PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 1522070-5 1992 A temperature-sensitive mutant was isolated and found to express a DHPS with a lower specific activity and lower affinities for para-aminobenzoic acid and sulfathiazole. Sulfathiazole 155-168 Dihydropteroate synthase Escherichia coli 67-71 15518878-5 2004 In fact, Salmonella and Escherichia coli strains carrying pRF-1 were found to show strong resistance to sulfathiazole, suggesting that orf1 is a functional gene. Sulfathiazole 104-117 hypothetical protein Escherichia coli 135-139 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 2-15 Dihydropteroate synthase Escherichia coli 26-50 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 2-15 Dihydropteroate synthase Escherichia coli 52-56 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 2-15 dihydropteroate synthase Escherichia coli 185-189 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 146-159 Dihydropteroate synthase Escherichia coli 26-50 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 146-159 Dihydropteroate synthase Escherichia coli 52-56 9449266-1 1998 A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. Sulfathiazole 146-159 dihydropteroate synthase Escherichia coli 185-189 9449266-4 1998 Replacement of the mutant folP alleles with wild-type folP significantly reduced the level of resistance to sulfathiazole but did not abolish it, indicating the presence of an additional mutation(s) that contributes to sulfathiazole resistance in the two strains. Sulfathiazole 108-121 dihydropteroate synthase Escherichia coli 26-30 9449266-4 1998 Replacement of the mutant folP alleles with wild-type folP significantly reduced the level of resistance to sulfathiazole but did not abolish it, indicating the presence of an additional mutation(s) that contributes to sulfathiazole resistance in the two strains. Sulfathiazole 108-121 dihydropteroate synthase Escherichia coli 54-58 9449266-4 1998 Replacement of the mutant folP alleles with wild-type folP significantly reduced the level of resistance to sulfathiazole but did not abolish it, indicating the presence of an additional mutation(s) that contributes to sulfathiazole resistance in the two strains. Sulfathiazole 219-232 dihydropteroate synthase Escherichia coli 26-30 9449266-4 1998 Replacement of the mutant folP alleles with wild-type folP significantly reduced the level of resistance to sulfathiazole but did not abolish it, indicating the presence of an additional mutation(s) that contributes to sulfathiazole resistance in the two strains. Sulfathiazole 219-232 dihydropteroate synthase Escherichia coli 54-58 9449266-5 1998 Transfer of the mutant folP allele to a wild-type background resulted in a strain with only a low level of resistance to sulfathiazole, suggesting that the presence of the resistant DHPS was not in itself sufficient to account for the overall sulfathiazole resistance in these strains of E. coli. Sulfathiazole 121-134 dihydropteroate synthase Escherichia coli 23-27 9449266-5 1998 Transfer of the mutant folP allele to a wild-type background resulted in a strain with only a low level of resistance to sulfathiazole, suggesting that the presence of the resistant DHPS was not in itself sufficient to account for the overall sulfathiazole resistance in these strains of E. coli. Sulfathiazole 243-256 dihydropteroate synthase Escherichia coli 23-27 9650994-6 1998 Although the specific activity of DHPS in crude extracts was not significantly different from the wild type, the amino acid substitution resulted in an enzyme with a tenfold increase in the Km for p-aminobenzoate, and a 100-fold increase in the Ki for sulfathiazole. Sulfathiazole 252-265 dihydropteroate synthetase Escherichia coli 34-38 1413882-16 1992 N4-lactose conjugates of sulphapyridine, sulphamerazine, sulphathiazole, sulphadimethoxine and sulphaquinoxaline were present in the milk from cows orally dosed with these five sulphonamide drugs. Sulfathiazole 57-71 Weaning weight-maternal milk Bos taurus 133-137 32529657-1 2020 In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their chemical structures were characterized by Fourier transform infrared, 1 H-NMR (nuclear magnetic resonance), 13 C-NMR, and high-resolution mass spectroscopy methods. Sulfathiazole 78-91 syndecan binding protein Homo sapiens 102-108 6500037-1 1984 In experimental toxic hepatitis induced by injection of CCl4 into rats, the rat blood and urine content of acetylated sulfamonomethoxine diminishes, the acetylation of sulfamonomethoxine and norsulfazole in an isolated stomach of the rat reduces, and acetylation of sulfamonomethoxine is inhibited by rat liver and small intestine homogenates. Sulfathiazole 191-203 C-C motif chemokine ligand 4 Rattus norvegicus 56-60 1255431-3 1976 In contrast, the binding of sulfathiazole was significantly greater in the plasma than in solutions of fraction V bovine serum albumin. Sulfathiazole 28-41 albumin Bos taurus 121-134 33168252-6 2021 The fluorescent probe allowed the STZ concentration to be accurately determined with a low detection limit of 5.5 ng mL-1 in two wide linear ranges of 0.008-10 mug mL-1 and 10-45 mug mL-1. Sulfathiazole 34-37 L1 cell adhesion molecule Mus musculus 117-121 33168252-6 2021 The fluorescent probe allowed the STZ concentration to be accurately determined with a low detection limit of 5.5 ng mL-1 in two wide linear ranges of 0.008-10 mug mL-1 and 10-45 mug mL-1. Sulfathiazole 34-37 L1 cell adhesion molecule Mus musculus 164-178 33168252-6 2021 The fluorescent probe allowed the STZ concentration to be accurately determined with a low detection limit of 5.5 ng mL-1 in two wide linear ranges of 0.008-10 mug mL-1 and 10-45 mug mL-1. Sulfathiazole 34-37 L1 cell adhesion molecule Mus musculus 164-168 34119615-3 2021 Especially, imidazole derivative 5f could strongly suppressed the growth of MRSA (MIC = 4 mug/mL), which was 2-fold and 16-fold more potent than the positive control sulfathiazole and norfloxacin. Sulfathiazole 166-179 CD44 molecule (Indian blood group) Homo sapiens 82-89 33792624-7 2021 Connectivity map have identified five drugs (levobunolol, NU-1025, quipazine, anisomycin and sulfathiazole) for CAHM targeted therapy in THCA. Sulfathiazole 93-106 colon adenocarcinoma hypermethylated Homo sapiens 112-116 32529657-1 2020 In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their chemical structures were characterized by Fourier transform infrared, 1 H-NMR (nuclear magnetic resonance), 13 C-NMR, and high-resolution mass spectroscopy methods. Sulfathiazole 163-176 syndecan binding protein Homo sapiens 102-108 31185432-4 2019 All pharmaceuticals except acetylsalicylic acid and sulfathiazole were found in PS1, PS2, and PS3 samples, whereas acetylsalicylic acid, carbamazepine, sulfamethazine, and sulfamethoxazole were found in PS4, most of the pharmaceuticals were not present in PS5. Sulfathiazole 52-65 taste 2 receptor member 62 pseudogene Homo sapiens 80-83 31344571-5 2019 For instance, degradation rates of STZ increased from 0.3 x 10-3 to 19.5 x 10-3 min-1 as the temperature was increased from 30 to 60 C. Under the same experimental conditions, the degradation rates of SAs followed the order of SIX > SMX STZ > SMT, which was in accordance with decay rates of their R-NH2 moieties. Sulfathiazole 35-38 CD59 molecule (CD59 blood group) Homo sapiens 80-85 31185432-4 2019 All pharmaceuticals except acetylsalicylic acid and sulfathiazole were found in PS1, PS2, and PS3 samples, whereas acetylsalicylic acid, carbamazepine, sulfamethazine, and sulfamethoxazole were found in PS4, most of the pharmaceuticals were not present in PS5. Sulfathiazole 52-65 taste 2 receptor member 64 pseudogene Homo sapiens 85-88 31185432-4 2019 All pharmaceuticals except acetylsalicylic acid and sulfathiazole were found in PS1, PS2, and PS3 samples, whereas acetylsalicylic acid, carbamazepine, sulfamethazine, and sulfamethoxazole were found in PS4, most of the pharmaceuticals were not present in PS5. Sulfathiazole 52-65 taste 2 receptor member 6 pseudogene Homo sapiens 94-97 28224909-5 2017 Under the optimum conditions, the developed method provided a wide linear range from 0.20 to 100.0 mug L-1 for sulfadiazine, sulfathiazole and sulfamerazine; and from 0.10 to 100 mug L-1 for sulfamethazine, sulfamonomethoxine and sulfadimethoxine. Sulfathiazole 125-138 immunoglobulin kappa variable 1-16 Homo sapiens 103-106 28979301-5 2017 The relative standard deviation for five measurements of 100 ng mL-1 of STZ was 5.8 %. Sulfathiazole 72-75 L1 cell adhesion molecule Mus musculus 64-68 23499238-1 2013 Fifteen novel sulfathiazole-related compounds were designed as PTP1B inhibitors based on a previously reported allosteric inhibitor (1) of PTP1B. Sulfathiazole 14-27 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 63-68 27348196-7 2016 In total, 11, 12, and 15 DBP structures were proposed for sulfamethoxazole, sulfathiazole, and sulfadimethoxine, respectively. Sulfathiazole 76-89 D-box binding PAR bZIP transcription factor Homo sapiens 25-28 25106475-6 2014 The detection and quantification limits of sulfathiazole were calculated as 2.52 and 8.40 muM in the presence of trypsin, respectively. Sulfathiazole 43-56 latexin Homo sapiens 90-93 25106475-7 2014 The relative standard deviation (RSD) was 4.086% for determinations (n = 7) of a sulfathiazole solution with the concentration of 7.54 muM. Sulfathiazole 81-94 latexin Homo sapiens 135-138 23499238-1 2013 Fifteen novel sulfathiazole-related compounds were designed as PTP1B inhibitors based on a previously reported allosteric inhibitor (1) of PTP1B. Sulfathiazole 14-27 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 139-144 23450781-8 2013 Sulphathiazole treatment was followed by higher expression of p53/DRAM and downregulation of Akt/mTOR pathway resulting in death autophagy. Sulfathiazole 0-14 DNA damage regulated autophagy modulator 1 Homo sapiens 66-70 23450781-8 2013 Sulphathiazole treatment was followed by higher expression of p53/DRAM and downregulation of Akt/mTOR pathway resulting in death autophagy. Sulfathiazole 0-14 tumor protein p53 Homo sapiens 62-65 23450781-8 2013 Sulphathiazole treatment was followed by higher expression of p53/DRAM and downregulation of Akt/mTOR pathway resulting in death autophagy. Sulfathiazole 0-14 AKT serine/threonine kinase 1 Homo sapiens 93-96 23450781-8 2013 Sulphathiazole treatment was followed by higher expression of p53/DRAM and downregulation of Akt/mTOR pathway resulting in death autophagy. Sulfathiazole 0-14 mechanistic target of rapamycin kinase Homo sapiens 97-101 21190426-4 2011 The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC(50) values of 1.0, 2.6, and 1.5 muM, respectively. Sulfathiazole 28-41 heat shock protein 90 alpha family class A member 1 Homo sapiens 105-110 21190426-4 2011 The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC(50) values of 1.0, 2.6, and 1.5 muM, respectively. Sulfathiazole 28-41 latexin Homo sapiens 151-154