PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	36-39
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	131-134
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	131-134
26619345-6	2015	Here we report that the inhibition of class1 phosphoinositide 3-kinases isoform PI3Kbeta using the selective antagonist PI828 is alone sufficient to produce upregulation and enhance both nicotine and choline HC3-sensitive mediated upregulation.	Hemicholinium 3	208-211	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	80-88
26278668-8	2015	Hemicholinium-3, in low concentrations an inhibitor of the high-affinity choline transporter-1 (CHT1), completely abrogated the eserine effects when applied in high concentrations (10(-4)M) pointing towards an involvement of low-affinity choline transporters.	Hemicholinium 3	0-15	solute carrier family 5 (choline transporter), member 7	Mus musculus	59-94
26278668-8	2015	Hemicholinium-3, in low concentrations an inhibitor of the high-affinity choline transporter-1 (CHT1), completely abrogated the eserine effects when applied in high concentrations (10(-4)M) pointing towards an involvement of low-affinity choline transporters.	Hemicholinium 3	0-15	solute carrier family 5 (choline transporter), member 7	Mus musculus	96-100
22483272-2	2012	The solute carrier 44A1 (SLC44A1), also referred to as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter with an intermediate affinity for choline; this transport is Na(+)-independent and sensitive to inhibition by the drug hemicholinium-3.	Hemicholinium 3	262-275	solute carrier family 44 member 1	Homo sapiens	4-23
23077721-6	2012	We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators.	Hemicholinium 3	164-179	solute carrier family 5 member 7	Homo sapiens	260-263
23077721-6	2012	We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators.	Hemicholinium 3	181-186	solute carrier family 5 member 7	Homo sapiens	260-263
22483272-2	2012	The solute carrier 44A1 (SLC44A1), also referred to as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter with an intermediate affinity for choline; this transport is Na(+)-independent and sensitive to inhibition by the drug hemicholinium-3.	Hemicholinium 3	262-275	solute carrier family 44 member 1	Homo sapiens	25-32
22483272-2	2012	The solute carrier 44A1 (SLC44A1), also referred to as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter with an intermediate affinity for choline; this transport is Na(+)-independent and sensitive to inhibition by the drug hemicholinium-3.	Hemicholinium 3	262-275	solute carrier family 44 member 1	Homo sapiens	55-89
22483272-2	2012	The solute carrier 44A1 (SLC44A1), also referred to as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter with an intermediate affinity for choline; this transport is Na(+)-independent and sensitive to inhibition by the drug hemicholinium-3.	Hemicholinium 3	262-275	solute carrier family 44 member 1	Homo sapiens	91-95
17971421-2	2008	In this study, we investigated mechanisms by which acute exposure to peroxynitrite impairs function of the sodium-dependent hemicholinium-3 (HC-3)-sensitive choline transporter (CHT) that provides substrate for acetylcholine synthesis.	Hemicholinium 3	124-139	solute carrier family 6 member 8	Rattus norvegicus	157-176
21836465-6	2011	The CDP-choline-induced antihyperalgesic effect was prevented by central administration of the neuronal high-affinity choline uptake inhibitor hemicholinium-3 (1 microg), the nonselective nicotinic receptor antagonist mecamylamine (50 microg), the alpha7-selective nicotinic ACh receptor antagonist, alpha-bungarotoxin (2 microg) and the gamma-aminobutyric acid B receptor antagonist CGP-35348 (20 microg).	Hemicholinium 3	143-158	cut-like homeobox 1	Rattus norvegicus	4-7
18023504-8	2008	Inhibition of HACU by hemicholinium-3 (HC-3) in vivo reduced extracellular levels of ACh by 60% in wild-type mice but by more than 90% in AChE-deficient mice.	Hemicholinium 3	22-35	high affinity choline uptake	Mus musculus	14-18
18023504-8	2008	Inhibition of HACU by hemicholinium-3 (HC-3) in vivo reduced extracellular levels of ACh by 60% in wild-type mice but by more than 90% in AChE-deficient mice.	Hemicholinium 3	22-35	acetylcholinesterase	Mus musculus	138-142
22016532-6	2011	Specific inhibitor hemicholinium-3 decreases the constitutive internalization rate and thereby increases cell-surface CHT1 expression.	Hemicholinium 3	19-34	solute carrier family 5 member 7	Homo sapiens	118-122
19357133-2	2009	The purpose of this study was to analyze subcellular localization of the solute carrier 44A1 (SLC44A1), a plasma membrane choline transporter sensitive to inhibition by hemicholinium-3.	Hemicholinium 3	169-184	solute carrier family 44, member 1	Mus musculus	73-92
19357133-2	2009	The purpose of this study was to analyze subcellular localization of the solute carrier 44A1 (SLC44A1), a plasma membrane choline transporter sensitive to inhibition by hemicholinium-3.	Hemicholinium 3	169-184	solute carrier family 44, member 1	Mus musculus	94-101
17971421-2	2008	In this study, we investigated mechanisms by which acute exposure to peroxynitrite impairs function of the sodium-dependent hemicholinium-3 (HC-3)-sensitive choline transporter (CHT) that provides substrate for acetylcholine synthesis.	Hemicholinium 3	124-139	solute carrier family 6 member 8	Rattus norvegicus	178-181
17971421-2	2008	In this study, we investigated mechanisms by which acute exposure to peroxynitrite impairs function of the sodium-dependent hemicholinium-3 (HC-3)-sensitive choline transporter (CHT) that provides substrate for acetylcholine synthesis.	Hemicholinium 3	141-145	solute carrier family 6 member 8	Rattus norvegicus	157-176
17971421-2	2008	In this study, we investigated mechanisms by which acute exposure to peroxynitrite impairs function of the sodium-dependent hemicholinium-3 (HC-3)-sensitive choline transporter (CHT) that provides substrate for acetylcholine synthesis.	Hemicholinium 3	141-145	solute carrier family 6 member 8	Rattus norvegicus	178-181
16539662-3	2006	Pressure ejections of hemicholinium-3 (HC-3), a selective CHT blocker, dose-dependently reduced the uptake rate of exogenous choline as well as that of choline generated in response to terminal depolarization.	Hemicholinium 3	22-37	solute carrier family 6 member 8	Rattus norvegicus	58-61
17560001-9	2007	In conclusion, inhibition of (Na(+)/K(+))ATPase by AlCl(3) and ouabain jeopardized the high-affinity (Na(+)-dependent, hemicholinium-3 sensitive) uptake of choline and the Ca(2+)-dependent, K(+) depolarization evoked release of acetylcholine by rat, cuttlefish and torpedo synaptosomal fractions.	Hemicholinium 3	119-134	TANK binding kinase 1	Homo sapiens	30-47
16942753-10	2006	CDP-choline-induced antinociception was prevented by the neuronal high affinity choline uptake inhibitor HC-3 (1 microg; i.c.v.	Hemicholinium 3	105-109	cut-like homeobox 1	Rattus norvegicus	0-3
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	28-43	solute carrier family 5 member 7	Homo sapiens	4-8
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	28-43	solute carrier family 5 member 7	Homo sapiens	184-188
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	45-49	solute carrier family 5 member 7	Homo sapiens	4-8
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	45-49	solute carrier family 5 member 7	Homo sapiens	184-188
16763028-6	2006	Using embryonic primary cultures, we demonstrate that CHO-1 mediates hemicholinium-3-sensitive, high-affinity choline uptake that can be enhanced with depolarization in a Ca(2+)-dependent manner supporting ACh synthesis.	Hemicholinium 3	69-84	High-affinity choline transporter 1	Caenorhabditis elegans	54-59
16539662-3	2006	Pressure ejections of hemicholinium-3 (HC-3), a selective CHT blocker, dose-dependently reduced the uptake rate of exogenous choline as well as that of choline generated in response to terminal depolarization.	Hemicholinium 3	39-43	solute carrier family 6 member 8	Rattus norvegicus	58-61
15474312-5	2004	Expression of His-tagged mCTL1 in Cos-7 cells produces an increase in saturable choline uptake that is sensitive to a Na(+)-ion gradient, ethanolamine and the Ca(2+)-channel blocker verapamil, and insensitive to low concentrations of hemicholinium-3.	Hemicholinium 3	234-249	cytotoxic T lymphocyte response 1	Mus musculus	25-30
16500685-10	2006	The choline transporter inhibitor hemicholinium-3 blocked the neuroprotective effect of ALC.	Hemicholinium 3	34-49	solute carrier family 6 member 8	Rattus norvegicus	4-23
12675135-6	2003	CHT1 mediates Na(+)- and Cl(-)-dependent choline uptake with high sensitivity to hemicholinium-3.	Hemicholinium 3	81-96	solute carrier family 5 member 7	Homo sapiens	0-4
15173594-4	2004	Hemicholinium-3-sensitive choline uptake and subsequent ACh synthesis are specifically lost in CHT-/- mouse brains.	Hemicholinium 3	0-15	solute carrier family 5 (choline transporter), member 7	Mus musculus	95-98
15090548-1	2004	CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter.	Hemicholinium 3	38-53	solute carrier family 5 member 7	Homo sapiens	0-4
15090548-1	2004	CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter.	Hemicholinium 3	55-60	solute carrier family 5 member 7	Homo sapiens	0-4
15090548-4	2004	Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4.	Hemicholinium 3	79-83	solute carrier family 5 member 7	Homo sapiens	47-51
15090548-4	2004	Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4.	Hemicholinium 3	79-83	pro-apoptotic WT1 regulator	Homo sapiens	161-166
15026114-3	2004	administration of hemicholinium-3 (HC-3) (1 microg), a specific inhibitor of the high-affinity choline uptake (HACU) in brain cholinergic neurons, impaired retention test performance of a one-trial step-through inhibitory avoidance response in adult male CF-1 mice.	Hemicholinium 3	18-33	high affinity choline uptake	Mus musculus	111-115
15026114-3	2004	administration of hemicholinium-3 (HC-3) (1 microg), a specific inhibitor of the high-affinity choline uptake (HACU) in brain cholinergic neurons, impaired retention test performance of a one-trial step-through inhibitory avoidance response in adult male CF-1 mice.	Hemicholinium 3	35-39	high affinity choline uptake	Mus musculus	111-115
15026114-5	2004	After the completion of the retention test at each of the training-test interval that were studied, the HACU in the hippocampus of HC-3-treated mice was not significantly different from that of saline-injected (1 microl) control groups.	Hemicholinium 3	131-135	high affinity choline uptake	Mus musculus	104-108
14573394-5	2003	Like nicotine, the contraction induced by 100 nM urotensin II was inhibited by treatment with atropine, hexamethonium, D-tubocurarine, tetrodotoxin or hemicholinium-3, and enhanced by physostigmine.	Hemicholinium 3	151-166	urotensin 2	Homo sapiens	49-61
14585997-1	2003	Presynaptic synthesis of acetylcholine (ACh) requires a steady supply of choline, acquired by a plasma membrane, hemicholinium-3-sensitive (HC-3) choline transporter (CHT).	Hemicholinium 3	113-128	solute carrier family 6 member 8	Rattus norvegicus	146-165
12742520-9	2003	hemicholinium-3 pretreatment (20 microg), greatly attenuated the pressor effect of CDP-choline in both conditions.	Hemicholinium 3	0-13	cut-like homeobox 1	Rattus norvegicus	83-86
9566614-0	1998	AF64A-induced changes in N-myc expression in the LA-N-2 human neuroblastoma cell line are modulated by choline and hemicholinium-3.	Hemicholinium 3	115-128	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
12628469-6	2003	Consistent with that finding, specific binding of [3H]hemicholinium-3 (HC-3), an inhibitor of CHT1, and HC-3-sensitive [3H]choline uptake were also detected in MOLT-3 cells.	Hemicholinium 3	54-69	solute carrier family 5 member 7	Homo sapiens	94-98
10959528-2	2000	Either the selective M1 muscarinic receptor antagonist pirenzepine (50 microg) or the choline uptake inhibitor hemicholinium-3 (5 microg) impaired APDT selection accuracy, but neither affected the induction of LTP in the hippocampal CA1 region in anesthetized rats.	Hemicholinium 3	111-126	carbonic anhydrase 1	Rattus norvegicus	233-236
9767089-3	1998	Addition of 10 mM hemicholinium-3, a choline transport inhibitor, or disruption of the CTR gene, which encodes a choline transporter, inhibited the growth of the cho1/pss mutant in the presence of choline, but not in the presence of 0.1 mM diC8PC.	Hemicholinium 3	18-33	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	162-166
12571220-1	2003	UNLABELLED: 4,4"-Bis-1-hydroxy-2-(4-methylpiperidin-1-yl)ethyl-biphenyl (A-4), a tertiary amine analog of hemicholinium-3 (HC-3), is an inhibitor of the sodium-dependent high-affinity choline uptake (HACU) system.	Hemicholinium 3	106-121	high affinity choline uptake	Mus musculus	200-204
12031853-6	2002	The choline-induced rise in plasma vasopressin levels was greatly attenuated by hemicholinium-3 (HC-3; 20 microg; i.c.v.	Hemicholinium 3	97-101	arginine vasopressin	Rattus norvegicus	35-46
12012025-23	2002	In haemorrhaged rats, the pressor effect of CDP-choline was attenuated by hemicholinium-3 and mecamylamine while atropine failed to alter the pressor response to CDP-choline.	Hemicholinium 3	74-89	cut-like homeobox 1	Rattus norvegicus	44-47
11553644-2	2001	Expression of OCT1 and OCT2 in Xenopus oocytes increased hemicholinium-3-sensitive choline uptake.	Hemicholinium 3	57-72	POU class 2 homeobox 1 S homeolog	Xenopus laevis	14-18
11553644-2	2001	Expression of OCT1 and OCT2 in Xenopus oocytes increased hemicholinium-3-sensitive choline uptake.	Hemicholinium 3	57-72	POU class 2 homeobox 2 L homeolog	Xenopus laevis	23-27
11709061-1	2001	In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT).	Hemicholinium 3	157-172	solute carrier family 5 (choline transporter), member 7	Mus musculus	190-209
11709061-1	2001	In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT).	Hemicholinium 3	157-172	solute carrier family 5 (choline transporter), member 7	Mus musculus	211-214
11709061-1	2001	In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT).	Hemicholinium 3	174-178	solute carrier family 5 (choline transporter), member 7	Mus musculus	190-209
11709061-1	2001	In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT).	Hemicholinium 3	174-178	solute carrier family 5 (choline transporter), member 7	Mus musculus	211-214
11709061-15	2001	Expression of mCHT in COS-7 cells results in high-affinity [(3)H]HC-3-binding sites (K(d)=5 nM), and Na(+)- and Cl(-)-dependent HC-3-sensitive choline uptake (K(m)=2 microM), assessed in resealed membrane vesicles.	Hemicholinium 3	65-69	solute carrier family 5 (choline transporter), member 7	Mus musculus	14-18
11709061-15	2001	Expression of mCHT in COS-7 cells results in high-affinity [(3)H]HC-3-binding sites (K(d)=5 nM), and Na(+)- and Cl(-)-dependent HC-3-sensitive choline uptake (K(m)=2 microM), assessed in resealed membrane vesicles.	Hemicholinium 3	128-132	solute carrier family 5 (choline transporter), member 7	Mus musculus	14-18
10822168-4	2000	Furthermore, the CK inhibitor hemicholinium-3 (HC-3) inhibited insulin- and IGF-I-induced DNA synthesis in the CK overexpressors, but not in the vector control cells.	Hemicholinium 3	30-45	insulin	Homo sapiens	63-70
10822168-4	2000	Furthermore, the CK inhibitor hemicholinium-3 (HC-3) inhibited insulin- and IGF-I-induced DNA synthesis in the CK overexpressors, but not in the vector control cells.	Hemicholinium 3	30-45	insulin like growth factor 1	Homo sapiens	76-81
10822168-4	2000	Furthermore, the CK inhibitor hemicholinium-3 (HC-3) inhibited insulin- and IGF-I-induced DNA synthesis in the CK overexpressors, but not in the vector control cells.	Hemicholinium 3	47-51	insulin	Homo sapiens	63-70
10822168-4	2000	Furthermore, the CK inhibitor hemicholinium-3 (HC-3) inhibited insulin- and IGF-I-induced DNA synthesis in the CK overexpressors, but not in the vector control cells.	Hemicholinium 3	47-51	insulin like growth factor 1	Homo sapiens	76-81
9778051-4	1998	Hemicholinium-3 (HC-3), an inhibitor of choline kinase, strongly inhibited UV-induced AP-1 activity.	Hemicholinium 3	0-15	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
9778051-4	1998	Hemicholinium-3 (HC-3), an inhibitor of choline kinase, strongly inhibited UV-induced AP-1 activity.	Hemicholinium 3	17-21	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
9566614-9	1998	Presence of choline or hemicholinium-3 prevented the AF64A-induced decrease of N-myc levels by competing with, or inhibiting the choline transport mechanism by which AF64A enters the cell, respectively.	Hemicholinium 3	23-38	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	79-84
8937895-3	1996	High-affinity choline uptake (HACU, the rate-limiting step in acetlcholine synthesis) and binding to [3H]-hemicholinium-3 (HC-3, a specific ligand for the choline transporter) were chosen as indicators of acetylcholine synthesis.	Hemicholinium 3	123-127	solute carrier family 6 member 8	Rattus norvegicus	155-174
9375677-0	1997	Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice.	Hemicholinium 3	9-22	acetylcholinesterase	Mus musculus	89-109
9393874-4	1997	The importance of ChoK for the regulation of cell proliferation has also been proposed since an inhibitor for this enzyme, hemicholinium-3 (HC-3), drastically reduces entry into the S phase after stimulation with growth factors.	Hemicholinium 3	123-138	choline kinase alpha	Mus musculus	18-22
9393874-4	1997	The importance of ChoK for the regulation of cell proliferation has also been proposed since an inhibitor for this enzyme, hemicholinium-3 (HC-3), drastically reduces entry into the S phase after stimulation with growth factors.	Hemicholinium 3	140-144	choline kinase alpha	Mus musculus	18-22
9393874-5	1997	Here we report the synthesis of several new compounds which are highly specific inhibitors for ChoK, with up to 1000-fold or 600-fold increased inhibitory activity, compared to HC-3 under ex vivo or in vitro conditions respectively.	Hemicholinium 3	177-181	choline kinase alpha	Mus musculus	95-99
7532755-0	1994	Effect of hemicholinium-3 on the hypothalamic concentration of a cytochemically detectable glucose-6-phosphate dehydrogenase-stimulating substance.	Hemicholinium 3	10-25	glucose-6-phosphate dehydrogenase	Rattus norvegicus	91-124
8936553-6	1996	The depolarization may decrease the influx of Ca2+ and the reuptake of choline+, as suggested by an observed synergism with tetraethylammonium CI and hemicholinium-3 Br, which antagonize the reuptake of choline+.	Hemicholinium 3	150-163	carbonic anhydrase 2	Rattus norvegicus	46-49
8899632-11	1996	When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter.	Hemicholinium 3	302-317	acetylcholinesterase (Cartwright blood group)	Homo sapiens	5-9
8899632-11	1996	When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter.	Hemicholinium 3	319-323	acetylcholinesterase (Cartwright blood group)	Homo sapiens	5-9
7896942-1	1995	A putative choline transporter (CHOT1) has been cloned from rat brain and is reported to express a high-affinity, sodium-dependent, hemicholinium-3-insensitive choline transporter in oocytes.	Hemicholinium 3	132-145	solute carrier family 6 member 8	Rattus norvegicus	11-30
7896942-1	1995	A putative choline transporter (CHOT1) has been cloned from rat brain and is reported to express a high-affinity, sodium-dependent, hemicholinium-3-insensitive choline transporter in oocytes.	Hemicholinium 3	132-145	solute carrier family 6 member 8	Rattus norvegicus	32-37
19215464-6	1991	IL cells incubated in the presence of [(14)C]choline (1 muM) were able to synthesize [(14)C]ACh and the accumulation of the new ACh was inhibited by hemicholinium-3 (30 muM), a competitive inhibitor of high affinity choline uptake at cholinergic nerve terminals.	Hemicholinium 3	149-164	latexin	Homo sapiens	56-59
7704621-3	1994	Ibotenic acid lesion resulted in a striking loss of acetylcholinesterase (AChE) staining in the lesioned Nbm which is associated with a 60% decrease in AChE staining and a 30% reduction in [3H]hemicholinium-3 binding in frontal and parietal cortical regions as well fore- and hindlimb areas ipsilateral to the lesion, being more prominent in the more rostral cortical regions.	Hemicholinium 3	193-208	acetylcholinesterase	Rattus norvegicus	52-72
7704621-3	1994	Ibotenic acid lesion resulted in a striking loss of acetylcholinesterase (AChE) staining in the lesioned Nbm which is associated with a 60% decrease in AChE staining and a 30% reduction in [3H]hemicholinium-3 binding in frontal and parietal cortical regions as well fore- and hindlimb areas ipsilateral to the lesion, being more prominent in the more rostral cortical regions.	Hemicholinium 3	193-208	acetylcholinesterase	Rattus norvegicus	74-78
18475595-4	1994	Neurogenic pathways were also involved since pretreatment of ileum with hexamethonium, hemicholinium or tetrodotoxin impaired the contractile effect of interferon gamma.	Hemicholinium 3	87-100	interferon gamma	Rattus norvegicus	152-168
8467907-2	1993	Choline transporter activity was titrated with hemicholinium-3, a known competitive inhibitor of the transporter.	Hemicholinium 3	47-62	solute carrier family 6 member 8	Rattus norvegicus	0-19
1504265-0	1992	Inhibition of acetylcholinesterase by hemicholiniums, conformationally constrained choline analogues.	Hemicholinium 3	38-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
1504265-3	1992	2-Substituted-2-hydroxy-4,4-dimethylmorpholiniums (hemicholiniums) inhibit acetylcholinesterase (EC 3.1.1.7)-catalyzed hydrolysis of acetylthiocholine (ATCh).	Hemicholinium 3	51-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
1504265-7	1992	The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline.	Hemicholinium 3	85-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
1504265-10	1992	The binding by AChE of the hemicholiniums of various sizes and the strong binding of 5 support an earlier proposal [Schowen, K. B., Smissman, E. E., and Stephen, W. F., Jr. (1975) J. Med.	Hemicholinium 3	27-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-19
19215464-6	1991	IL cells incubated in the presence of [(14)C]choline (1 muM) were able to synthesize [(14)C]ACh and the accumulation of the new ACh was inhibited by hemicholinium-3 (30 muM), a competitive inhibitor of high affinity choline uptake at cholinergic nerve terminals.	Hemicholinium 3	149-164	latexin	Homo sapiens	169-172
2384747-1	1990	The objective of this study was to determine the effect of age and chronic intracerebral administration of nerve growth factor (NGF) on the activity of the presynaptic cholinergic neuronal markers hemicholinium-sensitive high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) in the brain of Fisher 344 male rats.	Hemicholinium 3	197-210	choline O-acetyltransferase	Rattus norvegicus	261-286
2213567-1	1990	A-4 and A-5 are tertiary and N-methyl quaternary 4-methylpiperidine analogs of hemicholinium-3 (HC-3).	Hemicholinium 3	79-94	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-3
2213567-1	1990	A-4 and A-5 are tertiary and N-methyl quaternary 4-methylpiperidine analogs of hemicholinium-3 (HC-3).	Hemicholinium 3	79-94	immunoglobulin kappa variable 2D-26	Homo sapiens	8-11
2213567-1	1990	A-4 and A-5 are tertiary and N-methyl quaternary 4-methylpiperidine analogs of hemicholinium-3 (HC-3).	Hemicholinium 3	96-100	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-3
2213567-1	1990	A-4 and A-5 are tertiary and N-methyl quaternary 4-methylpiperidine analogs of hemicholinium-3 (HC-3).	Hemicholinium 3	96-100	immunoglobulin kappa variable 2D-26	Homo sapiens	8-11
2019995-0	1991	Hemicholinium-3 derivatives A-4 and A-5 alter choline metabolism in NB41A3 neuroblastoma cells.	Hemicholinium 3	0-15	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	28-31
2065716-0	1991	Hemicholinium-3 derivatives A-4 and A-5 affect choline and acetylcholine metabolism.	Hemicholinium 3	0-15	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	28-31
2732947-1	1989	Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H]hemicholinium-3 ([ 3H]HCh-3) and the uptake of [3H]choline.	Hemicholinium 3	178-193	phospholipase A2 group IB	Homo sapiens	0-16
2125863-1	1990	In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats.	Hemicholinium 3	199-212	acyl-CoA thioesterase 12	Rattus norvegicus	63-66
2125863-1	1990	In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats.	Hemicholinium 3	199-212	acyl-CoA thioesterase 12	Rattus norvegicus	178-181
2125863-1	1990	In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats.	Hemicholinium 3	199-212	acyl-CoA thioesterase 12	Rattus norvegicus	178-181
2125863-1	1990	In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats.	Hemicholinium 3	199-212	acyl-CoA thioesterase 12	Rattus norvegicus	178-181
2732947-1	1989	Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H]hemicholinium-3 ([ 3H]HCh-3) and the uptake of [3H]choline.	Hemicholinium 3	178-193	phospholipase A2 group IB	Homo sapiens	18-22
3409952-3	1988	The order of potency for choline uptake inhibition of piperidine substituted HC-3 molecule was as follows: 4-methylpiperidine (A-5 and CA-5) much greater than HC-3 much greater than unsubstituted piperidines (CA-1 and A-1) much greater than 2- or 3-methylpiperidine (A-2 and A-3) and 4-hydroxypiperidine (A-7).	Hemicholinium 3	77-81	carbonic anhydrase 1	Rattus norvegicus	209-221
3498823-20	1987	From hemidiaphragms with active cholinesterase about 120 pmol ACh was lost after prolonged nerve stimulation or incubation with 50 mM-KCl in the presence of hemicholinium-3, and about 35 pmol remained in the tissue.	Hemicholinium 3	157-172	butyrylcholinesterase	Rattus norvegicus	32-46
2443476-4	1987	Pretreatment with hemicholinium 3, an acetylcholine synthesis inhibitor, inhibited the contractile response to SP.	Hemicholinium 3	18-33	tachykinin precursor 1	Homo sapiens	111-113
3575480-1	1987	Ten adult male Sprague-Dawley rats were infused with hemicholinium (HC-3) using mini-osmotic pumps over a 14 day period through bilateral, chronically implanted cannulae in the nucleus basalis magnocellularis (nbm).	Hemicholinium 3	53-66	Hypercalciuria QTL 3	Rattus norvegicus	68-72
3666401-0	1987	Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens.	Hemicholinium 3	17-30	arginine vasopressin	Rattus norvegicus	70-73
4045465-4	1985	The activity was decreased by hemicholinium-3, an inhibitor of choline uptake and slightly activated by neostigmine, an acetylcholinesterase inhibitor.	Hemicholinium 3	30-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-140
3019820-5	1986	Hc-3 plus 3,4-diaminopyridine (3,4-DAP) increased synaptic transmission, TP, and PTP from postganglionic CAP responses to supramaximal preganglionic stimulation.	Hemicholinium 3	0-4	death associated protein	Homo sapiens	35-38
6263592-9	1981	Prior intracisternal administration of hemicholinium-3 blocked the plasma responses of all three catecholamines to intracisternal beta-endorphin, providing evidence for the involvement of central cholinergic neurons in the mechanism mediating beta-endorphin-induced increases in plasma catecholamines.	Hemicholinium 3	39-54	proopiomelanocortin	Homo sapiens	130-144
6664459-2	1983	injection of hemicholinium-3 (HC-3; 20 micrograms), which depletes acetylcholine stores in brain, reduced the increase in mean arterial pressure (MAP) and the drinking, but not the decrease in heart rate (HR), induced by intraventricular injection of angiotensin II (ANG II, 50 and 100 ng) in conscious rats.	Hemicholinium 3	13-28	angiotensinogen	Rattus norvegicus	251-265
6664459-2	1983	injection of hemicholinium-3 (HC-3; 20 micrograms), which depletes acetylcholine stores in brain, reduced the increase in mean arterial pressure (MAP) and the drinking, but not the decrease in heart rate (HR), induced by intraventricular injection of angiotensin II (ANG II, 50 and 100 ng) in conscious rats.	Hemicholinium 3	13-28	angiotensinogen	Rattus norvegicus	267-273
6664459-2	1983	injection of hemicholinium-3 (HC-3; 20 micrograms), which depletes acetylcholine stores in brain, reduced the increase in mean arterial pressure (MAP) and the drinking, but not the decrease in heart rate (HR), induced by intraventricular injection of angiotensin II (ANG II, 50 and 100 ng) in conscious rats.	Hemicholinium 3	30-34	angiotensinogen	Rattus norvegicus	251-265
6664459-2	1983	injection of hemicholinium-3 (HC-3; 20 micrograms), which depletes acetylcholine stores in brain, reduced the increase in mean arterial pressure (MAP) and the drinking, but not the decrease in heart rate (HR), induced by intraventricular injection of angiotensin II (ANG II, 50 and 100 ng) in conscious rats.	Hemicholinium 3	30-34	angiotensinogen	Rattus norvegicus	267-273
2864263-5	1985	In contrast, the pressor response to ANG II was only weakly inhibited by hemicholinium-3 and the bradycardia was unaffected.	Hemicholinium 3	73-88	angiotensinogen	Rattus norvegicus	37-43
2987726-6	1985	The grooming induced by ACTH was also inhibited by prior intracerebroventricular administration of hemicholinium-3, a cholinergic antagonist that acts presynaptically by inhibiting the uptake of choline and hence, the synthesis of acetylcholine.	Hemicholinium 3	99-114	proopiomelanocortin	Homo sapiens	24-28
6827521-5	1983	When compared on an equivalent concentration basis, HC3-BrM effected substantially greater inhibition of SDHACU than HC-3 and is, thus, at present the most potent known synthetic inhibitor of this uptake system.	Hemicholinium 3	117-121	CYCS pseudogene 24	Homo sapiens	52-55
6263592-9	1981	Prior intracisternal administration of hemicholinium-3 blocked the plasma responses of all three catecholamines to intracisternal beta-endorphin, providing evidence for the involvement of central cholinergic neurons in the mechanism mediating beta-endorphin-induced increases in plasma catecholamines.	Hemicholinium 3	39-54	proopiomelanocortin	Homo sapiens	243-257
119692-5	1979	The DA releasing effect of TRH was completely blocked by cholinergic blockers (scopolamine, hexamethonium and hemicholinium), Ca2+ chelator(EGTA), Ca2+ antagonist(CoCl2) and Ca2+ influx blocker(D-600) or by the removal of Ca2+ from the medium.	Hemicholinium 3	110-123	thyrotropin releasing hormone	Rattus norvegicus	27-30
7248753-4	1981	The hyperglycemic response to intracerebral beta-endorphin was also blocked by either intracerebral hemicholinium-3 or somatostatin, supporting both a cholinergic link and a somatostatin neuron in the brain mechanism regulating endorphin-induced stimulation of sympathetic outflow.	Hemicholinium 3	100-115	proopiomelanocortin	Homo sapiens	44-58
5709790-0	1968	Inhibition of acetylcholinesterase in vitro by hemicholinium-3.	Hemicholinium 3	47-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
6755-0	1976	The effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (HC-3) in the rat.	Hemicholinium 3	72-87	butyrylcholinesterase	Rattus norvegicus	14-28
6755-0	1976	The effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (HC-3) in the rat.	Hemicholinium 3	89-93	butyrylcholinesterase	Rattus norvegicus	14-28
1123727-2	1975	Hemicholiniums-3 and -15, but not terphenylhemicholinium-3, were substrates of ChAc.	Hemicholinium 3	0-14	choline O-acetyltransferase	Rattus norvegicus	79-83
4378560-0	1965	Effect of hemicholinium on the catecholamine depleting actions of reserpine, morphine and insulin in rabbit tissues.	Hemicholinium 3	10-23	insulin	Oryctolagus cuniculus	90-97
33640406-2	2021	CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.	Hemicholinium 3	57-72	solute carrier family 5 member 7	Homo sapiens	0-4
33640406-3	2021	Although the substrate choline and the inhibitor hemicholinium-3 are well-established ligands of CHT 1, few potent ligands other than choline analogs have been reported.	Hemicholinium 3	49-64	solute carrier family 5 member 7	Homo sapiens	97-102
33640406-6	2021	We found that morantel as well as other tetrahydropyrimidines, pyrantel and oxantel, potently inhibits the high-affinity choline uptake activity of CHT 1 in a competitive manner similar to the inhibitor hemicholinium-3.	Hemicholinium 3	203-218	solute carrier family 5 member 7	Homo sapiens	148-153
28700094-4	2017	Hemicholinium-3 (HC-3) at concentrations less than 1 muM, selectively inhibited the uptake of [3 H]choline by the high affinity-choline transporter 1 and had no effect on basal and electrically evoked [3 H]efflux in superfusion experiments.	Hemicholinium 3	0-15	solute carrier family 5 member 7	Rattus norvegicus	114-149
29623856-9	2018	Choline uptake inhibition by hemicholinium did increase the AChE activity but not in the erythroid differentiated K562 cell line.	Hemicholinium 3	29-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
28700094-4	2017	Hemicholinium-3 (HC-3) at concentrations less than 1 muM, selectively inhibited the uptake of [3 H]choline by the high affinity-choline transporter 1 and had no effect on basal and electrically evoked [3 H]efflux in superfusion experiments.	Hemicholinium 3	17-21	solute carrier family 5 member 7	Rattus norvegicus	114-149
27149373-11	2016	Remarkably, phosphorylation drastically increased the sensitivity of CKbeta to hemicholinium-3 (HC-3) inhibition by about 30-fold.	Hemicholinium 3	79-94	creatine kinase B	Homo sapiens	69-75
28577989-0	2017	Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.	Hemicholinium 3	0-15	solute carrier family 5 member 7	Homo sapiens	106-125
28577989-0	2017	Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.	Hemicholinium 3	0-15	solute carrier family 5 member 7	Homo sapiens	127-130
28483526-8	2017	We also intraperitoneally injected the rats with hemicholinium-3 (HC-3, a specific inhibitor of CHT1).	Hemicholinium 3	49-64	solute carrier family 5 member 7	Rattus norvegicus	96-100
27149373-11	2016	Remarkably, phosphorylation drastically increased the sensitivity of CKbeta to hemicholinium-3 (HC-3) inhibition by about 30-fold.	Hemicholinium 3	96-100	creatine kinase B	Homo sapiens	69-75