PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33379147-3	2020	METHOD: The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions in the biosynthetic pathway of CoQ.	coq	185-188	coenzyme Q2, polyprenyltransferase	Homo sapiens	98-102
669987-3	1978	The image of actual concentration of SDH in the neuropil of the molecular layer could only be recorded by adding CoQ10, while other structures exhibited greater balance between SDH and endogenous mitochondrial CoQ.	coq	113-116	serine dehydratase	Rattus norvegicus	37-40
33757970-5	2021	The lipid CoQ and mitochondrial complex IV, whose biogenesis are lipid-dependent, were found decreased after chemerin inhibition, contributing to lipid reactive oxygen species production.	coq	10-13	retinoic acid receptor responder 2	Homo sapiens	109-117
33379147-7	2020	In CoQ depleted cells, the glycolysis was upregulated together with increased glucose consumption, overexpression of GLUT1 and GLUT3, as well as activation of pyruvate kinase (PK).	coq	3-6	solute carrier family 2 member 1	Homo sapiens	117-122
33379147-7	2020	In CoQ depleted cells, the glycolysis was upregulated together with increased glucose consumption, overexpression of GLUT1 and GLUT3, as well as activation of pyruvate kinase (PK).	coq	3-6	solute carrier family 2 member 3	Homo sapiens	127-132
32637615-6	2020	Furthermore, the expression of AOX in cells and mice confirms that CI-CIII superassembly segments the CoQ in two pools and modulates CI-NADH oxidative capacity.	coq	102-105	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	31-34
32975579-5	2020	Here, using biased and unbiased approaches, we show that supraphysiological levels of CoQ10 induces an increase in the expression of SQOR in skin fibroblasts from control subjects and patients with mutations in Complex I subunits genes or CoQ biosynthetic genes.	coq	86-89	sulfide quinone oxidoreductase	Homo sapiens	133-137
31325447-5	2019	COQ4 encodes a key structural component for stabilizing the multienzymatic CoQ biosynthesis complex.	coq	75-78	coenzyme Q4	Homo sapiens	0-4
32381600-10	2020	Thus, ADCK4 knockout decreased the COQ complex level, but overexpression of ADCK4 in ADCK4-knockout podocytes transfected with wild-type ADCK4 rescued the COQ5 level.	coq	35-38	coenzyme Q8B	Mus musculus	6-11
32381602-0	2020	Mitochondria Matters: A Critical Role of ADCK4 in Stabilizing the CoQ Complex in Podocytes in Steroid-Resistant Nephrotic Syndrome.	coq	66-69	coenzyme Q8B	Homo sapiens	41-46
30661980-4	2019	We show that COQ9 repurposes the bacterial TetR fold to bind aromatic isoprenes with high specificity, including CoQ intermediates that likely reside entirely within the bilayer.	coq	113-116	coenzyme Q9	Homo sapiens	13-17
28552678-10	2017	Supplementation of cell lines with synthetic CoQ precursor compounds demonstrated beneficial effects of 2,4-dihydroxybenzoic acid in COQ7 and COQ9 deficiency.	coq	45-48	coenzyme Q7, hydroxylase	Homo sapiens	133-137
30737270-2	2019	We recently reported that individuals with mutations in COQ6, a coenzyme Q (also called CoQ10, CoQ, or ubiquinone) biosynthesis pathway enzyme, develop SRNS with sensorineural deafness, and demonstrated the beneficial effect of CoQ for maintenace of kidney function.	coq	88-91	coenzyme Q6 monooxygenase	Mus musculus	56-60
30737270-2	2019	We recently reported that individuals with mutations in COQ6, a coenzyme Q (also called CoQ10, CoQ, or ubiquinone) biosynthesis pathway enzyme, develop SRNS with sensorineural deafness, and demonstrated the beneficial effect of CoQ for maintenace of kidney function.	coq	95-98	coenzyme Q6 monooxygenase	Mus musculus	56-60
30595243-3	2018	In the present study, we examine the association between cytochrome P450 3A5*3 (CYP3A5*3) T>C (rs776746), COQ G>C (rs4693075), and SLCO1B1 T>C (rs4149056) genetic variants with the risk of myopathy in South Indian patients on statin therapy.	coq	109-112	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	80-86
29851009-2	2018	mGPDH converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane.	coq	171-174	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	0-5
28736527-0	2017	Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome.	coq	123-126	ubiquinone biosynthesis protein COQ9	Saccharomyces cerevisiae S288C	6-10
28736527-0	2017	Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome.	coq	123-126	ubiquinone biosynthesis protein COQ9	Saccharomyces cerevisiae S288C	21-25
28736527-1	2017	Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA) in yeast.	coq	88-91	ubiquinone biosynthesis protein COQ9	Saccharomyces cerevisiae S288C	0-4
28736527-9	2017	These findings suggest that human COQ9 rescues the yeast coq9 temperature-sensitive mutant by stabilizing the CoQ-synthome and increasing Q biosynthesis from 4HB.	coq	110-113	coenzyme Q9	Homo sapiens	34-38
28736527-9	2017	These findings suggest that human COQ9 rescues the yeast coq9 temperature-sensitive mutant by stabilizing the CoQ-synthome and increasing Q biosynthesis from 4HB.	coq	110-113	ubiquinone biosynthesis protein COQ9	Saccharomyces cerevisiae S288C	57-61
28552678-4	2017	This CoQ precursor is processed at the level of COQ7 and COQ9.	coq	5-8	coenzyme Q7, hydroxylase	Homo sapiens	48-52
28552678-4	2017	This CoQ precursor is processed at the level of COQ7 and COQ9.	coq	5-8	coenzyme Q9	Homo sapiens	57-61
21703546-3	2011	The genes (COQ1-9) involved in CoQ biosynthesis have been characterized in yeast.	coq	31-34	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	11-17
28357388-10	2017	This finding suggests an additional Ptc7 function beyond the regulation of CoQ biosynthesis.	coq	75-78	type 2C protein phosphatase PTC7	Saccharomyces cerevisiae S288C	36-40
26111777-4	2015	Diminished expression of the enzymes responsible for CoQ production, Pdss2 and Coq6, was observed in oocytes of older females in both mouse and human.	coq	53-56	prenyl (solanesyl) diphosphate synthase, subunit 2	Mus musculus	69-74
26111777-4	2015	Diminished expression of the enzymes responsible for CoQ production, Pdss2 and Coq6, was observed in oocytes of older females in both mouse and human.	coq	53-56	coenzyme Q6 monooxygenase	Mus musculus	79-83
25976310-4	2015	The bioenergetics defect in AOA1-mutant fibroblasts and APTX-depleted Hela cells is caused by decreased expression of SDHA and genes encoding CoQ biosynthetic enzymes, in association with reductions of APE1, NRF1 and NRF2.	coq	142-145	aprataxin	Homo sapiens	56-60
26251450-1	2015	UbiG and Coq3 (orthologue in eukaryotes) are SAM-MTases (S-adenosylmethionine-dependent methyltransferases) that catalyse both O-methylation steps in CoQ biosynthesis from prokaryotes to eukaryotes.	coq	150-153	hexaprenyldihydroxybenzoate methyltransferase	Saccharomyces cerevisiae S288C	9-13
25802402-4	2015	Coq9(R239X) mice manifest severe widespread CoQ deficiency associated with fatal encephalomyopathy and respond to 2,4-diHB increasing CoQ levels.	coq	44-47	coenzyme Q9	Mus musculus	0-4
25802402-6	2015	We show that these differences are due to the levels of COQ biosynthetic proteins, suggesting that the presence of a truncated version of COQ9 protein in Coq9(R239X) mice destabilizes the CoQ multiprotein complex.	coq	56-59	coenzyme Q9	Mus musculus	138-142
25802402-6	2015	We show that these differences are due to the levels of COQ biosynthetic proteins, suggesting that the presence of a truncated version of COQ9 protein in Coq9(R239X) mice destabilizes the CoQ multiprotein complex.	coq	56-59	coenzyme Q9	Mus musculus	154-158
24406904-0	2014	Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants.	coq	140-143	protein kinase COQ8	Saccharomyces cerevisiae S288C	59-63
23011409-9	2013	Treatment with topical CoQ(10) has a positive effect in restoring SBP anatomy and ocular surface stability.	coq	23-26	selenium binding protein 1	Homo sapiens	66-69
22529290-6	2012	CoQ(10) preincubation of healthy monocytes before IgG-antiphospholipid antibody treatment decreased oxidative stress, the percentage of cells with altered mitochondrial membrane potential, and the induced expression of tissue factor, VEGF, and Flt1.	coq	0-3	vascular endothelial growth factor A	Homo sapiens	234-238
22529290-6	2012	CoQ(10) preincubation of healthy monocytes before IgG-antiphospholipid antibody treatment decreased oxidative stress, the percentage of cells with altered mitochondrial membrane potential, and the induced expression of tissue factor, VEGF, and Flt1.	coq	0-3	fms related receptor tyrosine kinase 1	Homo sapiens	244-248
22529290-7	2012	In addition, CoQ(10) significantly improved the ultrastructural preservation of mitochondria and prevented IgG-APS-induced fission mediated by Drp-1 and Fis-1 proteins.	coq	13-16	collapsin response mediator protein 1	Homo sapiens	143-148
22529290-7	2012	In addition, CoQ(10) significantly improved the ultrastructural preservation of mitochondria and prevented IgG-APS-induced fission mediated by Drp-1 and Fis-1 proteins.	coq	13-16	fission, mitochondrial 1	Homo sapiens	153-158
19960455-5	2010	Indeed, Q(10)H(2) supplementation was more effective than Q(10) to increase levels of CoQ(10) in the liver of SAMP1 mice.	coq	86-89	transmembrane protein 201	Mus musculus	110-115
21448659-11	2011	We found that the combination of CoQ and creatine together produced additive neuroprotective effects in a chronic MPTP model, and it blocked the development of alpha-synuclein aggregates.	coq	33-36	synuclein, alpha	Mus musculus	160-175
18717628-5	2009	Elevated PD cybrid alpha-synuclein oligomer levels were also attenuated by CoQ(10) and GSH.	coq	75-78	synuclein alpha	Homo sapiens	19-34
20199352-2	2010	We have investigated if IL-6 and IL-18 levels were related to coenzyme Q(10) (CoQ(10)), an antioxidant and a marker of oxidative stress in the plasma from normotensive and preeclamptic pregnancies.	coq	78-81	interleukin 6	Homo sapiens	24-28
20199352-2	2010	We have investigated if IL-6 and IL-18 levels were related to coenzyme Q(10) (CoQ(10)), an antioxidant and a marker of oxidative stress in the plasma from normotensive and preeclamptic pregnancies.	coq	78-81	interleukin 18	Homo sapiens	33-38
20199352-8	2010	However, in PE, IL-18 level was positively correlated with the reduced form of CoQ(10) (r = 0.3680, p = 0.0495).	coq	79-82	interleukin 18	Homo sapiens	16-21
20199352-9	2010	CONCLUSION: This is the first demonstration that IL-18 is potentially linked to oxidative stress in PE, since its level correlates with the concentration of the powerful antioxidant CoQ(10).	coq	182-185	interleukin 18	Homo sapiens	49-54
19885017-7	2009	Catalase activity decreased significantly in both the control and CoQ(10) groups treated with NDEA, again with the effect being less in the CoQ(10) group.	coq	66-69	catalase	Mus musculus	0-8
19885017-7	2009	Catalase activity decreased significantly in both the control and CoQ(10) groups treated with NDEA, again with the effect being less in the CoQ(10) group.	coq	140-143	catalase	Mus musculus	0-8
18952046-5	2009	mGPDH-dependent ROS production was localized to the dehydrogenase+CoQ and complex III, the latter being the highest in all mitochondria but BAT.	coq	66-69	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	0-5
19526856-7	2009	We suggest that UCP3 is not involved in the increase of the passive H-conductance through the inner mitochondrial membrane in the aging heart, and that CoQ as a factor of respiratory chain could be an important endogenous regulator of the uncoupling proteins, in particular UCP3, in the heart.	coq	152-155	uncoupling protein 3	Rattus norvegicus	274-278
19526856-3	2009	Under activation of endogenous synthesis of CoQ it was observed almost complete restoration of UCP3 expression in old rat heart and a decrease in the sensitivity of the MPTP opening to Ca2+.	coq	44-47	uncoupling protein 3	Rattus norvegicus	95-99
19526856-6	2009	The results obtained allowed to conclude that the CoQ-dependent restoration of the UCP3 levels in old rat heart and antioxidant/cardioprotective effects of CoQ related to the MPTP opening inhibition can reduce the oxidative stress and thus prevent the manifestation of mitochondrial dysfunction in aging heart.	coq	50-53	uncoupling protein 3	Rattus norvegicus	83-87
19020091-1	2008	We have restored the CoQ oxidative capacity of mouse mtDNA-less cells (rho degrees cells) by transforming them with the alternative oxidase Aox of Emericella nidulans.	coq	21-24	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	140-143
19020091-3	2008	CoQ oxidation by AOX reduces the dependence of rho degrees cells on pyruvate and uridine.	coq	0-3	acyl-CoA oxidase 1	Homo sapiens	17-20
19049556-6	2008	RESULTS: At baseline serum CoQ(10) and vitamin E levels were significantly decreased in the FRDA patients (P < 0.001).	coq	27-30	frataxin	Homo sapiens	92-96
19049556-11	2008	CONCLUSIONS: A high proportion of FRDA patients have a decreased serum CoQ(10) level which was the best predictor of a positive clinical response to CoQ(10)/vitamin E therapy.	coq	71-74	frataxin	Homo sapiens	34-38
19049556-11	2008	CONCLUSIONS: A high proportion of FRDA patients have a decreased serum CoQ(10) level which was the best predictor of a positive clinical response to CoQ(10)/vitamin E therapy.	coq	149-152	frataxin	Homo sapiens	34-38
18319074-7	2008	ADCK3 is a mitochondrial protein homologous to the yeast COQ8 and the bacterial UbiB proteins, which are required for CoQ biosynthesis.	coq	118-121	coenzyme Q8A	Homo sapiens	0-5
18319074-7	2008	ADCK3 is a mitochondrial protein homologous to the yeast COQ8 and the bacterial UbiB proteins, which are required for CoQ biosynthesis.	coq	118-121	protein kinase COQ8	Saccharomyces cerevisiae S288C	57-61
19083397-11	2008	In conclusion, our results indicate that CoQ(10) and alpha-tocopherol decrease glycated HbA1c and pancreatic lipid peroxidation.	coq	41-44	hemoglobin alpha, adult chain 1	Rattus norvegicus	88-92
17488278-3	2007	In this study, we show the differential expression of CoQ in different muscles is triggered by calcitonin gene-related peptide (CGRP), a known motor neuron-derived factor.	coq	54-57	calcitonin related polypeptide alpha	Homo sapiens	95-126
17488278-3	2007	In this study, we show the differential expression of CoQ in different muscles is triggered by calcitonin gene-related peptide (CGRP), a known motor neuron-derived factor.	coq	54-57	calcitonin related polypeptide alpha	Homo sapiens	128-132
12372563-6	2002	Of these compounds, only CoQ(10) or NAC was able to restore the numbers of mature myelin basic protein-positive cells and the ability of the oligodendrocytes to form membrane sheets.	coq	25-28	myelin basic protein	Homo sapiens	82-102
16830230-7	2006	Both of these events, as well as the release of cytochrome c from the mitochondria, were blocked by a 24 h pre-treatment with CoQ(10).	coq	126-129	cytochrome c, somatic	Homo sapiens	48-60
16830230-9	2006	Recombinant Bax protein alone caused the ROS generation and release of cytochrome c from isolated mitochondria and, again, CoQ(10) inhibited these Bax-induced mitochondrial dysfunctions.	coq	123-126	BCL2 associated X, apoptosis regulator	Homo sapiens	12-15
16830230-9	2006	Recombinant Bax protein alone caused the ROS generation and release of cytochrome c from isolated mitochondria and, again, CoQ(10) inhibited these Bax-induced mitochondrial dysfunctions.	coq	123-126	BCL2 associated X, apoptosis regulator	Homo sapiens	147-150
15905035-4	2005	In the present study, we examined the effect of CoQ and its isoprenoid side chain length variants on the growth of cells having different p53 statuses.	coq	48-51	tumor protein p53	Homo sapiens	138-141
15905035-10	2005	Overall, these results suggested that short tail CoQ induces ROS generation and further p53-dependent apoptosis.	coq	49-52	tumor protein p53	Homo sapiens	88-91
16048353-3	2005	HMG-CoA reductase is also the first committed rate-limiting step for the synthesis of a range of other compounds including steroid hormones and ubidecarenone (ubiquinone), otherwise known as coenzyme Q(10) (CoQ(10)).	coq	207-210	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-17
15240412-3	2004	Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q(10) (CoQ(10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP(+) is demonstrated.	coq	85-88	hexokinase 1	Homo sapiens	191-201
12372563-7	2002	If TNF-alpha treatment causes oxidative damage by compromising oxidative metabolism in oligodendrocytes, increasing products of lipid peroxidation and/or generating radical oxygen species that can interfere with maturation signals, CoQ(10) and NAC may protect oligodendrocytes by reversing one or more of those destructive processes during terminal maturation.	coq	232-235	tumor necrosis factor	Homo sapiens	3-12
12653178-12	2002	We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents.	coq	45-48	tumor necrosis factor	Homo sapiens	62-71
12653178-12	2002	We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents.	coq	45-48	interleukin 6	Homo sapiens	76-80
35500860-10	2022	Although our data provide further evidence of a link between fragile X mental retardation protein (FMRP) and CoQ biosynthesis, the results highlight the importance of CoQ in developing tissues and suggest tissue-specific differences from CoQ deficiency.	coq	109-112	fragile X messenger ribonucleoprotein 1	Mus musculus	99-103
11725867-2	2001	I would like to suggest that in brown fat of control mice, UCP1 is present in an amount higher than UCP2 and 3 and, therefore, is able to cause (a) some fatty acid-mediated decrease in proton motive force in resting state and, hence, (b) oxidation of CoQH2 to CoQ which is shown by Klingenberg and coworkers to be cofactor for UCPs.	coq	251-254	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	59-63
9266535-3	1997	The Km of succinate- coenzyme Q reductase for CoQ1 is reversibly lowered in CoQ-depleted mitochondria; while in contrast the Km for NADH-coenzyme Q reductase is reversibly increased by CoQ extraction.	coq	46-49	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	132-157
9266535-3	1997	The Km of succinate- coenzyme Q reductase for CoQ1 is reversibly lowered in CoQ-depleted mitochondria; while in contrast the Km for NADH-coenzyme Q reductase is reversibly increased by CoQ extraction.	coq	76-79	decaprenyl diphosphate synthase subunit 1	Homo sapiens	46-50
9266535-3	1997	The Km of succinate- coenzyme Q reductase for CoQ1 is reversibly lowered in CoQ-depleted mitochondria; while in contrast the Km for NADH-coenzyme Q reductase is reversibly increased by CoQ extraction.	coq	76-79	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	132-157
1668635-3	1991	The flux control coefficients of carnitine palmitoyltransferase II, ETF:CoQ oxidoreductase and beta-hydroxybutyrate dehydrogenase were determined from elasticity coefficients obtained by measuring the flux dependencies of acyl-CoA and acetyl-CoA+CoASH concentrations, the electron transfer flavoprotein redox state, the CoQ redox state and the NAD redox state.	coq	72-75	electron transfer flavoprotein subunit alpha	Rattus norvegicus	68-71
34808207-2	2022	Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in the mitochondrial H2S oxidation pathway, using CoQ as an electron acceptor, and connects to the electron transport chain at the level of complex III.	coq	113-116	crystallin, zeta	Mus musculus	8-30
34680574-5	2021	This led to a decrease in demethoxyubiquinone, which is an intermediate metabolite of CoQ biosynthesis that is abnormally accumulated in Coq9R239X mice.	coq	86-89	coenzyme Q9	Mus musculus	137-141
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	atlastin GTPase 1	Homo sapiens	27-59
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	atlastin GTPase 1	Homo sapiens	61-65
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	apoptosis inducing factor mitochondria associated 2	Homo sapiens	81-86
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	NFE2 like bZIP transcription factor 2	Homo sapiens	119-162
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	atlastin GTPase 1	Homo sapiens	207-211
35459868-3	2022	In this study, we identify ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) as a transcriptional target of nuclear factor erythroid 2-related factor 2 (NRF2) and reveal that the ubiquinone (CoQ)-FSP1 axis mediates ferroptosis- and radiation- resistance in KEAP1 deficient lung cancer cells.	coq	202-205	kelch like ECH associated protein 1	Homo sapiens	268-273
35205819-1	2022	BACKGROUND: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism.	coq	144-147	aarF domain containing kinase 2	Homo sapiens	12-17