PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 15504958-9 2004 Finally, CNTF(Ax15) administration improved the metabolic profile in both diet-induced obese C57BL/6J and UCP1-DTA mice and resulted in a significantly improved glycemic response to oral glucose tolerance tests in CNTF(Ax15)-treated UCP1-DTA compared with pair-fed mice of similar body weight. deoxythymidylyl-3'-5'-deoxyadenylate 111-114 ciliary neurotrophic factor Mus musculus 9-13 17525215-7 2007 RESULTS: Cone ablation by the cone-DTA transgene eliminated folds in the rd7/rd7 retina, whereas chemical ablation of up to 30% of rods (by exposure to MNU at P13) had little or no effect on folds in the rd7/rd7 retina. deoxythymidylyl-3'-5'-deoxyadenylate 35-38 nuclear receptor subfamily 2, group E, member 3 Mus musculus 73-76 15521051-8 2005 CONCLUSIONS: DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. deoxythymidylyl-3'-5'-deoxyadenylate 13-17 H19, imprinted maternally expressed transcript (non-protein coding) Rattus norvegicus 96-99 15521051-8 2005 CONCLUSIONS: DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. deoxythymidylyl-3'-5'-deoxyadenylate 13-17 insulin-like growth factor 2 Rattus norvegicus 103-107 15521051-8 2005 CONCLUSIONS: DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. deoxythymidylyl-3'-5'-deoxyadenylate 127-131 insulin-like growth factor 2 Rattus norvegicus 103-107 17427200-4 2007 METHODS: Using a degradable, poly(beta-amino ester) polymer, poly(butane diol diacrylate co amino pentanol) (C32), we developed a nanoparticulate system to deliver a diphtheria toxin suicide gene (DT-A) driven by a prostate specific promoter to cells. deoxythymidylyl-3'-5'-deoxyadenylate 197-201 CKLF-like MARVEL transmembrane domain containing 2A Mus musculus 109-112 16791847-2 2006 We have lately described the R26:lacZ/DT-A line (Brockschnieder et al., 2004, Mol Cell Biol 24:7636-7642) in which a loxP-conditional DTA allele was introduced into the ubiquitously expressed Rosa26 locus. deoxythymidylyl-3'-5'-deoxyadenylate 134-137 gene trap ROSA 26, Philippe Soriano Mus musculus 192-198 16112608-5 2005 Novel complexes of Co(II), Ni(II) and Cu(II) with the pyrimidine azodye have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic as well as ESR spectral studies The thermal decomposition of the metal complexes is studied by TGA and DTA techniques. deoxythymidylyl-3'-5'-deoxyadenylate 323-326 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-25 16379285-2 2005 HO2 x CH3 OH (Thr = DL-Threonine, Phen = o-Phenanthroline), which has not been published, was synthesized and characterized by elemental analysis, IR spectroscopy, and TG-DTA. deoxythymidylyl-3'-5'-deoxyadenylate 171-174 heme oxygenase 2 Homo sapiens 0-3 15504958-9 2004 Finally, CNTF(Ax15) administration improved the metabolic profile in both diet-induced obese C57BL/6J and UCP1-DTA mice and resulted in a significantly improved glycemic response to oral glucose tolerance tests in CNTF(Ax15)-treated UCP1-DTA compared with pair-fed mice of similar body weight. deoxythymidylyl-3'-5'-deoxyadenylate 111-114 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 106-110 14694219-7 2003 On CD, wild-type mice accumulated less body fat (16.9%) than UCP-DTA (32.6%) mice, although they had a higher overall energy intake. deoxythymidylyl-3'-5'-deoxyadenylate 65-68 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-64 10470226-2 1999 The clinical significance of serum thyroid peroxidase (TPO) for differentiated thyroid carcinomas(DTA) is estimated differently. deoxythymidylyl-3'-5'-deoxyadenylate 98-101 thyroid peroxidase Homo sapiens 35-53 10816022-1 2000 The program makes it possible to obtain kinetics profiles (DTA, TG, DTG or DSC curves) at various heating rates and permits to determine both the activation energy Eact and the reaction order of a single rate-limited step reaction with using DTA (DSC) and TG data simultaneously. deoxythymidylyl-3'-5'-deoxyadenylate 59-62 desmocollin 3 Homo sapiens 247-250 10816022-1 2000 The program makes it possible to obtain kinetics profiles (DTA, TG, DTG or DSC curves) at various heating rates and permits to determine both the activation energy Eact and the reaction order of a single rate-limited step reaction with using DTA (DSC) and TG data simultaneously. deoxythymidylyl-3'-5'-deoxyadenylate 242-245 desmocollin 3 Homo sapiens 75-78 10816022-1 2000 The program makes it possible to obtain kinetics profiles (DTA, TG, DTG or DSC curves) at various heating rates and permits to determine both the activation energy Eact and the reaction order of a single rate-limited step reaction with using DTA (DSC) and TG data simultaneously. deoxythymidylyl-3'-5'-deoxyadenylate 242-245 desmocollin 3 Homo sapiens 247-250 10470226-2 1999 The clinical significance of serum thyroid peroxidase (TPO) for differentiated thyroid carcinomas(DTA) is estimated differently. deoxythymidylyl-3'-5'-deoxyadenylate 98-101 thyroid peroxidase Homo sapiens 55-58 10470226-4 1999 For further clarification a prospective follow-up study was performed including 66 female and 14 male total thyroidectomized patients with DTA for the time course of TPO and human thyroglobulin (hTg) in relation to the ablative radioidine therapy (ART). deoxythymidylyl-3'-5'-deoxyadenylate 139-142 thyroid peroxidase Homo sapiens 166-169 10470226-9 1999 The clinical value of TPO seems to be in the time being limited to DTA due to false negative hTg values. deoxythymidylyl-3'-5'-deoxyadenylate 67-70 thyroid peroxidase Homo sapiens 22-25 10454119-7 1999 Ectopic expression of UCP1-DTA in the brain could explain the phenotype of this mouse in a manner more consistent with the results of other models with altered UCP1 and brown adipocyte expression. deoxythymidylyl-3'-5'-deoxyadenylate 27-30 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 22-26 10454119-7 1999 Ectopic expression of UCP1-DTA in the brain could explain the phenotype of this mouse in a manner more consistent with the results of other models with altered UCP1 and brown adipocyte expression. deoxythymidylyl-3'-5'-deoxyadenylate 27-30 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 160-164 9700923-6 1998 The thymines within dTC and dTA sequences showed modification indicating that these thymines display an unstacked structure allowing both probes to attack. deoxythymidylyl-3'-5'-deoxyadenylate 28-31 distal antenna Drosophila melanogaster 24-26 9575979-8 1998 Serum leptin level was elevated in UCP-DTA mice at 24 degrees C compared with control mice at 24 degrees C; this elevated level decreased within 1 day at 14 degrees C and was not different from the level in control mice by 14 days. deoxythymidylyl-3'-5'-deoxyadenylate 39-42 leptin Mus musculus 6-12 9575979-8 1998 Serum leptin level was elevated in UCP-DTA mice at 24 degrees C compared with control mice at 24 degrees C; this elevated level decreased within 1 day at 14 degrees C and was not different from the level in control mice by 14 days. deoxythymidylyl-3'-5'-deoxyadenylate 39-42 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 35-38 1467355-7 1992 According to morphological dta, cessation of CCl4 injections was accompanied by rapid regeneration of liver tissues in all animal groups. deoxythymidylyl-3'-5'-deoxyadenylate 27-30 C-C motif chemokine ligand 4 Rattus norvegicus 45-49 9389757-5 1997 Troglitazone also markedly decreased the serum levels of cholesterol, triglycerides, and free fatty acids both in wild-type and aP2/DTA mice. deoxythymidylyl-3'-5'-deoxyadenylate 132-135 transcription factor AP-2, alpha Mus musculus 128-131 9044279-7 1997 Cytosol-dependent DTA translocation is GTP gamma S-insensitive but is blocked by anti-beta COP antibodies. deoxythymidylyl-3'-5'-deoxyadenylate 18-21 COPI coat complex subunit beta 2 Homo sapiens 86-94 8628691-10 1996 To assign the 13C spectrum and establish the bond connectivities of the TA* photoproduct of TpdA [d(TpA)*], 1H-13C heteronuclear multiple-quantum coherence (HMQC) and heteronuclear multiple bond correlation (HMBC) spectra were obtained. deoxythymidylyl-3'-5'-deoxyadenylate 92-96 plasminogen activator, tissue type Homo sapiens 100-103 8631294-3 1996 Similar amounts of DTA fragment were translocated through the plasma membrane of NIH 3T3 cells transfected with the wild-type receptor (DTR), DTR-GPI and DTR-EGFR, but translocation was about six times less efficient in the case of DTR-GPI and DTR-EGFR when taking into account the number of receptors expressed. deoxythymidylyl-3'-5'-deoxyadenylate 19-22 epidermal growth factor receptor Mus musculus 158-162 8631294-3 1996 Similar amounts of DTA fragment were translocated through the plasma membrane of NIH 3T3 cells transfected with the wild-type receptor (DTR), DTR-GPI and DTR-EGFR, but translocation was about six times less efficient in the case of DTR-GPI and DTR-EGFR when taking into account the number of receptors expressed. deoxythymidylyl-3'-5'-deoxyadenylate 19-22 epidermal growth factor receptor Homo sapiens 248-252 8536614-2 1996 To test this hypothesis, we fed UCP-DTA transgenic with toxigene-mediated ablation of BAT and their control littermates a "Western diet" [21% (wt/wt) fat] or normal mouse chow [6.5% (wt/wt) fat]. deoxythymidylyl-3'-5'-deoxyadenylate 36-39 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 32-35 8536614-7 1996 These metabolic changes were accompanied by increased expression of tumor necrosis factor-alpha and decreased expression of GLUT4 and beta 3-adrenergic receptor messenger RNA levels in white adipose tissue of UCP-DTA transgenic mice receiving the Western diet compared to those in the other experimental groups. deoxythymidylyl-3'-5'-deoxyadenylate 213-216 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 124-129 8536614-7 1996 These metabolic changes were accompanied by increased expression of tumor necrosis factor-alpha and decreased expression of GLUT4 and beta 3-adrenergic receptor messenger RNA levels in white adipose tissue of UCP-DTA transgenic mice receiving the Western diet compared to those in the other experimental groups. deoxythymidylyl-3'-5'-deoxyadenylate 213-216 adrenergic receptor, beta 3 Mus musculus 134-160 8536614-7 1996 These metabolic changes were accompanied by increased expression of tumor necrosis factor-alpha and decreased expression of GLUT4 and beta 3-adrenergic receptor messenger RNA levels in white adipose tissue of UCP-DTA transgenic mice receiving the Western diet compared to those in the other experimental groups. deoxythymidylyl-3'-5'-deoxyadenylate 213-216 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 209-212 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 100-103 DEK proto-oncogene (DNA binding) Mus musculus 8-11 34838844-11 2022 Furthermore, when vision was intact, dopamine and DOPAC levels were similar between Opn4-/- and Opn4+/+ mice, but higher in Opn4DTA/DTA mice, which differed with age. deoxythymidylyl-3'-5'-deoxyadenylate 132-135 opsin 4 (melanopsin) Mus musculus 124-131 34331009-7 2021 Mice after DTA induction revealed a syndrome comprising hyperactivity, hippocampal learning/memory deficits, prefrontal cortical network dysfunction, lasting blood brain-barrier impairment, brain inflammation, mainly in hippocampal and cortical regions with pyramidal neuronal death, microgliosis, astrogliosis, modest immune cell infiltration, regional atrophy, and relative increases in parvalbumin-positive interneurons. deoxythymidylyl-3'-5'-deoxyadenylate 11-14 parvalbumin Mus musculus 389-400 34151504-12 2021 Pretreatment QA of clinical cases resulted with better than 3% point dose difference and more than 99% gamma passing rate (3% DD/2 mm DTA/10% threshold) tested with Delta4. deoxythymidylyl-3'-5'-deoxyadenylate 134-137 delta like canonical Notch ligand 4 Homo sapiens 165-171 35558158-7 2022 Mechanistically, macrophage M2 polarization attributed to the IL-4 elevation induced by Th2 immune activation in the treatment of DTA-1, resulting in DTA-1 resistance. deoxythymidylyl-3'-5'-deoxyadenylate 150-153 interleukin 4 Homo sapiens 62-66 35558158-8 2022 Furthermore, Toll-like receptor 4 (TLR4) agonist could diminish the macrophage (M2) polarization and reverse the M2-mediated DTA-1 resistance, eliciting robust antitumor effect in HCC. deoxythymidylyl-3'-5'-deoxyadenylate 125-128 toll like receptor 4 Homo sapiens 13-33 35558158-8 2022 Furthermore, Toll-like receptor 4 (TLR4) agonist could diminish the macrophage (M2) polarization and reverse the M2-mediated DTA-1 resistance, eliciting robust antitumor effect in HCC. deoxythymidylyl-3'-5'-deoxyadenylate 125-128 toll like receptor 4 Homo sapiens 35-39 35558158-9 2022 Our finding demonstrated that the TLR4 agonist synergized with DTA-1 was a potential strategy for HCC treatment. deoxythymidylyl-3'-5'-deoxyadenylate 63-67 toll like receptor 4 Homo sapiens 34-38 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 223-226 98633-1 1978 Physico-chemical study of a case of cementifying fibroma in the mandible of 78-year-old woman was carried out by X-ray diffraction analysis and thermogravimetric and differential-thermal analyses (TGA-DTA). deoxythymidylyl-3'-5'-deoxyadenylate 201-204 T-box transcription factor 1 Homo sapiens 197-200 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 interleukin 4 Mus musculus 244-248 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 interleukin 5 Mus musculus 250-254 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 interleukin 13 Mus musculus 256-261 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 interferon gamma Mus musculus 288-297 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 vimentin Mus musculus 338-346 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 actin alpha 2, smooth muscle, aorta Mus musculus 348-357 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 snail family zinc finger 1 Mus musculus 359-364 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 snail family zinc finger 2 Mus musculus 365-369 35356877-4 2022 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate 119-122 cadherin 1 Mus musculus 425-435 33253580-2 2021 Blocking DEK using the aptamer DTA via articular injection has been shown to have robust anti-inflammatory efficacy in a previous study. deoxythymidylyl-3'-5'-deoxyadenylate 31-34 DEK proto-oncogene (DNA binding) Mus musculus 9-12 33596501-3 2021 The fabricated materials exhibited relatively small (Deltatheta = 18.7 +- 2.50) contact angle and prominent hydrophilic properties, which are attributable to sulfur-enriched MoS2 composite as evidenced by simultaneous thermal analysis (STA) coupled with mass spectrometric (MS) analysis of evolving gaseous species (TG/DTA-MS) analysis. deoxythymidylyl-3'-5'-deoxyadenylate 319-322 Mic26p Saccharomyces cerevisiae S288C 174-178 28448900-5 2017 XRD and TG-DTA confirms the presence of magnetic nanoparticles loaded onto MCP nanogel. deoxythymidylyl-3'-5'-deoxyadenylate 11-14 capping actin protein, gelsolin like Homo sapiens 75-78 28732025-3 2017 Using an LV-specific Cre allele (Hand1LV-Cre), we ablate Hand1-lineage cardiomyocytes, revealing that DTA-mediated cardiomyocyte death results in a hypoplastic LV by E10.5. deoxythymidylyl-3'-5'-deoxyadenylate 102-105 heart and neural crest derivatives expressed 1 Mus musculus 33-38 28732025-3 2017 Using an LV-specific Cre allele (Hand1LV-Cre), we ablate Hand1-lineage cardiomyocytes, revealing that DTA-mediated cardiomyocyte death results in a hypoplastic LV by E10.5. deoxythymidylyl-3'-5'-deoxyadenylate 102-105 heart and neural crest derivatives expressed 1 Mus musculus 57-62 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 transforming growth factor, beta 1 Mus musculus 79-88 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 vimentin Homo sapiens 194-202 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 actin alpha 1, skeletal muscle Homo sapiens 207-216 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 matrix metallopeptidase 2 Homo sapiens 265-270 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 matrix metallopeptidase 9 Homo sapiens 275-280 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 RELA proto-oncogene, NF-kB subunit Homo sapiens 286-299 33007157-7 2020 Accordingly, D-TA COF film was applied as the photoactive material to build a PEC biosensor for H2O2 detection based on coupling with large amounts of catalase (CAT) through simple adsorption. deoxythymidylyl-3'-5'-deoxyadenylate 13-17 catalase Homo sapiens 151-159 33007157-7 2020 Accordingly, D-TA COF film was applied as the photoactive material to build a PEC biosensor for H2O2 detection based on coupling with large amounts of catalase (CAT) through simple adsorption. deoxythymidylyl-3'-5'-deoxyadenylate 13-17 catalase Homo sapiens 161-164 32276642-15 2020 Compared to DTA- mice, ELISA revealed significantly lower IL-10 and TGF-beta levels in both male and female DTA+ mice under both normal conditions and after HI (more pronounced). deoxythymidylyl-3'-5'-deoxyadenylate 108-111 interleukin 10 Mus musculus 58-63 32276642-15 2020 Compared to DTA- mice, ELISA revealed significantly lower IL-10 and TGF-beta levels in both male and female DTA+ mice under both normal conditions and after HI (more pronounced). deoxythymidylyl-3'-5'-deoxyadenylate 108-111 transforming growth factor alpha Mus musculus 68-76 29601269-8 2018 The detection of persistent DTA mutations (i.e., mutations in DNMT3A, TET2, and ASXL1), which are often present in persons with age-related clonal hematopoiesis, was not correlated with an increased relapse rate. deoxythymidylyl-3'-5'-deoxyadenylate 28-31 ASXL transcriptional regulator 1 Homo sapiens 80-85 29019279-8 2018 However, gene expression of adiponectin and leptin in RPAT was only increased by RT (DTA and DTL) compared with DA and DL by approximately 93% ( p<.0001) and 78% ( p=.0002), respectively. deoxythymidylyl-3'-5'-deoxyadenylate 85-88 adiponectin, C1Q and collagen domain containing Rattus norvegicus 28-39 29019279-9 2018 Similarly, the levels of adiponectin in the serum, tissue IL-10 (RPAT) and serum IL-10 were only increased in DTA and DTL compared with DA and DL by approximately 31% ( p=.03), 45% ( p=.0009) and 35% ( p=.003), respectively. deoxythymidylyl-3'-5'-deoxyadenylate 110-113 adiponectin, C1Q and collagen domain containing Rattus norvegicus 25-36 29019279-9 2018 Similarly, the levels of adiponectin in the serum, tissue IL-10 (RPAT) and serum IL-10 were only increased in DTA and DTL compared with DA and DL by approximately 31% ( p=.03), 45% ( p=.0009) and 35% ( p=.003), respectively. deoxythymidylyl-3'-5'-deoxyadenylate 110-113 interleukin 10 Rattus norvegicus 58-63 29019279-9 2018 Similarly, the levels of adiponectin in the serum, tissue IL-10 (RPAT) and serum IL-10 were only increased in DTA and DTL compared with DA and DL by approximately 31% ( p=.03), 45% ( p=.0009) and 35% ( p=.003), respectively. deoxythymidylyl-3'-5'-deoxyadenylate 110-113 interleukin 10 Rattus norvegicus 81-86 28259624-5 2017 Enhanced thermal stability of this material was ascertained by TGA-DTA studies. deoxythymidylyl-3'-5'-deoxyadenylate 67-70 T-box transcription factor 1 Homo sapiens 63-66 28377614-3 2017 Here we investigated the role of Hsp90 and its co-chaperones during the uptake of native diphtheria toxin into human cells and identified the components of the Hsp90 machinery including Hsp90, Hsp70, Cyp40 and the FK506 binding proteins FKBP51 and FKBP52 as DTA binding partners. deoxythymidylyl-3'-5'-deoxyadenylate 258-261 heat shock protein 90 alpha family class A member 1 Homo sapiens 160-165 28412645-5 2017 A detailed bilayered analysis of the wall mechanics predicted, however, that the adventitia of TSP2-null DTAs fails to engage at high pressures, which could render the media vulnerable to mechanical damage. deoxythymidylyl-3'-5'-deoxyadenylate 105-109 thrombospondin 2 Mus musculus 95-99 28412645-9 2017 Combined with the observed microstructural anomalies, our theoretical-experimental biomechanical results suggest that TSP2-null DTAs are more susceptible to material failure when exposed to high pressures and this vulnerability may result from a reduced resistance to shear loading at the medial/adventitial border. deoxythymidylyl-3'-5'-deoxyadenylate 128-132 thrombospondin 2 Mus musculus 118-122 28236682-9 2017 Thermal stability of the synthesized complex has determined by TGA-DTA analysis. deoxythymidylyl-3'-5'-deoxyadenylate 67-70 T-box transcription factor 1 Homo sapiens 63-66 28377614-3 2017 Here we investigated the role of Hsp90 and its co-chaperones during the uptake of native diphtheria toxin into human cells and identified the components of the Hsp90 machinery including Hsp90, Hsp70, Cyp40 and the FK506 binding proteins FKBP51 and FKBP52 as DTA binding partners. deoxythymidylyl-3'-5'-deoxyadenylate 258-261 heat shock protein 90 alpha family class A member 1 Homo sapiens 160-165 28377614-4 2017 Moreover, pharmacological inhibition of the chaperone activity of Hsp90 and Hsp70 and of the peptidyl-prolyl cis/trans isomerase (PPIase) activity of Cyps and FKBPs protected cells from intoxication with diphtheria toxin and inhibited the pH-dependent trans-membrane transport of DTA into the cytosol. deoxythymidylyl-3'-5'-deoxyadenylate 280-283 FKBP prolyl isomerase 4 Homo sapiens 93-128 28377614-4 2017 Moreover, pharmacological inhibition of the chaperone activity of Hsp90 and Hsp70 and of the peptidyl-prolyl cis/trans isomerase (PPIase) activity of Cyps and FKBPs protected cells from intoxication with diphtheria toxin and inhibited the pH-dependent trans-membrane transport of DTA into the cytosol. deoxythymidylyl-3'-5'-deoxyadenylate 280-283 FKBP prolyl isomerase 4 Homo sapiens 130-136 30160407-11 2017 A little SC2 contained into TBzDT was revealed by FTIR, TG-DTA from different sides. deoxythymidylyl-3'-5'-deoxyadenylate 59-62 trans-2,3-enoyl-CoA reductase Homo sapiens 9-12 26841833-3 2016 A novel dual target-directed agent (DTA(A7/sTNFR2)) was generated by conjugating soluble TNF receptor 2 (sTNFR2) to the Fc region of A7, a new anti-IL-6R antibody obtained by screening the phage display human antibody library. deoxythymidylyl-3'-5'-deoxyadenylate 36-39 interleukin 6 receptor Homo sapiens 148-153 27602499-7 2016 In contrast, after intravenous administration of B16.F10 cells, melanoma colonization of the lungs was markedly reduced in Mcpt5-Cre+ R-DTA+ vs. Mcpt5-Cre- R-DTA+ animals. deoxythymidylyl-3'-5'-deoxyadenylate 136-139 chymase 1, mast cell Mus musculus 123-128 27602499-8 2016 Decreased melanoma colonization of the lungs in Mcpt5-Cre+ R-DTA+ animals was accompanied by increased inflammatory cell recruitment into the bronchoalveolar lavage fluid, suggesting that mast cells suppress inflammation in this setting. deoxythymidylyl-3'-5'-deoxyadenylate 61-64 chymase 1, mast cell Mus musculus 48-53 27602499-9 2016 Further, qPCR analysis revealed significant alterations in the expression of Twist and E-cadherin in lungs of Mcpt5-Cre+ R-DTA+ vs. control Mcpt5-Cre- R-DTA+ animals, suggesting an impact of mast cells on epithelial-mesenchymal transition. deoxythymidylyl-3'-5'-deoxyadenylate 123-126 cadherin 1 Mus musculus 87-97 27602499-9 2016 Further, qPCR analysis revealed significant alterations in the expression of Twist and E-cadherin in lungs of Mcpt5-Cre+ R-DTA+ vs. control Mcpt5-Cre- R-DTA+ animals, suggesting an impact of mast cells on epithelial-mesenchymal transition. deoxythymidylyl-3'-5'-deoxyadenylate 123-126 chymase 1, mast cell Mus musculus 110-115 27602499-9 2016 Further, qPCR analysis revealed significant alterations in the expression of Twist and E-cadherin in lungs of Mcpt5-Cre+ R-DTA+ vs. control Mcpt5-Cre- R-DTA+ animals, suggesting an impact of mast cells on epithelial-mesenchymal transition. deoxythymidylyl-3'-5'-deoxyadenylate 153-156 cadherin 1 Mus musculus 87-97 27428999-3 2016 Here, DTA ADP-ribosylates elongation factor 2 inhibits protein synthesis and leads to cell death. deoxythymidylyl-3'-5'-deoxyadenylate 6-9 eukaryotic translation elongation factor 2 Homo sapiens 26-45 25911959-2 2016 In vitro, thioredoxin reduces this disulfide and thioredoxin reductase (TrxR) is part of a cytosolic complex facilitating DTA-translocation. deoxythymidylyl-3'-5'-deoxyadenylate 122-125 thioredoxin Homo sapiens 10-21 25911959-2 2016 In vitro, thioredoxin reduces this disulfide and thioredoxin reductase (TrxR) is part of a cytosolic complex facilitating DTA-translocation. deoxythymidylyl-3'-5'-deoxyadenylate 122-125 peroxiredoxin 5 Homo sapiens 49-70 25911959-2 2016 In vitro, thioredoxin reduces this disulfide and thioredoxin reductase (TrxR) is part of a cytosolic complex facilitating DTA-translocation. deoxythymidylyl-3'-5'-deoxyadenylate 122-125 peroxiredoxin 5 Homo sapiens 72-76 25911959-3 2016 We found that the TrxR-specific inhibitor auranofin prevented DTA delivery into the cytosol and intoxication of HeLa cells with diphtheria toxin, offering perspectives for novel pharmacological strategies against diphtheria. deoxythymidylyl-3'-5'-deoxyadenylate 62-65 peroxiredoxin 5 Homo sapiens 18-22 27155437-3 2016 The evolution of photolysis, Fenton-like reaction, thermal treatments, and solvent extractions and the occurrence in the zeolite pores of organic residues eventually entrapped was elucidated by a combined thermogravimetric (TGA-DTA), diffractometric (XRPD), and spectroscopic (FT-IR) approach. deoxythymidylyl-3'-5'-deoxyadenylate 228-231 T-box transcription factor 1 Homo sapiens 224-227 27459098-7 2016 DTA injury induced the expansion of Sall1gfp(+) microglia, whereas Ly6C(+) monocyte-derived macrophages were mostly Sall1gfp(-) , supporting the idea that Sall1 is exclusively expressed in microglia within the retinal phagocyte pool. deoxythymidylyl-3'-5'-deoxyadenylate 0-3 spalt like transcription factor 1 Mus musculus 36-41 27027302-6 2016 Interestingly, mice infected and treated with an agonistic antibody anti-GITR (DTA-1) presented a robust increase in pro-inflammatory cytokine production at preferential sites of parasite replication, which was associated with the decrease in latent brain parasitism of mice under treatment with DTA-1. deoxythymidylyl-3'-5'-deoxyadenylate 79-82 tumor necrosis factor receptor superfamily, member 18 Mus musculus 73-77 24239761-3 2014 Cu(II), Co(II) and Ni(II) complexes of the prepared ligands have been synthesized and characterized by various spectroscopic techniques like IR, UV-Visible as well as magnetic and thermal (TG and DTA) measurements. deoxythymidylyl-3'-5'-deoxyadenylate 196-199 mitochondrially encoded cytochrome c oxidase II Homo sapiens 8-14 26071358-9 2015 DTA expression in mTas2r105 + cells completely ablate the expression of mTas2r105 in intestinal epithelia, but did not ablate mTas1r3 expression in intestine epithelia. deoxythymidylyl-3'-5'-deoxyadenylate 0-3 taste receptor, type 2, member 105 Mus musculus 18-27 26071358-9 2015 DTA expression in mTas2r105 + cells completely ablate the expression of mTas2r105 in intestinal epithelia, but did not ablate mTas1r3 expression in intestine epithelia. deoxythymidylyl-3'-5'-deoxyadenylate 0-3 taste receptor, type 2, member 105 Mus musculus 72-81 25756686-2 2015 Besides photoluminescence studies thermal stability for the LZP glass is also evaluated from TG-DTA measurement. deoxythymidylyl-3'-5'-deoxyadenylate 96-99 oncoprotein induced transcript 3 Homo sapiens 60-63 25490270-4 2014 Using both lineage-specific and ubiquitous reporter alleles, we show that the remaining muscles in Myf5(Cre)-DTA embryos arise mainly from Myf5(+) escaper cells. deoxythymidylyl-3'-5'-deoxyadenylate 109-112 myogenic factor 5 Homo sapiens 99-103 25490270-4 2014 Using both lineage-specific and ubiquitous reporter alleles, we show that the remaining muscles in Myf5(Cre)-DTA embryos arise mainly from Myf5(+) escaper cells. deoxythymidylyl-3'-5'-deoxyadenylate 109-112 myogenic factor 5 Homo sapiens 139-143 24558202-6 2014 Transfer of serum antibodies from DTA-1-treated mice, which contain high levels of DTA-1-specific immunoglobulin G1 (IgG1), can induce anaphylaxis in naive mice upon administration of an additional dose of DTA-1, suggesting that anaphylaxis results from anti-DTA-1 antibodies. deoxythymidylyl-3'-5'-deoxyadenylate 34-37 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 117-121 22925975-8 2012 The thermal characteristic of the sample was analysed by TGA-DTA techniques, and the sample was found to be thermally stable up to 280 C. The kinetic and thermodynamic parameters were also determined. deoxythymidylyl-3'-5'-deoxyadenylate 61-64 T-box transcription factor 1 Homo sapiens 57-60 24019552-3 2013 This subset was ablated in huLangerin-DTA mice, resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. deoxythymidylyl-3'-5'-deoxyadenylate 38-41 negative elongation factor complex member C/D, Th1l Mus musculus 72-75 23993507-1 2013 A novel Pb(II) ion imprinted polymer coated on magnetic mesoporous silica was synthesised and characterised by scanning electron microscopy (SEM), thermal gravimetric/differential thermal analysis (TG/DTA), elemental analysis (CHN) and low angle X-ray powder diffraction (XRD). deoxythymidylyl-3'-5'-deoxyadenylate 201-204 submaxillary gland androgen regulated protein 3B Homo sapiens 8-14 24061374-9 2012 The experimental results of TG-DTA showed that the Co(III) complex contained ethanol and crystal water in the first two stages. deoxythymidylyl-3'-5'-deoxyadenylate 31-34 mitochondrially encoded cytochrome c oxidase III Homo sapiens 51-58 22402478-5 2012 TG-DTA studies show the decomposition temperatures to be 255 C, 232 C, 258 C and 264 C for pure, LA, Gly and LT doped KAP crystals respectively. deoxythymidylyl-3'-5'-deoxyadenylate 3-6 napsin A aspartic peptidase Homo sapiens 122-125 22714024-3 2012 The compound Cs-1 was characterized by elemental analysis, thermogravimetric/differential thermal analysis (TG/DTA), Fourier transform infrared (FTIR) and UV-visible spectroscopy, solution (1)H and (31)P nuclear magnetic resonance (NMR), and X-ray crystallography. deoxythymidylyl-3'-5'-deoxyadenylate 111-114 chorionic somatomammotropin hormone 1 Homo sapiens 13-17 21737219-6 2011 In addition, the thermal decomposition of cyanoacrylate was studied using simultaneous thermogravimetric and differential thermal analysis (TGA-DTA). deoxythymidylyl-3'-5'-deoxyadenylate 144-147 T-box transcription factor 1 Homo sapiens 140-143 22233932-4 2012 Summit metabolism ( V O2summit) and norepinephrine-induced thermogenesis ( V O2NST) were significantly lower in UCP-dta mice relative to wild-type mice regardless of temperature treatment, but both were significantly higher in cold relative to warm acclimated mice. deoxythymidylyl-3'-5'-deoxyadenylate 116-119 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 112-115 21874233-6 2011 All of the tumors treated with the control vector increased in size, whereas 35.7% of the tumors in the groups treated with a total amount of 2.5 mg DTA-H19 plasmid shrank in size. deoxythymidylyl-3'-5'-deoxyadenylate 149-152 H19 imprinted maternally expressed transcript Homo sapiens 153-156 20927785-3 2010 In the presence of the clinically significant TEM-1 beta-lactamase, the DTA-antibiotic complex on the solid beads is hydrolyzed, thus releasing the DTA dye into solution. deoxythymidylyl-3'-5'-deoxyadenylate 72-75 CD248 molecule Homo sapiens 46-51 21536899-3 2011 In these mice, tamoxifen-inducible Cre recombinase allows the NSE (Eno2) gene to drive DTA expression in differentiating neurons, leading to the efficient ablation of newly born neurons in the forebrain. deoxythymidylyl-3'-5'-deoxyadenylate 87-90 enolase 2, gamma neuronal Mus musculus 62-65 21536899-3 2011 In these mice, tamoxifen-inducible Cre recombinase allows the NSE (Eno2) gene to drive DTA expression in differentiating neurons, leading to the efficient ablation of newly born neurons in the forebrain. deoxythymidylyl-3'-5'-deoxyadenylate 87-90 enolase 2, gamma neuronal Mus musculus 67-71 21345718-2 2011 The thermal study (TGA-DTA) provided evidence for weakly bound ethanol which is readily substituted by neutral N-donor molecule imidazole, benzimidazole or pyridine to produce an array of newer complexes, [Fe(L(n))(acac)X] (n=1, 2; X=Im, Bim, Py). deoxythymidylyl-3'-5'-deoxyadenylate 23-26 T-box transcription factor 1 Homo sapiens 19-22 21714265-7 2011 TGA analysis showed that the heat resistance of modified wood increased, the three exothermic peaks in DTA curve of modified wood were 280, 360 and 485 degrees C which were higher than natural wood in the corresponding position FTIR analysis showed that the hydroxyl modified material has a good association phenomenon, and carbonyl content decreased. deoxythymidylyl-3'-5'-deoxyadenylate 103-106 T-box transcription factor 1 Homo sapiens 0-3 20946244-6 2011 Both inhibitors, as well as an antibody against cyclophilin A blocked the release of active LF(N)DTA from endosomal vesicles into the cytosol in vitro. deoxythymidylyl-3'-5'-deoxyadenylate 97-100 peptidyl-prolyl cis-trans isomerase A Cricetulus griseus 48-61 20946244-8 2011 In vitro, cyclophilin A and Hsp90 bound to LF(N)DTA and DTA but not to LF, implying that DTA determines this interaction. deoxythymidylyl-3'-5'-deoxyadenylate 48-51 peptidyl-prolyl cis-trans isomerase A Cricetulus griseus 10-23 20946244-8 2011 In vitro, cyclophilin A and Hsp90 bound to LF(N)DTA and DTA but not to LF, implying that DTA determines this interaction. deoxythymidylyl-3'-5'-deoxyadenylate 56-59 peptidyl-prolyl cis-trans isomerase A Cricetulus griseus 10-23 20946244-8 2011 In vitro, cyclophilin A and Hsp90 bound to LF(N)DTA and DTA but not to LF, implying that DTA determines this interaction. deoxythymidylyl-3'-5'-deoxyadenylate 56-59 peptidyl-prolyl cis-trans isomerase A Cricetulus griseus 10-23 20946244-9 2011 In conclusion, cyclophilin A and Hsp90 facilitate translocation of LF(N)DTA, but not of LF, across endosomal membranes, and thus they function selectively in promoting translocation of certain proteins, but not of others. deoxythymidylyl-3'-5'-deoxyadenylate 72-75 peptidyl-prolyl cis-trans isomerase A Cricetulus griseus 15-28 21482644-11 2011 Additionally, corneas from huLangerin-DTA mice were devoid of Langerin+ cells in the epithelium but were detectable in the stroma. deoxythymidylyl-3'-5'-deoxyadenylate 38-41 CD207 antigen Mus musculus 29-37 20927785-3 2010 In the presence of the clinically significant TEM-1 beta-lactamase, the DTA-antibiotic complex on the solid beads is hydrolyzed, thus releasing the DTA dye into solution. deoxythymidylyl-3'-5'-deoxyadenylate 148-151 CD248 molecule Homo sapiens 46-51 19158956-0 2009 Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice. deoxythymidylyl-3'-5'-deoxyadenylate 46-49 mucin 5, subtypes A and C, tracheobronchial/gastric Mus musculus 39-45 20352824-7 2010 In order to confirm the formation of MgB2 phase, DTA was used as heating rate of 10 degrees C/min at Ar atmosphere from room temperature to 1200 degrees C. In the PPMS result, the Tc (critical temperature) was about 21 K, and the density of spark plasma sintered samples increased to 1.87 g/cm3 by increasing sintering temperature. deoxythymidylyl-3'-5'-deoxyadenylate 49-52 secretoglobin family 2A member 1 Homo sapiens 37-41 19787680-10 2009 Taking ITA haplotype as reference, multivariate regression analysis confirmed the negative (ITG), and positive (DCG, DTG, DCA and DTA) association of specific ACE haplotypes with DN, after adjusting for potential nephropathy-linked covariates. deoxythymidylyl-3'-5'-deoxyadenylate 130-133 angiotensin I converting enzyme Homo sapiens 159-162 19656414-7 2009 Intratumoral injection of DTA-H19 into ectopically developed tumors caused 40% inhibition of tumor growth. deoxythymidylyl-3'-5'-deoxyadenylate 26-29 H19 imprinted maternally expressed transcript Homo sapiens 30-33 19643734-3 2009 The promoter sequences of two genes that are highly active in ovarian tumor cells, MSLN and HE4, were used to target DT-A expression to tumor cells. deoxythymidylyl-3'-5'-deoxyadenylate 117-121 mesothelin Mus musculus 83-87 19643734-3 2009 The promoter sequences of two genes that are highly active in ovarian tumor cells, MSLN and HE4, were used to target DT-A expression to tumor cells. deoxythymidylyl-3'-5'-deoxyadenylate 117-121 WAP four-disulfide core domain 2 Mus musculus 92-95 17996335-1 2008 Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements. deoxythymidylyl-3'-5'-deoxyadenylate 171-174 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-6