PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11163049-3	2001	Iganidipine (0.0001% to 0.1%) was instilled into eyes with impaired ocular circulation before or after the intravitreal injection of endothelin-1, and the change in ONH blood flow was measured.	iganidipine	0-11	endothelin-1	Oryctolagus cuniculus	133-145
15370369-0	2004	Topical administration of iganidipine, a new water-soluble Ca2+ antagonist, increases ipsilateral optic nerve head circulation in rabbits and cynomolgus monkeys.	iganidipine	26-37	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
9270081-6	1997	Iganidipine at all doses examined increased the urinary prostaglandin (PG) I2 and PGE2, but not PGF2alpha or thromboxane B2, and decreased plasma angiotensin II (AII) level and renin activity.	iganidipine	0-11	angiotensinogen	Rattus norvegicus	146-160
11341901-3	2001	(2) Iganidipine (0.0001%-0.1%) was instilled into a circulation-disordered eye before or after the intravitreal injection of endothelin-1, and change in the blood flow in the ONH was measured.	iganidipine	4-15	endothelin-1	Oryctolagus cuniculus	125-137
10979293-6	2000	Iganidipine (0.0001%-0.1%) was instilled into a circulation-disordered eye before or after the intravitreal injection of endothelin-1, and change in the blood flow in the ONH was measured.	iganidipine	0-11	endothelin-1	Oryctolagus cuniculus	121-133
10617910-0	2000	Improving effects of topical administration of iganidipine, a new calcium channel blocker, on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits.	iganidipine	47-58	endothelin-1	Oryctolagus cuniculus	137-149
10617910-1	2000	PURPOSE: To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits.	iganidipine	46-57	endothelin-1	Oryctolagus cuniculus	167-179
10617910-1	2000	PURPOSE: To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits.	iganidipine	46-57	endothelin-1	Oryctolagus cuniculus	181-185
10617910-3	2000	Then modification of the effect of ET-1 on the VEP by iganidipine was examined.	iganidipine	54-65	endothelin-1	Oryctolagus cuniculus	35-39
10617910-4	2000	One hour after the topical instillation of 0.1% iganidipine (20 microl) or its vehicle, 10 pmol of ET-1 was injected into the vitreous in rabbits.	iganidipine	48-59	endothelin-1	Oryctolagus cuniculus	99-103
10617910-7	2000	Topical administration of 0.1% iganidipine significantly suppressed the reduction of VEP amplitude for the entire 2-hour monitoring period after intravitreal injection of 10 pmol ET-1.	iganidipine	31-42	endothelin-1	Oryctolagus cuniculus	179-183
10617910-9	2000	CONCLUSIONS: Iganidipine eyedrops may be useful for the treatment of ischemic retinal and optic nerve disorders related to abnormal ET-1 production for the maintenance of visual function.	iganidipine	13-24	endothelin-1	Oryctolagus cuniculus	132-136
9270081-6	1997	Iganidipine at all doses examined increased the urinary prostaglandin (PG) I2 and PGE2, but not PGF2alpha or thromboxane B2, and decreased plasma angiotensin II (AII) level and renin activity.	iganidipine	0-11	angiotensinogen	Rattus norvegicus	162-165
9270081-6	1997	Iganidipine at all doses examined increased the urinary prostaglandin (PG) I2 and PGE2, but not PGF2alpha or thromboxane B2, and decreased plasma angiotensin II (AII) level and renin activity.	iganidipine	0-11	renin	Rattus norvegicus	177-182
9270081-11	1997	In addition to the reduced blood pressure, the reduction of plasma AII and the increase of vasodilatory prostanoids may also partially contribute to the renal and cerebral protective effects of iganidipine.	iganidipine	194-205	angiotensinogen	Rattus norvegicus	67-70