model of this domain suggests that Asn-524 is remote from the catalytic site.	Asparagine	0-3	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	74-78
17307740-6	2007	Asn-524 is phylogenetically conserved and maps to the catalytic domain of NPP2, but a structural model of this domain suggests that Asn-524 is remote from the catalytic site.	Asparagine	132-135	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	74-78
17307740-7	2007	Our study defines an essential role for the Asn-524-linked glycan chain of NPP2.	Asparagine	44-47	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	75-79
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Asparagine	87-97	endothelin 1	Homo sapiens	124-136
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Asparagine	87-97	endothelin 1	Homo sapiens	138-142
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Asparagine	87-97	lecithin-cholesterol acyltransferase	Homo sapiens	231-268
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Asparagine	87-97	lecithin-cholesterol acyltransferase	Homo sapiens	270-274
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Asparagine	57-67	sex hormone binding globulin	Homo sapiens	276-280
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Asparagine	69-72	sex hormone binding globulin	Homo sapiens	161-165
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Asparagine	93-96	sex hormone binding globulin	Homo sapiens	161-165
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Asparagine	93-96	sex hormone binding globulin	Homo sapiens	276-280
17315164-12	2007	CONCLUSIONS: The current results suggested that the codon 327 Asn allele in the SHBG gene may be related to a reduced risk of endometrial cancer among postmenopausal women.	Asparagine	62-65	sex hormone binding globulin	Homo sapiens	80-84
17497286-6	2007	The coding amino acid was Asp in the Genbank gene, while the coding amino acid of Chinese kallikrein gene was Asn.	Asparagine	110-113	kallikrein related peptidase 4	Homo sapiens	90-100
17380207-7	2007	Asparagine secretion by MSCs was directly related to their ASNS expression levels, suggesting a mechanism - increased concentrations of asparagine in the leukemic cell microenvironment - for the protective effects we observed.	Asparagine	0-10	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	59-63
17380207-7	2007	Asparagine secretion by MSCs was directly related to their ASNS expression levels, suggesting a mechanism - increased concentrations of asparagine in the leukemic cell microenvironment - for the protective effects we observed.	Asparagine	136-146	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	59-63
17367717-2	2007	This process is catalyzed by a membrane-associated oligosaccharyl transferase (OST) complex that transfers a preformed oligosaccharide (Glc(3)Man(9)GlcNAc(2)-) to an asparagine (Asn) side-chain acceptor located within the sequon (-Asn-X-Ser/Thr-).	Asparagine	166-176	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	79-82
17258903-2	2007	The missense mutation in exon 8 (GAC--&gt;AAC) causing the amino acid exchange Asp--&gt;Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels.	Asparagine	88-91	glycine-N-acyltransferase	Homo sapiens	42-45
17258903-2	2007	The missense mutation in exon 8 (GAC--&gt;AAC) causing the amino acid exchange Asp--&gt;Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels.	Asparagine	88-91	sex hormone binding globulin	Homo sapiens	171-175
17367717-2	2007	This process is catalyzed by a membrane-associated oligosaccharyl transferase (OST) complex that transfers a preformed oligosaccharide (Glc(3)Man(9)GlcNAc(2)-) to an asparagine (Asn) side-chain acceptor located within the sequon (-Asn-X-Ser/Thr-).	Asparagine	178-181	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	79-82
17367717-2	2007	This process is catalyzed by a membrane-associated oligosaccharyl transferase (OST) complex that transfers a preformed oligosaccharide (Glc(3)Man(9)GlcNAc(2)-) to an asparagine (Asn) side-chain acceptor located within the sequon (-Asn-X-Ser/Thr-).	Asparagine	231-234	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	79-82
17292862-5	2007	A molecular modeling study also suggests that Gln 85 of CYP27A1 simultaneously interacts with Asn 107 and the hydroxyl group of the substrate.	Asparagine	94-97	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	56-63
17242399-4	2007	We report activities for PspF(1-275) mutated in the AAA+ conserved sensor I threonine/asparagine motif (PspF(1-275)(T148A), PspF(1-275)(N149A), and PspF(1-275)(N149S)) within the second region of homology.	Asparagine	86-96	AAA1	Homo sapiens	52-55
17237498-5	2007	Structural models for the ligand-free and ligand-bound states of BLT1 revealed an activation core formed around Asp-64, displaying multiple dynamic interactions with Asn-36, Ser-100, and Asn-281 and a triad of serines, Ser-276, Ser-277, and Ser-278.	Asparagine	166-169	leukotriene B4 receptor	Homo sapiens	65-69
17237498-5	2007	Structural models for the ligand-free and ligand-bound states of BLT1 revealed an activation core formed around Asp-64, displaying multiple dynamic interactions with Asn-36, Ser-100, and Asn-281 and a triad of serines, Ser-276, Ser-277, and Ser-278.	Asparagine	187-190	leukotriene B4 receptor	Homo sapiens	65-69
17292862-6	2007	The fact that Q85L did not contain a heme molecule suggests that the hydrogen bond between Gln 85 and Asn 107 is important for protein folding of CYP27A1.	Asparagine	102-105	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	146-153
17338550-8	2007	Interruption of the triple helix had different effects on secreted MMPs and MT-MMPs, because MT-MMPs could not hydrolyze the Asn-Phe bond but instead cleaved the triple helix closer to the C terminus at a Gly-Gln bond.	Asparagine	125-128	matrix metallopeptidase 2	Homo sapiens	67-71
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Asparagine	64-74	neuropeptide Y	Homo sapiens	190-193
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Asparagine	64-74	pancreatic polypeptide	Homo sapiens	194-196
17341822-4	2007	The structure of the N-linked oligosaccharide of cauxin attached to (83)Asn was a bisecting complex type, Galbeta1-4GlcNAcbeta1-2Manalpha1-3(Galbeta1-4GlcNAcbeta1-2Manalpha1-6)(GlcNAcbeta1-4)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAc.	Asparagine	72-75	carboxylesterase 5A	Homo sapiens	49-55
17315941-1	2007	A (His-Asn)6 domain fused to fatty acid binding protein provides the low-temperature assembly of CdSe nanoparticles starting with common inorganic salt precursors.	Asparagine	7-10	glutamic-oxaloacetic transaminase 2	Homo sapiens	29-55
17446496-5	2007	Site-directed mutageneses have revealed that these inhibitors possess some molecular determinants (Phe-213, Val-227, Tyr-228, Gly-833, and Asn-839) for interaction with NCX1.	Asparagine	139-142	T cell leukemia, homeobox 2	Mus musculus	169-173
17446497-4	2007	Our chimeric and site-directed mutagenesis revealed that Phe-213, Val-227, Tyr-228, Gly-833, and Asn-839 in NCX1 are molecular determinants for interaction with SN-6.	Asparagine	97-100	solute carrier family 8 member A1	Homo sapiens	108-112
17158203-5	2007	The mutation of the putative N-linked glycosylation site (Asn(36)) decreased cAMP production and reduced cell surface expression to 37% of the wild-type LGR7.	Asparagine	58-61	relaxin family peptide receptor 1	Homo sapiens	153-157
17332320-8	2007	These findings suggest that the Asn(418)-linked N-glycan in ErbB3 plays an essential role in regulating receptor heterodimerization with ErbB2 and might have an effect on transforming activity.	Asparagine	32-35	receptor tyrosine-protein kinase erbB-3	Cricetulus griseus	60-65
17332320-8	2007	These findings suggest that the Asn(418)-linked N-glycan in ErbB3 plays an essential role in regulating receptor heterodimerization with ErbB2 and might have an effect on transforming activity.	Asparagine	32-35	receptor tyrosine-protein kinase erbB-2	Cricetulus griseus	137-142
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Asparagine	144-147	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	0-56
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Asparagine	144-147	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	58-62
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Asparagine	144-147	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	85-90
17372243-7	2007	The most common CYP1B1 haplotype was Arg(48)-Ala(119)-Val(432)-Asn(453).	Asparagine	63-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-22
17212372-2	2007	Ten potential asparagine (N)-linked glycosylation sites have been predicted within the ectodomain of nephrin.	Asparagine	14-24	NPHS1 adhesion molecule, nephrin	Homo sapiens	101-108
17070843-10	2007	Here, a double mutation replacing the wild-type Glu,Tyr to Tyr,Asn on TEM1 (res id 104,105) caused a major backbone structural rearrangement of BLIP, changing the composition of two modules but not of other modules within the interface.	Asparagine	63-66	CD248 molecule	Homo sapiens	70-74
17270163-8	2007	Molecular modeling revealed a possible steric clash between the non-planar EC exocyclic ring and residue Asn 191 within the TDG active site, which could account for the lack of TDG activity toward EC.	Asparagine	105-108	thymine DNA glycosylase	Homo sapiens	124-127
17151221-1	2007	The most common single-nucleotide polymorphism (SNP) of the human mu-opioid receptor (hMOR) gene occurs at position 118 (A118G) and results in substitution of asparagine to aspartate at the N-terminus.	Asparagine	159-169	opioid receptor mu 1	Homo sapiens	86-90
17024359-5	2007	Mutations DHFR Asn-108, DHFR Arg-59, and DHPS 436-Ala/Phe were very common (100, 81.1, and 85%, respectively).	Asparagine	15-18	dihydrofolate reductase	Homo sapiens	10-14
17097676-7	2007	Here, we polymerize a Gln/Asn-rich recombinant fragment of Rnq1p into beta-sheet-rich amyloid-like aggregates.	Asparagine	26-29	prion domain-containing protein RNQ1	Saccharomyces cerevisiae S288C	59-64
17220275-4	2007	In addition, CTAD function is inhibited by asparagine hydroxylation catalyzed by FIH1.	Asparagine	43-53	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	81-85
17186219-6	2007	RESULTS: We identified three novel GCK mutations: the insertion of an asparagine residue at position 161 (inserN161) and two missense mutations (M235V and R308W).	Asparagine	70-80	glucokinase	Homo sapiens	35-38
17186219-8	2007	Functional characterisation of these mutations revealed that insertion of asparagine residue N161 fully inactivates GCK, whereas the M235V and R308W mutations only partially impair enzymatic activity.	Asparagine	74-84	glucokinase	Homo sapiens	116-119
17284220-3	2007	The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC--&gt;AAC), changing the encoded serine to asparagine.	Asparagine	146-156	major histocompatibility complex, class II, DR beta 1	Homo sapiens	34-38
17284220-3	2007	The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC--&gt;AAC), changing the encoded serine to asparagine.	Asparagine	146-156	major histocompatibility complex, class II, DR beta 1	Homo sapiens	68-72
17284220-3	2007	The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC--&gt;AAC), changing the encoded serine to asparagine.	Asparagine	146-156	glycine-N-acyltransferase	Homo sapiens	109-112
17290187-7	2007	RESULTS: We demonstrate that malcavernin independently binds to two of the three NPXY (asparagine, proline, undetermined/variable amino acid, and tyrosine) motifs in krit1.	Asparagine	87-97	CCM2 scaffold protein	Homo sapiens	29-40
17290187-7	2007	RESULTS: We demonstrate that malcavernin independently binds to two of the three NPXY (asparagine, proline, undetermined/variable amino acid, and tyrosine) motifs in krit1.	Asparagine	87-97	KRIT1 ankyrin repeat containing	Homo sapiens	166-171
17245537-3	2007	This patient was found heterozygous for a de novo 367 asparagine-encoding variant of the corticosteroid-binding globulin gene, previously described as "transcortin Lyon".	Asparagine	54-64	serpin family A member 6	Homo sapiens	89-120
17238283-1	2007	The addition of asparagine (N)-linked polysaccharide chains (i.e., glycans) to the gp120 and gp41 glycoproteins of human immunodeficiency virus type 1 (HIV-1) envelope is not only required for correct protein folding, but also may provide protection against neutralizing antibodies as a "glycan shield."	Asparagine	16-26	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	83-88
17107962-11	2007	Asn-353 present in the catalytic motif of ADAM12 and other Dll1-processing ADAMs, but absent in ADAM15, is necessary for Dll1 cleavage.	Asparagine	0-3	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	Mus musculus	42-48
17107962-11	2007	Asn-353 present in the catalytic motif of ADAM12 and other Dll1-processing ADAMs, but absent in ADAM15, is necessary for Dll1 cleavage.	Asparagine	0-3	delta like canonical Notch ligand 1	Mus musculus	59-63
17107962-11	2007	Asn-353 present in the catalytic motif of ADAM12 and other Dll1-processing ADAMs, but absent in ADAM15, is necessary for Dll1 cleavage.	Asparagine	0-3	delta like canonical Notch ligand 1	Mus musculus	121-125
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Asparagine	12-15	FAM3 metabolism regulating signaling molecule D	Homo sapiens	8-11
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Asparagine	12-15	FAM3 metabolism regulating signaling molecule D	Homo sapiens	88-91
17994383-1	2007	In Hb J-Singapore, the alpha78(EF7)Asn--&gt;Asp and alpha79(EF8)Ala--&gt;Gly substitutions were initially thought to be genetic mutations.	Asparagine	35-38	FAM3 metabolism regulating signaling molecule D	Homo sapiens	31-34
17158864-0	2007	Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies.	Asparagine	27-30	proteinase 3	Homo sapiens	55-67
17158864-8	2007	Using glycosylation deficient rPR3 mutants we found that glycosylation at Asn-147, but not at Asn-102, is critical for thermal stability, and for optimal hydrolytic activity of PR3.	Asparagine	74-77	proteinase 3	Homo sapiens	31-34
17545225-5	2007	Mutation of the phosphorylatable aspartate to asparagine within the receiver domain creates a version of ARR4 that negatively affects photomorphogenesis.	Asparagine	46-56	response regulator 4	Arabidopsis thaliana	105-109
17708419-3	2007	Mutation of this residue to asparagine in BIB (E71N) knocks out ion channel activity, and when coexpressed with BIB wild-type as shown here generates a dominant-negative effect on ion channel function, measured in the Xenopus oocyte expression system using two-electrode voltage clamp.	Asparagine	28-38	big brain	Drosophila melanogaster	42-45
17708419-11	2007	Mutation of this residue to asparagine in BIB (E71N) knocks out ion channel activity, and when coexpressed with BIB wild-type as shown here generates a dominant-negative effect on ion channel function, measured in the Xenopus oocyte expression system using two-electrode voltage clamp.	Asparagine	28-38	big brain	Drosophila melanogaster	42-45
17245537-3	2007	This patient was found heterozygous for a de novo 367 asparagine-encoding variant of the corticosteroid-binding globulin gene, previously described as "transcortin Lyon".	Asparagine	54-64	serpin family A member 6	Homo sapiens	152-163
16841181-3	2007	To determine the structural/functional significance of glycosylation of the human CD38, the four potential N-linked glycosylation sites asparagine residues, N100, N164, N209 and N219 were mutated.	Asparagine	136-146	CD38 molecule	Homo sapiens	82-86
18029758-4	2007	Recent mutagenesis studies on TLR3 ECD revealed that TLR3 activation depends on a single binding site on the nonglycosylated surface in the C-terminal region that includes H539 and several asparagines in LRRs 17 to 20.	Asparagine	189-200	toll like receptor 3	Homo sapiens	30-34
17259346-4	2007	This mutant form of APE1, termed ED, possesses two amino acid substitutions at active site residues Glu(96) (changed to Gln) and Asp(210) (changed to Asn).	Asparagine	150-153	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	20-24
18029758-4	2007	Recent mutagenesis studies on TLR3 ECD revealed that TLR3 activation depends on a single binding site on the nonglycosylated surface in the C-terminal region that includes H539 and several asparagines in LRRs 17 to 20.	Asparagine	189-200	toll like receptor 3	Homo sapiens	53-57
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Asparagine	164-167	lysozyme	Homo sapiens	25-33
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Asparagine	164-167	lysozyme	Homo sapiens	57-65
18076825-1	2007	The native form of human chorionic gonadotropin (hCG) is a heterodimer protein with two asparagine (Asn)-linked carbohydrate chains on each subunit.	Asparagine	100-103	hypertrichosis 2 (generalised, congenital)	Homo sapiens	49-52
17177603-7	2007	Our results define a signalling pathway leading from DNA damage to up-regulation of the NHE-1 antiport, to intracellular alkalanisation to Bcl-xL deamidation, to apoptosis, representing the first example, to our knowledge, of how deamidation of internal asparagine residues can be regulated in a protein in vivo.	Asparagine	254-264	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	88-93
17177603-7	2007	Our results define a signalling pathway leading from DNA damage to up-regulation of the NHE-1 antiport, to intracellular alkalanisation to Bcl-xL deamidation, to apoptosis, representing the first example, to our knowledge, of how deamidation of internal asparagine residues can be regulated in a protein in vivo.	Asparagine	254-264	BCL2-like 1	Mus musculus	139-145
18076825-1	2007	The native form of human chorionic gonadotropin (hCG) is a heterodimer protein with two asparagine (Asn)-linked carbohydrate chains on each subunit.	Asparagine	88-98	hypertrichosis 2 (generalised, congenital)	Homo sapiens	49-52
18076825-2	2007	Removal of the Asn-linked carbohydrate chains from hCG has resulted in hCG variants with consistent antagonistic properties on isolated murine cells.	Asparagine	15-18	hypertrichosis 2 (generalised, congenital)	Homo sapiens	51-54
18076825-2	2007	Removal of the Asn-linked carbohydrate chains from hCG has resulted in hCG variants with consistent antagonistic properties on isolated murine cells.	Asparagine	15-18	hypertrichosis 2 (generalised, congenital)	Homo sapiens	71-74
18076825-5	2007	Therefore, our aim was to use enzymes to specifically remove Asn-linked carbohydrate chains from hCG in the heterodimer form and analyse the resultant bioactivity.	Asparagine	61-64	hypertrichosis 2 (generalised, congenital)	Homo sapiens	97-100
18076825-7	2007	Endoglycosidases were able to cleave most of the Asn-linked carbohydrate chains from the native hCG.	Asparagine	49-52	hypertrichosis 2 (generalised, congenital)	Homo sapiens	96-99
18076825-9	2007	These results exemplify a simple and efficient method for creating deglycosylated hCG and provide the most direct evidence for the importance of Asn-linked carbohydrate chains in maintaining hCG bioactivity.	Asparagine	145-148	hypertrichosis 2 (generalised, congenital)	Homo sapiens	191-194
17071611-7	2006	However, one glycan, glycan 2 at Asn-42, proved to be of particular importance for the stability of the CD1d-beta(2)m heterodimer.	Asparagine	33-36	CD1d molecule	Homo sapiens	104-108
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Asparagine	97-107	insulin	Homo sapiens	0-7
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Asparagine	97-107	insulin	Homo sapiens	45-52
17071611-7	2006	However, one glycan, glycan 2 at Asn-42, proved to be of particular importance for the stability of the CD1d-beta(2)m heterodimer.	Asparagine	33-36	beta-2-microglobulin	Homo sapiens	109-117
17189197-5	2006	This observation led to a facile identification of the Glu-Leu-Asn-Asn-Asn-Leu sequence as the recognition motif in a proapoptotic protein Par-4 for its interaction with a GUSTAVUS homolog, SSB-1.	Asparagine	63-66	Prader Willi/Angelman region RNA 4	Homo sapiens	139-144
17189197-5	2006	This observation led to a facile identification of the Glu-Leu-Asn-Asn-Asn-Leu sequence as the recognition motif in a proapoptotic protein Par-4 for its interaction with a GUSTAVUS homolog, SSB-1.	Asparagine	63-66	splA/ryanodine receptor domain and SOCS box containing 1	Homo sapiens	190-195
17185229-5	2006	The adenylated sulfoximine has a cytostatic effect on L-asparaginase-resistant MOLT-4 cells cultured in the presence of L-asparaginase, an enzyme that depletes L-asparagine in the growth medium.	Asparagine	160-172	asparaginase and isoaspartyl peptidase 1	Homo sapiens	54-68
17170131-2	2006	Using solid-state NMR we have examined the structure of amyloid fibrils formed in vitro from purified recombinant Sup35(1-253), consisting of the glutamine- and asparagine-rich N-terminal 123-residue prion domain (N) and the adjacent 130-residue highly charged M domain.	Asparagine	161-171	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	114-119
17176052-8	2006	Asp187 of Prx I was mutated to alanine and asparagine, and binding and activity of the mutants with hSrx were compared to those of the wild type.	Asparagine	43-53	peroxiredoxin 1	Homo sapiens	10-15
17182766-10	2006	Additionally, in the M2 segment, our data suggest that the amino acid at the asparagine (N) site of NR1, but not NR3A, contributes to the selectivity filter of NR1/3A channels.	Asparagine	77-87	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	100-103
17182766-10	2006	Additionally, in the M2 segment, our data suggest that the amino acid at the asparagine (N) site of NR1, but not NR3A, contributes to the selectivity filter of NR1/3A channels.	Asparagine	77-87	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	160-163
17015441-5	2006	We identified two potential N-linked glycosylation sites in TRPM8 (Asn-821 and Asn-934) and mutated them to show that only the site in the putative pore region at position 934 is modified and that glycosylation of this site is not absolutely necessary for cell surface expression or responsiveness to icilin, menthol, and cool temperatures.	Asparagine	67-70	transient receptor potential cation channel subfamily M member 8	Cricetulus griseus	60-65
17015441-5	2006	We identified two potential N-linked glycosylation sites in TRPM8 (Asn-821 and Asn-934) and mutated them to show that only the site in the putative pore region at position 934 is modified and that glycosylation of this site is not absolutely necessary for cell surface expression or responsiveness to icilin, menthol, and cool temperatures.	Asparagine	79-82	transient receptor potential cation channel subfamily M member 8	Cricetulus griseus	60-65
17156427-1	2006	BACKGROUND: Aspartyl (asparaginyl)-beta-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation.	Asparagine	79-82	aspartate beta-hydroxylase	Homo sapiens	12-51
17156427-1	2006	BACKGROUND: Aspartyl (asparaginyl)-beta-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation.	Asparagine	79-82	aspartate beta-hydroxylase	Homo sapiens	53-56
17185229-5	2006	The adenylated sulfoximine has a cytostatic effect on L-asparaginase-resistant MOLT-4 cells cultured in the presence of L-asparaginase, an enzyme that depletes L-asparagine in the growth medium.	Asparagine	160-172	asparaginase and isoaspartyl peptidase 1	Homo sapiens	120-134
16963451-6	2006	Although the LDLa module of LGR7 was N-glycosylated at position Asn-14, an LGR7 N14Q mutant retained relaxin binding affinity and cAMP signaling, implying that glycosylation is not essential for optimal LDLa function.	Asparagine	64-67	relaxin/insulin-like family peptide receptor 1	Mus musculus	28-32
17259794-6	2006	Direct sequencing of exons 1-10 of the FSHr gene revealed the presence of a heterozygous AAT/ATT mutation affecting the isoleucine residue at position 411, which was replaced by an asparagine, in the second transmembrane segment (I411N).	Asparagine	181-191	follicle stimulating hormone receptor	Homo sapiens	39-43
17135417-3	2006	Using knock-in mice that carry aspartate-to-asparagine substitutions in a Ca2+-binding site of synaptotagmin-1 (the D232N or D238N substitutions), we now show that the D232N mutation dramatically increases Ca2+-dependent SNARE complex binding by native synaptotagmin-1, but leaves phospholipid binding unchanged.	Asparagine	44-54	synaptotagmin I	Mus musculus	95-110
17055489-4	2006	A lower selective binding was observed to oligomannose-type N-glycans, diantennary N-glycans expressing Le(x) and GalNAcbeta1-4(Fucalpha1-3)GlcNAc (LacdiNAc-fucose), whereas no binding was observed to N-glycans expressing core-fucose linked either alpha1-6 or alpha1-3 to the Asn-linked GlcNAc of N-glycans.	Asparagine	276-279	adrenoceptor alpha 1D	Homo sapiens	248-268
17041897-4	2006	The mutation leads to substitution of the neutral amino acid asparagine (N) by the negatively charged aspartic acid (D) at amino acid number 14, a position that is conserved among Cx26 of different organisms and among many other connexin isoforms.	Asparagine	61-71	gap junction protein beta 2 L homeolog	Xenopus laevis	180-184
16973622-3	2006	It prevents FIH-1 from hydroxylating the asparagine residue (803) of HIF-1alpha in a Cu(II)- and Zn(II)-independent fashion.	Asparagine	41-51	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	12-17
16973622-3	2006	It prevents FIH-1 from hydroxylating the asparagine residue (803) of HIF-1alpha in a Cu(II)- and Zn(II)-independent fashion.	Asparagine	41-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
17075046-8	2006	Like the degradation of poly(ADP-ribose) by ARH3, hydrolysis of O-acetyl-ADP-ribose was abolished by replacement of the vicinal aspartates at positions 77 and 78 of ARH3 with asparagine.	Asparagine	175-185	ADP-ribosylserine hydrolase	Homo sapiens	44-48
17075046-8	2006	Like the degradation of poly(ADP-ribose) by ARH3, hydrolysis of O-acetyl-ADP-ribose was abolished by replacement of the vicinal aspartates at positions 77 and 78 of ARH3 with asparagine.	Asparagine	175-185	ADP-ribosylserine hydrolase	Homo sapiens	165-169
17042482-4	2006	Here, glycosylation in the testis isoform (tACE) has been reduced by Asn-Gln point mutations at N-glycosylation sites, and the crystal structures of mutants having two and four intact sites have been solved to 2.0 A and 2.8 A, respectively.	Asparagine	69-72	ADAM metallopeptidase domain 17	Homo sapiens	43-47
17088436-1	2006	L-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient asparagine for their own needs.	Asparagine	163-173	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
17015824-3	2006	Here, we identify an HIV envelope glycoprotein (Env) variant in the CD4-binding site of gp120, Asn 283 (N283), that is present at a high frequency in brain tissues from AIDS patients with HIV-associated dementia (HAD).	Asparagine	95-98	endogenous retrovirus group K member 20	Homo sapiens	25-46
16940049-8	2006	Thus, the tight Tyr(131)-Asn(127)-Leu(130)-Leu(140)-Ser(142) cluster at the helix D-strand 2A interface of native antithrombin contributes significantly to the stability of the ground state conformation, and tyrosine 131 serves as a heparin-responsive molecular switch during the allosteric activation of ATIII anticoagulant activity.	Asparagine	25-28	serpin family C member 1	Homo sapiens	114-126
16940049-8	2006	Thus, the tight Tyr(131)-Asn(127)-Leu(130)-Leu(140)-Ser(142) cluster at the helix D-strand 2A interface of native antithrombin contributes significantly to the stability of the ground state conformation, and tyrosine 131 serves as a heparin-responsive molecular switch during the allosteric activation of ATIII anticoagulant activity.	Asparagine	25-28	serpin family C member 1	Homo sapiens	305-310
16901746-4	2006	Using site-specific mutagenesis of the histidine precursor of diphthamide, the histidine residue of codon 715 in human EF-2 cDNA was substituted with one of four amino acid residue codons: leucine, methionine, asparagine or glutamine.	Asparagine	210-220	eukaryotic translation elongation factor 2	Homo sapiens	119-123
17015730-3	2006	This epitope is presented in two isoforms containing either Asn or Asp, depending on the structure of the tyrosinase precursor.	Asparagine	60-63	tyrosinase	Homo sapiens	106-116
17015824-3	2006	Here, we identify an HIV envelope glycoprotein (Env) variant in the CD4-binding site of gp120, Asn 283 (N283), that is present at a high frequency in brain tissues from AIDS patients with HIV-associated dementia (HAD).	Asparagine	95-98	endogenous retrovirus group K member 20	Homo sapiens	48-51
17015824-3	2006	Here, we identify an HIV envelope glycoprotein (Env) variant in the CD4-binding site of gp120, Asn 283 (N283), that is present at a high frequency in brain tissues from AIDS patients with HIV-associated dementia (HAD).	Asparagine	95-98	CD4 molecule	Homo sapiens	68-71
17015824-3	2006	Here, we identify an HIV envelope glycoprotein (Env) variant in the CD4-binding site of gp120, Asn 283 (N283), that is present at a high frequency in brain tissues from AIDS patients with HIV-associated dementia (HAD).	Asparagine	95-98	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	88-93
17003112-4	2006	After the identification of a series of ankyrin repeat domain (ARD)-containing proteins in a screen for proteins interacting with FIH, the ARDs of p105 (NFKB1) and IkappaBalpha were shown to be efficiently hydroxylated by FIH at specific Asn residues in the hairpin loops linking particular ankyrin repeats.	Asparagine	238-241	nuclear factor kappa B subunit 1	Homo sapiens	147-151
17003112-4	2006	After the identification of a series of ankyrin repeat domain (ARD)-containing proteins in a screen for proteins interacting with FIH, the ARDs of p105 (NFKB1) and IkappaBalpha were shown to be efficiently hydroxylated by FIH at specific Asn residues in the hairpin loops linking particular ankyrin repeats.	Asparagine	238-241	nuclear factor kappa B subunit 1	Homo sapiens	153-158
17003112-4	2006	After the identification of a series of ankyrin repeat domain (ARD)-containing proteins in a screen for proteins interacting with FIH, the ARDs of p105 (NFKB1) and IkappaBalpha were shown to be efficiently hydroxylated by FIH at specific Asn residues in the hairpin loops linking particular ankyrin repeats.	Asparagine	238-241	NFKB inhibitor alpha	Homo sapiens	164-176
16828555-7	2006	Accordingly, site-directed mutagenesis of Gln-148 of 15-PGDH to alanine, glutamic acid, histidine, and asparagine (Q148A, Q148E, Q148H, and Q148N) was carried out.	Asparagine	103-113	carbonyl reductase 1	Homo sapiens	53-60
17002676-8	2006	Non-heme ferrous iron containing hydroxylases use dioxygen and 2-oxoglutarate to specifically target proline and an asparagine residue in HIF-1alpha.	Asparagine	116-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
16904071-5	2006	Cat and dog CCK-58 are identical except for position 40 which is serine in cat and asparagine in dog.	Asparagine	83-93	cholecystokinin	Oryctolagus cuniculus	12-15
16980656-4	2006	RESULTS: Mutation studies revealed an heterozygous A to G mutation at GRL cDNA position 1220 in three DMD patients resulting in an asparagine to serine amino acid change at amino acid position 363 (N363S).	Asparagine	131-141	nuclear receptor subfamily 3 group C member 1	Homo sapiens	70-73
16981714-2	2006	The PTX3 C-terminal domain is required for C1q recognition and complement activation and contains a single N-glycosylation site on Asn 220.	Asparagine	131-134	pentraxin 3	Homo sapiens	4-8
16870620-4	2006	In the neuronal glutamate transporter EAAC1, the equivalent residues are asparagine 366 and aspartate 368.	Asparagine	73-83	solute carrier family 1 member 1	Homo sapiens	38-43
16725155-9	2006	Detailed analysis of the active site suggests why the plant enzyme hydrolyzes asparagine and its beta-peptides but is inactive towards substrates accepted by similar Ntn-hydrolases, such as taspase1, an enzyme implicated in some human leukemias.	Asparagine	78-88	taspase 1	Homo sapiens	190-198
16864577-9	2006	Other good nitrogen sources, e.g. glutamine, serine, or asparagine, restricted Gln3-Myc(13) to the cytoplasm of both wild type and npr1Delta cells.	Asparagine	56-66	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	79-83
16864579-2	2006	After the transfer of a GlcNAc residue to Asn-bound Man(5)GlcNAc(2) by N-acetylglucosaminyltransferase I, an alpha-mannosidase (EC 3.2.1.114) removes one alpha1,3-linked and one alpha1,6-linked mannose residue.	Asparagine	42-45	Alpha-mannosidase	Caenorhabditis elegans	109-126
16894346-3	2006	In the present study, we assessed whether point mutations of critical asparagine residues located within the selectivity filter of NR1 and NR2A subunits of NMDA receptor-channel affect voltage-dependent block by 5-HT.	Asparagine	70-80	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	131-134
16894346-3	2006	In the present study, we assessed whether point mutations of critical asparagine residues located within the selectivity filter of NR1 and NR2A subunits of NMDA receptor-channel affect voltage-dependent block by 5-HT.	Asparagine	70-80	glutamate receptor ionotropic, NMDA 2A-like	Xenopus laevis	139-143
16894346-3	2006	In the present study, we assessed whether point mutations of critical asparagine residues located within the selectivity filter of NR1 and NR2A subunits of NMDA receptor-channel affect voltage-dependent block by 5-HT.	Asparagine	70-80	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	156-169
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Asparagine	39-49	prion protein	Mus musculus	104-107
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Asparagine	39-49	prion protein	Mus musculus	161-164
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Asparagine	39-49	prion protein	Mus musculus	161-164
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Asparagine	39-49	prion protein	Mus musculus	161-164
16790440-4	2006	Our results show that the NH(2)-terminal third of NPS, in particular residues Phe-2, Arg-3, Asn-4, and Val-6, are necessary and sufficient for activation of NPSR.	Asparagine	92-95	neuropeptide S receptor 1	Homo sapiens	157-161
16786512-1	2006	We describe a novel missense mutation (Aspartic acid to Asparagine, p.D419N (g.1371G&gt;A, c.1255G&gt;A) within exon 9 of SH3BP2 in a patient with cherubism, an autosomal dominant syndrome characterized by excessive osteoclastic bone resorption of the jaw.	Asparagine	56-66	SH3 domain binding protein 2	Homo sapiens	122-128
16894346-8	2006	CONCLUSION AND IMPLICATIONS: The block of NMDA receptor-channels by 5-HT depends on the NR1-subunit asparagine residue and to a lesser extent on the NR2A-subunit asparagine residues.	Asparagine	100-110	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	42-55
16894346-8	2006	CONCLUSION AND IMPLICATIONS: The block of NMDA receptor-channels by 5-HT depends on the NR1-subunit asparagine residue and to a lesser extent on the NR2A-subunit asparagine residues.	Asparagine	162-172	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	42-55
17091764-3	2006	As the name implies, asparaginase catalyzes the deamination of asparagine to aspartic acid.	Asparagine	63-73	asparaginase	Homo sapiens	21-33
16774919-6	2006	First, we showed that if one of the Mg2+ cations is removed, the Asp/Asn binding specificity is strongly reduced.	Asparagine	69-72	mucin 7, secreted	Homo sapiens	36-39
16679374-8	2006	Simulations suggest that within the sheet, the driving forces to associate and stabilize are interstrand backbone-backbone and side chain-side chain hydrogen bonds, whereas between the sheets, shape-complementary by the dry polar steric zipper via the side chains of Asn-2, Gln-4, and Asn-6 holds the sheets together, as proposed in an earlier study.	Asparagine	267-270	glutamine--tRNA ligase	Saccharomyces cerevisiae S288C	274-279
16880530-6	2006	Mutation of aspartic residues to asparagine allowed us to map the caspase cleavage site in the juxtamembrane region of ALK.	Asparagine	33-43	ALK receptor tyrosine kinase	Homo sapiens	119-122
16845394-5	2006	Similarly, an asparagine-to-glycine substitution in the lectin-EGF-like domain interface of L-selectin enhanced rolling adhesion under shear flow.	Asparagine	14-24	selectin L	Homo sapiens	92-102
16425271-0	2006	Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children"s Oncology Group study (CCG-1941).	Asparagine	0-10	asparaginase	Homo sapiens	45-57
16720571-5	2006	The results of this study indicate that (i) the effect of hNPS is mimicked by the fragment hNPS-(1-10); (ii) Phe(2), Arg(3), and Asn(4) are crucial for biological activity; (iii) the sequence Thr(8)-Gly(9)-Met(10) is important for receptor activation, although with non-stringent chemical requirements; and (iv) the sequence Val(6)-Gly(7) acts as a hinge region between the two above-mentioned domains.	Asparagine	129-132	neuropeptide S	Homo sapiens	58-62
16819971-5	2006	SDS-PAGE of the transfectants demonstrated that these mutants migrated lower than wild-type TLR2 and their molecular masses decreased as the number of mutated Asn residues increased.	Asparagine	159-162	toll like receptor 2	Homo sapiens	92-96
16595656-5	2006	Using confocal microscopy and different truncated and point mutants of hENT1-YFP (yellow fluorescent protein) expressed in Madin-Darby canine kidney cells, we identified amino acid residues Pro(71),Glu(72), and Asn(74) (the PEXN motif) of hENT1 as important in mitochondrial targeting of hENT1.	Asparagine	211-214	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	71-76
16685272-0	2006	Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues.	Asparagine	94-104	dermcidin	Homo sapiens	0-9
16816908-4	2006	This newly described mutation predicts the substitution of an aspartate by asparagine (D770N) in the second fibronectin (Fn2) domain of the extracellular portion of the mature L1 protein.	Asparagine	75-85	fibronectin 1	Homo sapiens	108-119
16477434-9	2006	Finally, replacement of the conserved aspartate with asparagine in human RhAG and RhCG proteins resulted in the loss of bi-directional transport function.	Asparagine	53-63	Rh associated glycoprotein	Homo sapiens	73-77
16563404-1	2006	The first hemoglobin (Hb) variant carrying a mutation at beta4 was identified as beta4(A1)Thr-->Asn or Hb Wurzburg and constituted 38% of the total hemoglobin.	Asparagine	96-99	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	57-62
16691551-6	2006	Moreover, the equine beta-casein was able to deamidate spontaneously, at the level of Asn in the potential deamidation motif (135)Asn-Gly(136).	Asparagine	86-89	casein beta	Equus caballus	21-32
16690929-2	2006	The recombinant MV, based on a SLAM-using clinical isolate in which asparagine at position 481 of the haemagglutinin was replaced with tyrosine, was generated.	Asparagine	68-78	signaling lymphocytic activation molecule family member 1	Homo sapiens	31-35
16500955-6	2006	Mutations directed toward the beta-3a strand suggested a possible heme-binding interaction centered on Asn-403 and a structural role for substrate contact residues Thr-402 and Ser-404.	Asparagine	103-106	basic helix-loop-helix family member e22	Homo sapiens	30-37
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P&lt;0.001), diastolic (P&lt;0.0001), and mean BP (P&lt;0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P&lt;0.0001).	Asparagine	4-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
16368742-0	2006	Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.	Asparagine	82-85	transient receptor potential cation channel subfamily V member 4	Homo sapiens	73-78
16368742-2	2006	Mutation of this residue from Asn to Gln (i.e., TRPV4(N651Q)) resulted in loss of a slower migrating band on anti-TRPV4 immunoblots and a marked reduction in lectin-precipitable TRPV4 immunoreactivity.	Asparagine	30-33	transient receptor potential cation channel subfamily V member 4	Homo sapiens	48-53
16368742-2	2006	Mutation of this residue from Asn to Gln (i.e., TRPV4(N651Q)) resulted in loss of a slower migrating band on anti-TRPV4 immunoblots and a marked reduction in lectin-precipitable TRPV4 immunoreactivity.	Asparagine	30-33	transient receptor potential cation channel subfamily V member 4	Homo sapiens	114-119
16368742-2	2006	Mutation of this residue from Asn to Gln (i.e., TRPV4(N651Q)) resulted in loss of a slower migrating band on anti-TRPV4 immunoblots and a marked reduction in lectin-precipitable TRPV4 immunoreactivity.	Asparagine	30-33	transient receptor potential cation channel subfamily V member 4	Homo sapiens	114-119
16808171-3	2006	An immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein p53 and the cell proliferation upon the action of lysine, asparagine, and glutamic acid.	Asparagine	175-185	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	117-120
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P&lt;0.001), diastolic (P&lt;0.0001), and mean BP (P&lt;0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P&lt;0.0001).	Asparagine	8-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P&lt;0.001), diastolic (P&lt;0.0001), and mean BP (P&lt;0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P&lt;0.0001).	Asparagine	8-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
16585408-7	2006	Coupling of the renin-angiotensin system to systemic resistance and BP was diminished in Asn/Asn homozygotes, suggesting genetic pleiotropy of Thr431Asn, confirmed by bivariate genetic analyses.	Asparagine	89-92	renin	Homo sapiens	16-21
16585408-7	2006	Coupling of the renin-angiotensin system to systemic resistance and BP was diminished in Asn/Asn homozygotes, suggesting genetic pleiotropy of Thr431Asn, confirmed by bivariate genetic analyses.	Asparagine	93-96	renin	Homo sapiens	16-21
16427346-8	2006	A 1876G&gt;A substitution changing an aspartic acid to asparagine (D626N) was identified in LDB3 in four members of two families with LVNC.	Asparagine	55-65	LIM domain binding 3	Homo sapiens	92-96
16597835-9	2006	Our results further imply that Ile in place of Asn in the FDH hydrolase catalytic center is an important determinant for hydrolase catalysis as opposed to transferase catalysis.	Asparagine	47-50	aldehyde dehydrogenase 1 family member L1	Homo sapiens	58-61
16786295-9	2006	The recombinant LaNIT4 enzymes, like Arabidopsis NIT4, hydrolyze cyanoalanine to asparagine and aspartic acid but show a much higher cyanoalanine-hydratase activity.	Asparagine	81-91	nitrilase 4	Arabidopsis thaliana	18-22
16449230-13	2006	Differential sensitivities of the mutants to inhibition by AlF, MgF, and BeF made it possible to distinguish different roles of Asn(706) and Glu(183).	Asparagine	128-131	general transcription factor IIA subunit 1 like	Homo sapiens	59-62
16584196-1	2006	The kinetics and thermodynamics of the alkaline and acid conformational transitions of a Lys 79 --&gt; Ala/Asn 52 --&gt; Gly (A79G52) variant of iso-1-cytochrome c are studied.	Asparagine	107-110	eukaryotic translation initiation factor 1	Homo sapiens	145-150
16584196-1	2006	The kinetics and thermodynamics of the alkaline and acid conformational transitions of a Lys 79 --&gt; Ala/Asn 52 --&gt; Gly (A79G52) variant of iso-1-cytochrome c are studied.	Asparagine	107-110	cytochrome c, somatic	Homo sapiens	151-163
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Asparagine	31-34	cytochrome c, somatic	Homo sapiens	118-130
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Asparagine	31-34	cytochrome c, somatic	Homo sapiens	212-224
16449230-13	2006	Differential sensitivities of the mutants to inhibition by AlF, MgF, and BeF made it possible to distinguish different roles of Asn(706) and Glu(183).	Asparagine	128-131	insulin like growth factor 1	Homo sapiens	64-67
16449230-13	2006	Differential sensitivities of the mutants to inhibition by AlF, MgF, and BeF made it possible to distinguish different roles of Asn(706) and Glu(183).	Asparagine	128-131	Aly/REF export factor	Homo sapiens	73-76
16407226-7	2006	Altering the P1-P1" Arg-Asn sequence compromised Serp-1 protease-inhibitory activity and anti-inflammatory activity in animal models; P1-P1" Ala-Ala mutants were inactive, P1 Met increased remodeling, and P1" Thr increased thrombosis.	Asparagine	24-27	stress associated endoplasmic reticulum protein 1	Homo sapiens	49-55
16547235-4	2006	In contrast, a conservative (serine vs asparagine) exchange at P7 primed cross-reactive CD8 T cells that preferentially recognized the priming variant.	Asparagine	39-49	CD8a molecule	Homo sapiens	88-91
16755491-3	2006	The origin of this variant is a mutation in codon 47 (GAC --&gt; CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process.	Asparagine	129-139	glutaminase	Homo sapiens	54-57
16755491-3	2006	The origin of this variant is a mutation in codon 47 (GAC --&gt; CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process.	Asparagine	129-139	hemoglobin subunit alpha 2	Homo sapiens	77-90
16585195-4	2006	Hydroxylation of two proline residues by prolyl hydroxylase domain (PHD) 2 protein earmarks the protein for degradation, whereas hydroxylation of an asparagine residue by factor-inhibiting HIF-1 (FIH-1 or FIH) reduces its transcriptional activity.	Asparagine	149-159	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	171-194
16306051-3	2006	By examining mutants of mST3Gal-V, in which each asparagine was replaced with glutamine (N180Q, N224Q, N334Q), we determined that all three sites are N-glycosylated and that each N-glycan is required for enzyme activity.	Asparagine	49-59	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	24-33
16407218-5	2006	We investigated the mechanism of formation of complexes between alpha2M and MBL and concluded that they form by the direct binding of oligomannose glycans Man(5-7) occupying Asn-846 on alpha2M to the lectin domains (carbohydrate recognition domains) of MBL.	Asparagine	174-177	alpha-2-macroglobulin	Homo sapiens	64-71
16407218-5	2006	We investigated the mechanism of formation of complexes between alpha2M and MBL and concluded that they form by the direct binding of oligomannose glycans Man(5-7) occupying Asn-846 on alpha2M to the lectin domains (carbohydrate recognition domains) of MBL.	Asparagine	174-177	mannose binding lectin 2	Homo sapiens	76-79
16407218-5	2006	We investigated the mechanism of formation of complexes between alpha2M and MBL and concluded that they form by the direct binding of oligomannose glycans Man(5-7) occupying Asn-846 on alpha2M to the lectin domains (carbohydrate recognition domains) of MBL.	Asparagine	174-177	alpha-2-macroglobulin	Homo sapiens	185-192
16487174-1	2006	L-asparaginase is active in the treatment of acute lymphoblastic leukaemia (ALL) through the depletion of serum asparagine.	Asparagine	112-122	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
16413680-1	2006	A novel phospholipase A2 (PLA2) with Asn at its site 49 was purified from the snake venom of Protobothrops mucrosquamatus by using SP-Sephadex C25, Superdex 75, Heparin-Sepharose (FF) and HPLC reverse-phage C18 chromatography and designated as TM-N49.	Asparagine	37-40	phospholipase A2, group IB, pancreas	Mus musculus	8-24
16413680-1	2006	A novel phospholipase A2 (PLA2) with Asn at its site 49 was purified from the snake venom of Protobothrops mucrosquamatus by using SP-Sephadex C25, Superdex 75, Heparin-Sepharose (FF) and HPLC reverse-phage C18 chromatography and designated as TM-N49.	Asparagine	37-40	phospholipase A2, group IB, pancreas	Mus musculus	26-30
16310227-4	2006	We show that, in addition to glutamate (Glu), cysteine, aspartate and asparagine also lead to the activation of mGlu3, 4 and 5.	Asparagine	70-80	glutamate receptor, metabotropic 3	Mus musculus	112-117
16539681-0	2006	Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism.	Asparagine	100-110	N-terminal asparagine amidase	Rattus norvegicus	112-117
16539681-2	2006	We have for the first time cloned and identified Ntan1 (amidohydrolase for N-terminal asparagine) as a magnetism responsive gene in rat brain.	Asparagine	86-96	N-terminal asparagine amidase	Rattus norvegicus	49-54
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Asparagine	89-92	melanocortin 4 receptor	Sus scrofa	34-57
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Asparagine	89-92	melanocortin 4 receptor	Sus scrofa	59-63
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Asparagine	89-92	melanocortin 4 receptor	Sus scrofa	143-147
16408313-3	2006	We used molecular-dynamics free-energy simulations and experiments to compare the binding of the substrate Asp and its electrically neutral analogue Asn to AspRS.	Asparagine	149-152	aspartyl-tRNA synthetase 1	Homo sapiens	156-161
16408313-9	2006	In asparaginyl-tRNA synthetase, a close homologue of AspRS, a few binding-pocket differences modify the charge balance so that asparagine binding predominates.	Asparagine	127-137	aspartyl-tRNA synthetase 1	Homo sapiens	53-58
16371009-0	2006	Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.	Asparagine	43-53	purinergic receptor P2X 1	Homo sapiens	122-126
16338099-8	2006	CONCLUSION: The results of this study suggest an association between the ATM codon 1853 Asn/Asp and Asn/Asn genotypes with the development of Grade 3 fibrosis in breast cancer patients treated with radiotherapy.	Asparagine	88-91	ATM serine/threonine kinase	Homo sapiens	73-76
16338099-8	2006	CONCLUSION: The results of this study suggest an association between the ATM codon 1853 Asn/Asp and Asn/Asn genotypes with the development of Grade 3 fibrosis in breast cancer patients treated with radiotherapy.	Asparagine	100-103	ATM serine/threonine kinase	Homo sapiens	73-76
16330541-0	2006	The carbohydrate at FcgammaRIIIa Asn-162.	Asparagine	33-36	Fc gamma receptor IIIa	Homo sapiens	20-32
16199427-1	2006	BACKGROUND: Recently a polymorphic variant of the FSH receptor in which amino acid asparagine (Asn) at position 680 is replaced by serine (Ser) was found.	Asparagine	95-98	follicle stimulating hormone receptor	Homo sapiens	50-62
16415881-3	2006	Collectively, our data reveal that SET7/9 recognizes a conserved K/R-S/T/A motif preceding the lysine substrate and has a propensity to bind aspartates and asparagines on the C-terminal side of the lysine target.	Asparagine	156-167	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	35-41
16286478-5	2006	This amino acid is highly conserved among all the type III RTKs and corresponds to aspartic acid, but in VEGFR-1 it is substituted to asparagine.	Asparagine	134-144	fms related receptor tyrosine kinase 1	Homo sapiens	105-112
16314412-6	2006	The paratope predominantly consists of two short sequences in the heavy chain CDR1 (Asn-31 and Tyr-32) and CDR3 (Asp-99, Pro-101, Tyr-102 and Tyr-103), forming one patch on the surface of the antibody.	Asparagine	84-87	cerebellar degeneration related protein 1	Homo sapiens	78-82
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Asparagine	251-261	ADP-ribosylarginine hydrolase	Homo sapiens	40-44
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Asparagine	251-261	ADP-ribosylserine hydrolase	Homo sapiens	96-100
16286478-9	2006	Furthermore, mutation of the invariable aspartic acid to asparagine in VEGFR-2 lowered the autophosphorylation of activation loop tyrosines 1052 and 1057.	Asparagine	57-67	kinase insert domain receptor	Homo sapiens	71-78
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Asparagine	251-261	poly(ADP-ribose) glycohydrolase	Homo sapiens	118-122
16607083-0	2006	Novel fibrinogen mutation (gamma 313 Ser--&gt;Asn) associated with hypofibrinogenemia in two unrelated families.	Asparagine	46-49	fibrinogen beta chain	Homo sapiens	6-16
16150941-0	2006	Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.	Asparagine	92-95	fms related receptor tyrosine kinase 3	Homo sapiens	107-111
16398656-6	2006	Mutation of the invariant asparagine residue at position 51 of the homeodomain - which is required for efficient DNA binding - released the block, consistent with the notion that TLX1 inhibits thymocyte differentiation and promotes T-cell oncogenesis by functioning as a transcription factor.	Asparagine	26-36	T cell leukemia homeobox 1	Homo sapiens	179-183
17717965-8	2006	Native or pegylated L-asparaginase (ASNase or PEG-ASNase) are highly specific for the deamination of L-asparagine (Asn) to aspartic acid and ammonia.	Asparagine	101-113	asparaginase and isoaspartyl peptidase 1	Homo sapiens	20-34
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	279-282	endothelin 1	Homo sapiens	38-42
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	279-282	endothelin receptor type A	Homo sapiens	47-52
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	279-282	endothelin receptor type A	Homo sapiens	47-51
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	283-286	endothelin 1	Homo sapiens	38-42
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	283-286	endothelin receptor type A	Homo sapiens	47-52
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Asparagine	283-286	endothelin receptor type A	Homo sapiens	47-51
16840225-0	2006	Hb Bleuland [alpha108(G15)Thr-->Asn, ACC-->AAC (alpha2)]: a new abnormal hemoglobin associated with a mild alpha-thalassemia phenotype.	Asparagine	32-35	hemoglobin subunit gamma 2	Homo sapiens	64-83
16702018-0	2006	The evolution from asparagine or threonine to cysteine in position 146 contributes to generation of a more efficient and stable form of muscle creatine kinase in higher vertebrates.	Asparagine	19-29	creatine kinase M-type	Oryctolagus cuniculus	136-158
17717965-8	2006	Native or pegylated L-asparaginase (ASNase or PEG-ASNase) are highly specific for the deamination of L-asparagine (Asn) to aspartic acid and ammonia.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	20-34
16728410-1	2006	The MGOUN3(MGO3)/BRUSHY1(BRU1)/TONSOKU(TSK) gene of Arabidopsis thaliana encodes a nuclear leucine-glycine-asparagine (LGN) domain protein that may be implicated in chromatin dynamics and genome maintenance.	Asparagine	107-117	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	4-10
16728410-1	2006	The MGOUN3(MGO3)/BRUSHY1(BRU1)/TONSOKU(TSK) gene of Arabidopsis thaliana encodes a nuclear leucine-glycine-asparagine (LGN) domain protein that may be implicated in chromatin dynamics and genome maintenance.	Asparagine	107-117	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	11-15
16728410-1	2006	The MGOUN3(MGO3)/BRUSHY1(BRU1)/TONSOKU(TSK) gene of Arabidopsis thaliana encodes a nuclear leucine-glycine-asparagine (LGN) domain protein that may be implicated in chromatin dynamics and genome maintenance.	Asparagine	107-117	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	39-42
16871362-5	2006	The FSHR genotype distribution was 41.8% for Asn/Asn, 45.6% for Asn/Ser, and 12.5% for Ser/Ser FSHR genotype groups.	Asparagine	45-48	follicle stimulating hormone receptor	Homo sapiens	4-8
17013727-3	2006	Further examinations established multiple endocrine neoplasia type 1 (MEN1) with a germline mutation at codon 1153 (T->A) in exon 7, causing an amino-acid change, from isoleucine to asparagine (Ile348Asn), in the MEN1 gene.	Asparagine	182-192	menin 1	Homo sapiens	33-68
17013727-3	2006	Further examinations established multiple endocrine neoplasia type 1 (MEN1) with a germline mutation at codon 1153 (T->A) in exon 7, causing an amino-acid change, from isoleucine to asparagine (Ile348Asn), in the MEN1 gene.	Asparagine	182-192	menin 1	Homo sapiens	70-74
16871362-5	2006	The FSHR genotype distribution was 41.8% for Asn/Asn, 45.6% for Asn/Ser, and 12.5% for Ser/Ser FSHR genotype groups.	Asparagine	49-52	follicle stimulating hormone receptor	Homo sapiens	4-8
16871362-5	2006	The FSHR genotype distribution was 41.8% for Asn/Asn, 45.6% for Asn/Ser, and 12.5% for Ser/Ser FSHR genotype groups.	Asparagine	49-52	follicle stimulating hormone receptor	Homo sapiens	4-8
16533566-4	2006	Mutation of the poly ED motif to alanine or glutamine/asparagine greatly enhanced voltage-dependent inactivation, shifting the voltage dependence to negative potentials by &gt;50 mV and conferring a neuronal like inactivation kinetics onto Ca(V)1.2.	Asparagine	54-64	caveolin-1	Oryctolagus cuniculus	240-246
16406879-1	2006	PURPOSE: GnT-V is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagine (N)-linked oligosaccharides of cell proteins.	Asparagine	87-97	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	9-14
16406879-1	2006	PURPOSE: GnT-V is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagine (N)-linked oligosaccharides of cell proteins.	Asparagine	87-97	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	43-50
17116467-3	2006	The deglycosylation reaction by PNGase brings about two major changes on substrate proteins; one is a removal of N-glycan chains, and the other is the introduction of negative charge(s) into the core peptide by converting glycosylated asparagine residue(s) into aspartic acid residue(s).	Asparagine	235-245	N-glycanase 1	Homo sapiens	32-38
16892900-2	2006	L-asparaginase leads to enzymatic cleavage of L-asparagine (amino acid essential for lymphoblasts" growth) to ammonia and L-aspartic acid, what results in depletion of L-asparagine in a serum and cerebrospinal fluid, and finally leads to destruction of lymphoblasts, which lack ability of endogenic L-asparagine production.	Asparagine	46-58	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
16328052-4	2006	rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases.	Asparagine	151-154	ubiquitin specific peptidase 7	Rattus norvegicus	0-6
16892900-2	2006	L-asparaginase leads to enzymatic cleavage of L-asparagine (amino acid essential for lymphoblasts" growth) to ammonia and L-aspartic acid, what results in depletion of L-asparagine in a serum and cerebrospinal fluid, and finally leads to destruction of lymphoblasts, which lack ability of endogenic L-asparagine production.	Asparagine	168-180	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
16892900-2	2006	L-asparaginase leads to enzymatic cleavage of L-asparagine (amino acid essential for lymphoblasts" growth) to ammonia and L-aspartic acid, what results in depletion of L-asparagine in a serum and cerebrospinal fluid, and finally leads to destruction of lymphoblasts, which lack ability of endogenic L-asparagine production.	Asparagine	168-180	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
16363805-9	2005	Confirming the critical roles of the identified residues, abnormal fibrinogen Kaiserslautern, in which gammaLys380 is replaced by Asn, demonstrated delayed clot retraction and impaired alpha(IIb)beta3 binding.	Asparagine	130-133	fibrinogen beta chain	Homo sapiens	67-77
17233480-5	2006	In particular, it was demonstrated that the register of these amino acids comprises Asn-25 critical for virus binding with primary cell receptor CD4 as well as Arg-3 critical for utilization of CCR5 coreceptor and heparan sulfate proteoglycan syndecans.	Asparagine	84-87	CD4 molecule	Homo sapiens	145-148
17233480-5	2006	In particular, it was demonstrated that the register of these amino acids comprises Asn-25 critical for virus binding with primary cell receptor CD4 as well as Arg-3 critical for utilization of CCR5 coreceptor and heparan sulfate proteoglycan syndecans.	Asparagine	84-87	C-C motif chemokine receptor 5	Homo sapiens	194-198
16732932-6	2006	The plasma asparagine levels in the patients were all above 5 micromol/L except case 4 (4.91 micromol/L) before receiving L-Asp, and were all decreased below 0.5 micromol/L five days after receiving low dose L-Asp, except case 3 (3.70 micromol/L), the results being like that of receiving standard dose L-Asp.	Asparagine	11-21	asparaginase and isoaspartyl peptidase 1	Homo sapiens	208-213
16732932-6	2006	The plasma asparagine levels in the patients were all above 5 micromol/L except case 4 (4.91 micromol/L) before receiving L-Asp, and were all decreased below 0.5 micromol/L five days after receiving low dose L-Asp, except case 3 (3.70 micromol/L), the results being like that of receiving standard dose L-Asp.	Asparagine	11-21	asparaginase and isoaspartyl peptidase 1	Homo sapiens	208-213
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Asparagine	233-236	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
16256074-6	2005	Glycosidase treatment and site-directed mutagenesis confirmed that CeCNX-1 is N-glycosylated at two asparagine residues of Asn(203) and Asn(571).	Asparagine	100-110	Calnexin	Caenorhabditis elegans	67-74
16256074-6	2005	Glycosidase treatment and site-directed mutagenesis confirmed that CeCNX-1 is N-glycosylated at two asparagine residues of Asn(203) and Asn(571).	Asparagine	123-126	Calnexin	Caenorhabditis elegans	67-74
16256074-6	2005	Glycosidase treatment and site-directed mutagenesis confirmed that CeCNX-1 is N-glycosylated at two asparagine residues of Asn(203) and Asn(571).	Asparagine	136-139	Calnexin	Caenorhabditis elegans	67-74
16234244-7	2005	We report that the proximal two-thirds of TMD4 of PS1, including the conserved Trp-Asn-Phe sequence, are required for its interaction with Pen-2.	Asparagine	83-86	presenilin 1	Homo sapiens	50-53
16234244-7	2005	We report that the proximal two-thirds of TMD4 of PS1, including the conserved Trp-Asn-Phe sequence, are required for its interaction with Pen-2.	Asparagine	83-86	presenilin enhancer, gamma-secretase subunit	Homo sapiens	139-144
16266689-3	2005	The peptide backbone of CD52, consisting of only 12 aminoacids, is generally considered no more than a scaffold for post-translational modifications, such as GPI-anchor and especially N-glycosylation which occur at the third asparagine.	Asparagine	225-235	CD52 molecule	Homo sapiens	24-28
16107205-4	2005	Human DNase X, ectopically expressed in HeLa S3 cells, is located in the ER (endoplasmic reticulum) and is modified by an N-linked glycosylation at Asn-243.	Asparagine	148-151	deoxyribonuclease 1 like 1	Homo sapiens	6-13
16301800-6	2005	The conserved asparagine from block III, which provides a hydrogen bond for an oxyanion hole in the SGNH-hydrolase superfamily enzymes, is missing in At4g34215 and is functionally replaced by Gln30 from block I.	Asparagine	14-24	carbohydrate esterase, putative (DUF303)	Arabidopsis thaliana	150-159
16429164-8	2005	Moreover, even in the absence of Dal5p and Ptr2p, an additional activity--almost certainly the periplasmic asparaginase II Asp3p--facilitates the utilization of dipeptides with C-terminal asparagine residues by a different strategy.	Asparagine	188-198	Ptr2p	Saccharomyces cerevisiae S288C	43-48
16252083-5	2005	We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --&gt; G transition at 127 position producing an Asn --&gt; Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --&gt; A transition at 1032 position resulting in a Gly --&gt; Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression.	Asparagine	157-160	mutS homolog 2	Homo sapiens	91-96
16254684-6	2005	The CYP1A1 M2 (isoleucine to valine) polymorphism in exon 7 and CYP1A1 M4 (threonine to asparagine) variant in codon 461 of the CYP1A1 gene were found to be very rare in our study subjects.	Asparagine	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
16254684-6	2005	The CYP1A1 M2 (isoleucine to valine) polymorphism in exon 7 and CYP1A1 M4 (threonine to asparagine) variant in codon 461 of the CYP1A1 gene were found to be very rare in our study subjects.	Asparagine	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
16218754-10	2005	Regardless of statistically significant differences between local structures of the HIV(MN) V3 loop in water and in water/TFE solution, over one-third of residues keeps their conformational states; the register of these amino acids comprises Asn-25 critical for virus binding with primary cell receptor CD4 as well as Arg-3 critical for utilization of CCR5 coreceptor.	Asparagine	242-245	CD4 molecule	Homo sapiens	303-306
16218754-10	2005	Regardless of statistically significant differences between local structures of the HIV(MN) V3 loop in water and in water/TFE solution, over one-third of residues keeps their conformational states; the register of these amino acids comprises Asn-25 critical for virus binding with primary cell receptor CD4 as well as Arg-3 critical for utilization of CCR5 coreceptor.	Asparagine	242-245	C-C motif chemokine receptor 5	Homo sapiens	352-356
16429164-8	2005	Moreover, even in the absence of Dal5p and Ptr2p, an additional activity--almost certainly the periplasmic asparaginase II Asp3p--facilitates the utilization of dipeptides with C-terminal asparagine residues by a different strategy.	Asparagine	188-198	asparaginase ASP3-1	Saccharomyces cerevisiae S288C	123-128
15929079-7	2005	The wild-type amino acid Asn of this polymorphism is located in the N-terminal MYC transactivation domain and is highly conserved not only among most diverse species but also in the N-MYC homologue.	Asparagine	25-28	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	182-187
16102867-8	2005	The apparent Michaelis constants of the modified ASNase (K(m(app))=0.844 x 10(-3)mol L(-1)) was approximately six times lower than that of enzyme alone, which suggests that the affinity of the enzyme to substrate l-asparagine elevated when bioconjugated covalently with silk fibroin.	Asparagine	213-225	asparaginase and isoaspartyl peptidase 1	Homo sapiens	49-55
16027730-4	2005	Mutation of either of two TNFalpha-inducible serine residues (Ser460 and Ser471) to nonphosphorylatable residues (alanine, asparagine, phenylalanine) made REL more efficient at transforming chicken spleen cells in vitro.	Asparagine	123-133	lipopolysaccharide induced TNF factor	Gallus gallus	26-34
16300682-7	2005	On day two after birth, alanine, glycine, glutamine, glutamate, aspartate and asparagine were elevated in the blood of the PEPCK-C-/- mice and the blood urea nitrogen concentration was increased by 2-fold.	Asparagine	78-88	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	123-130
16274239-0	2005	Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor.	Asparagine	39-42	epidermal growth factor receptor	Mus musculus	54-86
16232313-5	2005	The extremely accelerated rates in the rbcL phylogeny correlated with a shift from selection to mutation drift in codon usage of two-fold degenerate NNY codons comprising the amino acids asparagine, aspartate, histidine, phenylalanine, and tyrosine.	Asparagine	187-197	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Cryptomonas paramecium	39-43
15943582-5	2005	Individual mutation of the ten histidine residues to asparagine in the catalytic domain of murine GPI-PLD resulted in three general phenotypes: not secreted or retained (His56 or His88), secreted with catalytic activity (His34, His81, His98 or His219) and secreted without catalytic activity (His29, His125, His133 or His158).	Asparagine	53-63	glycosylphosphatidylinositol specific phospholipase D1	Mus musculus	98-105
16129413-2	2005	D.Asn-Pro-(N-Me)Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH(2) (dNPA) displays a very high affinity (0.027nM) for NPFF(2) receptors transfected in CHO cells, and a very high selectivity with a discrimination ratio greater than 100 versus NPFF(1) receptors.	Asparagine	2-6	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	109-113
16129413-2	2005	D.Asn-Pro-(N-Me)Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH(2) (dNPA) displays a very high affinity (0.027nM) for NPFF(2) receptors transfected in CHO cells, and a very high selectivity with a discrimination ratio greater than 100 versus NPFF(1) receptors.	Asparagine	2-6	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	233-237
16129418-5	2005	We further conclude that residue 161, an Asn in QR2 and a His in QR1, is critical in differentiating the substrate specificities of these two enzymes.	Asparagine	41-44	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	48-51
16129418-5	2005	We further conclude that residue 161, an Asn in QR2 and a His in QR1, is critical in differentiating the substrate specificities of these two enzymes.	Asparagine	41-44	NAD(P)H quinone dehydrogenase 1	Homo sapiens	65-68
16224104-4	2005	In the lambda-repressor-DNA complex, the epsilon-NH(2) group (hydrogen bond donor) of lysine-4 of lambda-repressor forms hydrogen bonds with the amide carbonyl atom of asparagine-55 (acceptor) and the O6 (acceptor) of CG6 of operator site O(L)1.	Asparagine	168-178	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	201-244
16107341-3	2005	To enable disulfide-dependent and spontaneous formation of active Stat1 homodimer (as was done previously for Stat3), we engineered Stat1-CC with double-cysteine substitutions in the Src homology 2 (SH2)-homodimerization domain (at Ala-656 and Asn-658).	Asparagine	244-247	signal transducer and activator of transcription 1	Homo sapiens	66-71
16185272-5	2005	This permits classifying all HLA-C alleles into two functional groups: asparagine (N80) or lysine (K80) carrying alleles.	Asparagine	71-81	major histocompatibility complex, class I, C	Homo sapiens	29-34
15875186-6	2005	We further mutated the asparagine residues 418, 557 and 596 in three putative N-linked glycosylation motifs of BCRP to alanines.	Asparagine	23-33	ATP binding cassette subfamily G member 2	Canis lupus familiaris	111-115
16186382-2	2005	Random peptide phage display library screening for binding partners of GRP allowed the identification of an asparagine-leucine consensus motif.	Asparagine	108-118	glucokinase regulator	Homo sapiens	71-74
16186382-3	2005	Asparagine-leucine motifs of glucokinase located in the hinge region, as well as in the large domain, were changed by site-directed mutagenesis.	Asparagine	0-10	glucokinase	Homo sapiens	29-40
16135198-5	2005	Among all pre-treatment isolates, the dhfr triple mutation (Ile-51 + Arg-59 + Asn-108) was detected in 47%.	Asparagine	78-81	dihydrofolate reductase	Homo sapiens	38-42
16077958-8	2005	Asn-linked glycosylation site at codon 52 was conserved among mammalian Dkk2 orthologs; however, Asn-linked glycosylation site was not identified among mammalian Dkk4 orthologs.	Asparagine	0-3	dickkopf WNT signaling pathway inhibitor 2	Homo sapiens	72-76
16145474-3	2005	Two single nucleotide polymorphisms with nonsynonymous amino acid located at positions 9,402 (Arg/His) and 9,171 (Asn/Ser) in the OPN gene were genotyped using the TaqMan 5" nuclease assay in a PRISM 7700 sequence detection system.	Asparagine	114-117	secreted phosphoprotein 1	Homo sapiens	130-133
16023986-6	2005	The dhfr triple (Asn-108/Ile-51/Arg-59) mutants or the dhps double mutants (Gly-437/Glu-540) were independently associated with SP treatment failure in children aged less than 5 years, but not in older children.	Asparagine	17-20	dihydrofolate reductase	Homo sapiens	4-8
16144923-2	2005	We have studied the synonymous polymorphism that causes a single nucleotide change C to T at codon 118 converting a codon of common usage (AAC) to a less used codon (AAT), both coding asparagine.	Asparagine	184-194	glycine-N-acyltransferase	Homo sapiens	139-142
16144923-2	2005	We have studied the synonymous polymorphism that causes a single nucleotide change C to T at codon 118 converting a codon of common usage (AAC) to a less used codon (AAT), both coding asparagine.	Asparagine	184-194	serpin family A member 1	Homo sapiens	166-169
15901795-7	2005	Thus, the N-site asparagine (N) in the M2 region of the NR1 subunit represents the dominant site for uncompetitive antagonism by memantine.	Asparagine	17-27	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-59
15901795-8	2005	The N and N + 1 site asparagines in NR2A produce strong electrostatic interactions with memantine.	Asparagine	21-32	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	36-40
16101838-2	2005	This new DRB1 allele is identical to DRB1*1301 at exon 2 except for a single-nucleotide substitution at codon 37, changing the amino acid Asn to Asp.	Asparagine	138-141	major histocompatibility complex, class II, DR beta 1	Homo sapiens	9-13
16101838-2	2005	This new DRB1 allele is identical to DRB1*1301 at exon 2 except for a single-nucleotide substitution at codon 37, changing the amino acid Asn to Asp.	Asparagine	138-141	major histocompatibility complex, class II, DR beta 1	Homo sapiens	37-41
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Asparagine	115-125	hepsin	Homo sapiens	0-6
16011830-1	2005	One variant of the syndrome is linked to missense mutations that lead to a single amino-acid change (N588K; asparagine to lysine) in the S5-Pore linker region of the cardiac HERG K(+) channel.	Asparagine	108-118	potassium voltage-gated channel subfamily H member 2	Homo sapiens	174-178
15964838-2	2005	Here we report that mature Eag1 potassium channels carry sugar moieties linked to asparagines at positions 388 and 406.	Asparagine	82-93	potassium voltage-gated channel subfamily H member 1	Homo sapiens	27-31
15823095-9	2005	Of the five members, only Lass2, Lass5 and Lass6 were N-glycosylated, each at their N-terminal Asn residue.	Asparagine	95-98	ceramide synthase 2	Homo sapiens	26-31
16026410-1	2005	BACKGROUND: There are two known polymorphisms of clinical relevance in the follicle-stimulating hormone (FSH) receptor exon 10, alanine or threonine at position 307, and asparagine or serine at position 680, giving rise to two discrete allelic variants: Thr307/Asn680 and Ala307/Ser680.	Asparagine	170-180	follicle stimulating hormone receptor	Homo sapiens	75-118
15823095-9	2005	Of the five members, only Lass2, Lass5 and Lass6 were N-glycosylated, each at their N-terminal Asn residue.	Asparagine	95-98	ceramide synthase 5	Homo sapiens	33-38
15823095-9	2005	Of the five members, only Lass2, Lass5 and Lass6 were N-glycosylated, each at their N-terminal Asn residue.	Asparagine	95-98	ceramide synthase 6	Homo sapiens	43-48
15826241-0	2005	The N370S (Asn370--&gt;Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C. The properties of the endolysosomal enzyme GCase (glucosylceramidase), carrying the most prevalent mutation observed in Gaucher patients, namely substitution of an asparagine residue with a serine at amino acid position 370 [N370S (Asn370--&gt;Ser) GCase], were investigated in the present study.	Asparagine	318-328	glucosylceramidase beta	Homo sapiens	61-79
16060675-4	2005	Such side chain hydrogen bonding interactions have been called "polar zippers" by M. F. Perutz and have been proposed to stabilize amyloid fibrils formed by peptides with glutamine- and asparagine-rich sequences, such as Ure2p(10)(-)(39).	Asparagine	186-196	glutathione peroxidase	Saccharomyces cerevisiae S288C	221-226
16026410-2	2005	At position 680, three FSH receptor variants are possible: Asn/Asn, Asn/Ser, and Ser/Ser.	Asparagine	59-62	follicle stimulating hormone receptor	Homo sapiens	23-35
16026410-2	2005	At position 680, three FSH receptor variants are possible: Asn/Asn, Asn/Ser, and Ser/Ser.	Asparagine	63-66	follicle stimulating hormone receptor	Homo sapiens	23-35
16026410-2	2005	At position 680, three FSH receptor variants are possible: Asn/Asn, Asn/Ser, and Ser/Ser.	Asparagine	63-66	follicle stimulating hormone receptor	Homo sapiens	23-35
16026410-7	2005	RESULTS: The distribution of FSH receptor variants was Asn/Asn (AA) 35%, Asn/Ser (AS) 24%, and Ser/Ser (SS) 41%.	Asparagine	55-58	follicle stimulating hormone receptor	Homo sapiens	29-41
16026410-7	2005	RESULTS: The distribution of FSH receptor variants was Asn/Asn (AA) 35%, Asn/Ser (AS) 24%, and Ser/Ser (SS) 41%.	Asparagine	59-62	follicle stimulating hormone receptor	Homo sapiens	29-41
16026410-7	2005	RESULTS: The distribution of FSH receptor variants was Asn/Asn (AA) 35%, Asn/Ser (AS) 24%, and Ser/Ser (SS) 41%.	Asparagine	59-62	follicle stimulating hormone receptor	Homo sapiens	29-41
15964018-6	2005	Infection of primary CD4(+)T cells demonstrated that Env bearing Asp324 was less sensitive to RANTES, suggesting that Asp or Asn in this position may be crucial for viral fitness.	Asparagine	125-128	endogenous retrovirus group K member 20	Homo sapiens	53-56
15890659-1	2005	The peptide hormone angiotensin II (AngII) binds to the AT0 (angiotensin type 1) receptor within the transmembrane domains in an extended conformation, and its C-terminal residue interacts with transmembrane domain VII at Phe-293/Asn-294.	Asparagine	230-233	angiotensinogen	Homo sapiens	20-34
15890659-1	2005	The peptide hormone angiotensin II (AngII) binds to the AT0 (angiotensin type 1) receptor within the transmembrane domains in an extended conformation, and its C-terminal residue interacts with transmembrane domain VII at Phe-293/Asn-294.	Asparagine	230-233	angiotensinogen	Homo sapiens	36-41
15905212-3	2005	Swapping the divergent histidine (H107) residue in GlyR alpha1, which together with the conserved H109 forms part of an intersubunit Zn2+-binding site, for the equivalent asparagine residue present in GlyR alpha2 and alpha3, reversed this phenotype.	Asparagine	171-181	glycine receptor alpha 1	Homo sapiens	51-62
15964018-3	2005	Whereas gp120 subunits with Asp or Asn at position 324 were fusogenic with coreceptor chimeras containing either the N-terminal domain or the body of CCR5, substitution of charged (Glu, Lys) or small hydrophobic (Gly, Ala) residues resulted in complete loss of fusogenic activity with the N terminus and markedly reduced utilization of the body of CCR5, although their ability to use wild-type CCR5 was unchanged.	Asparagine	35-38	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	8-13
15964018-6	2005	Infection of primary CD4(+)T cells demonstrated that Env bearing Asp324 was less sensitive to RANTES, suggesting that Asp or Asn in this position may be crucial for viral fitness.	Asparagine	125-128	C-C motif chemokine ligand 5	Homo sapiens	94-100
15964018-7	2005	The CD4-dependent gp120 binding to CCR5 was decreased when Asp324 was replaced with a charged or hydrophobic residue, but unchanged when replaced with Asn.	Asparagine	151-154	CD4 molecule	Homo sapiens	4-7
15964018-7	2005	The CD4-dependent gp120 binding to CCR5 was decreased when Asp324 was replaced with a charged or hydrophobic residue, but unchanged when replaced with Asn.	Asparagine	151-154	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	18-23
15964018-7	2005	The CD4-dependent gp120 binding to CCR5 was decreased when Asp324 was replaced with a charged or hydrophobic residue, but unchanged when replaced with Asn.	Asparagine	151-154	C-C motif chemokine receptor 5	Homo sapiens	35-39
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Asparagine	36-39	CD4 molecule	Homo sapiens	170-173
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Asparagine	36-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	184-189
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Asparagine	36-39	C-C motif chemokine receptor 5	Homo sapiens	194-198
15824100-1	2005	In yeast, aggregation and toxicity of the expanded polyglutamine fragment of human huntingtin strictly depend on the presence of the endogenous self-perpetuating aggregated proteins (prions), which contain glutamine/asparagine-rich domains.	Asparagine	216-226	huntingtin	Homo sapiens	83-93
15980970-5	2005	Two previously described beta-catenin mutations in codon 33 TCT(Ser) &gt; TGT(Cys) and codon 37 TCT(Ser) &gt; TTT(Phe), whereas three novel mutations in codon 41 ACC(Thr) &gt; ATC(Ile), codon 33 TCT(Ser) &gt; TAT(Tyr) and codon 32 GAC(Asp) &gt; AAC(Asn) were observed.	Asparagine	249-252	catenin beta 1	Homo sapiens	25-37
15944803-9	2005	Two Asn-linked glycosylation sites were identified within zebrafish fgf11, but not within mammalian Fgf11 orthologs.	Asparagine	4-7	fibroblast growth factor 11a	Danio rerio	68-73
15985154-3	2005	RESULTS: Among 28 human tetraspanin proteins, the TM1-3 sequences display a distinct heptad repeat motif (abcdefg)n. In TM1, position a is occupied by structurally conserved bulky residues and position d contains highly conserved Asn and Gly residues.	Asparagine	230-233	tropomyosin 3	Homo sapiens	50-55
15799721-3	2005	Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM).	Asparagine	109-119	thyrotropin releasing hormone	Rattus norvegicus	68-71
15799721-3	2005	Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM).	Asparagine	109-119	thyrotropin releasing hormone	Rattus norvegicus	73-102
16014854-8	2005	However, the presence of the triple mutant dhfr (Ile-51/Arg-59/Asn-108) with the dhps Gly-437 genotype in all recurring infections, suggests the importance of codon 59 and 437 alleles in susceptibility to TRM/SMX.	Asparagine	63-66	dihydrofolate reductase	Homo sapiens	43-47
15863483-5	2005	Replacement of two acidic residues immediately after the GGGIG motif in skeletal muscle ryanodine receptor (RyR1-D4899 and -E4900) with asparagine and glutamine profoundly affected ion permeation and selectivity.	Asparagine	136-146	ryanodine receptor 1	Homo sapiens	72-106
15863483-5	2005	Replacement of two acidic residues immediately after the GGGIG motif in skeletal muscle ryanodine receptor (RyR1-D4899 and -E4900) with asparagine and glutamine profoundly affected ion permeation and selectivity.	Asparagine	136-146	ryanodine receptor 1	Homo sapiens	108-112
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	Asparagine	159-169	dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	4-8
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	Asparagine	159-169	dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	10-14
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	Asparagine	159-169	dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase	Saccharomyces cerevisiae S288C	20-25
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Asparagine	186-189	ubiquitin specific peptidase 7	Mus musculus	45-50
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Asparagine	186-189	ubiquitin specific peptidase 7	Mus musculus	52-58
15878871-10	2005	This study newly identifies residues Thr(173) and Asn(186) as important for the binding of CRP to FcgammaRIIa and FcgammaRI.	Asparagine	50-53	C-reactive protein	Homo sapiens	91-94
15878871-10	2005	This study newly identifies residues Thr(173) and Asn(186) as important for the binding of CRP to FcgammaRIIa and FcgammaRI.	Asparagine	50-53	Fc gamma receptor Ia	Homo sapiens	98-107
15907786-8	2005	Conservative mutations of the Asn-152 and Gln-155 residues inactivated the JNK3 enzyme, possibly interfering with protein folding in a critical hinge region of the protein.	Asparagine	30-33	mitogen-activated protein kinase 10	Homo sapiens	75-79
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Asparagine	10-13	zona pellucida glycoprotein 4	Homo sapiens	80-83
15938616-7	2005	The beta-strand B of Ca.CD2 that provides two Asp for the Ca(2+) undergoes an S(2) decrease upon the Ca(2+) binding, while the DE-loop that provides one Asn and one Asp undergoes an S(2) increase.	Asparagine	153-156	Cd2 molecule	Rattus norvegicus	21-27
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Asparagine	302-312	indolepyruvate decarboxylase 1	Saccharomyces cerevisiae S288C	103-107
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Asparagine	302-312	indolepyruvate decarboxylase 5	Saccharomyces cerevisiae S288C	109-113
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Asparagine	302-312	indolepyruvate decarboxylase 6	Saccharomyces cerevisiae S288C	115-119
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Asparagine	302-312	branched-chain-2-oxoacid decarboxylase THI3	Saccharomyces cerevisiae S288C	132-136
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Asparagine	302-312	phenylpyruvate decarboxylase ARO10	Saccharomyces cerevisiae S288C	144-149
15955065-5	2005	We changed either of the highly conserved aspartates, Asp28 and Asp506, in the N- and C-terminal signature sequences, respectively, of human PiT2 to asparagine and analyzed P(i) uptake function in Xenopus laevis oocytes.	Asparagine	149-159	solute carrier family 20 member 2	Homo sapiens	141-145
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Asparagine	10-13	zona pellucida glycoprotein 4	Homo sapiens	161-164
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Asparagine	240-243	zona pellucida glycoprotein 4	Homo sapiens	80-83
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Asparagine	240-243	zona pellucida glycoprotein 4	Homo sapiens	161-164
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Asparagine	115-125	Rab escort protein	Arabidopsis thaliana	192-198
15833284-5	2005	The heavy chains yielded post-translational modifications previously reported for other recombinant humanized or human IgG1 such as N-terminal pyroglutamic acid, C-terminal lysine clipping and N-glycosylation for asparagine 297.	Asparagine	213-223	LOC105243590	Mus musculus	119-123
15750626-6	2005	Investigation of both N-terminal and C-terminal (aa 727-826) oxygen-regulated proline and asparagine hydroxylation of HIF-1alpha revealed that both are inhibited during high cell density, as determined by impaired capture of HIF-1alpha by VHL and enhanced C-terminal transactivation.	Asparagine	90-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
15854657-3	2005	The membrane-spanning segment is based on MS1, a transmembrane coiled coil that contains a single Asn at a buried a position of a central heptad in its sequence.	Asparagine	98-101	MS	Homo sapiens	42-45
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Asparagine	115-125	Rab escort protein	Arabidopsis thaliana	161-164
15616123-1	2005	Human apolipoprotein B100 (apoB100) has 19 potential N-glycosylation sites, and 16 asparagine residues were reported to be occupied by high-mannose type, hybrid type, and monoantennary and biantennary complex type oligosaccharides.	Asparagine	83-93	apolipoprotein B	Homo sapiens	6-25
15853298-3	2005	Comparison with the ROA spectra of beta-lactoglobulin and N,N"-diacetylchitobiose reveals features consistent with previous suggestions that the peptide component of AGP has a structure based on the lipocalin fold, and that the first two glycosidic links after the N-links to asparagine in the pentasaccharide core are of the beta(1-4)-type.	Asparagine	276-286	alpha-1-acid glycoprotein	Bos taurus	166-169
15894658-7	2005	Among postmenopausal controls, blood SHBG levels were 10% higher in carriers of the variant Asn allele than noncarriers (P = 0.06).	Asparagine	92-95	sex hormone binding globulin	Homo sapiens	37-41
15894658-8	2005	Postmenopausal control women with the Asn allele and low BMI or waist-to-hip ratio had 20% higher SHBG levels (P &lt; 0.05).	Asparagine	38-41	sex hormone binding globulin	Homo sapiens	98-102
15616123-1	2005	Human apolipoprotein B100 (apoB100) has 19 potential N-glycosylation sites, and 16 asparagine residues were reported to be occupied by high-mannose type, hybrid type, and monoantennary and biantennary complex type oligosaccharides.	Asparagine	83-93	apolipoprotein B	Homo sapiens	27-34
15860005-2	2005	dgl1-1 is altered in a protein ortholog of human OST48 or yeast WBP1, an essential protein subunit of the oligosaccharyltransferase (OST) complex, which is responsible for the transfer in the ER of the N-linked glycan precursor onto Asn residues of candidate proteins.	Asparagine	233-236	dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit family protein	Arabidopsis thaliana	0-6
15806313-5	2005	Rat Wnt11 (354 aa) was a secreted protein with 24 conserved Cys residues and five Asn-linked glycosylation sites.	Asparagine	82-85	Wnt family member 11	Rattus norvegicus	4-9
15806313-7	2005	Comparative proteomics revealed that the number of Asn-linked glycosylation sites increased during molecular evolution of Wnt11 orthologs.	Asparagine	51-54	Wnt family member 11	Rattus norvegicus	122-127
15877619-4	2005	Molecular genetic studies of a patient with Brugada syndrome identified a novel mutation in SCN5A, which causes substitution of serine for asparagine (N406S) in S6 of domain I (IS6).	Asparagine	139-149	sodium voltage-gated channel alpha subunit 5	Homo sapiens	92-97
15809769-7	2005	Rat Wnt9a protein (365 aa) with N-terminal signal peptide, 24 Cys residues and one Asn-linked glycosylation site showed 100%, 98.1% and 82.5% total amino-acid identity with mouse Wnt9a, human WNT9A and chicken wnt9a, respectively.	Asparagine	83-86	Wnt family member 9A	Rattus norvegicus	4-9
15809770-7	2005	Two Asn-linked glycosylation sites within the N-terminal extracellular region were conserved among vertebrate Fzd8 orhologs.	Asparagine	4-7	frizzled class receptor 8	Homo sapiens	110-114
15809770-8	2005	One Asn-linked glycosylation site within the second extracellular loop was conserved among mammalian Fzd8 orthologs, but not in Xenopus and zebrafish fzd8 orthologs.	Asparagine	4-7	frizzled class receptor 8	Homo sapiens	101-105
15860005-2	2005	dgl1-1 is altered in a protein ortholog of human OST48 or yeast WBP1, an essential protein subunit of the oligosaccharyltransferase (OST) complex, which is responsible for the transfer in the ER of the N-linked glycan precursor onto Asn residues of candidate proteins.	Asparagine	233-236	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	49-54
15860005-2	2005	dgl1-1 is altered in a protein ortholog of human OST48 or yeast WBP1, an essential protein subunit of the oligosaccharyltransferase (OST) complex, which is responsible for the transfer in the ER of the N-linked glycan precursor onto Asn residues of candidate proteins.	Asparagine	233-236	dolichyl-diphosphooligosaccharide-protein glycotransferase	Saccharomyces cerevisiae S288C	64-68
15537386-3	2005	Molecular cloning of cgl GnTI cDNA revealed a point mutation, which causes a critical amino acid substitution (Asp144--&gt;Asn), thereby creating an additional N-glycosylation site.	Asparagine	123-126	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Arabidopsis thaliana	25-29
15723349-6	2005	This is induced by the replacement of a conserved Asp, Asn, or Glu residue by a Pro at one side of the N-Src loop.	Asparagine	55-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
15722344-3	2005	Using molecular dynamics simulations and site-directed mutagenesis techniques we have identified residue Asn-7.49, of the NPxxY motif of TM 7, as a molecular switch in the mechanism of thyrotropin receptor (TSHr) activation.	Asparagine	105-108	thyroid stimulating hormone receptor	Homo sapiens	185-205
15722344-3	2005	Using molecular dynamics simulations and site-directed mutagenesis techniques we have identified residue Asn-7.49, of the NPxxY motif of TM 7, as a molecular switch in the mechanism of thyrotropin receptor (TSHr) activation.	Asparagine	105-108	thyroid stimulating hormone receptor	Homo sapiens	207-211
15722344-8	2005	Upon receptor activation Asn-7.49 adopts the trans conformation to interact with Asp-2.50 and a putatively charged residue that remains to be identified.	Asparagine	25-28	beta-secretase 1	Homo sapiens	81-86
15722344-10	2005	As residues Leu-2.46, Asp-2.50, and Asn-7.49 are strongly conserved, this molecular mechanism of TSHr activation can be extended to other members of the rhodopsin-like family of G protein-coupled receptors.	Asparagine	36-39	thyroid stimulating hormone receptor	Homo sapiens	97-101
15722344-10	2005	As residues Leu-2.46, Asp-2.50, and Asn-7.49 are strongly conserved, this molecular mechanism of TSHr activation can be extended to other members of the rhodopsin-like family of G protein-coupled receptors.	Asparagine	36-39	rhodopsin	Homo sapiens	153-162
15537386-5	2005	Remarkably, introduction of the Asp144--&gt;Asn mutation into rabbit GnTI, which does not result in the formation of a new N-glycosylation site, led to a protein with strongly reduced, but still detectable enzymic activity.	Asparagine	44-47	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Oryctolagus cuniculus	69-73
15592895-1	2005	The dengue 2 virus (DENV-2) NS1 glycoprotein contains two potential sites for N-linked glycosylation at Asn-130 and Asn-207.	Asparagine	104-107	influenza virus NS1A binding protein	Homo sapiens	28-31
15797573-2	2005	PSA has one known posttranslational modification, a sialylated diantennary N-linked oligosaccharide attached to the asparagine residue N45.	Asparagine	116-126	kallikrein related peptidase 3	Homo sapiens	0-3
15807535-0	2005	N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.	Asparagine	61-71	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	52-57
15771721-2	2005	Two other SNPs (CRH A145G and C240G) occur in the propeptide region at residue positions 45 and 77, respectively, that result in serine/asparagine and histidine/aspartic acid substitutions respectively.	Asparagine	136-146	corticotropin releasing hormone	Bos taurus	16-19
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Asparagine	28-31	ribosomal protein S21	Homo sapiens	41-45
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Asparagine	28-31	ribosomal protein S21	Homo sapiens	106-143
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Asparagine	28-31	ribosomal protein S21	Homo sapiens	145-149
15592895-1	2005	The dengue 2 virus (DENV-2) NS1 glycoprotein contains two potential sites for N-linked glycosylation at Asn-130 and Asn-207.	Asparagine	116-119	influenza virus NS1A binding protein	Homo sapiens	28-31
15592895-9	2005	Immunofluorescent antibody staining of infected cells showed that for WT 16681 virus or the Asn-130 site mutant viruses NS1 was located throughout the cytoplasm, however, Asn-207 site mutant virus NS1 protein appeared to be localized to the perinuclear region.	Asparagine	92-95	influenza virus NS1A binding protein	Homo sapiens	120-123
15748721-7	2005	Twelve cysteine residues, forming six disulfide bonds within beta-subunit and two putative asparagine-linked glycosylation sites, are also conserved in the Chinese soft-shell turtle FSHbeta subunit.	Asparagine	91-101	follitropin subunit beta	Pelodiscus sinensis	182-189
15826505-0	2005	Asparagine-473 residue is important to the efficient function of human dihydrolipoamide dehydrogenase.	Asparagine	0-10	dihydrolipoamide dehydrogenase	Homo sapiens	71-101
16705796-3	2005	Among the enzymes regulating the post-translational modification of HIF-la, the factor inhibiting HIF-1 (FIH-1) hydroxylates the protein at asparagine 803, suppressing the interaction of HIF-1a with transcription coactivators p300/CBP and reducing the transcriptional activity of the protein.	Asparagine	140-150	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	80-103
16705796-3	2005	Among the enzymes regulating the post-translational modification of HIF-la, the factor inhibiting HIF-1 (FIH-1) hydroxylates the protein at asparagine 803, suppressing the interaction of HIF-1a with transcription coactivators p300/CBP and reducing the transcriptional activity of the protein.	Asparagine	140-150	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	105-110
16705796-3	2005	Among the enzymes regulating the post-translational modification of HIF-la, the factor inhibiting HIF-1 (FIH-1) hydroxylates the protein at asparagine 803, suppressing the interaction of HIF-1a with transcription coactivators p300/CBP and reducing the transcriptional activity of the protein.	Asparagine	140-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-193
16705796-3	2005	Among the enzymes regulating the post-translational modification of HIF-la, the factor inhibiting HIF-1 (FIH-1) hydroxylates the protein at asparagine 803, suppressing the interaction of HIF-1a with transcription coactivators p300/CBP and reducing the transcriptional activity of the protein.	Asparagine	140-150	E1A binding protein p300	Homo sapiens	226-230
16705796-3	2005	Among the enzymes regulating the post-translational modification of HIF-la, the factor inhibiting HIF-1 (FIH-1) hydroxylates the protein at asparagine 803, suppressing the interaction of HIF-1a with transcription coactivators p300/CBP and reducing the transcriptional activity of the protein.	Asparagine	140-150	CREB binding protein	Homo sapiens	231-234
15804608-4	2005	The deglycosylation reaction by PNGase brings about two major changes on substrate the peptide; one is removal of the N-glycan chain and the other is the introduction of a negative charge into the core peptide by converting the glycosylated asparagine residue(s) into an aspartic acid residue(s).	Asparagine	241-251	N-glycanase 1	Homo sapiens	32-38
15756456-7	2005	Rat Wnt16 (364 aa) with an N-terminal signal peptide, 24 Cys residues and 3 Asn-linked glycosylation sites showed 97.3, 90.4 and 65.9% total-amino-acid identity with mouse Wnt16, human WNT16, and zebrafish wnt16, respectively.	Asparagine	76-79	Wnt family member 16	Rattus norvegicus	4-9
15756457-6	2005	Rat Wnt7a (349 aa) with 24 Cys residues and 3 Asn-linked glycosylation sites showed 99.7, 99.1 and 93.7% total-amino- acid identity with mouse Wnt7a, human WNT7A and chicken wnt7a, respectively.	Asparagine	46-49	Wnt family member 7A	Rattus norvegicus	4-9
16233806-4	2005	Northern blot analysis suggested that asparagine and serine repress the expression of the PTR 2 gene, but lysine decreases the peptide transport activity without repressing PTR 2 gene transcription.	Asparagine	38-48	Ptr2p	Saccharomyces cerevisiae S288C	90-95
15741335-5	2005	Kinetic experiments show that deamidation of Asn 203 occurs at a rate of 0.023 h(-1) at 50 degrees C for Ca(2+)-free calbindin.	Asparagine	45-48	calbindin 1	Homo sapiens	117-126
15736973-0	2005	Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase.	Asparagine	77-87	glutamate dehydrogenase	Escherichia coli	137-160
15741231-5	2005	Additionally, the triadic His562 residue of LDLR, which is putatively involved in ligand uncoupling, was mutated to Asn, corresponding to Asn643 in LpR, to analyse the role of the His triad in receptor functioning.	Asparagine	116-119	low density lipoprotein receptor	Homo sapiens	44-48
15736939-12	2005	The mutation sensitivity of PLB Asn(34) and Leu(37) identifies a region of the protein that is responsible for this regulatory property.	Asparagine	32-35	phospholamban	Homo sapiens	28-31
15736973-1	2005	A mutant (D165N) of clostridial glutamate dehydrogenase (GDH) in which the catalytic Asp is replaced by Asn surprisingly showed a residual 2% of wild-type activity when purified after expression in Escherichia coli at 37 degrees C. This low-level activity also displayed Michaelis constants for substrates that were remarkably similar to those of the wild-type enzyme.	Asparagine	104-107	glutamate dehydrogenase	Escherichia coli	32-55
15736973-1	2005	A mutant (D165N) of clostridial glutamate dehydrogenase (GDH) in which the catalytic Asp is replaced by Asn surprisingly showed a residual 2% of wild-type activity when purified after expression in Escherichia coli at 37 degrees C. This low-level activity also displayed Michaelis constants for substrates that were remarkably similar to those of the wild-type enzyme.	Asparagine	104-107	glutamate dehydrogenase	Escherichia coli	57-60
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Asparagine	201-204	intercellular adhesion molecule 1	Homo sapiens	29-62
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Asparagine	201-204	intercellular adhesion molecule 1	Homo sapiens	64-70
15701688-5	2005	Ubiquitin binds to a hydrophobic and acidic patch on helices alpha1 and alpha2 of the GAT three-helix bundle that includes Asn-223, Leu-227, Glu-230, Met-231, Asp-244, Glu-246, Leu-247, Glu-250, and Leu-251.	Asparagine	123-126	adrenoceptor alpha 1D	Homo sapiens	61-78
15702249-7	2005	Rat Wnt6 gene, consisting of four exons, encoded a 365-aa protein with signal peptide, 24 conserved Cys residues, two Asn-linked glycosylation sites and an RGD motif.	Asparagine	118-121	Wnt family member 6	Rattus norvegicus	4-8
15702249-8	2005	Rat Wnt10a gene, consisting of four exons, encoded a 417-aa protein with 24 conserved Cys residues, two Asn-linked glycosylation sites and an RGD motif.	Asparagine	104-107	Wnt family member 10A	Rattus norvegicus	4-10
15809331-12	2005	Thus, Ser(124), His(145) and Asn(196) may be critical for the catalytic function of GDH.	Asparagine	29-32	lambda-crystallin	Oryctolagus cuniculus	84-87
15703844-5	2005	Rat Wnt1 gene, consisting of four exons, encoded a 370-aa protein with signal peptide, 22 conserved Cys residues and four Asn-linked glycosylation sites.	Asparagine	122-125	Wnt family member 1	Rattus norvegicus	4-8
15703844-6	2005	Rat Wnt10b gene, consisting of five exons, encoded a 389-aa protein with signal peptide, 24 conserved Cys residues and two Asn-linked glycosylation sites.	Asparagine	123-126	Wnt family member 10B	Rattus norvegicus	4-10
15809331-9	2005	Furthermore, we examined the roles of Asp(36), Ser(124), His(145), Glu(157 )and Asn(196) in the catalytic function of rabbit GDH by site-directed mutagenesis.	Asparagine	80-83	lambda-crystallin	Oryctolagus cuniculus	125-128
15598653-8	2005	Also, alteration of the Ile-144 and Ile-86 residues to the corresponding residues found in the homologous Imp1 protease changes the specificity to promote cleavage following a -1 Asn residue.	Asparagine	179-182	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	106-110
15572376-6	2005	Unique residues within helices 3 (Ile(164) and Asn(165)), 5 (Cys(202) and His(203)), and 7 (Phe(234) and Phe(238)) were found control the selectivity for CAR activators and inhibitors.	Asparagine	47-50	nuclear receptor subfamily 1 group I member 3	Homo sapiens	154-157
15701688-5	2005	Ubiquitin binds to a hydrophobic and acidic patch on helices alpha1 and alpha2 of the GAT three-helix bundle that includes Asn-223, Leu-227, Glu-230, Met-231, Asp-244, Glu-246, Leu-247, Glu-250, and Leu-251.	Asparagine	123-126	glycine-N-acyltransferase	Homo sapiens	86-89
15664654-4	2005	Site-directed mutagenesis was carried out on Bm-CPI-2 at Asn-77, the residue on which AEP inhibition is dependent in vertebrate homologues.	Asparagine	57-60	Cystatin cpi-2	Caenorhabditis elegans	48-53
15671159-5	2005	Uniquely, all known mammalian orthologs of AQP6 have an asparagine residue (Asn-60) at the position corresponding to Gly-57.	Asparagine	56-66	aquaporin 6	Homo sapiens	43-47
15671159-5	2005	Uniquely, all known mammalian orthologs of AQP6 have an asparagine residue (Asn-60) at the position corresponding to Gly-57.	Asparagine	76-79	aquaporin 6	Homo sapiens	43-47
15671159-8	2005	We propose that the asparagine residue at the contact point between TM2 and TM5 in AQP6 may function as a teeter board needed for rapid structural oscillations during anion permeation.	Asparagine	20-30	tropomyosin 3	Homo sapiens	76-79
15671159-8	2005	We propose that the asparagine residue at the contact point between TM2 and TM5 in AQP6 may function as a teeter board needed for rapid structural oscillations during anion permeation.	Asparagine	20-30	aquaporin 6	Homo sapiens	83-87
15670167-10	2005	Using this KH1-KH2 construct we explicitly test a hypothesis that has been proposed to explain the effect of the Ile--&gt;Asn mutation: that it causes complete unfolding of the protein.	Asparagine	122-125	DEAD box protein 21E2	Drosophila melanogaster	11-14
15670167-10	2005	Using this KH1-KH2 construct we explicitly test a hypothesis that has been proposed to explain the effect of the Ile--&gt;Asn mutation: that it causes complete unfolding of the protein.	Asparagine	122-125	KH2	Drosophila melanogaster	15-18
15629119-6	2005	Instead, we suggest that the conserved Glu, Lys, and Asn residues of the N-box contribute to coordinating Mg2+ in a position critical for formation of the PDK-MgATP-substrate ternary complex.	Asparagine	53-56	pyruvate dehydrogenase kinase	Arabidopsis thaliana	155-158
15629124-6	2005	The iron ligands of soybean lipoxygenase-1 are two His residues in the sequence HWLNTH, one His residue and a distant Asn residue in the sequence HAAVNFGQ, and the C-terminal Ile residue.	Asparagine	118-121	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
15542553-8	2005	Furthermore, SBA is a glycoprotein with a GlcNac2Man9 chain attached to Asn-75 of each subunit.	Asparagine	72-75	lectin	Glycine max	13-16
15507441-12	2005	Based on these studies, we conclude that N-glycosylation of Stt3p at Asn(539) is essential for its function in the OT complex.	Asparagine	69-72	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	60-65
15607727-0	2005	Three-dimensional structure prediction of bovine AP lyase, BAP1: prediction of interaction with DNA and alterations as a result of Arg176--&gt;Ala, Asp282--&gt;Ala, and His308--&gt;Asn mutations.	Asparagine	181-184	apurinic/apyrimidinic endodeoxyribonuclease 1	Bos taurus	49-57
15607727-0	2005	Three-dimensional structure prediction of bovine AP lyase, BAP1: prediction of interaction with DNA and alterations as a result of Arg176--&gt;Ala, Asp282--&gt;Ala, and His308--&gt;Asn mutations.	Asparagine	181-184	BRCA1 associated protein 1	Bos taurus	59-63
15581601-4	2005	In this report, we propose that three more residues in 15-PGDH, Ile-17, Asn-91, and Val-186, are also involved in the interaction with NAD(+).	Asparagine	72-75	carbonyl reductase 1	Homo sapiens	55-62
15533938-3	2005	In MMP-8, the neutrophil collagenase, a conserved Gly at the S(3)" substrate specificity subsite is replaced by Asn(188) that forms a highly unusual cis bond with Tyr(189), a conserved active site residue in the collagenases.	Asparagine	112-115	matrix metallopeptidase 8	Homo sapiens	3-8
15533938-3	2005	In MMP-8, the neutrophil collagenase, a conserved Gly at the S(3)" substrate specificity subsite is replaced by Asn(188) that forms a highly unusual cis bond with Tyr(189), a conserved active site residue in the collagenases.	Asparagine	112-115	matrix metallopeptidase 8	Homo sapiens	14-36
15581601-14	2005	These results suggest that Ile-17, Asn-91, and Val-186 are involved in the interaction with NAD(+) and contribute to the full catalytic activity of 15-PGDH.	Asparagine	35-38	carbonyl reductase 1	Homo sapiens	148-155
15634012-5	2005	Reliability of the CCK1R model was confirmed by interaction networks that involved conserved and functionally crucial motifs in G-protein-coupled receptors, such as Glu/Asp-Arg-Tyr and Asn-Pro-Xaa-Xaa-Tyr motifs.	Asparagine	185-188	cholecystokinin A receptor	Homo sapiens	19-24
15491997-5	2005	Initially, a second generation antibody phage-display library targeting a germline hot spot (Ser(30)-Asn(31)) within CDR1 of the antibody light chain was mutated.	Asparagine	101-104	cerebellar degeneration related protein 1	Homo sapiens	117-121
16217922-13	2005	An interesting observation is the reduction of DNA damage for workers with high VCM exposure and possessing the XPD Asp/Asn and Asn/Asn genotypes (OR 0.33, 95% CI 0.11-0.95).	Asparagine	120-123	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	112-115
15609295-6	2005	DNA sequencing analysis showed the patient to be a compound heterozygote for two mutations in the GPIX gene, a novel nine-nucleotide deletion starting at position 1952 of the gene that changes asparagine 86 for alanine and eliminates amino acids 87, 88, and 89 (arginine, threonine, and proline) and a previously reported point mutation that changes the codon asparagine (AAC) for serine (AGC) at residue 45.	Asparagine	193-203	glycoprotein IX platelet	Homo sapiens	98-102
15952883-4	2005	In addition, the HIFalpha transcriptional activation function is modulated further by asparagine hydroxylation by FIH (factor-inhibiting HIF), which affects recruitment of the coactivators p300 and CBP.	Asparagine	86-96	E1A binding protein p300	Homo sapiens	189-193
15952883-4	2005	In addition, the HIFalpha transcriptional activation function is modulated further by asparagine hydroxylation by FIH (factor-inhibiting HIF), which affects recruitment of the coactivators p300 and CBP.	Asparagine	86-96	CREB binding protein	Homo sapiens	198-201
15385420-4	2005	We discovered a polymorphism in exon 2 of the porcine TBG gene that results in an amino acid change of the consensus histidine to an asparagine.	Asparagine	133-143	serpin family A member 7	Homo sapiens	54-57
15385420-6	2005	Binding studies indicate altered binding characteristics of the allelic variants of TBG with the asparagine (White Composite) isoform having significantly greater affinity for thyroxine than the histidine (Meishan) isoform.	Asparagine	97-107	serpin family A member 7	Homo sapiens	84-87
15651853-2	2005	In previous studies, we determined the importance of an active site amino acid (asparagine 169) in the recognition of substrates by AAG.	Asparagine	80-90	N-methylpurine DNA glycosylase	Homo sapiens	132-135
15700423-5	2005	The functionality of TaASN1 was demonstrated by complementing an Escherichia coli asparagine auxotroph.	Asparagine	82-92	asparagine synthetase [glutamine-hydrolyzing]	Triticum aestivum	21-27
15456777-4	2004	Plasmids encoding wild type Cdc42 or a dominant negative Cdc42 mutant, Asn-17 Cdc42, were introduced into tracheal smooth muscle strips by reversible permeabilization, and tissues were incubated for 2 days to allow for protein expression.	Asparagine	71-74	cell division cycle 42	Homo sapiens	57-62
15634267-6	2005	Sequence analysis of the patient"s cDNA indicated a new missense mutation that led to the amino acid substitution of Ile304 (ATC) with Asn (AAC) in exon 6 of the beta3 gene.	Asparagine	135-138	glycine-N-acyltransferase	Homo sapiens	140-143
15634267-6	2005	Sequence analysis of the patient"s cDNA indicated a new missense mutation that led to the amino acid substitution of Ile304 (ATC) with Asn (AAC) in exon 6 of the beta3 gene.	Asparagine	135-138	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	162-167
15634267-8	2005	The missense mutation of Ile304 (ATC) to Asn (AAC) in beta3 was found to be responsible for this GT case.	Asparagine	41-44	glycine-N-acyltransferase	Homo sapiens	46-49
15634267-8	2005	The missense mutation of Ile304 (ATC) to Asn (AAC) in beta3 was found to be responsible for this GT case.	Asparagine	41-44	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	54-59
15456750-1	2004	A single nucleotide polymorphism that results in substitution at residue 700 of a serine (Ser-700) for an asparagine (Asn-700) in thrombospondin-1 is associated with familial premature coronary artery disease.	Asparagine	118-121	thrombospondin 1	Homo sapiens	130-146
15456750-6	2004	Intrinsic fluorescence of a tryptophan at residue 698 (Trp-698) in the most N-terminal motif was cooperatively quenched by the addition of Ca2+ to Asn-700 Tr2, Tr3, and Tr4 constructs.	Asparagine	147-150	nuclear receptor subfamily 2 group C member 1	Homo sapiens	155-158
15456777-4	2004	Plasmids encoding wild type Cdc42 or a dominant negative Cdc42 mutant, Asn-17 Cdc42, were introduced into tracheal smooth muscle strips by reversible permeabilization, and tissues were incubated for 2 days to allow for protein expression.	Asparagine	71-74	cell division cycle 42	Homo sapiens	57-62
15456750-6	2004	Intrinsic fluorescence of a tryptophan at residue 698 (Trp-698) in the most N-terminal motif was cooperatively quenched by the addition of Ca2+ to Asn-700 Tr2, Tr3, and Tr4 constructs.	Asparagine	147-150	nuclear receptor subfamily 2 group C member 2	Homo sapiens	169-172
15385533-1	2004	Expression of human asparagine synthetase (ASNS), which catalyzes asparagine and glutamate biosynthesis, is transcriptionally induced following amino acid deprivation.	Asparagine	20-30	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	43-47
15522226-5	2004	Site-directed mutagenesis showed both Asn-663 and Asn-748 to be N-glycosylated in mouse WFS1 protein.	Asparagine	38-41	wolframin ER transmembrane glycoprotein	Mus musculus	88-92
15522226-5	2004	Site-directed mutagenesis showed both Asn-663 and Asn-748 to be N-glycosylated in mouse WFS1 protein.	Asparagine	50-53	wolframin ER transmembrane glycoprotein	Mus musculus	88-92
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Asparagine	158-161	matrix metallopeptidase 14	Homo sapiens	188-195
15557261-4	2004	The ASM model predicts residues Asp 206, Asp 278, Asn 318, His 425, and His 457 to be dimetal coordinating.	Asparagine	50-53	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Asparagine	158-161	complement C1q A chain	Homo sapiens	238-241
15239670-4	2004	FIH hydroxylates a conserved asparagine residue in HIF-alpha (Asn-803), which blocks the binding of HIF to the transcriptional co-activator p300, preventing transcription of hypoxia-regulated genes under normoxic conditions.	Asparagine	29-39	E1A binding protein p300	Homo sapiens	140-144
15476678-12	2004	Within receptor constructs of combined domain exchanges the additional substitution of Tyr(110) by the corresponding Asn from the P2Y(6) receptor showed a significant increase for activation by UDP, but only when combined with the N-terminal domain and TM1.	Asparagine	117-120	pyrimidinergic receptor P2Y6	Homo sapiens	130-145
15491611-7	2004	Molecular modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which are substituted in ELI with Glu, Asn, and Ile, respectively.	Asparagine	142-145	serine and arginine rich splicing factor 1	Homo sapiens	67-70
15491611-7	2004	Molecular modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which are substituted in ELI with Glu, Asn, and Ile, respectively.	Asparagine	142-145	S100 calcium binding protein B	Homo sapiens	71-74
15239670-4	2004	FIH hydroxylates a conserved asparagine residue in HIF-alpha (Asn-803), which blocks the binding of HIF to the transcriptional co-activator p300, preventing transcription of hypoxia-regulated genes under normoxic conditions.	Asparagine	62-65	E1A binding protein p300	Homo sapiens	140-144
15632312-5	2004	Among them, three mAbs that strongly reacted with yeast Hsc82 recognized Asn(291)-Ile(304), a conserved region of the family protein.	Asparagine	73-76	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	56-61
15546195-1	2004	The cDNA encoding human cystatin C (HCC) was subjected to site-specific substitution of alanine for serine at the position 37, to obtain the Asn(35)-Lys(36)-Ser(37) sequence that is a signal for asparagine-linked (N-linked) glycosylation of protein in eukaryotes, and was transformed into Pichia pastoris X33.	Asparagine	141-144	cystatin C	Homo sapiens	24-34
15546195-1	2004	The cDNA encoding human cystatin C (HCC) was subjected to site-specific substitution of alanine for serine at the position 37, to obtain the Asn(35)-Lys(36)-Ser(37) sequence that is a signal for asparagine-linked (N-linked) glycosylation of protein in eukaryotes, and was transformed into Pichia pastoris X33.	Asparagine	195-205	cystatin C	Homo sapiens	24-34
15542393-7	2004	The intracellular human NPC2 protein occurred as two N-glycosylated forms, with either one single oligosaccharide chain attached to Asn 58 or two oligosaccharides attached to Asn 58 and 135.	Asparagine	132-135	NPC intracellular cholesterol transporter 2	Homo sapiens	24-28
15342690-11	2004	The Asn-373 mutant demonstrated a 3-fold decrease in bridging compared with wild-type EL, whereas Asn-116 and Asn-471 were similar to wild-type EL.	Asparagine	4-7	lipase G, endothelial type	Homo sapiens	86-88
15306657-3	2004	We found that two residues that directly contact TRH, Asn-110 in transmembrane helix 3 (3.37) and Arg-306 in transmembrane helix 7 (7.39), were important for midazolam binding but another, Tyr-282 in transmembrane helix 6 (6.51), was not.	Asparagine	54-57	thyrotropin releasing hormone	Homo sapiens	49-52
15320781-2	2004	Two forms of alpha2AP circulate in human plasma: a 464-residue protein with methionine as the amino-terminus (Met-alpha2AP) and an N-terminally-shortened 452-residue form with asparagine as the amino-terminus (Asn-alpha2AP).	Asparagine	176-186	serpin family F member 2	Homo sapiens	13-21
15292263-4	2004	Recently it was proposed that RapGAP provides a catalytic Asn, which substitutes for the Gln found in all other Ras-like proteins (Daumke, O., Weyand, M., Chakrabarti, P. P., Vetter, I. R., and Wittinghofer, A.	Asparagine	58-61	RAP1 GTPase activating protein	Homo sapiens	30-36
15272021-7	2004	The mutation of one of the two glycosylated residues of PlGF, Asn-84, generates a PlGF variant with reduced binding activity.	Asparagine	62-65	placental growth factor	Homo sapiens	56-60
15272021-7	2004	The mutation of one of the two glycosylated residues of PlGF, Asn-84, generates a PlGF variant with reduced binding activity.	Asparagine	62-65	placental growth factor	Homo sapiens	82-86
15389122-0	2004	A novel mutation (deletion of Aalpha-Asn 80) in an abnormal fibrinogen: fibrinogen Caracas VI.	Asparagine	37-40	fibrinogen beta chain	Homo sapiens	60-70
15389122-0	2004	A novel mutation (deletion of Aalpha-Asn 80) in an abnormal fibrinogen: fibrinogen Caracas VI.	Asparagine	37-40	fibrinogen beta chain	Homo sapiens	72-82
15389122-9	2004	DNA sequencing of the propositus and his mother revealed a new unique point mutation that gives rise to a fibrinogen molecule with a missing amino acid residue at Aalpha-Asn 80.	Asparagine	170-173	fibrinogen beta chain	Homo sapiens	106-116
15351882-4	2004	The deduced Dictyostelium cdc25 protein (Dd-cdc25) has the highest molecular mass (109.9 kDa) in several cdc25 species so far reported and contains four regions consisting of unusually long asparagine repeats (22-31) in the sequence.	Asparagine	190-200	cell division cycle 25C	Homo sapiens	26-31
15351882-4	2004	The deduced Dictyostelium cdc25 protein (Dd-cdc25) has the highest molecular mass (109.9 kDa) in several cdc25 species so far reported and contains four regions consisting of unusually long asparagine repeats (22-31) in the sequence.	Asparagine	190-200	cell division cycle 25C	Homo sapiens	44-49
15351882-4	2004	The deduced Dictyostelium cdc25 protein (Dd-cdc25) has the highest molecular mass (109.9 kDa) in several cdc25 species so far reported and contains four regions consisting of unusually long asparagine repeats (22-31) in the sequence.	Asparagine	190-200	cell division cycle 25C	Homo sapiens	44-49
15231870-10	2004	Our results demonstrate that the binding site residues at position lysine 74 in mGluR4, glutamine 58 in mGluR6, and asparagine 74 in mGluR7 are key determinants of agonist affinity and that additional residues situated outside of the binding pocket, including those present in the extreme amino terminus, also contribute to agonist affinity and the pharmacological profiles of the group III mGluRs.	Asparagine	116-126	glutamate receptor, ionotropic, kainate 3	Mus musculus	133-139
15375526-11	2004	Membrane topology and extracellular loop containing three Cys residues and one Asn-linked glycosylation site were evolutionarily conserved among mammalian CDC50 homologs and yeast Cdc50p homologs.	Asparagine	79-82	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	155-160
15375526-11	2004	Membrane topology and extracellular loop containing three Cys residues and one Asn-linked glycosylation site were evolutionarily conserved among mammalian CDC50 homologs and yeast Cdc50p homologs.	Asparagine	79-82	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	180-186
15374944-6	2004	FLT3 proteins mutated at Ala-627, Asn-676, or Phe-691 remained sensitive to higher concentrations of the inhibitors, but the G697R mutation conferred high-level resistance to each of these inhibitors as well as to six additional experimental inhibitors.	Asparagine	34-37	fms related receptor tyrosine kinase 3	Homo sapiens	0-4
15327950-5	2004	Surprisingly, the binding hot spot on IL-22 includes asparagine 54 (N54), which is post-translationally modified by N-linked glycosylation.	Asparagine	53-63	interleukin 22	Homo sapiens	38-43
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Asparagine	97-107	Ras homolog, mTORC1 binding	Homo sapiens	64-68
15312251-7	2004	Informative single nucleotide polymorphisms (SNPs), including a G1181C SNP, which predicts a lysine-asparagine substitution at codon 3 of the OPG signal peptide and haplotypes, were related to the presence of PDB in 312 cases compared with 378 controls and to transmission of PDB in 140 affected offspring from 66 kindreds with familial PDB.	Asparagine	100-110	TNF receptor superfamily member 11b	Homo sapiens	142-145
15205742-8	2004	Three intronic base pair changes, one new sequence variation and two known polymorphisms were detected, including the GAT/GAC heterozygous state at codon Asn 164 in 15 (24%) of the analyzed patients.	Asparagine	154-157	glycine-N-acyltransferase	Homo sapiens	118-121
15205742-9	2004	This suggests that GAT/GAC heterozygous state at codon Asn 164 is associated with an earlier onset of disease.	Asparagine	55-58	glycine-N-acyltransferase	Homo sapiens	19-22
15308721-4	2004	We demonstrate that these antibodies discriminate the PrP monoglycosylated species, since two of them recognize molecules that have the first Asn glycosylation site occupied (mono1) while the other two recognize molecules glycosylated at the second site (mono2).	Asparagine	142-145	major prion protein	Ovis aries	54-57
15340059-6	2004	In addition, we identified asparagine residues essential for TSC2 GAP activity.	Asparagine	27-37	TSC complex subunit 2	Homo sapiens	61-65
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Asparagine	97-107	TSC complex subunit 2	Homo sapiens	51-55
15359084-6	2004	Recent site-directed mutagenesis has revealed that these inhibitors possess some molecular determinants (Phe-213, Val-227, Tyr-228, Gly-833, and Asn-839) for interaction with NCX1.	Asparagine	145-148	solute carrier family 8 member A1	Homo sapiens	175-179
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Asparagine	97-107	TSC complex subunit 2	Homo sapiens	74-78
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Asparagine	97-107	RAS p21 protein activator 1	Homo sapiens	155-162
15265078-5	2004	This nucleotide transversion results in an alteration of codon 299 from AAC to ATC, which leads to a change from asparagine (Asn) to isoleucine (Ile) in the POU domain of POU1F1.	Asparagine	113-123	POU class 1 homeobox 1	Gallus gallus	171-177
15277679-8	2004	Reverse genetic studies implicated a Ser --&gt; Asn substitution in the E2 envelope glycoprotein as the major determinant of the increased vector infectivity phenotype.	Asparagine	48-51	endogenous retrovirus group K member 20	Homo sapiens	75-96
15199058-2	2004	We have previously identified the importance of amino acid residues in the A-B loop of the Cepsilon3 domain of human IgE and implicated a region close to the glycosylation site at asparagine 371 as contributing to IgE-CD23 interaction.	Asparagine	180-190	immunoglobulin heavy constant epsilon	Homo sapiens	214-217
15199058-2	2004	We have previously identified the importance of amino acid residues in the A-B loop of the Cepsilon3 domain of human IgE and implicated a region close to the glycosylation site at asparagine 371 as contributing to IgE-CD23 interaction.	Asparagine	180-190	Fc epsilon receptor II	Homo sapiens	218-222
15304595-2	2004	The authors previously reported a rare polymorphism at codon 171 (Asn--&gt;Ser) of human Prnp to be associated with mesial temporal lobe epilepsy related to hippocampal sclerosis.	Asparagine	66-69	prion protein	Homo sapiens	89-93
15265078-5	2004	This nucleotide transversion results in an alteration of codon 299 from AAC to ATC, which leads to a change from asparagine (Asn) to isoleucine (Ile) in the POU domain of POU1F1.	Asparagine	125-128	POU class 1 homeobox 1	Gallus gallus	171-177
15245427-4	2004	The heterozygous mutation in codon 42, AAC&gt;AAG, changes asparagine to lysine (N14K).	Asparagine	59-69	glycine-N-acyltransferase	Homo sapiens	39-42
15299065-2	2004	METHODS: Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer.	Asparagine	146-156	vasoactive intestinal peptide	Homo sapiens	40-43
15299065-2	2004	METHODS: Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer.	Asparagine	146-156	vasoactive intestinal peptide	Homo sapiens	142-145
15299065-2	2004	METHODS: Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer.	Asparagine	158-161	vasoactive intestinal peptide	Homo sapiens	40-43
15282319-2	2004	The amino-terminal prion domain of Ure2p is necessary and sufficient for prion formation and has a high glutamine (Q) and asparagine (N) content.	Asparagine	122-132	glutathione peroxidase	Saccharomyces cerevisiae S288C	35-40
15236321-5	2004	Both rat spetex-1 and the mouse homologue contained Ser-X (X = His, Arg, or Asn) repeats in the middle portion of the proteins.	Asparagine	76-79	spermatogenesis associated 18	Rattus norvegicus	9-17
14984367-4	2004	These enzymes are oxygen-, iron- and 2-oxoglutarate-dependent dioxygenases that hydroxylate key proline and asparagine residues in HIFalpha subunits.	Asparagine	108-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-139
15260484-10	2004	In contrast, elimination of the polar character of the residue at position 590 (Asn in the wild-type protein) uniformly impaired the ability of MRP1 to transport potential physiological substrates and to confer resistance to three different classes of natural product drugs.	Asparagine	80-83	ATP binding cassette subfamily B member 1	Homo sapiens	144-148
15264876-3	2004	A second analogue, DOTA-R1,4,F19-STh(1-19), differs from the first in that asparagine residues in positions 1 and 4 have been altered to arginine residues in order to examine the effect of positively charged groups in the linker domain.	Asparagine	75-85	saitohin	Homo sapiens	33-36
15264876-4	2004	A third analogue, DOTA-11AUN-F19-STh(1-19), differs from the first in that it incorporates an 11-aminoundecanoic acid spacer group between the DOTA group and the first asparagine residue.	Asparagine	168-178	saitohin	Homo sapiens	33-36
15087452-3	2004	The deduced 371-amino-acid sequence shares 68% identity with human CtsW and includes the conserved catalytic triad cysteine, histidine, and asparagine found in all members of this family.	Asparagine	140-150	cathepsin W	Homo sapiens	67-71
15030318-2	2004	In this study we have identified Ser-304 (Phe301-Asp-His-Ser304-Pro-Asn-Lys307) as a major TCPTP phosphory-lation site and demonstrate that TC45, but not TC48, is phosphorylated on this site in vivo.	Asparagine	68-71	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	91-96
15150415-5	2004	Moreover, an asparagine residue, N116, strictly conserved within Sir2 proteins and shown to be essential for nicotinamide exchange, is in position to stabilize the oxocarbenium intermediate that has been proposed to proceed the hydrolysis of nicotinamide.	Asparagine	13-23	sirtuin 1	Homo sapiens	65-69
15039446-7	2004	Furthermore, the results presented indicate that residues in the second peptide (Glu-64, Asn-65, and Ile-68) participate in IL-2Rbeta recruitment.	Asparagine	89-92	interleukin 2 receptor subunit beta	Homo sapiens	124-133
15157149-5	2004	Indeed, replacing specific residues in the transmembrane helix of either alphaIIb or beta3 with an asparagine residue resulted in a facilitated homo-oligomerization of the mutated transmembrane helix, promoted the formation of integrin clusters on the cell surface and shifted alphaIIbbeta3 to its activated state.	Asparagine	99-109	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	85-90
15223302-6	2004	On the basis of secondary structure predictions, it was hypothesized that the amino acid motifs Pro-Ile-Gly of mUcnII and Pro-Thr-Asn of mUcnIII decrease alpha-helicity and thereby impair binding to CRF1.	Asparagine	130-133	corticotropin releasing hormone receptor 1	Homo sapiens	199-203
15194494-4	2004	Here the D(69) of a V5-tagged mouse CLR has been mutated to Ala (A), Glu (E), and Asn (N).	Asparagine	82-85	calcitonin receptor	Mus musculus	36-39
15256704-6	2004	Docked paclitaxel was found to form a hydrogen bond with the side chain of Asn 99, which is a characteristic residue of CYP2C8 and is located in the additional pocket.	Asparagine	75-78	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	120-126
15170345-10	2004	To thoroughly understand the importance of this entire region, the work described here investigates the contribution of ApB residues Asn-16, Thr-17, and Ser-19 to toxin affinity and isoform selectivity.	Asparagine	133-136	arginyl aminopeptidase	Homo sapiens	120-123
15163335-7	2004	RESULTS: A heterozygous germline mutation of the TSHR gene resulting in the substitution of serine (AGC) by asparagine (AAC) at codon 505 (S505N) was found, which co-segregated with thyrotoxicosis in the family.	Asparagine	108-118	thyroid stimulating hormone receptor	Homo sapiens	49-53
15163335-7	2004	RESULTS: A heterozygous germline mutation of the TSHR gene resulting in the substitution of serine (AGC) by asparagine (AAC) at codon 505 (S505N) was found, which co-segregated with thyrotoxicosis in the family.	Asparagine	108-118	glycine-N-acyltransferase	Homo sapiens	120-123
14751930-2	2004	There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version with Asn as the N-terminus, Asn-alpha2AP.	Asparagine	168-171	serpin family F member 2	Homo sapiens	32-40
15158327-9	2004	Sequence analysis of hepcidin amplicons from DBA/2N mice predicted an Asn--&gt;Lys substitution at position 73 of the HAMP peptide and a Ser--&gt;Phe substitution at position 76 of the HAMP2 peptide.	Asparagine	70-73	hepcidin antimicrobial peptide	Mus musculus	21-29
14993226-6	2004	Subsequently, we determined the first x-ray crystal structures of human GlcAT-P, in the absence and presence of a donor substrate product UDP, catalytic Mn(2+), and an acceptor substrate analogue N-acetyllactosamine (Galbeta1-4GlcNAc) or an asparagine-linked biantennary nonasaccharide.	Asparagine	241-251	beta-1,3-glucuronyltransferase 1	Homo sapiens	72-79
15215512-9	2004	Taken together, our results suggest the existence of a GS1/AS pathway representing a metabolic route for transferring ammonium released from protein catabolism into asparagine, an amino acid that may have a major role in nitrogen mobilization from diseased tissues.	Asparagine	165-175	glutamine synthetase	Solanum lycopersicum	55-58
15215512-9	2004	Taken together, our results suggest the existence of a GS1/AS pathway representing a metabolic route for transferring ammonium released from protein catabolism into asparagine, an amino acid that may have a major role in nitrogen mobilization from diseased tissues.	Asparagine	165-175	asparagine synthetase	Solanum lycopersicum	59-61
14990577-4	2004	A variety of structural alignment methods were applied and four highly conserved residues of human glutathione synthetase (Glu-144, Asn-146, Lys-305, and Lys-364) were identified in the binding site.	Asparagine	132-135	glutathione synthetase	Homo sapiens	99-121
15141215-0	2004	The GTPase-activating protein Rap1GAP uses a catalytic asparagine.	Asparagine	55-65	RAP1 GTPase activating protein	Homo sapiens	30-37
15007078-1	2004	A serine (Ser-700) amino acid rather than an asparagine (Asn-700) at residue 700 of thrombospondin-1 has been linked to an increased risk for development of premature, familial heart attacks.	Asparagine	57-60	thrombospondin 1	Homo sapiens	84-100
15007078-2	2004	We now have identified both functional and structural differences between the Ser-700 and Asn-700 thrombospondin-1 variants.	Asparagine	90-93	thrombospondin 1	Homo sapiens	98-114
15111055-8	2004	Together with previous crystal structure data, the new functional data provide a mechanistic understanding of the conserved histidine, lysine and asparagine residues found among all PLD family members.	Asparagine	146-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	182-185
15141215-9	2004	By mutational analysis, fluorescence titration and stopped-flow kinetic assay, we demonstrate that Rap1GAP provides a catalytic asparagine to stimulate GTP hydrolysis.	Asparagine	128-138	RAP1 GTPase activating protein	Homo sapiens	99-106
15195977-1	2004	L-Asparaginase was chemically modified with 2,4-bis(O-methoxypolyethyleneglycol)-6-chloro-S-triazine (mPEG2) in the presence of L-asparagine.	Asparagine	128-140	insulin-like growth factor 2	Mus musculus	102-107
15100291-1	2004	The asparagine-specific endoprotease (AEP) controls lysosomal processing of the potential autoantigen myelin basic protein (MBP) by human B lymphoblastoid cells, a feature implicated in the immunopathogenesis of multiple sclerosis.	Asparagine	4-14	myelin basic protein	Homo sapiens	102-122
15115518-4	2004	The mutation is predicted to result in an asparagine to histidine substitution (N160H) at the beginning of the alpha-helical 1A domain of keratin 9.	Asparagine	42-52	keratin 9	Homo sapiens	138-147
15100291-1	2004	The asparagine-specific endoprotease (AEP) controls lysosomal processing of the potential autoantigen myelin basic protein (MBP) by human B lymphoblastoid cells, a feature implicated in the immunopathogenesis of multiple sclerosis.	Asparagine	4-14	myelin basic protein	Homo sapiens	124-127
15105550-4	2004	Arginine-to-asparagine substitutions in this region decreased the level of the ORF3 protein accumulation in nuclei.	Asparagine	12-22	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	79-83
15029250-7	2004	The structures reveal the basis for preferential recognition of specific LAT sites by Gads, as well as for the relatively greater promiscuity of the related adaptor Grb2, whose binding also requires asparagine at position +2 C-terminal to the phosphorylated tyrosine.	Asparagine	199-209	growth factor receptor bound protein 2	Homo sapiens	165-169
14766940-3	2004	Two important charge differences in beta-TM compared to alpha-TM are the exchange of serine and histidine at positions 229 and 276 with glutamic acid and asparagine, respectively, imparting a more negative charge to beta-TM relative to alpha-TM.	Asparagine	154-164	tropomyosin 1, alpha	Mus musculus	56-64
14766940-3	2004	Two important charge differences in beta-TM compared to alpha-TM are the exchange of serine and histidine at positions 229 and 276 with glutamic acid and asparagine, respectively, imparting a more negative charge to beta-TM relative to alpha-TM.	Asparagine	154-164	tropomyosin 1, alpha	Mus musculus	236-244
14749323-4	2004	274, 1519-1524) that tunicamycin, an inhibitor of asparagine-linked glycosylation, significantly inhibited organic anion transport in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an important role of glycosylation in mOAT1 function.	Asparagine	50-60	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	192-197
14749323-9	2004	In contrast, a simultaneous replacement of all asparagines in both mOAT1 and hOAT1 impaired the trafficking of the transporters to the plasma membrane.	Asparagine	47-58	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	67-72
14749323-9	2004	In contrast, a simultaneous replacement of all asparagines in both mOAT1 and hOAT1 impaired the trafficking of the transporters to the plasma membrane.	Asparagine	47-58	solute carrier family 22 member 6	Homo sapiens	77-82
14736728-0	2004	Mutation of the glycosylated asparagine residue 286 in human CLN2 protein results in loss of enzymatic activity.	Asparagine	29-39	tripeptidyl peptidase 1	Homo sapiens	61-65
14734545-5	2004	Individual alanine mutations of seven conserved amino acids flanking the hydroxylated asparagine in HIF-1alpha revealed the importance of the valine (Val-802) adjacent to the targeted asparagine.	Asparagine	86-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
14734545-5	2004	Individual alanine mutations of seven conserved amino acids flanking the hydroxylated asparagine in HIF-1alpha revealed the importance of the valine (Val-802) adjacent to the targeted asparagine.	Asparagine	184-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
14734545-8	2004	Molecular modeling of the HIF-1alpha CAD V802A in complex with FIH-1 predicted an alteration in asparagine positioning compared with the wild type HIF-1alpha CAD, providing an explanation for the impaired catalysis observed and confirming the importance of Val-802 in asparaginyl hydroxylation by FIH-1.	Asparagine	96-106	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	63-68
14734545-8	2004	Molecular modeling of the HIF-1alpha CAD V802A in complex with FIH-1 predicted an alteration in asparagine positioning compared with the wild type HIF-1alpha CAD, providing an explanation for the impaired catalysis observed and confirming the importance of Val-802 in asparaginyl hydroxylation by FIH-1.	Asparagine	96-106	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	297-302
15030991-9	2004	Interestingly this is the third mutation to affect asparagine 144, reinforcing the important role for this amino acid in the function of ferroportin1.	Asparagine	51-61	solute carrier family 40 member 1	Homo sapiens	137-149
14702339-3	2004	Human TPP I has five potential N-glycosylation sites at Asn residues 210, 222, 286, 313, and 443.	Asparagine	56-59	tripeptidyl peptidase 1	Homo sapiens	6-11
15034020-7	2004	The predicted surface on a three-dimensional homology model of the tyrosine phosphatase domain of IA-2 was analyzed for clusters of Asn, Glu, and aromatic residues and amino acids contributing to the epitope investigated using site-directed mutagenesis.	Asparagine	132-135	protein tyrosine phosphatase receptor type N	Homo sapiens	98-102
14702339-11	2004	Phospholabeling experiments revealed that N-glycans at Asn-210 and Asn-286 of TPP I preferentially accept a phosphomannose marker.	Asparagine	55-58	tripeptidyl peptidase 1	Homo sapiens	78-83
14702339-11	2004	Phospholabeling experiments revealed that N-glycans at Asn-210 and Asn-286 of TPP I preferentially accept a phosphomannose marker.	Asparagine	67-70	tripeptidyl peptidase 1	Homo sapiens	78-83
14702339-12	2004	Thus, a dual role of oligosaccharide at Asn-286 in folding and lysosomal targeting could contribute to the unusual, but cell type-dependent, fate of misfolded TPP I conformer and represent the molecular basis of the disease process in subjects with naturally occurring missense mutation at Asn-286.	Asparagine	40-43	tripeptidyl peptidase 1	Homo sapiens	159-164
14702339-12	2004	Thus, a dual role of oligosaccharide at Asn-286 in folding and lysosomal targeting could contribute to the unusual, but cell type-dependent, fate of misfolded TPP I conformer and represent the molecular basis of the disease process in subjects with naturally occurring missense mutation at Asn-286.	Asparagine	290-293	tripeptidyl peptidase 1	Homo sapiens	159-164
14634792-1	2004	PURPOSE: To determine the minimum levels of L-asparaginase (ASNase) activity necessary to maintain L-asparagine (Asn) depletion under ASNase treatment in acute lymphoblastic leukemia (ALL).	Asparagine	99-111	asparaginase and isoaspartyl peptidase 1	Homo sapiens	44-58
14679202-3	2004	Unlike in contraceptive activity, where the glycans on the molecule have been shown to play a crucial role, mutagenesis of the asparagines at sites of N-linked glycosylation (Asn(28) and Asn(63)) to glutamine shows that the apoptogenic activity of glycodelin A is executed by the protein backbone.	Asparagine	127-138	progestagen associated endometrial protein	Homo sapiens	248-260
14764598-10	2004	In the MUC16 SEA domains, the conserved surface residues, Asn-10, Thr-12, Arg-63, Asp-75, Asp-112, Ser-115, and Phe-117, are clustered on the beta sheet surface, which may be functionally important.	Asparagine	58-61	mucin 16	Mus musculus	7-12
14670966-6	2004	Mutational analysis of the five divergent amino acids in EL2 between the two receptors revealed that three amino acids, Asn-177, Ile-183, and Leu-190, contribute to the capacity of EL2 to impart ATP agonism.	Asparagine	120-123	spectrin alpha, erythrocytic 1	Homo sapiens	57-60
14670966-6	2004	Mutational analysis of the five divergent amino acids in EL2 between the two receptors revealed that three amino acids, Asn-177, Ile-183, and Leu-190, contribute to the capacity of EL2 to impart ATP agonism.	Asparagine	120-123	spectrin alpha, erythrocytic 1	Homo sapiens	181-184
14634792-1	2004	PURPOSE: To determine the minimum levels of L-asparaginase (ASNase) activity necessary to maintain L-asparagine (Asn) depletion under ASNase treatment in acute lymphoblastic leukemia (ALL).	Asparagine	99-111	asparaginase and isoaspartyl peptidase 1	Homo sapiens	60-66
14634792-1	2004	PURPOSE: To determine the minimum levels of L-asparaginase (ASNase) activity necessary to maintain L-asparagine (Asn) depletion under ASNase treatment in acute lymphoblastic leukemia (ALL).	Asparagine	113-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	44-58
14634792-1	2004	PURPOSE: To determine the minimum levels of L-asparaginase (ASNase) activity necessary to maintain L-asparagine (Asn) depletion under ASNase treatment in acute lymphoblastic leukemia (ALL).	Asparagine	113-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	60-66
14634792-3	2004	RESULTS: In all but one patient showing high ASNase antibody titers, minimum ASNase activity to maintain Asn depletion levels below the limit of detection (40 ng/ml) ranged from 6 to 180 U/l with a median value of 16 U/l.	Asparagine	105-108	asparaginase and isoaspartyl peptidase 1	Homo sapiens	77-83
14634792-6	2004	Statistical analysis showed that ASNase activity in the range of 2-32 U/l was inversely correlated with Asn levels ( r=-0.803, P=0.001).	Asparagine	104-107	asparaginase and isoaspartyl peptidase 1	Homo sapiens	33-39
14634792-7	2004	CONCLUSION: These results show that Asn levels are strongly correlated with plasma ASNase activity even at low enzyme activities (&lt;50 U/l) and that this sensitive ASNase assay can be used to estimate plasma Asn depletion levels.	Asparagine	36-39	asparaginase and isoaspartyl peptidase 1	Homo sapiens	83-89
14634792-7	2004	CONCLUSION: These results show that Asn levels are strongly correlated with plasma ASNase activity even at low enzyme activities (&lt;50 U/l) and that this sensitive ASNase assay can be used to estimate plasma Asn depletion levels.	Asparagine	36-39	asparaginase and isoaspartyl peptidase 1	Homo sapiens	166-172
14634792-7	2004	CONCLUSION: These results show that Asn levels are strongly correlated with plasma ASNase activity even at low enzyme activities (&lt;50 U/l) and that this sensitive ASNase assay can be used to estimate plasma Asn depletion levels.	Asparagine	210-213	asparaginase and isoaspartyl peptidase 1	Homo sapiens	166-172
14971902-3	2004	The incorporation of these residues in the mAZ-pTyr-Xaa-Asn-NH2 series provided compounds with very high affinity for the Grb2 SH2 domain, in the 10(-8)-10(-9) range of Kd values.	Asparagine	56-59	MYC-associated zinc finger protein (purine-binding transcription factor)	Mus musculus	43-46
14971902-5	2004	Our results highlight the importance of the doubly negative charge borne by the pY + 1 amino acid in accordance with the interactions observed in the complex crystallized between mAZ-pTyr-(alphaMe)pTyr-Asn-NH2 and the Grb2 SH2 domain.	Asparagine	202-205	growth factor receptor bound protein 2	Homo sapiens	218-222
14989719-3	2004	B*0732 differs from HLA-B*0708 by one nucleotidic change at position 412 (from G to A) in exon 3, leading to an amino acidic substitution from Asp (GAC) to Asn (AAC) at codon 114.	Asparagine	156-159	major histocompatibility complex, class I, B	Homo sapiens	20-25
14989719-3	2004	B*0732 differs from HLA-B*0708 by one nucleotidic change at position 412 (from G to A) in exon 3, leading to an amino acidic substitution from Asp (GAC) to Asn (AAC) at codon 114.	Asparagine	156-159	glycine-N-acyltransferase	Homo sapiens	161-164
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Asparagine	164-167	TATA-box binding protein like 1	Homo sapiens	116-119
14971902-3	2004	The incorporation of these residues in the mAZ-pTyr-Xaa-Asn-NH2 series provided compounds with very high affinity for the Grb2 SH2 domain, in the 10(-8)-10(-9) range of Kd values.	Asparagine	56-59	growth factor receptor bound protein 2	Homo sapiens	122-126
14971902-5	2004	Our results highlight the importance of the doubly negative charge borne by the pY + 1 amino acid in accordance with the interactions observed in the complex crystallized between mAZ-pTyr-(alphaMe)pTyr-Asn-NH2 and the Grb2 SH2 domain.	Asparagine	202-205	MYC-associated zinc finger protein (purine-binding transcription factor)	Mus musculus	179-182
14770226-3	2004	Binding studies revealed that the synthetic oligosaccharide cluster is 46-fold more effective than the subunit Man(9)GlcNAc(2)Asn in inhibiting 2G12-binding to immobilized gp120.	Asparagine	126-129	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	172-177
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Asparagine	190-193	signal transducer and activator of transcription 1	Homo sapiens	125-130
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Asparagine	190-193	signal transducer and activator of transcription 1	Homo sapiens	132-138
14625295-8	2004	The side chain structures of Asn-382 and Thr-383 in PGHS-2 thus selectively influence two important aspects of cyclooxygenase catalytic regulation: activation by peroxide and self-inactivation.	Asparagine	29-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-58
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Asparagine	190-193	signal transducer and activator of transcription 1	Homo sapiens	125-130
14994986-8	2004	In particular, there is only a single amino acid difference between the PDFs of Musca and Drosophila; at position 14 Ser for Musca PDF and Asn for Drosophila PDF.	Asparagine	139-142	Pigment-dispersing factor	Drosophila melanogaster	72-75
14576770-4	2004	Caspase family of proteases has unique strong preference for cleavage of the target proteins next to asparagine residue.	Asparagine	101-111	caspase 6	Homo sapiens	0-7
14602718-6	2004	Further, functional characterization of an erythropoietin receptor mutant with asparagine at position 241 in a hematopoietic cell line showed that this protein could still be activated by erythropoietin yet was not constitutively active.	Asparagine	79-89	erythropoietin	Homo sapiens	43-57
14711516-6	2004	Recombinant Thy-1 from Lec1 cells contained (GlcNAc)(2)(Man)(5) on asparagine 60, whereas the oligosaccharides on asparagine 23 and 100 contained approximately 80% (GlcNAc)(2)(Man)(4) and approximately 20% (GlcNAc)(2)(Man)(5).	Asparagine	67-77	Thy-1 cell surface antigen	Homo sapiens	12-17
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Asparagine	109-112	trio Rho guanine nucleotide exchange factor	Homo sapiens	118-122
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Asparagine	109-112	Rac family small GTPase 1	Homo sapiens	130-134
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Asparagine	109-112	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	142-145
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Asparagine	109-112	Rac family small GTPase 1	Homo sapiens	222-226
14602718-6	2004	Further, functional characterization of an erythropoietin receptor mutant with asparagine at position 241 in a hematopoietic cell line showed that this protein could still be activated by erythropoietin yet was not constitutively active.	Asparagine	79-89	erythropoietin	Homo sapiens	188-202
14730973-8	2004	Specifically, substitutions Gln(6)--&gt;Glu(6) and Asn(10)--&gt;Lys(10) were introduced into the most potent [Ala(1,3,12),Gln(10),Har(11),Trp(14)]PTH(1-14)NH2 agonist.	Asparagine	51-54	parathyroid hormone	Homo sapiens	146-149
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Asparagine	94-104	melanocortin 4 receptor	Sus scrofa	114-118
14573609-4	2004	Heparanase protein was glycosylated at six Asn residues in human tumor cell lines.	Asparagine	43-46	heparanase	Homo sapiens	0-10
14707083-7	2004	The Thre(49)Ile polymorphism in the extracellular domain of BALB/c IL-4Ralpha has been demonstrated to disrupt N-linked glycosylation of Asn(47) and increase the dissociation rate of the IL-4Ralpha/IL-4 interaction.	Asparagine	137-140	interleukin 4 receptor, alpha	Mus musculus	67-77
14707083-7	2004	The Thre(49)Ile polymorphism in the extracellular domain of BALB/c IL-4Ralpha has been demonstrated to disrupt N-linked glycosylation of Asn(47) and increase the dissociation rate of the IL-4Ralpha/IL-4 interaction.	Asparagine	137-140	interleukin 4 receptor, alpha	Mus musculus	187-202
14744756-1	2004	Hydroxylation at an asparagine residue at the COOH-terminal activation domain of hypoxia-inducible factor (HIF)-1/2 alphas is essential for its inactivation under normoxic condition.	Asparagine	20-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-113
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Asparagine	94-104	melanocortin 4 receptor	Sus scrofa	151-155
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Asparagine	63-66	melanocortin 4 receptor	Sus scrofa	114-118
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Asparagine	63-66	melanocortin 4 receptor	Sus scrofa	151-155
15750791-3	2004	Our recent novel studies established that Edg-1/S1P1 is glycosylated in its N-terminal extracellular portion and further identified the specific glycosylation site as asparagine 30.	Asparagine	167-177	sphingosine-1-phosphate receptor 1	Homo sapiens	42-47
14744728-8	2004	In summary, our results suggest that the XPD codon 312 Asn allele may exert a modest positive effect on prostate cancer risk when two copies of the allele are present, and this effect is enhanced by the XRCC codon 399 Gln allele in its recessive state.	Asparagine	55-58	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	41-44
15750791-3	2004	Our recent novel studies established that Edg-1/S1P1 is glycosylated in its N-terminal extracellular portion and further identified the specific glycosylation site as asparagine 30.	Asparagine	167-177	sphingosine-1-phosphate receptor 1	Homo sapiens	48-52
14691230-3	2004	Crystallographic studies on DPPIV reveal clear N-linked glycosylation of nine Asn residues in DPPIV.	Asparagine	78-81	dipeptidyl peptidase 4	Homo sapiens	28-33
15013639-7	2004	The PTH/PTHrP receptor antagonist [Asn(10), Leu(11)]-PTHrP(7-34) acting through a receptor other than the PTH/PTHrP receptor increased SHR fetal and placental weights above vehicle (P&lt;0.05) to that of the WKY and restored SHR amniotic fluid volume (P&lt;0.05).	Asparagine	35-38	parathyroid hormone-like hormone	Rattus norvegicus	8-13
15013639-7	2004	The PTH/PTHrP receptor antagonist [Asn(10), Leu(11)]-PTHrP(7-34) acting through a receptor other than the PTH/PTHrP receptor increased SHR fetal and placental weights above vehicle (P&lt;0.05) to that of the WKY and restored SHR amniotic fluid volume (P&lt;0.05).	Asparagine	35-38	parathyroid hormone-like hormone	Rattus norvegicus	53-58
15013639-7	2004	The PTH/PTHrP receptor antagonist [Asn(10), Leu(11)]-PTHrP(7-34) acting through a receptor other than the PTH/PTHrP receptor increased SHR fetal and placental weights above vehicle (P&lt;0.05) to that of the WKY and restored SHR amniotic fluid volume (P&lt;0.05).	Asparagine	35-38	parathyroid hormone-like hormone	Rattus norvegicus	53-58
14671018-3	2004	Moreover, changes in total free Asn levels parallel the expression of ASN1, but not ASN2.	Asparagine	32-35	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	70-74
14691230-3	2004	Crystallographic studies on DPPIV reveal clear N-linked glycosylation of nine Asn residues in DPPIV.	Asparagine	78-81	dipeptidyl peptidase 4	Homo sapiens	94-99
14643929-6	2003	Residues Phe 174, Asn 182, Ser 191, Leu 196, Pro 199, Asn 266, Tyr 269, Asp 271 and Gln 275 appear to be additionally important elements of the active site but their conversion into corresponding Erg3p residues did not lead to a gain in desaturase activity.	Asparagine	18-21	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	196-201
14676317-1	2003	Recent evidence indicates that Stt3p plays a central role in the recognition and/or catalytic step in N-glycosylation (asparagine-linked glycosylation) in the lumen of the endoplasmic reticulum.	Asparagine	119-129	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	31-36
12890666-4	2003	Another member of this family of ATP/Mg2+-dependent enzymes, asparagine synthetase (AS-B), catalyzes intermolecular, rather than intramolecular, amide bond formation in asparagine biosynthesis.	Asparagine	61-71	arylsulfatase B	Homo sapiens	84-88
12970363-6	2003	Two NX(S/T) motifs in TRPC6 were mutated (Asn to Gln) by in vitro mutagenesis to delete one or both extracellular N-linked glycosylation sites.	Asparagine	42-45	transient receptor potential cation channel subfamily C member 6	Homo sapiens	22-27
14625171-4	2003	RESULTS: Sequence analysis confirmed the presence of the desired mutation site, and a mutation from K (Lys) to N (Asn) in codon 317 was identified in the SCN5A gene, indicating the successful induction of the mutation at K317N of the SCN5A gene.	Asparagine	114-117	sodium voltage-gated channel alpha subunit 5	Homo sapiens	154-159
14625171-4	2003	RESULTS: Sequence analysis confirmed the presence of the desired mutation site, and a mutation from K (Lys) to N (Asn) in codon 317 was identified in the SCN5A gene, indicating the successful induction of the mutation at K317N of the SCN5A gene.	Asparagine	114-117	sodium voltage-gated channel alpha subunit 5	Homo sapiens	234-239
14645481-4	2003	This residue (UV: lysine vs blue:asparagine or glutamate) corresponds to amino acid position glycine 90 (G90) in bovine rhodopsin, a site affected in autosomal dominant human congenital night blindness.	Asparagine	33-43	rhodopsin	Bos taurus	120-129
14632661-4	2003	The NA1 allele of CD16B has four asparagine (N)-linked glycosylation sites.	Asparagine	33-43	Fc gamma receptor IIIb	Homo sapiens	18-23
14583471-0	2003	Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.	Asparagine	142-145	matrix metallopeptidase 25	Homo sapiens	55-65
14583471-0	2003	Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.	Asparagine	142-145	matrix metallopeptidase 25	Homo sapiens	66-106
14583471-0	2003	Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.	Asparagine	142-145	matrix metallopeptidase 25	Homo sapiens	107-134
14583471-6	2003	Using the catalytically inactive mutant MMP-2EA (the E404A mutant of proMMP-2), which cannot autocatalytically mature from the intermediate form into the mature one, we show that MT6-MMP cleaves not only the known MT-MMP-processing site at Asn(66)-Leu but also the previously unsuspected Asn(109)-Tyr to yield a fully mature molecule.	Asparagine	240-243	matrix metallopeptidase 25	Homo sapiens	179-186
14583471-6	2003	Using the catalytically inactive mutant MMP-2EA (the E404A mutant of proMMP-2), which cannot autocatalytically mature from the intermediate form into the mature one, we show that MT6-MMP cleaves not only the known MT-MMP-processing site at Asn(66)-Leu but also the previously unsuspected Asn(109)-Tyr to yield a fully mature molecule.	Asparagine	288-291	matrix metallopeptidase 25	Homo sapiens	179-186
12890670-7	2003	We found that a mutant (DGK zeta S/D) in which serines within the MARCKS PSD were altered to aspartates (to mimic phosphorylation) had lower activity compared with wild-type DGK zeta or a control mutant (DGK zeta S/N) in which the same serines were changed to asparagines.	Asparagine	260-271	diacylglycerol kinase beta	Homo sapiens	24-27
12855677-6	2003	We produced RDH-S Delta 3 by mutating RDH-S to remove an "additional" Asn residue relative to RDH1 in its center, to convert three residues into RDH1 residues (L121P, S122N, and Q123E), and to substitute RDH1 sequence G208FKTCVTSSD for RDH-S sequence F208-FLTGMASSA.	Asparagine	70-73	4short chain dehydrogenase/reductase family 9C, member 7	Mus musculus	12-17
12890670-7	2003	We found that a mutant (DGK zeta S/D) in which serines within the MARCKS PSD were altered to aspartates (to mimic phosphorylation) had lower activity compared with wild-type DGK zeta or a control mutant (DGK zeta S/N) in which the same serines were changed to asparagines.	Asparagine	260-271	diacylglycerol kinase zeta	Homo sapiens	24-32
12855677-6	2003	We produced RDH-S Delta 3 by mutating RDH-S to remove an "additional" Asn residue relative to RDH1 in its center, to convert three residues into RDH1 residues (L121P, S122N, and Q123E), and to substitute RDH1 sequence G208FKTCVTSSD for RDH-S sequence F208-FLTGMASSA.	Asparagine	70-73	4short chain dehydrogenase/reductase family 9C, member 7	Mus musculus	38-43
12855677-6	2003	We produced RDH-S Delta 3 by mutating RDH-S to remove an "additional" Asn residue relative to RDH1 in its center, to convert three residues into RDH1 residues (L121P, S122N, and Q123E), and to substitute RDH1 sequence G208FKTCVTSSD for RDH-S sequence F208-FLTGMASSA.	Asparagine	70-73	4short chain dehydrogenase/reductase family 9C, member 7	Mus musculus	38-43
12860980-1	2003	Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently discovered lysosomal cysteine protease that specifically cleaves after asparagine residues.	Asparagine	139-149	legumain	Homo sapiens	10-35
14557182-0	2003	A peculiar autosomal dominant macular dystrophy caused by an asparagine deletion at codon 169 in the peripherin/RDS gene.	Asparagine	61-71	peripherin	Homo sapiens	101-111
14557182-0	2003	A peculiar autosomal dominant macular dystrophy caused by an asparagine deletion at codon 169 in the peripherin/RDS gene.	Asparagine	61-71	peripherin 2	Homo sapiens	112-115
14557182-8	2003	This mutation resulted in an asparagine (Asn) deletion in the peripherin/RDS protein and was not found in 155 control individuals.	Asparagine	29-39	peripherin	Homo sapiens	62-72
14557182-8	2003	This mutation resulted in an asparagine (Asn) deletion in the peripherin/RDS protein and was not found in 155 control individuals.	Asparagine	29-39	peripherin 2	Homo sapiens	73-76
14557182-8	2003	This mutation resulted in an asparagine (Asn) deletion in the peripherin/RDS protein and was not found in 155 control individuals.	Asparagine	41-44	peripherin	Homo sapiens	62-72
14557182-8	2003	This mutation resulted in an asparagine (Asn) deletion in the peripherin/RDS protein and was not found in 155 control individuals.	Asparagine	41-44	peripherin 2	Homo sapiens	73-76
12844488-6	2003	Patients with the XPD codon 312 Asn allele were less likely to have p53 mutations (13.8%) than XPD 312 Asp/Asp (27.3%) [odds ratio (OR) 0.43, 95% confidence interval (CI) 0.20-0.89, P = 0.023].	Asparagine	32-35	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	18-21
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Asparagine	140-143	solute carrier family 2 member 1	Homo sapiens	38-43
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Asparagine	140-143	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	83-86
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Asparagine	173-176	solute carrier family 2 member 1	Homo sapiens	38-43
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Asparagine	173-176	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	83-86
12844488-6	2003	Patients with the XPD codon 312 Asn allele were less likely to have p53 mutations (13.8%) than XPD 312 Asp/Asp (27.3%) [odds ratio (OR) 0.43, 95% confidence interval (CI) 0.20-0.89, P = 0.023].	Asparagine	32-35	tumor protein p53	Homo sapiens	68-71
14517261-4	2003	Here we show that a strictly conserved E2 asparagine residue is critical for catalysis of E2- and E2/RING E3-dependent isopeptide bond formation, but dispensable for upstream and downstream reactions of Ub thiol ester formation.	Asparagine	42-52	cystatin 12, pseudogene	Homo sapiens	90-108
12972262-3	2003	More specifically, the environment around the Asp21-Lys29 ion pair has been altered through mutations at position 25, which is an asparagine in mammalian ubiquitin and a positively-charged residue in many other ubiquitin-like proteins.	Asparagine	130-140	beta-secretase 2	Homo sapiens	46-51
12956876-5	2003	The strict conservation of critical amino-acid residues like cystein and asparagine residues in Woodchuck CD28 and CTLA-4 suggests that both molecules may structurally resemble their human or mouse homologues.	Asparagine	73-83	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	115-121
13679430-2	2003	The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for beta2 and beta3 subunit-containing receptors determined by a single asparagine residue.	Asparagine	174-184	hemoglobin, beta adult minor chain	Mus musculus	106-111
12773476-2	2003	We have previously shown that in living cells N-glycosylation of the prion protein (PrP) is also abolished when its Asn-Ile-Thr and Asn-Phe-Thr sequons are less than 60 residues from the C-terminus (Walmsley and Hooper [2003] Biochemical Journal, 370, 351-355).	Asparagine	116-119	prion protein	Homo sapiens	84-87
12962490-1	2003	A double mutant cycle has been used to evaluate interaction energies between the global stabilizer mutation asparagine 52 --&gt; isoleucine (N52I) in iso-1-cytochrome c and mutations producing single surface histidines at positions 26, 33, 39, 54, 73, 89, and 100.	Asparagine	108-118	eukaryotic translation initiation factor 1	Homo sapiens	150-155
12962490-1	2003	A double mutant cycle has been used to evaluate interaction energies between the global stabilizer mutation asparagine 52 --&gt; isoleucine (N52I) in iso-1-cytochrome c and mutations producing single surface histidines at positions 26, 33, 39, 54, 73, 89, and 100.	Asparagine	108-118	cytochrome c, somatic	Homo sapiens	156-168
12954382-1	2003	In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG(2)) by using ligand-immobilized affinity column systems L-asparagine-Sepharose CL-4B and Procion red-Sepharose CL-4B, respectively.	Asparagine	223-235	catalase	Mus musculus	69-77
12954382-1	2003	In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG(2)) by using ligand-immobilized affinity column systems L-asparagine-Sepharose CL-4B and Procion red-Sepharose CL-4B, respectively.	Asparagine	223-235	insulin-like growth factor 2	Mus musculus	163-169
14628939-3	2003	Two mutations (DHFR Asn-108 and Ile-51) were too common to be useful predictors.	Asparagine	20-23	dihydrofolate reductase	Homo sapiens	15-19
12939660-5	2003	The single base mutation located in the linker region of the SMAD3 protein was A --> T change in the position 2 of codon 197 and resulted in an asparagine to isoleucine amino-acid substitution.	Asparagine	144-154	SMAD family member 3	Homo sapiens	61-66
14614991-1	2003	The Disproportionate micromelia (Dmm) mouse has a three nucleotide deletion in Col2a1 in the region encoding the C-propeptide which results in the substitution of one amino acid, Asn, for two amino acids, Lys-Thr.	Asparagine	179-182	collagen, type II, alpha 1	Mus musculus	79-85
12871647-8	2003	The mutation of Asn 289 in the channel domain of beta(2) to a serine (the homologous residue in beta(1)) did not significantly depress the effects of etifoxine at alpha(1)beta(2) receptors.	Asparagine	16-19	hemoglobin, beta adult minor chain	Mus musculus	49-55
12874385-4	2003	Functional analysis and complementation of an Escherichia coli asparagine auxotrophic strain show that AsnRS2 constitutes the archaeal homologue of the bacterial ammonia-dependent asparagine synthetase A (AS-A), therefore named archaeal asparagine synthetase A (AS-AR).	Asparagine	63-73	asparagine synthetase A	Escherichia coli	180-203
12775715-1	2003	Asparaginyl endopeptidase (AEP)/legumain, an asparagine-specific cysteine proteinase in animals, is an ortholog of plant vacuolar processing enzyme (VPE), which processes the exposed asparagine residues of various vacuolar proteins.	Asparagine	45-55	legumain	Mus musculus	0-25
12794066-6	2003	Surface residues of thrombin further involved in high specificity fibrin-enhanced factor XIII activation were identified as His-66, Tyr-71, and Asn-74.	Asparagine	144-147	coagulation factor II, thrombin	Homo sapiens	20-28
12815060-2	2003	Bves contains two asparagine-linked glycosylation sites within the amino terminus and three putative membrane domains.	Asparagine	18-28	blood vessel epicardial substance	Gallus gallus	0-4
12924948-11	2003	On the basis of the substrates analyzed, residues Ser(1229), Ser(1231), Gln(1235), and Asn(1241) play an important role in determining the specificity of MRP3, while mutation of Tyr(1232), Ser(1233), and Thr(1237) affects overall activity.	Asparagine	87-90	ATP binding cassette subfamily C member 3	Homo sapiens	154-158
12911295-1	2003	The objective of this study was to determine the effects of proline hydroxylation in the collagen-like domain and Asn(187)-linked glycosylation in the globular domain on the molecular and functional properties of human surfactant protein A1 (SP-A1).	Asparagine	114-117	surfactant protein A1	Homo sapiens	219-240
12851728-6	2003	We identified a previously unreported GGT right curved arrow GAT transition at codon 451 in exon 3, resulting in a glycine to asparagine substitution in one POAG patient.	Asparagine	126-136	glycine-N-acyltransferase	Homo sapiens	61-64
12888215-4	2003	Expression at approximately twice normal levels of a mutant MARCKS protein in which the four PKC phosphorylatable serines were replaced by asparagines did not allow postnatal survival of Marcks(-/-) pups.	Asparagine	139-150	myristoylated alanine rich protein kinase C substrate	Mus musculus	60-66
14640038-10	2003	In homozygous FAF(Asn-187) the 65-kDa fragment containing the amyloid forming region and the 55-kDa fragment, devoid of that region, was the major gelsolin species in the plasma.	Asparagine	18-21	ubiquitin specific peptidase 9 X-linked	Homo sapiens	14-17
14640038-10	2003	In homozygous FAF(Asn-187) the 65-kDa fragment containing the amyloid forming region and the 55-kDa fragment, devoid of that region, was the major gelsolin species in the plasma.	Asparagine	18-21	gelsolin	Homo sapiens	147-155
12874235-7	2003	The greater hemagglutination inhibitory activity of pSP-A is due to porcine-specific structural features of the conserved asparagine-linked oligosaccharide in the carbohydrate recognition domain of SP-A.	Asparagine	122-132	surfactant protein A1	Homo sapiens	52-57
12874235-7	2003	The greater hemagglutination inhibitory activity of pSP-A is due to porcine-specific structural features of the conserved asparagine-linked oligosaccharide in the carbohydrate recognition domain of SP-A.	Asparagine	122-132	surfactant protein A1	Homo sapiens	53-57
12857932-2	2003	Asparagine 232, valine 233, tyrosine 235, and glutamic acid 237 in the third extracellular domain (EL3) of the receptor are critical determinants of the host range difference between mice and humans.	Asparagine	0-10	epilepsy 3	Mus musculus	99-102
12857933-5	2003	Asparagine is prevalent in Tat proteins of viruses in clades A, C, and D, which are major etiologic agents of AIDS.	Asparagine	0-10	tyrosine aminotransferase	Homo sapiens	27-30
12857933-6	2003	We suggest that selection for asparagine in position 23 confers an advantage to the virus, since it can compensate for deleterious mutations in Tat.	Asparagine	30-40	tyrosine aminotransferase	Homo sapiens	144-147
12682056-5	2003	A mutagenesis study on the K+ binding side chains showed that Asn-13 and Asp-65 are essential for potassium binding, but the impact on the stability of ArsC was the most extreme when mutating Ser-36.	Asparagine	62-65	Arsenate reductase	Staphylococcus aureus	152-156
14628453-3	2003	METHODS: At first, N-glycans linked to asparagines in glycoprotein EPO were released by peptide N-glycosidase F. To map asialyated N-glycans, sialic acid in N-glycans were removed by incubating N-glycans with sialidase.	Asparagine	39-50	erythropoietin	Homo sapiens	67-70
12738779-5	2003	This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1.	Asparagine	259-262	matrix metallopeptidase 11	Homo sapiens	54-58
12738779-5	2003	This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1.	Asparagine	259-262	matrix metallopeptidase 11	Homo sapiens	54-57
12826274-5	2003	Competition of melatonin for 2-[125I]-iodomelatonin binding revealed that mutation of Asn 16 in TM4 or His 7 in TM5 of the hMT(2) melatonin receptor significantly decreased the binding affinity for melatonin when compared with wild-type.	Asparagine	86-89	tropomyosin 3	Homo sapiens	112-115
12746429-6	2003	In addition, we have generated a DNA nonbinding point mutant of Nkx3.2 (Nkx3.2-N200Q), which contains an asparagine to glutamine missense mutation in the homeodomain.	Asparagine	105-115	NK3 homeobox 2	Homo sapiens	64-70
12746429-6	2003	In addition, we have generated a DNA nonbinding point mutant of Nkx3.2 (Nkx3.2-N200Q), which contains an asparagine to glutamine missense mutation in the homeodomain.	Asparagine	105-115	NK3 homeobox 2	Homo sapiens	64-69
12832058-2	2003	We have now found that aspartate-to-asparagine substitutions at these positions differentially affect the binding of four different anti-CXCR4 monoclonal antibodies as well as the infectivity of diverse human immunodeficiency virus type 1 (HIV-1) strains and clinical isolates.	Asparagine	36-46	C-X-C motif chemokine receptor 4	Homo sapiens	137-142
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Asparagine	136-139	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12839621-2	2003	The N-terminal of Sup35, necessary for [PSI+], contains oligopeptide repeats and multiple Gln/Asn residues.	Asparagine	94-97	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	18-23
12839621-3	2003	RESULTS: We replaced the Gln/Asn-rich prion repeats of Sup35 with non-Gln/Asn repeats from heterologous yeast strains.	Asparagine	29-32	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	55-60
12839621-7	2003	CONCLUSIONS: These findings suggest the existence of an alternative, Hsp104-independent pathway to replicate non-Gln/Asn variant Sup35 prion seeds.	Asparagine	117-120	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	129-134
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Asparagine	136-139	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	48-53
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Asparagine	136-139	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Asparagine	136-139	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12810626-3	2003	In this study, we present evidence that human Bcl-xL is deamidated at asparagines 52 and 66 and that the rate of Bcl-xL deamidation is significantly lower in hepatocellular carcinomas than in normal or adjacent nontumor liver tissues.	Asparagine	70-81	BCL2 like 1	Homo sapiens	46-52
12840230-10	2003	The DING protein (N-terminal amino acid sequence Asp-Ile-Asn-Gly) that binds to genistein with high affinity is one of these.	Asparagine	57-60	ring finger protein 2	Homo sapiens	4-8
12697759-6	2003	Together these inactivating substitutions identified seven NR1 residues (Ile-385, Gln-387, Glu-388, Thr-500, Asn-502, Ala-696, and Val-717) that undergo proximity-induced covalent coupling with specific regions of the bound antagonist and disclose its mode of docking in the glycine binding pocket of the NMDA receptor.	Asparagine	109-112	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	59-62
12857817-10	2003	Specific amino acids within the AtCNGC2 pore selectivity filter (Asn-416, Asp-417) are demonstrated to facilitate K(+) over Na(+) conductance.	Asparagine	65-68	Cyclic nucleotide-regulated ion channel family protein	Arabidopsis thaliana	32-39
12753071-2	2003	The major pathophysiological significance of L-asparaginase activity is in its clinical use for the treatment of acute lymphatic leukaemia and neoplasias that require asparagine and obtain it from circulating pools.	Asparagine	167-177	asparaginase and isoaspartyl peptidase 1	Homo sapiens	45-59
12773146-8	2003	Secondly, hydroxylation of an asparagine residue in the C-terminal transactivation domain of HIFalpha directly prevents its interaction with the co-activator p300.	Asparagine	30-40	E1A binding protein p300	Homo sapiens	158-162
12778490-3	2003	We observed, for clone F1-9, that a substitution of aspartic acid for asparagine in the core region of the epitope increased the stimulatory capacity of the peptide about 100-fold in comparison with the natural peptide.	Asparagine	70-80	coagulation factor II, thrombin	Homo sapiens	23-27
12679340-5	2003	In OTCase, mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine and impaired the interaction with arginase.	Asparagine	70-73	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	3-9
12679340-5	2003	In OTCase, mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine and impaired the interaction with arginase.	Asparagine	79-82	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	3-9
12756162-9	2003	The data identify a specific region of the FcgammaRI TM and its asparagine as important for FcgammaRI cell surface expression in the absence of the gamma chain and for distinguishing the FcgammaRI and FcgammaRIIIA phenotypes.	Asparagine	64-74	Fc gamma receptor Ia	Homo sapiens	43-52
12756162-9	2003	The data identify a specific region of the FcgammaRI TM and its asparagine as important for FcgammaRI cell surface expression in the absence of the gamma chain and for distinguishing the FcgammaRI and FcgammaRIIIA phenotypes.	Asparagine	64-74	Fc gamma receptor Ia	Homo sapiens	92-101
12756162-9	2003	The data identify a specific region of the FcgammaRI TM and its asparagine as important for FcgammaRI cell surface expression in the absence of the gamma chain and for distinguishing the FcgammaRI and FcgammaRIIIA phenotypes.	Asparagine	64-74	Fc gamma receptor Ia	Homo sapiens	92-101
12756162-9	2003	The data identify a specific region of the FcgammaRI TM and its asparagine as important for FcgammaRI cell surface expression in the absence of the gamma chain and for distinguishing the FcgammaRI and FcgammaRIIIA phenotypes.	Asparagine	64-74	Fc gamma receptor IIIa	Homo sapiens	201-213
12824871-7	2003	Additionally, we also demonstrated coexpression of Gly-Asn-Asn-Lys510-513 (GNNK) + and GNNK - isoforms of the c-kit gene with dominance of the GNNK - transcript in all testicular GCTs.	Asparagine	55-58	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	110-115
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Asparagine	36-39	hematopoietic cell signal transducer	Homo sapiens	88-93
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Asparagine	36-39	vav guanine nucleotide exchange factor 1	Homo sapiens	186-190
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Asparagine	36-39	killer cell lectin like receptor K1	Homo sapiens	292-297
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Asparagine	36-39	hematopoietic cell signal transducer	Homo sapiens	298-303
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Asparagine	36-39	spleen associated tyrosine kinase	Homo sapiens	330-333
12805621-2	2003	Because Asn serves as an important nitrogen storage and transport compound used to allocate nitrogen resources between source and sink organs, we tested whether overexpression of the major expressed gene for Asn synthetase, ASN1, would lead to changes in nitrogen status in the ultimate storage organ for metabolites-seeds.	Asparagine	8-11	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	224-228
12805621-8	2003	This was at least partially due to an enhanced transport of Asn from source to sink via the phloem, as demonstrated by the increased levels of Asn in phloem exudates of the 35S-ASN1 plants.	Asparagine	60-63	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	177-181
12805621-7	2003	In 35S-ASN1 lines, sink tissues such as flowers and developing siliques exhibit a higher level of free Asn than source tissues such as leaves and stems, despite significantly higher levels of ASN1 mRNA observed in the source tissues.	Asparagine	103-106	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	7-11
12805621-8	2003	This was at least partially due to an enhanced transport of Asn from source to sink via the phloem, as demonstrated by the increased levels of Asn in phloem exudates of the 35S-ASN1 plants.	Asparagine	143-146	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	177-181
12637557-5	2003	Among them, mutations at Asn-948 or Tyr-951 conferred up to 8-fold higher colony formation frequency in a URA3 forward mutation assay, and 79-fold higher trp1 reversion frequency was observed for Y951P in yeast.	Asparagine	25-28	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	106-110
12637557-5	2003	Among them, mutations at Asn-948 or Tyr-951 conferred up to 8-fold higher colony formation frequency in a URA3 forward mutation assay, and 79-fold higher trp1 reversion frequency was observed for Y951P in yeast.	Asparagine	25-28	phosphoribosylanthranilate isomerase TRP1	Saccharomyces cerevisiae S288C	154-158
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	62-65	dihydrofolate reductase	Homo sapiens	276-280
12706347-0	2003	Asparagine 81, an invariant glycosylation site near apyrase conserved region 1, is essential for full enzymatic activity of ecto-nucleoside triphosphate diphosphohydrolase 3.	Asparagine	0-10	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	124-173
12706347-4	2003	Only one of these putative glycosylation sites, asparagine 81 in NTPDase3, which is located near apyrase conserved region 1 (ACR1), is invariant in all the cell surface membrane eNTPDases.	Asparagine	48-58	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	65-73
12833571-10	2003	Furthermore, the chemical modification demonstrated that exchanging aspartic-glutamic acids to asparagine-glutamine residues in TS1 increased the binding of TS1 to cytokeratin 8, indicating that there is at least one acidic amino acid that is an obstacle in the TS1-CK8 binding.	Asparagine	95-105	keratin 8	Homo sapiens	164-177
12692559-4	2003	Caspase-mediated cleavage of DIAP1 at position 20 converts the more stable pro-N-degron of DIAP1 into the highly unstable, Asn-bearing, DIAP1 N-degron of the N-end rule degradation pathway.	Asparagine	123-126	Death caspase-1	Drosophila melanogaster	0-7
12692559-4	2003	Caspase-mediated cleavage of DIAP1 at position 20 converts the more stable pro-N-degron of DIAP1 into the highly unstable, Asn-bearing, DIAP1 N-degron of the N-end rule degradation pathway.	Asparagine	123-126	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	29-34
12692559-5	2003	Thus, DIAP1 represents the first known metazoan substrate of the N-end rule pathway that is targeted for degradation through its amino-terminal Asn residue.	Asparagine	144-147	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	6-11
12695525-0	2003	Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.	Asparagine	35-45	cholecystokinin B receptor	Homo sapiens	57-83
12695525-0	2003	Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.	Asparagine	35-45	cholecystokinin	Homo sapiens	57-72
12785846-2	2003	The key building block, a pentasaccharide-Asn analogue containing two thiol residues, was incorporated into CD52 by 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.	Asparagine	42-45	CD52 molecule	Homo sapiens	108-112
12726995-5	2003	From our data, we conclude that N-glycosylation of either Asn(4) or Asn(16) is required and sufficient for expression of functionally active TPalpha on the PM while the fully non-glycosylated TPalpha(N4,N16-Q4,Q16) is almost completely retained within the endoplasmic reticulum (ER) and remains functionally inactive, failing to associate with its coupling G protein Galpha(q) and, in turn, failing to mediate phospholipase (PL) Cbeta activation.	Asparagine	58-61	plasminogen activator, tissue type	Homo sapiens	141-148
12726995-5	2003	From our data, we conclude that N-glycosylation of either Asn(4) or Asn(16) is required and sufficient for expression of functionally active TPalpha on the PM while the fully non-glycosylated TPalpha(N4,N16-Q4,Q16) is almost completely retained within the endoplasmic reticulum (ER) and remains functionally inactive, failing to associate with its coupling G protein Galpha(q) and, in turn, failing to mediate phospholipase (PL) Cbeta activation.	Asparagine	68-71	plasminogen activator, tissue type	Homo sapiens	141-148
12713872-1	2003	BACKGROUND: Aspartyl (asparaginyl) beta-hydroxylase (AAH) is an alpha-ketoglutarate-dependent dioxygenase that hydroxylates aspartate and asparagine residues in EGF-like domains of proteins.	Asparagine	138-148	aspartate beta-hydroxylase	Homo sapiens	12-51
12713872-1	2003	BACKGROUND: Aspartyl (asparaginyl) beta-hydroxylase (AAH) is an alpha-ketoglutarate-dependent dioxygenase that hydroxylates aspartate and asparagine residues in EGF-like domains of proteins.	Asparagine	138-148	aspartate beta-hydroxylase	Homo sapiens	53-56
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Asparagine	250-253	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Asparagine	250-253	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-124
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Asparagine	250-253	hypoxia inducible factor 1 subunit alpha	Homo sapiens	196-206
15969005-5	2003	The data of mutant clone DNA sequence showed that the amino acid of light chain gene of the parent anti-CD20 antibody (H47) was successful mutated as Ser (GAG)-Asn (CAG).	Asparagine	160-163	keratin 20	Homo sapiens	104-108
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	62-65	dihydrofolate reductase	Homo sapiens	361-365
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	176-179	dihydrofolate reductase	Homo sapiens	276-280
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	176-179	dihydrofolate reductase	Homo sapiens	361-365
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	176-179	dihydrofolate reductase	Homo sapiens	276-280
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Asparagine	176-179	dihydrofolate reductase	Homo sapiens	361-365
12578822-4	2003	A striking feature of the C/EBPalpha protein-DNA interface that distinguishes it from known bZIP-DNA complexes is the central role of Arg(289), which is hydrogen-bonded to base A(3), phosphate, Asn(292) (invariant in bZIPs), and Asn(293).	Asparagine	194-197	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	26-36
12578822-4	2003	A striking feature of the C/EBPalpha protein-DNA interface that distinguishes it from known bZIP-DNA complexes is the central role of Arg(289), which is hydrogen-bonded to base A(3), phosphate, Asn(292) (invariant in bZIPs), and Asn(293).	Asparagine	229-232	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	26-36
12578822-6	2003	In accordance with the structural model, mutation of Arg(289) or a pair of its interacting partners (Tyr(285) and Asn(293)) abolished C/EBPalpha binding activity.	Asparagine	114-117	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	134-144
12525479-3	2003	Substitution of several aspartate residues by asparagine completely abolished Ca(2+)-dependent membrane targeting of PKCalpha.	Asparagine	46-56	protein kinase C, alpha	Rattus norvegicus	117-125
12554741-2	2003	Recombinant human phenylalanine hydroxylase (hPAH) expressed in Escherichia coli for 24 h at 28 degrees C has been found by two-dimensional electrophoresis to exist as a mixture of four to five molecular forms as a result of nonenzymatic deamidation of labile Asn residues.	Asparagine	260-263	phenylalanine hydroxylase	Homo sapiens	18-43
12705852-4	2003	Here we show that this step can be performed in B lymphocytes by asparagine endopeptidase (AEP), which targets different asparagine residues in the lumenal domain of human and mouse invariant chain.	Asparagine	65-75	legumain	Homo sapiens	91-94
12812052-14	2003	The sequencing results showed that there was one single nucleotide mutation: A--&gt;G at cDNA 152 of GDF9 gene in sheep, and this mutation resulted in an amino acid change: asparagine--&gt;aspartic acid.	Asparagine	173-183	growth/differentiation factor 9	Ovis aries	101-105
12554741-2	2003	Recombinant human phenylalanine hydroxylase (hPAH) expressed in Escherichia coli for 24 h at 28 degrees C has been found by two-dimensional electrophoresis to exist as a mixture of four to five molecular forms as a result of nonenzymatic deamidation of labile Asn residues.	Asparagine	260-263	phenylalanine hydroxylase	Homo sapiens	45-49
12554741-11	2003	Moreover, deamidation of Asn(32) in the wt-hPAH (24 h expression at 28 degrees C) and the Asn(32) --&gt; Asp mutation both increase the initial rate of phosphorylation of Ser(16) by cAMP-dependent protein kinase (p &lt; 0.005).	Asparagine	25-28	phenylalanine hydroxylase	Homo sapiens	43-47
12676357-5	2003	The protein structure analysis of dMLK/slipper revealed, in addition to the conserved domains, a stretch of glutamine in the amino terminus and an asparagine-threonine stretch at the carboxy-terminus.	Asparagine	147-157	slipper	Drosophila melanogaster	34-38
12671081-4	2003	The dramatic increase in free Lys in the knockout mutant expressing the bacterial DHPS was associated with a significant reduction in the levels of Glu and Asp but also with an unexpected increase in the levels of Gln and Asn.	Asparagine	222-225	dihydrodipicolinate synthase 1	Arabidopsis thaliana	82-86
12787894-8	2003	Moreover, interactions of Asn-564 and Met-639 with the steroids were investigated by studying GR mutants of these amino acids.	Asparagine	26-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	94-96
12787894-9	2003	Met-639 participates in hydrophobic interactions mainly with GC side chains, while Asn-564 forms a hydrogen bond to the C11-OH group of the steroid.	Asparagine	83-86	RNA polymerase III subunit K	Homo sapiens	120-123
12643280-4	2003	The third epidermal growth factor-like repeat dramatically altered the Ca2+-dependent fluorescence transition for the Asn-700 constructs; the half-effective concentration (EC50) of Ca Asn-700 was 390 microM, and the EC50 of E3Ca Asn-700 was 70 microM.	Asparagine	118-121	epidermal growth factor	Homo sapiens	10-33
12522212-7	2003	Factor IXa variants with mutations in the region Phe(342)-Asn(346), located between the active site of factor IXa and factor VIII binding helix, showed reduced binding to both antibody CLB-FIX 13 and sLRP.	Asparagine	58-61	citramalyl-CoA lyase	Homo sapiens	185-188
12643280-4	2003	The third epidermal growth factor-like repeat dramatically altered the Ca2+-dependent fluorescence transition for the Asn-700 constructs; the half-effective concentration (EC50) of Ca Asn-700 was 390 microM, and the EC50 of E3Ca Asn-700 was 70 microM.	Asparagine	184-187	epidermal growth factor	Homo sapiens	10-33
12471026-8	2003	Comparison of their sequences reveals two variants at Na(v)1.4 positions 729 and 732: Ser and Asn in Na(v)1.4 compared with Thr and Lys in Na(v)1.1, respectively.	Asparagine	94-97	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	54-62
12471026-8	2003	Comparison of their sequences reveals two variants at Na(v)1.4 positions 729 and 732: Ser and Asn in Na(v)1.4 compared with Thr and Lys in Na(v)1.1, respectively.	Asparagine	94-97	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	101-109
16224397-5	2003	The first is a single nucleotide polymorphism at codon 188 of the ERCC1 gene that causes a C--&gt;T change but codes for the same amino acid, asparagine.	Asparagine	142-152	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	66-71
12600672-3	2003	In the present study, we examined the role of asparagine (N)-linked oligosaccharides in the proteolytic processing of proZPC and the subsequent secretion of ZPC by using site-directed mutagenesis of the consensus sequence for N-glycosylation, and tunicamycin, an inhibitor for N-glycosylation of glycoprotein.	Asparagine	46-56	zona pellucida sperm-binding protein 3	Coturnix japonica	121-124
12651125-2	2003	The predominant form of AT in plasma is ATalpha, which contains four glycosylated asparagine residues, and the minor form is ATbeta, which lacks the Asn-135 glycosylation.	Asparagine	82-92	serpin family C member 1	Homo sapiens	24-26
12592023-0	2003	Asparagine 285 plays a key role in transition state stabilization in rabbit muscle creatine kinase.	Asparagine	0-10	creatine kinase M-type	Oryctolagus cuniculus	76-98
12603326-0	2003	Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase.	Asparagine	22-32	phenylalanine hydroxylase	Homo sapiens	82-107
12603326-1	2003	Two dimensional electrophoresis has revealed a microheterogeneity in the recombinant human phenylalanine hydroxylase (hPAH) protomer, that is the result of spontaneous nonenzymatic deamidations of labile asparagine (Asn) residues [Solstad, T. and Flatmark, T. (2000) Eur.	Asparagine	204-214	phenylalanine hydroxylase	Homo sapiens	91-116
12603326-1	2003	Two dimensional electrophoresis has revealed a microheterogeneity in the recombinant human phenylalanine hydroxylase (hPAH) protomer, that is the result of spontaneous nonenzymatic deamidations of labile asparagine (Asn) residues [Solstad, T. and Flatmark, T. (2000) Eur.	Asparagine	216-219	phenylalanine hydroxylase	Homo sapiens	91-116
12493767-4	2003	Two mutations in the human TK2 gene, His-121 to Asn and Ile-212 to Asn, were recently described in patients with severe mtDNA depletion myopathy (Saada, A., Shaag, A., Mandel, H., Nevo, Y., Eriksson, S., and Elpeleg, O.	Asparagine	48-51	thymidine kinase 2	Homo sapiens	27-30
12482756-1	2003	The master switch of cellular hypoxia responses, hypoxia-inducible factor 1 (HIF-1), is hydroxylated by factor inhibiting HIF-1 (FIH-1) at a conserved asparagine residue under normoxia, which suppresses transcriptional activity of HIF-1 by abrogating its interaction with transcription coactivators.	Asparagine	151-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-75
12482756-1	2003	The master switch of cellular hypoxia responses, hypoxia-inducible factor 1 (HIF-1), is hydroxylated by factor inhibiting HIF-1 (FIH-1) at a conserved asparagine residue under normoxia, which suppresses transcriptional activity of HIF-1 by abrogating its interaction with transcription coactivators.	Asparagine	151-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-82
12482756-1	2003	The master switch of cellular hypoxia responses, hypoxia-inducible factor 1 (HIF-1), is hydroxylated by factor inhibiting HIF-1 (FIH-1) at a conserved asparagine residue under normoxia, which suppresses transcriptional activity of HIF-1 by abrogating its interaction with transcription coactivators.	Asparagine	151-161	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	104-127
12482756-1	2003	The master switch of cellular hypoxia responses, hypoxia-inducible factor 1 (HIF-1), is hydroxylated by factor inhibiting HIF-1 (FIH-1) at a conserved asparagine residue under normoxia, which suppresses transcriptional activity of HIF-1 by abrogating its interaction with transcription coactivators.	Asparagine	151-161	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	129-134
12482756-1	2003	The master switch of cellular hypoxia responses, hypoxia-inducible factor 1 (HIF-1), is hydroxylated by factor inhibiting HIF-1 (FIH-1) at a conserved asparagine residue under normoxia, which suppresses transcriptional activity of HIF-1 by abrogating its interaction with transcription coactivators.	Asparagine	151-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-127
12590570-0	2003	Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role.	Asparagine	150-160	adenylosuccinate lyase	Homo sapiens	47-69
12482845-8	2003	We propose that the electrostatic interactions in the first TPR motif made by Lys(8) or Asn(12) define part of the minimum interactions required for successful mSTI1-Hsc70 interaction.	Asparagine	88-91	stress-induced phosphoprotein 1	Mus musculus	160-165
12482845-8	2003	We propose that the electrostatic interactions in the first TPR motif made by Lys(8) or Asn(12) define part of the minimum interactions required for successful mSTI1-Hsc70 interaction.	Asparagine	88-91	heat shock protein family A (Hsp70) member 8	Homo sapiens	166-171
12590570-2	2003	Asn(276) of Bacillus subtilis adenylosuccinate lyase, a residue corresponding to the location of a human enzyme mutation, was replaced by Cys, Ser, Ala, Arg, and Glu.	Asparagine	0-3	adenylosuccinate lyase	Homo sapiens	30-52
12573244-2	2003	Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia.	Asparagine	96-99	fibrinogen beta chain	Homo sapiens	101-111
12557291-3	2003	This missense mutation causes an amino acid change from asparagine to glutamate (Asp27Glu) in the N-terminal region of the Cav-3 protein, which leads to a drastic decrease of Cav-3 protein expression in skeletal muscle tissue.	Asparagine	56-66	caveolin 3	Homo sapiens	123-128
12578369-3	2003	In this study, we have probed the role of this Asp in human 8-oxoguanine DNA glycosylase (hOgg1) by mutating it to Asn (D268N), Glu (D268E), and Gln (D268Q).	Asparagine	115-118	8-oxoguanine DNA glycosylase	Homo sapiens	90-95
12429731-2	2003	We have examined the consequences of mutating each of these sites (Asn --&gt; Gln or Thr --&gt; Ala) on post-translational processing of mSR-BI, cell surface expression, and HDL binding and lipid transport activities.	Asparagine	67-70	scavenger receptor class B, member 1	Mus musculus	137-143
12565836-4	2003	Site-directed mutagenesis of extracellular Asn residues prevented FPR glycosylation but not FPR expression in Sf9 membranes.	Asparagine	43-46	formyl peptide receptor 1	Homo sapiens	66-69
12557291-3	2003	This missense mutation causes an amino acid change from asparagine to glutamate (Asp27Glu) in the N-terminal region of the Cav-3 protein, which leads to a drastic decrease of Cav-3 protein expression in skeletal muscle tissue.	Asparagine	56-66	caveolin 3	Homo sapiens	175-180
12760422-7	2003	Identification of the ERK2 phosphorylation site Thr94 in bovine myelin basic protein reveals a nontraditional phosphate acceptor position, preceded by three noncharged residues (Asn-Ile-Val).	Asparagine	178-181	mitogen-activated protein kinase 1	Bos taurus	22-26
12626422-6	2003	It was found that asparagine 46 was always glycosylated and that asparagine 83 was never glycosylated in the underglycosylated glycoforms of alpha1-antitrypsin.	Asparagine	18-28	serpin family A member 1	Homo sapiens	141-159
12626422-7	2003	This showed that the asparagine residues are preferentially glycosylated in the order 46&gt;247&gt;83 in the mature underglycosylated forms of alpha1-antitrypsin found in plasma.	Asparagine	21-31	serpin family A member 1	Homo sapiens	143-161
12760422-7	2003	Identification of the ERK2 phosphorylation site Thr94 in bovine myelin basic protein reveals a nontraditional phosphate acceptor position, preceded by three noncharged residues (Asn-Ile-Val).	Asparagine	178-181	myelin basic protein	Bos taurus	64-84
12441350-7	2003	However, in the first inner loop, a substitution of three Ala residues for Met(128)-Arg(129)-Asn(130) abolished the ability to activate SRF only in F(q/11) cells, suggesting that this mutation might specifically disrupt the coupling to G(12/13) rather than to G(q/11).	Asparagine	93-96	serum response factor	Mus musculus	136-139
12620340-4	2003	AtAMI1 was expressed from its cDNA in enzymatically active form and exhibits substrate specificity for indole-3-acetamide, but also some activity against L-asparagine.	Asparagine	154-166	amidase 1	Arabidopsis thaliana	0-6
12579497-5	2003	RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08).	Asparagine	46-49	serpin family B member 3	Homo sapiens	132-135
12579497-5	2003	RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08).	Asparagine	70-73	serpin family B member 3	Homo sapiens	132-135
12579497-5	2003	RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08).	Asparagine	70-73	serpin family B member 3	Homo sapiens	132-135
12441350-9	2003	Therefore, we conclude that although the three intracellular loops of EDNRB may be involved in coupling to G proteins, residues Met(128)-Arg(129)-Asn(130) in the first intracellular loop are specifically required for activation of Galpha(13).	Asparagine	146-149	guanine nucleotide binding protein, alpha 13	Mus musculus	231-241
12517962-3	2003	The tapasin dependence of HLA class I alleles bearing different residues at position 114 decreases in the order of acidity, with high tapasin dependence for acidic amino acids (aspartic acid and glutamic acid), moderate dependence for neutral amino acids (asparagine and glutamine), and low dependence for basic amino acids (histidine and arginine).	Asparagine	256-266	TAP binding protein	Homo sapiens	4-11
12446723-2	2003	Under normoxic conditions, hydroxylation of proline residues triggers destruction of its alpha-subunit while hydroxylation of Asn(803) in the C-terminal transactivation domain of HIF-1 alpha (CAD) prevents its interaction with p300.	Asparagine	126-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-190
12511547-3	2003	Moreover, recent association studies suggested that a G/T polymorphism with an amino acid substitution (Lys/Asn) at codon 198 in exon 5 of the ET-1 gene interacts with body mass index (BMI) in association with blood pressure.	Asparagine	108-111	endothelin 1	Homo sapiens	143-147
12513997-3	2003	By introducing the mutant-derived genomic library into a non-L-proline-utilizing strain, the mutant was found to carry an allele of the wild-type PRO1 gene encoding gamma-glutamyl kinase, which resulted in a single amino acid replacement; Asp (GAC) at position 154 was replaced by Asn (AAC).	Asparagine	281-284	glutamate 5-kinase	Saccharomyces cerevisiae S288C	146-150
12350228-1	2003	The substitution of an active-site aspartic acid residue by asparagine in the lysosomal protease cathepsin D (CTSD) results in a loss of enzyme activity and severe cerebrocortical atrophy in a novel form of neuronal ceroid lipofuscinosis in sheep [Tyynela, Sohar, Sleat, Gin, Donnelly, Baumann, Haltia and Lobel (2000) EMBO J.	Asparagine	60-70	cathepsin D	Ovis aries	97-108
12350228-1	2003	The substitution of an active-site aspartic acid residue by asparagine in the lysosomal protease cathepsin D (CTSD) results in a loss of enzyme activity and severe cerebrocortical atrophy in a novel form of neuronal ceroid lipofuscinosis in sheep [Tyynela, Sohar, Sleat, Gin, Donnelly, Baumann, Haltia and Lobel (2000) EMBO J.	Asparagine	60-70	cathepsin D	Ovis aries	110-114
12605854-4	2003	Our data suggest that the causal mutation, a G to A transition, is localised in exon 2 of the MATP gene leading to an aspartic acid to asparagine substitution in the encoded protein.	Asparagine	135-145	solute carrier family 45 member 2	Equus caballus	94-98
12471154-4	2002	Mutation of the conserved Asp-759 in human eIF5B GTP-binding domain to Asn converts eIF5B to an XTPase and introduces an XTP requirement for subunit joining and translation initiation.	Asparagine	71-74	eukaryotic translation initiation factor 5B	Homo sapiens	43-48
15373684-4	2003	While the 378 C&gt;T and 624 T&gt;C are silent mutations, the 793A&gt;G polymorphism in codon 265 encodes asparagine for Doa and aspartic acid for Dob.	Asparagine	106-116	major histocompatibility complex, class II, DO beta	Homo sapiens	147-150
12943540-9	2003	Our results also indicate that the motif containing Asn-98 and specific charged residues in K1 (Glu-97 in PI and Arg-102 in AP3) are important for both the strength and specificity of AP3/PI heterodimer formation.	Asparagine	52-55	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	124-127
12943540-9	2003	Our results also indicate that the motif containing Asn-98 and specific charged residues in K1 (Glu-97 in PI and Arg-102 in AP3) are important for both the strength and specificity of AP3/PI heterodimer formation.	Asparagine	52-55	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	184-187
12471154-4	2002	Mutation of the conserved Asp-759 in human eIF5B GTP-binding domain to Asn converts eIF5B to an XTPase and introduces an XTP requirement for subunit joining and translation initiation.	Asparagine	71-74	eukaryotic translation initiation factor 5B	Homo sapiens	84-89
12417409-1	2002	UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I) and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II (GnT II) are key enzymes in the synthesis of Asn-linked hybrid and complex glycans.	Asparagine	232-235	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	88-93
12175333-7	2002	Moreover, transfecting CST mutants lacking both N-glycosylation sites, or only Asn-312, reduced significantly the amount of sulphatide synthesized, whereas substituting Asn-66 with a glutamine residue did not.	Asparagine	79-82	galactose-3-O-sulfotransferase 1	Mus musculus	23-26
12296770-4	2002	This gene, dgkA, encodes a deduced protein that contains three C1-type cysteine-rich repeats, a DGK catalytic domain most closely related to the theta subtype of mammalian DGKs and a C-terminal segment containing a proline/glutamine-rich region and a large aspargine-repeat region.	Asparagine	257-266	diacylglycerol kinase alpha	Homo sapiens	11-15
12524336-5	2002	The suppressing mutation in SPN1 substitutes an asparagine for an invariant lysine at position 192 (spn1(K192N)).	Asparagine	48-58	Spn1p	Saccharomyces cerevisiae S288C	28-32
12524336-5	2002	The suppressing mutation in SPN1 substitutes an asparagine for an invariant lysine at position 192 (spn1(K192N)).	Asparagine	48-58	Spn1p	Saccharomyces cerevisiae S288C	100-104
12426569-4	2002	In vitro functional analyses indicated that one SNP in the coding region of LTA, which changed an amino-acid residue from threonine to asparagine (Thr26Asn), effected a twofold increase in induction of several cell-adhesion molecules, including VCAM1, in vascular smooth-muscle cells of human coronary artery.	Asparagine	135-145	lymphotoxin alpha	Homo sapiens	76-79
12426569-4	2002	In vitro functional analyses indicated that one SNP in the coding region of LTA, which changed an amino-acid residue from threonine to asparagine (Thr26Asn), effected a twofold increase in induction of several cell-adhesion molecules, including VCAM1, in vascular smooth-muscle cells of human coronary artery.	Asparagine	135-145	vascular cell adhesion molecule 1	Homo sapiens	245-250
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Asparagine	284-287	sex hormone binding globulin	Homo sapiens	23-27
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Asparagine	284-287	complement C2	Homo sapiens	77-80
12228253-7	2002	By contrast, the low affinity of SHBG for 2-hydroxyestradiol can be attributed to intra-molecular hydrogen bonding between the hydroxyls in the aromatic steroid ring A, which generates a steric clash with the amido group of Asn(82).	Asparagine	224-227	sex hormone binding globulin	Homo sapiens	33-37
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Asparagine	200-203	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Asparagine	201-204	sex hormone binding globulin	Homo sapiens	21-25
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Asparagine	201-204	complement C3	Homo sapiens	99-102
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	106-109	bone morphogenetic protein 1	Homo sapiens	32-37
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	127-130	bone morphogenetic protein 1	Homo sapiens	32-37
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	127-130	bone morphogenetic protein 1	Homo sapiens	32-37
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	127-130	bone morphogenetic protein 1	Homo sapiens	32-37
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	127-130	bone morphogenetic protein 1	Homo sapiens	32-37
12218058-2	2002	Sequence analysis suggests that BMP-1 has six potential N-linked glycosylation sites (i.e. NXS/T) namely: Asn(91) (prodomain), Asn(142) (metalloproteinase domain), Asn(332) and Asn(363) (CUB1 domain), Asn(599) (CUB3 domain), and Asn(726) in the C-terminal-specific domain.	Asparagine	127-130	bone morphogenetic protein 1	Homo sapiens	32-37
12215170-0	2002	Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.	Asparagine	103-113	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	50-55
12355402-2	2002	The mutation occurs in the family in which the SPG10 locus was originally identified, at an invariant asparagine residue that, when mutated in orthologous kinesin heavy chain motor proteins, prevents stimulation of the motor ATPase by microtubule-binding.	Asparagine	102-112	kinesin family member 5A	Homo sapiens	47-52
12355402-2	2002	The mutation occurs in the family in which the SPG10 locus was originally identified, at an invariant asparagine residue that, when mutated in orthologous kinesin heavy chain motor proteins, prevents stimulation of the motor ATPase by microtubule-binding.	Asparagine	102-112	kinesin family member 5B	Homo sapiens	155-174
12215170-1	2002	Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction.	Asparagine	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-103
12215170-1	2002	Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction.	Asparagine	0-10	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	131-154
12215170-1	2002	Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction.	Asparagine	0-10	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	156-161
12215170-1	2002	Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction.	Asparagine	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	215-225
12215170-1	2002	Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction.	Asparagine	0-10	E1A binding protein p300	Homo sapiens	226-230
12196513-7	2002	Transfection of Rap1b mutants S17N (Ser --&gt; Asn) or T61R (Thr --&gt; Arg) in MCs inhibited the HG-induced increased FN synthesis.	Asparagine	47-50	RAP1B, member of RAS oncogene family	Rattus norvegicus	16-21
12856309-10	2002	We found that two signature candidate sites (Gly 174, Asn 175--human cathepsin L numbering) for cathepsin L-like group are conserved in PwCP5, which are conserved within cathepsin L-like group and also different from those of cruzipain and other cysteine proteinase groups.	Asparagine	54-57	cathepsin L	Homo sapiens	69-80
12856309-10	2002	We found that two signature candidate sites (Gly 174, Asn 175--human cathepsin L numbering) for cathepsin L-like group are conserved in PwCP5, which are conserved within cathepsin L-like group and also different from those of cruzipain and other cysteine proteinase groups.	Asparagine	54-57	cathepsin L	Homo sapiens	96-107
12856309-10	2002	We found that two signature candidate sites (Gly 174, Asn 175--human cathepsin L numbering) for cathepsin L-like group are conserved in PwCP5, which are conserved within cathepsin L-like group and also different from those of cruzipain and other cysteine proteinase groups.	Asparagine	54-57	cathepsin L	Homo sapiens	96-107
12196513-7	2002	Transfection of Rap1b mutants S17N (Ser --&gt; Asn) or T61R (Thr --&gt; Arg) in MCs inhibited the HG-induced increased FN synthesis.	Asparagine	47-50	fibronectin 1	Rattus norvegicus	119-121
12368358-2	2002	Using random mutagenesis of a chimera of maltose-binding protein and LEL residues 113 to 201, we have determined that the E2-binding site on CD81 comprises residues Ile(182), Phe(186), Asn(184), and Leu(162).	Asparagine	185-188	CD81 molecule	Homo sapiens	141-145
12372300-2	2002	Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the unstructured loop of Bcl-xL, and we demonstrate that deamidation of these asparagines imports susceptibility to apoptosis by disrupting the ability of Bcl-xL to block the proapoptotic activity of BH3 domain-only proteins.	Asparagine	141-152	BCL2 like 1	Homo sapiens	181-187
12406684-9	2002	In addition, the protein was biochemically and functionally similar to Asn(81)/Stop(155) expressed in insect cells concerning its oligomeric state and binding affinity to the lysosomal enzyme, beta-glucuronidase (K(d)=1.4nM).	Asparagine	71-74	glucuronidase beta	Homo sapiens	193-211
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Asparagine	37-47	E1A binding protein p300	Mus musculus	167-171
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Asparagine	37-47	CREB binding protein	Mus musculus	172-175
12485595-5	2002	The N-glycosylation sites are at asparagines in positions 38 and 120, the first site within the propeptide domain of the zymogenic form (pro-MMP-9) of the enzyme and the second in the catalytic domain.	Asparagine	33-44	matrix metallopeptidase 9	Homo sapiens	141-146
12145316-7	2002	Mutational analysis identified five of these residues (Lys-227, Asn-231, Asn-278, Lys-308, and Arg-312) as essential for Hsp90 binding.	Asparagine	64-67	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	121-126
12145316-7	2002	Mutational analysis identified five of these residues (Lys-227, Asn-231, Asn-278, Lys-308, and Arg-312) as essential for Hsp90 binding.	Asparagine	73-76	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	121-126
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Asparagine	44-54	cell division cycle 42	Homo sapiens	128-133
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Asparagine	44-54	cell division cycle 42	Homo sapiens	186-191
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Asparagine	44-54	cell division cycle 42	Homo sapiens	186-191
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Asparagine	44-54	cell division cycle 42	Homo sapiens	186-191
12372300-2	2002	Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the unstructured loop of Bcl-xL, and we demonstrate that deamidation of these asparagines imports susceptibility to apoptosis by disrupting the ability of Bcl-xL to block the proapoptotic activity of BH3 domain-only proteins.	Asparagine	141-152	BCL2 like 1	Homo sapiens	311-317
12372300-2	2002	Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the unstructured loop of Bcl-xL, and we demonstrate that deamidation of these asparagines imports susceptibility to apoptosis by disrupting the ability of Bcl-xL to block the proapoptotic activity of BH3 domain-only proteins.	Asparagine	234-245	BCL2 like 1	Homo sapiens	181-187
12372300-2	2002	Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the unstructured loop of Bcl-xL, and we demonstrate that deamidation of these asparagines imports susceptibility to apoptosis by disrupting the ability of Bcl-xL to block the proapoptotic activity of BH3 domain-only proteins.	Asparagine	234-245	BCL2 like 1	Homo sapiens	311-317
12323378-2	2002	In the crystal structure of AAG bound to DNA containing 1,N(6) ethenoadenine, an asparagine (N169) occupies the active-site floor, in close proximity to the C-2 position of the flipped-out 1,N(6) ethenoadenine.	Asparagine	81-91	N-methylpurine DNA glycosylase	Homo sapiens	28-31
12207467-1	2002	The cDNAs encoding chicken cystatin and its N-glycosylation-modified mutant (Asn(106)-Ile(108)--&gt;Asn(106)-Thr(108)) were cloned into the pGAPZ alpha C expression vector, using the GAP as promoter and Zeocin as resistant agent, and transformed into Pichia pastoris X-33 expression host.	Asparagine	77-80	cystatin C	Gallus gallus	27-35
12207467-1	2002	The cDNAs encoding chicken cystatin and its N-glycosylation-modified mutant (Asn(106)-Ile(108)--&gt;Asn(106)-Thr(108)) were cloned into the pGAPZ alpha C expression vector, using the GAP as promoter and Zeocin as resistant agent, and transformed into Pichia pastoris X-33 expression host.	Asparagine	100-103	cystatin C	Gallus gallus	27-35
12207467-7	2002	However, N-glycosylation at Asn(106) substantially enhanced the freezing stability of recombinant chicken cystatin overexpressed in P. pastoris.	Asparagine	28-31	cystatin C	Gallus gallus	106-114
12176055-6	2002	Moreover, sequence comparisons showed that within this C-terminal region a conserved acidic residue (Asp 59) in yeast IF(1) is replaced by Asn in STF(1).	Asparagine	139-142	ATPase-binding protein	Saccharomyces cerevisiae S288C	146-152
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Asparagine	21-24	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Asparagine	28-31	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Asparagine	28-31	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12297292-1	2002	L-Asparaginase is known to catalyze the hydrolysis of L-asparagine to L-aspartic and ammonia, but little is known about its action on peptides.	Asparagine	54-66	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
12093813-3	2002	In addition, immunochemical analysis of red blood cells demonstrated that hUT-B1 also exhibits ABO determinants attached to the single N-linked sugar chain at Asn-211.	Asparagine	159-162	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	74-80
12070151-7	2002	mAChR activation also induces GTP-independent changes in Rac1 because mAChR activation redistributes HA-Rac1(Asn-17), which does not bind GTP.	Asparagine	109-112	ras-related C3 botulinum toxin substrate 1	Cricetulus griseus	57-61
12070151-7	2002	mAChR activation also induces GTP-independent changes in Rac1 because mAChR activation redistributes HA-Rac1(Asn-17), which does not bind GTP.	Asparagine	109-112	ras-related C3 botulinum toxin substrate 1	Cricetulus griseus	104-108
12225802-0	2002	Isolation of ovocleidin-116 from chicken eggshells, correction of its amino acid sequence and identification of disulfide bonds and glycosylated Asn.	Asparagine	145-148	matrix extracellular phosphoglycoprotein	Gallus gallus	13-27
12193273-3	2002	RESULTS: Truncation and mutagenesis approaches showed that the RACK1-interacting domain on PDE4D5 comprised a cluster of residues provided by Asn-22/Pro-23/Trp-24/Asn-26 together with a series of hydrophobic amino acids, namely Leu-29, Val-30, Leu-33, Leu-37 and Leu-38 in a "Leu-Xaa-Xaa-Xaa-Leu" repeat.	Asparagine	142-145	receptor for activated C kinase 1	Mus musculus	63-68
12193273-3	2002	RESULTS: Truncation and mutagenesis approaches showed that the RACK1-interacting domain on PDE4D5 comprised a cluster of residues provided by Asn-22/Pro-23/Trp-24/Asn-26 together with a series of hydrophobic amino acids, namely Leu-29, Val-30, Leu-33, Leu-37 and Leu-38 in a "Leu-Xaa-Xaa-Xaa-Leu" repeat.	Asparagine	163-166	receptor for activated C kinase 1	Mus musculus	63-68
12235182-2	2002	Substituting Asn residue with Gln at the single glycosylation site within apoB-17 (N(158)) decreased its secretion efficiency to a level equivalent to that of wild-type apoB-17 treated with tunicamycin, but had little effect on its synthesis or intracellular distribution.	Asparagine	13-16	apolipoprotein B	Homo sapiens	74-78
12200473-1	2002	On the basis of the analysis of 64 glycosyltransferases from 14 species we propose that several successive duplications of a common ancestral gene, followed by divergent evolution, have generated the mannosyltransferases and the glucosyltransferases involved in asparagine-linked glycosylation (ALG) and phosphatidyl-inositol glycan anchor (PIG or GPI), which use lipid-related donor and acceptor substrates.	Asparagine	262-272	glucose-6-phosphate isomerase	Sus scrofa	348-351
12202623-7	2002	An A--&gt;T polymorphism in mRNA (tenascin gene, A(2366)--&gt;T, Asn--&gt;Ile) and a G--&gt;A polymorphism in genomic DNA (Ku gene, G(74582)--&gt;A, Val--&gt;Ile), both of which generate a restriction site for the enzyme SAU3A1, demonstrate the application.	Asparagine	65-68	tenascin C	Homo sapiens	34-42
12070159-5	2002	The results suggest that constitutive LHR activation by mutations at Asp-556(6.44) is triggered by the breakage or weakening of the interaction found in the wild type receptor between Asp-556(6.44) and Asn-593(7.45).	Asparagine	202-205	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	38-41
12097605-1	2002	Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4.	Asparagine	144-154	CD4 molecule	Homo sapiens	96-99
12142634-2	2002	L-Asparagine is an essential amino acid for many lymphoid tumor cells and L-asparaginase catalyzes its conversion to L-aspartic acid and ammonia.	Asparagine	0-12	asparaginase and isoaspartyl peptidase 1	Homo sapiens	74-88
12240950-0	2002	Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.	Asparagine	20-30	interleukin 11	Homo sapiens	92-106
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Asparagine	93-96	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74
12205739-4	2002	alphaMSH analogues [(6)His]alphaMSH-ND and [(6)Asn]alphaMSH-ND were synthesized and the radio-ligand receptor binding- and cyclic AMP generating activity were analyzed in China Hamster Ovary cell line over- expressing melanocortin receptors.	Asparagine	47-50	proopiomelanocortin	Rattus norvegicus	0-8
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Asparagine	97-100	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	9-15
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Asparagine	97-100	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	69-73
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Asparagine	97-100	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	168-172
12042299-3	2002	Hydroxylation of an asparagine residue in the C-terminal transactivation domain (CAD) of HIF-alpha abrogates interaction with p300, preventing transcriptional activation.	Asparagine	20-30	E1A binding protein p300	Homo sapiens	126-130
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Asparagine	134-137	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74
12004058-0	2002	The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.	Asparagine	24-34	nuclear receptor subfamily 1 group H member 4	Homo sapiens	67-87
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Asparagine	134-137	nuclear receptor subfamily 1 group H member 4	Homo sapiens	124-127
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Asparagine	134-137	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Asparagine	31-34	nuclear receptor subfamily 1, group H, member 4	Mus musculus	82-85
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Asparagine	31-34	nuclear receptor subfamily 1, group H, member 4	Mus musculus	111-114
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Asparagine	31-34	nuclear receptor subfamily 1 group H member 4	Homo sapiens	111-114
12060683-1	2002	The second and third amino acid residues of the N-terminal arm of most Hox protein homeodomains are basic (lysine or arginine), whereas they are asparagine and alanine, respectively, in the Hoxa1 homeodomain.	Asparagine	145-155	homeobox A1	Homo sapiens	190-195
12087059-3	2002	We found for the first time that Edg-1 is glycosylated in its amino-terminal extracellular portion, and further identified the specific glycosylation site as asparagine 30 by creating a nonglycosylated mutant of Edg-1 (N30D-Edg-1) and transfecting it into cell lines.	Asparagine	158-168	sphingosine-1-phosphate receptor 1	Homo sapiens	33-38
12087059-3	2002	We found for the first time that Edg-1 is glycosylated in its amino-terminal extracellular portion, and further identified the specific glycosylation site as asparagine 30 by creating a nonglycosylated mutant of Edg-1 (N30D-Edg-1) and transfecting it into cell lines.	Asparagine	158-168	sphingosine-1-phosphate receptor 1	Homo sapiens	212-217
14993394-3	2002	Oxygen-dependent hydroxylation of conserved proline and asparagine residues in HIF-alpha are required for targeting HIF-alpha to proteasomes for destruction, and for inhibiting its capacity for CBP/p300-dependent transactivation, respectively.	Asparagine	56-66	CREB binding protein	Homo sapiens	194-202
11994306-7	2002	Here we have investigated the relationship between the two N-linked glycosylation sites (Asn(10) and Asn(1050)) and SUR1 trafficking.	Asparagine	89-92	ATP binding cassette subfamily C member 8	Homo sapiens	116-120
11994306-7	2002	Here we have investigated the relationship between the two N-linked glycosylation sites (Asn(10) and Asn(1050)) and SUR1 trafficking.	Asparagine	101-104	ATP binding cassette subfamily C member 8	Homo sapiens	116-120
12060683-4	2002	Here, we have analysed the transcriptional activity of a Hoxa1(NA-KR) mutant for which the asparagine and alanine residues of the homeodomain have been replaced by lysine and arginine, respectively.	Asparagine	91-101	homeobox A1	Homo sapiens	57-62
12044886-4	2002	Our data indicate that the functional specificity of NeuroD to define sensory neurons is mainly due to a single residue (asparagine 11) in its basic domain.	Asparagine	121-131	neuronal differentiation 1	Danio rerio	53-59
12034574-6	2002	The difference in mass is due to the presence of an Asparagine-linked glycosylation in the carbohydrate recognition domain of porcine SP-D, which is absent in SP-D of other species investigated so far.	Asparagine	52-62	surfactant protein D	Homo sapiens	134-138
12023892-1	2002	Glycosylation of Asn-52 of the alpha-subunit (alphaAsn-52) is required for bioactivity of the alphabeta-dimeric human chorionic gonadotropin (hCG), although at a molecular level the effect of the glycan at alphaAsn-52 is not yet understood.	Asparagine	17-20	chorionic gonadotropin subunit beta 5	Homo sapiens	142-145
12009425-4	2002	One mutation was a G3295T substitution with conversion of asparagine to tyrosine (D1099Y) in ABCA1.	Asparagine	58-68	ATP binding cassette subfamily A member 1	Homo sapiens	93-98
12455997-2	2002	Before protein conjugation, the carboxyl-terminal asparagine residue of Rub1p is removed.	Asparagine	50-60	NEDD8 family protein RUB1	Saccharomyces cerevisiae S288C	72-77
12455997-3	2002	Rub1p conjugation is dependent on the carboxyl-terminal processing enzyme Yuh1p, whereas Rub1p lacking the asparagine residue is conjugated without Yuh1p.	Asparagine	107-117	NEDD8 family protein RUB1	Saccharomyces cerevisiae S288C	89-94
12012328-6	2002	Eight out of 14 patients including above 4 patients demonstrated a common deletion of the G-CSFR cDNA; a deletion of three nucleotides (2128-2130) in the juxtamembrane domain of the G-CSFR, which resulted in a conversion of Asn(630)Arg(631) to Lys(630).	Asparagine	224-227	colony stimulating factor 3 receptor	Homo sapiens	90-96
12068109-9	2002	Two aat2 mutants show dramatic decreases in Asp and asparagine levels in leaves and/or siliques.	Asparagine	52-62	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
11882663-4	2002	In the PDZ1-beta(2)AR complex, the side chain of asparagine at position -4 in the beta(2)AR peptide forms two additional hydrogen bonds with Gly(30) of PDZ1, which contribute to the higher affinity of this interaction.	Asparagine	49-59	adrenoceptor beta 2	Homo sapiens	12-21
11882663-4	2002	In the PDZ1-beta(2)AR complex, the side chain of asparagine at position -4 in the beta(2)AR peptide forms two additional hydrogen bonds with Gly(30) of PDZ1, which contribute to the higher affinity of this interaction.	Asparagine	49-59	adrenoceptor beta 2	Homo sapiens	82-91
12036910-10	2002	A conformational change in hAGT, which involves opening of an asparagine hinge, normally occurs after alkylation of the protein in its role in DNA repair and causes degradation of the alkylated hAGT.	Asparagine	62-72	angiotensinogen	Homo sapiens	27-31
12036910-10	2002	A conformational change in hAGT, which involves opening of an asparagine hinge, normally occurs after alkylation of the protein in its role in DNA repair and causes degradation of the alkylated hAGT.	Asparagine	62-72	angiotensinogen	Homo sapiens	194-198
11993999-2	2002	Here the equivalent residue, Phe(282), in the beta(2)-AR was evaluated by mutation to glycine, asparagine, alanine, or leucine.	Asparagine	95-105	adrenoceptor beta 2	Homo sapiens	46-56
11877385-2	2002	The FRS2 PTB domain recognizes tyrosine-phosphorylated TRKs at an NPXpY (where pY is phosphotyrosine) motif, whereas its constitutive association with FGFR involves a receptor juxtamembrane region lacking Tyr and Asn residues.	Asparagine	213-216	fibroblast growth factor receptor substrate 2	Homo sapiens	4-8
11827963-4	2002	Two important amino acid residues (Asn(263) in sensor 1 and Arg(332) in sensor 2) were identified as key residues for Cdc6p function in vivo.	Asparagine	35-38	AAA family ATPase CDC6	Saccharomyces cerevisiae S288C	118-123
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	196-203
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	TIMP metallopeptidase inhibitor 1	Homo sapiens	217-223
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	TIMP metallopeptidase inhibitor 2	Homo sapiens	228-234
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	matrix metallopeptidase 3	Homo sapiens	275-280
11854269-4	2002	We show here, in digests with native human aggrecan, that purified ADAMTS4 cleaves primarily at the Glu(373)-Ala(374) site, but also, albeit slowly and secondarily, at the Asn(341)-Phe(342) site.	Asparagine	172-175	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	67-74
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	81-88
11854269-5	2002	Cleavage at the Asn(341)-Phe(342) site in these incubations was due to bona fide ADAMTS4 activity (and not a contaminating MMP) because the cleavage was inhibited by TIMP-3 (a potent inhibitor of ADAMTS4), but not by TIMP-1 and TIMP-2, at concentrations that totally blocked MMP-3-mediated cleavage at this site.	Asparagine	16-19	TIMP metallopeptidase inhibitor 3	Homo sapiens	166-172
11996884-10	2002	Individual mutations of the three residues where rAGT and mAGT differ in this region showed that the principal reason for the reduced ability of the mAGT to react with BG was the presence of a histidine residue at position 161, which is occupied by asparagine in rAGT and hAGT.	Asparagine	249-259	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	58-62
11959990-5	2002	The structure reveals the mechanism of specific recognition of p300 by HIF-1 alpha, and shows how HIF-1 alpha transactivation is regulated by asparagine hydroxylation.	Asparagine	142-152	E1A binding protein p300	Homo sapiens	63-67
11959990-5	2002	The structure reveals the mechanism of specific recognition of p300 by HIF-1 alpha, and shows how HIF-1 alpha transactivation is regulated by asparagine hydroxylation.	Asparagine	142-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-82
11959990-5	2002	The structure reveals the mechanism of specific recognition of p300 by HIF-1 alpha, and shows how HIF-1 alpha transactivation is regulated by asparagine hydroxylation.	Asparagine	142-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-109
12062436-0	2002	A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.	Asparagine	12-15	thyroid stimulating hormone receptor	Homo sapiens	30-50
11996884-10	2002	Individual mutations of the three residues where rAGT and mAGT differ in this region showed that the principal reason for the reduced ability of the mAGT to react with BG was the presence of a histidine residue at position 161, which is occupied by asparagine in rAGT and hAGT.	Asparagine	249-259	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	149-153
11960015-0	2002	Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.	Asparagine	94-104	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	121-126
11960015-2	2002	Aggregation of the yeast Sup35 protein into prions has been attributed to its glutamine-rich and asparagine-rich domain.	Asparagine	97-107	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	25-30
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 2 receptor, gamma chain	Mus musculus	59-67
11944920-2	2002	Hb Zurich-Hottingen is characterized by an Asn --> Ser replacement in the alpha-chain at position 9 as confirmed by DNA analysis.	Asparagine	43-46	Fc gamma receptor and transporter	Homo sapiens	74-85
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 2 receptor, gamma chain	Mus musculus	136-144
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 2	Mus musculus	224-228
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 7	Mus musculus	230-234
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 15	Mus musculus	240-245
11914074-3	2002	Pulse-chase labeling experiments in BHK-21 cells demonstrate that the alpha(1B)-AR is synthesized as a 70 kDa core glycosylated precursor that is converted to the 90 kDa mature form of the receptor with a half-time of approximately 2 h. N-Linked glycosylation of the alpha(1B)-AR occurs at four asparagines on the N-terminus of the receptor.	Asparagine	295-306	adrenoceptor alpha 1B	Homo sapiens	80-82
11815609-3	2002	In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification of Asn-128 of mouse gamma(c) that represents another potential contact residue that is required for binding IL-2, IL-7, and IL-15 but not IL-4.	Asparagine	119-122	interleukin 4	Mus musculus	254-258
11983426-11	2002	The enzyme also cleaved an N-terminal synthetic peptide of bovine annexin II (Gly(24)-Ser-Val-Lys-Ala-Tyr-Thr(30)-Asn-Phe-Asp-Ala-Glu(35)-Arg-Asp(37)) at a position between Asn(31) and Phe(32).	Asparagine	114-117	annexin A2	Bos taurus	66-76
12047225-6	2002	Sequencing of the CSTB alleles showed a missense mutation that changes a codon for aspartic acid into a codon for asparagine in exon 3 of the gene.	Asparagine	114-124	cystatin B	Sus scrofa	18-22
11983428-4	2002	We have confirmed that STIM1 is modified by N-linked glycosylation at two sites within the SAM domain itself, deduced as asparagine residues N131 and N171, demonstrating that STIM1 is translocated across the membrane of the endoplasmic reticulum such that the SAM domain resides within the endoplasmic reticulum (ER) lumen.	Asparagine	121-131	stromal interaction molecule 1	Homo sapiens	23-28
11983426-11	2002	The enzyme also cleaved an N-terminal synthetic peptide of bovine annexin II (Gly(24)-Ser-Val-Lys-Ala-Tyr-Thr(30)-Asn-Phe-Asp-Ala-Glu(35)-Arg-Asp(37)) at a position between Asn(31) and Phe(32).	Asparagine	173-176	annexin A2	Bos taurus	66-76
11983428-4	2002	We have confirmed that STIM1 is modified by N-linked glycosylation at two sites within the SAM domain itself, deduced as asparagine residues N131 and N171, demonstrating that STIM1 is translocated across the membrane of the endoplasmic reticulum such that the SAM domain resides within the endoplasmic reticulum (ER) lumen.	Asparagine	121-131	stromal interaction molecule 1	Homo sapiens	175-180
11888200-4	2002	On basis of the monosaccharide composition and MALDI-MS analysis of native and PNGase-F-treated chymotryptic glycopeptide fragment of RtH2-e the oligosaccharide Man(5)GlcNAc(2), attached to Asn(127), is suggested.	Asparagine	190-193	N-glycanase 1	Homo sapiens	79-85
12297037-1	2002	Replacement of the Asp-84 residue of the deoxyguanosine kinase subunit of the tandem deoxyadenosine kinase/ deoxyguanosine kinase (dAK/dGK) from Lactobacillus acidophilus R-26 by Ala, Asn, or Glu produced increased Km values for deoxyguanosine on dGK.	Asparagine	184-187	Diacyl glycerol kinase	Drosophila melanogaster	135-138
12039072-1	2002	Human sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein, and each SHBG monomer may have an O-linked oligosaccharide at Thr(7) and up to two N-linked oligosaccharides at Asn(351) and Asn(367).	Asparagine	192-195	sex hormone binding globulin	Homo sapiens	6-34
12039072-1	2002	Human sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein, and each SHBG monomer may have an O-linked oligosaccharide at Thr(7) and up to two N-linked oligosaccharides at Asn(351) and Asn(367).	Asparagine	192-195	sex hormone binding globulin	Homo sapiens	36-40
12039072-1	2002	Human sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein, and each SHBG monomer may have an O-linked oligosaccharide at Thr(7) and up to two N-linked oligosaccharides at Asn(351) and Asn(367).	Asparagine	205-208	sex hormone binding globulin	Homo sapiens	6-34
12039072-1	2002	Human sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein, and each SHBG monomer may have an O-linked oligosaccharide at Thr(7) and up to two N-linked oligosaccharides at Asn(351) and Asn(367).	Asparagine	205-208	sex hormone binding globulin	Homo sapiens	36-40
12174217-2	2002	By sequencing the coding region of AGM(1), two alleles containing a G or A base at nucleotide 1396, that can respectively encode aspartic acid or asparagine at codon 466, were identified.	Asparagine	146-156	phosphoglucomutase 3	Homo sapiens	35-41
11844751-8	2002	Exchange of this His residue for Asn led to inactivation of MrsD.	Asparagine	33-36	MRSD	Homo sapiens	60-64
11875050-7	2002	DNA sequencing of affected individuals from the two American RP10 families revealed a GAC--&gt;AAC transition in codon 226 substituting an asparagine for an aspartic acid in both families.	Asparagine	139-149	inosine monophosphate dehydrogenase 1	Homo sapiens	61-65
11834450-4	2002	Membrane-associated GHBP and soluble GHBP appear to be identical polypeptides distinguished by the addition of different N-glycans to asparagine residues.	Asparagine	134-144	growth hormone receptor	Mus musculus	20-24
11841215-2	2002	In wild-type (WT) BPTI, Gly 37 HN is in an unusual NH-aromatic-NH network of interactions with the ring of Tyr 35 and the side chain HN of Asn 44.	Asparagine	139-142	spleen trypsin inhibitor I	Bos taurus	18-22
11884082-6	2002	Twelve cysteine residues, forming six disulfide bonds within beta-subunit and two putative asparagine-linked glycosylation sites, are also conserved in the chicken FSH-beta-subunit.	Asparagine	91-101	follicle stimulating hormone beta subunit	Gallus gallus	164-172
11854433-4	2002	Mutations at the critical asparagine residues in the M2 loop of NR1 and NR2B and at a tryptophan residue in M2 of NR2B reduced block by MK-801, memantine, and TB-3-4.	Asparagine	26-36	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	64-67
11854433-4	2002	Mutations at the critical asparagine residues in the M2 loop of NR1 and NR2B and at a tryptophan residue in M2 of NR2B reduced block by MK-801, memantine, and TB-3-4.	Asparagine	26-36	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	72-76
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Asparagine	189-192	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	20-28
11741940-8	2002	Analysis of glycosylation sites showed that sFRP-1 contains a relatively large carbohydrate moiety on Asn(172) (approximately 2.8 kDa), whereas Asn(262), the second potential N-linked glycosylation site, is not modified.	Asparagine	102-105	secreted frizzled related protein 1	Homo sapiens	44-50
11820929-4	2002	Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side.	Asparagine	116-119	cytochrome b	Bos taurus	48-60
11820929-4	2002	Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side.	Asparagine	116-119	cytochrome b	Bos taurus	172-184
11834450-4	2002	Membrane-associated GHBP and soluble GHBP appear to be identical polypeptides distinguished by the addition of different N-glycans to asparagine residues.	Asparagine	134-144	growth hormone receptor	Mus musculus	37-41
12017288-0	2002	Stimulation of arginine consumption and asparagine production in LPS-activated macrophages.	Asparagine	40-50	toll-like receptor 4	Mus musculus	65-68
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	COP9 signalosome subunit 5	Homo sapiens	116-120
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	COP9 signalosome subunit 5	Homo sapiens	121-125
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	dynactin subunit 6	Homo sapiens	144-147
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	COP9 signalosome subunit 5	Homo sapiens	183-187
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	COP9 signalosome subunit 5	Homo sapiens	188-192
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Asparagine	79-89	dynactin subunit 6	Homo sapiens	220-223
11823643-4	2002	Inhibitors of Fe(II)- and 2-oxoglutarate-dependent dioxygenases prevented hydroxylation of the Asn, thus allowing the CAD to interact with the p300 transcription coactivator.	Asparagine	95-98	E1A binding protein p300	Homo sapiens	143-147
11823643-5	2002	Replacement of the conserved Asn by Ala resulted in constitutive p300 interaction and strong transcriptional activity.	Asparagine	29-32	E1A binding protein p300	Homo sapiens	65-69
11823643-6	2002	Full induction of HIF-1alpha and -2alpha, therefore, relies on the abrogation of both Pro and Asn hydroxylation, which during normoxia occur at the degradation and COOH-terminal transactivation domains, respectively.	Asparagine	94-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-40
12017288-4	2002	When Raw264.7 cells were incubated with 10 or 100 ng/mL LPS, the consumption of arginine and the production of citrulline, nitric oxide (NO) and asparagine were significantly increased.	Asparagine	145-155	toll-like receptor 4	Mus musculus	56-59
11864713-1	2002	The N-glycosylation site mutants of human protein C inhibitor (PCI; N230S, N243Q, N319Q, N230S/N243Q, and N230S/N319Q) were prepared by amino acid replacement of the asparagine residue with a serine or glutamine residue using site-directed mutagenesis and expressed in the baculovirus/insect cell expression system.	Asparagine	166-176	serpin family A member 5	Homo sapiens	42-61
11744994-6	2002	From this we discovered a previously unknown hemizygous mutation (A--&gt;T) in exon 4 of the androgen receptor gene, associated with replacement of asparagine (AAT) with tyrosine (TAT) in the resultant androgen receptor protein [N705Y].	Asparagine	148-158	androgen receptor	Homo sapiens	93-110
11744994-6	2002	From this we discovered a previously unknown hemizygous mutation (A--&gt;T) in exon 4 of the androgen receptor gene, associated with replacement of asparagine (AAT) with tyrosine (TAT) in the resultant androgen receptor protein [N705Y].	Asparagine	148-158	serpin family A member 1	Homo sapiens	160-163
11744994-6	2002	From this we discovered a previously unknown hemizygous mutation (A--&gt;T) in exon 4 of the androgen receptor gene, associated with replacement of asparagine (AAT) with tyrosine (TAT) in the resultant androgen receptor protein [N705Y].	Asparagine	148-158	androgen receptor	Homo sapiens	202-219
12111653-0	2002	Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia.	Asparagine	51-54	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	25-30
12111653-0	2002	Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia.	Asparagine	51-54	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-30
12483248-4	2002	The activity of PSTI protein with a point mutation of the most common type: (34)Asn (AAT)-to-Ser (AGT)(101A&gt;G N34S: N34S) in exon 3, was compared with that of the wild type.	Asparagine	80-83	serine peptidase inhibitor Kazal type 1	Homo sapiens	16-20
12483248-4	2002	The activity of PSTI protein with a point mutation of the most common type: (34)Asn (AAT)-to-Ser (AGT)(101A&gt;G N34S: N34S) in exon 3, was compared with that of the wild type.	Asparagine	80-83	serpin family A member 1	Homo sapiens	85-88
11698233-4	2001	When expressed in Xenopus laevis oocytes and in mammalian cells, rat SN2 mediates Na(+)-dependent transport of several neutral amino acids, including glycine, asparagine, alanine, serine, glutamine, and histidine.	Asparagine	159-169	solute carrier family 38, member 5	Rattus norvegicus	69-72
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Asparagine	178-181	Rac family small GTPase 1	Homo sapiens	24-28
11926005-4	2002	The key dhfr mutation associated with pyrimethamine resistance, Asn-108, was found in 4 isolates.	Asparagine	64-67	dihydrofolate reductase	Homo sapiens	8-12
11732900-2	2001	A basic nitrogen was introduced into a general PTP inhibitor to form a salt bridge to Asp48 in PTP1B and simultaneously cause repulsion in PTPs containing an asparagine in the equivalent position [Iversen, L. F., et al.	Asparagine	158-168	protein tyrosine phosphatase receptor type U	Homo sapiens	47-50
11732900-2	2001	A basic nitrogen was introduced into a general PTP inhibitor to form a salt bridge to Asp48 in PTP1B and simultaneously cause repulsion in PTPs containing an asparagine in the equivalent position [Iversen, L. F., et al.	Asparagine	158-168	6-pyruvoyltetrahydropterin synthase	Homo sapiens	139-143
11724556-0	2001	Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.	Asparagine	9-19	glutamyl aminopeptidase	Homo sapiens	27-43
11724556-5	2001	In carboxypeptidase A (EC 3.4.17.1, CPA), the exopeptidase specificity is conferred by an arginine residue (Arg-145) and an asparagine residue (Asn-144).	Asparagine	124-134	carboxypeptidase A1	Homo sapiens	36-39
11724556-5	2001	In carboxypeptidase A (EC 3.4.17.1, CPA), the exopeptidase specificity is conferred by an arginine residue (Arg-145) and an asparagine residue (Asn-144).	Asparagine	144-147	carboxypeptidase A1	Homo sapiens	36-39
11724556-6	2001	Thus, we hypothesized that Asn-353 of the GXMEN motif in APA plays a similar role to Asn-144 in CPA and contributes to the exopeptidase specificity of APA.	Asparagine	27-30	carboxypeptidase A1	Homo sapiens	96-99
11724556-6	2001	Thus, we hypothesized that Asn-353 of the GXMEN motif in APA plays a similar role to Asn-144 in CPA and contributes to the exopeptidase specificity of APA.	Asparagine	85-88	carboxypeptidase A1	Homo sapiens	96-99
11724556-14	2001	In conclusion, Asn-353 of the GXMEN motif, together with Glu-352, contributes to the exopeptidase specificity of APA and plays an equivalent role to Asn-144 in CPA.	Asparagine	15-18	carboxypeptidase A1	Homo sapiens	160-163
11724556-14	2001	In conclusion, Asn-353 of the GXMEN motif, together with Glu-352, contributes to the exopeptidase specificity of APA and plays an equivalent role to Asn-144 in CPA.	Asparagine	149-152	carboxypeptidase A1	Homo sapiens	160-163
11737209-1	2001	Enzymatic properties of barley alpha-amylase 1 (AMY1) are altered as a result of amino acid substitutions at subsites -5/-6 (Cys95--&gt;Ala/Thr) and +1/+2 (Met298--&gt;Ala/Asn/Ser) as well as in the double mutants, Cys95--&gt;Ala/Met298--&gt;Ala/Asn/Ser.	Asparagine	172-175	LOC548210	Hordeum vulgare	31-46
11908926-9	2001	Whereas the relationship between the clinical pharmacology, and potentially important pharmacodynamic effects such as asparagine depletion, has been well characterized for therapy with L-asparaginase, similar studies have yet to be performed for the other drugs that form the mainstay of remission induction therapy for childhood ALL.	Asparagine	118-128	asparaginase and isoaspartyl peptidase 1	Homo sapiens	185-199
11737209-1	2001	Enzymatic properties of barley alpha-amylase 1 (AMY1) are altered as a result of amino acid substitutions at subsites -5/-6 (Cys95--&gt;Ala/Thr) and +1/+2 (Met298--&gt;Ala/Asn/Ser) as well as in the double mutants, Cys95--&gt;Ala/Met298--&gt;Ala/Asn/Ser.	Asparagine	172-175	LOC548210	Hordeum vulgare	48-52
11737209-1	2001	Enzymatic properties of barley alpha-amylase 1 (AMY1) are altered as a result of amino acid substitutions at subsites -5/-6 (Cys95--&gt;Ala/Thr) and +1/+2 (Met298--&gt;Ala/Asn/Ser) as well as in the double mutants, Cys95--&gt;Ala/Met298--&gt;Ala/Asn/Ser.	Asparagine	246-249	LOC548210	Hordeum vulgare	31-46
11737209-1	2001	Enzymatic properties of barley alpha-amylase 1 (AMY1) are altered as a result of amino acid substitutions at subsites -5/-6 (Cys95--&gt;Ala/Thr) and +1/+2 (Met298--&gt;Ala/Asn/Ser) as well as in the double mutants, Cys95--&gt;Ala/Met298--&gt;Ala/Asn/Ser.	Asparagine	246-249	LOC548210	Hordeum vulgare	48-52
11859928-1	2001	The conserved residues Y239 and L240 of human VPAC1 receptor are predicted to be at the same location as the asparagine and arginine in the "DRY" motif in the Rhodopsin family of G protein-coupled receptors.	Asparagine	109-119	vasoactive intestinal peptide receptor 1	Homo sapiens	46-60
11745393-0	2001	Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.	Asparagine	19-29	myelin basic protein	Homo sapiens	97-117
11814014-1	2001	The presence of glycan at Asn-281 in bovine lactoferrin-a, which has a higher molecular weight than regular lactoferrin-b, was found in our previous study.	Asparagine	26-29	lactotransferrin	Bos taurus	44-55
11814014-1	2001	The presence of glycan at Asn-281 in bovine lactoferrin-a, which has a higher molecular weight than regular lactoferrin-b, was found in our previous study.	Asparagine	26-29	lactotransferrin	Bos taurus	108-119
11814014-3	2001	In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones.	Asparagine	40-43	lactotransferrin	Bos taurus	3-14
11814014-3	2001	In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones.	Asparagine	52-55	lactotransferrin	Bos taurus	3-14
11814014-3	2001	In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones.	Asparagine	52-55	lactotransferrin	Bos taurus	3-14
11814014-3	2001	In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones.	Asparagine	52-55	lactotransferrin	Bos taurus	3-14
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Asparagine	144-147	lactotransferrin	Bos taurus	45-56
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Asparagine	144-147	lactotransferrin	Bos taurus	70-81
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Asparagine	153-156	lactotransferrin	Bos taurus	70-81
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Asparagine	153-156	lactotransferrin	Bos taurus	70-81
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Asparagine	153-156	lactotransferrin	Bos taurus	70-81
11814014-6	2001	In addition, analysis of the structure of the glycan bound to Asn-281 present only in lactoferrin-a showed it possessed the heterogeneous structure of a complex-type glycan in which the structures Man3GlcNAc2, Man3GlcNAc4, Man3GlcNAc4Fuc are suggested to be present based on HPLC retention times only.	Asparagine	62-65	lactotransferrin	Bos taurus	86-97
11859928-1	2001	The conserved residues Y239 and L240 of human VPAC1 receptor are predicted to be at the same location as the asparagine and arginine in the "DRY" motif in the Rhodopsin family of G protein-coupled receptors.	Asparagine	109-119	rhodopsin	Homo sapiens	159-168
11698587-6	2001	We found that the mutation of aspartate to asparagine (CB1-D164N) abolished G-protein sequestration and constitutive receptor activity without disrupting agonist-stimulated activity.	Asparagine	43-53	cannabinoid receptor 1	Homo sapiens	55-58
11527975-6	2001	SKCa3 was rendered sensitive to Lei-Dab(7) by replacing His(521) with the corresponding SKCa2 residue (Asn(367)).	Asparagine	103-106	potassium calcium-activated channel subfamily N member 3	Homo sapiens	0-5
11527975-6	2001	SKCa3 was rendered sensitive to Lei-Dab(7) by replacing His(521) with the corresponding SKCa2 residue (Asn(367)).	Asparagine	103-106	potassium calcium-activated channel subfamily N member 2	Homo sapiens	88-93
11590543-10	2001	Interestingly, CGI-58 differs from other members of the esterase/lipase/thioesterase subfamily in that its putative catalytic triad contains an asparagine in place of the usual serine residue.	Asparagine	144-154	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	Homo sapiens	15-21
11709091-3	2001	To further examine its role in viral infection, we introduced a conservative amino acid substitution (asparagine to glutamine) in the V3-proximal glycosylation motif (Asn-X-Ser/Thr) in the surface glycoprotein of a CXCR4-using virus (BRU), a CCR5-using virus (SF162), and a dual-tropic virus (89.6).	Asparagine	102-112	C-X-C motif chemokine receptor 4	Homo sapiens	215-220
11709091-3	2001	To further examine its role in viral infection, we introduced a conservative amino acid substitution (asparagine to glutamine) in the V3-proximal glycosylation motif (Asn-X-Ser/Thr) in the surface glycoprotein of a CXCR4-using virus (BRU), a CCR5-using virus (SF162), and a dual-tropic virus (89.6).	Asparagine	102-112	C-C motif chemokine receptor 5	Homo sapiens	242-246
11739641-6	2001	The terminal mannosyl moieties on Asn-169 of uroplakin Ia are responsible for FimH as well as concanavalin A binding.	Asparagine	34-37	uroplakin 1A	Mus musculus	45-57
11709091-3	2001	To further examine its role in viral infection, we introduced a conservative amino acid substitution (asparagine to glutamine) in the V3-proximal glycosylation motif (Asn-X-Ser/Thr) in the surface glycoprotein of a CXCR4-using virus (BRU), a CCR5-using virus (SF162), and a dual-tropic virus (89.6).	Asparagine	167-170	C-X-C motif chemokine receptor 4	Homo sapiens	215-220
11709091-3	2001	To further examine its role in viral infection, we introduced a conservative amino acid substitution (asparagine to glutamine) in the V3-proximal glycosylation motif (Asn-X-Ser/Thr) in the surface glycoprotein of a CXCR4-using virus (BRU), a CCR5-using virus (SF162), and a dual-tropic virus (89.6).	Asparagine	167-170	C-C motif chemokine receptor 5	Homo sapiens	242-246
11709091-7	2001	This effect was not dependent on the specific amino acid substitution used, because a threonine-toalanine mutation in the same motif in 89.6 Env yielded identical results as the asparagine-to-glutamine mutation.	Asparagine	178-188	endogenous retrovirus group K member 20	Homo sapiens	141-144
11791712-3	2001	To investigate the function of Spf1p, Asp487, the putative phosphorylation site of Spf1p, was replaced by Asn.	Asparagine	106-109	ion-transporting P-type ATPase SPF1	Saccharomyces cerevisiae S288C	31-36
11825324-2	2001	Extension of the C-terminal of the B-chain with two arginine residues and the substitution of glycine for asparagine at position A-21 increases the isoelectric point, resulting in precipitation of the insulin at the injection site and a protracted absorption.	Asparagine	106-116	insulin	Homo sapiens	201-208
11676606-4	2001	Human CD154 contains a single N-linked glycosylation site at asparagine 240.	Asparagine	61-71	CD40 ligand	Homo sapiens	6-11
11602718-4	2001	The critical determinant for this effect was an acidic amino acid at position 13 in the CCR5 N terminus, which is an asparagine in huCCR5 and an aspartic acid in rhCCR5.	Asparagine	117-127	C-C motif chemokine receptor 5	Homo sapiens	88-92
11676606-8	2001	Together, these results indicate that the presence of varied types of N-linked glycans on asparagine 240 of CD154 does not play a significant role in the CD40-CD154 interactions.	Asparagine	90-100	CD40 ligand	Homo sapiens	108-113
11601995-4	2001	Seven site-specific point mutants of MDP-1 were produced by modifying the catalytic aspartate, serine, and lysine residues to asparagine or glutamate, alanine, and arginine, respectively.	Asparagine	126-136	magnesium dependent phosphatase 1	Homo sapiens	37-42
11597769-2	2001	These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598.	Asparagine	64-74	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	41-44
11597769-2	2001	These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598.	Asparagine	64-74	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	138-141
11687971-4	2001	Substitution of the aspartic acid residue 231 by an asparagine residue in its catalytic site abrogated the cathepsin-D proteolytic activity but did not affect its expression level, processing or secretion.	Asparagine	52-62	cathepsin D	Mus musculus	107-118
11580295-1	2001	The oligosaccharyltransferase (OST) preferentially utilizes the fully assembled dolichol-linked oligosaccharide Glc(3)Man(9)GlcNAc(2)-PP-Dol as the donor for N-linked glycosylation of asparagine residues in N-X-T/S consensus sites in newly synthesized proteins.	Asparagine	184-194	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	4-29
11580295-1	2001	The oligosaccharyltransferase (OST) preferentially utilizes the fully assembled dolichol-linked oligosaccharide Glc(3)Man(9)GlcNAc(2)-PP-Dol as the donor for N-linked glycosylation of asparagine residues in N-X-T/S consensus sites in newly synthesized proteins.	Asparagine	184-194	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	31-34
11481329-5	2001	Overexpression of tagged HDGF proteins with point mutations in the putative bipartite nuclear localization sequence in the carboxyl terminus demonstrated that single Lys --&gt; Asn mutations randomized HDGF expression to both the nucleus and cytoplasm similar to the empty vector.	Asparagine	177-180	heparin binding growth factor	Homo sapiens	25-29
11481329-5	2001	Overexpression of tagged HDGF proteins with point mutations in the putative bipartite nuclear localization sequence in the carboxyl terminus demonstrated that single Lys --&gt; Asn mutations randomized HDGF expression to both the nucleus and cytoplasm similar to the empty vector.	Asparagine	177-180	heparin binding growth factor	Homo sapiens	202-206
11580253-10	2001	Consistent with this idea, Abeta peptides containing Asp-->Asn or His-->Gln substitutions showed altered fibrillogenesis kinetics.	Asparagine	59-62	amyloid beta precursor protein	Homo sapiens	27-32
11557028-5	2001	When expressed in Xenopus oocytes with human 4F2hc (h4F2hc), hLAT1 transports large neutral amino acids with high affinity (K(m)= approximately 15- approximately 50 microM) and L-glutamine and L-asparagine with low affinity (K(m)= approximately 1.5- approximately 2 mM).	Asparagine	193-205	solute carrier family 3 member 2	Homo sapiens	53-58
11712419-3	2001	These include a nonsense mutation (R179X), associated with exon skipping, missense mutations (G27E, P126R), and an insertion of AAC between codons 228 and 229, leading to an insertion of amino acid Asn.	Asparagine	198-201	glycine-N-acyltransferase	Homo sapiens	128-131
11557457-5	2001	Speculating that the multiple acidic residues of human LL-37 reduced its efficacy against staphylococci, we made a peptide (LL-37 pentamide) in which each aspartic acid of LL-37 was replaced by an asparagine and each glutamic acid was replaced by a glutamine.	Asparagine	197-207	cathelicidin antimicrobial peptide	Homo sapiens	55-60
11557028-5	2001	When expressed in Xenopus oocytes with human 4F2hc (h4F2hc), hLAT1 transports large neutral amino acids with high affinity (K(m)= approximately 15- approximately 50 microM) and L-glutamine and L-asparagine with low affinity (K(m)= approximately 1.5- approximately 2 mM).	Asparagine	193-205	solute carrier family 7 member 5	Homo sapiens	61-66
11418591-7	2001	We demonstrate that autopolysialylation depends on specific N-glycans attached to Asn(74) in ST8SiaIV and Asn(89) and Asn(219) in ST8SiaII.	Asparagine	82-85	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	93-101
11585801-4	2001	Lysine 149 of Xbra is conserved in all Brachyury homologues, while the corresponding amino acid in VegT and Eomesodermin is asparagine.	Asparagine	124-134	vegt protein S homeolog	Xenopus laevis	99-103
11562779-7	2001	The HLA DQB1*0501 peptide ligand sequence showed that proline gives an outstanding signal at position 2, Asn/Arg at P1, aliphatic/aromatic amino acids in the central portion, a hydrophobic cluster at P5 with a small contribution by small polar residues and another cluster of aromatic residues towards the C-terminus.	Asparagine	105-108	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
11567902-3	2001	Three active sites characteristic for cathepsin B were conserved in the deduced amino acid sequences of BmCtB cDNA at positions Cys-111, His-280 and Asn-300.	Asparagine	149-152	cathepsin B	Bombyx mori	38-49
11590221-7	2001	We suggest that macrophage-derived PAF-AH contains heterogeneous asparagine-conjugated sugar chain(s) involving sialic acid, which hinders its association with HDL but does not influence the secretion, catalytic activity, or resistance of PAF-AH to proteases.	Asparagine	65-75	phospholipase A2 group VII	Homo sapiens	35-41
11489391-1	2001	Gln117 t-PA is a mutant type of tissue-type plasminogen activator (mt-PA), which is generated by the removal of a high mannose oligosaccharide resulting from the mutation of amino acid #117, from asparagine (Asn) to glutamine (Gln).	Asparagine	196-206	plasminogen activator, tissue type	Rattus norvegicus	7-11
11489391-1	2001	Gln117 t-PA is a mutant type of tissue-type plasminogen activator (mt-PA), which is generated by the removal of a high mannose oligosaccharide resulting from the mutation of amino acid #117, from asparagine (Asn) to glutamine (Gln).	Asparagine	208-211	plasminogen activator, tissue type	Rattus norvegicus	7-11
11544325-0	2001	N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.	Asparagine	27-30	lymphocyte antigen 96	Homo sapiens	57-61
11544325-0	2001	N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.	Asparagine	27-30	toll like receptor 4	Homo sapiens	79-99
11544325-0	2001	N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.	Asparagine	39-42	lymphocyte antigen 96	Homo sapiens	57-61
11544325-0	2001	N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.	Asparagine	39-42	toll like receptor 4	Homo sapiens	79-99
11544325-4	2001	Mutation of either one of two potential glycosylation sites (Asn(26) and Asn(114)) of MD-2 resulted in the disappearance of the slowest mobility form, and only the fastest form was detected in hMD-2 carrying mutations at both Asn(26) and Asn(114).	Asparagine	61-64	lymphocyte antigen 96	Homo sapiens	86-90
11544325-4	2001	Mutation of either one of two potential glycosylation sites (Asn(26) and Asn(114)) of MD-2 resulted in the disappearance of the slowest mobility form, and only the fastest form was detected in hMD-2 carrying mutations at both Asn(26) and Asn(114).	Asparagine	73-76	lymphocyte antigen 96	Homo sapiens	86-90
11544325-4	2001	Mutation of either one of two potential glycosylation sites (Asn(26) and Asn(114)) of MD-2 resulted in the disappearance of the slowest mobility form, and only the fastest form was detected in hMD-2 carrying mutations at both Asn(26) and Asn(114).	Asparagine	73-76	lymphocyte antigen 96	Homo sapiens	86-90
11544325-4	2001	Mutation of either one of two potential glycosylation sites (Asn(26) and Asn(114)) of MD-2 resulted in the disappearance of the slowest mobility form, and only the fastest form was detected in hMD-2 carrying mutations at both Asn(26) and Asn(114).	Asparagine	73-76	lymphocyte antigen 96	Homo sapiens	86-90
11544325-7	2001	These observations demonstrate that hMD-2 undergoes N-linked glycosylation at Asn(26) and Asn(114), and that these glycosylations are crucial for TLR4-mediated signal transduction of LPS.	Asparagine	78-81	lymphocyte antigen 96	Homo sapiens	36-41
11544325-7	2001	These observations demonstrate that hMD-2 undergoes N-linked glycosylation at Asn(26) and Asn(114), and that these glycosylations are crucial for TLR4-mediated signal transduction of LPS.	Asparagine	78-81	interferon regulatory factor 6	Homo sapiens	183-186
11544325-7	2001	These observations demonstrate that hMD-2 undergoes N-linked glycosylation at Asn(26) and Asn(114), and that these glycosylations are crucial for TLR4-mediated signal transduction of LPS.	Asparagine	90-93	lymphocyte antigen 96	Homo sapiens	36-41
11544325-7	2001	These observations demonstrate that hMD-2 undergoes N-linked glycosylation at Asn(26) and Asn(114), and that these glycosylations are crucial for TLR4-mediated signal transduction of LPS.	Asparagine	90-93	interferon regulatory factor 6	Homo sapiens	183-186
11429416-0	2001	Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase.	Asparagine	60-63	lipase A, lysosomal acid type	Rattus norvegicus	76-96
11520040-1	2001	The serum iron transport protein human transferrin (hTf) is a glycoprotein (MW approximately 79.6 kDa) containing two Asn-linked sites of glycosylation.	Asparagine	118-121	transferrin	Homo sapiens	39-50
11429416-5	2001	The substitution Asn(506) --&gt; Ser(506), creating a potential phosphorylation site, uniformly increased activity with both PNPA and PNPC, was necessary but not sufficient for expression of cholesteryl esterase activity and conferred susceptibility to activation by cAMP-dependent protein kinase, a property of hncCEH.	Asparagine	17-20	lipase A, lysosomal acid type	Rattus norvegicus	191-211
11703833-3	2001	Analysis of the exon 2 sequence revealed that the DRB1*0314 contained the characteristic DR3 specific sequence motifs, except for codon 77 (AAC--&gt;ACC) where threonine is substituted for asparagine.	Asparagine	189-199	major histocompatibility complex, class II, DR beta 1	Homo sapiens	50-54
11485552-9	2001	The results demonstrate that there are several sites of metabolic adaptation in ASNase-treated leukaemia cells that serve to promote the replenishment of both glutamine and asparagine.	Asparagine	173-183	asparaginase and isoaspartyl peptidase 1	Homo sapiens	80-86
11390392-8	2001	Moreover, substitution of Asn-26 in IL-2 with Gln or Asp conserved the dimeric form and affected the carbohydrate recognition activities in correspondence with the cell proliferation activities, suggesting that Asn-26 in IL-2 is involved in the carbohydrate recognition site.	Asparagine	211-214	interleukin 2	Homo sapiens	36-40
11390392-8	2001	Moreover, substitution of Asn-26 in IL-2 with Gln or Asp conserved the dimeric form and affected the carbohydrate recognition activities in correspondence with the cell proliferation activities, suggesting that Asn-26 in IL-2 is involved in the carbohydrate recognition site.	Asparagine	211-214	interleukin 2	Homo sapiens	221-225
11390392-8	2001	Moreover, substitution of Asn-26 in IL-2 with Gln or Asp conserved the dimeric form and affected the carbohydrate recognition activities in correspondence with the cell proliferation activities, suggesting that Asn-26 in IL-2 is involved in the carbohydrate recognition site.	Asparagine	26-29	interleukin 2	Homo sapiens	36-40
11390392-8	2001	Moreover, substitution of Asn-26 in IL-2 with Gln or Asp conserved the dimeric form and affected the carbohydrate recognition activities in correspondence with the cell proliferation activities, suggesting that Asn-26 in IL-2 is involved in the carbohydrate recognition site.	Asparagine	26-29	interleukin 2	Homo sapiens	221-225
11356854-2	2001	A significant proportion of the alpha2,6-sialyltransferase of protein Asn-linked glycosylation (ST6Gal I) forms disulfide-bonded dimers that exhibit decreased activity, but retain the ability to bind asialoglycoprotein substrates.	Asparagine	70-73	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	96-104
11531804-6	2001	We also report a novel amino acid substitution mutation in codon 192 of KRT2E (asparagine to lysine) in the conserved 1A helix initiation peptide of the protein in the patient with IBS.	Asparagine	79-89	keratin 2	Homo sapiens	72-77
11384969-7	2001	Our studies further show that Phe(293) and Asn(294) in CaM kinase II play dual roles, because they likely destabilize the low affinity state of CaM complexed to unphosphorylated kinase but stabilize the trapped state of CaM bound to phosphorylated kinase.	Asparagine	43-46	calmodulin 1	Homo sapiens	55-58
11384969-7	2001	Our studies further show that Phe(293) and Asn(294) in CaM kinase II play dual roles, because they likely destabilize the low affinity state of CaM complexed to unphosphorylated kinase but stabilize the trapped state of CaM bound to phosphorylated kinase.	Asparagine	43-46	calmodulin 1	Homo sapiens	144-147
11384969-7	2001	Our studies further show that Phe(293) and Asn(294) in CaM kinase II play dual roles, because they likely destabilize the low affinity state of CaM complexed to unphosphorylated kinase but stabilize the trapped state of CaM bound to phosphorylated kinase.	Asparagine	43-46	calmodulin 1	Homo sapiens	144-147
11477614-13	2001	At position 66, asparagine in DRB1*03 and tyrosine in DRB1*04 are replaced by phenylalanine in DRB1*07.	Asparagine	16-26	major histocompatibility complex, class II, DR beta 1	Homo sapiens	30-34
11467936-4	2001	By contrast, Lec1A CHO mutants have weak GlcNAc-TI activity due to the reduced affinity of GlcNAc-TI for both the UDP-GlcNAc and Man(5)GlcNAc(2)Asn substrates.	Asparagine	144-147	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	41-50
11501752-1	2001	PURPOSE: To study the structural alterations of asparagine-linked sugar chains (N-glycans) on urine fibronectin (Fn) from bladder cancer (BCa) patients and its enzymatic mechanism.	Asparagine	48-58	fibronectin 1	Homo sapiens	100-111
11501752-1	2001	PURPOSE: To study the structural alterations of asparagine-linked sugar chains (N-glycans) on urine fibronectin (Fn) from bladder cancer (BCa) patients and its enzymatic mechanism.	Asparagine	48-58	fibronectin 1	Homo sapiens	113-115
11467936-4	2001	By contrast, Lec1A CHO mutants have weak GlcNAc-TI activity due to the reduced affinity of GlcNAc-TI for both the UDP-GlcNAc and Man(5)GlcNAc(2)Asn substrates.	Asparagine	144-147	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	91-100
11412044-0	2001	Diverse roles of conserved asparagine-linked glycan sites on tyrosinase family glycoproteins.	Asparagine	27-37	tyrosinase	Homo sapiens	61-71
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Asparagine	83-93	3'-nucleotidase	Homo sapiens	13-17
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Asparagine	83-93	neurotrophin 4	Homo sapiens	22-26
11428934-2	2001	The native structure of MOG presents a glycosylation site at position 31 (Asn(31)).	Asparagine	74-77	myelin oligodendrocyte glycoprotein	Homo sapiens	24-27
11415466-8	2001	These data document that ASNase resistance in ALL cells is a consequence of elevated AS expression and that although other drug-induced metabolic changes occur, they are secondary to the increased asparagine biosynthetic rate.	Asparagine	197-207	asparaginase and isoaspartyl peptidase 1	Homo sapiens	25-31
11423399-2	2001	We substituted a cysteine for the asparagine present at that position in both NR1 and NR2 N-methyl-D-aspartate (NMDA) receptor subunits.	Asparagine	34-44	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	78-81
11412044-3	2001	Potential N-linked glycosylation sites on the lumenal domains of mouse gp75/TRP-1/Tyrp1 and human tyrosinase were eliminated by site-directed mutagenesis (Asn to Gln substitutions).	Asparagine	155-158	tyrosinase-related protein 1	Mus musculus	76-81
11412044-3	2001	Potential N-linked glycosylation sites on the lumenal domains of mouse gp75/TRP-1/Tyrp1 and human tyrosinase were eliminated by site-directed mutagenesis (Asn to Gln substitutions).	Asparagine	155-158	tyrosinase-related protein 1	Mus musculus	82-87
11412044-3	2001	Potential N-linked glycosylation sites on the lumenal domains of mouse gp75/TRP-1/Tyrp1 and human tyrosinase were eliminated by site-directed mutagenesis (Asn to Gln substitutions).	Asparagine	155-158	tyrosinase	Homo sapiens	98-108
11390601-1	2001	The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) is extensively glycosylated, containing approximately 23 asparagine (N)-linked glycosylation sites on its gp120 subunit.	Asparagine	130-140	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	179-184
11408611-4	2001	We found that the antagonistic action of AMD3100 against CXCR4--as assessed by the inhibitory effects of the compound on stromal cell-derived factor (SDF-1) binding to its receptor and on SDF-1-induced intracellular calcium signaling, and by displacement of the CXCR4-specific antibody, clone 12G5--was greatly reduced by substitution of Asp(171) and/or Asp(262) by neutral asparagine residue(s).	Asparagine	374-384	C-X-C motif chemokine receptor 4	Homo sapiens	57-62
11320079-7	2001	Site-directed mutagenesis experiments showed that replacement of the histidine with alanine, asparagine, aspartate, glutamate, glutamine, or arginine in N(t)-FDH resulted in expression of insoluble proteins.	Asparagine	93-103	aldehyde dehydrogenase 1 family member L1	Homo sapiens	153-161
11274162-3	2001	One protein, AVT1, is required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine, and leucine.	Asparagine	115-125	Avt1p	Saccharomyces cerevisiae S288C	13-17
11412103-2	2001	Both tails were largely flexible and unstructured, although, in the beta3 tail, residues Arg(724)-Ala(735) have a propensity to form a helical structure and residues Asn(744)-Tyr(747) (NPLY) have a propensity to adopt reverse-turn conformations.	Asparagine	166-169	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	68-73
11294842-4	2001	Here we have used exoglycosidase digestion and mass spectrometry to sequence the Asn (N)-linked and Ser/Thr (O)-linked oligosaccharides of human apo(a).	Asparagine	81-84	lipoprotein(a)	Homo sapiens	145-151
11403943-3	2001	The LAT2 specific amino acid, [(14)C]-L-Asn, was perfused alone or with excess concentration of various amino acids.	Asparagine	39-43	linker for activation of T cells family, member 2	Rattus norvegicus	4-8
11312274-0	2001	A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.	Asparagine	12-15	thyroid stimulating hormone receptor	Homo sapiens	86-106
11312274-2	2001	Here, we identified a molecular interaction between Asp(633) in transmembrane helix 6 (TM6) and Asn(674) in TM7 of the TSHr that is crucial to maintain the inactive state through conformational constraint of the Asn.	Asparagine	96-99	thyroid stimulating hormone receptor	Homo sapiens	119-123
11312274-2	2001	Here, we identified a molecular interaction between Asp(633) in transmembrane helix 6 (TM6) and Asn(674) in TM7 of the TSHr that is crucial to maintain the inactive state through conformational constraint of the Asn.	Asparagine	212-215	thyroid stimulating hormone receptor	Homo sapiens	119-123
11312274-8	2001	In the TSHr, the conformation of this Asn residue of TM7 would be constrained, in the inactive state, by its Asp partner in TM6.	Asparagine	38-41	thyroid stimulating hormone receptor	Homo sapiens	7-11
11304524-5	2001	Remarkably, the guanido group of arginine at position -1 of the CFTR peptide forms two salt bridges and two hydrogen bonds with PDZ1 residues Glu(43) and Asn(22), respectively, providing the structural basis for the contribution of the penultimate amino acid of the peptide ligand to the affinity of the interaction.	Asparagine	154-157	CF transmembrane conductance regulator	Homo sapiens	64-68
11274151-4	2001	Incubation of the cells at 15 degrees C revealed that ACE(NQ) was cleaved in the endoplasmic reticulum, and mass spectrometric analysis of the secreted form of the protein indicated that it had been cleaved at the Asn(635)-Ser(636) bond, three residues N-terminal to the normal secretase cleavage site at Arg(638)-Ser(639).	Asparagine	214-217	angiotensin I converting enzyme	Homo sapiens	54-57
11418116-1	2001	Aspartylglycosaminuria (AGU), a severe lysosomal storage disease, is caused by the deficiency of the lysosomal enzyme, glycosylasparaginase (GA), and accumulation of aspartylglucosamine (GlcNAc-Asn) in tissues.	Asparagine	194-197	aspartylglucosaminidase	Homo sapiens	141-143
11418116-2	2001	Here we show that human leukocyte glycosylasparaginase can correct the metabolic defect in Epstein-Barr virus (EBV)-transformed AGU lymphocytes rapidly and effectively by mannose-6-phosphate receptor-mediated endocytosis or by contact-mediated cell-to-cell transfer from normal EBV-transformed lymphocytes, and that 2-7% of normal activity is sufficient to correct the GlcNAc-Asn metabolism in the cells.	Asparagine	376-379	aspartylglucosaminidase	Homo sapiens	34-54
11459425-6	2001	The B4311 Asn allele was associated with a higher apoB level than the Ser group (p &lt; 0.05) in normal controls.	Asparagine	10-13	apolipoprotein B	Homo sapiens	50-54
11378370-2	2001	Fibronectin contains the active sequence Arg-Gly-Asp (RGD), along with its synergic site Pro-His-Ser-Arg-Asn (PHSRN).	Asparagine	105-108	fibronectin 1	Homo sapiens	0-11
11375896-7	2001	In addition, we studied an A--&gt;G polymorphism in codon 312 of exon 10, which results in an Asp--&gt;Asn substitution in a conserved region of XPD.	Asparagine	103-106	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	145-148
11459425-7	2001	In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) &gt; 200 mg/dL and apoB concentration &gt; 85 mg/dL than in the group with a TC &lt; 200 mg/dL and apoB &lt; 85 mg/dL (p = 0.03 for TC comparison).	Asparagine	39-42	apolipoprotein B	Homo sapiens	136-140
11459425-7	2001	In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) &gt; 200 mg/dL and apoB concentration &gt; 85 mg/dL than in the group with a TC &lt; 200 mg/dL and apoB &lt; 85 mg/dL (p = 0.03 for TC comparison).	Asparagine	39-42	apolipoprotein B	Homo sapiens	216-220
11459425-7	2001	In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) &gt; 200 mg/dL and apoB concentration &gt; 85 mg/dL than in the group with a TC &lt; 200 mg/dL and apoB &lt; 85 mg/dL (p = 0.03 for TC comparison).	Asparagine	43-46	apolipoprotein B	Homo sapiens	136-140
11459425-7	2001	In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) &gt; 200 mg/dL and apoB concentration &gt; 85 mg/dL than in the group with a TC &lt; 200 mg/dL and apoB &lt; 85 mg/dL (p = 0.03 for TC comparison).	Asparagine	43-46	apolipoprotein B	Homo sapiens	216-220
11389975-5	2001	There are three putative Asn-linked glycosylation sites in the extracellular, amino terminal domain of CRLR at positions 66, 118 and 123.	Asparagine	25-28	calcitonin receptor like receptor	Homo sapiens	103-107
11279129-6	2001	Exchange of His-90 of AtHAL3a for Asn led to complete inactivation of the enzyme.	Asparagine	34-37	HAL3-like protein A	Arabidopsis thaliana	22-29
11389975-8	2001	FACS analysis of cells expressing FLAG-tagged CRLRs showed that disrupting Asn-linked glycosylation severely affected the transport of the CRLR protein to the cell surface on N66/118/123Q mutant, and slightly reduced the level of the cell surface expression of N123Q mutant compared with wild-type CRLR.	Asparagine	75-78	calcitonin receptor like receptor	Homo sapiens	46-50
11389975-8	2001	FACS analysis of cells expressing FLAG-tagged CRLRs showed that disrupting Asn-linked glycosylation severely affected the transport of the CRLR protein to the cell surface on N66/118/123Q mutant, and slightly reduced the level of the cell surface expression of N123Q mutant compared with wild-type CRLR.	Asparagine	75-78	calcitonin receptor like receptor	Homo sapiens	139-143
11388408-8	2001	The observed sequence of the N-terminal amino acids, Glu-Glu-Gln-Asn-Lys, of the purified CSF-neurosin was identical to the sequence of N-terminal of the pro-enzyme form, which is presumed to have no enzyme activity.	Asparagine	65-68	colony stimulating factor 2	Homo sapiens	90-102
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	100-103	receptor activity modifying protein 1	Homo sapiens	20-25
11278492-7	2001	Site-directed mutagenesis of the asparagine residues at amino acid positions 153, 172, 223, and 354 demonstrate that the protease activity of Asp-2 is dependent on its glycosylation.	Asparagine	33-43	beta-secretase 1	Homo sapiens	142-147
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	100-103	calcitonin receptor like receptor	Homo sapiens	72-77
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	109-112	receptor activity modifying protein 1	Homo sapiens	20-25
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	109-112	calcitonin receptor like receptor	Homo sapiens	72-77
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	109-112	receptor activity modifying protein 1	Homo sapiens	20-25
11331002-2	2001	In mammalian cells, RAMP1 is required for mature N-glycosylation of the hCRLR predicted to occur at Asn(60), Asn(112), and/or Asn(117) in the amino-terminal extracellular domain.	Asparagine	109-112	calcitonin receptor like receptor	Homo sapiens	72-77
11331002-5	2001	In contrast, the hCRLR Asn(60,112) to Thr double mutant exhibited defective RAMP1-dependent N-glycosylation, and impaired cell surface expression and CGRP receptor function.	Asparagine	23-26	calcitonin receptor like receptor	Homo sapiens	17-22
11331002-5	2001	In contrast, the hCRLR Asn(60,112) to Thr double mutant exhibited defective RAMP1-dependent N-glycosylation, and impaired cell surface expression and CGRP receptor function.	Asparagine	23-26	receptor activity modifying protein 1	Homo sapiens	76-81
11331002-5	2001	In contrast, the hCRLR Asn(60,112) to Thr double mutant exhibited defective RAMP1-dependent N-glycosylation, and impaired cell surface expression and CGRP receptor function.	Asparagine	23-26	calcitonin related polypeptide alpha	Homo sapiens	150-154
11323742-6	2001	This reciprocal regulation of GLN2 and ASN1 genes by light is reflected at the level of transcription and at the level of glutamine and asparagine biosynthesis.	Asparagine	136-146	glutamine synthetase 2	Arabidopsis thaliana	30-34
11323742-6	2001	This reciprocal regulation of GLN2 and ASN1 genes by light is reflected at the level of transcription and at the level of glutamine and asparagine biosynthesis.	Asparagine	136-146	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	39-43
11344238-3	2001	The N363S polymorphism of the GR results in an asparagine to serine amino acid substitution in a modulatory region of the receptor.	Asparagine	47-57	nuclear receptor subfamily 3 group C member 1	Homo sapiens	30-32
11336800-3	2001	We found that substitution of histidine for the native asparagine at position 10 of PTH(1-14) provided a peptide that was approx.	Asparagine	55-65	parathyroid hormone	Rattus norvegicus	84-87
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Asparagine	301-304	thimet oligopeptidase 1	Homo sapiens	242-245
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Asparagine	301-304	neurolysin	Homo sapiens	290-300
11287119-4	2001	In this report, we show that the C-terminal deletion and two point mutations (Asp--&gt;Gly at residue 91 and Asp--&gt;Asn at residue 437) in v-Rel make it resistant to cleavage by the cell-death protease caspase-3.	Asparagine	118-121	caspase 3	Gallus gallus	204-213
11361134-7	2001	Therefore mutant proteins in which the N-glycosylation sites were eliminated (Asn --&gt; Gln in mouse MDR3 Pgp, Asn --&gt; Gln or Ala in human MDR1 Pgp) were expressed in P. pastoris and purified to homogeneity.	Asparagine	78-81	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	102-106
11300774-9	2001	We conclude that the residues corresponding to eNTPDase-3 glutamate 182 in ACR3 and serine 224 in ACR4 are essential for the enzymatic activity of eNTPDases in general, and that arginine 67, arginine 146, asparagine 191, and glutamine 226 are important for determining substrate specificity for human ecto-nucleoside triphosphate diphosphohydrolase 3.	Asparagine	205-215	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	47-57
11361134-7	2001	Therefore mutant proteins in which the N-glycosylation sites were eliminated (Asn --&gt; Gln in mouse MDR3 Pgp, Asn --&gt; Gln or Ala in human MDR1 Pgp) were expressed in P. pastoris and purified to homogeneity.	Asparagine	78-81	phosphoglycolate phosphatase	Mus musculus	107-110
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Asparagine	269-272	complement C1q A chain	Homo sapiens	153-156
11256970-0	2001	The efficiency of N-linked glycosylation of bovine DNase I depends on the Asn-Xaa-Ser/Thr sequence and the tissue of origin.	Asparagine	74-77	deoxyribonuclease 1	Bos taurus	51-58
11256970-1	2001	Bovine DNase I contains two potential N-linked glycosylation sites with the sequences Asn(18)-Ala-Thr and Asn(106)-Asp-Ser.	Asparagine	86-89	deoxyribonuclease 1	Bos taurus	7-14
11256970-1	2001	Bovine DNase I contains two potential N-linked glycosylation sites with the sequences Asn(18)-Ala-Thr and Asn(106)-Asp-Ser.	Asparagine	106-109	deoxyribonuclease 1	Bos taurus	7-14
11256970-2	2001	A previous report established that pancreatic DNase I has only one sugar chain at Asn(18) [Liao, Salnikow, Moore and Stein (1973) J. Biol.	Asparagine	82-85	deoxyribonuclease 1	Bos taurus	46-53
11256970-5	2001	We found, however, that bovine DNase I expressed in COS-1 cells was glycosylated about 70% at Asn(106) in addition to being completely glycosylated at Asn(18).	Asparagine	94-97	deoxyribonuclease 1	Bos taurus	31-38
11256970-5	2001	We found, however, that bovine DNase I expressed in COS-1 cells was glycosylated about 70% at Asn(106) in addition to being completely glycosylated at Asn(18).	Asparagine	151-154	deoxyribonuclease 1	Bos taurus	31-38
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Asparagine	103-106	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Asparagine	109-112	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Asparagine	109-112	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11287151-0	2001	Characterization of the active-site residues asparagine 167 and lysine 161 of the IMP-1 metallo beta-lactamase.	Asparagine	45-55	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	82-87
11287151-1	2001	The roles of lysine at position 161 and asparagine at position 167 in IMP-1 metallo beta-lactamase were studied by site-directed mutagenesis.	Asparagine	40-50	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	70-75
11308323-1	2001	Post-translational glycosylation of bovine beta-casein (L70S/P71S) that results in Asn(68)-linked glycan on the protein was obtained in up to 30% of total beta-casein expressed in the methylotrophic yeast Pichia pastoris.	Asparagine	83-86	casein beta	Bos taurus	43-54
11333309-5	2001	A remarkable feature of pea SCR protein was the presence of asparagine stretches at the N-terminal transcriptional activation domain, which was distinct from the occurrence of glutamine or alanine stretches in the Arabidopsis or maize SCR.	Asparagine	60-70	GRAS family transcription factor	Arabidopsis thaliana	28-31
11401481-1	2001	In the first step of asparagine-linked oligosaccharide chain maturation, terminal glucose residues are removed from the high mannose oligosaccharide core by glucosidases I and II.	Asparagine	21-31	mannosyl-oligosaccharide glucosidase	Homo sapiens	157-178
11258943-4	2001	The amidolytic activity of FVIIa mutants with Ser, Thr, and Asn in position 306 was stimulated 9-, 12-, and 7-fold, respectively, by soluble TF as compared to 22-fold for wild-type FVIIa.	Asparagine	60-63	coagulation factor III, tissue factor	Homo sapiens	141-143
11308323-1	2001	Post-translational glycosylation of bovine beta-casein (L70S/P71S) that results in Asn(68)-linked glycan on the protein was obtained in up to 30% of total beta-casein expressed in the methylotrophic yeast Pichia pastoris.	Asparagine	83-86	casein beta	Bos taurus	155-166
11241348-7	2001	We have found that when glutamines 12 or 58 are mutated to asparagines enhanced degradation of aldolase B proceeded normally.	Asparagine	59-70	aldolase, fructose-bisphosphate B	Rattus norvegicus	95-105
11238869-4	2001	Here we show that elimination of a single glycosylation site at asparagine 197 in the V1/V2 stem is sufficient for CD4-independent gp120 binding to CCR5 and for HIV-1 entry into CD4-negative cells expressing CCR5.	Asparagine	64-74	CD4 molecule	Homo sapiens	115-118
11238869-4	2001	Here we show that elimination of a single glycosylation site at asparagine 197 in the V1/V2 stem is sufficient for CD4-independent gp120 binding to CCR5 and for HIV-1 entry into CD4-negative cells expressing CCR5.	Asparagine	64-74	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	131-136
11238869-4	2001	Here we show that elimination of a single glycosylation site at asparagine 197 in the V1/V2 stem is sufficient for CD4-independent gp120 binding to CCR5 and for HIV-1 entry into CD4-negative cells expressing CCR5.	Asparagine	64-74	C-C motif chemokine receptor 5	Homo sapiens	148-152
11238869-4	2001	Here we show that elimination of a single glycosylation site at asparagine 197 in the V1/V2 stem is sufficient for CD4-independent gp120 binding to CCR5 and for HIV-1 entry into CD4-negative cells expressing CCR5.	Asparagine	64-74	CD4 molecule	Homo sapiens	178-181
11238869-4	2001	Here we show that elimination of a single glycosylation site at asparagine 197 in the V1/V2 stem is sufficient for CD4-independent gp120 binding to CCR5 and for HIV-1 entry into CD4-negative cells expressing CCR5.	Asparagine	64-74	C-C motif chemokine receptor 5	Homo sapiens	208-212
11134011-6	2001	Constitutive B1R activity was further increased by alanine mutation of Asn(121) in the third transmembrane domain of the receptor (B1A(121)).	Asparagine	71-74	bradykinin receptor B1	Homo sapiens	13-16
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Asparagine	269-272	complement C1q A chain	Homo sapiens	219-222
11255023-1	2001	Queuosine (Q) is a 7-deazaguanosine found in the first position of the anticodon of tRNAs that recognize NAU and NAC codons (Tyr, Asn, Asp and His).	Asparagine	130-133	X-linked Kx blood group	Homo sapiens	113-116
11076950-3	2001	Man(5)GlcNAc(2)Asn added to CTLL-2 cell cultures inhibited not only phosphorylation of tyrosine kinases but also IL-2-dependent cell proliferation.	Asparagine	15-18	interleukin 2	Mus musculus	113-117
11248110-7	2001	Mutagenesis data indicate that the N site, a key asparagine on the M2 transmembrane segment of the NR1 subunit, is the main determinant of the blocker action.	Asparagine	49-59	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	99-102
11222741-9	2001	The two subtypes also differ in a single amino acid residue in the hormone-binding pocket, Asn (TRbeta) for Ser (TRalpha).	Asparagine	91-94	T cell receptor alpha locus	Homo sapiens	113-120
11243884-5	2001	When expressed in mammalian cells, the cloned human SN2 mediates Na(+)-coupled transport of system N-specific amino acid substrates (glutamine, asparagine, and histidine).	Asparagine	144-154	solute carrier family 38 member 5	Homo sapiens	52-55
11243846-13	2001	The data suggest that Asn-linked carbohydrate groups account for much of the p77 mass of the MC5-R.	Asparagine	22-25	melanocortin 5 receptor	Rattus norvegicus	93-98
11241847-5	2001	Sequencing of the entire coding region of the EPO gene disclosed a novel mutation, a 2060 G-A transition (g. 2060G&gt;A) causing an amino acid change from aspartic acid to asparagine (D648N).	Asparagine	172-182	eosinophil peroxidase	Homo sapiens	46-49
11222741-9	2001	The two subtypes also differ in a single amino acid residue in the hormone-binding pocket, Asn (TRbeta) for Ser (TRalpha).	Asparagine	91-94	T cell receptor beta locus	Homo sapiens	96-102
11226225-2	2001	Previous studies have demonstrated that asparagine residues can drive transmembrane helix association through interhelical hydrogen bonding [Choma, C., Gratkowski, H., Lear, J. D. &amp; DeGrado, W. F. (2000) Nat.	Asparagine	40-50	bromodomain containing 2	Homo sapiens	208-211
11354825-2	2001	Additionally, the Asn allele of the ADA Asp8Asn polymorphism has been associated with reduced enzymatic activity.	Asparagine	18-21	adenosine deaminase	Homo sapiens	36-39
11160345-5	2001	Sequencing of TIMP-1"s alpha-chymase-mediated cleavage products reveals hydrolysis at Phe(12)-Cys(13) and Phe(23)-Val(24) in loop 1 and Phe(101)-Val(102) and Trp(105)-Asn(106) in loop 3 of the NH(2)-terminal domain.	Asparagine	167-170	TIMP metallopeptidase inhibitor 1	Homo sapiens	14-20
11157796-6	2001	Strikingly, a disease-causing Ile--&gt;Asn substitution at amino acid position 304 (I304N) renders FMRP incapable of interfering with translation in both test systems.	Asparagine	39-42	fragile X messenger ribonucleoprotein 1	Homo sapiens	99-103
11160345-5	2001	Sequencing of TIMP-1"s alpha-chymase-mediated cleavage products reveals hydrolysis at Phe(12)-Cys(13) and Phe(23)-Val(24) in loop 1 and Phe(101)-Val(102) and Trp(105)-Asn(106) in loop 3 of the NH(2)-terminal domain.	Asparagine	167-170	chymase 1	Homo sapiens	23-36
11368335-2	2001	Mouse 8-LOX and its homologues (e.g., human 15-LOX-2) are unique in having a serine in place of the usual Asn or His in this fifth position.	Asparagine	106-109	arachidonate 8-lipoxygenase	Mus musculus	6-11
11368335-2	2001	Mouse 8-LOX and its homologues (e.g., human 15-LOX-2) are unique in having a serine in place of the usual Asn or His in this fifth position.	Asparagine	106-109	arachidonate 15-lipoxygenase type B	Homo sapiens	44-52
11050076-4	2001	It covalently labeled the CCK receptor either within the amino terminus (between Asn(10) and Lys(37)) or within the third extracellular loop (Glu(345)), as demonstrated by proteolytic peptide mapping, deglycosylation, micropurification, and Edman degradation sequencing.	Asparagine	81-84	cholecystokinin	Homo sapiens	26-29
11248282-6	2001	A second mutation characterised by a G(1344)--&gt;C transversion in exon VIII was detected in the proband resulting in a Lys(408)--&gt;Asn substitution.	Asparagine	135-138	cytochrome c oxidase subunit 8A	Homo sapiens	73-77
11076939-4	2001	The second version, GluR1-M1, consisted of the first N-terminal extracellular domain (Ala(1)-Glu(520)) bridged by a synthetic linker to a second segment containing the second extracellular domain, the third transmembrane domain, and the intracellular C-terminal domain (Asn(615)-Leu(889)).	Asparagine	270-273	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	20-25
11297671-3	2001	In an attempt to decrease the aggregation of E.coli-derived EPO, the three asparagine residues at positions 24, 38 and 83 were mutated to lysine residues.	Asparagine	75-85	erythropoietin	Homo sapiens	60-63
11251288-12	2001	CONCLUSIONS: Erythropoietin expressed in E. coli bearing specific Asn--&gt;Cys mutations at natural glycosylation sites can be glycosylated using beta-N-glycosyl iodoacetamides even in the presence of two disulfide bonds.	Asparagine	66-69	erythropoietin	Homo sapiens	13-27
11563698-3	2001	The B haplotype encodes two alpha-globin chains, Ialpha2 and IIalpha4, which differ at positions 10 and 11: Ialpha2 has 10 I1e, 11 Gln, 64 Asn; IIalpha4 has 10 Val, 11 Lys, 64 Asn.	Asparagine	139-142	hemoglobin subunit alpha-4-like	Bubalus bubalis	61-69
11563698-3	2001	The B haplotype encodes two alpha-globin chains, Ialpha2 and IIalpha4, which differ at positions 10 and 11: Ialpha2 has 10 I1e, 11 Gln, 64 Asn; IIalpha4 has 10 Val, 11 Lys, 64 Asn.	Asparagine	176-179	hemoglobin subunit alpha-4-like	Bubalus bubalis	61-69
11220749-5	2001	The delN296 mutation lies in the sequence corresponding to the second tubulin-binding repeat of tau protein and affects one asparagine residue absolutely conserved in other species.	Asparagine	124-134	microtubule associated protein tau	Homo sapiens	96-99
11315632-6	2001	Adaptation to CD46 receptor usage was coupled to substitution of amino acid 481 of the MV H protein from asparagine to tyrosine but not to CD46 downregulation.	Asparagine	105-115	CD46 molecule	Homo sapiens	14-18
11060302-5	2001	Interestingly, not only aspartic acid but also asparagine were identified as products of NIT4-catalyzed Ala(CN) hydrolysis.	Asparagine	47-57	nitrilase 4	Arabidopsis thaliana	89-93
11060302-9	2001	The NIT4 homologs of N. tabacum were found to catalyze the same reactions and protein extracts of A. thaliana, N. tabacum and Lupinus angustifolius also converted Ala(CN) to Asp and Asn in vitro.	Asparagine	182-185	nitrilase 4	Arabidopsis thaliana	4-8
11452978-1	2001	Extracellular asparagine has previously been shown to markedly stimulate both ornithine decarboxylase and System N-mediated glutamine transport activities in hepatocytes by a transport-dependent mechanism.	Asparagine	14-24	ornithine decarboxylase 1	Rattus norvegicus	78-101
11342099-3	2001	The cDNAs encode three different putative CCK-8 peptides containing Asn, Leu or Thr, in position 6 (counting from the C-terminus).	Asparagine	68-71	cholecystokinin	Homo sapiens	42-45
11221967-2	2001	The goal of the clinical study was to determine the toxicity and optimum biologic dose of PEG-L-asparaginase based on depletion of serum L-asparagine in patients with advanced solid tumors.	Asparagine	137-149	asparaginase and isoaspartyl peptidase 1	Homo sapiens	94-108
11221967-13	2001	CONCLUSIONS: We conclude that PEG-L-asparaginase is generally well tolerated in patients with advanced solid tumors, and a dosage of 2,000 IU/m2 by intramuscular injection every 2 weeks results in significant depletion of serum L-asparagine.	Asparagine	228-240	asparaginase and isoaspartyl peptidase 1	Homo sapiens	34-48
12040407-1	2001	To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys.	Asparagine	176-179	interleukin 18	Homo sapiens	74-79
11287679-1	2001	The structure and biological activities of two disulphide isomers of a C-region deletion mutant of insulin-like growth factor-I (IGF-I) which has an Asn--Gly link engineered at the junction of the A- and B-regions were studied before and after chemical cleavage.	Asparagine	149-152	insulin like growth factor 1	Homo sapiens	99-127
11287679-1	2001	The structure and biological activities of two disulphide isomers of a C-region deletion mutant of insulin-like growth factor-I (IGF-I) which has an Asn--Gly link engineered at the junction of the A- and B-regions were studied before and after chemical cleavage.	Asparagine	149-152	insulin like growth factor 1	Homo sapiens	129-134
11280065-6	2001	Interestingly, Gly-437 in dhps along with Arg-59/Asn-108 in dhfr were associated with RI, RII and RIII resistance whereas Glu-540 was highly associated with only RII and RIII Fansidar resistance.	Asparagine	49-52	dihydrofolate reductase	Homo sapiens	60-64
12035060-7	2001	Mutation of Asn (beta2) to Gln caused the K ( m ) value being increased by 5-fold, and k ( cat ) decreased by 10-fold.	Asparagine	12-15	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-22
11119727-2	2000	Three putative N-glycosylation sites Asn(60), Asn(112) and Asn(117) are present in the amino-terminal extracellular domain of the hCRLR.	Asparagine	37-40	calcitonin receptor like receptor	Homo sapiens	130-135
11204595-3	2001	r-VIII SQ retains six potential glycosylation sites for N-linked oligosaccharides at asparagine residues 41, 239, 582, 1685, 1810 and 2118.	Asparagine	85-95	cytochrome c oxidase subunit 8A	Homo sapiens	2-6
10995773-3	2000	We describe the expression, purification, and biochemical analysis of the Asp(684) --&gt; Asn mutant, and provide evidence that Asp(684) in the plasma membrane H(+)-ATPase is required for any coupling between ATP hydrolysis, enzyme conformational changes, and H(+)-transport.	Asparagine	90-93	plasma membrane H+-ATPase	Arabidopsis thaliana	144-171
11119727-2	2000	Three putative N-glycosylation sites Asn(60), Asn(112) and Asn(117) are present in the amino-terminal extracellular domain of the hCRLR.	Asparagine	46-49	calcitonin receptor like receptor	Homo sapiens	130-135
11119727-2	2000	Three putative N-glycosylation sites Asn(60), Asn(112) and Asn(117) are present in the amino-terminal extracellular domain of the hCRLR.	Asparagine	46-49	calcitonin receptor like receptor	Homo sapiens	130-135
11119727-4	2000	Similarly, the double mutant myc-hCRLR(N60,112T) exhibited minimal N-glycosidase F sensitive glycosylation, presumably at the third Asn(117), and the cell surface expression and specific radioligand binding were impaired.	Asparagine	132-135	calcitonin receptor like receptor	Homo sapiens	33-38
11093789-4	2000	Transient expression in CHOP cells demonstrated that changing Asn(24) or Asn(191) inhibited GRP-R cell surface expression, whereas elimination of Asn(5) and Asn(20) had no effect.	Asparagine	62-65	gastrin releasing peptide receptor	Mus musculus	92-97
11159917-4	2000	Gel filtration analysis of the pronase-resistant gC-1 O-glycan clusters from a glycoprotein mutant, lacking a site for N-linked glycosylation at Asn 73 in the vicinity of the O-glycosylation signal, suggested that one function of this N-linked glycan was to modulate the access for GalNAc transferases to one particular O-glycosylation peptide signal (aa 80-104).	Asparagine	145-148	solute carrier family 25 member 22	Homo sapiens	49-53
11082042-3	2000	The deduced amino acid sequence of porcine thyroid cathepsin K predicted a 37 kDa preproenzyme, with the active site residues Cys-140, His-277 and Asn-297, and one potential N-glycosylation site.	Asparagine	147-150	cathepsin K	Homo sapiens	51-62
11082044-3	2000	PACSIN 3 differs from the other family members in having a short proline-rich region and lacking asparagine-proline-phenylalanine motifs.	Asparagine	97-107	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	0-8
10948191-0	2000	An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.	Asparagine	3-6	adrenoceptor alpha 2A	Homo sapiens	72-100
11163209-5	2000	ATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively.	Asparagine	38-48	activating transcription factor 6	Homo sapiens	0-4
11163209-5	2000	ATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively.	Asparagine	38-48	membrane bound transcription factor peptidase, site 1	Homo sapiens	88-91
11093789-4	2000	Transient expression in CHOP cells demonstrated that changing Asn(24) or Asn(191) inhibited GRP-R cell surface expression, whereas elimination of Asn(5) and Asn(20) had no effect.	Asparagine	73-76	gastrin releasing peptide receptor	Mus musculus	92-97
11093789-4	2000	Transient expression in CHOP cells demonstrated that changing Asn(24) or Asn(191) inhibited GRP-R cell surface expression, whereas elimination of Asn(5) and Asn(20) had no effect.	Asparagine	73-76	gastrin releasing peptide receptor	Mus musculus	92-97
11093789-4	2000	Transient expression in CHOP cells demonstrated that changing Asn(24) or Asn(191) inhibited GRP-R cell surface expression, whereas elimination of Asn(5) and Asn(20) had no effect.	Asparagine	73-76	gastrin releasing peptide receptor	Mus musculus	92-97
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Asparagine	32-35	mitogen-activated protein kinase 14	Homo sapiens	57-60
11191884-10	2000	Since an asparagine is conserved at the equivalent position to N61 of FMO3 in mammalian, yeast and Caenorhabditis elegans FMOs, the characterization of the naturally occurring N61S (A to G) mutation may have identified this asparagine as playing a critical role specifically in FMO-catalysed N-oxidation.	Asparagine	224-234	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	70-74
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Asparagine	32-35	mitogen-activated protein kinase 1	Homo sapiens	79-83
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Asparagine	32-35	dual specificity phosphatase 1	Homo sapiens	185-190
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Asparagine	143-146	thromboxane A synthase 1	Homo sapiens	13-17
11206080-3	2000	We have studied the oxidative folding of a RNase A derivative containing at position 67 the substitution Asn --&gt; isoAsp where the local structure of the loop 65-72 has been modified keeping intact the C65-C72 disulfide bond.	Asparagine	105-108	ribonuclease A family member 1, pancreatic	Homo sapiens	43-50
10944517-7	2000	This difference in stop transfer activity was due to two residues that altered both the length and hydrophobicity of TM2 (Asn(49) and Lys(51) in AQP1 versus Met(48) and Leu(50) in AQP4).	Asparagine	122-125	aquaporin 1 (Colton blood group)	Homo sapiens	145-149
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Asparagine	143-146	thromboxane A synthase 1	Homo sapiens	82-86
10993946-3	2000	By mutating asparagines to glutamines at the consensus sites, we obtained expression of unglycosylated, epitope-tagged MHM2PrP(N180Q,N196Q), which was converted into PrP(Sc) in ScN2a cells.	Asparagine	12-23	prion protein	Mus musculus	166-173
11443278-5	2000	In contrast to OST48, ribophorin I and II contain, respectively, three or two potential N-glycosylation sites of the Asn-Xaa-Thr/Ser type; only one is found to function as the acceptor site in each protein.	Asparagine	117-120	ribophorin I	Sus scrofa	22-41
11069038-2	2000	Cytosine replaces thymidine; the corresponding triplets are AAT (T allele) and AAC (C allele), respectively, both coding for asparagine.	Asparagine	125-135	glycine-N-acyltransferase	Homo sapiens	79-82
11068879-0	2000	Structural analysis of the asparagine-linked glycan units of the ZP2 and ZP3 glycoproteins from mouse zona pellucida.	Asparagine	27-37	zona pellucida glycoprotein 2	Mus musculus	65-68
11068879-0	2000	Structural analysis of the asparagine-linked glycan units of the ZP2 and ZP3 glycoproteins from mouse zona pellucida.	Asparagine	27-37	zona pellucida glycoprotein 3	Mus musculus	73-76
11144299-2	2000	HLA-DRB1*0704 differed from DRB1*0701 by five consecutive nucleotides at positions 217 to 221 of exon 2 encoding two amino acids substitutions of tyrosine to asparagine at codons 77 and valine to tyrosine at codon 78.	Asparagine	158-168	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
11144299-2	2000	HLA-DRB1*0704 differed from DRB1*0701 by five consecutive nucleotides at positions 217 to 221 of exon 2 encoding two amino acids substitutions of tyrosine to asparagine at codons 77 and valine to tyrosine at codon 78.	Asparagine	158-168	major histocompatibility complex, class II, DR beta 1	Homo sapiens	4-8
11144300-6	2000	At the amino acid level, the DRB1*11272 mutation is silent with respect to the DRB*1127 phenotype, coding for a synonymous asparagine.	Asparagine	123-133	major histocompatibility complex, class II, DR beta 1	Homo sapiens	29-33
11041867-6	2000	In the light-minus-dark absorbance spectra, all mutations in PsaB exhibited an additional bleaching band at 665 nm at room temperature comparable with the published spectrum for the replacement of His(B656) with asparagine [Webber, A. N., Su Hui, Bingham, S. E., Kass, H., Krabben, L., Kuhn, M., Jordan, R., Schlodder, E., and Lubitz, W. (1996) Biochemistry 35, 12857-12863].	Asparagine	212-222	fatty acid amide hydrolase	Homo sapiens	61-65
10887184-1	2000	A mutational analysis of the Ras-binding domain (RBD) of c-Raf-1 identified three amino acid positions (Asn(64), Ala(85), and Val(88)) where amino acid substitution with basic residues increases the binding of RBD to recombinant v-Ha-Ras.	Asparagine	104-107	TNF receptor associated factor 3	Homo sapiens	57-64
10992007-0	2000	Identification of the sites of asparagine-linked glycosylation on the human thyrotropin receptor and studies on their role in receptor function and expression.	Asparagine	31-41	thyroid stimulating hormone receptor	Homo sapiens	76-96
10889209-5	2000	GIRK1 membrane-spanning domain 1 was required for optimal glycosylation at Asn(119) because a chimera that contained GIRK4 membrane-spanning domain 1 significantly reduced the addition of a carbohydrate structure at this site.	Asparagine	75-78	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	0-5
10893241-5	2000	Site-directed mutagenesis showed that Lys-521 and Asn-534 were required for optimum calmodulin binding and that restoration of these amino acids to the counterpart PTPepsilon sequence could confer calmodulin binding.	Asparagine	50-53	calmodulin 1	Homo sapiens	84-94
10878019-3	2000	We mutated the important contact sites Glu-89, Asn-90, and Asn-130 in RGS16 to lysine, aspartate, and alanine, respectively.	Asparagine	47-50	regulator of G-protein signaling 16	Rattus norvegicus	70-75
11027492-4	2000	In the primary structure of 11beta-HSD 1 three Asn-X-Ser glycosylation motifs have been identified.	Asparagine	47-50	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	28-40
10889209-5	2000	GIRK1 membrane-spanning domain 1 was required for optimal glycosylation at Asn(119) because a chimera that contained GIRK4 membrane-spanning domain 1 significantly reduced the addition of a carbohydrate structure at this site.	Asparagine	75-78	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	117-122
10889209-8	2000	Thus, N-glycosylation of GIRK1 at Asn(119) does not appear to affect its physical association with GIRK4, the routing of the heteromer to the cell surface, or heteromeric channel function, unlike the dramatic functional effects of N-glycosylation of ROMK1 at Asn(117) (Schwalbe, R. A., Wang, Z., Wible, B.	Asparagine	34-37	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	25-30
10878019-3	2000	We mutated the important contact sites Glu-89, Asn-90, and Asn-130 in RGS16 to lysine, aspartate, and alanine, respectively.	Asparagine	59-62	regulator of G-protein signaling 16	Rattus norvegicus	70-75
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Asparagine	170-173	EcoRII restriction enzyme	Escherichia coli	33-39
10837490-10	2000	In aggregate, these data indicate that the region of GP Ibalpha bounded by Asn(226) and Ala(244) regulates the affinity for vWf.	Asparagine	75-78	von Willebrand factor	Cricetulus griseus	124-127
10972975-6	2000	Horseradish peroxidase (HRP)-lectin staining showed that the 7721 cells transfected with nm23-H1 or the A549 cells transfected with p16 displayed a decreased intensity with HRP-leucoagglutinating phytohemagglutinin and increased intensity with HRP-concanavalin A, indicating the decline of beta1,6 N-acetylglucosamine branching structure on the asparagine-linked glycans of cell-surface and intracellular glycoproteins.	Asparagine	345-355	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	89-96
10972975-6	2000	Horseradish peroxidase (HRP)-lectin staining showed that the 7721 cells transfected with nm23-H1 or the A549 cells transfected with p16 displayed a decreased intensity with HRP-leucoagglutinating phytohemagglutinin and increased intensity with HRP-concanavalin A, indicating the decline of beta1,6 N-acetylglucosamine branching structure on the asparagine-linked glycans of cell-surface and intracellular glycoproteins.	Asparagine	345-355	cyclin dependent kinase inhibitor 2A	Homo sapiens	132-135
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Asparagine	170-173	EcoRII restriction enzyme	Escherichia coli	130-136
10825179-4	2000	McpB((Q371D,E630D,E637D)) in a Delta(mcpA mcpB tlpA tlpB)101::cat mcpC4::erm background failed to release methanol in response to either the addition or removal of the McpB-mediated attractant asparagine.	Asparagine	193-203	hlyB-like ABC transporter-like protein	Escherichia coli	0-4
10950805-3	2000	P. falciparum infections were analyzed by polymerase chain reaction for DHFR mutations, which were dramatically more frequent among prophylaxis-breakthrough infections than at baseline: the prevalence of Asn-108 rose from 13% to 100%, Ile-51 from 4% to 50%, and Arg-59 from 11% to 90%.	Asparagine	204-207	dihydrofolate reductase	Homo sapiens	72-76
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Asparagine	28-38	N-terminal Asn amidase	Mus musculus	0-5
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Asparagine	28-38	arginyltransferase 1	Mus musculus	88-92
10933783-10	2000	The mechanism of PPT was studied further by constructing and characterizing the kinetic properties of two mutants of Pro-1 (P1G and P1A) and one mutant of Asn-97 (N97A).	Asparagine	155-158	macrophage migration inhibitory factor	Homo sapiens	17-20
11007273-1	2000	Mimetics of beta-turn structures in proteins have been used to calibrate the relative reactivities toward deamidation of asparagine residues in the two central positions of a beta-turn and in a random coil.	Asparagine	121-131	amyloid beta precursor protein	Homo sapiens	173-179
11007273-7	2000	Thus the order of reactivity toward deamidation is: asparagine in a random coil approximately 3x(asparagine) in position 2 of a beta-turn approximately 30x (asparagine) in position 3 of a beta-turn.	Asparagine	97-107	amyloid beta precursor protein	Homo sapiens	126-132
11007273-7	2000	Thus the order of reactivity toward deamidation is: asparagine in a random coil approximately 3x(asparagine) in position 2 of a beta-turn approximately 30x (asparagine) in position 3 of a beta-turn.	Asparagine	97-107	amyloid beta precursor protein	Homo sapiens	126-132
10827201-2	2000	In this regard, we recently identified a mechanism in which processing by endoplasmic reticulum mannosidase I, which attenuates the removal of glucose from asparagine-linked oligosaccharides, sorts terminally misfolded alpha(1)-antitrypsin for proteasome-mediated degradation in response to its abrogated physical dissociation from calnexin (Liu, Y., Choudhury, P., Cabral, C., and Sifers, R. N. (1999) J. Biol.	Asparagine	156-166	serpin family A member 1	Homo sapiens	219-239
10827201-2	2000	In this regard, we recently identified a mechanism in which processing by endoplasmic reticulum mannosidase I, which attenuates the removal of glucose from asparagine-linked oligosaccharides, sorts terminally misfolded alpha(1)-antitrypsin for proteasome-mediated degradation in response to its abrogated physical dissociation from calnexin (Liu, Y., Choudhury, P., Cabral, C., and Sifers, R. N. (1999) J. Biol.	Asparagine	156-166	calnexin	Homo sapiens	332-340
10825179-5	2000	In the same background, McpB((E630D,E637D)) produced methanol only upon asparagine addition, whereas McpB((Q371D,E630D)) produced methanol only upon asparagine removal.	Asparagine	72-82	hlyB-like ABC transporter-like protein	Escherichia coli	24-28
10825179-5	2000	In the same background, McpB((E630D,E637D)) produced methanol only upon asparagine addition, whereas McpB((Q371D,E630D)) produced methanol only upon asparagine removal.	Asparagine	149-159	hlyB-like ABC transporter-like protein	Escherichia coli	101-105
10924110-2	2000	The in vivo electron transfer capability of Chlamydomonas reinhardtii cytochrome f was impaired in site-directed mutants of the conserved Asn and Gln residues that form hydrogen bonds with water molecules of the internal chain [Ponamarev, M. V., and Cramer, W. A.	Asparagine	138-141	cytochrome f	Chlamydomonas reinhardtii	70-82
10823827-6	2000	When expressed in Xenopus laevis oocytes, the transport of glutamine or asparagine via human SN1 was associated with inward currents under voltage-clamped conditions.	Asparagine	72-82	solute carrier family 38 member 3	Homo sapiens	93-96
10915101-3	2000	Of 12 different unmixed allelic combinations, the triple dhfr mutation Asn-108/Arg-59/Ile-51 was observed in all patients responding with early treatment failure.	Asparagine	71-74	dihydrofolate reductase	Homo sapiens	57-61
11073182-10	2000	CONCLUSIONS: The Asn/Ser genotype of the LPL gene is associated with dyslipidaemia in normoglycaemic subjects, and the dyslipidaemic phenotype is more severe in insulin-resistant subjects.	Asparagine	17-20	lipoprotein lipase	Homo sapiens	41-44
11073182-10	2000	CONCLUSIONS: The Asn/Ser genotype of the LPL gene is associated with dyslipidaemia in normoglycaemic subjects, and the dyslipidaemic phenotype is more severe in insulin-resistant subjects.	Asparagine	17-20	insulin	Homo sapiens	161-168
10899964-1	2000	The amino acid sequence of the glycopeptide obtained from bovine PASII/PMP22 protein in the PNS myelin was determined to be Gln-Asn-Cys-Ser-Thr, where the asparagine was glycosylated.	Asparagine	128-131	peripheral myelin protein 22	Bos taurus	65-70
10899964-1	2000	The amino acid sequence of the glycopeptide obtained from bovine PASII/PMP22 protein in the PNS myelin was determined to be Gln-Asn-Cys-Ser-Thr, where the asparagine was glycosylated.	Asparagine	128-131	peripheral myelin protein 22	Bos taurus	71-76
10899964-1	2000	The amino acid sequence of the glycopeptide obtained from bovine PASII/PMP22 protein in the PNS myelin was determined to be Gln-Asn-Cys-Ser-Thr, where the asparagine was glycosylated.	Asparagine	155-165	peripheral myelin protein 22	Bos taurus	65-70
10899964-1	2000	The amino acid sequence of the glycopeptide obtained from bovine PASII/PMP22 protein in the PNS myelin was determined to be Gln-Asn-Cys-Ser-Thr, where the asparagine was glycosylated.	Asparagine	155-165	peripheral myelin protein 22	Bos taurus	71-76
10922468-5	2000	Both MMPs hydrolysed aggrecan efficiently at the well-described MMP cleavage site between residues Asn(341) and Phe(342), as shown by Western blotting using neo-epitope antibodies.	Asparagine	99-102	matrix metallopeptidase 19	Homo sapiens	5-9
10935543-3	2000	A nonconservative asparagine to lysine substitution in AR residue 727 was encountered in a phenotypically normal man with subfertility and depressed spermatogenesis.	Asparagine	18-28	androgen receptor	Homo sapiens	55-57
10861238-3	2000	The epitope recognized by the anti-hEGF antibodies was further characterized using 8 chimaeras between hEGF and an EGF-repeat from Drosophila Notch and was found to include Met(21), Ala(30) and Asn(32).	Asparagine	194-197	epidermal growth factor	Homo sapiens	35-39
10908805-1	2000	The major cationic peanut (Arachis hypogaea) peroxidase, secreted into the extracellular space, is a glycoprotein with three N-linked glycans (polysaccharides) which are connected to the peptide backbone at Asn-60, Asn-144 and Asn-185.	Asparagine	207-210	peroxidase N1-like	Nicotiana tabacum	45-55
10908805-1	2000	The major cationic peanut (Arachis hypogaea) peroxidase, secreted into the extracellular space, is a glycoprotein with three N-linked glycans (polysaccharides) which are connected to the peptide backbone at Asn-60, Asn-144 and Asn-185.	Asparagine	215-218	peroxidase N1-like	Nicotiana tabacum	45-55
10908805-1	2000	The major cationic peanut (Arachis hypogaea) peroxidase, secreted into the extracellular space, is a glycoprotein with three N-linked glycans (polysaccharides) which are connected to the peptide backbone at Asn-60, Asn-144 and Asn-185.	Asparagine	215-218	peroxidase N1-like	Nicotiana tabacum	45-55
10861210-1	2000	The human erythrocyte anion exchanger (AE)1 (Band 3) contains a single complex N-linked oligosaccharide that is attached to Asn(642) in the fourth extracellular loop of this polytopic membrane protein, while other isoforms (AE2, AE3 and trout AE1) are N-glycosylated on the preceding extracellular loop.	Asparagine	124-127	solute carrier family 4 member 2	Homo sapiens	224-227
10861210-1	2000	The human erythrocyte anion exchanger (AE)1 (Band 3) contains a single complex N-linked oligosaccharide that is attached to Asn(642) in the fourth extracellular loop of this polytopic membrane protein, while other isoforms (AE2, AE3 and trout AE1) are N-glycosylated on the preceding extracellular loop.	Asparagine	124-127	solute carrier family 4 member 3	Homo sapiens	229-232
10861210-1	2000	The human erythrocyte anion exchanger (AE)1 (Band 3) contains a single complex N-linked oligosaccharide that is attached to Asn(642) in the fourth extracellular loop of this polytopic membrane protein, while other isoforms (AE2, AE3 and trout AE1) are N-glycosylated on the preceding extracellular loop.	Asparagine	124-127	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	243-246
10801876-0	2000	The Asn-420-linked sugar chain in human epidermal growth factor receptor suppresses ligand-independent spontaneous oligomerization.	Asparagine	4-7	epidermal growth factor receptor	Homo sapiens	40-72
10801876-2	2000	To elucidate a role(s) of Asn-linked sugar chain(s) in the function of epidermal growth factor receptor (EGFR), a series of the EGFR mutants were prepared in which potential glycosylation sites in the domain III were eliminated by site-directed mutagenesis.	Asparagine	26-29	epidermal growth factor receptor	Homo sapiens	71-103
10801876-2	2000	To elucidate a role(s) of Asn-linked sugar chain(s) in the function of epidermal growth factor receptor (EGFR), a series of the EGFR mutants were prepared in which potential glycosylation sites in the domain III were eliminated by site-directed mutagenesis.	Asparagine	26-29	epidermal growth factor receptor	Homo sapiens	105-109
10801876-7	2000	These findings suggest that the sugar chain linked to Asn-420 plays a crucial role in EGF binding and prevents spontaneous oligomerization of the EGFR, which may otherwise lead to uncontrollable receptor activation, and support the view of a specific role of an Asn-linked sugar chain in the function of a glycoprotein.	Asparagine	54-57	epidermal growth factor receptor	Homo sapiens	146-150
10781610-4	2000	Changing Glu-226, which corresponded to the catalytic residue of the cyclase, to Asp, Asn, Gln, Leu, or Gly eliminated essentially all enzymatic activities of CD38, indicating it is most likely the catalytic residue.	Asparagine	86-89	CD38 molecule	Homo sapiens	159-163
10873270-7	2000	From these digests the completely deglycosylated polypeptide corresponding to RNase A in which Asn has been converted to Asp (mass 13,684) and a species corresponding to RNase A + GlcNAc (mass 13,886) are produced, together with their corresponding free oligosaccharides which are amenable to analysis by both MALDI-ToF and by HPLC.	Asparagine	95-98	ribonuclease A family member 1, pancreatic	Homo sapiens	78-85
10864452-0	2000	The status of half-cystine residues and locations of N-glycosylated asparagine residues in human eosinophil peroxidase.	Asparagine	68-78	eosinophil peroxidase	Homo sapiens	97-118
10861238-3	2000	The epitope recognized by the anti-hEGF antibodies was further characterized using 8 chimaeras between hEGF and an EGF-repeat from Drosophila Notch and was found to include Met(21), Ala(30) and Asn(32).	Asparagine	194-197	Epidermal growth factor receptor	Drosophila melanogaster	36-39
10880057-2	2000	gp130-RAPS is a 50-kDa protein translated from alternatively spliced mRNA and has a truncated form of gp130 with a unique sequence, Asn-Ile-Ala-Ser-Phe (NIASF), in its COOH-terminus.	Asparagine	132-135	interleukin 6 cytokine family signal transducer	Homo sapiens	0-5
10866817-10	2000	Studies of the degradation products using methylation analysis, ESI MS, MALDI MS, and 1H and 13C NMR spectroscopy, including 1H,13C HMQC and NOESY experiments, established the structure of the unique Asn-linked hexasaccharide chain of cytochrome b558/566.	Asparagine	200-203	ATZ20_RS00215	Sulfolobus acidocaldarius	235-247
10839995-0	2000	Characterization of beta-galactosidase mutations Asp332--&gt;Asn and Arg148--&gt;Ser, and a polymorphism, Ser532--&gt;Gly, in a case of GM1 gangliosidosis.	Asparagine	61-64	galactosidase beta 1	Homo sapiens	20-38
10871637-15	2000	Negative charge substitutions of the neutral asparagine residue present in wild-type Cx32 (Cx32N2E or Cx32N2D) reverse the gating polarity of Cx32 hemichannels from closure at negative Vj to closure at positive Vj.	Asparagine	45-55	gap junction protein beta 1 L homeolog	Xenopus laevis	85-89
10871637-15	2000	Negative charge substitutions of the neutral asparagine residue present in wild-type Cx32 (Cx32N2E or Cx32N2D) reverse the gating polarity of Cx32 hemichannels from closure at negative Vj to closure at positive Vj.	Asparagine	45-55	gap junction protein beta 1 L homeolog	Xenopus laevis	102-109
10871637-15	2000	Negative charge substitutions of the neutral asparagine residue present in wild-type Cx32 (Cx32N2E or Cx32N2D) reverse the gating polarity of Cx32 hemichannels from closure at negative Vj to closure at positive Vj.	Asparagine	45-55	gap junction protein beta 1 L homeolog	Xenopus laevis	91-95
11004541-1	2000	The C-terminal residue of the insulin A chain is invariant and kept as asparagine in all known insulin molecules from hagfish through birds to mammals.	Asparagine	71-81	insulin	Homo sapiens	30-37
10856224-4	2000	A single nucleotide mutation in the cathepsin D gene results in conversion of an active site aspartate to asparagine, leading to production of an enzymatically inactive but stable protein.	Asparagine	106-116	cathepsin D	Homo sapiens	36-47
11004541-1	2000	The C-terminal residue of the insulin A chain is invariant and kept as asparagine in all known insulin molecules from hagfish through birds to mammals.	Asparagine	71-81	insulin	Homo sapiens	95-102
10748160-2	2000	The mutation of the Asn/Asp residue of this motif in different G-protein-coupled receptors was shown to affect the activation of either adenylyl cyclase or phospholipase C. We have mutated the Asn residue (Asn-391) of the NPXXY motif in the CCKBR to Ala and determined the effects of the mutation on binding, signaling, and G-proteins coupling after expression of the mutated receptor in COS cells.	Asparagine	20-23	cholecystokinin B receptor	Homo sapiens	241-246
10748160-0	2000	Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor.	Asparagine	12-15	cholecystokinin B receptor	Homo sapiens	60-86
10863096-6	2000	The reduction of the molecular mass of the recombinant ME1 protein with the digestion of glycopeptidase A indicated that it is modified by Asn-linked glycosylation.	Asparagine	139-142	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	55-58
10748160-2	2000	The mutation of the Asn/Asp residue of this motif in different G-protein-coupled receptors was shown to affect the activation of either adenylyl cyclase or phospholipase C. We have mutated the Asn residue (Asn-391) of the NPXXY motif in the CCKBR to Ala and determined the effects of the mutation on binding, signaling, and G-proteins coupling after expression of the mutated receptor in COS cells.	Asparagine	193-196	cholecystokinin B receptor	Homo sapiens	241-246
10748160-2	2000	The mutation of the Asn/Asp residue of this motif in different G-protein-coupled receptors was shown to affect the activation of either adenylyl cyclase or phospholipase C. We have mutated the Asn residue (Asn-391) of the NPXXY motif in the CCKBR to Ala and determined the effects of the mutation on binding, signaling, and G-proteins coupling after expression of the mutated receptor in COS cells.	Asparagine	193-196	cholecystokinin B receptor	Homo sapiens	241-246
10816435-5	2000	Glycine, L-asparagine and L-serine, as well as their D-enantiomers, were the strongest effectors and acted in a concentration-dependent manner; millimolar concentrations of most of these amino acids being sufficient to significantly increase ODC activity.	Asparagine	9-21	ornithine decarboxylase 1	Homo sapiens	242-245
10892731-2	2000	Our investigation of several proteins, amongst others beta2-microglobulin and the haptoglobin chains, found the differences in isoelectric points (p/) to be due to deamidation of asparagines.	Asparagine	179-190	beta-2-microglobulin	Homo sapiens	54-73
10886198-6	2000	As the original amino acid (Asn) is conserved in all known FVIII A2 sequences, but not in ceruloplasmin, we suggest that Asn694 is involved in an A2-specific functional role.	Asparagine	28-31	coagulation factor VIII	Homo sapiens	59-64
10892731-2	2000	Our investigation of several proteins, amongst others beta2-microglobulin and the haptoglobin chains, found the differences in isoelectric points (p/) to be due to deamidation of asparagines.	Asparagine	179-190	haptoglobin	Homo sapiens	82-93
10814706-1	2000	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase (alpha1,6FucT) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1,6-linkage.	Asparagine	149-159	fucosyltransferase 8	Homo sapiens	0-67
10814706-1	2000	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase (alpha1,6FucT) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1,6-linkage.	Asparagine	149-159	fucosyltransferase 8	Homo sapiens	69-81
10833268-0	2000	Comparative study of the asparagine-linked sugar chains of human lipocalin-type prostaglandin D synthase purified from urine and amniotic fluid, and recombinantly expressed in Chinese hamster ovary cells.	Asparagine	25-35	prostaglandin D2 synthase	Homo sapiens	65-104
10833268-2	2000	We comparatively analyzed the structures of asparagine-linked sugar chains of human L-PGDS produced by recombinant Chinese hamster ovary cells and naturally occurring human urine and amniotic fluid.	Asparagine	44-54	prostaglandin D2 synthase	Homo sapiens	84-90
10805775-5	2000	We propose a model in which the asparagine-proline sequence serves as an NH(2)-terminal cap for a portion of the transmembrane alpha-helix of SREBP, allowing the remainder of the alpha-helix to unwind partially to expose the peptide bond for cleavage by S2P.	Asparagine	32-42	membrane bound transcription factor peptidase, site 2	Homo sapiens	254-257
10850706-7	2000	Most contacts in the complex are between KIR and conserved HLA-C residues, but a hydrogen bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.	Asparagine	125-128	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	41-44
10850706-7	2000	Most contacts in the complex are between KIR and conserved HLA-C residues, but a hydrogen bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.	Asparagine	125-128	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	113-120
10805755-7	2000	Among the normally short-lived N-end rule substrates, only those bearing N-terminal asparagine became long-lived in Ntan1(-/-) fibroblasts.	Asparagine	84-94	N-terminal Asn amidase	Mus musculus	116-121
10805775-0	2000	Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.	Asparagine	0-10	membrane bound transcription factor peptidase, site 2	Homo sapiens	105-120
10837925-6	2000	More interestingly, the product of N-acetylasparagine was aspartate but not asparagine, indicating that ASPA catalyzed deacetylation as well as hydrolysis of the beta acid amide.	Asparagine	43-53	aspartoacylase	Homo sapiens	104-108
10779384-6	2000	Sequence comparison of PDE4 with cGMP-specific PDE proteins shows a conserved aspartic acid at position 333 in PDE4D3 and a conserved asparagine at this position in PDE enzymes that hydrolyze cGMP.	Asparagine	134-144	phosphodiesterase 4A	Homo sapiens	23-27
10736265-9	2000	Resequencing of the GK gene in family members led to the discovery of a N288D missense mutation in exon 10, which resulted in the substitution of a highly conserved asparagine residue by a negatively charged aspartic acid.	Asparagine	165-175	glycerol kinase	Homo sapiens	20-22
10805333-2	2000	We report three novel mutations in the mitochondrial ornithine transporter gene (ORNT1) of Japanese patients with HHH syndrome: a nonsense mutation (R179X) associated with exon skipping and a frameshift, a missense mutation (G27E), and an insertion of AAC between codons 228 and 229, leading to an insertion of the amino acid Asn.	Asparagine	326-329	solute carrier family 25 member 15	Homo sapiens	81-86
10820080-1	2000	Asparagine synthetase B (AS) is the primary enzyme responsible for asparagine synthesis in plants.	Asparagine	67-77	asparagine synthetase	Glycine max	0-21
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	90-93	erythropoietin	Homo sapiens	0-14
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	90-93	erythropoietin	Homo sapiens	16-19
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	98-101	erythropoietin	Homo sapiens	0-14
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	98-101	erythropoietin	Homo sapiens	16-19
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	98-101	erythropoietin	Homo sapiens	0-14
10764840-1	2000	Erythropoietin (Epo) is a 166 amino acids protein containing three N-glycosylation sites (Asn-24, Asn-38, and Asn-83) and 1 O- glycosylation site (Ser-126) and involved in the regulation of the level of red blood cells.	Asparagine	98-101	erythropoietin	Homo sapiens	16-19
10764842-6	2000	Elimination of the oligosaccharide attached to Asn 158 in the full length STtyr single and double glycosylation mutants generates proteins that are not cleaved and secreted but stably localized in the Golgi, like the STcys isoform of the ST6Gal I.	Asparagine	47-50	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	238-246
10779387-7	2000	Using polymerase chain reaction, tyrosine 186 in AQP1, selected for its proximity to the mercury-binding site, was mutated to phenylalanine (Y186F), alanine (Y186A), or asparagine (Y186N).	Asparagine	169-179	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
10779384-8	2000	PDE4D3 Asp-Asn hydrolyzes cGMP with kinetic constants similar to those observed for this protein with cAMP (K(m) approximately 20 microM, V(max) approximately 2 micromol AMP/min/mg recombinant protein).	Asparagine	11-14	phosphodiesterase 4D	Homo sapiens	0-5
18944551-3	2000	The substitution of Ile for Arg at position 180 in the conserved motif Phe-Arg-Asn-Lys (FRNK) of potyviruses was found to affect symptom expression.	Asparagine	79-82	protein tyrosine kinase 2	Homo sapiens	88-92
10777559-5	2000	v-Crk activation of JNK was inhibited by a dominant-negative mutant of R-Ras, R-Ras(Asn-43).	Asparagine	84-87	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	2-5
10777559-5	2000	v-Crk activation of JNK was inhibited by a dominant-negative mutant of R-Ras, R-Ras(Asn-43).	Asparagine	84-87	mitogen-activated protein kinase 8	Mus musculus	20-23
10777559-5	2000	v-Crk activation of JNK was inhibited by a dominant-negative mutant of R-Ras, R-Ras(Asn-43).	Asparagine	84-87	related RAS viral (r-ras) oncogene	Mus musculus	71-76
10777559-5	2000	v-Crk activation of JNK was inhibited by a dominant-negative mutant of R-Ras, R-Ras(Asn-43).	Asparagine	84-87	related RAS viral (r-ras) oncogene	Mus musculus	78-83
10812183-7	2000	After 3 days of exposure to serum, glucose, glutamate and asparagine deprivation, the viable cell number and viability were significantly higher in the bcl-2 transfected cell line.	Asparagine	58-68	B cell leukemia/lymphoma 2	Mus musculus	152-157
10749666-4	2000	In the present study, examination of SERP-1 glycosylation-site mutants showed that the N-linked glycosylation of Asn(172) was essential for SERP-1 secretion, whereas mutation of Asn(99) decreased secretion efficiency, indicating that N-linked glycosylation plays an essential role in the processing and trafficking of SERP-1.	Asparagine	113-116	stress associated endoplasmic reticulum protein 1	Homo sapiens	37-43
10766996-4	2000	The DNA sequencing demonstrated novel mutations in exon 3A of AT3: a G to T substitution at nucleotide position 5333 in codon GAG for Glu 113, causing a stop codon (E113X), and an A to T substitution at position 5338 in codon AAA for Lys 114, forming Asn (K114N).	Asparagine	251-254	serpin family C member 1	Homo sapiens	62-65
10757979-0	2000	Solution structure of Eps15"s third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.	Asparagine	77-80	epidermal growth factor receptor pathway substrate 15	Homo sapiens	22-27
10749666-4	2000	In the present study, examination of SERP-1 glycosylation-site mutants showed that the N-linked glycosylation of Asn(172) was essential for SERP-1 secretion, whereas mutation of Asn(99) decreased secretion efficiency, indicating that N-linked glycosylation plays an essential role in the processing and trafficking of SERP-1.	Asparagine	113-116	stress associated endoplasmic reticulum protein 1	Homo sapiens	140-146
10749666-4	2000	In the present study, examination of SERP-1 glycosylation-site mutants showed that the N-linked glycosylation of Asn(172) was essential for SERP-1 secretion, whereas mutation of Asn(99) decreased secretion efficiency, indicating that N-linked glycosylation plays an essential role in the processing and trafficking of SERP-1.	Asparagine	113-116	stress associated endoplasmic reticulum protein 1	Homo sapiens	140-146
10744717-6	2000	In contrast, the basic nitrogen causes repulsion in other PTPs containing an asparagine in the equivalent position resulting in a remarkable selectivity for PTP1B.	Asparagine	77-87	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	157-162
10753886-2	2000	A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).	Asparagine	161-171	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	134-141
10753886-2	2000	A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).	Asparagine	161-171	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	211-218
10771511-1	2000	As part of our effort to identify glycoproteins that contribute to colon cancer progression, we have previously described a family of structurally related glycoproteins expressing beta1-6 branched asparagine(Asn)-linked oligosaccharides defined by monoclonal antibody (MAb 1H9), which are differentially expressed, processed, and glycosylated by human colon carcinoma cell lines (Laferte and Loh [1992]; Biochem J; 283:193-201).	Asparagine	208-211	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	180-187
10744747-3	2000	However, a phospholamban Asn(27) --&gt; Ala (N27A) mutant, which maintained a normal pentamer to monomer ratio, was shown to act as a superinhibitor of SERCA2a Ca(2+) affinity.	Asparagine	25-28	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	152-159
10727410-6	2000	The best substrates for cathepsins L and B had Trp and Asn at P(2)" respectively; variations at this position were less accepted by these enzymes.	Asparagine	55-58	cathepsin L	Homo sapiens	24-42
10716671-12	2000	CONCLUSIONS: Human TFF2 is glycosylated via an N-linkage, presumably on Asn(15) which forms part of the single consensus site for N-glycosylation in human TFF2.	Asparagine	72-75	trefoil factor 2	Homo sapiens	19-23
10716671-12	2000	CONCLUSIONS: Human TFF2 is glycosylated via an N-linkage, presumably on Asn(15) which forms part of the single consensus site for N-glycosylation in human TFF2.	Asparagine	72-75	trefoil factor 2	Homo sapiens	155-159
10733977-5	2000	The Asn, Thr, and Gly residues involved in hydrogen bonding to the DNA bases and sugar oxygens form a relatively rigid motif in TBP.	Asparagine	4-7	TATA-box binding protein	Homo sapiens	128-131
10727232-2	2000	Here, we studied the role of conserved Asn residues in the leucine-rich repeats of GP Ib alpha, the ligand-binding subunit of the complex.	Asparagine	39-42	glycoprotein Ib platelet subunit alpha	Homo sapiens	83-94
10791783-0	2000	Presence of a glycan at a potential N-glycosylation site, Asn-281, of bovine lactoferrin.	Asparagine	58-61	lactotransferrin	Bos taurus	77-88
10791783-4	2000	On the other hand, a glycopeptide glycosylated at Asn-281 was only detected in hydrolysate of bovine lactoferrin-a, indicating that bovine lactoferrin-a possessed five N-glycosylated sites.	Asparagine	50-53	lactotransferrin	Bos taurus	101-112
10791783-4	2000	On the other hand, a glycopeptide glycosylated at Asn-281 was only detected in hydrolysate of bovine lactoferrin-a, indicating that bovine lactoferrin-a possessed five N-glycosylated sites.	Asparagine	50-53	lactotransferrin	Bos taurus	139-150
10791783-5	2000	The glycan linked to Asn-281 of bovine lactoferrin-a was found to consist of fucose, galactose, and N-acetylgalactosamine in addition to mannose and N-acetylglucosamine.	Asparagine	21-24	lactotransferrin	Bos taurus	39-50
10729336-1	2000	NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R).	Asparagine	68-78	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	106-109
10727232-7	2000	These results suggest a vital role for the conserved asparagine residues in the leucine-rich repeats of GP Ib alpha for the structure and functions of this polypeptide.	Asparagine	53-63	glycoprotein Ib platelet subunit alpha	Homo sapiens	104-115
10702222-7	2000	Immunofluorescence analyses indicate that HA-RhoA(Asn-19) is excluded from the nucleus and cell junctions.	Asparagine	50-53	transforming protein RhoA	Cricetulus griseus	45-49
10704201-3	2000	The recombinant variants (i.e., H207N and E287Q) are enzymes in which the conserved amino acids histidine-207 and glutamate-287 of murine ferrochelatase were substituted with asparagine and glutamine, respectively.	Asparagine	175-185	ferrochelatase	Mus musculus	138-152
10713140-5	2000	Analysis of the folding pathway and activity of 15 tyrosinase mutants lacking one or more of the occupied N-glycosylation sites shows that glycans at any two N-glycosylation sites are sufficient to interact with calnexin and give partial activity, but a specific pair of sites (Asn(86) and Asn(371)) is required for full activity.	Asparagine	278-281	tyrosinase	Homo sapiens	51-61
10713140-5	2000	Analysis of the folding pathway and activity of 15 tyrosinase mutants lacking one or more of the occupied N-glycosylation sites shows that glycans at any two N-glycosylation sites are sufficient to interact with calnexin and give partial activity, but a specific pair of sites (Asn(86) and Asn(371)) is required for full activity.	Asparagine	290-293	tyrosinase	Homo sapiens	51-61
10762004-6	2000	Enzyme SULT1A2*Thr is less active than SULT1A2*Asn.	Asparagine	47-50	sulfotransferase family 1A member 2	Homo sapiens	7-14
10702222-3	2000	Dominant negative RhoA(Asn-19) co-precipitates with the guanine nucleotide exchange factor (GEF) SmgGDS but does not detectably interact with other expressed GEFs, such as Ost or Dbl.	Asparagine	23-26	transforming protein RhoA	Cricetulus griseus	18-22
10762004-6	2000	Enzyme SULT1A2*Thr is less active than SULT1A2*Asn.	Asparagine	47-50	sulfotransferase family 1A member 2	Homo sapiens	39-46
10762004-10	2000	Allele frequencies were 0.63 and 0.37 for SULT1A1*Arg and *His, and 0.62 and 0.38 for SULT1A2*Asn and *Thr, respectively.	Asparagine	94-97	sulfotransferase family 1A member 2	Homo sapiens	86-93
10762004-11	2000	The frequency of the haplotype SULT1A1*Arg/SULT1A2*Asn (0.61) was nearly as high as the allele frequencies of its components.	Asparagine	51-54	sulfotransferase family 1A member 1	Homo sapiens	31-38
10762004-11	2000	The frequency of the haplotype SULT1A1*Arg/SULT1A2*Asn (0.61) was nearly as high as the allele frequencies of its components.	Asparagine	51-54	sulfotransferase family 1A member 2	Homo sapiens	43-50
10762004-15	2000	The results demonstrate a strong association of the alleles producing the more active enzyme variants (SULT1A1*Arg and SULT1A2*Asn) and of those encoding the less active variants (SULT1A1*His and SULT1A2*Thr).	Asparagine	127-130	sulfotransferase family 1A member 2	Homo sapiens	119-126
10762004-15	2000	The results demonstrate a strong association of the alleles producing the more active enzyme variants (SULT1A1*Arg and SULT1A2*Asn) and of those encoding the less active variants (SULT1A1*His and SULT1A2*Thr).	Asparagine	127-130	sulfotransferase family 1A member 1	Homo sapiens	180-187
10679288-2	2000	Asn-linked glycan portion was released from 100 microg of osteopontin by digestion with glycoamidase A (from sweet almond), and the reducing ends of the N-glycans were reductively aminated with 2-aminopyridine.	Asparagine	0-3	secreted phosphoprotein 1	Homo sapiens	58-69
10761754-12	2000	L-ASN levels may be undetectable also in patients with L-ASE trough activity levels &lt; 50 mU/ml, challenging the current opinion that an activity level of 100 mU/ml is needed to obtain L-ASN depletion.	Asparagine	0-5	arylsulfatase L	Homo sapiens	57-60
10715549-0	2000	Additional N-glycosylation at Asn(13) rescues the human LHbeta-subunit from disulfide-linked aggregation.	Asparagine	30-33	luteinizing hormone subunit beta	Homo sapiens	56-62
10715549-4	2000	No aggregation was seen when N-linked oligosaccharides were attached to the Asn(13) of LHbeta.	Asparagine	76-79	luteinizing hormone subunit beta	Homo sapiens	87-93
10715549-5	2000	Removal of the carbohydrate unit at the Asn(13) of CGbeta caused aggregation, although the amount was less than 10% of monomer.	Asparagine	40-43	chorionic gonadotropin subunit beta 3	Homo sapiens	51-57
10715549-7	2000	Both CGbeta wild-type (WT) and CGbeta lacking N-glycosylation at Asn(13) (CGbeta-N13) showed aggregates in lysate.	Asparagine	65-68	chorionic gonadotropin subunit beta 3	Homo sapiens	5-11
10715549-7	2000	Both CGbeta wild-type (WT) and CGbeta lacking N-glycosylation at Asn(13) (CGbeta-N13) showed aggregates in lysate.	Asparagine	65-68	chorionic gonadotropin subunit beta 3	Homo sapiens	31-37
10715549-7	2000	Both CGbeta wild-type (WT) and CGbeta lacking N-glycosylation at Asn(13) (CGbeta-N13) showed aggregates in lysate.	Asparagine	65-68	chorionic gonadotropin subunit beta 3	Homo sapiens	31-37
10715549-9	2000	These results indicate that the backbone structure consisting of 114 amino acids and N-linked glycosylation at Asn(30) is involved in the aggregation of LHbeta.	Asparagine	111-114	luteinizing hormone subunit beta	Homo sapiens	153-159
10715549-10	2000	Moreover, N-glycosylation at Asn(13) does not prevent such aggregation, but instead plays an important role in correct folding for both LHbeta- and CGbeta-subunits to be secreted as monomer.	Asparagine	29-32	luteinizing hormone subunit beta	Homo sapiens	136-142
10715549-10	2000	Moreover, N-glycosylation at Asn(13) does not prevent such aggregation, but instead plays an important role in correct folding for both LHbeta- and CGbeta-subunits to be secreted as monomer.	Asparagine	29-32	chorionic gonadotropin subunit beta 3	Homo sapiens	148-154
10767822-1	2000	BACKGROUND: Familial amyloidosis of the Finnish type (FAF, Finnish hereditary amyloidosis) is caused by a 654G-A mutation in the gelsolin gene on chromosome 9 resulting in the expression of mutant Asn-187 gelsolin which is abnormally proteolytically processed generating amyloidogenic fragments that polymerize into amyloid fibrils.	Asparagine	197-200	gelsolin	Homo sapiens	129-137
10679625-2	2000	The amino acid sequence of these peptides is similar to the local sequence flanking the labile Asn-67 in RNAse A.	Asparagine	95-98	ribonuclease A family member 1, pancreatic	Homo sapiens	105-112
10642608-3	2000	Since PSA is a glycoprotein with one asparagine linked oligosaccharide, and since malignant transformation often leads to an increased branching of such oligosaccharides, we initially studied the asparagine linked structures on PSA made by a cell line derived from malignant metastatic prostate tissue.	Asparagine	37-47	kallikrein related peptidase 3	Homo sapiens	6-9
10691677-3	2000	The difference in the molecular mass between these two proteins could be due to the native P34 in soybean being glycosylated at position Asn(170), whereas the recombinant protein generated in E. coli lacks this post-translational modification.	Asparagine	137-140	P34 probable thiol protease	Glycine max	91-94
10767822-1	2000	BACKGROUND: Familial amyloidosis of the Finnish type (FAF, Finnish hereditary amyloidosis) is caused by a 654G-A mutation in the gelsolin gene on chromosome 9 resulting in the expression of mutant Asn-187 gelsolin which is abnormally proteolytically processed generating amyloidogenic fragments that polymerize into amyloid fibrils.	Asparagine	197-200	gelsolin	Homo sapiens	205-213
10646536-5	2000	When the serine residue present in the wild-type nonresponsive beta1 subunit is replaced by an asparagine found in the same position in the beta3 subunit, the resulting point-mutated beta1S265N forms receptors responsive to intravenous general anesthetics, like the wild-type beta3 subunits.	Asparagine	95-105	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	140-145
10646536-5	2000	When the serine residue present in the wild-type nonresponsive beta1 subunit is replaced by an asparagine found in the same position in the beta3 subunit, the resulting point-mutated beta1S265N forms receptors responsive to intravenous general anesthetics, like the wild-type beta3 subunits.	Asparagine	95-105	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	276-281
10667916-1	2000	P-glycoprotein (P-gp), the product of human MDR1 gene, which functions as an ATP-dependent drug efflux pump, is N-linked glycosylated at asparagine residues 91, 94, and 99 located within the first extracellular loop.	Asparagine	137-147	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
10667916-1	2000	P-glycoprotein (P-gp), the product of human MDR1 gene, which functions as an ATP-dependent drug efflux pump, is N-linked glycosylated at asparagine residues 91, 94, and 99 located within the first extracellular loop.	Asparagine	137-147	ATP binding cassette subfamily B member 1	Homo sapiens	16-20
10625674-8	2000	ECF-L retains those amino acids highly conserved among chitinase family proteins, but Asp and Glu residues essential for the proton donation in hydrolysis were replaced by Asn and Gln, respectively.	Asparagine	172-175	chitinase-like 3	Mus musculus	0-5
10667916-1	2000	P-glycoprotein (P-gp), the product of human MDR1 gene, which functions as an ATP-dependent drug efflux pump, is N-linked glycosylated at asparagine residues 91, 94, and 99 located within the first extracellular loop.	Asparagine	137-147	ATP binding cassette subfamily B member 1	Homo sapiens	44-48
10607909-8	2000	Further, the amino acid at position 51, which is invariably an asparagine in other homeodomains and is known to contact DNA directly, is a methionine in the homeodomains of both Psx-1 and Psx-2.	Asparagine	63-73	reproductive homeobox 6	Mus musculus	178-183
10607909-8	2000	Further, the amino acid at position 51, which is invariably an asparagine in other homeodomains and is known to contact DNA directly, is a methionine in the homeodomains of both Psx-1 and Psx-2.	Asparagine	63-73	reproductive homeobox 9	Mus musculus	188-193
11094439-5	2000	The conformation of PR3 is stabilized by four disulfide bonds and, to a lesser extent, by asparagine-linked glycosylation.	Asparagine	90-100	proteinase 3	Homo sapiens	20-23
10949666-9	2000	Accumulation of an immunopositive cell specific asparagine-linked (N-linked) glycoprotein, Factor VIII:C in the absence of Glc3Man9GlcNAc2-PP-Dol in tunicamycin treated cells has been proposed as an apoptotic triggering mechanism under the current experimental conditions.	Asparagine	48-58	coagulation factor VIII	Bos taurus	91-102
10966453-4	2000	They are formed by glucosidase I- and II-catalyzed partial deglucosylation of the oligosaccharide transferred from dolichol diphosphate derivatives to Asn residues in nascent polypeptide chains (Glc3Man9GlcNAc2).	Asparagine	151-154	mannosyl-oligosaccharide glucosidase	Homo sapiens	19-32
11582573-0	2000	Formation of an RNase A derivative containing an aminosuccinyl residue in place of asparagine 67.	Asparagine	83-93	ribonuclease A family member 1, pancreatic	Homo sapiens	16-23
10861385-3	2000	The D21N mutant (Asp21 --&gt; Asn) of the SH3 yielded a UV CD distinct from that of the wild type, and its spectral changes induced by RLP1 binding were smaller and different from those of the wild type in absorption, CD, and UVRR spectra, suggesting that the mutation of conserved Asp21 affected the conformation of the ligand binding cleft and thus might lead to the decrease in the ligand affinity.	Asparagine	30-33	beta-secretase 2	Homo sapiens	17-22
10861385-3	2000	The D21N mutant (Asp21 --&gt; Asn) of the SH3 yielded a UV CD distinct from that of the wild type, and its spectral changes induced by RLP1 binding were smaller and different from those of the wild type in absorption, CD, and UVRR spectra, suggesting that the mutation of conserved Asp21 affected the conformation of the ligand binding cleft and thus might lead to the decrease in the ligand affinity.	Asparagine	30-33	phospholipase A and acyltransferase 5	Homo sapiens	135-139
10630424-3	2000	Bovine glycine N-acyltransferase catalyzed conjugation of benzoyl-CoA with Gly (Km(Gly) = 6.2 mM), Asn (Km(Asn) = 129 mM), Gln (Km(Gln) = 353 mM), Ala (Km(Ala) = 1573 mM), Glu (Km(Glu) = 1148 mM) as well as Ser in a sequential mechanism.	Asparagine	99-102	glycine N-acyltransferase	Bos taurus	7-32
10861385-3	2000	The D21N mutant (Asp21 --&gt; Asn) of the SH3 yielded a UV CD distinct from that of the wild type, and its spectral changes induced by RLP1 binding were smaller and different from those of the wild type in absorption, CD, and UVRR spectra, suggesting that the mutation of conserved Asp21 affected the conformation of the ligand binding cleft and thus might lead to the decrease in the ligand affinity.	Asparagine	30-33	beta-secretase 2	Homo sapiens	282-287
10646852-4	2000	This alternative splicing leads to the deletion of 44 amino acid residues (amino acids 45-88) from mature PSA, resulting in the loss of asparagine 45, which is a binding site for a carbohydrate chain.	Asparagine	136-146	kallikrein related peptidase 3	Homo sapiens	106-109
10651940-5	2000	The GPI anchor addition site of rat CD59 (Asn-79) was replaced either by a stop codon to produce rsCD59, or with the sequence of the first five short consensus repeats of Crry to produce rsCD59-Crry.	Asparagine	42-45	CD59 molecule	Rattus norvegicus	36-40
10629176-2	2000	The C. albicans Mig1 protein (CaMig1) differs from ScMig1, in that, among other things, it lacks a putative phosphorylation site for Snf1 and presents several long stretches rich in glutamine or in asparagine, serine, and threonine and has the effector domain located at some distance (50 amino acids) from the carboxy terminus.	Asparagine	198-208	transcription factor MIG1	Saccharomyces cerevisiae S288C	16-20
10630424-3	2000	Bovine glycine N-acyltransferase catalyzed conjugation of benzoyl-CoA with Gly (Km(Gly) = 6.2 mM), Asn (Km(Asn) = 129 mM), Gln (Km(Gln) = 353 mM), Ala (Km(Ala) = 1573 mM), Glu (Km(Glu) = 1148 mM) as well as Ser in a sequential mechanism.	Asparagine	107-110	glycine N-acyltransferase	Bos taurus	7-32
10721670-1	2000	We found a novel A--&gt;C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position.	Asparagine	100-103	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	53-57
10620137-0	2000	A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens.	Asparagine	8-18	keratin 2	Homo sapiens	68-78
10721670-1	2000	We found a novel A--&gt;C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position.	Asparagine	100-103	glycine-N-acyltransferase	Homo sapiens	105-108
10721678-5	2000	This Asn residue is located within the DNA-binding high-mobility-group (HMG) motif, which is considered to be the main functional domain of the SRY protein.	Asparagine	5-8	sex determining region Y	Homo sapiens	144-147
10721678-6	2000	Further, this amino acid, Asn, is a conserved residue among mammalian SRY genes.	Asparagine	26-29	sex determining region Y	Homo sapiens	70-73
10608835-2	1999	Previous studies have shown that Imp1p cleaves signal peptides having asparagine at the -1 position, which deviates from the typical signal peptide possessing a small uncharged amino acid at this position.	Asparagine	70-80	endopeptidase catalytic subunit IMP1	Saccharomyces cerevisiae S288C	33-38
10611245-3	2000	In addition, the ESX1 protein contains several notable features that are not often associated with homeoproteins, including an atypical homeodomain of the paired-like class, a proline-rich region that contains an SH3 binding motif, and a novel repeat region consisting of prolines alternating with phenylalanines or asparagines that we term the PF/PN motif.	Asparagine	316-327	ESX homeobox 1	Homo sapiens	17-21
11055120-7	2000	Two A--&gt;G transitions are detected, and it resulted in corresponding changes of amino acid (Asn--&gt;Asp and Glu--&gt;Gly) in the HSL protein, respectively.	Asparagine	95-98	lipase E, hormone sensitive type	Sus scrofa	133-136
10608835-7	1999	The data demonstrate that (i) although the -1 residue is important in substrates recognized by Imp1p, signal peptides having standard and nonstandard cleavage sites can be processed by Imp1p, and (ii) a -1 asparagine does not govern the substrate specificity of the inner membrane protease subunits.	Asparagine	206-216	endopeptidase catalytic subunit IMP1	Saccharomyces cerevisiae S288C	95-100
10608835-7	1999	The data demonstrate that (i) although the -1 residue is important in substrates recognized by Imp1p, signal peptides having standard and nonstandard cleavage sites can be processed by Imp1p, and (ii) a -1 asparagine does not govern the substrate specificity of the inner membrane protease subunits.	Asparagine	206-216	endopeptidase catalytic subunit IMP1	Saccharomyces cerevisiae S288C	185-190
10585457-2	1999	Like many G protein-coupled receptors, the gonadotropin-releasing hormone (GnRH) receptor contains an apolar amino acid in this region at a constant distance from conserved Pro and Tyr/Asn residues in the fifth transmembrane domain (TM V).	Asparagine	185-188	gonadotropin releasing hormone receptor	Homo sapiens	43-89
10585855-1	1999	The red-cell anion exchanger (band 3; AE1) is a multispanning membrane protein that traverses the bilayer up to 14 times and is N-glycosylated at Asn-642.	Asparagine	146-149	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	38-41
10585460-5	1999	Replacement of the aspartate with alanine, asparagine, glutamate, or glutamine in N(t)-FDH resulted in complete loss of hydrolase activity.	Asparagine	43-53	aldehyde dehydrogenase 1 family member L1	Homo sapiens	82-90
10601628-5	1999	The site of glycosylation is Asn(59), the only asparagine in the amino acid sequence contained in the N-glycosylation site consensus sequence, N-A-S. Ser(61), which is part of this site, is phosphorylated in OC-17 but not in OC-23 indicating that the two modifications are mutually exclusive.	Asparagine	29-32	ovocleidin 17	Gallus gallus	208-213
10654085-3	1999	Radiolabelled amino-acid uptake measurements showed that Agp1p is a general permease for most uncharged amino acids (Ala, Gly, Ser, Thr, Cys, Met, Phe, Tyr, Ile, Leu, Val, Gln and Asn).	Asparagine	180-183	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	57-62
10654085-4	1999	Gnp1p, which is closely related to Agp1p, has a somewhat less-broad specificity, transporting Leu, Ser, Thr, Cys, Met, Gln and Asn, while Bap2p and Bap3p, which are also closely related to Agp1p, are able to transport Ile, Leu, Val, Cys, Met, Phe, Tyr and Trp.	Asparagine	127-130	glutamine permease GNP1	Saccharomyces cerevisiae S288C	0-5
10654085-4	1999	Gnp1p, which is closely related to Agp1p, has a somewhat less-broad specificity, transporting Leu, Ser, Thr, Cys, Met, Gln and Asn, while Bap2p and Bap3p, which are also closely related to Agp1p, are able to transport Ile, Leu, Val, Cys, Met, Phe, Tyr and Trp.	Asparagine	127-130	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	35-40
10567237-1	1999	The high-affinity interaction of integrin alpha5beta1 with the central cell-binding domain of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the tenth type III repeat) and a second site Pro-His-Ser-Arg-Asn (PHSRN) in the adjacent ninth type III repeat, which synergizes with RGD.	Asparagine	216-219	fibronectin 1	Homo sapiens	94-105
10572095-0	1999	Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a Bbeta Asn-160 to Ser substitution associated with extra glycosylation at Bbeta Asn-158.	Asparagine	90-93	fibrinogen beta chain	Homo sapiens	0-10
10585968-9	1999	The prion domain of Ure2p consists of Asn-rich residues 1 to 80, but two nonoverlapping fragments of the molecule can, when overproduced, induce the de nova appearance of [URE3].	Asparagine	38-41	glutathione peroxidase	Saccharomyces cerevisiae S288C	20-25
10561578-4	1999	An N-glycosylation minus mutant, that was constructed by site-directed mutagenesis (by changing asparagine residues to glutamine and aspartic acid residues at positions 73 and 305 in potential N-glycosylation sites of rat CE) and expressed in normal rat kidney cells, was also purified to homogeneity from the cell extracts.	Asparagine	96-106	cathepsin E	Rattus norvegicus	222-224
10561453-1	1999	The zygomycete fungus Rhizomucor pusillus secretes an aspartic proteinase (MPP) that contains asparagine ( N )-linked oligosaccharides at two sites.	Asparagine	94-104	M-phase phosphoprotein 6	Homo sapiens	75-78
10572126-4	1999	Therefore, we constructed a mutant sec4 allele encoding an amino acid substitution (Ser-28--&gt;Asn) analogous to the Ser-17--&gt;Asn substitution in a trans-dominant inhibitor of mammalian Ras protein.	Asparagine	96-99	Rab family GTPase SEC4	Saccharomyces cerevisiae S288C	35-39
10572126-4	1999	Therefore, we constructed a mutant sec4 allele encoding an amino acid substitution (Ser-28--&gt;Asn) analogous to the Ser-17--&gt;Asn substitution in a trans-dominant inhibitor of mammalian Ras protein.	Asparagine	130-133	Rab family GTPase SEC4	Saccharomyces cerevisiae S288C	35-39
10654085-7	1999	Except for Dip5p, which is a transporter for Glu, Asp, Gln, Asn, Ser, Ala and Gly, the rest of the permeases exhibit narrow specificity.	Asparagine	60-63	Dip5p	Saccharomyces cerevisiae S288C	11-16
10724358-5	1999	Analysis of the CYP21 gene revealed that the patient was a compound heterozygote for the Ile-172--&gt;Asn mutation in exon 4 and the 8-bp deletion in exon 3.	Asparagine	102-105	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	16-21
10585968-10	1999	The prion domain of Sup35 consists of residues 1 to 114, also rich in Asn and Gln residues.	Asparagine	70-73	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	20-25
10822757-9	1999	CONCLUSIONS: Escherichia coli L-asparaginase, binds the plasma membrane in normal human immune cells, catalyzing the L-asparagine substrate.	Asparagine	117-129	asparaginase and isoaspartyl peptidase 1	Homo sapiens	30-44
10684962-7	1999	In addition, the CD23a" and CD23b" molecules in transfected COS cells were resistant to Endo H(f) and PNGase F, although these truncated forms as well as the membrane-associated forms had an asparagine residue responsible for the N-linked glycosylation.	Asparagine	191-201	Fc epsilon receptor II	Homo sapiens	17-22
10514476-8	1999	A double mutation of Asn(682)/Glu(648) caused diminished binding of the beta chain to the MSP receptor, and a single mutation of neighboring Arg(683) completely abolished binding.	Asparagine	21-24	macrophage stimulating 1	Homo sapiens	90-93
11003555-0	1999	Asn-linked sugar chain structures of recombinant human thrombopoietin produced in Chinese hamster ovary cells.	Asparagine	0-3	thrombopoietin	Homo sapiens	55-69
10600006-8	1999	However, CD1d was the restriction element only for those clones with the conservative substitution of threonine or asparagine for serine at the V/J junction.	Asparagine	115-125	CD1d molecule	Homo sapiens	9-13
10563503-1	1999	Kinetic data on the deamidation reaction of Asn67 in RNase A and of Asn3 in the two peptides Ac-Cys-Lys-Asn-Gly-Gln-Thr-Asn-Cys-NH2 and Ac-Cys(Me)-Lys-Asn-Gly-Gln-Thr-Asn-Cys(Me)-NH2, whose sequences are similar to that of the deamidation site in the enzyme, have been determined in a wide range of pH and buffer concentrations.	Asparagine	44-47	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
10515894-2	1999	ABO blood group antigens are covalently associated with asparagine-linked sugar chains of plasma vWF.	Asparagine	56-66	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-15
10515894-2	1999	ABO blood group antigens are covalently associated with asparagine-linked sugar chains of plasma vWF.	Asparagine	56-66	von Willebrand factor	Homo sapiens	97-100
10567703-3	1999	The initially hydrolyzed peptide bonds were detected to be Val(11)-Ala(12) and Leu(19)-Thr(20) (elastase), Phe(78)-Asn(79) (cathepsin G) and Ala(145)-Ser(146) (proteinase 3).	Asparagine	115-118	cathepsin G	Homo sapiens	124-135
10551860-10	1999	The HelB mutant retained about 20% of the cyclooxygenase activity of native oPGHS-1 and partitioned in subcellular fractions like native oPGHS-1; however, the HelB mutant exhibited an extra site of N-glycosylation at Asn(104).	Asparagine	217-220	DNA helicase B	Homo sapiens	4-8
10551860-10	1999	The HelB mutant retained about 20% of the cyclooxygenase activity of native oPGHS-1 and partitioned in subcellular fractions like native oPGHS-1; however, the HelB mutant exhibited an extra site of N-glycosylation at Asn(104).	Asparagine	217-220	DNA helicase B	Homo sapiens	159-163
10687175-1	1999	Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity.	Asparagine	98-108	interleukin 1 beta	Homo sapiens	51-60
10531308-3	1999	The primary structure of this prothoracicostatic peptide (Bom-PTSP) was determined to be H-Ala-Trp-Gln-Asp-Leu-Asn-Ser-Ala-Trp-NH(2).	Asparagine	111-114	prothoracicostatic peptide	Bombyx mori	58-66
10504448-7	1999	In addition two novel mutations within the helix initiation motif of hHb6 were found in Scottish and Portuguese cases, in whom the same highly conserved asparagine residue N114 was mutated to histidine (N114H) or aspartic acid (N114D) residues, respectively.	Asparagine	153-163	keratin 86	Homo sapiens	69-73
10497157-3	1999	By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding.	Asparagine	120-123	ATP binding cassette subfamily C member 8	Rattus norvegicus	30-34
10497157-3	1999	By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding.	Asparagine	120-123	ATP binding cassette subfamily C member 9	Rattus norvegicus	39-43
10571021-2	1999	Each of the two subunits (hCGalpha and hCGbeta) of hCG contain two glycosylated Asn residues.	Asparagine	80-83	glycoprotein hormones, alpha polypeptide	Homo sapiens	26-54
10493937-2	1999	In an attempt to unravel the role of a conserved aspartate (D89) in sheep-liver tetrameric serine hydroxymethyltransferase (SHMT), it was converted into aspargine by site-directed mutagenesis.	Asparagine	153-162	serine hydroxymethyltransferase, cytosolic	Ovis aries	91-122
10493937-2	1999	In an attempt to unravel the role of a conserved aspartate (D89) in sheep-liver tetrameric serine hydroxymethyltransferase (SHMT), it was converted into aspargine by site-directed mutagenesis.	Asparagine	153-162	serine hydroxymethyltransferase, cytosolic	Ovis aries	124-128
10491201-7	1999	Replacement of the His6 residue of alpha-MSH-ND by Gln, Asn, Arg or Lys decreased not only the receptor binding, but also the cAMP-generating activity in both the MC3R and the MC4R.	Asparagine	56-59	melanocortin receptor 3	Cricetulus griseus	163-167
10525356-6	1999	However, the unusual amino acid substitutions found in insulin from P. annectens (e.g., GlyB21 --&gt; Ala, GluB22 --&gt; Asp, and ArgB23 --&gt; Asn) are not present in N. forsteri insulin, suggesting that they occurred in the Protopterus lineage after divergence of the genera.	Asparagine	144-147	insulin	Homo sapiens	55-62
10488113-3	1999	The crystal structure of the mutant of MnSOD containing Asn(30) superimposed closely with the wild type, but the side chain of Asn(30) did not participate in the hydrogen-bonded network in the active site.	Asparagine	56-59	superoxide dismutase 2	Homo sapiens	39-44
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Asparagine	145-148	zona pellucida glycoprotein 2	Mus musculus	68-72
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Asparagine	145-148	zona pellucida glycoprotein 3	Mus musculus	77-81
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Asparagine	123-126	glucokinase	Homo sapiens	84-95
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Asparagine	141-144	glucokinase	Homo sapiens	84-95
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Asparagine	141-144	hexokinase 1	Homo sapiens	199-211
10417409-10	1999	For the 44 confirmed N-glycosylating sequences, an in-depth analysis of the (Psi(N), Phi(X), Psi(X), Phi(S/T)) dihedral angles, which position the side chains of Asn and Ser/Thr, shows that these can be grouped into nine conformational states.	Asparagine	162-165	glucose-6-phosphate isomerase	Homo sapiens	85-88
10499442-1	1999	We recently found that deletion of the Asn-linked carbohydrate (CHO) at residue 197 of Syrian hamster (SHa) PrP(C) while retaining the CHO at Asn 181 has a profound effect on which population of neurons are targeted for conversion of SHaPrP(C) to SHaPrP(Sc) in transgenic (Tg) mice inoculated with scrapie prions.	Asparagine	39-42	major prion protein	Mesocricetus auratus	108-111
10441135-1	1999	Short-time limited peptic hydrolysis of ligand-free human alpha-fetoprotein (AFP) gave two main fragments with molecular masses of 38 and 32 kDa, which had been produced by splitting of the molecule at the position Leu(312)-Asn(313).	Asparagine	224-227	alpha fetoprotein	Homo sapiens	58-75
10441135-1	1999	Short-time limited peptic hydrolysis of ligand-free human alpha-fetoprotein (AFP) gave two main fragments with molecular masses of 38 and 32 kDa, which had been produced by splitting of the molecule at the position Leu(312)-Asn(313).	Asparagine	224-227	alpha fetoprotein	Homo sapiens	77-80
10469296-8	1999	As in human SCCE the P2 position of the propeptide was occupied by an acidic amino acid residue, and the position corresponding to the suggested bottom of the primary substrate specificity pouch occupied by an asparagine residue.	Asparagine	210-220	kallikrein related peptidase 7	Homo sapiens	12-16
10406845-1	1999	Glucosidase I initiates the processing of asparagine (N-) linked glycoproteins by removing the distal alpha1,2-linked glucosyl residue of the tetradecasaccharide Glc(3)Man(9)GlcNAc(2).	Asparagine	42-52	mannosyl-oligosaccharide glucosidase	Homo sapiens	0-13
10400983-1	1999	Alpha-mannosidosis is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the lysosomal alpha-mannosidase, which is involved in the degradation of asparagine-linked carbohydrate cores of glycoproteins.	Asparagine	186-196	mannosidase 2, alpha B1	Mus musculus	117-144
10469826-4	1999	Further optimization can often be achieved by flipping the side chains of asparagine, histidine and glutamine around their chi2, chi2 and chi3 torsion angles, respectively, when this improves the local hydrogen bonding network.	Asparagine	74-84	chitinase 1	Homo sapiens	138-142
10400673-5	1999	Arg-336-Asp-8 and Asn-333-amide interactions were pharmacologically assessed by mutational exchange of Arg-336 and Asn-333 in the receptor or reciprocal elimination of the partner chemical functions in CCK.	Asparagine	18-21	cholecystokinin	Homo sapiens	202-205
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Asparagine	199-202	cholecystokinin A receptor	Homo sapiens	162-168
10400673-0	1999	Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.	Asparagine	17-27	cholecystokinin A receptor	Homo sapiens	45-71
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Asparagine	199-202	cholecystokinin	Homo sapiens	162-165
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Asparagine	324-327	cholecystokinin A receptor	Homo sapiens	162-168
10400673-3	1999	Here we report on the identification of Arg-336 and Asn-333 of CCK-AR, which interact with the Asp-8 carboxylate and the C-terminal amide of CCK-9, respectively.	Asparagine	52-55	cholecystokinin A receptor	Homo sapiens	63-69
10400673-3	1999	Here we report on the identification of Arg-336 and Asn-333 of CCK-AR, which interact with the Asp-8 carboxylate and the C-terminal amide of CCK-9, respectively.	Asparagine	52-55	cholecystokinin	Homo sapiens	63-66
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Asparagine	324-327	cholecystokinin	Homo sapiens	162-165
10403802-2	1999	L-Asparaginase preparation derived from E. coli converts asparagine (Asn) and glutamine (Gln) to aspartate (Asp) and glutamate (Glu), respectively, and causes rapid depletion of Asn and Gln.	Asparagine	57-67	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
10391916-12	1999	LAT-2 exhibits higher affinity (Km = 30-50 microM) to Tyr, Phe, Trp, Thr, Asn, Ile, Cys, Ser, Leu, Val, and Gln and relatively lower affinity (Km = 180-300 microM) to His, Ala, Met, and Gly.	Asparagine	74-77	solute carrier family 7 member 8	Rattus norvegicus	0-5
10403802-2	1999	L-Asparaginase preparation derived from E. coli converts asparagine (Asn) and glutamine (Gln) to aspartate (Asp) and glutamate (Glu), respectively, and causes rapid depletion of Asn and Gln.	Asparagine	69-72	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
10403802-2	1999	L-Asparaginase preparation derived from E. coli converts asparagine (Asn) and glutamine (Gln) to aspartate (Asp) and glutamate (Glu), respectively, and causes rapid depletion of Asn and Gln.	Asparagine	178-181	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
10412802-5	1999	In both patients, we found a Tau gene mutation in exon 10 at codon 279, resulting in an asparagine to lysine substitution (N279K).	Asparagine	88-98	microtubule associated protein tau	Homo sapiens	29-32
10383384-5	1999	Plasmid rescue of both rluA- strains using an rluA gene carrying asparagine or threonine replacements for the highly conserved aspartate 64 demonstrated that neither mutant could form 23 S RNA pseudouridine 746 or tRNA pseudouridine 32 in vivo, showing that this conserved aspartate is essential for enzyme-catalyzed formation of both pseudouridines.	Asparagine	65-75	23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase	Escherichia coli str. K-12 substr. MG1655	23-27
10383384-5	1999	Plasmid rescue of both rluA- strains using an rluA gene carrying asparagine or threonine replacements for the highly conserved aspartate 64 demonstrated that neither mutant could form 23 S RNA pseudouridine 746 or tRNA pseudouridine 32 in vivo, showing that this conserved aspartate is essential for enzyme-catalyzed formation of both pseudouridines.	Asparagine	65-75	23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase	Escherichia coli str. K-12 substr. MG1655	46-50
10383406-12	1999	Biotin-maleimide modification of the mutant PSI complexes indicated that His-595, Trp-622, Leu-628, Tyr-632, and Asn-638 in wild-type PsaB may be exposed on the surface of the PSI complex.	Asparagine	113-116	fatty acid amide hydrolase	Homo sapiens	134-138
10481934-0	1999	A novel frameshift mutation in exon 6 (the site of Asn 291) of the lipoprotein lipase gene in type I hyperlipidemia.	Asparagine	51-54	lipoprotein lipase	Homo sapiens	67-85
10377263-12	1999	The substitution of Arg197 of rat SP-A with Asp or Asn eliminated binding to annexin IV, whereas the substitution of Glu195 with Gln was silent.	Asparagine	51-54	surfactant protein A1	Rattus norvegicus	34-38
10377263-12	1999	The substitution of Arg197 of rat SP-A with Asp or Asn eliminated binding to annexin IV, whereas the substitution of Glu195 with Gln was silent.	Asparagine	51-54	annexin A4	Rattus norvegicus	77-87
10481934-1	1999	A new heterozygous lipoprotein lipase gene defect has been identified in a type I hyperlipidemic patient at the position of notable amino acid Asn 291.	Asparagine	143-146	lipoprotein lipase	Homo sapiens	19-37
10481934-7	1999	DNA analysis of the LPL gene revealed that this patient had a heterozygous one nucleotide deletion of A coding Asn 291, resulting in a premature termination of the LPL protein at amino acid residue 303.	Asparagine	111-114	lipoprotein lipase	Homo sapiens	20-23
10481934-7	1999	DNA analysis of the LPL gene revealed that this patient had a heterozygous one nucleotide deletion of A coding Asn 291, resulting in a premature termination of the LPL protein at amino acid residue 303.	Asparagine	111-114	lipoprotein lipase	Homo sapiens	164-167
10481934-13	1999	These results suggest that MCT, as opposed to LCT, is useful for treatment of type I hyperlipidemia with a novel mutation at the notable amino acid Asn 291 of the LPL gene.	Asparagine	148-151	lipoprotein lipase	Homo sapiens	163-166
10395476-0	1999	Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.	Asparagine	128-138	growth factor receptor bound protein 2	Homo sapiens	98-102
10395476-2	1999	In the present paper, we report the successful replacement of asparagine in this compound by a beta-amino acid mimetic, which brings us closer to our objective of identifying a Grb2-SH2 antagonist suitable for pharmacological investigations.	Asparagine	62-72	growth factor receptor bound protein 2	Homo sapiens	177-181
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	pro-platelet basic protein	Homo sapiens	62-69
10406457-5	1999	Alanine substitutions further demonstrated that lysine 240, asparagine 242, and serine 243 are key residues for AT2-induced apoptosis, ERK inhibition, and SHP-1 activation.	Asparagine	60-70	angiotensin II receptor, type 2	Rattus norvegicus	112-115
10406457-5	1999	Alanine substitutions further demonstrated that lysine 240, asparagine 242, and serine 243 are key residues for AT2-induced apoptosis, ERK inhibition, and SHP-1 activation.	Asparagine	60-70	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	155-160
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	pro-platelet basic protein	Homo sapiens	75-106
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	pro-platelet basic protein	Homo sapiens	108-113
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	pro-platelet basic protein	Homo sapiens	158-165
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	ubiquitin-specific protease YUH1	Saccharomyces cerevisiae S288C	181-185
10419831-2	1999	In the present example, connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) were generated by digestion of a ubiquitin-CTAPIII conjugate with YUH1 and HIV Pr, respectively, as indicated below: [see text] YUH1 cleaved at the peptide bond formed by the C-terminal Gly(76) of ubiquitin (Ub) and the N-terminal Asn(1) of the 85-residue peptide CTAPIII.	Asparagine	346-349	pro-platelet basic protein	Homo sapiens	158-165
10387017-0	1999	Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.	Asparagine	107-117	paired like homeodomain 2	Homo sapiens	46-49
10420985-12	1999	Six cysteins, as well as 5 Asn-linked potential glycosylation sites were evolutionary-conserved, suggesting that this OBCAM subfamily resembles immunoglobulin-like and highly glycosylated molecules.	Asparagine	27-30	opioid binding protein/cell adhesion molecule like	Gallus gallus	118-123
10364201-2	1999	AE1 contains 12-14 transmembrane segments and has a single site of N-glycosylation at Asn-642 in the fourth extracytosolic loop.	Asparagine	86-89	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	0-3
10354514-5	1999	The cDNA that coded for HCAK1 contained a variable region that was derived from O18-O8, showing 96.1% homology to germline, and a Ckappa that had a nucleotide substitution (AGC to AAC), resulting in the 177Ser--&gt;Asn replacement.	Asparagine	215-218	immunoglobulin kappa constant	Homo sapiens	24-29
10353846-7	1999	The substrate interacts with Pro-1, Lys-32, and Ile-64 from one subunit and Tyr-95 and Asn-97 from an adjacent subunit.	Asparagine	87-90	lamin A/C	Homo sapiens	29-34
10356320-5	1999	The asparagine residue at the pTyr+2 position of the Shc-peptide interacted with the main-chain carbonyl groups of Lys109 and Leu120.	Asparagine	4-14	SHC adaptor protein 1	Homo sapiens	53-56
10397153-11	1999	Interestingly, removal of the Ala-Glu-Asn sequence which lies immediately N-terminal from the ITIM in FcR ablated binding to SHP-1 and SHP-2 but not to SHIP.	Asparagine	38-41	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	125-130
10318794-5	1999	To determine which of these two models is correct, we generated two G6PT mutants, T53N and S55N, that created a potential Asn-linked glycosylation site at residues 53-55 (N53SS) or 55-57 (N55QS), respectively.	Asparagine	122-125	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	68-72
10421457-8	1999	Mutants of PON1 containing an asparagine substituted for each of several conserved histidine residues lost hydrolytic activity for each single substitution.	Asparagine	30-40	paraoxonase 1	Homo sapiens	11-15
10339403-6	1999	Furthermore, mutation of the variant residues in UGT2B15 (serine 124, asparagine 125, phenylalanine 165) to the amino acid residues found in UGT2B17 did not alter enzyme activity nor substrate specificity.	Asparagine	70-80	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	49-56
11230806-3	1999	Rainbow trout ARNT(b) (rtARNT(b)) contains a C-terminal domain rich in glutamine and asparagine (QN), whereas the C-terminal domain of rtARNT(a) is rich in proline, serine, and threonine (PST).	Asparagine	85-95	aryl hydrocarbon receptor nuclear translocator	Mus musculus	14-18
10224104-5	1999	Mutation of Gln356 (Gln233 in E. coli MetAP) to alanine results in a catalytic efficiency about one-third that of native with normal substrates but which can cleave methionine from substrates with penultimate histidine, asparagine, glutamine, leucine, methionine, phenylalanine, and tryptophan.	Asparagine	220-230	methionine aminopeptidase	Saccharomyces cerevisiae S288C	38-43
10397153-11	1999	Interestingly, removal of the Ala-Glu-Asn sequence which lies immediately N-terminal from the ITIM in FcR ablated binding to SHP-1 and SHP-2 but not to SHIP.	Asparagine	38-41	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	135-140
10403190-5	1999	TPO-2, an alternatively spliced form of TPO, lacks the essential asparagine (Asn 579).	Asparagine	77-80	thyroid peroxidase	Homo sapiens	40-43
10322122-2	1999	The Asp 187--&gt;Asn (D187N) Asp 187--&gt;Tyr (D187Y) gelsolin mutations facilitate two proteolytic cuts in the parent protein generating a 71-residue fragment that forms amyloid fibrils in humans, putatively causing Finnish type familial amyloidosis (FAF).	Asparagine	17-20	gelsolin	Homo sapiens	54-62
10403190-5	1999	TPO-2, an alternatively spliced form of TPO, lacks the essential asparagine (Asn 579).	Asparagine	65-75	thyroid peroxidase	Homo sapiens	0-3
10403190-5	1999	TPO-2, an alternatively spliced form of TPO, lacks the essential asparagine (Asn 579).	Asparagine	65-75	thyroid peroxidase	Homo sapiens	40-43
10403190-5	1999	TPO-2, an alternatively spliced form of TPO, lacks the essential asparagine (Asn 579).	Asparagine	77-80	thyroid peroxidase	Homo sapiens	0-3
10218949-2	1999	All three asparagine residues (Asn4, Asn176, Asn188) contained within consensus sites for N-linked glycosylation could be glycosylated in Cos-7 cells and appeared to be glycosylated on the endogenous AT1-R in bovine adrenal glomerulosa cells.	Asparagine	10-20	angiotensin II receptor, type 1a	Rattus norvegicus	200-205
10334545-2	1999	CSF asparagine concentration reflects asparaginase systemic pharmacodynamics.	Asparagine	4-14	colony stimulating factor 2	Homo sapiens	0-3
10334545-3	1999	We evaluated the time course of CSF asparagine depletion in children with ALL during and after a course of Escherichia coli asparaginase.	Asparagine	36-46	colony stimulating factor 2	Homo sapiens	32-35
10334545-5	1999	CSF asparagine levels were measured before, during, and after asparaginase dosing.	Asparagine	4-14	colony stimulating factor 2	Homo sapiens	0-3
10334545-7	1999	The proportion of patients with depleted CSF asparagine was higher during asparaginase therapy than at baseline (P &lt; .001), 11 to 30 days (P = .003), and more than 30 days after asparaginase therapy (P &lt; .001).	Asparagine	45-55	colony stimulating factor 2	Homo sapiens	41-44
10334545-8	1999	Median CSF asparagine concentrations were 4.42 micromol/L before, less than 0.04 micromol/L during, and less than 0.04 micromol/L at 1 to 5 days, 1.63 micromol/L at 6 to 10 days, 1.70 micromol/L at 11 to 30 days, and 5.70 micromol/L at more than 30 days after asparaginase therapy, respectively.	Asparagine	11-21	colony stimulating factor 2	Homo sapiens	7-10
10334545-9	1999	CSF depletion was more common in patients with low baseline CSF asparagine concentrations (P = .003).	Asparagine	64-74	colony stimulating factor 2	Homo sapiens	0-3
10334545-9	1999	CSF depletion was more common in patients with low baseline CSF asparagine concentrations (P = .003).	Asparagine	64-74	colony stimulating factor 2	Homo sapiens	60-63
10334545-10	1999	CONCLUSION: CSF asparagine concentrations are depleted by conventional doses of E coli asparaginase in the majority of patients, but they rebound once asparaginase therapy is completed.	Asparagine	16-26	colony stimulating factor 2	Homo sapiens	12-15
10360417-0	1999	Serial lectin affinity chromatography demonstrates altered asparagine-linked sugar-chain structures of prostate-specific antigen in human prostate carcinoma.	Asparagine	59-69	kallikrein related peptidase 3	Homo sapiens	103-128
10372548-3	1999	The substitutions observed in Cw*1507, change codon 77 from AAC (asparagine) to AGC (serine) and codon 80 from AAA (lysine) to AAC (asparagine), compared to Cw*1502.	Asparagine	65-75	glycine-N-acyltransferase	Homo sapiens	60-63
10372548-3	1999	The substitutions observed in Cw*1507, change codon 77 from AAC (asparagine) to AGC (serine) and codon 80 from AAA (lysine) to AAC (asparagine), compared to Cw*1502.	Asparagine	132-142	glycine-N-acyltransferase	Homo sapiens	127-130
10372548-5	1999	Also, the dimorphism at these residues from asparagine and lysine to serine and asparagine, respectively, are known to modulate interaction with the natural killer (NK) cell killer inhibitory receptor (KIR).	Asparagine	44-54	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	202-205
10372548-5	1999	Also, the dimorphism at these residues from asparagine and lysine to serine and asparagine, respectively, are known to modulate interaction with the natural killer (NK) cell killer inhibitory receptor (KIR).	Asparagine	80-90	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	202-205
10360417-1	1999	Differences between prostate carcinoma (PCA) and benign prostatic hyperplasia (BPH) in asparagine (N)-linked sugar-chain structures of prostate-specific antigen (PSA) were investigated using serial lectin affinity chromatography.	Asparagine	87-97	kallikrein related peptidase 3	Homo sapiens	135-166
10187828-6	1999	By reverse transcriptase-polymerase chain reaction and sequence analysis, G to A point mutations were identified in CEM/Mtx-1 transcripts at positions 130 (P1; changes glycine 44 --&gt; arginine) and 380 (P2; changes serine 127 --&gt; asparagine).	Asparagine	235-245	metaxin 1	Homo sapiens	120-125
10329126-7	1999	Likewise, substitution of a cysteine residue for an asparagine residue at position 260 of the cyclin T2a and T2b proteins also resulted in their ability to interact with Tat and stimulate tat-activation in rodent cells.	Asparagine	52-62	cyclin T2	Homo sapiens	94-104
10222643-5	1999	The molecular analysis of the cathodally shifted APOJ*2 allele on IEF gels revealed an amino acid substitution of asparagine by histidine resulting from a missense mutation (A--&gt;C) at codon 317 in exon 7.	Asparagine	114-124	clusterin	Homo sapiens	49-53
10085223-8	1999	5+/-1.6 nM, indicating that the replacement of an Asn residue with Gln decreased the affinity of hENT1 for NBMPR.	Asparagine	50-53	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	97-102
10232403-0	1999	An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis.	Asparagine	3-13	keratin 1	Homo sapiens	60-69
10419027-8	1999	The mutated SHBG is characterized by a point mutation (Asp 327 --&gt; Asn) causing an additional N-glycosylation site, which does not affect the binding of steroids to SHBG.	Asparagine	70-73	sex hormone binding globulin	Homo sapiens	12-16
10068660-4	1999	We found a single silent polymorphism in the nucleotide sequence at the third position of the codon for asparagine at position 167 in the secreted protein (AAC/AAT).	Asparagine	104-114	glycine-N-acyltransferase	Homo sapiens	156-159
10085101-4	1999	Within this region, GIRK2 has an aspartate at position 226, whereas GIRK1 has an asparagine at the equivalent position (217).	Asparagine	81-91	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	68-73
10090732-5	1999	When the T state interface is weakened by Asp --&gt; Asn substitution at a quaternary H-bond (HbK), the Fe-His bond is relaxed and becomes responsive to allosteric effectors.	Asparagine	53-56	hemoglobin subunit mu	Homo sapiens	94-97
10068459-9	1999	Concomitant studies determined structures of oligosaccharides at the three Asn-linked glycosylation sites of MSP.	Asparagine	75-78	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	109-112
10068660-4	1999	We found a single silent polymorphism in the nucleotide sequence at the third position of the codon for asparagine at position 167 in the secreted protein (AAC/AAT).	Asparagine	104-114	serpin family A member 1	Homo sapiens	160-163
10066736-5	1999	By selection in a Na+ ATPase deletion mutant of yeast that shows a high Na+ sensitivity, new HKT1 mutants at positions Gln-270 and Asn-365 were isolated.	Asparagine	131-134	cation transporter HKT1	Triticum aestivum	93-97
10037750-16	1999	The substitution of arginine or asparagine at position 188 reduces hydrogen bonding and destabilizes UMP-GALT.	Asparagine	32-42	galactose-1-phosphate uridylyltransferase	Homo sapiens	105-109
10100855-3	1999	Unexpectedly, we found that the connecting loop in the alpha-1 repeat forms a re-entrant membrane loop with both ends facing the extracellular side and one residue (Asn-125) being accessible from the inside and that the region containing the alpha-2 repeat is mostly accessible from the cytoplasm.	Asparagine	165-168	adrenoceptor alpha 1D	Homo sapiens	55-62
10070056-11	1999	Addition of cycloheximide during ASN and ASN plus EGF treatment completely inhibited ODC activity without affecting the level of ODC protein.	Asparagine	41-44	ornithine decarboxylase 1	Rattus norvegicus	85-88
10070056-0	1999	Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells.	Asparagine	15-25	ornithine decarboxylase 1	Rattus norvegicus	55-78
10091600-6	1999	EGF modules 2, 7 and 8 of the precursor have the consensus sequence for post-translational beta-hydroxylation of Asp/Asn residues.	Asparagine	117-120	epidermal growth factor	Homo sapiens	0-3
10070056-1	1999	Our laboratory has shown that asparagine (ASN) stimulates both ornithine decarboxylase (ODC) activity and gene expression in an intestinal epithelial cell line (IEC-6).	Asparagine	30-40	ornithine decarboxylase 1	Rattus norvegicus	63-86
10070056-1	1999	Our laboratory has shown that asparagine (ASN) stimulates both ornithine decarboxylase (ODC) activity and gene expression in an intestinal epithelial cell line (IEC-6).	Asparagine	30-40	ornithine decarboxylase 1	Rattus norvegicus	88-91
10070056-1	1999	Our laboratory has shown that asparagine (ASN) stimulates both ornithine decarboxylase (ODC) activity and gene expression in an intestinal epithelial cell line (IEC-6).	Asparagine	42-45	ornithine decarboxylase 1	Rattus norvegicus	63-86
10070056-1	1999	Our laboratory has shown that asparagine (ASN) stimulates both ornithine decarboxylase (ODC) activity and gene expression in an intestinal epithelial cell line (IEC-6).	Asparagine	42-45	ornithine decarboxylase 1	Rattus norvegicus	88-91
10070056-4	1999	However, the addition of ASN (10 mM) in the presence of EGF (30 ng/ml) increased the activity of ODC 0.5- to 4-fold over that stimulated by ASN alone.	Asparagine	25-28	epidermal growth factor like 1	Rattus norvegicus	56-59
10070056-4	1999	However, the addition of ASN (10 mM) in the presence of EGF (30 ng/ml) increased the activity of ODC 0.5- to 4-fold over that stimulated by ASN alone.	Asparagine	25-28	ornithine decarboxylase 1	Rattus norvegicus	97-100
10070056-4	1999	However, the addition of ASN (10 mM) in the presence of EGF (30 ng/ml) increased the activity of ODC 0.5- to 4-fold over that stimulated by ASN alone.	Asparagine	140-143	epidermal growth factor like 1	Rattus norvegicus	56-59
10070056-4	1999	However, the addition of ASN (10 mM) in the presence of EGF (30 ng/ml) increased the activity of ODC 0.5- to 4-fold over that stimulated by ASN alone.	Asparagine	140-143	ornithine decarboxylase 1	Rattus norvegicus	97-100
10070056-5	1999	EGF also showed induction of ODC with glutamine and alpha-aminoisobutyric acid, but ODC induction was maximum with ASN and EGF.	Asparagine	115-118	ornithine decarboxylase 1	Rattus norvegicus	84-87
10070056-6	1999	Thus the mechanism of the interaction between ASN and EGF is important for understanding the regulation of ODC under physiological conditions.	Asparagine	46-49	epidermal growth factor like 1	Rattus norvegicus	54-57
10070056-6	1999	Thus the mechanism of the interaction between ASN and EGF is important for understanding the regulation of ODC under physiological conditions.	Asparagine	46-49	ornithine decarboxylase 1	Rattus norvegicus	107-110
10070056-9	1999	The addition of ASN did not further increase the expression of the protooncogenes, but the combination of EGF and ASN further increased the expression of ODC over that of ASN alone.	Asparagine	114-117	ornithine decarboxylase 1	Rattus norvegicus	154-157
10211631-5	1999	RESULTS: Genetic analysis by DNA sequencing detected a three base deletion (AAT) at codon 220 of exon 5, which caused a deletion of one asparagine.	Asparagine	136-146	serpin family A member 1	Homo sapiens	76-79
10319440-6	1999	From these results, models are presented implying that the H-L complex and P25 are associated to form a higher-order complex of specific conformation during the processes of intracellular transport and secretion, and that the Asn-linked glycosylation of P25 is partially altered under such conditions.	Asparagine	226-229	fibrohexamerin	Bombyx mori	75-78
10319440-6	1999	From these results, models are presented implying that the H-L complex and P25 are associated to form a higher-order complex of specific conformation during the processes of intracellular transport and secretion, and that the Asn-linked glycosylation of P25 is partially altered under such conditions.	Asparagine	226-229	fibrohexamerin	Bombyx mori	254-257
10080635-1	1999	Enzymatic properties and asparagine (Asn)-linked sugar-chain structures of N-acetyl beta-D-hexosaminidase A (Hex A) were compared in human tissues between normal renal cortex and renal cell carcinoma (RCC).	Asparagine	25-35	hexosaminidase subunit alpha	Homo sapiens	84-107
10080635-1	1999	Enzymatic properties and asparagine (Asn)-linked sugar-chain structures of N-acetyl beta-D-hexosaminidase A (Hex A) were compared in human tissues between normal renal cortex and renal cell carcinoma (RCC).	Asparagine	25-35	hexosaminidase subunit alpha	Homo sapiens	109-114
10080635-1	1999	Enzymatic properties and asparagine (Asn)-linked sugar-chain structures of N-acetyl beta-D-hexosaminidase A (Hex A) were compared in human tissues between normal renal cortex and renal cell carcinoma (RCC).	Asparagine	37-40	hexosaminidase subunit alpha	Homo sapiens	84-107
10080635-1	1999	Enzymatic properties and asparagine (Asn)-linked sugar-chain structures of N-acetyl beta-D-hexosaminidase A (Hex A) were compared in human tissues between normal renal cortex and renal cell carcinoma (RCC).	Asparagine	37-40	hexosaminidase subunit alpha	Homo sapiens	109-114
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Asparagine	159-162	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10220030-1	1999	Oligosaccharyltransferase (OST) catalyzes the transfer of a branched oligosaccharide from a dolichylpyrophosphate oligosaccharide (Dol-PP-OS) to the asparagine of a nascent polypeptide chain in vivo and peptide substrates in vitro.	Asparagine	149-159	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
10220030-1	1999	Oligosaccharyltransferase (OST) catalyzes the transfer of a branched oligosaccharide from a dolichylpyrophosphate oligosaccharide (Dol-PP-OS) to the asparagine of a nascent polypeptide chain in vivo and peptide substrates in vitro.	Asparagine	149-159	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
10024661-1	1999	Studies in cell lines and malignant human tissues have shown that increased cell-surface Asn-linked beta1-6(GlcNAcbeta1-6Man) branching is associated with increased tumorigenic and metastatic properties.	Asparagine	89-92	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-107
9949732-8	1999	A new TTR variant, Ser23--&gt;Asn, was detected and identified using the above method where isoelectric focusing and restriction enzyme analysis failed to identify the nature of the variant.	Asparagine	30-33	transthyretin	Homo sapiens	6-9
10195448-3	1999	We also synthesized internally quenched fluorescent peptides with the amino acid sequence Phe8-His-Leu-Val-Ile-His-Asn14 of human angiotensinogen, in which [GlcNAcbeta]Asn was introduced before Phe8 and/or after His13 and ortho-aminobenzoic acid (Abz) and N-[2-, 4-dinitrophenyl]-ethylenediamine (EDDnp) were attached at N- and C-terminal ends as a donor/receptor fluorescent pair.	Asparagine	115-118	angiotensinogen	Homo sapiens	130-145
9952443-7	1999	Asparagine at position 65 of Fd II is a unique residue compared with Fd I and other Fds from various plants, which have aspartic acid or glutamic acid at the corresponding position as an electrostatic interaction site with Fd-NADP+ reductase.	Asparagine	0-10	ferredoxin-2, chloroplastic	Zea mays	29-34
9952443-7	1999	Asparagine at position 65 of Fd II is a unique residue compared with Fd I and other Fds from various plants, which have aspartic acid or glutamic acid at the corresponding position as an electrostatic interaction site with Fd-NADP+ reductase.	Asparagine	0-10	fd I	Zea mays	29-33
10021921-1	1999	Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised.	Asparagine	80-83	myelin oligodendrocyte glycoprotein	Homo sapiens	17-21
9895333-1	1999	Hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn --&gt;Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue.	Asparagine	44-47	CD8a molecule	Homo sapiens	31-34
9916684-7	1999	That a posttranslational change in amino acid sequence from Asn to Asp alters the repertoire of peptides presented to CD8+ CTL has implications for the design of antiviral vaccines.	Asparagine	60-63	CD8a molecule	Homo sapiens	118-121
9895333-1	1999	Hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn --&gt;Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue.	Asparagine	159-162	CD8a molecule	Homo sapiens	31-34
10190023-7	1999	Asparagine or aspartic acid has been reported as the major N-terminal amino acid for thyroglobulins of several animal species whereas glutamic acid is the sole N-terminal amino acid for buffalo thyroglobulin.	Asparagine	0-10	thyroglobulin	Homo sapiens	85-98
9867803-3	1999	The carboxyl terminus of Nix, including a transmembrane domain, is highly homologous to Nip3 but it bears a longer and distinct asparagine/proline-rich N terminus.	Asparagine	128-138	BCL2 interacting protein 3 like	Homo sapiens	25-28
9852136-4	1998	We have introduced a mutation (Ser36 --&gt; Asn) into this domain of p190 that decreased its ability to bind guanine nucleotide when expressed as a hemagglutinin (HA)-tagged protein in COS cells.	Asparagine	44-47	contactin associated protein 1	Homo sapiens	69-73
9886097-3	1999	Glycosylation of rds/peripherin at asparagine 229 is widely conserved in vertebrates.	Asparagine	35-45	peripherin 2	Mus musculus	17-31
9860946-5	1998	The Ala and Asn mutants had the same low actin-activated ATPase activity as unphosphorylated wild-type myosin IC.	Asparagine	12-15	myosin IC	Homo sapiens	103-112
9872320-8	1998	We also show that N-glycosylation of asparagine residues blocks AEP action in vitro.	Asparagine	37-47	legumain	Homo sapiens	64-67
9867843-1	1999	UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase I (GnT I) is a key enzyme in the synthesis of Asn-linked complex and hybrid glycans.	Asparagine	132-135	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	89-94
10689617-7	1999	Analyses of the wild type and mutant MRs activities in response to corticosteroids bearing hydroxyl groups at various steroid skeleton position led to the following conclusions: 1) the interaction between the residue Asn 770 and the C21-hydroxyl group of corticosteroids is determinant for stabilizing the active MR conformation and 2) the stability of this conformation is enhanced by the 11-18 hemiketal group of aldosterone whereas it is decreased by the 11 beta- and 17 alpha-hydroxyl groups of cortisol.	Asparagine	217-220	nuclear receptor subfamily 3 group C member 2	Homo sapiens	37-39
9820813-1	1998	The functionality of the C-terminus (Ser-Asn-Leu; SNL) of human d-aspartate oxidase, an enzyme proposed to have a role in the inactivation of synaptically released d-aspartate, as a peroxisome-targeting signal (PTS1) was investigated in vivo and in vitro.	Asparagine	41-44	D-aspartate oxidase	Homo sapiens	64-83
9881061-1	1998	In order to obtain an insight into the mode of binding at the for-Met-Leu-Phe-OH (fMLP) receptor, three fMLP-OMe analogs (1-3) were synthesized in which the Met residue was substituted by Gln 1, Asn 2, and Ser 3.	Asparagine	195-198	formyl peptide receptor 1	Homo sapiens	82-86
9879917-5	1998	The open reading frame of this human DPP cDNA comprises 2364 bp encoding 788 amino acids rich in serine (58%), aspartic acid (26%) and asparagine (9%).	Asparagine	135-145	dentin sialophosphoprotein	Homo sapiens	37-40
9845674-3	1998	The cDNA sequence of leptin is normal in KK mice, whereas three nucleotide polymorphisms were found in the cDNA of the leptin receptor, one of them resulting in exchange of an aspartate residue for asparagine (Asp600Asn) in a highly conserved part of the second extracellular cytokine-receptor homology module.	Asparagine	198-208	leptin	Mus musculus	119-125
9843384-0	1998	Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).	Asparagine	118-121	angiotensin II receptor type 1	Homo sapiens	44-47
9806970-9	1998	However, mutant AMPAR channels, which had an asparagine substituted at the Q/R site, also showed a biionic flux-ratio exponent of 1 and concentration-independent permeability ratios, indicating that the difference in Ca2+ transport is not due to the amino acid residue located at the Q/R/N site.	Asparagine	45-55	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	16-21
9756914-7	1998	The comparison of the NMC-A structure with those of other class A enzymes and enzyme-ligand complexes, indicated that the position of Asn-132 in NMC-A provides critical additional space in the region of the protein where the poorer substrates for class A beta-lactamases, such as cephamycins and carbapenems, need to be accommodated.	Asparagine	134-137	amyloid beta precursor protein	Homo sapiens	253-259
9790975-1	1998	Alignment of amino acids of the region implicated in glucose binding from a series of hexokinases showed that Schizosaccharomyces pombe hexokinase 1 had a Ser residue in a place where all other kinases had an Asn.	Asparagine	209-212	hexokinase 1	Saccharomyces cerevisiae S288C	136-148
9774386-2	1998	We tested the role of processing by creating a mutant in which the P1 residue (Arg3942) of the consensus site for furin cleavage (Arg-Asn-Arg-Arg3942 downward arrow) was replaced with Ser in chicken LRP.	Asparagine	134-137	furin, paired basic amino acid cleaving enzyme	Gallus gallus	114-119
9881155-3	1998	In addition to the previously identified ASN1 gene, we identified a novel class of asparagine synthetase genes in Arabidopsis (ASN2 and ASN3) by functional complementation of a yeast asparagine auxotroph.	Asparagine	83-93	asparagine synthetase 2	Arabidopsis thaliana	127-131
9881155-3	1998	In addition to the previously identified ASN1 gene, we identified a novel class of asparagine synthetase genes in Arabidopsis (ASN2 and ASN3) by functional complementation of a yeast asparagine auxotroph.	Asparagine	83-93	asparagine synthetase 3	Arabidopsis thaliana	136-140
9791008-5	1998	Mutation of the consensus Asp832 of rat ErbB-3 to Asn observed in human and bovine ErbB-3 significantly increased the interaction of ErbB-3 and Syp and PI3K 11 or 26 fold respectively.	Asparagine	50-53	erb-b2 receptor tyrosine kinase 3	Rattus norvegicus	40-46
9791008-5	1998	Mutation of the consensus Asp832 of rat ErbB-3 to Asn observed in human and bovine ErbB-3 significantly increased the interaction of ErbB-3 and Syp and PI3K 11 or 26 fold respectively.	Asparagine	50-53	erb-b2 receptor tyrosine kinase 3	Bos taurus	83-89
9791008-5	1998	Mutation of the consensus Asp832 of rat ErbB-3 to Asn observed in human and bovine ErbB-3 significantly increased the interaction of ErbB-3 and Syp and PI3K 11 or 26 fold respectively.	Asparagine	50-53	erb-b2 receptor tyrosine kinase 3	Bos taurus	83-89
9791008-5	1998	Mutation of the consensus Asp832 of rat ErbB-3 to Asn observed in human and bovine ErbB-3 significantly increased the interaction of ErbB-3 and Syp and PI3K 11 or 26 fold respectively.	Asparagine	50-53	synaptophysin	Bos taurus	144-147
9778359-3	1998	We have previously reported the extracellular orientation of asparagine residues 182, 239, and 298 of the P2X2 receptor subunit by showing that the protein is glycosylated at each site [Torres, G. E., et al.	Asparagine	61-71	purinergic receptor P2X 2	Homo sapiens	106-110
9802612-5	1998	DRB1*15023 differs from DRB1*15021 by a single silent nucleotide substitution (AAC--&gt;AAT, both encoding for Asn) at codon 33.	Asparagine	111-114	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
9770425-2	1998	The natural cleavage of VP2 to VP3 in CPV full (DNA containing) particles recovered from tissue culture occurred within the sequence Arg-Asn-Glu-Arg Ala-Thr.	Asparagine	137-140	VP2	Canine parvovirus	24-27
9735366-5	1998	E(Pc) was cloned by transposon tagging, and encodes a novel 2023 amino acid protein with regions enriched in glutamine, alanine and asparagine.	Asparagine	132-142	Enhancer of Polycomb	Drosophila melanogaster	0-5
9824839-3	1998	It is suggested that sequence-dependent deamidation of asparagine residues in p55, 4.1 and glycophorins C/D could affect the interactions of these junction point proteins in an age-dependent manner.	Asparagine	55-65	MAGUK p55 scaffold protein 1	Homo sapiens	78-107
9824839-4	1998	Comparison of the asparagine content of 4.1 binding regions of p55 analogues dlg and hdlg acts as a caveat to the extrapolation of findings made in erythrocytes to other eukaryotic cells, and has important implications for transmembrane signalling pathways and age-dependent changes in the membrane-binding characteristics of tumour-suppressor proteins in higher cell systems.	Asparagine	18-28	MAGUK p55 scaffold protein 1	Homo sapiens	63-66
9824839-4	1998	Comparison of the asparagine content of 4.1 binding regions of p55 analogues dlg and hdlg acts as a caveat to the extrapolation of findings made in erythrocytes to other eukaryotic cells, and has important implications for transmembrane signalling pathways and age-dependent changes in the membrane-binding characteristics of tumour-suppressor proteins in higher cell systems.	Asparagine	18-28	discs large MAGUK scaffold protein 1	Homo sapiens	85-89
9727001-5	1998	When the lysine residue in guinea pig Kir1.3 (gpKir1.3) isolated from a genomic library was changed to an asparagine (reverse HPS mutation), mutant channels yielded macroscopic currents with amplitudes increased 6-fold.	Asparagine	106-116	inwardly rectifying potassium channel Kir1.3	Cavia porcellus	38-44
9748014-7	1998	Seven kindreds (24%) had previously unreported TTR variants, namely asparagine 35, serine (Ser) 91, phenylalanine (Phe) 77, and Ser 116.	Asparagine	68-78	transthyretin	Homo sapiens	47-50
9748289-2	1998	The oligosaccharyltransferase (OST), which has its active site exposed on the luminal face of the endoplasmic reticulum (ER), catalyzes the transfer of preassembled high mannose oligosaccharides onto certain asparagine residues of nascent polypeptides.	Asparagine	208-218	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	4-29
9748289-2	1998	The oligosaccharyltransferase (OST), which has its active site exposed on the luminal face of the endoplasmic reticulum (ER), catalyzes the transfer of preassembled high mannose oligosaccharides onto certain asparagine residues of nascent polypeptides.	Asparagine	208-218	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	31-34
9820620-6	1998	This mRNA encodes a putative 25 K protein of 219 amino acids in length, having the first 124 amino acids and, thus, two and a half structural alpha-helices in common with hGH-V.hGH-Vdelta4 has lost the N-glycosylation site at Asn 140 of hGH-V, but acquires a novel site at position 148 as well as a cystein-rich domain in the 65 carboxyl-terminal amino acids, potentially involved in multiple disulfide-bridge formation.	Asparagine	226-229	growth hormone 2	Homo sapiens	177-182
9801458-4	1998	The amino acid sequences of insulins from R. catesbeiana and R. ridibunda differ by only one residue (Asp for Glu at B21) but R. sylvatica insulin differs from R. catesbeiana insulin at A12 (Thr--&gt;Met), A23 (Asn--&gt;Ser), B5 (Tyr--&gt;His) and B13 (Glu--&gt;Asp).	Asparagine	211-214	insulin	Homo sapiens	28-35
9861481-11	1998	In codon 234, TAC for tyrosin was mutated to AAC for asparagine by a T to A transversion of the first letter.	Asparagine	53-63	glycine-N-acyltransferase	Homo sapiens	45-48
9725224-3	1998	Here, we examined the role of asparagine-linked carbohydrates of the murine class I MHC in the binding to Ly-49A and Ly-49C.	Asparagine	30-40	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	106-112
9725224-3	1998	Here, we examined the role of asparagine-linked carbohydrates of the murine class I MHC in the binding to Ly-49A and Ly-49C.	Asparagine	30-40	killer cell lectin-like receptor, subfamily A, member 3	Mus musculus	117-123
9802612-5	1998	DRB1*15023 differs from DRB1*15021 by a single silent nucleotide substitution (AAC--&gt;AAT, both encoding for Asn) at codon 33.	Asparagine	111-114	major histocompatibility complex, class II, DR beta 1	Homo sapiens	24-28
9757569-1	1998	A mutant angiotensinogen, S14N, in which Ser14 of ovine angiotensinogen was replaced by Asn to form a N-glycosylation site, was produced in CHO cells.	Asparagine	88-91	angiotensinogen	Cricetulus griseus	9-24
9721102-0	1998	Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.	Asparagine	14-17	epidermal growth factor receptor pathway substrate 15	Homo sapiens	48-53
9670929-3	1998	One soluble KIR2D, derived from an inhibitory receptor with a long cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.	Asparagine	131-141	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	85-92
9716150-1	1998	Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys--&gt;Asn).	Asparagine	159-162	fibrinogen beta chain	Homo sapiens	113-123
9670929-4	1998	Surprisingly, another KIR2D (KIR2DL2), which inhibits NK lysis of cells expressing HLA-C molecules with serine 77 and asparagine 80, bound to HLA-C allotypes carrying either amino acid motif.	Asparagine	118-128	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	29-36
9670929-4	1998	Surprisingly, another KIR2D (KIR2DL2), which inhibits NK lysis of cells expressing HLA-C molecules with serine 77 and asparagine 80, bound to HLA-C allotypes carrying either amino acid motif.	Asparagine	118-128	major histocompatibility complex, class I, C	Homo sapiens	83-88
9698945-7	1998	Gln 182 and Asn 204 as well as Asn 117 and Met 119 are the most likely quenchers, respectively, of the Trp 6 and Trp 113 fluorescence.	Asparagine	12-15	transient receptor potential cation channel subfamily C member 6	Homo sapiens	103-108
9698945-7	1998	Gln 182 and Asn 204 as well as Asn 117 and Met 119 are the most likely quenchers, respectively, of the Trp 6 and Trp 113 fluorescence.	Asparagine	31-34	transient receptor potential cation channel subfamily C member 6	Homo sapiens	103-108
9670929-4	1998	Surprisingly, another KIR2D (KIR2DL2), which inhibits NK lysis of cells expressing HLA-C molecules with serine 77 and asparagine 80, bound to HLA-C allotypes carrying either amino acid motif.	Asparagine	118-128	major histocompatibility complex, class I, C	Homo sapiens	142-147
9670929-3	1998	One soluble KIR2D, derived from an inhibitory receptor with a long cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.	Asparagine	131-141	major histocompatibility complex, class I, C	Homo sapiens	104-109
9632816-8	1998	Two unrelated patients of this group manifesting peroxisome deficiency disorders possessed homozygous, inactivating PEX12 mutations: in one, Arg180Thr by one point mutation, and in the other, deletion of two nucleotides in codons for 291Asn and 292Ser, creating an apparently unchanged codon for Asn and a codon 292 for termination.	Asparagine	237-240	peroxisomal biogenesis factor 12	Homo sapiens	116-121
9720213-0	1998	Asparagine-linked glycosylation of the rat leukemia inhibitory factor expressed by simian COS7 cells.	Asparagine	0-10	LIF, interleukin 6 family cytokine	Rattus norvegicus	43-69
9632798-2	1998	hTRN1 interacts with the M9 region of hnRNP A1, a 38-amino-acid domain rich in Gly, Ser, and Asn, and mediates the nuclear import of M9-bearing proteins in vitro.	Asparagine	93-96	tRNA-Asn (anticodon GTT) 2-7	Homo sapiens	0-5
9712171-9	1998	Based on this finding, we mutated Asp263 in the AT1 receptor to asparagine.	Asparagine	64-74	angiotensin II receptor type 1	Homo sapiens	48-51
9632798-2	1998	hTRN1 interacts with the M9 region of hnRNP A1, a 38-amino-acid domain rich in Gly, Ser, and Asn, and mediates the nuclear import of M9-bearing proteins in vitro.	Asparagine	93-96	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	38-46
9697854-2	1998	The interaction requires all three domains of NSF but occurs between residues Lys-844 and Gln-853 of rat GluR2, with Asn-851 playing a critical role.	Asparagine	117-120	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	46-49
9697854-2	1998	The interaction requires all three domains of NSF but occurs between residues Lys-844 and Gln-853 of rat GluR2, with Asn-851 playing a critical role.	Asparagine	117-120	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	105-110
9601032-7	1998	It is suggested that, by analogy to the GTPase activity of p21(ras) and by examining the crystallographic structure of Spo0F, that the carboxyamide of the mutant Asn 56 may favorably position a catalytic water near the protein acyl phosphate to promote Spo0F approximately P K56N hydrolysis.	Asparagine	162-165	H3 histone pseudogene 16	Homo sapiens	59-62
9632693-2	1998	In vitro expression of the FAF-mutant (Asp187 --&gt; Asn/Tyr) secretory gelsolin in COS cells leads to generation of an aberrant polypeptide presumably representing the precursor for tissue amyloid.	Asparagine	53-56	gelsolin	Homo sapiens	72-80
9696689-0	1998	Synergistic induction of ornithine decarboxylase by asparagine and gut peptides in intestinal crypt cells.	Asparagine	52-62	ornithine decarboxylase 1	Rattus norvegicus	25-48
9696689-1	1998	The objective of this study was to determine whether the amino acid asparagine stimulated the activity of ornithine decarboxylase (ODC) synergistically with epidermal growth factor (EGF) or gastrin in IEC-6 cells, a line of normal rat small intestinal crypt cells.	Asparagine	68-78	ornithine decarboxylase 1	Rattus norvegicus	106-129
9696689-1	1998	The objective of this study was to determine whether the amino acid asparagine stimulated the activity of ornithine decarboxylase (ODC) synergistically with epidermal growth factor (EGF) or gastrin in IEC-6 cells, a line of normal rat small intestinal crypt cells.	Asparagine	68-78	ornithine decarboxylase 1	Rattus norvegicus	131-134
9696689-1	1998	The objective of this study was to determine whether the amino acid asparagine stimulated the activity of ornithine decarboxylase (ODC) synergistically with epidermal growth factor (EGF) or gastrin in IEC-6 cells, a line of normal rat small intestinal crypt cells.	Asparagine	68-78	gastrin	Rattus norvegicus	190-197
9696689-5	1998	Simultaneous addition of asparagine and EGF or gastrin, however, increased ODC activity more than 40-fold.	Asparagine	25-35	ornithine decarboxylase 1	Rattus norvegicus	75-78
9696689-7	1998	Increased ODC activity in cells treated with asparagine and EGF or gastrin was associated with an increase in ODC mRNA and protein levels.	Asparagine	45-55	ornithine decarboxylase 1	Rattus norvegicus	10-13
9696689-7	1998	Increased ODC activity in cells treated with asparagine and EGF or gastrin was associated with an increase in ODC mRNA and protein levels.	Asparagine	45-55	ornithine decarboxylase 1	Rattus norvegicus	110-113
9696689-11	1998	The half-life of mRNA for ODC in unstimulated IEC-6 cells was approximately 30 min and increased to more than 2 h in cells exposed to asparagine, although neither gastrin nor EGF prolonged the stability of ODC mRNA.	Asparagine	134-144	ornithine decarboxylase 1	Rattus norvegicus	26-29
9696689-12	1998	The half-life of mRNA for ODC after combined addition of asparagine and EGF or gastrin was extended to approximately 2 h, similar to asparagine alone.	Asparagine	57-67	ornithine decarboxylase 1	Rattus norvegicus	26-29
9696689-12	1998	The half-life of mRNA for ODC after combined addition of asparagine and EGF or gastrin was extended to approximately 2 h, similar to asparagine alone.	Asparagine	133-143	ornithine decarboxylase 1	Rattus norvegicus	26-29
9696689-14	1998	In conclusion, 1) simultaneous addition of asparagine and EGF or gastrin increases ODC activity in a synergistic manner and 2) asparagine increases ODC mRNA levels through completely distinct mechanisms from EGF or gastrin.	Asparagine	43-53	ornithine decarboxylase 1	Rattus norvegicus	83-86
9696689-14	1998	In conclusion, 1) simultaneous addition of asparagine and EGF or gastrin increases ODC activity in a synergistic manner and 2) asparagine increases ODC mRNA levels through completely distinct mechanisms from EGF or gastrin.	Asparagine	127-137	ornithine decarboxylase 1	Rattus norvegicus	148-151
9643364-2	1998	We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405, Arg 407, Lys 409, Lys 415, and Lys 416) of avian LPL with asparagine.	Asparagine	199-209	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	190-193
9614131-1	1998	Western blots of Xenopus oocyte membrane preparations showed that the apparent molecular mass of the wild type P2X2 receptor (about 65 kDa) was reduced by pretreatment with endoglycosidase H. Mutagenesis of one or more of three potential asparagines (N182S, N239S, and N298S) followed by Western blots showed that each of the sites was glycosylated in the wild type receptor.	Asparagine	238-249	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	111-115
9611168-6	1998	The aat2-2 mutant displays an 80% reduction in levels of aspartate transported in the phloem of light-grown plants, and a 50% reduction in levels of asparagine transported in dark-adapted plants.	Asparagine	149-159	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
9611168-7	1998	These results indicate that cytosolic AAT2 is the major isoenzyme controlling aspartate synthesized for nitrogen transport in the light, and that this aspartate pool is converted to asparagine when plants are dark adapted.	Asparagine	182-192	aspartate aminotransferase 2	Arabidopsis thaliana	38-42
9669555-2	1998	The structure of this site has been constructed by the analysis of low-energy conformers of peptide T, an HIV reproduction inhibitor with amino acid sequence corresponding to the fragment Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr of protein gp120, ensuring the interaction of virus with T4 lymphocytes.	Asparagine	208-211	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	231-236
9593136-7	1998	After cloning of the gene, analysis of the complete nucleotide sequence (1,146 bp) showed that this ampC gene is close to blaCMY-2, from which it differs by three point mutations leading to amino acid substitutions Glu --&gt; Gly at position 22, Trp --&gt; Arg at position 201, and Ser --&gt; Asn at position 343.	Asparagine	293-296	AmpC	Proteus mirabilis	122-130
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Asparagine	173-176	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Asparagine	173-176	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Asparagine	173-176	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Asparagine	173-176	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Asparagine	173-176	H1.0 linker histone	Homo sapiens	120-125
9585360-5	1998	In the SALS patient, the mutation substitutes serine for an asparagine that might be involved in N-linked glycosylation of the EAAT2 protein.	Asparagine	60-70	solute carrier family 1 member 2	Homo sapiens	127-132
9576908-4	1998	Because the His-96 --&gt; Asn substitution of Fhit, which retards ApppA hydrolase activity by seven orders of magnitude, did not block tumor-suppressor activity in vivo, we determined whether this mutation affected ApppA binding or particular steps in the ApppA catalytic cycle.	Asparagine	26-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
9584216-5	1998	Glycine, alanine, valine, leucine, phenylalanine, and asparagine produced constitutive activation in a COS-7 cell expression system (3-5-fold increase in basal cAMP), but glutamate did not, indicating that a negative charge at position 564 may be important for maintaining the inactive LHR conformation.	Asparagine	54-64	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	286-289
9766188-3	1998	Two unrelated individuals with Hb Osler have been recently reinvestigated at the DNA level and surprisingly, in their beta gene, codon 145 was found to be AAT which encodes for asparagine and not for aspartic acid, the aspartate at the protein level resulting, thus, from a very efficient posttranslational event.	Asparagine	177-187	serpin family A member 1	Homo sapiens	155-158
9573211-0	1998	The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.	Asparagine	104-114	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	29-33
9573211-0	1998	The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.	Asparagine	104-114	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	81-85
9573211-2	1998	Using strains with disruptions in the genes for multiple permeases, we demonstrated that Ycc5 (which we have renamed Agp1) is involved in the transport of asparagine and glutamine, performed a kinetic analysis of this activity, and showed that AGP1 expression is subject to nitrogen repression.	Asparagine	155-165	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	89-93
9573211-2	1998	Using strains with disruptions in the genes for multiple permeases, we demonstrated that Ycc5 (which we have renamed Agp1) is involved in the transport of asparagine and glutamine, performed a kinetic analysis of this activity, and showed that AGP1 expression is subject to nitrogen repression.	Asparagine	155-165	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	117-121
9630337-20	1998	Mutation of the human beta3 subunit asparagine to methionine (beta3 N289M found in the equivalent position in Rdl completely inhibited both the GABA-modulatory and GABA-mimetic action of etomidate (10-300 microM) acting at alpha6beta3 N289Mgamma2L receptors.	Asparagine	36-46	LEO1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	110-113
9584221-3	1998	Although asparagine residues in the pore-forming M2 regions of NR1 and NR2 subunits influence Mg2+ block, it has been speculated that additional residues are likely to be involved.	Asparagine	9-19	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	63-66
9692846-1	1998	To improve the efficiency of site-specific conjugation of chelates and drugs to antibodies, and to minimize the incidence of immunoreactivity perturbation to the resultant immunoconjugates, Asn-linked oligosaccharide moieties were designed and engineered into the constant domains of a humanized anti-CD22 monoclonal antibody, hLL2.	Asparagine	190-193	CD22 molecule	Homo sapiens	301-305
9553075-10	1998	The mutation of aspartates 657 and 659 to asparagines in C2B decreased Ca2+-dependent and increased Ca2+-independent vesicle binding, indicating the Ca2+ dependence of the domain is provided by aspartic acid residues in the putative Ca2+-binding pocket.	Asparagine	42-53	secretoglobin family 2B member 3, pseudogene	Homo sapiens	57-60
9650860-0	1998	An asparagine residue regulating conductance through P2X2 receptor/channels.	Asparagine	3-13	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	53-57
9587408-4	1998	Deletion of the carbohydrate moiety by adding tunicamycin during infection of Sf21 cells or mutation of both potential N-glycosylation sites (Asn-4 and Asn-16) abolished the ligand binding of TXA2R, suggesting that N-glycosylation is crucial for binding function.	Asparagine	142-145	thromboxane A2 receptor	Homo sapiens	192-197
9587408-4	1998	Deletion of the carbohydrate moiety by adding tunicamycin during infection of Sf21 cells or mutation of both potential N-glycosylation sites (Asn-4 and Asn-16) abolished the ligand binding of TXA2R, suggesting that N-glycosylation is crucial for binding function.	Asparagine	152-155	thromboxane A2 receptor	Homo sapiens	192-197
9556305-3	1998	All patients carried a mutation of an evolutionarily conserved asparagine residue to a lysine at position 480 (N480K) in the olfactomedin-homology domain, which is encoded by the third exon of the GLC1A gene.	Asparagine	63-73	myocilin	Homo sapiens	197-202
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	Asparagine	183-186	Rho GTPase activating protein 45	Homo sapiens	117-120
9537988-3	1998	We have prepared the site-specific mutant of hMnSOD with the conservative replacement of Gln 143 --&gt; Asn (Q143N).	Asparagine	104-107	superoxide dismutase 2	Homo sapiens	45-51
9537988-10	1998	Also, unlike the wild-type Mn(III)SOD, which is electron paramagnetic resonance (EPR) silent, Q143N MnSOD has a complex EPR spectrum with many resonances in the region below 2250 G. We conclude that the Gln 143 --&gt; Asn mutation has increased the reduction potential of manganese to stabilize Mn(II), indicating that Gln 143 has a substantial role in maintaining a reduction potential favorable for the oxidation and reduction cycles in the catalytic disproportionation of superoxide.	Asparagine	218-221	superoxide dismutase 2	Homo sapiens	100-105
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	Asparagine	183-186	Rho GTPase activating protein 45	Homo sapiens	117-120
9545041-5	1998	Similar results were obtained for two cysteine mutations at asparagine residues of the NR1 and NR2A subunits.	Asparagine	60-70	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	87-90
9512488-4	1998	Additional mutations of NaDC-1 at position 106 showed that aspartic acid and asparagine, but not arginine, can substitute for histidine.	Asparagine	77-87	solute carrier family 13 member 2	Oryctolagus cuniculus	24-30
9545041-5	1998	Similar results were obtained for two cysteine mutations at asparagine residues of the NR1 and NR2A subunits.	Asparagine	60-70	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	95-99
9500786-4	1998	For CD3-delta, we describe a process leading to its degradation that includes trimming of mannose residues from asparagine-linked (N-linked) oligosaccharides, generation of ubiquitinated membrane-bound intermediates, and proteasome-dependent removal from the ER membrane.	Asparagine	112-122	CD3 delta subunit of T-cell receptor complex	Homo sapiens	4-13
9516479-6	1998	Although these recognition sequences possess an Asn residue at +2 relative to the phosphotyrosine and therefore represent potential Grb2 binding sites, phosphopeptide competition and "pull-down" experiments demonstrated that they interact preferentially with the Grb7 versus the Grb2 SH2 domain.	Asparagine	48-51	growth factor receptor bound protein 2	Homo sapiens	132-136
9516479-6	1998	Although these recognition sequences possess an Asn residue at +2 relative to the phosphotyrosine and therefore represent potential Grb2 binding sites, phosphopeptide competition and "pull-down" experiments demonstrated that they interact preferentially with the Grb7 versus the Grb2 SH2 domain.	Asparagine	48-51	growth factor receptor bound protein 7	Homo sapiens	263-267
9516479-6	1998	Although these recognition sequences possess an Asn residue at +2 relative to the phosphotyrosine and therefore represent potential Grb2 binding sites, phosphopeptide competition and "pull-down" experiments demonstrated that they interact preferentially with the Grb7 versus the Grb2 SH2 domain.	Asparagine	48-51	growth factor receptor bound protein 2	Homo sapiens	279-283
9587070-8	1998	Analysis of the LPL gene revealed an Asn 291--&gt;Ser mutation in three patients and a -93 T-G substitution combined with an Asp 9--&gt;Asn mutation in one control subject.	Asparagine	37-40	lipoprotein lipase	Homo sapiens	16-19
9587070-8	1998	Analysis of the LPL gene revealed an Asn 291--&gt;Ser mutation in three patients and a -93 T-G substitution combined with an Asp 9--&gt;Asn mutation in one control subject.	Asparagine	136-139	lipoprotein lipase	Homo sapiens	16-19
9525663-5	1998	The NS3/NS3A proteins have two hydrophobic domains (aa 118 to 141 and 162 to 182) and two potential asparagine-linked glycosylation sites (aa 63 and 150), one of which is located between the hydrophobic domains.	Asparagine	100-110	KRAS proto-oncogene, GTPase	Homo sapiens	4-7
9569179-2	1998	A six nucleotide insert, AATCCC, was found in exon 11 of the vWF gene, predicting the insertion of the amino acids asparagine and proline between phenylalanine 404 and threonine 405 of the vWF propeptide.	Asparagine	115-125	von Willebrand factor	Homo sapiens	61-64
9569179-2	1998	A six nucleotide insert, AATCCC, was found in exon 11 of the vWF gene, predicting the insertion of the amino acids asparagine and proline between phenylalanine 404 and threonine 405 of the vWF propeptide.	Asparagine	115-125	von Willebrand factor	Homo sapiens	189-192
9506972-0	1998	Mutational analysis of the Asn residue essential for RGS protein binding to G-proteins.	Asparagine	27-30	paired like homeodomain 2	Homo sapiens	53-56
9506972-9	1998	Mutational analysis of Asn131 suggests that the stabilization of the G-protein switch regions rather than catalytic action of the Asn residue is a key component for the RGS GAP action.	Asparagine	23-26	paired like homeodomain 2	Homo sapiens	169-172
9559545-1	1998	Human alpha 1-antitrypsin (alpha 1-AT) is a major serine protease inhibitor in plasma, secreted as a glycoprotein with a complex type of carbohydrate at three asparagine residues.	Asparagine	159-169	serpin family A member 1	Homo sapiens	6-25
9539140-3	1998	The results demonstrated that immature rhodopsin binds a single oligosaccharide chain exclusively at Asn-20 in the N-terminal extracellular domain.	Asparagine	101-104	neither inactivation nor afterpotential E	Drosophila melanogaster	39-48
9559545-1	1998	Human alpha 1-antitrypsin (alpha 1-AT) is a major serine protease inhibitor in plasma, secreted as a glycoprotein with a complex type of carbohydrate at three asparagine residues.	Asparagine	159-169	serpin family A member 1	Homo sapiens	27-37
9559545-3	1998	The partial digestion of the recombinant alpha 1-AT with endoglycosidase H and the expression in the mnn9 deletion mutant of S. cerevisiae showed that the recombinant alpha 1-AT secreted in S. cerevisiae was heterogeneous, consisting of molecules containing core carbohydrates on either two or all three asparagine residues.	Asparagine	304-314	serpin family A member 1	Homo sapiens	41-51
9559545-3	1998	The partial digestion of the recombinant alpha 1-AT with endoglycosidase H and the expression in the mnn9 deletion mutant of S. cerevisiae showed that the recombinant alpha 1-AT secreted in S. cerevisiae was heterogeneous, consisting of molecules containing core carbohydrates on either two or all three asparagine residues.	Asparagine	304-314	serpin family A member 1	Homo sapiens	167-177
9482942-4	1998	We show that a single asparagine --&gt; lysine substitution of the rat muscle Na+ channel alpha-subunit, mu1-N434K, renders the channel completely insensitive to 5 microM BTX when expressed in mammalian cells.	Asparagine	22-32	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	78-108
9500442-1	1998	It has recently been suggested that mutation of a conserved tyrosine to asparagine within the ligand-binding domain of the estrogen receptor (ER) alpha confers hormone-independent activation and insensitivity to antiestrogens (Q. X. Zhang et al., Cancer Res., 57: 1244-1249, 1997).	Asparagine	72-82	estrogen receptor 1	Homo sapiens	123-151
9500442-3	1998	As demonstrated previously for ERalpha, we observed that substituting a serine or asparagine but not a phenylalanine for the conserved tyrosine 443 in ERbeta confers constitutive transcriptional activity to the receptor.	Asparagine	82-92	estrogen receptor 1	Homo sapiens	31-38
9500442-5	1998	However, the ligand-independent transcriptional activity of all ERalpha and ERbeta mutants examined, including the tyrosine to asparagine substitutions, was completely abolished by the three antiestrogens tested in this system.	Asparagine	127-137	estrogen receptor 1	Homo sapiens	64-71
9500442-5	1998	However, the ligand-independent transcriptional activity of all ERalpha and ERbeta mutants examined, including the tyrosine to asparagine substitutions, was completely abolished by the three antiestrogens tested in this system.	Asparagine	127-137	estrogen receptor 2	Homo sapiens	76-82
9499091-3	1998	Translation of RNAs in reticulocyte lysates showed that cleavage at the nsP3/nsP4 site occurred efficiently for all mutants except for Glu-nsP4, which was cleaved inefficiently, and Pro-nsP4, which was not detectably cleaved, and that Tyr, Cys, Leu, Arg, and Phe destabilized nsP4 but Ala, Met, Thr, Asn, Gln, and Glu stabilized nsP4 to various extents.	Asparagine	300-303	SH2 domain containing 3C	Homo sapiens	72-76
9498770-4	1998	Mutation of residue D53 to either asparagine (D53N) or valine (D53V) largely abrogated the stabilizing effects of h beta 2m on murine MHC I expression in a predictable manner.	Asparagine	34-44	beta-2 microglobulin	Mus musculus	116-123
9499091-3	1998	Translation of RNAs in reticulocyte lysates showed that cleavage at the nsP3/nsP4 site occurred efficiently for all mutants except for Glu-nsP4, which was cleaved inefficiently, and Pro-nsP4, which was not detectably cleaved, and that Tyr, Cys, Leu, Arg, and Phe destabilized nsP4 but Ala, Met, Thr, Asn, Gln, and Glu stabilized nsP4 to various extents.	Asparagine	300-303	serine protease 57	Homo sapiens	77-81
9480772-2	1998	To obtain insight into the origin of the specificity, the binding to aspartyl-tRNA synthetase (AspRS) of the negatively charged substrate aspartic acid and the neutral analogue asparagine are compared by use of molecular dynamics and free energy simulations.	Asparagine	177-187	aspartyl-tRNA synthetase 1	Homo sapiens	69-93
9521257-1	1998	Fatal familial insomnia (FFI) is an inherited prion disease linked to a mutation at codon 178 of the PRNP gene that results in aspartic acid to asparagine substitution, in coupling phase with methionine at position 129.	Asparagine	144-154	prion protein	Homo sapiens	101-105
9490808-4	1998	We have determined the effects of mutations of two asparagines that line the selectivity filter of the channel, one located within the NR1 subunit (N598) and the other within the NR2A subunit (N596).	Asparagine	51-62	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	135-138
9490808-4	1998	We have determined the effects of mutations of two asparagines that line the selectivity filter of the channel, one located within the NR1 subunit (N598) and the other within the NR2A subunit (N596).	Asparagine	51-62	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	179-183
9490808-8	1998	This suggests that the NR1 asparagine plays a larger role than the NR2 asparagine in controlling the internal Mg2+ block.	Asparagine	27-37	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	23-26
9490808-15	1998	The results suggest that mutations of NR1 and NR2 asparagines lower the central barrier to Mg2+.	Asparagine	50-61	nodal homolog 2 L homeolog	Xenopus laevis	46-49
9490808-16	1998	An additional contribution of the NR2 asparagine to the external Mg2+ binding site (and possibly to the external barrier that controls access to this site) may account for the marked relief of external Mg2+ block produced by the NR2 mutation.	Asparagine	38-48	nodal homolog 2 L homeolog	Xenopus laevis	34-37
9490808-16	1998	An additional contribution of the NR2 asparagine to the external Mg2+ binding site (and possibly to the external barrier that controls access to this site) may account for the marked relief of external Mg2+ block produced by the NR2 mutation.	Asparagine	38-48	nodal homolog 2 L homeolog	Xenopus laevis	229-232
9500211-7	1998	In the p53 gene, an A to C transition was found at the second base of codon 198 (Asn-Thr) in one leukemia, but others had no mutation.	Asparagine	81-84	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	7-10
9544457-0	1998	Genetic variation in human serum albumin: a 313 Lys--&gt;Asn mutation in albumin reading identified by PCR analysis.	Asparagine	57-60	albumin	Homo sapiens	33-40
9544457-0	1998	Genetic variation in human serum albumin: a 313 Lys--&gt;Asn mutation in albumin reading identified by PCR analysis.	Asparagine	57-60	albumin	Homo sapiens	73-80
9512716-12	1998	Mutation of each of Ser38, Ser39 or Lys40 in the BC loop to Ala reduces the affinity of C-SH2 for a cognate phosphopeptide, as does mutation of His93 (BG5) to Asn.	Asparagine	159-162	chorionic somatomammotropin hormone 2	Homo sapiens	88-93
9506848-0	1998	Characterisation of the effects of mutation of the caldesmon sequence 691glu-trp-leu-thr-lys-thr696 to pro-gly-his-tyr-asn-asn on caldesmon-calmodulin interaction.	Asparagine	123-126	calmodulin 2	Gallus gallus	140-150
9480772-2	1998	To obtain insight into the origin of the specificity, the binding to aspartyl-tRNA synthetase (AspRS) of the negatively charged substrate aspartic acid and the neutral analogue asparagine are compared by use of molecular dynamics and free energy simulations.	Asparagine	177-187	aspartyl-tRNA synthetase 1	Homo sapiens	95-100
9480772-3	1998	Simulations of the Asn-AspRS complex show that although Asn cannot bind in the same position as Asp, several possible positions exist 1.5 to 2 A away from the Asp site.	Asparagine	19-22	aspartyl-tRNA synthetase 1	Homo sapiens	23-28
9480772-3	1998	Simulations of the Asn-AspRS complex show that although Asn cannot bind in the same position as Asp, several possible positions exist 1.5 to 2 A away from the Asp site.	Asparagine	56-59	aspartyl-tRNA synthetase 1	Homo sapiens	23-28
9480772-10	1998	This implies that erroneous binding of Asn by AspRS is highly improbable, and cannot account for any errors in the translation of the genetic code.	Asparagine	39-42	aspartyl-tRNA synthetase 1	Homo sapiens	46-51
9679276-0	1998	Synthetic study on a novel Asn-linked core structure: synthesis of a pentasaccharide alpha-D-Man-(1--&gt;3)-[alpha-D-Man-(1--&gt;6)]-beta-D-Man-(1--&gt;4)- [beta-D-GlcNAc-(1--&gt;60]-beta-D-GlcNAc--&gt;OMp.	Asparagine	27-30	olfactory marker protein	Homo sapiens	202-205
9510129-3	1998	However, asparagine 579, which very likely forms a stabilizing hydrogen bond with the proximal histidine in TPO, lies within the missing peptide region.	Asparagine	9-19	thyroid peroxidase	Homo sapiens	108-111
9510129-6	1998	A multiple sequence alignment prepared with five mammalian and five invertebrate peroxidases shows complete conservation of Arg 396, as well as residues corresponding to His 239, His 494, and Asn 579 in TPO.	Asparagine	192-195	thyroid peroxidase	Homo sapiens	203-206
9510129-4	1998	The absence of Asn 579 from TPO-2 may be at least partially responsible for the reported lack of activity of this form of the enzyme.	Asparagine	15-18	thyroid peroxidase	Homo sapiens	28-31
9481670-0	1998	Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.	Asparagine	9-20	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	47-60
9442067-6	1998	The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5.	Asparagine	224-234	prx7	Hordeum vulgare	65-75
9421509-5	1998	A bacterial extract containing the fusion protein catalyzed the aminoacylation reaction of S.cerevisiae tRNA with [14C]asparagine at a 20-fold efficiency level above the control value confirming that this cDNA encodes a human AsnRS.	Asparagine	119-129	asparaginyl-tRNA synthetase 1	Homo sapiens	226-231
9484857-2	1998	The pharmacological profile was studied of MEN 11420, or cyclo[[Asn(beta-D-GlcNAc)-Asp-Trp-Phe-Dap-Leu]cyclo(2beta-5beta )], a glycosylated derivative of the potent, selective, conformationally-constrained tachykinin NK2 receptor antagonist MEN 10627 (cyclo(Met-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta)).	Asparagine	64-67	death associated protein	Homo sapiens	95-98
11062987-6	1998	These results indicate that 32 kDa enamelin has a complex pattern of asparagine-linked glycosylation localized within a small region (20 residues) of the protein.	Asparagine	69-79	enamelin	Homo sapiens	35-43
9421404-0	1998	Substitution of Ala564 in the first zinc cluster of the deoxyribonucleic acid (DNA)-binding domain of the androgen receptor by Asp, Asn, or Leu exerts differential effects on DNA binding.	Asparagine	132-135	androgen receptor	Homo sapiens	106-123
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Asparagine	50-53	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Asparagine	50-53	interleukin 1 beta	Homo sapiens	139-147
9481670-13	1998	In channels containing substitutions of glycine, serine or glutamine for the N-site asparagine in the NR2A-subunit, the block Mg2+ was reduced at negative potentials.	Asparagine	84-94	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	102-106
9481670-16	1998	Equivalent substitutions for the N + 1 site asparagine in the NR2A-subunit strongly attenuated the block over the entire voltage range.	Asparagine	44-54	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	62-66
9481670-19	1998	Channels containing substitutions of the N-site or N + 1 site asparagines in the NR2A-subunit showed an increased Mg2+ permeability suggesting that these adjacent asparagines form a barrier for inward Mg2+ flux.	Asparagine	62-73	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	81-85
9481670-19	1998	Channels containing substitutions of the N-site or N + 1 site asparagines in the NR2A-subunit showed an increased Mg2+ permeability suggesting that these adjacent asparagines form a barrier for inward Mg2+ flux.	Asparagine	163-174	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	81-85
9442031-5	1998	Based on the TSHR primary structure, this small fragment (1-2 kDa) contains Asn-302.	Asparagine	76-79	thyrotropin receptor	Cricetulus griseus	13-17
9469931-8	1998	The NH2-terminus of rb-DNase I was Ala, not Met, and at position 19, corresponding to the carbohydrate attachment site of bp-DNase I, Asn was not glycosylated.	Asparagine	134-137	deoxyribonuclease 1	Bos taurus	125-132
9405276-1	1998	The role of N-linked glycosylation on the biological activity of Schwanniomyces occidentalis SWA2 alpha-amylase, as expressed in Saccharomyces cerevisiae, was analysed by site-directed mutagenesis of the two potential N-glycosylation sites, Asn-134 and Asn-229.	Asparagine	241-244	Swa2p	Saccharomyces cerevisiae S288C	93-97
9405276-1	1998	The role of N-linked glycosylation on the biological activity of Schwanniomyces occidentalis SWA2 alpha-amylase, as expressed in Saccharomyces cerevisiae, was analysed by site-directed mutagenesis of the two potential N-glycosylation sites, Asn-134 and Asn-229.	Asparagine	253-256	Swa2p	Saccharomyces cerevisiae S288C	93-97
9405276-6	1998	alpha-Amylases with substitution at Asn-229 had a 2 kDa lower molecular mass than the wild-type protein, as did the wild-type protein itself after treatment with endoglycosidase F. These findings indicate that Asn-229 is the single glycosylated residue in SWA2.	Asparagine	36-39	Swa2p	Saccharomyces cerevisiae S288C	256-260
9405276-6	1998	alpha-Amylases with substitution at Asn-229 had a 2 kDa lower molecular mass than the wild-type protein, as did the wild-type protein itself after treatment with endoglycosidase F. These findings indicate that Asn-229 is the single glycosylated residue in SWA2.	Asparagine	210-213	Swa2p	Saccharomyces cerevisiae S288C	256-260
9396861-3	1998	The 4D12 mAb bound only to HLA-B*3501 molecules carrying peptides with Asn, Asp, Glu, Ser, and Val at P1.	Asparagine	71-74	major histocompatibility complex, class I, B	Homo sapiens	27-32
9595384-0	1998	Glycosylation of Asn-632 and Asn-651 is important for functional expression of endothelin-converting enzyme-1.	Asparagine	17-20	endothelin converting enzyme 1	Homo sapiens	79-109
9595384-0	1998	Glycosylation of Asn-632 and Asn-651 is important for functional expression of endothelin-converting enzyme-1.	Asparagine	29-32	endothelin converting enzyme 1	Homo sapiens	79-109
9595384-1	1998	It has been shown previously that N-glycosylation of Asn-144 and/or Asn-627 is important for functional expression of neutral endopeptidase-24.11 (NEP).	Asparagine	53-56	membrane metalloendopeptidase	Homo sapiens	118-145
9595384-1	1998	It has been shown previously that N-glycosylation of Asn-144 and/or Asn-627 is important for functional expression of neutral endopeptidase-24.11 (NEP).	Asparagine	53-56	membrane metalloendopeptidase	Homo sapiens	147-150
9595384-1	1998	It has been shown previously that N-glycosylation of Asn-144 and/or Asn-627 is important for functional expression of neutral endopeptidase-24.11 (NEP).	Asparagine	68-71	membrane metalloendopeptidase	Homo sapiens	118-145
9595384-1	1998	It has been shown previously that N-glycosylation of Asn-144 and/or Asn-627 is important for functional expression of neutral endopeptidase-24.11 (NEP).	Asparagine	68-71	membrane metalloendopeptidase	Homo sapiens	147-150
9595384-4	1998	We show that the double mutation of Asn-632 and Asn-651 leads to expression of an enzymatically inactive ECE-1 protein.	Asparagine	36-39	endothelin converting enzyme 1	Homo sapiens	105-110
9595384-4	1998	We show that the double mutation of Asn-632 and Asn-651 leads to expression of an enzymatically inactive ECE-1 protein.	Asparagine	48-51	endothelin converting enzyme 1	Homo sapiens	105-110
9481671-16	1998	The NR2A-subunit N + 1 site asparagine, which together with NR1-subunit N-site asparagine forms the narrow constriction of the channel, also contributed to a blocking site for intracellular Mg2+.	Asparagine	79-89	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	60-63
9481670-22	1998	The adjacent NR2A-subunit asparagines are positioned at or near the narrow constriction of the channel.	Asparagine	26-37	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	13-17
9481670-25	1998	It is concluded that, at the narrow constriction in the NMDA receptor channel, the adjacent NR2A-subunit asparagines, the N-site and N + 1 site, but not the N-site asparagine of the NR1-subunit, form a critical blocking site for extracellular Mg2+.	Asparagine	105-116	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-69
9481670-25	1998	It is concluded that, at the narrow constriction in the NMDA receptor channel, the adjacent NR2A-subunit asparagines, the N-site and N + 1 site, but not the N-site asparagine of the NR1-subunit, form a critical blocking site for extracellular Mg2+.	Asparagine	105-116	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	92-96
9481670-25	1998	It is concluded that, at the narrow constriction in the NMDA receptor channel, the adjacent NR2A-subunit asparagines, the N-site and N + 1 site, but not the N-site asparagine of the NR1-subunit, form a critical blocking site for extracellular Mg2+.	Asparagine	105-115	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-69
9481670-25	1998	It is concluded that, at the narrow constriction in the NMDA receptor channel, the adjacent NR2A-subunit asparagines, the N-site and N + 1 site, but not the N-site asparagine of the NR1-subunit, form a critical blocking site for extracellular Mg2+.	Asparagine	105-115	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	92-96
9481671-10	1998	Substitutions of the N-site asparagine in the NR1-subunit altered intracellular Mg2+ block over physiological membrane potentials (+10 to +50 mV).	Asparagine	28-38	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	46-49
9481671-13	1998	Substitutions of the N-site or N + 1 site asparagine in the NR2A-subunit, which form a blocking site for extracellular Mg2+, also altered the block by intracellular Mg2+.	Asparagine	42-52	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	60-64
9481671-14	1998	However, for the NR2A-subunit N-site asparagine, the block was reduced but only at non-physiological high potentials (&gt; +70 mV).	Asparagine	37-47	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	17-21
9481671-16	1998	The NR2A-subunit N + 1 site asparagine, which together with NR1-subunit N-site asparagine forms the narrow constriction of the channel, also contributed to a blocking site for intracellular Mg2+.	Asparagine	28-38	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	4-8
9481671-16	1998	The NR2A-subunit N + 1 site asparagine, which together with NR1-subunit N-site asparagine forms the narrow constriction of the channel, also contributed to a blocking site for intracellular Mg2+.	Asparagine	28-38	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	60-63
9481671-16	1998	The NR2A-subunit N + 1 site asparagine, which together with NR1-subunit N-site asparagine forms the narrow constriction of the channel, also contributed to a blocking site for intracellular Mg2+.	Asparagine	79-89	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	4-8
9481671-19	1998	It is concluded that intracellular Mg2+ interacts with residues that form the narrow constriction in the NMDA receptor channel with the N-site asparagine of the NR1-subunit representing the dominant blocking site.	Asparagine	143-153	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	161-164
9481670-10	1998	Substitutions of glycine, serine, glutamine or aspartate for the N-site asparagine in the NR1-subunit enhanced the extent of block over intermediate potentials but left the voltage dependence of the block unchanged indicating that structural determinants of the block remained.	Asparagine	72-82	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	90-93
9786161-6	1998	One of the peptides, 1.0 microM of 156Val-Asn-Ser-Thr-Glu-Tyr-Glu-Thr-Ile164 conjugated with BSA, neutralized 26.5% of inhibitor in HB-1"s plasma maximally.	Asparagine	42-45	histocompatibility minor HB-1	Homo sapiens	132-136
9680238-4	1998	Here we report that M2 mutants carrying an asparagine or a threonine residue at the Q-site of GluR1, along with a tryptophan residue at the L-site, form homomeric GluR1 channels that are highly sensitive to structurally diverse, uncompetitive NMDA antagonists such as arylcyclohexylamines, dibenzocycloheptenimines, and to morphinian and adamantane derivatives.	Asparagine	43-53	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	94-99
9680238-4	1998	Here we report that M2 mutants carrying an asparagine or a threonine residue at the Q-site of GluR1, along with a tryptophan residue at the L-site, form homomeric GluR1 channels that are highly sensitive to structurally diverse, uncompetitive NMDA antagonists such as arylcyclohexylamines, dibenzocycloheptenimines, and to morphinian and adamantane derivatives.	Asparagine	43-53	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	163-168
9769701-4	1998	Previous studies demonstrated that mutation of a conserved aspartate residue in the alpha 2AAR to asparagine (D79N alpha 2AAR) resulted in a receptor that retained its ability to inhibit voltage-gated Ca2+ channels and cAMP production but was unable to activate K+ currents in AtT20 cells (Surprenant et al., 1992).	Asparagine	98-108	adrenergic receptor, alpha 2a	Mus musculus	84-94
9769701-4	1998	Previous studies demonstrated that mutation of a conserved aspartate residue in the alpha 2AAR to asparagine (D79N alpha 2AAR) resulted in a receptor that retained its ability to inhibit voltage-gated Ca2+ channels and cAMP production but was unable to activate K+ currents in AtT20 cells (Surprenant et al., 1992).	Asparagine	98-108	adrenergic receptor, alpha 2a	Mus musculus	115-125
10322749-3	1998	RESULTS: Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.	Asparagine	293-303	calsyntenin 2	Rattus norvegicus	36-39
9459510-4	1998	Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80.	Asparagine	13-16	major histocompatibility complex, class I, C	Homo sapiens	80-85
9459510-4	1998	Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80.	Asparagine	32-35	major histocompatibility complex, class I, C	Homo sapiens	80-85
9459510-4	1998	Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80.	Asparagine	32-35	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	116-119
10322749-3	1998	RESULTS: Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.	Asparagine	377-387	calsyntenin 2	Rattus norvegicus	36-39
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Asparagine	149-152	N-methylpurine DNA glycosylase	Homo sapiens	135-138
9388263-0	1997	Critical role of asparagine 1065 of human alpha2-macroglobulin in formation and reactivity of the thiol ester.	Asparagine	17-27	alpha-2-macroglobulin	Homo sapiens	42-62
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	123-133	alpha-2-macroglobulin	Homo sapiens	91-111
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	123-133	alpha-2-macroglobulin	Homo sapiens	113-120
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	123-133	alpha-2-macroglobulin	Homo sapiens	203-210
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	234-244	alpha-2-macroglobulin	Homo sapiens	91-111
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	234-244	alpha-2-macroglobulin	Homo sapiens	113-120
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Asparagine	234-244	alpha-2-macroglobulin	Homo sapiens	203-210
9398187-1	1997	The carboxamide moiety that links the carbohydrate and protein moieties in N-linked glycoproteins has been unambiguously determined to arise intact from asparagine by the use of chemically synthesized Bz-[4-13C, 15N]Asn-Leu-Thr-NH2 as an oligosaccharyltransferase (OST) substrate.	Asparagine	153-163	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	238-263
9398187-1	1997	The carboxamide moiety that links the carbohydrate and protein moieties in N-linked glycoproteins has been unambiguously determined to arise intact from asparagine by the use of chemically synthesized Bz-[4-13C, 15N]Asn-Leu-Thr-NH2 as an oligosaccharyltransferase (OST) substrate.	Asparagine	153-163	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	265-268
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Asparagine	176-179	N-methylpurine DNA glycosylase	Homo sapiens	135-138
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Asparagine	176-179	serpin family A member 1	Homo sapiens	154-157
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Asparagine	149-152	serpin family A member 1	Homo sapiens	154-157
18642238-3	1997	In batch cultures, decreased sialylation was observed at each of the glycosylation sites (i.e., Asn(25) and Asn(97)) of IFN-gamma with the use of elevated concentrations of the peptone.	Asparagine	96-99	interferon gamma	Cricetulus griseus	120-129
9428692-3	1997	We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor.	Asparagine	187-197	signal transducer and activator of transcription 5B	Homo sapiens	33-40
9428692-3	1997	We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor.	Asparagine	187-197	insulin	Homo sapiens	80-87
9428692-3	1997	We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor.	Asparagine	187-197	insulin	Homo sapiens	115-122
9648264-0	1997	Enzyme-assisted synthesis of Asn-linked diantennary oligosaccharides occurring on glycodelin A.	Asparagine	29-32	progestagen associated endometrial protein	Homo sapiens	82-94
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Asparagine	130-133	MLO-like protein 4	Zea mays	73-104
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Asparagine	130-133	MLO-like protein 4	Zea mays	106-110
18642238-3	1997	In batch cultures, decreased sialylation was observed at each of the glycosylation sites (i.e., Asn(25) and Asn(97)) of IFN-gamma with the use of elevated concentrations of the peptone.	Asparagine	108-111	interferon gamma	Cricetulus griseus	120-129
9367524-5	1997	Using site-directed mutagenesis on the gene coding for yeast MetAP1, we replaced Asp219 (corresponding to Asp97 in E. coli MetAP) with Asn.	Asparagine	135-138	methionine aminopeptidase	Saccharomyces cerevisiae S288C	61-66
9395074-1	1997	In order to mimic regulatory phosphorylation of the Ser-15 of maize C4-form phosphoenolpyruvate carboxylase (PEPC), we replaced Ser-15 and Lys-12 with Asp (S15D) and Asn (K12N), respectively, by site-directed mutagenesis.	Asparagine	166-169	MLO-like protein 4	Zea mays	109-113
9388468-2	1997	The GPR1 gene encodes 961 amino acids with predicted seven transmembrane segments and two large cytosolic regions as third cytosolic loop with 350 amino acids where asparagine-rich region was found and the C-terminal region with 283 amino acids.	Asparagine	165-175	Gpr1p	Saccharomyces cerevisiae S288C	4-8
9369469-0	1997	Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --&gt; asparagine mutant.	Asparagine	119-129	thioredoxin	Homo sapiens	6-17
9395789-0	1997	The Asn-291--&gt;Ser and Ser-477--&gt;Stop mutations of the lipoprotein lipase gene and their significance for lipid metabolism in patients with hypertriglyceridaemia.	Asparagine	4-7	lipoprotein lipase	Homo sapiens	60-78
9367678-2	1997	4.1.119) (DDOST) catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto the asparagine acceptor site within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains across the membrane of the endoplasmic reticulum.	Asparagine	175-185	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	10-15
9402049-1	1997	We have characterized the action of the novel, water-soluble, tachykinin NK2 receptor antagonist MEN 11420 ([Asn(2-AcNH-beta-D-Glc)-Asp-Trp-Phe-Dap-Leu] c(2 beta-5 beta)) on the circular muscle of the guinea-pig and human colon in vitro and on the guinea-pig colon in vivo.	Asparagine	109-112	tachykinin receptor 2	Homo sapiens	73-76
9360555-5	1997	Analysis of the genomic DNA of the child"s peripheral leukocytes showed a G to A base exchange that led to a heterozygous Ser to Asn conversion at position 505 in the third transmembrane region of the TSH receptor (TSHR).	Asparagine	129-132	thyroid stimulating hormone receptor	Homo sapiens	201-213
9349532-3	1997	Previous studies have indicated that alpha-thrombin and SFLLRN (synthetic hexapeptide sequence of serine, phenylalanine, leucine, leucine, arginine, asparagine; the human thrombin receptor "tethered ligand") induce neurite retraction and neurotoxicity.	Asparagine	149-159	coagulation factor II (thrombin) receptor	Rattus norvegicus	171-188
9369418-2	1997	Deprivation of L-asparagine from the culture of L5178Y cells by L-asparaginase caused the fragmentation of chromosomal DNA of the leukemia cells within 24 h. Prior to the degradation of DNA, cell cycles of L5178Y cells were found to be arrested in G1 phase, and evidence of the DNA strand breaks was initially observed in G1 phase cells as early as 8 h after the asparaginase treatment.	Asparagine	15-27	asparaginase like 1	Mus musculus	64-78
9402049-1	1997	We have characterized the action of the novel, water-soluble, tachykinin NK2 receptor antagonist MEN 11420 ([Asn(2-AcNH-beta-D-Glc)-Asp-Trp-Phe-Dap-Leu] c(2 beta-5 beta)) on the circular muscle of the guinea-pig and human colon in vitro and on the guinea-pig colon in vivo.	Asparagine	109-112	death associated protein	Homo sapiens	144-147
9373138-6	1997	Not45 shows significant homology to yeast ALG3 protein acting as a dolichol mannosyltransferase in the asparagine-linked glycosylation.	Asparagine	103-113	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	42-46
9346936-3	1997	Preparation of recombinant rat Bcl-xL yielded two forms, one deamidated at -Asn-Gly- sequences to produce isoaspartates and the other not deamidated.	Asparagine	76-79	Bcl2-like 1	Rattus norvegicus	31-37
9370036-0	1997	Solid-phase synthesis of CD52 glycopeptide and an efficient route to Asn-core pentasaccharide conjugate.	Asparagine	69-72	CD52 molecule	Homo sapiens	25-29
9354764-2	1997	Herein we show that patients with the Asn-187 gelsolin mutation have, in addition to full-sized gelsolin, a series of lower-Mr C-terminal fragments of gelsolin (Mr of 70,000-45,000) in the circulation, and that a 50 to 55-kd fragment of gelsolin is excreted in the urine.	Asparagine	38-41	gelsolin	Homo sapiens	46-54
21528263-6	1997	An A to G nucleotide substitution giving rise to an amino acid substitution (Asn--&gt;Asp) in codon 21 at the first potential N-glycosylation site of the P-glycoprotein was seen in primary tumors from four patients and in an axillar lymph node metastases from one of these patients.	Asparagine	77-80	ATP binding cassette subfamily B member 1	Homo sapiens	154-168
9342405-7	1997	An outstanding feature of Mss11p is that the protein contains regions of 33 asparagine residues interrupted by only three serine residues, and 35 glutamine residues interrupted by a single histidine residue.	Asparagine	76-86	Mss11p	Saccharomyces cerevisiae S288C	26-32
9322498-7	1997	Mutational screening identified a single A to T mutation resulting in an asparagine to isoleucine transition mutation at position 21 (N21I) in cationic trypsinogen.	Asparagine	73-83	serine protease 1	Homo sapiens	143-163
9354764-2	1997	Herein we show that patients with the Asn-187 gelsolin mutation have, in addition to full-sized gelsolin, a series of lower-Mr C-terminal fragments of gelsolin (Mr of 70,000-45,000) in the circulation, and that a 50 to 55-kd fragment of gelsolin is excreted in the urine.	Asparagine	38-41	gelsolin	Homo sapiens	96-104
9354764-2	1997	Herein we show that patients with the Asn-187 gelsolin mutation have, in addition to full-sized gelsolin, a series of lower-Mr C-terminal fragments of gelsolin (Mr of 70,000-45,000) in the circulation, and that a 50 to 55-kd fragment of gelsolin is excreted in the urine.	Asparagine	38-41	gelsolin	Homo sapiens	96-104
9354764-2	1997	Herein we show that patients with the Asn-187 gelsolin mutation have, in addition to full-sized gelsolin, a series of lower-Mr C-terminal fragments of gelsolin (Mr of 70,000-45,000) in the circulation, and that a 50 to 55-kd fragment of gelsolin is excreted in the urine.	Asparagine	38-41	gelsolin	Homo sapiens	96-104
9354764-4	1997	In patients heterozygous for the Asn-187 mutation--the usual form of the expression of the dominant disease--normal-sized gelsolin is the major circulating form; the 65- and 55-kd fragments represent minor components.	Asparagine	33-36	gelsolin	Homo sapiens	122-130
9305963-7	1997	The proposed PNP TS also entails a hydrogen bond between N7 and a highly conserved Asn.	Asparagine	83-86	purine nucleoside phosphorylase	Homo sapiens	13-16
9287334-1	1997	Vitamin K-dependent protein S, a cofactor of the anticoagulant enzyme-activated protein C, has four epidermal growth factor (EGF)-like modules, all of which have one partially hydroxylated Asp (EGF 1; beta-hydroxyaspartic acid) or Asn (EGF 2, 3, and 4; beta-hydroxyasparagine) residue.	Asparagine	231-234	protein S	Homo sapiens	0-29
9380754-7	1997	The mutation of an amino acid (Asn-289) present within the channel domain of the beta3 subunit to Ser (the homologous residue in beta1), strongly suppressed the GABA-modulatory and GABA-mimetic effects of etomidate.	Asparagine	31-34	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	129-134
9378548-1	1997	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-6 fucosyltransferase (alpha1-6FucT) catalyzes the transfer of a fucosyl residue from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1-6 linkage.	Asparagine	150-160	fucosyltransferase 8	Homo sapiens	0-67
9378548-1	1997	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-6 fucosyltransferase (alpha1-6FucT) catalyzes the transfer of a fucosyl residue from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1-6 linkage.	Asparagine	150-160	fucosyltransferase 8	Homo sapiens	69-81
9378548-1	1997	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-6 fucosyltransferase (alpha1-6FucT) catalyzes the transfer of a fucosyl residue from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1-6 linkage.	Asparagine	150-160	adrenoceptor alpha 1D	Homo sapiens	40-48
9268623-3	1997	Lungfish insulin contains unusual structural features, such as the dipeptide extension to the C-terminus of the A-chain and the substitution Arg --&gt; Asn at position B-23 in the putative receptor binding region of insulin, which may be expected to influence appreciably its biological potency relative to mammalian insulins.	Asparagine	152-155	insulin	Homo sapiens	9-16
9281591-4	1997	Mutational studies reveal that Asn and Tyr of the NPXY motif and a Val residue located NH2-terminal to this motif are critical for the ICAP-1 binding.	Asparagine	31-34	integrin subunit beta 1 binding protein 1	Homo sapiens	135-141
9291097-9	1997	In addition, cm1, cm2, cm3, chs and cht ascorbate peroxidases contain Asp-43, Asn-57 and Ser-59, indicative of a distal monovalent cation site.	Asparagine	78-81	chorismate mutase 1	Arabidopsis thaliana	13-16
9291097-9	1997	In addition, cm1, cm2, cm3, chs and cht ascorbate peroxidases contain Asp-43, Asn-57 and Ser-59, indicative of a distal monovalent cation site.	Asparagine	78-81	chorismate mutase 3	Arabidopsis thaliana	23-26
9268623-3	1997	Lungfish insulin contains unusual structural features, such as the dipeptide extension to the C-terminus of the A-chain and the substitution Arg --&gt; Asn at position B-23 in the putative receptor binding region of insulin, which may be expected to influence appreciably its biological potency relative to mammalian insulins.	Asparagine	152-155	insulin	Homo sapiens	216-223
9287001-6	1997	When a conserved lysine residue at position 42 that is involved in ATP binding was replaced with asparagine in both MalK subunits, maltose transport and ATPase activities were reduced to 1% of those of the wild type.	Asparagine	97-107	ATPase	Escherichia coli	153-159
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	0-10	Rac family small GTPase 1	Mus musculus	54-58
9307964-7	1997	In flight muscle, there is only one GPDH isoform, GPDH-1, which is distinguished from isoforms found in other tissues by having three C-terminal amino acids: glutamine, asparagine, and leucine.	Asparagine	169-179	Glycerol-3-phosphate dehydrogenase 1	Drosophila melanogaster	36-40
9307964-7	1997	In flight muscle, there is only one GPDH isoform, GPDH-1, which is distinguished from isoforms found in other tissues by having three C-terminal amino acids: glutamine, asparagine, and leucine.	Asparagine	169-179	Glycerol-3-phosphate dehydrogenase 1	Drosophila melanogaster	50-56
9342709-2	1997	Asn at position 4 conserved among all mammalian metallothionein-1 and metallothionein-2 is replaced by Asp in the canine metallothionein cDNA clone.	Asparagine	0-3	metallothionein-1	Canis lupus familiaris	48-65
9342709-2	1997	Asn at position 4 conserved among all mammalian metallothionein-1 and metallothionein-2 is replaced by Asp in the canine metallothionein cDNA clone.	Asparagine	0-3	metallothionein 2A	Homo sapiens	70-87
9342709-2	1997	Asn at position 4 conserved among all mammalian metallothionein-1 and metallothionein-2 is replaced by Asp in the canine metallothionein cDNA clone.	Asparagine	0-3	transcription initiation factor TFIID subunit 4	Canis lupus familiaris	48-63
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Asparagine	193-203	growth factor receptor bound protein 2	Homo sapiens	56-60
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Asparagine	193-203	SHC adaptor protein 1	Homo sapiens	65-68
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Asparagine	193-203	growth factor receptor bound protein 2	Homo sapiens	56-64
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	0-10	guanine nucleotide binding protein, alpha 12	Mus musculus	151-160
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	0-10	guanine nucleotide binding protein, alpha 12	Mus musculus	162-171
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	15-18	Rac family small GTPase 1	Mus musculus	54-58
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	15-18	guanine nucleotide binding protein, alpha 12	Mus musculus	151-160
9264413-3	1997	Asparagine 17 (Asn 17) dominant inhibitory mutants of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of G alpha12 (G alpha12 Leu 229) in NIH3T3 cells.	Asparagine	15-18	guanine nucleotide binding protein, alpha 12	Mus musculus	162-171
9288928-6	1997	Arg505 in COT, conserved in all reported carnitine acyltransferase sequences but replaced by asparagine or isoleucine in the choline acetyltransferases, was converted to asparagine by site-directed mutagenesis.	Asparagine	93-103	carnitine O-octanoyltransferase	Bos taurus	10-13
9288928-6	1997	Arg505 in COT, conserved in all reported carnitine acyltransferase sequences but replaced by asparagine or isoleucine in the choline acetyltransferases, was converted to asparagine by site-directed mutagenesis.	Asparagine	170-180	carnitine O-octanoyltransferase	Bos taurus	10-13
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	20-23
9300882-0	1997	Serial lectin affinity chromatography with concavalin A and wheat germ agglutinin demonstrates altered asparagine-linked sugar-chain structures of prostatic acid phosphatase in human prostate carcinoma.	Asparagine	103-113	acid phosphatase 3	Homo sapiens	147-173
9300882-1	1997	Differences between human prostate carcinoma (PCA, five cases) and benign prostatic hyperplasia (BPH, five cases) in asparagine-linked (Asn) sugar-chain structure of prostatic acid phosphatase (PAP) were investigated using lectin affinity chromatography with concanavalin A (Con A) and wheat germ agglutinin (WGA).	Asparagine	117-127	acid phosphatase 3	Homo sapiens	166-192
9300882-1	1997	Differences between human prostate carcinoma (PCA, five cases) and benign prostatic hyperplasia (BPH, five cases) in asparagine-linked (Asn) sugar-chain structure of prostatic acid phosphatase (PAP) were investigated using lectin affinity chromatography with concanavalin A (Con A) and wheat germ agglutinin (WGA).	Asparagine	136-139	acid phosphatase 3	Homo sapiens	166-192
9278251-0	1997	Glycosylation of asparagine 24 of the natriuretic peptide receptor-B is crucial for the formation of a competent ligand binding domain.	Asparagine	17-27	natriuretic peptide receptor 2	Homo sapiens	38-68
9278251-8	1997	Our results indicate that glycosylation of asparagine 24 of NPR-B receptors may be critical for the formation of a competent ligand binding domain.	Asparagine	43-53	natriuretic peptide receptor 2	Homo sapiens	60-65
9257709-3	1997	For the hydrolysis of L-asparagine the Km is 3-4-fold higher and Vmax 1/5 of that for glycoasparagines suggesting that the full catalytic potential of glycosylasparaginase is not used in the hydrolysis of the free amino acid.	Asparagine	22-34	aspartylglucosaminidase	Homo sapiens	151-171
9223414-4	1997	After sequencing different regions of the env gene including V1-V2, V3, and the fusion domain of both viruses, we have found only an asparagine (N)-to-isoleucine (I) change in position 7 of the V3 loop.	Asparagine	133-143	endogenous retrovirus group W member 1, envelope	Homo sapiens	42-45
18636497-3	1997	Sialylation profiles were quantitated by reversed-phase HPLC separations of the site-specific pools of tryptic glycopeptides representing IFN-gamma"s two potential N-linked glycosylation sites (i.e., Asn(25) and Asn(97)).	Asparagine	200-203	interferon gamma	Homo sapiens	138-147
18636497-3	1997	Sialylation profiles were quantitated by reversed-phase HPLC separations of the site-specific pools of tryptic glycopeptides representing IFN-gamma"s two potential N-linked glycosylation sites (i.e., Asn(25) and Asn(97)).	Asparagine	212-215	interferon gamma	Homo sapiens	138-147
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	101-104
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	101-104
9202037-6	1997	Site-directed mutagenesis on IRS-1 583-693 shows that the asparagine, but not the tyrosine residue of the N625GDY628motif domain, is implicated in the IRS-1-Shc-phosphotyrosine binding interaction.	Asparagine	58-68	insulin receptor substrate 1	Homo sapiens	29-34
9202037-6	1997	Site-directed mutagenesis on IRS-1 583-693 shows that the asparagine, but not the tyrosine residue of the N625GDY628motif domain, is implicated in the IRS-1-Shc-phosphotyrosine binding interaction.	Asparagine	58-68	insulin receptor substrate 1	Homo sapiens	151-156
9202037-6	1997	Site-directed mutagenesis on IRS-1 583-693 shows that the asparagine, but not the tyrosine residue of the N625GDY628motif domain, is implicated in the IRS-1-Shc-phosphotyrosine binding interaction.	Asparagine	58-68	SHC adaptor protein 1	Homo sapiens	157-160
9410120-10	1997	There were significant decreases of CD4 molecules in the following groups: whole population, ASN, CRS, more than 500 (initially), between 500 and 200 (initially), the mean number of T4 lymphocytes was 140/mm3 in progressors versus 358 in non-progressors (p &lt; 0.05).	Asparagine	93-96	CD4 molecule	Homo sapiens	36-39
9188526-3	1997	Nuclear injection of a Ran mutant (Thr24 --&gt; Asn) blocked protein export but not import, whereas depletion of the Ran nucleotide exchange factor RCC1 blocked protein import but not export.	Asparagine	48-51	RAN, member RAS oncogene family	Homo sapiens	23-26
9237811-7	1997	Substitutions Asp --&gt; Asn, Asp --&gt; Lys, Asp --&gt; Leu, show a correlation between diminished affinity for IL-2 receptor and reduced bioactivity measured on TS1beta cells.	Asparagine	25-28	interleukin 2 receptor subunit beta	Homo sapiens	113-126
9266477-1	1997	The structure of neuromedin C, a 10-residue bombesin-like neuropeptide with the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, has been investigated.	Asparagine	93-96	gastrin releasing peptide	Homo sapiens	17-29
9354368-15	1997	Since the Asn residue in the CRD (carbohydrate recognition domain), which is conserved in all other galectins, is substituted by Ser in the case of Nh, these data suggest that the two CRDs in this tandem-repeat galectin have different sugar binding properties and that the 32-kDa galectin may serve as a heterobifunctional crosslinker.	Asparagine	10-13	Galectin	Caenorhabditis elegans	100-108
9354368-15	1997	Since the Asn residue in the CRD (carbohydrate recognition domain), which is conserved in all other galectins, is substituted by Ser in the case of Nh, these data suggest that the two CRDs in this tandem-repeat galectin have different sugar binding properties and that the 32-kDa galectin may serve as a heterobifunctional crosslinker.	Asparagine	10-13	Galectin	Caenorhabditis elegans	211-219
9193431-4	1997	We previously demonstrated that two amino acid substitutions in LPL, the Asn291-Ser and the Asp9-Asn, are associated with elevated triglycerides and lower HDL cholesterol and are present with greater frequency in coronary artery disease (CAD) patients than in normolipidemic control subjects.	Asparagine	73-76	lipoprotein lipase	Homo sapiens	64-67
9182541-1	1997	The galactose-H+ symport protein (GalP) of Escherichia coli is very similar to the human glucose transport protein, GLUT1, and both contain a highly conserved Asn residue in predicted helix 11 that is different in a cytochalasin B-resistant member of this sugar transport family (XylE).	Asparagine	159-162	solute carrier family 2 member 1	Homo sapiens	116-121
9177202-5	1997	We examined the reactivity of Di-OVA to PNGase HO and found that this enzyme site-specifically cleaved off the glycan chain at Asn-311 to convert Di-OVA into the mono-N-glycosylated form (CHO-Asn-292/Asp-311).	Asparagine	127-130	N-glycanase 1	Homo sapiens	40-46
9184148-0	1997	The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change.	Asparagine	34-37	serpin family C member 1	Homo sapiens	51-63
9184148-0	1997	The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change.	Asparagine	34-37	serpin family C member 1	Homo sapiens	80-92
9184148-1	1997	The beta-form of antithrombin, lacking a carbohydrate side chain on Asn-135, is known to bind heparin more tightly than the fully glycosylated alpha-form.	Asparagine	68-71	serpin family C member 1	Homo sapiens	17-29
9184148-7	1997	The carbohydrate side chain at Asn-135 thus reduces the heparin affinity of alpha-antithrombin primarily by interfering with the heparin-induced conformational change.	Asparagine	31-34	serpin family C member 1	Homo sapiens	82-94
9174192-6	1997	This enzyme differed from TEM-1 (blaT-1B gene) by four amino acid substitutions: Met--&gt;Leu-69, Glu--&gt;Lys-104, Gly--&gt;Ser-238 and Asn--&gt;Asp-276.	Asparagine	137-140	hypothetical protein	Escherichia coli	26-31
9354393-3	1997	The Saccharomyces cerevisiae mutant with a disrupted CCC2 gene (yeast Menkes/Wilson disease gene homologue) was rescued by the cDNA for the C. elegans Cu2+-ATPase but not by the cDNA with an Asp-786 (an invariant phosphorylation site) to Asn mutation, suggesting that the C. elegans Cu2+-ATPase functions as a copper transporter in yeast.	Asparagine	238-241	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	53-57
12223730-9	1997	The inhibition of the induction of NR and NiR activities in the presence of Gln and Asn is a direct effect and is not the result of altered nitrate uptake in the presence of these metabolites.	Asparagine	84-87	nitrate reductase [NADH] 1	Zea mays	35-37
9223879-3	1997	A further investigation by mutagenesis suggests that a direct interaction between subtype specific ligands and specific amino acids such as Phe (412) and Asn (312) in the seventh transmembrane domain of the alpha 2 and beta 2 adrenoceptors respectively.	Asparagine	154-157	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	219-225
12223730-9	1997	The inhibition of the induction of NR and NiR activities in the presence of Gln and Asn is a direct effect and is not the result of altered nitrate uptake in the presence of these metabolites.	Asparagine	84-87	ferredoxin--nitrite reductase, chloroplastic	Zea mays	42-45
12223730-5	1997	The induction of root nitrite reductase (NiR) activity was also reduced in the presence of Asn or Gln and enhanced in the presence of Suc.	Asparagine	91-94	ferredoxin--nitrite reductase, chloroplastic	Zea mays	22-39
9162039-9	1997	The MALDI-TOF mass spectra of COMP from bovine fetal and adult cartilage were compared, indicating a more heterogeneous pattern of substitution at Asn-101 in the fetal form.	Asparagine	147-150	cartilage oligomeric matrix protein	Homo sapiens	30-34
12223730-5	1997	The induction of root nitrite reductase (NiR) activity was also reduced in the presence of Asn or Gln and enhanced in the presence of Suc.	Asparagine	91-94	ferredoxin--nitrite reductase, chloroplastic	Zea mays	41-44
9169007-9	1997	These results demonstrate that heterogeneous glycosylation of Asn 155 of recombinant antithrombin is responsible for generating the low heparin affinity glycoform.	Asparagine	62-65	serpin family C member 1	Homo sapiens	85-97
9144469-10	1997	RNKP-7 is most closely related to granzymes F and G. Modeling of the predicted proteins suggests large/polar P1 (Gln/Asn) specificity for RNKP-4 and large/hydrophobic P1 (e.g., Phe) specificity for RNKP-7.	Asparagine	117-120	granzyme F	Rattus norvegicus	0-6
9144469-10	1997	RNKP-7 is most closely related to granzymes F and G. Modeling of the predicted proteins suggests large/polar P1 (Gln/Asn) specificity for RNKP-4 and large/hydrophobic P1 (e.g., Phe) specificity for RNKP-7.	Asparagine	117-120	granzyme F	Rattus norvegicus	198-204
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Asparagine	270-273	serpin family E member 1	Homo sapiens	0-5
9210490-3	1997	To investigate the role of N-glycosylation in the function of DPPIV, three of its asparagine residues were separately converted to glutamine by site-directed mutagenesis.	Asparagine	82-92	dipeptidylpeptidase 4	Rattus norvegicus	62-67
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Asparagine	270-273	plasminogen activator, tissue type	Homo sapiens	66-70
9139722-10	1997	The active forms of both PAI-1-P10(Ser --&gt; Pro) and PAI-1-P18(Asn --&gt; Pro) are also labile but, in contrast to the active form of wtPAI-1, convert into substrate forms.	Asparagine	65-68	serpin family E member 1	Homo sapiens	25-30
9139722-10	1997	The active forms of both PAI-1-P10(Ser --&gt; Pro) and PAI-1-P18(Asn --&gt; Pro) are also labile but, in contrast to the active form of wtPAI-1, convert into substrate forms.	Asparagine	65-68	serpin family E member 1	Homo sapiens	55-60
9283624-9	1997	Deletion of CT by 84% did not affect CO2 sensitivity, but replacement of 5 arginines (R) with asparagines (N) at the beginning of CT (C1) greatly enhanced the CO2 sensitivity of Cx32.	Asparagine	94-105	gap junction protein beta 1 L homeolog	Xenopus laevis	178-182
9139722-10	1997	The active forms of both PAI-1-P10(Ser --&gt; Pro) and PAI-1-P18(Asn --&gt; Pro) are also labile but, in contrast to the active form of wtPAI-1, convert into substrate forms.	Asparagine	65-68	H3 histone pseudogene 12	Homo sapiens	61-64
9115256-2	1997	A computer-generated model of the thyrotropin-releasing hormone receptor (TRH-R) indicated that conserved Asp-71 (TM-2) could interact with conserved asparagines 316 (TM-7) and 43 (TM-1).	Asparagine	150-161	thyrotropin releasing hormone receptor	Homo sapiens	34-72
9115256-2	1997	A computer-generated model of the thyrotropin-releasing hormone receptor (TRH-R) indicated that conserved Asp-71 (TM-2) could interact with conserved asparagines 316 (TM-7) and 43 (TM-1).	Asparagine	150-161	thyrotropin releasing hormone receptor	Homo sapiens	74-79
9163585-3	1997	We now present investigations from two HbC compound heterozygotes which exhibit opposing effects upon HbC crystallization: HbC/Hb N-Baltimore (beta95 Lys--&gt;Glu) and HbC/Hb Riyadh (beta120 Lys--&gt;Asn).	Asparagine	200-203	keratin 88, pseudogene	Homo sapiens	39-42
9601847-3	1997	The sequential analysis of the beta-globin gene provided evidence that the cause is mutation CAT-AAT in codon 63 which leads to the exchange of distal histidine /E7/ for asparagine.	Asparagine	170-180	serpin family A member 1	Homo sapiens	97-100
9160248-0	1997	Specific proteolytic cleavage of the myristoylated alanine-rich C kinase substrate between Asn 147 and Glu 148 also occurs in brain.	Asparagine	91-94	myristoylated alanine rich protein kinase C substrate	Bos taurus	37-82
9125501-5	1997	An energy decomposition analysis indicates that specific MDH residues (Arg-81, Arg-87, Asn-119, Asp-150, and Arg-153) in the vicinity of the substrate make significant energetic contributions to the stabilization of proton transfer and destabilization of hydride transfer.	Asparagine	87-90	malic enzyme 1	Homo sapiens	57-60
9144530-8	1997	The results showed that Asn-47 and Asp-47 decreased the bioactivity of these mutants by 50- and 700-fold respectively, while the Kd to its high affinity receptors was increased 180- and 90-fold respectively, compared to IL-2.	Asparagine	24-27	interleukin 2	Homo sapiens	220-224
9108480-5	1997	Therefore, RGS4 appears to catalyze rapid hydrolysis of GTP primarily by stabilizing the switch regions of G(i alpha1), although the conserved Asn-128 from RGS4 could also play a catalytic role by interacting with the hydrolytic water molecule or the side chain of Gln-204.	Asparagine	143-146	regulator of G protein signaling 4	Homo sapiens	156-160
9100018-6	1997	In addition, mutation of Glu to Gly or Asn led to increases in their binding to the thyroid hormone response elements (TREs) as homodimers and as heterodimers with the retinoid X receptor.	Asparagine	39-42	retinoid X receptor alpha	Homo sapiens	168-187
9144407-3	1997	The deduced amino-acid sequence contains many structural features, that are highly conserved among all carboxylesterase isoenzymes, like the serine esterase active site, an ER-retention signal and one Asn-Xxx-Thr site for N-linked carbohydrate addition.	Asparagine	201-204	carboxylesterase 2	Homo sapiens	103-119
9135120-8	1997	Electron density for the crystal structure of the proteinase A complex reveals five residues of the oligosaccharide structure attached to Asn67: Man-(1 --&gt; 2)-alpha-Man-(1 --&gt; 3)-beta-Man-(1 --&gt; 4)-beta-GlcNAc-(1 --&gt; 4)-beta-GlcNAc-Asn-67.	Asparagine	138-141	proteinase A	Saccharomyces cerevisiae S288C	50-62
9135120-8	1997	Electron density for the crystal structure of the proteinase A complex reveals five residues of the oligosaccharide structure attached to Asn67: Man-(1 --&gt; 2)-alpha-Man-(1 --&gt; 3)-beta-Man-(1 --&gt; 4)-beta-GlcNAc-(1 --&gt; 4)-beta-GlcNAc-Asn-67.	Asparagine	138-141	LEM domain containing 3	Homo sapiens	145-151
9135120-8	1997	Electron density for the crystal structure of the proteinase A complex reveals five residues of the oligosaccharide structure attached to Asn67: Man-(1 --&gt; 2)-alpha-Man-(1 --&gt; 3)-beta-Man-(1 --&gt; 4)-beta-GlcNAc-(1 --&gt; 4)-beta-GlcNAc-Asn-67.	Asparagine	138-141	LEM domain containing 3	Homo sapiens	168-174
9135120-8	1997	Electron density for the crystal structure of the proteinase A complex reveals five residues of the oligosaccharide structure attached to Asn67: Man-(1 --&gt; 2)-alpha-Man-(1 --&gt; 3)-beta-Man-(1 --&gt; 4)-beta-GlcNAc-(1 --&gt; 4)-beta-GlcNAc-Asn-67.	Asparagine	138-141	LEM domain containing 3	Homo sapiens	168-174
9169089-0	1997	Highly conserved asparagine in the basic domain of Myc is dispensable for DNA binding, transformation, and apoptosis.	Asparagine	17-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	51-54
9083028-7	1997	A CCK-BR mutant was further constructed by replacing five amino acids, Gly-Leu-Ser-Arg-(Arg)-Leu, in the first intracellular loop with the corresponding five CCK-AR specific amino acids, Ile-Arg-Asn-Lys-(Arg)-Met.	Asparagine	195-198	cholecystokinin B receptor	Homo sapiens	2-8
9169089-3	1997	One of the amino acid positions displaying this behavior in MyoD aligns with a highly conserved asparagine in Myc.	Asparagine	96-106	myogenic differentiation 1	Homo sapiens	60-64
9163330-4	1997	Glycosidase digestion showed that both polypeptides are glycosylated; the cleavage site could thus be located between Asn-298 and Asn-328, which have been shown to constitute the only two N-glycosylated residues in NaPi-2.	Asparagine	118-121	solute carrier family 34 member 1	Rattus norvegicus	215-221
9163330-4	1997	Glycosidase digestion showed that both polypeptides are glycosylated; the cleavage site could thus be located between Asn-298 and Asn-328, which have been shown to constitute the only two N-glycosylated residues in NaPi-2.	Asparagine	130-133	solute carrier family 34 member 1	Rattus norvegicus	215-221
9108299-7	1997	In contrast to cathepsins L, S, K, B, H and O, cathepsin W contains a 21-amino acid peptide insertion between the putative active site histidine and asparagine residues and an 8-amino acid C-terminal extension.	Asparagine	149-159	cathepsin W	Homo sapiens	47-58
9169089-3	1997	One of the amino acid positions displaying this behavior in MyoD aligns with a highly conserved asparagine in Myc.	Asparagine	96-106	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	110-113
9169089-5	1997	To test the possibility of whether the basic region of Myc encodes a second biological function, the conserved asparagine in c-Myc (N360) was mutated to alanine and tested for the Myc-dependent functions of cellular transformation and apoptosis.	Asparagine	111-121	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	125-130
9169089-5	1997	To test the possibility of whether the basic region of Myc encodes a second biological function, the conserved asparagine in c-Myc (N360) was mutated to alanine and tested for the Myc-dependent functions of cellular transformation and apoptosis.	Asparagine	111-121	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	127-130
9173867-0	1997	DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics.	Asparagine	71-81	DNA polymerase beta	Rattus norvegicus	0-19
9136948-3	1997	Previously, the rare allele TNFB*1 of the TNF-beta/lymphotoxin (LT)-alpha gene (NcoI, asparagine at amino acid position 26) was found to be associated with a stronger LT-alpha response of PBMC in vitro.	Asparagine	86-96	lymphotoxin alpha	Homo sapiens	28-32
9136948-3	1997	Previously, the rare allele TNFB*1 of the TNF-beta/lymphotoxin (LT)-alpha gene (NcoI, asparagine at amino acid position 26) was found to be associated with a stronger LT-alpha response of PBMC in vitro.	Asparagine	86-96	tumor necrosis factor	Homo sapiens	28-31
9136948-3	1997	Previously, the rare allele TNFB*1 of the TNF-beta/lymphotoxin (LT)-alpha gene (NcoI, asparagine at amino acid position 26) was found to be associated with a stronger LT-alpha response of PBMC in vitro.	Asparagine	86-96	lymphotoxin alpha	Homo sapiens	167-175
9112026-5	1997	We screened 84 white NIDDM patients of Danish ancestry and found four nucleotide substitutions that changed the sequence of HNF-1 alpha, Ile27--&gt;Leu, Ala98--&gt;Val, Ser487--&gt;Asn and Arg583--&gt;Gln, five nucleotide substitutions that were silent and did not change the amino acid, Leu17, Gly288, Leu459 and Thr515, and five substitutions in the intron regions.	Asparagine	181-184	HNF1 homeobox A	Homo sapiens	124-135
9176120-2	1997	We here describe the expression in chinese hamster ovary (CHO) cells of rat CD59 and a modified rat CD59 in which an N-glycosylation site at Asn-16 has been deleted by point mutation.	Asparagine	141-144	CD59 molecule	Rattus norvegicus	100-104
9148753-5	1997	The N-terminal sequence of the two fragments generated by MMP-2 and MMP-3 is Leu211-Lys-Gly-Leu-Asn, but that of the others is Asp1-Glu-Ala-Ser-Gly.	Asparagine	96-99	matrix metallopeptidase 2	Homo sapiens	58-63
9065453-2	1997	To investigate the role in catalysis and/or substrate binding of the Walker motif residues of rat testis fructose 6-phosphate, 2-kinase:fructose-2,6-bisphosphatase (Fru 6-P,2-kinase:Fru-2,6-Pase), we have constructed and characterized mutant enzymes of Asp-128, Thr-52, Asn-73, Thr-130, and Tyr-197.	Asparagine	270-273	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	105-163
9148753-5	1997	The N-terminal sequence of the two fragments generated by MMP-2 and MMP-3 is Leu211-Lys-Gly-Leu-Asn, but that of the others is Asp1-Glu-Ala-Ser-Gly.	Asparagine	96-99	matrix metallopeptidase 3	Homo sapiens	68-73
9119391-10	1997	The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site.	Asparagine	130-140	glutamic--pyruvic transaminase	Homo sapiens	20-23
9062131-7	1997	N-Terminal sequencing of the M(r) 45,000 polypeptide in the purified preparation of aminopeptidase A revealed that it resulted from cleavage at the Asn-602-Gly-603 bond by an endogenous protease.	Asparagine	148-151	glutamyl aminopeptidase	Homo sapiens	84-100
9119391-10	1997	The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site.	Asparagine	130-140	glutamic--pyruvic transaminase 2	Homo sapiens	144-149
9132061-13	1997	However, they do show two differences of importance to peroxidase catalysis: (1) the asparagine residue linked with the active site distal histidine via hydrogen bonding is absent; (2) an N-glycosylation site is located right at the entrance to the heme channel.	Asparagine	85-95	peroxidase	Arabidopsis thaliana	55-65
9099948-8	1997	M(r) approximately 94,000) M(r) fractions of mZP3 were purified and shown to vary in extent of asparagine-linked (N-linked) glycosylation.	Asparagine	95-105	zona pellucida glycoprotein 3	Mus musculus	45-49
9065690-3	1997	We show that Gln3p activates CAR1 expression through the GATAA sequences in the absence of an optimal nitrogen source, such as ammonia, glutamine or asparagine.	Asparagine	149-159	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	13-18
9041517-3	1997	The overall structure of TRAP is conserved in all species; specifically, an amino-terminal A-domain similar to magnesium-binding domains of mammalian integrins; a thrombospondin-like sulfatide-binding domain similar to region II in Plasmodium circumsporozoite protein; an acidic asparagine/proline-rich repeat region; a trans-membrane domain and a short acidic cytoplasmic region with a highly conserved carboxy terminus.	Asparagine	279-289	TRAP	Homo sapiens	25-29
9013598-6	1997	Sequence analysis of tryptic peptides obtained from somatic ACE (human kidney) identified six glycosylated and one unglycosylated Asn.	Asparagine	130-133	angiotensin I converting enzyme	Homo sapiens	60-63
9000456-6	1997	A missense mutation (AAT to AGT) was identified in the codon corresponding to codon 361 of the deduced human TrkC sequence, converting an encoded Asn to Ser.	Asparagine	146-149	serpin family A member 1	Homo sapiens	21-24
9000456-6	1997	A missense mutation (AAT to AGT) was identified in the codon corresponding to codon 361 of the deduced human TrkC sequence, converting an encoded Asn to Ser.	Asparagine	146-149	angiotensinogen	Homo sapiens	28-31
9000456-6	1997	A missense mutation (AAT to AGT) was identified in the codon corresponding to codon 361 of the deduced human TrkC sequence, converting an encoded Asn to Ser.	Asparagine	146-149	neurotrophic receptor tyrosine kinase 3	Homo sapiens	109-113
8994189-3	1997	We generated a recombinant adenovirus encoding dominant negative ras by cloning the human H-ras cDNA with a ser to asn substitution at amino acid 17 (ras(asn17)) into the pACCMVpLpA vector and cotransfecting 293 cells with the pJM17 plasmid containing the adenoviral genome.	Asparagine	115-118	HRas proto-oncogene, GTPase	Homo sapiens	90-95
9173240-0	1997	[Theoretical study of the spatial structure of the Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr segment of the HIV gp120 protein, responsible for binding of the virus with the T-cell T4 receptor].	Asparagine	71-74	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	102-107
9078248-3	1997	Labelling of both subunits was blocked competitively by the acceptor peptide N-benzoyl-Asu-Gly-Thr-NHCH3 and by the OST inhibitor N-benzoyl-alpha,gamma-diaminobutyric acid-Gly-Thr-NHCH3, but not by an analogue derived from the epoxy-inhibitor by replacing asparagine with glutamine.	Asparagine	256-266	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	116-119
8943297-9	1996	We propose that: (i) alpha-D258 is a Mor "contact site"; and (ii) residues Leu-262, Arg-265, and Asn-268 indirectly affect Mor-polymerase interaction by stabilizing the ternary complex via alpha-DNA contact.	Asparagine	97-100	Mor	Escherichia phage Mu	37-40
8943297-9	1996	We propose that: (i) alpha-D258 is a Mor "contact site"; and (ii) residues Leu-262, Arg-265, and Asn-268 indirectly affect Mor-polymerase interaction by stabilizing the ternary complex via alpha-DNA contact.	Asparagine	97-100	Mor	Escherichia phage Mu	123-126
9023547-3	1996	As a precisely defined ligand, we have employed bovine asialofetuin (ASF), a glycoprotein that possesses three asparagine-linked triantennary complex carbohydrate chains with terminal LacNAc residues.	Asparagine	111-121	alpha 2-HS glycoprotein	Bos taurus	55-67
8961926-0	1996	Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor.	Asparagine	0-10	fibroblast growth factor receptor 2	Homo sapiens	54-89
8961926-8	1996	Asparagine-344 is, therefore, essential for ligand binding by KGFR.	Asparagine	0-10	fibroblast growth factor receptor 2	Homo sapiens	62-66
8997180-8	1996	Site-directed mutagenesis of the two consensus sequences for N-glycosylation in the NaDC-1 cDNA showed that Asn-576, located near the COOH-terminal, is glycosylated.	Asparagine	108-111	solute carrier family 13 member 2	Oryctolagus cuniculus	84-90
8982067-3	1996	The Hor v 9 cDNA clone (hvp9742) contained an open reading frame encoding 313 amino acids which included a putative 27-residue signal peptide and one asparagine sequon for glycosylation.	Asparagine	150-160	HORV9	Hordeum vulgare	4-11
8997197-7	1996	When the neutral asparagine residue within the second putative membrane-spanning domain of the ROMK channel was substituted with aspartic acid, the corresponding amino acid in IRK1, the degree of inward rectification was enhanced but Ba2+ block and single-channel inward conductance were unaffected.	Asparagine	17-27	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	95-99
8997197-7	1996	When the neutral asparagine residue within the second putative membrane-spanning domain of the ROMK channel was substituted with aspartic acid, the corresponding amino acid in IRK1, the degree of inward rectification was enhanced but Ba2+ block and single-channel inward conductance were unaffected.	Asparagine	17-27	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	176-180
9023547-3	1996	As a precisely defined ligand, we have employed bovine asialofetuin (ASF), a glycoprotein that possesses three asparagine-linked triantennary complex carbohydrate chains with terminal LacNAc residues.	Asparagine	111-121	alpha 2-HS glycoprotein	Bos taurus	69-72
8942999-5	1996	The mutation in the 25-RA cells resulted from a G-to-A transition in codon 443 of the SCAP gene, changing aspartic acid to asparagine.	Asparagine	123-133	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	86-90
9010776-7	1996	We isolated a candidate cDNA for ABP-2, and the protein it encoded contained nine Zn fingers and regions rich in alanine, glutamine, serine/threonine, glycine, histidine, and asparagine.	Asparagine	175-185	lava lamp	Drosophila melanogaster	33-38
8939904-1	1996	A previous study using random mutagenesis identified an activating mutation in the common beta subunit (hbetac) of the human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5 receptors in which an isoleucine residue (Ile374) in the extracellular region of hbetac is replaced by asparagine (Jenkins, B. J., D"Andrea, R., and Gonda, T. J.	Asparagine	311-321	interleukin 3	Homo sapiens	90-188
8939904-1	1996	A previous study using random mutagenesis identified an activating mutation in the common beta subunit (hbetac) of the human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5 receptors in which an isoleucine residue (Ile374) in the extracellular region of hbetac is replaced by asparagine (Jenkins, B. J., D"Andrea, R., and Gonda, T. J.	Asparagine	311-321	interleukin 5	Homo sapiens	194-207
8910546-2	1996	We report here that mutation of two tryptic cleavage sites (Lys164 and Lys582 --&gt; Asn; 2N) in the insulin receptor alpha-subunit results in a cell-line (CHO.2N-10) with altered morphology associated with an increase in cell size, a decrease in cell adhesiveness, and a decrease in pp125(FAK) tyrosine phosphorylation in the absence of insulin (45.2 +/- 9.7% compared to nontransfected Chinese hamster ovary (CHO) cells).	Asparagine	85-88	insulin receptor	Cricetulus griseus	101-117
8910570-16	1996	mRNA for apoB100 increased with asparagine, decreased moderately with branched chain amino acids, and decreased further with glutamine, as shown by dot blot and Northern blotting.	Asparagine	32-42	apolipoprotein B	Homo sapiens	9-16
8910481-0	1996	A mouse amidase specific for N-terminal asparagine.	Asparagine	40-50	amidase	Saccharomyces cerevisiae S288C	8-15
8910481-4	1996	We report the isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-terminal asparagine.	Asparagine	181-191	N-terminal Asn amidase	Mus musculus	88-93
8910481-4	1996	We report the isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-terminal asparagine.	Asparagine	181-191	neurturin	Mus musculus	144-147
8910481-4	1996	We report the isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-terminal asparagine.	Asparagine	181-191	amidase	Saccharomyces cerevisiae S288C	148-155
8910481-8	1996	The deduced amino acid sequence of mouse NtN-amidase is 88% identical to the sequence of its porcine counterpart, but bears no significant similarity to the sequence of the NTA1-encoded N-terminal amidohydrolase of the yeast Saccharomyces cerevisiae, which can deamidate either N-terminal asparagine or glutamine.	Asparagine	289-299	neurturin	Mus musculus	41-44
8910481-8	1996	The deduced amino acid sequence of mouse NtN-amidase is 88% identical to the sequence of its porcine counterpart, but bears no significant similarity to the sequence of the NTA1-encoded N-terminal amidohydrolase of the yeast Saccharomyces cerevisiae, which can deamidate either N-terminal asparagine or glutamine.	Asparagine	289-299	amidase	Saccharomyces cerevisiae S288C	45-52
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	111-121	neurturin	Mus musculus	24-27
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	111-121	amidase	Saccharomyces cerevisiae S288C	28-35
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	111-121	neurturin	Mus musculus	87-90
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	111-121	amidase	Saccharomyces cerevisiae S288C	91-98
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	164-174	neurturin	Mus musculus	24-27
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	164-174	amidase	Saccharomyces cerevisiae S288C	28-35
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	164-174	neurturin	Mus musculus	87-90
8910481-9	1996	The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule.	Asparagine	164-174	amidase	Saccharomyces cerevisiae S288C	91-98
8917642-5	1996	From the modeling analysis, we found that the carbonyl oxygen of the N-acetyl group of GlcNAc in 3 formed a hydrogen bond with the amide group of Asn 82 in P-selectin.	Asparagine	146-149	selectin P	Homo sapiens	156-166
8898195-3	1996	Sterol resistance was traced to a G--&gt;A transition at codon 443 of SCAP, changing aspartic acid to asparagine.	Asparagine	102-112	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	70-74
8895751-1	1996	This study reports a C--&gt;A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1), resulting in a threonine-asparagine exchange in codon 461.	Asparagine	127-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-91
8951815-1	1996	Two new yeast genes, named ASN1 and ASN2, were isolated by complementation of the growth defect of an asparagine auxotrophic mutant.	Asparagine	102-112	asparagine synthase (glutamine-hydrolyzing) 1	Saccharomyces cerevisiae S288C	27-31
8895751-1	1996	This study reports a C--&gt;A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1), resulting in a threonine-asparagine exchange in codon 461.	Asparagine	127-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
8892902-11	1996	In addition, high-level production of tumor necrosis factor alpha by infected BALB/c monocytes is associated with asparagine at amino acid 165 of VP2 as has been previously demonstrated for the H3 virus.	Asparagine	114-124	tumor necrosis factor	Mus musculus	38-65
9007588-5	1996	All of the six patients developed one or more of the HIV-1 pol mutations known to confer resistance to ZDV in vitro (Met41--&gt;Leu, Asp67--&gt;Asn, Lys70--&gt;Arg, Thr215--&gt;Phe/Tyr, Lys219--&gt;Gln/Glu).	Asparagine	144-147	endogenous retrovirus group W member 4	Homo sapiens	59-62
8930157-6	1996	A single acidic residue (Asp98) present in the rat secretin receptor appears to be critical, because a site-mutant changing this to the polar, but uncharged residue present in that position in the human receptor (Asn) eliminates the high affinity binding of VIP.	Asparagine	213-216	secretin receptor	Rattus norvegicus	51-68
8930157-6	1996	A single acidic residue (Asp98) present in the rat secretin receptor appears to be critical, because a site-mutant changing this to the polar, but uncharged residue present in that position in the human receptor (Asn) eliminates the high affinity binding of VIP.	Asparagine	213-216	vasoactive intestinal peptide	Homo sapiens	258-261
8951815-1	1996	Two new yeast genes, named ASN1 and ASN2, were isolated by complementation of the growth defect of an asparagine auxotrophic mutant.	Asparagine	102-112	asparagine synthase (glutamine-hydrolyzing) 2	Saccharomyces cerevisiae S288C	36-40
8873604-7	1996	When the interaction of Na+ with the B2 receptor was prevented by exchanging a conserved aspartate in transmembrane domain II for asparagine the B2 receptor was also constitutively-activated in the absence of agonist.	Asparagine	130-140	bradykinin receptor B2	Homo sapiens	37-48
8932375-0	1996	Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.	Asparagine	0-10	huntingtin associated protein 1	Homo sapiens	93-97
8932375-8	1996	This study indicates that chelation of the active site metal ion in HAP1 stabilizes the complex of the protein with AP sites and identifies an active site asparagine residue as an important component of AP site recognition by the HAP1 protein.	Asparagine	155-165	huntingtin associated protein 1	Homo sapiens	68-72
8932375-8	1996	This study indicates that chelation of the active site metal ion in HAP1 stabilizes the complex of the protein with AP sites and identifies an active site asparagine residue as an important component of AP site recognition by the HAP1 protein.	Asparagine	155-165	huntingtin associated protein 1	Homo sapiens	230-234
8973094-0	1996	Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250--&gt;Asn; Ser251--&gt;Cys) resulting in lipoprotein lipase (LPL) deficiency.	Asparagine	99-102	lipoprotein lipase	Homo sapiens	62-80
8973094-0	1996	Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250--&gt;Asn; Ser251--&gt;Cys) resulting in lipoprotein lipase (LPL) deficiency.	Asparagine	99-102	lipoprotein lipase	Homo sapiens	134-152
8873604-7	1996	When the interaction of Na+ with the B2 receptor was prevented by exchanging a conserved aspartate in transmembrane domain II for asparagine the B2 receptor was also constitutively-activated in the absence of agonist.	Asparagine	130-140	bradykinin receptor B2	Homo sapiens	145-156
8790154-0	1996	Fibrinogen Matsumoto II: gamma 308 Asn--&gt;Lys (AAT--&gt;AAG) mutation associated with bleeding tendency.	Asparagine	35-38	serpin family A member 1	Homo sapiens	49-52
8814222-7	1996	Furthermore, selective decrease in CS-ST activity was also observed in the alanine mutant at lysine 254 or at asparagine 255 of the ST-40 enzyme.	Asparagine	110-120	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6	Rattus norvegicus	132-137
8814222-8	1996	Kinetic analysis on the ST-40 and its mutant at asparagine 255 indicated that the Km value for CS was significantly increased in the mutant without any change in the Km values for 3"-phosphoadenosine 5"-phosphosulfate and DHEA.	Asparagine	48-58	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6	Rattus norvegicus	24-29
8837740-6	1996	A human PGHS-2 (hPGHS-2) mutant in which the C-terminal leucine residue was replaced with an asparagine (hPGHS-2 L604N) was also found to localize to the Golgi apparatus following 18 h expression in transfected cos-1 cells.	Asparagine	93-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	8-14
8837740-6	1996	A human PGHS-2 (hPGHS-2) mutant in which the C-terminal leucine residue was replaced with an asparagine (hPGHS-2 L604N) was also found to localize to the Golgi apparatus following 18 h expression in transfected cos-1 cells.	Asparagine	93-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-23
8837740-6	1996	A human PGHS-2 (hPGHS-2) mutant in which the C-terminal leucine residue was replaced with an asparagine (hPGHS-2 L604N) was also found to localize to the Golgi apparatus following 18 h expression in transfected cos-1 cells.	Asparagine	93-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-112
8879197-6	1996	Such a ranking reveals that the ability of the 3.L2 T cell to respond to these peptides depends on how well the structure of the side chain at the primary TCR contact site mimics that of the Asn residue present in the antigenic ligand.	Asparagine	191-194	T cell receptor alpha variable 6-3	Mus musculus	155-158
8798614-2	1996	Approximately 50% of the total apparent mass of CD59 is attributable to glycosylation of a single Asn (Asn18).	Asparagine	98-101	CD59 molecule (CD59 blood group)	Homo sapiens	48-52
8798464-4	1996	Primary structure analysis of UGT2B17 based on the nucleotide sequence revealed a putative amino-terminal membrane insertion signal peptide, a carboxyl-terminal membrane-spanning region, and three potential asparagine-linked glycosylation sites.	Asparagine	207-217	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	30-37
8905031-1	1996	BACKGROUND: Monitoring L-asparagine (L-ASN) plasma levels could provide information useful for determining whether the dosage or schedule of L-asparaginase (L-ASE) administration is adequate.	Asparagine	23-35	asparaginase and isoaspartyl peptidase 1	Homo sapiens	141-155
8905031-1	1996	BACKGROUND: Monitoring L-asparagine (L-ASN) plasma levels could provide information useful for determining whether the dosage or schedule of L-asparaginase (L-ASE) administration is adequate.	Asparagine	23-35	asparaginase and isoaspartyl peptidase 1	Homo sapiens	157-162
8905031-1	1996	BACKGROUND: Monitoring L-asparagine (L-ASN) plasma levels could provide information useful for determining whether the dosage or schedule of L-asparaginase (L-ASE) administration is adequate.	Asparagine	37-42	asparaginase and isoaspartyl peptidase 1	Homo sapiens	141-155
8905031-1	1996	BACKGROUND: Monitoring L-asparagine (L-ASN) plasma levels could provide information useful for determining whether the dosage or schedule of L-asparaginase (L-ASE) administration is adequate.	Asparagine	37-42	asparaginase and isoaspartyl peptidase 1	Homo sapiens	157-162
8905031-11	1996	RESULTS: L-ASN plasma depletion was observed in 80% of the cases during the first exposure to conventional doses of L-ASE and only in 25% of the cases during the second or third exposures to either conventional or high doses of L-ASE.	Asparagine	9-14	asparaginase and isoaspartyl peptidase 1	Homo sapiens	116-121
8905031-11	1996	RESULTS: L-ASN plasma depletion was observed in 80% of the cases during the first exposure to conventional doses of L-ASE and only in 25% of the cases during the second or third exposures to either conventional or high doses of L-ASE.	Asparagine	9-14	asparaginase and isoaspartyl peptidase 1	Homo sapiens	228-233
8905031-14	1996	CONCLUSIONS: L-ASN plasma depletion is regularly obtained in the majority of patients during the first exposure to conventional doses of E. chrysanthemi L-ASE.	Asparagine	13-18	asparaginase and isoaspartyl peptidase 1	Homo sapiens	153-158
8905031-16	1996	Studies should be performed to evaluate whether L-ASE derived from different species or conjugated with polyethylene-glycole are effective in obtaining L-ASN plasma depletion in patients previously treated with Erwinia C. L-ASE.	Asparagine	152-157	asparaginase and isoaspartyl peptidase 1	Homo sapiens	48-53
8905031-16	1996	Studies should be performed to evaluate whether L-ASE derived from different species or conjugated with polyethylene-glycole are effective in obtaining L-ASN plasma depletion in patients previously treated with Erwinia C. L-ASE.	Asparagine	152-157	asparaginase and isoaspartyl peptidase 1	Homo sapiens	222-227
8790154-0	1996	Fibrinogen Matsumoto II: gamma 308 Asn--&gt;Lys (AAT--&gt;AAG) mutation associated with bleeding tendency.	Asparagine	35-38	N-methylpurine DNA glycosylase	Homo sapiens	58-61
8790154-4	1996	Fibrinogen gamma-chain gene of the propositus was heterozygous for a missense mutation that resulted in Asn--&gt;Lys substitution at codon 308.	Asparagine	104-107	fibrinogen gamma chain	Homo sapiens	0-22
9183647-13	1996	The biological function of the central cell adhesive region requires two critical amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence, which function in synergy--for optimal binding to the alpha 5 beta 1 integrin.	Asparagine	156-159	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	240-246
8855358-2	1996	An aspartate- and glutamate-rich portion of hirudin plays an important part in its tight binding to thrombin through a ladder of salt bridges, and these residues have previously been mutated to asparagine or glutamine.	Asparagine	194-204	coagulation factor II, thrombin	Homo sapiens	100-108
8808922-5	1996	In addition, Hyr1p contained a second domain rich in glycine, serine, and asparagine (79% of 239 residues).	Asparagine	74-84	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	13-18
8883274-8	1996	In the variant gamma 337 Asn--&gt;Lys, the thrombin time was abnormally prolonged at 0.01 mM Ca2+, but it was normalized at 1 mM calcium.	Asparagine	25-28	coagulation factor II, thrombin	Homo sapiens	43-51
8761494-7	1996	Two potential Asn-glycosylation sites are also conserved, both of which appear to be glycosylated in sheep and bovine CA VI.	Asparagine	14-17	carbonic anhydrase 6	Bos taurus	118-123
8757293-8	1996	The PR3 structure includes a disaccharide unit (N-linked 2-acetamido-2-deoxy-beta-D-glucopyranose and 1,6-linked alpha-L-fucopyranose) covalently attached to Asn 159.	Asparagine	158-161	proteinase 3	Homo sapiens	4-7
8701949-3	1996	DNA sequence analysis showed GTG at codon 6 in exon 1, corresponding to Hb S and AAT at codon 145 in exon 3, indicating a substitution of Asn for Tyr.	Asparagine	138-141	serpin family A member 1	Homo sapiens	81-84
8769411-4	1996	First, the presence of the uncharged amino acid, asparagine, at the penultimate residue of the human catalase PTS is highly unusual, in that a basic residue at this position has been previously found to be a common and critical feature of PTS1 signals.	Asparagine	49-59	catalase	Homo sapiens	101-109
8780462-5	1996	All resistant isolates possessed mutations in the DHFR gene at codon 108, the majority changing from Ser to Asn, but one isolate from Ser to Thr, a change not previously reported in field isolates.	Asparagine	108-111	dihydrofolate reductase	Homo sapiens	50-54
8871046-12	1996	In the latter region, Asn 370 and 295 are critical in the interaction with the lectin CD23.	Asparagine	22-25	Fc epsilon receptor II	Homo sapiens	86-90
8769411-5	1996	Nonetheless, this asparagine residue appears to constitute an important component of the catalase PTS, in that replacement with aspartate abolished peroxisomal targeting (as did deletion of the COOH-terminal four residues).	Asparagine	18-28	catalase	Homo sapiens	89-97
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Asparagine	291-301	Pex5p	Saccharomyces cerevisiae S288C	89-94
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Asparagine	291-301	peroxisomal biogenesis factor 5	Homo sapiens	131-144
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Asparagine	291-301	catalase	Homo sapiens	197-205
8752926-2	1996	Here we demonstrate that the I-Ak molecule preferentially binds peptides that contain negatively charged amino acids at the primary anchor position (Asp or Glu at P1), and that I-Ak can also bind peptides with polar residues at P1 (Cys, Ser, Asn, Gin, or Thr), although with lower affinity.	Asparagine	242-245	aurora kinase A	Mus musculus	29-33
8780657-4	1996	An apparent asymmetric positioning of the NR1- and NR2-subunit N-site asparagines may account for their unequal role in Ca2+ permeability and Mg2+ block.	Asparagine	70-81	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	42-45
8752926-2	1996	Here we demonstrate that the I-Ak molecule preferentially binds peptides that contain negatively charged amino acids at the primary anchor position (Asp or Glu at P1), and that I-Ak can also bind peptides with polar residues at P1 (Cys, Ser, Asn, Gin, or Thr), although with lower affinity.	Asparagine	242-245	aurora kinase A	Mus musculus	177-181
8660692-0	1996	Active-site topologies of human CYP2D6 and its aspartate-301 --&gt; glutamate, asparagine, and glycine mutants.	Asparagine	79-89	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38
8688417-2	1996	The glycan important for full biological activity of hCG, namely, that at Asn 52, appears to extend into solution both in the isolated alpha subunit and in complex with the beta subunit.	Asparagine	74-77	chorionic gonadotropin subunit beta 5	Homo sapiens	53-56
8688424-0	1996	Antithrombin-heparin affinity reduced by fucosylation of carbohydrate at asparagine 155.	Asparagine	73-83	serpin family C member 1	Homo sapiens	0-12
8688424-1	1996	The two human plasma antithrombin isoforms, alpha and beta, differ in glycosylation at asparagine 135.	Asparagine	87-97	serpin family C member 1	Homo sapiens	21-33
8663233-11	1996	A peptide corresponding to the carboxyl-terminal 20 amino acids of Ret dissociated Enigma and Ret complexes, while a mutant that changed Asn-Lys-Leu-Tyr in the peptide to Ala-Lys-Leu-Ala or a peptide corresponding to exon16 of InsR failed to disrupt the complexes, indicating the Asn-Lys-Leu-Tyr sequence of Ret is essential to the recognition motif for LIM2 of Enigma.	Asparagine	137-140	ret proto-oncogene	Homo sapiens	67-70
8663233-11	1996	A peptide corresponding to the carboxyl-terminal 20 amino acids of Ret dissociated Enigma and Ret complexes, while a mutant that changed Asn-Lys-Leu-Tyr in the peptide to Ala-Lys-Leu-Ala or a peptide corresponding to exon16 of InsR failed to disrupt the complexes, indicating the Asn-Lys-Leu-Tyr sequence of Ret is essential to the recognition motif for LIM2 of Enigma.	Asparagine	280-283	ret proto-oncogene	Homo sapiens	67-70
8760120-0	1996	Expression of the ornithine decarboxylase gene in response to asparagine in intestinal epithelial cells.	Asparagine	62-72	ornithine decarboxylase 1	Rattus norvegicus	18-41
8760120-2	1996	Of normal dietary constituents, the amino acid asparagine markedly increases ODC activity and mucosal growth when administered intragastrically.	Asparagine	47-57	ornithine decarboxylase 1	Rattus norvegicus	77-80
8760120-3	1996	The current study examined the expression of the ODC gene in IEC-6 cells (a line of normal rat small intestinal crypt cells) after exposure to asparagine.	Asparagine	143-153	ornithine decarboxylase 1	Rattus norvegicus	49-52
8760120-6	1996	Exposure to asparagine at the dose of 10 mM resulted in the rapid increase in ODC mRNA levels.	Asparagine	12-22	ornithine decarboxylase 1	Rattus norvegicus	78-81
8760120-7	1996	The increased expression of the ODC gene began 1 h after and peaked between 3 and 5 h after treatment with asparagine.	Asparagine	107-117	ornithine decarboxylase 1	Rattus norvegicus	32-35
8760120-9	1996	Increased levels of ODC mRNA in cells exposed to asparagine were paralleled by increases in ODC protein and enzyme activity and cellular polyamine levels.	Asparagine	49-59	ornithine decarboxylase 1	Rattus norvegicus	20-23
8760120-9	1996	Increased levels of ODC mRNA in cells exposed to asparagine were paralleled by increases in ODC protein and enzyme activity and cellular polyamine levels.	Asparagine	49-59	ornithine decarboxylase 1	Rattus norvegicus	92-95
8760120-10	1996	The half-life of mRNA for ODC in unstimulated IEC-6 cells was approximately 30 min and increased to &gt; 2 h in cells exposed to 10 mM asparagine.	Asparagine	135-145	ornithine decarboxylase 1	Rattus norvegicus	26-29
8760120-11	1996	The half-life of ODC activity also was increased in asparagine-treated cells.	Asparagine	52-62	ornithine decarboxylase 1	Rattus norvegicus	17-20
8760120-12	1996	When cellular protein synthesis was inhibited by cycloheximide, asparagine superinduced ODC mRNA levels.	Asparagine	64-74	ornithine decarboxylase 1	Rattus norvegicus	88-91
8760120-14	1996	These results indicate that 1) asparagine stimulates ODC in IEC-6 cells through multiple pathways and 2) increased ODC mRNA levels result partly from a delay in the rate of degradation.	Asparagine	31-41	ornithine decarboxylase 1	Rattus norvegicus	53-56
8877373-8	1996	The K(m) of glycosylasparaginase for its normal substrate GlcNAc-Asn was 0.88 mM.	Asparagine	65-68	aspartylglucosaminidase	Homo sapiens	12-32
8670796-1	1996	Aspartylglucosaminidase (AGA) is a lysosomal asparaginase that participates in the breakdown of glycoproteins by cleaving the amide bond between the asparagine and the oligosaccharide chain.	Asparagine	149-159	aspartylglucosaminidase	Homo sapiens	0-23
8700125-2	1996	Mutation of a membrane-embedded aspartate residue, highly conserved among G protein-coupled receptors, in the alpha 2AAR to asparagine (D79N alpha 2AAR) results in selective uncoupling of the receptor to K+ currents but retention of inhibition of cAMP production and of voltage-sensitive Ca2+ currents when expressed in AtT20 anterior pituitary cells in culture.	Asparagine	124-134	adrenergic receptor, alpha 2a	Mus musculus	110-120
8700125-2	1996	Mutation of a membrane-embedded aspartate residue, highly conserved among G protein-coupled receptors, in the alpha 2AAR to asparagine (D79N alpha 2AAR) results in selective uncoupling of the receptor to K+ currents but retention of inhibition of cAMP production and of voltage-sensitive Ca2+ currents when expressed in AtT20 anterior pituitary cells in culture.	Asparagine	124-134	adrenergic receptor, alpha 2a	Mus musculus	141-151
8670172-4	1996	CD59u exhibited an average M(r) of 12444 in MALDI-MS. Mass analysis of the isolated C-terminal peptide (T9) indicated that a GPI-anchor (at Asn-77) without an inositol-associated phospholipid was present in soluble CD59u.	Asparagine	140-143	CD59 molecule (CD59 blood group)	Homo sapiens	0-4
8670172-4	1996	CD59u exhibited an average M(r) of 12444 in MALDI-MS. Mass analysis of the isolated C-terminal peptide (T9) indicated that a GPI-anchor (at Asn-77) without an inositol-associated phospholipid was present in soluble CD59u.	Asparagine	140-143	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
8670172-8	1996	The N-linked carbohydrate side chain of CD59u (at Asn-18) also displayed considerable heterogeneity.	Asparagine	50-53	CD59 molecule (CD59 blood group)	Homo sapiens	40-44
8670796-1	1996	Aspartylglucosaminidase (AGA) is a lysosomal asparaginase that participates in the breakdown of glycoproteins by cleaving the amide bond between the asparagine and the oligosaccharide chain.	Asparagine	149-159	aspartylglucosaminidase	Homo sapiens	25-28
8650234-7	1996	The presence of the unusual conserved Cys-Secys-Gly sequence at the C terminus of TR in addition to the redox active cysteines of the Cys-Val-Asn-Val-Gly-Cys motif in the FAD-binding region may account for the peroxidase activity and the relatively low substrate specificity of mammalian TRs.	Asparagine	142-145	peroxiredoxin 5	Homo sapiens	82-84
8691600-3	1996	AFP is a glycoprotein composed of 590 amino acid residues and has one asparagine-linked sugar chain at the 232nd position from N-terminal of the AFP molecule.	Asparagine	70-80	alpha fetoprotein	Homo sapiens	0-3
8648710-6	1996	The amino acid sequence and hydrophilicity plot predicted that the A33R gene product is a type II membrane protein with two asparagine-linked glycosylation sites.	Asparagine	124-134	EEV membrane phosphoglycoprotein	Vaccinia virus	67-71
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Asparagine	34-37	neurotensin	Homo sapiens	0-11
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Asparagine	34-37	neurotensin	Homo sapiens	13-15
8666161-2	1996	The initial stage in the biosynthesis of N-linked glycoproteins, catalyzed by the enzyme oligosaccharyltransferase (OST), involves the transfer of a preassembled high-mannose oligosaccharide from a dolichol-linked oligosaccharide donor onto asparagine acceptor sites in nascent proteins in the lumen of the rough endoplasmic reticulum.	Asparagine	241-251	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	89-114
8666161-2	1996	The initial stage in the biosynthesis of N-linked glycoproteins, catalyzed by the enzyme oligosaccharyltransferase (OST), involves the transfer of a preassembled high-mannose oligosaccharide from a dolichol-linked oligosaccharide donor onto asparagine acceptor sites in nascent proteins in the lumen of the rough endoplasmic reticulum.	Asparagine	241-251	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	116-119
8691600-3	1996	AFP is a glycoprotein composed of 590 amino acid residues and has one asparagine-linked sugar chain at the 232nd position from N-terminal of the AFP molecule.	Asparagine	70-80	alpha fetoprotein	Homo sapiens	145-148
8639621-3	1996	The protein shares 40% identity with yeast bleomycin hydrolase and contains the conserved active site residues (Cys, His, Asn) characteristic for cysteine proteases of the papain superfamily.	Asparagine	122-125	bleomycin hydrolase	Saccharomyces cerevisiae S288C	43-62
8665951-8	1996	The occurrence of a second, larger form of semenogelin II was due to asparagine-linked glycosylation.	Asparagine	69-79	semenogelin 2	Homo sapiens	43-57
8647812-2	1996	To determine how this localization might be regulated a range of CD44 cytoplasmic domain mutations were generated and a minimal 5 amino acid sequence, His330-Leu-Val-Asn-Lys334, was identified which when deleted results in expression of CD44 on the apical microvillal membrane.	Asparagine	166-169	CD44 molecule	Canis lupus familiaris	65-69
8647812-2	1996	To determine how this localization might be regulated a range of CD44 cytoplasmic domain mutations were generated and a minimal 5 amino acid sequence, His330-Leu-Val-Asn-Lys334, was identified which when deleted results in expression of CD44 on the apical microvillal membrane.	Asparagine	166-169	CD44 molecule	Canis lupus familiaris	237-241
8662771-5	1996	Thus, in addition to 8 tandemly arranged ligand binding repeats, the five-domain receptor contains an O-linked sugar region and the internalization signal, Phe-Asp-Asn-Pro-Val-Tyr, typical for all LDLR gene family members.	Asparagine	164-167	low density lipoprotein receptor	Gallus gallus	197-201
8662772-5	1996	Using a degenerate phosphopeptide library screen, we show that the PTB domain of ShcC preferentially binds the sequence His-hydrophobic-Asn/hydrophobic-Asn-Pro-Ser/Thr-Tyr(P).	Asparagine	136-139	SHC adaptor protein 3	Homo sapiens	81-85
8662772-5	1996	Using a degenerate phosphopeptide library screen, we show that the PTB domain of ShcC preferentially binds the sequence His-hydrophobic-Asn/hydrophobic-Asn-Pro-Ser/Thr-Tyr(P).	Asparagine	152-155	SHC adaptor protein 3	Homo sapiens	81-85
8611496-0	1996	Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.	Asparagine	112-122	thymidylate synthetase	Homo sapiens	130-150
8645182-7	1996	However, PACE-4, a furin-like convertase, is much more efficient on the mouse enzyme, suggesting that ST3 protein determinants other than the conserved Ala-Arg-Asn-Arg-Gln-Lys-Arg sequence preceding the furin cleavage site are implicated in PACE-4 action.	Asparagine	160-163	proprotein convertase subtilisin/kexin type 6	Mus musculus	9-15
11725090-5	1996	The antagonist-binding pocket of the human 5-HT(1A)R is inferred from the interaction sites of pindolol with the receptor model: (1) the ionic interaction between the protonated amine of the ligand and the side chain of the conserved Asp-116, located in TMH 3; and (2) the hydrogen bonds between the ether oxygen and the hydroxyl group of the ligand and Asn-385, located in TMH 7.	Asparagine	354-357	5-hydroxytryptamine receptor 1A	Homo sapiens	43-50
8621648-12	1996	Lumenal localization of the short peptide predicted to lie within the endoplasmic reticulum was further confirmed by in vitro glycosylation of an asparagine-linked glycosylation site present in HMG2.	Asparagine	146-156	3-hydroxy-3-methylglutaryl-coenzyme A reductase 2	Solanum lycopersicum	194-198
8672425-0	1996	Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2"-deoxyuridine 5"-monophosphate.	Asparagine	0-10	thymidylate synthetase	Homo sapiens	26-46
8672425-1	1996	The conserved Asn 229 of thymidylate synthase (TS) forms a cyclic hydrogen bond network with the 3-NH and 4-O of the nucleotide substrate 2"-deoxyuridine 5"-monophosphate (dUMP).	Asparagine	14-17	thymidylate synthetase	Homo sapiens	25-45
9132151-0	1996	Characterization of Ca(2+) flows essential in ornithine decarboxylase induction by L-asparagine in rat hepatoma cells using Ca(2+) flow inhibitors.	Asparagine	83-95	ornithine decarboxylase 1	Rattus norvegicus	46-69
9132151-1	1996	L-Asparagine stimulates bi-directional Ca(2+) flows and induces ornithine decarboxylase in Reuber H-35 hepatoma cells.	Asparagine	0-12	ornithine decarboxylase 1	Rattus norvegicus	64-87
8743562-7	1996	The N-terminal amino acid sequence of MTSP-1 was Ile-Val-Gly-Gly-Tyr-Thr-His-Leu-Asp-Asn-Gln-Val-Pro-Tyr.	Asparagine	85-88	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	38-44
8626468-12	1996	3) The three potential sites of N-glycosylation at Asn-300, Asn-407, and Asn-534 are all utilized and contribute to intracellular stability of gp63.	Asparagine	51-54	leishmanolysin like peptidase	Homo sapiens	143-147
8626468-12	1996	3) The three potential sites of N-glycosylation at Asn-300, Asn-407, and Asn-534 are all utilized and contribute to intracellular stability of gp63.	Asparagine	60-63	leishmanolysin like peptidase	Homo sapiens	143-147
8626468-12	1996	3) The three potential sites of N-glycosylation at Asn-300, Asn-407, and Asn-534 are all utilized and contribute to intracellular stability of gp63.	Asparagine	60-63	leishmanolysin like peptidase	Homo sapiens	143-147
8626468-13	1996	4) Substitution of Asn-577 causes release of all mutant products, indicative of its specificity as a glycosyl phosphatidylinositol addition site for membrane anchoring of gp63.	Asparagine	19-22	leishmanolysin like peptidase	Homo sapiens	171-175
9156522-2	1996	However, they differ significantly at their carboxy terminals, i.e. the mouse TRH-R ends with an asparagine at position 393 while, in the rat, residue 393 is lysine and an additional 19 amino acids are added before the first stop codon.	Asparagine	97-107	thyrotropin releasing hormone receptor	Mus musculus	78-83
8615762-3	1996	PC8 possessed the catalytically important Asp, His, Asn and Ser amino acids, the homo B domain of this family of enzymes and a C-terminal hydrophobic sequence indicative of a transmembrane domain.	Asparagine	52-55	proprotein convertase subtilisin/kexin type 7	Homo sapiens	0-3
8624437-3	1996	Many aquaporins are mercury sensitive, and in AQP1, a mercury-sensitive cysteine residue (Cys-189) is present adjacent to a conserved Asn-Pro-Ala motif.	Asparagine	134-137	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
8773318-3	1996	DPB1*6001, found in two individuals, contains a single nucleotide change that results in a polar amino acid, asparagine, at residue 65; this position in the beta 1 domain is occupied by a nonpolar amino acid in all other reported DPB1 alleles.	Asparagine	109-119	major histocompatibility complex, class II, DP beta 1	Homo sapiens	0-4
8773318-3	1996	DPB1*6001, found in two individuals, contains a single nucleotide change that results in a polar amino acid, asparagine, at residue 65; this position in the beta 1 domain is occupied by a nonpolar amino acid in all other reported DPB1 alleles.	Asparagine	109-119	major histocompatibility complex, class II, DP beta 1	Homo sapiens	230-234
8901136-5	1996	In the XiamenUF allele it is a substitution of lysine (AAA) to asparagine (AAT) in exon 1 (residue 3).	Asparagine	63-73	stress-sensitive B	Drosophila melanogaster	75-78
8737716-1	1996	OBJECTIVE: Serum alpha 1-antitrypsin (alpha 1AT) is an acute-phase glycoprotein which contains three carbohydrate side chains, N-glycosidically linked to the asparagine molecules (Asn46, Asn83 and Asn247) of the single polypeptide unit.	Asparagine	158-168	serpin family A member 1	Homo sapiens	17-36
8737716-1	1996	OBJECTIVE: Serum alpha 1-antitrypsin (alpha 1AT) is an acute-phase glycoprotein which contains three carbohydrate side chains, N-glycosidically linked to the asparagine molecules (Asn46, Asn83 and Asn247) of the single polypeptide unit.	Asparagine	158-168	serpin family A member 1	Homo sapiens	38-47
8615773-2	1996	We report that these cells, when exposed to thrombin or SFLLRN (the peptide Ser-Phe-Leu-Leu-Arg-Asn, a thrombin-receptor ligand) rapidly change shape, forming membrane "blebs", detectable by differential interference contrast or confocal microscopy, as well as labelled 3-phosphorylated phosphoinositides.	Asparagine	96-99	coagulation factor II, thrombin	Homo sapiens	44-52
8615773-2	1996	We report that these cells, when exposed to thrombin or SFLLRN (the peptide Ser-Phe-Leu-Leu-Arg-Asn, a thrombin-receptor ligand) rapidly change shape, forming membrane "blebs", detectable by differential interference contrast or confocal microscopy, as well as labelled 3-phosphorylated phosphoinositides.	Asparagine	96-99	coagulation factor II, thrombin	Homo sapiens	103-111
8815211-9	1996	Mutation of the N-site asparagine (N) to glutamine (Q) at homologous positions in either NR1 (position 598) or NR2A (position 595) increased the permeability of DMA relative to wild-type channels about equally.	Asparagine	23-33	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	89-92
8815211-9	1996	Mutation of the N-site asparagine (N) to glutamine (Q) at homologous positions in either NR1 (position 598) or NR2A (position 595) increased the permeability of DMA relative to wild-type channels about equally.	Asparagine	23-33	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	111-115
8815211-13	1996	Channels in which the NR1 N-site asparagine was replaced by the smaller glycine (G), NR1(N598G)-NR2A, showed the largest increase in pore size of all sites examined in either subunit.	Asparagine	33-43	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	22-25
8815211-16	1996	For the NR2A-subunit, an asparagine residue (position 596) on the C-terminal side of the N-site, when mutated to larger or smaller sized amino acids, produced large, volume-specific effects on pore size.	Asparagine	25-35	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	8-12
8815211-24	1996	It is concluded that both the NR1- and NR2A-subunits contribute to the narrow constriction of NMDA receptor channels with asparagines located at non-homologous positions.	Asparagine	122-133	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	30-33
8815211-24	1996	It is concluded that both the NR1- and NR2A-subunits contribute to the narrow constriction of NMDA receptor channels with asparagines located at non-homologous positions.	Asparagine	122-133	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	39-43
8815211-24	1996	It is concluded that both the NR1- and NR2A-subunits contribute to the narrow constriction of NMDA receptor channels with asparagines located at non-homologous positions.	Asparagine	122-133	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	94-107
8815211-25	1996	The major determinants of the narrow constriction in NMDA receptor channels are the NR1 N-site asparagine and an asparagine adjacent to the NR2A N-site.	Asparagine	95-105	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-66
8815211-25	1996	The major determinants of the narrow constriction in NMDA receptor channels are the NR1 N-site asparagine and an asparagine adjacent to the NR2A N-site.	Asparagine	95-105	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	84-87
8815211-25	1996	The major determinants of the narrow constriction in NMDA receptor channels are the NR1 N-site asparagine and an asparagine adjacent to the NR2A N-site.	Asparagine	113-123	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-66
8815211-25	1996	The major determinants of the narrow constriction in NMDA receptor channels are the NR1 N-site asparagine and an asparagine adjacent to the NR2A N-site.	Asparagine	113-123	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	140-144
8852659-6	1996	We have identified two novel EDNRB mutations: a missense mutation in a sporadic case, S305N, which leads to a change of a serine to an asparagine, disrupting a putative phosphorylation site; and a single nucleotide deletion in a familial case, N378I, resulting in a truncated protein.	Asparagine	135-145	endothelin receptor type B	Homo sapiens	29-34
8786069-5	1996	The Moslem Arabs were homozygous for two mutations in the GALC gene; a T-to-C transition at CDNA position 1637 (counting from the A of the initiation codon), which is considered a polymorphism and a G-to-A transition at position 1582, which changes the codon for aspartic acid to one for asparagine.	Asparagine	288-298	galactosylceramidase	Homo sapiens	58-62
8901136-6	1996	An asparagine (AAT) to aspartate (GAT) change was found in exon 6 (residue 336) in the IowaUF and NetherlandsUF alleles.	Asparagine	3-13	stress-sensitive B	Drosophila melanogaster	15-18
8901136-6	1996	An asparagine (AAT) to aspartate (GAT) change was found in exon 6 (residue 336) in the IowaUF and NetherlandsUF alleles.	Asparagine	3-13	GABA transporter	Drosophila melanogaster	34-37
8617760-9	1996	The active domain of Atp11p was mapped to the sequence between Phe-120 and Asn-174.	Asparagine	75-78	Atp11p	Saccharomyces cerevisiae S288C	21-27
8617744-6	1996	Alteration of the Asn or Pro to Ala in the NPXpY motif of the EGFR Tyr-1148 peptide increased the KD of PI domain interactions to 238 and 370 nM, respectively.	Asparagine	18-21	epidermal growth factor receptor	Homo sapiens	62-66
8639654-2	1996	The functional role of N-linked carbohydrates in the human vasoactive intestinal peptide (VIP) 1 receptor was investigated by site-directed mutagenesis (Asn--&gt;Thr) of the four consensus N-glycosylation sites on Asn58, Asn69, Asn100 (N-terminal extracellular domain) and Asn293 (second extracellular loop).	Asparagine	153-156	vasoactive intestinal peptide	Homo sapiens	90-93
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Asparagine	47-50	fibroblast growth factor 2	Homo sapiens	163-172
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Asparagine	47-50	fibroblast growth factor 2	Homo sapiens	174-178
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Asparagine	47-50	fibroblast growth factor 1	Bos taurus	246-250
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	66-69	intercellular adhesion molecule 1	Homo sapiens	109-115
8868475-8	1996	To experimentally address the putative homology of ERGIC-53 to leguminous lectins, a highly conserved protein family with an invariant asparagine essential for carbohydrate binding, we substituted the corresponding asparagine in ERGIC-53.	Asparagine	135-145	lectin, mannose binding 1	Homo sapiens	51-59
8868475-8	1996	To experimentally address the putative homology of ERGIC-53 to leguminous lectins, a highly conserved protein family with an invariant asparagine essential for carbohydrate binding, we substituted the corresponding asparagine in ERGIC-53.	Asparagine	215-225	lectin, mannose binding 1	Homo sapiens	51-59
8868475-8	1996	To experimentally address the putative homology of ERGIC-53 to leguminous lectins, a highly conserved protein family with an invariant asparagine essential for carbohydrate binding, we substituted the corresponding asparagine in ERGIC-53.	Asparagine	215-225	lectin, mannose binding 1	Homo sapiens	229-237
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	66-69	intercellular adhesion molecule 1	Homo sapiens	152-158
8639667-5	1996	Asn-379, located between the D4 and D5 domains, is believed to be located close to the membrane surface in membrane bound ICAM-1.	Asparagine	0-3	intercellular adhesion molecule 1	Homo sapiens	122-128
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	66-69	integrin subunit alpha M	Homo sapiens	162-167
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	78-81	intercellular adhesion molecule 1	Homo sapiens	109-115
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	78-81	intercellular adhesion molecule 1	Homo sapiens	152-158
8551601-2	1996	Sequence analysis of viral DNA derived from long-term cultures of Jurkat cells revealed a specific mutation that changed a highly conserved Asn residue in the V1 loop of Env to an Asp residue (N-136--&gt;D).	Asparagine	140-143	endogenous retrovirus group W member 1, envelope	Homo sapiens	170-173
8639667-6	1996	It has been proposed that the extent of N-linked glycosylation at Asn-240 and Asn-269 in the third domain of ICAM-1 may regulate the binding avidity of ICAM-1 to Mac-1 [Diamond, M. S., Staunton, D. E., Marlin, S. D., &amp; Springer, T. A.	Asparagine	78-81	integrin subunit alpha M	Homo sapiens	162-167
8745430-0	1996	HB Hinwil or beta 38(C4)Thr-->Asn: a new beta chain variant detected in a Swiss family.	Asparagine	30-33	complement C4A (Rodgers blood group)	Homo sapiens	13-23
24203237-0	1996	Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis beta77(EF1) His   Tyr, beta 80 (EF4) Asn   Ser.	Asparagine	184-187	GTP binding elongation factor GUF1	Homo sapiens	179-182
8636646-5	1996	Interestingly, when Gln and Asn located at positions 15 and 24, respectively, of the PF4 C-terminal region were replaced by Glu and Asp (C13-24DE), an increase in the inhibitory activity was observed.	Asparagine	28-31	platelet factor 4	Homo sapiens	85-88
8576196-6	1996	Exchange of Asn-312 and Leu-311 in the beta 2 adrenoceptor resulted in nonfunctional proteins, most likely due to incompatibility of the introduced bulky phenylalanine side chain with adjacent structural domains in the beta 2 adrenoreceptor.	Asparagine	12-15	adrenoceptor beta 2	Homo sapiens	39-58
8576196-6	1996	Exchange of Asn-312 and Leu-311 in the beta 2 adrenoceptor resulted in nonfunctional proteins, most likely due to incompatibility of the introduced bulky phenylalanine side chain with adjacent structural domains in the beta 2 adrenoreceptor.	Asparagine	12-15	adrenoceptor beta 2	Homo sapiens	219-240
8577769-4	1996	Analysis of individual residues within this motif indicates that the Asn at position -3 [with respect to Tyr(P)], in addition to Tyr(P), is critical for PTB binding, while the Pro at position -2 plays a less significant role.	Asparagine	69-72	polypyrimidine tract binding protein 1	Homo sapiens	153-156
8780172-4	1996	The extent to which glycosylation of the 75 asparagine site affects the angiogenic properties of VEGF/VPF has not been studied in vivo.	Asparagine	44-54	vascular endothelial growth factor A	Bos taurus	97-101
8780172-4	1996	The extent to which glycosylation of the 75 asparagine site affects the angiogenic properties of VEGF/VPF has not been studied in vivo.	Asparagine	44-54	vascular endothelial growth factor A	Bos taurus	102-105
8981016-3	1996	In the cognate variant TR beta (TR beta-CN) amino acid codon 322 was exchanged from aspartic acid to asparagine.	Asparagine	101-111	T cell receptor beta locus	Homo sapiens	23-30
8780172-10	1996	Tryptic mapping by reverse-phase HPLC confirmed that the potential glycosylation site at 75 asparagine was occupied by N-linked carbohydrate for the Chinese hamster ovary-derived VEGF/VPF, but not for E. coli-derived VEGF/VPF.	Asparagine	92-102	vascular endothelial growth factor A	Bos taurus	179-183
8780172-10	1996	Tryptic mapping by reverse-phase HPLC confirmed that the potential glycosylation site at 75 asparagine was occupied by N-linked carbohydrate for the Chinese hamster ovary-derived VEGF/VPF, but not for E. coli-derived VEGF/VPF.	Asparagine	92-102	vascular endothelial growth factor A	Bos taurus	184-187
8780172-10	1996	Tryptic mapping by reverse-phase HPLC confirmed that the potential glycosylation site at 75 asparagine was occupied by N-linked carbohydrate for the Chinese hamster ovary-derived VEGF/VPF, but not for E. coli-derived VEGF/VPF.	Asparagine	92-102	vascular endothelial growth factor A	Bos taurus	217-221
8780172-10	1996	Tryptic mapping by reverse-phase HPLC confirmed that the potential glycosylation site at 75 asparagine was occupied by N-linked carbohydrate for the Chinese hamster ovary-derived VEGF/VPF, but not for E. coli-derived VEGF/VPF.	Asparagine	92-102	vascular endothelial growth factor A	Bos taurus	222-225
8868303-1	1996	We have synthesized eight analogues of the linear vasopressin antagonist DTyr(Et)2-Phe3-Gln4-Asn5-Arg6-Pro7-Arg8-Tyr(NH2)9 substituted with L-, or D-, pyroglutamate at position-1, Asn or Val at position-4 and Arg or Met at position 6.	Asparagine	93-96	arginine vasopressin	Homo sapiens	50-61
8543840-10	1996	Thus, the naturally processed form of an env epitope containing an N-linked glycosylation site is derived from env protein that is not glycosylated at the relevant asparagine during biosynthesis.	Asparagine	164-174	endogenous retrovirus group K member 20	Homo sapiens	41-44
8543840-10	1996	Thus, the naturally processed form of an env epitope containing an N-linked glycosylation site is derived from env protein that is not glycosylated at the relevant asparagine during biosynthesis.	Asparagine	164-174	endogenous retrovirus group K member 20	Homo sapiens	111-114
8719119-3	1996	Some patients have both nucleotides C and T at position 1080 in 5HT1D alpha receptor gene; however, both of them code the same amino acid, asparagine.	Asparagine	139-149	5-hydroxytryptamine receptor 1D	Homo sapiens	64-75
8570625-9	1996	The side-chain pockets and conserved asparagine residues of the DR1 molecule are well-positioned to interact with peptides in the polyproline type II conformation and may restrict the range of acceptable peptide conformations.	Asparagine	37-47	down-regulator of transcription 1	Homo sapiens	64-67
8805224-5	1996	RESULTS: A dominant-negative mutant of the small GTP-binding protein Rac (Rac N17, containing an asparagine residue at position 17) was found to block v-Abl-induced activation of two mitogenic enhancer elements.	Asparagine	97-107	AKT serine/threonine kinase 1	Homo sapiens	69-72
8805224-5	1996	RESULTS: A dominant-negative mutant of the small GTP-binding protein Rac (Rac N17, containing an asparagine residue at position 17) was found to block v-Abl-induced activation of two mitogenic enhancer elements.	Asparagine	97-107	AKT serine/threonine kinase 1	Homo sapiens	74-77
8805224-5	1996	RESULTS: A dominant-negative mutant of the small GTP-binding protein Rac (Rac N17, containing an asparagine residue at position 17) was found to block v-Abl-induced activation of two mitogenic enhancer elements.	Asparagine	97-107	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	151-156
8981016-3	1996	In the cognate variant TR beta (TR beta-CN) amino acid codon 322 was exchanged from aspartic acid to asparagine.	Asparagine	101-111	T cell receptor beta locus	Homo sapiens	32-39
9007616-4	1996	DNA sequence analysis of the LCAT gene showed an A-to-T transition at base 97 in exon 1, and predicted a change in asparagine to isoleucine at the 5th amino acid of the protein.	Asparagine	115-125	lecithin-cholesterol acyltransferase	Homo sapiens	29-33
8664898-6	1996	Substitution of a basic amino acid for asparagine at residue 47, conserved in all known murine Pax and human PAX genes, appears to have a more drastic effect on the phenotype than missense, frameshift and deletion mutations of PAX3 that cause Waardenburg syndrome type 1.	Asparagine	39-49	paxillin	Mus musculus	95-98
8664898-6	1996	Substitution of a basic amino acid for asparagine at residue 47, conserved in all known murine Pax and human PAX genes, appears to have a more drastic effect on the phenotype than missense, frameshift and deletion mutations of PAX3 that cause Waardenburg syndrome type 1.	Asparagine	39-49	paxillin	Mus musculus	109-112
8825075-2	1995	Several recent studies have linked a previously reported substitution, N314D (asn to asp at position 314), with both the Duarte and Los Angeles (LA) variant alleles of GALT.	Asparagine	78-81	galactose-1-phosphate uridylyltransferase	Homo sapiens	168-172
8569707-4	1996	A modification of a previously described 5-HT1D beta receptor graphic model was mutated by replacement of T355 with asparagine.	Asparagine	116-126	5-hydroxytryptamine receptor 1B	Homo sapiens	41-52
8844764-1	1996	The peptide, Phe-Gly Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH, recently isolated from rat brain, has been suggested to be an endogenous agonist for an orphan, opioid-like receptor (ORL1).	Asparagine	69-72	opioid related nociceptin receptor 1	Rattus norvegicus	199-203
8537403-3	1995	The protein kinase domains of LIMK1 and LIMK2 are unique in that they contain an unusual sequence motif Asp-Leu-Asn-Ser-His-Asn in subdomain VIB and a highly basic insert between subdomains VII and VIII.	Asparagine	112-115	LIM domain kinase 1	Homo sapiens	30-35
8537403-3	1995	The protein kinase domains of LIMK1 and LIMK2 are unique in that they contain an unusual sequence motif Asp-Leu-Asn-Ser-His-Asn in subdomain VIB and a highly basic insert between subdomains VII and VIII.	Asparagine	112-115	LIM domain kinase 2	Homo sapiens	40-45
7499849-7	1995	These mutants both contained amino acid substitutions from Asn to Ser or Thr at VH CDR1 position 35, a putative Ars contact residue.	Asparagine	59-62	cerebellar degeneration related protein 1	Homo sapiens	83-87
9383482-3	1995	A polypeptide representing the relevant sequence from the alpha-subunit of the nAChR (Ac-Tyr-Cys-Glu-Ile-Ile-Val-Thr-His-Phe-Pro-Phe-Asp-Gln-Gln Asn-Cys-Thr-NH2) is small enough to allow detailed structural analysis, which may provide insight into the role of glycosylation in the maturation process that leads to ion-channel assembly.	Asparagine	145-148	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	79-84
8770386-2	1995	Treatment of delipidated hen egg yolk with the protease Orientase and neuraminidase gave a dimeric N-acetyllactosamine-containing oligosaccharide linked to asparagine.	Asparagine	156-166	neuraminidase 1	Homo sapiens	70-83
8772226-10	1995	By removing N-linked sugars with N-glycanase, it could be demonstrated that the difference between the two forms of HRG is caused by an extra carbohydrate group at Asn 184 in form 1.	Asparagine	164-167	histidine rich glycoprotein	Homo sapiens	116-119
8544395-3	1995	The other modifications in beta 2m from amyloid deposits are partial proteolysis and single amino acid replacement (Asn by ASp at position 17).	Asparagine	116-119	beta-2-microglobulin	Homo sapiens	27-34
7559574-6	1995	Based on the amino acid sequence of phosphacan, it can be concluded that each of the tryptic peptides contains one potential N-glycosylation site (at Asn-232 and Asn-381), and analyses of the isolated glycopeptides demonstrated the presence of sialylated complex-type oligosaccharides.	Asparagine	150-153	protein tyrosine phosphatase receptor type Z1	Homo sapiens	36-46
7590343-8	1995	The two Asn-linked glycosylation sites found in chicken RfBP are conserved in turtle RfBP, but only one of which is conserved in FBP.	Asparagine	8-11	riboflavin binding protein	Gallus gallus	56-60
7485512-0	1995	L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line.	Asparagine	16-28	ornithine decarboxylase 1	Sus scrofa	39-42
7559482-9	1995	Examination of additional IL-8-based mutants in the colony formation assay, which centered on the perturbation of the amino-terminal "ELR" motif, resulted in the observation that the highly active IL-8 mutant required both aspartic acid at amino acid residue 4 and either glutamine or asparagine at residue 6.	Asparagine	285-295	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
7592613-3	1995	Using strategies based upon fast atom bombardment and electrospray mass spectrometry we have established that glycodelin is glycosylated at Asn-28 and Asn-63.	Asparagine	140-143	progestagen associated endometrial protein	Homo sapiens	110-120
7592613-3	1995	Using strategies based upon fast atom bombardment and electrospray mass spectrometry we have established that glycodelin is glycosylated at Asn-28 and Asn-63.	Asparagine	151-154	progestagen associated endometrial protein	Homo sapiens	110-120
7583546-0	1995	Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291--&gt;Ser mutation in the human LPL gene.	Asparagine	118-121	apolipoprotein E	Homo sapiens	14-19
7573038-1	1995	We present evidence that a 480G--&gt;A transition in the coding region of the beta-glucuronidase gene, which results in an aspartic-acid-to-asparagine substitution at amino acid position 152 (D152N), produces a pseudodeficiency allele (GUSBp) that leads to greatly reduced levels of beta-glucuronidase activity without apparent deleterious consequences.	Asparagine	140-150	glucuronidase beta	Homo sapiens	78-96
7573038-1	1995	We present evidence that a 480G--&gt;A transition in the coding region of the beta-glucuronidase gene, which results in an aspartic-acid-to-asparagine substitution at amino acid position 152 (D152N), produces a pseudodeficiency allele (GUSBp) that leads to greatly reduced levels of beta-glucuronidase activity without apparent deleterious consequences.	Asparagine	140-150	glucuronidase beta	Homo sapiens	236-241
7573038-1	1995	We present evidence that a 480G--&gt;A transition in the coding region of the beta-glucuronidase gene, which results in an aspartic-acid-to-asparagine substitution at amino acid position 152 (D152N), produces a pseudodeficiency allele (GUSBp) that leads to greatly reduced levels of beta-glucuronidase activity without apparent deleterious consequences.	Asparagine	140-150	glucuronidase beta	Homo sapiens	283-301
7583546-0	1995	Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291--&gt;Ser mutation in the human LPL gene.	Asparagine	118-121	transcription factor 4	Homo sapiens	32-42
7583546-0	1995	Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291--&gt;Ser mutation in the human LPL gene.	Asparagine	118-121	lipoprotein lipase	Homo sapiens	157-160
7583546-5	1995	As a first step, we performed DNA sequence analysis of all 10 LPL coding exons in 2 patients with the apoE2/2 genotype who had type III hyperlipoproteinemia and identified a single missense mutation (Asn 291--&gt;Ser) in exon 6 of the LPL gene.	Asparagine	200-203	lipoprotein lipase	Homo sapiens	62-65
7583546-5	1995	As a first step, we performed DNA sequence analysis of all 10 LPL coding exons in 2 patients with the apoE2/2 genotype who had type III hyperlipoproteinemia and identified a single missense mutation (Asn 291--&gt;Ser) in exon 6 of the LPL gene.	Asparagine	200-203	apolipoprotein E	Homo sapiens	102-109
7583546-5	1995	As a first step, we performed DNA sequence analysis of all 10 LPL coding exons in 2 patients with the apoE2/2 genotype who had type III hyperlipoproteinemia and identified a single missense mutation (Asn 291--&gt;Ser) in exon 6 of the LPL gene.	Asparagine	200-203	lipoprotein lipase	Homo sapiens	235-238
7583546-8	1995	In vitro mutagenesis studies revealed that the Asn 291--&gt;Ser mutant LPL had approximately 60% of LPL catalytic activity and approximately 70% of specific activity compared with wild-type LPL.	Asparagine	47-50	lipoprotein lipase	Homo sapiens	71-74
7583546-8	1995	In vitro mutagenesis studies revealed that the Asn 291--&gt;Ser mutant LPL had approximately 60% of LPL catalytic activity and approximately 70% of specific activity compared with wild-type LPL.	Asparagine	47-50	lipoprotein lipase	Homo sapiens	100-103
7583546-8	1995	In vitro mutagenesis studies revealed that the Asn 291--&gt;Ser mutant LPL had approximately 60% of LPL catalytic activity and approximately 70% of specific activity compared with wild-type LPL.	Asparagine	47-50	lipoprotein lipase	Homo sapiens	100-103
7583546-10	1995	Our data suggest that the Asn 291--&gt;Ser substitution is likely to be a significant predisposing factor contributing to the expression of different forms of hyperlipidemia when associated with other genetic factors such as the presence of apoE2.	Asparagine	26-29	apolipoprotein E	Homo sapiens	241-246
7568109-2	1995	Further studies have shown that an additional 6 residues in the rAT1b receptor TMs II (Ala-73), III (Ser-109, Ala-114, Ser-115), VI (Phe-248), and VII (Asn-295) are important in Losartan binding.	Asparagine	152-155	angiotensin II receptor, type 1b	Rattus norvegicus	64-69
8647397-8	1995	In sca(UM2), an invariant Asp residue is replaced by Asn.	Asparagine	53-56	scabrous	Drosophila melanogaster	3-6
8576637-0	1995	Interaction of the lipoprotein lipase asparagine 291--&gt;serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults.	Asparagine	38-48	lipoprotein lipase	Homo sapiens	19-37
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Asparagine	92-103	cerebellar degeneration related antigen 1	Mus musculus	107-111
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-65
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-76
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	CD28 molecule	Homo sapiens	91-95
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	183-186
7665562-5	1995	PC2 with the potential oxyanion hole Asp residue changed to Asn was processed and altered several aspects of POMC processing in a manner similar to that of wild-type PC2.	Asparagine	60-63	proprotein convertase subtilisin/kexin type 2	Homo sapiens	0-3
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Asparagine	92-103	cerebellar degeneration-related 2	Mus musculus	115-119
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	growth factor receptor bound protein 2	Homo sapiens	216-221
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	CD28 molecule	Homo sapiens	237-241
8572580-1	1995	Basal level of asparagine synthetase mRNA in BALB3T3 cells was elevated when the cells were shifted from medium containing a high concentration (3.3 mM) of asparagine to one lacking asparagine.	Asparagine	156-166	asparagine synthetase	Mus musculus	15-36
7670940-6	1995	In the Finnish population, allele frequencies of the rare alleles of the apoB 1887 (Asn-->Ser) and apoB 1896 (His-->Arg) polymorphisms were .02 and .11, respectively.	Asparagine	84-87	apolipoprotein B	Homo sapiens	73-77
8527802-1	1995	Heterozygous missense mutation in codon 15 of the rhodopsin gene was detected in a patient with autosomal dominant retinitis pigmentosa (ADRP), where a transition of adenine to guanine at the second nucleotide in codon 15 (AAT--&gt;AGT), corresponding to a substitution of serine residue for asparagine residue (Asn-15-Ser) was detected.	Asparagine	292-302	rhodopsin	Homo sapiens	50-59
8548867-3	1995	The cell adhesive region in the central portion of fibronectin is comprised of at least two minimal amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence--which function in synergy.	Asparagine	174-177	fibronectin 1	Homo sapiens	51-62
7544576-2	1995	The histamine H2 receptor is a member of the family of G-protein-coupled receptors, and has three extracellular potential sites for N-glycosylation (Asn-4, Asn-162 and Asn-168).	Asparagine	149-152	histamine H2 receptor	Cricetulus griseus	4-25
7544576-2	1995	The histamine H2 receptor is a member of the family of G-protein-coupled receptors, and has three extracellular potential sites for N-glycosylation (Asn-4, Asn-162 and Asn-168).	Asparagine	156-159	histamine H2 receptor	Cricetulus griseus	4-25
7544576-2	1995	The histamine H2 receptor is a member of the family of G-protein-coupled receptors, and has three extracellular potential sites for N-glycosylation (Asn-4, Asn-162 and Asn-168).	Asparagine	156-159	histamine H2 receptor	Cricetulus griseus	4-25
7638622-3	1995	A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds.	Asparagine	80-90	presenilin 2	Homo sapiens	20-24
8589524-3	1995	The difference at amino acid residue 94, (Gpi1-sa GAT Asp, Gpi1-sb AAT Asn) may account for the differing electrophoretic migration, isoelectric point, and thermostability of the two alleles.	Asparagine	71-74	glucose-6-phosphate isomerase 1	Mus musculus	42-46
7654761-8	1995	N-Terminal amino acid sequencing showed that the 43K c-mos protein has a Asp-Glu-Gly-Gly-Asn-Leu-Gln-sequence located 5" upstream (99 bases upstream) of the rat c-mos coding sequence reported.	Asparagine	89-92	MOS proto-oncogene, serine/threonine kinase	Rattus norvegicus	53-58
7629517-3	1995	The previously defined NK clones belonging to "group 1" recognize HLA-C*0401 (Cw4) and other HLA-C alleles sharing Asn at position 77 and Lys at position 80.	Asparagine	115-118	major histocompatibility complex, class I, C	Homo sapiens	93-98
7496154-3	1995	In this study, we show that the oligosaccharide side chains on autotaxin are exclusively asparagine linked, since N-glycosidase F, but not neuraminidase or O-glycosidase, decreases the protein molecular mass to 100-105kD, which is the calculated molecular mass of the deduced autotaxin polypeptide.	Asparagine	89-99	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	63-72
8589524-3	1995	The difference at amino acid residue 94, (Gpi1-sa GAT Asp, Gpi1-sb AAT Asn) may account for the differing electrophoretic migration, isoelectric point, and thermostability of the two alleles.	Asparagine	71-74	glucose-6-phosphate isomerase 1	Mus musculus	59-63
8527930-9	1995	N-glycosidase treatment indicates that each PEDF molecule has a 5% carbohydrate content attached to internal asparagine residue(s).	Asparagine	109-119	LOC100337325	Bos taurus	44-48
7494806-1	1995	PURPOSE: In the pH range 2-5, human insulin degrades via deamidation at the A-21 asn and covalent dimerization.	Asparagine	81-84	insulin	Homo sapiens	36-43
7628611-4	1995	Of particular interest, Asn-265, a residue located between two putative membrane spanning regions of the frog KBP, is a functional N-glycosylation site.	Asparagine	24-27	kinesin family binding protein	Homo sapiens	110-113
7545493-8	1995	This 3 bp deletion (AAC) in exon 1 of K6a removes a highly conserved asparagine residue (delta N170) from position 8 of the 1A helical domain (delta N8).	Asparagine	69-79	keratin 6A	Homo sapiens	38-41
7791792-3	1995	This mutation changes an evolutionarily conserved aspartic acid to asparagine within the autoinhibitory domain of the calcineurin A alpha protein.	Asparagine	67-77	protein phosphatase 3, catalytic subunit, alpha isoform	Mus musculus	118-137
7599134-0	1995	Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity.	Asparagine	42-52	serpin family C member 1	Homo sapiens	25-41
7599134-0	1995	Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity.	Asparagine	42-52	serpin family C member 1	Homo sapiens	191-207
7599134-2	1995	The alpha-ATIII isoform has four N-linked oligosaccharides attached to asparagines 96, 135, 155, and 192.	Asparagine	71-82	serpin family C member 1	Homo sapiens	10-15
7599134-3	1995	The beta-ATIII isoform lacks carbohydrate on asparagine-135 (N135), which is near the heparin binding site, and binds heparin with higher affinity than does alpha-ATIII.	Asparagine	45-55	serpin family C member 1	Homo sapiens	9-14
7616440-7	1995	In cultured IEC-6 cells, cimetidine caused a linear and significant inhibition of the stimulation of ODC activity in response to pentagastrin, EGF, 5% dialyzed fetal bovine serum (FBS) and asparagine.	Asparagine	189-199	ornithine decarboxylase 1	Rattus norvegicus	101-104
7616440-8	1995	ODC messenger RNA (mRNA) levels in IEC-6 cells were significantly increased after exposure to 5% dialyzed FBS and asparagine.	Asparagine	114-124	ornithine decarboxylase 1	Rattus norvegicus	0-3
7616440-9	1995	Although cimetidine almost completely prevented the induction of ODC activity in IEC-6 cells exposed to serum or asparagine, the increases in ODC mRNA levels were not inhibited by the compound.	Asparagine	113-123	ornithine decarboxylase 1	Rattus norvegicus	65-68
7779775-10	1995	On the other hand, the mutants of Gln-4 and Asn-6, which are located at or near the surface, displayed structural and kinetic properties similar to those of the wild-type PLA2 with the exception of the highly hydrophilic lysine mutant.	Asparagine	44-47	LOC104974671	Bos taurus	171-175
8590017-10	1995	CONCLUSIONS: These structures suggest that analogs to all or part of the pentapeptide Ala-Glu-Tyr-His-Asn, corresponding to residues 10-14 of CTB, may constitute lead compounds for the design of binding-site inhibitors.	Asparagine	102-105	phosphate cytidylyltransferase 1B, choline	Homo sapiens	142-145
7751635-6	1995	By a single Arg to Asn mutation, an N-linked glycosylation site similar to that of LL-2 was introduced in the FR-1 segment of a nonglycosylated, humanized anti-carcinoembryonic Ag (CEA) Ab, MN-14 (hMN-14).	Asparagine	19-22	peroxiredoxin 2, pseudogene 1	Mus musculus	83-87
7782780-1	1995	The role of the glycans of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) in the intracellular events of Env precursor (gp160) biosynthesis has been examined by the use of a mutant gp160 in which the cluster of conserved glycosylation sites within the gp41 domain (Asn-621, -630 and -642) has been mutated.	Asparagine	292-295	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	132-135
7773731-3	1995	In this study we re-created the FH3 mutation (Asp154--&gt;Asn) in exon 4 by site-directed mutagenesis and analyzed the expression of the mutant receptors in Chinese hamster ovary cells.	Asparagine	58-61	proprotein convertase subtilisin/kexin type 9	Homo sapiens	32-35
7774715-7	1995	Moreover, 70% of total glycans were alpha-1,6-fucosylated at the GlcNAc residue linked to asparagine.	Asparagine	90-100	adrenoceptor alpha 1D	Homo sapiens	36-43
7781780-1	1995	A sialidase resistant mono-charged N-glycan was isolated from glycosylation site I (Asn-24) of recombinant human erythropoietin expressed from baby hamster kidney (BHK-21) cells and constituted approximately 2-4% of the oligosaccharide material at this glycosylation site.	Asparagine	84-87	erythropoietin	Homo sapiens	113-127
7744875-4	1995	In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6.	Asparagine	62-65	interleukin 6	Homo sapiens	132-137
7744855-4	1995	We isolated a Saccharomyces cerevisiae gene, termed NTA1, that encodes an amidase (Nt-amidase) specific for N-terminal asparagine and glutamine.	Asparagine	119-129	amidase	Saccharomyces cerevisiae S288C	52-56
7744855-4	1995	We isolated a Saccharomyces cerevisiae gene, termed NTA1, that encodes an amidase (Nt-amidase) specific for N-terminal asparagine and glutamine.	Asparagine	119-129	amidase	Saccharomyces cerevisiae S288C	74-81
7619006-6	1995	The serum IgE level was lower in ASN.	Asparagine	33-36	immunoglobulin heavy constant epsilon	Homo sapiens	10-13
7744855-4	1995	We isolated a Saccharomyces cerevisiae gene, termed NTA1, that encodes an amidase (Nt-amidase) specific for N-terminal asparagine and glutamine.	Asparagine	119-129	amidase	Saccharomyces cerevisiae S288C	86-93
7744855-6	1995	Null nta1 mutants are viable but unable to degrade N-end rule substrates that bear N-terminal asparagine or glutamine.	Asparagine	94-104	amidase	Saccharomyces cerevisiae S288C	5-9
7755594-0	1995	N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance.	Asparagine	54-57	interferon gamma	Homo sapiens	25-41
7755594-1	1995	Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer.	Asparagine	159-162	interferon gamma	Homo sapiens	6-22
7755594-1	1995	Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer.	Asparagine	159-162	interferon gamma	Homo sapiens	24-33
7755594-1	1995	Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer.	Asparagine	170-173	interferon gamma	Homo sapiens	6-22
7755594-1	1995	Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer.	Asparagine	170-173	interferon gamma	Homo sapiens	24-33
7755594-6	1995	The glycan residues of IFN-gamma, especially at Asn-25, play an important role in protease resistance.	Asparagine	48-51	interferon gamma	Homo sapiens	23-32
7755594-9	1995	These results emphasize the importance of glycan residues, especially at Asn-25, in the proteolytic stability of human IFN-gamma.	Asparagine	73-76	interferon gamma	Homo sapiens	119-128
7648442-2	1995	Fibroblast-derived natural human interferon-beta is a glycoprotein having a single asparagine-linked sugar chain.	Asparagine	83-93	interferon beta 1	Homo sapiens	33-48
7492952-1	1995	It has been shown that supraphysiological concentrations of asparagine and hypoosmotic shock stimulate ornithine decarboxylase activity in cultured cancer cells by increasing the synthesis and the half-life of the enzyme protein.	Asparagine	60-70	ornithine decarboxylase 1	Rattus norvegicus	103-126
7658166-0	1995	Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment.	Asparagine	30-40	lipoprotein lipase	Homo sapiens	53-71
7713895-9	1995	The purified Asp-333--&gt;Asn mutant bound 6% of the substrate compared to the wild-type soluble epoxide hydrolase.	Asparagine	26-29	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-114
7658166-5	1995	An Ala residue was substituted for Asn at position 43 of the protein generating N43A hLPL.	Asparagine	35-38	lipoprotein lipase	Homo sapiens	85-89
7633183-4	1995	In this work, 22 different known TTR mutations were discriminated and studies on 210 samples from patients with peripheral neuropathies detected one polymorphic mutation (TTR Ser 6), TTR Asn 90, found previously in the normal Portuguese and German populations, and three other mutations, one of them TTR Ala 60.	Asparagine	187-190	transthyretin	Homo sapiens	33-36
7633183-4	1995	In this work, 22 different known TTR mutations were discriminated and studies on 210 samples from patients with peripheral neuropathies detected one polymorphic mutation (TTR Ser 6), TTR Asn 90, found previously in the normal Portuguese and German populations, and three other mutations, one of them TTR Ala 60.	Asparagine	187-190	transthyretin	Homo sapiens	171-174
7633183-4	1995	In this work, 22 different known TTR mutations were discriminated and studies on 210 samples from patients with peripheral neuropathies detected one polymorphic mutation (TTR Ser 6), TTR Asn 90, found previously in the normal Portuguese and German populations, and three other mutations, one of them TTR Ala 60.	Asparagine	187-190	transthyretin	Homo sapiens	171-174
7633183-4	1995	In this work, 22 different known TTR mutations were discriminated and studies on 210 samples from patients with peripheral neuropathies detected one polymorphic mutation (TTR Ser 6), TTR Asn 90, found previously in the normal Portuguese and German populations, and three other mutations, one of them TTR Ala 60.	Asparagine	187-190	transthyretin	Homo sapiens	171-174
7721851-7	1995	This set of tPA-specific PAI-1 mutants contained a wide range of amino acid substitutions at P1 including Asn, Gln, His, Ser, Thr, Leu, Met, and all the aromatic amino acids.	Asparagine	106-109	serpin family E member 1	Homo sapiens	25-30
7730377-3	1995	The roles of Ser-151 and Asn-166 as determinants of hexose affinity and cooperative behavior of human glucokinase have been evaluated by site-directed mutagenesis, expression and purification of the wild-type and mutant enzymes, and steady-state kinetic analysis.	Asparagine	25-28	glucokinase	Homo sapiens	102-113
7733658-3	1995	By site-directed mutagenesis, three mutant forms of recombinant guinea-pig liver transglutaminase, in which some acidic amino acid residues in two conserved regions became nonionic, were expressed in Escherichia coli: TGM1, with Asp-231 and -232 changed to Asn; TGM2, with Glu-445, -448, -449, -450, and -452 changed to Gln; and TGM3, with the mutations of both TGM1 and TGM2.	Asparagine	257-260	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	81-97
7592547-6	1995	We found that the yield of the beta form of the Asn137-to-Ala mutant (designated as sTF beta NNA) was threefold higher (3 mg/liter) than that of the wild type, suggesting that the replacement of one of the three potential N-glycosylation Asn residues with Ala could be a good way to minimize the addition of mannose repeats.	Asparagine	48-51	cystatin B	Homo sapiens	84-92
7641295-8	1995	Amino acid sequence of CBP-140 contains a carboxyl-terminal Asn-Asp-Glu-Leu (NDEL) sequence, which resembles Lys-Asp-Glu-Leu (KDEL) sequence, a signal to retain the resident proteins in endoplasmic reticulum; NDEL sequence may indeed play a similar role.	Asparagine	60-63	hypoxia up-regulated 1	Mus musculus	23-30
7753050-4	1995	Although feline CD9 appears most homologous to human CD9, it has two important features in common with bovine and murine CD9: the presence of a histidine residue at position 192 which is absent from the corresponding position (194) in human CD9; and the absence of two asparagine residues which are found at positions 51 and 52 of human CD9.	Asparagine	269-279	CD9 molecule	Homo sapiens	16-19
7533851-5	1995	The 8.7 variant exhibits a change in the epitope 32-42 (Val-35--&gt;Leu), and variant CL1.2 exhibits a change in the epitope 275-289 (Asn-280--&gt;Asp) of the wild-type LCMV-WE.	Asparagine	134-137	adhesion G protein-coupled receptor L1	Homo sapiens	86-89
9049325-4	1995	The first ORF encodes a 17 kDa PEST protein (p17) of unknown function while the second ORF encodes the 71 kDa coat protein precursor (p71) that is cleaved at an Asn-Phe site into the 64 kDa and 7 kDa coat proteins.	Asparagine	161-164	zinc finger protein 398	Homo sapiens	134-137
7718245-2	1995	The sensitivity for attenuation of desensitization by cyclothiazide for homomeric GluR-A was solely dependent upon exchange of Ser-750 (flip) and Asn-750 (flop), and was unaffected by mutagenesis of other divergent residues.	Asparagine	146-149	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	82-88
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Asparagine	62-65	troponin I3, cardiac type	Homo sapiens	38-43
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Asparagine	62-65	troponin I3, cardiac type	Homo sapiens	38-42
12228428-0	1995	Regulation of Nitrate Reductase during Early Seedling Growth (A Role for Asparagine and Glutamine).	Asparagine	73-83	nitrate reductase [NADH] 1	Zea mays	14-31
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Asparagine	62-65	troponin C1, slow skeletal and cardiac type	Homo sapiens	139-143
12228428-4	1995	Asparagine (1 mM) or glutamine (1 mM), potential products of that hydrolysis, inhibited the induction of NADH-dependent root NR in the dry system by about 70%.	Asparagine	0-10	nitrate reductase [NADH] 1	Zea mays	125-127
7896799-2	1995	Replacement of Asp-78 of both subunits with Glu, Ala, or Asn reduced dGK and dAK activities to less than 0.2%, whereas replacement of Arg-79 with Lys, either on both subunits in tandem (R79K), or on the dGK subunit only (R79K:dGK), yielded active but kinetically modified enzymes.	Asparagine	57-60	Diacyl glycerol kinase	Drosophila melanogaster	69-72
12228428-5	1995	The inhibition of the induction of NR activity in the wet system was only about 35%, suggesting that the enzyme in the wet system was already partially repressed at 3 d. At 5 d, when asparagine and glutamine levels in the plant tissue had decreased, the induction of root NR activity was inhibited to a similar extent in the two growth systems by amide additions.	Asparagine	183-193	nitrate reductase [NADH] 1	Zea mays	35-37
7697717-3	1995	In the UDG-6-aminouracil complex, uracil binds at the base of the groove within a rigid preformed pocket that confers selectivity for uracil over other bases by shape complementary and by main chain and Asn-204 side chain hydrogen bonds.	Asparagine	203-206	uracil DNA glycosylase	Homo sapiens	7-10
7896811-9	1995	MMP-7 can also activate proMMP-9 up to approximately 50% of the full activity with a new NH2 terminus of Leu16-Arg-Thr-(Asn)-Leu.	Asparagine	120-123	matrix metallopeptidase 7	Homo sapiens	0-5
7613486-1	1995	Asparagine-linked glycosylation of the insulin receptor is required for complete biosynthesis and acquisition of function.	Asparagine	0-10	insulin receptor	Homo sapiens	39-55
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Asparagine	81-84	angiogenin	Homo sapiens	47-50
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Asparagine	81-84	angiogenin	Homo sapiens	94-97
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Asparagine	125-131	T cell receptor alpha variable 6-3	Mus musculus	0-3
7534039-2	1995	We describe a family with an autosomal dominant skin-blistering disorder, epidermolysis bullosa simplex, Koebner subtype (EBS-K), that has a novel point mutation, occurring in the keratin 5 gene (KRT5), that predicts the substitution of an evolutionarily conserved lysine by an asparagine residue (K173N).	Asparagine	278-288	keratin 5	Homo sapiens	180-189
7534039-2	1995	We describe a family with an autosomal dominant skin-blistering disorder, epidermolysis bullosa simplex, Koebner subtype (EBS-K), that has a novel point mutation, occurring in the keratin 5 gene (KRT5), that predicts the substitution of an evolutionarily conserved lysine by an asparagine residue (K173N).	Asparagine	278-288	keratin 5	Homo sapiens	196-200
7876250-7	1995	Both human and rat NDF molecules are heavily glycosylated at two of the three potential Asn-linked glycosylation sites and contain O-linked sugars at 11 of the Thr/Ser sites.	Asparagine	88-91	neuregulin 1	Homo sapiens	19-22
7576485-6	1995	Most proteins that are translocated into the ER are glycosylated at Asn residues, and calnexin"s interactions are almost exclusively restricted to proteins that possess this posttranslational modification.	Asparagine	68-71	calnexin	Homo sapiens	86-94
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Asparagine	125-131	mammary tumor virus locus 7	Mus musculus	29-34
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Asparagine	125-131	T cell receptor alpha variable 6-3	Mus musculus	161-164
7629034-1	1995	The effects of additives on the nonenzymatic deamidation of an Asn residue in a peptide and racemization of Asp and/or Asn in lysozyme were investigated at pH 6 and 100 degrees C. These chemical reactions were accelerated by the addition of phosphate ions.	Asparagine	119-122	lysozyme	Homo sapiens	126-134
7780197-2	1995	Earlier studies demonstrated that the oligosaccharide at Asn-727 is vital for the production of fully active TfR.	Asparagine	57-60	transferrin receptor	Homo sapiens	109-112
7780197-6	1995	Glycosylation of Asn-727 found in the TfR purified from human placentae was analysed by high-pH anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) and mass spectrometry following tryptic digestion, peptide purification via reverse-phase high-performance liquid chromatography (RP-HPLC) and peptide sequencing.	Asparagine	17-20	transferrin receptor	Homo sapiens	38-41
7876141-7	1995	Castanospermine, which blocks trimming of glucose residues from asparagine-linked glycans, inhibited association of calnexin with heavy chains encoded by a second class I gene, HLA-B*0702.	Asparagine	64-74	calnexin	Homo sapiens	116-124
7616363-1	1995	The effects of pH and aniline trapping on the partitioning of the A-21 cyclic anhydride intermediate of human insulin into deamidated insulin and covalent dimer were investigated at low pH and 35 degrees C. Characterization of the covalent dimer was achieved by proteolytic cleavage and electrospray mass spectrometry and indicated that the deamidated A-21 asparagine of one insulin molecule and the B-1 phenylalanine residue of another are involved.	Asparagine	357-367	insulin	Homo sapiens	110-117
7862167-12	1995	Previous studies have indicated that activation of ERks in this cell line is dependent upon Ras since a dominant-negative Ras (Asn-17) blocks ERK activation by insulin.	Asparagine	127-130	Eph receptor B1	Rattus norvegicus	142-145
7532677-9	1995	Asparagine 86, the single site of N-linked glycosylation on class I molecules, is in close proximity to the Bw4/Bw6 region.	Asparagine	0-10	BW4	Homo sapiens	108-111
7532677-9	1995	Asparagine 86, the single site of N-linked glycosylation on class I molecules, is in close proximity to the Bw4/Bw6 region.	Asparagine	0-10	BW6	Homo sapiens	112-115
7852404-13	1995	Based on the crystal structure of cytochrome c we putatively assign the invariant Asn-52 (horse heart cytochrome c) as the site liganding the protonated phosphate of the lipid, whereas Lys-72 and -73 should bind the deprotonated form.	Asparagine	82-85	cytochrome c, somatic	Equus caballus	34-46
7852404-13	1995	Based on the crystal structure of cytochrome c we putatively assign the invariant Asn-52 (horse heart cytochrome c) as the site liganding the protonated phosphate of the lipid, whereas Lys-72 and -73 should bind the deprotonated form.	Asparagine	82-85	cytochrome c, somatic	Equus caballus	102-114
7848273-10	1995	Rat MIP26 cDNA contains an -Asn-Gly- sequence at the C-terminus, which has been shown in other proteins to be particularly susceptible to spontaneous deamidation [Takemoto and Emmons (1991) Curr.	Asparagine	28-31	major intrinsic protein of lens fiber	Rattus norvegicus	4-9
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	12-22	peroxiredoxin 2, pseudogene 1	Mus musculus	142-145
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	12-22	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	12-22	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	12-22	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	24-27	peroxiredoxin 2, pseudogene 1	Mus musculus	142-145
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	24-27	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	24-27	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-1	1995	A potential asparagine (Asn)-linked glycosylation site was identified in the VK FRI sequence of an anti-B lymphoma monoclonal antibody (MAb), LL2.SDS-PAGE analysis and endo-F treatment of both murine and chimeric LL2 antibodies indicated that this site was glycosylated; however, no differences in the binding affinity to Raji cells were observed between the native murine LL2 and the endo-F-deglycosylated murine LL2 antibodies.	Asparagine	24-27	peroxiredoxin 2, pseudogene 1	Mus musculus	213-216
7829269-2	1995	Elimination of the glycosylation site from the chimeric LL2 antibody was accomplished by an Asn to Gln mutation in the tri-acceptor site found in the light chain.	Asparagine	92-95	peroxiredoxin 2, pseudogene 1	Mus musculus	56-59
7848273-13	1995	We therefore modified the MIP26 molecule using a site-directed mutagenesis method to generate a mutant MIP26 at the appropriate asparagine residue (Asn244--&gt;Asp) near the C-terminus.	Asparagine	128-138	major intrinsic protein of lens fiber	Rattus norvegicus	26-31
7848273-13	1995	We therefore modified the MIP26 molecule using a site-directed mutagenesis method to generate a mutant MIP26 at the appropriate asparagine residue (Asn244--&gt;Asp) near the C-terminus.	Asparagine	128-138	major intrinsic protein of lens fiber	Rattus norvegicus	103-108
7865131-9	1995	The presence of potential processing multibasic sites suggests that small peptides could be generated (particularly a hexapeptide: Arg-Gln-His-Asn-Leu-Arg), as in the case of the SMR1-VA1 protein of R. norvegicus.	Asparagine	143-146	submaxillary gland androgen regulated protein 3B	Rattus norvegicus	179-183
7795154-0	1995	Two novel antithrombin variants, Asn187Asp and Asn187Lys, indicate a functional role for asparagine 187.	Asparagine	89-99	serpin family C member 1	Homo sapiens	10-22
7795154-3	1995	In two families the mutation (6460 AAC--&gt;GAC) results in an asparagine to aspartate substitution and is associated with normal immunological levels of antithrombin but a reduction in functional activity.	Asparagine	63-73	serpin family C member 1	Homo sapiens	154-166
7795154-5	1995	Asparagine 187 is located in the middle of the F helix of antithrombin and forms the major link between the F helix and strand 3 of the A sheet.	Asparagine	0-10	serpin family C member 1	Homo sapiens	58-70
7795417-0	1995	The asparagine-linked carbohydrate of honeybee venom hyaluronidase.	Asparagine	4-14	hyaluronidase	Apis mellifera	53-66
7768336-1	1995	The asparagine residues of the three N-glycosylation consensus sequences in the mouse gonadotropin-releasing hormone receptor were mutated to determine which residues were glycosylated and the function of glycosylation.	Asparagine	4-14	gonadotropin releasing hormone receptor	Mus musculus	86-125
7766415-4	1995	The antigenic molecule recognized by mAb EE2 was a novel glycoprotein with molecular weight of 114 kDa, which had affinity with Con A and WGA lectins, and was susceptible to N-glycanase, suggesting the presence of asparagine-linked sugar chains.	Asparagine	214-224	esterase 3	Mus musculus	41-44
7844595-0	1995	Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia.	Asparagine	10-22	colony stimulating factor 2	Homo sapiens	26-29
7844595-0	1995	Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia.	Asparagine	10-22	asparaginase	Homo sapiens	68-80
7844595-1	1995	PURPOSE: As part of a study on the pharmacokinetics associated with the administration of asparaginase (ASNase) from Erwinia to the CNS, we determined the levels of asparagine in the CSF of children with acute lymphoblastic leukemia (ALL).	Asparagine	165-175	asparaginase	Homo sapiens	90-102
7844595-1	1995	PURPOSE: As part of a study on the pharmacokinetics associated with the administration of asparaginase (ASNase) from Erwinia to the CNS, we determined the levels of asparagine in the CSF of children with acute lymphoblastic leukemia (ALL).	Asparagine	165-175	asparaginase	Homo sapiens	104-110
7844595-1	1995	PURPOSE: As part of a study on the pharmacokinetics associated with the administration of asparaginase (ASNase) from Erwinia to the CNS, we determined the levels of asparagine in the CSF of children with acute lymphoblastic leukemia (ALL).	Asparagine	165-175	colony stimulating factor 2	Homo sapiens	183-186
7844595-4	1995	RESULTS: All patients had detectable levels of L-asparagine in the CSF at the time of diagnosis.	Asparagine	47-59	colony stimulating factor 2	Homo sapiens	67-70
7844595-5	1995	The levels of L-asparagine in CSF were undetectable in 15 of 20 (75%) and in seven of 19 (36.8%) children 3 and 5 days, respectively, after administration of standard-dose ASNase.	Asparagine	14-26	colony stimulating factor 2	Homo sapiens	30-33
7844595-6	1995	After administration of high-dose ASNase, the levels of L-asparagine in the CSF were undetectable in five (62.5%) and two (25%) of eight children after 3 and 5 days, respectively.	Asparagine	56-68	asparaginase	Homo sapiens	34-40
7844595-6	1995	After administration of high-dose ASNase, the levels of L-asparagine in the CSF were undetectable in five (62.5%) and two (25%) of eight children after 3 and 5 days, respectively.	Asparagine	56-68	colony stimulating factor 2	Homo sapiens	76-79
7844595-7	1995	CONCLUSION: In this study 60% to 70% and 25% to 35% of children had complete depletion of L-asparagine from the CSF after 3 and 5 days, respectively, after administration of both schedules of ASNase from Erwinia.	Asparagine	90-102	colony stimulating factor 2	Homo sapiens	112-115
7844595-7	1995	CONCLUSION: In this study 60% to 70% and 25% to 35% of children had complete depletion of L-asparagine from the CSF after 3 and 5 days, respectively, after administration of both schedules of ASNase from Erwinia.	Asparagine	90-102	asparaginase	Homo sapiens	192-198
7840781-1	1995	An antibody was raised against a synthetic peptide (Ser-Glu-Asn-Tyr-Lys-Asp-Asn) corresponding to residues 290-296 of the cytochrome P450 enzyme, CYP1A2, of both rat and mouse.	Asparagine	60-63	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	146-152
7822295-4	1995	In this study the role of the His440 residue was explored through site-directed mutagenesis which resulted in the production of ETA proteins containing Ala, Asn, and Phe substitutions at the 440 position.	Asparagine	157-160	endothelin receptor type A	Homo sapiens	128-131
7843422-1	1995	Information on the structures of the oligosaccharides linked to Asn residues 159 and 391 of the human complement protease C1s was obtained using mass spectrometric and monosaccharide analyses.	Asparagine	64-67	complement C1s	Homo sapiens	122-125
7862092-8	1995	Another is a novel gene, ASM4, whose gene product is rich in asparagine and glutamine residues.	Asparagine	61-71	FG-nucleoporin ASM4	Saccharomyces cerevisiae S288C	25-29
7840622-1	1995	The gelatin-binding region of fibronectin contains three Asn-linked carbohydrate moieties, one on the second type II module and two on the eighth type I "finger" module.	Asparagine	57-60	fibronectin 1	Homo sapiens	30-41
7840781-8	1995	Antibodies raised against a truncated peptide (Tyr-Lys-Asp-Asn), representing the C-terminal half of the peptide, also bound to glucose-6-phosphate dehydrogenase, but failed to bind to CYP1A2; thus although the C-terminal region of the peptide 290-296 is strongly immunogenic, it appears that it is not this population of antibodies that binds to CYP1A2.	Asparagine	59-62	glucose-6-phosphate dehydrogenase	Rattus norvegicus	128-161
7762756-5	1995	Its pI and molecular weight were the same as those of a physiological variant of antithrombin III (beta fraction), which is known to lack the asparagine-N-linked oligosaccharide chain at asparagine-135.	Asparagine	142-152	serpin family C member 1	Homo sapiens	81-97
7833265-2	1995	The causative mutation has already been shown to be an A to T transversion in codon 280 of the FVIII gene which replaces Asn 280 (AAC) by Ile (ATC) and which creates a new Bam HI restriction site in exon 7.	Asparagine	121-124	coagulation factor VIII	Homo sapiens	95-100
7833265-2	1995	The causative mutation has already been shown to be an A to T transversion in codon 280 of the FVIII gene which replaces Asn 280 (AAC) by Ile (ATC) and which creates a new Bam HI restriction site in exon 7.	Asparagine	121-124	glycine-N-acyltransferase	Homo sapiens	130-133
10188794-1	1995	Aspartate 103 (D103) in the third transmembrane domain of the Hm2 receptor was mutated to glutamate (D103E), asparagine (D103N), or alanine (D103A).	Asparagine	109-119	cholinergic receptor muscarinic 2	Homo sapiens	62-65
8808011-3	1995	Long-term treatment with human recombinant growth hormone normalized plasma alanine, glutamine, and glutamic acid levels, increased the OH-Pro concentration, and did not alter the amino acid ratios of Gly/Val, Phe/Tyr, Ser/Gly, and Asn/Asp, but the Gln/Glu ratio approached the normal value.	Asparagine	232-235	growth hormone 1	Homo sapiens	43-57
7706936-1	1995	It has previously been estimated that due to genetic "founder effects," 97% of lipoprotein lipase (LPL) gene alleles conferring type I hyperlipoproteinemia (HLP) in French Canadians encode one of the following mutant LPL forms: Gly188--&gt;Glu, Pro207--&gt;Leu, or Asp250--&gt;Asn.	Asparagine	277-280	lipoprotein lipase	Homo sapiens	79-97
7706936-1	1995	It has previously been estimated that due to genetic "founder effects," 97% of lipoprotein lipase (LPL) gene alleles conferring type I hyperlipoproteinemia (HLP) in French Canadians encode one of the following mutant LPL forms: Gly188--&gt;Glu, Pro207--&gt;Leu, or Asp250--&gt;Asn.	Asparagine	277-280	lipoprotein lipase	Homo sapiens	99-102
7706936-1	1995	It has previously been estimated that due to genetic "founder effects," 97% of lipoprotein lipase (LPL) gene alleles conferring type I hyperlipoproteinemia (HLP) in French Canadians encode one of the following mutant LPL forms: Gly188--&gt;Glu, Pro207--&gt;Leu, or Asp250--&gt;Asn.	Asparagine	277-280	lipoprotein lipase	Homo sapiens	217-220
7821814-1	1994	Sequence information for aspartyl beta-hydroxylase (AspH), which specifically hydroxylates one Asp or Asn residue in certain epidermal growth factor (EGF)-like domains of a number of proteins, is so far only described for bovine species.	Asparagine	102-105	aspartate beta-hydroxylase	Bos taurus	25-50
7999759-1	1994	The role of asparagine-713 in iron atom incorporation and catalysis in soybean lipoxygenase 3 was investigated using site-directed mutagenesis.	Asparagine	12-22	seed linoleate 9S-lipoxygenase-3	Glycine max	79-93
7999759-5	1994	Two recent structure reports provided conflicting views about the participation of the side chain of asparagine-694 in the coordination of the iron atom required for catalysis by lipoxygenase 1.	Asparagine	101-111	seed linoleate 13S-lipoxygenase-1	Glycine max	179-193
7999759-6	1994	Oligonucleotide-directed mutagenesis was employed to modify residue 713 in lipoxygenase 3 which corresponds to asparagine-694 in the sequence of lipoxygenase 1.	Asparagine	111-121	linoleate 9S-lipoxygenase-4	Glycine max	75-87
7999759-6	1994	Oligonucleotide-directed mutagenesis was employed to modify residue 713 in lipoxygenase 3 which corresponds to asparagine-694 in the sequence of lipoxygenase 1.	Asparagine	111-121	seed linoleate 13S-lipoxygenase-1	Glycine max	145-159
7821814-1	1994	Sequence information for aspartyl beta-hydroxylase (AspH), which specifically hydroxylates one Asp or Asn residue in certain epidermal growth factor (EGF)-like domains of a number of proteins, is so far only described for bovine species.	Asparagine	102-105	aspartate beta-hydroxylase	Bos taurus	52-56
7854004-4	1994	We also replaced the adjacent asparagine residues in two additional mutants, LCAT (Ser19--&gt;Ala, Asn20--&gt;Thr) and LCAT (Ser383--&gt;Ala, Asn384--&gt;Thr), in order to ascertain the effect of the serines on N-glycosylation.	Asparagine	30-40	lecithin-cholesterol acyltransferase	Homo sapiens	77-81
7527558-5	1994	Mutants of c-Src in which the amino-terminal basic residues were replaced by neutral asparagine residues exhibited binding isotherms approaching that of wild-type binding to neutral bilayers (apparent Kd of 2 x 10(-3) M).	Asparagine	85-95	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
7881424-2	1994	All the analyzed patients are found to carry a nucleotide substitution of A or T for G654 in their gelsolin gene, which at the protein level results in the conversion of the 187 amino acid residue, aspartic acid, to asparagine or tyrosine, respectively.	Asparagine	216-226	gelsolin	Homo sapiens	99-107
7756988-8	1994	The structure of the d(CpA) complex permits a detailed analysis of the downstream binding site, which includes His 119 and Asn 71.	Asparagine	123-126	carboxypeptidase A1	Homo sapiens	23-26
7980452-1	1994	Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain.	Asparagine	130-133	interferon gamma	Homo sapiens	6-22
7846154-8	1994	Moreover, this sucrose repression of ASN1 expression can be partially rescued by supplementation with exogenous amino acids such as asparagine, glutamine, and glutamate.	Asparagine	132-142	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	37-41
7846154-10	1994	This is consistent with the fact that asparagine, synthesized by the ASN1 gene product, is a favored compound for nitrogen storage and nitrogen transport in dark-grown plants.	Asparagine	38-48	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	69-73
7846154-11	1994	We have put forth a working model suggesting that when nitrogen to carbon ratios are high, the gene product of ASN1 functions to re-direct the flow of nitrogen into asparagine, which acts as a shunt for storage and/or long-distance transport of nitrogen.	Asparagine	165-175	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	111-115
7999071-0	1994	A naturally occurring mutation at the second base of codon asparagine 43 in the proposed N-linked glycosylation site of human lipoprotein lipase: in vivo evidence that asparagine 43 is essential for catalysis and secretion.	Asparagine	59-69	lipoprotein lipase	Homo sapiens	126-144
7999071-0	1994	A naturally occurring mutation at the second base of codon asparagine 43 in the proposed N-linked glycosylation site of human lipoprotein lipase: in vivo evidence that asparagine 43 is essential for catalysis and secretion.	Asparagine	168-178	lipoprotein lipase	Homo sapiens	126-144
7961659-8	1994	The results 1) confirm the predictions of the model that Asn-204, Glu-256, and Glu-290 are important residues involved in catalysis and hydrogen bonding glucose hydroxyl groups, 2) provide evidence for a role of Lys-56 in hexose binding, and 3) are consistent with the cooperative behavior of glucokinase being mediated by interactions of other regions of the protein with the highly conserved active site glucose binding residues.	Asparagine	57-60	glucokinase	Homo sapiens	293-304
7757424-0	1994	Synthesis and structural studies of asparagine-modified 2-deoxy-alpha-N-glycopeptides associated with the renin-angiotensin system.	Asparagine	36-46	renin	Homo sapiens	106-111
7538848-1	1994	Alanine-scanning mutagenesis on human growth hormone (hGH) identified 5 primary determinants (Arg 8, Asn 12, Arg 16, Asp 112, and Asp 116) for binding to a monoclonal antibody (MAb 3) (Jin L, Fendly BM, Wells JA, 1992, J Mol Biol 226:851-865).	Asparagine	101-104	growth hormone 1	Homo sapiens	38-52
7961941-2	1994	We have mutated the aspartate residue in the putative second transmembrane spanning domain of the alpha 2A-adrenergic receptor (alpha 2AAR) to the non-negatively charged asparagine (D79N) and glutamine (D79Q) and the negatively charged glutamate (D79E) residue in an effort to better characterize the role of this residue, highly conserved among G-protein-coupled receptors, in Na+ regulation of ligand binding and in receptor G-protein coupling.	Asparagine	170-180	adrenergic receptor, alpha 2a	Mus musculus	98-126
7980452-1	1994	Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain.	Asparagine	130-133	interferon gamma	Homo sapiens	24-33
7980452-1	1994	Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain.	Asparagine	141-144	interferon gamma	Homo sapiens	6-22
7980452-1	1994	Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain.	Asparagine	141-144	interferon gamma	Homo sapiens	24-33
7980452-7	1994	The formation of biologically active dimers was more efficient for IFN-gamma polypeptides that had the intact glycosylation site at Asn-25 as compared with the other two mutant forms of IFN-gamma.	Asparagine	132-135	interferon gamma	Homo sapiens	67-76
7954361-1	1994	We have previously shown that asparagine alone induces a 10-15-fold increase in ornithine decarboxylase (ODC) mRNA level in DF-40 mouse neuroblastoma cells.	Asparagine	30-40	ornithine decarboxylase, structural 1	Mus musculus	80-103
7713746-0	1994	Two new alpha chain variants found during glycated hemoglobin screening: Hb Tatras [alpha 7(A5)Lys-->Asn] and HB Lisbon [alpha 23(B4)Glu-->Asp].	Asparagine	101-104	immunoglobulin kappa variable 2D-26	Homo sapiens	73-94
7535613-11	1994	The PSA glycosylation site, Asn 61, is fully accessible to the solvent and is enclosed in a positive region of the isopotential map.	Asparagine	28-31	kallikrein related peptidase 3	Homo sapiens	4-7
7954361-0	1994	Asparagine markedly induces the expression of ornithine decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts.	Asparagine	0-10	ornithine decarboxylase 1	Homo sapiens	46-69
7703854-1	1994	To probe the role of the Asp-99 ... His-48 pair in phospholipase A2 (PLA2) catalysis, the X-ray structure and kinetic characterization of the mutant Asp-99--&gt;Asn-99 (D99N) of bovine pancreatic PLA2 was undertaken.	Asparagine	161-164	LOC104974671	Bos taurus	51-67
7703854-6	1994	Although the geometry of the catalytic triad in the PLA2 mutant remains the same as in the WT, we were surprised that the conserved structural water, linking the catalytic site with the ammonium group of Ala-1 of the interfacial site, was ejected by the proximity of the NH2 group of Asn-99.	Asparagine	284-287	LOC104974671	Bos taurus	52-56
7929395-7	1994	Five partially hydroxylated Asn residues have been identified by protein sequence analysis of fibrillin-1 fragments.	Asparagine	28-31	fibrillin 1	Homo sapiens	94-105
7954361-1	1994	We have previously shown that asparagine alone induces a 10-15-fold increase in ornithine decarboxylase (ODC) mRNA level in DF-40 mouse neuroblastoma cells.	Asparagine	30-40	ornithine decarboxylase, structural 1	Mus musculus	105-108
7954361-6	1994	In the present study we showed that asparagine induced ODC gene expression in v-Ha-ras-transformed 3T3 (ras-3T3) cells but not in 3T3 cells.	Asparagine	36-46	ornithine decarboxylase, structural 1	Mus musculus	55-58
7954361-9	1994	The effect of asparagine on the induction of ODC mRNA could account for the significant increases in the ODC activity in ras-3T3 cells.	Asparagine	14-24	ornithine decarboxylase 1	Homo sapiens	45-48
7954361-9	1994	The effect of asparagine on the induction of ODC mRNA could account for the significant increases in the ODC activity in ras-3T3 cells.	Asparagine	14-24	ornithine decarboxylase 1	Homo sapiens	105-108
7954361-10	1994	We also examined the effect of asparagine on ODC gene expression in human KD cells and their transformed counterparts.	Asparagine	31-41	ornithine decarboxylase 1	Homo sapiens	45-48
7954361-11	1994	Our findings strongly suggest that the induction of ODC mRNA by asparagine may represent a component of an altered growth regulatory program associated most prominently with cell transformation.	Asparagine	64-74	ornithine decarboxylase 1	Homo sapiens	52-55
7957895-0	1994	Specificities of the two center N inhibitors of mitochondial bc1 complex, antimycin and funiculosin: strong involvement of cytochrome b-asparagine-208 in funiculosin binding.	Asparagine	136-146	mitochondrially encoded cytochrome b	Homo sapiens	123-135
7971270-1	1994	Two residues are invariant in all bZip basic regions: asparagine -18 and arginine -10 (we define the first leucine of the leucine zipper of GCN4 as +1).	Asparagine	54-64	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	140-144
7947964-2	1994	Pronase digestion of thiostatin yielded a major glycopeptide fraction with asparagine the most abundant amino acid present.	Asparagine	75-85	kininogen 2	Rattus norvegicus	21-31
7929152-0	1994	The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.	Asparagine	46-49	fibronectin 1	Homo sapiens	59-70
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	42-45	haptoglobin-related protein	Homo sapiens	104-107
7923176-11	1994	p53 allelic amino acid variation with sequences coding for aspartic acid or asparagine was present in codon 61 in the variable region of exon 4 in both HCCs and nonneoplastic tissues of ground squirrels.	Asparagine	76-86	tumor protein p53	Homo sapiens	0-3
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	42-45	THO complex 1	Homo sapiens	187-192
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Asparagine	53-56	interleukin 1 beta	Homo sapiens	101-119
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	42-45	heparanase 2 (inactive)	Homo sapiens	197-202
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	53-56	haptoglobin-related protein	Homo sapiens	104-107
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	53-56	THO complex 1	Homo sapiens	187-192
7929130-1	1994	The non-enzymatic deamidation at residues Asn-12 and Asn-38 of Escherichia coli phosphocarrier protein, HPr, and the repair of the resulting L-isoaspartyl (or beta-aspartyl) derivatives, HPr-1 and HPr-2, by recombinant human S-adenosylmethionine-dependent L-isoaspartate-(D-aspartate) O-methyltransferase (EC 2.1.1.77) were investigated.	Asparagine	53-56	heparanase 2 (inactive)	Homo sapiens	197-202
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Asparagine	53-56	interleukin 1 beta	Homo sapiens	121-130
8084588-5	1994	We now report that, in vitro, the high affinity binding of Grb2 to Shc proteins requires phosphorylation of Shc at Tyr317, which lies within the high affinity binding motif for the Grb2 SH2 domain, pYVNV, where Asn at the +2 position is crucial for complex formation.	Asparagine	211-214	growth factor receptor bound protein 2	Homo sapiens	59-63
7961105-4	1994	In 2 (10%) of the 20 cases examined, an identical sequence abnormality was detected in E-cadherin exon 7, i.e. a point mutation of codon 315 (AAT to AGT) which resulted in a single amino acid substitution (asparagine to serine).	Asparagine	206-216	cadherin 1	Homo sapiens	87-97
8084588-5	1994	We now report that, in vitro, the high affinity binding of Grb2 to Shc proteins requires phosphorylation of Shc at Tyr317, which lies within the high affinity binding motif for the Grb2 SH2 domain, pYVNV, where Asn at the +2 position is crucial for complex formation.	Asparagine	211-214	SHC adaptor protein 1	Homo sapiens	67-70
8084588-5	1994	We now report that, in vitro, the high affinity binding of Grb2 to Shc proteins requires phosphorylation of Shc at Tyr317, which lies within the high affinity binding motif for the Grb2 SH2 domain, pYVNV, where Asn at the +2 position is crucial for complex formation.	Asparagine	211-214	SHC adaptor protein 1	Homo sapiens	108-111
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Asparagine	90-93	T cell receptor beta locus	Homo sapiens	102-110
8091650-7	1994	When the P6 aspartic acid was changed to asparagine, lysine, or serine, NS3-mediated cleavage occurred.	Asparagine	41-51	KRAS proto-oncogene, GTPase	Homo sapiens	72-75
8089117-2	1994	An apparently unique enzyme, designated protein NH2-terminal asparagine deamidase (PNAD), that specifically converts NH2-terminal asparagine residues of peptide and protein substrates to aspartic acid, has been isolated to homogeneity from porcine liver by an eight-step procedure.	Asparagine	61-71	N-terminal asparagine amidase	Homo sapiens	83-87
8089117-4	1994	PNAD does not act on internal asparagine residues and requires a free N alpha-amino group.	Asparagine	30-40	N-terminal asparagine amidase	Homo sapiens	0-4
8089117-10	1994	Conversion of the resulting NH2-terminal asparagine to aspartic acid by PNAD would render the protein susceptible to arginylation, polyubiquitinylation and degradation as specified by the N-end rule.	Asparagine	41-51	N-terminal asparagine amidase	Homo sapiens	72-76
7945410-9	1994	Asparagine-linked complex chain N-glycosylation of the purified MCR was also observed.	Asparagine	0-10	nuclear receptor subfamily 3 group C member 2	Bos taurus	64-67
8075071-1	1994	Substitution Asp138--&gt;Asn changes the substrate specificity of elongation factor (EF) Tu from GTP to XTP [Hwang &amp; Miller (1987) J. Biol.	Asparagine	25-28	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	66-91
8089099-6	1994	We now show that asparagine at position 110 of transmembrane helix 3 directly interacts with the ring N-H of the TRH pyroglutamyl moiety.	Asparagine	17-27	thyrotropin releasing hormone	Homo sapiens	113-116
8078584-8	1994	We found that a single amino-acid change within the putative transmembrane domain M2, aspartate (D) in IRK1 to the corresponding asparagine (N) in ROMK1, controls the gating phenotype.	Asparagine	129-139	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	103-107
8078584-8	1994	We found that a single amino-acid change within the putative transmembrane domain M2, aspartate (D) in IRK1 to the corresponding asparagine (N) in ROMK1, controls the gating phenotype.	Asparagine	129-139	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	147-152
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Asparagine	90-93	T cell receptor alpha constant	Homo sapiens	245-254
8068684-1	1994	The ubiquitously-expressed human Na+H+ exchanger (NHE-1) contains three consensus sites (Asn-X-Ser/Thr) for N-linked glycosylation at asparagines 75, 370, and 410.	Asparagine	134-145	solute carrier family 9 member A1	Homo sapiens	50-55
7815466-3	1994	We report a mutation within exon eight of the MYH7 gene at a very conserved amino acid at position 232, which results in the conversion of an asparagine to serine.	Asparagine	142-152	myosin heavy chain 7	Homo sapiens	46-50
7815466-5	1994	According to recent results on the three-dimensional structure of the myosin head or subfragment-1 (S1), Asn-232 is located in an alpha-helix which forms part of the nucleotide binding pocket.	Asparagine	105-108	myosin heavy chain 14	Homo sapiens	70-76
7634100-5	1994	Upon titration with DNA, resonance shifts in the backbone and Asn and Gln side-chain amides indicate that helix 3 acts as the recognition helix of the heat shock transcription factor.	Asparagine	62-65	Heat shock factor	Drosophila melanogaster	151-182
7923583-0	1994	The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity.	Asparagine	56-66	O-6-methylguanine-DNA methyltransferase	Homo sapiens	75-113
7806965-0	1994	Lipoprotein lipase and hepatic lipase: the role of asparagine-linked glycosylation in the expression of a functional enzyme.	Asparagine	51-61	lipoprotein lipase	Homo sapiens	0-18
7806965-1	1994	Lipoprotein lipase (LPL) and hepatic lipase (HL) share two conserved asparagine-linked glycosylation sites, located at the amino- and carboxy-terminal domains of the protein.	Asparagine	69-79	lipoprotein lipase	Homo sapiens	0-18
7806965-1	1994	Lipoprotein lipase (LPL) and hepatic lipase (HL) share two conserved asparagine-linked glycosylation sites, located at the amino- and carboxy-terminal domains of the protein.	Asparagine	69-79	lipoprotein lipase	Homo sapiens	20-23
7806965-1	1994	Lipoprotein lipase (LPL) and hepatic lipase (HL) share two conserved asparagine-linked glycosylation sites, located at the amino- and carboxy-terminal domains of the protein.	Asparagine	69-79	lipase C, hepatic type	Homo sapiens	29-43
7806965-1	1994	Lipoprotein lipase (LPL) and hepatic lipase (HL) share two conserved asparagine-linked glycosylation sites, located at the amino- and carboxy-terminal domains of the protein.	Asparagine	69-79	lipase C, hepatic type	Homo sapiens	45-47
7806965-8	1994	3) Glycosylation at the conserved Asn sites in the N-terminal domain of LPL and HL is required for the synthesis of a fully active and secreted lipase.	Asparagine	34-37	lipoprotein lipase	Homo sapiens	72-75
7806965-8	1994	3) Glycosylation at the conserved Asn sites in the N-terminal domain of LPL and HL is required for the synthesis of a fully active and secreted lipase.	Asparagine	34-37	lipase C, hepatic type	Homo sapiens	80-82
8057461-9	1994	We also expressed and purified an nsP2 variant which had a single amino acid substitution in the nucleotide-binding motif (Lys-192--&gt;Asn).	Asparagine	136-139	reticulon 2	Homo sapiens	34-38
8039140-9	1994	A p53 gene mutation was also found in 1 of 10 carcinomas examined; a G--&gt;T transversion was detected at the third letter of codon 130, with a substitution of asparagine for lysine.	Asparagine	161-171	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	2-5
8052627-3	1994	A mutation of virG, virGN54D (which codes for a Asn-54--&gt;Asp amino acid change in the product), causes constitutive expression of other vir genes independent of virA.	Asparagine	48-51	two-component response regulator VirG	Agrobacterium tumefaciens	14-18
7914890-5	1994	An earlier study had shown that a mutant arylsulfatase A containing only the second N-glycosylation site at Asn-184 folds correctly and is phosphorylated (Gieselmann, V., Schmidt, B., and von Figura, K. (1992) J. Biol.	Asparagine	108-111	arylsulfatase A	Homo sapiens	41-56
7914890-8	1994	The lack of phosphorylation at Asn-184 in wild type arylsulfatase A therefore indicates that in vivo the presence of oligosaccharides can interfere with phosphorylation of other sites or that phosphorylation occurs in an ordered manner whereby phosphorylation of one site can affect the phosphorylation of another site.	Asparagine	31-34	arylsulfatase A	Homo sapiens	52-67
7800847-3	1994	However, sequencing of chicken PP using modem automated gas-phase sequencing technology has revealed that the original primary structure is incorrect in that residue 22 is Asn and that residue 23 is Asp.	Asparagine	172-175	pancreatic hormone	Gallus gallus	31-33
8074227-8	1994	In cultured IEC-6 cells, ODC activity was significantly increased after exposure to gastrin, 5% dialyzed fetal bovine serum (FBS), EGF, and asparagine.	Asparagine	140-150	ornithine decarboxylase 1	Rattus norvegicus	25-28
8037771-1	1994	Evidence for the involvement of four spatially clustered residues, Asp260(94), His261(95), Glu408(242) and Met409(243), in catalytic and spectral properties of human myeloperoxidase was provided by the analysis of site-directed mutants wherein these amino acids have been substituted by asparagine, alanine, glutamine and glutamine respectively.	Asparagine	287-297	myeloperoxidase	Homo sapiens	166-181
8050502-4	1994	Replacement of asparagine residues at all N-glycosylation sites of Epo with glutamine by site-directed mutagenesis resulted in roughly equal secretion from apical and basolateral domains.	Asparagine	15-25	erythropoietin	Canis lupus familiaris	67-70
7952083-0	1994	Determination of L-asparagine in biological samples in the presence of L-asparaginase.	Asparagine	17-29	asparaginase and isoaspartyl peptidase 1	Homo sapiens	71-85
8055928-6	1994	In rodents, the P3 Asp residue of the human thrombin receptor is replaced by Asn and in protein C, the P3" residue is Asn.	Asparagine	77-80	coagulation factor II, thrombin	Homo sapiens	44-52
8055928-6	1994	In rodents, the P3 Asp residue of the human thrombin receptor is replaced by Asn and in protein C, the P3" residue is Asn.	Asparagine	118-121	coagulation factor II, thrombin	Homo sapiens	44-52
7912957-0	1994	An invariant asparagine in the POU-specific homeodomain regulates the specificity of the Oct-2 POU motif.	Asparagine	13-23	POU class 2 homeobox 2	Homo sapiens	89-94
7952083-3	1994	A method was therefore developed for the determination of L-asparagine in patients receiving L-asparaginase.	Asparagine	58-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	93-107
7952083-1	1994	The antileukaemic efficacy of L-asparaginase is related to the ability of the enzyme to induce the complete disappearance from plasma of L-asparagine, an amino acid essential to lymphoblastic leukaemia cells.	Asparagine	137-149	asparaginase and isoaspartyl peptidase 1	Homo sapiens	30-44
7515913-6	1994	By mutating together or individually, the three asparagines present on SCRs 5 to 8, asparagines (Asn) 370 and 295, but not Asn 492, were shown to be involved critically in the binding of CD23.	Asparagine	48-59	Fc epsilon receptor II	Homo sapiens	187-191
7515913-6	1994	By mutating together or individually, the three asparagines present on SCRs 5 to 8, asparagines (Asn) 370 and 295, but not Asn 492, were shown to be involved critically in the binding of CD23.	Asparagine	84-95	Fc epsilon receptor II	Homo sapiens	187-191
7515913-6	1994	By mutating together or individually, the three asparagines present on SCRs 5 to 8, asparagines (Asn) 370 and 295, but not Asn 492, were shown to be involved critically in the binding of CD23.	Asparagine	97-100	Fc epsilon receptor II	Homo sapiens	187-191
7515913-6	1994	By mutating together or individually, the three asparagines present on SCRs 5 to 8, asparagines (Asn) 370 and 295, but not Asn 492, were shown to be involved critically in the binding of CD23.	Asparagine	123-126	Fc epsilon receptor II	Homo sapiens	187-191
8204630-1	1994	The specific deamidation of asparagine-71 of triosephosphate isomerase increases upon substrate binding and catalysis.	Asparagine	28-38	triosephosphate isomerase 1	Homo sapiens	45-70
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Asparagine	188-191	citrate synthase	Sus scrofa	70-86
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Asparagine	200-203	citrate synthase	Sus scrofa	70-86
8013629-6	1994	A point mutation of Asn at position 72 for ARA-2, or 71 for ARA-4, to Ile decreased GTP-binding and a point mutation of Gln at position 126 for ARA-2, or 125 for ARA-4, to Leu suppressed GTP-hydrolysis activity.	Asparagine	20-23	Ras-related small GTP-binding family protein	Arabidopsis thaliana	43-48
8013629-6	1994	A point mutation of Asn at position 72 for ARA-2, or 71 for ARA-4, to Ile decreased GTP-binding and a point mutation of Gln at position 126 for ARA-2, or 125 for ARA-4, to Leu suppressed GTP-hydrolysis activity.	Asparagine	20-23	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	60-65
7937515-1	1994	The influence of intramolecular catalysis and self-association on the kinetics of deamidation at the A-21 Asn residue of human insulin was explored at low pH and 35 degrees C. Observed rate constants of overall insulin degradation were determined as a function of pH over a pH range of 2.0-5.0 and as a function of total insulin concentration between pH 2.0-4.0.	Asparagine	106-109	insulin	Homo sapiens	127-134
8207403-3	1994	Each of the four sites was removed by in vitro mutagenesis of gp160 sequence in the non-infectious viral clone pEVd1443, so that amino acids 616, 621, 642 and 679 were each changed from asparagine to serine.	Asparagine	186-196	glutamyl aminopeptidase	Homo sapiens	62-67
8207403-7	1994	The results of this study indicate that N-linked glycosylation of Asn-642 in the glycoprotein produced by the pEVd1443 expression system is necessary for the correct intracellular processing of gp160 to yield surface-expressed, fusogenic gp41.	Asparagine	66-69	glutamyl aminopeptidase	Homo sapiens	194-199
8022404-11	1994	They also imply that the AT2 receptor contains at least three asparagine-linked sites of glycosylation.	Asparagine	62-72	angiotensin II receptor type 2	Homo sapiens	25-28
7514386-0	1994	Structural study on the glycosyl-phosphatidylinositol anchor and the asparagine-linked sugar chain of a soluble form of CD59 in human urine.	Asparagine	69-79	CD59 molecule (CD59 blood group)	Homo sapiens	120-124
8185569-1	1994	Residue 113 of the thyrotropin receptor (TSHR) is a possible asparagine-linked glycosylation site in the human TSHR, but not in rat or dog TSHR.	Asparagine	61-71	thyroid stimulating hormone receptor	Homo sapiens	19-39
8185569-1	1994	Residue 113 of the thyrotropin receptor (TSHR) is a possible asparagine-linked glycosylation site in the human TSHR, but not in rat or dog TSHR.	Asparagine	61-71	thyroid stimulating hormone receptor	Homo sapiens	41-45
8185569-1	1994	Residue 113 of the thyrotropin receptor (TSHR) is a possible asparagine-linked glycosylation site in the human TSHR, but not in rat or dog TSHR.	Asparagine	61-71	thyroid stimulating hormone receptor	Homo sapiens	111-115
8185569-1	1994	Residue 113 of the thyrotropin receptor (TSHR) is a possible asparagine-linked glycosylation site in the human TSHR, but not in rat or dog TSHR.	Asparagine	61-71	thyroid stimulating hormone receptor	Canis lupus familiaris	111-115
8182076-7	1994	Replacement of a non-canonical asparagine with leucine in the yAP-1 leucine zipper leads to production of a defective protein.	Asparagine	31-41	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	62-67
7514386-4	1994	The structures of the GPI anchor and the asparagine-linked sugar chain of a soluble form of CD59 in urine, U-CD59, were determined.	Asparagine	41-51	CD59 molecule (CD59 blood group)	Homo sapiens	92-96
7514386-4	1994	The structures of the GPI anchor and the asparagine-linked sugar chain of a soluble form of CD59 in urine, U-CD59, were determined.	Asparagine	41-51	CD59 molecule (CD59 blood group)	Homo sapiens	109-113
7514386-10	1994	The structures of the asparagine-linked sugar chains of U-CD59 were biantennary complex type, only 4.2% of which are monosialylated.	Asparagine	22-32	CD59 molecule (CD59 blood group)	Homo sapiens	58-62
8203529-2	1994	The structurally related amino acid, L-asparagine (Asn), stimulates the proliferative enzyme ornithine decarboxylase in colonocytes, an effect that is blocked by the Na+-H+ exchange inhibitor amiloride.	Asparagine	37-49	ornithine decarboxylase 1	Homo sapiens	93-116
8180397-2	1994	Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine.	Asparagine	127-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
8175741-8	1994	The nat2-1 mutants were deficient in the ability to acetylate Met-Asn-Asn- and Met-Glu-Arg-peptides but were able to N alpha-acetylate Ser-Glu-Phe- and Ser-Tyr-Ser- peptides in vitro.	Asparagine	66-69	Nat2p	Saccharomyces cerevisiae S288C	4-8
8175741-8	1994	The nat2-1 mutants were deficient in the ability to acetylate Met-Asn-Asn- and Met-Glu-Arg-peptides but were able to N alpha-acetylate Ser-Glu-Phe- and Ser-Tyr-Ser- peptides in vitro.	Asparagine	70-73	Nat2p	Saccharomyces cerevisiae S288C	4-8
8183949-9	1994	By mutating single amino acids of the beta 1 subunit to the beta 2/beta 3 equivalent, only the beta 1 mutation of Ser-290--&gt;Asn conferred potentiation by loreclezole.	Asparagine	127-130	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	95-101
8185325-7	1994	We report the characterization of Asn-linked glycosylation sites in ME20-M and ME20-S to determine the involvement of oligosaccharides in the proteolytic processing of pro-ME20 antigen.	Asparagine	34-37	premelanosome protein	Homo sapiens	68-74
8185325-7	1994	We report the characterization of Asn-linked glycosylation sites in ME20-M and ME20-S to determine the involvement of oligosaccharides in the proteolytic processing of pro-ME20 antigen.	Asparagine	34-37	premelanosome protein	Homo sapiens	68-72
8175750-10	1994	Because in the case of PGHS-1 a smaller asparagine substitution is sufficient to eliminate cyclooxygenase activity, we conclude that the active site of PGHS-2 is slightly larger than that of PGHS-1.	Asparagine	40-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	152-158
8175750-10	1994	Because in the case of PGHS-1 a smaller asparagine substitution is sufficient to eliminate cyclooxygenase activity, we conclude that the active site of PGHS-2 is slightly larger than that of PGHS-1.	Asparagine	40-50	prostaglandin-endoperoxide synthase 1	Homo sapiens	191-197
8183949-10	1994	Similarly, mutation of the homologous residue in the beta 2 and beta 3 subunits to the beta 1 equivalent (Asn--&gt;Ser) resulted in loss of sensitivity to loreclezole.	Asparagine	106-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	53-70
8183949-10	1994	Similarly, mutation of the homologous residue in the beta 2 and beta 3 subunits to the beta 1 equivalent (Asn--&gt;Ser) resulted in loss of sensitivity to loreclezole.	Asparagine	106-109	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	87-93
8183949-12	1994	Thus, a single amino acid, beta 2 Asn-289 (beta 3 Asn-290), located at the carboxyl-terminal end of the putative channel-lining domain TM2, confers sensitivity to the modulatory effects of loreclezole.	Asparagine	34-37	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-33
8183949-12	1994	Thus, a single amino acid, beta 2 Asn-289 (beta 3 Asn-290), located at the carboxyl-terminal end of the putative channel-lining domain TM2, confers sensitivity to the modulatory effects of loreclezole.	Asparagine	34-37	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	43-49
8183949-12	1994	Thus, a single amino acid, beta 2 Asn-289 (beta 3 Asn-290), located at the carboxyl-terminal end of the putative channel-lining domain TM2, confers sensitivity to the modulatory effects of loreclezole.	Asparagine	50-53	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-33
8183949-12	1994	Thus, a single amino acid, beta 2 Asn-289 (beta 3 Asn-290), located at the carboxyl-terminal end of the putative channel-lining domain TM2, confers sensitivity to the modulatory effects of loreclezole.	Asparagine	50-53	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	43-49
8203529-2	1994	The structurally related amino acid, L-asparagine (Asn), stimulates the proliferative enzyme ornithine decarboxylase in colonocytes, an effect that is blocked by the Na+-H+ exchange inhibitor amiloride.	Asparagine	51-54	ornithine decarboxylase 1	Homo sapiens	93-116
8203529-6	1994	Asn and Gln had no measurable effect on resting pHi, but pretreatment with Asn or Gln induced a consistent twofold increase in pHi recovery from an acid challenge that was not seen with L-proline, D-glutamine, or L-phenylalanine.	Asparagine	75-78	glucose-6-phosphate isomerase	Homo sapiens	127-130
8171029-0	1994	Structure and function in rhodopsin: the role of asparagine-linked glycosylation.	Asparagine	49-59	rhodopsin	Bos taurus	26-35
8151754-5	1994	This mutant was found to contain a mutation in the glycoprotein D (gD) coding sequence that results in the substitution of the serine at position 140 in the mature protein to asparagine.	Asparagine	175-185	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	51-65
8185828-5	1994	cDNA polymerase chain reaction-SSCP analysis and direct sequencing demonstrated a G--&gt;T transversion at the third position of p53 codon 130, with the resultant substitution of asparagine for lysine, in one of the 10 carcinomas induced by 100 ppm of PhIP for which freshly frozen samples were available.	Asparagine	179-189	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	129-132
8167156-0	1994	Alteration by transforming growth factor-beta 1 of asparagine-linked sugar chains in glucose transporter protein in Swiss 3T3 cells.	Asparagine	51-61	transforming growth factor, beta 1	Mus musculus	14-47
8171029-1	1994	Rhodopsin, the dim light photoreceptor of the rod cell, is an integral membrane protein that is glycosylated at Asn-2 and Asn-15.	Asparagine	112-115	rhodopsin	Bos taurus	0-9
8175686-6	1994	Insulin-induced Raf hyperphosphorylation was inhibited by expression of an inducible dominant negative Ras mutant (Asn-17).	Asparagine	115-118	zinc fingers and homeoboxes 2	Mus musculus	16-19
8171029-1	1994	Rhodopsin, the dim light photoreceptor of the rod cell, is an integral membrane protein that is glycosylated at Asn-2 and Asn-15.	Asparagine	122-125	rhodopsin	Bos taurus	0-9
7958085-4	1994	The long extracellular domain of the TSHR has 5 or 6 possible asparagine-linked glycosylation sites.	Asparagine	62-72	thyroid stimulating hormone receptor	Homo sapiens	37-41
8166714-2	1994	Majority of alpha 2PI purified from plasma was the previously recognized plasma alpha 2PI with NH2-terminal Asn (Asn-alpha 2PI), whereas majority of alpha 2PI purified from the culture media was retaining the "pro" peptide of 12 amino acids with NH2-terminal Met (Met-alpha 2PI).	Asparagine	108-111	serpin family F member 2	Homo sapiens	80-89
8166714-2	1994	Majority of alpha 2PI purified from plasma was the previously recognized plasma alpha 2PI with NH2-terminal Asn (Asn-alpha 2PI), whereas majority of alpha 2PI purified from the culture media was retaining the "pro" peptide of 12 amino acids with NH2-terminal Met (Met-alpha 2PI).	Asparagine	108-111	serpin family F member 2	Homo sapiens	80-89
8163165-4	1994	We also show that the mutations responsible for Rm resistance in four independent drr2dom alleles alter the identical aa (Ser1975--&gt;Arg) previously identified in drr1dom mutants (Ser1972--&gt;Arg or Asn).	Asparagine	202-205	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	165-169
8176895-6	1994	RESULTS: Ultrastructurally, amyloid-like fibrils were formed from the mutant Asn-187 and Tyr-187 gelsolin peptides corresponding to the naturally occurring missense mutations found in familial gelsolin amyloidosis syndromes, as well as from a gelsolin peptide having a Val-187 substitution.	Asparagine	77-80	gelsolin	Homo sapiens	193-201
8176895-10	1994	CONCLUSIONS: We have defined the amyloidogenic region of gelsolin to a 9-residue sequence in the highly conserved repetitive motif B and showed that residue 187 represents a critical site where a substitution of an amino acid with a charged side chain (Asp) with an amino acid with an uncharged (Asn) or hydrophobic side chain (Tyr, Val) creates a conformation that is highly amyloidogenic thus providing an explanation for the amyloidogenicity of the Asn-187 and Tyr-187 gelsolin variants.	Asparagine	296-299	gelsolin	Homo sapiens	57-65
8176895-10	1994	CONCLUSIONS: We have defined the amyloidogenic region of gelsolin to a 9-residue sequence in the highly conserved repetitive motif B and showed that residue 187 represents a critical site where a substitution of an amino acid with a charged side chain (Asp) with an amino acid with an uncharged (Asn) or hydrophobic side chain (Tyr, Val) creates a conformation that is highly amyloidogenic thus providing an explanation for the amyloidogenicity of the Asn-187 and Tyr-187 gelsolin variants.	Asparagine	452-455	gelsolin	Homo sapiens	57-65
8175708-7	1994	The Wbp1 and Swp1 proteins were previously shown to be essential for asparagine-linked glycosylation in vivo.	Asparagine	69-79	dolichyl-diphosphooligosaccharide-protein glycotransferase	Saccharomyces cerevisiae S288C	4-8
8175708-7	1994	The Wbp1 and Swp1 proteins were previously shown to be essential for asparagine-linked glycosylation in vivo.	Asparagine	69-79	dolichyl-diphosphooligosaccharide-protein glycotransferase	Saccharomyces cerevisiae S288C	13-17
8166714-2	1994	Majority of alpha 2PI purified from plasma was the previously recognized plasma alpha 2PI with NH2-terminal Asn (Asn-alpha 2PI), whereas majority of alpha 2PI purified from the culture media was retaining the "pro" peptide of 12 amino acids with NH2-terminal Met (Met-alpha 2PI).	Asparagine	108-111	serpin family F member 2	Homo sapiens	80-89
8166714-2	1994	Majority of alpha 2PI purified from plasma was the previously recognized plasma alpha 2PI with NH2-terminal Asn (Asn-alpha 2PI), whereas majority of alpha 2PI purified from the culture media was retaining the "pro" peptide of 12 amino acids with NH2-terminal Met (Met-alpha 2PI).	Asparagine	108-111	serpin family F member 2	Homo sapiens	80-89
8172593-1	1994	The residue asparagine-52 of rat cytochrome c and baker"s yeast iso-1-cytochrome c was mutated to isoleucine by site-directed mutagenesis, and the unfolding of the wild-type and mutant proteins in urea or guanidinium chloride solutions was studied.	Asparagine	12-22	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	64-69
8172593-4	1994	These results probably reflect structural differences between yeast iso-1 and vertebrate cytochromes c in the vicinity of the Asn-52 side chain.	Asparagine	126-129	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	68-73
8156595-4	1994	Interestingly, while fragile X syndrome is usually caused by lack of FMR1 expression, a previously reported mutation in a highly conserved residue of one of its two KH domains (Ile-304--&gt;Asn) also results in mental retardation.	Asparagine	190-193	fragile X messenger ribonucleoprotein 1	Homo sapiens	69-73
8143731-9	1994	Remarkably, a reversed differential binding was observed after substitution at position 143 in hTNF; replacing Asp by non-conservative residues such as Tyr, Phe or Asn resulted in a much larger decrease in binding to R55 than to R75.	Asparagine	164-167	tumor necrosis factor	Homo sapiens	95-99
7510519-4	1994	Asn-85, Asn-89, Tyr-92, and Asn-96 in the second transmembrane domain and Tyr-287 in the seventh transmembrane domain are required for the high-affinity binding of peptides, with Asn-85 possibly interacting with the C-terminus of substance P.	Asparagine	0-3	tachykinin precursor 1	Homo sapiens	230-241
7510519-4	1994	Asn-85, Asn-89, Tyr-92, and Asn-96 in the second transmembrane domain and Tyr-287 in the seventh transmembrane domain are required for the high-affinity binding of peptides, with Asn-85 possibly interacting with the C-terminus of substance P.	Asparagine	8-11	tachykinin precursor 1	Homo sapiens	230-241
7510519-4	1994	Asn-85, Asn-89, Tyr-92, and Asn-96 in the second transmembrane domain and Tyr-287 in the seventh transmembrane domain are required for the high-affinity binding of peptides, with Asn-85 possibly interacting with the C-terminus of substance P.	Asparagine	8-11	tachykinin precursor 1	Homo sapiens	230-241
7510519-4	1994	Asn-85, Asn-89, Tyr-92, and Asn-96 in the second transmembrane domain and Tyr-287 in the seventh transmembrane domain are required for the high-affinity binding of peptides, with Asn-85 possibly interacting with the C-terminus of substance P.	Asparagine	8-11	tachykinin precursor 1	Homo sapiens	230-241
8135762-5	1994	Examination of the crystal structure of the thrombin-hirudin complex suggested the possibility that ionic interactions that would increase binding energy could be engineered by mutating Ser-19, Asn-20 and Gln-49 to acidic residues.	Asparagine	194-197	coagulation factor II, thrombin	Homo sapiens	44-52
7984276-3	1994	In the case of the human 5-HT1D beta receptor, replacement of this T with asparagine (N), dramatically increases its ability to bind beta-adrenergic antagonists.	Asparagine	74-84	5-hydroxytryptamine receptor 1B	Homo sapiens	25-36
8026990-8	1994	Moreover, A26.1, A26.3, A10SA, and A43 share 76 alanine and 77 asparagine, which is consistent with the reported serologic cross-reactivity.	Asparagine	63-73	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	10-13
8026990-8	1994	Moreover, A26.1, A26.3, A10SA, and A43 share 76 alanine and 77 asparagine, which is consistent with the reported serologic cross-reactivity.	Asparagine	63-73	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	17-20
7998343-5	1994	D-ornithine side chain prolongation by means of the attachment of some amino acid residues (methionine, leucine, proline, asparagine) led to the original branched enkephalin analogs.	Asparagine	122-132	proenkephalin	Rattus norvegicus	163-173
8179819-4	1994	Analysis of the expression of wild-type GRP94 and the mutant proteins has revealed that Asn-196 is the acceptor site used in normal glycosylation of GRP94 and that hyperglycosylation is dependent upon the level of expression of the GRP94 and is occurring at acceptor sites in the carboxy-terminal region of the protein.	Asparagine	88-91	heat shock protein 90, beta (Grp94), member 1	Mus musculus	40-45
8106386-7	1994	Mutations of Asp into Asn in the NH2-terminal segment of C5aR further indicated that negative charges are required to endow the receptor with a C5a binding capacity.	Asparagine	22-25	complement C5a receptor 1	Homo sapiens	57-61
8106386-7	1994	Mutations of Asp into Asn in the NH2-terminal segment of C5aR further indicated that negative charges are required to endow the receptor with a C5a binding capacity.	Asparagine	22-25	complement C5a receptor 1	Homo sapiens	57-60
8179819-4	1994	Analysis of the expression of wild-type GRP94 and the mutant proteins has revealed that Asn-196 is the acceptor site used in normal glycosylation of GRP94 and that hyperglycosylation is dependent upon the level of expression of the GRP94 and is occurring at acceptor sites in the carboxy-terminal region of the protein.	Asparagine	88-91	heat shock protein 90, beta (Grp94), member 1	Mus musculus	149-154
8179819-4	1994	Analysis of the expression of wild-type GRP94 and the mutant proteins has revealed that Asn-196 is the acceptor site used in normal glycosylation of GRP94 and that hyperglycosylation is dependent upon the level of expression of the GRP94 and is occurring at acceptor sites in the carboxy-terminal region of the protein.	Asparagine	88-91	heat shock protein 90, beta (Grp94), member 1	Mus musculus	149-154
8172556-7	1993	The insect cells are able to beta-hydroxylate the Asn residue of the EGF domain in the C1r but with a low efficiency.	Asparagine	50-53	complement C1r	Homo sapiens	87-90
8174273-0	1994	Alteration of asparagine-linked glycosylation in serum transferrin of patients with hepatocellular carcinoma.	Asparagine	14-24	transferrin	Homo sapiens	55-66
8174273-1	1994	The asparagine-linked sugar chains in serum transferrin purified from patients with hepatocellular carcinoma (n = 13), healthy individuals (n = 5) and patients with liver cirrhosis (n = 6) were compared.	Asparagine	4-14	transferrin	Homo sapiens	44-55
7866721-9	1994	The insect cells are able to beta-hydroxylate the Asn residue of the EGF domain in the C1r but with a low efficiency.	Asparagine	50-53	complement C1r	Homo sapiens	87-90
8190022-1	1994	The in vitro effect of a hypoglycaemic fragment of human growth hormone containing the sequence H2N-Leu-Ser-Arg-Leu-Phe-Asu11-Asn-Ala-COOH (Asu11-hGH 6-13) on tyrosine kinase of rat hepatic insulin receptors was examined.	Asparagine	126-129	growth hormone 1	Homo sapiens	57-71
8302276-4	1994	Similar to the cloned rodent 5-HT1B receptors, it had high affinity for the beta-adrenergic ligand [125I]iodocyanopindolol, because of the presence of an asparagine instead of a threonine residue in the seventh transmembrane region.	Asparagine	154-164	5-hydroxytryptamine receptor 1B	Homo sapiens	29-35
8265660-6	1993	Transfection of cells with HLA-C alleles encoding Asn-77-Lys-80 (including HLA-Cw4, -Cw5, and -Cw6) inhibited the lysis of the targets by NK1-specific NK cells, whereas HLA-C alleles encoding Ser-77-Asn-80 (including HLA-Cw1, -Cw7, and -Cw13) protected the targets from NK2-specific NK cells.	Asparagine	50-53	major histocompatibility complex, class I, C	Homo sapiens	27-32
8265660-6	1993	Transfection of cells with HLA-C alleles encoding Asn-77-Lys-80 (including HLA-Cw4, -Cw5, and -Cw6) inhibited the lysis of the targets by NK1-specific NK cells, whereas HLA-C alleles encoding Ser-77-Asn-80 (including HLA-Cw1, -Cw7, and -Cw13) protected the targets from NK2-specific NK cells.	Asparagine	50-53	tachykinin receptor 1	Homo sapiens	138-141
8265660-6	1993	Transfection of cells with HLA-C alleles encoding Asn-77-Lys-80 (including HLA-Cw4, -Cw5, and -Cw6) inhibited the lysis of the targets by NK1-specific NK cells, whereas HLA-C alleles encoding Ser-77-Asn-80 (including HLA-Cw1, -Cw7, and -Cw13) protected the targets from NK2-specific NK cells.	Asparagine	50-53	major histocompatibility complex, class I, C	Homo sapiens	75-80
8265660-6	1993	Transfection of cells with HLA-C alleles encoding Asn-77-Lys-80 (including HLA-Cw4, -Cw5, and -Cw6) inhibited the lysis of the targets by NK1-specific NK cells, whereas HLA-C alleles encoding Ser-77-Asn-80 (including HLA-Cw1, -Cw7, and -Cw13) protected the targets from NK2-specific NK cells.	Asparagine	50-53	NK2 homeobox 1	Homo sapiens	270-273
8274017-1	1993	The asparagine-linked sugar chains of blood coagulation factor VIII purified from porcine plasma were released as oligosaccharides by hydrazinolysis.	Asparagine	4-14	coagulation factor VIII	Homo sapiens	44-67
8031011-4	1994	The substitution of neutral asparagine for anionic aspartic acid is consistent with the more cathodal electrophoretic migration of ADA 2 as compared with ADA 1.	Asparagine	28-38	transcriptional adaptor 2A	Homo sapiens	131-136
8031011-4	1994	The substitution of neutral asparagine for anionic aspartic acid is consistent with the more cathodal electrophoretic migration of ADA 2 as compared with ADA 1.	Asparagine	28-38	transcriptional adaptor 1	Homo sapiens	154-159
8188629-2	1994	The antibody was raised against the phosphorylated synthetic peptide, Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-phospho-Ser-Asn-Val-Phe-Cys (residues 11-22 of the myosin light chain).	Asparagine	114-117	myosin heavy chain 14	Homo sapiens	153-159
8188630-0	1994	Histidinol dehydrogenase loses its catalytic function through the mutation of His261--&gt;Asn due to its inability to ligate the essential Zn.	Asparagine	90-93	histidinol dehydrogenase, chloroplastic	Brassica oleracea	0-24
8019599-1	1994	The human erythrocyte anion transporter (band 3; AE1) has a single N-linked glycosylation site at amino residue Asn-642.	Asparagine	112-115	solute carrier family 4 member 1 (Diego blood group) L homeolog	Xenopus laevis	41-47
8019599-1	1994	The human erythrocyte anion transporter (band 3; AE1) has a single N-linked glycosylation site at amino residue Asn-642.	Asparagine	112-115	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	49-52
8253759-7	1993	In contrast, combining the Asp143--&gt;Asn and Ala145--&gt;Arg mutations (D143N-A145R) resulted in a complete loss of binding to the 55-kDa TNF receptor, whereas binding to the 75-kDa TNF receptor was impaired by only 5-10-fold.	Asparagine	39-42	tumor necrosis factor	Homo sapiens	140-143
8138033-13	1993	Furthermore, all the amino acid replacements correspond to single point DNA mutations and (with the exception of the substitution Asp 22--&gt;Asn in the beta 2-globin) involve uncharged substitutions.	Asparagine	142-145	beta globin minor gene	Rattus norvegicus	153-166
8243674-1	1993	We have changed one of the carbohydrate-bearing asparagine residues of human antithrombin to glutamine by site-directed mutagenesis and expressed the variant antithrombin, N135Q, in baby hamster kidney cells.	Asparagine	48-58	serpin family C member 1	Homo sapiens	77-89
8138548-2	1993	Our previous study showed that the Asn-linked sugar chains of bovine CD36 prepared from milk fat globule membranes (MFGM) contain this unique monosaccharide as the GalNAc beta 1--&gt;4GlcNAc group [Nakata et al.	Asparagine	35-38	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	116-120
8138548-7	1993	These results indicated that many bovine MFGM glycoproteins contain Asn-linked sugar chains with the GalNAc beta 1--&gt;4GlcNAc group.	Asparagine	68-71	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	41-45
8301235-0	1993	Functional role of N-linked glycosylation in human hepatic lipase: asparagine-56 is important for both enzyme activity and secretion.	Asparagine	67-77	lipase C, hepatic type	Homo sapiens	51-65
8301235-3	1993	Human HL is a glycoprotein and its predicted amino acid sequence contains four putative N-linked glycosylation sites at Asn residues 20, 56, 340, and 375.	Asparagine	120-123	hes family bHLH transcription factor 1	Homo sapiens	6-8
8138529-9	1993	The nonglycosylated asparagine site of S2 was elucidated to be random by high performance liquid chromatography-ESI/MS of a tryptic peptide of reduced and pyridylethylated S2.ESI/MS analysis of transferrin purified through one step from serum is applicable for a definite diagnosis of the CDG syndrome.	Asparagine	20-30	transferrin	Homo sapiens	194-205
8133203-1	1993	The gonadotrophin-releasing hormone (GnRH) receptor is unlike other G-protein coupled receptors in that the highly conserved amino acids, Asp in the second transmembrane region and Asn in the seventh, are interchanged.	Asparagine	181-184	gonadotropin releasing hormone receptor	Rattus norvegicus	4-51
8301235-10	1993	The fact that the homologous N-linked glycosylation site (Asn-43) is required for both enzyme activity and secretion for human LPL (Semenkovich et al.	Asparagine	58-61	lipoprotein lipase	Homo sapiens	127-130
12232020-6	1993	Furthermore, amino acid analysis revealed a 10- to 100-fold increase in free asparagine in leaves of transgenic 35S-AS1 plants (construct z127) compared with controls.	Asparagine	77-87	transcription factor AS1-like	Nicotiana tabacum	116-119
12232020-10	1993	The 3- to 19-fold increase in asparagine levels in the transgenic plants expressing gln[delta]AS1 compared with wild type suggests that the novel AS holoenzyme present in the transgenic plants (gln[delta]AS1 homodimer) has enhanced ammonia-dependent activity.	Asparagine	30-40	transcription factor AS1-like	Nicotiana tabacum	94-97
12232020-10	1993	The 3- to 19-fold increase in asparagine levels in the transgenic plants expressing gln[delta]AS1 compared with wild type suggests that the novel AS holoenzyme present in the transgenic plants (gln[delta]AS1 homodimer) has enhanced ammonia-dependent activity.	Asparagine	30-40	transcription factor AS1-like	Nicotiana tabacum	204-207
8251489-2	1993	The asparagine-linked sugar chains were released as oligosaccharides from purified CD45 by hydrazinolysis.	Asparagine	4-14	protein tyrosine phosphatase receptor type C	Homo sapiens	83-87
8308464-4	1993	Dogfish angiotensin I is teleost-like because of an asparagine residue at position 1 but it is mammalian-like because of an isoleucine residue at position 5.	Asparagine	52-62	angiotensinogen	Homo sapiens	8-21
8250906-2	1993	The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr &gt; Ser &gt; Gly &gt; Gln &gt; Cys &gt; Asn &gt; Asp &gt; Val &gt; Phe &gt; Glu &gt; Lys &gt; Tyr &gt; Ala = Trp &gt; His &gt; Arg, suggesting the importance of end capping.	Asparagine	144-147	neuropeptide Y	Homo sapiens	59-62
8223431-3	1993	COS-1 cells transfected with XFGF3 cDNA express a 31 kDa product, p31, generated by signal peptide cleavage and Asn-linked glycosylation at the single consensus site.	Asparagine	112-115	fibroblast growth factor 3 L homeolog	Xenopus laevis	29-34
8223431-3	1993	COS-1 cells transfected with XFGF3 cDNA express a 31 kDa product, p31, generated by signal peptide cleavage and Asn-linked glycosylation at the single consensus site.	Asparagine	112-115	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	Mus musculus	66-69
8111231-6	1993	Overall structures with the lowest target penalty function were similar between the two forms, having a beta-turn structure at the endocyclic residues of the Tyr-Ile-Gln-Asn moiety.	Asparagine	170-173	amyloid beta precursor protein	Homo sapiens	102-108
8240107-5	1993	It was a single base-pair transversion (AAT to AGT) leading to a serine-for-asparagine substitution.	Asparagine	76-86	serpin family A member 1	Homo sapiens	40-43
8240107-5	1993	It was a single base-pair transversion (AAT to AGT) leading to a serine-for-asparagine substitution.	Asparagine	76-86	angiotensinogen	Homo sapiens	47-50
8399210-2	1993	The nucleotide sequence of UDPGTh-3 encodes a 530 amino acid protein with a typical membrane insertion-signal peptide, a membrane-anchoring domain, and three potential asparagine-linked glycosylation sites.	Asparagine	168-178	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	27-35
8254337-1	1993	The pentapeptide fragment of ANF, Asn-Ser-Phe-Arg-Tyr-NH2, coordinates to Cu(II) using the same four nitrogen donor centers as simple pentapeptides such as pentaalanine yet the complexes are of much higher stability as a result of a highly organized side-chain structure which is present in the complex but absent from the free ligand.	Asparagine	34-38	natriuretic peptide A	Homo sapiens	29-32
8407981-5	1993	Since the P-450(arom) molecule has two potential glycosylation sites (Asn-12 and Asn-180), we replaced each of the 2 asparagine residues with alanine by site-directed mutagenesis and examined the glycosylation of the two mutant proteins in the cell-free system.	Asparagine	70-73	PARP1 binding protein	Homo sapiens	10-21
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Asparagine	85-88	rhodopsin	Homo sapiens	4-13
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Asparagine	85-88	rhodopsin	Homo sapiens	24-33
8407981-5	1993	Since the P-450(arom) molecule has two potential glycosylation sites (Asn-12 and Asn-180), we replaced each of the 2 asparagine residues with alanine by site-directed mutagenesis and examined the glycosylation of the two mutant proteins in the cell-free system.	Asparagine	81-84	PARP1 binding protein	Homo sapiens	10-21
8407981-7	1993	These results demonstrated that the potential glycosylation site (Asn-12) in the N-terminal portion of P-450(arom) is the site of glycosylation.	Asparagine	66-69	PARP1 binding protein	Homo sapiens	103-114
8104863-4	1993	The codon for asparagine was converted from AAT to AAC.	Asparagine	14-24	serpin family A member 1	Homo sapiens	44-47
7804366-4	1993	The data showed that a single amino acid substitution of tyrosine by phenylalanine and a number of amino acids including serine, asparagine, histidine and arginine at position 97 in the VH CDR3 region all resulted in approximate 18-fold lower binding affinity, whereas the substitution of tyrosine by phenylalanine at position 96 in the VH CDR3 region did not affect the binding affinity of the cB72.3m4 antibody.	Asparagine	129-139	cerebellar degeneration-related 3	Mus musculus	189-193
8104863-4	1993	The codon for asparagine was converted from AAT to AAC.	Asparagine	14-24	glycine-N-acyltransferase	Homo sapiens	51-54
7690587-2	1993	Single amino acid variants of bovine pancreatic trypsin inhibitor (BPTI) have been made with glycine or alanine replacement of residues Tyr 35, Gly 37, Asn 43, and Asn 44.	Asparagine	152-155	spleen trypsin inhibitor I	Bos taurus	30-65
8251940-0	1993	In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV.	Asparagine	64-67	calmodulin	Bos taurus	18-28
8413213-13	1993	The gene for PUB1 was cloned and sequenced, and the sequence was found to predict a 51-kDa protein with three ribonucleoprotein consensus RNA-binding domains and three glutamine- and asparagine-rich auxiliary domains.	Asparagine	183-193	Pub1p	Saccharomyces cerevisiae S288C	13-17
8376387-13	1993	Recombinant SPC3 was also able to cleave after a single arginine residue in chicken proalbumin following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence.	Asparagine	113-116	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
7690587-2	1993	Single amino acid variants of bovine pancreatic trypsin inhibitor (BPTI) have been made with glycine or alanine replacement of residues Tyr 35, Gly 37, Asn 43, and Asn 44.	Asparagine	152-155	spleen trypsin inhibitor I	Bos taurus	67-71
8375504-0	1993	Asparagine-135 of elongation factor Tu is a crucial residue for the folding of the guanine nucleotide binding pocket.	Asparagine	0-10	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	18-38
7690587-2	1993	Single amino acid variants of bovine pancreatic trypsin inhibitor (BPTI) have been made with glycine or alanine replacement of residues Tyr 35, Gly 37, Asn 43, and Asn 44.	Asparagine	164-167	spleen trypsin inhibitor I	Bos taurus	30-65
7690587-2	1993	Single amino acid variants of bovine pancreatic trypsin inhibitor (BPTI) have been made with glycine or alanine replacement of residues Tyr 35, Gly 37, Asn 43, and Asn 44.	Asparagine	164-167	spleen trypsin inhibitor I	Bos taurus	67-71
8403382-2	1993	We compared the effects of asparagine, an amino acid previously shown to increase ODC activity in adult hippocampal slices, on ODC mRNA and activity in adult and neonatal hippocampal slices.	Asparagine	27-37	ornithine decarboxylase 1	Rattus norvegicus	82-85
8369294-0	1993	Exclusion of 2"-deoxycytidine 5"-monophosphate by asparagine 229 of thymidylate synthase.	Asparagine	50-60	thymidylate synthetase	Homo sapiens	68-88
8369294-1	1993	In thymidylate synthase (TS, EC 2.1.1.45), the only side chain in direct hydrogen bonding with the pyrimidine ring of the substrate dUMP is asparagine 229 (N229).	Asparagine	140-150	thymidylate synthetase	Homo sapiens	3-23
8307787-5	1993	Negativity for the NK-1 specificity corresponded to the presence of asparagine and lysine at positions 77 and 80, respectively, in the second exon of HLA-C (alleles Cw2, 4, 5, and 6), while negativity for the NK-2 group corresponded to the presence of serine and asparagine, respectively, at these two positions (alleles Cw1, 3, 7, and 8).	Asparagine	68-78	tachykinin receptor 1	Homo sapiens	19-23
8307787-5	1993	Negativity for the NK-1 specificity corresponded to the presence of asparagine and lysine at positions 77 and 80, respectively, in the second exon of HLA-C (alleles Cw2, 4, 5, and 6), while negativity for the NK-2 group corresponded to the presence of serine and asparagine, respectively, at these two positions (alleles Cw1, 3, 7, and 8).	Asparagine	263-273	tachykinin receptor 1	Homo sapiens	19-23
8395013-5	1993	The key features that distinguished the NGFI-B and SF-1 interactions were an amino group in the minor groove of the SF-1 binding sequence and an asparagine in the SF-1 A box.	Asparagine	145-155	nuclear receptor subfamily 4 group A member 1	Homo sapiens	40-46
8395013-5	1993	The key features that distinguished the NGFI-B and SF-1 interactions were an amino group in the minor groove of the SF-1 binding sequence and an asparagine in the SF-1 A box.	Asparagine	145-155	nuclear receptor subfamily 5 group A member 1	Homo sapiens	51-55
8408427-1	1993	Ion-spray triple quadrupole mass spectrometry and high-performance liquid chromatography were used to investigate the products from the solid phase synthesis of (H)-Leu-Thr-Glu-Asn-(OH), a TNF-alpha active-site probe.	Asparagine	177-180	tumor necrosis factor	Homo sapiens	189-198
8244393-4	1993	In two patients with the autosomal recessive disease glucose/galactose malabsorption, the underlying cause was found to be a missense mutation in SGLT1, and the Asp28--&gt;Asn change was demonstrated in vitro to eliminate SGLT1 transport activity.	Asparagine	172-175	solute carrier family 5 member 1	Homo sapiens	146-151
8244393-4	1993	In two patients with the autosomal recessive disease glucose/galactose malabsorption, the underlying cause was found to be a missense mutation in SGLT1, and the Asp28--&gt;Asn change was demonstrated in vitro to eliminate SGLT1 transport activity.	Asparagine	172-175	solute carrier family 5 member 1	Homo sapiens	222-227
7688820-2	1993	Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT--&gt;AAT, Ser--&gt;Asn; designated 375 S/N).	Asparagine	207-210	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	18-23
7688820-2	1993	Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT--&gt;AAT, Ser--&gt;Asn; designated 375 S/N).	Asparagine	207-210	endogenous retrovirus group K member 20	Homo sapiens	38-41
7688820-2	1993	Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT--&gt;AAT, Ser--&gt;Asn; designated 375 S/N).	Asparagine	207-210	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	162-167
8284256-3	1993	The primary structure of the peptide (pGlu-Leu-His-Val-Asn-Lys-Ala-Arg-Arg-Pro-Tyr-Ile-Leu) is identical to that of chicken neurotensin.	Asparagine	55-58	neurotensin	Gallus gallus	124-135
8349598-2	1993	The peptide motif ProXaaArg/Lys (PXR/K), which is recognized by a PXR/K-specific GalNAc-transferase, is present in each of these glycoproteins 6-9 residues NH2-terminal to an Asn glycosylation site.	Asparagine	175-178	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
8349598-2	1993	The peptide motif ProXaaArg/Lys (PXR/K), which is recognized by a PXR/K-specific GalNAc-transferase, is present in each of these glycoproteins 6-9 residues NH2-terminal to an Asn glycosylation site.	Asparagine	175-178	nuclear receptor subfamily 1 group I member 2	Homo sapiens	66-69
8403382-2	1993	We compared the effects of asparagine, an amino acid previously shown to increase ODC activity in adult hippocampal slices, on ODC mRNA and activity in adult and neonatal hippocampal slices.	Asparagine	27-37	ornithine decarboxylase 1	Rattus norvegicus	127-130
8403382-4	1993	Asparagine produced an increase in ODC gene expression and activity in both adult and neonatal hippocampal slices.	Asparagine	0-10	ornithine decarboxylase 1	Rattus norvegicus	35-38
8403382-5	1993	The increase in ODC activity elicited by asparagine in hippocampal slices was the same in control animals as in animals sacrificed 16 h after KA-induced seizure activity.	Asparagine	41-51	ornithine decarboxylase 1	Rattus norvegicus	16-19
8403382-6	1993	The asparagine-elicited increase in ODC activity in neonatal and adult hippocampal slices was blocked by the RNA synthesis inhibitor, actinomycin D.	Asparagine	4-14	ornithine decarboxylase 1	Rattus norvegicus	36-39
8264574-2	1993	Especially the synthetic peptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn comprising the carboxy-terminal acidic hepta-peptide of the largest subunit of RNA polymerase II was found to serve as an excellent substrate for purified CKII.	Asparagine	65-68	casein kinase 2 alpha 1	Homo sapiens	224-228
8344413-4	1993	Cathepsin B prefers large hydrophobic residues in the P1" position of a substrate while cathepsin L has an opposite trend, favoring amino acids with small (Ala, Ser) or long but non-branched (Asn, Gln, Lys) side chains.	Asparagine	192-195	cathepsin B	Homo sapiens	0-11
8344916-8	1993	The difference between pI 6.0 L-FABP and pI 7.0 L-FABP was attributed to an asparagine-aspartate exchange at position 105.	Asparagine	76-86	fatty acid binding protein 1	Bos taurus	30-36
8344916-8	1993	The difference between pI 6.0 L-FABP and pI 7.0 L-FABP was attributed to an asparagine-aspartate exchange at position 105.	Asparagine	76-86	fatty acid binding protein 1	Bos taurus	48-54
8344413-4	1993	Cathepsin B prefers large hydrophobic residues in the P1" position of a substrate while cathepsin L has an opposite trend, favoring amino acids with small (Ala, Ser) or long but non-branched (Asn, Gln, Lys) side chains.	Asparagine	192-195	cathepsin L	Homo sapiens	88-99
8104555-4	1993	Here we report a comparative analysis of the site-specific N-glycosylation patterns from rat (Asn 23, 74, 98), mouse (Asn 23, 75, 99) and human (Asn 23, 60, 100) neural Thy-1.	Asparagine	94-97	Thy-1 cell surface antigen	Homo sapiens	169-174
8102140-1	1993	Cys-1 mutants of recombinant human asparagine synthetase were constructed and their ability to catalyze the glutamine-dependent nitrogen transfer reaction required for asparagine biosynthesis was determined.	Asparagine	35-45	cystin 1	Homo sapiens	0-5
15335687-3	1993	Curiously, the mammalian protease PC2, a Kex2 homolog that is likely to be required for pro-insulin processing, has an aspartate in place of asparagine at the "oxyanion hole".	Asparagine	141-151	proprotein convertase subtilisin/kexin type 2	Homo sapiens	34-37
8104555-4	1993	Here we report a comparative analysis of the site-specific N-glycosylation patterns from rat (Asn 23, 74, 98), mouse (Asn 23, 75, 99) and human (Asn 23, 60, 100) neural Thy-1.	Asparagine	118-121	Thy-1 cell surface antigen	Homo sapiens	169-174
8104555-4	1993	Here we report a comparative analysis of the site-specific N-glycosylation patterns from rat (Asn 23, 74, 98), mouse (Asn 23, 75, 99) and human (Asn 23, 60, 100) neural Thy-1.	Asparagine	118-121	Thy-1 cell surface antigen	Homo sapiens	169-174
8234236-1	1993	The highly conserved asparagine residue at position 32 (Asn32) in the "hinge" region of epidermal growth factor (EGF) separates the N- and C-terminal structural motifs of the EGF molecule and is therefore an appropriate target for structure-function studies.	Asparagine	21-31	epidermal growth factor	Homo sapiens	113-116
8102146-4	1993	Cyanogen bromide peptide mapping and DNA restriction length polymorphism analyses showed that the propositus was a compound heterozygote for two TTR variants: Asn 90 and Met 119.	Asparagine	159-162	transthyretin	Homo sapiens	145-148
8102146-5	1993	Family analysis revealed that he inherited the TTR Met 119 variant from the mother and the TTR Asn 90 variant from the father.	Asparagine	95-98	transthyretin	Homo sapiens	91-94
8234236-1	1993	The highly conserved asparagine residue at position 32 (Asn32) in the "hinge" region of epidermal growth factor (EGF) separates the N- and C-terminal structural motifs of the EGF molecule and is therefore an appropriate target for structure-function studies.	Asparagine	21-31	epidermal growth factor	Homo sapiens	175-178
15335687-4	1993	RESULTS: We have tested the effect of making substitutions of the conserved oxyanion-hole asparagine (Asn 314) of the Kex2 protease.	Asparagine	90-100	kexin KEX2	Saccharomyces cerevisiae S288C	118-122
15335687-4	1993	RESULTS: We have tested the effect of making substitutions of the conserved oxyanion-hole asparagine (Asn 314) of the Kex2 protease.	Asparagine	102-105	kexin KEX2	Saccharomyces cerevisiae S288C	118-122
8332195-5	1993	Raf-GST interacts with wild-type and oncogenic Ras (Val 12) but fails to interact with a biologically inert effector mutant of Ras (Ala 38) and a dominant negative mutant (Asn 17).	Asparagine	172-175	zinc fingers and homeoboxes 2	Homo sapiens	0-3
7688509-1	1993	An anti-peptide antibody was raised against the sequence Thr-Gly-Ala-Leu-Phe-Lys-His-Ser-Glu-Asn-Tyr-Lys which occurs at positions 283-294 in the rat cytochrome P450 enzyme CYP1A2.	Asparagine	93-96	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179
8405897-6	1993	The sequence His-Ala-Asp-Gly-Thr5-Phe-Thr-Asn-Asp-Met10-Thr-Ser-Tyr- Leu-Asp15-Ala-Lys-Ala-Ala-Arg20-Asp-Phe-Val-Ser-Trp25- Leu-Ala-Arg-Ser-Asp30- Lys-Ser shows 16 amino acid substitutions compared with the corresponding region of mammalian GLP-1 and 15 substitutions compared with that of salmon GLP.	Asparagine	42-45	glucagon like peptide 1 receptor	Homo sapiens	241-246
7687165-1	1993	We recently identified ABO(H) blood group structures in Asn-linked sugar chains of human von Willebrand factor (vWF) purified from factor VIII concentrates (J Biol Chem 267:8723, 1992).	Asparagine	56-59	von Willebrand factor	Homo sapiens	89-110
7687165-1	1993	We recently identified ABO(H) blood group structures in Asn-linked sugar chains of human von Willebrand factor (vWF) purified from factor VIII concentrates (J Biol Chem 267:8723, 1992).	Asparagine	56-59	von Willebrand factor	Homo sapiens	112-115
8393577-5	1993	Electron density for the crystal structure of cathepsin D indicated the presence of an N-linked oligosaccharide that extends from Asn-70 toward Lys-203, which is a key component of the phosphotransferase recognition region, and thus provides a structural explanation for how the phosphotransferase can recognize apparently distant sites on the protein surface.	Asparagine	130-133	cathepsin D	Homo sapiens	46-57
8325883-5	1993	The sequence of the putative RBP1 protein contains two copies of an RNA recognition motif, two glutamine stretches, an asparagine-rich region, a methionine-rich region, and two long potential alpha-helixes.	Asparagine	119-129	Sgn1p	Saccharomyces cerevisiae S288C	29-33
8329399-3	1993	When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected.	Asparagine	121-124	H3 histone pseudogene 16	Homo sapiens	58-61
8401258-4	1993	At the molecular level, IL-11 is unique, containing no asparagine-linked glycosylation sites and no cysteine residues.	Asparagine	55-65	interleukin 11	Homo sapiens	24-29
8509412-0	1993	A region of the C-terminal portion of the human transferrin receptor contains an asparagine-linked glycosylation site critical for receptor structure and function.	Asparagine	81-91	transferrin	Homo sapiens	48-59
8509412-3	1993	The effect of asparagine-linked glycosylation on the processing and cell surface localization of the human transferrin receptor is examined here by site-directed mutagenesis.	Asparagine	14-24	transferrin	Homo sapiens	107-118
8497072-4	1993	The substitution of a glutamine for an asparagine residue (Q-267) at a potential asparagine-linked glycosylation site in C2, which severely impairs virus infectivity, reduces intracellular processing of gp160 into gp120, the association of gp120 with virions, and the ability of gp120 to bind to the HIV-1 cell surface receptor protein, CD4.	Asparagine	39-49	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	203-208
8508780-7	1993	A protein splicing model is presented in which asparagine rearrangement initiates the self-excision of the spacer protein from the Tfp1 precursor.	Asparagine	47-57	H(+)-transporting V1 sector ATPase subunit A	Saccharomyces cerevisiae S288C	131-135
8370663-2	1993	Asparagine-linked sugar chains of yolk-RBP were liberated by hydrazinolysis.	Asparagine	0-10	retinol binding protein 4	Homo sapiens	39-42
7689367-0	1993	The Lewis x epitope is a major non-reducing structure in the sulphated N-glycans attached to Asn-65 of bovine pro-opiomelanocortin.	Asparagine	93-96	proopiomelanocortin	Bos taurus	110-130
7688581-1	1993	The epitope region on the TNF-alpha molecule recognized by monoclonal antibody (mAb) 3-D-6, which neutralizes the cytotoxic activity on murine LM cells, has been determined as Gly24-Gln-Leu-Gln-Trp-Leu-Asn-Arg31.	Asparagine	202-205	tumor necrosis factor	Mus musculus	26-35
8497072-4	1993	The substitution of a glutamine for an asparagine residue (Q-267) at a potential asparagine-linked glycosylation site in C2, which severely impairs virus infectivity, reduces intracellular processing of gp160 into gp120, the association of gp120 with virions, and the ability of gp120 to bind to the HIV-1 cell surface receptor protein, CD4.	Asparagine	39-49	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	214-219
8497072-4	1993	The substitution of a glutamine for an asparagine residue (Q-267) at a potential asparagine-linked glycosylation site in C2, which severely impairs virus infectivity, reduces intracellular processing of gp160 into gp120, the association of gp120 with virions, and the ability of gp120 to bind to the HIV-1 cell surface receptor protein, CD4.	Asparagine	39-49	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	240-245
8497072-4	1993	The substitution of a glutamine for an asparagine residue (Q-267) at a potential asparagine-linked glycosylation site in C2, which severely impairs virus infectivity, reduces intracellular processing of gp160 into gp120, the association of gp120 with virions, and the ability of gp120 to bind to the HIV-1 cell surface receptor protein, CD4.	Asparagine	39-49	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	240-245
8497072-4	1993	The substitution of a glutamine for an asparagine residue (Q-267) at a potential asparagine-linked glycosylation site in C2, which severely impairs virus infectivity, reduces intracellular processing of gp160 into gp120, the association of gp120 with virions, and the ability of gp120 to bind to the HIV-1 cell surface receptor protein, CD4.	Asparagine	81-91	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	203-208
8506360-2	1993	To determine whether this aspartic acid is also involved in the function of the rat vascular angiotensin II receptor subtype 1 (AT1a), Asp74 was replaced either by asparagine or by glutamic acid.	Asparagine	164-174	angiotensin II receptor, type 1a	Rattus norvegicus	128-132
8502242-5	1993	The total lack of carbohydrate found in the aglycosylated site-directed mutants human chimeric IgG4 B72.3 (Asn 297--&gt;Gln) and mouse IgG2b (Asn 297--&gt;Ala) demonstrates that there are no N-glycosylation sites other than Asn 297.	Asparagine	142-145	immunoglobulin heavy constant gamma 2B	Mus musculus	135-140
8502242-5	1993	The total lack of carbohydrate found in the aglycosylated site-directed mutants human chimeric IgG4 B72.3 (Asn 297--&gt;Gln) and mouse IgG2b (Asn 297--&gt;Ala) demonstrates that there are no N-glycosylation sites other than Asn 297.	Asparagine	142-145	immunoglobulin heavy constant gamma 2B	Mus musculus	135-140
8347808-3	1993	Furthermore, the replacement by glutamine or arginine of the conserved asparagine residue in segment M2 of the epsilon 2 and zeta 1 NMDA receptor channel subunits reduced the sensitivities to PCP, ketamine and SKF-10,047, though to different extents.	Asparagine	71-81	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	132-145
8494888-7	1993	To explore this hypothesis further, each of the four potential N-linked glycosylation sites of CETP (at amino acid positions 88, 240, 341, and 396) was eliminated by mutagenesis of asparagine to glutamine.	Asparagine	181-191	cholesteryl ester transfer protein	Homo sapiens	95-99
8503189-4	1993	To further explore the mechanism by which the Gag-Pol polyprotein is incorporated into virions, we have constructed a mutation which changes an aspartic acid in the protease active site to asparagine (pHXB2pro-); a four-amino-acid insertion into the protease gene (pHXB2Smal); and insertion of translational termination codons in the protease gene following the gag gene (pHXB55).	Asparagine	189-199	Pr55(Gag)	Human immunodeficiency virus 1	46-49
8493555-2	1993	Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77,Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen.	Asparagine	141-151	tachykinin receptor 1	Homo sapiens	39-43
8486673-5	1993	FAB-MS, electrospray-mass spectrometry, and linkage analysis demonstrated that each monomer of rat CRP contained one oligosaccharide chain, predominantly a disialylated biantennary structure, attached to Asn-128.	Asparagine	204-207	C-reactive protein	Rattus norvegicus	99-102
8493555-2	1993	Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77,Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen.	Asparagine	141-151	major histocompatibility complex, class I, C	Homo sapiens	130-135
8494888-0	1993	Human plasma cholesteryl ester transfer protein consists of a mixture of two forms reflecting variable glycosylation at asparagine 341.	Asparagine	120-130	cholesteryl ester transfer protein	Homo sapiens	13-47
8383676-5	1993	Analysis of the hydroxylamine-dependent cleavage of ubiquitin-Cdc34 conjugates at the single Asn-Gly sequence in Cdc34 placed the major ubiquitin linkage site within the C-terminal 215-295 residues of Cdc34.	Asparagine	93-96	ubiquitin	Saccharomyces cerevisiae S288C	52-61
8490167-5	1993	Mouse EPO-R is glycosylated at one asparagine residue in the extracellular region.	Asparagine	35-45	erythropoietin receptor	Mus musculus	6-11
8490167-6	1993	The mutant EPO-R, in which asparagine residue responsible for N-glycosylation was replaced with glutamine residue, was expressed on BHK cells.	Asparagine	27-37	erythropoietin receptor	Mesocricetus auratus	11-16
8502548-4	1993	Substitution of alanine -14 of GCN4 by either asparagine or cysteine changes the DNA binding specificity.	Asparagine	46-56	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	31-35
8332551-5	1993	In addition, the gamma-MSH sequence, contrary to salmon POMC, is present and contains three substitutions, namely a Ser, an Asn, and a Lys residue substituting the normally occurring mammalian Gly, Asp, and Arg residue, respectively.	Asparagine	124-127	proopiomelanocortin	Homo sapiens	17-26
8471052-6	1993	Molecular cloning demonstrated that the lymphoblastoid cell line which expressed GSTM1 possessed the b allelic variant (i.e. that with an asparagine residue at position 173).	Asparagine	138-148	glutathione S-transferase mu 1	Homo sapiens	81-86
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Asparagine	315-325	glycoprotein Ib platelet subunit alpha	Homo sapiens	87-96
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Asparagine	315-325	glycoprotein IX platelet	Homo sapiens	101-105
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Asparagine	315-325	glycoprotein IX platelet	Homo sapiens	175-179
8494607-6	1993	Asn to Ser mutations at one or both of the glycosylation sites of mature renin were made and the expression of these constructs was examined in COS, CHO, and Sf9 insect cells.	Asparagine	0-3	renin	Cricetulus griseus	73-78
8494607-7	1993	In the absence of the pro sequence, N-glycoylation at Asn-75 was essential for the secretion of active renin protein from all three cell types.	Asparagine	54-57	renin	Homo sapiens	103-108
8494607-8	1993	The mutation at Asn-75 caused a more dramatic reduction in renin secretion than the mutation at Asn-5.	Asparagine	16-19	renin	Homo sapiens	59-64
8483933-3	1993	The primary mechanism of recognition and binding is the insertion of the solvent-accessible Phe-43 of CD4 into a gp120 solvent-accessible acceptor pit formed by Trp-427, Tyr-435, and the high-mannose oligosaccharide N-linked to Asn-230.	Asparagine	228-231	CD4 molecule	Homo sapiens	102-105
8483933-3	1993	The primary mechanism of recognition and binding is the insertion of the solvent-accessible Phe-43 of CD4 into a gp120 solvent-accessible acceptor pit formed by Trp-427, Tyr-435, and the high-mannose oligosaccharide N-linked to Asn-230.	Asparagine	228-231	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	113-118
8495193-7	1993	Variants with a histidine residue at position 1106 showed C4B-like binding properties, and those with aspartic acid, alanine, or asparagine at the same position were C4A-like.	Asparagine	129-139	complement C4A (Rodgers blood group)	Homo sapiens	166-169
7681075-2	1993	We have recently demonstrated that the interaction of CD2 with CD58 is dynamic: TCR stimulation or treatment with the phorbol ester PMA rapidly up-regulates CD2 ligand avidity, and this regulation requires the carboxyl-terminal asparagine residue of the CD2 cytoplasmic domain.	Asparagine	228-238	CD2 molecule	Homo sapiens	54-57
7681075-2	1993	We have recently demonstrated that the interaction of CD2 with CD58 is dynamic: TCR stimulation or treatment with the phorbol ester PMA rapidly up-regulates CD2 ligand avidity, and this regulation requires the carboxyl-terminal asparagine residue of the CD2 cytoplasmic domain.	Asparagine	228-238	CD58 molecule	Homo sapiens	63-67
7681075-2	1993	We have recently demonstrated that the interaction of CD2 with CD58 is dynamic: TCR stimulation or treatment with the phorbol ester PMA rapidly up-regulates CD2 ligand avidity, and this regulation requires the carboxyl-terminal asparagine residue of the CD2 cytoplasmic domain.	Asparagine	228-238	CD2 molecule	Homo sapiens	157-160
7681075-2	1993	We have recently demonstrated that the interaction of CD2 with CD58 is dynamic: TCR stimulation or treatment with the phorbol ester PMA rapidly up-regulates CD2 ligand avidity, and this regulation requires the carboxyl-terminal asparagine residue of the CD2 cytoplasmic domain.	Asparagine	228-238	CD2 molecule	Homo sapiens	157-160
7681075-6	1993	Cell lines expressing single amino acid substitutions of the carboxyl-terminal asparagine of CD2 are incapable of avidity regulation by TCR signaling, PMA treatment, or elevation of intracellular cAMP levels, demonstrating that each of these stimuli utilizes a common structural element for regulating CD2 avidity.	Asparagine	79-89	CD2 molecule	Homo sapiens	93-96
7681075-6	1993	Cell lines expressing single amino acid substitutions of the carboxyl-terminal asparagine of CD2 are incapable of avidity regulation by TCR signaling, PMA treatment, or elevation of intracellular cAMP levels, demonstrating that each of these stimuli utilizes a common structural element for regulating CD2 avidity.	Asparagine	79-89	CD2 molecule	Homo sapiens	302-305
8448120-5	1993	The lowest potency was displayed by [B12 Asn]insulin, in which the hydrophobic B12 Val residue was replaced by the hydrophilic Asn residue.	Asparagine	41-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
8448120-5	1993	The lowest potency was displayed by [B12 Asn]insulin, in which the hydrophobic B12 Val residue was replaced by the hydrophilic Asn residue.	Asparagine	41-44	insulin	Homo sapiens	45-52
8448120-5	1993	The lowest potency was displayed by [B12 Asn]insulin, in which the hydrophobic B12 Val residue was replaced by the hydrophilic Asn residue.	Asparagine	41-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	79-82
8448120-5	1993	The lowest potency was displayed by [B12 Asn]insulin, in which the hydrophobic B12 Val residue was replaced by the hydrophilic Asn residue.	Asparagine	127-130	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
8448120-5	1993	The lowest potency was displayed by [B12 Asn]insulin, in which the hydrophobic B12 Val residue was replaced by the hydrophilic Asn residue.	Asparagine	127-130	insulin	Homo sapiens	45-52
8383676-5	1993	Analysis of the hydroxylamine-dependent cleavage of ubiquitin-Cdc34 conjugates at the single Asn-Gly sequence in Cdc34 placed the major ubiquitin linkage site within the C-terminal 215-295 residues of Cdc34.	Asparagine	93-96	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	62-67
8425897-10	1993	Although encoded by a single gene and mRNA in the rat, the majority of spermatozoal CE9 is of smaller apparent molecular mass than its hepatocytic counterpart due to the under-utilization of sites for asparagine-linked glycosylation.	Asparagine	201-211	basigin (Ok blood group)	Rattus norvegicus	84-87
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Asparagine	299-302	cytochrome c	Alligator mississippiensis	85-97
8384830-7	1993	The presence of Pro and Asn residues at positions 89 and 104, respectively, are unique to alligator cytochrome c.	Asparagine	24-27	cytochrome c	Alligator mississippiensis	100-112
8445027-6	1993	A single nucleotide substitution causing an amino acid substitution in the amino terminal domain of the GR (asparagine to serine, codon 363) was also discovered in exon 2 of the other allele (G1220) in the proband, in one of her affected brothers and in her unaffected sister.	Asparagine	108-118	nuclear receptor subfamily 3 group C member 1	Homo sapiens	104-106
7680577-5	1993	Cys-949, being one constituent of the internal thiol ester site of members of the family of proteins related to alpha 2-macroglobulin, is an Asn-residue in hen egg-white ovostatin, but the other constituent, Gln-952, is preserved.	Asparagine	141-144	alpha-2-macroglobulin	Homo sapiens	112-133
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Asparagine	217-220	cytochrome c	Alligator mississippiensis	85-97
8383491-2	1993	The mutation leads to the expression of mutant Asn-187 gelsolin and the accumulation of amyloid in tissues.	Asparagine	47-50	gelsolin	Homo sapiens	55-63
8429005-2	1993	We have employed site-directed mutagenesis to dissect one of the proposed heparin binding domains of avian LPL, which contains the sequence Arg-Lys-Asn-Arg (amino acids 281-284).	Asparagine	148-151	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	107-110
8452235-1	1993	Recent experimental work on the mechanism of action of glycosylasparaginase suggests that the enzyme specifically reacts toward the L-asparagine or L-aspartic acid moiety of its substrates.	Asparagine	132-144	aspartylglucosaminidase	Homo sapiens	55-75
8432860-7	1993	Net negative balances of alanine, methionine, glycine, threonine and asparagine (typical substrates for system A amino acid transport) also were decreased by insulin, whereas serine (another substrate for system A transport) shifted from a zero balance to net uptake.	Asparagine	69-79	insulin	Homo sapiens	158-165
8420926-8	1993	However, if the consensus sequence for N-linked glycosylation at Asn-173 is altered by substitution of Thr-175 with Ala (instead of Asn-173 to Gln), the resulting receptor binds hCG with high affinity although it is still impaired in its ability to be expressed at the plasma membrane.	Asparagine	65-68	hypertrichosis 2 (generalised, congenital)	Homo sapiens	178-181
8459774-5	1993	A single amino acid change of asparagine (N) to aspartate (D) at position 54, adjacent to the site of VirG phosphorylation, aspartate 52, resulted in this constitutive phenotype.	Asparagine	30-40	two-component response regulator VirG	Agrobacterium tumefaciens	102-106
8439991-0	1993	Independent actions of asparagine and high levels of free Ca2+ in the induction of ornithine decarboxylase.	Asparagine	23-33	ornithine decarboxylase 1	Rattus norvegicus	83-106
8419363-0	1993	Glycosylation of human corticosteroid-binding globulin at aspargine 238 is necessary for steroid binding.	Asparagine	58-67	serpin family A member 6	Homo sapiens	23-54
7678100-6	1993	MAb SH1, which recognized Asn at position 4 and Tyr at position 5 from the N terminus was 100 times more potent in neutralizing the bioactivity of STh in the suckling mouse assay than was MAb 11C, which recognized Thr at position 16 and Tyr at position 19 from the N terminus of the STh molecule.	Asparagine	26-29	sperm hammerhead 1	Mus musculus	4-7
8416910-6	1993	Expression of GLN1 and GDH2 exhibited parallel responses to the provision of asparagine and glutamine as nitrogen sources but did not follow the regulatory responses noted above for the nitrogen catabolic genes such as DAL5.	Asparagine	77-87	glutamate--ammonia ligase	Saccharomyces cerevisiae S288C	14-18
8416910-6	1993	Expression of GLN1 and GDH2 exhibited parallel responses to the provision of asparagine and glutamine as nitrogen sources but did not follow the regulatory responses noted above for the nitrogen catabolic genes such as DAL5.	Asparagine	77-87	glutamate dehydrogenase (NAD(+))	Saccharomyces cerevisiae S288C	23-27
8481665-1	1993	L-asparaginase is an enzyme which hydrolyses asparagine.	Asparagine	45-55	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
8093355-7	1993	This sequence is Gly-Xa-Xa-Xa-Gly, represented by Gly505-Ser-Asn-Tyr-Gly509 in the case of ANF-RGC ARM and by Gly499-Ser-Ser-Tyr-Gly503 in the CNP receptor guanylate cyclase ARM.	Asparagine	61-64	natriuretic peptide A	Homo sapiens	91-94
8093355-7	1993	This sequence is Gly-Xa-Xa-Xa-Gly, represented by Gly505-Ser-Asn-Tyr-Gly509 in the case of ANF-RGC ARM and by Gly499-Ser-Ser-Tyr-Gly503 in the CNP receptor guanylate cyclase ARM.	Asparagine	61-64	natriuretic peptide C	Homo sapiens	143-146
8435291-3	1993	Gelsolin, with its asparagine 187 mutation, was found to cause amyloidosis beyond the borders of Finland, where it has been extensively evaluated.	Asparagine	19-29	gelsolin	Mus musculus	0-8
8270114-16	1993	Whether different conformers of or Asn-linked CHOs attached to PrPSc are produced in specific neurons and are responsible for the properties of distinct prion isolates is unknown.	Asparagine	35-38	prion protein	Mus musculus	63-68
8445342-4	1993	DNA sequence analysis of the proband"s LCAT gene identified a C to A substitution, converting tyr83 to a stop codon, and a T to A transition, replacing tyr156 by asn.	Asparagine	162-165	lecithin-cholesterol acyltransferase	Homo sapiens	39-43
8380225-0	1993	The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.	Asparagine	110-113	SDC25	Saccharomyces cerevisiae S288C	29-34
8380225-0	1993	The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.	Asparagine	110-113	Harvey rat sarcoma virus oncogene	Mus musculus	103-109
8439991-2	1993	In order to clarify the relationship between Ca2+ and amino acids, we studied the induction of ODC by asparagine under three different Ca2+ states in H-35 rat hepatoma cells.	Asparagine	102-112	ornithine decarboxylase 1	Rattus norvegicus	95-98
8380225-4	1993	Transcription from the polyomavirus thymidine kinase gene (Py tk) promoter is strongly inhibited by the expression of Ha-Ras Asn-17 in NIH 3T3 cells.	Asparagine	125-128	Harvey rat sarcoma virus oncogene	Mus musculus	118-124
8380225-6	1993	On the other hand, transactivation of the Ras-responsive element of the Py tk promoter induced by SDC25 C domain is lost upon coexpression of increasing amounts of Ha-Ras Asn-17.	Asparagine	171-174	SDC25	Saccharomyces cerevisiae S288C	98-103
8439991-3	1993	First, in normal cells, extracellular Ca2+ above 0.1 mM and 10 mM asparagine separately stimulated ODC activity and their effects were approximately additive.	Asparagine	66-76	ornithine decarboxylase 1	Rattus norvegicus	99-102
8380225-6	1993	On the other hand, transactivation of the Ras-responsive element of the Py tk promoter induced by SDC25 C domain is lost upon coexpression of increasing amounts of Ha-Ras Asn-17.	Asparagine	171-174	Harvey rat sarcoma virus oncogene	Mus musculus	164-170
8380225-7	1993	In addition, coexpression of SDC25 C domain overcomes the inhibition of proliferation of NIH 3T3 cells caused by Ha-Ras Asn-17.	Asparagine	120-123	SDC25	Saccharomyces cerevisiae S288C	29-34
8439991-6	1993	Secondly, in cells treated with 0.5 mM EGTA in Ca(2+)-free medium, the asparagine action on ODC induction was blocked but the inhibition could be reversed by the addition of Ca2+ to the medium.	Asparagine	71-81	ornithine decarboxylase 1	Rattus norvegicus	92-95
8380225-7	1993	In addition, coexpression of SDC25 C domain overcomes the inhibition of proliferation of NIH 3T3 cells caused by Ha-Ras Asn-17.	Asparagine	120-123	Harvey rat sarcoma virus oncogene	Mus musculus	113-119
8380225-8	1993	These results are consistent with the idea that the Ha-Ras Asn-17 mutant functions by titrating an upstream activator of cellular Ras proteins.	Asparagine	59-62	Harvey rat sarcoma virus oncogene	Mus musculus	52-58
1448929-6	1992	Since an asparagine residue has been implicated in the active site of papain, we changed the four conserved asparagine residues in the C-terminal half of nsP2 and found that all could be substituted without total loss of activity.	Asparagine	9-19	reticulon 2	Homo sapiens	154-158
8419930-8	1993	A 35% increase of the specific activity and a large reduction of the Km for thiophene-2-acetonitrile (which was used as a standard substrate for the nitrilase) were observed in the Cys-162--&gt;Asn mutant enzyme.	Asparagine	194-197	carbon-nitrogen hydrolase family protein	Alcaligenes faecalis	149-158
1466764-8	1992	These data show that the structural integrity surrounding and perhaps including the Asn-Tyr-Pro-Lys region may be crucial for the biological activity of rIL-1 beta and may be important for the binding of IL-1 to its receptor.	Asparagine	84-87	interleukin 1 beta	Rattus norvegicus	153-163
1448068-1	1992	We have used a dominant inhibitory ras mutant (Ha-ras Asn-17) to investigate the relationship of Ras proteins to hydrolysis of phosphatidylcholine (PC) in the transduction of mitogenic signals.	Asparagine	54-57	Harvey rat sarcoma virus oncogene	Mus musculus	47-53
8093218-1	1993	To examine the role of the glycans of human immunodeficiency virus type 1 transmembrane glycoprotein gp41, conserved glycosylation sites within the env sequence (Asn-621, Asn-630, and Asn-642) were mutated to Gln.	Asparagine	162-165	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	148-151
1493949-3	1992	This was based on the recent finding that the sequence of the binding domain of the platelet membrane receptor to fibrinogen was identified as TDVNGDGRHDL (one-letter amino acid code; Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu), entitled B12.	Asparagine	196-199	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	239-242
1331527-4	1992	One of the cell lines expressed a mutant of hPVR, in which both asparagine residues of the two N-glycosylation sites of the V domain were changed to aspartate (N105D) and serine (N120S), respectively.	Asparagine	64-74	PVR cell adhesion molecule	Homo sapiens	44-48
1448929-6	1992	Since an asparagine residue has been implicated in the active site of papain, we changed the four conserved asparagine residues in the C-terminal half of nsP2 and found that all could be substituted without total loss of activity.	Asparagine	108-118	reticulon 2	Homo sapiens	154-158
1436092-6	1992	Here we show that replacement of a single amino acid in the human receptor (threonine at residue 355) with a corresponding asparagine found in rodent 5-HT1B receptors renders the pharmacology of the receptors essentially identical.	Asparagine	123-133	5-hydroxytryptamine receptor 1B	Homo sapiens	150-156
1445886-6	1992	Coumarin 7-hydroxylation activity is greatly stimulated by cytochrome b5 only when Phe is at position 209, while cytochrome b5 stimulates testosterone hydroxylation activity of P450coh in which Phe, Asn, Ser or Lys substitutes residue 209.	Asparagine	199-202	cytochrome b5 type A (microsomal)	Mus musculus	113-126
1332763-0	1992	Effect of Asp-235--&gt;Asn substitution on the absorption spectrum and hydrogen peroxide reactivity of cytochrome c peroxidase.	Asparagine	23-26	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	103-126
1458828-0	1992	The critical role of asparagine 502 in post-translational alteration of protein 4.1.	Asparagine	21-31	erythrocyte membrane protein band 4.1	Homo sapiens	72-83
1473557-2	1992	With respect to the published Wistar rat estrogen receptor sequence, a single amino acid difference (tryptophan instead of asparagine) was found in the hormone binding site.	Asparagine	123-133	estrogen receptor 1	Rattus norvegicus	41-58
1421410-5	1992	Analysis of carbohydrate composition and treatment with N-glycanase showed that the Asn-linked unit of glycophorin A was not affected.	Asparagine	84-87	glycophorin A (MNS blood group)	Homo sapiens	103-116
1477273-6	1992	Two alternative positions of B25 Phe and A21 Asn observed in cubic insulin at pH 11 are similar to those found in two independent molecules of the 2Zn insulin dimer at pH 6.4.	Asparagine	45-48	insulin	Bos taurus	67-74
1477273-6	1992	Two alternative positions of B25 Phe and A21 Asn observed in cubic insulin at pH 11 are similar to those found in two independent molecules of the 2Zn insulin dimer at pH 6.4.	Asparagine	45-48	insulin	Bos taurus	151-158
1458828-8	1992	Two proteolytic peptides, D7 and D9 derived from canine protein 4.1, both corresponding to the human sequence Thr492-...-Asn (or Asp)502-...-Lys505 showed the same sequence, Thr-Gln-Thr-...-Lys, except that the 11th residue equivalent to the 502nd amino acid was Asn in D7 while it was Asp in D9, indicating that deamidation occurs at the same position in canine protein 4.1 as in humans.	Asparagine	121-124	erythrocyte membrane protein band 4.1	Canis lupus familiaris	56-67
1458828-8	1992	Two proteolytic peptides, D7 and D9 derived from canine protein 4.1, both corresponding to the human sequence Thr492-...-Asn (or Asp)502-...-Lys505 showed the same sequence, Thr-Gln-Thr-...-Lys, except that the 11th residue equivalent to the 502nd amino acid was Asn in D7 while it was Asp in D9, indicating that deamidation occurs at the same position in canine protein 4.1 as in humans.	Asparagine	263-266	erythrocyte membrane protein band 4.1	Canis lupus familiaris	56-67
1458828-10	1992	However, substitution of Ser for Asn at this position was observed in feline protein 4.1.	Asparagine	33-36	erythrocyte membrane protein band 4.1	Canis lupus familiaris	77-88
1390770-3	1992	We constructed human EPO variants that eliminated the three N-glycosylation sites by replacing the asparagines with glutamines singly or in combination.	Asparagine	99-110	erythropoietin	Homo sapiens	21-24
1436517-0	1992	Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70.	Asparagine	109-119	transthyretin	Homo sapiens	85-98
1385442-5	1992	DNA sequence analysis has shown that the amino-terminal regions of NUP49, NUP100, and NUP116 share repeated "GLFG" motifs separated from each other by glutamine, asparagine, serine and threonine rich spacers.	Asparagine	162-172	FG-nucleoporin NUP49	Saccharomyces cerevisiae S288C	67-72
1385442-5	1992	DNA sequence analysis has shown that the amino-terminal regions of NUP49, NUP100, and NUP116 share repeated "GLFG" motifs separated from each other by glutamine, asparagine, serine and threonine rich spacers.	Asparagine	162-172	FG-nucleoporin NUP100	Saccharomyces cerevisiae S288C	74-80
1385442-5	1992	DNA sequence analysis has shown that the amino-terminal regions of NUP49, NUP100, and NUP116 share repeated "GLFG" motifs separated from each other by glutamine, asparagine, serine and threonine rich spacers.	Asparagine	162-172	FG-nucleoporin NUP116	Saccharomyces cerevisiae S288C	86-92
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Asparagine	106-109	insulin receptor	Homo sapiens	88-104
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Asparagine	149-152	albumin	Homo sapiens	12-15
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Asparagine	106-109	insulin	Homo sapiens	88-95
1445390-0	1992	Relationship between Ca2+ and L-asparagine in the induction of ornithine decarboxylase in H-35 rat hepatoma cells.	Asparagine	30-42	ornithine decarboxylase 1	Rattus norvegicus	63-86
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Asparagine	177-180	insulin receptor	Homo sapiens	88-104
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Asparagine	177-180	insulin	Homo sapiens	88-95
1415709-10	1992	Asparagine at 10 mM or 5% dFBS not only stimulated ODC activity and the intracellular putrescine levels but also increased significantly SAMDC activity as well.	Asparagine	0-10	ornithine decarboxylase 1	Rattus norvegicus	51-54
1415709-10	1992	Asparagine at 10 mM or 5% dFBS not only stimulated ODC activity and the intracellular putrescine levels but also increased significantly SAMDC activity as well.	Asparagine	0-10	adenosylmethionine decarboxylase 1	Rattus norvegicus	137-142
1415709-11	1992	ODC activity peaked at 3 h, and the maximum level of SAMDC occurred 3-4 h after exposure to asparagine or serum.	Asparagine	92-102	ornithine decarboxylase 1	Rattus norvegicus	0-3
1415709-11	1992	ODC activity peaked at 3 h, and the maximum level of SAMDC occurred 3-4 h after exposure to asparagine or serum.	Asparagine	92-102	adenosylmethionine decarboxylase 1	Rattus norvegicus	53-58
1415709-12	1992	Treatment with DL-alpha-difluoromethylornithine (DFMO), a specific ODC inhibitor, prevented the increases in both cellular putrescine levels and SAMDC activity in asparagine- and serum-treated cells.	Asparagine	163-173	ornithine decarboxylase 1	Rattus norvegicus	67-70
1415709-12	1992	Treatment with DL-alpha-difluoromethylornithine (DFMO), a specific ODC inhibitor, prevented the increases in both cellular putrescine levels and SAMDC activity in asparagine- and serum-treated cells.	Asparagine	163-173	adenosylmethionine decarboxylase 1	Rattus norvegicus	145-150
1400872-3	1992	Sequence analysis of these exons revealed a point mutation encoding an amino acid substitution (Asp --&gt; Asn) at residue 327 in the SHBG polypeptide, and the same mutation was identified in three siblings who also appear to be homozygous for this trait.	Asparagine	107-110	sex hormone-binding globulin	Cricetulus griseus	134-138
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Asparagine	149-152	albumin	Homo sapiens	32-35
1445390-1	1992	The activity of ornithine decarboxylase (ODC) in H-35 hepatoma cells depleted of Ca2+ by washing with 2 mM EGTA increased 35-fold after incubating for 4 h in a simple salt-glucose solution containing 10 mM L-asparagine and only if Ca2+ was replenished.	Asparagine	206-218	ornithine decarboxylase 1	Rattus norvegicus	16-39
1445390-1	1992	The activity of ornithine decarboxylase (ODC) in H-35 hepatoma cells depleted of Ca2+ by washing with 2 mM EGTA increased 35-fold after incubating for 4 h in a simple salt-glucose solution containing 10 mM L-asparagine and only if Ca2+ was replenished.	Asparagine	206-218	ornithine decarboxylase 1	Rattus norvegicus	41-44
1445390-4	1992	Asparagine prolonged the half-life of induced ODC by 20% whereas Ca2+ reduced it by 32%.	Asparagine	0-10	ornithine decarboxylase 1	Rattus norvegicus	46-49
1445390-5	1992	The observed inductive effects are not accounted for entirely by a direct influence of Ca2+ and asparagine on the turnover of ODC protein.	Asparagine	96-106	ornithine decarboxylase 1	Rattus norvegicus	126-129
1338910-0	1992	Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187.	Asparagine	48-58	gelsolin	Homo sapiens	0-8
1427854-4	1992	A deletion of an asparagine in CGM9 results in loss of a glycosylation site, which is conserved throughout the CEA gene family.	Asparagine	17-27	CEA cell adhesion molecule pseudogene 2	Homo sapiens	31-35
1427854-4	1992	A deletion of an asparagine in CGM9 results in loss of a glycosylation site, which is conserved throughout the CEA gene family.	Asparagine	17-27	CEA cell adhesion molecule 3	Homo sapiens	111-114
1448117-3	1992	The major sites of M-6-P addition are at Asn (82) and Asn (136), the first two sites of glycosylation, for the TGF beta 1 precursor.	Asparagine	41-44	transforming growth factor beta 1	Homo sapiens	111-121
1448117-3	1992	The major sites of M-6-P addition are at Asn (82) and Asn (136), the first two sites of glycosylation, for the TGF beta 1 precursor.	Asparagine	54-57	transforming growth factor beta 1	Homo sapiens	111-121
1448117-6	1992	Substitution of Asn (241) of the TGF beta 2 (414) precursor resulted in an 82% decrease in secreted TGF beta 2 bioactivity.	Asparagine	16-19	transforming growth factor beta 2	Homo sapiens	33-43
1448117-6	1992	Substitution of Asn (241) of the TGF beta 2 (414) precursor resulted in an 82% decrease in secreted TGF beta 2 bioactivity.	Asparagine	16-19	transforming growth factor beta 2	Homo sapiens	100-110
1338910-7	1992	We conclude that substitution of the uncharged Asn or Tyr for the acidic Asp at residue 187 creates a conformation that may be preferentially amyloidogenic for GSN.	Asparagine	47-50	gelsolin	Homo sapiens	160-163
1388166-4	1992	A GalNAc-transferase that recognizes the tripeptide motif Pro-Xaa-Arg/Lys 6-9 residues N-terminal to Asn glycosylation sites accounts for the specific addition of GalNAc to the oligosaccharide acceptor on these glycoproteins, whereas a GalNAc beta 1,4GlcNAc beta 1, 2Man alpha-4-sulfotransferase accounts for the addition of sulfate.	Asparagine	101-104	lymphocyte antigen 9	Homo sapiens	58-77
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Asparagine	91-101	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	18-22
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Asparagine	91-101	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	122-126
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Asparagine	91-101	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	122-126
1380830-0	1992	Importance of asparagine-61 and asparagine-109 to the angiogenic activity of human angiogenin.	Asparagine	14-24	angiogenin	Homo sapiens	83-93
1382314-3	1992	In the NR1 subunit, replacement of this asparagine by a glutamine residue decreases calcium permeability of the channel and slightly reduces magnesium block.	Asparagine	40-50	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	7-10
1380830-0	1992	Importance of asparagine-61 and asparagine-109 to the angiogenic activity of human angiogenin.	Asparagine	32-42	angiogenin	Homo sapiens	83-93
1330568-0	1992	Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor necrosis factor (TNF) receptor.	Asparagine	18-21	tumor necrosis factor	Homo sapiens	87-108
1443548-3	1992	Ovalbumin, the 43-kDa glycoprotein of avian egg white, is known to be heterogeneous in nature with at least nine different carbohydrate structures having been identified on the single Asn residue.	Asparagine	184-187	ovalbumin	Bos taurus	0-9
1520279-6	1992	We show that the extent of glycosylation of individual t-PA molecules is dependent on the state of folding of the polypeptide chain, since the probability of addition of an oligosaccharide side chain at Asn-184 is decreased under conditions that promote the formation of enzymically active molecules.	Asparagine	203-206	plasminogen activator, tissue type	Homo sapiens	55-59
1323278-4	1992	Mouse GPT has two copies of a putative dolichol-recognition sequence that has so far been identified in all eukaryotic enzymes which interact with dolichol, and four consensus sites for asparagine-linked glycosylation.	Asparagine	186-196	glutamic pyruvic transaminase, soluble	Mus musculus	6-9
1358789-6	1992	Three children had inherited a G-to-A transition at codon 415 in exon 12 of the PAH gene, resulting in the substitution of asparagine for aspartate, whereas one child possessed an A-to-G transition at codon 306 in exon 9, causing the replacement of an isoleucine by a valine in the enzyme.	Asparagine	123-133	phenylalanine hydroxylase	Homo sapiens	80-83
1510926-1	1992	The functional role of Asp80, a residue involved in the coordination of the Mg(2+).guanine nucleotide complex in elongation factor Tu (EF-Tu), has been investigated by its substitution with Asn in the isolated N-terminal domain (G domain).	Asparagine	190-193	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	135-140
1330568-0	1992	Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor necrosis factor (TNF) receptor.	Asparagine	18-21	tumor necrosis factor	Homo sapiens	110-113
1330568-4	1992	An Asn/Val sequence close to the transmembrane region in TNF-R55 was indicated as a putative cleavage site for proteolytic processing.	Asparagine	3-6	TNF receptor superfamily member 1A	Homo sapiens	57-64
1330568-8	1992	However, mutations of the cleavage site resulted in a decreased spontaneous and phorbol ester-induced release of soluble receptor (TNF-R55-BP) which was almost abolished when both Asn and Val were mutated.	Asparagine	180-183	TNF receptor superfamily member 1A	Homo sapiens	131-138
1330568-9	1992	Our results clearly demonstrate the importance of an Asn/Val sequence for proteolytic processing of the TNF-R55 into soluble TNF-R55-BP and indicate that phorbol ester-induced downregulation of the TNF-R55 may be dissociated from proteolytic cleavage of the receptor.	Asparagine	53-56	TNF receptor superfamily member 1A	Homo sapiens	104-111
1330568-9	1992	Our results clearly demonstrate the importance of an Asn/Val sequence for proteolytic processing of the TNF-R55 into soluble TNF-R55-BP and indicate that phorbol ester-induced downregulation of the TNF-R55 may be dissociated from proteolytic cleavage of the receptor.	Asparagine	53-56	TNF receptor superfamily member 1A	Homo sapiens	125-132
1330568-9	1992	Our results clearly demonstrate the importance of an Asn/Val sequence for proteolytic processing of the TNF-R55 into soluble TNF-R55-BP and indicate that phorbol ester-induced downregulation of the TNF-R55 may be dissociated from proteolytic cleavage of the receptor.	Asparagine	53-56	TNF receptor superfamily member 1A	Homo sapiens	125-132
1378869-8	1992	KE36-7 bound strongly to the 10-mer peptide-gp46 187-196, and weakly to peptides containing the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu).	Asparagine	146-149	serpin family H member 1	Homo sapiens	96-100
1353888-4	1992	Mutational analysis of the CD2 cytoplasmic domain demonstrates that the carboxyl-terminal asparagine is essential for T-cell receptor-induced changes in CD2 avidity but is not essential for CD2-mediated signaling, establishing that the cytoplasmic portion of CD2 consists of distinct functional domains.	Asparagine	90-100	CD2 molecule	Homo sapiens	27-30
1463791-1	1992	A method to quantify asparagine (Asn), aspartate (Asp) and isoaspartate (isoAsp) residues in small peptides by fast atom bombardment mass spectrometry (FAB-MS) was developed.	Asparagine	21-31	FA complementation group B	Homo sapiens	152-155
1463791-1	1992	A method to quantify asparagine (Asn), aspartate (Asp) and isoaspartate (isoAsp) residues in small peptides by fast atom bombardment mass spectrometry (FAB-MS) was developed.	Asparagine	33-36	FA complementation group B	Homo sapiens	152-155
1463791-5	1992	FAB CID-MS spectra of the Asn tetrapeptide, Thr-Asn-Ser-Tyr, were used to confirm the position of deuteration to the C-terminal residue.	Asparagine	26-29	FA complementation group B	Homo sapiens	0-3
1463791-5	1992	FAB CID-MS spectra of the Asn tetrapeptide, Thr-Asn-Ser-Tyr, were used to confirm the position of deuteration to the C-terminal residue.	Asparagine	48-51	FA complementation group B	Homo sapiens	0-3
1353888-4	1992	Mutational analysis of the CD2 cytoplasmic domain demonstrates that the carboxyl-terminal asparagine is essential for T-cell receptor-induced changes in CD2 avidity but is not essential for CD2-mediated signaling, establishing that the cytoplasmic portion of CD2 consists of distinct functional domains.	Asparagine	90-100	CD2 molecule	Homo sapiens	153-156
1353888-4	1992	Mutational analysis of the CD2 cytoplasmic domain demonstrates that the carboxyl-terminal asparagine is essential for T-cell receptor-induced changes in CD2 avidity but is not essential for CD2-mediated signaling, establishing that the cytoplasmic portion of CD2 consists of distinct functional domains.	Asparagine	90-100	CD2 molecule	Homo sapiens	153-156
1353888-4	1992	Mutational analysis of the CD2 cytoplasmic domain demonstrates that the carboxyl-terminal asparagine is essential for T-cell receptor-induced changes in CD2 avidity but is not essential for CD2-mediated signaling, establishing that the cytoplasmic portion of CD2 consists of distinct functional domains.	Asparagine	90-100	CD2 molecule	Homo sapiens	153-156
1637300-3	1992	We have isolated a cDNA clone of hexokinase from a lambda gt11 human placenta library comprising 2658 bp, containing a single open reading frame of 1893 nucleotides, which encodes a truncate form of hexokinase starting from asparagine-287 to the terminal serine-917.	Asparagine	224-234	hexokinase 1	Homo sapiens	33-43
1377680-8	1992	Approximately half of the mevalonic aciduria cDNA clones encoding mevalonate kinase contained a single base substitution (A to C) in the coding region at nucleotide 902 that changed an asparagine residue to a threonine residue.	Asparagine	185-195	mevalonate kinase	Homo sapiens	66-83
1637301-3	1992	In order to release mature recombinant-derived hIGF-I (rhIGF-I), the fusion protein is treated with hydroxylamine, which cleaves a susceptible Asn-Gly bond that has been engineered into the fusion protein gene.	Asparagine	143-146	insulin like growth factor 1	Homo sapiens	47-53
1378441-1	1992	Aspartyl (asparaginyl) beta-hydroxylase which specifically hydroxylates 1 Asp or Asn residue in certain epidermal growth factor-like domains of a number of proteins, has been previously purified to apparent homogeneity from detergent-solubilized bovine liver microsomes (Wang, Q., VanDusen, W. J., Petroski, C. J., Garsky, V. M., Stern, A. M., and Friedman, P. A.	Asparagine	81-84	aspartate beta-hydroxylase	Bos taurus	0-39
1637300-3	1992	We have isolated a cDNA clone of hexokinase from a lambda gt11 human placenta library comprising 2658 bp, containing a single open reading frame of 1893 nucleotides, which encodes a truncate form of hexokinase starting from asparagine-287 to the terminal serine-917.	Asparagine	224-234	hexokinase 1	Homo sapiens	199-209
1637312-0	1992	Separation and characterization of the two Asn-linked glycosylation sites of chicken serum riboflavin-binding protein.	Asparagine	43-46	riboflavin binding protein	Gallus gallus	91-117
1634621-3	1992	The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen.	Asparagine	30-40	fibrinogen beta chain	Homo sapiens	211-221
1634621-3	1992	The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen.	Asparagine	179-189	fibrinogen beta chain	Homo sapiens	211-221
1508225-6	1992	Substitution of the Asn residue in either consensus sequence for Asn-linked glycosylation with an Ile residue resulted in increased mobility of the immunoreactive ABP species.	Asparagine	20-23	sex hormone binding globulin	Rattus norvegicus	163-166
1522554-2	1992	L-asparaginase is an enzyme that inhibits protein synthesis by the depletion of sources of L-asparagine, which is necessary for transformed lymphoid cells to proliferate.	Asparagine	91-103	asparaginase and isoaspartyl peptidase 1	Canis lupus familiaris	0-14
1355416-0	1992	Amyloidogenic and non-amyloidogenic transthyretin Asn 90 variants.	Asparagine	50-53	transthyretin	Homo sapiens	36-49
1355416-5	1992	Comparative isoelectric focusing between the variants and TTR Asn 90 produced by recombinant techniques indicated that the non-pathogenic variant has the electrophoretic behaviour expected for the mutation.	Asparagine	62-65	transthyretin	Homo sapiens	58-61
1508225-6	1992	Substitution of the Asn residue in either consensus sequence for Asn-linked glycosylation with an Ile residue resulted in increased mobility of the immunoreactive ABP species.	Asparagine	65-68	sex hormone binding globulin	Rattus norvegicus	163-166
1508225-9	1992	These results demonstrate that the mol wt heterogeneity of ABP is due to differential Asn-linked glycosylation of both potential sites.	Asparagine	86-89	sex hormone binding globulin	Rattus norvegicus	59-62
1620108-3	1992	GTR1 encodes a protein consisting of 310 amino acid residues containing, in its N-terminal region, the characteristic tripartite consensus elements for binding GTP conserved in GTP-binding proteins, except for histidine in place of a widely conserved aspargine residue in element III.	Asparagine	251-260	Rag GTPase GTR1	Saccharomyces cerevisiae S288C	0-4
1601863-2	1992	The structural and functional roles of the single asparagine (N)-linked oligosaccharide chain of Band 3 (AE1), the anion transport protein of the human erythrocyte membrane, were examined.	Asparagine	50-60	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	105-108
1325687-8	1992	If glutamate 387 of rat brain sodium channel II is the ion-pairing site for the guanidinium group, then the carbonyl oxygen of asparagine 388 is the hydrogen acceptor for the C-9 and C-10 -OHs.	Asparagine	127-137	complement C9	Rattus norvegicus	175-178
1303173-1	1992	The high prevalence of glucose 6-phosphate dehydrogenase (G6PD) deficiency in African populations is due almost entirely to the enzyme variant A-, which differs from the wild-type G6PD B by two amino acid replacements, 68 Val--&gt;Met and 126 Asn--&gt;Asp.	Asparagine	243-246	glucose-6-phosphate dehydrogenase	Homo sapiens	58-62
1303173-2	1992	The non-deficient polymorphic variant G6PD A contains only the mutation 126 Asn--&gt;Asp.	Asparagine	76-79	glucose-6-phosphate dehydrogenase	Homo sapiens	38-42
1414488-4	1992	The peptide (osteopontin-k) had a potential glycosylation site (Asn-X-Ser/Thr), a GRGDS receptor binding region, a high level of asparagine residues, and a high abundance of acid amino acids characteristic of osteopontin-like cell adhesion molecules.	Asparagine	129-139	secreted phosphoprotein 1	Homo sapiens	13-24
1533159-2	1992	(1990) Biochemistry 29, 3570-3578], recombinant C1s expressed by insect cells after infection with recombinant baculovirus entirely lacks posttranslational modification at asparagine 134.	Asparagine	172-182	complement C1s	Homo sapiens	48-51
1594597-4	1992	In patient ARC-21, a methionine-to-threonine substitution at position 1772 in the factor VIII light chain creates a potential new N-glycosylation site at asparagine-1770.	Asparagine	154-164	actin related protein 2/3 complex subunit 3	Homo sapiens	11-17
1304366-6	1992	Reaction of enzyme in the presence of substrate (showing no activity loss) yielded a single peptide, Asn-Ile-X1-Lys, where X1 corresponds to Cys164 of the known amino acid sequence of muscle pyruvate kinase.	Asparagine	101-104	pyruvate kinase PKLR	Oryctolagus cuniculus	191-206
1428526-0	1992	Degradation of aspartic acid and asparagine residues in human growth hormone-releasing factor.	Asparagine	33-43	growth hormone releasing hormone	Homo sapiens	62-93
1626428-1	1992	Proteinase B precursors are modified by an N-linked carbohydrate side chain at Asn 314.	Asparagine	79-82	proteinase B	Saccharomyces cerevisiae S288C	0-12
1575731-1	1992	Peptide T (H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH), a fragment of HIV gp120, has been reported to inhibit binding of the virus to the CD4 receptor.	Asparagine	33-36	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
1575731-1	1992	Peptide T (H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH), a fragment of HIV gp120, has been reported to inhibit binding of the virus to the CD4 receptor.	Asparagine	33-36	CD4 molecule	Homo sapiens	132-144
1551892-2	1992	Human glycoasparaginase (N4-(beta-N-acetyl-D-glucosaminyl)-L-asparaginase, EC 3.5.1.26) hydrolyzes a series of compounds that contain L-asparagine residue with free alpha-amino and alpha-carboxyl groups.	Asparagine	134-146	asparaginase and isoaspartyl peptidase 1	Homo sapiens	59-73
1551904-0	1992	Mechanism of regulation of ornithine decarboxylase gene expression by asparagine in a variant mouse neuroblastoma cell line.	Asparagine	70-80	ornithine decarboxylase, structural 1	Mus musculus	27-50
1551904-2	1992	When DF-40 cells were maintained in a simple salt glucose medium (e.g. Earle"s blanced salt solution), L-asparagine alone was sufficient to induce a maximal increase in ODC activity.	Asparagine	103-115	ornithine decarboxylase, structural 1	Mus musculus	169-172
1551904-4	1992	Northern blot analysis indicated that asparagine caused a 12-15-fold increase in ODC mRNA.	Asparagine	38-48	ornithine decarboxylase, structural 1	Mus musculus	81-84
1551904-5	1992	The half-life of ODC mRNA induced by asparagine in DF-40 cells changed from more than 8 h to about 25 min upon removal of asparagine from the culture in the presence of actinomycin D.	Asparagine	37-47	ornithine decarboxylase, structural 1	Mus musculus	17-20
1551904-5	1992	The half-life of ODC mRNA induced by asparagine in DF-40 cells changed from more than 8 h to about 25 min upon removal of asparagine from the culture in the presence of actinomycin D.	Asparagine	122-132	ornithine decarboxylase, structural 1	Mus musculus	17-20
1551904-7	1992	Pulse labeling of cells for 15 min with [35S]methionine showed a 90-140-fold increase in the synthesis of ODC protein after 4-8 h of incubation with asparagine.	Asparagine	149-159	ornithine decarboxylase, structural 1	Mus musculus	106-109
1551904-8	1992	The removal of asparagine from the medium resulted in a rapid loss of ODC protein with a half-life as short as 12 min.	Asparagine	15-25	ornithine decarboxylase, structural 1	Mus musculus	70-73
1551904-9	1992	The presence of asparagine increased the half-life of ODC protein by 3-5-fold when measured in the presence of cycloheximide.	Asparagine	16-26	ornithine decarboxylase, structural 1	Mus musculus	54-57
1551904-10	1992	Taken together, our data show that asparagine induced ODC gene expression in DF-40 cells, primarily by post-transcriptional stabilization of ODC mRNA.	Asparagine	35-45	ornithine decarboxylase, structural 1	Mus musculus	54-57
1551904-10	1992	Taken together, our data show that asparagine induced ODC gene expression in DF-40 cells, primarily by post-transcriptional stabilization of ODC mRNA.	Asparagine	35-45	ornithine decarboxylase, structural 1	Mus musculus	141-144
1551904-11	1992	In addition, asparagine specifically stimulated the synthesis and suppressed the degradation of ODC protein.	Asparagine	13-23	ornithine decarboxylase, structural 1	Mus musculus	96-99
1551909-4	1992	In addition, complex formation with C1s was detected for P1-Asn and P1-His.	Asparagine	60-63	complement C1s	Homo sapiens	36-39
1525954-0	1992	Deamidation at asparagine-88 in recombinant human interleukin 2.	Asparagine	15-25	interleukin 2	Homo sapiens	50-63
1525954-1	1992	Reversed-phase high-performance liquid chromatography (RP-HPLC) and protein-chemical analysis revealed that only Asn88 in recombinant human interleukin 2 (rIL-2) is liable to be deamidated during a long period of storage in aqueous solutions (pH 5.0) at 25 degrees C, even though there are eight asparagine and six glutamine residues.	Asparagine	296-306	interleukin 2	Homo sapiens	140-153
1525954-1	1992	Reversed-phase high-performance liquid chromatography (RP-HPLC) and protein-chemical analysis revealed that only Asn88 in recombinant human interleukin 2 (rIL-2) is liable to be deamidated during a long period of storage in aqueous solutions (pH 5.0) at 25 degrees C, even though there are eight asparagine and six glutamine residues.	Asparagine	296-306	interleukin 2	Rattus norvegicus	155-160
1344712-0	1992	Alpha 1-6(alpha 1-3)-difucosylation of the asparagine-bound N-acetylglucosamine in honeybee venom phospholipase A2.	Asparagine	43-53	phospholipase A2	Apis mellifera	98-114
1554693-5	1992	Six GCAP mutants that lack one or both glycosylation sites were constructed by substituting either Asn-122 or Asn-249 with an Asp residue or either Thr-124 or Thr-251 with an Ala residue.	Asparagine	99-102	alkaline phosphatase, germ cell	Homo sapiens	4-8
1373885-6	1992	MAb and polyclonal antibodies specific for B blood group antigen failed to react with SP-A from this patient or from patients who were in blood group B. Reactivity of anti-blood group MAb was lost after treatment of SP-A with endoglycosidase-F, demonstrating its reactivity with an epitope dependent on the asparagine-linked oligosaccharide at asparagine 187.	Asparagine	307-317	surfactant protein A1	Homo sapiens	216-220
1549559-3	1992	By genetically selecting for derivatives of yeast GCN4 that activate transcription from promoters containing mutant binding sites, we isolate an altered-specificity mutant in which the invariant asparagine in the basic region of bZIP proteins (Asn-235) has been changed to tryptophan.	Asparagine	195-205	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	50-54
1372009-1	1992	We have shown previously that a deletion mutant of human heparin-binding growth factor (HBGF)-1, HBGF-1U, lacking the sequence Asn-Tyr-Lys-Lys-Pro-Lys-Leu is capable of initiating c-fos mRNA expression and polypeptide phosphorylation on tyrosine residues at concentrations that do not induce either DNA synthesis or cell proliferation (1).	Asparagine	127-130	fibroblast growth factor 1	Homo sapiens	57-95
1312393-3	1992	We report that in PC12 cells, expression of a dominant inhibitory mutant of ras, c-Ha-ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the erk-encoded family of MAP kinases, the 85-92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1.	Asparagine	90-93	Eph receptor B1	Rattus norvegicus	170-173
1312393-3	1992	We report that in PC12 cells, expression of a dominant inhibitory mutant of ras, c-Ha-ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the erk-encoded family of MAP kinases, the 85-92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1.	Asparagine	90-93	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	309-314
1549559-3	1992	By genetically selecting for derivatives of yeast GCN4 that activate transcription from promoters containing mutant binding sites, we isolate an altered-specificity mutant in which the invariant asparagine in the basic region of bZIP proteins (Asn-235) has been changed to tryptophan.	Asparagine	244-247	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	50-54
1540404-2	1992	It contains 30-38 potential asparagine-linked glycosylation sites which have been shown to play a role in CD4 binding, virus uptake, and cytopathogenicity.	Asparagine	28-38	CD4 molecule	Homo sapiens	106-109
1531656-3	1992	In addition the des-[Ala-1,Asn-2]- and des-[Ala-1,Asn-2,Lys-3]-fragment 1 derivatives were prepared by limited enzymatic hydrolysis of fragment 1 using cathepsin C and plasmin, respectively.	Asparagine	50-53	plasminogen	Bos taurus	168-175
1540659-3	1992	About half of the abnormal hemoglobin, in addition to the substitution at position beta 81, carries a deamidation of the neighboring asparagine residue, beta 80 (EF4).	Asparagine	133-143	hemoglobin subunit gamma 2	Homo sapiens	18-37
1540659-3	1992	About half of the abnormal hemoglobin, in addition to the substitution at position beta 81, carries a deamidation of the neighboring asparagine residue, beta 80 (EF4).	Asparagine	133-143	GTP binding elongation factor GUF1	Homo sapiens	162-165
1346338-7	1992	In the family with fatal familial insomnia, all 4 affected members and 11 of the 29 unaffected members had a point mutation in PrP codon 178 that results in the substitution of asparagine for aspartic acid and elimination of the Tth111 I restriction site.	Asparagine	177-187	prion protein	Homo sapiens	127-130
1558877-2	1992	The C-terminal and the N-terminal amino acid sequences of the low-molecular-mass protein A were -Asn-Ala-Phe and Ala-Gln-His-Asp-Glu-Ala-Gln-, respectively.	Asparagine	97-100	G protein-coupled receptor 162	Gallus gallus	81-90
1730712-9	1992	Drosophila acetylcholinesterase exhibits four effective sites of asparagine-linked glycosylation in positions 126, 174, 331, and 531.	Asparagine	65-75	Acetylcholine esterase	Drosophila melanogaster	11-31
18647693-2	1992	The eukaryotic PCMT methyl esterifies peptides and proteins containing altered aspartyl residues, such as D-aspartyls and L-isoaspartyls, which can arise from the age-dependent deamidation of labile Asn residues.	Asparagine	199-202	isoprenylcysteine carboxyl methyltransferase	Homo sapiens	15-19
1733280-2	1992	The nucleotide sequence of the composite SP-B cDNAs and cloned genomic SP-B DNA predicted a primary translation product of 377 amino acids (molecular mass = 41.7 kDa) that contained a single asparagine linked glycosylation site.	Asparagine	191-201	surfactant associated protein B	Mus musculus	41-45
1370297-2	1992	The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes.	Asparagine	92-95	zona pellucida glycoprotein 3	Mus musculus	156-159
1742729-0	1991	Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor.	Asparagine	21-33	asparaginase and isoaspartyl peptidase 1	Homo sapiens	53-67
1760844-1	1991	Peptides corresponding to the proposed coated pit internalization signal of the native low density lipoprotein receptor, NPVY, take up in aqueous solution a reverse-turn conformation with the Asn in position i and the Tyr in position i + 3.	Asparagine	192-195	low density lipoprotein receptor	Homo sapiens	87-119
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-52
1761560-6	1991	These observations strongly suggest that 1) N-glycosylation of GLUT1 glucose transporter is only on Asn 45 and 2) N-glycosylation plays an important role in maintaining a structure of glucose transporter with high affinity for glucose, thus, with high transport activity.	Asparagine	100-103	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	63-68
1742729-0	1991	Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor.	Asparagine	21-33	asparaginase and isoaspartyl peptidase 1	Homo sapiens	96-110
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-1	1991	The antileukemic activity of L-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum L-asparagine (Asn).	Asparagine	167-179	asparaginase and isoaspartyl peptidase 1	Homo sapiens	29-43
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-13	1991	Thus, for accurate measurements of the duration and degree of Asn depletion by ASNase, an ASNase inhibitor such as ASA or DONV should be present in the blood collection system.	Asparagine	62-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	79-85
1742729-1	1991	The antileukemic activity of L-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum L-asparagine (Asn).	Asparagine	167-179	asparaginase and isoaspartyl peptidase 1	Homo sapiens	45-51
1742729-13	1991	Thus, for accurate measurements of the duration and degree of Asn depletion by ASNase, an ASNase inhibitor such as ASA or DONV should be present in the blood collection system.	Asparagine	62-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	90-96
1742729-1	1991	The antileukemic activity of L-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum L-asparagine (Asn).	Asparagine	181-184	asparaginase and isoaspartyl peptidase 1	Homo sapiens	29-43
1742729-1	1991	The antileukemic activity of L-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum L-asparagine (Asn).	Asparagine	181-184	asparaginase and isoaspartyl peptidase 1	Homo sapiens	45-51
1742729-2	1991	In studies of the pharmacological effects of ASNase, investigators have reported prolonged reduction in the serum concentration of Asn after the administration of ASNase.	Asparagine	131-134	asparaginase and isoaspartyl peptidase 1	Homo sapiens	45-51
1742729-2	1991	In studies of the pharmacological effects of ASNase, investigators have reported prolonged reduction in the serum concentration of Asn after the administration of ASNase.	Asparagine	131-134	asparaginase and isoaspartyl peptidase 1	Homo sapiens	163-169
1722316-5	1991	The most common escape mutation was an amino acid change of asparagine (AAT) to aspartic acid (GAT) at position 280; an additional mutation was glycine (GGT) to aspartic acid (GAT) at position 282.	Asparagine	60-70	serpin family A member 1	Homo sapiens	72-75
1742729-3	1991	Such measurements may not be valid because ASNase present in the blood sample may hydrolyze Asn before its determination.	Asparagine	92-95	asparaginase and isoaspartyl peptidase 1	Homo sapiens	43-49
1722316-5	1991	The most common escape mutation was an amino acid change of asparagine (AAT) to aspartic acid (GAT) at position 280; an additional mutation was glycine (GGT) to aspartic acid (GAT) at position 282.	Asparagine	60-70	glycine-N-acyltransferase	Homo sapiens	95-98
1742729-6	1991	Utilizing this assay, we studied the effect of 2 known inhibitors of ASNase in an attempt to improve Asn recovery.	Asparagine	101-104	asparaginase and isoaspartyl peptidase 1	Homo sapiens	69-75
1742729-8	1991	ASA prevented the hydrolysis of exogenous Asn in blood samples drawn from patients after ASNase injection.	Asparagine	42-45	asparaginase and isoaspartyl peptidase 1	Homo sapiens	89-95
1742729-10	1991	Using this method, we found that the Asn level was greater than 90% of a normal level in the presence of 40 mM DONV and 1.0 IU/ml ASNase.	Asparagine	37-40	asparaginase and isoaspartyl peptidase 1	Homo sapiens	130-136
1742729-11	1991	Examination of serum from 4 patients treated with ASNase showed that Asn is detectable 7-19 days sooner when DONV is present in the blood collection system than in its absence.	Asparagine	69-72	asparaginase and isoaspartyl peptidase 1	Homo sapiens	50-56
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	67-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-52
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	67-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	67-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	67-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-52
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-52
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1742729-12	1991	We conclude that: (a) as little as 0.01 IU/ml ASNase can hydrolyze Asn added to blood; (b) continued hydrolysis of Asn by ASNase ex vivo can result in falsely low serum Asn measurements; (c) ASA or DONV present in the collection tubes obviates the problem of continued ASNase activity; and (d) the degree and duration of Asn depletion after ASNase therapy is much less than previously believed.	Asparagine	115-118	asparaginase and isoaspartyl peptidase 1	Homo sapiens	122-128
1952937-0	1991	Translational control mechanism of ornithine decarboxylase by asparagine and putrescine in primary cultured hepatocytes.	Asparagine	62-72	ornithine decarboxylase 1	Homo sapiens	35-58
1952937-1	1991	Asparagine stimulated the translation of ornithine decarboxylase (ODC) mRNA more than 10-fold in cultured hepatocytes which had been pretreated with glucagon in simple salt/glucose medium.	Asparagine	0-10	ornithine decarboxylase 1	Homo sapiens	41-64
1952937-2	1991	Putrescine suppressed the increase in the rate of ODC synthesis caused by asparagine without significant change in the amount of ODC mRNA, suggesting that putrescine inhibited the effect of asparagine at least in part at the level of translation.	Asparagine	74-84	ornithine decarboxylase 1	Homo sapiens	50-53
1952937-2	1991	Putrescine suppressed the increase in the rate of ODC synthesis caused by asparagine without significant change in the amount of ODC mRNA, suggesting that putrescine inhibited the effect of asparagine at least in part at the level of translation.	Asparagine	190-200	ornithine decarboxylase 1	Homo sapiens	50-53
1952937-1	1991	Asparagine stimulated the translation of ornithine decarboxylase (ODC) mRNA more than 10-fold in cultured hepatocytes which had been pretreated with glucagon in simple salt/glucose medium.	Asparagine	0-10	ornithine decarboxylase 1	Homo sapiens	66-69
1952937-6	1991	In asparagine-treated cells, 40% of total ODC mRNA was in the polysomal fraction and formed heavier polysomes, indicating that asparagine stimulated both recruitment of ODC mRNA from the untranslatable pool and the initiation steps of translation.	Asparagine	3-13	ornithine decarboxylase 1	Homo sapiens	42-45
1952937-6	1991	In asparagine-treated cells, 40% of total ODC mRNA was in the polysomal fraction and formed heavier polysomes, indicating that asparagine stimulated both recruitment of ODC mRNA from the untranslatable pool and the initiation steps of translation.	Asparagine	3-13	ornithine decarboxylase 1	Homo sapiens	169-172
1952937-6	1991	In asparagine-treated cells, 40% of total ODC mRNA was in the polysomal fraction and formed heavier polysomes, indicating that asparagine stimulated both recruitment of ODC mRNA from the untranslatable pool and the initiation steps of translation.	Asparagine	127-137	ornithine decarboxylase 1	Homo sapiens	42-45
1952937-6	1991	In asparagine-treated cells, 40% of total ODC mRNA was in the polysomal fraction and formed heavier polysomes, indicating that asparagine stimulated both recruitment of ODC mRNA from the untranslatable pool and the initiation steps of translation.	Asparagine	127-137	ornithine decarboxylase 1	Homo sapiens	169-172
1939204-11	1991	A comparison of the overlapping sequence between these two peptides suggests that this calmodulin binding site is localized in a 7-residue segment, 659Trp-Glu-Lys-Gly-Asn-Val-Phe665.	Asparagine	167-170	calmodulin 1	Homo sapiens	87-97
1658621-6	1991	This induction could be suppressed by cotransfection of two inhibitory mutant ras genes, H-ras(Asn-17) or H-ras(Leu-61,Ser-186).	Asparagine	95-98	Harvey rat sarcoma virus oncogene	Mus musculus	89-94
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	Asparagine	30-33	interleukin 1 beta	Homo sapiens	19-28
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	Asparagine	30-33	interleukin 1 beta	Homo sapiens	161-170
1668306-6	1991	This review will examine current hypotheses dealing with GPT and its role in the committed step of asparagine-linked glycosylation.	Asparagine	99-109	glutamic--pyruvic transaminase	Homo sapiens	57-60
1657158-1	1991	Twelve amino acid substitutions of varying size and hydrophobicity were constructed at Val 143 in human carbonic anhydrase II (including Gly, Ser, Cys, Asn, Asp, Leu, Ile, His, Phe and Tyr) to examine the catalytic roles of the hydrophobic pocket in the active site of this enzyme.	Asparagine	152-155	carbonic anhydrase 2	Homo sapiens	104-125
1657965-11	1991	The endoglycosidase F effect and the lack of endoglycosidase H action show that the myometrial oxytocin receptor is highly glycosylated with asparagine-linked complex oligosaccharide chains.	Asparagine	141-151	oxytocin receptor	Cavia porcellus	95-112
1783599-1	1991	The asparagine-linked sugar chains of recombinant human interleukin 5 produced by Chinese hamster ovary cells were released quantitatively as oligosaccharides by hydrazinolysis.	Asparagine	4-14	interleukin 5	Homo sapiens	56-69
1717587-5	1991	Using synthetic peptides, we mapped one of the epitopes recognized by such clones to the sequence 292-300 (NESVAINCT), which contains two asparagines that are glycosylated in the native gp120.	Asparagine	138-149	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	186-191
1657925-2	1991	Codons for asparagine at N-glycosylation sites in genomic human Epo DNA were replaced with those for glutamine.	Asparagine	11-21	erythropoietin	Homo sapiens	64-67
1939089-4	1991	MMCP-5 possesses a unique Asn residue in the substrate binding cleft at residue 176 and is highly basically charged.	Asparagine	26-29	chymase 1, mast cell	Mus musculus	0-6
1918053-7	1991	These midchain reversals include the lysine and asparagine residues proposed to be involved in heparin binding and N-glycosylation, respectively, to laminin peptide F-9.	Asparagine	48-58	coagulation factor IX	Homo sapiens	165-168
1716854-6	1991	This base substitution predicted the replacement of a positively charged lysine by a neutral asparagine (K59N), an amino acid change consistent with the more electronegative charge of the ALAD-2 subunit.	Asparagine	93-103	aminolevulinate dehydratase	Homo sapiens	188-192
1918071-8	1991	We now demonstrate that PDI in the lumen of microsomes is more efficiently labeled by peptides containing photoreactive-Asn-Xaa-Ser/Thr- sequences than by nonacceptor site sequences because the former become glycosylated.	Asparagine	120-123	prolyl 4-hydroxylase subunit beta	Homo sapiens	24-27
1923818-5	1991	The two predicted GAL11 proteins show high overall amino acid conservation and an unusual amino acid composition including 18% glutamine, 10% asparagine (S. cerevisiae) or 7% (K. lactis), and 8% proline (K. lactis) or 5% (S. cerevisiae) residues.	Asparagine	142-152	Gal11p	Saccharomyces cerevisiae S288C	18-23
1937055-4	1991	Even in the absence of an Asn-linked glycosylation site, secretion of hEGF using the synthetic prepro-leader was as efficient as that directed by the alpha-factor leader.	Asparagine	26-29	epidermal growth factor	Homo sapiens	70-74
1655808-2	1991	The 22-kD kFGF product contains a single site for asparagine-linked glycosylation and an amino-terminal signal peptide for vectorial synthesis into the endoplasmic reticulum and eventual secretion.	Asparagine	50-60	fibroblast growth factor 4	Homo sapiens	10-14
1937474-7	1991	The sequence of three independent clones originating from the defective P450c21B showed that Ile at position 172 in exon 4 was substituted by Asn.	Asparagine	142-145	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	72-80
1930202-0	1991	Substitution of asparagine for serine-406 of the immunoglobulin mu heavy chain alters glycosylation at asparagine-402.	Asparagine	16-26	immunoglobulin heavy variable 7-3	Mus musculus	49-78
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Asparagine	110-113	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Asparagine	110-113	renin	Homo sapiens	302-307
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Asparagine	224-227	angiotensinogen	Homo sapiens	41-56
1714377-3	1991	In addition to the previously identified c-kit gene product (Kit+), a second normal Kit isoform (KitA+) containing an in-frame insertion, Gly-Asn-Asn-Lys, within the extracellular domain, was detected in murine mast cell cultures and mid-gestation placenta.	Asparagine	142-145	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	84-87
1894645-0	1991	A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.	Asparagine	39-49	transferrin	Homo sapiens	10-21
1894645-3	1991	Site-directed mutagenesis was performed to abolish the three asparagine-linked glycosylation consensus sequences of the human transferrin receptor.	Asparagine	61-71	transferrin	Homo sapiens	126-137
1894645-5	1991	This form of the human transferrin receptor shows reduced transferrin binding, reduced intersubunit bond formation, and reduced cell surface expression, indicating that the transferrin receptor which lacks asparagine-linked glycosylation is not fully functional.	Asparagine	206-216	transferrin	Homo sapiens	23-34
1840592-11	1991	Two highly homologous cDNA sequences were derived, coding for proteins that displayed the typical features of alpha 2M-type proteinase inhibitors: the overall size, the positions of a putative bait region and of the internal thiol ester, and the positional conservation of cysteine residues and putative asparagine-glycosylation sites.	Asparagine	304-314	alpha-2-macroglobulin	Mus musculus	110-118
1684756-8	1991	Molecular genetic studies disclosed a new G-to-A mutation in codon 178 of the PRNP gene (resulting in a substitution of asparagine for aspartic acid) in the DNA of eight family members with CJD but not in any of ten currently healthy first degree relatives of the patients, or 86 controls.	Asparagine	120-130	prion protein	Homo sapiens	78-82
1714377-3	1991	In addition to the previously identified c-kit gene product (Kit+), a second normal Kit isoform (KitA+) containing an in-frame insertion, Gly-Asn-Asn-Lys, within the extracellular domain, was detected in murine mast cell cultures and mid-gestation placenta.	Asparagine	146-149	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	84-87
1651333-6	1991	In order to evaluate the possible functional role of these acidic residues, we employed site-directed mutagenesis to express two mutant GP Ib alpha fragments containing asparagine or glutamine instead of aspartic or glutamic acid, respectively.	Asparagine	169-179	glycoprotein Ib platelet subunit alpha	Homo sapiens	136-147
1820200-1	1991	Glycopeptides representing individual N-glycosylation sites of the heterodimeric glycoprotein hormone human chorionic gonadotrophin (hCG) were obtained from subunits hCG alpha (N-glycosylated at Asn-52 and Asn-78) and hCG beta (N-glycosylated at Asn-13 and Asn-30) by digestion with trypsin and chymotrypsin, respectively.	Asparagine	206-209	chorionic gonadotropin subunit beta 5	Homo sapiens	81-137
1820200-1	1991	Glycopeptides representing individual N-glycosylation sites of the heterodimeric glycoprotein hormone human chorionic gonadotrophin (hCG) were obtained from subunits hCG alpha (N-glycosylated at Asn-52 and Asn-78) and hCG beta (N-glycosylated at Asn-13 and Asn-30) by digestion with trypsin and chymotrypsin, respectively.	Asparagine	206-209	chorionic gonadotropin subunit beta 5	Homo sapiens	81-137
1820200-1	1991	Glycopeptides representing individual N-glycosylation sites of the heterodimeric glycoprotein hormone human chorionic gonadotrophin (hCG) were obtained from subunits hCG alpha (N-glycosylated at Asn-52 and Asn-78) and hCG beta (N-glycosylated at Asn-13 and Asn-30) by digestion with trypsin and chymotrypsin, respectively.	Asparagine	195-198	chorionic gonadotropin subunit beta 5	Homo sapiens	81-137
1820200-1	1991	Glycopeptides representing individual N-glycosylation sites of the heterodimeric glycoprotein hormone human chorionic gonadotrophin (hCG) were obtained from subunits hCG alpha (N-glycosylated at Asn-52 and Asn-78) and hCG beta (N-glycosylated at Asn-13 and Asn-30) by digestion with trypsin and chymotrypsin, respectively.	Asparagine	206-209	chorionic gonadotropin subunit beta 5	Homo sapiens	81-137
1883364-2	1991	To explore the role of the Asn-linked carbohydrate chains on the follistatin molecule in regard to the inhibition of FSH secretion and activin binding ability, site-specific mutations were introduced at either or both of the two potential Asn-linked glycosylation sites of human follistatin with 315 amino acids (hFS-315).	Asparagine	27-30	follistatin	Homo sapiens	65-76
2072167-6	1991	Significant collateral sensitivity to L-asparaginase indicated that ACNU might disturb the asparagine synthetic pathways by its mutagenic action.	Asparagine	91-101	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	38-52
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	plasminogen activator, tissue type	Homo sapiens	172-205
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	plasminogen activator, tissue type	Homo sapiens	207-210
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	plasminogen activator, tissue type	Homo sapiens	259-262
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	serpin family E member 1	Homo sapiens	267-300
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	serpin family E member 1	Homo sapiens	302-307
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Asparagine	73-76	serpin family E member 1	Homo sapiens	323-328
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Asparagine	82-85	serpin family E member 1	Homo sapiens	44-49
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Asparagine	82-85	serpin family E member 1	Homo sapiens	126-131
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Asparagine	82-85	plasminogen activator, tissue type	Homo sapiens	241-244
1867199-4	1991	Sequencing of the amplified cDNAs disclosed at codon 393 of the mature E1 alpha polypeptide a base substitution changing a tyrosine (encoded by TAC) to an asparagine residue (encoded by AAC), which is designated Y393N.	Asparagine	155-165	glycine-N-acyltransferase	Homo sapiens	186-189
1860561-0	1991	Inducement of antibody that mimics insulin action on insulin receptor by insulin autoantibody directed at determinant at asparagine site on human insulin B chain.	Asparagine	121-131	insulin	Homo sapiens	35-42
1860561-0	1991	Inducement of antibody that mimics insulin action on insulin receptor by insulin autoantibody directed at determinant at asparagine site on human insulin B chain.	Asparagine	121-131	insulin receptor	Homo sapiens	53-69
1860561-0	1991	Inducement of antibody that mimics insulin action on insulin receptor by insulin autoantibody directed at determinant at asparagine site on human insulin B chain.	Asparagine	121-131	insulin	Homo sapiens	53-60
1860561-2	1991	with insulin autoimmune syndrome is directed at a determinant at the asparagine site on the human insulin B chain.	Asparagine	69-79	insulin	Homo sapiens	5-12
2071611-12	1991	This deletion codes for amino acids Asn-319 and Asp-320 in the normal fibrinogen gamma-chain.	Asparagine	36-39	fibrinogen gamma chain	Homo sapiens	70-92
2071611-13	1991	The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen.	Asparagine	23-26	fibrinogen beta chain	Homo sapiens	294-304
1719383-10	1991	Human IGFBP-6 possesses a single Asn-linked glycosylation site near the carboxyl-terminal, whereas no potential Asn-linked glycosylation sites are present in the rat sequence.	Asparagine	33-36	insulin like growth factor binding protein 6	Homo sapiens	6-13
1711072-10	1991	B27-HS now reveals that Lys at position 70 is specific for B27 but Asn at position 97 is not.	Asparagine	67-70	melanocortin 2 receptor accessory protein	Homo sapiens	0-3
1711082-4	1991	An antibody-binding assay using overlapping synthetic oligopeptides showed that LAT-27 bound specifically to 10-mer peptides that contained the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu).	Asparagine	194-197	serpin family H member 1	Homo sapiens	144-148
1711841-3	1991	The amino acid sequence is over 80% homologous with human IGFBP-3 with complete conservation of the 18 cysteine residues and the 3 Asn-linked glycosylation sites.	Asparagine	131-134	insulin like growth factor binding protein 3	Homo sapiens	58-65
1647209-8	1991	Upon treatment with peptide:N-glycosidase F, both bands were shifted to lower molecular masses (20.5 and 18.5 kDa), indicating that CHO cell-derived IFN-omega 1 is glycosylated; Asn-78 was identified as the glycosylation site.	Asparagine	178-181	interferon omega 1	Homo sapiens	149-160
2043765-2	1991	EPO is heavily glycosylated with three asparagine (N)-linked tetraantennary oligosaccharides that may contain N-acetyl-lactosamine repeats and a single serine (O)-linked oligosaccharide.	Asparagine	39-49	erythropoietin	Cricetulus griseus	0-3
1820763-2	1991	It is suggested that each activator is hydrogen-bonded to sulfhydryl groups of cysteine residues and to the carbonyl of an asparagine within the cysteine-rich regions of PKC.	Asparagine	123-133	proline rich transmembrane protein 2	Homo sapiens	170-173
2026597-6	1991	Trypsin digestion of [14C]BrAnd-inactivated 3 alpha-HSD followed by peptide mapping led to the purification of a single radiolabeled peptide (3A1) which gave the following sequence: H2N-Ser-Ile-Gly-Val-Ser-Asn-Phe-Asn-X-Arg-CO2H.	Asparagine	206-209	aldo-keto reductase family 1, member C14	Rattus norvegicus	44-55
1850190-1	1991	A mutation in transthyretin (TTR Asn 90) has been identified in the Portuguese and German populations.	Asparagine	33-36	transthyretin	Homo sapiens	29-32
1645337-5	1991	A systematic analysis revealed that replacement of Asn-115, Arg-154, and Ile-158 of the PDGF B-chain with the corresponding A-chain amino acids led to a dramatic decrease in the affinity for the beta-receptor.	Asparagine	51-54	platelet derived growth factor subunit B	Homo sapiens	88-94
1645337-7	1991	These data thus indicate that Asn-115, Arg-154, and Ile-158 are likely to be part of the active site of the PDGF B-chain.	Asparagine	30-33	platelet derived growth factor subunit B	Homo sapiens	108-114
1917311-1	1991	Two-dimensional HOHAHA and ROESY nuclear magnetic resonance techniques are used to obtain complete proton resonance assignments and to perform a conformational investigation of the neuropeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) in aqueous solution, methanol, and membrane-mimetic [deuterated sodium dodecylsulfate (SDS)] environments.	Asparagine	224-228	neurotensin	Homo sapiens	194-205
1902622-0	1991	Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution.	Asparagine	76-86	glycophorin C (Gerbich blood group)	Homo sapiens	22-35
2023899-8	1991	Protein sequence analysis revealed that one of the PIF peptides was Trp-Cys-Leu-Glu-Ser-Ser-Gln-Cys-Gln-Asp-Leu-Ser-Thr-Glu-Ser-Asn-Leu-Leu- Ala-Cys - Ile-Arg-Ala-Cys-Lys-Pro, identical to residues 27-52 of the N-terminal region of the proopiomelanocortin (POMC) precursor (corresponding to amino acids 1-26 of the 16-kDa fragment).	Asparagine	128-131	proopiomelanocortin	Rattus norvegicus	236-255
2023899-8	1991	Protein sequence analysis revealed that one of the PIF peptides was Trp-Cys-Leu-Glu-Ser-Ser-Gln-Cys-Gln-Asp-Leu-Ser-Thr-Glu-Ser-Asn-Leu-Leu- Ala-Cys - Ile-Arg-Ala-Cys-Lys-Pro, identical to residues 27-52 of the N-terminal region of the proopiomelanocortin (POMC) precursor (corresponding to amino acids 1-26 of the 16-kDa fragment).	Asparagine	128-131	proopiomelanocortin	Rattus norvegicus	257-261
2070783-9	1991	The shortest carbohydrate moiety necessary for Tf staining corresponds to two identical carbohydrate chains of the structure (Asn)-GlcNAc-GlcNAc-beta-Man-(alpha-Man-)-alpha-Man.	Asparagine	126-130	transferrin	Homo sapiens	47-49
2018763-6	1991	The results of this analysis demonstrated that the acidic variant of neuraminidase-treated rCD4 is generated from deamidation at Asn-52.	Asparagine	129-132	neuraminidase 1	Homo sapiens	69-82
2018763-6	1991	The results of this analysis demonstrated that the acidic variant of neuraminidase-treated rCD4 is generated from deamidation at Asn-52.	Asparagine	129-132	Cd4 molecule	Rattus norvegicus	91-95
2018763-7	1991	Digestion of the deamidated rCD4 with endoproteinase Asp-N confirmed Asn-52 as the primary site of deamidation.	Asparagine	69-72	Cd4 molecule	Rattus norvegicus	28-32
2018763-11	1991	Therefore, it appears that Asn-52 is directly involved in binding to gp120.	Asparagine	27-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	69-74
2009524-5	1991	Protein sequence deduced from complementary DNA analysis suggests that GCAP contains two potential sites for asparagine (N)-linked glycosylation.	Asparagine	109-119	alkaline phosphatase, germ cell	Homo sapiens	71-75
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Asparagine	255-258	prolactin receptor	Homo sapiens	89-102
2025301-5	1991	These results suggest that asparagine 415 is located close to the inner glucose binding site and the putative inner gate of GLUT1 glucose transporter and that an ionic charge in this domain might play an important role in the rate of conformational change between an inward-facing form and an outward-facing form of glucose transporter.	Asparagine	27-37	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	124-129
2018763-0	1991	Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120.	Asparagine	30-40	CD4 molecule	Homo sapiens	23-26
2018763-0	1991	Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120.	Asparagine	30-40	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	116-121
2007596-7	1991	The alignment also indicated that the distal helix of cholesterol 7 alpha-hydroxylase contained an asparagine in place of the well conserved threonine that is postulated to be involved in the O2 binding site.	Asparagine	99-109	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	54-85
1874385-3	1991	The A-chain of insulin from the European eel contains an asparagine rather than a serine residue at position A-12.	Asparagine	57-67	insulin	Homo sapiens	15-22
1705996-3	1991	Three different mutations at residue 402 (Asp to Glu, Asn, or His) totally prevented the formation of stable complexes with the cellular protein p53 in monkey cells but had no effect on virus replication.	Asparagine	54-57	transformation related protein 53, pseudogene	Mus musculus	145-148
1849145-7	1991	When compared with the predicted primary structure of human gelsolin a single amino acid substitution is present in amyloid: at position 15 of the amyloid proteins an asparagine is found instead of an aspartic acid residue at the corresponding position (187) in gelsolin.	Asparagine	167-177	gelsolin	Homo sapiens	60-68
2006161-3	1991	Endoproteinase Lys-C or a baby hamster kidney cell protease cleaves angiogenin at the peptide bond either between Lys-60 and Asn-61 or between Glu-67 and Asn-68, respectively.	Asparagine	125-128	ribonuclease A family member k6	Gallus gallus	68-78
2001369-5	1991	The rCD4 molecule has two potential sites for N-glycosylation, Asn-271 and Asn-300.	Asparagine	63-66	Cd4 molecule	Rattus norvegicus	4-8
1847926-2	1991	Using site-directed mutagenesis the N-glycosylation sites of the Mr 46,000 mannose 6-phosphate receptor (MPR 46) were identified as asparagine residues 57, 83, 107, and 113.	Asparagine	132-142	mannose-6-phosphate receptor, cation dependent	Homo sapiens	105-111
1847926-8	1991	Nonglycosylated MPR 46 synthesized in the presence of tunicamycin, thus preserving the asparagine residues, had a normal stability and high affinity binding.	Asparagine	87-97	mannose-6-phosphate receptor, cation dependent	Homo sapiens	16-22
2001369-5	1991	The rCD4 molecule has two potential sites for N-glycosylation, Asn-271 and Asn-300.	Asparagine	75-78	Cd4 molecule	Rattus norvegicus	4-8
1847463-9	1991	However, in the transfected cells, the induction of ODC by asparagine or serum is greatly enhanced at the permissive temperature.	Asparagine	59-69	ornithine decarboxylase 1	Homo sapiens	52-55
1998680-5	1991	The preparation of granzyme B also had significant activity toward Boc-Ala-Ala-AA-SBzl substrates, where AA was Asn, Met, or Ser [kcat/KM = (4-5) X 10(4) M-1 s-1].	Asparagine	112-115	granzyme B	Homo sapiens	19-29
1899840-4	1991	PEP possesses multiple potential nucleic acid- and protein- binding regions: a glycine- and asparagine-rich amino terminus, four zinc finger motifs, two very acidic segments, two short basic stretches, and an alanine- and proline-rich carboxyl terminus.	Asparagine	92-102	Protein on ecdysone puffs	Drosophila melanogaster	0-3
1703043-6	1991	To investigate the possibility that chemotherapeutic drugs induce similar changes, the asparagine auxotrophic cell line N3 was treated with the chemotherapeutic agents L-asparaginase, vincristine, and 1-beta-D-arabinofuranosylcytosine and with the mutagen ethyl methanesulfonate.	Asparagine	87-97	isoaspartyl peptidase/L-asparaginase	Cricetulus griseus	168-182
1703043-7	1991	Both L-asparaginase and ethyl methanesulfonate increased the frequency of reversion to asparagine prototrophy to about 10(-5), whereas vincristine and 1-beta-D-arabinofuranosylcytosine had no such effect.	Asparagine	87-97	isoaspartyl peptidase/L-asparaginase	Cricetulus griseus	5-19
1824702-11	1991	Trypsin proteolysis studies indicate that the [Ala-163]recA and [Asn-160]recA proteins, like the wild-type recA protein, are organized into carboxyl-terminal and amino-terminal domains of nearly equal size.	Asparagine	65-68	RAD51 recombinase	Homo sapiens	73-77
1993068-7	1991	Using this technique we have shown the insulin receptor to be glycosylated at Asn 397 and Asn 881.	Asparagine	78-81	insulin receptor	Homo sapiens	39-55
1993068-7	1991	Using this technique we have shown the insulin receptor to be glycosylated at Asn 397 and Asn 881.	Asparagine	90-93	insulin receptor	Homo sapiens	39-55
1988041-13	1991	These chemical studies established that the active site of human milk BAL is located at serine-194, the N-glycosylation site is present at asparagine-187, the O-glycosylation region is in the 16 repeating units near the C-terminus, and the heparin binding domain is in the N-terminal region.	Asparagine	139-149	carboxyl ester lipase	Homo sapiens	70-73
1899031-0	1991	Oligosaccharide structures present on asparagine-289 of recombinant human plasminogen expressed in a Chinese hamster ovary cell line.	Asparagine	38-48	plasminogen	Homo sapiens	74-85
1824702-11	1991	Trypsin proteolysis studies indicate that the [Ala-163]recA and [Asn-160]recA proteins, like the wild-type recA protein, are organized into carboxyl-terminal and amino-terminal domains of nearly equal size.	Asparagine	65-68	RAD51 recombinase	Homo sapiens	73-77
1824702-12	1991	According to this structural model, the [Ala-163]recA and [Asn-160]recA mutations may lie in a linker region joining these two domains.	Asparagine	59-62	RAD51 recombinase	Homo sapiens	67-71
1898728-2	1991	HUG-Br1 cDNA (2351 base pairs) and HUG-Br2 cDNA (2368 base pairs) encode proteins with 533 and 534 amino acid residues, respectively, with a typical membrane-insertion signal peptide, membrane-spanning domain, and 3 or 5 potential asparagine-linked glycosylation sites.	Asparagine	231-241	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	0-3
1824702-13	1991	We speculate that the [Ala-163]recA and [Asn-160]recA mutations interfere with an ATP-dependent conformational change of the recA protein that perhaps involves a change in the relative orientation of the carboxyl-terminal and amino-terminal domains.	Asparagine	41-44	RAD51 recombinase	Homo sapiens	49-53
1898728-2	1991	HUG-Br1 cDNA (2351 base pairs) and HUG-Br2 cDNA (2368 base pairs) encode proteins with 533 and 534 amino acid residues, respectively, with a typical membrane-insertion signal peptide, membrane-spanning domain, and 3 or 5 potential asparagine-linked glycosylation sites.	Asparagine	231-241	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	35-38
1985932-0	1991	Occurrence of sulfate in an asparagine-linked complex oligosaccharide of chicken adipose lipoprotein lipase.	Asparagine	28-38	lipoprotein lipase	Gallus gallus	89-107
1824702-13	1991	We speculate that the [Ala-163]recA and [Asn-160]recA mutations interfere with an ATP-dependent conformational change of the recA protein that perhaps involves a change in the relative orientation of the carboxyl-terminal and amino-terminal domains.	Asparagine	41-44	RAD51 recombinase	Homo sapiens	49-53
1368675-5	1991	Bombyx PTTH is expected to contain a carbohydrate chain bound to an asparagine at position 41, deduced from the cDNA sequence.	Asparagine	68-78	prothoracicotropic hormone	Bombyx mori	7-11
1993481-0	1991	Reduction of biological activity of murine recombinant interleukin-1 beta by selective deamidation at asparagine-149.	Asparagine	102-112	interleukin 1 beta	Mus musculus	55-73
1993481-2	1991	Treatment with 0.1 M Tris, pH 8.5, at 37 degrees C for 35 h converted the pI 8.7 form to the pI 8.1 form by the selective deamidation of an asparagine residue (Asn149) in the mIL-1 beta molecule.	Asparagine	140-150	interleukin 1 beta	Mus musculus	175-185
1985932-11	1991	The data show that chicken LPL contains two complex and one high mannose N-linked oligosaccharides and that 35SO4 is incorporated into LPL on a GlcNAc residue of a complex oligosaccharide located at Asn-45.	Asparagine	199-202	lipoprotein lipase	Gallus gallus	27-30
1985932-11	1991	The data show that chicken LPL contains two complex and one high mannose N-linked oligosaccharides and that 35SO4 is incorporated into LPL on a GlcNAc residue of a complex oligosaccharide located at Asn-45.	Asparagine	199-202	lipoprotein lipase	Gallus gallus	135-138
1824693-8	1991	The sensitivity of the neuromodulin/calmodulin binding interaction to negative charge at serine 41 was determined by substitution of serine 41 with an aspartate or an asparagine residue.	Asparagine	167-177	growth associated protein 43	Homo sapiens	23-35
1824693-8	1991	The sensitivity of the neuromodulin/calmodulin binding interaction to negative charge at serine 41 was determined by substitution of serine 41 with an aspartate or an asparagine residue.	Asparagine	167-177	calmodulin 1	Homo sapiens	36-46
1824693-9	1991	The asparagine mutant retained its affinity for calmodulin-Sepharose while the aspartate mutant did not adsorb to calmodulin-Sepharose.	Asparagine	4-14	calmodulin 1	Homo sapiens	48-58
2268312-8	1990	Digestion of purified isoforms with a battery of glycosidic enzymes indicate that secreted forms of murine TNF contain both sialic acid and asparagine(N)-linked chains.	Asparagine	140-150	tumor necrosis factor	Mus musculus	107-110
1851025-1	1991	Human chorionic gonadotropin (hCG) purified from the urine of a male patient with extragonadal germ cell tumour contained four asparagine-linked sugar chains in one molecule.	Asparagine	127-137	chorionic gonadotropin subunit beta 5	Homo sapiens	6-34
1904406-0	1991	Degradation of growth hormone releasing factor analogs in neutral aqueous solution is related to deamidation of asparagine residues.	Asparagine	112-122	growth hormone releasing hormone	Homo sapiens	15-46
1670638-9	1991	In addition, by polymerase chain reaction amplification and sequencing of 740 bp of the 5" part of TNF-beta of individuals typed homozygously for the NcoI RFLP, we could show that amino acid position 26 is conserved as asparagine in the TNFB*1 and as threonine in the TNFB*2 sequence.	Asparagine	219-229	lymphotoxin alpha	Homo sapiens	99-107
1963688-3	1990	Mutant t-PA molecules were constructed by site-directed mutagenesis in which one or two of the five aspartic or glutamic acid residues in K2 were changed to asparagine or glutamine respectively.	Asparagine	157-167	plasminogen activator, tissue type	Homo sapiens	7-11
2176481-0	1990	Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.	Asparagine	18-21	gelsolin	Homo sapiens	0-8
2176481-7	1990	We designate this variant of gelsolin-associated amyloidosis "Agel Asn-187".	Asparagine	67-70	gelsolin	Homo sapiens	29-37
2174833-5	1990	N-terminal amino acids of this 79-kDa HlyA protein and those of a 65-kDa El Tor cytolysin purified from V. cholerae were Asn-26 and Asn-158, respectively.	Asparagine	121-124	hemolysin transport protein	Escherichia coli	38-42
2174833-5	1990	N-terminal amino acids of this 79-kDa HlyA protein and those of a 65-kDa El Tor cytolysin purified from V. cholerae were Asn-26 and Asn-158, respectively.	Asparagine	132-135	hemolysin transport protein	Escherichia coli	38-42
2081780-5	1990	Ovine fetal IGF II was found to differ from human IGF II in three residues of the C-domain, with serine, isoleucine and asparagine substituted for alanine, valine and serine, respectively, at positions 32, 35 and 36.	Asparagine	120-130	insulin like growth factor 2	Homo sapiens	12-18
2082620-2	1990	To address the possible role of N-glycosylation of HIV-1 gp120 in binding CD4, we mutated different conserved N-glycosylation site Asn-residues in the vicinity of the putative CD4 binding site, as single mutations or in combinations.	Asparagine	131-134	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	57-62
2082620-2	1990	To address the possible role of N-glycosylation of HIV-1 gp120 in binding CD4, we mutated different conserved N-glycosylation site Asn-residues in the vicinity of the putative CD4 binding site, as single mutations or in combinations.	Asparagine	131-134	CD4 molecule	Homo sapiens	176-179
2243102-6	1990	Amino acid analysis and sequencing demonstrated that polylactosaminoglycans were located at Asn-34, Asn-93 and/or Asn-102, and Asn-195 and/or Asn-200 in lamp-1, and at Asn-4 and/or Asn-10, and Asn-279 in lamp-2.	Asparagine	92-95	lysosomal associated membrane protein 1	Homo sapiens	153-159
2243109-1	1990	The small keratan sulfate-substituted proteoglycan (fibromodulin) from articular cartilage was shown to contain keratan sulfate linked to the core protein through N-glycosidic linkages to residues Asn-109, Asn-147, Asn-182, and Asn-272.	Asparagine	197-200	fibromodulin	Bos taurus	52-64
2261983-5	1990	The 12 cysteines and the glycosylated asparagines in the porcine enzyme are absolutely conserved in number and position within all known acrosin sequences.	Asparagine	38-49	acrosin	Homo sapiens	137-144
2243109-1	1990	The small keratan sulfate-substituted proteoglycan (fibromodulin) from articular cartilage was shown to contain keratan sulfate linked to the core protein through N-glycosidic linkages to residues Asn-109, Asn-147, Asn-182, and Asn-272.	Asparagine	206-209	fibromodulin	Bos taurus	52-64
2243109-1	1990	The small keratan sulfate-substituted proteoglycan (fibromodulin) from articular cartilage was shown to contain keratan sulfate linked to the core protein through N-glycosidic linkages to residues Asn-109, Asn-147, Asn-182, and Asn-272.	Asparagine	206-209	fibromodulin	Bos taurus	52-64
2243109-1	1990	The small keratan sulfate-substituted proteoglycan (fibromodulin) from articular cartilage was shown to contain keratan sulfate linked to the core protein through N-glycosidic linkages to residues Asn-109, Asn-147, Asn-182, and Asn-272.	Asparagine	206-209	fibromodulin	Bos taurus	52-64
2243109-8	1990	Hence, all four Asn residues in the leucine-rich region of the fibromodulin core protein can serve as acceptor sites for keratan sulfate addition.	Asparagine	16-19	fibromodulin	Bos taurus	63-75
2226832-4	1990	Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145.	Asparagine	67-70	azurocidin 1	Homo sapiens	16-21
2174119-1	1990	Glycosylated chimeric mouse-human anti-NIP IgG3 antibody produced by growth of the J558L mouse B cell plasmacytoma is characterised with respect to the single carbohydrate chain at Asn-297 in the CH2 domain indicating that the mouse cell glycosyl transferases dictate the pattern of glycosylation rather than the human CH region of the heavy chain.	Asparagine	181-184	Immunoglobulin heavy constant gamma 3	Mus musculus	43-47
2170418-6	1990	These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR.	Asparagine	46-49	insulin receptor	Cricetulus griseus	73-75
2170418-6	1990	These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR.	Asparagine	46-49	insulin-like growth factor 1 receptor	Cricetulus griseus	115-120
2290356-1	1990	Triosephosphate isomerase (TPI) from mammals undergoes two specific deamidations (Asn-15 and Asn-71) which destabilize the isologous dimer and lead to the degradation of the protein.	Asparagine	82-85	triosephosphate isomerase 1	Gallus gallus	0-25
2290356-1	1990	Triosephosphate isomerase (TPI) from mammals undergoes two specific deamidations (Asn-15 and Asn-71) which destabilize the isologous dimer and lead to the degradation of the protein.	Asparagine	82-85	triosephosphate isomerase 1	Gallus gallus	27-30
2290356-1	1990	Triosephosphate isomerase (TPI) from mammals undergoes two specific deamidations (Asn-15 and Asn-71) which destabilize the isologous dimer and lead to the degradation of the protein.	Asparagine	93-96	triosephosphate isomerase 1	Gallus gallus	0-25
2290356-1	1990	Triosephosphate isomerase (TPI) from mammals undergoes two specific deamidations (Asn-15 and Asn-71) which destabilize the isologous dimer and lead to the degradation of the protein.	Asparagine	93-96	triosephosphate isomerase 1	Gallus gallus	27-30
2226832-4	1990	Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145.	Asparagine	92-95	azurocidin 1	Homo sapiens	16-21
2226832-4	1990	Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145.	Asparagine	92-95	azurocidin 1	Homo sapiens	16-21
2121479-7	1990	Of the oligosaccharides 29% have an alpha 1-6-linked Fuc residue at the asparagine-bound GlcNAc, whereas this amount is about 50% in pituitary follitropin.	Asparagine	72-82	adrenoceptor alpha 1D	Homo sapiens	36-45
2226832-4	1990	Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145.	Asparagine	92-95	azurocidin 1	Homo sapiens	16-21
2226797-1	1990	The carbohydrate structures of a genetically engineered human tissue plasminogen activator variant bearing a single N-glycosylation site at Asn 448 are reported.	Asparagine	140-143	chromosome 20 open reading frame 181	Homo sapiens	62-90
2212861-6	1990	Nonenzymatic glycosylation of lysyl residues and deamination of the NH2-terminal asparagine of platelet-derived CTAP-III were commonly present, but did not correlate with the biologic activities that were measured.	Asparagine	81-91	pro-platelet basic protein	Homo sapiens	112-120
2172449-3	1990	Here, it is shown that the ts mutant phenotype is due to the substitution of an asparagine for the wild-type (wt) serine at RR1 position 961, which is located within a region highly conserved between herpesviral and cellular RR1 subunit polypeptides.	Asparagine	80-90	ribonucleotide reductase catalytic subunit M1	Homo sapiens	124-127
2172449-3	1990	Here, it is shown that the ts mutant phenotype is due to the substitution of an asparagine for the wild-type (wt) serine at RR1 position 961, which is located within a region highly conserved between herpesviral and cellular RR1 subunit polypeptides.	Asparagine	80-90	ribonucleotide reductase catalytic subunit M1	Homo sapiens	225-228
1976872-4	1990	These results suggest that asparagine synthetase or L-asparagine has some biological function in growth regulation of these leukemia cell lines.	Asparagine	52-64	asparagine synthetase	Mus musculus	27-48
2284201-4	1990	The amino acid sequence of the peptide, Ala-Leu-Asn-Ser-Val-Ala-Tyr-Glu-Arg-Ser-Ala-Met-Gln-Asn-Tyr-Glu, indicates identity with beta-preprotachykinin(111-126)-peptide.	Asparagine	48-51	tachykinin precursor 1	Homo sapiens	134-150
2118993-1	1990	We used a dominant inhibitory mutation of c-Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21(Asn-17)Ha-ras] to investigate ras function in mitogenic signal transduction.	Asparagine	75-78	POC1 centriolar protein A	Mus musculus	42-46
2118993-1	1990	We used a dominant inhibitory mutation of c-Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21(Asn-17)Ha-ras] to investigate ras function in mitogenic signal transduction.	Asparagine	75-78	Harvey rat sarcoma virus oncogene	Mus musculus	44-50
2118993-2	1990	An NIH 3T3 cell line [NIH(M17)] was isolated that displayed inducible expression of the mutant Ha-ras gene (Ha-ras Asn-17) via the mouse mammary tumor virus long terminal repeat and was growth inhibited by dexamethasone.	Asparagine	115-118	Harvey rat sarcoma virus oncogene	Mus musculus	95-101
2118993-2	1990	An NIH 3T3 cell line [NIH(M17)] was isolated that displayed inducible expression of the mutant Ha-ras gene (Ha-ras Asn-17) via the mouse mammary tumor virus long terminal repeat and was growth inhibited by dexamethasone.	Asparagine	115-118	Harvey rat sarcoma virus oncogene	Mus musculus	108-114
2118993-8	1990	In contrast to its effect on DNA synthesis, however, Ha-ras Asn-17 expression did not inhibit fos-cat expression induced by TPA.	Asparagine	60-63	Harvey rat sarcoma virus oncogene	Mus musculus	53-59
2118994-1	1990	A dominant inhibitory mutation of Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21 (Asn-17)Ha-ras] has been used to investigate the role of ras in neuronal differentiation of PC12 cells.	Asparagine	65-68	Harvey rat sarcoma virus oncogene	Mus musculus	34-40
2118994-1	1990	A dominant inhibitory mutation of Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21 (Asn-17)Ha-ras] has been used to investigate the role of ras in neuronal differentiation of PC12 cells.	Asparagine	65-68	KRAS proto-oncogene, GTPase	Rattus norvegicus	92-95
1967025-1	1990	Human chorionic gonadotropin (hCG) purified from pooled urine of normal pregnant women contains four asparagine-linked sugar chains and four mucin-type sugar chains.	Asparagine	101-111	chorionic gonadotropin subunit beta 5	Homo sapiens	30-33
2165498-5	1990	Elastase-digested thrombin, which was cleaved between Ala-150 and Asn-151, lost its binding affinity for both MT-6 and thrombomodulin.	Asparagine	66-69	coagulation factor II, thrombin	Homo sapiens	18-26
1695899-3	1990	The rat beta 1-AR gene encodes a protein of 466 amino acids that contains one consensus site for N-linked glycosylation (Asn-15) and three consensus sites for cAMP-dependent protein kinase phosphorylation (Ser-296, Ser-301, and Ser-401).	Asparagine	121-124	adrenoceptor beta 1	Rattus norvegicus	8-17
2165498-5	1990	Elastase-digested thrombin, which was cleaved between Ala-150 and Asn-151, lost its binding affinity for both MT-6 and thrombomodulin.	Asparagine	66-69	thrombomodulin	Homo sapiens	110-133
2373681-1	1990	Human erythropoietin contains three Asn-type and one mucin-type sugar chains.	Asparagine	36-39	erythropoietin	Homo sapiens	6-20
2201025-2	1990	Microsequencing showed that HIV-1 PR cleaved both human and murine vimentin between leucine-422 and arginine-423 within the sequence between positions 418 and 427, Ser-Ser-Leu-Asn-Leu/Arg-Glu-Thr-Asn-Leu (SSLNL/RETNL).	Asparagine	176-179	vimentin	Mus musculus	67-75
2201025-2	1990	Microsequencing showed that HIV-1 PR cleaved both human and murine vimentin between leucine-422 and arginine-423 within the sequence between positions 418 and 427, Ser-Ser-Leu-Asn-Leu/Arg-Glu-Thr-Asn-Leu (SSLNL/RETNL).	Asparagine	196-199	vimentin	Mus musculus	67-75
2373681-12	1990	Sequential removal of galactose and N-acetylglucosamine from the outer chain moieties of the desialylated Asn-type sugar chains raised the activity of the hormone up to four and five times the intact erythropoietin, respectively.	Asparagine	106-109	erythropoietin	Homo sapiens	200-214
2373681-15	1990	These results indicate that the core portion of the Asn-type sugar chains is necessary for erythropoietin to express its full biological activity in vitro and suggest that removal of the core portion of the sugar chains destroys the active conformation of erythropoietin.	Asparagine	52-55	erythropoietin	Homo sapiens	91-105
2373681-15	1990	These results indicate that the core portion of the Asn-type sugar chains is necessary for erythropoietin to express its full biological activity in vitro and suggest that removal of the core portion of the sugar chains destroys the active conformation of erythropoietin.	Asparagine	52-55	erythropoietin	Homo sapiens	256-270
2141816-2	1990	Here, we determined the in vitro and in vivo bioactivity of recombinant FSH produced by CHO mutant cells deficient in the glycosylation enzyme N-acetylglucosamine transferase-I (NAGT-), resulting in glycoproteins with asparagine-linked (GlcNAc)2(Mannose)5 oligosaccharides, or mutant cells defective in sialic acid transport into the Golgi (ST-).	Asparagine	218-228	solute carrier family 5 member 1	Homo sapiens	178-182
2198287-7	1990	The residue His-391 in the recombinant inner-core domain (E2b delta 167) was changed to Asn or Gln by site-directed mutagenesis.	Asparagine	88-91	dihydrolipoamide branched chain transacylase E2	Bos taurus	58-61
2116966-1	1990	It has been recently reported that, in Xenopus oocytes injected with the mRNA for human renin, this secretory renal glycoprotein acquires phosphomannosyl residues on its asparagine-linked oligosaccharide chains, remains intracellular and undergoes a proteolytic cleavage which removes the prosegment.	Asparagine	170-180	renin	Homo sapiens	88-93
2169760-2	1990	The primers used derived from the cDNA sequence of active sites Ser* and Asn* of human furin.	Asparagine	73-76	furin, paired basic amino acid cleaving enzyme	Homo sapiens	87-92
2113058-2	1990	We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis.	Asparagine	65-75	immunoglobulin heavy constant mu	Mus musculus	30-33
1980286-5	1990	In addition, L-asparaginase loaded into erythrocytes was much more effective in eliminating plasma asparagine compared with the same dose of free L-asparaginase injected in solution, during a sustained period (14 days).	Asparagine	99-109	asparaginase like 1	Mus musculus	13-27
2113058-2	1990	We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis.	Asparagine	65-75	immunoglobulin heavy constant mu	Mus musculus	51-54
1693954-6	1990	CGRP (10(-7) M) caused a significant, largely Ca2(+)-independent increase in the basal release of Glu and Asp and a decrease in asparagine.	Asparagine	128-138	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2113770-2	1990	Asparagine (Asn; 10 mM) or 10% fetal bovine serum (FBS) increased ODC activity from undetectable levels to greater than 500 pmol CO2.mg protein-1.h-1 in 4 h. This increase could be reduced 50% by concentrations of Na(+)-H+ exchange inhibitors that did not reduce protein synthesis.	Asparagine	0-10	ornithine decarboxylase 1	Homo sapiens	66-69
2113770-2	1990	Asparagine (Asn; 10 mM) or 10% fetal bovine serum (FBS) increased ODC activity from undetectable levels to greater than 500 pmol CO2.mg protein-1.h-1 in 4 h. This increase could be reduced 50% by concentrations of Na(+)-H+ exchange inhibitors that did not reduce protein synthesis.	Asparagine	12-15	ornithine decarboxylase 1	Homo sapiens	66-69
2113770-4	1990	Asn was able to double the uptake of 22Na+, whether an ionic (choline chloride) or nonionic (D-mannitol) substance was substituted for Na+, and the substitution of these compounds as well as N-methyl-glucamine for Na+ largely prevented the stimulation of ODC by Asn.	Asparagine	0-3	ornithine decarboxylase 1	Homo sapiens	255-258
2318821-7	1990	Using site-specific mutagenesis, Ala residues were substituted for Asn residues at two potential N-linked glycosylation sites (positions 43 and 359) and at a third unrelated Asn (position 257) in the LPL cDNA.	Asparagine	174-177	lipoprotein lipase	Homo sapiens	200-203
2341397-5	1990	This approach showed that TEX and NCA were identical with respect to primary sequence and provided direct evidence that 11 of the 12 predicted asparagine-linked glycosylation sites were glycosylated in both TEX and NCA.	Asparagine	143-153	CEA cell adhesion molecule 4	Homo sapiens	34-37
2341397-5	1990	This approach showed that TEX and NCA were identical with respect to primary sequence and provided direct evidence that 11 of the 12 predicted asparagine-linked glycosylation sites were glycosylated in both TEX and NCA.	Asparagine	143-153	CEA cell adhesion molecule 4	Homo sapiens	215-218
2189404-4	1990	We demonstrate herein that the novel beta 2m has the same sequence as native beta 2m except for the 17th residue from the N-terminus which was identified as Asp instead of Asn in native beta 2m, suggesting a possible deamidation during LT-HD.	Asparagine	172-175	beta-2-microglobulin	Homo sapiens	37-44
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Asparagine	130-133	pro-platelet basic protein	Homo sapiens	0-20
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Asparagine	130-133	pro-platelet basic protein	Homo sapiens	22-29
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Asparagine	130-133	pro-platelet basic protein	Homo sapiens	78-86
2111847-4	1990	In this report, the published sequences of the mitochondrial genes for COI and ND1 in a platyhelminth (Fasciola hepatica) are examined and it is concluded that AAA may be a codon for asparagine instead of lysine, whereas AAG is the sole codon for lysine in this species.	Asparagine	183-193	ND1	Fasciola hepatica	79-82
1367433-0	1990	Alterations in the domain structure of tissue-type plasminogen activator change the nature of asparagine glycosylation.	Asparagine	94-104	plasminogen activator, tissue	Mus musculus	39-72
1367433-6	1990	We found that with one exception, all mutant activators lack the high mannose glycan found at asn 117 of native t-PA.	Asparagine	94-97	plasminogen activator, tissue	Mus musculus	112-116
2327073-12	1990	Indeed, two potential asparagine-linked glycosylation sites are present on the spheroidin molecule.	Asparagine	22-32	spheroidin	Choristoneura biennis entomopoxvirus	79-89
1691502-7	1990	Characterization of mAb LA22-reactive 125I-EGF-labeled receptor fragments generated by an endoproteinase specific for the COOH side of lysyl residue placed the NH2 termini of the two smallest fragments between the glycosylated residues Asn-328 and Asn-337.	Asparagine	236-239	epidermal growth factor	Homo sapiens	43-46
1691502-7	1990	Characterization of mAb LA22-reactive 125I-EGF-labeled receptor fragments generated by an endoproteinase specific for the COOH side of lysyl residue placed the NH2 termini of the two smallest fragments between the glycosylated residues Asn-328 and Asn-337.	Asparagine	248-251	epidermal growth factor	Homo sapiens	43-46
1691502-8	1990	These results indicated that disuccinimidyl suberate cross-linked the NH2 group of EGF residue Asn-1 to the human EGF receptor residue Lys-336.	Asparagine	95-98	epidermal growth factor	Homo sapiens	83-86
1691502-8	1990	These results indicated that disuccinimidyl suberate cross-linked the NH2 group of EGF residue Asn-1 to the human EGF receptor residue Lys-336.	Asparagine	95-98	epidermal growth factor	Homo sapiens	114-117
2337584-14	1990	Asparagine was found to form cyclic imides (64%) at the penultimate position (C-2) during hydrolysis of the peptidylthiohydantoins by 2% aqueous triethylamine.	Asparagine	0-10	complement C2	Homo sapiens	78-81
2186807-3	1990	Recombinant renin contains carbohydrate covalently attached to asparagines at positions 5 and 75 (renin numbering) and disulfide linkages at Cys-51/Cys-58, Cys-217/Cys-221, and Cys-259/Cys-296.	Asparagine	63-74	renin	Homo sapiens	12-17
2110822-0	1990	Characteristics of asparagine-linked sugar chains of sphingolipid activator protein 1 purified from normal human liver and GM1 gangliosidosis (type 1) liver.	Asparagine	19-29	prosaposin	Homo sapiens	53-85
2110822-1	1990	Asparagine-linked sugar chains of sphingolipid activator protein 1 (SAP-1) purified from normal human liver and GM1 gangliosidosis (type 1) liver were comparatively investigated.	Asparagine	0-10	prosaposin	Homo sapiens	34-66
2110822-1	1990	Asparagine-linked sugar chains of sphingolipid activator protein 1 (SAP-1) purified from normal human liver and GM1 gangliosidosis (type 1) liver were comparatively investigated.	Asparagine	0-10	prosaposin	Homo sapiens	68-73
2318210-14	1990	The tryptic map of rCD4 treated with endo-beta-N-acetylglucosamine H demonstrated that only complex-type oligosaccharides are attached to Asn-271, while Asn-300 has high-mannose or hybrid structures attached in addition to complex-type oligosaccharides.	Asparagine	138-141	Cd4 molecule	Rattus norvegicus	19-23
2105951-5	1990	The aldose reductase was shown to contain no carbohydrate despite the fact that the enzyme contains the consensus sequence -Asn-Lys-Thr- for N-linked glycosylation.	Asparagine	124-127	aldose reductase	Bos taurus	4-20
2106270-9	1990	In contrast, 10(-7) M putrescine prevented 80% of the ODC activity stimulated by asparagine in IEC-6 cells (a rat intestinal crypt cell line).	Asparagine	81-91	ornithine decarboxylase 1	Rattus norvegicus	54-57
2354880-3	1990	A convenient and effective method to prepare peptides with C-terminal asparagine or glutamine involves quantitative attachment of N alpha-Fmoc-C alpha-tert.-butyl aspartate or glutamate via the free omega-carboxyl groups to a tris(alkoxy)benzylamino (PAL) support.	Asparagine	70-80	SHC binding and spindle associated 1	Homo sapiens	251-254
2354880-5	1990	Feasibility of the approach has been demonstrated by the syntheses of the C-terminal octapeptide from human proinsulin, H-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH, and the serum thymic factor pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.	Asparagine	219-222	insulin	Homo sapiens	108-118
2160449-5	1990	The Mr of the inhibitor was reduced by treatment with neuraminidase, O-glycanase, and also with glycopeptidase-A, suggesting that the inhibitor has both Asn-linked and Ser/Thr-linked carbohydrate chains.	Asparagine	153-156	neuraminidase 1	Homo sapiens	54-67
2106270-10	1990	The half-life of ODC in unstimulated IEC-6 cells was 20 min and increased to 35 min in cells exposed to 10 mM asparagine.	Asparagine	110-120	ornithine decarboxylase 1	Rattus norvegicus	17-20
2153547-5	1990	With asparagine as substrate, 0.5 mM adenosine increased gluconeogenesis; this increase was due to adenosine conversion through adenosine deaminase.	Asparagine	5-15	adenosine deaminase	Rattus norvegicus	128-147
2153547-6	1990	However, adenosine conversion through adenosine kinase inhibited gluconeogenesis from asparagine.	Asparagine	86-96	adenosine kinase	Rattus norvegicus	38-54
2104831-1	1990	Using site-directed mutagenesis, we have changed the asparagine in human single-chain urinary plasminogen activator (u-PA) at position 302 to an alanine.	Asparagine	53-63	plasminogen activator, urokinase	Homo sapiens	117-121
2105083-7	1990	A peptide analogous to the calcium binding regions of calmodulin, Asp-Lys-Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys-Glu, is also converted, upon heating, to chromatographically different forms in reversed-phase chromatography.	Asparagine	82-85	calmodulin 1	Homo sapiens	54-64
33800773-7	2021	Survival analysis showed an accelerated disease progression of individuals infected with HIV-1 carrying arginine or asparagine at position 8 or 157 in Nef, respectively, or the R178G Nef mutation.	Asparagine	116-126	S100 calcium binding protein B	Homo sapiens	151-154
1967152-8	1990	These results indicate that the transformational changes of pancreatic cancer gamma-GTP are mainly induced in the sugar chains of the enzyme molecule, resulting in lower content of sialic acid and higher content of fucose and bisecting GlcNAc residue (the beta-N-acetylglucosamine residue linked at the C-4 of the beta-mannosyl residue of the trimannosyl core of the asparagine-linked sugar chain) as compared with the normal pancreatic enzyme.	Asparagine	367-377	inactive glutathione hydrolase 2	Homo sapiens	78-87
33800686-4	2021	In this study, we investigated whether the PD-causative 620 aspartate (D) to asparagine (N) mutation in the vacuolar protein sorting 35 ortholog (Vps35) precipitated herpes simplex virus (HSV) infection.	Asparagine	77-87	VPS35 retromer complex component	Homo sapiens	146-151
2271010-3	1990	The affinity of native hirudin does not differ significantly from that of recombinant hirudin Lys-47 whereas a distinctly lower affinity for thrombin is found for recombinant hirudin Arg-47 and recombinant hirudin Asn-47.	Asparagine	214-217	coagulation factor II, thrombin	Homo sapiens	141-149
2342986-3	1990	Canine PYY(1-36) has the identical sequence as porcine and rat PYY but differs from human PYY at position 3, with Ala instead of Ile, and position 18, with Ser instead of Asn.	Asparagine	171-174	peptide YY	Canis lupus familiaris	7-10
33777794-0	2021	Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma.	Asparagine	31-43	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
33777794-6	2021	Then, the key enzyme of l-asparagine, asparagine synthetase (ASNS), was investigated using immunohistochemistry with 86 OSCC patients.	Asparagine	24-36	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	38-59
33777794-6	2021	Then, the key enzyme of l-asparagine, asparagine synthetase (ASNS), was investigated using immunohistochemistry with 86 OSCC patients.	Asparagine	24-36	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	61-65
33777794-12	2021	Besides, CAL33 migrated significantly farther than HSC3 in the nerve microenvironment (P = 0.0003), indicating high ASNS expression is indispensable for OSCC progression, especially PNI formation, through l-asparagine metabolism alteration.	Asparagine	205-217	asparagine synthetase	Mus musculus	116-120
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Asparagine	116-119	adenosylhomocysteinase like 1	Homo sapiens	24-29
33801449-7	2021	The inclusion of a glycosylated asparagine (N) at position 487 did increase the molecular mass and provided a channel whose SF response was abolished following ECM degradation via hyaluronidase.	Asparagine	32-42	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog	Xenopus laevis	180-193
34969094-4	2022	For example, it is now known that NGLY1 can also act as an "editing enzyme" to convert N-glycosylated asparagine residues to aspartate residues, thus introducing negative charges into a core peptide and modulating the function of the target molecule.	Asparagine	102-112	N-glycanase 1	Homo sapiens	34-39
30988517-3	2019	Here, we examined the synaptic effects of rat Mint2 N723S mutation (equivalent to autism-linked human MINT2 N722S mutation) which targets a conserved asparagine residue in the second PDZ domain of Mint2 that binds to neurexin-1alpha (Nrxn1alpha), a presynaptic cell-adhesion protein implicated in ASDs.	Asparagine	150-160	amyloid beta precursor protein binding family A member 2	Homo sapiens	102-107
30988517-3	2019	Here, we examined the synaptic effects of rat Mint2 N723S mutation (equivalent to autism-linked human MINT2 N722S mutation) which targets a conserved asparagine residue in the second PDZ domain of Mint2 that binds to neurexin-1alpha (Nrxn1alpha), a presynaptic cell-adhesion protein implicated in ASDs.	Asparagine	150-160	amyloid beta precursor protein binding family A member 2	Homo sapiens	197-202
34416429-9	2022	To destabilize mutant p53, we targeted RNF128 Iso1 either by mutating asparagine (N48, 59 and 101) residues to block glycosylation to facilitate beta-TrCP1-mediated degradation or by mutating proline (P54 and 105) residues to restore p53 polyubiquitinating ability.	Asparagine	70-80	tripartite motif containing 31	Homo sapiens	39-50
30988517-3	2019	Here, we examined the synaptic effects of rat Mint2 N723S mutation (equivalent to autism-linked human MINT2 N722S mutation) which targets a conserved asparagine residue in the second PDZ domain of Mint2 that binds to neurexin-1alpha (Nrxn1alpha), a presynaptic cell-adhesion protein implicated in ASDs.	Asparagine	150-160	amyloid beta precursor protein binding family A member 2	Rattus norvegicus	46-51
19214747-1	2009	Mannosylphospho dolichol synthase (DPMS) is a critical enzyme in the biosynthesis of lipid-linked oligosaccharide (LLO; Glc(3)Man(9)GlcNAc(2)-PP-Dol), a pre-requisite for asparagine-linked (N-linked) protein glycosylation.	Asparagine	171-181	dolichyl-phosphate mannosyltransferase subunit 1, catalytic	Bos taurus	35-39
8535240-9	1995	Three putative N-glycosylation sites (Asn 63, Asn 85, and Asn 193) are present in bovine osteopontin, but sequence and mass spectrometric analysis showed that none of these asparagines were glycosylated in bovine mammary gland osteopontin.	Asparagine	38-41	secreted phosphoprotein 1	Bos taurus	89-100
34808209-4	2022	Here, we report a novel disease-causing, in-frame insertion in the ATL1 gene, leading to inclusion of an additional asparagine residue at position 417 (N417ins).	Asparagine	116-126	atlastin GTPase 1	Homo sapiens	67-71
34450268-3	2021	Covalent modification of cholesterol on the 95th asparagine (D95) of human SMO, which is regulated by Hh and PTCH1, is critical for SMO activation.	Asparagine	49-59	smoothened, frizzled class receptor	Homo sapiens	75-78
34617390-0	2022	Nicotiana benthamiana asparagine synthetase associates with IP-L and confers resistance against tobacco mosaic virus via the asparagine-induced salicylic acid signalling pathway.	Asparagine	125-135	asparagine synthetase	None	22-43
34617390-0	2022	Nicotiana benthamiana asparagine synthetase associates with IP-L and confers resistance against tobacco mosaic virus via the asparagine-induced salicylic acid signalling pathway.	Asparagine	125-135	pleckstrin homology like domain family A member 2	Homo sapiens	60-64
34976799-14	2021	Bioinformatics analysis showed that ATF4 could promote GC progression possibly by regulating asparagine (Asn) metabolism and autophagy pathways.	Asparagine	93-103	activating transcription factor 4	Homo sapiens	36-40
34976799-14	2021	Bioinformatics analysis showed that ATF4 could promote GC progression possibly by regulating asparagine (Asn) metabolism and autophagy pathways.	Asparagine	105-108	activating transcription factor 4	Homo sapiens	36-40
34704268-6	2021	Mechanistically, asparagine stimulated the mTORC1 pathway, which promoted expression of thermogenic genes and key enzymes in glycolysis.	Asparagine	17-27	CREB regulated transcription coactivator 1	Mus musculus	43-49
34863021-3	2022	However, knowledge of the role of FVIII asparagine (N)-linked glycosylation in FVIII immunity is limited.	Asparagine	40-50	coagulation factor VIII	Mus musculus	34-39
34863021-3	2022	However, knowledge of the role of FVIII asparagine (N)-linked glycosylation in FVIII immunity is limited.	Asparagine	40-50	coagulation factor VIII	Mus musculus	79-84
34937426-7	2022	Finally, we determined the effect of tunicamycin, a pharmacological inhibitor of N-linked glycosylation, and targeted mutations in Asn residues on SLC17A4 function.	Asparagine	131-134	solute carrier family 17 member 4	Homo sapiens	147-154
34704268-0	2021	Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.	Asparagine	0-10	CREB regulated transcription coactivator 1	Mus musculus	22-28
34704268-4	2021	In mice with diet-induced obesity, the asparagine-fed group was more responsive to beta3-adrenergic receptor agonists, manifesting in blunted body weight gain and improved glucose tolerance.	Asparagine	39-49	adrenergic receptor, beta 3	Mus musculus	83-108
34851640-7	2021	By virtue of the highly structural stability and excellent biocompatibility, the orientation-independent cages can be molecularly embedded into lipid membranes, biomimetically serving as single-molecular chiral channels for polar-residue amino acids, with the properties that cage-1 featuring hydroxyl groups preferentially transports the l-asparagine, whereas cage-2 attaching crown ether groups spontaneously favor transporting d-arginine.	Asparagine	339-351	cancer antigen 1	Homo sapiens	276-282
34614505-4	2021	In turn, MSCs use glutamine, either synthesized through Glutamine Synthetase (GS) or imported, to produce asparagine, which is then extruded to sustain asparagine-auxotroph leukemic cells.	Asparagine	106-116	glutamate-ammonia ligase	Homo sapiens	56-76
34614505-6	2021	The pro-survival amino acid exchange is hindered by the inhibition or silencing of the asparagine efflux transporter SNAT5, which is induced in mesenchymal cells by ALL blasts.	Asparagine	87-97	solute carrier family 38 member 5	Homo sapiens	117-122
34450268-3	2021	Covalent modification of cholesterol on the 95th asparagine (D95) of human SMO, which is regulated by Hh and PTCH1, is critical for SMO activation.	Asparagine	49-59	patched 1	Homo sapiens	109-114
34450268-3	2021	Covalent modification of cholesterol on the 95th asparagine (D95) of human SMO, which is regulated by Hh and PTCH1, is critical for SMO activation.	Asparagine	49-59	smoothened, frizzled class receptor	Homo sapiens	132-135
34982449-5	2021	The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels.	Asparagine	40-50	sodium voltage-gated channel alpha subunit 9	Homo sapiens	103-108
34543685-0	2021	Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.	Asparagine	38-48	KRAS proto-oncogene, GTPase	Homo sapiens	105-109
34543685-8	2021	In KRAS-mutant CRC cells engineered with knockdown of asparagine synthetase, macropinocytosis was accelerated under glutamine-depleted condition, and albumin addition could restore the glutamine depletion-induced growth suppression by recovering the intracellular asparagine level.	Asparagine	54-64	KRAS proto-oncogene, GTPase	Homo sapiens	3-7
34543685-8	2021	In KRAS-mutant CRC cells engineered with knockdown of asparagine synthetase, macropinocytosis was accelerated under glutamine-depleted condition, and albumin addition could restore the glutamine depletion-induced growth suppression by recovering the intracellular asparagine level.	Asparagine	264-274	KRAS proto-oncogene, GTPase	Homo sapiens	3-7
34543685-9	2021	Finally, we discovered that the combination of macropinocytosis inhibition and asparagine depletion dramatically suppressed the tumor growth of KRAS-mutant CRC cells in vivo.	Asparagine	79-89	KRAS proto-oncogene, GTPase	Homo sapiens	144-148
34543685-10	2021	These results indicate that dual blockade of macropinocytosis and asparagine bioavailability could be a novel therapeutic strategy for KRAS-mutant cancers.	Asparagine	66-76	KRAS proto-oncogene, GTPase	Homo sapiens	135-139
34982449-5	2021	The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels.	Asparagine	52-55	sodium voltage-gated channel alpha subunit 9	Homo sapiens	103-108
34784468-1	2021	Hindered rotation about an sp2 C-N bond is known to occur in arginine (Arg), asparagine (Asn), and glutamine (Gln) side chains of proteins.	Asparagine	77-87	Sp2 transcription factor	Homo sapiens	27-30
34917801-5	2021	delta-secretase, also known as asparagine endopeptidase (AEP) or legumain (LGMN), is a lysosomal cysteine protease that cleaves peptide bonds C-terminally to asparagine residues in both amyloid precursor protein (APP) and tau, mediating the amyloid-beta and tau pathology in AD.	Asparagine	158-168	legumain	Homo sapiens	75-79
34917801-5	2021	delta-secretase, also known as asparagine endopeptidase (AEP) or legumain (LGMN), is a lysosomal cysteine protease that cleaves peptide bonds C-terminally to asparagine residues in both amyloid precursor protein (APP) and tau, mediating the amyloid-beta and tau pathology in AD.	Asparagine	158-168	microtubule associated protein tau	Homo sapiens	222-225
34917801-5	2021	delta-secretase, also known as asparagine endopeptidase (AEP) or legumain (LGMN), is a lysosomal cysteine protease that cleaves peptide bonds C-terminally to asparagine residues in both amyloid precursor protein (APP) and tau, mediating the amyloid-beta and tau pathology in AD.	Asparagine	158-168	amyloid beta precursor protein	Homo sapiens	241-253
34917801-5	2021	delta-secretase, also known as asparagine endopeptidase (AEP) or legumain (LGMN), is a lysosomal cysteine protease that cleaves peptide bonds C-terminally to asparagine residues in both amyloid precursor protein (APP) and tau, mediating the amyloid-beta and tau pathology in AD.	Asparagine	158-168	microtubule associated protein tau	Homo sapiens	258-261
34784468-1	2021	Hindered rotation about an sp2 C-N bond is known to occur in arginine (Arg), asparagine (Asn), and glutamine (Gln) side chains of proteins.	Asparagine	89-92	Sp2 transcription factor	Homo sapiens	27-30
34829099-5	2021	The purified GmASNase had the highest specific activity of 486.65 IU mg-1 at pH 9.0 and 50  C. In addition, GmASNase possessed superior properties in terms of stability at a wide pH range of 5.0-11.0 and activity at temperatures below 40  C. Moreover, GmASNase displayed high substrate specificity towards L-asparagine with Km, kcat, and kcat/Km values of 6.025 mM, 11,864.71 min-1 and 1969.25 mM-1min-1, respectively.	Asparagine	306-318	Mix1 homeobox-like 1 (Xenopus laevis)	Mus musculus	394-403
34783057-7	2022	Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2.	Asparagine	118-121	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	81-86
34783057-7	2022	Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2.	Asparagine	118-121	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	208-213
34783057-7	2022	Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2.	Asparagine	118-121	angiotensin converting enzyme 2	Homo sapiens	242-246
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Asparagine	176-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-229
34766381-7	2022	We also discovered that the PHD of UHRF2 contains a distinct asparagine in the H3R2 binding pocket that lowers the binding affinity of the PHD by reducing a potential electrostatic interaction with the H3 tail.	Asparagine	61-71	ubiquitin like with PHD and ring finger domains 2	Homo sapiens	35-40
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Asparagine	176-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
34728685-1	2021	L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries.	Asparagine	68-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
34731213-7	2021	Amino acids arginine, tyrosine, glutamic acid, tryptophan and asparagine also showed moderate COX-1 and COX-2 inhibition at the same concentration.	Asparagine	62-72	cytochrome c oxidase subunit I	Petromyzon marinus	94-99
34731213-7	2021	Amino acids arginine, tyrosine, glutamic acid, tryptophan and asparagine also showed moderate COX-1 and COX-2 inhibition at the same concentration.	Asparagine	62-72	cytochrome c oxidase subunit II	Petromyzon marinus	104-109
34728685-1	2021	L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries.	Asparagine	68-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
34707294-4	2021	The transmembrane channel and Na+ binding are disrupted in DISP1-NNN, a variant with asparagine substitutions for three intramembrane aspartate residues that each coordinate and neutralize the charge of one of the three Na+ ions.	Asparagine	85-95	dispatched RND transporter family member 1	Mus musculus	59-64
34536947-6	2021	The level and duration of exposure were based on the pharmacokinetic profile of the drug and the assumption that trough asparaginase activity levels of >=100 IU/L should be achieved for complete l-asparagine depletion.	Asparagine	195-207	asparaginase	Homo sapiens	120-132
34988176-6	2021	Mass spectrometry was conducted to identify the glycosylation sites of SSTR2, and immunofluorescent staining was carried out to examine the localization of wild-type and asparagine 9 (N9)Q-mutant SSTR2.	Asparagine	170-180	somatostatin receptor 2	Rattus norvegicus	196-201
34403810-0	2021	eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.	Asparagine	73-83	eukaryotic translation initiation factor 4B	Homo sapiens	0-5
34241577-1	2021	The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr.	Asparagine	155-158	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	15-44
34241577-1	2021	The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr.	Asparagine	155-158	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	46-49
34647520-0	2021	SLC1A5 provides glutamine and asparagine necessary for bone development in mice.	Asparagine	30-40	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	0-6
34647520-5	2021	SLC1A5 provides both glutamine and asparagine which are essential for osteoblast differentiation.	Asparagine	35-45	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	0-6
34647520-7	2021	Thus, osteoblasts depend on Slc1a5 to provide glutamine and asparagine, which are subsequently used to produce non-essential amino acids and support osteoblast differentiation and bone development.	Asparagine	60-70	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	28-34
34900242-6	2021	The best interacting sites of galactomannan included ASN-437, SER 373, TRP-436, ASN-343, and ALA 344 with a mean binding energy of -7.4 kcal/mol; and the best interacting sites of betulinic acid were ASN-437, SER 373, TRP-436, PHE 342, ARG 509, and ALA 344 that strongly interacted with the S-protein (DeltaG = -8.1 kcal/mol).	Asparagine	53-56	vitronectin	Homo sapiens	291-300
34900242-6	2021	The best interacting sites of galactomannan included ASN-437, SER 373, TRP-436, ASN-343, and ALA 344 with a mean binding energy of -7.4 kcal/mol; and the best interacting sites of betulinic acid were ASN-437, SER 373, TRP-436, PHE 342, ARG 509, and ALA 344 that strongly interacted with the S-protein (DeltaG = -8.1 kcal/mol).	Asparagine	80-83	vitronectin	Homo sapiens	291-300
34900242-6	2021	The best interacting sites of galactomannan included ASN-437, SER 373, TRP-436, ASN-343, and ALA 344 with a mean binding energy of -7.4 kcal/mol; and the best interacting sites of betulinic acid were ASN-437, SER 373, TRP-436, PHE 342, ARG 509, and ALA 344 that strongly interacted with the S-protein (DeltaG = -8.1 kcal/mol).	Asparagine	200-203	vitronectin	Homo sapiens	291-300
34403810-6	2021	Interestingly, eIF4B supported cellular proliferation under asparagine-limited conditions, possibly through the eIF4B-ATF4 pathway.	Asparagine	60-70	eukaryotic translation initiation factor 4B	Homo sapiens	15-20
34403810-6	2021	Interestingly, eIF4B supported cellular proliferation under asparagine-limited conditions, possibly through the eIF4B-ATF4 pathway.	Asparagine	60-70	eukaryotic translation initiation factor 4B	Homo sapiens	112-117
34403810-6	2021	Interestingly, eIF4B supported cellular proliferation under asparagine-limited conditions, possibly through the eIF4B-ATF4 pathway.	Asparagine	60-70	activating transcription factor 4	Homo sapiens	118-122
34605855-4	2022	The gene encodes SNAT3, a sodium-coupled neutral amino acid transporter and a principal transporter of the amino acids asparagine, histidine, and glutamine, the latter being the precursor for the neurotransmitters GABA and glutamate.	Asparagine	119-129	solute carrier family 38 member 3	Homo sapiens	17-22
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Asparagine	114-124	aspartate beta-hydroxylase	Homo sapiens	0-4
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Asparagine	114-124	epidermal growth factor	Homo sapiens	18-46
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Asparagine	114-124	epidermal growth factor	Homo sapiens	48-51
34396662-3	2021	Using Asn(OH)-mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase 2 (MMP2) inhibitors displaying the hydroxamic acid moiety of Asn(OH) as the key pharmacophore.	Asparagine	6-9	matrix metallopeptidase 2	Homo sapiens	71-97
34396662-3	2021	Using Asn(OH)-mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase 2 (MMP2) inhibitors displaying the hydroxamic acid moiety of Asn(OH) as the key pharmacophore.	Asparagine	6-9	matrix metallopeptidase 2	Homo sapiens	99-103
34396662-3	2021	Using Asn(OH)-mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase 2 (MMP2) inhibitors displaying the hydroxamic acid moiety of Asn(OH) as the key pharmacophore.	Asparagine	157-160	matrix metallopeptidase 2	Homo sapiens	71-97
34396662-3	2021	Using Asn(OH)-mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase 2 (MMP2) inhibitors displaying the hydroxamic acid moiety of Asn(OH) as the key pharmacophore.	Asparagine	157-160	matrix metallopeptidase 2	Homo sapiens	99-103
34562451-4	2021	Individual and combinatory site-directed mutagenesis of the glycosylated asparagine residues indicated that glycosylation of the SP domain is critical for TMPRSS13 autoactivation and catalytic activity towards one of its protein substrates, the prostasin zymogen.	Asparagine	73-83	transmembrane serine protease 13	Homo sapiens	155-163
34246800-7	2021	CPV variants were typed as either CPV-2a, CPV-2b, or CPV-2c on account of amino acid Asn, Asp, or Glu residue, respectively, at VP2 position 426.	Asparagine	85-88	VP2	Canine parvovirus	128-131
34499924-4	2021	Here we studied asparagine deamidation of the spike protein, a spontaneous event that leads to the appearance of aspartic and isoaspartic residues, which affect both the protein backbone and its charge.	Asparagine	16-26	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34562451-4	2021	Individual and combinatory site-directed mutagenesis of the glycosylated asparagine residues indicated that glycosylation of the SP domain is critical for TMPRSS13 autoactivation and catalytic activity towards one of its protein substrates, the prostasin zymogen.	Asparagine	73-83	serine protease 8	Homo sapiens	245-254
34552110-5	2021	Specifically, Tyr and Asn have higher occurrence rates on the Receptor Binding Domain (RBD) and in the overall sequence of spike proteins of Betacoronavirus, whereas His and Arg have lower occurrence rates.	Asparagine	22-25	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	123-128
34455356-4	2021	Four recombinant viruses substituting the asparagine (N) residues at N130, N175, N207 or N130/N175/N207 of NS1 with alanine (A) residues were generated using rDTMUV-i, an infectious cDNA clone of the DTMUV CQW1 strain.	Asparagine	42-52	influenza virus NS1A binding protein	Homo sapiens	107-110
34526446-3	2022	In this study, we substituted threonine of the ATP binding motif in the KIF9 motor domain to asparagine (T100N) in mice using the CRISPR/Cas9 system, which is known to impair kinesin motor activity.	Asparagine	93-103	kinesin family member 9	Mus musculus	72-76
34153338-5	2021	Notably, mutation of 103 threonine on flagellin into asparagine resulted in a potent MRC candidate (Fd-T103N) displaying 1.28-fold increment of interactions with TLR5.	Asparagine	53-63	toll-like receptor 5	Mus musculus	162-166
34489534-3	2021	Here we show that N-linked glycosylation of two highly conserved asparagine residues in the "cap" region of mechanosensitive Piezo1 channels are necessary for the mature protein to reach the plasma membrane.	Asparagine	65-75	piezo type mechanosensitive ion channel component 1	Homo sapiens	125-131
34489534-4	2021	Both mutation of these asparagines (N2294Q/N2331Q) and treatment with an enzyme that hydrolyses N-linked oligosaccharides (PNGaseF) eliminates the fully glycosylated mature Piezo1 protein.	Asparagine	23-34	piezo type mechanosensitive ion channel component 1	Homo sapiens	173-179
34379416-4	2021	Yeast PDI (yPDI) from Saccharomyces cerevisiae is glycosylated at asparagine side chains and the knowledge of its five modified sites enables a realistic computational modeling.	Asparagine	66-76	protein disulfide isomerase family A member 2	Homo sapiens	6-9
34591433-8	2021	The frequency of the FSHR and the ESR1 genotypes combinations - 307Thr/Thr+680Asn/Asn+351AG+397TC was significantly decreased in patients with mastopathy.	Asparagine	82-85	estrogen receptor 1	Homo sapiens	34-38
34502039-9	2021	Overall, we describe histone tail recognition by ATAD2 BRD and illustrate that one acetyllysine group is primarily engaged by the conserved asparagine (N1064), the "RVF" shelf residues, and the flexible ZA loop.	Asparagine	140-150	ATPase family AAA domain containing 2	Homo sapiens	49-54
34283245-4	2021	HAAH is suspected to play an important role in NOTCH signaling via selective hydroxylation of aspartic acid and asparagine residues of epidermal growth factor (EGF)-like domains.	Asparagine	112-122	aspartate beta-hydroxylase	Homo sapiens	0-4
34283245-4	2021	HAAH is suspected to play an important role in NOTCH signaling via selective hydroxylation of aspartic acid and asparagine residues of epidermal growth factor (EGF)-like domains.	Asparagine	112-122	epidermal growth factor	Homo sapiens	135-158
34354228-1	2021	Oligosaccharyltransferase (OST) catalyzes oligosaccharide transfer to the Asn residue in the N-glycosylation sequon, Asn-X-Ser/Thr, where Pro is strictly excluded at position X.	Asparagine	74-77	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
34354228-1	2021	Oligosaccharyltransferase (OST) catalyzes oligosaccharide transfer to the Asn residue in the N-glycosylation sequon, Asn-X-Ser/Thr, where Pro is strictly excluded at position X.	Asparagine	74-77	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
34354242-3	2021	Here we describe the identification of toxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q).	Asparagine	184-187	islet amyloid polypeptide	Homo sapiens	153-157
34190541-9	2021	His-to-Asn and Asn-to-His mutations in the psychrophilic and mesophilic HBDH active sites, respectively, swap the single active-site position where these orthologues diverge.	Asparagine	7-10	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	72-76
34349034-7	2021	Here, we demonstrate that GAS-mediated asparagine induction and release occur through the PERK-eIF2alpha-ATF4 branch of the unfolded protein response.	Asparagine	39-49	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	90-94
34349034-8	2021	Inhibitors of PERK or integrated stress response (ISR) blocked the formation and release of asparagine by infected mammalian cells, and exogenously added asparagine overcame this inhibition.	Asparagine	92-102	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	14-18
34321660-7	2021	Two amino acids-leucine 642 on GluN2A (homologous to leucine 643 on GluN2B) and asparagine 616 on GluN1-were identified as key residues that form hydrophobic and hydrogen-bond interactions with ketamine, and mutations at these residues reduced the potency of ketamine in blocking NMDA receptor channel activity.	Asparagine	80-90	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	98-103
34267184-2	2021	Unfortunately, resistance occurs and has been linked to expression of the enzyme asparagine synthetase (ASNS), which generates asparagine from intracellular sources.	Asparagine	127-137	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	81-102
34267184-2	2021	Unfortunately, resistance occurs and has been linked to expression of the enzyme asparagine synthetase (ASNS), which generates asparagine from intracellular sources.	Asparagine	127-137	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	104-108
34190541-9	2021	His-to-Asn and Asn-to-His mutations in the psychrophilic and mesophilic HBDH active sites, respectively, swap the single active-site position where these orthologues diverge.	Asparagine	15-18	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	72-76
34190541-10	2021	At 5  C, the His-to-Asn mutation in psychrophilic HBDH decreases Dkcat to 3.1, suggesting a decrease in transition-state symmetry, while the His-to-Asn mutation in mesophilic HBDH increases Dkcat to 4.4, indicating an increase in transition-state symmetry.	Asparagine	148-151	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	175-179
34247201-0	2021	Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway.	Asparagine	85-95	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
34249720-1	2021	Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia.	Asparagine	75-87	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-45
34137579-1	2021	Here we show that an NH-pi interaction between a highly conserved Asn and a nearby Trp stabilizes the WW domain of the human protein Pin1.	Asparagine	66-69	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	133-137
34281196-10	2021	Metabolic profiling revealed a reduction of several defense-related primary and secondary metabolites, such as asparagine and glucosinolates in the Arabidopsis mfdx1-1 mutant when compared to Col-0.	Asparagine	111-121	mitochondrial ferredoxin 1	Arabidopsis thaliana	160-167
34249720-1	2021	Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia.	Asparagine	89-92	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-45
34093861-9	2021	Finally, we confirmed that the level of core-fucosylation on FOLR1 especially at the glycosite Asn-201 positively regulated the cellular uptake capacity of folates, and enhanced uptake of folates could promote the EMT of HCC cells.	Asparagine	95-98	folate receptor alpha	Homo sapiens	61-66
34096924-2	2021	The immunity protein of colicin E3 (Im3) and the immunity protein of bacteriocin (Im-Bac) were identified from prominent b- and/or y-type fragment ions generated by the polypeptide backbone cleavage (PBC) on the C-terminal side of aspartic acid, glutamic acid, and asparagine residues by the aspartic acid effect fragmentation mechanism.	Asparagine	265-275	colicin E1 protein	Escherichia coli	69-80
34076169-1	2021	L-Asparaginase catalysing the breakdown of L-Asparagine to L-Aspartate and ammonia is an enzyme of therapeutic importance in the treatment of cancer, especially the lymphomas and leukaemia.	Asparagine	43-55	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
34490059-7	2021	According to this model, their replacement (perhaps with asparagine) would remove the pH-dependent destabilisation of locked spike trimer conformations, and increase their recovery at neutral pH.	Asparagine	57-67	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	125-130
35500441-0	2022	In vitro mannosidase activity of EDEM3 against asparagine-linked oligomannose-type glycans.	Asparagine	47-57	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	33-38
35257867-8	2022	Deep sequencing analysis revealed that the Mot3p of the F118 strain features a unique insertion and deletion of nucleotides that encode glutamine or asparagine residues, particularly in N-terminal domain, as determined by comparison to the Mot3p sequence from the S288c strain, which was employed as a control strain.	Asparagine	149-159	Mot3p	Saccharomyces cerevisiae S288C	43-48
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Asparagine	51-61	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	30-35
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Asparagine	51-61	thioredoxin domain containing 5	Homo sapiens	189-194
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Asparagine	51-61	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	223-228
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	55-58	selectin L	Homo sapiens	209-214
35459935-5	2022	The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.	Asparagine	62-66	nicotinamide phosphoribosyltransferase	Homo sapiens	87-92
35381197-6	2022	Functionally, filamentous GLS1-dependent glutamine scarcity leads to inadequate synthesis of asparagine and mitogenome-encoded proteins, resulting in ROS-induced apoptosis that can be rescued by asparagine supplementation.	Asparagine	93-103	glutaminase	Homo sapiens	26-30
35381197-6	2022	Functionally, filamentous GLS1-dependent glutamine scarcity leads to inadequate synthesis of asparagine and mitogenome-encoded proteins, resulting in ROS-induced apoptosis that can be rescued by asparagine supplementation.	Asparagine	195-205	glutaminase	Homo sapiens	26-30
35554494-4	2022	Genetic complementation experiments in budding yeast demonstrate that the conserved aspartate or its analogous asparagine (N) residue in yeast TAF7 is essential for cell viability and thus its mutation to glycine is lethal.	Asparagine	111-121	TATA-binding protein-associated factor TAF7	Saccharomyces cerevisiae S288C	143-147
35536554-3	2022	A well-known glycoprotein biomarker is alpha-fetoprotein (AFP), a surveillance biomarker for hepatocellular carcinoma (HCC) that contains a glycosylation site at asparagine 251.	Asparagine	162-172	alpha fetoprotein	Homo sapiens	39-56
35536554-3	2022	A well-known glycoprotein biomarker is alpha-fetoprotein (AFP), a surveillance biomarker for hepatocellular carcinoma (HCC) that contains a glycosylation site at asparagine 251.	Asparagine	162-172	alpha fetoprotein	Homo sapiens	58-61
35381197-0	2022	Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.	Asparagine	92-102	glutaminase	Homo sapiens	12-16
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	55-58	selectin L	Homo sapiens	216-221
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	65-68	selectin L	Homo sapiens	209-214
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	65-68	selectin L	Homo sapiens	216-221
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	71-74	selectin L	Homo sapiens	209-214
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	71-74	selectin L	Homo sapiens	216-221
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	201-204	selectin L	Homo sapiens	209-214
35533300-5	2022	Our results showed that the biological activity of the Asn-8 and Asn-8/Asn-18 mutants was significantly reduced, similar to Met-8 sulfoxide and Met-8/Met-18 sulfoxide analogues, while the functions of Asn-18, Leu-8, Leu-8/Leu-18 mutants, or Met-18 sulfoxide analogues were similar to wild-type PTH.	Asparagine	201-204	selectin L	Homo sapiens	216-221
35537551-3	2022	ASPP2 is reported to undergo a single FIH catalysed hydroxylation at Asn-986.	Asparagine	69-72	tumor protein p53 binding protein 2	Homo sapiens	0-5
35615519-9	2022	Molecular docking suggested the hydrogen bond between the pCA carboxyl group and Elongation factor Tu Asn-64 might contribute to deamidation.	Asparagine	102-105	elongation factor Tu	Cronobacter sakazakii	81-101
35377450-4	2022	This single nucleotide deletion not only changes lysine 967 (K) into asparagine (N) but also causes a premature stop codon, which leads to deletion of 968-976 residues from the end of the C-tail region of the SYCP1 protein.	Asparagine	69-79	synaptonemal complex protein 1	Homo sapiens	209-214
35563467-2	2022	Previously, we characterized the appearance of a complex asparagine-linked glycosylated form of lysosome-associated membrane protein 1 (LAMP1) in the cerebellum of Npc1-/- mice.	Asparagine	57-67	lysosomal-associated membrane protein 1	Mus musculus	96-134
35563467-2	2022	Previously, we characterized the appearance of a complex asparagine-linked glycosylated form of lysosome-associated membrane protein 1 (LAMP1) in the cerebellum of Npc1-/- mice.	Asparagine	57-67	lysosomal-associated membrane protein 1	Mus musculus	136-141
35563467-2	2022	Previously, we characterized the appearance of a complex asparagine-linked glycosylated form of lysosome-associated membrane protein 1 (LAMP1) in the cerebellum of Npc1-/- mice.	Asparagine	57-67	NPC intracellular cholesterol transporter 1	Mus musculus	164-168
35491708-13	2022	HighlightsThe dimeric NS1 protein structure was modeled and glycosylated at ASN130 and ASN 207 with Oligo-mannose.The minimized structure was used for molecular docking studies with andrographolide and its derivatives.The Lys14 residue is well interfered by all compounds but based on molecular dynamics and binding affinity studies, neo-andrographolide compound has the promising potential to inhibit the activity of the NS1.Communicated by Ramaswamy H. Sarma.	Asparagine	87-90	influenza virus NS1A binding protein	Homo sapiens	22-25
35323927-13	2022	Of the NEAA, amide AA (Gln and Asn) caused the release of CCK, while Glu and Arg increased the release of GLP-1 from ileum.	Asparagine	31-34	cholecystokinin	Sus scrofa	58-61
35563467-4	2022	To test the importance of complex asparagine-linked glycosylation in NPC1 pathology, we generated NPC1 knock-out mice deficient in MGAT5, a key Golgi-resident glycosyl transferase involved in complex asparagine-linked glycosylation.	Asparagine	34-44	mannoside acetylglucosaminyltransferase 5	Mus musculus	131-136
35563467-4	2022	To test the importance of complex asparagine-linked glycosylation in NPC1 pathology, we generated NPC1 knock-out mice deficient in MGAT5, a key Golgi-resident glycosyl transferase involved in complex asparagine-linked glycosylation.	Asparagine	200-210	mannoside acetylglucosaminyltransferase 5	Mus musculus	131-136
35129766-3	2022	The synthesis of Asn occurs through the enzyme asparagine synthetase (ASNS).	Asparagine	17-20	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	47-68
35129766-3	2022	The synthesis of Asn occurs through the enzyme asparagine synthetase (ASNS).	Asparagine	17-20	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	70-74
35129766-10	2022	RESULTS: An RNA editing event (c.3101 A > G) at UPF1 transcripts resulting in an Asparagine (p.1034) changed to a Serine is found in one primary PDAC patient.	Asparagine	81-91	UPF1 RNA helicase and ATPase	Homo sapiens	48-52
34981854-4	2022	We altered glycosylation through enzymatic deglycosylation, small molecule inhibition of glycosyltransferases, or through site-directed mutagenesis of selected asparagine residues in FGFR4.	Asparagine	160-170	fibroblast growth factor receptor 4	Homo sapiens	183-188
35347248-12	2022	We demonstrated that DHA directly bound to Asn 1529 and Thr 1528 of DNMT1 with a Kd value of 8.18 muM.	Asparagine	43-46	DNA methyltransferase (cytosine-5) 1	Mus musculus	68-73
35360108-12	2022	Interestingly, certain butyrate-producing bacteria increase significantly after IL-2 treatment, like Lachnospiraceae, Pseudobutyrivibrio, etc., and are associated with a rise in L-Asparagine and L-Leucine.	Asparagine	178-190	interleukin 2	Homo sapiens	80-84
35137060-4	2022	In silico analyses indicated that CaCIPK13 is a typical CIPK family member with a conserved NAF motif, which consists of the amino acids asparagine, alanine, and phenylalanine.	Asparagine	137-147	calcineurin B-like interacting protein kinase	Solanum lycopersicum	56-60
34966089-6	2022	The connection relies on N-glycans attached to glycosylated asparagines of alpha-ENaC.	Asparagine	60-71	sodium channel epithelial 1 subunit alpha	Homo sapiens	75-85
34981854-11	2022	Mutation of Asn-112, Asn-258, Asn-290, or Asn-311 to glutamine modestly reduced apoptosis resistance, while mutation of Asn-322 or simultaneous mutation of the other four asparagine residues caused a loss of cytoprotection by FGFR4.	Asparagine	12-15	fibroblast growth factor receptor 4	Homo sapiens	226-231
35217650-5	2022	Mechanistically, we found that AEP directly cleaved the actin-binding protein cofilin-1 after the asparagine 138 (N138) site.	Asparagine	98-108	legumain	Mus musculus	31-34
34981854-13	2022	Finally, mutation of Asn-112 caused a partial localization of FGFR4 to the Golgi.	Asparagine	21-24	fibroblast growth factor receptor 4	Homo sapiens	62-67
35217650-5	2022	Mechanistically, we found that AEP directly cleaved the actin-binding protein cofilin-1 after the asparagine 138 (N138) site.	Asparagine	98-108	cofilin 1, non-muscle	Mus musculus	78-87
35208238-7	2022	Furthermore, in the asparagine synthetase (ASNS)-catalyzed asparagine synthesis pathway, asparagine was associated with substantially poorer OS (HR (95% CI): 6.39 (1.78-22.91)) and RFS (HR (95% CI): 4.36 (1.39-13.68)) for female patients only.	Asparagine	59-69	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	20-41
35209187-6	2022	In particular, GOT1 reacted ~106-fold less efficiently when the side-chain carboxylate of the "physiological" substrates (aspartate and glutamate) was replaced by an amido group (asparagine and glutamine).	Asparagine	179-189	glutamic-oxaloacetic transaminase 1	Homo sapiens	15-19
34996645-6	2022	Comparative analysis showed lactate and fumarate utilization by C. jejuni and C. coli exclusively, whereas ESBL-E. coli rapidly consumed asparagine, glutamine/arginine, lysine, threonine, tryptophan, pyruvate, glycerol, cellobiose, and glucose.	Asparagine	137-147	EsbL	Escherichia coli	107-111
35181908-4	2022	Finally, we suggest that the carbohydrate chain at Asn-39 restricts the activator specificity, as elimination of this glycosylation site increases the activation rate for activation by FIXa and FXa.	Asparagine	51-54	coagulation factor X	Homo sapiens	194-197
35205650-2	2022	Systemic administration of bacterial L-ASNase is successfully used to lower the bioavailability of this non-essential amino acid and to eradicate rapidly proliferating cancer cells with a high demand for exogenous asparagine.	Asparagine	214-224	asparaginase and isoaspartyl peptidase 1	Homo sapiens	37-45
35205650-4	2022	Since these lymphoblasts lack the expression of asparagine synthetase (ASNS), these cells depend on the uptake of extracellular asparagine for survival.	Asparagine	128-138	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	48-69
35205650-4	2022	Since these lymphoblasts lack the expression of asparagine synthetase (ASNS), these cells depend on the uptake of extracellular asparagine for survival.	Asparagine	128-138	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	71-75
35208238-7	2022	Furthermore, in the asparagine synthetase (ASNS)-catalyzed asparagine synthesis pathway, asparagine was associated with substantially poorer OS (HR (95% CI): 6.39 (1.78-22.91)) and RFS (HR (95% CI): 4.36 (1.39-13.68)) for female patients only.	Asparagine	59-69	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	43-47
35208238-7	2022	Furthermore, in the asparagine synthetase (ASNS)-catalyzed asparagine synthesis pathway, asparagine was associated with substantially poorer OS (HR (95% CI): 6.39 (1.78-22.91)) and RFS (HR (95% CI): 4.36 (1.39-13.68)) for female patients only.	Asparagine	89-99	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	20-41
35208238-7	2022	Furthermore, in the asparagine synthetase (ASNS)-catalyzed asparagine synthesis pathway, asparagine was associated with substantially poorer OS (HR (95% CI): 6.39 (1.78-22.91)) and RFS (HR (95% CI): 4.36 (1.39-13.68)) for female patients only.	Asparagine	89-99	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	43-47
35047480-5	2021	Deamidation of light-chain Asn-30 (Lc-Asn-30) was extensive when trastuzumab was stressed free but reduced about 10-fold when the antibody was stressed in complex with HER2.	Asparagine	27-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	168-172
35164193-1	2022	L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection.	Asparagine	154-166	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
35164193-1	2022	L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection.	Asparagine	154-166	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
35491020-4	2022	Complexation of ConA and CD206 with ligands is shown to be energetically caused by electrostatic interactions (E) of the charged residues (Asn, Asp, Arg) with oxygen and hydrogen atoms in carbohydrates; contributions of hydrophobic and van der Waals components is lower.	Asparagine	139-142	mannose receptor C-type 1	Homo sapiens	25-30