PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27212182-1	2016	OBJECTIVE: To investigate the effect of increasing Mn+2 concentrations on superoxide dismutase 2 (SOD2) activity in pre-senescent and senescent cultured fibroblasts, and to determine the Km Mn+2 values required to achieve maximal SOD2 activities in such cells.	mn+2	51-55	superoxide dismutase 2	Homo sapiens	74-96
27212182-1	2016	OBJECTIVE: To investigate the effect of increasing Mn+2 concentrations on superoxide dismutase 2 (SOD2) activity in pre-senescent and senescent cultured fibroblasts, and to determine the Km Mn+2 values required to achieve maximal SOD2 activities in such cells.	mn+2	51-55	superoxide dismutase 2	Homo sapiens	98-102
8426076-3	1993	This study examined the effect of Mn+2 on fibrinogen interactions with intact platelets.	mn+2	34-38	fibrinogen beta chain	Homo sapiens	42-52
8426076-7	1993	Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton.	mn+2	0-4	fibrinogen beta chain	Homo sapiens	42-52
8426076-7	1993	Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton.	mn+2	0-4	coagulation factor II, thrombin	Homo sapiens	70-78
8426076-7	1993	Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton.	mn+2	0-4	fibrinogen beta chain	Homo sapiens	136-146
8426076-8	1993	Only 31% +/- 10% of fibrinogen bound to thrombin-stimulated platelets for 60 minutes in the presence of Mn+2 associated with the cytoskeleton (p < 0.05), compared with 61% +/- 14% and 75% +/- 20% of fibrinogen bound to control platelets incubated with and without Ca+2, respectively.	mn+2	104-108	fibrinogen beta chain	Homo sapiens	20-30
8426076-8	1993	Only 31% +/- 10% of fibrinogen bound to thrombin-stimulated platelets for 60 minutes in the presence of Mn+2 associated with the cytoskeleton (p < 0.05), compared with 61% +/- 14% and 75% +/- 20% of fibrinogen bound to control platelets incubated with and without Ca+2, respectively.	mn+2	104-108	coagulation factor II, thrombin	Homo sapiens	40-48
8426076-9	1993	Mn+2 further inhibited large adenosine diphosphate- or thrombin-induced platelet aggregate formation and reduced the ability of platelets to retract fibrin clots.	mn+2	0-4	coagulation factor II, thrombin	Homo sapiens	55-63
8426076-10	1993	These data suggest that Mn+2 alters GPIIb-IIIa function relative to native fibrinogen and support a role for the stabilization of platelet-fibrinogen interactions in platelet aggregation and clot retraction.	mn+2	24-28	integrin subunit alpha 2b	Homo sapiens	36-41
1406294-3	1992	The 54Mn content of the Tf peak increased with increasing incubation time in vitro, suggesting the oxidation of Mn+2 to Mn+3 before its association with Tf.	mn+2	112-116	transferrin	Homo sapiens	24-26