PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31594422-5 2020 CSE/CBS inhibitors propargylglycine, beta-cyano-L-alanine, and aminooxyacetic acid blocked brain H2S generation and cerebral vasodilation caused by SFN. 3-cyanoalanine 37-57 cystathionine gamma-lyase Homo sapiens 0-3 6104660-2 1980 The reaction of D-amino acid oxidase [EC 1.4.3.3] (DAO) from porcine kidney with beta-cyano-D-alanine (D-BCNA) was studied. 3-cyanoalanine 81-101 D-amino acid oxidase Homo sapiens 51-54 6104660-11 1980 The aerobic reaction of beta-cyano-L-alanine (L-BCNA) with snake venom L-amino acid oxidase (LAO) produced the same product with an absorption at 285 nm as the reaction of DAO with D-BCNA. 3-cyanoalanine 24-44 interleukin 4 induced 1 Homo sapiens 71-91 6104660-11 1980 The aerobic reaction of beta-cyano-L-alanine (L-BCNA) with snake venom L-amino acid oxidase (LAO) produced the same product with an absorption at 285 nm as the reaction of DAO with D-BCNA. 3-cyanoalanine 24-44 interleukin 4 induced 1 Homo sapiens 93-96 6104660-11 1980 The aerobic reaction of beta-cyano-L-alanine (L-BCNA) with snake venom L-amino acid oxidase (LAO) produced the same product with an absorption at 285 nm as the reaction of DAO with D-BCNA. 3-cyanoalanine 24-44 D-amino acid oxidase Homo sapiens 172-175 33860955-2 2021 Additionally, H2 S is also produced in cytosol and mitochondria by desulfhydration of L-cysteine catalyzed by L-cysteine desulfhydrase (DES1) in the cytosol and from beta-cyanoalanine in mitochondria, in a reaction catalyzed by beta-cyano-Ala synthase C1 (CAS-C1). 3-cyanoalanine 166-183 delta 4-desaturase, sphingolipid 1 Homo sapiens 136-140 30265150-8 2018 ET-1 (10-12-10-8 M) caused an elevation of H2S that was reduced by the CSE inhibitors propargylglycine (PPG) and beta-cyano-l-alanine (BCA). 3-cyanoalanine 113-133 endothelin 1 Homo sapiens 0-4 32581821-5 2020 This relaxation was strongly inhibited by the Rho-kinase inhibitor Y-27632 (10 muM), by the reducing agent DTT or by the inhibitor of soluble guanylate cyclase (sGC) ODQ (10 muM) alone or in combination with the inhibitors of the endogenous synthesis of H2S beta-cyano-L-alanine (5 mM) and amino-oxyacetate (5 mM). 3-cyanoalanine 258-278 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 134-159 32581821-5 2020 This relaxation was strongly inhibited by the Rho-kinase inhibitor Y-27632 (10 muM), by the reducing agent DTT or by the inhibitor of soluble guanylate cyclase (sGC) ODQ (10 muM) alone or in combination with the inhibitors of the endogenous synthesis of H2S beta-cyano-L-alanine (5 mM) and amino-oxyacetate (5 mM). 3-cyanoalanine 258-278 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 161-164 31625777-6 2019 Under anesthesia, CSE inhibition [beta-cyanoalanine (BCA), 30 mg/kg bolus + 5 mg kg-1 min-1 for 20 min iv) rapidly increased mean arterial pressure (MAP) more than saline administration (%Delta: saline -1.4 +- 0.75 vs. BCA 7.1 +- 1.69, P < 0.05) but did not change resistance (MAP/flow) in either the mesenteric or renal circulation. 3-cyanoalanine 34-51 cystathionine gamma-lyase Rattus norvegicus 18-21 31625777-6 2019 Under anesthesia, CSE inhibition [beta-cyanoalanine (BCA), 30 mg/kg bolus + 5 mg kg-1 min-1 for 20 min iv) rapidly increased mean arterial pressure (MAP) more than saline administration (%Delta: saline -1.4 +- 0.75 vs. BCA 7.1 +- 1.69, P < 0.05) but did not change resistance (MAP/flow) in either the mesenteric or renal circulation. 3-cyanoalanine 53-56 cystathionine gamma-lyase Rattus norvegicus 18-21 30265150-8 2018 ET-1 (10-12-10-8 M) caused an elevation of H2S that was reduced by the CSE inhibitors propargylglycine (PPG) and beta-cyano-l-alanine (BCA). 3-cyanoalanine 135-138 endothelin 1 Homo sapiens 0-4 30265150-9 2018 Low doses of ET-1 (10-12-10-11 M) produced vasodilation of pial arterioles that was blocked PPG and BCA, suggesting the importance of H2S influences. 3-cyanoalanine 100-103 endothelin 1 Homo sapiens 13-17 28130342-8 2017 Endothelium-dependent vasodilation to acetylcholine (ACh) was lower in mesenteric arteries from IH rats than in arteries from sham rats, and inhibiting CSE with beta-cyanoalanine diminished ACh-induced vasodilation in arteries from sham but not IH rats but did not affect dilation to the H2S donor NaHS. 3-cyanoalanine 161-178 cystathionine gamma-lyase Rattus norvegicus 152-155 29044685-7 2018 beta-Cyano-l-alanine, a reversible selective CSE inhibitor, prevented CPA-induced nociceptive behaviour, referred hyperalgesia, and, in part, increases in bladder weight. 3-cyanoalanine 0-20 cystathionase (cystathionine gamma-lyase) Mus musculus 45-48 29129814-8 2018 The CSE inhibitor, beta-cyano-l-alanine, prevented the BP/RH and upregulation of Cav3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. 3-cyanoalanine 19-39 cystathionase (cystathionine gamma-lyase) Mus musculus 4-7 29129814-8 2018 The CSE inhibitor, beta-cyano-l-alanine, prevented the BP/RH and upregulation of Cav3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. 3-cyanoalanine 19-39 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 81-87 29129814-8 2018 The CSE inhibitor, beta-cyano-l-alanine, prevented the BP/RH and upregulation of Cav3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. 3-cyanoalanine 19-39 early growth response 1 Mus musculus 89-94 29129814-8 2018 The CSE inhibitor, beta-cyano-l-alanine, prevented the BP/RH and upregulation of Cav3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. 3-cyanoalanine 19-39 ubiquitin specific peptidase 5 (isopeptidase T) Mus musculus 99-103 27150157-5 2016 CSE inhibitors, DL-propargylglycine (PPG) and beta-cyano-L-alanine (BCA), significantly suppressed the proliferation of AGS cells in a concentration-dependent manner. 3-cyanoalanine 46-66 cystathionine gamma-lyase Homo sapiens 0-3 27150157-5 2016 CSE inhibitors, DL-propargylglycine (PPG) and beta-cyano-L-alanine (BCA), significantly suppressed the proliferation of AGS cells in a concentration-dependent manner. 3-cyanoalanine 68-71 cystathionine gamma-lyase Homo sapiens 0-3 25630260-4 2015 Conversely, other CSE antagonists tested, aminooxyacetic acid (AOAA, 100 mum), beta-cyanoalanine (BCA, 500 mum) and hydroxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (BCA increased, AOAA and HA inhibited). 3-cyanoalanine 79-96 cystathionine gamma-lyase Rattus norvegicus 18-21 25630260-4 2015 Conversely, other CSE antagonists tested, aminooxyacetic acid (AOAA, 100 mum), beta-cyanoalanine (BCA, 500 mum) and hydroxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (BCA increased, AOAA and HA inhibited). 3-cyanoalanine 175-178 cystathionine gamma-lyase Rattus norvegicus 18-21 25630260-4 2015 Conversely, other CSE antagonists tested, aminooxyacetic acid (AOAA, 100 mum), beta-cyanoalanine (BCA, 500 mum) and hydroxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (BCA increased, AOAA and HA inhibited). 3-cyanoalanine 175-178 cystathionine gamma-lyase Rattus norvegicus 18-21 24093945-9 2013 CLSS-2 can readily differentiate between H2S production in active CSE and CSE inhibited with beta-cyanoalanine (BCA) in both isolated CSE enzymes (p < 0.005) and in C6 cells (p < 0.005). 3-cyanoalanine 112-115 cystathionine gamma-lyase Homo sapiens 74-77 24093945-9 2013 CLSS-2 can readily differentiate between H2S production in active CSE and CSE inhibited with beta-cyanoalanine (BCA) in both isolated CSE enzymes (p < 0.005) and in C6 cells (p < 0.005). 3-cyanoalanine 112-115 cystathionine gamma-lyase Homo sapiens 74-77 24093945-9 2013 CLSS-2 can readily differentiate between H2S production in active CSE and CSE inhibited with beta-cyanoalanine (BCA) in both isolated CSE enzymes (p < 0.005) and in C6 cells (p < 0.005). 3-cyanoalanine 93-110 cystathionine gamma-lyase Homo sapiens 74-77 22115353-8 2011 As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide. 3-cyanoalanine 216-233 cystathionine beta-synthase Homo sapiens 3-30 24093945-9 2013 CLSS-2 can readily differentiate between H2S production in active CSE and CSE inhibited with beta-cyanoalanine (BCA) in both isolated CSE enzymes (p < 0.005) and in C6 cells (p < 0.005). 3-cyanoalanine 93-110 cystathionine gamma-lyase Homo sapiens 74-77 24093945-9 2013 CLSS-2 can readily differentiate between H2S production in active CSE and CSE inhibited with beta-cyanoalanine (BCA) in both isolated CSE enzymes (p < 0.005) and in C6 cells (p < 0.005). 3-cyanoalanine 112-115 cystathionine gamma-lyase Homo sapiens 66-69 23525712-9 2013 Inhibiting cystathionine gamma-lyase (CSE)-derived H2S with beta-cyano-l-alanine (BCA) also reduced VSMC Ca(2+) spark frequency in mesenteric arteries, as did EC disruption. 3-cyanoalanine 60-80 cystathionine gamma-lyase Rattus norvegicus 11-36 23525712-9 2013 Inhibiting cystathionine gamma-lyase (CSE)-derived H2S with beta-cyano-l-alanine (BCA) also reduced VSMC Ca(2+) spark frequency in mesenteric arteries, as did EC disruption. 3-cyanoalanine 60-80 cystathionine gamma-lyase Rattus norvegicus 38-41 23525712-9 2013 Inhibiting cystathionine gamma-lyase (CSE)-derived H2S with beta-cyano-l-alanine (BCA) also reduced VSMC Ca(2+) spark frequency in mesenteric arteries, as did EC disruption. 3-cyanoalanine 82-85 cystathionine gamma-lyase Rattus norvegicus 11-36 23525712-9 2013 Inhibiting cystathionine gamma-lyase (CSE)-derived H2S with beta-cyano-l-alanine (BCA) also reduced VSMC Ca(2+) spark frequency in mesenteric arteries, as did EC disruption. 3-cyanoalanine 82-85 cystathionine gamma-lyase Rattus norvegicus 38-41 22887971-1 2012 A new type of double prodrug of the antiviral family of bicyclic nucleoside analogues (BCNA) bearing cyclization self-cleavage spacers between the Val-Pro dipeptide sequence as well as the parent compound were synthesized and evaluated with regard to activation by the DPPIV/CD26 enzyme and for their stability in human and bovine serum. 3-cyanoalanine 87-91 dipeptidyl peptidase 4 Homo sapiens 275-279 21596106-6 2011 Systemic administration of dl-propargylglycine and beta-cyanoalanine, irreversible and reversible inhibitors of CSE, respectively, also abolished the established neuropathic hyperalgesia. 3-cyanoalanine 51-68 cystathionine gamma-lyase Rattus norvegicus 112-115 21336541-12 2011 CSE inhibitors DL: -propargylglycine (20 mM) and beta-cyanoalanine (1 mM) caused concentration-dependent contraction of mouse aorta. 3-cyanoalanine 49-66 cystathionase (cystathionine gamma-lyase) Mus musculus 0-3 23488457-8 2013 On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM. 3-cyanoalanine 128-131 cystathionine beta-synthase Homo sapiens 65-68 23488457-12 2013 CONCLUSIONS AND IMPLICATIONS: In conclusion, although PAG, AVG and BCA exhibit selectivity in inhibiting CSE versus CBS, no selective pharmacological CBS inhibitor is currently available. 3-cyanoalanine 67-70 cystathionine beta-synthase Homo sapiens 116-119 22511607-2 2012 In mitochondria, cyanide is a potent inhibitor of the cytochrome c oxidase and is metabolized by the beta-cyanoalanine synthase CYS-C1, catalyzing the conversion of cysteine and cyanide to hydrogen sulfide and beta-cyanoalanine. 3-cyanoalanine 101-118 cysteine synthase C1 Arabidopsis thaliana 128-134 22115353-8 2011 As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide. 3-cyanoalanine 216-233 cystathionine gamma-lyase Homo sapiens 35-60 20546998-5 2010 administration of dl-propargylglycine (PPG) and beta-cyanoalanine, irreversible and reversible CSE inhibitors, respectively, strongly suppressed the neuropathic hyperalgesia/allodynia. 3-cyanoalanine 48-65 cystathionine gamma-lyase Homo sapiens 95-98 19450488-10 2009 hbAP-Phe(CN) therefore provides a successful template for extending these investigations of the interactions of halothane with the model membrane protein via vibrational spectroscopy, using cyano-alanine residues to form the anesthetic binding cavity. 3-cyanoalanine 190-203 prohibitin 2 Homo sapiens 0-4 18786181-4 2009 We reveal that pinA is a NIT4-type nitrilase that catalyses the hydrolysis of beta-cyano-L-alanine, a nitrile common in the plant environment and an intermediate in the cyanide detoxification pathway in plants. 3-cyanoalanine 78-98 nitrilase 4 Arabidopsis thaliana 25-29 18786181-5 2009 In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic acid and ammonia by NIT4. 3-cyanoalanine 34-54 nitrilase 4 Arabidopsis thaliana 121-125 18786181-8 2009 In addition, pinA is shown to complement a NIT4 mutation in Arabidopsis thaliana, enabling plants to grow in concentrations of beta-cyano-L-alanine that would otherwise prove lethal. 3-cyanoalanine 127-147 nitrilase 4 Arabidopsis thaliana 43-47 16781459-5 2006 Moreover, NO production in LPS-stimulated macrophages that are expressing CSE mRNA was significantly reduced by the addition of L-Cys, a substrate for H(2)S, but enhanced by the selective CSE inhibitor beta-cyano-L-alanine but not by the CBS inhibitor aminooxyacetic acid. 3-cyanoalanine 202-222 cystathionine gamma-lyase Homo sapiens 74-77 18182427-4 2007 An additional enzymatic function, turnover of beta-cyanoalanine, is acquired when ZmNIT2 forms heteromers with the homologue ZmNIT1. 3-cyanoalanine 46-63 nitrilase 2 Zea mays 82-88 18182427-4 2007 An additional enzymatic function, turnover of beta-cyanoalanine, is acquired when ZmNIT2 forms heteromers with the homologue ZmNIT1. 3-cyanoalanine 46-63 nitrilase 1 Zea mays 125-131 16718684-9 2006 Lowering endogenous H2S level with, D,L-propargylglycine and beta-cyano-L-alanine, two CSE inhibitors, significantly decreased [Ca2+]i, suggesting that endogenous H2S may have a positive tonic influence on [Ca2+]i homeostasis. 3-cyanoalanine 61-81 cystathionine gamma-lyase Homo sapiens 87-90 16781459-5 2006 Moreover, NO production in LPS-stimulated macrophages that are expressing CSE mRNA was significantly reduced by the addition of L-Cys, a substrate for H(2)S, but enhanced by the selective CSE inhibitor beta-cyano-L-alanine but not by the CBS inhibitor aminooxyacetic acid. 3-cyanoalanine 202-222 cystathionine gamma-lyase Homo sapiens 188-191 16786295-9 2006 The recombinant LaNIT4 enzymes, like Arabidopsis NIT4, hydrolyze cyanoalanine to asparagine and aspartic acid but show a much higher cyanoalanine-hydratase activity. 3-cyanoalanine 65-77 nitrilase 4 Arabidopsis thaliana 18-22 16663772-1 1984 beta-Cyanoalanine synthase, which catalyzes the reaction between cysteine and HCN to form beta-cyanoalanine and H(2)S, was assayed in leaf tissues from cyanogenic (Sorghum bicolor x Sorghum sudanense [sorghum]) and noncyanogenic (Pisum sativum [pea], Zea mays [maize], and Allium porrum [leek]) plants. 3-cyanoalanine 90-107 cysteine synthase Zea mays 0-26