PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19652390-2 2009 Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. beta-Lactams 35-46 solute carrier family 15 member 1 Homo sapiens 115-120 19652390-2 2009 Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. Cephalexin 58-68 solute carrier family 15 member 1 Homo sapiens 115-120 19652390-2 2009 Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. Cephalexin 70-82 solute carrier family 15 member 1 Homo sapiens 115-120 19652390-3 2009 Indeed, after the incubation with L-cephalexin, the intact form of L-cephalexin has not been identified inside vesicles/proteoliposomes prepared from brush border membrane of intestinal epithelial cells or cultured cell lines exogenously transfected with PEPT1 gene. Cephalexin 67-79 solute carrier family 15 member 1 Homo sapiens 255-260 19652390-4 2009 Thus, it appears that L-cephalexin is rapidly metabolized by PEPT1 or PEPT1-associated proteins. Cephalexin 22-34 solute carrier family 15 member 1 Homo sapiens 61-66 19652390-4 2009 Thus, it appears that L-cephalexin is rapidly metabolized by PEPT1 or PEPT1-associated proteins. Cephalexin 22-34 solute carrier family 15 member 1 Homo sapiens 70-75 19652390-5 2009 Here, we attempted to verify whether L-cephalexin is transported by PEPT1 and whether it is hydrolyzed by PEPT1 itself, by using budded baculovirus expressing PEPT1 protein. Cephalexin 37-49 solute carrier family 15 member 1 Homo sapiens 68-73 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 33-38 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 148-153 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 116-128 solute carrier family 15 member 1 Homo sapiens 33-38 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 116-128 solute carrier family 15 member 1 Homo sapiens 148-153 19652390-8 2009 Thus, L-cephalexin is transported by PEPT1 itself. Cephalexin 6-18 solute carrier family 15 member 1 Homo sapiens 37-42 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. l- and d-cephalexin 27-46 solute carrier family 15 member 1 Homo sapiens 50-55 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. l- and d-cephalexin 27-46 solute carrier family 15 member 1 Homo sapiens 209-214 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. Cephalexin 192-204 solute carrier family 15 member 1 Homo sapiens 50-55 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. Cephalexin 192-204 solute carrier family 15 member 1 Homo sapiens 209-214 19652390-11 2009 We conclude that L-cephalexin is transported by PEPT1 with high affinity, but is not metabolized by PEPT1 itself. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 48-53 13052669-0 1953 Does a large intake of potassium modify the metabolic effects of ACTH in man? Potassium 23-32 proopiomelanocortin Homo sapiens 65-69 13055983-0 1953 Epinephrine and insulin effect on potassium mobilization; relationship of lipid and carbohydrate metabolism. Potassium 34-43 insulin Homo sapiens 16-23 13031658-2 1953 Replacement of potassium in erythrocytes during cholinesterase activity. Potassium 15-24 butyrylcholinesterase Homo sapiens 48-62 13124845-0 1953 [Effect of potassium on secretion of ACTH; role of corticosteroids]. Potassium 11-20 proopiomelanocortin Homo sapiens 37-41 13148681-0 1953 [Effect of potassium on ACTH secretion; role of corticosteroids]. Potassium 11-20 proopiomelanocortin Homo sapiens 24-28 13016806-0 1952 Sodium, potassium and chloride retention produced by growth hormone in the absence of the adrenals. Potassium 8-17 growth hormone 1 Homo sapiens 53-67 14927720-0 1952 The influence of ACTH on the sodium and potassium concentration of human mixed saliva. Potassium 40-49 proopiomelanocortin Homo sapiens 17-21 14958479-0 1952 The electrocardiographic and plasma potassium changes after adrenalin and insulin injections. Potassium 36-45 insulin Homo sapiens 74-81 13208668-0 1952 [The role of magnesium and potassium in the reaction of fructokinase]. Potassium 27-36 ketohexokinase Homo sapiens 56-68 14917842-0 1952 The effect of ACTH and cortisone on the sodium and potassium levels of human saliva. Potassium 51-60 proopiomelanocortin Homo sapiens 14-18 14920503-0 1952 Reduction of urinary sodium and potassium produced by hypophyseal growth hormone in normal female rats. Potassium 32-41 gonadotropin releasing hormone receptor Rattus norvegicus 66-80 14914876-0 1952 Effect of cholinesterase and choline acetylase inhibitors on the potassium concentration gradient and potassium exchange of human erythrocytes. Potassium 65-74 butyrylcholinesterase Homo sapiens 10-24 14914876-0 1952 Effect of cholinesterase and choline acetylase inhibitors on the potassium concentration gradient and potassium exchange of human erythrocytes. Potassium 65-74 choline O-acetyltransferase Homo sapiens 29-46 14914876-0 1952 Effect of cholinesterase and choline acetylase inhibitors on the potassium concentration gradient and potassium exchange of human erythrocytes. Potassium 102-111 butyrylcholinesterase Homo sapiens 10-24 14914876-0 1952 Effect of cholinesterase and choline acetylase inhibitors on the potassium concentration gradient and potassium exchange of human erythrocytes. Potassium 102-111 choline O-acetyltransferase Homo sapiens 29-46 14911014-0 1952 Body potassium loss during therapy with ACTH and cortisone. Potassium 5-14 proopiomelanocortin Homo sapiens 40-44 14906298-0 1951 The effect of epinephrine and insulin on the plasma potassium level. Potassium 52-61 insulin Homo sapiens 30-37 14857892-0 1951 The influence of glucose and insulin upon the potassium concentration of serum and cerebrospinal fluid. Potassium 46-55 insulin Homo sapiens 29-36 14864646-0 1951 Reduction of urinary sodium and potassium of diabetic rats produced by hypophyseal growth hormone. Potassium 32-41 gonadotropin releasing hormone receptor Rattus norvegicus 83-97 14866879-0 1951 Potassium, sodium, water content and adenosinetriphosphatase activity of vas deferens from normal and castrated rats. Potassium 0-9 arginine vasopressin Rattus norvegicus 73-76 14795066-0 1950 The effects of sodium and potassium on the metabolic and physiologic responses to ACTH. Potassium 26-35 proopiomelanocortin Homo sapiens 82-86 14791434-0 1950 The influence of carbohydrates and insulin on the potassium content of leucocytes and muscle. Potassium 50-59 insulin Homo sapiens 35-42 19873117-14 1939 As in previous experiments, the entering ammonia displaced a practically equivalent amount of potassium from the sap and the sodium concentration remained fairly constant. Potassium 94-103 SH2 domain containing 1A Homo sapiens 113-116 19872878-5 1935 The treatment with distilled water which removes the potassium effect from the outer protoplasmic surface does not seem to affect the inner protoplasmic surface in the same way since the latter retains the outwardly directed potential which is apparently due to the potassium in the sap. Potassium 266-275 SH2 domain containing 1A Homo sapiens 283-286 19872836-4 1934 Potassium passes from the external solution through the non-aqueous layer into the artificial sap and there reacts with CO(2) to form KHCO(3): its rate of entrance depends on the supply of CO(2). Potassium 0-9 SH2 domain containing 1A Homo sapiens 94-97 19872836-6 1934 By regulating the supply of CO(2) and the osmotic pressure we are able to keep the volume and composition of the artificial sap approximately constant while maintaining a higher concentration of potassium than in the external solution. Potassium 195-204 SH2 domain containing 1A Homo sapiens 124-127 19872792-21 1934 Since CO(2) and HCO(3) (-) diffuse into A and combine with KG and NaG the inward movement of potassium and sodium falls off in proportion as the concentration of KG and NaG is lessened. Potassium 93-102 NBAS subunit of NRZ tethering complex Homo sapiens 59-69 19872792-21 1934 Since CO(2) and HCO(3) (-) diffuse into A and combine with KG and NaG the inward movement of potassium and sodium falls off in proportion as the concentration of KG and NaG is lessened. Potassium 93-102 NBAS subunit of NRZ tethering complex Homo sapiens 66-69 19872676-9 1932 Potassium penetrates by combining with an acid HX in the non-aqueous layer to form KX which in turn reacts with an acid HA in the sap to form KA. Potassium 0-9 SH2 domain containing 1A Homo sapiens 130-133 19872676-12 1932 The internal composition depends on permeability, e.g., sodium penetrates less rapidly than potassium and in consequence potassium predominates over sodium in the "artificial sap." Potassium 121-130 SH2 domain containing 1A Homo sapiens 175-178 19872627-7 1931 (21) have shown that potassium and phosphorus of the blood are decreased and Luck, Morrison, and Wilbur (22) indicate a reduction in the amino acids of the blood in insulin treatment. Potassium 21-30 insulin Bos taurus 165-172 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 41-43 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 44-49 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 41-43 polybromo 1 Homo sapiens 50-53 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 41-43 polybromo 1 Homo sapiens 165-168 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 80-82 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 83-88 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 80-82 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 83-88 33992895-7 2021 The values of the binding constants were KS(PTP1B-PB1) = 4.06 x 102 L mol-1 and KS(PTP1B-PB2) = 2.53 x 102 L mol-1, indicating that the binding affinity of PTP1B to PB1 was higher than that for PB2. Potassium 80-82 polybromo 1 Homo sapiens 165-168 33978701-8 2021 Remarkably, whole-cell patch-clamp recording demonstrated that risperidone acutely inhibited the activity of hypothalamic Mc4r neurons via the opening of a postsynaptic potassium conductance. Potassium 169-178 melanocortin 4 receptor Mus musculus 122-126 33667541-1 2021 It is well-established that extracellular potassium (Ko+) accumulation reduces muscle fiber excitability, however the effects of Ko+ on the excitation-contraction coupling (ECC) pathway are less understood. Potassium 42-51 keratin 8 Homo sapiens 53-55 33861146-11 2021 Potassium levels were also associated with insulin-mediated reductions in AP (r=0.52, P=0.002). Potassium 0-9 insulin Homo sapiens 43-50 33866617-3 2021 Research in male rodents has shown that activation of PAR2 can produce peripheral vasodilation, stimulate renal sodium chloride reabsorption, and inhibit renal potassium secretion. Potassium 160-169 F2R like trypsin receptor 1 Rattus norvegicus 54-58 33866617-10 2021 Research in male rodents has shown that activation of PAR2 can produce peripheral vasodilation, stimulate renal sodium chloride reabsorption, and inhibit renal potassium secretion. Potassium 160-169 F2R like trypsin receptor 1 Rattus norvegicus 54-58 33050826-2 2021 Functional hyperemia depends on capillary endothelial cell inward rectifier potassium channels (Kir2.1) responding to potassium (K+) released during neuronal activity to produce a regenerative, hyperpolarizing electrical signal that propagates from capillaries to dilate upstream penetrating arterioles. Potassium 76-85 potassium inwardly-rectifying channel, subfamily J, member 2 Mus musculus 96-102 33968186-5 2021 The present review aimed to determine whether activated CaMKII induces early afterdepolarizations and delayed afterdepolarizations that result in VA by regulating sodium, potassium and calcium ions. Potassium 171-180 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-62 34047430-6 2021 We characterized whole-cell potassium and sodium currents, both involved in action potential (AP) shaping and propagation and determined NO-mediated changes in excitabilities and AP waveforms. Potassium 28-37 LIM homeobox protein 2 Mus musculus 94-96 34047430-7 2021 Our data describe a novel signaling by which NO, in a cGMP-independent manner, suppresses voltage-gated Kv2 potassium and voltage-gated sodium channel activities, thereby widening AP waveforms and reducing depolarization-induced AP firing rates. Potassium 108-117 LIM homeobox protein 2 Mus musculus 180-182 34047430-7 2021 Our data describe a novel signaling by which NO, in a cGMP-independent manner, suppresses voltage-gated Kv2 potassium and voltage-gated sodium channel activities, thereby widening AP waveforms and reducing depolarization-induced AP firing rates. Potassium 108-117 LIM homeobox protein 2 Mus musculus 229-231 34052311-7 2021 In potassium-free buffer, LDL(-)-induced IL-1beta reached a level similar to that induced by cotreatment with LDL(-) and PA-BSA. Potassium 3-12 interleukin 1 alpha Homo sapiens 41-49 34038119-2 2021 Our first disclosed clinical ROMK compound, 2 (MK-7145), demonstrated robust diuresis, natriuresis, and blood pressure lowering in preclinical models, with reduced urinary potassium excretion compared to the standard of care diuretics. Potassium 172-181 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 29-33 33909591-7 2021 The deletion was 1.8 Mb upstream of a KS candidate gene locus (PALM2AKAP2), but did not suppress its expression. Potassium 38-40 PALM2 and AKAP2 fusion Homo sapiens 63-73 33280043-0 2021 Title: Effect of increased potassium intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study. Potassium 27-36 renin Homo sapiens 51-56 34029145-6 2021 Renal clearance experiments showed that HK-intake decreased while LK intake increased hydrochlorothiazide (HCTZ)-induced renal Na+ excretion only in the control mice but this effect was absent in Ks-Nedd4-2 KO mice. Potassium 196-198 neural precursor cell expressed, developmentally down-regulated 4 Mus musculus 199-204 34029145-8 2021 Furthermore, the expression of all three subunits of epithelia-Na+-channel (ENaC) in the Ks-Nedd4-2 KO mice on HK was higher than in the control mice. Potassium 89-91 sodium channel, nonvoltage-gated 1 alpha Mus musculus 53-74 34029145-8 2021 Furthermore, the expression of all three subunits of epithelia-Na+-channel (ENaC) in the Ks-Nedd4-2 KO mice on HK was higher than in the control mice. Potassium 89-91 sodium channel, nonvoltage-gated 1 alpha Mus musculus 76-80 34013341-4 2021 PURPOSE: To provide evidence of serum potassium changes in individuals taking angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) concomitantly with spironolactone compared to ACEI/ARB therapy alone. Potassium 38-47 angiotensin I converting enzyme Homo sapiens 78-107 34029145-8 2021 Furthermore, the expression of all three subunits of epithelia-Na+-channel (ENaC) in the Ks-Nedd4-2 KO mice on HK was higher than in the control mice. Potassium 89-91 neural precursor cell expressed, developmentally down-regulated 4 Mus musculus 92-97 33993515-3 2021 This meta-analysis was performed to determine the impact of alternative insulin dosing on hypoglycemia and potassium reduction in patients with hyperkalemia. Potassium 107-116 insulin Homo sapiens 72-79 33993515-0 2021 Reduced Alternative Insulin Dosing in Hyperkalemia: a Meta-Analysis of Effects on Hypoglycemia and Potassium Reduction. Potassium 99-108 insulin Homo sapiens 20-27 33993515-11 2021 CONCLUSIONS: Alternative insulin dosing strategies for hyperkalemia management resulted in less hypoglycemia and severe hypoglycemia without compromising potassium reduction compared to standard dose. Potassium 154-163 insulin Homo sapiens 25-32 33990773-6 2021 NRG1 and ErbB4 suppressed potassium currents of VTA DA neurons and increased their firing activity. Potassium 26-35 neuregulin 1 Mus musculus 0-4 33990773-6 2021 NRG1 and ErbB4 suppressed potassium currents of VTA DA neurons and increased their firing activity. Potassium 26-35 erb-b2 receptor tyrosine kinase 4 Mus musculus 9-14 34017331-8 2021 Moreover, this process of SEO+ATP-induced IL-1beta secretion was dependent on potassium (K+) efflux. Potassium 78-87 interleukin 1 alpha Mus musculus 42-50 34054566-2 2021 The renal outer medullary potassium (ROMK) channel accounts for the major K+ secretory route in collecting ducts during basal conditions. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 37-41 33978965-6 2021 The comparison of the molecular structures of two closely related potassium silolides provided an example for different coordination of the potassium cation to the silolyl anion (eta 1 vs. eta 5 coordination) that triggers the switch between delocalized and localized states. Potassium 66-75 secreted phosphoprotein 1 Homo sapiens 179-184 33960280-4 2021 Comprehensive ophthalmic examinations, however, guided the diagnosis of CDSRR from a novel mutation in potassium voltage-gated channel modifier subfamily V member 2 (KCNV2) gene.Materials and methods: Comprehensive ophthalmic examinations were evaluated for two patients whose parents are first cousins. Potassium 103-112 potassium voltage-gated channel modifier subfamily V member 2 Homo sapiens 166-171 34025388-9 2021 Age-related CAPD subjects had a lower intake of potassium, vitamin C, and a higher fat intake. Potassium 48-57 renin binding protein Homo sapiens 0-3 33870711-7 2021 In contrast, the hemodynamic responses (blood pressure, total peripheral resistance, cardiac output, and renal artery blood flow) to AngII were similar after potassium and placebo. Potassium 158-167 angiotensinogen Homo sapiens 133-138 33870711-0 2021 Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study. Potassium 20-29 angiotensinogen Homo sapiens 89-103 33870711-8 2021 Conclusions Increased potassium intake potentiates AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men. Potassium 22-31 angiotensinogen Homo sapiens 51-56 33870711-6 2021 The study showed that higher potassium intake increased plasma potassium (mean+-SD, 4.3+-0.2 versus 4.0+-0.2 mmol/L; P=0.0002) and aldosterone (median [interquartile range], 440 [336-521] versus 237 [173-386] pmol/L; P<0.0001), and based on a linear mixed model for repeated measurements, increased potassium intake potentiated AngII-stimulated aldosterone secretion (P=0.0020). Potassium 29-38 angiotensinogen Homo sapiens 328-333 33439774-5 2021 We therefore investigated whether potassium regulates WNK activity independent of chloride. Potassium 34-43 Wnk kinase Drosophila melanogaster 54-57 33934480-12 2021 CONCLUSION: pH-adjusted potassium (pHK ) shall be used as a marker for hypokalemia and to initiate potassium replacement instead of measure serum potassium in DKA. Potassium 24-33 phosphorylase kinase regulatory subunit alpha 2 Homo sapiens 35-38 33934480-12 2021 CONCLUSION: pH-adjusted potassium (pHK ) shall be used as a marker for hypokalemia and to initiate potassium replacement instead of measure serum potassium in DKA. Potassium 99-108 phosphorylase kinase regulatory subunit alpha 2 Homo sapiens 35-38 33934480-12 2021 CONCLUSION: pH-adjusted potassium (pHK ) shall be used as a marker for hypokalemia and to initiate potassium replacement instead of measure serum potassium in DKA. Potassium 99-108 phosphorylase kinase regulatory subunit alpha 2 Homo sapiens 35-38 33682442-3 2021 It has recently been shown that a less severe form of the Familial Hyperkalemic Hypertension featuring only hyperkalemia is caused by missense mutations in the WNK1 acidic domain that preferentially affect CUL3-KLHL3 E3-induced degradation of KS-WNK1, rather than that of the full-length WNK1 (L-WNK1). Potassium 243-245 WNK lysine deficient protein kinase 1 Mus musculus 160-164 33682442-3 2021 It has recently been shown that a less severe form of the Familial Hyperkalemic Hypertension featuring only hyperkalemia is caused by missense mutations in the WNK1 acidic domain that preferentially affect CUL3-KLHL3 E3-induced degradation of KS-WNK1, rather than that of the full-length WNK1 (L-WNK1). Potassium 243-245 cullin 3 Mus musculus 206-210 33439774-6 2021 We found decreased activity of Drosophila WNK and mammalian WNK3 and WNK4 in fly Malpighian (renal) tubules bathed in high extracellular potassium, even when intracellular chloride was kept constant at either ~13 mM or 26 mM. Potassium 137-146 Wnk kinase Drosophila melanogaster 42-45 33439774-6 2021 We found decreased activity of Drosophila WNK and mammalian WNK3 and WNK4 in fly Malpighian (renal) tubules bathed in high extracellular potassium, even when intracellular chloride was kept constant at either ~13 mM or 26 mM. Potassium 137-146 WNK lysine deficient protein kinase 3 Homo sapiens 60-64 33439774-6 2021 We found decreased activity of Drosophila WNK and mammalian WNK3 and WNK4 in fly Malpighian (renal) tubules bathed in high extracellular potassium, even when intracellular chloride was kept constant at either ~13 mM or 26 mM. Potassium 137-146 WNK lysine deficient protein kinase 4 Homo sapiens 69-73 33439774-7 2021 High extracellular potassium also inhibited chloride-insensitive mutants of WNK3 and WNK4. Potassium 19-28 WNK lysine deficient protein kinase 3 Homo sapiens 76-80 33749322-11 2021 Together these data indicate that AQP2 regulation is disrupted by a small decrease in PK and the response is influenced by sexual dimorphism in potassium handling. Potassium 144-153 aquaporin 2 Mus musculus 34-38 33439774-7 2021 High extracellular potassium also inhibited chloride-insensitive mutants of WNK3 and WNK4. Potassium 19-28 WNK lysine deficient protein kinase 4 Homo sapiens 85-89 33439774-9 2021 The Na+/K+-ATPase inhibitor, ouabain, which is expected to lower intracellular potassium, increased tubule Drosophila WNK activity. Potassium 79-88 Wnk kinase Drosophila melanogaster 118-121 33439774-10 2021 In vitro, potassium increased the melting temperature of Drosophila WNK, WNK1 and WNK3 kinase domains, indicating ion binding to the kinase. Potassium 10-19 Wnk kinase Drosophila melanogaster 68-71 33439774-10 2021 In vitro, potassium increased the melting temperature of Drosophila WNK, WNK1 and WNK3 kinase domains, indicating ion binding to the kinase. Potassium 10-19 WNK lysine deficient protein kinase 3 Homo sapiens 82-86 33439774-11 2021 Potassium inhibited in vitro autophosphorylation of Drosophila WNK and WNK3, and also inhibited WNK3 and WNK4 phosphorylation of their substrate, SPAK (Ste20-related proline/alanine-rich kinase). Potassium 0-9 Wnk kinase Drosophila melanogaster 63-66 33439774-11 2021 Potassium inhibited in vitro autophosphorylation of Drosophila WNK and WNK3, and also inhibited WNK3 and WNK4 phosphorylation of their substrate, SPAK (Ste20-related proline/alanine-rich kinase). Potassium 0-9 WNK lysine deficient protein kinase 3 Homo sapiens 71-75 33439774-11 2021 Potassium inhibited in vitro autophosphorylation of Drosophila WNK and WNK3, and also inhibited WNK3 and WNK4 phosphorylation of their substrate, SPAK (Ste20-related proline/alanine-rich kinase). Potassium 0-9 WNK lysine deficient protein kinase 3 Homo sapiens 96-100 33439774-11 2021 Potassium inhibited in vitro autophosphorylation of Drosophila WNK and WNK3, and also inhibited WNK3 and WNK4 phosphorylation of their substrate, SPAK (Ste20-related proline/alanine-rich kinase). Potassium 0-9 WNK lysine deficient protein kinase 4 Homo sapiens 105-109 33439774-11 2021 Potassium inhibited in vitro autophosphorylation of Drosophila WNK and WNK3, and also inhibited WNK3 and WNK4 phosphorylation of their substrate, SPAK (Ste20-related proline/alanine-rich kinase). Potassium 0-9 mushroom bodies tiny Drosophila melanogaster 152-157 33439774-12 2021 The greatest sensitivity of WNK4 to potassium occurred in the range of 80 to 180 mM, encompassing physiological intracellular potassium concentrations. Potassium 36-45 WNK lysine deficient protein kinase 4 Homo sapiens 28-32 33439774-12 2021 The greatest sensitivity of WNK4 to potassium occurred in the range of 80 to 180 mM, encompassing physiological intracellular potassium concentrations. Potassium 126-135 WNK lysine deficient protein kinase 4 Homo sapiens 28-32 33439774-13 2021 Together, these data indicate chloride-independent potassium inhibition of Drosophila and mammalian WNK kinases through direct effects of potassium ion on the kinase. Potassium 51-60 Wnk kinase Drosophila melanogaster 100-103 33439774-13 2021 Together, these data indicate chloride-independent potassium inhibition of Drosophila and mammalian WNK kinases through direct effects of potassium ion on the kinase. Potassium 138-147 Wnk kinase Drosophila melanogaster 100-103 33388987-1 2021 PURPOSE: To determine patients with abnormal sensation in the throat (AST) who would respond to potassium-competitive acid blocker (P-CAB) or serotonin noradrenaline reuptake inhibitor (SNRI) treatment. Potassium 96-105 neural proliferation, differentiation and control 1 Homo sapiens 134-137 33581123-4 2021 IL-4-stimulated eotaxin-3 secretion was measured by ELISA after treatment with omeprazole, SCH 28080 (potassium-competitive acid blocker), EGTA-AM (calcium chelator), 2-APB (inhibitor of endoplasmic reticulum calcium release), verapamil and diltiazem (L-type calcium channel inhibitors). Potassium 102-111 interleukin 4 Homo sapiens 0-4 33581123-4 2021 IL-4-stimulated eotaxin-3 secretion was measured by ELISA after treatment with omeprazole, SCH 28080 (potassium-competitive acid blocker), EGTA-AM (calcium chelator), 2-APB (inhibitor of endoplasmic reticulum calcium release), verapamil and diltiazem (L-type calcium channel inhibitors). Potassium 102-111 C-C motif chemokine ligand 26 Homo sapiens 16-25 33423833-8 2021 Redistribution of potassium ions from the bloodstream into the cells is based on intravenous insulin or nebulized beta2-agonists. Potassium 18-27 insulin Homo sapiens 93-100 33705345-4 2021 Supplementation of potassium inhibited the effect of aldosterone on the Rhcg. Potassium 19-28 Rhesus blood group-associated C glycoprotein Mus musculus 72-76 33705345-13 2021 These results suggest that aldosterone regulates the membrane expression of Rhcg through the mineralocorticoid receptor and PKC pathways, which is modulated by extracellular potassium level. Potassium 174-183 Rhesus blood group-associated C glycoprotein Mus musculus 76-80 33423833-8 2021 Redistribution of potassium ions from the bloodstream into the cells is based on intravenous insulin or nebulized beta2-agonists. Potassium 18-27 ATPase H+ transporting V0 subunit a2 Homo sapiens 114-119 33411244-6 2021 The non-edited Kv1.1 overexpression led to slight elevations in both fast- and non-inactivating current components of macroscopic potassium current. Potassium 130-139 potassium voltage-gated channel subfamily A member 1 Homo sapiens 15-20 33657579-0 2021 Effect of potassium on DNA methylation of aldosterone synthase gene. Potassium 10-19 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 42-62 33657579-1 2021 BACKGROUND: Aldosterone synthase gene, CYP11B2 is regulated by potassium and angiotensin II (Ang II). Potassium 63-72 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 12-32 33657579-1 2021 BACKGROUND: Aldosterone synthase gene, CYP11B2 is regulated by potassium and angiotensin II (Ang II). Potassium 63-72 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 39-46 33657579-3 2021 Similar to Ang II, small increases in extracellular potassium levels also increase CYP11B2 mRNA levels. Potassium 52-61 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 83-90 33657579-8 2021 Potassium stimulation caused DNA demethylation around cyclic AMP responsive element binding protein 1 (CREB1) and nuclear receptor subfamily 4 group A (NR4A) family-binding sites and a TSS; demethylation was accompanied by recruitment of CREB1 and NR4A1 and increased chromatin accessibility of the CYP11B2 promoter. Potassium 0-9 cAMP responsive element binding protein 1 Homo sapiens 54-101 33657579-8 2021 Potassium stimulation caused DNA demethylation around cyclic AMP responsive element binding protein 1 (CREB1) and nuclear receptor subfamily 4 group A (NR4A) family-binding sites and a TSS; demethylation was accompanied by recruitment of CREB1 and NR4A1 and increased chromatin accessibility of the CYP11B2 promoter. Potassium 0-9 cAMP responsive element binding protein 1 Homo sapiens 103-108 33657579-8 2021 Potassium stimulation caused DNA demethylation around cyclic AMP responsive element binding protein 1 (CREB1) and nuclear receptor subfamily 4 group A (NR4A) family-binding sites and a TSS; demethylation was accompanied by recruitment of CREB1 and NR4A1 and increased chromatin accessibility of the CYP11B2 promoter. Potassium 0-9 cAMP responsive element binding protein 1 Homo sapiens 238-243 33657579-8 2021 Potassium stimulation caused DNA demethylation around cyclic AMP responsive element binding protein 1 (CREB1) and nuclear receptor subfamily 4 group A (NR4A) family-binding sites and a TSS; demethylation was accompanied by recruitment of CREB1 and NR4A1 and increased chromatin accessibility of the CYP11B2 promoter. Potassium 0-9 nuclear receptor subfamily 4 group A member 1 Homo sapiens 248-253 33657579-8 2021 Potassium stimulation caused DNA demethylation around cyclic AMP responsive element binding protein 1 (CREB1) and nuclear receptor subfamily 4 group A (NR4A) family-binding sites and a TSS; demethylation was accompanied by recruitment of CREB1 and NR4A1 and increased chromatin accessibility of the CYP11B2 promoter. Potassium 0-9 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 299-306 33657579-10 2021 DNA demethylation at CpG1 (Ad1), CpG2 (Ad5) and CpG3 were detected within 2 to 4 days after potassium (16 mmol/l) stimulation. Potassium 92-101 amyloid beta precursor protein Homo sapiens 27-30 33657579-10 2021 DNA demethylation at CpG1 (Ad1), CpG2 (Ad5) and CpG3 were detected within 2 to 4 days after potassium (16 mmol/l) stimulation. Potassium 92-101 Alzheimer disease, familial, type 5 Homo sapiens 39-42 33657579-15 2021 CONCLUSION: : Potassium induced reversibly DNA demethylation, which switches the phenotype of CYP11B2 expression from an inactive to an active state. Potassium 14-23 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 94-101 33336302-3 2021 Both noise-induced and hereditary progressive hearing have been linked to decreased cell surface expression and impaired conductance of the potassium ion channel KV7.4 (KCNQ4) in outer hair cells, inspiring future therapies to maintain or prevent the decline of potassium ion channel surface expression to reduce ARHL. Potassium 140-149 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 162-167 33336302-3 2021 Both noise-induced and hereditary progressive hearing have been linked to decreased cell surface expression and impaired conductance of the potassium ion channel KV7.4 (KCNQ4) in outer hair cells, inspiring future therapies to maintain or prevent the decline of potassium ion channel surface expression to reduce ARHL. Potassium 140-149 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 169-174 33004259-3 2021 Recent work revealed that HBL binds to the mammalian surface receptors LITAF and CDIP1 and that both HBL and NHE induce potassium efflux and activate the NLRP3 inflammasome, leading to pyroptosis. Potassium 120-129 NLR family pyrin domain containing 3 Homo sapiens 154-159 33925539-3 2021 The aldosterone synthase gene CYP11B2 is regulated by angiotensin II and potassium. Potassium 73-82 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 4-24 33925539-3 2021 The aldosterone synthase gene CYP11B2 is regulated by angiotensin II and potassium. Potassium 73-82 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 30-37 33904208-2 2021 For an efficient synthesis, potassium hexafluorophosphate (KPF6 ) is employed as a cation template; PEG6DA as well as PEG6DMA recognizes the potassium cation with the hexa(ethylene glycol) spacer to dynamically form a pseudo-cyclic divinyl monomer. Potassium 28-37 hexosaminidase subunit alpha Homo sapiens 38-42 33904208-3 2021 Those monomers interacting with the potassium cations are efficiently polymerized with RAFT agents and radical initiators into cyclopolymers comprising 24-membered hexa(ethylene glycol) rings. Potassium 36-45 hexosaminidase subunit alpha Homo sapiens 164-168 33899306-0 2021 Effects of SGLT2 inhibition with Empagliflozin on Potassium Handling in Patients with Acute Heart Failure. Potassium 50-59 solute carrier family 5 member 2 Homo sapiens 11-16 33899737-4 2021 We demonstrated that the essential factor controlling the diversity of the discharge pattern of embryonic V1R is the ratio of a persistent sodium conductance to a delayed rectifier potassium conductance. Potassium 181-190 vomeronasal 1 receptor 51 Mus musculus 106-109 33718825-5 2021 Using genetic and pharmacological inhibition, we show that the induction of mature IL-1beta is through a non-classical pathway dependent upon caspase-1, caspase-8, the NLRP3 inflammasome, potassium efflux, and autophagy while being independent of TRIF (TICAM1), vitamin D3, and pyroptosis. Potassium 188-197 interleukin 1 alpha Homo sapiens 83-91 33830722-0 2021 SnS2 Nanosheets Anchored on Nitrogen and Sulfur Co-Doped MXene Sheets for High-Performance Potassium-Ion Batteries. Potassium 91-100 sodium voltage-gated channel alpha subunit 11 Homo sapiens 0-4 33861365-5 2021 For patients with hyperkalemia during surgery, the odds ratios [ORs] of failure to decrease potassium (K+) after insulin treatment were higher in patients with eGFR < 30 mL/min/1.73 m2 (adjusted OR 3.24; 95% confidence interval 1.38-7.64; P = 0.007) than in patients with eGFR >= 60 mL/min/1.73 m2. Potassium 92-101 insulin Homo sapiens 113-120 33848364-4 2021 Until recently, the pathophysiology of hereditary xerocytosis was mainly believed to be based on the "PIEZO1-Gardos channel axis" in erythrocytes, according to which PIEZO1-activating mutations induce a calcium influx that secondarily activates the Gardos channel, leading to potassium and water efflux and subsequently to red blood cell dehydration. Potassium 276-285 piezo type mechanosensitive ion channel component 1 Homo sapiens 102-108 33848364-4 2021 Until recently, the pathophysiology of hereditary xerocytosis was mainly believed to be based on the "PIEZO1-Gardos channel axis" in erythrocytes, according to which PIEZO1-activating mutations induce a calcium influx that secondarily activates the Gardos channel, leading to potassium and water efflux and subsequently to red blood cell dehydration. Potassium 276-285 piezo type mechanosensitive ion channel component 1 Homo sapiens 166-172 33849496-8 2021 Restricted cubic spline analysis showed that potassium level was linearly and positively associated with long-term cancer mortality; HR per mmol/L 1.8, 95% CI 1.4-2.4. Potassium 45-54 immunoglobulin kappa variable 1-13 Homo sapiens 145-150 33829343-1 2021 The human ether-a-go-go related gene (hERG, KCNH2) encodes the pore-forming subunit of the potassium channel responsible for a fast component of the cardiac delayed rectifier potassium current (IKr). Potassium 91-100 ETS transcription factor ERG Homo sapiens 38-42 33829343-1 2021 The human ether-a-go-go related gene (hERG, KCNH2) encodes the pore-forming subunit of the potassium channel responsible for a fast component of the cardiac delayed rectifier potassium current (IKr). Potassium 91-100 potassium voltage-gated channel subfamily H member 2 Homo sapiens 44-49 33826405-1 2021 Inward rectifying potassium (Kir) channels play important roles in both excitable and non-excitable cells of various organ systems and could represent valuable new drug targets for cardiovascular, metabolic, immune and neurological diseases. Potassium 18-27 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 29-32 33688925-1 2021 The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium and potassium across the plasma membrane. Potassium 11-20 tachykinin precursor 1 Homo sapiens 29-32 33688925-1 2021 The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium and potassium across the plasma membrane. Potassium 89-98 tachykinin precursor 1 Homo sapiens 29-32 33953928-1 2021 The sodium potassium ion channel (NaK) is a nonselective ion channel that conducts both sodium and potassium across the cellular membrane. Potassium 11-20 TANK binding kinase 1 Homo sapiens 34-37 33741353-0 2021 A standardized glucose-insulin-potassium infusion protocol in surgical patients: use of real clinical data from a clinical data warehouse. Potassium 31-40 insulin Homo sapiens 23-30 33741353-1 2021 AIMS: We evaluated the clinical usefulness of a new unified glucose-insulin-potassium (GIK) regimen in a general surgical department. Potassium 76-85 insulin Homo sapiens 68-75 33214722-6 2021 Proper management of serum potassium is required to ensure safe clinical use of MR blockers, including awareness of at-risk patient groups, choosing appropriate dosages for therapy initiation and dosage titration, and monitoring of serum potassium during therapy. Potassium 27-36 nuclear receptor subfamily 3 group C member 2 Homo sapiens 80-82 33460257-0 2021 Potassium supplementation blunts the effects of high salt intake on serum retinol-binding protein 4 levels in healthy individuals. Potassium 0-9 retinol binding protein 4 Homo sapiens 74-99 33460257-1 2021 AIMS/INTRODUCTION: Excessive dietary salt or low potassium intakes are strongly correlated with insulin resistance (IR) and type 2 diabetes mellitus. Potassium 49-58 insulin Homo sapiens 96-103 33460257-4 2021 This study aimed to assess whether salt consumption and potassium supplementation influence serum RBP4 levels in healthy individuals. Potassium 56-65 retinol binding protein 4 Homo sapiens 98-102 33460257-10 2021 In addition, RBP4 levels presented positive (r = 0.528, P < 0.01) and negative (r = -0.506, P < 0.01) associations with 24-h urinary sodium- and potassium excretion levels. Potassium 145-154 retinol binding protein 4 Homo sapiens 13-17 33460257-11 2021 CONCLUSIONS: RBP4 synthesis is motivated by high salt intake and revoked by potassium supplementation. Potassium 76-85 retinol binding protein 4 Homo sapiens 13-17 33334222-5 2021 Results: Mutations in the KMT2D gene were identified in all of the 10 patients with KS. Potassium 84-86 lysine methyltransferase 2D Homo sapiens 26-31 33831355-5 2021 This structure, representing a key nucleotide-free activation intermediate, reveals how the potassium ion-binding K loop disrupts the nucleotide-binding site of Sar1. Potassium 92-101 Arf family GTPase SAR1 Saccharomyces cerevisiae S288C 161-165 33607471-1 2021 Bartter Syndrome (BS) is a group of rare inherited autosome-recessive disease, which can be caused by the gene mutations of sodium-potassium-chloride cotransporter gene (SLC12A1). Potassium 131-140 solute carrier family 12 member 1 Homo sapiens 170-177 33783609-2 2021 Therefore, this study aimed to investigate the role of potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1), a member of the lncRNA voltage-gated channel subfamily Q, in the development of osteoarthritis. Potassium 55-64 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 134-142 33870140-0 2021 Potassium ions promote hexokinase-II dependent glycolysis. Potassium 0-9 hexokinase 2 Homo sapiens 23-36 33750980-12 2021 The SD1 were negatively correlated to soil pH, hydrogen (H+), potassium (K+) and carbon (C). Potassium 62-71 CUP2Q35 Homo sapiens 4-7 33508244-3 2021 Here we report a surprising but crucial function independent of potassium conductance: by organizing the F-actin cytoskeleton in mouse nerve terminals, the Kv3.3 protein facilitates slow endocytosis, rapid endocytosis, vesicle mobilization to the readily releasable pool, and recovery of synaptic depression during repetitive firing. Potassium 64-73 potassium voltage gated channel, Shaw-related subfamily, member 3 Mus musculus 156-161 34001444-4 2021 RESULTS: Endometriosis was associated with increased thrombin generation, reflected by both higher F1+2 (+96.1%, P = 0.005) and ETP (+14.2%, P = 0.014) along with unfavourably altered fibrin clot properties represented by lower Ks (-31%, P < 0.001) and prolonged CLT (+13.5%, P = 0.02), compared with the non-endometriosis group. Potassium 228-230 coagulation factor II, thrombin Homo sapiens 53-61 33239270-2 2021 The K+-Cl- cotransporter KCC2 is responsible for Cl- extrusion and restoration of [Cl-]i equilibrium (ECl) after synaptic activity, but at the cost of increased extracellular potassium which may retard K+-Cl- extrusion, depolarize neurons, and potentiate seizures. Potassium 175-184 solute carrier family 12 member 5 Homo sapiens 25-29 33752589-4 2021 Ka and Ks analyses revealed that in G. hirsutum ARF genes have undergone asymmetric evolution in the two subgenomes. Potassium 7-9 ADP-ribosylation factor 2-B Gossypium hirsutum 48-51 33040444-0 2021 Letrozole targets the Human ether-a-go-go-related gene (HERG) potassium current in glioblastoma. Potassium 62-71 potassium voltage-gated channel subfamily H member 2 Homo sapiens 56-60 33450182-4 2021 However, the drug inhibition mechanism remains unclear because of the scarce structural information regarding the drug- and potassium-bound hERG channels. Potassium 124-133 ETS transcription factor ERG Homo sapiens 140-144 33450182-5 2021 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium 54-63 ETS transcription factor ERG Homo sapiens 70-74 33450182-5 2021 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium 54-63 ETS transcription factor ERG Homo sapiens 123-127 33394730-7 2021 This chloride-sensing mechanism requires basolateral potassium and chloride channels or cotransporters, including Kir4.1/5.1, ClC-Kb, and possibly KCCs, to modulate [Cl-]i in response to the changes of plasma potassium. Potassium 53-62 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 114-124 33111209-1 2021 BACKGROUND: Hydrogen/potassium ATPase beta (ATP4B) is a proton pump acting an essential role in gastric acid secretion. Potassium 21-30 ATPase H+/K+ transporting subunit beta Homo sapiens 44-49 33542107-0 2021 Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium. Potassium 132-141 solute carrier family 12 member 3 Homo sapiens 43-50 33394730-7 2021 This chloride-sensing mechanism requires basolateral potassium and chloride channels or cotransporters, including Kir4.1/5.1, ClC-Kb, and possibly KCCs, to modulate [Cl-]i in response to the changes of plasma potassium. Potassium 53-62 chloride channel, voltage-sensitive Kb Mus musculus 126-132 33394730-9 2021 The understanding of chloride-mediated regulation of WNK4 explains the inverse relationship between dietary potassium intake and NCC activity. Potassium 108-117 WNK lysine deficient protein kinase 4 Mus musculus 53-57 33542107-11 2021 CONCLUSIONS: This study provides evidence that heterozygosity for a pathogenic variant in SLC12A3 causing Gitelman syndrome, a canonically recessive disorder, contributes to serum potassium concentration. Potassium 180-189 solute carrier family 12 member 3 Homo sapiens 90-97 33229908-3 2021 Various approaches are used to overcome this drawback, including the injection of a "synthetic" inward rectifier potassium current (IK1), which is computed in real time, based on the recorded membrane potential ("dynamic clamp"). Potassium 113-122 IKAROS family zinc finger 1 Homo sapiens 132-135 33346797-3 2021 Upregulated LRRC55 and increased intracellular Ca2+ led to BK channel activation and the loss of intracellular potassium, resulting in apoptosome formation and caspase-3 activation in angiotensin II (Ang II)-treated podocytes. Potassium 111-120 leucine rich repeat containing 55 Homo sapiens 12-18 33346797-3 2021 Upregulated LRRC55 and increased intracellular Ca2+ led to BK channel activation and the loss of intracellular potassium, resulting in apoptosome formation and caspase-3 activation in angiotensin II (Ang II)-treated podocytes. Potassium 111-120 angiotensinogen Homo sapiens 184-198 33393091-4 2021 Here, we examined the effect of TRPV4 activation on the delayed rectifier potassium current (IK) in hippocampal pyramidal neurons and on the Kv subunits expression in male mice. Potassium 74-83 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 32-37 33708784-7 2021 Moreover, two new potassium-lowering therapies have shown to improve tolerance, allowing for higher dosage of renin-angiotensin system inhibitors and therefore enhancing their nephroprotective effect. Potassium 18-27 renin Homo sapiens 110-115 33606926-16 2021 Patients with reported high critical serum potassium values were characterized by high rates of comorbidity, reduced eGFR, and mortality. Potassium 43-52 epidermal growth factor receptor Homo sapiens 117-121 33763649-4 2021 A fundamental mechanism underlying functional hyperemia is activation of capillary endothelial inward-rectifying K+ (Kir2.1) channels by neuronally derived potassium (K+), which evokes a retrograde capillary-to-arteriole electrical signal that dilates upstream arterioles, increasing blood delivery to downstream active regions. Potassium 156-165 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 117-123 33679687-9 2020 In vivo, administration of glucose-insulin-potassium reduced serum IL-1beta level, intestinal ASC speck formation, local macrophage infiltration and alleviated intestinal injury in mice exposed to LPS. Potassium 43-52 interleukin 1 alpha Mus musculus 67-75 33679687-9 2020 In vivo, administration of glucose-insulin-potassium reduced serum IL-1beta level, intestinal ASC speck formation, local macrophage infiltration and alleviated intestinal injury in mice exposed to LPS. Potassium 43-52 PYD and CARD domain containing Homo sapiens 94-97 33599929-4 2021 The variance analysis method was used to analyze the difference in the soil pH values, soil organic matter (SOM) content, soil total nitrogen (STN) content, soil available phosphorus (SAP) content and soil available potassium (SAK) content of the reconstructed soil, and the reasons for the difference were discussed. Potassium 216-225 Sak kinase Drosophila melanogaster 227-230 33604622-2 2021 In this study, we investigate the effects of ammonium and potassium on the activity of maize GDH. Potassium 58-67 glutamic dehydrogenase1 Zea mays 93-96 33604622-3 2021 Our results show that both ammonium and potassium play multiple roles in regulating the activity of maize GDH, with the specific roles depending on the concentration of potassium. Potassium 40-49 glutamic dehydrogenase1 Zea mays 106-109 33604622-3 2021 Our results show that both ammonium and potassium play multiple roles in regulating the activity of maize GDH, with the specific roles depending on the concentration of potassium. Potassium 169-178 glutamic dehydrogenase1 Zea mays 106-109 33604622-4 2021 Together with the structural information of GDH, we propose models for the substrate inhibition of ammonium, and the elimination of substrate inhibition by potassium. Potassium 156-165 glutamic dehydrogenase1 Zea mays 44-47 33604622-6 2021 We also analyze the binding sites of ammonium and potassium on maize GDH, and the conformational changes of maize GDH. Potassium 50-59 glutamic dehydrogenase1 Zea mays 69-72 33604622-7 2021 The findings provide insight into the regulation of maize GDH activity by ammonium and potassium and reveal the importance of the dose and ratio of nitrogen and potassium in crop cultivation. Potassium 87-96 glutamic dehydrogenase1 Zea mays 58-61 33604622-7 2021 The findings provide insight into the regulation of maize GDH activity by ammonium and potassium and reveal the importance of the dose and ratio of nitrogen and potassium in crop cultivation. Potassium 161-170 glutamic dehydrogenase1 Zea mays 58-61 33080499-5 2021 This demonstrates that the Ge@C-CMK electrode possesses promising application potential as an alternative anode in sodium and potassium ion storage applications. Potassium 126-135 C-X-C motif chemokine ligand 9 Homo sapiens 32-35 33268067-0 2021 Boosting potassium-ion storage in large-diameter carbon nanotubes/MoP hybrid. Potassium 9-18 opioid receptor mu 1 Homo sapiens 66-69 33633824-1 2021 Background: The urinary sodium potassium (NaK) ratio is associated with dietary sodium and potassium intake and blood pressure, and it also reflects the activity of aldosterone. Potassium 31-40 TANK binding kinase 1 Homo sapiens 42-45 33633824-8 2021 Conclusions: uPA patients with a lower urinary NaK ratio, due to high plasma aldosterone and low serum potassium concentrations, were more likely to have clinical success after adrenalectomy. Potassium 103-112 TANK binding kinase 1 Homo sapiens 47-50 33570024-2 2021 Glycyrrhizin in licorice root activates the renal mineralocorticoid receptor increasing sodium reabsorption and potassium excretion. Potassium 112-121 nuclear receptor subfamily 3 group C member 2 Homo sapiens 50-76 32987266-3 2021 In this work, we have focused on the design and synthesis of a pentacyano organic anion and potassium cation based 3D coordination polymer (5CNP). Potassium 92-101 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 141-144 33542419-1 2021 Soil available phosphorus (SAP) and soil available potassium (SAK) are important elements in the growth of plants. Potassium 51-60 polo like kinase 4 Homo sapiens 62-65 33854899-0 2021 Ultrafine MoP Nanoparticle Splotched Nitrogen-Doped Carbon Nanosheets Enabling High-Performance 3D-Printed Potassium-Ion Hybrid Capacitors. Potassium 107-116 opioid receptor mu 1 Homo sapiens 10-13 33854899-5 2021 It is further confirmed via density functional theory calculations that the smaller the MoP nanoparticle, the larger the three-phase boundary achieved for favoring competitive binding energy toward potassium ions. Potassium 198-207 opioid receptor mu 1 Homo sapiens 88-91 33416459-0 2021 Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. Potassium 59-68 caveolin 3 Mus musculus 0-10 33416459-0 2021 Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. Potassium 59-68 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 80-94 33416459-1 2021 Angiotensin II (AngII) is a key mediator of the renin-angiotensin system and plays an important role in the regulation of cardiac electrophysiology by affecting various cardiac ion currents, including transient outward potassium current Ito. Potassium 219-228 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-14 33416459-1 2021 Angiotensin II (AngII) is a key mediator of the renin-angiotensin system and plays an important role in the regulation of cardiac electrophysiology by affecting various cardiac ion currents, including transient outward potassium current Ito. Potassium 219-228 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 16-21 33144140-9 2021 GENERAL SIGNIFICANCE: Potassium/sodium ion balance or resveratrol binding can act to regulate G4 molecular switches for controlling SGK1 gene expression, thereby presenting a new avenue for drug development. Potassium 22-31 serum/glucocorticoid regulated kinase 1 Homo sapiens 132-136 33390050-0 2021 Thiazide-Sensitive NCC (Sodium-Chloride Cotransporter) in Human Metabolic Syndrome: Sodium Sensitivity and Potassium-Induced Natriuresis. Potassium 107-116 solute carrier family 12 member 3 Homo sapiens 19-22 33144140-5 2021 RT-PCR and Western blot were employed to study the effects of potassium and resveratrol on the SGK1 isoform expression. Potassium 62-71 serum/glucocorticoid regulated kinase 1 Homo sapiens 95-99 33144140-6 2021 RESULTS: The SGK1 gene encodes a G4 structure in the proximal upstream of promoter-2; the G4 structure is stabilized by potassium or resveratrol, but destabilized by sodium. Potassium 120-129 serum/glucocorticoid regulated kinase 1 Homo sapiens 13-17 33144140-7 2021 Super-physiological levels of sodium stimulate the transcription of all SGK1 isoforms, whereas resveratrol or potassium supplementation inhibits the transcription of iso-2 and iso-3, but not iso-1. Potassium 110-119 eukaryotic translation initiation factor 1 Homo sapiens 191-196 33144140-8 2021 CONCLUSIONS: Stabilizing the G4 by potassium or resveratrol induces alternative promoter usage and/or pre-mRNA splicing in the transcription of SGK1. Potassium 35-44 serum/glucocorticoid regulated kinase 1 Homo sapiens 144-148 33390050-4 2021 Conversely, oral potassium induces NCC downregulation producing potassium-induced natriuresis. Potassium 64-73 solute carrier family 12 member 3 Homo sapiens 35-38 33390050-4 2021 Conversely, oral potassium induces NCC downregulation producing potassium-induced natriuresis. Potassium 17-26 solute carrier family 12 member 3 Homo sapiens 35-38 33507417-13 2021 There were positive correlations between SIRT1 levels and each of the hemoglobin levels and serum potassium levels. Potassium 98-107 sirtuin 1 Homo sapiens 41-46 33572566-10 2021 Knowledge gained from structural and functional studies using activators or inhibitors of the potassium current mediated by KV4/KChIPs will better help understand the underlying mechanism involving KV4-mediated-channelopathies, establishing the foundations for drug discovery, and hence their treatments. Potassium 94-103 potassium voltage-gated channel subfamily C member 1 Homo sapiens 124-127 33572566-10 2021 Knowledge gained from structural and functional studies using activators or inhibitors of the potassium current mediated by KV4/KChIPs will better help understand the underlying mechanism involving KV4-mediated-channelopathies, establishing the foundations for drug discovery, and hence their treatments. Potassium 94-103 potassium voltage-gated channel subfamily C member 1 Homo sapiens 198-201 33509163-7 2021 We also demonstrate that this decrease in potassium current lowers the threshold for denatonium to stimulate human beta-defensin-2 release. Potassium 42-51 defensin beta 4B Homo sapiens 115-130 33047410-5 2021 Plants acquire more NO3 - than NH4 + when accumulating high potassium (K), calcium (Ca), and magnesium (Mg) to maintain charge balance. Potassium 60-69 NBL1, DAN family BMP antagonist Homo sapiens 20-23 33614016-7 2021 The main ions involved in PH are calcium ion (Ca2+), potassium ion (K+), sodium ion (Na+) and chloride ion (Cl-). Potassium 53-62 phenylalanine hydroxylase Homo sapiens 26-28 33498651-1 2021 KCNQ1 encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Potassium 32-41 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-5 33499915-0 2021 A nutrient pattern characterized by vitamin A, C, B6, potassium, and fructose is associated with reduced risk of insulin-related disorders: A prospective study among participants of Tehran lipid and glucose study. Potassium 54-63 insulin Homo sapiens 113-120 33499915-13 2021 CONCLUSIONS: Present study showed that high adherence to a nutrient pattern rich in vitamin A, vitamin C, pyridoxine, potassium, and fructose is inversely associated with 3-years changes in insulin, HOMA-IR, and directly associated with HOMA-S. Potassium 118-127 insulin Homo sapiens 190-197 33546058-7 2021 OUTCOMES: Her blood pressure, serum potassium, and plasma renin levels were reversed after treatment with angiotensin-converting enzyme inhibitors. Potassium 36-45 angiotensin I converting enzyme Homo sapiens 106-135 33373586-2 2021 The pore-forming alpha-subunit KCNQ1, which belongs to the voltage-gated ion channel superfamily, associates to its beta-auxiliary subunit KCNE1 to generate the slow cardiac potassium IKs current, whose dysfunction leads to cardiac arrhythmia. Potassium 174-183 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 31-36 33373586-2 2021 The pore-forming alpha-subunit KCNQ1, which belongs to the voltage-gated ion channel superfamily, associates to its beta-auxiliary subunit KCNE1 to generate the slow cardiac potassium IKs current, whose dysfunction leads to cardiac arrhythmia. Potassium 174-183 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 139-144 33628092-12 2021 The activation of nuclear factor-kappaB (NF-kappaB) increased the expression of pro-inflammatory cytokines, and sodium-potassium-chloride co-transporter isoform 1 (NKCC1). Potassium 119-128 nuclear factor kappa B subunit 1 Homo sapiens 18-39 33628092-12 2021 The activation of nuclear factor-kappaB (NF-kappaB) increased the expression of pro-inflammatory cytokines, and sodium-potassium-chloride co-transporter isoform 1 (NKCC1). Potassium 119-128 nuclear factor kappa B subunit 1 Homo sapiens 41-50 33628092-12 2021 The activation of nuclear factor-kappaB (NF-kappaB) increased the expression of pro-inflammatory cytokines, and sodium-potassium-chloride co-transporter isoform 1 (NKCC1). Potassium 119-128 solute carrier family 12 member 2 Homo sapiens 164-169 33498219-0 2021 MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake. Potassium 67-76 serine/threonine kinase 24 Mus musculus 0-4 33889232-12 2021 In contrast, the correlation between serum potassium and serum albumin and that between serum potassium and serum calcium was not significant. Potassium 43-52 albumin Homo sapiens 63-70 33431687-10 2021 These results demonstrate that normal potassium flux through LRRC26-associated BK channels in GCs has protective effects against colitis in mice. Potassium 38-47 leucine rich repeat containing 26 Mus musculus 61-67 33467005-5 2021 Spectral, functional and structural characterization of the inhibitory complexes showed that a one-atom head-group linker elongation, from pyridyl-ethyl to pyridyl-propyl, was beneficial and markedly improved Ks, IC50 and thermostability of CYP3A4. Potassium 209-211 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 241-247 33435938-11 2021 With RNAseq transcriptomic analysis of the expression profiling from the muscle specimens, it surprisingly discloses large downregulation of genes involved in pathways of sodium, potassium, and calcium channels, which can be rescued by L-carnitine treatment, fatty acid metabolism was differentially dysregulated in TPM3(E151G) fish and rescued by L-carnitine treatment. Potassium 179-188 tropomyosin 3 Homo sapiens 316-320 33436713-8 2021 The main independent risk factors associated with 72-h mortality among patients with AST levels >= 3000 U/L included higher serum values of alkaline phosphatase, creatine kinase, serum sodium, potassium, and phosphorus. Potassium 193-202 solute carrier family 17 member 5 Homo sapiens 85-88 33440655-6 2021 Electrophysiological experiments further revealed that AEG-1 further regulates TWIK-1-mediated potassium currents in normal astrocytes. Potassium 95-104 metadherin Homo sapiens 55-60 33440655-6 2021 Electrophysiological experiments further revealed that AEG-1 further regulates TWIK-1-mediated potassium currents in normal astrocytes. Potassium 95-104 potassium two pore domain channel subfamily K member 1 Homo sapiens 79-85 33585337-7 2021 We also discuss the clinical approach and the specificities of managing this rare hereditary renal tubulopathy.. LEARNING POINTS: Gitelman syndrome is a rare cause of persistent hypokalaemia.A definitive diagnosis is determined by the identification of mutations in the SLC12A3 gene.Management consists of chronic potassium and magnesium supplementation aimed at symptom control. Potassium 314-323 solute carrier family 12 member 3 Homo sapiens 270-277 32634539-9 2021 In striatum, basal extracellular levels and potassium-evoked DA release were significantly reduced in mice lacking Casp3, a clear indication of dopaminergic hypofunction in dopaminergic innervating tissues. Potassium 44-53 caspase 3 Mus musculus 115-120 33718604-10 2021 The patient"s ACTH hypersecretion and hypokalemia were treated with potassium replacement, amiloride, and ketoconazole. Potassium 68-77 proopiomelanocortin Homo sapiens 14-18 33412877-2 2021 Like in the well-established direct random phase approximation (dRPA), sigma-functionals require as input exclusively eigenvalues sigma of the frequency-dependent KS response function. Potassium 163-165 Replication Protein A 70 Drosophila melanogaster 64-68 33112610-1 2021 Variants of the SLC24A5 gene, which encodes a putative potassium-dependent sodium-calcium exchanger (NCKX5) that most likely resides in the melanosome or its precursor, affect pigmentation in both humans and zebrafish (Danio rerio). Potassium 55-64 solute carrier family 24 member 5 Homo sapiens 16-23 33112610-1 2021 Variants of the SLC24A5 gene, which encodes a putative potassium-dependent sodium-calcium exchanger (NCKX5) that most likely resides in the melanosome or its precursor, affect pigmentation in both humans and zebrafish (Danio rerio). Potassium 55-64 solute carrier family 24 member 5 Homo sapiens 101-106 33402705-0 2021 FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents. Potassium 126-135 forkhead box P1 Mus musculus 0-5 33490276-16 2021 LpqH protein has good immunogenicity and can activate the NLRP3 inflammasome through the potassium efflux pathway without causing cell death. Potassium 89-98 NLR family, pyrin domain containing 3 Mus musculus 58-63 33220920-6 2021 We then identified 9 compounds that inhibited the CYP11B2 expression induced by potassium-mediated depolarization from the validated compound library (3399 compounds). Potassium 80-89 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 50-57 33288445-0 2021 Corrigendum to "Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia" [Auton Neurosci. Potassium 28-37 oxytocin/neurophysin I prepropeptide Homo sapiens 59-67 31904168-0 2021 The MORN domain of Junctophilin2 regulates functional interactions with small-conductance Ca2+ -activated potassium channel subtype2 (SK2). Potassium 106-115 junctophilin 2 Homo sapiens 19-32 31904168-0 2021 The MORN domain of Junctophilin2 regulates functional interactions with small-conductance Ca2+ -activated potassium channel subtype2 (SK2). Potassium 106-115 potassium calcium-activated channel subfamily N member 2 Homo sapiens 134-137 33498651-1 2021 KCNQ1 encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Potassium 32-41 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 55-60 33498651-1 2021 KCNQ1 encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Potassium 32-41 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 76-82 33498651-1 2021 KCNQ1 encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Potassium 32-41 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 86-91 33518654-14 2021 Similarly, Potassium Inwardly Rectifying Channel Subfamily J Member 6 (KCNJ6) was enriched in the function of an ion channel complex. Potassium 11-20 potassium inwardly rectifying channel subfamily J member 6 Homo sapiens 71-76 32888379-4 2021 Computer calculations were performed using pharmacokinetic and pharmacodynamic data, including affinity to block the rapid component of the delayed rectifier cardiac potassium current (IKr ) encoded by the human ether-a-go-go gene (hERG), propensity to prolong cardiac repolarization (QT interval) and cause torsade de pointes (TdP). Potassium 166-175 ETS transcription factor ERG Homo sapiens 232-236 33357781-5 2021 It is well known that extracellular glutamate levels and glutamate intrasynaptic time-coursing are maintained by perisynaptic astrocytes, where inwardly rectifying potassium channels 4.1 (Kir4.1 channels) regulate both potassium and glutamate uptake. Potassium 164-173 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 188-194 33124684-4 2021 Neurons dissected from YFP-GIRK1 mice had significantly reduced potassium currents and this mouse line phenotypically resembled GIRK1 null mice, making it a "functional knockdown" model of GIRK1-containing channels. Potassium 64-73 potassium inwardly-rectifying channel, subfamily J, member 3 Mus musculus 27-32 33357781-6 2021 In addition, ketamine reduces membrane expression of Kir4.1 channels, which raises extracellular potassium and glutamate levels, increasing postsynaptic neural activities. Potassium 97-106 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 53-59 32998136-11 2021 For example, the serum potassium level in the FMO3 E308G genotype group was significantly lower than that in the WT group (p = 0.028), the abnormal level of total bilirubin in the FMO3 E308G genotype group was significantly higher than that in the WT group (p = 0.049), and the aspartate aminotransferase level in the E308G group was significantly higher than that in the WT group (p = 0.05). Potassium 23-32 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 46-50 33367898-4 2021 In Arabidopsis, the CIPK23 kinase has emerged as a major hub driving root responses to diverse environmental stresses including drought, salinity and nutrient imbalances such as potassium, nitrate and iron deficiencies as well as ammonium, magnesium and non-iron metals toxicities. Potassium 178-187 CBL-interacting protein kinase 23 Arabidopsis thaliana 20-26 33132203-3 2021 The voltage-gated potassium channel KV2.1, encoded by KCNB1, is primarily responsible for delayed rectifier potassium currents that are important regulators of excitability in electrically excitable cells, including neurons. Potassium 18-27 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 36-41 33132203-3 2021 The voltage-gated potassium channel KV2.1, encoded by KCNB1, is primarily responsible for delayed rectifier potassium currents that are important regulators of excitability in electrically excitable cells, including neurons. Potassium 18-27 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 54-59 33132203-4 2021 In addition to its canonical role as a voltage-gated potassium conductance, KV2.1 also serves a highly conserved structural function organizing endoplasmic reticulum-plasma membrane junctions clustered in the soma and proximal dendrites of neurons. Potassium 53-62 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 76-81 32553901-1 2021 TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K2P) channels mediate background potassium currents and regulate cellular excitability in many different types of cells. Potassium 49-58 potassium two pore domain channel subfamily K member 2 Homo sapiens 25-31 33424762-1 2020 Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability. Potassium 20-29 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 80-99 33424762-3 2020 Specifically, Kir4.1 channel inhibition by KCNJ10 gene mutation or expressional down-regulation increases the extracellular levels of potassium ions and glutamate in synapses and causes hyperexcitation of neurons. Potassium 134-143 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 14-20 33424762-3 2020 Specifically, Kir4.1 channel inhibition by KCNJ10 gene mutation or expressional down-regulation increases the extracellular levels of potassium ions and glutamate in synapses and causes hyperexcitation of neurons. Potassium 134-143 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 43-49 33419247-3 2020 There is substantial evidence that c-peptide counteracts the detrimental changes caused by hyperglycemia at the cellular level, such as decreased activation of endothelial nitric oxide synthase and sodium potassium ATPase, and increase in formation of pro-inflammatory molecules mediated by nuclear factor kappa-light-chain-enhancer of activated B cells: cytokines, chemokines, cell adhesion molecules, vascular endothelial growth factor, and transforming growth factor beta. Potassium 205-214 insulin Homo sapiens 35-44 33437379-4 2020 Potassium currents were recorded by whole-cell patch clamping in HEK293 cells transiently transfected with wild-type and/or mutant hERG potassium channel. Potassium 0-9 ETS transcription factor ERG Homo sapiens 131-135 33310850-1 2020 Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume regulation, auditory system function, and gamma-aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission. Potassium 77-86 solute carrier family 12 member 4 Homo sapiens 34-38 33310850-1 2020 Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume regulation, auditory system function, and gamma-aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission. Potassium 77-86 solute carrier family 12 member 7 Homo sapiens 42-46 33363455-15 2020 The levels of inwardly rectifying potassium (Kir 4.1) channels were also downregulated in astrocytes in the WT post-PTZ, while its levels did not change in KO groups. Potassium 34-43 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 45-52 33424864-0 2020 Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation. Potassium 41-50 NLR family pyrin domain containing 3 Homo sapiens 62-67 33424864-2 2020 Potassium efflux has been reported to be essential for NLRP3 inflammasome activation by structurally diverse pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Potassium 0-9 NLR family pyrin domain containing 3 Homo sapiens 55-60 33424864-3 2020 Thus, the molecular mechanisms underlying potassium efflux to activate NLRP3 inflammasome are under extensive investigation. Potassium 42-51 NLR family pyrin domain containing 3 Homo sapiens 71-76 33424864-4 2020 Here, we review current knowledge about the distinction channels or pore-forming proteins underlying potassium efflux for NLRP3 inflammasome activation with canonical/non-canonical signaling or following caspase-8 induced pyroptosis. Potassium 101-110 NLR family pyrin domain containing 3 Homo sapiens 122-127 33424864-4 2020 Here, we review current knowledge about the distinction channels or pore-forming proteins underlying potassium efflux for NLRP3 inflammasome activation with canonical/non-canonical signaling or following caspase-8 induced pyroptosis. Potassium 101-110 caspase 8 Homo sapiens 204-213 33362470-8 2020 Importantly, NGN2iSNs repetitively fire action potentials (APs) supported by voltage-gated sodium, potassium, and calcium conductances. Potassium 99-108 neurogenin 2 Rattus norvegicus 13-17 33343935-9 2020 The negative association between SP-A1 and Ks was found in mild, moderate, and severe keratoconus eyes (r mild = -0.171, r moderate = -0.317, r severe = -0.288, all P < 0.05). Potassium 43-45 surfactant protein A1 Homo sapiens 33-38 33035439-12 2020 Our results suggest that redox-activated PKA may be important for H2O2-dependent arrhythmias and could be important for the development of specific antiarrhythmic drugs.NEW & NOTEWORTHY Oxidation-activated PKA type I inhibits transient outward potassium current (Ito) and inward rectifying potassium current (IK1) and contributes to ROS-induced APD prolongation as well as generation of early afterdepolarizations in murine ventricular cardiomyocytes. Potassium 244-253 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 309-312 33035439-12 2020 Our results suggest that redox-activated PKA may be important for H2O2-dependent arrhythmias and could be important for the development of specific antiarrhythmic drugs.NEW & NOTEWORTHY Oxidation-activated PKA type I inhibits transient outward potassium current (Ito) and inward rectifying potassium current (IK1) and contributes to ROS-induced APD prolongation as well as generation of early afterdepolarizations in murine ventricular cardiomyocytes. Potassium 290-299 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 309-312 33323459-2 2020 Recent studies suggest NIMA-related kinase 7 (NEK7) is necessary for NLRP3 inflammasome activation during potassium efflux. Potassium 106-115 NIMA related kinase 7 Homo sapiens 23-44 33323459-2 2020 Recent studies suggest NIMA-related kinase 7 (NEK7) is necessary for NLRP3 inflammasome activation during potassium efflux. Potassium 106-115 NIMA related kinase 7 Homo sapiens 46-50 33323459-2 2020 Recent studies suggest NIMA-related kinase 7 (NEK7) is necessary for NLRP3 inflammasome activation during potassium efflux. Potassium 106-115 NLR family pyrin domain containing 3 Homo sapiens 69-74 32990398-9 2020 Functional verification showed that the KCNAB3 mutation could accelerate the inactivation of potassium channels, thus inhibiting potassium current, increasing neuronal excitability, and promoting epileptic convulsion. Potassium 93-102 potassium voltage-gated channel subfamily A regulatory beta subunit 3 Homo sapiens 40-46 32253972-2 2020 A frequent cause for LQTS are mutations in the KCNH2 gene (also known as the human ether-a-go-go-related gene or hERG), which reduce or modulate the potassium current IKr and hence alter cardiac repolarization. Potassium 149-158 potassium voltage-gated channel subfamily H member 2 Homo sapiens 47-52 32253972-2 2020 A frequent cause for LQTS are mutations in the KCNH2 gene (also known as the human ether-a-go-go-related gene or hERG), which reduce or modulate the potassium current IKr and hence alter cardiac repolarization. Potassium 149-158 ETS transcription factor ERG Homo sapiens 113-117 32617840-0 2020 GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation. Potassium 35-44 potassium inwardly-rectifying channel, subfamily J, member 3 Mus musculus 0-5 32307195-10 2020 A 20-mmol increase in potassium intake during follow-up was associated with a 24% reduction in renal outcome. Potassium 22-31 immunoglobulin kappa variable 1-27 Homo sapiens 0-4 32307195-10 2020 A 20-mmol increase in potassium intake during follow-up was associated with a 24% reduction in renal outcome. Potassium 22-31 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 76-80 32075457-5 2020 We have found a unique Nrf2 inactivator, named K67, that inhibited the PPI between Keap1 and p-p62 and attenuated sorafenib resistance in Huh-1 cells. Potassium 47-50 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 32075457-5 2020 We have found a unique Nrf2 inactivator, named K67, that inhibited the PPI between Keap1 and p-p62 and attenuated sorafenib resistance in Huh-1 cells. Potassium 47-50 kelch like ECH associated protein 1 Homo sapiens 83-88 32075457-5 2020 We have found a unique Nrf2 inactivator, named K67, that inhibited the PPI between Keap1 and p-p62 and attenuated sorafenib resistance in Huh-1 cells. Potassium 47-50 docking protein 1 Homo sapiens 93-98 32621119-6 2020 MLKL-induced caspase-1 activation and IL-1beta maturation were abolished by NLR family, pyrin domain-containing 3 (NLRP3) specific inhibitor MCC950, or extracellular high potassium concentration. Potassium 171-180 mixed lineage kinase domain like pseudokinase Homo sapiens 0-4 32621119-6 2020 MLKL-induced caspase-1 activation and IL-1beta maturation were abolished by NLR family, pyrin domain-containing 3 (NLRP3) specific inhibitor MCC950, or extracellular high potassium concentration. Potassium 171-180 caspase 1 Homo sapiens 13-22 32790646-7 2020 Together, these new WNK1 genetic variants highlight the importance of the KS-WNK1 isoform abundance on potassium homeostasis. Potassium 103-112 WNK lysine deficient protein kinase 1 Mus musculus 20-24 32790646-7 2020 Together, these new WNK1 genetic variants highlight the importance of the KS-WNK1 isoform abundance on potassium homeostasis. Potassium 103-112 WNK lysine deficient protein kinase 1 Mus musculus 77-81 33070272-3 2020 Since acid-base balance is closely linked to potassium metabolism, in the present work we aim to determine the effect of chronic metabolic acidosis (CMA) and hyperkalemia (HK) on protein abundance and localization of HCN3 in the rat kidney. Potassium 45-54 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Rattus norvegicus 217-221 33070272-12 2020 These findings further support HCN channels contribution to renal acid-base and potassium balance. Potassium 80-89 cyclic nucleotide gated channel subunit alpha 1 Rattus norvegicus 31-34 33127441-5 2020 This impairment was abolished in the presence of voltage-gated potassium (KV1) channel blocker 4-aminopyridine, or by application of heparin-binding EGF-like growth factor (HB-EGF), which promotes KV1 channel down-regulations. Potassium 63-72 heparin-binding EGF-like growth factor Mus musculus 173-179 33321932-3 2020 Patch-clamp recordings of goblet cells located in freshly excised rat conjunctiva reveal that these mucin-releasing cells respond to sustained hyperosmolarity by sequentially activating their ATP-sensitive potassium (KATP), nonspecific cation (NSC), voltage-gated calcium (VGCC), and P2X7 channels; each of which modulates exocytosis. Potassium 206-215 solute carrier family 13 member 2 Rattus norvegicus 100-105 33328867-6 2020 In this review we propose that a residual fraction of functionally active Kir4.1 channels mediates a small, but continuous, efflux of potassium at the more depolarized RMP of GBM cells. Potassium 134-143 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 74-80 33255956-5 2020 Monopotassium salts of homopolyether-diols, i.e., PPO-diol, PBO-diol, and PAGE-diol, appeared to be useful macroinitiators for the preparation of new triblock copolyether-diols by polymerization of glycidyl ethers. Potassium 0-13 protoporphyrinogen oxidase Homo sapiens 50-53 33237923-12 2020 Chromogranin A correlated significantly with potassium in patients with neuroendocrine tumors and there was a significant correlation between ACTH level and severity of hypokalemia. Potassium 45-54 chromogranin A Homo sapiens 0-14 25905305-1 2000 Aldosterone promotes active sodium transport and excretion of potassium via the mineralocorticoid receptor (MR) and the resultant activation of specific amiloride-sensitive sodium channels (ENaC) and the Na-K ATP ase pump in the target tissues. Potassium 62-71 nuclear receptor subfamily 3 group C member 2 Homo sapiens 80-106 25905305-1 2000 Aldosterone promotes active sodium transport and excretion of potassium via the mineralocorticoid receptor (MR) and the resultant activation of specific amiloride-sensitive sodium channels (ENaC) and the Na-K ATP ase pump in the target tissues. Potassium 62-71 nuclear receptor subfamily 3 group C member 2 Homo sapiens 108-110 33238639-3 2020 Meanwhile, Cs, Se, and Te were enriched in the phase separated potassium-rich materials on glass surface, which were extracted by water. Potassium 63-72 squalene epoxidase Homo sapiens 15-17 33238639-6 2020 The higher phase separation efficiency of potassium-rich materials led to the higher extraction efficiencies of Cs, Se, and Te in liquid Sb extraction than Bi. Potassium 42-51 squalene epoxidase Homo sapiens 116-118 33329012-3 2020 Due to the prevailing data suggesting that an increased potassium level is a main contributor, we studied the effect of a modulator of a big conductance Ca2+- and voltage-activated K+ channels (BK) modulator on contraction and relaxation of slow- and high-twitch muscle specimen before and after the pharmacological induction of myotonia. Potassium 56-65 synaptotagmin XVII Mus musculus 194-196 33237165-9 2020 The stages of NHL were: I (21%), II (18,4%), III (26,3%), and IV (34,2%), but KS were found only at III (40%) and IV (60%) stages. Potassium 78-80 serpin family C member 1 Homo sapiens 97-103 33228183-4 2020 We observed that the upregulated expression of cardiac gene markers (NKX2-5, MYH6, TNNT2, and DES) and cardiac ion channel genes (sodium, calcium, the potassium) also the increased levels of Connexin 43 and Nkx2.5 proteins. Potassium 151-160 NK2 homeobox 5 Homo sapiens 69-75 33228183-4 2020 We observed that the upregulated expression of cardiac gene markers (NKX2-5, MYH6, TNNT2, and DES) and cardiac ion channel genes (sodium, calcium, the potassium) also the increased levels of Connexin 43 and Nkx2.5 proteins. Potassium 151-160 myosin heavy chain 6 Homo sapiens 77-81 33228183-4 2020 We observed that the upregulated expression of cardiac gene markers (NKX2-5, MYH6, TNNT2, and DES) and cardiac ion channel genes (sodium, calcium, the potassium) also the increased levels of Connexin 43 and Nkx2.5 proteins. Potassium 151-160 troponin T2, cardiac type Homo sapiens 83-88 33228183-4 2020 We observed that the upregulated expression of cardiac gene markers (NKX2-5, MYH6, TNNT2, and DES) and cardiac ion channel genes (sodium, calcium, the potassium) also the increased levels of Connexin 43 and Nkx2.5 proteins. Potassium 151-160 gap junction protein alpha 1 Homo sapiens 191-202 33228183-4 2020 We observed that the upregulated expression of cardiac gene markers (NKX2-5, MYH6, TNNT2, and DES) and cardiac ion channel genes (sodium, calcium, the potassium) also the increased levels of Connexin 43 and Nkx2.5 proteins. Potassium 151-160 NK2 homeobox 5 Homo sapiens 207-213 33312183-7 2020 Compared to the other potassium treatments, the CRK x FA180 treatment increased the seed yield and net profit by 4.29-14.92% and 13.72-62.30%, respectively, over the 2 years. Potassium 22-31 CRK proto-oncogene, adaptor protein Homo sapiens 48-51 33312183-8 2020 The potassium agronomy efficiency and potassium recovery efficiency (KRE) of the CRK x FA180 treatment were also improved by 6.25-30.77% and 3.82-12.78% compared to those of the other potassium treatments. Potassium 4-13 CRK proto-oncogene, adaptor protein Homo sapiens 81-84 33312183-8 2020 The potassium agronomy efficiency and potassium recovery efficiency (KRE) of the CRK x FA180 treatment were also improved by 6.25-30.77% and 3.82-12.78% compared to those of the other potassium treatments. Potassium 38-47 CRK proto-oncogene, adaptor protein Homo sapiens 81-84 33312183-8 2020 The potassium agronomy efficiency and potassium recovery efficiency (KRE) of the CRK x FA180 treatment were also improved by 6.25-30.77% and 3.82-12.78% compared to those of the other potassium treatments. Potassium 38-47 CRK proto-oncogene, adaptor protein Homo sapiens 81-84 33312183-10 2020 The release period of CRK in the field during the growth period of cotton was longer than that detected by 25 C static water extraction, which increased the soil available potassium content and met the potassium demands over the whole cotton growth period. Potassium 172-181 CRK proto-oncogene, adaptor protein Homo sapiens 22-25 33312183-10 2020 The release period of CRK in the field during the growth period of cotton was longer than that detected by 25 C static water extraction, which increased the soil available potassium content and met the potassium demands over the whole cotton growth period. Potassium 202-211 CRK proto-oncogene, adaptor protein Homo sapiens 22-25 33007282-5 2020 The activity of the electrogenic isoform of the cardiac NBC (NBCe1) was estimated by recording intracellular pH under high potassium concentration and by measuring action potential duration (APD). Potassium 123-132 solute carrier family 4 (anion exchanger), member 4 Mus musculus 61-66 33007282-7 2020 Additionally, the APD was shorter and the alkalization due to high extracellular potassium-induced depolarization was greater in this group, indicating that the NBCe1 was hyperactive. Potassium 81-90 solute carrier family 4 (anion exchanger), member 4 Mus musculus 161-166 33183317-4 2020 The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. Potassium 58-67 leptin Rattus norvegicus 14-20 33183317-4 2020 The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. Potassium 58-67 solute carrier family 12 member 5 Rattus norvegicus 86-90 33135287-9 2020 In addition, the GSDMD pore results in potassium efflux that can activate the NLRP3 inflammasome. Potassium 39-48 gasdermin D Mus musculus 17-22 33135287-9 2020 In addition, the GSDMD pore results in potassium efflux that can activate the NLRP3 inflammasome. Potassium 39-48 NLR family, pyrin domain containing 3 Mus musculus 78-83 33147278-1 2020 The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr). Potassium 131-140 ETS transcription factor ERG Homo sapiens 85-89 33016076-14 2020 CONCLUSION: Normal renal function was not associated with true hyperkalaemia, making the eGFR a useful tool in predicting true from pseudohyperkalaemia, especially for potassium results a$6.5 mmol/L. Potassium 168-177 epidermal growth factor receptor Homo sapiens 89-93 33050989-3 2020 We found that potassium efflux is increased in TG-treated THP-1 macrophages and that the inhibition of potassium efflux blocks TG-induced cell death as well as caspase-1 and -2 activation. Potassium 14-23 caspase 1 Homo sapiens 160-176 33050989-3 2020 We found that potassium efflux is increased in TG-treated THP-1 macrophages and that the inhibition of potassium efflux blocks TG-induced cell death as well as caspase-1 and -2 activation. Potassium 103-112 caspase 1 Homo sapiens 160-176 33050989-4 2020 Furthermore, reducing ATP concentration (known to induce potassium efflux), restored cell viability and caspase-1 and -2 activity. Potassium 57-66 caspase 1 Homo sapiens 104-120 33050989-7 2020 These results suggest that TG-induced THP-1 macrophage cell death is induced via pannexin-1 activation, which increases extracellular ATP, leading to an increase in potassium efflux. Potassium 165-174 pannexin 1 Homo sapiens 81-91 32798220-6 2020 We tested possible direct effects on GnRH neurons by altering voltage-gated potassium currents. Potassium 76-85 gonadotropin releasing hormone 1 Mus musculus 37-41 32950535-1 2020 BACKGROUND: Long noncoding RNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) takes part in diabetic cataract progression. Potassium 31-40 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 124-132 32745503-4 2020 The Ka/Ks ratio shows that cox1 has the slowest evolutionary rate. Potassium 7-9 mitochondrially encoded cytochrome c oxidase I Homo sapiens 27-31 32934003-8 2020 Our results also suggest that SBMA and ALS share common axonal excitability changes; increased nodal persistent sodium and reduced potassium currents that may accelerate motor neuronal death and differently affect axons-innervating different muscles. Potassium 131-140 androgen receptor Homo sapiens 30-34 32860887-1 2020 BACKGROUND: The hyperpolarizing activity of gamma-aminobutyric acid A (GABAA) receptors depends on the intracellular chloride gradient that is developmentally regulated by the activity of the chloride extruder potassium (K) chloride (Cl) cotransporter 2 (KCC2). Potassium 210-219 solute carrier family 12 member 5 Rattus norvegicus 255-259 32878973-3 2020 Here, we report the crystal structure of the Reduced Potassium Dependency3/Histone Deacetylase1 (RPD3/HDA1) type class II histone deacetylase HDA15 in Arabidopsis (Arabidopsis thaliana). Potassium 53-62 histone deacetylase 1 Arabidopsis thaliana 102-106 32878973-3 2020 Here, we report the crystal structure of the Reduced Potassium Dependency3/Histone Deacetylase1 (RPD3/HDA1) type class II histone deacetylase HDA15 in Arabidopsis (Arabidopsis thaliana). Potassium 53-62 histone deacetylase 15 Arabidopsis thaliana 142-147 33085076-7 2020 It was observed that subjects presenting an alteration of the gene responsible for the calcium channel, CACNA1S, presented lower serum potassium levels, own triggers and a higher proportion of subjects showing dyspnea during the crisis. Potassium 135-144 calcium voltage-gated channel subunit alpha1 S Homo sapiens 104-111 33079488-0 2020 Structural Engineering of SnS2 Encapsulated in Carbon Nanoboxes for High-Performance Sodium/Potassium-Ion Batteries Anodes. Potassium 92-101 sodium voltage-gated channel alpha subunit 11 Homo sapiens 26-30 32810596-7 2020 Ks correlated inversely with FIX and FV, thrombin-activatable fibrinolysis inhibitor, complement C1s, C7, C8, and apolipoprotein A-I. Potassium 0-2 coagulation factor II, thrombin Homo sapiens 41-49 32810596-7 2020 Ks correlated inversely with FIX and FV, thrombin-activatable fibrinolysis inhibitor, complement C1s, C7, C8, and apolipoprotein A-I. Potassium 0-2 apolipoprotein A1 Homo sapiens 114-132 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 67-76 potassium two pore domain channel subfamily K member 2 Homo sapiens 16-22 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 67-76 potassium two pore domain channel subfamily K member 2 Homo sapiens 24-30 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 93-102 potassium two pore domain channel subfamily K member 2 Homo sapiens 16-22 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 93-102 potassium two pore domain channel subfamily K member 2 Homo sapiens 24-30 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 93-102 potassium two pore domain channel subfamily K member 2 Homo sapiens 16-22 33127683-4 2020 Here, combining K2P2.1 (TREK-1) x-ray crystallography in different potassium concentrations, potassium anomalous scattering, molecular dynamics, and electrophysiology, we uncover unprecedented, asymmetric, potassium-dependent conformational changes that underlie K2P C-type gating. Potassium 93-102 potassium two pore domain channel subfamily K member 2 Homo sapiens 24-30 33121425-2 2021 Laboratory examination revealed that urinary potassium excretion and serum aldosterone level increased, at the same time with hyperthyroidism and thyroid related antibodies positive.Genetic testing showed that there was a complex heterozygous mutation in SLC12A3 gene ,c.1077C>G(p.N359K) and c.1567G>A(p.A523? Potassium 45-54 solute carrier family 12 member 3 Homo sapiens 255-262 33138194-4 2020 The chemically modified, bi-functional anti-EGFR Q-ASO and a 56-nt long EGFR mRNA fragment, in the presence of potassium ions, were shown to form in vitro very stable parallel G-quadruplex containing a 28-nt long external loop folding to two duplex-stem structure. Potassium 111-120 epidermal growth factor receptor Homo sapiens 44-48 33138194-4 2020 The chemically modified, bi-functional anti-EGFR Q-ASO and a 56-nt long EGFR mRNA fragment, in the presence of potassium ions, were shown to form in vitro very stable parallel G-quadruplex containing a 28-nt long external loop folding to two duplex-stem structure. Potassium 111-120 epidermal growth factor receptor Homo sapiens 72-76 33122764-4 2020 Graft size, Kmax and Ks correlated with IHT/CCT and IGT/CCT in the KC group. Potassium 21-23 CCT Homo sapiens 44-47 33122764-4 2020 Graft size, Kmax and Ks correlated with IHT/CCT and IGT/CCT in the KC group. Potassium 21-23 CCT Homo sapiens 56-59 33192566-1 2020 Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing. Potassium 130-139 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 0-5 33192566-1 2020 Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing. Potassium 130-139 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 30-35 33095786-14 2020 The most prominent of these was Hdac1 which may be regulating genes associated with glutamatergic signaling and potassium conductance. Potassium 112-121 histone deacetylase 1 Mus musculus 32-37 32882214-2 2020 Although a previous report showed that quetiapine blocked hERG potassium current, quetiapine has been considered relatively safe in terms of cardiovascular side effects. Potassium 63-72 ETS transcription factor ERG Homo sapiens 58-62 32882214-7 2020 Our results indicate that norquetiapine blocks hNav1.5 current in concentration-, state- and use-dependent manners, suggesting that the blockade of hNav1.5 current by norquetiapine may shorten the cardiac action potential duration and reduce the risk of QT interval prolongation induced by the inhibition of hERG potassium currents. Potassium 313-322 sodium voltage-gated channel alpha subunit 5 Homo sapiens 47-54 32882214-7 2020 Our results indicate that norquetiapine blocks hNav1.5 current in concentration-, state- and use-dependent manners, suggesting that the blockade of hNav1.5 current by norquetiapine may shorten the cardiac action potential duration and reduce the risk of QT interval prolongation induced by the inhibition of hERG potassium currents. Potassium 313-322 sodium voltage-gated channel alpha subunit 5 Homo sapiens 148-155 32736087-0 2020 5-HT7 receptors increase the excitability of hippocampal CA1 pyramidal neurons by inhibiting the A-type potassium current. Potassium 104-113 carbonic anhydrase 1 Rattus norvegicus 57-60 33057440-6 2020 Inhibition of COX-2 in vGPCR-transformed cells impairs vGPCR-driven angiogenesis and treatment with the COX-2-selective inhibitory drug Celecoxib produces a significant decrease in tumor growth, pointing to COX-2 activity as critical for vGPCR oncogenicity in vivo and indicating that COX-2-mediated angiogenesis could play a role in KS tumorigenesis. Potassium 334-336 prostaglandin-endoperoxide synthase 2 Homo sapiens 104-109 33057440-6 2020 Inhibition of COX-2 in vGPCR-transformed cells impairs vGPCR-driven angiogenesis and treatment with the COX-2-selective inhibitory drug Celecoxib produces a significant decrease in tumor growth, pointing to COX-2 activity as critical for vGPCR oncogenicity in vivo and indicating that COX-2-mediated angiogenesis could play a role in KS tumorigenesis. Potassium 334-336 prostaglandin-endoperoxide synthase 2 Homo sapiens 104-109 33057440-6 2020 Inhibition of COX-2 in vGPCR-transformed cells impairs vGPCR-driven angiogenesis and treatment with the COX-2-selective inhibitory drug Celecoxib produces a significant decrease in tumor growth, pointing to COX-2 activity as critical for vGPCR oncogenicity in vivo and indicating that COX-2-mediated angiogenesis could play a role in KS tumorigenesis. Potassium 334-336 prostaglandin-endoperoxide synthase 2 Homo sapiens 104-109 33057440-7 2020 These results, along with the overexpression of COX-2 in KS lesions, define COX-2 as a potential target for the prevention and treatment of KSHV-oncogenesis. Potassium 57-59 prostaglandin-endoperoxide synthase 2 Homo sapiens 48-53 33057440-7 2020 These results, along with the overexpression of COX-2 in KS lesions, define COX-2 as a potential target for the prevention and treatment of KSHV-oncogenesis. Potassium 57-59 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-81 33057457-9 2020 In keeping with functional data, the presence of both TREK-1 and Kir6.1 (potassium selective), as well as TRPM4, TRPV4 and TRPC6 (cationic non-selective) channels was confirmed in VIC at the protein level. Potassium 73-82 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 65-71 33163493-5 2020 Ubiquitous knockdown of CG4928 causes flies to have a reduced secretion rate from the Malpighian tubules; altering potassium content in the body and in the Malpighian tubules, homologous to the renal system; and results in the development of edema. Potassium 115-124 uncharacterized protein Drosophila melanogaster 24-30 33437698-3 2020 TPP is due to increased sodium/potassium ATPase activity during thyrotoxic states, which is due to mutations encoding potassium channels. Potassium 31-40 dynein axonemal heavy chain 8 Homo sapiens 41-47 32840624-7 2020 The most significant locus was rs77958157 near cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) , a gene involved in eating behavior and appetite regulation (P = 2.3 x 10-8 with sodium-to-potassium ratio). Potassium 208-217 CART prepropeptide Homo sapiens 47-106 32840624-7 2020 The most significant locus was rs77958157 near cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) , a gene involved in eating behavior and appetite regulation (P = 2.3 x 10-8 with sodium-to-potassium ratio). Potassium 208-217 CART prepropeptide Homo sapiens 108-114 32840624-8 2020 Two suggestive loci were replicated in additional samples: for sodium excretion, rs12094702 near zinc finger SWIM-type containing 5 (ZSWIM5) was replicated in the Asian ancestry sample reaching Bonferroni-corrected significance (P = 0.007), and for potassium excretion rs34473523 near sodium leak channel (NALCN) was associated at a nominal P value with potassium excretion both in European (P = 0.043) and African (P = 0.043) ancestry cohorts. Potassium 249-258 zinc finger SWIM-type containing 5 Homo sapiens 97-131 32840624-8 2020 Two suggestive loci were replicated in additional samples: for sodium excretion, rs12094702 near zinc finger SWIM-type containing 5 (ZSWIM5) was replicated in the Asian ancestry sample reaching Bonferroni-corrected significance (P = 0.007), and for potassium excretion rs34473523 near sodium leak channel (NALCN) was associated at a nominal P value with potassium excretion both in European (P = 0.043) and African (P = 0.043) ancestry cohorts. Potassium 249-258 zinc finger SWIM-type containing 5 Homo sapiens 133-139 32840624-8 2020 Two suggestive loci were replicated in additional samples: for sodium excretion, rs12094702 near zinc finger SWIM-type containing 5 (ZSWIM5) was replicated in the Asian ancestry sample reaching Bonferroni-corrected significance (P = 0.007), and for potassium excretion rs34473523 near sodium leak channel (NALCN) was associated at a nominal P value with potassium excretion both in European (P = 0.043) and African (P = 0.043) ancestry cohorts. Potassium 354-363 zinc finger SWIM-type containing 5 Homo sapiens 97-131 32840624-8 2020 Two suggestive loci were replicated in additional samples: for sodium excretion, rs12094702 near zinc finger SWIM-type containing 5 (ZSWIM5) was replicated in the Asian ancestry sample reaching Bonferroni-corrected significance (P = 0.007), and for potassium excretion rs34473523 near sodium leak channel (NALCN) was associated at a nominal P value with potassium excretion both in European (P = 0.043) and African (P = 0.043) ancestry cohorts. Potassium 354-363 zinc finger SWIM-type containing 5 Homo sapiens 133-139 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 73-82 serine/threonine protein kinase ATG1 Saccharomyces cerevisiae S288C 251-255 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 73-82 Atg5p Saccharomyces cerevisiae S288C 257-261 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 73-82 phosphatidylinositol 3-kinase VPS34 Saccharomyces cerevisiae S288C 263-268 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 187-196 serine/threonine protein kinase ATG1 Saccharomyces cerevisiae S288C 251-255 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 187-196 Atg5p Saccharomyces cerevisiae S288C 257-261 32788210-3 2020 In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in the yeast Saccharomyces cerevisiae We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of the phosphatidylinositol 3-kinase complex. Potassium 187-196 phosphatidylinositol 3-kinase VPS34 Saccharomyces cerevisiae S288C 263-268 32865974-2 2020 Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus oocytes to measure the kinetics of D2R antagonism by a series of aripiprazole analogues, as well as the recovery of dopamine (DA) responsivity upon washout. Potassium 48-57 potassium inwardly rectifying channel subfamily J member 3 S homeolog Xenopus laevis 59-63 32865974-2 2020 Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus oocytes to measure the kinetics of D2R antagonism by a series of aripiprazole analogues, as well as the recovery of dopamine (DA) responsivity upon washout. Potassium 48-57 dopamine receptor D2 L homeolog Xenopus laevis 130-133 33841871-5 2021 In situ genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was clinically responsive to changes in extracellular potassium. Potassium 166-175 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 52-57 32830538-1 2020 Acyl-CoA synthetase medium-chain family member 2 (Acsm2) gene was first identified and cloned by our group as a kidney-specific "KS" gene. Potassium 129-131 acyl-CoA synthetase medium-chain family member 2 Mus musculus 0-48 32830538-1 2020 Acyl-CoA synthetase medium-chain family member 2 (Acsm2) gene was first identified and cloned by our group as a kidney-specific "KS" gene. Potassium 129-131 acyl-CoA synthetase medium-chain family member 2 Mus musculus 50-55 32765863-1 2020 Hypokalemic periodic paralysis type 1 (OMIM; HOKPP1) and type 2 (OMIM; HOKPP2) are diseases of the muscle characterized by episodes of painless muscle weakness, and is associated with low potassium blood levels. Potassium 188-197 calcium voltage-gated channel subunit alpha1 S Homo sapiens 45-51 32765863-1 2020 Hypokalemic periodic paralysis type 1 (OMIM; HOKPP1) and type 2 (OMIM; HOKPP2) are diseases of the muscle characterized by episodes of painless muscle weakness, and is associated with low potassium blood levels. Potassium 188-197 sodium voltage-gated channel alpha subunit 4 Homo sapiens 71-77 32726456-9 2020 CONCLUSIONS AND IMPLICATIONS: Kir4.1 channels are also target of aminoglycoside antibiotics, which could affect potassium transport in several tissues. Potassium 112-121 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 30-36 32906212-2 2020 For one patient, a cognitively impaired adolescent with a de novo stop-gain VAMP2 mutation, we tested a potential treatment strategy, enhancing neurotransmission by prolonging action potentials with the aminopyridine family of potassium channel blockers, 4-aminopyridine and 3,4-diaminopyridine, in vitro and in vivo. Potassium 227-236 vesicle associated membrane protein 2 Homo sapiens 76-81 32936716-3 2020 However, the role and molecular mechanism of potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) in HCC are still unclear. Potassium 45-54 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 124-132 33004801-5 2020 Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux. Potassium 193-202 TNF superfamily member 13b Homo sapiens 17-21 33004801-5 2020 Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux. Potassium 193-202 NLR family pyrin domain containing 3 Homo sapiens 32-37 33305731-2 2020 Recently, vonoprazan, a novel potassium-competitive acid blocker (P-CAB), has been introduced as more effective treatment option. Potassium 30-39 neural proliferation, differentiation and control 1 Homo sapiens 68-71 32870280-3 2020 In this study, we characterise the G4 formation of a (GGN)13 repeat found within the 5" UTR of the potassium 2-pore domain leak channel Task3 mRNA. Potassium 99-108 gametogenetin Homo sapiens 54-57 32798904-0 2020 Target of rapamycin regulates potassium uptake in Arabidopsis and potato. Potassium 30-39 target of rapamycin Arabidopsis thaliana 0-19 32798904-4 2020 However, it is still unclear whether there is a causative link between the TOR pathway and potassium absorption. Potassium 91-100 target of rapamycin Arabidopsis thaliana 75-78 32798904-5 2020 Here, we show that the expression of some potassium transporters and channels was regulated by TOR, and the suppression of TOR activity significantly affected potassium uptake in Arabidopsis and potato. Potassium 42-51 target of rapamycin Arabidopsis thaliana 95-98 32798904-5 2020 Here, we show that the expression of some potassium transporters and channels was regulated by TOR, and the suppression of TOR activity significantly affected potassium uptake in Arabidopsis and potato. Potassium 42-51 target of rapamycin Arabidopsis thaliana 123-126 32798904-9 2020 In addition, the overexpression of CIPK23 could effectively restore the defects in growth and potassium uptake induced by the TOR inhibitors. Potassium 94-103 CBL-interacting protein kinase 23 Arabidopsis thaliana 35-41 32798904-9 2020 In addition, the overexpression of CIPK23 could effectively restore the defects in growth and potassium uptake induced by the TOR inhibitors. Potassium 94-103 target of rapamycin Arabidopsis thaliana 126-129 32798904-10 2020 Thus, our work reveals a link between TOR signaling and CIPK23 and provides new insight into the regulation of potassium uptake in plants. Potassium 111-120 target of rapamycin Arabidopsis thaliana 38-41 32798904-10 2020 Thus, our work reveals a link between TOR signaling and CIPK23 and provides new insight into the regulation of potassium uptake in plants. Potassium 111-120 CBL-interacting protein kinase 23 Arabidopsis thaliana 56-62 32999428-6 2020 CBD inhibited hERG potassium channels with an IC50 value of 2.07 microM at room temperature and delayed rectifier potassium current with 6.5 microM at 37 C, respectively. Potassium 19-28 ETS transcription factor ERG Homo sapiens 14-18 32870280-4 2020 Biophysical analyses show that this (GGN)13 repeat forms a parallel G4 in vitro exhibiting the stereotypical potassium specificity of G4s, remaining thermostable under physiological ionic conditions. Potassium 109-118 gametogenetin Homo sapiens 37-40 32842723-3 2020 The synergism in structural and chemical framework, along with open-ended morphology, enables bifunctionality of hard-carbon NCF as symmetric adsorptive electrodes for supercapacitors and intercalation anodes for hybrid potassium ion capacitors (KICs). Potassium 220-229 neutrophil cytosolic factor 4 Homo sapiens 125-128 32629001-5 2020 In addition, the prolongation of the corrected QT (QTc) interval under CMUS that increased vulnerability to VAs was significantly attenuated by stimulation of S1R due to the decreased amplitude of L-type calcium current (ICa-L) and the restoration of reduced transient outward potassium current (Ito) resulting from CMUS induction. Potassium 277-286 sigma non-opioid intracellular receptor 1 Rattus norvegicus 159-162 32973172-1 2020 Na+-K+-2Cl- Cotransporter (NKCC1) is a protein that aids in the active transport of sodium, potassium, and chloride ions across cell membranes. Potassium 92-101 solute carrier family 12 member 2 Homo sapiens 27-32 32946686-11 2020 Furthermore, it was shown by voltage clamp measurement that this mechanism inactivates the voltage-dependent potassium current and simultaneously generates photo-activated CS molecule induced (PACS) current owing to the loss of the cell membrane capacitance. Potassium 109-118 citrate synthase Rattus norvegicus 172-174 32449816-1 2020 It was anticipated that the potassium reagent RK (R = CH(SiMe3)2 or N(SiMe3)2) reacts with the low-valent Al(I) complex (DIPPBDI)Al (DIPPBDI = HC[C(Me)N(DIPP)]2, DIPP = 2,6-iPr-phenyl) to the anionic Al complex [(DIPPBDI)AlR]-K+. Potassium 28-37 nudix hydrolase 4 Homo sapiens 162-170 32912155-8 2020 The selection pressure estimation (Ka/Ks ratios) of genes in the Chrysosplenium species showed that matK and ycf2 were subjected to positive selection. Potassium 38-40 megakaryocyte-associated tyrosine kinase Homo sapiens 100-104 32506135-11 2020 CONCLUSIONS: Potassium supplementation led to a decrease in FGF23, which was accompanied by increase in plasma phosphate and decreased calcium excretion. Potassium 13-22 fibroblast growth factor 23 Homo sapiens 60-65 32506135-13 2020 Our results indicate distinct effects of potassium and sodium intake on bone mineral parameters, including FGF23. Potassium 41-50 fibroblast growth factor 23 Homo sapiens 107-112 32541000-0 2020 Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Potassium 97-106 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 0-6 32541000-0 2020 Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Potassium 97-106 plakophilin 4 Homo sapiens 36-40 32541000-0 2020 Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Potassium 97-106 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 63-69 32541000-3 2020 Understanding the molecular mechanisms that govern the regulation of inward rectifier potassium currents by Kir2.1 in both normal and disease contexts should help uncover novel targets for therapeutic intervention in ATS1 and other Kir2.1-associated channelopathies. Potassium 86-95 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 108-114 32541000-3 2020 Understanding the molecular mechanisms that govern the regulation of inward rectifier potassium currents by Kir2.1 in both normal and disease contexts should help uncover novel targets for therapeutic intervention in ATS1 and other Kir2.1-associated channelopathies. Potassium 86-95 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 232-238 32541000-8 2020 Finally, using patch-clamp analysis, we validate the functional relevance of PKP4, one of our top BioID interactors, to the modulation of Kir2.1-controlled inward rectifier potassium currents.Our results validate the power of our BioID approach in identifying functionally relevant Kir2.1interactors and underline the value of our Kir2.1 interactome as a repository for numerous novel biological hypotheseson Kir2.1 and Kir2.1-associated diseases. Potassium 173-182 plakophilin 4 Homo sapiens 77-81 32541000-8 2020 Finally, using patch-clamp analysis, we validate the functional relevance of PKP4, one of our top BioID interactors, to the modulation of Kir2.1-controlled inward rectifier potassium currents.Our results validate the power of our BioID approach in identifying functionally relevant Kir2.1interactors and underline the value of our Kir2.1 interactome as a repository for numerous novel biological hypotheseson Kir2.1 and Kir2.1-associated diseases. Potassium 173-182 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 138-144 32353862-8 2020 Ex vivo electrophysiological recordings show that nesfatin-1 hyperpolarizes dopamine, but not GABA, neurons of the VTA by inducing an outward potassium current. Potassium 142-151 nucleobindin 2 Homo sapiens 50-60 32835124-7 2020 Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Potassium 119-128 furin, paired basic amino acid cleaving enzyme Homo sapiens 14-19 32867854-14 2020 In addition, substitution of the two amino acids (KS) from nsp1 of SARS-CoV was previously reported to revert loss of interferon-alpha expression. Potassium 50-52 SH2 domain containing 3A Homo sapiens 59-63 32716363-5 2020 beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation. Potassium 67-76 NLR family pyrin domain containing 3 Homo sapiens 34-39 32861249-2 2020 Insulin sensitivity and metabolic acidosis are associated with muscle wasting and may be improved with potassium intake. Potassium 103-112 insulin Homo sapiens 0-7 32923723-9 2020 MMP-8 correlated inversely with pyridoxine (r = -0.321, P = 0.002) and potassium (r = -0.220, P = 0.033). Potassium 71-80 matrix metallopeptidase 8 Homo sapiens 0-5 32702990-3 2020 To better understand Kir channel activation, we target multiple mutants of the Kir channel KirBac1.1 via solid state Nuclear Magnetic Resonance (SSNMR) spectroscopy, potassium efflux assays, and Forster-resonance-energy-transfer (FRET) measurements. Potassium 166-175 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 79-82 32641496-1 2020 Two-pore domain potassium channels (K2P) are the major determinants of the background potassium conductance. Potassium 16-25 keratin 76 Homo sapiens 36-39 32641496-4 2020 The K2P channel subunits TRESK and TREK-2 provide the predominant background potassium current in the primary sensory neurons of the dorsal root and trigeminal ganglia. Potassium 77-86 keratin 76 Homo sapiens 4-7 32641496-4 2020 The K2P channel subunits TRESK and TREK-2 provide the predominant background potassium current in the primary sensory neurons of the dorsal root and trigeminal ganglia. Potassium 77-86 potassium two pore domain channel subfamily K member 18 Homo sapiens 25-30 32641496-4 2020 The K2P channel subunits TRESK and TREK-2 provide the predominant background potassium current in the primary sensory neurons of the dorsal root and trigeminal ganglia. Potassium 77-86 potassium two pore domain channel subfamily K member 10 Homo sapiens 35-41 32847923-2 2020 In the emergency room (ER), interventions aim to protect patients from the immediate dangers of elevated serum potassium by redistributing potassium ions from the bloodstream into the cells via intravenous insulin or nebulised beta2-agonists. Potassium 111-120 insulin Homo sapiens 206-213 32847923-2 2020 In the emergency room (ER), interventions aim to protect patients from the immediate dangers of elevated serum potassium by redistributing potassium ions from the bloodstream into the cells via intravenous insulin or nebulised beta2-agonists. Potassium 111-120 ATPase H+ transporting V0 subunit a2 Homo sapiens 227-232 32634531-5 2020 These features were mimicked by pharmacologically blocking the fast-inactivating A-type potassium current and matched well with the higher concentrations of Kv4.2 and Kv4.3 and the lower concentrations of BK and Kv1.2 channels detected by Western blotting. Potassium 88-97 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 157-162 32634531-5 2020 These features were mimicked by pharmacologically blocking the fast-inactivating A-type potassium current and matched well with the higher concentrations of Kv4.2 and Kv4.3 and the lower concentrations of BK and Kv1.2 channels detected by Western blotting. Potassium 88-97 potassium voltage-gated channel subfamily D member 3 Rattus norvegicus 167-172 32611790-2 2020 The H+/ K+-ATPase (HKA), which is comprised of the HKalpha1 (gene: atp4a) and HKbeta (gene: atp4b) subunits, has an established role in potassium and acid-base regulation in mammals and is well known for its role in gastric acidification. Potassium 136-145 potassium-transporting ATPase alpha chain 1 Oreochromis niloticus 67-72 32611790-2 2020 The H+/ K+-ATPase (HKA), which is comprised of the HKalpha1 (gene: atp4a) and HKbeta (gene: atp4b) subunits, has an established role in potassium and acid-base regulation in mammals and is well known for its role in gastric acidification. Potassium 136-145 potassium-transporting ATPase subunit beta Oreochromis niloticus 92-97 32903427-3 2020 While activation of the sodium-potassium-ATPase (NKA) in response to an elevation of extracellular K+ may decrease intracellular Na+, the cotransport of transmitters, such as glutamate, together with Na+ results in an increase in astrocytic Na+. Potassium 31-40 tachykinin precursor 1 Homo sapiens 49-52 32789612-4 2020 RECENT FINDINGS: Although the distal convoluted tubule (DCT) is a short part of the nephron that reabsorbs salt, via the sodium-chloride cotransporter (NCC), it is highly sensitive to changes in plasma potassium concentration. Potassium 202-211 solute carrier family 12 member 3 Homo sapiens 152-155 32789612-7 2020 High-potassium diet targets NCC in the DCT, resulting in natriuresis and fluid volume reduction, which are protective from hypertension and other cardiovascular problems. Potassium 5-14 solute carrier family 12 member 3 Homo sapiens 28-31 32590038-2 2020 Inwardly rectifying potassium (Kir) channels, and specifically KIR4.1, have a predominant role in K+ homeostasis and their involvement in neuronal excitability control have been hypothesized. Potassium 20-29 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 63-69 31671245-5 2020 Indeed, AMPK activators inhibit endothelium-dependent hyperpolarization (EDH) type relaxations in superior mesenteric arteries, partly by inhibiting endothelial calcium-activated potassium channels signalling. Potassium 179-188 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 8-12 32856786-6 2020 A TBDMS-beta-CD derivative with a p-tolyl substituent has a remarkable chiral selectivity for the (S)-1-(1-naphthyl)ethylamine over the corresponding (R)-isomer (KS /KR =4.1+-0.5), whereas a TBDMS-beta-CD derivative with a 2-picolyl substituent shows the inverse chiral selectivity (KR /KS =8.7+-0.6). Potassium 162-164 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 8-15 32856786-6 2020 A TBDMS-beta-CD derivative with a p-tolyl substituent has a remarkable chiral selectivity for the (S)-1-(1-naphthyl)ethylamine over the corresponding (R)-isomer (KS /KR =4.1+-0.5), whereas a TBDMS-beta-CD derivative with a 2-picolyl substituent shows the inverse chiral selectivity (KR /KS =8.7+-0.6). Potassium 162-164 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 197-204 32856786-6 2020 A TBDMS-beta-CD derivative with a p-tolyl substituent has a remarkable chiral selectivity for the (S)-1-(1-naphthyl)ethylamine over the corresponding (R)-isomer (KS /KR =4.1+-0.5), whereas a TBDMS-beta-CD derivative with a 2-picolyl substituent shows the inverse chiral selectivity (KR /KS =8.7+-0.6). Potassium 287-289 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 8-15 32856786-6 2020 A TBDMS-beta-CD derivative with a p-tolyl substituent has a remarkable chiral selectivity for the (S)-1-(1-naphthyl)ethylamine over the corresponding (R)-isomer (KS /KR =4.1+-0.5), whereas a TBDMS-beta-CD derivative with a 2-picolyl substituent shows the inverse chiral selectivity (KR /KS =8.7+-0.6). Potassium 287-289 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 197-204 31919958-0 2020 Cardiovascular risk associated with serum potassium in the context of mineralocorticoid receptor antagonist use in patients with heart failure and left ventricular dysfunction. Potassium 42-51 nuclear receptor subfamily 3 group C member 2 Homo sapiens 70-96 32742012-13 2020 Similar decreases in serum potassium were noted following IV regular insulin administration. Potassium 27-36 insulin Homo sapiens 69-76 31496375-1 2020 Study of seven new guanidiniocarbonylpyrrole (GCP) - fluorophore conjugates interactions with dipeptidyl peptidase III (DPP III) showed that all compounds bind strongly (Ks microM) to enzyme active site, but with very different fluorimetric response (varying from quenching to strong increase), dependent on the fluorophore type and intramolecular pre-organisation of molecule. Potassium 170-172 dipeptidyl peptidase 3 Homo sapiens 94-118 31496375-1 2020 Study of seven new guanidiniocarbonylpyrrole (GCP) - fluorophore conjugates interactions with dipeptidyl peptidase III (DPP III) showed that all compounds bind strongly (Ks microM) to enzyme active site, but with very different fluorimetric response (varying from quenching to strong increase), dependent on the fluorophore type and intramolecular pre-organisation of molecule. Potassium 170-172 dipeptidyl peptidase 3 Homo sapiens 120-127 33214341-0 2020 Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice. Potassium 0-9 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Mus musculus 48-53 33214341-3 2020 Nckx3, a potassium-dependent Na+/Ca2+ exchanger, is most abundant in the brain and has a critical role in the transport of intracellular calcium across the cell membrane. Potassium 9-18 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Mus musculus 0-5 33040821-16 2020 Low-dose insulin combined with electrolyte supplementation is effective in the treatment of DKA in children, which can effectively control blood sugar, sodium, potassium level, and inflammatory factor concentration. Potassium 160-169 insulin Homo sapiens 9-16 32407847-8 2020 KEY FINDINGS: The results showed that the TR and/or HES treatment significantly suppressed CCl4 induced rise of urea, uric acid, potassium, and follicle-stimulating hormone levels. Potassium 129-138 C-C motif chemokine ligand 4 Rattus norvegicus 91-95 32727346-5 2020 RESULTS: On slice electrophysiology, LC-NE neurons of Ndntm1ky mice with necdin deficiency showed significantly decreased spontaneous activities and impaired excitability, which was mediated by enhanced A-type voltage-dependent potassium currents. Potassium 228-237 necdin, MAGE family member Mus musculus 73-79 32720790-6 2021 Besides, the expression levels of potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1) and microRNA-340-5p (miR-340-5p) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Potassium 34-43 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 106-114 32702863-19 2020 Moreover, the patients with only 1 SLC12A3 mutant allele should pay regular attention to blood potassium and glucose levels. Potassium 95-104 solute carrier family 12 member 3 Homo sapiens 35-42 31732108-7 2020 Further supporting the involvement of potassium currents, we observed an overexpression of KCNC1 and KCNC2 in hippocampal neurons derived from lithium responders. Potassium 38-47 potassium voltage-gated channel subfamily C member 1 Homo sapiens 91-96 31732108-7 2020 Further supporting the involvement of potassium currents, we observed an overexpression of KCNC1 and KCNC2 in hippocampal neurons derived from lithium responders. Potassium 38-47 potassium voltage-gated channel subfamily C member 2 Homo sapiens 101-106 32818118-3 2020 Up to 35% of healthy individuals below 25 years of age, trained athletes, and those with a rare form of the familial syndrome with potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) mutation may have asymptomatic sinus bradycardia without any heart diseases. Potassium 131-140 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Homo sapiens 148-209 32818118-3 2020 Up to 35% of healthy individuals below 25 years of age, trained athletes, and those with a rare form of the familial syndrome with potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) mutation may have asymptomatic sinus bradycardia without any heart diseases. Potassium 131-140 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Homo sapiens 211-215 32645929-4 2020 Pulmonary sodium-potassium-chloride co-transporter 1 (NKCC1) regulates the net influx of ions and water into alveolar cells. Potassium 17-26 solute carrier family 12 member 2 Homo sapiens 54-59 32576659-5 2020 Using a panel of reporter assays in reconstituted HEK293T/17 cells, we found that GPR139 functions via the Gq/11 pathway and thereby distinctly regulates cellular effector systems, including stimulation of cAMP production and inhibition of G protein inward rectifying potassium (GIRK) channels. Potassium 268-277 G protein-coupled receptor 139 Homo sapiens 82-88 32714200-11 2020 A high-potassium diet significantly increased BK protein abundance and SPAK phosphorylation levels, while reducing ERK1/2 phosphorylation levels. Potassium 7-16 serine/threonine kinase 39 Mus musculus 71-75 32714200-11 2020 A high-potassium diet significantly increased BK protein abundance and SPAK phosphorylation levels, while reducing ERK1/2 phosphorylation levels. Potassium 7-16 mitogen-activated protein kinase 3 Mus musculus 115-121 32353421-0 2020 NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. Potassium 74-83 NIMA (never in mitosis gene a)-related expressed kinase 7 Mus musculus 0-4 32353421-0 2020 NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. Potassium 74-83 NLR family, pyrin domain containing 3 Mus musculus 41-46 32353421-7 2020 Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux. Potassium 142-151 NIMA (never in mitosis gene a)-related expressed kinase 7 Mus musculus 55-59 32353421-7 2020 Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux. Potassium 142-151 NLR family, pyrin domain containing 3 Mus musculus 64-69 32353421-7 2020 Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux. Potassium 142-151 NLR family, pyrin domain containing 3 Mus musculus 109-114 31907393-9 2020 The lysine residues (K51 and K68) are essential for ubiquitination and proteasomal degradation of ERRalpha by CA. Potassium 29-32 estrogen related receptor alpha Homo sapiens 98-106 31598634-10 2020 CONCLUSION: We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. Potassium 187-196 ETS transcription factor ERG Homo sapiens 182-186 32068308-1 2020 Kir4.1, a glial-specific inwardly rectifying potassium channel, is implicated in astrocytic maintenance of K+ homeostasis. Potassium 45-54 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 0-6 31898359-8 2020 The expression of cardiomyocytes genes MYH6, TNNT2, DES together with ion channels genes of the heart (sodium, calcium, and potassium) decreased in p31/33 induced AF-MSCs. Potassium 124-133 ATPase H+ transporting V1 subunit E1 Homo sapiens 148-151 32360664-8 2020 Other cell-type specific processes altered in SOD1 mutant brainstem include those from motor neurons (axon regeneration, voltage-gated sodium and potassium channels underlying excitability, potassium ion transport), trigeminal sensory neurons (detection of temperature stimulus involved in sensory perception), and cellular response to toxic substances (uncharacterized cell populations). Potassium 146-155 superoxide dismutase 1, soluble Mus musculus 46-50 32703555-0 2020 Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol. Potassium 54-63 ETS transcription factor ERG Homo sapiens 48-52 32703555-3 2020 Their hypothesis was that soestalol, but not the acid metabolite, would inhibit the hERG potassium current. Potassium 89-98 ETS transcription factor ERG Homo sapiens 84-88 32045575-7 2020 Since DC shift is commonly associated to a rise in extracellular potassium, potassium homeostasis regulated by Kir4.1 channels in astrocytes may play an key role at seizure onset. Potassium 65-74 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 111-117 32045575-7 2020 Since DC shift is commonly associated to a rise in extracellular potassium, potassium homeostasis regulated by Kir4.1 channels in astrocytes may play an key role at seizure onset. Potassium 76-85 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 111-117 32937450-1 2020 Kv2.1 channels mediate cell death-enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Potassium 61-70 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 0-5 31865509-0 2020 The topology of plastid inner envelope potassium cation efflux antiporter KEA1 provides new insights into its regulatory features. Potassium 39-48 K+ efflux antiporter 1 Arabidopsis thaliana 74-78 32209376-3 2020 In this study, the effects of KS on AKR1C3 inhibition and anti-proliferative activities were investigated in the hormone-dependent MCF-7 breast cancer cells. Potassium 30-32 aldo-keto reductase family 1 member C3 Homo sapiens 36-42 32209376-4 2020 We identified that KS arrested the enzymatic conversion of estrone to 17-beta estradiol, by inhibiting AKR1C3 in intact MCF-7 cells. Potassium 19-21 aldo-keto reductase family 1 member C3 Homo sapiens 103-109 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 78-80 aldo-keto reductase family 1 member C3 Homo sapiens 84-90 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 78-80 aldo-keto reductase family 1 member C3 Homo sapiens 139-145 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 78-80 aldo-keto reductase family 1 member C3 Homo sapiens 139-145 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 105-107 aldo-keto reductase family 1 member C3 Homo sapiens 84-90 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 105-107 aldo-keto reductase family 1 member C3 Homo sapiens 139-145 32209376-8 2020 Molecular docking studies performed to understand the inhibition mechanism of KS on AKR1C3 revealed that KS occupied the binding region of AKR1C3 with almost similar orientation as indomethacin (IM), thereby acting as an antagonistic agent for AKR1C3. Potassium 105-107 aldo-keto reductase family 1 member C3 Homo sapiens 139-145 32209376-9 2020 Based on the results it is identified that KS induces inhibition of AKR1C3 and cell death in MCF-7 cells. Potassium 43-45 aldo-keto reductase family 1 member C3 Homo sapiens 68-74 32209376-10 2020 These results indicate that KS can be used as a molecular scaffold for further development of novel small-molecules with better specificity towards AKR1C3. Potassium 28-30 aldo-keto reductase family 1 member C3 Homo sapiens 148-154 32286583-0 2020 A mitochondria-targeting NIR fluorescent potassium ion sensor: real-time investigation of the mitochondrial K+ regulation of apoptosis in situ. Potassium 41-50 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 25-28 32603346-0 2020 Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia. Potassium 59-68 solute carrier family 8 member A1 Homo sapiens 0-26 32374168-6 2020 Overall, the observed CBD suppressive effect on NLRP3 inflammasome activation in THP-1 monocytes was associated with decreased potassium efflux, as well as in silico prediction of P2X7 receptor binding. Potassium 127-136 NLR family pyrin domain containing 3 Homo sapiens 48-53 32374168-6 2020 Overall, the observed CBD suppressive effect on NLRP3 inflammasome activation in THP-1 monocytes was associated with decreased potassium efflux, as well as in silico prediction of P2X7 receptor binding. Potassium 127-136 GLI family zinc finger 2 Homo sapiens 81-86 32572427-4 2020 Serum 5-HT levels were detected with ELISA, and potassium/sodium hyperpolarization activated cyclic nucleotide-gated channel 2 (HCN2) and tryptophan hydroxylase 1 (TPH1) expression levels in colon epithelium of offspring were detected by Western blot and RT-qPCR. Potassium 48-57 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Mus musculus 128-132 32572427-4 2020 Serum 5-HT levels were detected with ELISA, and potassium/sodium hyperpolarization activated cyclic nucleotide-gated channel 2 (HCN2) and tryptophan hydroxylase 1 (TPH1) expression levels in colon epithelium of offspring were detected by Western blot and RT-qPCR. Potassium 48-57 tryptophan hydroxylase 1 Mus musculus 164-168 32656189-8 2020 Furthermore, ion channel expression was altered in terms of potassium (Kir2.1 overexpression) and calcium handling (dihydropyridine receptor overexpression). Potassium 60-69 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 71-77 32625100-0 2020 Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2. Potassium 8-17 angiotensin I converting enzyme Rattus norvegicus 32-63 32625100-0 2020 Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2. Potassium 8-17 renin Rattus norvegicus 65-70 32625100-0 2020 Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2. Potassium 8-17 angiotensin I converting enzyme 2 Rattus norvegicus 76-107 32625100-4 2020 With the hypothesis that dietary potassium reduces renal vasoconstrictor components of the renin-angiotensin system in the long-term, we studied the effect of high potassium diet on angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2. Potassium 33-42 renin Rattus norvegicus 91-96 32625100-10 2020 Results: High potassium diet (4 weeks) reduced the levels of renin, angiotensin-I converting enzyme, and angiotensin converting enzyme 2. Potassium 14-23 renin Rattus norvegicus 61-66 32625100-10 2020 Results: High potassium diet (4 weeks) reduced the levels of renin, angiotensin-I converting enzyme, and angiotensin converting enzyme 2. Potassium 14-23 angiotensin I converting enzyme Rattus norvegicus 68-99 32625100-10 2020 Results: High potassium diet (4 weeks) reduced the levels of renin, angiotensin-I converting enzyme, and angiotensin converting enzyme 2. Potassium 14-23 angiotensin I converting enzyme 2 Rattus norvegicus 105-136 32625100-13 2020 High potassium intake decreased angiotensin converting enzyme 2 gene expression and protein levels (P < 0.01).No morphological abnormalities were observed in renal tissue during high potassium diet.The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium. Potassium 5-14 angiotensin I converting enzyme 2 Rattus norvegicus 32-63 32625100-13 2020 High potassium intake decreased angiotensin converting enzyme 2 gene expression and protein levels (P < 0.01).No morphological abnormalities were observed in renal tissue during high potassium diet.The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium. Potassium 5-14 angiotensin I converting enzyme Rattus norvegicus 224-255 32625100-13 2020 High potassium intake decreased angiotensin converting enzyme 2 gene expression and protein levels (P < 0.01).No morphological abnormalities were observed in renal tissue during high potassium diet.The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium. Potassium 5-14 renin Rattus norvegicus 257-262 32625100-13 2020 High potassium intake decreased angiotensin converting enzyme 2 gene expression and protein levels (P < 0.01).No morphological abnormalities were observed in renal tissue during high potassium diet.The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium. Potassium 5-14 angiotensin I converting enzyme 2 Rattus norvegicus 268-299 32338831-1 2020 The slow delayed rectifier potassium current (I Ks ) is formed by the KCNQ1 (K v 7.1) channel, an ion channel bearing four alpha-subunits and modulating KCNE1 beta-subunits. Potassium 27-36 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 70-75 32338831-1 2020 The slow delayed rectifier potassium current (I Ks ) is formed by the KCNQ1 (K v 7.1) channel, an ion channel bearing four alpha-subunits and modulating KCNE1 beta-subunits. Potassium 48-50 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 70-75 32552741-12 2020 Blocking potassium efflux or inhibiting caspase-1 prevents 25-HC-potentiated IL-1beta release in apoE4-expressing microglia, indicating the involvement of caspase-1 inflammasome activity. Potassium 9-18 interleukin 1 alpha Mus musculus 77-85 32359429-4 2020 Analysis of the naked mole-rat genome revealed, uniquely among mammals, a histidine point variation in the neuronal potassium-chloride cotransporter 2 (KCC2). Potassium 116-125 solute carrier family 12 member 5 Homo sapiens 152-156 32514747-4 2020 Subsequent analysis suggested that SAPK2 considerably influences the nitrogen, phosphorus, and potassium contents of rice grains. Potassium 95-104 serine/threonine-protein kinase SAPK2 Oryza sativa Japonica Group 35-40 32490811-2 2020 We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing phenotype, due to different low-voltage-activated potassium currents. Potassium 217-226 cholecystokinin Rattus norvegicus 34-37 32582195-6 2020 A mechanistic study revealed that S. sonnei induced IL-1beta production through P2X7 receptor-mediated potassium efflux, reactive oxygen species generation, lysosomal acidification, and mitochondrial damage. Potassium 103-112 interleukin 1 alpha Homo sapiens 52-60 32488011-2 2020 We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Potassium 101-110 fragile X messenger ribonucleoprotein 1 Mus musculus 17-21 32488011-2 2020 We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Potassium 101-110 caveolin 3 Mus musculus 39-43 32488011-2 2020 We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Potassium 101-110 potassium voltage gated channel, Shaw-related subfamily, member 1 Mus musculus 44-47 32338037-7 2020 In addition, male KS-BMAL1 KO had less sodium retention compared to CNTL in response to a potassium-restricted diet (15% less following 5 days of treatment). Potassium 90-99 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 21-26 32008360-1 2020 The potassium voltage-gated channel subfamily J member 11 gene (KCNJ11) is involved in the insulin secretion pathway. Potassium 4-13 potassium inwardly rectifying channel subfamily J member 11 Gallus gallus 64-70 31935579-3 2020 Aim of this work is to assess the effect of four drugs blocking the human ether-a-go-go-related gene (hERG) potassium channel, alone or in combination with other ionic channel blocks, on SHVR, as estimated by the V-index on short triplicate 10 s ECG. Potassium 108-117 ETS transcription factor ERG Homo sapiens 102-106 32352602-8 2020 As shown by immunostaining of endothelial makers, renal vascular densities were decreased accompanied by increased HIF-1alpha and erythropoietin levels in the kidneys of KS-tg/OVE mice. Potassium 170-172 hypoxia inducible factor 1, alpha subunit Mus musculus 115-125 32352602-8 2020 As shown by immunostaining of endothelial makers, renal vascular densities were decreased accompanied by increased HIF-1alpha and erythropoietin levels in the kidneys of KS-tg/OVE mice. Potassium 170-172 erythropoietin Mus musculus 130-144 32155353-5 2020 Aquaporin-4 (AQP4) is implicated in a number of physiopathological processes, particularly in the development of brain edema, and other functions such as the regulation of extracellular space volume, potassium buffering, waste clearance, and calcium signaling. Potassium 200-209 aquaporin 4 Bos taurus 13-17 32295826-7 2020 Double-knockout mice lacking both Kir4.1/Kir5.1 and Nedd4-2 in the kidney exhibited increased expression of the epithelial sodium channel alpha-subunit, largely abolished basolateral potassium ion conductance (to a degree similar to that of kidney-specific Kir4.1 knockout mice), and depolarization of the DCT membrane. Potassium 183-192 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 34-40 32295826-7 2020 Double-knockout mice lacking both Kir4.1/Kir5.1 and Nedd4-2 in the kidney exhibited increased expression of the epithelial sodium channel alpha-subunit, largely abolished basolateral potassium ion conductance (to a degree similar to that of kidney-specific Kir4.1 knockout mice), and depolarization of the DCT membrane. Potassium 183-192 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 41-47 32295826-7 2020 Double-knockout mice lacking both Kir4.1/Kir5.1 and Nedd4-2 in the kidney exhibited increased expression of the epithelial sodium channel alpha-subunit, largely abolished basolateral potassium ion conductance (to a degree similar to that of kidney-specific Kir4.1 knockout mice), and depolarization of the DCT membrane. Potassium 183-192 neural precursor cell expressed, developmentally down-regulated gene 4-like Mus musculus 52-59 31792968-0 2020 Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity. Potassium 64-73 potassium voltage-gated channel interacting protein 4 Rattus norvegicus 40-46 31792968-7 2020 Additional luciferase assays and western blots validated kcnip4, a Kv4-mediated A-type potassium current (IA ) regulator, as a direct target of miR-3068-3p. Potassium 87-96 potassium voltage-gated channel interacting protein 4 Rattus norvegicus 57-63 30189765-9 2020 CONCLUSIONS: Conventional dose insulin may be more effective than reduced dose regular insulin at baseline serum potassium levels >6 mmol/L in the treatment of hyperkalemia. Potassium 113-122 insulin Homo sapiens 31-38 30189765-9 2020 CONCLUSIONS: Conventional dose insulin may be more effective than reduced dose regular insulin at baseline serum potassium levels >6 mmol/L in the treatment of hyperkalemia. Potassium 113-122 insulin Homo sapiens 87-94 30189765-10 2020 Frequent monitoring of serum potassium and glucose after administration of insulin is necessary to confirm adequate response and avoidance of hypoglycemia. Potassium 29-38 insulin Homo sapiens 75-82 32525548-18 2020 Conclusions and Relevance: The correction of hypokalemia is challenging because of continuous renal potassium loss resulting from the degradation of angiotensin-converting enzyme 2. Potassium 100-109 angiotensin converting enzyme 2 Homo sapiens 149-180 32299681-0 2020 Collecting system-specific deletion of Kcnj10 predisposes for thiazide- and low-potassium diet-induced hypokalemia. Potassium 80-89 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 39-45 32299681-6 2020 Collecting system-Kcnj10-knockout mice responded normally to standard and high potassium diet. Potassium 79-88 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 18-24 32299681-11 2020 Thus, KCNJ10 in the collecting system contributes to the renal control of potassium homeostasis by regulating ENaC and ROMK. Potassium 74-83 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 6-12 32299681-11 2020 Thus, KCNJ10 in the collecting system contributes to the renal control of potassium homeostasis by regulating ENaC and ROMK. Potassium 74-83 sodium channel, nonvoltage-gated 1 alpha Mus musculus 110-114 32299681-11 2020 Thus, KCNJ10 in the collecting system contributes to the renal control of potassium homeostasis by regulating ENaC and ROMK. Potassium 74-83 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 119-123 32299681-12 2020 Hence, impaired KCNJ10 function in the collecting system predisposes for thiazide and low potassium diet-induced hypokalemia and likely contributes to the pathophysiology of renal potassium loss in EAST/SeSAME syndrome. Potassium 90-99 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 16-22 32299681-12 2020 Hence, impaired KCNJ10 function in the collecting system predisposes for thiazide and low potassium diet-induced hypokalemia and likely contributes to the pathophysiology of renal potassium loss in EAST/SeSAME syndrome. Potassium 180-189 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 16-22 32167513-4 2020 The FeCo@C@MoS2 electrode displays high reversible capacities of 380 mA h g-1 and 147 mA h g-1 at 500 mA g-1 for sodium and potassium storage, respectively. Potassium 124-133 proline rich protein BstNI subfamily 3 Homo sapiens 74-108 32374315-4 2020 The obtained VN/CNF composite anode exhibited excellent half/full sodium and potassium storage performance. Potassium 77-86 NPHS1 adhesion molecule, nephrin Homo sapiens 16-19 32509580-6 2020 The blockade of epidermal growth factor receptor (EGFR) by anti-EGFR antibodies can result in clinically significant magnesium and potassium losses. Potassium 131-140 epidermal growth factor receptor Homo sapiens 16-48 32509580-6 2020 The blockade of epidermal growth factor receptor (EGFR) by anti-EGFR antibodies can result in clinically significant magnesium and potassium losses. Potassium 131-140 epidermal growth factor receptor Homo sapiens 50-54 32509580-6 2020 The blockade of epidermal growth factor receptor (EGFR) by anti-EGFR antibodies can result in clinically significant magnesium and potassium losses. Potassium 131-140 epidermal growth factor receptor Homo sapiens 64-68 32499707-1 2020 Inwardly rectifying potassium (KIR) channels play important roles in controlling cellular excitability and K+ ion homeostasis. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 31-34 32499717-8 2020 TREK-1 and Piezo1 have been selected, as they are widely expressed in the body, including cardiac tissue, and they are "canonical representatives" for the potassium selective and the cation non-selective SAC families, respectively. Potassium 155-164 potassium two pore domain channel subfamily K member 2 Homo sapiens 0-6 32499717-8 2020 TREK-1 and Piezo1 have been selected, as they are widely expressed in the body, including cardiac tissue, and they are "canonical representatives" for the potassium selective and the cation non-selective SAC families, respectively. Potassium 155-164 piezo type mechanosensitive ion channel component 1 Homo sapiens 11-17 32088442-3 2020 Result indicated that potassium was successfully doped into the g-C3N4 framework via direct heating the mixture of melamine and potassium iodide at 520 C, which increases the BET surface area, broadens the visible light response region, and elevates the separation efficiency of electron-hole pairs. Potassium 22-31 delta/notch like EGF repeat containing Homo sapiens 176-179 32398094-3 2020 p13 is mainly localized in the inner membrane of the mitochondria, where it induces potassium (K+) influx and reactive oxygen species (ROS) production, which can trigger either proliferation or apoptosis, depending on the ROS setpoint of the cell. Potassium 84-93 H3 histone pseudogene 6 Homo sapiens 0-3 32392309-2 2020 Retinoschisin specifically interacts with the retinal sodium-potassium adenosine triphosphatase (Na/K-ATPase), a transmembrane ion pump. Potassium 61-70 retinoschisis (X-linked, juvenile) 1 (human) Mus musculus 0-13 32053194-0 2020 The calcineurin beta-like interacting protein kinase CIPK25 regulates potassium homeostasis under low oxygen in Arabidopsis. Potassium 70-79 CBL-interacting protein kinase 25 Arabidopsis thaliana 53-59 32053194-3 2020 A cipk25 mutant exhibited higher sensitivity to anoxia in conditions of potassium limitation, suggesting that this kinase is involved in the regulation of potassium uptake. Potassium 72-81 CBL-interacting protein kinase 25 Arabidopsis thaliana 2-8 32053194-3 2020 A cipk25 mutant exhibited higher sensitivity to anoxia in conditions of potassium limitation, suggesting that this kinase is involved in the regulation of potassium uptake. Potassium 155-164 CBL-interacting protein kinase 25 Arabidopsis thaliana 2-8 32053194-4 2020 Interestingly, we found that CIPK25 interacts with AKT1, the major inward rectifying potassium channel in Arabidopsis. Potassium 85-94 CBL-interacting protein kinase 25 Arabidopsis thaliana 29-35 32053194-4 2020 Interestingly, we found that CIPK25 interacts with AKT1, the major inward rectifying potassium channel in Arabidopsis. Potassium 85-94 K+ transporter 1 Arabidopsis thaliana 51-55 32053194-5 2020 Under anoxic conditions, cipk25 mutant seedlings were unable to maintain potassium concentrations at wild-type levels, suggesting that CIPK25 likely plays a role in modulating potassium homeostasis under low-oxygen conditions. Potassium 176-185 CBL-interacting protein kinase 25 Arabidopsis thaliana 25-31 32053194-5 2020 Under anoxic conditions, cipk25 mutant seedlings were unable to maintain potassium concentrations at wild-type levels, suggesting that CIPK25 likely plays a role in modulating potassium homeostasis under low-oxygen conditions. Potassium 176-185 CBL-interacting protein kinase 25 Arabidopsis thaliana 135-141 32376987-3 2020 Herein, we found that a guanine rich tract, capable of forming intramolecular G-quadruplex in the presence of potassium ions, in the promoter region of human TMPRSS2 gene was quite important for gene transcriptional activity, hence affecting its function. Potassium 110-119 transmembrane serine protease 2 Homo sapiens 158-165 31754927-0 2020 The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells. Potassium 4-13 potassium voltage-gated channel subfamily E regulatory subunit 3 Homo sapiens 22-27 31754927-0 2020 The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells. Potassium 4-13 vascular endothelial growth factor A Homo sapiens 33-38 31825788-0 2020 The membrane protein KCNQ1 potassium ion channel: Functional diversity and current structural insights. Potassium 27-36 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 21-26 32004973-7 2020 The activation of the P2X7R can open the ion channels on the tumor cell membrane (sodium ion, calcium ion influx and potassium ion outflow), trigger rearrangement of the cytoskeleton and changes in membrane fluidity, allow small molecule substances to enter the cell, activate enzymes and kinases in related signaling pathways in cells (such as PKA, PKC, ERK1/2, AKT, and JNK), thereby affecting the development of tumor cells, and can also indirectly affect the growth, apoptosis and migration of tumor cells through tumor microenvironment. Potassium 117-126 purinergic receptor P2X 7 Homo sapiens 22-27 31900739-0 2020 Dietary potassium restriction attenuates urinary sodium wasting in the generalized form of pseudohypoaldosteronism type 1. Potassium 8-17 sodium channel epithelial 1 subunit gamma Homo sapiens 91-121 31900739-2 2020 In particular, the usefulness of dietary potassium restriction in PHA1 remains unclear with the absence of theoretical background to elucidate its utility. Potassium 41-50 sodium channel epithelial 1 subunit gamma Homo sapiens 66-70 31900739-3 2020 First, we demonstrated the effect of potassium restriction in a 13-month-old patient with ENaC gamma-subunit gene mutations via a retrospective chart review; reduction of daily dietary potassium intake from 40 to 20 mEq induced rapid restoration of volume depletion, as evidenced by weight gain, elevation of the serum sodium level from 133 to 141 mEq/L, decreased urinary sodium excretion, and normalized renin activity. Potassium 37-46 sodium channel epithelial 1 subunit gamma Homo sapiens 90-108 31900739-8 2020 Thus, potassium restriction causes NCC and pendrin to compensate for the non-functional ENaC in the collecting duct. Potassium 6-15 solute carrier family 26 member 4 Homo sapiens 43-50 31900739-9 2020 In conclusion, dietary potassium restriction is one of the indispensable treatments for generalized PHA1. Potassium 23-32 sodium channel epithelial 1 subunit gamma Homo sapiens 100-104 31781992-9 2020 Additionally, it was found that BnFAD3 is a transmembrane protein that can convert omega6 to omega3 fatty acids and may simultaneously act as a potassium ion channel in the ER. Potassium 144-153 omega-3 fatty acid desaturase, endoplasmic reticulum Brassica napus 32-38 31881264-1 2020 As one important member of the two-pore-domain potassium channel (K2P) family, potassium channel subfamily K member 3 (KCNK3) has been reported for thermogenesis regulation, energy homeostasis, membrane potential conduction, and pulmonary hypertension in mammals. Potassium 47-56 potassium channel subfamily K member 3 Oreochromis niloticus 119-124 31881264-1 2020 As one important member of the two-pore-domain potassium channel (K2P) family, potassium channel subfamily K member 3 (KCNK3) has been reported for thermogenesis regulation, energy homeostasis, membrane potential conduction, and pulmonary hypertension in mammals. Potassium 79-88 potassium channel subfamily K member 3 Oreochromis niloticus 119-124 32027066-2 2020 These genes encode the subunits of the beta-cell ATP sensitive potassium channel, a key component of the glucose-stimulated insulin secretion pathway. Potassium 63-72 insulin Homo sapiens 124-131 31856407-0 2020 Formate and potassium ions affect Escherichia coli proton ATPase activity at low pH during mixed carbon fermentation. Potassium 12-21 ATPase Escherichia coli 58-64 31856407-8 2020 Taken together, the data suggest that proton ATPase activity depends on externally added formate in the presence of potassium ions at low pH. Potassium 116-125 ATPase Escherichia coli 45-51 32037944-8 2020 For tactile stimulus, the following active ingredients showed large beneficial effects compared to fluoride with moderate certainty of evidence (SMD; 95% CI): potassium + stannous fluoride (SnF2) (3.05; 1.69-4.41), calcium sodium phosphosilicate (CSP) (2.14; 0.75-3.53), SnF2 (2.02; 1.06-2.99), potassium + hydroxyapatite (2.47; 0.3-4.64), strontium (1.43; 0.46-2.41), and potassium (1.23; 0.48-1.98). Potassium 159-168 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 190-194 31420581-9 2020 Intake of potassium was, however, negatively associated with SBP (P20-P30, P70-P80) in males, and also negatively associated with SBP (P10-P80) and DBP(P20-P50) in females. Potassium 10-19 coilin Homo sapiens 79-82 31420581-9 2020 Intake of potassium was, however, negatively associated with SBP (P20-P30, P70-P80) in males, and also negatively associated with SBP (P10-P80) and DBP(P20-P50) in females. Potassium 10-19 S100 calcium binding protein A10 Homo sapiens 135-138 31420581-9 2020 Intake of potassium was, however, negatively associated with SBP (P20-P30, P70-P80) in males, and also negatively associated with SBP (P10-P80) and DBP(P20-P50) in females. Potassium 10-19 coilin Homo sapiens 139-142 31420581-10 2020 Sodium to potassium ratio was positively associated with SBP (P10-P50, P80) and DBP (P70-P90) in males, and was positively associated with SBP(P10-P70, P90) in females. Potassium 10-19 S100 calcium binding protein A10 Homo sapiens 62-65 31420581-10 2020 Sodium to potassium ratio was positively associated with SBP (P10-P50, P80) and DBP (P70-P90) in males, and was positively associated with SBP(P10-P70, P90) in females. Potassium 10-19 coilin Homo sapiens 71-74 31420581-10 2020 Sodium to potassium ratio was positively associated with SBP (P10-P50, P80) and DBP (P70-P90) in males, and was positively associated with SBP(P10-P70, P90) in females. Potassium 10-19 coiled-coil domain containing 8 Homo sapiens 89-92 31420581-10 2020 Sodium to potassium ratio was positively associated with SBP (P10-P50, P80) and DBP (P70-P90) in males, and was positively associated with SBP(P10-P70, P90) in females. Potassium 10-19 S100 calcium binding protein A10 Homo sapiens 143-146 31420581-10 2020 Sodium to potassium ratio was positively associated with SBP (P10-P50, P80) and DBP (P70-P90) in males, and was positively associated with SBP(P10-P70, P90) in females. Potassium 10-19 coiled-coil domain containing 8 Homo sapiens 152-155 31901677-0 2020 Elucidation of interaction mechanism of hERG1 potassium channel with scorpion toxins BeKm-1 and BmTx3b. Potassium 46-55 potassium voltage-gated channel subfamily H member 2 Homo sapiens 40-45 32067254-3 2020 As activity-induced potassium transients are rapidly managed by astrocytic Kir4.1 and astrocyte-specific Na+ /K+ -ATPase, any neurotransmitter/neuromodulator that can regulate their function may have indirect influence on network activity. Potassium 20-29 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 75-81 32492001-9 2020 In conclusion, our results suggest that the ZmHAK1 regulation has an important role in the process of absorbing potassium ions, and possibly in the response of maize to abiotic stress. Potassium 112-121 Potassium transporter 1 Zea mays 44-50 32327288-1 2020 Nav1.4 channelopathies due to SCN4A mutations can present with episodic attacks of myotonia triggered by fluctuation in the potassium level (potassium-aggravated myotonia). Potassium 124-133 sodium voltage-gated channel alpha subunit 4 Homo sapiens 0-6 32327288-1 2020 Nav1.4 channelopathies due to SCN4A mutations can present with episodic attacks of myotonia triggered by fluctuation in the potassium level (potassium-aggravated myotonia). Potassium 124-133 sodium voltage-gated channel alpha subunit 4 Homo sapiens 30-35 32327288-1 2020 Nav1.4 channelopathies due to SCN4A mutations can present with episodic attacks of myotonia triggered by fluctuation in the potassium level (potassium-aggravated myotonia). Potassium 141-150 sodium voltage-gated channel alpha subunit 4 Homo sapiens 0-6 32327288-1 2020 Nav1.4 channelopathies due to SCN4A mutations can present with episodic attacks of myotonia triggered by fluctuation in the potassium level (potassium-aggravated myotonia). Potassium 141-150 sodium voltage-gated channel alpha subunit 4 Homo sapiens 30-35 32327288-2 2020 We report a case of potassium-aggravated myotonia due to Nav1.4-M1592V channelopathy with severe and long-lasting focal attacks of myotonia resembling dystonic posturing with diffuse muscle edema in the affected muscles in magnetic resonance imaging and almost constant presence of myotonic discharges in electromyography that can best be described as focal "status myotonicus". Potassium 20-29 sodium voltage-gated channel alpha subunit 4 Homo sapiens 57-63 32543130-4 2020 Results: The area under the ROC curve ( AUC) of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) was greater than that of the ratio of the upright PAC to the angiotensin II (AT-II) (AA2R), upright PRA, upright PAC, supine ARR, and lowest blood potassium ( P<0.05). Potassium 281-290 renin Homo sapiens 101-106 32297137-7 2020 To elucidate the role of potassium efflux as an upstream signal of NLRP3 inflammasome activation, equine PBMCs were treated with blockers of potassium efflux in the presence of NLRP3 triggers. Potassium 25-34 NLR family pyrin domain containing 3 Equus caballus 67-72 32408404-0 2020 Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2. Potassium 48-57 microRNA 137 Mus musculus 8-20 32408404-0 2020 Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2. Potassium 48-57 solute carrier family 12, member 5 Mus musculus 73-77 32408404-4 2020 Here we generated a forebrain-specific MIR137 knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. Potassium 147-156 microRNA 137 Mus musculus 103-110 32408404-6 2020 The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. Potassium 68-77 solute carrier family 12, member 5 Mus musculus 4-8 32408404-6 2020 The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. Potassium 68-77 microRNA 137 Mus musculus 81-88 32426734-9 2020 Conclusions: Patients treated for hyperkalemia with insulin doses less than 10 units had reduced frequency of hypoglycemia; however, potassium reduction post treatment was more modest in these patients. Potassium 133-142 insulin Homo sapiens 52-59 32233369-0 2020 Combined Experimental and Theoretical Studies on Electron-Transfer in Potassium Collisions with CCl4. Potassium 70-79 C-C motif chemokine ligand 4 Homo sapiens 96-100 32233369-2 2020 Comprehensive calculations on the electronic structure were performed for CCl4 in the presence of a potassium atom and used to help analyse the lowest unoccupied molecular orbitals participating in the collision process. Potassium 100-109 C-C motif chemokine ligand 4 Homo sapiens 74-78 32193365-3 2020 Mitral and tufted (M/T) neurons from Mitf mutant mice are hyperexcitable, have a reduced Type-A potassium current (IA) and exhibit reduced expression of Kcnd3, which encodes a potassium voltage-gated channel subunit (Kv4.3) important for generating the IA Furthermore, expression of the Mitf and Kcnd3 genes is activity-dependent in OB projection neurons and the MITF protein activates expression from Kcnd3 regulatory elements. Potassium 96-105 melanogenesis associated transcription factor Mus musculus 37-41 31999038-3 2020 Both the NiO5 single-atom active centers and nanotube framework endow the Ni/S/C ternary composite with accelerated reaction kinetics for potassium-ion storage. Potassium 138-147 solute carrier family 5 member 5 Homo sapiens 74-78 32508821-7 2020 NLRP3 inflammasome assembly is triggered by extracellular ATP, reactive oxygen species (ROS), potassium efflux, calcium misbalance, and lysosome disruption. Potassium 94-103 NLR family pyrin domain containing 3 Homo sapiens 0-5 32351384-2 2020 Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting potential and repolarizing action potentials. Potassium 13-22 potassium voltage-gated channel subfamily H member 1 Homo sapiens 44-47 31991212-5 2020 At physiological pH, the degree of elastin mineralization is influenced by hydrolysis and complexity of medium composition, since ionic species, as sodium, potassium, magnesium, in addition to calcium and phosphorus, interfere with the calcification process. Potassium 156-165 elastin Homo sapiens 35-42 31722434-1 2020 STUDY OBJECTIVES: Recently, a role for gain-of-function (GoF) mutations of the astrocytic potassium channel Kir4.1 (KCNJ10 gene) has been proposed in subjects with Autism-Epilepsy phenotype (AEP). Potassium 90-99 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 108-114 31722434-1 2020 STUDY OBJECTIVES: Recently, a role for gain-of-function (GoF) mutations of the astrocytic potassium channel Kir4.1 (KCNJ10 gene) has been proposed in subjects with Autism-Epilepsy phenotype (AEP). Potassium 90-99 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 116-122 32168096-3 2020 Astrocytes grown in hyperglycemic conditions have decreased levels of Kir4.1 potassium channels as well as impaired potassium and glutamate uptake. Potassium 77-86 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 70-76 32292023-5 2020 Genetic analysis demonstrated a novel heterozygous mutation in the SLC12A3 gene; therefore, we diagnosed GS and started potassium and magnesium replacement. Potassium 120-129 solute carrier family 12 member 3 Homo sapiens 67-74 32318578-11 2020 Conclusion: The baseline anti-EPO antibody level combined with an older age and a higher predialysis potassium ion concentration are independent predictors for a higher follow-up EPO demand in maintenance dialysis patients with ESRD. Potassium 101-110 erythropoietin Homo sapiens 30-33 32318578-11 2020 Conclusion: The baseline anti-EPO antibody level combined with an older age and a higher predialysis potassium ion concentration are independent predictors for a higher follow-up EPO demand in maintenance dialysis patients with ESRD. Potassium 101-110 erythropoietin Homo sapiens 179-182 32255892-7 2020 Although maize yield response to fertilizer differed with geographic location; on average, maize yield response to nitrogen (N), phosphorus (P) and potassium (K) were respectively 2.4, 1.6 and 0.2 t ha-1 in Nigeria, 2.3, 0.9 and 0.2 t ha-1 in Ethiopia, and 1.5, 0.8 and 0.2 t ha-1 in Tanzania. Potassium 148-157 1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic Zea mays 199-203 31967857-9 2020 Hypoxia induced changes in CB Type I cell redox ratio affected peptidyl prolyl isomerase Pin1, which is believed to co-localize with the NADPH oxidase subunit p47phox in the cell membrane to trigger the opening of potassium channels. Potassium 214-223 neutrophil cytosolic factor 1 Mus musculus 159-166 31967857-10 2020 We postulate that hypoxia-induced changes in the Fp mediated redox ratio of the CB regulate the Pin1/p47phox tandem to alter Type I cell potassium channels and therewith CND. Potassium 137-146 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Mus musculus 96-100 31967857-10 2020 We postulate that hypoxia-induced changes in the Fp mediated redox ratio of the CB regulate the Pin1/p47phox tandem to alter Type I cell potassium channels and therewith CND. Potassium 137-146 neutrophil cytosolic factor 1 Mus musculus 101-108 31984792-4 2020 We previously showed that the basolateral membrane of principal cells has primarily potassium conductance mediated by Kir4.1/5.1 channels to mediate K+ recycling and to set up a favorable driving force for Na+/K+ exchange. Potassium 84-93 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 118-124 31962128-11 2020 Mechanistically, we showed that potassium-induced cortical spreading depression episodes were inhibited, including frequency and duration of DC shift, in CNO-treated hM4Di-TG mice. Potassium 32-41 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Mus musculus 154-157 32255279-10 2020 When the short-term stability of the serum potassium was observed for 30, 12, and 4 days at 2 - 8 C, room temperature, and 37 C, respectively, b1 < t0.95, n - 2 sb1, and instability was not observed. Potassium 43-52 SH3KBP1 binding protein 1 Homo sapiens 163-166 32160100-4 2020 Here, we show that LSD1 genotype (in humans) and LSD1 deficiency (in mice) lead to similar associations with increased blood pressure and urine potassium levels but with decreased aldosterone levels during a liberal salt diet. Potassium 144-153 lysine demethylase 1A Homo sapiens 19-23 32160100-4 2020 Here, we show that LSD1 genotype (in humans) and LSD1 deficiency (in mice) lead to similar associations with increased blood pressure and urine potassium levels but with decreased aldosterone levels during a liberal salt diet. Potassium 144-153 lysine demethylase 1A Homo sapiens 49-53 32034107-8 2020 In aldosterone-treated NCC knockout mice showing upregulation of pendrin, potassium supplementation corrected alkalosis and inhibited the pendrin upregulation, thereby lowering BP. Potassium 74-83 solute carrier family 26, member 4 Mus musculus 65-72 31692055-3 2020 In this study, we identified two lysine sites, K21 and K123, that were critical ubiquitin-binding sites in BAX. Potassium 55-59 BCL2 associated X, apoptosis regulator Homo sapiens 107-110 32128683-2 2020 Studies in porcine kidney BADH (pkBADH) suggested that the enzyme exhibits heterogeneity of active sites and undergoes potassium-induced conformational changes. Potassium 119-128 aldehyde dehydrogenase 7 family member A1 Homo sapiens 26-30 31439721-5 2020 For functional characterisation of the identified variants, potassium influx of mutated KCC3 cotransporters was measured in Xenopus oocytes. Potassium 60-69 solute carrier family 12 member 6 L homeolog Xenopus laevis 88-92 31439721-9 2020 Modelling of the mutant KCC3 cotransporter in Xenopus oocytes showed a significant reduction in potassium influx for both changes. Potassium 96-105 solute carrier family 12 member 6 L homeolog Xenopus laevis 24-28 32111696-3 2020 Previous work established that cocaine/methamphetamine exposure increases protein phosphatase 2A (PP2A) activity, which dephosphorylates the GABABR2 subunit, promotes internalization of the GABAB receptor (GABABR) and leads to smaller GABABR-activated G-protein-gated inwardly rectifying potassium (GIRK) currents in VTA GABA neurons. Potassium 288-297 protein phosphatase 2, regulatory subunit A, alpha Mus musculus 98-102 32111696-3 2020 Previous work established that cocaine/methamphetamine exposure increases protein phosphatase 2A (PP2A) activity, which dephosphorylates the GABABR2 subunit, promotes internalization of the GABAB receptor (GABABR) and leads to smaller GABABR-activated G-protein-gated inwardly rectifying potassium (GIRK) currents in VTA GABA neurons. Potassium 288-297 gamma-aminobutyric acid type B receptor subunit 2 Rattus norvegicus 141-148 32015077-0 2020 Recognition and activation of the plant AKT1 potassium channel by the kinase CIPK23. Potassium 45-54 K+ transporter 1 Arabidopsis thaliana 40-44 32015077-0 2020 Recognition and activation of the plant AKT1 potassium channel by the kinase CIPK23. Potassium 45-54 CBL-interacting protein kinase 23 Arabidopsis thaliana 77-83 32034107-8 2020 In aldosterone-treated NCC knockout mice showing upregulation of pendrin, potassium supplementation corrected alkalosis and inhibited the pendrin upregulation, thereby lowering BP. Potassium 74-83 solute carrier family 26, member 4 Mus musculus 138-145 32328491-3 2020 However, pathways triggering NLRP3 activation, such as potassium efflux, ROS production or lysosomal permeabilization, can be required or not, depending on the activators used. Potassium 55-64 NLR family pyrin domain containing 3 Homo sapiens 29-34 32270035-1 2020 The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac I Ks currents. Potassium 94-96 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 22-27 31954182-1 2020 Upon transition from research to development, a new chemical entity, which acts upon the Kv1.5-potassium channel and blocks potassium flow in the atrium of the human heart, has been subjected to a crystallization screen. Potassium 95-104 potassium voltage-gated channel subfamily A member 5 Homo sapiens 89-94 31954182-1 2020 Upon transition from research to development, a new chemical entity, which acts upon the Kv1.5-potassium channel and blocks potassium flow in the atrium of the human heart, has been subjected to a crystallization screen. Potassium 124-133 potassium voltage-gated channel subfamily A member 5 Homo sapiens 89-94 32235870-1 2020 Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. Potassium 0-9 aquaporin 2 Rattus norvegicus 28-32 32179729-1 2020 BACKGROUND Insulin lowers not only blood glucose levels but also serum potassium levels by driving potassium into the cells. Potassium 71-80 insulin Homo sapiens 11-18 32270035-1 2020 The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac I Ks currents. Potassium 94-96 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 48-53 32270035-4 2020 Kv7.1 and KCNE1 mutations, responsible for long QT syndromes, impair association and traffic, thereby altering I Ks currents. Potassium 113-115 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-5 32270035-4 2020 Kv7.1 and KCNE1 mutations, responsible for long QT syndromes, impair association and traffic, thereby altering I Ks currents. Potassium 113-115 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 10-15 33997174-1 2021 Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 31-34 32179729-1 2020 BACKGROUND Insulin lowers not only blood glucose levels but also serum potassium levels by driving potassium into the cells. Potassium 99-108 insulin Homo sapiens 11-18 32161292-6 2020 A molecular docking model was proposed in which Arg79 of the SVSP 99-loop interacts directly with the potassium selectivity filter of the hEAG1 channel. Potassium 102-111 potassium voltage-gated channel subfamily H member 1 Homo sapiens 138-143 31984791-2 2020 NHERF1 is involved in the regulation of the sodium hydrogen exchanger 3 (NHE3), the sodium dependent phosphate transporter 2a (Npt2a), and the sodium potassium ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Potassium 143-159 SLC9A3 regulator 1 Homo sapiens 0-6 31866408-6 2020 The effect of HSYA on the large conductance Ca2+ activated and voltage-gated potassium channel (BKCa channel) currents in rat mesentery artery and on L-type calcium channel (Ca-L) currents in HEK293cells expressed with Ca-L were investigated using patch clamp techniques. Potassium 77-86 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 96-100 31984791-2 2020 NHERF1 is involved in the regulation of the sodium hydrogen exchanger 3 (NHE3), the sodium dependent phosphate transporter 2a (Npt2a), and the sodium potassium ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Potassium 143-159 solute carrier family 9 member A3 Homo sapiens 44-71 31984791-2 2020 NHERF1 is involved in the regulation of the sodium hydrogen exchanger 3 (NHE3), the sodium dependent phosphate transporter 2a (Npt2a), and the sodium potassium ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Potassium 143-159 dynein axonemal heavy chain 8 Homo sapiens 160-166 31782179-1 2020 TREK-1 (TWIK-related K+ channel), a member of the two-pore domain K+ (K2P) channel family, is highly expressed in astrocytes, where it plays a key role in glutamate release and passive conductance. Potassium 70-73 potassium two pore domain channel subfamily K member 2 Homo sapiens 0-6 31846835-0 2020 Potassium-dependent sodium-calcium exchanger (NCKX) isoforms and neuronal function. Potassium 0-9 solute carrier family 24 member 1 Homo sapiens 46-50 31868992-4 2020 One of the main challenges of hiPSC-CMs is the physiologic expression of ion channels such as the inward rectifiers (e.g., Kir2.1-2.3), which conduct the cardiac inward rectifier potassium current (IK1 ). Potassium 179-188 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 123-129 31835175-3 2020 We therefore tested the effect of genetic inactivation of K-Cl cotransporters KCC1 and KCC3 in a mouse model of beta-thalassemia intermedia. Potassium 58-62 solute carrier family 12, member 4 Mus musculus 78-82 31835175-3 2020 We therefore tested the effect of genetic inactivation of K-Cl cotransporters KCC1 and KCC3 in a mouse model of beta-thalassemia intermedia. Potassium 58-62 solute carrier family 12, member 6 Mus musculus 87-91 31868992-4 2020 One of the main challenges of hiPSC-CMs is the physiologic expression of ion channels such as the inward rectifiers (e.g., Kir2.1-2.3), which conduct the cardiac inward rectifier potassium current (IK1 ). Potassium 179-188 IKAROS family zinc finger 1 Homo sapiens 198-201 31916164-16 2020 PC2 accounted for 23.81% of the total variance with high loadings on B-As, L-As, K-As, and K-SOD, whereas PC3 showed high loadings on B-Pb, L-Pb, and K-Pb and accounted for 19.04% of the total variance. Potassium 81-85 minisatellite 6 hypermutable 3 Mus musculus 0-3 31916164-15 2020 The first component (PC1) showed high loadings on B-SOD, L-SOD, B-MDA, L-MDA, K-MDA, iNOS, tNOS, and AChE and accounted for 46.55% of the total variance after Varimax rotation. Potassium 78-83 minisatellite 6 hypermutable Mus musculus 21-24 31926846-1 2020 Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) is a rare, developmental and epileptic encephalopathy most commonly associated with mutations in KCNT1, a potassium channel. Potassium 164-173 potassium sodium-activated channel subfamily T member 1 Homo sapiens 155-160 32271402-3 2020 This study aimed to elucidate the mechanism of Potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) in osteogenic differentiation. Potassium 47-56 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 126-134 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 70-79 potassium voltage-gated channel subfamily H member 2 Homo sapiens 12-17 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 70-79 ETS transcription factor ERG Homo sapiens 64-68 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 130-139 potassium voltage-gated channel subfamily H member 2 Homo sapiens 12-17 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 130-139 ETS transcription factor ERG Homo sapiens 64-68 31916164-16 2020 PC2 accounted for 23.81% of the total variance with high loadings on B-As, L-As, K-As, and K-SOD, whereas PC3 showed high loadings on B-Pb, L-Pb, and K-Pb and accounted for 19.04% of the total variance. Potassium 150-154 proprotein convertase subtilisin/kexin type 1 Mus musculus 106-109 32054691-9 2020 This receptor directly regulates pendrin"s total abundance and its relative abundance in the apical membrane region over a wide range in serum potassium concentration. Potassium 143-152 solute carrier family 26, member 4 Mus musculus 33-40 30819023-5 2020 We found that only alpha2 heterozygous mice displayed higher SD susceptibility when challenged with prolonged extracellular high potassium concentration ([K+]o), a pronounced post SD oligemia and higher SD speed in-vivo. Potassium 129-138 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Mus musculus 19-25 31907964-2 2020 Recent investigations have revealed that this syndrome is caused by mutations of ABCC9, which encodes a regulatory subunit of SUR2, an adenosine triphosphate-mediated potassium channel opener, expressed not only in smooth muscle but also in hair follicles. Potassium 167-176 ATP binding cassette subfamily C member 9 Homo sapiens 81-86 31907964-2 2020 Recent investigations have revealed that this syndrome is caused by mutations of ABCC9, which encodes a regulatory subunit of SUR2, an adenosine triphosphate-mediated potassium channel opener, expressed not only in smooth muscle but also in hair follicles. Potassium 167-176 ATP binding cassette subfamily C member 9 Homo sapiens 126-130 31997675-7 2020 The developmental time course of tagged Kv1-4 channel expression corresponds with previously published data on developmental changes in single neuron physiology, thus indicating that protein trap fly strains are a useful tool to analyze developmental regulation of potassium channel expression. Potassium 265-274 Shaker Drosophila melanogaster 40-45 31390869-2 2020 However, the role of lncRNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) in AML progression and its mechanism remain largely unknown. Potassium 28-37 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 107-115 32111087-2 2020 AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis. Potassium 93-102 aquaporin 4 Homo sapiens 0-4 31838022-5 2020 Specifically, we demonstrate that miR-K12-6-5p, an oncoviral mimic of the tumor suppressive miR-15/16 family encoded by human Kaposi sarcoma-associated herpes virus, harbors a noncanonical toxic 6mer seed (position 3-8) and that v-miRNAs are more likely than cellular miRNAs to utilize a noncanonical 6mer seed. Potassium 38-46 membrane associated ring-CH-type finger 8 Homo sapiens 34-37 31838022-5 2020 Specifically, we demonstrate that miR-K12-6-5p, an oncoviral mimic of the tumor suppressive miR-15/16 family encoded by human Kaposi sarcoma-associated herpes virus, harbors a noncanonical toxic 6mer seed (position 3-8) and that v-miRNAs are more likely than cellular miRNAs to utilize a noncanonical 6mer seed. Potassium 38-46 membrane associated ring-CH-type finger 8 Homo sapiens 92-95 31984981-1 2020 The reaction of the potassium aluminyl K[Al(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) with an organic azide generates the aluminium imide complex, K[Al(NONDipp)(NMes)] (Mes = mesityl = 2,4,6-Me3C6H2). Potassium 20-53 nudix hydrolase 4 Homo sapiens 85-93 32093314-0 2020 Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels. Potassium 159-168 ETS transcription factor ERG Rattus norvegicus 24-27 32306673-1 2020 Objective: The purpose of this study was to explore the association between gene in the potassium recycling pathway 4 (KCNQ4) polymorphisms and the susceptibility to noise-induced hearing loss (NIHL) , and analysis the effect of cumulative noise exposure (CNE) and noise exposure duration on this association. Potassium 88-97 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 119-124 32024761-5 2020 Here we experimentally assembled excitable membranes using the dynamic clamp and voltage-gated potassium ionic channels (Kv1.3) expressed in Xenopus oocytes. Potassium 95-104 potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog Xenopus laevis 121-126 32070382-2 2020 The large-conductance Ca2+-activated potassium channels, or BKCa channels, are ubiquitously expressed throughout the central nervous system including the cingulate cortex. Potassium 37-46 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 60-64 32054691-6 2020 With high circulating aldosterone, intercalated cell mineralocorticoid receptor gene ablation directly reduced pendrin"s relative abundance in the apical membrane region and pendrin abundance per cell whether serum potassium was high or low. Potassium 215-224 nuclear receptor subfamily 3, group C, member 2 Mus musculus 53-79 31945449-6 2020 As demonstrated through patch clamp recordings, high Atoh1 expression was associated with significantly decreased proportions of cells with Ih currents, significantly reduced proportions of transient potassium channel currents, and potassium channel currents with a greatly increased mean amplitude, which indicated that EHCLCs with high Atoh1 expression were more mature than those with low Atoh1 expression. Potassium 200-209 atonal bHLH transcription factor 1 Rattus norvegicus 53-58 31945449-6 2020 As demonstrated through patch clamp recordings, high Atoh1 expression was associated with significantly decreased proportions of cells with Ih currents, significantly reduced proportions of transient potassium channel currents, and potassium channel currents with a greatly increased mean amplitude, which indicated that EHCLCs with high Atoh1 expression were more mature than those with low Atoh1 expression. Potassium 232-241 atonal bHLH transcription factor 1 Rattus norvegicus 53-58 31699162-9 2020 Results indicated that KGM, inulin and K+I significantly increased the mucosal layer thickness, mucin density (granule number/crypt) and gene expression of Muc2 as compared with the control. Potassium 39-42 mucin 2 Mus musculus 156-160 31974304-9 2020 Potassium channels in parvalbumin-type models deactivate rapidly and are unavailable for further modulation. Potassium 0-9 parvalbumin Homo sapiens 22-33 31950953-7 2020 The potassium salt 5 was tested for its detonation ability by detonating RDX. Potassium 4-13 radixin Homo sapiens 73-76 31887021-1 2020 Krokinobacter rhodopsin 2 (KR2) serves as a light-driven sodium ion pump in the presence of sodium ion and works as a proton pump in the presence of larger monovalent cations such as potassium ion, rubidium ion, and cesium ion. Potassium 183-192 rhodopsin Homo sapiens 14-23 31765512-4 2020 We were able to tune the strength of the mica-organothiol interactions by exchanging the potassium surface ions for copper ions. Potassium 89-98 MHC class I polypeptide-related sequence A Homo sapiens 41-45 31834838-1 2020 The cardiac potassium IKs current is carried by a channel complex formed from a-subunits encoded by KCNQ1 and b-subunits encoded by KCNE1. Potassium 12-21 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 100-105 31834838-1 2020 The cardiac potassium IKs current is carried by a channel complex formed from a-subunits encoded by KCNQ1 and b-subunits encoded by KCNE1. Potassium 12-21 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 132-137 31913688-9 2020 All together, our results showed that the absence of the HKA2 during gestation leads to an "underfilled" situation and established this transporter as a key player of the renal control of salt and potassium metabolism during gestation. Potassium 197-206 keratin 32 Mus musculus 57-61 32056680-5 2020 DRAD (%) results from the subtraction of potassium from uranium residual values. Potassium 41-50 EGF containing fibulin extracellular matrix protein 1 Homo sapiens 0-4 31756511-0 2020 Human ether-a-go-go-related potassium channel: exploring SAR to improve drug design. Potassium 28-37 sarcosine dehydrogenase Homo sapiens 57-60 31992638-7 2020 As a result, we identified more than 5,000 putative target sites of osmotic stress-activated SnRK2.4 and SnRK2.6, abscisic acid-activated protein kinases SnRK2.6 and casein kinase 1-like 2 (CKL2), elicitor-activated protein kinase CDPK11 and MPK6, cold-activated protein kinase MPK6, H2O2-activated protein kinase OXI1 and MPK6, and salt-induced protein kinase SOS1 and MPK6, as well as the low-potassium-activated protein kinase CIPK23. Potassium 395-404 SOS Ras/Rac guanine nucleotide exchange factor 1 Homo sapiens 361-365 31444588-11 2020 The high positive loadings of PC1 (Cl-, TDS, SO42-, Na+, NO3-, Mg2+ and HCO3-) stand for processes of silicate weathering and dissolution, ion exchange and evaporation, and the influence of domestic waste waters, irrigation return flows and chemical fertilizers on the groundwater system, the PC2 (F- and pH) signifies the alkaline nature of groundwater, which causes fluorosis, and the PC3 (K+) is a result of potassium fertilizers. Potassium 411-420 proprotein convertase subtilisin/kexin type 1 Homo sapiens 30-33 32010303-13 2020 Furthermore, a high concentration of potassium ions significantly reduced the secretion of IL-1beta after induction/stimulation. Potassium 37-46 interleukin 1 alpha Homo sapiens 91-99 31837324-1 2020 Our study proposed to investigate the function of potassium voltage-gated channel sub-family Q member 1 opposite strand 1 (KCNQ1OT1) in cerebral ischemia-reperfusion (I/R) injury and the underlying mechanism. Potassium 50-59 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 123-131 31908015-9 2020 Feeding nephrotic mice with a low potassium diet prevented hyperkaliemia, gamma-ENaC cleavage, and led to persistent increased phosphorylation of NCC. Potassium 34-43 sodium channel, nonvoltage-gated 1 gamma Mus musculus 74-84 31908037-7 2020 Paradoxically, CTRP1-deficient mice had elevated urinary sodium and potassium excretion, partially resulting from reduced expression of genes involved in renal sodium and potassium reabsorption. Potassium 68-77 C1q and tumor necrosis factor related protein 1 Mus musculus 15-20 31908037-7 2020 Paradoxically, CTRP1-deficient mice had elevated urinary sodium and potassium excretion, partially resulting from reduced expression of genes involved in renal sodium and potassium reabsorption. Potassium 171-180 C1q and tumor necrosis factor related protein 1 Mus musculus 15-20 31646445-3 2020 Accumulating investigations imply that chloride efflux-dependent ASC speck oligomerization and potassium efflux-dependent activation of caspase-1 are the two relatively independent, but indispensable events for NLRP3 inflammasome activation. Potassium 95-104 caspase 1 Homo sapiens 136-145 31646445-3 2020 Accumulating investigations imply that chloride efflux-dependent ASC speck oligomerization and potassium efflux-dependent activation of caspase-1 are the two relatively independent, but indispensable events for NLRP3 inflammasome activation. Potassium 95-104 NLR family pyrin domain containing 3 Homo sapiens 211-216 31646445-4 2020 Previous studies suggested that influence of MCC950 on potassium efflux and its consequent events such as interaction between NEK7 and NLRP3 are limited. Potassium 55-64 NIMA related kinase 7 Homo sapiens 126-130 31646445-4 2020 Previous studies suggested that influence of MCC950 on potassium efflux and its consequent events such as interaction between NEK7 and NLRP3 are limited. Potassium 55-64 NLR family pyrin domain containing 3 Homo sapiens 135-140 32016907-3 2020 Angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers (ACE/ARB), diuretics, and proton pump inhibitor (PPI) can interfere with potassium levels in these patients. Potassium 151-160 angiotensin I converting enzyme Homo sapiens 79-82 32016907-3 2020 Angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers (ACE/ARB), diuretics, and proton pump inhibitor (PPI) can interfere with potassium levels in these patients. Potassium 151-160 ATPase H+/K+ transporting subunit alpha Homo sapiens 104-115 31851553-1 2020 KCNMA1, encoding the voltage- and calcium-activated potassium channel, has a pivotal role in brain physiology. Potassium 52-61 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 0-6 32227763-9 2020 RESULTS: The expression of the autophagy-related protein LC3-II was increased and the expression of p62 was decreased in the BS-KS intervention group. Potassium 128-130 nucleoporin 62 Mus musculus 100-103 31748680-5 2020 VEGF (1000 pg/mL) increased the nonselective cation current (INSC) of transient receptor potential (TRP) channels and potassium current of intermediate-conductance Ca2+-activated K+ (KCa3.1) channels thereby upregulating Ca2+ entry. Potassium 118-127 vascular endothelial growth factor A Homo sapiens 0-4 31870500-0 2020 Defective bicarbonate reabsorption in Kir4.2 potassium channel deficient mice impairs acid-base balance and ammonia excretion. Potassium 45-54 potassium inwardly-rectifying channel, subfamily J, member 15 Mus musculus 38-44 31870500-2 2020 Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. Potassium 54-63 potassium inwardly-rectifying channel, subfamily J, member 15 Mus musculus 80-86 31870500-2 2020 Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. Potassium 54-63 potassium inwardly-rectifying channel, subfamily J, member 15 Mus musculus 88-94 31870500-6 2020 Additionally, Kcnj15 deletion depolarized the proximal cell membrane by decreasing the barium-sensitive component of the potassium conductance and caused an intracellular alkalinization. Potassium 121-130 potassium inwardly-rectifying channel, subfamily J, member 15 Mus musculus 14-20 31870500-7 2020 Thus, the Kir4.2 potassium channel subunit is a newly recognized regulator of proximal ammonia metabolism. Potassium 17-26 potassium inwardly-rectifying channel, subfamily J, member 15 Mus musculus 10-16 31668450-0 2020 Potassium Binders for Hyperkalemia in Chronic Kidney Disease-Diet, Renin-Angiotensin-Aldosterone System Inhibitor Therapy, and Hemodialysis. Potassium 0-9 renin Homo sapiens 67-72 31468337-6 2020 Finally, we ran a computational model combining the well-known reduction of potassium current by ghrelin with the CaV3 biophysical parameter modifications induced by ghrelin to predict the impact on neuronal electrical behavior. Potassium 76-85 ghrelin Mus musculus 97-104 31468337-10 2020 Our model-based prediction indicates that the inhibition of CaV3.3 would attenuate the stimulation of firing originating from the inhibition of potassium currents by ghrelin. Potassium 144-153 caveolin 3 Homo sapiens 60-64 31468337-10 2020 Our model-based prediction indicates that the inhibition of CaV3.3 would attenuate the stimulation of firing originating from the inhibition of potassium currents by ghrelin. Potassium 144-153 ghrelin Mus musculus 166-173 31757575-0 2020 High potassium exposure reveals the altered ability of astrocytes to regulate their volume in the aged hippocampus of GFAP/EGFP mice. Potassium 5-14 glial fibrillary acidic protein Mus musculus 118-122 31971671-0 2020 ZIF-8@ZIF-67-Derived Nitrogen-Doped Porous Carbon Confined CoP Polyhedron Targeting Superior Potassium-Ion Storage. Potassium 93-102 caspase recruitment domain family member 16 Homo sapiens 59-62 32118778-1 2020 BACKGROUND: Vonoprazan is a potassium-competitive acid blocker (P-CAB) that is frequently used in Japan for Helicobacter pylori (H. pylori) eradication, treatment of gastroesophageal reflux disease, and treatment of post endoscopic submucosal dissection (ESD) complications. Potassium 28-37 neural proliferation, differentiation and control 1 Homo sapiens 66-69 31669150-7 2020 Compared with controls, MIF-treated HL-1 myocytes had increased calcium transients, sarcoplasmic reticulum (SR) calcium content, Na+/Ca2+ exchanger (NCX) efflux rate, calcium leak, transient outward potassium current, and ultra-rapid delayed rectifier potassium current. Potassium 199-208 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 24-27 32109341-5 2020 SPAK2 and KS-SPAK function to inhibit phosphorylation of cation co-transporters by full length SPAK. Potassium 10-12 serine/threonine kinase 39 Mus musculus 13-17 32109341-6 2020 However, the existence of orthologous SPAK2 or KS-SPAK within the human kidney, and the role of such SPAK isoforms in nephron segment-specific regulation of Na+ reabsorption, still have not been determined. Potassium 47-49 serine/threonine kinase 39 Homo sapiens 50-54 32019062-0 2020 Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice. Potassium 36-45 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 29-35 32019062-3 2020 Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured astrocytes. Potassium 48-57 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 71-77 32019062-6 2020 In diabetic mice, astrocytic Kir4.1 channels were functionally downregulated as evidenced by multiple characteristics including depolarized membrane potential, reduced barium-sensitive Kir currents and impaired potassium uptake capabilities of hippocampal astrocytes. Potassium 211-220 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 29-35 31669150-7 2020 Compared with controls, MIF-treated HL-1 myocytes had increased calcium transients, sarcoplasmic reticulum (SR) calcium content, Na+/Ca2+ exchanger (NCX) efflux rate, calcium leak, transient outward potassium current, and ultra-rapid delayed rectifier potassium current. Potassium 252-261 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 24-27 31654662-0 2020 ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice and rats. Potassium 37-46 potassium voltage-gated channel, subfamily H (eag-related), member 3 Mus musculus 55-61 31996484-4 2020 We report that the US Food and Drug Administration-approved potassium channel blocker 3,4-diaminopyridine (3,4-DAP) reverses respiratory depression and neuromuscular weakness in murine models of acute and chronic botulism. Potassium 60-69 death-associated protein Mus musculus 111-114 31654662-0 2020 ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice and rats. Potassium 37-46 potassium voltage-gated channel, subfamily H (eag-related), member 3 Mus musculus 77-82 31654662-2 2020 In this study, we used animal models of behavior to evaluate the antipsychotic activity of ASP2905, a potent and selective inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. Potassium 140-149 potassium voltage-gated channel, subfamily H (eag-related), member 3 Mus musculus 158-164 31654662-2 2020 In this study, we used animal models of behavior to evaluate the antipsychotic activity of ASP2905, a potent and selective inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. Potassium 140-149 potassium voltage-gated channel, subfamily H (eag-related), member 3 Mus musculus 180-185 32038177-0 2020 The Epilepsy of Infancy With Migrating Focal Seizures: Identification of de novo Mutations of the KCNT2 Gene That Exert Inhibitory Effects on the Corresponding Heteromeric KNa1.1/KNa1.2 Potassium Channel. Potassium 186-195 potassium sodium-activated channel subfamily T member 2 Homo sapiens 98-103 32038177-3 2020 KCNT1 and KCNT2 respectively encode the KNa1.1 (Slack) and KNa1.2 (Slick) subunits of the sodium-dependent voltage-gated potassium channel KNa. Potassium 121-130 potassium sodium-activated channel subfamily T member 1 Homo sapiens 0-5 32038177-3 2020 KCNT1 and KCNT2 respectively encode the KNa1.1 (Slack) and KNa1.2 (Slick) subunits of the sodium-dependent voltage-gated potassium channel KNa. Potassium 121-130 potassium sodium-activated channel subfamily T member 2 Homo sapiens 10-15 31974459-4 2020 Recently, we have suggested that TRPML1-mediated lysosomal exocytosis is essentially dependent on lysosomal big conductance Ca2+-activated potassium (BK) channel. Potassium 139-148 mucolipin 1 Mus musculus 33-39 31880435-9 2020 Preliminary 59Co NMR experiments show that the K+ ion in [K {Co2(Lcat)3}](PF6) can be removed by its competitive complexation with the highly potassium-selective [2.2.2]cryptand, to give a transient 59Co NMR signal of the relatively unstable "empty" {Co2(Lcat)3} complex, which slowly decomposes in solution. Potassium 144-153 sperm associated antigen 17 Homo sapiens 76-79 31948476-0 2020 The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells. Potassium 10-19 potassium voltage-gated channel subfamily H member 2 Homo sapiens 4-8 31837329-2 2020 The aim is to explore the role of lncRNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) and associated novel mechanisms in the progression and chemoresistance of AML. Potassium 41-50 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 120-128 31992966-2 2019 The voltage-gated potassium Kv1.3 channel is of interest, which is considered as a novel therapeutic target for treating neuroinflammatory disorders due to its crucial role in subsets of T lymphocytes as well as microglial cells. Potassium 18-27 potassium voltage-gated channel subfamily A member 3 Homo sapiens 28-33 31866458-6 2020 Blocked hypomethylation increases BMP4 expression and selectively upregulates H3 K4me3 on the Bmp4 promoter, which may explain the effects on HFSC quiescence, hair cycle, and injury repair. Potassium 81-86 bone morphogenetic protein 4 Homo sapiens 94-98 31998284-6 2019 Furthermore, LPC induced pyroptosis in both cells and the activation of the inflammasome with IL-1beta secretion, which was dependent on potassium efflux and lysosomal damage in human monocytes. Potassium 137-146 interleukin 1 alpha Homo sapiens 94-102 32021205-4 2020 Previous studies have suggested that the aquaporin 4(AQP4) and inward rectifier potassium ion channel Kir4.1 (encoded by gene KCNJ10) may act in concert to adjust water homeostasis and concentration of potassium ions in extracellular spaces of the central nervous system. Potassium 80-89 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 102-108 32021205-4 2020 Previous studies have suggested that the aquaporin 4(AQP4) and inward rectifier potassium ion channel Kir4.1 (encoded by gene KCNJ10) may act in concert to adjust water homeostasis and concentration of potassium ions in extracellular spaces of the central nervous system. Potassium 80-89 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 126-132 31691389-2 2020 The photochemical reactions allow the regiospecific and innate late-stage functionalization of helicenes and are easily executed either via the activation of C(sp2)-Br bonds in helicenes using K2CO3 as inorganic base or direct C(sp2)-H helicene bond functionalization under oxidative photoredox reaction conditions. Potassium 193-198 Sp2 transcription factor Homo sapiens 158-163 31936011-11 2020 In all cases, the performance of maize hybrids was maximum under potassium application at 75 kg ha-1. Potassium 65-74 1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic Zea mays 96-100 31744859-0 2020 Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. Potassium 72-81 potassium inwardly rectifying channel subfamily J member 12 Homo sapiens 83-89 31781711-6 2020 Then, we find that humidity improves the resistance of the layers to be squeezed-out and extends the range of loads in which the liquid behaves as a superlubricant, interpreted by an enhanced dissolution of the potassium ions on the mica leading to a larger surface charge. Potassium 211-220 MHC class I polypeptide-related sequence A Homo sapiens 233-237 31919307-8 2020 Three target proteins, i.e. human ether-a-go-go-related (hERG) potassium channel, the inhibitor of apoptosis protein 3 and serine/threonine-protein kinase PIM1, were chosen as the targets. Potassium 63-72 ETS transcription factor ERG Homo sapiens 57-61 32291375-2 2020 However, RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium >5.5 mmol/L). Potassium 203-212 renin Homo sapiens 144-149 32477601-4 2020 In the kidneys of non-anesthetized rats, which received a water load of 2 ml per 100 g of body weight, three effects of vasopressin were revealed: 1) increased reabsorption of water and sodium, 2) increased excretion of potassium ions, and 3) increased excretion of sodium ions. Potassium 220-229 arginine vasopressin Rattus norvegicus 120-131 31839145-1 2020 Kv11.1 potassium channels are essential for heart repolarization. Potassium 7-16 potassium voltage-gated channel modifier subfamily V member 2 Homo sapiens 0-6 31642335-4 2020 Protein inhibitor of activated STAT3 (PIAS3) promoted SUMO1 conjugation at K725 and K739 on nNOS, which upregulated NO production and nNOS S1412 phosphorylation (activation). Potassium 84-88 protein inhibitor of activated STAT 3 Homo sapiens 0-36 31642335-4 2020 Protein inhibitor of activated STAT3 (PIAS3) promoted SUMO1 conjugation at K725 and K739 on nNOS, which upregulated NO production and nNOS S1412 phosphorylation (activation). Potassium 84-88 protein inhibitor of activated STAT 3 Homo sapiens 38-43 31642335-4 2020 Protein inhibitor of activated STAT3 (PIAS3) promoted SUMO1 conjugation at K725 and K739 on nNOS, which upregulated NO production and nNOS S1412 phosphorylation (activation). Potassium 84-88 nitric oxide synthase 1 Homo sapiens 92-96 31642335-4 2020 Protein inhibitor of activated STAT3 (PIAS3) promoted SUMO1 conjugation at K725 and K739 on nNOS, which upregulated NO production and nNOS S1412 phosphorylation (activation). Potassium 84-88 nitric oxide synthase 1 Homo sapiens 134-138 33092407-0 2020 Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4. Potassium 62-71 aquaporin 4 Homo sapiens 144-155 33307724-0 2020 Erratum to "Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4". Potassium 74-83 aquaporin 4 Homo sapiens 156-167 31653347-6 2020 Incubation with beta-d-glucose was associated with glycation of 4 (K-418, K-427, K-434, K-441) out of 6 lysine residues, known to be important for mediating the interaction with plasmin. Potassium 88-93 plasminogen Homo sapiens 178-185 31810890-1 2020 Analogues of the anti-tuberculosis drug bedaquiline, bearing a 3,5-dimethoxy-4-pyridyl C-unit, retain high anti-bacterial potency yet exert less inhibition of the hERG potassium channel, in vitro, than the parent compound. Potassium 168-177 ETS transcription factor ERG Homo sapiens 163-167 32491968-2 2020 Therefore, we sought to clarify whether MD1 can alter the electrophysiological remodeling of cardiac myocytes from obese mice by regulating voltage-gated potassium current and calcium current. Potassium 154-163 lymphocyte antigen 86 Mus musculus 40-43 32491968-10 2020 MD1 deletion led to down-regulated potassium currents and slowed inactivation of L-type calcium channel in an obese mice model. Potassium 35-44 lymphocyte antigen 86 Mus musculus 0-3 31560448-5 2020 Multivariate linear regression showed that the AGT rs699 and CYP11B2 rs1799998 polymorphisms plus baseline serum potassium explained 71% of variability in LVEF improvement (p=0.001), 63% of variability in serum potassium increase (p=2.25E-08), and 39% of the variability in improvement in quality of life (p=2.3E-04) with spironolactone therapy. Potassium 211-220 angiotensinogen Homo sapiens 47-50 31599747-6 2020 Novel nonsteroidal mineralocorticoid receptor antagonists (MRA) are able to lower proteinuria and markers of heart failure, with limited potassium problems and without renal impairment. Potassium 137-146 nuclear receptor subfamily 3 group C member 2 Homo sapiens 19-45 32611299-2 2020 In a previous study, we discovered that zacopride selectively stimulated the inward rectifier potassium current (IK1) in the rat and that agonizing IK1 prevented or eliminated aconitine-induced arrhythmias inrats. Potassium 94-103 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 113-116 31657676-1 2020 The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. Potassium 44-53 ETS transcription factor ERG Homo sapiens 38-42 31657676-1 2020 The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. Potassium 127-136 ETS transcription factor ERG Homo sapiens 38-42 30897577-0 2020 Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux. Potassium 32-41 ATPase H+/K+ transporting subunit alpha Homo sapiens 85-96 31932120-5 2020 Key potassium channelopathies include those affecting the KV, KCa and Kir families, a significant proportion of which have been implicated in neurological disease. Potassium 4-13 casein kappa Homo sapiens 62-65 31932120-5 2020 Key potassium channelopathies include those affecting the KV, KCa and Kir families, a significant proportion of which have been implicated in neurological disease. Potassium 4-13 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 70-73 31914597-1 2020 The Slack (KCNT1) gene encodes sodium-activated potassium channels that are abundantly expressed in the central nervous system. Potassium 48-57 potassium sodium-activated channel subfamily T member 1 Homo sapiens 4-9 31914597-1 2020 The Slack (KCNT1) gene encodes sodium-activated potassium channels that are abundantly expressed in the central nervous system. Potassium 48-57 potassium sodium-activated channel subfamily T member 1 Homo sapiens 11-16 33349065-5 2020 In this article, we present the case of a 47-year-old woman with Bartter syndrome on oral potassium 40 mg BID (twice a day) and magnesium oxide 800 TID (thrice a day), who recently had a small bowel resection that required intravenous potassium and magnesium throughout her hospital admission. Potassium 90-99 BH3 interacting domain death agonist Homo sapiens 106-109 31785237-1 2020 The slow voltage-gated potassium channel (IKs) is composed of the KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Potassium 23-32 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 66-71 31785237-1 2020 The slow voltage-gated potassium channel (IKs) is composed of the KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Potassium 23-32 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 76-81 31730936-4 2020 This emphasizes the pharmacologic properties necessary for TdP but does not account for situations where clinical exposure may be higher, or where hERG potassium channel active metabolites are involved. Potassium 152-161 ETS transcription factor ERG Homo sapiens 147-151 31897736-1 2020 Kv10.1 (Eag1, or KCNH1) is a human potassium-selective channel associated with tumor development. Potassium 35-44 potassium voltage-gated channel subfamily H member 1 Homo sapiens 0-6 31973216-4 2020 Ether a-go-go-1 (Eag1) is a voltage-gated potassium channel involved in cancer. Potassium 42-51 potassium voltage-gated channel subfamily H member 1 Homo sapiens 0-15 31973216-4 2020 Ether a-go-go-1 (Eag1) is a voltage-gated potassium channel involved in cancer. Potassium 42-51 potassium voltage-gated channel subfamily H member 1 Homo sapiens 17-21 31578829-6 2020 Among the other probands, missense SNVs were observed in DCLK2 (Doublecortin Like Kinase 2), HERC2 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2), and KCNH3 (Potassium channel, voltage-gated, subfamily H, member 3). Potassium 174-183 doublecortin like kinase 2 Homo sapiens 57-62 31897736-1 2020 Kv10.1 (Eag1, or KCNH1) is a human potassium-selective channel associated with tumor development. Potassium 35-44 potassium voltage-gated channel subfamily H member 1 Homo sapiens 8-12 31897736-1 2020 Kv10.1 (Eag1, or KCNH1) is a human potassium-selective channel associated with tumor development. Potassium 35-44 potassium voltage-gated channel subfamily H member 1 Homo sapiens 17-22 31919767-1 2020 The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1-7.5). Potassium 40-49 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 95-100 31819014-11 2020 Existing data suggest that I3 receptors may represent a binding site at the Kir6.2-subtype ATP-sensitive potassium channels in pancreatic beta-cells and may be involved in insulin secretion. Potassium 105-114 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 76-82 31782079-0 2020 Zinc finger protein 5 (ZFP5) associates with ethylene signaling to regulate the phosphate and potassium deficiency-induced root hair development in Arabidopsis. Potassium 94-103 zinc finger protein 5 Arabidopsis thaliana 0-21 31782079-0 2020 Zinc finger protein 5 (ZFP5) associates with ethylene signaling to regulate the phosphate and potassium deficiency-induced root hair development in Arabidopsis. Potassium 94-103 zinc finger protein 5 Arabidopsis thaliana 23-27 31782079-1 2020 KEY MESSAGE: Zinc finger protein transcription factor ZFP5 positively regulates root hair elongation in response to Pi and potassium deficiency by mainly activating the expression of EIN2 in Arabidopsis. Potassium 123-132 zinc finger protein 5 Arabidopsis thaliana 54-58 31782079-1 2020 KEY MESSAGE: Zinc finger protein transcription factor ZFP5 positively regulates root hair elongation in response to Pi and potassium deficiency by mainly activating the expression of EIN2 in Arabidopsis. Potassium 123-132 NRAMP metal ion transporter family protein Arabidopsis thaliana 183-187 31782079-7 2020 The significant reduction of root hair length in ein2-1 and ein3-1 as compared to wild-type under Pi and potassium deficiency supports the involvement of ethylene in root hair elongation. Potassium 105-114 NRAMP metal ion transporter family protein Arabidopsis thaliana 49-53 31782079-7 2020 The significant reduction of root hair length in ein2-1 and ein3-1 as compared to wild-type under Pi and potassium deficiency supports the involvement of ethylene in root hair elongation. Potassium 105-114 Ethylene insensitive 3 family protein Arabidopsis thaliana 60-64 31782079-8 2020 Furthermore, the application of 1-aminocyclopropane-1-carboxylic acid (ACC) significantly enhanced the expression level of ZFP5 while the application of 2-aminoethoxyvinyl glycine (AVG) had the opposite effect when either Pi or potassium was deprived. Potassium 228-237 zinc finger protein 5 Arabidopsis thaliana 123-127 31782079-10 2020 Generally, these results suggest that ZFP5 regulates root hair elongation by interacting with ethylene signaling mainly through regulates the expression of EIN2 in response to Pi and potassium deficiency in Arabidopsis. Potassium 183-192 zinc finger protein 5 Arabidopsis thaliana 38-42 31782079-10 2020 Generally, these results suggest that ZFP5 regulates root hair elongation by interacting with ethylene signaling mainly through regulates the expression of EIN2 in response to Pi and potassium deficiency in Arabidopsis. Potassium 183-192 NRAMP metal ion transporter family protein Arabidopsis thaliana 156-160 32419412-0 2020 Increased potassium excretion in children with monosymptomatic nocturnal enuresis: could it be related to Kir 4.1- KCNJ10 gene polymorphism? Potassium 10-19 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 106-113 31724744-8 2020 RESULTS: Extracellular potassium was greater in the irradiated conditions when compared to the nonirradiated controls and was greater in the post-CIG group when compared to the pre-CIG group (p < 0.05). Potassium 23-32 fibronectin 1 Homo sapiens 146-149 31724744-8 2020 RESULTS: Extracellular potassium was greater in the irradiated conditions when compared to the nonirradiated controls and was greater in the post-CIG group when compared to the pre-CIG group (p < 0.05). Potassium 23-32 fibronectin 1 Homo sapiens 181-184 32419412-0 2020 Increased potassium excretion in children with monosymptomatic nocturnal enuresis: could it be related to Kir 4.1- KCNJ10 gene polymorphism? Potassium 10-19 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 115-121 32419412-10 2020 CONCLUSION: We conclude that KCNJ10 gene promoter polymorphism may have a role on potassium excretion in Turkish MNE children. Potassium 82-91 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 29-35 31892729-1 2019 Ginsenoside Rb1 exerts its pharmacological action by regulating sodium, potassium and calcium ion channels in the membranes of nerve cells. Potassium 72-81 RB transcriptional corepressor 1 Homo sapiens 12-15 32835836-9 2020 Multiple regression analysis adjusted for age, body-mass index, and fibrinogen levels showed that anti-FXa activity, antithrombin activity, and FVIII activity determined Ks, while anti-FXa activity, plasminogen activator inhibitor-1 level, and presence of right ventricular dysfunction determined CLT. Potassium 170-172 fibrinogen beta chain Homo sapiens 68-78 32835836-9 2020 Multiple regression analysis adjusted for age, body-mass index, and fibrinogen levels showed that anti-FXa activity, antithrombin activity, and FVIII activity determined Ks, while anti-FXa activity, plasminogen activator inhibitor-1 level, and presence of right ventricular dysfunction determined CLT. Potassium 170-172 coagulation factor X Homo sapiens 103-106 32835836-9 2020 Multiple regression analysis adjusted for age, body-mass index, and fibrinogen levels showed that anti-FXa activity, antithrombin activity, and FVIII activity determined Ks, while anti-FXa activity, plasminogen activator inhibitor-1 level, and presence of right ventricular dysfunction determined CLT. Potassium 170-172 serpin family C member 1 Homo sapiens 117-129 32835836-9 2020 Multiple regression analysis adjusted for age, body-mass index, and fibrinogen levels showed that anti-FXa activity, antithrombin activity, and FVIII activity determined Ks, while anti-FXa activity, plasminogen activator inhibitor-1 level, and presence of right ventricular dysfunction determined CLT. Potassium 170-172 coagulation factor VIII Homo sapiens 144-149 31882877-3 2019 Here, we show that KCTD15, a member of the emerging class of KCTD ((K)potassium Channel Tetramerization Domain containing) proteins, is strongly upregulated in patients affected by B-cell type acute lymphoblastic leukemia (B-ALL) and in continuous cell lines (RS4;11, REH, TOM-1, SEM) derived from this form of childhood leukemia. Potassium 70-79 potassium channel tetramerization domain containing 15 Homo sapiens 19-25 31882877-3 2019 Here, we show that KCTD15, a member of the emerging class of KCTD ((K)potassium Channel Tetramerization Domain containing) proteins, is strongly upregulated in patients affected by B-cell type acute lymphoblastic leukemia (B-ALL) and in continuous cell lines (RS4;11, REH, TOM-1, SEM) derived from this form of childhood leukemia. Potassium 70-79 target of myb1 membrane trafficking protein Homo sapiens 273-278 31882846-1 2019 The hERG potassium channel influences ventricular action potential duration. Potassium 9-18 ETS transcription factor ERG Homo sapiens 4-8 31874991-3 2019 The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit underlying cardiac rapidly delayed rectifier potassium current (IKr). Potassium 125-134 potassium voltage-gated channel subfamily H member 2 Homo sapiens 40-45 31892729-5 2019 The results showed that Rb1 inhibited INa and ICaL, reduced the action potential amplitude (APA) and maximum upstroke velocity (Vmax), and shortened the action potential duration (APD) in a concentration-dependent manner but had no effect on the inward rectifier potassium current (IK1), delayed rectifier potassium current (IK) or resting membrane potential (RMP). Potassium 263-272 RB transcriptional corepressor 1 Homo sapiens 24-27 31892729-5 2019 The results showed that Rb1 inhibited INa and ICaL, reduced the action potential amplitude (APA) and maximum upstroke velocity (Vmax), and shortened the action potential duration (APD) in a concentration-dependent manner but had no effect on the inward rectifier potassium current (IK1), delayed rectifier potassium current (IK) or resting membrane potential (RMP). Potassium 306-315 RB transcriptional corepressor 1 Homo sapiens 24-27 31655646-4 2019 Surprisingly, a stable and strong ECL signal was obtained based on the RET, which was used for signal-off detection of FA in the presence of coreactant K2S2O8. Potassium 152-158 ret proto-oncogene Homo sapiens 71-74 31799617-11 2019 These studies revealed that the knockout of Kcnj16 markedly altered RAAS regulation and function, suggesting Kir5.1 as a key regulator of the RAAS, particularly when exposed to changes in dietary sodium and potassium content. Potassium 207-216 potassium inwardly-rectifying channel, subfamily J, member 16 Rattus norvegicus 44-50 31761909-0 2019 Prediction of two-dimensional PC6 as a promising anode material for potassium-ion batteries. Potassium 68-77 proprotein convertase subtilisin/kexin type 5 Homo sapiens 30-33 31761909-8 2019 These appealing properties render the PC6 monolayer an excellent anode candidate for potassium-ion batteries. Potassium 85-94 proprotein convertase subtilisin/kexin type 5 Homo sapiens 38-41 31863007-4 2019 Here, we identify PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4). Potassium 71-77 polybromo 1 Homo sapiens 18-23 31863007-4 2019 Here, we identify PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4). Potassium 71-77 tumor protein p53 Homo sapiens 40-43 31863007-5 2019 Notably, mutations on key residues of BD4 disrupt recognition of p53 K382Ac. Potassium 69-75 tumor protein p53 Homo sapiens 65-68 31863061-0 2019 The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK. Potassium 56-65 uromodulin Mus musculus 25-35 31863061-0 2019 The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK. Potassium 56-65 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 74-78 31863061-2 2019 Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Potassium 41-50 uromodulin Mus musculus 0-10 31863061-2 2019 Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Potassium 41-50 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 59-63 31863073-0 2019 Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion. Potassium 101-110 CAP, adenylate cyclase-associated protein, 2 (yeast) Mus musculus 32-36 31863073-0 2019 Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion. Potassium 101-110 transmembrane protease, serine 4 Mus musculus 37-44 31861703-0 2019 Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5. Potassium 52-61 potassium voltage-gated channel subfamily A member 5 Homo sapiens 86-91 31861703-1 2019 The voltage-gated potassium channel Kv1.5, which mediates the cardiac ultra-rapid delayed-rectifier (IKur) current in human cells, has a crucial role in atrial fibrillation. Potassium 18-27 potassium voltage-gated channel subfamily A member 5 Homo sapiens 36-41 31938690-2 2019 KATP channels were formed by potassium ion-passing pore-forming subunits (Kir6.1, Kir6.2) and regulatory subunits SUR1, SU2A and SUR2B. Potassium 29-38 potassium inwardly-rectifying channel, subfamily J, member 8 Rattus norvegicus 74-80 31730143-8 2019 Through this chip based method, stable current recordings through inward rectifier potassium (Kir) ion channels embedded in rat basophilic leukemia (RBL-1) cell membrane are achieved with high electrical sealing resistance (over 1 GOmega). Potassium 83-92 RB transcriptional corepressor like 1 Rattus norvegicus 149-154 31890149-4 2019 Whole-cell patch-clamp experiment showed that Ktx-Sp2 peptide could effectively block three types of exogenous voltage-gated potassium channels-Kv1.1, Kv1.2 and Kv1.3, among which, the blocking activity for Kv1.3 was relatively high, showing selectivity to some extent. Potassium 125-134 potassium voltage-gated channel subfamily A member 1 Homo sapiens 144-149 31890149-4 2019 Whole-cell patch-clamp experiment showed that Ktx-Sp2 peptide could effectively block three types of exogenous voltage-gated potassium channels-Kv1.1, Kv1.2 and Kv1.3, among which, the blocking activity for Kv1.3 was relatively high, showing selectivity to some extent. Potassium 125-134 potassium voltage-gated channel subfamily A member 2 Homo sapiens 151-156 31890149-4 2019 Whole-cell patch-clamp experiment showed that Ktx-Sp2 peptide could effectively block three types of exogenous voltage-gated potassium channels-Kv1.1, Kv1.2 and Kv1.3, among which, the blocking activity for Kv1.3 was relatively high, showing selectivity to some extent. Potassium 125-134 potassium voltage-gated channel subfamily A member 3 Homo sapiens 161-166 31669729-5 2019 In the present study, we investigated the functional effect of these variants on the potassium channel Kir2.1 and the significance of the double mutation. Potassium 85-94 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 103-109 31892810-3 2019 On the other hand, whereas other inflammasomes are mainly detectors of specific molecular motifs, NLRP3 is acting as a general sensor of cellular perturbations including potassium efflux, lysosomal damage, and ROS production. Potassium 170-179 NLR family pyrin domain containing 3 Homo sapiens 98-103 31767767-5 2019 Here, we identify a detailed working mechanism of how the homeodomain-like transcription factor NSY-7, previously described as a repressor in the maintenance of AWC asymmetry, couples SLO BK potassium channels to transactivation of sox-2 expression for the induction of the AWCON subtype through the identification of a unique imb-2 (transportin 1) allele. Potassium 191-200 SRY-box transcription factor 2 Homo sapiens 232-237 31767767-5 2019 Here, we identify a detailed working mechanism of how the homeodomain-like transcription factor NSY-7, previously described as a repressor in the maintenance of AWC asymmetry, couples SLO BK potassium channels to transactivation of sox-2 expression for the induction of the AWCON subtype through the identification of a unique imb-2 (transportin 1) allele. Potassium 191-200 transportin 1 Homo sapiens 334-347 31767767-8 2019 This study provides mechanistic insight into how NSY-7 couples SLO BK potassium channels to transactivation of sox-2 expression for the induction of the AWCON subtype. Potassium 70-79 SRY-box transcription factor 2 Homo sapiens 111-116 31799617-11 2019 These studies revealed that the knockout of Kcnj16 markedly altered RAAS regulation and function, suggesting Kir5.1 as a key regulator of the RAAS, particularly when exposed to changes in dietary sodium and potassium content. Potassium 207-216 potassium inwardly-rectifying channel, subfamily J, member 16 Rattus norvegicus 109-115 31815668-1 2019 Up-regulation of the persistent sodium current (INaP) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). Potassium 81-90 solute carrier family 12 member 5 Rattus norvegicus 109-113 31835299-8 2019 In addition, ion analysis showed that opr7opr8 accumulated less sodium but more potassium in the leaves than WT but more sodium and less potassium in the roots than WT, suggesting that JA deficiency causes higher salt stress to the roots but less stress to the leaves of the seedlings. Potassium 80-89 12-oxophytodienoate reductase7 Zea mays 38-46 31835299-8 2019 In addition, ion analysis showed that opr7opr8 accumulated less sodium but more potassium in the leaves than WT but more sodium and less potassium in the roots than WT, suggesting that JA deficiency causes higher salt stress to the roots but less stress to the leaves of the seedlings. Potassium 137-146 12-oxophytodienoate reductase7 Zea mays 38-46 31701097-0 2019 In silico investigation of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP1. Potassium 69-78 potassium voltage-gated channel subfamily D member 3 Homo sapiens 87-92 31701097-0 2019 In silico investigation of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP1. Potassium 69-78 potassium voltage-gated channel interacting protein 1 Homo sapiens 119-125 31701097-1 2019 The voltage-gated potassium channel Kv4.3 plays a vital role in shaping the timing, frequency, and backpropagation of electrical signals in the brain and heart by generating fast transient currents at subthreshold membrane potentials in repetitive firing neurons. Potassium 18-27 potassium voltage-gated channel subfamily D member 3 Homo sapiens 36-41 31701097-2 2019 To achieve its physiological function, Kv4.3 is assisted by auxiliary beta-subunits that become integral parts of the native A-type potassium channels, among which there are the Kv channel-interacting proteins (KChIPs). Potassium 132-141 potassium voltage-gated channel subfamily D member 3 Homo sapiens 39-44 31600170-0 2019 KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. Potassium 6-15 potassium voltage-gated channel subfamily D member 3 Homo sapiens 0-5 31558613-6 2019 Inflammasome activation by PAF also requires potassium efflux and calcium influx but not lysosomal cathepsin or mitochondrial reactive oxygen species. Potassium 45-54 PCNA clamp associated factor Homo sapiens 27-30 31810225-4 2019 In particular, TASK-3 (KCNK9), a member of the K2P potassium channel family, has attracted much interest because of its oncogenic properties. Potassium 51-60 potassium two pore domain channel subfamily K member 9 Homo sapiens 23-28 31630908-3 2019 Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas. Potassium 94-103 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 19-25 31630908-3 2019 Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas. Potassium 94-103 potassium two pore domain channel subfamily K member 4 Rattus norvegicus 30-35 31630908-3 2019 Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas. Potassium 105-108 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 19-25 31630908-3 2019 Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas. Potassium 105-108 potassium two pore domain channel subfamily K member 4 Rattus norvegicus 30-35 31657247-5 2019 The increase in abundance of Na+/H+ exchanger 3 (NHE3) or activated Na+-K+-2Cl- cotransporter 2 (NKCC2-P) predicted significant reductions in urinary Na+ excretion, yet there was no observed change in urine Na+. Potassium 72-78 solute carrier family 12 member 1 Rattus norvegicus 97-102 31664867-1 2019 There is significant interest in the potential utility of small molecule activator compounds to mitigate cardiac arrhythmia caused by loss-of-function of hERG1a voltage-gated potassium channels. Potassium 175-184 potassium voltage-gated channel subfamily H member 2 Homo sapiens 154-159 31742594-1 2019 The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. Potassium 13-22 potassium two pore domain channel subfamily K member 18 Homo sapiens 32-37 31600826-1 2019 OBJECTIVE: Pathogenic variants in KCNB1, encoding the voltage-gated potassium channel KV 2.1, are associated with developmental and epileptic encephalopathy (DEE). Potassium 68-77 potassium voltage-gated channel subfamily B member 1 Homo sapiens 34-39 31610034-14 2019 All three mutants cloned in Xenopus oocytes caused an aberrant modulation of the mechano-gated potassium channel, TREK-1. Potassium 95-104 potassium channel, two pore domain subfamily K, member 2 S homeolog Xenopus laevis 114-120 31625414-3 2019 Here, we hypothesized that lncRNA potassium voltage-gated channel subfamily q member 1 overlapping transcript 1 (KCNQ1OT1) could affect the development of MI via regulation of Runt-related transcription factor (RUNX)3 by methylation. Potassium 34-43 KCNQ1 overlapping transcript 1 Mus musculus 113-121 31682765-0 2019 Complexes formed with integrin-alpha5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling. Potassium 48-57 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 42-47 31682765-0 2019 Complexes formed with integrin-alpha5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling. Potassium 48-57 thymoma viral proto-oncogene 1 Mus musculus 153-156 31682765-1 2019 Voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 complexes (IKCs)-in the human brain, but their function was poorly understood. Potassium 14-23 potassium voltage-gated channel subfamily B member 1 Homo sapiens 59-64 31682765-1 2019 Voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 complexes (IKCs)-in the human brain, but their function was poorly understood. Potassium 14-23 potassium voltage-gated channel subfamily B member 1 Homo sapiens 66-71 31682765-1 2019 Voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 complexes (IKCs)-in the human brain, but their function was poorly understood. Potassium 14-23 integrin subunit alpha 5 Homo sapiens 129-144 31682765-1 2019 Voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 complexes (IKCs)-in the human brain, but their function was poorly understood. Potassium 14-23 potassium voltage-gated channel subfamily B member 1 Homo sapiens 145-150 31638180-0 2019 Adipose-derived stem cells overexpressing SK4 calcium-activated potassium channel generate biological pacemakers. Potassium 64-73 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 42-45 31624998-0 2019 The Potassium Channel Kv1.5 Expression Alters During Experimental Autoimmune Encephalomyelitis. Potassium 4-13 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 22-27 31612994-0 2019 Shaw and Shal voltage-gated potassium channels mediate circadian changes in Drosophila clock neuron excitability. Potassium 28-37 Shaker cognate l Drosophila melanogaster 9-13 31612994-4 2019 We show that currents mediated by the voltage-gated potassium channels Shaw (Kv3) and Shal (Kv4) oscillate in a circadian manner. Potassium 52-61 Shaker cognate w Drosophila melanogaster 71-75 31612994-4 2019 We show that currents mediated by the voltage-gated potassium channels Shaw (Kv3) and Shal (Kv4) oscillate in a circadian manner. Potassium 52-61 Shaker cognate w Drosophila melanogaster 77-80 31612994-4 2019 We show that currents mediated by the voltage-gated potassium channels Shaw (Kv3) and Shal (Kv4) oscillate in a circadian manner. Potassium 52-61 Shaker cognate l Drosophila melanogaster 86-90 31612994-4 2019 We show that currents mediated by the voltage-gated potassium channels Shaw (Kv3) and Shal (Kv4) oscillate in a circadian manner. Potassium 52-61 Shaker cognate l Drosophila melanogaster 92-95 31190144-10 2019 Intraocular injection of potassium in wild-type mice led to visual function hyperactivity, as observed in Aqp4 KO mice. Potassium 25-34 aquaporin 4 Mus musculus 106-110 31190144-12 2019 AQP4 may fine-tune synaptic activity, most likely by regulating potassium metabolism, at least in part, via collaborating with KIR2.1, and possibly indirectly regulating glutamate kinetics, to inhibit neural hyperactivity and synaptic fatigue which finally affect mitochondria and cause neurodegeneration. Potassium 64-73 aquaporin 4 Mus musculus 0-4 31624998-3 2019 It was shown that voltage-gated potassium channels Kv1.5 are responsible for fine-tuning in the immune physiology and influence proliferation and differentiation in microglia and astrocytes. Potassium 32-41 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 51-56 31795491-3 2019 The encoded proteins Kelch-like 3 and Cullin 3 interact to form a ring-like complex to ubiquitinate WNK-kinase 4, which, in normal circumstances, interacts with the sodium chloride co-symporter (NCC), the epithelial sodium channel (ENaC), and the renal outer medullary potassium channel (ROMK) in an inhibitory manner to maintain normokalaemia and normotension. Potassium 269-278 cullin 3 Homo sapiens 38-46 31814333-9 2019 Finally, we demonstrate that DCPIB activates ATP-inhibitable potassium channels comprised of heterologously expressed Kir6.2 and SUR1 subunits. Potassium 61-70 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 118-124 31814333-9 2019 Finally, we demonstrate that DCPIB activates ATP-inhibitable potassium channels comprised of heterologously expressed Kir6.2 and SUR1 subunits. Potassium 61-70 ATP binding cassette subfamily C member 8 Homo sapiens 129-133 31832048-0 2019 The Shaker Type Potassium Channel, GORK, Regulates Abscisic Acid Signaling in Arabidopsis. Potassium 16-25 gated outwardly-rectifying K+ channel Arabidopsis thaliana 35-39 31832048-4 2019 In this study, we report that the shaker type potassium (K+) channel, GORK, modulates plant responses to ABA and abiotic stresses. Potassium 46-55 gated outwardly-rectifying K+ channel Arabidopsis thaliana 70-74 31795491-3 2019 The encoded proteins Kelch-like 3 and Cullin 3 interact to form a ring-like complex to ubiquitinate WNK-kinase 4, which, in normal circumstances, interacts with the sodium chloride co-symporter (NCC), the epithelial sodium channel (ENaC), and the renal outer medullary potassium channel (ROMK) in an inhibitory manner to maintain normokalaemia and normotension. Potassium 269-278 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 288-292 31849684-10 2019 These results suggest that activation of alpha7nAChR with anisodamine could decrease serum potassium and on-site mortality in CS through estradiol-induced enhancement of insulin sensitivity. Potassium 91-100 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-52 31657415-1 2019 The indyl anion, K[In(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) reacts with group 12 compounds M(BDIR)Cl (M = Zn, Cd; BDI = [HC{C(Me)NR}2]-, R = 2,4,6-Me3C6H2 (Mes), Dipp) to afford the heterobimetallic compounds (NONDipp)In-M(BDIR) that contain the first In-Zn and In-Cd bonds. Potassium 17-31 nudix hydrolase 3 Homo sapiens 36-40 31827438-2 2019 We explored if blocking the background and the acetylcholine-activated inward rectifier potassium currents (IK1 and IKACh) could be antiarrhythmic in persistent atrial fibrillation. Potassium 88-97 IKAROS family zinc finger 1 Homo sapiens 108-111 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Potassium 140-149 KiSS-1 metastasis-suppressor Mus musculus 63-73 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Potassium 140-149 KiSS-1 metastasis-suppressor Mus musculus 210-220 31819513-0 2019 The Long Non-Coding RNA-14327.1 Promotes Migration and Invasion Potential of Endometrial Carcinoma Cells by Stabilizing the Potassium Channel Kca3.1. Potassium 124-133 potassium calcium-activated channel subfamily N member 4 Homo sapiens 142-148 31819513-1 2019 Background: The intermediate-conductance Ca2+-activated potassium channel (Kca3.1) plays a key role in maintaining intracellular Ca2+ homeostasis and is involved with the carcinogenesis of many human tumors including endometrial carcinoma. Potassium 56-65 potassium calcium-activated channel subfamily N member 4 Homo sapiens 75-81 31594866-1 2019 The association of plasma membrane (PM)-localized voltage-gated potassium (Kv2) channels with endoplasmic reticulum (ER)-localized vesicle-associated membrane protein-associated proteins VAPA and VAPB defines ER-PM junctions in mammalian brain neurons. Potassium 64-73 VAMP associated protein A Homo sapiens 187-191 31801305-2 2019 We recently devised a model of large-conductance BKCa potassium currents, and hence BKCa-CaV complexes controlled locally by CaVs via Ca2+ nanodomains. Potassium 54-63 caveolin 2 Homo sapiens 89-92 31771292-3 2019 This study examined the effectiveness of RIPC in a mouse model of hepatic IR and aimed to clarify the mechanism and relationship of the ATP-sensitive potassium channel (KATP) and HMGB1-induced TLR4/MyD88/NF-kappaB signaling. Potassium 150-159 high mobility group box 1 Mus musculus 179-184 31771292-3 2019 This study examined the effectiveness of RIPC in a mouse model of hepatic IR and aimed to clarify the mechanism and relationship of the ATP-sensitive potassium channel (KATP) and HMGB1-induced TLR4/MyD88/NF-kappaB signaling. Potassium 150-159 toll-like receptor 4 Mus musculus 193-197 31771292-3 2019 This study examined the effectiveness of RIPC in a mouse model of hepatic IR and aimed to clarify the mechanism and relationship of the ATP-sensitive potassium channel (KATP) and HMGB1-induced TLR4/MyD88/NF-kappaB signaling. Potassium 150-159 myeloid differentiation primary response gene 88 Mus musculus 198-203 31771292-3 2019 This study examined the effectiveness of RIPC in a mouse model of hepatic IR and aimed to clarify the mechanism and relationship of the ATP-sensitive potassium channel (KATP) and HMGB1-induced TLR4/MyD88/NF-kappaB signaling. Potassium 150-159 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 204-213 31771312-1 2019 TWIK-related potassium channel-1 (TREK-1) is broadly expressed in the brain and involved in diverse brain diseases, such as seizures, ischemia, and depression. Potassium 13-22 potassium channel, subfamily K, member 2 Mus musculus 34-40 31768497-8 2019 Single guide RNAs expressed from the duplicated promoter mediated edits in the N. benthamiana Phytoene desaturase gene, the S. viridis Carbonic anhydrase 2 gene, and the maize HKT1 gene encoding a potassium transporter. Potassium 197-206 Cation transporter HKT8-like Zea mays 176-180 31472317-5 2019 As a result, the electrochemical properties of the potassium ion battery are enhanced when an AC@CoP/NCNTs/CNFs nanocomposite is used as the anode electrode, and the electrode exhibits a reversible capacity of 247 mA h g-1 after 1000 cycles at 0.8 A g-1 in a potassium ion battery. Potassium 51-60 caspase recruitment domain family member 16 Homo sapiens 97-100 31472317-5 2019 As a result, the electrochemical properties of the potassium ion battery are enhanced when an AC@CoP/NCNTs/CNFs nanocomposite is used as the anode electrode, and the electrode exhibits a reversible capacity of 247 mA h g-1 after 1000 cycles at 0.8 A g-1 in a potassium ion battery. Potassium 259-268 caspase recruitment domain family member 16 Homo sapiens 97-100 31803246-12 2019 These suggest that KCNQ1 and SCN2A, genes that encode potassium and sodium channels, respectively, may serve as putative diagnostic targets for the diagnosis and prognosis of PHEO and therefore facilitate the clinical management of PHEO. Potassium 54-63 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 19-24 31803246-12 2019 These suggest that KCNQ1 and SCN2A, genes that encode potassium and sodium channels, respectively, may serve as putative diagnostic targets for the diagnosis and prognosis of PHEO and therefore facilitate the clinical management of PHEO. Potassium 54-63 sodium voltage-gated channel alpha subunit 2 Homo sapiens 29-34 31803058-2 2019 SA4503, known as a sigma1 receptor agonist, regulates cardiac calcium and potassium channels in rat models of depression. Potassium 74-83 sigma non-opioid intracellular receptor 1 Rattus norvegicus 19-34 31780884-3 2019 To date, and directly relevant to the present review, sigma1R has been found to regulate both voltage-gated ion channels (VGICs) belonging to distinct superfamilies (i.e., sodium, Na+; potassium, K+; and calcium, Ca2+ channels) and non-voltage-gated ion channels. Potassium 185-194 sigma non-opioid intracellular receptor 1 Homo sapiens 54-61 31787993-6 2019 Key Results: 10 muM AVG treatment increases K15NO3 uptake and 15N translocation during root growth inhibition whereas 10 muM AVG + 1 mM 15Nglutamate treatment inhibits K15NO3 uptake and increases 15Nglutamate uptake during partial root growth restoration. Potassium 44-50 latexin Homo sapiens 16-19 31787993-6 2019 Key Results: 10 muM AVG treatment increases K15NO3 uptake and 15N translocation during root growth inhibition whereas 10 muM AVG + 1 mM 15Nglutamate treatment inhibits K15NO3 uptake and increases 15Nglutamate uptake during partial root growth restoration. Potassium 168-174 latexin Homo sapiens 121-124 31594866-1 2019 The association of plasma membrane (PM)-localized voltage-gated potassium (Kv2) channels with endoplasmic reticulum (ER)-localized vesicle-associated membrane protein-associated proteins VAPA and VAPB defines ER-PM junctions in mammalian brain neurons. Potassium 64-73 VAMP associated protein B and C Homo sapiens 196-200 31807018-0 2019 The hERG1 Potassium Channel Behaves As Prognostic Factor In Gastric Dysplasia Endoscopic Samples. Potassium 10-19 potassium voltage-gated channel subfamily H member 2 Homo sapiens 4-9 31706919-0 2021 The role of P-glycoprotein (P-gp) and inwardly rectifying potassium (Kir) channels in sudden unexpected death in epilepsy (SUDEP). Potassium 58-67 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 69-72 31706919-5 2021 Other molecular regulators of membrane potential are the inwardly rectifying potassium channels (Kir), whose genetic variants have been related to both epilepsy and heart dysfunctions. Potassium 77-86 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 97-100 31657282-4 2019 The aim of this study is to estimate the longitudinal association between hypertension diagnosis and subsequent changes (within 2-4 years) in dietary sodium, potassium, and sodium-potassium (Na/K) ratio. Potassium 180-189 TANK binding kinase 1 Homo sapiens 191-195 31695023-4 2019 Studies conducted in the last eight years have identified somatic driver mutations in a substantial portion of aldosterone-producing adenomas, including the genes KCNJ5 (encoding inwardly rectifying potassium channel GIRK4), CACNA1D (encoding a subunit of L-type voltage-gated calcium channel CaV1.3), ATP1A1 (encoding a subunit of Na+/K+-ATPase), ATP2B3 (encoding a Ca2+-ATPase), and CTNNB1 (encoding ss-catenin). Potassium 199-208 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 163-168 31665287-4 2019 In mouse sperm, the potassium current has been conclusively shown to be carried by a channel consisting of the pore forming subunit SLO3 and auxiliary subunit leucine-rich repeat-containing 52 (LRRC52). Potassium 20-29 potassium channel, subfamily U, member 1 Mus musculus 132-136 31665287-4 2019 In mouse sperm, the potassium current has been conclusively shown to be carried by a channel consisting of the pore forming subunit SLO3 and auxiliary subunit leucine-rich repeat-containing 52 (LRRC52). Potassium 20-29 leucine rich repeat containing 52 Mus musculus 159-192 31665287-4 2019 In mouse sperm, the potassium current has been conclusively shown to be carried by a channel consisting of the pore forming subunit SLO3 and auxiliary subunit leucine-rich repeat-containing 52 (LRRC52). Potassium 20-29 leucine rich repeat containing 52 Mus musculus 194-200 31685809-8 2019 In order to better characterize the physiologic role and modulation mechanisms of KCASH2, we have searched through a proteomic approach for new KCASH2 interactors, identifying Potassium Channel Tetramerization Domain Containing 15 (KCTD15). Potassium 176-185 potassium channel tetramerization domain containing 21 Homo sapiens 82-88 31879517-8 2019 The modulation of PCS on IK was through regulation of the phosphorylation of the major potassium ion channel protein Kv2.1. Potassium 87-96 potassium voltage-gated channel subfamily B member 1 Homo sapiens 117-122 31162688-4 2019 Here, we review the evidence of PACAP-dependent modulation of calcium- and voltage-gated potassium currents, hyperpolarization-activated cation currents, calcium currents, and voltage-gated sodium currents. Potassium 89-98 adenylate cyclase activating polypeptide 1 Homo sapiens 32-37 31347753-3 2019 This study proposes an artificial neural network (ANN) for noninvasive electrocardiography-based classification of the hERG potassium-channel block. Potassium 124-133 ETS transcription factor ERG Homo sapiens 119-123 31659098-1 2019 BACKGROUND/AIM: hERG potassium channels enhance tumor invasiveness and breast cancer proliferation. Potassium 21-30 ETS transcription factor ERG Homo sapiens 16-20 31669719-2 2019 KV1.3 ion channel is a voltage-gated potassium channel and has been validated as a drug target for autoimmune and chronic inflammatory diseases like psoriasis. Potassium 37-46 potassium voltage-gated channel subfamily A member 3 Homo sapiens 0-5 31408542-0 2019 Melatonin receptor activation protects against low potassium-induced ventricular fibrillation by preserving action potentials and connexin-43 topology in isolated rat hearts. Potassium 51-60 gap junction protein, alpha 1 Rattus norvegicus 130-141 31526813-6 2019 Effects of reference compounds were in accordance with the literature, indicating the presence of hERG potassium (dofetilide), sodium (mexiletine) and calcium (nifedipine) channels and alpha-adrenergic receptors (isoproterenol). Potassium 103-112 ETS transcription factor ERG Homo sapiens 98-102 31408542-3 2019 We hypothesized that melatonin protects against low potassium-induced arrhythmias through the activation of its receptors, resulting in action potential shortening and connexin-43 preservation. Potassium 52-61 gap junction protein, alpha 1 Rattus norvegicus 168-179 31369814-5 2019 In isolated femoral arteries from endothelial nitric oxide synthase knockout (eNOS-/-) mice, RV had no overall effect on FMD, but potentiated ACh induced dilation, that was completely abolished by potassium channel blockers, Apamin and Tram 34 (p < 0.01). Potassium 197-206 nitric oxide synthase 3, endothelial cell Mus musculus 78-82 31731488-1 2019 The ubiquitously expressed family of inward rectifier potassium (KIR) channels, encoded by KCNJ genes, is primarily involved in cell excitability and potassium homeostasis. Potassium 54-63 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 65-68 31731488-1 2019 The ubiquitously expressed family of inward rectifier potassium (KIR) channels, encoded by KCNJ genes, is primarily involved in cell excitability and potassium homeostasis. Potassium 150-159 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 65-68 31424260-6 2019 Four of the differentially expressed genes (Per1, Nr4a1, Nr4a3, Kcna5) belong to circadian rhythm pathways, aldosterone synthesis and secretion, PI3K-Akt signaling pathway and potassium homeostasis. Potassium 176-185 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 50-55 31424260-6 2019 Four of the differentially expressed genes (Per1, Nr4a1, Nr4a3, Kcna5) belong to circadian rhythm pathways, aldosterone synthesis and secretion, PI3K-Akt signaling pathway and potassium homeostasis. Potassium 176-185 nuclear receptor subfamily 4, group A, member 3 Rattus norvegicus 57-62 31424260-6 2019 Four of the differentially expressed genes (Per1, Nr4a1, Nr4a3, Kcna5) belong to circadian rhythm pathways, aldosterone synthesis and secretion, PI3K-Akt signaling pathway and potassium homeostasis. Potassium 176-185 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 64-69 31649201-4 2019 The structural and functional analyses, along with computational studies, reveal one potassium site and two chloride sites in KCC1, which are all required for the ion transport activity. Potassium 85-94 solute carrier family 12 member 4 Homo sapiens 126-130 31772770-0 2019 GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents. Potassium 63-72 glucagon Rattus norvegicus 0-5 31640787-1 2019 BACKGROUND: Dysfunction in inwardly rectifying potassium channel Kir4.1 has been implicated in SeSAME syndrome, an autosomal-recessive (AR), rare, multi-systemic disorder. Potassium 47-56 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 65-71 31635148-0 2019 N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels. Potassium 50-59 potassium two pore domain channel subfamily K member 2 Homo sapiens 19-25 31635148-1 2019 Mechanosensitive hTREK-1 two-pore-domain potassium (hK2P2.1) channels give rise to background currents that control cellular excitability. Potassium 41-50 potassium two pore domain channel subfamily K member 2 Homo sapiens 17-24 31635148-9 2019 Detection of glycosylation-deficient mutant channels in surface fractions and recordings of macroscopic potassium currents mediated by these subunits demonstrated that nonglycosylated hTREK-1 channel subunits are able to reach the cell surface in general but with seemingly reduced efficiency compared to glycosylated subunits. Potassium 104-113 potassium two pore domain channel subfamily K member 2 Homo sapiens 184-191 31623161-8 2019 We show that normal functioning of ClC-7 supports the acidification process, is associated with increased luminal concentrations of sodium, potassium, and chloride, and leads to a higher Ca2+ uptake and release. Potassium 140-149 chloride voltage-gated channel 7 Homo sapiens 35-40 31570602-2 2019 Here, we discovered that hypotensive folk medicines from a genetically diverse range of plant species each selectively activated the vascular-expressed KCNQ5 potassium channel, a feature lacking in the modern synthetic pharmacopeia, whereas nonhypotensive plant extracts did not. Potassium 158-167 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 152-157 31708743-2 2019 In this study, we found that pan-histone deacetylase (HDAC) inhibition by TSA, SAHA, VPA, and M344 led to a remarkable decrease in the phosphorylation of JNK and c-Jun, concomitant with a significant abrogation of apoptosis caused by potassium deprivation in cultured cerebellar granule neurons (CGNs). Potassium 234-243 mitogen-activated protein kinase 8 Rattus norvegicus 154-157 31708743-6 2019 Functionally, HDAC4 inhibition via knockdown or LMK235 significantly rescued CGN apoptosis induced by potassium deprivation. Potassium 102-111 histone deacetylase 4 Rattus norvegicus 14-19 31708743-6 2019 Functionally, HDAC4 inhibition via knockdown or LMK235 significantly rescued CGN apoptosis induced by potassium deprivation. Potassium 102-111 cingulin Rattus norvegicus 77-80 31680980-0 2019 Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. Potassium 0-9 renin Rattus norvegicus 47-52 31680980-0 2019 Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. Potassium 0-9 angiotensin I converting enzyme 2 Rattus norvegicus 96-100 31680980-0 2019 Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. Potassium 0-9 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 105-110 31680980-0 2019 Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. Potassium 0-9 angiotensinogen Rattus norvegicus 129-143 31570602-5 2019 Discovery of botanical KCNQ5-selective potassium channel openers may enable future targeted therapies for diseases including hypertension and KCNQ5 loss-of-function encephalopathy. Potassium 39-48 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 23-28 31570602-5 2019 Discovery of botanical KCNQ5-selective potassium channel openers may enable future targeted therapies for diseases including hypertension and KCNQ5 loss-of-function encephalopathy. Potassium 39-48 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 142-147 31614948-6 2019 The nutrient-to-energy ratio for vitamins A, B1, B2, B6, C, folate and minerals Calcium, copper, iron, magnesium, phosphorus, potassium and zinc increased significantly. Potassium 126-135 immunoglobulin kappa variable 5-2 Homo sapiens 33-55 31601020-0 2019 Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels. Potassium 6-15 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 109-112 31601020-2 2019 In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephrons. Potassium 107-116 hyperpolarization activated cyclic nucleotide gated potassium channel 1 Homo sapiens 15-19 31601020-2 2019 In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephrons. Potassium 107-116 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Homo sapiens 21-25 31601020-2 2019 In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephrons. Potassium 107-116 hyperpolarization activated cyclic nucleotide gated potassium channel 3 Homo sapiens 30-34 31591393-0 2019 Correction: Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Potassium 31-40 potassium voltage-gated channel subfamily B member 1 Homo sapiens 25-30 31511304-1 2019 Inwardly rectifying potassium (Kir) channels play a key role in controlling membrane potentials in excitable and unexcitable cells, thereby regulating a plethora of physiological processes. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 31-34 31553596-2 2019 Here, a simple strategy of partial congener substitution is introduced to induce transformation of the known centrosymmetric K3Ga3Ge7Se20 (P21/c) to the new isostructural NCS species K3Ga3(Ge6.17Sn0.83)Se20 (1) and K3Ga3(Ge4.95Si2.05)Se20 (2) (Pc). Potassium 125-130 H3 histone pseudogene 16 Homo sapiens 139-144 31553596-2 2019 Here, a simple strategy of partial congener substitution is introduced to induce transformation of the known centrosymmetric K3Ga3Ge7Se20 (P21/c) to the new isostructural NCS species K3Ga3(Ge6.17Sn0.83)Se20 (1) and K3Ga3(Ge4.95Si2.05)Se20 (2) (Pc). Potassium 183-188 H3 histone pseudogene 16 Homo sapiens 139-144 31686980-11 2019 Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day. Potassium 140-149 C-X-C motif chemokine ligand 8 Homo sapiens 80-84 30446179-8 2019 Alterations in metabolic pathways associated with the sensitivity of sodium, potassium, magnesium and calcium may lead to obesity, hypertension, and insulin resistance. Potassium 77-86 insulin Homo sapiens 149-156 31632394-4 2019 This process is partially mediated through the potassium efflux-dependent, cytosolic, PYCARD-containing inflammasome protein complex. Potassium 47-56 PYD and CARD domain containing Homo sapiens 86-92 31632394-6 2019 Using the NLRP3 inflammasome-deficient Raw 264.7 and PYCARD-deficient J77 macrophages, which both lack PYCARD, we found that the potassium efflux activator nigericin enhances bacterial killing. Potassium 129-138 NLR family pyrin domain containing 3 Homo sapiens 10-15 31632394-6 2019 Using the NLRP3 inflammasome-deficient Raw 264.7 and PYCARD-deficient J77 macrophages, which both lack PYCARD, we found that the potassium efflux activator nigericin enhances bacterial killing. Potassium 129-138 PYD and CARD domain containing Homo sapiens 53-59 31004291-7 2019 After being treated with etoricoxib, the serum potassium level of the patient increased rapidly to the normal range which corresponded with the reduction in his serum PGE2 and PE2 metabolite (PGEM) levels. Potassium 47-56 ETS2 repressor factor Homo sapiens 176-179 31038230-3 2019 Recently, we reported on hypoexcitability and increased cell death in a FUS/SOD1-ALS-induced pluripotent stem cell-derived motor neuron model, which was partly reversible by a treatment with the potassium channel blocker 4-aminopyridine (4-AP). Potassium 195-204 FUS RNA binding protein Homo sapiens 72-75 31038230-3 2019 Recently, we reported on hypoexcitability and increased cell death in a FUS/SOD1-ALS-induced pluripotent stem cell-derived motor neuron model, which was partly reversible by a treatment with the potassium channel blocker 4-aminopyridine (4-AP). Potassium 195-204 superoxide dismutase 1 Homo sapiens 76-80 31212067-2 2019 One example of such a channelopathy is the reduction of A-type potassium currents in the hippocampal CA1 region. Potassium 63-72 carbonic anhydrase 1 Mus musculus 101-104 31212067-4 2019 Here, we show that inhibiting a single microRNA, miR-324-5p, which targets the pore-forming A-type potassium channel subunit Kv4.2, selectively increased A-type potassium currents in hippocampal CA1 pyramidal neurons in mice. Potassium 99-108 microRNA 324 Mus musculus 49-56 31212067-4 2019 Here, we show that inhibiting a single microRNA, miR-324-5p, which targets the pore-forming A-type potassium channel subunit Kv4.2, selectively increased A-type potassium currents in hippocampal CA1 pyramidal neurons in mice. Potassium 99-108 potassium voltage-gated channel, Shal-related family, member 2 Mus musculus 125-130 31212067-4 2019 Here, we show that inhibiting a single microRNA, miR-324-5p, which targets the pore-forming A-type potassium channel subunit Kv4.2, selectively increased A-type potassium currents in hippocampal CA1 pyramidal neurons in mice. Potassium 99-108 carbonic anhydrase 1 Mus musculus 195-198 31612103-0 2019 Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer. Potassium 14-23 potassium voltage-gated channel subfamily A member 3 Homo sapiens 32-37 31511966-1 2019 The TWIK-related K+ channel (TREK-1) is a two-pore-domain potassium channel that produces background leaky potassium currents. Potassium 58-67 potassium channel, subfamily K, member 2 Mus musculus 29-35 31425886-9 2019 Ks correlated with fibrinogen-gamma and PF4 amounts within plasma clots. Potassium 0-2 platelet factor 4 Homo sapiens 40-43 31562289-8 2019 We conclude that this Gjb2 mutation-induced hearing loss results from 1) reduced cochlear amplifier caused by lowered EP, 2) IHCs excitotoxicity associated with potassium accumulation around hair cells, and 3) progression induced by environmental insults. Potassium 161-170 gap junction protein, beta 2 Mus musculus 22-26 31612103-1 2019 Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential. Potassium 14-23 potassium voltage-gated channel subfamily A member 3 Homo sapiens 32-37 31612103-1 2019 Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential. Potassium 106-115 potassium voltage-gated channel subfamily A member 3 Homo sapiens 32-37 31616316-8 2019 Among 19 commonly affected genes in comparison with human AF, downregulation of FOXP1 and upregulation of the KCNK2 gene encoding the Kir2.1 potassium channel were conspicuous findings, suggesting NFAT activation. Potassium 141-150 potassium two pore domain channel subfamily K member 2 Homo sapiens 110-115 31559333-4 2019 Materials and Methods: Potassium channel activity in AtT20 FlpIn cells transfected with human CB1 or CB2 receptors was measured in real time using FLIPR membrane potential dye in a FlexStation 3 plate reader. Potassium 23-32 cannabinoid receptor 1 Homo sapiens 94-97 31559333-4 2019 Materials and Methods: Potassium channel activity in AtT20 FlpIn cells transfected with human CB1 or CB2 receptors was measured in real time using FLIPR membrane potential dye in a FlexStation 3 plate reader. Potassium 23-32 cannabinoid receptor 2 Homo sapiens 101-104 31342621-0 2019 High-Throughput Production of Zr-Doped Li4 Ti5 O12 Modified by Mesoporous Libaf3 Nanoparticles for Superior Lithium and Potassium Storage. Potassium 120-129 lipase family member N Homo sapiens 39-42 31616316-8 2019 Among 19 commonly affected genes in comparison with human AF, downregulation of FOXP1 and upregulation of the KCNK2 gene encoding the Kir2.1 potassium channel were conspicuous findings, suggesting NFAT activation. Potassium 141-150 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 134-140 31616316-8 2019 Among 19 commonly affected genes in comparison with human AF, downregulation of FOXP1 and upregulation of the KCNK2 gene encoding the Kir2.1 potassium channel were conspicuous findings, suggesting NFAT activation. Potassium 141-150 nuclear factor of activated T-cells 5 Rattus norvegicus 197-201 31486928-3 2019 The transmembrane water channel AQP1 is important for cardiorespiratory endurance (CE) because it influences fluid transfers in erythrocytes, endothelial, and pulmonary cells and is vital for transport of ammonium, bicarbonate, carbon dioxide, glycerol, nitric oxide, potassium ion, water, and trans-epithelial and renal water. Potassium 268-277 aquaporin 1 Mus musculus 32-36 31854846-15 2019 In addition, EC1 also had stronger interrelation with potassium. Potassium 54-63 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 13-16 31172810-9 2019 Nicotine induced premature hypertension, renal expression of the sodium-potassium chloride cotransporter (NKCC2), increases in renal sodium retention, and infiltration of CD161a+/CD68+ macrophages into the renal medulla. Potassium 72-81 solute carrier family 12 member 1 Rattus norvegicus 106-111 31479495-7 2019 We also determined that MAYV triggers NLRP3 inflammasome activation by inducing reactive oxygen species (ROS) and potassium efflux. Potassium 114-123 NLR family pyrin domain containing 3 Homo sapiens 38-43 31498767-0 2019 ACE inhibitors and ARBs: Managing potassium and renal function. Potassium 34-43 angiotensin I converting enzyme Homo sapiens 0-3 31136755-0 2019 Erv14 cargo receptor participates in regulation of plasma-membrane potential, intracellular pH and potassium homeostasis via its interaction with K+-specific transporters Trk1 and Tok1. Potassium 99-108 Trk1p Saccharomyces cerevisiae S288C 171-175 31136755-0 2019 Erv14 cargo receptor participates in regulation of plasma-membrane potential, intracellular pH and potassium homeostasis via its interaction with K+-specific transporters Trk1 and Tok1. Potassium 99-108 Tok1p Saccharomyces cerevisiae S288C 180-184 31409147-0 2019 Oligodendrocyte Kir4.1 Channels Clear Out Congested K. Oligodendrocytes Control Potassium Accumulation in White Matter and Seizure Susceptibility. Potassium 80-89 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 16-22 31374572-5 2019 Increased catalase activities, NADH/NAD+ ratio and contents of several metals, especially potassium, were observed by YCR102C overexpression under acetic acid stress. Potassium 90-99 uncharacterized protein Saccharomyces cerevisiae S288C 118-125 31700971-5 2019 The potassium level has dropped gradually to a normal level with continuous insulin infusion and dextrose for almost 12 hours that waved the need of the dialysis. Potassium 4-13 insulin Homo sapiens 76-83 31085235-12 2019 Further, PACAP blocks voltage-dependent potassium currents via the adenylyl cyclase/protein kinase A signaling pathway. Potassium 40-49 adenylate cyclase activating polypeptide 1 Rattus norvegicus 9-14 31085235-12 2019 Further, PACAP blocks voltage-dependent potassium currents via the adenylyl cyclase/protein kinase A signaling pathway. Potassium 40-49 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 84-100 33391853-23 2019 KS was given a diagnosis of clinical stage T1b, N0, grade 2 invasive micropapillary carcinoma: ER positive (Allred 6), PR positive (Allred 8), HER2/neu, immunohistochemistry 3+, and fluorescence in situ hybridization amplified.After discussion of this recurrent cancer diagnosis, her team opted for a bilateral diagnostic mammogram (with abdominal shielding) and bilateral axillary and breast ultrasound to evaluate the contralateral breast and lymph nodes. Potassium 0-2 estrogen receptor 1 Homo sapiens 95-97 33391853-23 2019 KS was given a diagnosis of clinical stage T1b, N0, grade 2 invasive micropapillary carcinoma: ER positive (Allred 6), PR positive (Allred 8), HER2/neu, immunohistochemistry 3+, and fluorescence in situ hybridization amplified.After discussion of this recurrent cancer diagnosis, her team opted for a bilateral diagnostic mammogram (with abdominal shielding) and bilateral axillary and breast ultrasound to evaluate the contralateral breast and lymph nodes. Potassium 0-2 erb-b2 receptor tyrosine kinase 2 Homo sapiens 143-147 33391853-23 2019 KS was given a diagnosis of clinical stage T1b, N0, grade 2 invasive micropapillary carcinoma: ER positive (Allred 6), PR positive (Allred 8), HER2/neu, immunohistochemistry 3+, and fluorescence in situ hybridization amplified.After discussion of this recurrent cancer diagnosis, her team opted for a bilateral diagnostic mammogram (with abdominal shielding) and bilateral axillary and breast ultrasound to evaluate the contralateral breast and lymph nodes. Potassium 0-2 erb-b2 receptor tyrosine kinase 2 Homo sapiens 148-151 30897250-7 2019 This mechanism also promotes IL-1beta release and potassium efflux that connects caspase-11 to NLRP3 activation. Potassium 50-59 NLR family pyrin domain containing 3 Homo sapiens 95-100 31624723-11 2019 The relative abundance of beta-glucuronidase (K01195) was higher in female IL-10 KO mice than that in female WT mice by PICRUSt. Potassium 46-52 glucuronidase, beta Mus musculus 26-44 31624723-11 2019 The relative abundance of beta-glucuronidase (K01195) was higher in female IL-10 KO mice than that in female WT mice by PICRUSt. Potassium 46-52 interleukin 10 Mus musculus 75-80 31270663-2 2019 Voltage-dependent potassium conductances such as those formed by Kv1.1 are important for the ability of VOR circuit elements to encode highly transient motion components. Potassium 18-27 potassium channel, voltage gated shaker related subfamily A, member 1 S homeolog Xenopus laevis 65-70 31446696-13 2019 KMT2D and KDM6A are two pathogenic genes that have been identified for KS. Potassium 71-73 lysine methyltransferase 2D Homo sapiens 0-5 31446696-13 2019 KMT2D and KDM6A are two pathogenic genes that have been identified for KS. Potassium 71-73 lysine demethylase 6A Homo sapiens 10-15 30901316-1 2019 Hypokalemic periodic paralysis (HOKPP) is a rare neuromuscular disorder caused by altered transport of cellular potassium that leads to significant muscle weakness of the extremities. Potassium 112-121 calcium voltage-gated channel subunit alpha1 S Homo sapiens 32-37 31555089-8 2019 For the in vitro analysis, primary cortical neurons with NEK7-shRNA were stimulated with lipopolysaccharide (LPS)/ATP or potassium (K+). Potassium 121-130 NIMA (never in mitosis gene a)-related expressed kinase 7 Mus musculus 57-61 31434872-2 2019 Most KCNQ4 mutations linked to hearing loss are clustered around the pore region of the protein and lead to loss of KCNQ4-mediated potassium currents. Potassium 131-140 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 5-10 31461851-1 2019 The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. Potassium 79-88 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 13-18 31461851-1 2019 The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. Potassium 79-88 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 23-28 31361119-5 2019 The superior sodium/potassium storage performance of the OC/SeS2 composite electrodes stems from their rational chemical structure design, including high electrical conductivity of the N-doped organic carbon network and chemical binding with SeS2 molecules. Potassium 20-29 secernin 2 Homo sapiens 60-64 31361119-6 2019 As a result, the OC/SeS2 cathode delivers a reversible capacity of 416 mAh g-1 after 700 cycles for sodium-ion batteries and 216 mAh g-1 after 500 cycles for potassium-ion batteries at 0.5 A g-1, respectively. Potassium 158-167 secernin 2 Homo sapiens 20-24 31434872-2 2019 Most KCNQ4 mutations linked to hearing loss are clustered around the pore region of the protein and lead to loss of KCNQ4-mediated potassium currents. Potassium 131-140 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 116-121 31053371-5 2019 After treatment with an injection of calcium gluconate, insulin with glucose, bicarbonate, and an enema with polystyrene sulfonate, the patient"s serum potassium level normalized and the bradyarrhythmia converted to a normal sinus rhythm. Potassium 152-161 insulin Homo sapiens 56-63 31241995-4 2019 Cellular expression of two APOL1 RRVs has been demonstrated to induce cytotoxicity, including necrosis, apoptosis, and pyroptosis in several cell types including podocytes; mechanistically, these toxicities were attributed to lysosomal swelling, potassium-depletion, mitochondrial dysfunction, autophagy blockade, PKR activation, UBD degradation, and ER stress; notably, these effects were found to be dose-dependent and occurred only in overtly APOL1 RRVs-expressing cells. Potassium 246-255 apolipoprotein L1 Homo sapiens 27-32 31303267-4 2019 PCP-administered GLAST wild-type (+/+) mice showed enhancement of immobility in a forced swimming test, impairments of visual recognition memory in a novel object recognition test, decrease in high potassium (K+)-induced extracellular glutamate release, and overexpression of GLAST and S100 proteins in the PFC, compared to saline-administered GLAST+/+ mice. Potassium 198-207 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Mus musculus 17-22 31253715-5 2019 Specifically, targeted RNAi knock-down of either Para fast voltage-gated sodium, Shaker potassium (Kv1 homologue), or surprisingly, L-type like calcium channels counteracts postnatal increases in GF axonal conduction velocity. Potassium 88-97 Shaker Drosophila melanogaster 99-102 30872118-9 2019 APOE-dependent NLRP3 inflammasome activation in macrophages was primarily mediated through a potassium efflux-dependent mechanism. Potassium 93-102 apolipoprotein E Mus musculus 0-4 30872118-9 2019 APOE-dependent NLRP3 inflammasome activation in macrophages was primarily mediated through a potassium efflux-dependent mechanism. Potassium 93-102 NLR family pyrin domain containing 3 Homo sapiens 15-20 31239388-2 2019 The role of Kir5.1 (encoded by Kcnj16) in mediating effects of dietary potassium intake on the NCC and renal potassium excretion is unknown. Potassium 71-80 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 31-37 31239388-0 2019 Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake. Potassium 52-61 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 12-18 31239388-0 2019 Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake. Potassium 87-96 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 12-18 31239388-1 2019 BACKGROUND: The basolateral potassium channel in the distal convoluted tubule (DCT), comprising the inwardly rectifying potassium channel Kir4.1/Kir5.1 heterotetramer, plays a key role in mediating the effect of dietary potassium intake on the thiazide-sensitive NaCl cotransporter (NCC). Potassium 28-37 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 138-144 31239388-1 2019 BACKGROUND: The basolateral potassium channel in the distal convoluted tubule (DCT), comprising the inwardly rectifying potassium channel Kir4.1/Kir5.1 heterotetramer, plays a key role in mediating the effect of dietary potassium intake on the thiazide-sensitive NaCl cotransporter (NCC). Potassium 28-37 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 145-151 31239388-2 2019 The role of Kir5.1 (encoded by Kcnj16) in mediating effects of dietary potassium intake on the NCC and renal potassium excretion is unknown. Potassium 71-80 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 12-18 31239388-5 2019 Compared with wild-type, Kcnj16-/- mice fed a normal potassium diet had higher basolateral potassium conductance, a more negative DCT membrane potential, higher expression of phosphorylated NCC (pNCC) and total NCC (tNCC), and augmented thiazide-induced natriuresis. Potassium 53-62 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-5 2019 Compared with wild-type, Kcnj16-/- mice fed a normal potassium diet had higher basolateral potassium conductance, a more negative DCT membrane potential, higher expression of phosphorylated NCC (pNCC) and total NCC (tNCC), and augmented thiazide-induced natriuresis. Potassium 91-100 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-9 2019 Compared with wild-type, Kcnj16-/- mice with normal potassium intake had slightly lower plasma potassium but were more hyperkalemic with prolonged high potassium intake and more hypokalemic during potassium restriction. Potassium 52-61 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-9 2019 Compared with wild-type, Kcnj16-/- mice with normal potassium intake had slightly lower plasma potassium but were more hyperkalemic with prolonged high potassium intake and more hypokalemic during potassium restriction. Potassium 95-104 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-9 2019 Compared with wild-type, Kcnj16-/- mice with normal potassium intake had slightly lower plasma potassium but were more hyperkalemic with prolonged high potassium intake and more hypokalemic during potassium restriction. Potassium 95-104 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-9 2019 Compared with wild-type, Kcnj16-/- mice with normal potassium intake had slightly lower plasma potassium but were more hyperkalemic with prolonged high potassium intake and more hypokalemic during potassium restriction. Potassium 95-104 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 25-31 31239388-10 2019 CONCLUSIONS: Kir5.1 is essential for dietary potassium"s effect on NCC and for maintaining potassium homeostasis. Potassium 45-54 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 13-19 31239388-10 2019 CONCLUSIONS: Kir5.1 is essential for dietary potassium"s effect on NCC and for maintaining potassium homeostasis. Potassium 91-100 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 13-19 29513112-9 2019 The Atp1a2+/-G301R MCA constricted stronger to U46619, endothelin and potassium compared to WT. Potassium 70-79 ATPase, Na+/K+ transporting, alpha 2 polypeptide Mus musculus 4-10 31466741-0 2019 Effect of heat stress and Hsp90 inhibition on T-type calcium currents and voltage-dependent potassium currents in leydig cells. Potassium 92-101 heat shock protein 86, pseudogene 1 Mus musculus 26-31 30964070-8 2019 The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. Potassium 69-78 fibroblast growth factor 20 Mus musculus 24-51 30887515-10 2019 In conclusion, our data suggested that potassium currents might play a role in the maintenance of overall S17 cell ionic homeostasis directly affecting cell survival and migration. Potassium 39-48 sperm associated antigen 5 Mus musculus 106-109 31101453-7 2019 Whether conservation of osmotic homeostasis by LETM1 occurs by extrusion of excess mitochondrial potassium (K+), calcium (Ca2+), or both has been a matter of dispute over the past 10 years. Potassium 97-106 leucine zipper and EF-hand containing transmembrane protein 1 Homo sapiens 47-52 30849204-9 2019 The kr and Ks values were 0.027 mg L-1 min-1 and 0.621 L/mg, respectively. Potassium 11-13 L1 cell adhesion molecule Homo sapiens 35-45 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 interleukin 1 beta Homo sapiens 53-61 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 tumor necrosis factor Homo sapiens 63-71 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 interleukin 6 Homo sapiens 73-77 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 interferon alpha 1 Homo sapiens 82-90 31346773-3 2019 We show in this work that the activity of this transporter is regulated at the posttranslational level, and thus Trk1 contributes to potassium uptake under very different external cation concentrations. Potassium 133-142 Trk1p Saccharomyces cerevisiae S288C 113-117 31357463-5 2019 The results of modelling showed that mumax = 0.179 1/h and Ks = 11.37 g.L-1 for the Monod model, whereas mumax = 0.508 1/h, Ks = 47.53 g.L-1 and Ki = 181.01 g.L-1 for the Andrews model, which are too close to the values reported in previous studies. Potassium 59-61 immunoglobulin kappa variable 1-16 Homo sapiens 72-75 31145900-3 2019 For example, NKCC2 resorbs chloride with sodium and potassium ions at the apical membrane of epithelial cells in the kidney, whereas KCC3 releases chloride with potassium ions at the basolateral membrane. Potassium 52-61 solute carrier family 12 member 1 Homo sapiens 13-18 31145900-3 2019 For example, NKCC2 resorbs chloride with sodium and potassium ions at the apical membrane of epithelial cells in the kidney, whereas KCC3 releases chloride with potassium ions at the basolateral membrane. Potassium 161-170 solute carrier family 12 member 6 Homo sapiens 133-137 31082369-4 2019 Chloroquine also inhibited the outward potassium currents from MDA-MB-231 cells, which are mainly carried through Kv10.1 channels as was confirmed using astemizole. Potassium 39-48 potassium voltage-gated channel modifier subfamily G member 3 Homo sapiens 114-120 31296940-0 2019 Evidence for potassium transport activity of Arabidopsis KEA1-KEA6. Potassium 13-22 K+ efflux antiporter 1 Arabidopsis thaliana 57-61 31061086-13 2019 This study uncovers a hitherto uncharacterized consequence of rhodopsin mislocalization: the activation of the lysosomal pathway, which negatively regulates the amount of the sodium-potassium ATPase (NKAalpha) on the inner segment plasma membrane. Potassium 182-191 rhodopsin Homo sapiens 62-71 31208990-0 2019 Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh). Potassium 122-131 G protein subunit beta 5 Homo sapiens 21-25 31636949-4 2019 Through systematic profiling studies, we show that human SIRT3 displays class-selective histone de-beta-hydroxybutyrylase activities with preference for H3 K4, K9, K18, K23, K27, and H4K16, but not for H4 K5, K8, K12, which distinguishes it from the Zn-dependent HDACs. Potassium 156-158 sirtuin 3 Homo sapiens 57-62 31636949-4 2019 Through systematic profiling studies, we show that human SIRT3 displays class-selective histone de-beta-hydroxybutyrylase activities with preference for H3 K4, K9, K18, K23, K27, and H4K16, but not for H4 K5, K8, K12, which distinguishes it from the Zn-dependent HDACs. Potassium 205-207 sirtuin 3 Homo sapiens 57-62 31283756-5 2019 Applied to data from two FDA funded studies (22+22 subjects, 5232+4208 ECGs) which target ECG effects of various ion-channel blocking drugs, the TrX effect profiles indicate increasingly delayed electrical activity over the entire repolarization process for drugs solely reducing outward potassium current (dofetilide, moxifloxacin). Potassium 288-297 thioredoxin Homo sapiens 145-148 31269062-10 2019 The treatment with V2R antagonist (V2A) in the presence and absence of OT induced diuresis, sodium and potassium outflow. Potassium 103-112 arginine vasopressin receptor 2 Rattus norvegicus 19-22 31237175-9 2019 Urinary potassium strongly correlated with urinary AGT ( P<0.0001). Potassium 8-17 angiotensinogen Homo sapiens 51-54 31946488-2 2019 The SQT1, SQT2 and SQT3 variants of the SQTS result from inherited gain-of-function mutations (e.g. N588K, V307L and D172N, respectively) to potassium channels. Potassium 141-150 potassium voltage-gated channel subfamily H member 2 Homo sapiens 4-8 31946488-2 2019 The SQT1, SQT2 and SQT3 variants of the SQTS result from inherited gain-of-function mutations (e.g. N588K, V307L and D172N, respectively) to potassium channels. Potassium 141-150 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 10-14 31946488-2 2019 The SQT1, SQT2 and SQT3 variants of the SQTS result from inherited gain-of-function mutations (e.g. N588K, V307L and D172N, respectively) to potassium channels. Potassium 141-150 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 19-23 31946747-2 2019 Previous experimental studies have shown that biological pacemaker could be produced by genetically manipulating non-pacemaking cardiac cells by suppressing the inward rectifier potassium current (IK1) and expressing the hyperpolarization- activated current (If). Potassium 178-187 IKAROS family zinc finger 1 Homo sapiens 197-200 30919496-5 2019 Values of Km , alpha, n, and Ks for the immobilized enzyme were calculated to be 1.25 x 10-2 microM, 0.56, 3.19, and 0.28 Sec-1 , respectively. Potassium 29-31 secretory blood group 1, pseudogene Homo sapiens 123-128 30865168-9 2019 SUMMARY: Chloride sensing by WNK kinase provides a mechanism to allow coupling of extracellular potassium with NCC phosphorylation and activity to maintain potassium homeostasis. Potassium 96-105 Wnk kinase Drosophila melanogaster 29-32 30865168-9 2019 SUMMARY: Chloride sensing by WNK kinase provides a mechanism to allow coupling of extracellular potassium with NCC phosphorylation and activity to maintain potassium homeostasis. Potassium 156-165 Wnk kinase Drosophila melanogaster 29-32 30919410-8 2019 Additionally, our results suggest that B. abortus-induced IL-1beta secretion depends on a P2X7-independent potassium efflux, lysosomal acidification, cathepsin release, mechanisms clearly associated to NLRP3 inflammasome. Potassium 107-116 interleukin 1 beta Mus musculus 58-66 30883902-2 2019 Vascular endothelial growth factor (VEGF), an original biological substance of vessels, regulates the movement of calcium and potassium ions across neuronal membrane. Potassium 126-135 vascular endothelial growth factor A Homo sapiens 0-34 30883902-2 2019 Vascular endothelial growth factor (VEGF), an original biological substance of vessels, regulates the movement of calcium and potassium ions across neuronal membrane. Potassium 126-135 vascular endothelial growth factor A Homo sapiens 36-40 30230667-3 2019 The advent of new therapeutics aimed at lowering serum potassium has raised the possibility of optimising potassium control to enable greater use of renin-angiotensin-aldosterone system inhibitors in the management of CKD. Potassium 55-64 renin Homo sapiens 149-154 30230667-3 2019 The advent of new therapeutics aimed at lowering serum potassium has raised the possibility of optimising potassium control to enable greater use of renin-angiotensin-aldosterone system inhibitors in the management of CKD. Potassium 106-115 renin Homo sapiens 149-154 31061103-4 2019 Here, we demonstrated that HY5 directly interacts with a Reduced Potassium Dependence3/Histone Deacetylase1 (HDA1)-type histone deacetylase, HDA15, both in vitro and in vivo. Potassium 65-74 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 27-30 31061103-4 2019 Here, we demonstrated that HY5 directly interacts with a Reduced Potassium Dependence3/Histone Deacetylase1 (HDA1)-type histone deacetylase, HDA15, both in vitro and in vivo. Potassium 65-74 histone deacetylase 1 Arabidopsis thaliana 75-107 31061103-4 2019 Here, we demonstrated that HY5 directly interacts with a Reduced Potassium Dependence3/Histone Deacetylase1 (HDA1)-type histone deacetylase, HDA15, both in vitro and in vivo. Potassium 65-74 histone deacetylase 1 Arabidopsis thaliana 109-113 31061103-4 2019 Here, we demonstrated that HY5 directly interacts with a Reduced Potassium Dependence3/Histone Deacetylase1 (HDA1)-type histone deacetylase, HDA15, both in vitro and in vivo. Potassium 65-74 histone deacetylase 15 Arabidopsis thaliana 141-146 31602841-16 2019 The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver of mice were significantly enhanced in each dose group( P<0. Potassium 18-23 dynein, axonemal, heavy chain 8 Mus musculus 25-31 31297160-6 2019 Results: The plastidial expression of the KS domain could complement the defective phenotypes of a KASI knockout mutant generated by CRISPR/Cas9. Potassium 42-44 3-ketoacyl-acyl carrier protein synthase I Arabidopsis thaliana 99-103 31221261-9 2019 Lower potassium was associated with longer QT intervals (-2.8 ms; 99.75% CI: -3.5 to -2.0), JT, QRS, and PR durations, but all potassium associations were driven by use of antihypertensive drugs. Potassium 6-15 transmembrane protein 37 Homo sapiens 105-107 30997950-0 2019 Surface-Confined SnS2 @C@rGO as High-Performance Anode Materials for Sodium- and Potassium-Ion Batteries. Potassium 81-90 sodium voltage-gated channel alpha subunit 11 Homo sapiens 17-21 30965109-0 2019 ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents. Potassium 46-55 ADAM metallopeptidase domain 23 Homo sapiens 0-6 30965109-0 2019 ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents. Potassium 46-55 potassium voltage-gated channel subfamily A member 1 Homo sapiens 34-39 30965109-0 2019 ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents. Potassium 46-55 potassium voltage-gated channel subfamily A member 4 Homo sapiens 40-45 30965109-7 2019 Results Cells transfected with Kv1.1/Kv1.4 showed voltage-gated potassium currents (Kv1.1 currents). Potassium 64-73 potassium voltage-gated channel subfamily A member 1 Homo sapiens 31-36 30965109-7 2019 Results Cells transfected with Kv1.1/Kv1.4 showed voltage-gated potassium currents (Kv1.1 currents). Potassium 64-73 potassium voltage-gated channel subfamily A member 4 Homo sapiens 37-42 30965109-7 2019 Results Cells transfected with Kv1.1/Kv1.4 showed voltage-gated potassium currents (Kv1.1 currents). Potassium 64-73 potassium voltage-gated channel subfamily A member 1 Homo sapiens 84-89 30971438-3 2019 [ahx5-24]NPY also reduced tonic activation of GABAB receptors (GABABR), which increased PN excitability through inhibition of a tonic, inwardly rectifying potassium current (KIR ). Potassium 155-164 neuropeptide Y Rattus norvegicus 9-12 30936239-14 2019 Treatment with a drug that alters the voltage dependence of Kv3.1 channels normalizes the imbalance of potassium currents, as well as ABR responses in vivo, suggesting that such compounds may be effective in treating some symptoms of fragile X syndrome. Potassium 103-112 potassium voltage gated channel, Shaw-related subfamily, member 1 Mus musculus 60-65 31212818-2 2019 In addition, the selective Kv2.1 channel blocker guangxitoxin (GxTx-1E) and MiDCA1 competitively inhibited the outward potassium current in DRG neurons. Potassium 119-128 potassium voltage-gated channel subfamily B member 1 Homo sapiens 27-32 31174368-5 2019 Firstly, APP is shown to interact with and modulate the levels and activity of the neuron-specific Potassium-Chloride (K+-Cl-) cotransporter KCC2/SLC12A5. Potassium 99-108 solute carrier family 12 member 5 Homo sapiens 146-153 30945454-4 2019 In this study, we revealed that potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1) was significantly upregulated in ischemic stroke. Potassium 32-41 KCNQ1 overlapping transcript 1 Mus musculus 104-112 30831494-0 2019 Fenton-like and potassium permanganate oxidations of PAH-contaminated soils: Impact of oxidant doses on PAH and polar PAC (polycyclic aromatic compound) behavior. Potassium 16-25 phenylalanine hydroxylase Homo sapiens 53-56 29761317-7 2019 Compared with Na:Ks less than 1.0, the levels of both baPWV and cIMT were higher for participants with Na:Ks over 1.0 (baPWV: p for trend = 0.0002 for Na:Kaverage; cIMT: p for trend = 0.005 for Na:Kaverage). Potassium 106-108 CIMT Homo sapiens 64-68 31028120-6 2019 At a cellular level, Dlg1 exhibited an indispensable function to maintain membrane potential changes by securing potassium ion (K+) efflux and subsequent calcium ion (Ca2+) influx events in DCs upon stimulation, both of which are known to be required for proper function of DCs. Potassium 113-122 discs large MAGUK scaffold protein 1 Mus musculus 21-25 31053903-0 2019 Potassium Stimulation of IAA Transport Mediated by the Arabidopsis Importer AUX1 Investigated in a Heterologous Yeast System. Potassium 0-9 Transmembrane amino acid transporter family protein Arabidopsis thaliana 76-80 31016551-7 2019 Gating of P2X7 for 3 h significantly decreased intracellular ATP levels in living cells, but these had returned to normal by 20 h. P2X7-mediated ATP release was dependent on a rise in cytosolic calcium and the depletion of intracellular potassium, but was not blocked by inhibitors of pannexins or connexins. Potassium 237-246 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 10-14 31016551-7 2019 Gating of P2X7 for 3 h significantly decreased intracellular ATP levels in living cells, but these had returned to normal by 20 h. P2X7-mediated ATP release was dependent on a rise in cytosolic calcium and the depletion of intracellular potassium, but was not blocked by inhibitors of pannexins or connexins. Potassium 237-246 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 131-135 30849538-14 2019 Analysis of the Ka/Ks ratios of Cardamineae suggested positive selection exerted on the ycf2 gene in watercress, which might reflect specific adaptations of watercress to its particular living environment. Potassium 19-21 ycf2 Nasturtium officinale 88-92 31236320-3 2019 For example, the KCNQ1-KCNE1 channel produces a slowly-activating potassium current, while KCNE3 makes KCNQ1 a voltage-independent, constitutively open channel. Potassium 66-75 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 17-22 31236320-3 2019 For example, the KCNQ1-KCNE1 channel produces a slowly-activating potassium current, while KCNE3 makes KCNQ1 a voltage-independent, constitutively open channel. Potassium 66-75 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 23-28 31236320-3 2019 For example, the KCNQ1-KCNE1 channel produces a slowly-activating potassium current, while KCNE3 makes KCNQ1 a voltage-independent, constitutively open channel. Potassium 66-75 potassium voltage-gated channel subfamily E regulatory subunit 3 Homo sapiens 91-96 31236320-3 2019 For example, the KCNQ1-KCNE1 channel produces a slowly-activating potassium current, while KCNE3 makes KCNQ1 a voltage-independent, constitutively open channel. Potassium 66-75 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 103-108 31178727-0 2019 Ultrasound Stimulation Modulates Voltage-Gated Potassium Currents Associated With Action Potential Shape in Hippocampal CA1 Pyramidal Neurons. Potassium 47-56 carbonic anhydrase 1 Homo sapiens 120-123 31113422-8 2019 The detrusor strips from TREK-1 KO mice also generated more contractile force in response to electric field stimulation and high potassium concentration in comparison to WT group (p <= 0.05 for both tests). Potassium 129-138 potassium channel, subfamily K, member 2 Mus musculus 25-31 31092056-2 2019 It also, plays a significant role in the transport of calcium and potassium across the cell membranes and protects against cardiac arrhythmias and is useful for their treatment due to hypomagnesemia induced from the proton pump inhibitors (PPIs). Potassium 66-75 ATPase H+/K+ transporting subunit alpha Homo sapiens 216-227 30812034-2 2019 We tested the hypothesis of an association between the prevalence of the genotypic and allelic frequencies distribution of the potassium voltage-gated channel of the shaker related subfamily member 4 gene (KCNA4) rs1323860 (C/T transition) and endurance performance level in Hispanic male marathon runners (MR). Potassium 127-136 potassium voltage-gated channel subfamily A member 4 Homo sapiens 206-211 30758905-3 2019 CONCLUSIONS: Photosynthetic bacteria and potassium-solubilizing bacteria inoculation significantly enhanced the expression of antioxidant enzyme-related genes and increased the activities of the antioxidant enzymes superoxide dismutase, catalase and ascorbate peroxidase. Potassium 41-50 peroxidase 1 Zea mays 260-270 30910378-8 2019 We highlight GIPR, a potential diabetes drug target, as possibly implicated in the genetic control of urinary potassium excretion, and NRBP1, a locus associated with gout, as plausibly involved in sodium and albumin excretion. Potassium 110-119 gastric inhibitory polypeptide receptor Homo sapiens 13-17 30950624-0 2019 Potassium, Calcium, and Magnesium Bridging of AOT to Mica at Constant Ionic Strength. Potassium 0-9 MHC class I polypeptide-related sequence A Homo sapiens 53-57 30950624-2 2019 It was found that sodium ions did not show any bridging effect in this system; however, calcium, magnesium, and potassium all caused adsorption of the organic to the mica surface. Potassium 112-121 MHC class I polypeptide-related sequence A Homo sapiens 166-170 31024004-0 2019 RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Potassium 95-104 NLR family pyrin domain containing 3 Homo sapiens 38-43 31024004-4 2019 Here, we report that the replication of cytopathogenic RNA viruses such as vesicular stomatitis virus (VSV) or encephalomyocarditis virus (EMCV) induced a lytic cell death leading to potassium efflux, the common trigger of NLRP3 inflammasome activation. Potassium 183-192 NLR family pyrin domain containing 3 Homo sapiens 223-228 31017964-6 2019 The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. Potassium 77-86 ETS transcription factor ERG Homo sapiens 72-76 30784151-1 2019 The first main-group element radical based one-dimensional magnetic chain (1K)n was realized by one-electron reduction of the pyridinyl functionalized borane 1 with elemental potassium in THF in the absence of 18-crown-6 (18-c-6). Potassium 175-184 complement C6 Homo sapiens 225-228 30784151-4 2019 In contrast, the reduction in the presence of 18-c-6 afforded the separated radical anion salt 1K(Crown), in which the potassium cation was trapped by THF and 18-c-6 molecules. Potassium 119-128 complement C6 Homo sapiens 49-52 30784151-4 2019 In contrast, the reduction in the presence of 18-c-6 afforded the separated radical anion salt 1K(Crown), in which the potassium cation was trapped by THF and 18-c-6 molecules. Potassium 119-128 complement C6 Homo sapiens 162-165 31044010-0 2019 Evolutionary engineering in Saccharomyces cerevisiae reveals a TRK1-dependent potassium influx mechanism for propionic acid tolerance. Potassium 78-87 Trk1p Saccharomyces cerevisiae S288C 63-67 31044010-6 2019 Potassium supplementation growth assays showed that mutated TRK1 alleles and extracellular potassium supplementation not only conferred tolerance to PA stress but also to multiple organic acids. Potassium 0-9 Trk1p Saccharomyces cerevisiae S288C 60-64 30967508-1 2019 Membrane depolarization and intracellular Ca2+ promote activation of the large-conductance Ca2+- and voltage-gated (Slo1) big potassium (BK) channel. Potassium 126-135 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 116-120 31013253-0 2019 Potassium acts through mTOR to regulate its own secretion. Potassium 0-9 mechanistic target of rapamycin kinase Homo sapiens 23-27 30918124-2 2019 The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I Ks complex to open the pore is controversial. Potassium 153-155 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 53-58 32884994-5 2020 In cells transiently transfected with ubiquitin (UB) constructs contained different lysine residues (Ks), Vps34 ubiquitination could occur regardless of the presence of any Ks in UB. Potassium 101-103 phosphatidylinositol 3-kinase catalytic subunit type 3 Mus musculus 106-111 30689740-3 2019 The generally accepted common mechanism whereby drugs prolong QT is block of a key repolarizing potassium current in heart, IKr, generated by expression of KCNH2, also known as HERG. Potassium 96-105 potassium voltage-gated channel subfamily H member 2 Homo sapiens 156-161 30689740-3 2019 The generally accepted common mechanism whereby drugs prolong QT is block of a key repolarizing potassium current in heart, IKr, generated by expression of KCNH2, also known as HERG. Potassium 96-105 potassium voltage-gated channel subfamily H member 2 Homo sapiens 177-181 30816699-6 2019 For kappa-carrageenan in the presence of potassium, a disorder-order transition from random coil to single helix is first observed (secondary structure), followed by intrachain supercoiling events (tertiary structure) and macroscopic anisotropic domains which are parts of a network (quaternary structure) with tunable elasticity up to ~103 Pa. Potassium 41-50 coilin Homo sapiens 92-96 31001573-4 2019 Given insulin to these patients immediately can lead to further decrease in extracellular potassium level and lead to cardiac dysrhythmias and death. Potassium 90-99 insulin Homo sapiens 6-13 31093276-6 2019 In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Potassium 111-120 surfactant protein C Rattus norvegicus 12-15 31043849-4 2019 Ka/Ks ratios analyses of protein-coding genes revealed that the highest and lowest rates were found in ND6 and COI and that all these genes were evolving under purifying selection. Potassium 3-5 mitochondrially encoded NADH dehydrogenase 6 Homo sapiens 103-106 30835490-6 2019 We reproduced key electrophysiological and pharmacological features known for native IK1, including current enhancement by external potassium and voltage- and concentration-dependent blockade by external barium. Potassium 132-141 IKAROS family zinc finger 1 Homo sapiens 85-88 29968124-6 2019 Potassium was significantly higher in milk from Nitra region (3301.98 +- 95.66) against SK sample (2925.16 +- 75.74 mug/mL). Potassium 0-9 Weaning weight-maternal milk Bos taurus 38-42 30792104-2 2019 Additionally, inhibition of potassium current through the cardiac hERG channel by bedaquiline, is associated with prolongation of the QT interval, necessitating cardiovascular monitoring. Potassium 28-37 ETS transcription factor ERG Homo sapiens 66-70 30888091-2 2019 Furthermore, SIMesPK was used in reactions with potassium amides and alkoxides to form the molecular phosphorus-potassium clusters [K4 (SIMesP)2 (hmds)2 ] [5, hmds=N(SiMe3 )2 ] and [K6 (SIMesP)2 (OtBu)4 ] (6). Potassium 48-57 keratin 4 Homo sapiens 132-144 30918124-2 2019 The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I Ks complex to open the pore is controversial. Potassium 153-155 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 82-87 31344212-1 2019 The renin-angiotensin-aldosterone system modulates volume, sodium and potassium homeostasis. Potassium 70-79 renin Homo sapiens 4-9 30659840-0 2019 cAMP-producing chemogenetic and adenosine A2a receptor activation inhibits the inwardly rectifying potassium current in striatal projection neurons. Potassium 99-108 adenosine A2a receptor Homo sapiens 32-54 30909873-9 2019 In multivariable linear regression analysis, the urinary AGT/creatinine (Cr) ratio was negatively correlated with the serum potassium level (beta = - 0.058, P = 0.017) and positively correlated with the transtubular potassium gradient (TTKG, beta = 0.087, P = 0.001). Potassium 124-133 angiotensinogen Homo sapiens 57-60 30909873-9 2019 In multivariable linear regression analysis, the urinary AGT/creatinine (Cr) ratio was negatively correlated with the serum potassium level (beta = - 0.058, P = 0.017) and positively correlated with the transtubular potassium gradient (TTKG, beta = 0.087, P = 0.001). Potassium 216-225 angiotensinogen Homo sapiens 57-60 30967788-2 2019 LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (I Ks), which is essential for cardiac repolarization. Potassium 93-102 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-4 30967788-2 2019 LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (I Ks), which is essential for cardiac repolarization. Potassium 93-102 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 49-54 30967788-2 2019 LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (I Ks), which is essential for cardiac repolarization. Potassium 114-116 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-4 30967788-2 2019 LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (I Ks), which is essential for cardiac repolarization. Potassium 114-116 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 49-54 30850693-2 2019 The structure of a putative G-quadruplex sequence (S1: GGAGAAGGAGGAGGTGGAGGAGGAGGG) in potassium solution in the her2 promoter has been resolved mainly through nuclear magnetic resonance (NMR) spectroscopy. Potassium 87-96 erb-b2 receptor tyrosine kinase 2 Homo sapiens 113-117 30909873-0 2019 Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study. Potassium 49-58 angiotensinogen Homo sapiens 8-23 30765526-10 2019 The results provide compelling support for the notion that WNK4 is a bona fide physiological intracellular Cl- sensor and that Cl- regulation of WNK4 underlies the mechanism of regulation of NCC by extracellular potassium. Potassium 212-221 WNK lysine deficient protein kinase 4 Mus musculus 145-149 30482581-8 2019 Awareness of this association between claudin 10 mutations and electrolyte abnormalities, namely hypokalemia and hypermagnesemia, sheds new light on the physiology of potassium and magnesium handling along the nephron and increases the likelihood of identifying the underlying tubular mechanism in patients with newly diagnosed hypokalemia with or without concomitant hypermagnesemia. Potassium 167-176 claudin 10 Homo sapiens 38-48 29976269-3 2019 The milk concentration of calcium (Ca), potassium (K), magnesium (Mg), sodium (Na) and phosphorus (P) in the present study was quantified from mid-IR spectroscopy on 12 223 test-day records from 1717 Holstein-Friesian cows. Potassium 40-49 Weaning weight-maternal milk Bos taurus 4-8 32626251-1 2019 In this opinion, the EFSA Panel on Food Additives and Flavourings (FAF Panel) was requested by the European Commission to carry out a scientific evaluation of an extended one-generation reproductive toxicity study (EOGRTS) to determine whether it would allow reconsideration of the temporary group acceptable daily intake (ADI) for sorbic acid (E 200) and potassium sorbate (E 202), established by the Panel on Food Additives and Nutrient Sources added to Food (ANS Panel) in 2015. Potassium 356-365 ubiquitin specific peptidase 9 X-linked Homo sapiens 67-70 30623727-4 2019 The alteration of basolateral potassium conductance is essential for the effect of dietary K+ intake on NCC because deletion of Kir4.1 in the DCT abolished the effect of dietary K+ intake on NCC. Potassium 30-39 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 128-134 30623727-5 2019 Since potassium intake-mediated regulation of NCC plays a key role in regulating renal K+ excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K+ intake. Potassium 6-15 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 143-149 30623727-5 2019 Since potassium intake-mediated regulation of NCC plays a key role in regulating renal K+ excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K+ intake. Potassium 104-113 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 143-149 30595123-4 2019 Several studies have found that the mTORC2 pathway is involved in the regulation of renal tubular sodium and potassium transport, but its role in hypertension has remained largely unexplored. Potassium 109-118 CREB regulated transcription coactivator 2 Mus musculus 36-42 30731085-1 2019 Cardiac sodium (Na+) potassium ATPase (NaK) pumps, neuronal sodium channels (INa), and sodium calcium (Ca2+) exchangers (NCX1) may co-localize to form a Na+ microdomain. Potassium 21-30 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 77-80 29083247-1 2019 The potassium ion, K+, a neuronal signal that is released during excitatory synaptic activity, produces acute activation of glucose consumption in cultured astrocytes, a phenomenon mediated by the sodium bicarbonate cotransporter NBCe1 ( SLC4A4). Potassium 4-13 solute carrier family 4 (anion exchanger), member 4 Mus musculus 238-244 30813600-1 2019 The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Potassium 50-59 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 61-69 30556625-3 2019 The crown-ether complexes of sodium (1-Na) and potassium (1-K) exhibited different structures, with sodium preferring coordination to the nitrogen end, whereas potassium binds in an unusual eta2 -coordination mode to the two central carbon atoms. Potassium 47-56 DNA polymerase iota Homo sapiens 190-194 30556625-3 2019 The crown-ether complexes of sodium (1-Na) and potassium (1-K) exhibited different structures, with sodium preferring coordination to the nitrogen end, whereas potassium binds in an unusual eta2 -coordination mode to the two central carbon atoms. Potassium 160-169 DNA polymerase iota Homo sapiens 190-194 30787866-1 2019 Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (I A). Potassium 180-189 potassium voltage-gated channel interacting protein 3 Rattus norvegicus 0-50 30787866-1 2019 Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (I A). Potassium 180-189 potassium voltage-gated channel interacting protein 3 Rattus norvegicus 52-57 30787866-1 2019 Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (I A). Potassium 180-189 potassium voltage-gated channel interacting protein 3 Rattus norvegicus 59-65 30787866-1 2019 Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (I A). Potassium 180-189 potassium voltage-gated channel interacting protein 3 Rattus norvegicus 66-76 29861377-2 2019 The goals of this study were to describe the frequency of hypoglycemia following the use of insulin to shift potassium intracellularly and to examine the association of key variables with this complication. Potassium 109-118 insulin Homo sapiens 92-99 30520694-17 2019 Both hormones require PAK4 activation to stimulate sodium-potassium adenosine triphosphatase activity. Potassium 58-67 p21 (RAC1) activated kinase 4 Rattus norvegicus 22-26 30731085-1 2019 Cardiac sodium (Na+) potassium ATPase (NaK) pumps, neuronal sodium channels (INa), and sodium calcium (Ca2+) exchangers (NCX1) may co-localize to form a Na+ microdomain. Potassium 21-30 solute carrier family 8 member A1 Canis lupus familiaris 121-125 30289750-2 2019 Human KCNE5 mutations are associated with atrial fibrillation (AF)- and Brugada syndrome (BrS)-induced cardiac arrhythmias that can arise from increased potassium current in cardiomyocytes. Potassium 153-162 potassium voltage-gated channel subfamily E regulatory subunit 5 Homo sapiens 6-11 30172029-12 2019 CONCLUSION: This CACNA1C-E1115K variant destroyed the LTCC"s calcium selectivity and instead converted the mutant channel into a channel with a marked increase in sodium-mediated inward currents and potassium-mediated outward currents. Potassium 199-208 calcium voltage-gated channel subunit alpha1 C Homo sapiens 17-24 29447615-4 2019 In this work, we explored the structural role of potassium ions in Site 1 and Site 2 and how they affect the interactions of compounds with high affinities for HDAC1 (AC1OCG0B, Chlamydocin, Dacinostat and Quisinostat) and SAHA (a pan-inhibitor) using molecular docking and molecular dynamics (MD) simulations in concert with a Molecular-Mechanics-Generalized-Born-Surface-Area (MMGBSA) approach. Potassium 49-58 histone deacetylase 1 Homo sapiens 160-165 30159893-2 2019 As the key regulator of tumor cell volume, sodium-potassium-chloride cotransporter 1 (NKCC1) expression increases along with the malignancy of the glioma, and NKCC1 has been implicated in glioblastoma invasion. Potassium 50-59 solute carrier family 12, member 2 Mus musculus 86-91 30847194-2 2019 The immune phenotyping of the circulating FOXP3+ naive Treg populations in KS patients may help to indicate this predisposition. Potassium 75-77 forkhead box P3 Homo sapiens 42-47 30611209-0 2019 Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons. Potassium 69-78 carbonic anhydrase 1 Rattus norvegicus 107-110 30740538-5 2019 Intracellular acidification, by inhibiting glycolysis, works together with mitochondrial inhibition to induce intracellular ATP loss, which compromises intracellular potassium maintenance, a key event to NLRP3 inflammasome activation. Potassium 166-175 NLR family pyrin domain containing 3 Homo sapiens 204-209 30740538-7 2019 Our work illustrates how energy metabolism converges upon intracellular potassium to activate NLRP3 inflammasome and highlights a biphasic relationship between cellular physiology and IL-1beta release. Potassium 72-81 NLR family pyrin domain containing 3 Homo sapiens 94-99 30605673-0 2019 Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current. Potassium 102-111 heat shock protein family A (Hsp70) member 4 Homo sapiens 14-19 30605673-4 2019 Hsp70 expression is upregulated in a KA model of TLE, and silencing or inhibition of Hsp70 suppresses neuronal hyperexcitability and attenuates acute or chronic epilepsy by enhancing A-type potassium current in hippocampal neurons. Potassium 190-199 heat shock protein family A (Hsp70) member 4 Homo sapiens 85-90 30389838-2 2019 Here we report a major role of voltage-independent potassium (K+)-channel dysfunction in hyperexcitability of CA3 pyramidal neurons in Fmr1 knock-out (KO) mice. Potassium 51-60 carbonic anhydrase 3 Mus musculus 110-113 30389838-2 2019 Here we report a major role of voltage-independent potassium (K+)-channel dysfunction in hyperexcitability of CA3 pyramidal neurons in Fmr1 knock-out (KO) mice. Potassium 51-60 fragile X messenger ribonucleoprotein 1 Mus musculus 135-139 31114435-10 2019 In the subgroup of children with normal bladder capacity a trend towards a positive correlation between copeptin and potassium was found. Potassium 117-126 arginine vasopressin Homo sapiens 104-112 30604490-2 2019 Reactions of lithium or potassium salts of a variety of beta-diketiminates have given both three-coordinate complexes, [{HC(RCNAr)2 }BeX] (R=H or Me; Ar=Mes, Dep or Dip; X=Br or I); and four-coordinate systems, [{HC(MeCNPh)2 }BeBr(OEt2 )] and [{HC(MeCNDip)(MeCNC2 H4 NMe2 }BeI]. Potassium 24-33 brain expressed X-linked 3 Homo sapiens 133-136 31583586-5 2019 NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation. Potassium 63-72 chondroitin sulfate proteoglycan 4 Homo sapiens 0-3 31583586-5 2019 NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation. Potassium 274-283 chondroitin sulfate proteoglycan 4 Homo sapiens 0-3 31583586-5 2019 NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation. Potassium 274-283 chondroitin sulfate proteoglycan 4 Homo sapiens 125-128 30589965-3 2019 A new potassium-competitive acid blocker (P-CAB) can rapidly block acid secretion. Potassium 6-15 neural proliferation, differentiation and control 1 Homo sapiens 44-47 30089030-2 2019 NCC activity is critical for modulation of arterial blood pressure and serum potassium levels. Potassium 77-86 solute carrier family 12, member 3 Mus musculus 0-3 31192570-12 2019 In a multivariate analysis model, serum potassium (beta=1.41, p=0.010), male sex (beta=2.15, p=0.003), and HGS (beta=-0.088, p=0.021) were found as independent predictors of sleep quality. Potassium 40-49 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 51-57 31114435-12 2019 The relation between potassium and copeptin levels and the clinical significance of the relation require further studies. Potassium 21-30 arginine vasopressin Homo sapiens 35-43 31854954-1 2019 Kv1.3 is a voltage gated potassium channel located in the plasma membrane, as well as at intracellular levels, such as mitochondria (mitoKv1.3), nucleus and Golgi apparatus. Potassium 25-34 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 0-5 30306852-6 2019 More specifically, GSK-3beta-sensitive cellular transport regulation involves various calcium, chloride, sodium, and potassium ion channels, as well as a number of Na+-coupled cellular carriers including excitatory amino acid transporters EAAT2, 3 and 4, high-affinity Na+ coupled glucose carriers SGLT1, creatine transporter 1 CreaT1, and the type II sodium/phosphate cotransporter NaPi-IIa. Potassium 117-126 glycogen synthase kinase 3 alpha Homo sapiens 19-28 29588531-2 2019 Kidney dysfunction and renin-angiotensin-aldosterone system inhibiting drugs are notorious for their tendency to induce hyperkalemia by decreasing the excretion of potassium. Potassium 164-173 renin Homo sapiens 23-28 31588541-13 2019 Most commonly, neonatal diabetes is caused by mutations in KCNJ11 and ABCC8 genes encoding the ATP-dependent potassium channel of the beta cell. Potassium 109-118 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 59-65 31588541-13 2019 Most commonly, neonatal diabetes is caused by mutations in KCNJ11 and ABCC8 genes encoding the ATP-dependent potassium channel of the beta cell. Potassium 109-118 ATP binding cassette subfamily C member 8 Homo sapiens 70-75 31654968-9 2019 DISCUSSION: AKAP9 is a scaffolding protein that facilitates phosphorylation of delayed-rectifier potassium channels. Potassium 97-106 A-kinase anchoring protein 9 Homo sapiens 12-17 30391945-4 2019 Using inhibitor-based approaches, we show that NLRP3 activation by T. vaginalis involves host cell detection of extracellular ATP via P2X7 receptors and potassium efflux. Potassium 153-162 NLR family pyrin domain containing 3 Homo sapiens 47-52 30561082-0 2019 Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor. Potassium 53-62 potassium inwardly rectifying channel subfamily J member 13 Homo sapiens 80-86 30348896-8 2019 Glutamate, potassium, and DL-threo-beta-benzyloxyaspartate facilitated crosslinking in the A243C/T396C transporter and this suggests that the TM4b-4c loop and beta-bridge region in TM7 were drawn into close proximity to each other in the inward- and outward-facing conformation of EAAT1. Potassium 11-20 tetraspanin 16 Homo sapiens 142-146 30348896-8 2019 Glutamate, potassium, and DL-threo-beta-benzyloxyaspartate facilitated crosslinking in the A243C/T396C transporter and this suggests that the TM4b-4c loop and beta-bridge region in TM7 were drawn into close proximity to each other in the inward- and outward-facing conformation of EAAT1. Potassium 11-20 solute carrier family 1 member 3 Homo sapiens 281-286 30868936-0 2019 Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model. Potassium 104-113 glial cell derived neurotrophic factor Rattus norvegicus 7-50 30868936-0 2019 Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model. Potassium 104-113 potassium voltage-gated channel subfamily D member 1 Rattus norvegicus 82-87 30868936-3 2019 The fast-inactivating transient A-type potassium current (IA) is an important determinant of neuronal excitability, and five voltage-gated potassium channel (Kv) alpha-subunits, Kv1.4, Kv3.4, Kv4.1, Kv4.2, and Kv4.3, display IA in heterologous expression systems. Potassium 39-48 potassium voltage-gated channel subfamily A member 4 Rattus norvegicus 178-183 30868936-3 2019 The fast-inactivating transient A-type potassium current (IA) is an important determinant of neuronal excitability, and five voltage-gated potassium channel (Kv) alpha-subunits, Kv1.4, Kv3.4, Kv4.1, Kv4.2, and Kv4.3, display IA in heterologous expression systems. Potassium 39-48 potassium voltage-gated channel subfamily D member 1 Rattus norvegicus 192-197 30868936-3 2019 The fast-inactivating transient A-type potassium current (IA) is an important determinant of neuronal excitability, and five voltage-gated potassium channel (Kv) alpha-subunits, Kv1.4, Kv3.4, Kv4.1, Kv4.2, and Kv4.3, display IA in heterologous expression systems. Potassium 39-48 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 199-204 30868936-3 2019 The fast-inactivating transient A-type potassium current (IA) is an important determinant of neuronal excitability, and five voltage-gated potassium channel (Kv) alpha-subunits, Kv1.4, Kv3.4, Kv4.1, Kv4.2, and Kv4.3, display IA in heterologous expression systems. Potassium 39-48 potassium voltage-gated channel subfamily D member 3 Rattus norvegicus 210-215 29982819-2 2019 Aldosterone stimulates the collecting duct mineralocorticoid receptor (MR) to upregulate the epithelial sodium channel (ENaC) and stimulate electrogenic sodium reabsorption, with secretion of potassium and protons. Potassium 192-201 nuclear receptor subfamily 3 group C member 2 Homo sapiens 43-69 29982819-2 2019 Aldosterone stimulates the collecting duct mineralocorticoid receptor (MR) to upregulate the epithelial sodium channel (ENaC) and stimulate electrogenic sodium reabsorption, with secretion of potassium and protons. Potassium 192-201 nuclear receptor subfamily 3 group C member 2 Homo sapiens 71-73 30540522-2 2019 Recently, we have shown that potassium influx through a potassium channel complex AKT1-KC1 is inhibited by cesium in Arabidopsis thaliana and the resultant reduction in potassium accumulation in the plant is the primary cause of retarded growth. Potassium 29-38 K+ transporter 1 Arabidopsis thaliana 82-86 30540522-2 2019 Recently, we have shown that potassium influx through a potassium channel complex AKT1-KC1 is inhibited by cesium in Arabidopsis thaliana and the resultant reduction in potassium accumulation in the plant is the primary cause of retarded growth. Potassium 29-38 potassium channel protein Arabidopsis thaliana 87-90 30540522-2 2019 Recently, we have shown that potassium influx through a potassium channel complex AKT1-KC1 is inhibited by cesium in Arabidopsis thaliana and the resultant reduction in potassium accumulation in the plant is the primary cause of retarded growth. Potassium 56-65 K+ transporter 1 Arabidopsis thaliana 82-86 30540522-2 2019 Recently, we have shown that potassium influx through a potassium channel complex AKT1-KC1 is inhibited by cesium in Arabidopsis thaliana and the resultant reduction in potassium accumulation in the plant is the primary cause of retarded growth. Potassium 56-65 potassium channel protein Arabidopsis thaliana 87-90 30540522-3 2019 By contrast, a major potassium transporter, HAK5 whose function is crucial under potassium deficiency, was found to be either not affected or complementary under cesium stress in the low affinity potassium range. Potassium 21-30 high affinity K+ transporter 5 Arabidopsis thaliana 44-48 30540522-3 2019 By contrast, a major potassium transporter, HAK5 whose function is crucial under potassium deficiency, was found to be either not affected or complementary under cesium stress in the low affinity potassium range. Potassium 81-90 high affinity K+ transporter 5 Arabidopsis thaliana 44-48 31621014-2 2019 Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Potassium 27-36 ETS transcription factor ERG Homo sapiens 22-26 31787649-9 2019 Thus, careful monitoring of potassium levels in patients treated with TAZ/PIPC, particularly those aged >81 years, is warranted. Potassium 28-37 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 70-73 30591705-1 2018 The mineralocorticoid receptor (MR) in mammals mediates the effects of aldosterone in regulating fluid balance and potassium homeostasis. Potassium 115-124 nuclear receptor subfamily 3, group C, member 2 Danio rerio 4-30 30591705-1 2018 The mineralocorticoid receptor (MR) in mammals mediates the effects of aldosterone in regulating fluid balance and potassium homeostasis. Potassium 115-124 nuclear receptor subfamily 3, group C, member 2 Danio rerio 32-34 30618766-6 2018 Therefore, here we investigated effects of the selective mu-opioid receptor (MOR) agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO) on potassium conductance in DRG neurons upon a chronic constriction injury (CCI) of the sciatic nerve in mice. Potassium 141-150 opioid receptor, mu 1 Mus musculus 57-75 30618766-13 2018 A comparative analysis of opioid-induced potassium conductance at the axonal injury site and peripheral terminals of DRG neurons could clarify the role of Kir3 channel-MOR interactions in peripheral nerve injury and opioid analgesia. Potassium 41-50 opioid receptor, mu 1 Mus musculus 168-171 30412386-8 2018 Kinetic analyses using recombinant proteins revealed that CYP2C9 variants (A82V and H344R) showed substantially lower Ks values than the wild type, although CYP1A1 variant (V382I) showed kinetic parameters similar to the wild type. Potassium 119-121 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 58-64 30647796-7 2018 In age-adjusted analyses, salivary potassium was significantly associated with carotid artery intima media thickness (cIMT) and carotid-femoral pulse wave velocity, and these associations were at the limit of significance in multivariate analyses including prevalent cardiovascular disease and risk factors. Potassium 35-44 CIMT Homo sapiens 118-122 29932955-4 2018 Lysosomal destabilization, efflux of cytosolic potassium ions and influx of calcium ions, signals from damaged mitochondria, both translational and post-translational controls, and prion-like polymerization have increasingly clear roles in regulating NLRP3 activation. Potassium 47-56 NLR family pyrin domain containing 3 Homo sapiens 251-256 29981989-7 2018 The magnitude of Ks provides an idea about the bioavailable fraction of PCBs in the system; the higher the Ks, the greater the strength of sorption by the sorbent and therefore, the lower the PCB bioavailability. Potassium 17-19 pyruvate carboxylase Homo sapiens 72-75 29981989-7 2018 The magnitude of Ks provides an idea about the bioavailable fraction of PCBs in the system; the higher the Ks, the greater the strength of sorption by the sorbent and therefore, the lower the PCB bioavailability. Potassium 107-109 pyruvate carboxylase Homo sapiens 72-75 30532259-7 2018 The crystal structure of the HDAC3:SMRT complex possesses two monovalent cations (MVCs) labeled as potassium with one MVC binding site near the active site Zn(II) and the second MVC binding site >=20 A from the active site Zn(II). Potassium 99-108 histone deacetylase 3 Apis mellifera 29-34 30532259-9 2018 We also report the effects of varying concentrations of potassium ions where [K+] up to 10 mM increase HDAC3 activity with a maximum kcat/KM of approximately 80,000 M-1s-1 while [K+] above 10 mM inhibit HDAC3 activity. Potassium 56-65 histone deacetylase 3 Apis mellifera 103-108 30532259-9 2018 We also report the effects of varying concentrations of potassium ions where [K+] up to 10 mM increase HDAC3 activity with a maximum kcat/KM of approximately 80,000 M-1s-1 while [K+] above 10 mM inhibit HDAC3 activity. Potassium 56-65 histone deacetylase 3 Apis mellifera 203-208 30532259-11 2018 The regulatory effects of zinc, potassium, and 10-HDA concentration on HDAC3 activity suggest a strong correlation between these chemical species and epigenetic control over Apis mellifera caste differentiation among other control mechanisms. Potassium 32-41 histone deacetylase 3 Apis mellifera 71-76 30517856-4 2018 We show that dietary potassium restriction leads promptly to proliferation of various nephron segments, including the distal convoluted tubule, whereas disruption of the potassium sensor Kir4.1 causes atrophy, despite ambient hypokalemia. Potassium 170-179 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 187-193 30218483-8 2018 In retinal arteries, NPY-induced vasoconstriction to a plateau of approximately 65% of potassium-induced constriction. Potassium 87-96 neuropeptide Y Sus scrofa 21-24 30266221-5 2018 Based on isotopic measurements, Edelman showed SNa level to be a function of exchangeable sodium and potassium divided by total-body water. Potassium 101-110 snail family transcriptional repressor 1 Homo sapiens 47-50 30323262-2 2018 The inwardly rectifying potassium channel (Kir) is a potassium-selective ion channel that allows potassium ions to move more easily into rather than out of the cell. Potassium 24-33 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 43-46 30145795-0 2018 Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway. Potassium 66-75 microRNA 200c Rattus norvegicus 98-106 30145795-0 2018 Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway. Potassium 66-75 high mobility group box 1 Rattus norvegicus 107-112 31654968-10 2019 The AKAP9 variant alters potassium current causing disordered repolarization and ventricular reentry. Potassium 25-34 A-kinase anchoring protein 9 Homo sapiens 4-9 30063108-7 2018 In contrast, a negative correlation was found between S100A12 and the potassium concentration and pH of milk. Potassium 70-79 S100 calcium binding protein A12 Bos taurus 54-61 30109784-7 2018 Compared with the control group, Ca-PS treatment significantly reduced serum potassium levels (P <0.01). Potassium 77-86 calcyphosine Homo sapiens 33-38 30109784-8 2018 More patients in the Ca-PS group had lower serum potassium levels than the safety level of <5.5 mmol/L (32% for control vs. 61% for Ca-PS, P <0.01). Potassium 49-58 calcyphosine Homo sapiens 21-26 30109784-11 2018 Ca-PS treatment decreases serum levels of potassium and phosphorus in MHD patients with interdialytic hyperkalemia. Potassium 42-51 calcyphosine Homo sapiens 0-5 30485804-3 2018 Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux. Potassium 143-152 BCL2 associated X, apoptosis regulator Homo sapiens 13-16 30485804-3 2018 Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux. Potassium 143-152 BCL2 antagonist/killer 1 Homo sapiens 17-20 30485804-3 2018 Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux. Potassium 143-152 NLR family pyrin domain containing 3 Homo sapiens 61-66 30485804-3 2018 Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux. Potassium 143-152 caspase 1 Homo sapiens 89-98 30485804-3 2018 Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux. Potassium 143-152 interleukin 1 alpha Homo sapiens 109-117 30092543-5 2018 PM2.5 could be internalized into cells through multiple endocytosis processes, such as phagocytosis and pinocytosis (macropinocytosis, clathrin- and caveolin-mediated endocytosis), and activate NLRP3 inflammasome through cathepsin B release, ROS production, and potassium efflux. Potassium 262-271 NLR family, pyrin domain containing 3 Mus musculus 194-199 30441852-15 2018 Cardiac targeting peptide appears to utilize Kcnh5 to gain cell entry, a phenomenon that is affected by pre-treatment with Quinidine and changes in potassium levels. Potassium 148-157 potassium voltage-gated channel subfamily H member 5 Homo sapiens 45-50 30473666-2 2018 Our lab has recently explored this sub-cellular microdomain and found that potassium inward rectifier Kir2.x is found in association with caveolin-3. Potassium 75-84 caveolin 3 Homo sapiens 138-148 30110571-0 2018 Potassium conservation is impaired in mice with reduced renal expression of Kir4.1. Potassium 0-9 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 76-82 30096351-8 2018 Moreover, NLRP1 but not NLRP3 was required for inflammasome activation in response to nigericin, a potassium ionophore and well-established NLRP3 activator in immune cells. Potassium 99-108 NLR family pyrin domain containing 1 Homo sapiens 10-15 29553285-6 2018 These data suggest weight-based insulin dosing is equally effective for lowering serum potassium and may lower risk of severe hypoglycemia. Potassium 87-96 insulin Homo sapiens 32-39 30571183-7 2018 The mutant Kv4.2 exhibited impaired response to PKC; hence, Kv4.2 membrane expression was augmented, enhancing potassium currents. Potassium 111-120 potassium voltage-gated channel subfamily D member 2 Homo sapiens 11-16 30571183-7 2018 The mutant Kv4.2 exhibited impaired response to PKC; hence, Kv4.2 membrane expression was augmented, enhancing potassium currents. Potassium 111-120 potassium voltage-gated channel subfamily D member 2 Homo sapiens 60-65 30107592-4 2018 Here, we expanded the mutation spectrum of KMT2D and KDM6A in KS by identifying 37 new KMT2D sequence variants. Potassium 62-64 lysine methyltransferase 2D Homo sapiens 43-48 30107592-4 2018 Here, we expanded the mutation spectrum of KMT2D and KDM6A in KS by identifying 37 new KMT2D sequence variants. Potassium 62-64 lysine demethylase 6A Homo sapiens 53-58 30107592-4 2018 Here, we expanded the mutation spectrum of KMT2D and KDM6A in KS by identifying 37 new KMT2D sequence variants. Potassium 62-64 lysine methyltransferase 2D Homo sapiens 87-92 30766810-1 2018 Parathyroid hormone (PTH) is the main regulator of calcium, phosphate, magnesium, sodium, and potassium homeostasis. Potassium 94-103 parathyroid hormone Homo sapiens 0-19 30766810-1 2018 Parathyroid hormone (PTH) is the main regulator of calcium, phosphate, magnesium, sodium, and potassium homeostasis. Potassium 94-103 parathyroid hormone Homo sapiens 21-24 30160358-10 2018 Co-expression of KCND3/WT and SCN1Bbeta/S248R or SCN1Bbeta/R250T increased the transient outward potassium current Ito by 27.44% and 199.89%, respectively (P < 0.05 and P < 0.01, respectively) when compared with SCN1Bbeta/WT. Potassium 97-106 potassium voltage-gated channel subfamily D member 3 Homo sapiens 17-22 30190339-2 2018 As oxidative injury leads to the intracellular liberation of zinc, we hypothesize that tapping onto the zinc-activated metal regulatory element (MRE) transcription factor 1 system to drive expression of the Kv2.1-targeted hepatitis C protein NS5A (hepatitis C nonstructural protein 5A) will provide neuroprotection by preventing cell death-enabling cellular potassium loss in rat cortical neurons in vitro. Potassium 358-367 potassium voltage-gated channel subfamily B member 1 Homo sapiens 207-212 30190339-4 2018 Further, we report that MRE-driven NS5A expression, induced by a slowly evolving excitotoxic stimulus, functionally blocks injurious, enhanced Kv2.1 potassium whole-cell currents and improves neuronal viability. Potassium 149-158 potassium voltage-gated channel subfamily B member 1 Homo sapiens 143-148 29582401-2 2018 TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. Potassium 138-147 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 30416361-7 2018 The applied melatonin prevented potassium and intracellular enzyme leakage (CK and LDH) that was induced by CCl4, as well as an increase in tissue MDA. Potassium 32-41 C-C motif chemokine ligand 4 Rattus norvegicus 108-112 30296052-2 2018 To address these limitations, we developed a novel kappa-carrageenan/polyacrylamide (KC/PAM) DN hydrogel through a dual physical-cross-linking strategy, with the ductile, hydrophobically associated PAM being the first network, and the rigid potassium ion (K+) cross-linked KC being the second network. Potassium 241-250 peptidylglycine alpha-amidating monooxygenase Homo sapiens 198-201 30380640-9 2018 However, administration of aloin suppressed liver injury as well as Muller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Muller cells. Potassium 176-185 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 118-124 30380640-9 2018 However, administration of aloin suppressed liver injury as well as Muller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Muller cells. Potassium 176-185 aquaporin 4 Rattus norvegicus 129-140 30405539-2 2018 In Saccharomyces cerevisiae, the serine/threonine (S/T) kinase Sat4/Hal4 is required for potassium accumulation, and thus, regulates the resistance to sodium salts and helps in the stabilization of other plasma membrane transporters. Potassium 89-98 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 63-67 30405539-2 2018 In Saccharomyces cerevisiae, the serine/threonine (S/T) kinase Sat4/Hal4 is required for potassium accumulation, and thus, regulates the resistance to sodium salts and helps in the stabilization of other plasma membrane transporters. Potassium 89-98 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 68-72 30356026-3 2018 Inwardly rectifying potassium (Kir) channel subunit Kir4.1, which is specifically expressed in astrocytes, constructs Kir4.1 and Kir4.1/5.1 channels, and mediates the spatial potassium (K+) buffering action of astrocytes. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 31-34 30356026-3 2018 Inwardly rectifying potassium (Kir) channel subunit Kir4.1, which is specifically expressed in astrocytes, constructs Kir4.1 and Kir4.1/5.1 channels, and mediates the spatial potassium (K+) buffering action of astrocytes. Potassium 20-29 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 52-58 30356026-3 2018 Inwardly rectifying potassium (Kir) channel subunit Kir4.1, which is specifically expressed in astrocytes, constructs Kir4.1 and Kir4.1/5.1 channels, and mediates the spatial potassium (K+) buffering action of astrocytes. Potassium 20-29 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 118-124 30356026-3 2018 Inwardly rectifying potassium (Kir) channel subunit Kir4.1, which is specifically expressed in astrocytes, constructs Kir4.1 and Kir4.1/5.1 channels, and mediates the spatial potassium (K+) buffering action of astrocytes. Potassium 20-29 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 118-124 30353147-4 2018 Using our TPA model, we have demonstrated that spontaneous diastolic depolarization observed in atrial myocytes with TBX5-deletion can be explained by altered intracellular calcium handling and suppression of inward-rectifier potassium current (IK1). Potassium 226-235 T-box transcription factor 5 Homo sapiens 117-121 30341287-3 2018 We here demonstrate that the neurokinin substance-P (Sub-P) activates a neurokinin-3 receptor (NK-3R) in rabbit, prolonging action potential (AP) duration through inhibition of a background potassium current. Potassium 190-199 neuromedin-K receptor Oryctolagus cuniculus 72-93 30341287-3 2018 We here demonstrate that the neurokinin substance-P (Sub-P) activates a neurokinin-3 receptor (NK-3R) in rabbit, prolonging action potential (AP) duration through inhibition of a background potassium current. Potassium 190-199 neuromedin-K receptor Oryctolagus cuniculus 95-100 29902467-0 2018 Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice. Potassium 86-95 FXYD domain-containing ion transport regulator 1 Mus musculus 23-28 29902467-6 2018 Deletion of one Fxyd1 allele also prevented the increased extracellular potassium (K+) accumulation observed in cerebro-cortical neurons from Mecp2 KO animals in response to the NKA inhibitor ouabain, and rescued the loss of dendritic arborization observed in FC neurons of Mecp2 KO mice. Potassium 72-81 FXYD domain-containing ion transport regulator 1 Mus musculus 16-21 29902467-6 2018 Deletion of one Fxyd1 allele also prevented the increased extracellular potassium (K+) accumulation observed in cerebro-cortical neurons from Mecp2 KO animals in response to the NKA inhibitor ouabain, and rescued the loss of dendritic arborization observed in FC neurons of Mecp2 KO mice. Potassium 72-81 methyl CpG binding protein 2 Mus musculus 142-147 29935238-8 2018 atp8 and nad2 showed the lowest similarity and the highest Ka/Ks ratios, indicating that both genes have potential for studying species identification and populations genetics in apple snails. Potassium 62-64 ATP synthase F0 subunit 8 Malus domestica 0-4 29935238-8 2018 atp8 and nad2 showed the lowest similarity and the highest Ka/Ks ratios, indicating that both genes have potential for studying species identification and populations genetics in apple snails. Potassium 62-64 NADH dehydrogenase subunit 2 Malus domestica 9-13 30189384-5 2018 Serum analyses revealed the presence of anti-neuronal antibodies directed against anti-contactin-associated protein 2 (anti-Caspr2), a protein associated with voltage-gated potassium neuronal channels. Potassium 173-182 contactin associated protein 2 Homo sapiens 124-130 30199632-3 2018 These can be significant in large systems, so to account for them we test a simple correction to XSAPT(KS)+ aiD, where "KS" indicates the use of Kohn-Sham orbitals. Potassium 120-122 activation induced cytidine deaminase Homo sapiens 108-111 30199632-6 2018 With the nonadditive dispersion correction, XSAPT(KS)+ aiD affords errors of ~1 kcal/mol for isomers of F-(H2O)10 and (H2O)20, where the benchmarks are complete-basis CCSD(T) energies, as well as for ion-water clusters X(H2O) n where n <= 6 and X = F-, Cl-, SO42-, Li+, Na+, or K+. Potassium 50-52 activation induced cytidine deaminase Homo sapiens 55-58 30054673-10 2018 Glucose-stimulated first-phase insulin secretion and potassium-stimulated insulin secretion decreased by 53% and 59%, respectively, in perfused pancreases of 10-week-old Wfs1-/- mice compared with wild-type (WT) mice. Potassium 53-62 insulin Homo sapiens 74-81 29923766-4 2018 Chloride regulates WNK kinases in vitro by binding to the active site and inhibiting autophosphorylation and has been proposed to modulate WNK activity in the distal convoluted tubule in response to low dietary potassium. Potassium 211-220 Wnk kinase Drosophila melanogaster 19-22 30120881-1 2018 Na+ , K+ -ATPase (NKA) activity, which establishes the sodium and potassium gradient across the cell membrane and is instrumental in the propagation of the nerve impulses, is altered in a number of neurological and neuropsychiatric disorders, including autism spectrum disorders (ASD). Potassium 66-75 tachykinin precursor 1 Homo sapiens 0-16 30120881-1 2018 Na+ , K+ -ATPase (NKA) activity, which establishes the sodium and potassium gradient across the cell membrane and is instrumental in the propagation of the nerve impulses, is altered in a number of neurological and neuropsychiatric disorders, including autism spectrum disorders (ASD). Potassium 66-75 tachykinin precursor 1 Homo sapiens 18-21 30054673-10 2018 Glucose-stimulated first-phase insulin secretion and potassium-stimulated insulin secretion decreased by 53% and 59%, respectively, in perfused pancreases of 10-week-old Wfs1-/- mice compared with wild-type (WT) mice. Potassium 53-62 wolframin ER transmembrane glycoprotein Mus musculus 170-174 30153627-2 2018 KCNQ4 channels are crucial to the internal ear potassium recycling. Potassium 47-56 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 0-5 29982385-0 2018 New potassium binders reduce the risk of hyperkalaemia in patients treated with renin-angiotensin-aldosterone system inhibitors. Potassium 4-13 renin Homo sapiens 80-85 30176543-1 2018 BACKGROUND: To determine if variations exist in the KSHV host receptor EPHA2"s coding region that affect KSHV infectivity and/or KS prevalence among South African HIV-infected patients. Potassium 52-54 EPH receptor A2 Homo sapiens 71-76 30176543-5 2018 Aggregate variation across the entire EPHA2 coding region identified an association with KS (OR = 6.6 (95% CI 2.8, 15.9), p = 2.2 x 10-5). Potassium 89-91 EPH receptor A2 Homo sapiens 38-43 30176543-11 2018 CONCLUSIONS: Variations in the KSHV entry receptor gene EPHA2 affected susceptibility to KSHV infection and KS development in a South African HIV-infected patient cohort. Potassium 31-33 EPH receptor A2 Homo sapiens 56-61 29969132-8 2018 A possible open state of the TMEM175 channel was modelled by the in silico expansion of the hydrophobic gate resulting in the wetting of the pore and free permeation of potassium ions through the channel. Potassium 169-178 transmembrane protein 175 Homo sapiens 29-36 30106427-7 2018 The meta-analysis revealed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels than the groups not given C-peptide. Potassium 105-114 insulin Homo sapiens 50-59 30106427-9 2018 However, the meta-analysis showed that the animals given C-peptide had lower glomerular volumes and lower urine potassium levels. Potassium 112-121 insulin Homo sapiens 57-66 30323912-0 2018 An association of urinary sodium-potassium ratio with insulin resistance among Korean adults. Potassium 33-42 insulin Homo sapiens 54-61 30323912-1 2018 BACKGROUND/OBJECTIVES: This study was conducted to investigate the effects of sodium-potassium ratio on insulin resistance and sensitivity in Korean adults. Potassium 85-94 insulin Homo sapiens 104-111 30323912-5 2018 The generalized linear model was applied to determine the association between urinary sodium-potassium ratio and insulin resistance. Potassium 93-102 insulin Homo sapiens 113-120 30323912-8 2018 CONCLUSION: The present study suggests that high sodium-potassium ratio is related to high insulin resistance and low insulin sensitivity. Potassium 56-65 insulin Homo sapiens 91-98 30323912-8 2018 CONCLUSION: The present study suggests that high sodium-potassium ratio is related to high insulin resistance and low insulin sensitivity. Potassium 56-65 insulin Homo sapiens 118-125 30323912-9 2018 Decreasing sodium intake and increasing potassium intake are important for maintaining insulin sensitivity. Potassium 40-49 insulin Homo sapiens 87-94 30262858-4 2018 Several naturally occurring potassium ionophores (e.g. salinomycin) were shown to inhibit P-gp effectively. Potassium 28-37 phosphoglycolate phosphatase Homo sapiens 90-94 30254284-5 2018 Membrane depolarization by high extracellular potassium maintained PSD-95 puncta density and partially rescued both spontaneous synaptic activity and cell death, while spike generation remained blocked. Potassium 46-55 discs large MAGUK scaffold protein 4 Homo sapiens 67-73 30231975-3 2018 (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection. Potassium 35-44 gasdermin D Homo sapiens 20-25 29894319-5 2018 It was reported that Kir4.1/Kir5.1 serves as potassium sensors in the distal nephron responding to variations in dietary intake and hormonal stimuli. Potassium 45-54 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 21-27 30260982-10 2018 When neurites of NGF cultured somata were grown in GDNF, capsaicin evoked a lower CGRP release than high potassium, compared to those grown in NGF. Potassium 105-114 nerve growth factor Mus musculus 17-20 30254424-0 2018 Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy. Potassium 75-84 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 39-44 30271488-9 2018 In the multivariate Cox model, the extent of vascular invasion, tumour count, fibrinogen, HBV DNA load and serum potassium significantly affected prognosis. Potassium 113-122 cytochrome c oxidase subunit 8A Homo sapiens 20-23 30185776-7 2018 Finally, SARS 3a activates caspase-1 either directly or via an enhanced potassium efflux, which triggers NLRP3 inflammasome assembly. Potassium 72-81 seryl-tRNA synthetase 1 Homo sapiens 9-13 30185776-7 2018 Finally, SARS 3a activates caspase-1 either directly or via an enhanced potassium efflux, which triggers NLRP3 inflammasome assembly. Potassium 72-81 caspase 1 Homo sapiens 27-36 30185776-7 2018 Finally, SARS 3a activates caspase-1 either directly or via an enhanced potassium efflux, which triggers NLRP3 inflammasome assembly. Potassium 72-81 NLR family pyrin domain containing 3 Homo sapiens 105-110 30838349-12 2018 Molecular modelling showed Kir2.2 p.Thr140Met to reduce movement of potassium ions towards binding sites in the hetero-tetramer pore compatible with a reduced maximal current. Potassium 68-77 potassium inwardly rectifying channel subfamily J member 12 Homo sapiens 27-33 29719168-5 2018 The Panx1 channel activated by various physiological stimuli or by increased concentrations of extracellular potassium ions has a large conductance (~500 pS, however, with multiple, long-lasting subconductance states) and is nonselectively permeable to small molecules, including ATP. Potassium 109-118 pannexin 1 Homo sapiens 4-9 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 1 Homo sapiens 124-128 29846116-3 2018 The role played by KS-WNK1 in the modulation of the WNK/STE20-proline-alanine rich kinase (SPAK)/NCC pathway remains elusive. Potassium 19-21 WNK lysine deficient protein kinase 1 Homo sapiens 22-26 29846116-3 2018 The role played by KS-WNK1 in the modulation of the WNK/STE20-proline-alanine rich kinase (SPAK)/NCC pathway remains elusive. Potassium 19-21 serine/threonine kinase 39 Homo sapiens 91-95 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 14-16 WNK lysine deficient protein kinase 1 Homo sapiens 17-21 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 14-16 serine/threonine kinase 39 Homo sapiens 155-159 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 14-16 WNK lysine deficient protein kinase 1 Homo sapiens 170-174 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 167-169 WNK lysine deficient protein kinase 1 Homo sapiens 17-21 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 167-169 serine/threonine kinase 39 Homo sapiens 155-159 29846116-6 2018 The effect of KS-WNK1 was abrogated by eliminating a WNK-WNK-interacting domain and by a specific WNK inhibitor, WNK463, indicating that the activation of SPAK/NCC by KS-WNK1 is due to interaction with another WNK kinase. Potassium 167-169 WNK lysine deficient protein kinase 1 Homo sapiens 170-174 29846116-8 2018 In contrast, this serine becomes phosphorylated when the intracellular chloride concentration ([Cl-]i) is reduced or when KS-WNK1 is coexpressed with WNK4. Potassium 122-124 WNK lysine deficient protein kinase 1 Homo sapiens 125-129 29846116-8 2018 In contrast, this serine becomes phosphorylated when the intracellular chloride concentration ([Cl-]i) is reduced or when KS-WNK1 is coexpressed with WNK4. Potassium 122-124 WNK lysine deficient protein kinase 4 Homo sapiens 150-154 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 1 Homo sapiens 3-7 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 4 Homo sapiens 31-35 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 1 Homo sapiens 124-128 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 4 Homo sapiens 133-137 29846116-9 2018 KS-WNK1-mediated activation of WNK4 is not due to a decrease of the [Cl-]i. Coimmunoprecipitation analysis revealed that KS-WNK1 and WNK4 interact with each other and that WNK4 becomes autophosphorylated at serine 335 when it is associated with KS-WNK1. Potassium 0-2 WNK lysine deficient protein kinase 4 Homo sapiens 133-137 29846116-10 2018 Together, these observations suggest that WNK4 becomes active in the presence of KS-WNK1, despite a constant [Cl-]i. Potassium 81-83 WNK lysine deficient protein kinase 4 Homo sapiens 42-46 29846116-10 2018 Together, these observations suggest that WNK4 becomes active in the presence of KS-WNK1, despite a constant [Cl-]i. Potassium 81-83 WNK lysine deficient protein kinase 1 Homo sapiens 84-88 29767559-9 2018 In addition, feeding a high-potassium diet significantly increased both GPS2 and BK protein abundance in mice. Potassium 28-37 G protein pathway suppressor 2 Mus musculus 72-76 29958895-7 2018 Here, using the established bioconjugation methodology, we show how steroid bioconjugation at the allosteric site affects the heme spin state, the binding affinity (KS) of CYP3A4 for testosterone, as well as the enzyme coupling efficiency. Potassium 165-167 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 172-178 29894319-5 2018 It was reported that Kir4.1/Kir5.1 serves as potassium sensors in the distal nephron responding to variations in dietary intake and hormonal stimuli. Potassium 45-54 potassium inwardly-rectifying channel, subfamily J, member 16 Rattus norvegicus 28-34 29957655-8 2018 Whereas renal potassium reabsorption is mediated by upregulation of potassium retaining transporters (HKA2) and downregulation of potassium secreting channels (ROMK, BK). Potassium 14-23 keratin 32 Homo sapiens 102-106 29957655-8 2018 Whereas renal potassium reabsorption is mediated by upregulation of potassium retaining transporters (HKA2) and downregulation of potassium secreting channels (ROMK, BK). Potassium 14-23 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 160-164 30234232-4 2018 Hyperkalaemia is also indirectly associated with the progression of CKD; in fact higher serum potassium levels may lead to withdrawal of renin-angiotensin-system inhibiting drugs that currently represent the most effective tools to postpone ESRD. Potassium 94-103 renin Homo sapiens 137-142 30146013-11 2018 Thus, we demonstrate an important contribution of pendrin in renal regulation of sodium chloride, potassium and acid-base homeostasis and in the pathophysiology of PHAII. Potassium 98-107 solute carrier family 26, member 4 Mus musculus 50-57 29725771-7 2018 Serum potassium concentration (X +- SD) was higher in SLC4A1 group (3.66 +- 0.44 mEq/L) than in ATP6V0A4 group (2.96 +- 0.63 mEq/L) (p = 0.046). Potassium 6-15 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 54-60 29995632-7 2018 Serum insulin, cortisol and glucose did not correlate with IGF-I concentrations, but serum potassium showed a negative correlation (rho=-0.364; p<0.0001) with IGF-I concentrations. Potassium 91-100 insulin like growth factor 1 Homo sapiens 162-167 29719087-0 2018 Regulation of inward rectifier potassium current ionic channel remodeling by AT1 -Calcineurin-NFAT signaling pathway in stretch-induced hypertrophic atrial myocytes. Potassium 31-40 nuclear factor of activated T-cells 5 Rattus norvegicus 94-98 30169531-0 2018 KCNJ11 variants and their effect on the association between serum potassium and diabetes risk in the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts. Potassium 66-75 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 0-6 30161182-1 2018 The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (Gi/o) whose activation leads to the inhibition of both cAMP production and calcium channel activity, and to the stimulation of potassium currents. Potassium 241-250 prepronociceptin Cricetulus griseus 4-14 30161182-1 2018 The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (Gi/o) whose activation leads to the inhibition of both cAMP production and calcium channel activity, and to the stimulation of potassium currents. Potassium 241-250 prepronociceptin Homo sapiens 43-46 29976759-7 2018 Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion. Potassium 30-39 serum amyloid A cluster Mus musculus 127-130 29976759-7 2018 Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion. Potassium 30-39 interleukin 1 beta Mus musculus 140-148 29976759-7 2018 Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion. Potassium 90-99 serum amyloid A cluster Mus musculus 127-130 29976759-7 2018 Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion. Potassium 90-99 interleukin 1 beta Mus musculus 140-148 30283826-8 2018 Patients with somatic KCNJ5 mutations required more potassium supplementation and had adrenal histology compatible with zona fasciculata-like cells compared with patients without the mutations (all P < 0.05). Potassium 52-61 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 22-27 30111140-2 2018 Due to the underlying symmetry of the potassium ions on the mica surface, the contact layers prefer to adopt an incommensurate square or rhombic symmetry. Potassium 38-47 MHC class I polypeptide-related sequence A Homo sapiens 60-64 30097648-0 2018 Adenosine Kinase couples sensing of cellular potassium depletion to purine metabolism. Potassium 45-54 adenosine kinase Mus musculus 0-16 30078841-6 2018 In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate (ATP) release, potassium depletion and lysosomal damage. Potassium 110-119 NLR family pyrin domain containing 3 Homo sapiens 37-42 30127740-1 2018 Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. Potassium 20-29 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 53-59 30082733-1 2018 We recently reported the reduced ATP-sensitive potassium (KATP) channel activities in the transgenic mouse heart overexpressing the vascular type KATP channel pore-forming subunit (Kir6.1). Potassium 47-56 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 181-187 29476442-1 2018 Mutations in KCNJ10, which encodes the inwardly rectifying potassium channel Kir4.1, a primary regulator of membrane excitability and potassium homeostasis, cause a complex syndrome characterized by seizures, sensorineural deafness, ataxia, intellectual disability, and electrolyte imbalance called SeSAME/EAST syndrome. Potassium 59-68 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 13-19 30180643-2 2018 Mica muscovite is a particularly interesting material, because there exist fossil and experimental evidence for nonlinear excitations transporting localized energy and charge along the cation rows within the potassium layers. Potassium 208-217 MHC class I polypeptide-related sequence A Homo sapiens 0-4 29617054-0 2018 Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes. Potassium 74-83 ETS transcription factor ERG Homo sapiens 61-64 29330622-1 2018 Crop available soil potassium is generally low and on the decline in the southeastern states of the USA because of the increasing crop and runoff removal and decreasing application of potassium fertilizer. Potassium 20-29 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 0-4 29330622-1 2018 Crop available soil potassium is generally low and on the decline in the southeastern states of the USA because of the increasing crop and runoff removal and decreasing application of potassium fertilizer. Potassium 20-29 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 130-134 29330622-1 2018 Crop available soil potassium is generally low and on the decline in the southeastern states of the USA because of the increasing crop and runoff removal and decreasing application of potassium fertilizer. Potassium 184-193 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 0-4 29995632-10 2018 The inverse correlation of IGF-I and serum potassium concentrations after injections of rhIGF-I has not been reported before and warrants further consideration. Potassium 43-52 insulin like growth factor 1 Homo sapiens 27-32 29694931-2 2018 This study assessed whether urinary potassium excretion is related to simultaneously calculated creatinine clearance (CrCl) and can predict AKI in the critically ill. MATERIALS AND METHODS: In this prospective cohort study, the correlation between 2-h urinary potassium excretion and simultaneously calculated CrCl of 61 critically ill patients was assessed by Pearson"s correlation coefficient, and their ability to predict AKI (>=stage 1 KDIGO) in the subsequent 7 days was assessed by area under the receiver-operating-characteristic (AUROC) curve. Potassium 36-45 CRCL Homo sapiens 118-122 29694931-2 2018 This study assessed whether urinary potassium excretion is related to simultaneously calculated creatinine clearance (CrCl) and can predict AKI in the critically ill. MATERIALS AND METHODS: In this prospective cohort study, the correlation between 2-h urinary potassium excretion and simultaneously calculated CrCl of 61 critically ill patients was assessed by Pearson"s correlation coefficient, and their ability to predict AKI (>=stage 1 KDIGO) in the subsequent 7 days was assessed by area under the receiver-operating-characteristic (AUROC) curve. Potassium 36-45 CRCL Homo sapiens 310-314 29694931-4 2018 CONCLUSIONS: Urinary potassium excretion correlates with CrCl and predicts AKI in the critically ill without recent furosemide exposure. Potassium 21-30 CRCL Homo sapiens 57-61 32026957-4 2018 A potassium concentration after recovery from VT was 6.4 mEq/L, which was normalized by the administration of calcium gluconate, furosemide, and insulin with glucose. Potassium 2-11 insulin Homo sapiens 145-152 29745804-14 2018 The beta2 agonist salbutamol lowered potassium during exercise and late recovery but not during early postexercise, suggesting a protective effect against severe hypokalemia. Potassium 37-46 ATPase H+ transporting V0 subunit a2 Homo sapiens 4-9 29603743-4 2018 In the present study, inhibiting NO, PGs, Na+ /K+ -ATPase and inwardly rectifying potassium (KIR ) channels did not blunt augmented hyperaemia during hypoxic exercise beyond previous observations with NO/PG block alone. Potassium 82-91 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 93-96 29603743-9 2018 We hypothesized that combined inhibition of NO, PGs, Na+ /K+ -ATPase and inwardly rectifying potassium (KIR ) channels would abolish the augmented hyperaemic response in HypEx. Potassium 93-102 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 104-107 29859980-2 2018 Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decreased sodium-activated potassium currents in medial nucleus of the trapezoid body neurons of the Fmr1-knockout (KO) mouse representing a mouse model of the human Fragile-X-Syndrome (FXS) and autism. Potassium 148-157 potassium channel, subfamily T, member 1 Mus musculus 0-5 29859980-2 2018 Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decreased sodium-activated potassium currents in medial nucleus of the trapezoid body neurons of the Fmr1-knockout (KO) mouse representing a mouse model of the human Fragile-X-Syndrome (FXS) and autism. Potassium 148-157 fragile X messenger ribonucleoprotein 1 Mus musculus 89-93 29859980-2 2018 Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decreased sodium-activated potassium currents in medial nucleus of the trapezoid body neurons of the Fmr1-knockout (KO) mouse representing a mouse model of the human Fragile-X-Syndrome (FXS) and autism. Potassium 148-157 fragile X messenger ribonucleoprotein 1 Mus musculus 107-111 29859980-2 2018 Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decreased sodium-activated potassium currents in medial nucleus of the trapezoid body neurons of the Fmr1-knockout (KO) mouse representing a mouse model of the human Fragile-X-Syndrome (FXS) and autism. Potassium 148-157 fragile X messenger ribonucleoprotein 1 Mus musculus 222-226 20301512-10 1993 DIAGNOSIS/TESTING: The diagnosis of HOKPP is based on a history of episodes of flaccid paralysis with rapid installation and spontaneous recovery; low serum concentration of potassium (0.9 to 3.0 mmol/L) during attacks, but not between attacks; the identification of typical precipitating factors (i.e., rest after a strong physical exertion, prolonged immobility); and a family history consistent with autosomal dominant inheritance. Potassium 174-183 calcium voltage-gated channel subunit alpha1 S Homo sapiens 36-41 29958799-1 2018 Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Potassium 0-9 NLR family, pyrin domain containing 3 Mus musculus 105-110 29767755-0 2018 A protein phosphatase 2C, AP2C1, interacts with and negatively regulates the function of CIPK9 under potassium-deficient conditions in Arabidopsis. Potassium 101-110 Protein phosphatase 2C family protein Arabidopsis thaliana 26-31 29767755-0 2018 A protein phosphatase 2C, AP2C1, interacts with and negatively regulates the function of CIPK9 under potassium-deficient conditions in Arabidopsis. Potassium 101-110 CBL-interacting protein kinase 9 Arabidopsis thaliana 89-94 29791245-5 2018 The accumulation of potassium and other cations in PI(3,5)P2-deficient yeast is relieved by mutations that inactivate Vnx1 or inactivate the V-ATPase and by mutations that increase the activity of a vacuolar cation export channel, Yvc1. Potassium 20-29 Vnx1p Saccharomyces cerevisiae S288C 118-122 29791245-5 2018 The accumulation of potassium and other cations in PI(3,5)P2-deficient yeast is relieved by mutations that inactivate Vnx1 or inactivate the V-ATPase and by mutations that increase the activity of a vacuolar cation export channel, Yvc1. Potassium 20-29 Yvc1p Saccharomyces cerevisiae S288C 231-235 29784874-4 2018 Kir2.1 maintains potassium homeostasis in heart muscle cells, and Kir2.1 defects lead to human disease. Potassium 17-26 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 0-6 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Ldb19p Saccharomyces cerevisiae S288C 32-37 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Ldb19p Saccharomyces cerevisiae S288C 38-42 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Aly1p Saccharomyces cerevisiae S288C 44-48 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Aly1p Saccharomyces cerevisiae S288C 49-53 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Aly2p Saccharomyces cerevisiae S288C 59-63 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 Aly2p Saccharomyces cerevisiae S288C 64-68 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 109-115 29784874-6 2018 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium 222-231 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 158-164 29961781-4 2018 Our results demonstrate the key role of the structure of the mica surfaces, specifically the positions of potassium (K+) ions, in determining the nature of sliding friction with monolayer lubricants, including the presence or absence of stick-slip dynamics. Potassium 106-115 MHC class I polypeptide-related sequence A Homo sapiens 61-65 29962164-7 2018 The order of importance was phosphatase activity > pH > sucrase activity > catalase activity > total N > available P > available K > soil moisture content > urease activity > electrical conductivity (EC); phosphatase activity, pH value, invertase activity, catalase activity, total nitrogen, available phosphorus, and available potassium showed significant correlation with SOC and SIC (P<0.01). Potassium 355-364 catalase isozyme 1-like Gossypium hirsutum 84-92 29726949-12 2018 Serum potassium but not urinary free cortisol correlated with pNKCC2, pNCC, and Na+-Cl- cotransporter (NCC) in uEVs. Potassium 6-15 solute carrier family 12 member 3 Homo sapiens 80-101 30018331-5 2018 By targeting both the MHC class I complex (beta-2-microglobulin) and a broadly expressed sodium-potassium ATPase-subunit (CD298) with platinum-conjugated antibodies, human immune cells, stem cells as well as tumor cells could be multiplexed in the same single-cell assay. Potassium 96-105 ATPase Na+/K+ transporting subunit beta 3 Homo sapiens 122-127 29661658-0 2018 Is Transcellular Potassium Shifting With Insulin, Albuterol, or Sodium Bicarbonate in Emergency Department Patients With Hyperkalemia Associated With Recurrent Hyperkalemia After Dialysis? Potassium 17-26 insulin Homo sapiens 41-48 29703946-1 2018 Potassium channel Kv2.1 regulates potassium current in cortical neurons and potassium efflux is necessary for cell apoptosis. Potassium 34-43 potassium voltage-gated channel subfamily B member 1 Homo sapiens 18-23 29703946-1 2018 Potassium channel Kv2.1 regulates potassium current in cortical neurons and potassium efflux is necessary for cell apoptosis. Potassium 76-85 potassium voltage-gated channel subfamily B member 1 Homo sapiens 18-23 29703946-7 2018 Our study suggests that BACE2 plays a neuroprotective role by cleavage of Kv2.1 to prevent the outward potassium currents, a potential new target for Alzheimer"s treatment. Potassium 103-112 beta-secretase 2 Homo sapiens 24-29 29703946-7 2018 Our study suggests that BACE2 plays a neuroprotective role by cleavage of Kv2.1 to prevent the outward potassium currents, a potential new target for Alzheimer"s treatment. Potassium 103-112 potassium voltage-gated channel subfamily B member 1 Homo sapiens 74-79 30271961-2 2018 Here, we report the role of Kir4.1 channels in NG2-glia during brain development, potassium signaling, and in an ischemic stroke disease model. Potassium 82-91 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 28-34 29953543-1 2018 KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative membrane potential for influxing calcium ions. Potassium 74-83 potassium calcium-activated channel subfamily N member 4 Homo sapiens 0-6 29953543-1 2018 KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative membrane potential for influxing calcium ions. Potassium 74-83 potassium calcium-activated channel subfamily N member 4 Homo sapiens 22-25 29953543-1 2018 KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative membrane potential for influxing calcium ions. Potassium 74-83 potassium calcium-activated channel subfamily N member 4 Homo sapiens 29-32 29988564-1 2018 Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling). Potassium 199-208 ryanodine receptor 1 Homo sapiens 57-61 29988564-1 2018 Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling). Potassium 199-208 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 67-79 29988564-1 2018 Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling). Potassium 199-208 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 81-85 29928032-1 2018 Two-pore domain potassium channels (K2P) constitute major candidates for the regulation of background potassium currents in mammalian cells. Potassium 16-25 keratin 76 Homo sapiens 36-39 29481897-10 2018 The equivalent reduction in potassium current in the WT neurons following application of the appropriate amount of DTX-kappa reproduced the enhanced firing abilities of KO neurons, suggesting the Kv1.1 channel as a critical contributor to the hyperexcitability of KO neurons. Potassium 28-37 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 196-201 30245542-7 2018 The fitted value of Ks =1.01 x 10-3 m min-1 at the Torrance drywell was consistent with the sandy soil texture at this site and the default value for sand in the HYDRUS soil catalog. Potassium 20-22 CD59 molecule (CD59 blood group) Homo sapiens 38-43 30245542-8 2018 The drywell with this Ks = 1.01 x 10-3 m min-1 could easily infiltrate predicted surface runoff from a design rain event (~51.3 m3) within 5760 min (4 d). Potassium 22-24 CD59 molecule (CD59 blood group) Homo sapiens 41-46 30245542-9 2018 In contrast, the fitted value of Ks=2.25 x 10-6 m min-1 at Fort Irwin was very low compared to the Torrance drywell and more than an order of magnitude smaller than the default value reported in the HYDRUS soil catalog for sandy clay loam at this site, likely due to clogging. Potassium 33-35 CD59 molecule (CD59 blood group) Homo sapiens 50-55 29726949-12 2018 Serum potassium but not urinary free cortisol correlated with pNKCC2, pNCC, and Na+-Cl- cotransporter (NCC) in uEVs. Potassium 6-15 solute carrier family 12 member 3 Homo sapiens 71-74 29726949-15 2018 Potassium has recently been identified as an important driver of NCC activity, and low serum potassium may also contribute to increased renal sodium reabsorption and hypertension in CS. Potassium 0-9 solute carrier family 12 member 3 Homo sapiens 65-68 29549164-4 2018 The promalignant nature of Kir2.1 in gastric cancer cells was independent of potassium permeation but relied on its interaction with serine/threonine-protein kinase 38 (Stk38) to inhibit ubiquitination and degradation of mitogen-activated protein kinase kinase kinase 2 (MEKK2). Potassium 77-86 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 27-33 29942493-6 2018 Patients with CLCNKB mutations had the lowest serum potassium and serum magnesium and the highest serum bicarbonate levels. Potassium 52-61 chloride voltage-gated channel Kb Homo sapiens 14-20 29523497-14 2018 Elevated serum creatinine (OR 1 3; p=0 046), aspartate aminotransferase (OR 1 5; p=0 075), and potassium (OR 3 6; p=0 0024) were independent predictors of death. Potassium 95-104 olfactory receptor family 7 subfamily E member 22 pseudogene Homo sapiens 106-112 29741884-4 2018 A formally zerovalent cobalt complex has different structures depending on whether potassium binds; potassium binding gives transfer of two electrons into the eta2-diazoalkane, but the removal of the potassium with crown ether leads to a form with only one electron transferred into an eta1-diazoalkane. Potassium 83-92 DNA polymerase iota Homo sapiens 159-163 29741884-4 2018 A formally zerovalent cobalt complex has different structures depending on whether potassium binds; potassium binding gives transfer of two electrons into the eta2-diazoalkane, but the removal of the potassium with crown ether leads to a form with only one electron transferred into an eta1-diazoalkane. Potassium 83-92 secreted phosphoprotein 1 Homo sapiens 286-290 29741884-4 2018 A formally zerovalent cobalt complex has different structures depending on whether potassium binds; potassium binding gives transfer of two electrons into the eta2-diazoalkane, but the removal of the potassium with crown ether leads to a form with only one electron transferred into an eta1-diazoalkane. Potassium 100-109 DNA polymerase iota Homo sapiens 159-163 29741884-4 2018 A formally zerovalent cobalt complex has different structures depending on whether potassium binds; potassium binding gives transfer of two electrons into the eta2-diazoalkane, but the removal of the potassium with crown ether leads to a form with only one electron transferred into an eta1-diazoalkane. Potassium 100-109 DNA polymerase iota Homo sapiens 159-163 29696970-3 2018 It was shown that the chiral center at C-4 plays a crucial role in controlling desymmetrization of the cyclopropenyl moiety, instigated by a profound potassium-templated effect. Potassium 150-159 complement C4A (Rodgers blood group) Homo sapiens 39-42 29524437-5 2018 We showed that the orthosteric mGluR2 agonist LY379268 (0.1 microM, 1 microM and 10 microM) and mGluR5 positive allosteric modulator CDPPB (1 microM and 10 microM) both attenuated potassium-evoked dopamine release, underscoring their role in modulating dopamine neurotransmission in the nucleus accumbens. Potassium 180-189 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 31-37 29524437-5 2018 We showed that the orthosteric mGluR2 agonist LY379268 (0.1 microM, 1 microM and 10 microM) and mGluR5 positive allosteric modulator CDPPB (1 microM and 10 microM) both attenuated potassium-evoked dopamine release, underscoring their role in modulating dopamine neurotransmission in the nucleus accumbens. Potassium 180-189 glutamate receptor, ionotropic, kainate 1 Mus musculus 96-102 29712960-1 2018 We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. Potassium 129-138 D-box binding PAR bZIP transcription factor Homo sapiens 85-88 29499411-0 2018 GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297. Potassium 35-44 potassium inwardly-rectifying channel, subfamily J, member 3 Mus musculus 0-5 29134558-9 2018 In this case, DAPA treatment could potentially increase the requirement for mineralocorticoid replacement, directly suggesting that the SGLT2 inhibition-induced natriuretic effect is accompanied by compensatory activation of the RAAS axis, which is essential to keep the serum potassium level within the normal range. Potassium 277-286 solute carrier family 5 member 2 Homo sapiens 136-141 28791698-5 2018 Correspondingly, the OCT1-deficient individuals had a 1.5-fold stronger increase in heart rate (P = 0.002), a 3.4-fold greater increase in blood glucose (P = 3.0 x 10-5 ), and significantly lower serum potassium levels. Potassium 202-211 solute carrier family 22 member 1 Homo sapiens 21-25 29806042-2 2018 Even newly released anti-arrhythmic drugs, like ivabradine with HCN channel as a primary target, block the hERG potassium current in overlapping concentration interval. Potassium 112-121 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 64-67 29806042-2 2018 Even newly released anti-arrhythmic drugs, like ivabradine with HCN channel as a primary target, block the hERG potassium current in overlapping concentration interval. Potassium 112-121 ETS transcription factor ERG Homo sapiens 107-111 29648633-3 2018 In the current study we determined the role of urotensin-II in the regulation of transient outward A-type potassium currents (IA) and neuronal excitability in trigeminal ganglion (TG) neurons. Potassium 106-115 urotensin 2 Homo sapiens 47-59 29602832-4 2018 Drosophila WNK activity in tubules also increased or decreased when bath potassium concentration decreased or increased, respectively. Potassium 73-82 Wnk kinase Drosophila melanogaster 11-14 29700922-0 2018 The responses of the inflammatory marker, pentraxin 3, to dietary sodium and potassium interventions. Potassium 77-86 pentraxin 3 Homo sapiens 42-53 29700922-8 2018 Potassium supplementation inhibited salt-induced increase in pentraxin-3 (0.56 +- 0.21 ng/mL vs 0.68 +- 0.26 ng/mL, P = .015). Potassium 0-9 pentraxin 3 Homo sapiens 61-72 29700922-10 2018 We found a positive correlation between the ln-transformed concentrations of pentraxin-3 and 24-hour urinary sodium during low and high Na+ periods (r = .269, P = .012) and a negative relationship with 24 hours urinary potassium excretion during high-salt and high-salt plus potassium periods (r = -.246, P = .02). Potassium 219-228 pentraxin 3 Homo sapiens 77-88 29700922-10 2018 We found a positive correlation between the ln-transformed concentrations of pentraxin-3 and 24-hour urinary sodium during low and high Na+ periods (r = .269, P = .012) and a negative relationship with 24 hours urinary potassium excretion during high-salt and high-salt plus potassium periods (r = -.246, P = .02). Potassium 275-284 pentraxin 3 Homo sapiens 77-88 29700922-13 2018 Dietary salt and potassium interventions significantly altered circulating pentraxin-3. Potassium 17-26 pentraxin 3 Homo sapiens 75-86 29699633-8 2018 In addition, PT-miR-17-92-/- mice showed higher levels of serum potassium and phosphonium after the IRI operation. Potassium 64-73 Mir17 host gene (non-protein coding) Mus musculus 16-25 28623618-6 2018 The hyperpolarizing effect of ET-1 appears to be orchestrated via modulation of membrane conductances, namely voltage-gated sodium current (I Na) and outward transient potassium current (I KT). Potassium 168-177 endothelin 1 Rattus norvegicus 30-34 28623618-8 2018 Additionally, ET-1 (100 nM) significantly potentiated the transient component (I KT) of the potassium currents. Potassium 92-101 endothelin 1 Rattus norvegicus 14-18 29668703-5 2018 Here, we demonstrate a novel vasodilatory action of +-PZQ in mesenteric vessels that are precontracted by high potassium-evoked depolarization, an effect previously reported to be associated with agonists of the transient receptor potential melastatin 8 channel (TRPM8). Potassium 111-120 transient receptor potential cation channel subfamily M member 8 Homo sapiens 212-261 29668703-5 2018 Here, we demonstrate a novel vasodilatory action of +-PZQ in mesenteric vessels that are precontracted by high potassium-evoked depolarization, an effect previously reported to be associated with agonists of the transient receptor potential melastatin 8 channel (TRPM8). Potassium 111-120 transient receptor potential cation channel subfamily M member 8 Homo sapiens 263-268 29367066-6 2018 The magnitude of brush layer lower critical solution temperature reduction was found to follow the order F- > CH3CO2- > Cl- > NO3- ~ Br- > I- > SCN- for the potassium series and Na+ > K+ > Cs+ > Li+ ~ NH4+ for the chloride salts. Potassium 172-181 NBL1, DAN family BMP antagonist Homo sapiens 135-138 29460236-2 2018 XEN-D0103 is a nanomolar ion channel blocker that selectively inhibits potassium ion flux through the Kv1.5 ion channel. Potassium 71-80 potassium voltage-gated channel subfamily A member 5 Homo sapiens 102-107 29681847-9 2018 Reduced nAChR-mediated anti-inflammation due to the loss of nicotinic innervation might lead to the transformation of glial cells and release of inflammatory mediators, lowering the buffering of extracellular potassium and glutamate metabolism. Potassium 209-218 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 8-13 29483285-12 2018 We show that the KV8.2 subunit interacts with different Kv2 channels in rods and cones, giving rise to potassium currents with distinct functional properties. Potassium 103-112 potassium voltage-gated channel modifier subfamily V member 2 Homo sapiens 17-22 29432900-0 2018 Thermodynamic analysis of Kex2 activity: The acylation and deacylation steps are potassium- and substrate-dependent. Potassium 81-90 kexin KEX2 Saccharomyces cerevisiae S288C 26-30 29432900-3 2018 Potassium bound Kex2 with KD=20.3mM. Potassium 0-9 kexin KEX2 Saccharomyces cerevisiae S288C 16-20 29671960-0 2018 Renal potassium handling in carriers of the Gly40Ser mutation of the glucagon receptor suggests a role for glucagon in potassium homeostasis. Potassium 6-15 glucagon receptor Homo sapiens 69-86 29310825-0 2018 Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel. Potassium 0-9 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 103-109 29310825-1 2018 Kir4.1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). Potassium 74-83 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 0-6 29310825-3 2018 High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. Potassium 5-14 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 75-81 29310825-3 2018 High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. Potassium 5-14 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 237-243 29310825-3 2018 High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. Potassium 54-63 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 75-81 29310825-4 2018 In contrast, low potassium intake activated Kir4.1, increased potassium currents, and hyperpolarized the distal convoluted tubule membrane. Potassium 17-26 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 44-50 29310825-5 2018 These effects of dietary potassium intake on the basolateral potassium conductance and membrane potential in the distal convoluted tubule were completely absent in inducible kidney-specific Kir4.1 knockout mice. Potassium 25-34 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 190-196 29310825-9 2018 Finally, hypokalemia and metabolic alkalosis in kidney-specific Kir4.1 knockout mice were exacerbated by potassium restriction and only partially corrected by a high-potassium diet. Potassium 105-114 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 64-70 29310825-9 2018 Finally, hypokalemia and metabolic alkalosis in kidney-specific Kir4.1 knockout mice were exacerbated by potassium restriction and only partially corrected by a high-potassium diet. Potassium 166-175 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 64-70 29310825-10 2018 Thus, Kir4.1 plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis. Potassium 72-81 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 6-12 29310825-10 2018 Thus, Kir4.1 plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis. Potassium 109-118 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 6-12 29671960-0 2018 Renal potassium handling in carriers of the Gly40Ser mutation of the glucagon receptor suggests a role for glucagon in potassium homeostasis. Potassium 119-128 glucagon receptor Homo sapiens 69-86 29671960-2 2018 Insulin is known to favor potassium entry into cells. Potassium 26-35 insulin Homo sapiens 0-7 29590095-6 2018 Our model validates previous experimental observations that both Kir4.1 channels and gap junctions play important roles in regulating the concentration of extracellular potassium. Potassium 169-178 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 65-71 29305421-2 2018 The fast component of the delayed rectifier potassium currents responsible for repolarization of the cardiac action potential, Ikr, is encoded by the human ether-a-go-go related gene (hERG) channel. Potassium 44-53 ETS transcription factor ERG Homo sapiens 184-188 29311259-2 2018 ROMK, also known as Kir1.1 (KCNJ1), is the major route for potassium secretion into the pro-urine and plays an indispensable role in regulating serum potassium and urinary concentrations. Potassium 59-68 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-4 29566502-1 2018 We analyze the entropic effects of inner pore geometry changes of Kv 1.2 channel during membrane depolarization and their implications for the rate of transmembrane transport of potassium ions. Potassium 178-187 potassium voltage-gated channel subfamily A member 2 Homo sapiens 66-72 29540778-4 2018 Here we demonstrated that Kir6.1-containing ATP-sensitive potassium (Kir6.1/K-ATP) channel switched microglia from the detrimental M1 phenotype toward the beneficial M2 phenotype. Potassium 58-67 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 26-32 29540778-4 2018 Here we demonstrated that Kir6.1-containing ATP-sensitive potassium (Kir6.1/K-ATP) channel switched microglia from the detrimental M1 phenotype toward the beneficial M2 phenotype. Potassium 58-67 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 69-75 29446937-4 2018 Decreasing potassium concentration leads to a contraction of the RhO6 octahedral layers, which may be attributed to a higher covalency of Rh-O bonds. Potassium 11-20 Rho family GTPase 1 Homo sapiens 65-69 29311259-2 2018 ROMK, also known as Kir1.1 (KCNJ1), is the major route for potassium secretion into the pro-urine and plays an indispensable role in regulating serum potassium and urinary concentrations. Potassium 150-159 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-4 29311259-5 2018 However, sufficient ROMK levels on the plasma membrane rescued growth on low-potassium medium of yeast cells lacking endogenous potassium channels. Potassium 77-86 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 20-24 29311259-7 2018 Therefore, we used a synthetic genetic array to identify non-essential genes that reduce the plasma membrane pool of ROMK in potassium-sensitive yeast cells. Potassium 125-134 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 117-121 29274961-0 2018 Technical note: Development and validation of a new method for the quantification of soluble and micellar calcium, magnesium, and potassium in milk. Potassium 130-139 Weaning weight-maternal milk Bos taurus 143-147 28915228-5 2018 Of the total 766 patients, those with rare variants in exon 13 of either SCNN1B or SCNN1G had a significantly earlier onset of hypertension (24.7 +- 7.5 vs. 29.0 +- 7.7 years, P = 0.015) and lower serum potassium (3.57 +- 0.59 vs. 3.96 +- 0.41 mmol/l, P = 0.007) than those without rare variants. Potassium 203-212 sodium channel epithelial 1 subunit beta Homo sapiens 73-79 28915228-5 2018 Of the total 766 patients, those with rare variants in exon 13 of either SCNN1B or SCNN1G had a significantly earlier onset of hypertension (24.7 +- 7.5 vs. 29.0 +- 7.7 years, P = 0.015) and lower serum potassium (3.57 +- 0.59 vs. 3.96 +- 0.41 mmol/l, P = 0.007) than those without rare variants. Potassium 203-212 sodium channel epithelial 1 subunit gamma Homo sapiens 83-89 29146137-6 2018 RESULTS: Phosphorus, potassium, and sodium additives were present on the ingredient list in 37%, 9%, and 72% of MPF, respectively. Potassium 21-30 mesothelin Homo sapiens 112-115 29146137-9 2018 CONCLUSIONS: The use of additives in packaged MPF products as indicated by the ingredient list can significantly contribute to the dietary phosphorus and potassium loads in patients with CKD. Potassium 154-163 mesothelin Homo sapiens 46-49 29129401-7 2018 Mice lacking both claudin-10 and -16 in the thick ascending limb recruited downstream compensatory mechanisms and showed hypertrophic distal convoluted tubules with changes in gene expression and phosphorylation of ion transporters in this segment, presumably triggered by the mild decrease in serum potassium. Potassium 300-309 claudin 10 Mus musculus 18-36 29483649-5 2018 Enzymatic analysis has confirmed that efficient GTP hydrolysis by MFN1 requires potassium. Potassium 80-89 mitofusin 1 Homo sapiens 66-70 29474462-2 2018 Retinal Muller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Potassium 52-61 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 100-106 29464197-9 2018 Astrocytes from Mecp2-deficient mice express significantly less Kir4.1 mRNA and protein, which translates into a >50% deficiency in Ba2+-sensitive Kir4.1-mediated currents, and impaired extracellular potassium dynamics. Potassium 203-212 methyl CpG binding protein 2 Mus musculus 16-21 29459730-1 2018 NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. Potassium 79-88 TANK binding kinase 1 Homo sapiens 0-3 29294000-8 2018 Electrophysiological examinations in transfected HEK293 cells showed that both the L319R and N255K mutants resulted in reduced potassium currents and respective altered gating properties, with a dominant negative effect on the Kv1.1 wild-type channel. Potassium 127-136 potassium voltage-gated channel subfamily A member 1 Homo sapiens 227-232 29237822-0 2018 Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Potassium 0-9 WNK lysine deficient protein kinase 1 Mus musculus 65-69 29237822-7 2018 The formation of WNK bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique N-terminal exon of KS-WNK1. Potassium 141-143 WNK lysine deficient protein kinase 1 Mus musculus 144-148 29237822-8 2018 We propose that WNK bodies are not pathological aggregates, but rather are KS-WNK1-dependent microdomains of the DCT cytosol that modulate WNK signaling during physiological shifts in potassium balance. Potassium 75-77 WNK lysine deficient protein kinase 1 Mus musculus 78-82 29237822-8 2018 We propose that WNK bodies are not pathological aggregates, but rather are KS-WNK1-dependent microdomains of the DCT cytosol that modulate WNK signaling during physiological shifts in potassium balance. Potassium 184-193 WNK lysine deficient protein kinase 1 Mus musculus 78-82 28374925-7 2018 The clinical profile associated with inactivating HNRNPK mutations supports the idea that the associated disorder should be considered as a distinct nosologic entity clinically related to KS, and that the condition should be considered in differential diagnosis with KS, in particular in subjects exhibiting brain malformation (nodular heterotopia), craniosynostosis, and polydactyly. Potassium 188-190 heterogeneous nuclear ribonucleoprotein K Homo sapiens 50-56 28374925-7 2018 The clinical profile associated with inactivating HNRNPK mutations supports the idea that the associated disorder should be considered as a distinct nosologic entity clinically related to KS, and that the condition should be considered in differential diagnosis with KS, in particular in subjects exhibiting brain malformation (nodular heterotopia), craniosynostosis, and polydactyly. Potassium 267-269 heterogeneous nuclear ribonucleoprotein K Homo sapiens 50-56 29031006-6 2018 Glucagon-like peptide-1 (GLP-1) has been reported to increase glomerular filtration rate (GFR), renal blood flow, and the fractional excretion both of sodium and potassium, with renal GLP-1 receptors present in afferent arteriolar vascular smooth muscle cells, glomerular endothelial cells and macrophages, juxtaglomerular cells, and the proximal tubule, perhaps mediating the greater natriuresis seen after oral than intravenous sodium. Potassium 162-171 glucagon Homo sapiens 0-23 29031006-6 2018 Glucagon-like peptide-1 (GLP-1) has been reported to increase glomerular filtration rate (GFR), renal blood flow, and the fractional excretion both of sodium and potassium, with renal GLP-1 receptors present in afferent arteriolar vascular smooth muscle cells, glomerular endothelial cells and macrophages, juxtaglomerular cells, and the proximal tubule, perhaps mediating the greater natriuresis seen after oral than intravenous sodium. Potassium 162-171 glucagon Homo sapiens 25-30 28892166-10 2018 The Ka/Ks ratio (>1) in the SHB region indicates that anti-HBs might have exerted selection pressure on the HBsAg. Potassium 7-9 SH2 domain containing adaptor protein B Homo sapiens 31-34 29245016-12 2018 Finally, electrophysiological studies showed that the inwardly rectifying potassium current (IK1) was evenly present in AF- and Ctr-CMPC in basal conditions and similarly disappeared after TGF-beta1 exposure. Potassium 74-83 IKAROS family zinc finger 1 Homo sapiens 93-96 29245016-12 2018 Finally, electrophysiological studies showed that the inwardly rectifying potassium current (IK1) was evenly present in AF- and Ctr-CMPC in basal conditions and similarly disappeared after TGF-beta1 exposure. Potassium 74-83 transforming growth factor beta 1 Homo sapiens 189-198 29384476-6 2018 Interestingly, fatigue in P2ry1 mutants was more greatly exacerbated by exposure to high potassium than in control mice. Potassium 89-98 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 26-31 29384476-7 2018 High potassium itself increased cytosolic levels of calcium in TPSCs, a response which was also reduced P2ry1 mutants. Potassium 5-14 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 104-109 29326302-6 2018 In Bsndneo/neo mice, SPAK and NCC activation after consuming a low-potassium diet was clearly impaired compared with that in wild-type (WT) mice. Potassium 67-76 serine/threonine kinase 39 Mus musculus 21-25 29326302-7 2018 In ex vivo kidney slice experiment, the increase in pNCC and SPAK in low-potassium medium was also impaired in Bsndneo/neo mice. Potassium 73-82 serine/threonine kinase 39 Mus musculus 61-65 29326302-9 2018 Thus, our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. Potassium 69-78 barttin CLCNK type accessory beta subunit Mus musculus 95-102 29326302-9 2018 Thus, our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. Potassium 69-78 WNK lysine deficient protein kinase 4 Mus musculus 149-153 29374044-0 2018 Inhibitory Effect of Vascular Endothelial Growth Factor on the Slowly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes. Potassium 99-108 Vegfa Cavia porcellus 21-55 29374044-3 2018 In the present study, we investigated the effects of different concentrations of VEGF on delayed rectifier potassium currents (IK) in guinea pig ventricular myocytes and their effects on action potential (AP) parameters. Potassium 107-116 Vegfa Cavia porcellus 81-85 29374044-7 2018 We found that VEGF inhibited the slowly activating delayed rectifier potassium current (IKs) in a concentration-dependent manner (18.13+-1.04 versus 12.73+-0.34, n=5, P=0.001; 12.73+-0.34 versus 9.05+-1.20, n=5, P=0.036) and prolonged AP duration (894.5+-36.92 versus 746.3+-33.71, n=5, P=0.021). Potassium 69-78 Vegfa Cavia porcellus 14-18 29203171-3 2018 This functionality allows the classical NLRP3 pathway to serve as a highly sensitive, but non-specific surveillance mechanism responding to any type of perturbation that breaches plasma membrane integrity and the associated potassium gradient across the membrane. Potassium 224-233 NLR family pyrin domain containing 3 Homo sapiens 40-45 29203171-4 2018 Here, we review our current knowledge on potassium efflux-dependent NLRP3 activation, with a special focus on how major cell death programs are rendered pro-inflammatory by secondary NLRP3 activation. Potassium 41-50 NLR family pyrin domain containing 3 Homo sapiens 68-73 29203171-4 2018 Here, we review our current knowledge on potassium efflux-dependent NLRP3 activation, with a special focus on how major cell death programs are rendered pro-inflammatory by secondary NLRP3 activation. Potassium 41-50 NLR family pyrin domain containing 3 Homo sapiens 183-188 29338715-12 2018 ND4 Ka/Ks ratios were highly correlated with SST (Mantel, p-value: 0.0001; GLM, p-value: 0.00001) and thus may be related to climate adaptation throughout penguin speciation. Potassium 7-9 ND4 Pygoscelis adeliae 0-3 29317612-3 2018 We discovered the development of this activity in the CA1 region of horizontal slices after prolonged interictal-like epileptiform activity in the CA3 region that was provoked by incubation in high potassium artificial cerebrospinal fluid. Potassium 198-207 carbonic anhydrase 1 Rattus norvegicus 54-57 30408810-10 2018 The serum CT-1 concentrations were positively correlated with the 24-h urinary sodium-to-potassium (Na/K) excretion ratios during both of the LS and HS diet intervention periods in SS subjects (r = 0.621, p < 0.01), but this correlation was not evident in SR subjects (r = 0.208, p = 0.107). Potassium 89-98 cardiotrophin 1 Homo sapiens 10-14 29359681-0 2018 Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians. Potassium 63-72 NLR family pyrin domain containing 3 Homo sapiens 15-20 29359681-0 2018 Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians. Potassium 63-72 insulin Homo sapiens 76-83 28987626-0 2018 NO involvement in the inhibition of ghrelin on voltage-dependent potassium currents in rat hippocampal cells. Potassium 65-74 ghrelin and obestatin prepropeptide Rattus norvegicus 36-43 28987626-2 2018 In this study, we examined the effect of ghrelin on voltage-dependent potassium (K+) currents in hippocampal cells of 1-3 days SD rats by whole-cell patch-clamp technique, and discussed whether NO was involved in this process. Potassium 70-79 ghrelin and obestatin prepropeptide Rattus norvegicus 41-48 30138927-10 2018 RESULTS: Elevated extracellular potassium prevented the priming factor IL-1alpha from inducing the production of reactive oxygen species (ROS). Potassium 32-41 interleukin 1 alpha Homo sapiens 71-80 29669325-1 2018 BACKGROUND/AIMS: The replacement of the amino acid valine at position 388 (Shaker position 438) in hKv1.3 channels or at the homologue position 370 in hKv1.2 channels resulted in a channel with two different ion conducting pathways: One pathway was the central, potassium-selective alpha-pore, that was sensitive to block by peptide toxins (CTX or KTX in the hKv1.3_V388C channel and CTX or MTX in the hKv1.2_V370C channel). Potassium 262-271 potassium voltage-gated channel subfamily A member 2 Homo sapiens 151-157 30070159-2 2018 KChIPs constitute a group of specific auxiliary beta-subunits for Kv4 channels, the molecular substrate of transient potassium currents in both neuronal and non-neuronal tissues. Potassium 117-126 potassium voltage-gated channel subfamily C member 1 Homo sapiens 66-69 30854950-6 2018 RESULTS: Mineralocorticoid receptor antagonists result in significant improvement in blood pressure and serum potassium level among patients with primary aldosteronism. Potassium 110-119 nuclear receptor subfamily 3 group C member 2 Homo sapiens 9-35 28826578-4 2018 RESULTS: SGLT2 inhibitors induce small increases in serum concentrations of magnesium, potassium and phosphate. Potassium 87-96 solute carrier family 5 member 2 Homo sapiens 9-14 30099444-15 2018 CONCLUSION: We found that in patients with CKD, urinary sodium and potassium excretion is closely correlated to renal handling of uric acid, which was pronounced in hypertensive patients with low eGFR. Potassium 67-76 epidermal growth factor receptor Homo sapiens 196-200 29115510-10 2018 Therefore, HGF may be important in potassium excretion and perform antihyperkalemic effects through the translocation of potassium channels. Potassium 35-44 hepatocyte growth factor Rattus norvegicus 11-14 28677029-6 2018 The alteration of KCC2 expression affects GABAergic and glycinergic neurotransmissions, because KCC2 is a potassium-chloride exporter and serves to maintain intracellular chloride concentration. Potassium 106-115 solute carrier family 12 member 5 Homo sapiens 18-22 28677029-6 2018 The alteration of KCC2 expression affects GABAergic and glycinergic neurotransmissions, because KCC2 is a potassium-chloride exporter and serves to maintain intracellular chloride concentration. Potassium 106-115 solute carrier family 12 member 5 Homo sapiens 96-100 29045814-0 2018 Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization. Potassium 23-32 solute carrier family 12, member 5 Mus musculus 8-12 29045814-9 2018 Our model predicts that interneuron stimulation triggered an increase of interneuron firing, which was accompanied by an increase in the intracellular chloride concentration and a subsequent KCC2-dependent gradual accumulation of the extracellular potassium promoting epileptiform ictal activity. Potassium 248-257 solute carrier family 12, member 5 Mus musculus 191-195 29358904-1 2017 Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Potassium 20-29 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 31-39 29448255-0 2018 Intrathecal Administration of CXCL1 Enhances Potassium Currents in Microglial Cells. Potassium 45-54 chemokine (C-X-C motif) ligand 1 Mus musculus 30-35 29448255-3 2018 In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. Potassium 74-83 chemokine (C-X-C motif) ligand 1 Mus musculus 65-70 29448255-3 2018 In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. Potassium 74-83 chemokine (C-X3-C motif) receptor 1 Mus musculus 107-113 29448255-4 2018 The results showed that CXCL1 hyperpolarized the cells by enhancing inward rectifying potassium currents and increasing the membrane area, suggesting an activating effect on microglia. Potassium 86-95 chemokine (C-X-C motif) ligand 1 Mus musculus 24-29 29273710-7 2017 On in-vitro analysis, potassium under Th17 polarizing conditions significantly inhibited IL-17 and interferon-[Formula: see text] expression while favoring the induction of FoxP3+ T cells. Potassium 22-31 interleukin 17A Homo sapiens 89-94 29273710-7 2017 On in-vitro analysis, potassium under Th17 polarizing conditions significantly inhibited IL-17 and interferon-[Formula: see text] expression while favoring the induction of FoxP3+ T cells. Potassium 22-31 forkhead box P3 Homo sapiens 173-178 29383177-4 2017 The wild-type (WT) or mutant T361S of Kv4.3 protein (encoded by KCND3) were co-expressed with the auxiliary subunit K+ channel-Interacting Protein (KChIP2) in HEK293 cells, and transient outward potassium current (Ito) were recorded using patch-clamp methods, and the surface or total protein levels of Kv4.3 were analyzed by western blot. Potassium 195-204 potassium voltage-gated channel subfamily D member 3 Homo sapiens 38-43 29234037-3 2017 We have previously demonstrated that during pathological conditions such as polycystic kidney disease, polycystin 2 (TRPP2) inhibits the activity of potassium-selective MSCs through a filamin A-mediated cytoskeletal effect, and renders tubular epithelial cells susceptible to apoptosis. Potassium 149-158 polycystin 2, transient receptor potential cation channel Homo sapiens 103-115 29234037-3 2017 We have previously demonstrated that during pathological conditions such as polycystic kidney disease, polycystin 2 (TRPP2) inhibits the activity of potassium-selective MSCs through a filamin A-mediated cytoskeletal effect, and renders tubular epithelial cells susceptible to apoptosis. Potassium 149-158 polycystin 2, transient receptor potential cation channel Homo sapiens 117-122 29234037-3 2017 We have previously demonstrated that during pathological conditions such as polycystic kidney disease, polycystin 2 (TRPP2) inhibits the activity of potassium-selective MSCs through a filamin A-mediated cytoskeletal effect, and renders tubular epithelial cells susceptible to apoptosis. Potassium 149-158 filamin A Homo sapiens 184-193 29234037-5 2017 In this study we use a combination of electrophysiology, structured illumination microscopy, and fluorescence recovery after photobleaching (FRAP) to examine the dynamic nature of the TRPP2-mediated cytoskeletal inhibition of the potassium-selective MSC TREK1. Potassium 230-239 polycystin 2, transient receptor potential cation channel Homo sapiens 184-189 29206101-5 2017 Here, we show that serotonin (5HT), which is known to regulate gamma power, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs. Potassium 134-143 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 85-90 28643868-11 2017 This potassium battery can be tapped by opening AKT2-like potassium channels and then enables the ATP-independent energization of other transport processes, such as the reloading of sucrose. Potassium 5-14 AKT serine/threonine kinase 2 Homo sapiens 48-52 29212953-3 2017 Here, we report an unexpected role for the ubiquitin ligase Siah1 in adrenal gland development and PA. Siah1a-/- mice exhibit altered adrenal gland morphology, as reflected by a diminished X-zone, enlarged medulla, and dysregulated zonation of the glomerulosa as well as increased aldosterone levels and aldosterone target gene expression and reduced plasma potassium levels. Potassium 358-367 siah E3 ubiquitin protein ligase 1 Homo sapiens 60-65 29212953-3 2017 Here, we report an unexpected role for the ubiquitin ligase Siah1 in adrenal gland development and PA. Siah1a-/- mice exhibit altered adrenal gland morphology, as reflected by a diminished X-zone, enlarged medulla, and dysregulated zonation of the glomerulosa as well as increased aldosterone levels and aldosterone target gene expression and reduced plasma potassium levels. Potassium 358-367 siah E3 ubiquitin protein ligase 1A Mus musculus 103-109 29126483-6 2017 The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Potassium 171-180 immunoglobulin kappa variable 1-16 Homo sapiens 159-162 29126483-6 2017 The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Potassium 171-180 immunoglobulin kappa variable 1-16 Homo sapiens 159-162 29126483-6 2017 The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Potassium 171-180 immunoglobulin kappa variable 1-16 Homo sapiens 159-162 29126483-6 2017 The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Potassium 171-180 immunoglobulin kappa variable 1-16 Homo sapiens 159-162 29126483-6 2017 The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Potassium 171-180 immunoglobulin kappa variable 1-16 Homo sapiens 159-162 28961511-7 2017 Kn/Ks values were between 0 and 1, suggesting the purifying selection among BnAP2/ERF TFs. Potassium 3-5 floral homeotic protein APETALA 2 Brassica napus 76-81 29126768-4 2017 To elucidate the mechanisms underlying 5-HT1AAR supersensitivity in Tph2-/- mice, we characterized the activation of G protein-coupled inwardly-rectifying potassium (GIRK) conductance by the 5-HT1A receptor agonist 5-carboxamidotryptamine using whole-cell recordings from serotonergic neurons in dorsal raphe nucleus. Potassium 155-164 tryptophan hydroxylase 2 Mus musculus 68-72 29126768-4 2017 To elucidate the mechanisms underlying 5-HT1AAR supersensitivity in Tph2-/- mice, we characterized the activation of G protein-coupled inwardly-rectifying potassium (GIRK) conductance by the 5-HT1A receptor agonist 5-carboxamidotryptamine using whole-cell recordings from serotonergic neurons in dorsal raphe nucleus. Potassium 155-164 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 191-206 29087023-3 2017 Rank correlation analysis revealed that interleukin 6 expression exhibited significant positive correlations with urinary sodium (R = .13) and sodium to potassium ratio (R = .13). Potassium 153-162 interleukin 6 Homo sapiens 40-53 28934190-0 2017 People with the major alleles of ATP2B1 rs17249754 increases the risk of hypertension in high ratio of sodium and potassium, and low calcium intakes. Potassium 114-123 ATPase plasma membrane Ca2+ transporting 1 Homo sapiens 33-39 28976587-11 2017 CONCLUSION: In patients with renal insufficiency and hyperkalemia, 5 units of insulin reduced serum potassium to the same extent as 10 units of insulin but with a lower rate of hypoglycemia. Potassium 100-109 insulin Homo sapiens 78-85 29114015-7 2017 By contrast, high HKT1 expression in the root repressed lateral root development, which could be partially rescued by addition of potassium. Potassium 130-139 high-affinity K+ transporter 1 Arabidopsis thaliana 18-22 28992755-10 2017 Drug-induced enhancement of an alternative potassium current, IKATP, also reduced APD by up to 21%. Potassium 43-52 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 62-67 29208215-2 2017 The present study assessed the association of plasma potassium (cK) with serum aldosterone and insulin concentrations, since these hormones are involved in the regulation of potassium homeostasis. Potassium 53-62 insulin Bos taurus 95-102 28526352-0 2017 Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias. Potassium 18-27 potassium two pore domain channel subfamily K member 2 Homo sapiens 60-66 29111379-2 2017 Another disease also caused by mutations in the gene SCN4A is called myotonia aggravated by potassium (OMIM 170500, 613345). Potassium 92-101 sodium voltage-gated channel alpha subunit 4 Homo sapiens 53-58 29033128-4 2017 Instead, detection of cytosolic DNA by the cGAS-STING axis induces a cell death program initiating potassium efflux upstream of NLRP3. Potassium 99-108 NLR family pyrin domain containing 3 Homo sapiens 128-133 29170665-9 2017 This IL-1beta secretion was regulated by the NLRP3 inflammasome and was dependent on potassium efflux and Caspase-1. Potassium 85-94 interleukin 1 beta Homo sapiens 5-13 28918394-5 2017 When ApoL1 and lipid were allowed to interact at low pH and were then brought to neutral pH, chloride permeability was suppressed, and potassium permeability was activated. Potassium 135-144 apolipoprotein L1 Homo sapiens 5-10 28918394-6 2017 Both chloride and potassium permeability linearly correlated with the mass of ApoL1 in the reaction mixture, and both exhibited lipid selectivity, requiring the presence of negatively charged lipids for activity. Potassium 18-27 apolipoprotein L1 Homo sapiens 78-83 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 29-34 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 40-45 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 157-162 28976808-1 2017 In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. Potassium 68-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 167-172 28988768-5 2017 KCNK3 antagonizes norepinephrine-induced membrane depolarization by promoting potassium efflux in brown adipocytes. Potassium 78-87 potassium channel, subfamily K, member 3 Mus musculus 0-5 28833536-6 2017 Both recurrent cases showed complete KS remission after tapering immunosuppression therapy and/or switching a calcineurin inhibitor to a mammalian target of rapamycin inhibitor. Potassium 37-39 mechanistic target of rapamycin kinase Homo sapiens 137-166 28729291-2 2017 Here, we show that the NLRP3-activating agonists, ATP and nigericin, prevent STING pathway activation in association with mitochondrial fragmentation; however, the suppression of the STING pathway and mitochondria fission were not dependent on NLRP3 or potassium efflux. Potassium 253-262 NLR family pyrin domain containing 3 Homo sapiens 23-28 28888605-2 2017 Acidemia negatively affects the cellular response to insulin and may therefore result in deranged glucose, potassium, and phosphorus homeostasis. Potassium 107-116 insulin Bos taurus 53-60 29110762-6 2017 Recent experimental evidence has shown that aberrant efflux of intracellular potassium is an early event in APOL1-induced death of human embryonic kidney cells. Potassium 77-86 apolipoprotein L1 Homo sapiens 108-113 29110762-7 2017 Here, we discuss the possibility that abnormal efflux of cellular potassium or other cations may be relevant to the pathogenesis of APOL1 nephropathy. Potassium 66-75 apolipoprotein L1 Homo sapiens 132-137 29031279-1 2017 We report measurements of rate coefficients at T 600 K for rotationally inelastic collisions of NaK molecules in the 2(A)1Sigma+ electronic state with helium, argon, and potassium atom perturbers. Potassium 172-181 TANK binding kinase 1 Homo sapiens 98-101 28602864-7 2017 Thus, the potassium/sodium/calcium exchanger of NCKX3 KO mice proceeded normally in this study. Potassium 10-19 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Mus musculus 48-53 28904126-5 2017 Treatment of primary monocytes with the NLRP3 inhibitor MCC950 or with extracellular potassium significantly reduced IL-1beta cleavage and release in response to T. gondii infection, without affecting the release of TNF-alpha, and indicated a role for the inflammasome sensor NLRP3 and for potassium efflux in T. gondii-induced IL-1beta production. Potassium 85-94 NLR family pyrin domain containing 3 Homo sapiens 276-281 28904126-5 2017 Treatment of primary monocytes with the NLRP3 inhibitor MCC950 or with extracellular potassium significantly reduced IL-1beta cleavage and release in response to T. gondii infection, without affecting the release of TNF-alpha, and indicated a role for the inflammasome sensor NLRP3 and for potassium efflux in T. gondii-induced IL-1beta production. Potassium 290-299 NLR family pyrin domain containing 3 Homo sapiens 40-45 28904126-8 2017 To our knowledge, these findings are the first to identify NLRP3 as an inflammasome sensor for T. gondii in primary human peripheral blood cells and to define an upstream regulator of its activation through the release of intracellular potassium. Potassium 236-245 NLR family pyrin domain containing 3 Homo sapiens 59-64 28978809-3 2017 Using the ApoE-deficient mouse model, we demonstrated for the first time to our knowledge that reduced dietary potassium (0.3%) promoted atherosclerotic vascular calcification and increased aortic stiffness, compared with normal (0.7%) potassium-fed mice. Potassium 111-120 apolipoprotein E Mus musculus 10-14 28978809-5 2017 Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification. Potassium 34-43 cAMP responsive element binding protein 1 Mus musculus 155-192 28978809-5 2017 Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification. Potassium 34-43 cAMP responsive element binding protein 1 Mus musculus 194-198 28978809-6 2017 Inhibition of calcium signals and knockdown of either CREB or ATG7, an autophagy regulator, attenuated VSMC calcification induced by low potassium. Potassium 137-146 cAMP responsive element binding protein 1 Mus musculus 54-58 28978809-6 2017 Inhibition of calcium signals and knockdown of either CREB or ATG7, an autophagy regulator, attenuated VSMC calcification induced by low potassium. Potassium 137-146 autophagy related 7 Mus musculus 62-66 28978809-7 2017 Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo. Potassium 105-114 cAMP responsive element binding protein 1 Mus musculus 37-41 28978809-7 2017 Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo. Potassium 171-180 cAMP responsive element binding protein 1 Mus musculus 37-41 28877968-6 2017 In a small fraction of cells, there was a component of calcium-dependent potassium current that showed frequency-dependent reduction, but the contribution to overall potassium current reduction was almost always much smaller than that of Kv3-mediated current. Potassium 73-82 potassium voltage-gated channel subfamily A member 3 Rattus norvegicus 238-241 28701322-8 2017 In whole cell recordings from slices in vitro, AT1AR-GFP neurons exhibited voltage-activated potassium currents, including the transient outward current and the M-type potassium current. Potassium 93-102 angiotensin II receptor type 1 Homo sapiens 47-52 28701322-8 2017 In whole cell recordings from slices in vitro, AT1AR-GFP neurons exhibited voltage-activated potassium currents, including the transient outward current and the M-type potassium current. Potassium 168-177 angiotensin II receptor type 1 Homo sapiens 47-52 27882824-3 2017 A phosphorus level of at least 3 mM and K:P molar ratio over 3 were necessary to form MPP, which showed higher content rate of phosphorus and potassium in precipitate. Potassium 142-151 M-phase phosphoprotein 6 Homo sapiens 86-89 28856417-3 2017 Activity of HBD-1 and Pep-B was determined against actively growing M. tb in vitro, inside monocyte-derived macrophages (MDMs) and dormant bacilli in in vitro potassium deficiency and human peripheral blood mononuclear cell (PBMC) granuloma models using colony-forming unit enumeration. Potassium 159-168 defensin beta 1 Homo sapiens 12-17 28856417-3 2017 Activity of HBD-1 and Pep-B was determined against actively growing M. tb in vitro, inside monocyte-derived macrophages (MDMs) and dormant bacilli in in vitro potassium deficiency and human peripheral blood mononuclear cell (PBMC) granuloma models using colony-forming unit enumeration. Potassium 159-168 peptidase B Homo sapiens 22-27 28499801-7 2017 Univariate Cox regression identified potassium levels outside the interval of <3.5 to 4.5mmol/L to be a risk factor for both in-hospital and long-term death. Potassium 37-46 cytochrome c oxidase subunit 8A Homo sapiens 11-14 28734179-7 2017 The p.Asn439Lys and p.Asp445Asn may interfere in binding interactions of MTHFD1 protein with cesium cation and potassium. Potassium 111-120 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 73-79 28748724-4 2017 Areas covered: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been linked with the scarce, but serious, complication of euglycemic diabetic ketoacidosis, as well as with an increase in serum potassium, magnesium and phosphorus levels. Potassium 199-208 solute carrier family 5 member 2 Homo sapiens 15-45 28748724-4 2017 Areas covered: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been linked with the scarce, but serious, complication of euglycemic diabetic ketoacidosis, as well as with an increase in serum potassium, magnesium and phosphorus levels. Potassium 199-208 solute carrier family 5 member 2 Homo sapiens 47-52 28748724-7 2017 Insulin administration is associated with a reduction in serum potassium, magnesium and phosphorus concentration, along with reduced renal magnesium excretion. Potassium 63-72 insulin Homo sapiens 0-7 29076349-2 2017 Potassium efflux through Kir1.1 compliments the role of transporters and sodium channels that are the targets of known diuretics. Potassium 0-9 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 25-31 28552344-4 2017 ASP2905 potently inhibited potassium currents in CHO cells expressing KCNH3 (IC50 = 9.0nM). Potassium 27-36 potassium voltage-gated channel subfamily H member 3 Cricetulus griseus 70-75 28639369-8 2017 Furthermore, renal markers (creatinine and NGAL) closely associated with potassium and glucose. Potassium 73-82 lipocalin 2 Homo sapiens 43-47 27615678-10 2017 The presence of a potassium-binding pocket within the active site of mammalian TyrRS compensates the absence of the second lysine in the KMSKS motif. Potassium 18-27 tyrosyl-tRNA synthetase 1 Homo sapiens 79-84 29056256-5 2017 Treatment with the potassium ionophore nigericin significantly increased the level of activated caspase-1. Potassium 19-28 caspase 1 Homo sapiens 96-105 28567665-1 2017 In adulthood, an induced nephron-specific deficiency of alphaENaC (Scnn1a) resulted in pseudohypoaldosteronism type 1 (PHA-1) with sodium loss, hyperkalemia, and metabolic acidosis that is rescued through high-sodium/low-potassium (HNa+/LK+) diet. Potassium 221-230 sodium channel, nonvoltage-gated 1 alpha Mus musculus 67-73 28993757-11 2017 Thus, we speculated this insulin-induced sharp drop in serum potassium levels as potentiating the patient"s already existing advanced diabetic neuropathy, thereby leading to muscle cramping. Potassium 61-70 insulin Homo sapiens 25-32 28993757-13 2017 This tilted our diagnosis toward the insulin-induced acute drop in serum potassium levels as the most likely etiology underlying the patient"s cramps. Potassium 73-82 insulin Homo sapiens 37-44 28849814-5 2017 In this work, we employ microsecond-scale all-atom molecular dynamics simulations to investigate the differences in the structural ensembles in sodium-bound/unbound and potassium-bound/unbound thrombin. Potassium 169-178 coagulation factor II, thrombin Homo sapiens 193-201 28849814-10 2017 Our study of thrombin in the presence of sodium/potassium ions suggests Na+-mediated generalized allostery is the mechanism of thrombin"s functional switch between the "fast" and "slow" forms. Potassium 48-57 coagulation factor II, thrombin Homo sapiens 13-21 28849814-10 2017 Our study of thrombin in the presence of sodium/potassium ions suggests Na+-mediated generalized allostery is the mechanism of thrombin"s functional switch between the "fast" and "slow" forms. Potassium 48-57 coagulation factor II, thrombin Homo sapiens 127-135 29955681-10 2017 Consumption of "pasta mixed dishes" was associated with a 5% increase in both potassium and sodium intakes (~150 and 190 mg/d, respectively). Potassium 78-87 solute carrier family 45 member 1 Homo sapiens 16-21 29955681-13 2017 These pasta patterns contribute in different ways to diet quality and intakes of fiber, sodium, and potassium. Potassium 100-109 solute carrier family 45 member 1 Homo sapiens 6-11 28821664-9 2017 Prolonged activation of somatic MORs in POMC neurons robustly inhibited action potential firing and Ca2+ activity despite desensitization of the MOR and reduced activation of a potassium current over the same time course. Potassium 177-186 pro-opiomelanocortin-alpha Mus musculus 40-44 28821664-9 2017 Prolonged activation of somatic MORs in POMC neurons robustly inhibited action potential firing and Ca2+ activity despite desensitization of the MOR and reduced activation of a potassium current over the same time course. Potassium 177-186 opioid receptor, mu 1 Mus musculus 32-35 28924484-6 2017 After starting insulin and rapid hemodialysis, the serum potassium level was normalized. Potassium 57-66 insulin Homo sapiens 15-22 29031359-7 2017 Additionally, we discuss the role of new agents designed to bind potassium in the gastrointestinal tract that can be used to maintain normokalemia in patients who previously developed hyperkalemia on renin-angiotensin-aldosterone blockers. Potassium 65-74 renin Homo sapiens 200-205 27440776-0 2017 (Pro)Renin receptor regulates potassium homeostasis through a local mechanism. Potassium 30-39 ATPase H+ transporting accessory protein 2 Rattus norvegicus 5-19 28556923-2 2017 However, ivabradine also inhibits human ether-a-go-go (hERG) mediated potassium currents. Potassium 70-79 ETS transcription factor ERG Homo sapiens 55-59 28614115-2 2017 Loss of function mutations in the NKCC2 gene cause urinary salt and potassium wasting, whereas excessive NKCC2 function has been linked to high blood pressure. Potassium 68-77 solute carrier family 12 member 1 Homo sapiens 34-39 28698302-9 2017 Interaction of CYP2J2 with DZ produced a type II binding spectrum with a Ks of 2.8 muM and the IC50 for loss of OHEB carboxylation activity was 0.18 muM. Potassium 73-75 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 15-21 28833693-10 2017 An application of TGF-beta1 itself attenuated generation of action potentials, inhibited sodium current and potentiated potassium currents. Potassium 120-129 transforming growth factor, beta 1 Rattus norvegicus 18-27 28926857-0 2017 The Amelioration of Insulin Resistance in Salt Loading Subjects by Potassium Supplementation is Associated with a Reduction in Plasma IL-17A Levels. Potassium 67-76 insulin Homo sapiens 20-27 28926857-0 2017 The Amelioration of Insulin Resistance in Salt Loading Subjects by Potassium Supplementation is Associated with a Reduction in Plasma IL-17A Levels. Potassium 67-76 interleukin 17A Homo sapiens 134-140 28926857-7 2017 Results Participants exhibited increased plasma insulin level, as well as progressed HOMA-IR, during a high-salt diet intervention, which potassium supplementation reversed. Potassium 138-147 insulin Homo sapiens 48-55 28926857-8 2017 Moreover, after salt loading, the plasma IL-17A concentrations increased significantly (4.2+-2.1 pg/mL to 9.7+-5.1 pg/mL; P<0.01), whereas dropped considerably when dietary potassium was supplemented (9.7+-5.1 pg/mL to 2.0+-0.9 pg/mL; P<0.001). Potassium 176-185 interleukin 17A Homo sapiens 41-47 28926857-9 2017 Statistically significant correlations were found between changes in HOMA-IR and changes in plasma IL-17A concentrations during the interventions (low- to high-salt: r=0.642, P<0.01; high-salt to potassium supplementation: r=0.703, P<0.01). Potassium 199-208 interleukin 17A Homo sapiens 99-105 28926857-11 2017 Conclusions The amelioration of salt-loading-induced IR by potassium supplementation in participants may be related to the reduction in plasma IL-17A concentration. Potassium 59-68 interleukin 17A Homo sapiens 143-149 28666963-9 2017 Overall, our results suggest that the replacement of a negatively charged residue with a positively charged lysine at position 283 in Kv1.1 causes a drop of potassium current that likely accounts for EA-1 symptoms in the heterozygous carrier. Potassium 157-166 potassium voltage-gated channel subfamily A member 1 Homo sapiens 134-139 28666963-9 2017 Overall, our results suggest that the replacement of a negatively charged residue with a positively charged lysine at position 283 in Kv1.1 causes a drop of potassium current that likely accounts for EA-1 symptoms in the heterozygous carrier. Potassium 157-166 potassium voltage-gated channel subfamily A member 1 Homo sapiens 200-204 28771277-4 2017 At baseline, the prothrombin mutation group formed denser clots (Ks -12 %, p=0.0006) and had impaired fibrinolysis (CLT +14 %, p=0.004, and CLT-TAFI +13 %, p=0.03) compared with the no mutation group and were similar to those observed in 15 healthy unrelated prothrombin mutation carriers. Potassium 65-67 coagulation factor II, thrombin Homo sapiens 17-28 28289184-0 2017 Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. Potassium 97-106 neural precursor cell expressed, developmentally down-regulated gene 4-like Mus musculus 39-46 28877665-5 2017 As 14-3-3 proteins are key regulators of signal transduction processes, we investigated the effect of deletion of the 14-3-3 genes BMH1 or BMH2 on gene expression during potassium starvation and focused especially on the expression of genes involved in phosphate uptake. Potassium 170-179 14-3-3 family protein BMH1 Saccharomyces cerevisiae S288C 131-135 28861073-6 2017 Cells detect changes in potassium level as a Danger-associated molecular pattern associated with cell damage and induce BPI expression in a p38 dependent manner. Potassium 24-33 bactericidal permeability increasing protein Homo sapiens 120-123 28779175-2 2017 Potassium efflux and mitochondrial damage are both reported to mediate NLRP3 inflammasome activation, but the underlying, orchestrating signaling events are still unclear. Potassium 0-9 NLR family pyrin domain containing 3 Homo sapiens 71-76 28779175-3 2017 Here we show that chloride intracellular channels (CLIC) act downstream of the potassium efflux-mitochondrial reactive oxygen species (ROS) axis to promote NLRP3 inflammasome activation. Potassium 79-88 NLR family pyrin domain containing 3 Homo sapiens 156-161 28779175-4 2017 NLRP3 agonists induce potassium efflux, which causes mitochondrial damage and ROS production. Potassium 22-31 NLR family pyrin domain containing 3 Homo sapiens 0-5 28824688-0 2017 Induction of Barley Silicon Transporter HvLsi1 and HvLsi2, increased silicon concentration in the shoot and regulated Starch and ABA Homeostasis under Osmotic stress and Concomitant Potassium Deficiency. Potassium 182-191 HvLsi1 Hordeum vulgare 40-46 28824688-0 2017 Induction of Barley Silicon Transporter HvLsi1 and HvLsi2, increased silicon concentration in the shoot and regulated Starch and ABA Homeostasis under Osmotic stress and Concomitant Potassium Deficiency. Potassium 182-191 HvLsi2 Hordeum vulgare 51-57 28762967-8 2017 It also occurred that the potassium cation, quite uniformly coordinated by seven O atoms from all molecular fragments of the UMPH- anion, including the O atom from the ribofuranose ring, can be treated as spherical in the charge density model which was supported by theoretical calculations. Potassium 26-35 5'-nucleotidase, cytosolic IIIA Homo sapiens 125-129 28515174-1 2017 The thiazide-sensitive sodium chloride cotransporter NCC is important for maintaining serum sodium (Na+) and, indirectly, serum potassium (K+) levels. Potassium 128-137 solute carrier family 12 member 3 Homo sapiens 53-56 28338826-6 2017 Ka/Ks ratios revealed that both chloroplast and nuclear rps16 copies were under purifying selection. Potassium 3-5 ribosomal protein S16 Homo sapiens 56-61 28684627-6 2017 Depolarization with high extracellular potassium evokes Dpp release. Potassium 39-48 decapentaplegic Drosophila melanogaster 56-59 28620664-0 2017 Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions. Potassium 129-138 Tat Human immunodeficiency virus 1 75-78 28233402-1 2017 KCNE1 is known to modulate the voltage-gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents. Potassium 45-54 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 28233402-1 2017 KCNE1 is known to modulate the voltage-gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents. Potassium 45-54 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 77-82 28389699-7 2017 This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause. Potassium 236-245 hephaestin Homo sapiens 123-127 28389699-7 2017 This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause. Potassium 236-245 potassium two pore domain channel subfamily K member 18 Homo sapiens 181-187 28586097-7 2017 For example, two homologs of the MYB transcription factor genes MYB48 and MYB59 showed differential alternative splicing only in response to low levels of potassium. Potassium 155-164 myb domain protein 48 Arabidopsis thaliana 64-69 28586097-7 2017 For example, two homologs of the MYB transcription factor genes MYB48 and MYB59 showed differential alternative splicing only in response to low levels of potassium. Potassium 155-164 myb domain protein 59 Arabidopsis thaliana 74-79 28657100-0 2017 Nanocrystalline SnS2 coated onto reduced graphene oxide: demonstrating the feasibility of a non-graphitic anode with sulfide chemistry for potassium-ion batteries. Potassium 139-148 sodium voltage-gated channel alpha subunit 11 Homo sapiens 16-20 28687778-4 2017 Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values. Potassium 147-149 infA Panax ginseng 94-98 28687778-4 2017 Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values. Potassium 147-149 rpl22 Panax ginseng 100-105 28687778-4 2017 Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values. Potassium 147-149 rps19 Panax ginseng 107-112 28687778-4 2017 Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values. Potassium 216-218 infA Panax ginseng 94-98 28687778-4 2017 Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values. Potassium 216-218 rps19 Panax ginseng 107-112 29744188-9 2017 An increase of extracellular potassium ions (K+) inhibited the secretion of IL-1ss and IL-18 (p = .008). Potassium 29-38 interleukin 18 Homo sapiens 87-92 28395223-3 2017 Gamma spectrometric measurements were performed and it was dawn on the compounds which have low density, low molecular weight and high potassium abundance showed higher 40K activity concentration. Potassium 135-144 small nuclear ribonucleoprotein U5 subunit 40 Homo sapiens 169-172 28656556-10 2017 One observed the significant positive correlation of ACP with pH of soil and contents of potassium and magnesium and negative with contents of phosphorus and organic carbon. Potassium 89-98 acid phosphatase Zea mays 53-56 28469002-9 2017 Here, we demonstrate that NPY directly inhibited a subset of ventral tegmental area (VTA) dopamine neurons through the activation of G protein-coupled inwardly rectifying potassium currents, and it inhibited both excitatory postsynaptic currents and inhibitory postsynaptic currents onto subsets of dopamine neurons through a presynaptic mechanism. Potassium 171-180 neuropeptide Y Mus musculus 26-29 28398517-10 2017 Based on these studies, we propose that the chloride influx mediated by GlialCAM/MLC1/ClC-2 in astrocytes may be needed to compensate an excess of potassium, as occurs in conditions of high neuronal activity. Potassium 147-156 hepatocyte cell adhesion molecule Mus musculus 72-80 28398517-10 2017 Based on these studies, we propose that the chloride influx mediated by GlialCAM/MLC1/ClC-2 in astrocytes may be needed to compensate an excess of potassium, as occurs in conditions of high neuronal activity. Potassium 147-156 megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Mus musculus 81-85 28398517-10 2017 Based on these studies, we propose that the chloride influx mediated by GlialCAM/MLC1/ClC-2 in astrocytes may be needed to compensate an excess of potassium, as occurs in conditions of high neuronal activity. Potassium 147-156 chloride channel, voltage-sensitive 2 Mus musculus 86-91 28374413-5 2017 These beneficial effects of leptin involve restoration of action potential duration via normalization of transient outward potassium current and sarcoplasmic reticulum Ca2+ content via rescue of control sarcoplasmic/endoplasmic reticulum Ca2+ ATPase levels and ryanodine receptor function modulation, leading to normalization of Ca2+ handling parameters. Potassium 123-132 leptin Mus musculus 28-34 28558283-6 2017 Salt stress decreases the activities of antioxidant enzymes (superoxide dismutase, catalase and ascorbate peroxidase) while the exogenous application of potassium and zinc significantly enhanced the activities of these enzymes. Potassium 153-162 catalase-1 Triticum aestivum 83-91 28558283-6 2017 Salt stress decreases the activities of antioxidant enzymes (superoxide dismutase, catalase and ascorbate peroxidase) while the exogenous application of potassium and zinc significantly enhanced the activities of these enzymes. Potassium 153-162 peroxidase-like Triticum aestivum 106-116 28461216-0 2017 Disruption of KV2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. Potassium 83-92 potassium voltage-gated channel subfamily B member 1 Rattus norvegicus 14-19 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 tumor necrosis factor Homo sapiens 282-291 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 interleukin 6 Homo sapiens 323-327 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 defensin beta 103B Homo sapiens 364-379 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 defensin beta 103B Homo sapiens 381-386 28600547-5 2017 Further, we tested the role of SUR1 in response to different potassium levels and found that dysfunction of SUR1 decreased the insulin secretion rate in low and high potassium environments. Potassium 61-70 ATP binding cassette subfamily C member 8 Homo sapiens 31-35 28600547-5 2017 Further, we tested the role of SUR1 in response to different potassium levels and found that dysfunction of SUR1 decreased the insulin secretion rate in low and high potassium environments. Potassium 61-70 ATP binding cassette subfamily C member 8 Homo sapiens 108-112 28600547-5 2017 Further, we tested the role of SUR1 in response to different potassium levels and found that dysfunction of SUR1 decreased the insulin secretion rate in low and high potassium environments. Potassium 166-175 ATP binding cassette subfamily C member 8 Homo sapiens 108-112 27927653-7 2017 Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. Potassium 5-14 adducin 3 Rattus norvegicus 116-120 27913567-4 2017 We have identified the potassium-sparing diuretic drug triamterene, as a novel sensitizing agent in MMR-deficient tumor cells, in vitro and in vivoResults: The selective tumor cell cytotoxicity of triamterene occurs through its antifolate activity and depends on the activity of the folate synthesis enzyme thymidylate synthase. Potassium 23-32 thymidylate synthetase Homo sapiens 307-327 28052988-0 2017 Potassium Sensing by Renal Distal Tubules Requires Kir4.1. Potassium 0-9 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 51-57 28322742-12 2017 In vivo electrophysiological intracellular recordings of individual spinal motoneurones revealed that central potassium channel function was preserved or even enhanced with higher amplitude and longer duration after-hyperpolarisations in the G127X SOD1 mice. Potassium 110-119 superoxide dismutase 1, soluble Mus musculus 248-252 28052988-5 2017 Here, we tested the hypothesis that the potassium channel Kir4.1 is the potassium sensor of DCT cells. Potassium 40-49 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 58-64 28052988-7 2017 Deletion of Kir4.1 in these mice led to moderate salt wasting, low BP, and profound potassium wasting. Potassium 84-93 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 12-18 28052988-10 2017 Together, these results indicate that Kir4.1 mediates potassium sensing by DCT cells and couples this signal to apical transport processes. Potassium 54-63 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 38-44 28098344-4 2017 Moreover, we demonstrated that RXFP3 activation induces a cadmium-sensitive outward current, which indicates the involvement of a characteristic magnocellular neuron outward potassium current. Potassium 174-183 relaxin family peptide receptor 3 Rattus norvegicus 31-36 28187982-0 2017 The renal TRPV4 channel is essential for adaptation to increased dietary potassium. Potassium 73-82 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 10-15 28187982-4 2017 Here, we demonstrate that elevated dietary potassium intake (five percent potassium) increases renal TRPV4 mRNA and protein levels in an aldosterone-dependent manner and causes redistribution of the channel to the apical plasma membrane in native collecting duct cells. Potassium 43-52 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 101-106 28187982-4 2017 Here, we demonstrate that elevated dietary potassium intake (five percent potassium) increases renal TRPV4 mRNA and protein levels in an aldosterone-dependent manner and causes redistribution of the channel to the apical plasma membrane in native collecting duct cells. Potassium 74-83 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 101-106 28187982-5 2017 This, in turn, leads to augmented TRPV4-mediated flow-dependent calcium ion responses in freshly isolated split-opened collecting ducts from mice fed the high potassium diet. Potassium 159-168 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 34-39 28187982-6 2017 Genetic TRPV4 ablation greatly diminished BK channel activity in collecting duct cells pointing to a reduced capacity to excrete potassium. Potassium 129-138 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 8-13 28187982-7 2017 Consistently, elevated potassium intake induced hyperkalemia in TRPV4 knockout mice due to deficient renal potassium excretion. Potassium 23-32 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 64-69 28187982-7 2017 Consistently, elevated potassium intake induced hyperkalemia in TRPV4 knockout mice due to deficient renal potassium excretion. Potassium 107-116 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 64-69 28187982-8 2017 Thus, regulation of TRPV4 activity in the distal nephron by dietary potassium is an indispensable component of whole body potassium balance. Potassium 68-77 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 20-25 28187982-8 2017 Thus, regulation of TRPV4 activity in the distal nephron by dietary potassium is an indispensable component of whole body potassium balance. Potassium 122-131 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 20-25 28558783-3 2017 KS-IRIS was defined as >=2 of the following: abrupt increase in number of KS lesions, appearance or exacerbation of lung-opacities or lymphedema, concomitantly with an increase in CD4+ cell-count >=50 cells/mm3 and a decrease of >1 log in viral-load once started cART. Potassium 0-2 CD4 molecule Homo sapiens 183-186 28579824-4 2017 Here, using cultured DH neurons, we have shown that tumor necrosis factor-alpha inhibits the total outward potassium current IK and the KNa current predominantly as well as induces a progressive loss of firing accommodation. Potassium 107-116 tumor necrosis factor Rattus norvegicus 52-79 28596754-7 2017 In conclusion, mutant huntingtin-expressing cells showed a negligible effect of Ang II on potassium current, a result probably due to the reduced expression of AT1 receptors at the surface cell membrane. Potassium 90-99 huntingtin Mus musculus 22-32 28560099-8 2017 Moreover, the overall mean serum potassium concentration was significantly lower in the ACTH versus the non-ACTH group (3.34 mmol/L vs. 3.79 mmol/L, P = 0.001). Potassium 33-42 proopiomelanocortin Homo sapiens 88-92 28560099-8 2017 Moreover, the overall mean serum potassium concentration was significantly lower in the ACTH versus the non-ACTH group (3.34 mmol/L vs. 3.79 mmol/L, P = 0.001). Potassium 33-42 proopiomelanocortin Homo sapiens 108-112 28560099-10 2017 CONCLUSIONS: ACTH-pituitary adenomas may be an independent factor related postoperative hypokalemia in patients despite conventional potassium supplementation in the immediate postoperative period. Potassium 133-142 proopiomelanocortin Homo sapiens 13-17 28288868-2 2017 Particularly, Kir4.1 channels are involved in the astroglial spatial potassium buffering. Potassium 69-78 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 14-20 28288868-7 2017 Overall, this study shows that quinacrine blocks Kir4.1 channels, which would be expected to impact the potassium transport in several tissues. Potassium 104-113 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 49-55 28472061-3 2017 Ion currents from TRPM8 expressing trigeminal ganglion (TRG) neurons in females demonstrated larger hyperpolarization-activated cyclic nucleotide-gated currents (Ih) than male neurons at both 30 and 18 C. Additionally, female neurons" voltage gated potassium currents (Ik) were suppressed by cooling, whereas male Ik was not significantly affected. Potassium 250-259 transient receptor potential cation channel, subfamily M, member 8 Mus musculus 18-23 28596754-8 2017 In contrast, administration of Ang (1-7) to the bath showed a significant decline of the potassium current in mutant cells, an effect dependent on the activation of Mas receptors. Potassium 89-98 angiogenin, ribonuclease, RNase A family, 5 Mus musculus 31-34 28575882-11 2017 The ACE genotype correlated with QT dispersion, corrected QT dispersion, hemoglobin, and residual urine, and inversely correlated with serum potassium. Potassium 141-150 angiotensin I converting enzyme Homo sapiens 4-7 28593901-8 2017 Sequence analysis of the CUL3 gene demonstrated a previously unreported heterozygous c.1377+2T>3 mutation, confirming the diagnosis of PHAII-E. We highlight the importance of the determination of plasma aldosterone and plasma renin activity in the context of persistent sodium and potassium imbalances in children. Potassium 284-293 cullin 3 Homo sapiens 25-29 28094030-4 2017 Here we provide evidence supporting a role for GILZ in modulating the balance of renal sodium and potassium excretion by regulating the sodium-chloride cotransporter (NCC) activity in the distal nephron. Potassium 98-107 TSC22 domain family, member 3 Mus musculus 47-51 28094030-5 2017 Gilz-/- mice have a higher plasma potassium concentration and lower fractional excretion of potassium than wild type mice. Potassium 34-43 TSC22 domain family, member 3 Mus musculus 0-4 28094030-5 2017 Gilz-/- mice have a higher plasma potassium concentration and lower fractional excretion of potassium than wild type mice. Potassium 92-101 TSC22 domain family, member 3 Mus musculus 0-4 28094030-11 2017 Thus, GILZ promotes potassium secretion by inhibiting NCC and enhancing distal sodium delivery to the epithelial sodium channel. Potassium 20-29 TSC22 domain family, member 3 Mus musculus 6-10 28457217-10 2017 A positive correlation was determined between the saliva fetuin-A levels and the saliva phosphorus and potassium levels of the patients ( P = .04, P = .02). Potassium 103-112 alpha 2-HS glycoprotein Homo sapiens 57-65 27987209-0 2017 The sodium transporter encoded by the HKT1;2 gene modulates sodium/potassium homeostasis in tomato shoots under salinity. Potassium 67-76 sodium transporter HKT1,2 Solanum lycopersicum 38-44 28419159-12 2017 Compared to placebo, potassium supplementation resulted in modest but significant reductions in both SBP (MD -4.25 mmHg; 95% CI: -5.96 to -2.53; I2 = 41%) and DBP (MD -2.53 mmHg; 95% CI: -4.05 to -1.02; I2 = 65%). Potassium 21-30 selenium binding protein 1 Homo sapiens 101-104 28419159-12 2017 Compared to placebo, potassium supplementation resulted in modest but significant reductions in both SBP (MD -4.25 mmHg; 95% CI: -5.96 to -2.53; I2 = 41%) and DBP (MD -2.53 mmHg; 95% CI: -4.05 to -1.02; I2 = 65%). Potassium 21-30 D-box binding PAR bZIP transcription factor Homo sapiens 159-162 28320163-0 2017 Inhibition of 17-beta-estradiol on neuronal excitability via enhancing GIRK1-mediated inwardly rectifying potassium currents and GIRK1 expression. Potassium 106-115 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens 71-76 28420122-0 2017 The Effect of Salt Intake and Potassium Supplementation on Serum Gastrin Levels in Chinese Adults: A Randomized Trial. Potassium 30-39 gastrin Homo sapiens 65-72 28218507-6 2017 The developed potassium ISE displays a wide linear sensing range (0.01-100 mM), a low detection limit (7 muM), minimal drift (8.6 x 10-6 V/s), and a negligible interference during electrochemical potassium sensing against the backdrop of interfering ions [i.e., sodium (Na), magnesium (Mg), and calcium (Ca)] and artificial eccrine perspiration. Potassium 14-23 latexin Homo sapiens 105-108 28420122-4 2017 The aim of our study was to assess the effects of altered salt and potassium supplementation on serum gastrin levels in humans. Potassium 67-76 gastrin Homo sapiens 102-109 28420122-11 2017 The present study indicated that variations in dietary salt and potassium supplementation affected the serum gastrin concentrations in the Chinese subjects. Potassium 64-73 gastrin Homo sapiens 109-116 28164279-7 2017 Calcipotriol significantly decreased the frequency of alpha-synuclein aggregate positive cells subjected to treatments that cause raised intracellular-free Ca(II) (potassium depolarization, KCl/H2 O2 combined treatment, and rotenone) in a dose-dependent manner and increased viability. Potassium 164-173 synuclein alpha Homo sapiens 54-69 27902841-8 2017 In cardiac myocytes, there are several Ca2+ -sensitive potassium (K+ ) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca2+ -activated potassium (SK) current (ISK ). Potassium 55-64 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 209-212 28298088-4 2017 Moreover, the potential signals of the IS-TGT for sodium and potassium ions, which are usually included in biological environments, were evaluated. Potassium 61-70 queuine tRNA-ribosyltransferase catalytic subunit 1 Homo sapiens 42-45 28185290-14 2017 This agreement holds for both loss-of-function and gain-of-function mutations in the HCN4, SCN5A and KCNQ1 genes, underlying ion channelopathies in If , fast sodium current and slow delayed rectifier potassium current, respectively. Potassium 200-209 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Homo sapiens 85-89 27997067-0 2017 Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of alpha-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum. Potassium 36-45 synuclein alpha Homo sapiens 97-112 28131627-1 2017 Inward rectifying potassium - Kir - channels drive the resting potential to potassium reversal potential and, when disrupted, might be related to muscular diseases. Potassium 18-27 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 30-33 28327612-5 2017 Postsynaptically, the opioids activate a potassium conductance through the mu-opioid receptor (MOR), suggesting for the first time that endogenously released opioids directly regulate neuronal excitability. Potassium 41-50 opioid receptor mu 1 Homo sapiens 75-93 28327612-5 2017 Postsynaptically, the opioids activate a potassium conductance through the mu-opioid receptor (MOR), suggesting for the first time that endogenously released opioids directly regulate neuronal excitability. Potassium 41-50 opioid receptor mu 1 Homo sapiens 95-98 28262710-1 2017 The distribution of potassium (K+) ions on air-cleaved mica is important in many interfacial phenomena such as crystal growth, self-assembly and charge transfer on mica. Potassium 20-29 MHC class I polypeptide-related sequence A Homo sapiens 55-59 28262710-1 2017 The distribution of potassium (K+) ions on air-cleaved mica is important in many interfacial phenomena such as crystal growth, self-assembly and charge transfer on mica. Potassium 20-29 MHC class I polypeptide-related sequence A Homo sapiens 164-168 28273873-6 2017 CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. Potassium 86-95 C-terminal Src kinase Homo sapiens 0-3 28273873-6 2017 CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. Potassium 86-95 C-terminal Src kinase Homo sapiens 18-21 28273873-6 2017 CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. Potassium 86-95 microRNA 4513 Homo sapiens 22-29 28273873-8 2017 The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Potassium 214-223 C-terminal Src kinase Homo sapiens 63-66 28273873-8 2017 The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Potassium 214-223 C-terminal Src kinase Homo sapiens 81-84 28273873-8 2017 The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Potassium 214-223 microRNA 4513 Homo sapiens 85-92 28042949-6 2017 KS-IMM cells infected by Chi-H1/CXCL4L1 or Chi-H1/CXCL10 released the corresponding chemokine and showed reduced migratory capacity. Potassium 0-2 platelet factor 4 variant 1 Homo sapiens 32-39 28042949-6 2017 KS-IMM cells infected by Chi-H1/CXCL4L1 or Chi-H1/CXCL10 released the corresponding chemokine and showed reduced migratory capacity. Potassium 0-2 C-X-C motif chemokine ligand 10 Homo sapiens 50-56 28042949-10 2017 Further experiments indicated that CXCL4L1 and CXCL10 interfered with the expression of the viral NS1 protein in KS-IMM cells. Potassium 113-115 platelet factor 4 variant 1 Homo sapiens 35-42 28042949-10 2017 Further experiments indicated that CXCL4L1 and CXCL10 interfered with the expression of the viral NS1 protein in KS-IMM cells. Potassium 113-115 C-X-C motif chemokine ligand 10 Homo sapiens 47-53 28042949-10 2017 Further experiments indicated that CXCL4L1 and CXCL10 interfered with the expression of the viral NS1 protein in KS-IMM cells. Potassium 113-115 influenza virus NS1A binding protein Homo sapiens 98-101 28122887-4 2017 Mutations in the anosmin-1 (ANOS1) gene are responsible for the X-linked recessive form of KS. Potassium 91-93 anosmin 1 Homo sapiens 17-26 28122887-4 2017 Mutations in the anosmin-1 (ANOS1) gene are responsible for the X-linked recessive form of KS. Potassium 91-93 anosmin 1 Homo sapiens 28-33 28130493-4 2017 MLKL activation triggers potassium efflux and assembly of the NLRP3 inflammasome, which is required for the processing and activity of IL-1beta released during necroptosis. Potassium 25-34 mixed lineage kinase domain like pseudokinase Homo sapiens 0-4 28130493-4 2017 MLKL activation triggers potassium efflux and assembly of the NLRP3 inflammasome, which is required for the processing and activity of IL-1beta released during necroptosis. Potassium 25-34 interleukin 1 beta Homo sapiens 135-143 28012096-1 2017 The voltage gated sodium channel SCN4A mutations account for non-dystrophic myotonia and include a heterogeneous group of conditions that include hyperkalemic periodic paralysis, paramyotonica congenita, potassium-aggravated myotonia, and hypokalemic periodic paralysis type 2. Potassium 204-213 sodium voltage-gated channel alpha subunit 4 Homo sapiens 33-38 27856205-8 2017 These results suggest that upregulation of the ROMK channel in apical cells might permit avid potassium flux into the bladder lumen to maintain intracellular K+ homeostasis in the dysfunctional urothelium. Potassium 94-103 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 47-51 27939864-2 2017 Serum potassium should be investigated in patients developing chronic or frequent vomiting or diarrhea, marked polyuria, muscle weakness, or unexpected cardiac arrhythmias, as well as in those undergoing therapy with insulin, diuretics, or total parenteral nutrition. Potassium 6-15 insulin Homo sapiens 217-224 28119399-8 2017 The effect of cross-linked 300 kDa on potassium current was reduced by removing Na+ from the bath solution, or by knocking down levels of Slack using siRNA. Potassium 38-47 slack Aplysia californica 138-143 28193246-4 2017 The same KvLQT1/KCNE1 channel complex is expressed in the inner ear and essential for luminal potassium secretion into the endolymphatic space. Potassium 94-103 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 9-15 28193246-4 2017 The same KvLQT1/KCNE1 channel complex is expressed in the inner ear and essential for luminal potassium secretion into the endolymphatic space. Potassium 94-103 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 28096356-4 2017 Here, we provide evidence that MLKL-induced activation of NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and association of MLKL with cellular membranes, and (iii) a reduction in intracellular potassium concentration. Potassium 234-243 mixed lineage kinase domain like pseudokinase Homo sapiens 31-35 28096356-4 2017 Here, we provide evidence that MLKL-induced activation of NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and association of MLKL with cellular membranes, and (iii) a reduction in intracellular potassium concentration. Potassium 234-243 NLR family pyrin domain containing 3 Homo sapiens 58-63 28096356-4 2017 Here, we provide evidence that MLKL-induced activation of NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and association of MLKL with cellular membranes, and (iii) a reduction in intracellular potassium concentration. Potassium 234-243 mixed lineage kinase domain like pseudokinase Homo sapiens 119-123 28096356-4 2017 Here, we provide evidence that MLKL-induced activation of NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and association of MLKL with cellular membranes, and (iii) a reduction in intracellular potassium concentration. Potassium 234-243 mixed lineage kinase domain like pseudokinase Homo sapiens 119-123 27506492-3 2017 Here we show that LPS application to hippocampal slices markedly enhances the excitability of CA1 pyramidal cells by inhibiting a specific potassium current, the M-current, generated by KV 7/M channels, which controls the excitability of almost every neuron in the CNS. Potassium 139-148 carbonic anhydrase 1 Homo sapiens 94-97 27842238-1 2017 Classical modes of NLRP3 activation entail a priming step that enables its activation (signal 1) and a potassium efflux-dependent activation signal (signal 2) that triggers pyroptosome formation and pyroptosis, a lytic cell death necessary for IL-1beta release. Potassium 103-112 NLR family pyrin domain containing 3 Homo sapiens 19-24 27835032-10 2017 After adjusting for covariates, SBP and DBP and creatinine levels were independently associated with 24 hours urinary [Na+]/[K+] Conclusion: These findings suggest that pregnant with PE with high dietary salt and low potassium intake may have greater maternal and neonatal morbidity risk than pregnant with PE under low dietary salt and high potassium intake. Potassium 342-351 selenium binding protein 1 Homo sapiens 32-35 27920129-1 2017 The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na+/K+/2Cl- cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 37-41 28321294-11 2017 Moreover, this study confirms the importance of potassium dosage when screening the renin-angiotensin-aldosterone system. Potassium 48-57 renin Homo sapiens 84-89 27562026-1 2017 KEY POINTS: Kv2 channels underlie delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Potassium 52-61 potassium voltage-gated channel subfamily A member 6 Rattus norvegicus 12-15 28017718-0 2017 Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2). Potassium 79-88 amyloid beta precursor protein Rattus norvegicus 33-58 28017718-0 2017 Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2). Potassium 79-88 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Rattus norvegicus 163-167 28017718-4 2017 Interestingly, one of the purified proteins was potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2), which has been shown to be involved in epilepsy. Potassium 48-57 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Rattus norvegicus 132-136 28135564-4 2017 The accumulation of extremely large amounts of GFAP causes many molecular changes in astrocytes, including proteasome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss of glutamate and potassium buffering capacity, loss of astrocyte coupling, and changes in cell morphology. Potassium 229-238 glial fibrillary acidic protein Homo sapiens 47-51 27823598-8 2017 Patients with high potassium more often used angiotensin-converting enzyme inhibitors and mineralocorticoid receptor antagonists before admission, had impaired baseline renal function and a better diuretic response (p = 0.005), independent of mineralocorticoid receptor antagonist usage. Potassium 19-28 nuclear receptor subfamily 3 group C member 2 Homo sapiens 90-116 27823598-8 2017 Patients with high potassium more often used angiotensin-converting enzyme inhibitors and mineralocorticoid receptor antagonists before admission, had impaired baseline renal function and a better diuretic response (p = 0.005), independent of mineralocorticoid receptor antagonist usage. Potassium 19-28 nuclear receptor subfamily 3 group C member 2 Homo sapiens 243-269 28551790-3 2017 Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is important for mitochondrial function in terms of oxygen consumption and potassium fluxes. Potassium 188-197 gap junction protein alpha 1 Homo sapiens 52-56 27895122-2 2017 Among the major determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases. Potassium 32-41 Trk1p Saccharomyces cerevisiae S288C 104-108 27895122-2 2017 Among the major determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases. Potassium 32-41 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 176-180 27895122-2 2017 Among the major determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases. Potassium 32-41 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 182-186 27895122-2 2017 Among the major determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases. Potassium 32-41 protein kinase HAL5 Saccharomyces cerevisiae S288C 192-196 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 serine/threonine protein kinase NPR1 Saccharomyces cerevisiae S288C 71-75 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 serine/threonine protein kinase SCH9 Saccharomyces cerevisiae S288C 111-115 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 117-121 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 protein kinase HAL5 Saccharomyces cerevisiae S288C 122-126 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 Trk1p Saccharomyces cerevisiae S288C 131-135 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 36-45 Trk2p Saccharomyces cerevisiae S288C 136-140 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 231-240 serine/threonine protein kinase NPR1 Saccharomyces cerevisiae S288C 71-75 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 231-240 serine/threonine protein kinase SCH9 Saccharomyces cerevisiae S288C 111-115 27895122-6 2017 Specifically, growth under limiting potassium alters the activities of Npr1 and another TORC1 effector kinase, Sch9; hal4 hal5 and trk1 trk2 mutants display hypersensitivity to rapamycin, and reciprocally, TORC1 inhibition reduces potassium accumulation. Potassium 231-240 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 117-121 28164127-5 2017 The apical membrane expression, where NKCC2 is functional, may be sufficient to normalize water, potassium, sodium, and osmolytes tubular handling. Potassium 97-106 solute carrier family 12 member 1 Rattus norvegicus 38-43 28164127-8 2017 These data suggest that the upregulation in the expression of NKCC2 in apical membranes during the postobstructive phase of BUO could contribute to improving the excretion of sodium and consequently also the excretion of potassium, osmolytes, and water. Potassium 221-230 solute carrier family 12 member 1 Rattus norvegicus 62-67 27816553-3 2017 Additionally, OAA inhibited serum and potassium deprivation-induced caspase 3 activation. Potassium 38-47 caspase 3 Homo sapiens 68-77 28073850-1 2017 BACKGROUND: Heart failure guidelines recommend routine monitoring of serum potassium, and renal function in patients treated with a mineralocorticoid receptor antagonist (MRA). Potassium 75-84 nuclear receptor subfamily 3 group C member 2 Homo sapiens 132-158 28158516-1 2017 Aims: Diuretics and renin-angiotensin-aldosterone system inhibitors are central in the treatment of hypertension, but may cause serum potassium abnormalities. Potassium 134-143 renin Homo sapiens 20-25 28714415-3 2017 The interactions of AQP4 are as follows: (i) AQP4 could influence astrocytic calcium signaling and potassium homeostasis. Potassium 99-108 aquaporin 4 Homo sapiens 20-24 28714415-3 2017 The interactions of AQP4 are as follows: (i) AQP4 could influence astrocytic calcium signaling and potassium homeostasis. Potassium 99-108 aquaporin 4 Homo sapiens 45-49 27830577-6 2017 Orexin peptides excite other arousal-promoting neurons (noradrenaline, histamine, serotonin, acetylcholine neurons), either by activating mixed-cation conductances or by inhibiting potassium conductances. Potassium 181-190 hypocretin neuropeptide precursor Homo sapiens 0-6 27147508-6 2017 There were increased caspase -3, -8 and -9 activities when fibroblasts were treated with 0.4, 0.8 and 1.6 muM CdCl2 for 24 h. Higher intracellular calcium (Ca2+) and reactive oxygen species (ROS) levels, and enhanced efflux of extracellular Ca2+ and potassium (K+). Potassium 250-259 caspase 3 Mus musculus 21-42 28286812-0 2017 20-Day Trend of Serum Potassium Changes in Bam Earthquake Victims with Crush Syndrome; a Cross-sectional Study. Potassium 22-31 structural maintenance of chromosomes 3 Homo sapiens 43-46 28286812-2 2017 The present study aimed to evaluate the trend of potassium changes in crush syndrome patients of Bam earthquake. Potassium 49-58 structural maintenance of chromosomes 3 Homo sapiens 97-100 28286812-3 2017 METHODS: In this retrospective cross-sectional study, using the database of Bam earthquake victims, which were developed by Iranian Society of Nephrology following Bam earthquake, Iran, 2003, the 20-day trend of potassium changes in > 15 years old crush syndrome patients was evaluated. Potassium 212-221 structural maintenance of chromosomes 3 Homo sapiens 76-79 28286812-3 2017 METHODS: In this retrospective cross-sectional study, using the database of Bam earthquake victims, which were developed by Iranian Society of Nephrology following Bam earthquake, Iran, 2003, the 20-day trend of potassium changes in > 15 years old crush syndrome patients was evaluated. Potassium 212-221 structural maintenance of chromosomes 3 Homo sapiens 164-167 27481527-1 2017 Connexin 26 (Cx-26), a gap junction protein coded by GJB2 gene, plays a very important role in recycling of potassium ions, one of the vital steps in the mechanotransduction process of hearing. Potassium 108-117 gap junction protein beta 2 Homo sapiens 0-11 27481527-1 2017 Connexin 26 (Cx-26), a gap junction protein coded by GJB2 gene, plays a very important role in recycling of potassium ions, one of the vital steps in the mechanotransduction process of hearing. Potassium 108-117 gap junction protein beta 2 Homo sapiens 13-18 27481527-1 2017 Connexin 26 (Cx-26), a gap junction protein coded by GJB2 gene, plays a very important role in recycling of potassium ions, one of the vital steps in the mechanotransduction process of hearing. Potassium 108-117 gap junction protein beta 2 Homo sapiens 53-57 28177101-9 2017 Serum potassium values were significantly higher in patients treated with both ACE/ARB and antialdosterone drugs. Potassium 6-15 angiotensin I converting enzyme Homo sapiens 79-82 28367274-0 2017 Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons. Potassium 34-43 AKT serine/threonine kinase 1 Homo sapiens 85-88 28367274-0 2017 Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons. Potassium 34-43 thioredoxin interacting protein Homo sapiens 118-123 27966362-1 2016 Na+/K+-ATPase (NKA) is an essential cation pump protein responsible for the maintenance of the sodium and potassium gradients across the plasma membrane. Potassium 106-115 tachykinin precursor 1 Homo sapiens 0-13 27966362-1 2016 Na+/K+-ATPase (NKA) is an essential cation pump protein responsible for the maintenance of the sodium and potassium gradients across the plasma membrane. Potassium 106-115 tachykinin precursor 1 Homo sapiens 15-18 27867157-4 2016 Our study was designed to examine the effects of salt intake and potassium supplementation on plasma OPG levels in normotensive subjects.Methods and Results:The 18 normotensive subjects were selected from a rural community in China. Potassium 65-74 TNF receptor superfamily member 11b Homo sapiens 101-104 27867157-9 2016 By contrast, OPG concentration negatively correlated with 24-h urinary potassium excretion (r=0.594, P<0.01). Potassium 71-80 TNF receptor superfamily member 11b Homo sapiens 13-16 27867157-11 2016 Potassium supplementation can reverse the effects of excessive OPG. Potassium 0-9 TNF receptor superfamily member 11b Homo sapiens 63-66 28006004-6 2016 Inhibition of Na+/K+ ATPase by an alternative approach (removal of extracellular potassium) had a similar effect in HLF. Potassium 81-90 HLF transcription factor, PAR bZIP family member Homo sapiens 116-119 27789381-2 2016 The TWIK-related spinal cord K+ (TRESK) is the major background potassium current in dorsal root ganglia (DRG), we found that mitogen-activated protein kinase (MAPK) signal pathway were activated in spinal cord accompanied by TRESK down regulation in response to NP. Potassium 64-73 potassium two pore domain channel subfamily K member 1 Rattus norvegicus 4-8 27960436-7 2016 As the degree of PDI aggregation was reduced, ks,opt declined, which is attributed to a reduction in the lateral electron self-exchange rate between adsorbed PDI molecules, as well as the heterogeneous conductivity of the ITO electrode surface. Potassium 46-48 peptidyl arginine deiminase 1 Homo sapiens 17-20 27960436-7 2016 As the degree of PDI aggregation was reduced, ks,opt declined, which is attributed to a reduction in the lateral electron self-exchange rate between adsorbed PDI molecules, as well as the heterogeneous conductivity of the ITO electrode surface. Potassium 46-48 peptidyl arginine deiminase 1 Homo sapiens 158-161 28003811-10 2016 The association of potassium with risk of CD and UC appeared to be modified by loci involved in the TH17 pathway that have previously been associated with susceptibility to CD, particularly SNP rs7657746 (IL21) (Pinteraction = 0.004 and 0.01, respectively). Potassium 19-28 interleukin 21 Homo sapiens 205-209 28003811-11 2016 In vitro, potassium enhanced the expression of Foxp3 in both naive and memory CD4+ T cells via activating Smad2/3 and inhibiting Smad7 in TH17 cells. Potassium 10-19 forkhead box P3 Homo sapiens 47-52 28003811-11 2016 In vitro, potassium enhanced the expression of Foxp3 in both naive and memory CD4+ T cells via activating Smad2/3 and inhibiting Smad7 in TH17 cells. Potassium 10-19 SMAD family member 2 Homo sapiens 106-113 28003811-11 2016 In vitro, potassium enhanced the expression of Foxp3 in both naive and memory CD4+ T cells via activating Smad2/3 and inhibiting Smad7 in TH17 cells. Potassium 10-19 SMAD family member 7 Homo sapiens 129-134 27924824-4 2016 Potassium uptake from the rhizosphere is mediated mainly by KUP/HAK/KT and CNGC transporters. Potassium 0-9 zinc finger and BTB domain containing 25 Homo sapiens 60-63 27924824-4 2016 Potassium uptake from the rhizosphere is mediated mainly by KUP/HAK/KT and CNGC transporters. Potassium 0-9 alpha kinase 2 Homo sapiens 64-67 27756725-4 2016 Insulin and beta-adrenergic tone play critical roles in maintaining the internal distribution of potassium under normal conditions. Potassium 97-106 insulin Homo sapiens 0-7 27599629-6 2016 In patients with DKA and a relatively low plasma potassium level, insulin administration may cause hypokalemia and cardiac arrhythmias. Potassium 49-58 insulin Homo sapiens 66-73 27492348-3 2016 Within the QTL SI regions, 44 genes were located, and runt-related transcription factor 1, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), and potassium inwardly-rectifying channel, subfamily J, member 15 KCNJ15-which are reported to be related to the hematological traits and clinical features of Down syndrome-were selected as positional candidate genes. Potassium 171-180 potassium inwardly rectifying channel subfamily J member 15 Sus scrofa 233-239 27895227-0 2016 Phosphorylation of ARF2 Relieves Its Repression of Transcription of the K+ Transporter Gene HAK5 in Response to Low Potassium Stress. Potassium 116-125 auxin response factor 2 Arabidopsis thaliana 19-23 27895227-0 2016 Phosphorylation of ARF2 Relieves Its Repression of Transcription of the K+ Transporter Gene HAK5 in Response to Low Potassium Stress. Potassium 116-125 high affinity K+ transporter 5 Arabidopsis thaliana 92-96 27882934-4 2016 IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. Potassium 85-94 interleukin 1 beta Mus musculus 0-8 27381844-8 2017 Plasma potassium concentration strongly and negatively correlated with pNCC, NCC, and WNK4 abundance (P<0.001 for all). Potassium 7-16 WNK lysine deficient protein kinase 4 Homo sapiens 86-90 27609046-10 2016 Considering evidence from brain ischemia models, KCNK10/TREK-2 upregulation might serve a protective function with a beneficial impact on astrocytic potassium and glutamate homeostasis. Potassium 149-158 potassium two pore domain channel subfamily K member 10 Rattus norvegicus 49-55 28097003-6 2016 System-specific maximal achievable Delta QTc was estimated to 28% from baseline in both dog and human, while %hERG block leading to half-maximal effects was 58% lower in human, suggesting a higher contribution of hERG-mediated potassium current to cardiac repolarization. Potassium 227-236 ETS transcription factor ERG Homo sapiens 213-217 27852771-3 2016 KCC2 regulates intraneuronal chloride and extracellular potassium levels by extruding both ions. Potassium 56-65 solute carrier family 12 member 5 Homo sapiens 0-4 27852771-4 2016 Absence of effective KCC2 may alter the dynamics of chloride and potassium levels during repeated activation of GABAergic synapses due to interneuron activity. Potassium 65-74 solute carrier family 12 member 5 Homo sapiens 21-25 27852771-9 2016 The pyramidal cell model explicitly incorporated the cotransporter KCC2 and its effects on the internal/external chloride and potassium levels. Potassium 126-135 solute carrier family 12 member 5 Homo sapiens 67-71 27852771-10 2016 Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. Potassium 104-113 solute carrier family 12 member 5 Homo sapiens 40-44 27609046-10 2016 Considering evidence from brain ischemia models, KCNK10/TREK-2 upregulation might serve a protective function with a beneficial impact on astrocytic potassium and glutamate homeostasis. Potassium 149-158 potassium two pore domain channel subfamily K member 10 Rattus norvegicus 56-62 27829152-0 2016 A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Potassium 8-17 agouti related neuropeptide Mus musculus 29-33 27895596-1 2016 The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes. Potassium 24-33 IKAROS family zinc finger 1 Homo sapiens 43-46 27895596-6 2016 The conductances, GK1, of the inwardly rectifying potassium current, and GNa, of the fast inward sodium current were modified independently and in tandem to simulate reciprocal modulation. Potassium 50-59 glycerol kinase Homo sapiens 18-21 27895596-12 2016 Reciprocal modulation of the inwardly rectifying potassium current and the fast inward sodium current may have a functional role in allowing cardiac tissue to remain excitable when IK1 is upregulated. Potassium 49-58 IKAROS family zinc finger 1 Homo sapiens 181-184 27829152-0 2016 A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Potassium 8-17 neuropeptide Y Mus musculus 34-37 27829152-4 2016 We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Potassium 111-120 agouti related neuropeptide Mus musculus 14-18 27829152-4 2016 We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Potassium 111-120 neuropeptide Y Mus musculus 19-22 27829152-4 2016 We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Potassium 111-120 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Mus musculus 132-135 27829152-4 2016 We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Potassium 111-120 agouti related neuropeptide Mus musculus 256-260 27829152-4 2016 We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Potassium 111-120 neuropeptide Y Mus musculus 261-264 27942049-0 2016 Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3. Potassium 0-9 solute carrier family 12, member 3 Mus musculus 31-50 27942049-0 2016 Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3. Potassium 0-9 kelch-like 3 Mus musculus 112-124 27590241-4 2016 The increment of action potential duration caused by Ang-(1-12) (100 nM) was due to a decrease of total potassium current recorded from single cardiomyocytes using the whole cell configuration of pCAMP. Potassium 104-113 angiogenin Rattus norvegicus 53-56 27566292-6 2016 In contrast, knockdown of endogenous THIK-1 by RNA interference resulted in delayed shrinkage and potassium efflux. Potassium 98-107 potassium channel, two pore domain subfamily K, member 13 S homeolog Xenopus laevis 37-43 27590241-5 2016 The decrease of potassium current was related to the activation of protein kinase C (PKC) because the specific inhibitor of kinase C, Bis-1 (10-9 M), abolished Ang-(1-12) effects on the potassium current. Potassium 16-25 angiogenin Rattus norvegicus 160-163 27590241-5 2016 The decrease of potassium current was related to the activation of protein kinase C (PKC) because the specific inhibitor of kinase C, Bis-1 (10-9 M), abolished Ang-(1-12) effects on the potassium current. Potassium 186-195 angiogenin Rattus norvegicus 160-163 27590241-7 2016 Moreover, intracellular Ang II (100 nM), by itself, reduced the potassium current, an effect decreased by intracellular valsartan (100 nM). Potassium 64-73 angiogenin Rattus norvegicus 24-27 27590241-9 2016 These observations demonstrate that the effect of Ang-(1-12) on potassium current was related to the formation of Ang II and that the peptide has arrhythmogenic properties. Potassium 64-73 angiogenin Rattus norvegicus 50-53 27590241-9 2016 These observations demonstrate that the effect of Ang-(1-12) on potassium current was related to the formation of Ang II and that the peptide has arrhythmogenic properties. Potassium 64-73 angiogenin Rattus norvegicus 114-117 27779191-4 2016 Intriguingly, 25-HC, but not VLCFA, promotes robust NLRP3 inflammasome assembly and activation via potassium efflux-, mitochondrial reactive oxygen species (ROS)- and liver X receptor (LXR)-mediated pathways. Potassium 99-108 NLR family pyrin domain containing 3 Homo sapiens 52-57 27508897-5 2016 Insulin treatment increased Ks and mitochondrial protein synthesis, enhanced translation activation, and reduced SIRT1 in CON. Potassium 28-30 insulin Sus scrofa 0-7 27508897-6 2016 In contrast, in CLP, insulin treatment increased Ks, protein kinase B (PKB) and Forkhead box O1 phosphorylation, antagonized AMPK activation, and decreased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha), MuRF1, and SIRT1. Potassium 49-51 insulin Sus scrofa 21-28 27843308-6 2016 Low intake of nutrients, including potassium, vitamin A, carotene, retinol, and vitamin C, was significantly associated with COPD. Potassium 35-44 COPD Homo sapiens 125-129 27173557-3 2016 The results indicated that beta-lactoglobulin complexed with MG mainly via hydrophobic interaction with KS of 0.67x10(3)M(-)(1) at 297K. Potassium 104-106 beta-lactoglobulin Bos taurus 27-45 27798188-1 2016 The delayed rectifier potassium (K+) channel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is known to undergo oxidation in the brain, but whether this can cause neurodegeneration and cognitive impairment is not known. Potassium 22-31 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 45-50 27798188-1 2016 The delayed rectifier potassium (K+) channel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is known to undergo oxidation in the brain, but whether this can cause neurodegeneration and cognitive impairment is not known. Potassium 22-31 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 52-57 27725978-4 2016 To this end, we explored using first-principles calculations the strategy of doping of STO at the Sr site with sodium and potassium. Potassium 122-131 nuclear receptor binding SET domain protein 1 Homo sapiens 87-90 26433375-7 2016 In addition, AQP4 may influence potassium (K(+)) and calcium (Ca(2+)) ion transport, which could play decisive roles in the pathogenesis of AD. Potassium 32-41 aquaporin 4 Homo sapiens 13-17 27534754-0 2016 High potassium promotes mutual interaction between (pro)renin receptor and the local renin-angiotensin-aldosterone system in rat inner medullary collecting duct cells. Potassium 5-14 ATPase H+ transporting accessory protein 2 Rattus norvegicus 56-70 27668019-1 2016 Experiments on hippocampal slices have recorded that a novel pattern of epileptic seizures with alternating excitatory and inhibitory activities in the CA1 region can be induced by an elevated potassium ion (K(+)) concentration in the extracellular space between neurons and astrocytes (ECS-NA). Potassium 193-202 carbonic anhydrase 1 Homo sapiens 152-155 27448328-5 2016 A new AED called retigabine increases potassium efflux by changing the conformation of KCNQ 2-5 potassium channels, which leads to neuronal hyperpolarisation and a decrease in excitability. Potassium 38-47 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 87-93 27600183-0 2016 Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension. Potassium 0-9 angiotensinogen Rattus norvegicus 84-98 28002912-6 2016 N-terminal propeptide of type I procollagen (PINP) correlated with 24-h excretion of potassium, calcium and citrate. Potassium 85-94 collagen type I alpha 2 chain Homo sapiens 25-43 27558578-9 2016 In early lactation, multiple linear regressions showed that PC1 (calcium, magnesium, potassium, rubidium, and strontium intakes) was positively associated with WAZ, LAZ, and HCAZ. Potassium 85-94 polycystin 1, transient receptor potential channel interacting Homo sapiens 60-63 30193436-4 2016 In contrast to analogs of neurohypophysial nonapeptides, glucagon-like peptide-1 mimetic (exenatide) did not exert its physiological effects after oral administration, whereas it increased urinary sodium and potassium excretion following intramuscular injection. Potassium 208-217 glucagon Rattus norvegicus 57-80 29726164-6 2016 Catalase activity increased with the soil layer deepening, which was directly related to soil total potassium, and indirectly related to pH, organic matter, total nitrogen and total phosphorus through total potassium. Potassium 100-109 catalase Homo sapiens 0-8 29726164-6 2016 Catalase activity increased with the soil layer deepening, which was directly related to soil total potassium, and indirectly related to pH, organic matter, total nitrogen and total phosphorus through total potassium. Potassium 207-216 catalase Homo sapiens 0-8 27626381-4 2016 Elevation of the extracellular potassium concentration ([K+]e) impairs T cell receptor (TCR)-driven Akt-mTOR phosphorylation and effector programmes. Potassium 31-40 thymoma viral proto-oncogene 1 Mus musculus 100-103 27626381-4 2016 Elevation of the extracellular potassium concentration ([K+]e) impairs T cell receptor (TCR)-driven Akt-mTOR phosphorylation and effector programmes. Potassium 31-40 mechanistic target of rapamycin kinase Mus musculus 104-108 27626381-5 2016 Potassium-mediated suppression of Akt-mTOR signalling and T cell function is dependent upon the activity of the serine/threonine phosphatase PP2A. Potassium 0-9 thymoma viral proto-oncogene 1 Mus musculus 34-37 27626381-5 2016 Potassium-mediated suppression of Akt-mTOR signalling and T cell function is dependent upon the activity of the serine/threonine phosphatase PP2A. Potassium 0-9 mechanistic target of rapamycin kinase Mus musculus 38-42 27626381-5 2016 Potassium-mediated suppression of Akt-mTOR signalling and T cell function is dependent upon the activity of the serine/threonine phosphatase PP2A. Potassium 0-9 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 141-145 27626381-7 2016 Accordingly, augmenting potassium efflux in tumour-specific T cells by overexpressing the potassium channel Kv1.3 lowers [K+]i and improves effector functions in vitro and in vivo and enhances tumour clearance and survival in melanoma-bearing mice. Potassium 24-33 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 108-113 27568555-3 2016 Specifically, our data reveal that Kv1 channels containing Kv1.3 subunits contribute significantly to the orphan potassium current known as IsAHP in striatal cholinergic interneurons. Potassium 113-122 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 59-64 27432892-1 2016 The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target for the development of new mechanism of action diuretics. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 37-41 27422117-4 2016 Further, p53 strongly favors G-quadruplexes folded in potassium over those formed in sodium, thus indicating the telomeric G-quadruplex conformational selectivity of p53. Potassium 54-63 tumor protein p53 Homo sapiens 9-12 27626070-0 2016 Structural basis for KCNE3 modulation of potassium recycling in epithelia. Potassium 41-50 potassium voltage-gated channel subfamily E regulatory subunit 3 Homo sapiens 21-26 27422117-4 2016 Further, p53 strongly favors G-quadruplexes folded in potassium over those formed in sodium, thus indicating the telomeric G-quadruplex conformational selectivity of p53. Potassium 54-63 tumor protein p53 Homo sapiens 166-169 26856345-5 2016 Patiromer has been found to decrease serum potassium in patients with hyperkalemia having chronic kidney disease who were on renin-angiotensin-aldosterone system inhibitors. Potassium 43-52 renin Homo sapiens 125-130 27322883-8 2016 Modulation of WNK4 by [Cl]i has been shown to account for the potassium-sensing properties of the distal convoluted tubule. Potassium 62-71 WNK lysine deficient protein kinase 4 Homo sapiens 14-18 27322883-10 2016 SUMMARY: Modulation of WNK4 activity by [Cl]i can account for its dual role on the NCC, and this has important physiological implications regarding the regulation of extracellular potassium concentration. Potassium 180-189 WNK lysine deficient protein kinase 4 Homo sapiens 23-27 27068441-0 2016 SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. Potassium 38-47 serine/threonine kinase 39 Mus musculus 0-4 27011258-0 2016 Genetic variants in adiponectin and blood pressure responses to dietary sodium or potassium interventions: a family-based association study. Potassium 82-91 adiponectin, C1Q and collagen domain containing Homo sapiens 20-31 27011258-2 2016 The aim of this study was to assess the association of common genetic variants of the adiponectin gene with BP responses to controlled dietary sodium or potassium interventions. Potassium 153-162 adiponectin, C1Q and collagen domain containing Homo sapiens 86-97 27011258-10 2016 Our study indicated that the genetic polymorphisms in the adiponectin gene are significantly associated with BP responses to dietary sodium and potassium intake. Potassium 144-153 adiponectin, C1Q and collagen domain containing Homo sapiens 58-69 27068441-0 2016 SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. Potassium 38-47 odd-skipped related transcription factor 1 Mus musculus 9-13 27068441-6 2016 Potassium restriction revealed that SPAK and OSR1 play essential roles in the emerging model that NCC activation is central to sensing changes in plasma [K(+) ]. Potassium 0-9 serine/threonine kinase 39 Mus musculus 36-40 27068441-6 2016 Potassium restriction revealed that SPAK and OSR1 play essential roles in the emerging model that NCC activation is central to sensing changes in plasma [K(+) ]. Potassium 0-9 odd-skipped related transcription factor 1 Mus musculus 45-49 27068441-6 2016 Potassium restriction revealed that SPAK and OSR1 play essential roles in the emerging model that NCC activation is central to sensing changes in plasma [K(+) ]. Potassium 0-9 solute carrier family 12, member 3 Mus musculus 98-101 27068441-15 2016 SPAK-KO and kidney-specific OSR1 single knockout mice maintained plasma [K(+) ] following dietary potassium restriction, but DKO mice developed severe hypokalaemia. Potassium 98-107 odd-skipped related transcription factor 1 Mus musculus 28-32 27521112-0 2016 Gastrointestinal potassium binding-more than just lowering serum [K(+)]: patiromer, potassium balance, and the renin angiotensin aldosterone axis. Potassium 17-26 renin Homo sapiens 111-116 27206969-7 2016 Interestingly, genetic inactivation of beta3-AR in mice was associated with significantly increased urine excretion of water, sodium, potassium, and chloride. Potassium 134-143 adrenergic receptor, beta 3 Mus musculus 39-47 27276652-3 2016 In this study, we investigated the possible influence that Nogo-A may exert on other polarized molecules in Muller cells, in particular inwardly rectifying potassium channel 4.1 (Kir4.1) and aquaporin 4 (AQP4) that respectively control potassium and water exchange in glial cells. Potassium 156-165 reticulon 4 Rattus norvegicus 59-65 27421477-3 2016 We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow-derived dendritic cells, mouse neutrophils, and human PBMCs. Potassium 276-285 NLR family, pyrin domain containing 3 Mus musculus 64-69 27439875-3 2016 In mice lacking CRBN, CD4(+) T cells show increased activation and IL-2 production on T-cell receptor stimulation, ultimately resulting in increased potassium flux and calcium-mediated signaling. Potassium 149-158 cereblon Mus musculus 16-20 27439875-3 2016 In mice lacking CRBN, CD4(+) T cells show increased activation and IL-2 production on T-cell receptor stimulation, ultimately resulting in increased potassium flux and calcium-mediated signaling. Potassium 149-158 CD4 antigen Mus musculus 22-25 27439875-3 2016 In mice lacking CRBN, CD4(+) T cells show increased activation and IL-2 production on T-cell receptor stimulation, ultimately resulting in increased potassium flux and calcium-mediated signaling. Potassium 149-158 interleukin 2 Mus musculus 67-71 27439875-6 2016 Consequently, in the absence of CRBN, the expression of Kv1.3 is derepressed, resulting in increased Kv1.3 expression, potassium flux, and CD4(+) T-cell hyperactivation. Potassium 119-128 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 56-61 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 NLR family, pyrin domain containing 3 Mus musculus 17-22 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 PYD and CARD domain containing Mus musculus 23-26 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 caspase 8 Mus musculus 27-36 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 tumor necrosis factor Mus musculus 59-67 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 tumor necrosis factor receptor superfamily, member 1a Mus musculus 90-94 27156838-2 2016 In this study, we identified a novel functional role of the 5-HT1D receptor subtype in regulating A-type potassium (K(+)) currents (IA) as well as membrane excitability in small trigeminal ganglion (TG) neurons. Potassium 105-114 5-hydroxytryptamine (serotonin) receptor 1D Mus musculus 60-66 27258646-10 2016 Treatment with angiotensin II or increased extracellular potassium levels further stimulated aldosterone production in both CACNA1H(WT)- and CACNA1H(M1549V)-transfected cells. Potassium 57-66 calcium voltage-gated channel subunit alpha1 H Homo sapiens 124-131 27258646-10 2016 Treatment with angiotensin II or increased extracellular potassium levels further stimulated aldosterone production in both CACNA1H(WT)- and CACNA1H(M1549V)-transfected cells. Potassium 57-66 calcium voltage-gated channel subunit alpha1 H Homo sapiens 141-148 27151991-7 2016 Moreover, measurement of cation flux demonstrated greater loss of potassium or rubidium ions from HEK-293 cells expressing ABCB6 mutants than from cells expressing wild-type ABCB6. Potassium 66-75 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 123-128 27151991-9 2016 In conclusion, ABCB6 missense mutations in red blood cells from subjects with familial pseudohyperkalemia show elevated potassium ion efflux. Potassium 120-129 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 15-20 27140336-8 2016 This paper summarizes and expands upon a discussion at the Global Cardiovascular Clinical Trialists 2014 Forum and examines methodologic considerations for trials of new potassium binders for the prevention and management of hyperkalemia in patients with renin angiotensin aldosterone system inhibitor indications. Potassium 170-179 renin Homo sapiens 255-260 27338801-4 2016 Cecropin A induced undesired ion movement such as calcium accumulation and potassium leakage. Potassium 75-84 cecropin CBM1 Bombyx mori 0-10 26712527-8 2016 Although these mice also exhibited deficient NCC activity, NCC could be stimulated by restricting dietary potassium, which also returned BP to control levels. Potassium 106-115 solute carrier family 12, member 3 Mus musculus 59-62 27307045-3 2016 We previously showed that neuritin up-regulates transient potassium outward current (IA) subunit Kv4.2 expression and increases IA densities, in part by activating the insulin receptor signaling pathway. Potassium 58-67 neuritin 1 Mus musculus 26-34 27277658-4 2016 Stabilization of a parallel-stranded GQ RNA structure by monovalent potassium ions (K(+)) is required for high affinity binding to the LSD1-CoREST complex. Potassium 68-77 lysine demethylase 1A Homo sapiens 135-139 27307045-3 2016 We previously showed that neuritin up-regulates transient potassium outward current (IA) subunit Kv4.2 expression and increases IA densities, in part by activating the insulin receptor signaling pathway. Potassium 58-67 potassium voltage-gated channel, Shal-related family, member 2 Mus musculus 97-102 27101449-7 2016 PM2.5 from dust/soil and several crustal and transition metals, including strontium, iron, titanium, cobalt and magnesium, were significantly associated with increases in ET-1 at 1-day average; manganese and potassium were significantly associated with increases in ICAM-1 at 2-day average; and PM2.5 from industry and metal cadmium were significantly associated with decreases in VCAM-1 at 1-day average. Potassium 208-217 endothelin 1 Homo sapiens 171-175 27594164-2 2016 Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. Potassium 67-76 homeobox B1 Homo sapiens 256-267 27594164-2 2016 Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. Potassium 67-76 neuronatin Homo sapiens 269-273 27354609-2 2016 PATIENTS AND METHODS: We reviewed our prospectively collected dataset of patients with HIV with biopsy-proven KS; 17 out of 1,489 seropositive patients were identified with subsequent evidence of MSK involvement by KS. Potassium 215-217 salt inducible kinase 1 Homo sapiens 196-199 27594164-2 2016 Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. Potassium 67-76 cyclin dependent kinase inhibitor 2A Homo sapiens 279-282 27355970-2 2016 In contrast to this straightforward deprotonation of the amidine units, the reaction of 1 with the bis(trimethylsilyl)amides of sodium or potassium unexpectedly leads to a beta-metalation and an immediate deamidation reaction yielding [(thf)2 Na{Dipp-N=C(tBu)-N(H)}] (4 a) or [(thf)2 K{Dipp-N=C(tBu)-N(H)}] (4 b), respectively, as well as 2-vinylpyridine in both cases. Potassium 138-147 nudix hydrolase 3 Homo sapiens 246-250 27355970-2 2016 In contrast to this straightforward deprotonation of the amidine units, the reaction of 1 with the bis(trimethylsilyl)amides of sodium or potassium unexpectedly leads to a beta-metalation and an immediate deamidation reaction yielding [(thf)2 Na{Dipp-N=C(tBu)-N(H)}] (4 a) or [(thf)2 K{Dipp-N=C(tBu)-N(H)}] (4 b), respectively, as well as 2-vinylpyridine in both cases. Potassium 138-147 nudix hydrolase 3 Homo sapiens 286-290 27354609-7 2016 Five-year overall survival rate from initial KS diagnosis was 76%, and 60% from MSK-KS diagnosis. Potassium 84-86 salt inducible kinase 1 Homo sapiens 80-83 27354609-8 2016 The majority of patients were asymptomatic and MSK-KS involvement was demonstrated during imaging prompted by progression of their mucocutaneous KS. Potassium 51-53 salt inducible kinase 1 Homo sapiens 47-50 27354609-8 2016 The majority of patients were asymptomatic and MSK-KS involvement was demonstrated during imaging prompted by progression of their mucocutaneous KS. Potassium 145-147 salt inducible kinase 1 Homo sapiens 47-50 27191611-2 2016 They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively. Potassium 32-41 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 98-105 27191611-2 2016 They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively. Potassium 32-41 aquaporin 4 Rattus norvegicus 111-122 27191611-2 2016 They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively. Potassium 32-41 aquaporin 4 Rattus norvegicus 124-128 27354609-5 2016 At the time of MSK-KS diagnosis, more than 80% of 14 patients had excellent HIV control. Potassium 19-21 salt inducible kinase 1 Homo sapiens 15-18 27062641-10 2016 l-Lactate-induced TREK1 upregulation is a novel finding of physiological significance as TREK1 channels contribute to neuroprotection by enhancing potassium buffering and glutamate clearance capacity of astrocytes. Potassium 147-156 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 18-23 27062641-10 2016 l-Lactate-induced TREK1 upregulation is a novel finding of physiological significance as TREK1 channels contribute to neuroprotection by enhancing potassium buffering and glutamate clearance capacity of astrocytes. Potassium 147-156 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 89-94 26959386-0 2016 Trichomonas vaginalis induces IL-1beta production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux. Potassium 160-169 interleukin 1 beta Homo sapiens 30-38 26959386-0 2016 Trichomonas vaginalis induces IL-1beta production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux. Potassium 160-169 NLR family pyrin domain containing 3 Homo sapiens 109-114 26959386-12 2016 The NADPH oxidase inhibitor DPI and high extracellular potassium ion suppressed the production of IL-1beta, caspase-1, and the expression of NLRP3 and ASC proteins. Potassium 55-64 interleukin 1 beta Homo sapiens 98-106 26959386-12 2016 The NADPH oxidase inhibitor DPI and high extracellular potassium ion suppressed the production of IL-1beta, caspase-1, and the expression of NLRP3 and ASC proteins. Potassium 55-64 caspase 1 Homo sapiens 108-117 26959386-12 2016 The NADPH oxidase inhibitor DPI and high extracellular potassium ion suppressed the production of IL-1beta, caspase-1, and the expression of NLRP3 and ASC proteins. Potassium 55-64 NLR family pyrin domain containing 3 Homo sapiens 141-146 26959386-14 2016 CONCLUSIONS: T. vaginalis induces the formation of the NLRP3 inflammasome in human prostate epithelial cells via ROS and potassium ion efflux, and this results in IL-1beta production. Potassium 121-130 NLR family pyrin domain containing 3 Homo sapiens 55-60 27087421-6 2016 The results revealed that vitamin C, potassium, and calcium losses in sweat were positively correlated with systolic (SBP) and diastolic (DBP) blood pressure (all P<0.05). Potassium 37-46 selenium binding protein 1 Homo sapiens 118-121 27087421-6 2016 The results revealed that vitamin C, potassium, and calcium losses in sweat were positively correlated with systolic (SBP) and diastolic (DBP) blood pressure (all P<0.05). Potassium 37-46 D-box binding PAR bZIP transcription factor Homo sapiens 138-141 27087421-7 2016 A linear stepwise regression analysis revealed that potassium, and calcium losses in sweat adversely affected SBP and DBP (all P<0.05). Potassium 52-61 selenium binding protein 1 Homo sapiens 110-113 27087421-7 2016 A linear stepwise regression analysis revealed that potassium, and calcium losses in sweat adversely affected SBP and DBP (all P<0.05). Potassium 52-61 D-box binding PAR bZIP transcription factor Homo sapiens 118-121 27087421-8 2016 An analysis of covariance showed that SBP increased when potassium or calcium losses in sweat were >900 mg, or >100 mg, respectively. Potassium 57-66 selenium binding protein 1 Homo sapiens 38-41 27196695-1 2016 In a potassium solution, a modified 22-meric DNA sequence Pu22-T12T13 from a region proximal to the transcription initiation site of the human VEGF gene adopts a single parallel-stranded G-quadruplex conformation with a 1:4:1 loop-size arrangement. Potassium 5-14 vascular endothelial growth factor A Homo sapiens 143-147 27087421-9 2016 Further, DBP increased when potassium or calcium losses in sweat were >600 mg or >130 mg, respectively. Potassium 28-37 D-box binding PAR bZIP transcription factor Homo sapiens 9-12 26726755-4 2016 We describe their various functional (allosteric) states and how they are affected by substrates and allosteric effectors that include ATP, ADP, nonfolded protein substrates, potassium ions, and GroES (in the case of GroEL). Potassium 175-184 GroEL Escherichia coli 217-222 27389830-3 2016 The results show that the classical "transient" sodium current ([Formula: see text]) contributes mainly to the nodal action potential generation in the normal and abnormal cases for the temperature range of 20-39[Formula: see text]C, as the contribution of fast and slow potassium currents ([Formula: see text] and [Formula: see text]) to the total ionic current ([Formula: see text]) is negligible. Potassium 271-280 nodal growth differentiation factor Homo sapiens 111-116 27277795-5 2016 Coincident with the change in the intrinsic optical signal and the negative DC potential shift we recorded an increase in potassium conductance predominantly mediated by K(+) inward rectifier (Kir)2.1, which was blocked by the NMDA receptor antagonist D-AP5. Potassium 122-131 potassium inwardly-rectifying channel, subfamily J, member 2 Mus musculus 193-200 27125647-0 2016 Identification and Localization of Gold Nanoparticles in Potassium Ion Pores: Implications for Kir Blockade. Potassium 57-66 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 95-98 27020669-0 2016 Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. Potassium 0-9 interleukin 17A Homo sapiens 35-41 27020669-0 2016 Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. Potassium 0-9 mitogen-activated protein kinase 14 Homo sapiens 104-107 27020669-0 2016 Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. Potassium 0-9 mitogen-activated protein kinase 14 Homo sapiens 108-112 27020669-0 2016 Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. Potassium 0-9 serum/glucocorticoid regulated kinase 1 Homo sapiens 113-117 27020669-3 2016 Thus, we explored the effects and underlying molecular mechanism of high salt and potassium supplementation on IL-17A production in T lymphocytes. Potassium 82-91 interleukin 17A Homo sapiens 111-117 27020669-6 2016 In the participants, IL-17A levels in plasma and in peripheral blood mononuclear cells (PBMC) were significantly increased after a high-salt diet, which was dramatically reversed when potassium was supplemented. Potassium 184-193 interleukin 17A Homo sapiens 21-27 27020669-9 2016 We conclude potassium supplementation has a blocking effect on IL-17A production in T lymphocytes induced by salt loading. Potassium 12-21 interleukin 17A Homo sapiens 63-69 27105154-4 2016 Since potassium is a well-established marker for postmortem interval (PMI) and easily can be analyzed along with sodium and chloride, we have correlated sodium and chloride levels with the potassium levels and present postmortem reference ranges relative the potassium levels. Potassium 6-15 transmembrane protein 11 Homo sapiens 49-74 27189364-0 2016 Three Candida albicans potassium uptake systems differ in their ability to provide Saccharomyces cerevisiae trk1trk2 mutants with necessary potassium. Potassium 23-32 Trk1p Saccharomyces cerevisiae S288C 108-116 27189364-0 2016 Three Candida albicans potassium uptake systems differ in their ability to provide Saccharomyces cerevisiae trk1trk2 mutants with necessary potassium. Potassium 140-149 Trk1p Saccharomyces cerevisiae S288C 108-116 27086762-0 2016 Renal physiology: mTORC2 controls potassium secretion. Potassium 34-43 CREB regulated transcription coactivator 2 Mus musculus 18-24 27968757-8 2016 Corticosteroid therapy on an outpatient basis statistically significantly decreased plasma potassium levels, especially between T1 and T2 (P = .03). Potassium 91-100 interleukin 1 receptor like 1 Homo sapiens 128-137 27196604-11 2016 Moreover, DIM and TADs may be responsible for the functional plasticity of Sox9 because they are more tolerant for molecular changes (higher Ka/Ks ratio than the HMG box domain). Potassium 144-146 SRY-box transcription factor 9 Homo sapiens 75-79 26997130-1 2016 Reducing hexaazatrinaphthylene (HAN) with potassium in the presence of 18-c-6 produces [{K(18-c-6)}HAN], which contains the S=1/2 radical [HAN](.-) . Potassium 42-51 complement C6 Homo sapiens 74-77 27330882-9 2016 The analyses of the expression of cationic amino acid transporters (CAT) suggest that the CAT-2 transporter may be implicated in the potassium/cationic amino acid interchange in liver and pancreas. Potassium 133-142 dominant cataract 2 Mus musculus 90-95 27437080-1 2016 ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Potassium 32-41 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-4 27437080-1 2016 ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Potassium 66-75 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-4 27437080-2 2016 Because of this dual site of action, selective inhibitors of ROMK are expected to represent a new class of diuretics/natriuretics with superior efficacy and reduced urinary loss of potassium compared to standard-of-care loop and thiazide diuretics. Potassium 181-190 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 61-65 27089248-0 2016 The Arabidopsis nitrate transporter NPF7.3/NRT1.5 is involved in lateral root development under potassium deprivation. Potassium 96-105 nitrate transporter 1.5 Arabidopsis thaliana 36-42 27089248-0 2016 The Arabidopsis nitrate transporter NPF7.3/NRT1.5 is involved in lateral root development under potassium deprivation. Potassium 96-105 nitrate transporter 1.1 Arabidopsis thaliana 43-47 27043284-0 2016 mTORC2 critically regulates renal potassium handling. Potassium 34-43 CREB regulated transcription coactivator 2 Mus musculus 0-6 26883566-7 2016 Following treatment, the release of CGRP was stimulated using capsaicin or high extracellular potassium. Potassium 94-103 calcitonin related polypeptide alpha Homo sapiens 36-40 26883566-9 2016 In the absence of NGF, both paclitaxel and EpoB decreased capsaicin- and potassium-stimulated release and the total peptide content, suggesting that NGF may reverse MTA-induced hyposensitivity. Potassium 73-82 nerve growth factor Homo sapiens 149-152 26930642-10 2016 Moreover, ZFHX3 shRNA cells had a larger SERCA2a activity, ultra-rapid delayed rectifier potassium currents, transient outward currents and acetylcholine-sensitive potassium currents. Potassium 89-98 zinc finger homeobox 3 Homo sapiens 10-15 26930642-10 2016 Moreover, ZFHX3 shRNA cells had a larger SERCA2a activity, ultra-rapid delayed rectifier potassium currents, transient outward currents and acetylcholine-sensitive potassium currents. Potassium 164-173 zinc finger homeobox 3 Homo sapiens 10-15 26432904-9 2016 Mice lacking FKBP12 along the nephron also maintained a normal relationship between plasma potassium levels and the abundance of phosphorylated NCC with tacrolimus treatment. Potassium 91-100 FK506 binding protein 1a Mus musculus 13-19 26657714-5 2016 Following KCa activation, smooth muscle hyperpolarization is evoked by electrical coupling through myoendothelial gap junctions and/or by the potassium efflux that subsequently activates smooth muscle Kir2.1 and/or Na/K-ATPase. Potassium 142-151 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 201-207 26963838-5 2016 In this paper, we show that deletion of the fibulin-5 gene results in a significantly diminished contractility of the thoracic aorta in response to potassium loading despite otherwise preserved characteristic active behaviors, including axial force generation and rates of contraction and relaxation. Potassium 148-157 fibulin 5 Mus musculus 44-53 26574023-6 2016 Cellular IL-1beta release depended on potassium efflux and the activity of proteins nucleotide-binding oligomerization domain-like receptor protein 3 and caspase-1. Potassium 38-47 interleukin 1 beta Homo sapiens 9-17 27183948-1 2016 Neonatal Bartter syndrome (NBS) is an autosomal recessive renal tubulopathy characterized by hypokalaemic, hypochloraemic metabolic alkalosis associated with increased urinary loss of sodium, potassium, calcium and chloride. Potassium 192-201 nibrin Homo sapiens 27-30 26997130-1 2016 Reducing hexaazatrinaphthylene (HAN) with potassium in the presence of 18-c-6 produces [{K(18-c-6)}HAN], which contains the S=1/2 radical [HAN](.-) . Potassium 42-51 complement C6 Homo sapiens 94-97 26970308-0 2016 The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Potassium 112-121 spleen associated tyrosine kinase Homo sapiens 13-16 26970308-7 2016 Using a novel live cell potassium sensor we show that Syk inhibition with OXSI-2 has no effect on potassium efflux kinetics and that blockade of potassium efflux with extracellular potassium alters Syk phosphorylation. Potassium 24-33 spleen associated tyrosine kinase Homo sapiens 54-57 27058598-0 2016 Potassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness. Potassium 0-9 Trk1p Saccharomyces cerevisiae S288C 29-33 27058598-2 2016 Three types of plasma-membrane systems mediating potassium influx with different transport mechanisms have been described in yeasts: the Trk1 uniporter, the Hak cation-proton symporter and the Acu ATPase. Potassium 49-58 Trk1p Saccharomyces cerevisiae S288C 137-141 27058598-3 2016 The C. glabrata genome contains only one gene encoding putative system for potassium uptake, the Trk1 uniporter. Potassium 75-84 Trk1p Saccharomyces cerevisiae S288C 97-101 27007844-6 2016 Ptchd1 deletion attenuates TRN activity through mechanisms involving small conductance calcium-dependent potassium currents (SK). Potassium 105-114 patched domain containing 1 Mus musculus 0-6 26851241-5 2016 t-CA is a type I ligand for CYP2A6 (KS = 14.9 microM). Potassium 36-38 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 28-34 26778160-4 2016 It has been demonstrated that G-quadruplex based on PS2.M sequence under these conditions formed parallel topology, which exhibited lower activity than that observed in standard potassium-containing solution. Potassium 178-187 taste 2 receptor member 64 pseudogene Homo sapiens 52-55 26969743-0 2016 Overexpression of the rice AKT1 potassium channel affects potassium nutrition and rice drought tolerance. Potassium 32-41 K+ transporter 1 Arabidopsis thaliana 27-31 26740507-9 2016 Notably, all mutations in KCNT1 described to date are missense mutations, and electrophysiological studies have shown that they result in increased potassium current. Potassium 148-157 potassium sodium-activated channel subfamily T member 1 Homo sapiens 26-31 26966178-0 2016 Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase. Potassium 0-9 ferroxidase Saccharomyces cerevisiae S288C 91-102 30675414-7 2016 Awareness of this updated integrative control mechanism for potassium homeostasis is more relevant today when the medical community is increasingly focused on leveraging and expanding established renin-angiotensin-aldosterone system inhibitor treatment regimens and on successfully coping with the challenges of managing hyperkalemia provoked by renin-angiotensin-aldosterone system inhibitors. Potassium 60-69 renin Homo sapiens 196-201 30675414-7 2016 Awareness of this updated integrative control mechanism for potassium homeostasis is more relevant today when the medical community is increasingly focused on leveraging and expanding established renin-angiotensin-aldosterone system inhibitor treatment regimens and on successfully coping with the challenges of managing hyperkalemia provoked by renin-angiotensin-aldosterone system inhibitors. Potassium 60-69 renin Homo sapiens 346-351 26631167-5 2016 At membrane potentials more positive than equilibrium potential, intracellular polyamines plug the cytosolic surface of the Kir2.1 so that potassium ions cannot pass through the pore. Potassium 139-148 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 124-130 26944358-2 2016 The influence of intracellular angiotensin II on the regulation of potassium current and membrane potential of smooth muscle cells of mesenteric arteries and its relevance for the regulation of vascular tone was reviewed. Potassium 67-76 angiotensinogen Homo sapiens 31-45 26944358-4 2016 Emphasis was given to the opposite effects of intracellular and extracellular angiotensin II (Ang II) on the regulation of potassium current, membrane potential and contractility of vascular resistance vessels and its implication to vascular physiology and pathology and the possible role of epigenetic factors on the expression of angiotensin II (Ang II) and renin in vascular resistance vessels as well as its possible pathophysiological role in hypertension and other cardiovascular diseases. Potassium 123-132 angiotensinogen Homo sapiens 78-92 26944358-4 2016 Emphasis was given to the opposite effects of intracellular and extracellular angiotensin II (Ang II) on the regulation of potassium current, membrane potential and contractility of vascular resistance vessels and its implication to vascular physiology and pathology and the possible role of epigenetic factors on the expression of angiotensin II (Ang II) and renin in vascular resistance vessels as well as its possible pathophysiological role in hypertension and other cardiovascular diseases. Potassium 123-132 angiotensinogen Homo sapiens 94-100 26829980-0 2016 AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis. Potassium 60-69 potassium channel protein Arabidopsis thaliana 0-5 26829980-0 2016 AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis. Potassium 60-69 CBL-interacting protein kinase 23 Arabidopsis thaliana 10-16 26829980-0 2016 AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis. Potassium 60-69 K+ transporter 1 Arabidopsis thaliana 42-46 27032980-1 2016 The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. Potassium 115-124 Serotonin transporter Drosophila melanogaster 4-25 27032980-1 2016 The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. Potassium 115-124 Serotonin transporter Drosophila melanogaster 27-31 27034094-1 2016 Phosphohistidine phosphatase 1 (PHPT1), the only known phosphohistidine phosphatase in mammals, regulates phosphohistidine levels of several proteins including those involved in signaling, lipid metabolism, and potassium ion transport. Potassium 211-220 phosphohistidine phosphatase 1 Homo sapiens 0-30 27034094-1 2016 Phosphohistidine phosphatase 1 (PHPT1), the only known phosphohistidine phosphatase in mammals, regulates phosphohistidine levels of several proteins including those involved in signaling, lipid metabolism, and potassium ion transport. Potassium 211-220 phosphohistidine phosphatase 1 Homo sapiens 32-37 27065867-14 2016 These findings demonstrated that activation of alpha7nAChR could decrease on-site mortality in crush syndrome, at least in part based on the decline of serum potassium through insulin signaling-Na/K-ATPase pathway. Potassium 158-167 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-58 26923070-5 2016 Second, using high concentrations of potassium we found that HSPA1A embeds within the lipid bilayer of all phosphoinositides tested. Potassium 37-46 heat shock protein family A (Hsp70) member 1A Homo sapiens 61-67 26928907-5 2016 The transition metal Ag has larger spontaneous polarization displacements than Pb, but the Pb-O covalence seems to be weakened compared to the potassium counterpart Pb2KNb5O15 (PKN), which may account for the similar Curie temperature and uniaxial NTE behavior for PAN and PKN. Potassium 143-152 protein kinase N1 Homo sapiens 177-180 26961238-5 2016 In addition, whole patch clamp analyses of single atrial myocytes revealed that the ACh-regulated potassium current (IKA ch) was significant increased in the time course of activation and deactivation (P<0.01) in Rgs5 KO, compared to those in WT, mice. Potassium 98-107 regulator of G-protein signaling 5 Mus musculus 216-220 26732494-0 2016 Arabidopsis NRT1.5 Mediates the Suppression of Nitrate Starvation-Induced Leaf Senescence by Modulating Foliar Potassium Level. Potassium 111-120 nitrate transporter 1.1 Arabidopsis thaliana 12-16 26732494-6 2016 Moreover, when exposed to nitrate starvation, foliar potassium level decreased in nrt1.5, but adding potassium could essentially restore the early leaf senescence phenotype of nrt1.5 plants. Potassium 53-62 nitrate transporter 1.1 Arabidopsis thaliana 82-86 26732494-6 2016 Moreover, when exposed to nitrate starvation, foliar potassium level decreased in nrt1.5, but adding potassium could essentially restore the early leaf senescence phenotype of nrt1.5 plants. Potassium 101-110 nitrate transporter 1.1 Arabidopsis thaliana 176-180 26732494-7 2016 Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5. Potassium 119-128 nitrate transporter 1.1 Arabidopsis thaliana 153-157 26732494-8 2016 These data suggest that NRT1.5 likely perceives nitrate starvation-derived signals to prevent leaf senescence by facilitating foliar potassium accumulation. Potassium 133-142 nitrate transporter 1.1 Arabidopsis thaliana 24-28 26843409-2 2016 The impact of sodium, potassium, choline, guanidinium, and 1-ethyl-3-methylimidazolium chloride on the fibrillation kinetics of insulin in an acid-denaturing solvent environment is studied by fluorescence spectroscopy using thioflavin T as a fibril-specific stain. Potassium 22-31 insulin Homo sapiens 128-135 26937967-8 2016 In comparison with the classical model, the action potential shapes for power-law behaving potassium conductance (n gate) showed a longer peak and shallow hyperpolarization; for power-law activation of the sodium conductance (m gate), the action potentials had a sharp rise time; and for power-law inactivation of the sodium conductance (h gate) the spikes had wider peak that for low values of eta replicated pituitary- and cardiac-type action potentials. Potassium 91-100 endothelin receptor type A Homo sapiens 395-398 26661062-2 2016 We aimed to elucidate the poorly characterised mechanisms underlying the inhibitory effect of galanin and the potential involvement of G-protein coupled inwardly rectifying potassium, Kir 3, (GIRK) channels in glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretion. Potassium 173-182 glucagon Mus musculus 210-233 26758563-0 2016 Effect of the SGLT2 Inhibitor Dapagliflozin on Potassium Levels in Patients with Type 2 Diabetes Mellitus: A Pooled Analysis. Potassium 47-56 solute carrier family 5 member 2 Homo sapiens 14-19 26758563-3 2016 We assessed the effects of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on serum potassium levels in a pooled analysis of clinical trials in patients with type 2 diabetes mellitus (T2DM). Potassium 104-113 solute carrier family 5 member 2 Homo sapiens 31-62 26758563-3 2016 We assessed the effects of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on serum potassium levels in a pooled analysis of clinical trials in patients with type 2 diabetes mellitus (T2DM). Potassium 104-113 solute carrier family 5 member 2 Homo sapiens 64-69 26634368-4 2016 Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes. Potassium 105-114 insulin Homo sapiens 173-180 26634368-4 2016 Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes. Potassium 131-140 insulin Homo sapiens 173-180 26850185-8 2016 RESULTS: PMX-DHP maintained hemodynamics and the acid-base balance and significantly (P < 0.05) decreased the plasma concentrations of lactate, creatinine, potassium, IL-6, and IL-10 compared with dummy-DHP. Potassium 159-168 dihydropyrimidinase Rattus norvegicus 13-16 26782144-0 2016 Chronic kidney disease: Potassium efflux in APOL1 nephropathy. Potassium 24-33 apolipoprotein L1 Homo sapiens 44-49 26986142-10 2016 Among the 3 normal skin groups, the expression level of CKLF-1 was significantly higher in the KS group than in the CS or S group. Potassium 95-97 chemokine like factor Homo sapiens 56-62 25586061-2 2016 Furthermore, GLAST and GLT-1 are sodium-dependent Glu transporters (GluTs) that rely on sodium and potassium gradients generated principally by Na(+), K(+)-ATPase to generate ion gradients that drive Glu uptake. Potassium 99-108 solute carrier family 1 member 3 Homo sapiens 13-18 25586061-2 2016 Furthermore, GLAST and GLT-1 are sodium-dependent Glu transporters (GluTs) that rely on sodium and potassium gradients generated principally by Na(+), K(+)-ATPase to generate ion gradients that drive Glu uptake. Potassium 99-108 solute carrier family 1 member 2 Homo sapiens 23-28 25592718-3 2016 We find that the expression of one AP-1 member, c-Fos, is reduced in cerebellar granule neurons (CGNs) induced to die by low potassium (LK) treatment. Potassium 125-134 FBJ osteosarcoma oncogene Mus musculus 48-53 26537360-8 2016 We also found that a group of variants (predicted deleterious and non-coding), segregating with the comorbid MAEP/AEP subgroups, belong to proteins specifically involved in glutamate transport and metabolism (namely, SLC17A6, GRM8, and GLUL), as well as in potassium conductance (KCNN3). Potassium 257-266 glutamate metabotropic receptor 8 Homo sapiens 226-230 26508536-9 2016 While NO is an important signalling component in ABA-induced stomatal closure in Arabidopsis, our findings demonstrate a more complex interaction associating potassium nutrition and nitrogen metabolism in the nia1nia2 mutant that affects stomatal function. Potassium 158-167 nitrate reductase 1 Arabidopsis thaliana 209-217 26537360-8 2016 We also found that a group of variants (predicted deleterious and non-coding), segregating with the comorbid MAEP/AEP subgroups, belong to proteins specifically involved in glutamate transport and metabolism (namely, SLC17A6, GRM8, and GLUL), as well as in potassium conductance (KCNN3). Potassium 257-266 glutamate-ammonia ligase Homo sapiens 236-240 26537360-8 2016 We also found that a group of variants (predicted deleterious and non-coding), segregating with the comorbid MAEP/AEP subgroups, belong to proteins specifically involved in glutamate transport and metabolism (namely, SLC17A6, GRM8, and GLUL), as well as in potassium conductance (KCNN3). Potassium 257-266 potassium calcium-activated channel subfamily N member 3 Homo sapiens 280-285 26814970-0 2016 NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Potassium 64-73 NIMA related kinase 7 Homo sapiens 0-4 26823502-4 2016 Based on in vitro enzymatic assays using the Chaetomium thermophilum (Ct) orthologue, we show that Nug1 exhibits a low intrinsic GTPase activity that is stimulated by potassium ions, rendering Nug1 a cation-dependent GTPase. Potassium 167-176 RNA-binding GTPase NUG1 Saccharomyces cerevisiae S288C 99-103 26823502-4 2016 Based on in vitro enzymatic assays using the Chaetomium thermophilum (Ct) orthologue, we show that Nug1 exhibits a low intrinsic GTPase activity that is stimulated by potassium ions, rendering Nug1 a cation-dependent GTPase. Potassium 167-176 RNA-binding GTPase NUG1 Saccharomyces cerevisiae S288C 193-197 26814970-8 2016 NLRP3-activating stimuli promoted the NLRP3-NEK7 interaction in a process that was dependent on potassium efflux. Potassium 96-105 NLR family pyrin domain containing 3 Homo sapiens 0-5 26814970-8 2016 NLRP3-activating stimuli promoted the NLRP3-NEK7 interaction in a process that was dependent on potassium efflux. Potassium 96-105 NLR family pyrin domain containing 3 Homo sapiens 38-43 26814970-0 2016 NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Potassium 64-73 NLR family pyrin domain containing 3 Homo sapiens 33-38 26814970-8 2016 NLRP3-activating stimuli promoted the NLRP3-NEK7 interaction in a process that was dependent on potassium efflux. Potassium 96-105 NIMA related kinase 7 Homo sapiens 44-48 26814970-4 2016 Potassium efflux is a common step that is essential for NLRP3 inflammasome activation induced by many stimuli. Potassium 0-9 NLR family pyrin domain containing 3 Homo sapiens 56-61 26814970-13 2016 These studies demonstrate that NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 inflammasome assembly and activation. Potassium 84-93 NIMA related kinase 7 Homo sapiens 31-35 26814970-13 2016 These studies demonstrate that NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 inflammasome assembly and activation. Potassium 84-93 NLR family pyrin domain containing 3 Homo sapiens 112-117 26814970-5 2016 Despite extensive investigation, the molecular mechanism leading to NLRP3 activation in response to potassium efflux remains unknown. Potassium 100-109 NLR family pyrin domain containing 3 Homo sapiens 68-73 26814970-6 2016 Here we report the identification of NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding protein that acts downstream of potassium efflux to regulate NLRP3 oligomerization and activation. Potassium 168-177 NIMA related kinase 7 Homo sapiens 37-41 26814970-6 2016 Here we report the identification of NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding protein that acts downstream of potassium efflux to regulate NLRP3 oligomerization and activation. Potassium 168-177 NLR family pyrin domain containing 3 Homo sapiens 122-127 26814970-6 2016 Here we report the identification of NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding protein that acts downstream of potassium efflux to regulate NLRP3 oligomerization and activation. Potassium 168-177 NLR family pyrin domain containing 3 Homo sapiens 197-202 26689773-10 2016 Prolongation of ventricular APD and QT interval is related to the inhibition of multiple repolarization potassium currents, especially hERG channels. Potassium 104-113 ETS transcription factor ERG Homo sapiens 135-139 26683666-10 2016 These findings suggest that generation of reactive oxygen species and potassium efflux contribute to HIV-induced pyroptosis and NLRP3 inflammasome activation in podocytes. Potassium 70-79 NLR family, pyrin domain containing 3 Mus musculus 128-133 26655748-9 2016 There was a significant positive correlation between serum PTH and salivary phosphorus (r=0.342, p=0.009), and between serum PTH and salivary potassium (r=0.306, p=0.020). Potassium 142-151 parathyroid hormone Homo sapiens 125-128 26553126-0 2016 Effects of salt intake and potassium supplementation on renalase expression in the kidneys of Dahl salt-sensitive rats. Potassium 27-36 renalase, FAD-dependent amine oxidase Rattus norvegicus 56-64 26553126-4 2016 In this study, we aim to investigate how salt intake and potassium supplementation affect the level of renalase in rats. Potassium 57-66 renalase, FAD-dependent amine oxidase Rattus norvegicus 103-111 26553126-9 2016 We also found increased mRNA level and protein level of renalase, decreased catecholamine levels in plasma, and decreased BP in SS rats treated with high salt/potassium, compared with that of the high salt SS group. Potassium 159-168 renalase, FAD-dependent amine oxidase Rattus norvegicus 56-64 26553126-10 2016 Taken together, the salt-induced increase and potassium-induced decrease in BP could be mediated through renalase. Potassium 46-55 renalase, FAD-dependent amine oxidase Rattus norvegicus 105-113 26739597-3 2016 MtK(+) ATR-channel activity was assessed polarographically from the rate of State 4 respiration and by potentiometric monitoring of potassium efflux from deenergized mitochondria. Potassium 132-141 ATR serine/threonine kinase Rattus norvegicus 7-10 26755773-2 2016 Various stimuli including C-terminal cleavage, a high concentration of extracellular potassium, and voltage have been demonstrated to activate Panx1. Potassium 85-94 pannexin 1 Homo sapiens 143-148 25430801-3 2016 Insulin therapy was delayed for 9 h to allow replenishment of potassium to safe serum levels. Potassium 62-71 insulin Homo sapiens 0-7 26684962-2 2016 In this work, eight highly active sodium and potassium phenolates as highly isoselective catalysts for the ROP of rac-lactide are reported. Potassium 45-54 AKT serine/threonine kinase 1 Homo sapiens 114-117 26699492-0 2016 APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Potassium 76-85 apolipoprotein L1 Homo sapiens 0-5 26699492-7 2016 These manifestations of cytotoxicity were preceded by G1 or G2 APOL1-induced net efflux of intracellular potassium as measured by X-ray fluorescence, resulting in the activation of stress-activated protein kinases (SAPKs), p38 MAPK, and JNK. Potassium 105-114 apolipoprotein L1 Homo sapiens 63-68 25989112-10 2016 Ks inversely correlated with fibrinogen, PF4 and C-reactive protein. Potassium 0-2 platelet factor 4 Homo sapiens 41-44 26721275-3 2016 The fact that S. cerevisiae cells can grow in the presence of a broad range of concentrations of external potassium (10 muM-2.5 M) and sodium (up to 1.5 M) indicates the existence of robust mechanisms that have evolved to maintain intracellular concentrations of these cations within appropriate limits. Potassium 106-115 Mum2p Saccharomyces cerevisiae S288C 120-125 27069917-7 2016 Potassium ions induced apoptosis through regulating Bcl-2 family members and depolarized the mitochondrial membrane, especially for HepG2 cell. Potassium 0-9 BCL2 apoptosis regulator Homo sapiens 52-57 27069917-9 2016 By facilitating expression of channel protein HERG, potassium ions may prevent it from being shunted to procancerous pathways by inducing apoptosis. Potassium 52-61 potassium voltage-gated channel subfamily H member 2 Homo sapiens 46-50 27069917-11 2016 Thus, our findings suggest that potassium ions could inhibit tumorigenesis through inducing apoptosis of hepatoma cells by upregulating potassium ions transport channel proteins HERG and VDAC1. Potassium 32-41 potassium voltage-gated channel subfamily H member 2 Homo sapiens 178-182 27069917-11 2016 Thus, our findings suggest that potassium ions could inhibit tumorigenesis through inducing apoptosis of hepatoma cells by upregulating potassium ions transport channel proteins HERG and VDAC1. Potassium 32-41 voltage dependent anion channel 1 Homo sapiens 187-192 26342809-6 2016 We first used high concentrations of potassium and established that HspA1A embeds in membranes when bound to all anionic lipids tested. Potassium 37-46 heat shock protein family A (Hsp70) member 1A Homo sapiens 68-74 26138709-9 2016 Moreover, increased potassium, sourced from the BC, induced mitigation of Na uptake by maize and consequently, reduced the impact of salt stress as evidenced by overall declines in the antioxidant activities of APX and GR. Potassium 20-29 APx1-Cytosolic Ascorbate Peroxidase Zea mays 211-214 26138709-9 2016 Moreover, increased potassium, sourced from the BC, induced mitigation of Na uptake by maize and consequently, reduced the impact of salt stress as evidenced by overall declines in the antioxidant activities of APX and GR. Potassium 20-29 glutathione reductase 1 Zea mays 219-221 26639094-6 2016 As a powerful regulator of transport mechanisms across the cell membrane, JAK2 regulates a wide variety of potassium, calcium, sodium and chloride ion channels, multiple Na+-coupled cellular carriers including EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, and BGT1 as well as Na(+)/K(+)-ATPase. Potassium 107-116 Janus kinase 2 Homo sapiens 74-78 26515654-2 2016 CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes. Potassium 94-103 solute carrier family 9 (sodium/hydrogen exchanger), member 6 Mus musculus 33-39 26515654-2 2016 CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes. Potassium 94-103 solute carrier family 9 (sodium/hydrogen exchanger), member 6 Mus musculus 127-131 27455575-2 2016 Preliminary inhibition of renin-angiotensin system (RAS) activity using ACE inhibitor enalapril (1 mg/kg, orally, 7 days) increases the sensitivity of rat kidney to drug, increasing its diuretic effect 2.33 times, natriuresis 2.49 times, and urine potassium excretion 1.80 times (p < 0.05). Potassium 248-257 renin Rattus norvegicus 26-31 27455575-4 2016 Preliminary administration of direct renin inhibitor aliskiren (4 mg/kg, orally, 7 days) is accompanied by 2.30-fold increase in the diuretic effect of propranolol, 2.56-fold increase in natriuresis, and 2.27-fold increase in urine potassium excretion (p < 0.05). Potassium 232-241 renin Rattus norvegicus 37-42 27419902-0 2016 Letter: Electron-capture dissociation and collision-induced dissociation fragmentation of the supermetallized complexes of Substance P with potassium, cesium and silver. Potassium 140-149 tachykinin precursor 1 Homo sapiens 123-134 26496924-0 2016 Aquaporin 2-labeled cells differentiate to intercalated cells in response to potassium depletion. Potassium 77-86 aquaporin 2 Mus musculus 0-11 26515056-0 2016 Immunolocalization of hyperpolarization-activated cationic HCN1 and HCN3 channels in the rat nephron: regulation of HCN3 by potassium diets. Potassium 124-133 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Rattus norvegicus 116-120 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 38-43 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 97-102 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 97-102 26553871-7 2016 We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus. Potassium 109-118 acyl-CoA synthetase long-chain family member 1 Mus musculus 14-18 26553871-7 2016 We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus. Potassium 109-118 NLR family, pyrin domain containing 3 Mus musculus 36-41 25990245-7 2016 The excess release of azurophilic granules in Hv1/VSOP-deficient neutrophils was suppressed by inhibiting NADPH oxidase activity and, in part, by valinomycin, a potassium ionophore. Potassium 161-170 hepatitis virus (MHV-2) susceptibility Mus musculus 46-49 26422504-0 2016 Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis. Potassium 81-90 WNK lysine deficient protein kinase 4 Homo sapiens 38-42 26422504-3 2016 Recent data suggest that plasma potassium affects the distal nephron directly by influencing intracellular chloride, an inhibitor of the with-no-lysine kinase (WNK)-Ste20p-related proline- and alanine-rich kinase (SPAK) pathway. Potassium 32-41 serine/threonine kinase 39 Homo sapiens 214-218 26422504-5 2016 We report that modest changes in both dietary and plasma potassium affect NCC in vivo. Potassium 57-66 solute carrier family 12 member 3 Homo sapiens 74-77 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 6-15 solute carrier family 12 member 3 Homo sapiens 27-30 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 6-15 WNK lysine deficient protein kinase 4 Homo sapiens 131-135 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 6-15 solute carrier family 12 member 3 Homo sapiens 181-184 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 168-177 solute carrier family 12 member 3 Homo sapiens 27-30 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 168-177 WNK lysine deficient protein kinase 4 Homo sapiens 131-135 26422504-10 2016 Thus, potassium effects on NCC are graded within the physiological range, which explains how unique chloride-sensing properties of WNK4 enable it to mediate effects of potassium on NCC in vivo. Potassium 168-177 solute carrier family 12 member 3 Homo sapiens 181-184 27316997-4 2016 In this way, CaV1.2 activity can be measured at different membrane voltages, corresponding to either the resting or partial inactivated state, by loading the cells with a calcium probe in extracellular low or high potassium buffer. Potassium 214-223 calcium voltage-gated channel subunit alpha1 C Homo sapiens 13-19 27212600-2 2016 Recently a new enzyme-linked immunosorbent assay (ELISA) kit of concurrently detected anti-ARS antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ and anti-KS) have become to measure in the clinical setting. Potassium 158-160 secreted LY6/PLAUR domain containing 1 Homo sapiens 91-94 28132471-2 2016 There are eight potassium channels known to contribute to the potassium permeability of the inner mitochondrial membrane: ATP-regulated channel, calcium-regulated channels of large, intermediate and small conductance, voltage-regulated Kv1.3 and Kv7.4 channels, two-pore-domain TASK-3 channel and SLO2 channel. Potassium 16-25 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 246-251 26905224-10 2016 CONCLUSION: It is safe to use low dose mineralocorticoid receptor antagonists on patients receiving hemodialysis, at the end of each session of hemodialysis, and close monitoring of serum potassium levels and possible side effects is necessary. Potassium 188-197 nuclear receptor subfamily 3 group C member 2 Homo sapiens 39-65 26470810-1 2015 In rat thalamic paraventricular nucleus of thalamus (PVT) neurons, activation of thyrotropin-releasing hormone (TRH) receptors enhances excitability via concurrent decrease in G protein-coupled inwardly-rectifying potassium (GIRK)-like and activation of transient receptor potential cation (TRPC)4/5-like cationic conductances. Potassium 214-223 thyrotropin releasing hormone Rattus norvegicus 81-110 26470810-1 2015 In rat thalamic paraventricular nucleus of thalamus (PVT) neurons, activation of thyrotropin-releasing hormone (TRH) receptors enhances excitability via concurrent decrease in G protein-coupled inwardly-rectifying potassium (GIRK)-like and activation of transient receptor potential cation (TRPC)4/5-like cationic conductances. Potassium 214-223 thyrotropin releasing hormone Rattus norvegicus 112-115 26674602-9 2015 AQP2 was also detected in autophagosomes in IMCD cells of potassium-deprived rats by immunogold electron microscopy. Potassium 58-67 aquaporin 2 Rattus norvegicus 0-4 26563378-10 2015 The annual decline rate in eGFR in the fourth quartile of urinary potassium excretion (-1.3 ml/min per 1.73 m(2)/y; 95% CI, -1.5 to -1.0) was significantly slower than those in the first quartile (-2.2; 95% CI, -2.4 to -1.8). Potassium 66-75 epidermal growth factor receptor Homo sapiens 27-31 25989112-10 2016 Ks inversely correlated with fibrinogen, PF4 and C-reactive protein. Potassium 0-2 C-reactive protein Homo sapiens 49-67 26631004-0 2015 C-Reactive protein reactions to glucose-insulin-potassium infusion and relations to infarct size in patients with acute coronary syndromes. Potassium 48-57 C-reactive protein Homo sapiens 0-18 26093176-5 2015 The emergence of 2 new potassium-binding medications for acute and chronic therapy of hyperkalemia may soon allow the continued use of medications such as renin-angiotensin-aldosterone system inhibitors even in patients who are prone to hyperkalemia. Potassium 23-32 renin Homo sapiens 155-160 26362633-5 2015 Measurements of adrenal CYP11B2 expression and plasma aldosterone levels showed that increases in endogenous (obesity) or exogenous (infusion) leptin dose-dependently raised CYP11B2 expression and aldosterone without elevating plasma angiotensin II, potassium or corticosterone. Potassium 250-259 leptin Homo sapiens 143-149 26485467-7 2015 Levels of potassium in serum were positively correlated with adrenocorticotrophic hormone (ACTH) and growth hormone (GH) levels (all P<0.05). Potassium 10-19 proopiomelanocortin Homo sapiens 91-95 26485467-7 2015 Levels of potassium in serum were positively correlated with adrenocorticotrophic hormone (ACTH) and growth hormone (GH) levels (all P<0.05). Potassium 10-19 growth hormone 1 Homo sapiens 101-115 26485467-7 2015 Levels of potassium in serum were positively correlated with adrenocorticotrophic hormone (ACTH) and growth hormone (GH) levels (all P<0.05). Potassium 10-19 growth hormone 1 Homo sapiens 117-119 26405262-12 2015 Less positive tubules and less positive cells per tubule were observed for MAGE-A4 and UCHL1 expression in the KS compared with the non-treated group (P < 0.01). Potassium 111-113 MAGE family member A4 Homo sapiens 75-82 26405262-12 2015 Less positive tubules and less positive cells per tubule were observed for MAGE-A4 and UCHL1 expression in the KS compared with the non-treated group (P < 0.01). Potassium 111-113 ubiquitin C-terminal hydrolase L1 Homo sapiens 87-92 26405262-13 2015 Higher nuclear UCHL1 Sertoli cell expression was observed in the KS group compared with the non-treated group (P < 0.05). Potassium 65-67 ubiquitin C-terminal hydrolase L1 Homo sapiens 15-20 26405262-14 2015 Higher interstitial expression of INHA (P < 0.05), SOX9 (P < 0.01) and STAR (P < 0.05) was observed in KS compared with the non-treated group. Potassium 112-114 inhibin subunit alpha Homo sapiens 34-38 26405262-14 2015 Higher interstitial expression of INHA (P < 0.05), SOX9 (P < 0.01) and STAR (P < 0.05) was observed in KS compared with the non-treated group. Potassium 112-114 SRY-box transcription factor 9 Homo sapiens 54-58 26405262-14 2015 Higher interstitial expression of INHA (P < 0.05), SOX9 (P < 0.01) and STAR (P < 0.05) was observed in KS compared with the non-treated group. Potassium 112-114 steroidogenic acute regulatory protein Homo sapiens 77-81 26467721-5 2015 Recently, congenital OX40 deficiency, as determined by genome-wide exome sequencing, was shown to be associated with aggressive childhood KS in a patient, suggesting that disrupted OX40-OX40L interactions might be implicated in disease development. Potassium 138-140 TNF receptor superfamily member 4 Homo sapiens 21-25 26467721-5 2015 Recently, congenital OX40 deficiency, as determined by genome-wide exome sequencing, was shown to be associated with aggressive childhood KS in a patient, suggesting that disrupted OX40-OX40L interactions might be implicated in disease development. Potassium 138-140 TNF superfamily member 4 Homo sapiens 186-191 26445872-0 2015 Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and Ih currents. Potassium 92-101 corticotropin releasing hormone Rattus norvegicus 0-30 26252618-13 2015 Novel somatic KCNJ5 variants likely cause adenomas by loss of potassium selectivity, similar to previously described mutations. Potassium 62-71 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 14-19 25778467-0 2015 Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial. Potassium 49-58 insulin Homo sapiens 41-48 25778467-1 2015 Modifiers of response to glucose, insulin and potassium (GIK) infusion may affect clinical outcomes in acute coronary syndromes (ACS). Potassium 46-55 acyl-CoA synthetase long chain family member 1 Homo sapiens 129-132 25778467-6 2015 Gene variants may modify glucose and potassium response to GIK infusion, contributing to cardiovascular outcomes in ACS. Potassium 37-46 acyl-CoA synthetase long chain family member 1 Homo sapiens 116-119 26405101-2 2015 In heart, Kv7.1 and the accessory subunit KCNE1 forms the slowly activating delayed-rectifier potassium current current, which is enhanced by protein kinase A (PKA)-mediated phosphorylation. Potassium 94-103 potassium voltage-gated channel subfamily E member 1 Canis lupus familiaris 42-47 26540111-7 2015 Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%. Potassium 58-60 fibrinogen beta chain Homo sapiens 35-45 26472706-3 2015 The hepatitis C virus (HCV) protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death. Potassium 95-104 potassium voltage-gated channel subfamily B member 1 Homo sapiens 119-124 26472706-4 2015 Critically, neurons expressing NS5A1b (from HCV genotype 1b), but not NS5A1a, can be protected from lethal injurious stimuli via a block of Kv2.1-mediated potassium currents. Potassium 155-164 potassium voltage-gated channel subfamily B member 1 Homo sapiens 140-145 26540111-7 2015 Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%. Potassium 58-60 coagulation factor II, thrombin Homo sapiens 101-109 26540111-7 2015 Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%. Potassium 58-60 CD40 molecule Homo sapiens 147-151 25976823-5 2015 PCG is a dietary source of potassium and calcium, with low levels of fat and sugar. Potassium 27-36 psoriasis susceptibility 1 candidate 2 (human) Mus musculus 0-3 25903789-5 2015 METHODS: Lacosamide was tested in vitro on sodium and L-type calcium currents from isolated human atrial myocytes and on hERG-mediated potassium currents from stably transfected HEK293 cells. Potassium 135-144 ETS transcription factor ERG Homo sapiens 121-125 25771952-0 2015 Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene. Potassium 25-34 gap junction protein, alpha 1 Mus musculus 104-114 26256678-4 2015 Upon up-regulating the kinin system by a high potassium diet we observed reduction of tubulointerstitial fibrosis, decreased renal expression of alpha-smooth muscle actin (alpha-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. Potassium 46-55 actin gamma 2, smooth muscle Rattus norvegicus 145-170 26256678-4 2015 Upon up-regulating the kinin system by a high potassium diet we observed reduction of tubulointerstitial fibrosis, decreased renal expression of alpha-smooth muscle actin (alpha-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. Potassium 46-55 actin gamma 2, smooth muscle Rattus norvegicus 172-181 26256678-4 2015 Upon up-regulating the kinin system by a high potassium diet we observed reduction of tubulointerstitial fibrosis, decreased renal expression of alpha-smooth muscle actin (alpha-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. Potassium 46-55 vimentin Rattus norvegicus 187-195 26256678-4 2015 Upon up-regulating the kinin system by a high potassium diet we observed reduction of tubulointerstitial fibrosis, decreased renal expression of alpha-smooth muscle actin (alpha-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. Potassium 46-55 SMAD family member 3 Rattus norvegicus 205-210 26256678-4 2015 Upon up-regulating the kinin system by a high potassium diet we observed reduction of tubulointerstitial fibrosis, decreased renal expression of alpha-smooth muscle actin (alpha-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. Potassium 46-55 SMAD family member 7 Rattus norvegicus 243-248 26415804-5 2015 METHODS: A model of potassium-induced CA was performed on TLR4-mutant mice (C3H/HeJ) and wild-type mice (C3H/HeN). Potassium 20-29 toll-like receptor 4 Mus musculus 58-62 26512962-1 2015 P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. Potassium 81-90 purinergic receptor P2X 7 Homo sapiens 0-4 26512962-1 2015 P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. Potassium 81-90 NLR family pyrin domain containing 3 Homo sapiens 137-142 26512962-4 2015 Interestingly, the mitochondrial potassium pool was mobilized in a P2X7 signaling, and ATP dose-dependent manner, suggesting a role for mitochondrial sensing of cytosolic ion perturbation. Potassium 33-42 purinergic receptor P2X 7 Homo sapiens 67-71 26512962-6 2015 Further, intracellular calcium chelation with BAPTA-AM indicated that P2X7-induced potassium depletion was independent of calcium mobilization. Potassium 83-92 purinergic receptor P2X 7 Homo sapiens 70-74 26512962-7 2015 This evidence suggests that both potassium efflux and calcium influx are necessary for mitochondrial reactive oxygen generation upstream of NLRP3 inflammasome assembly and pyroptotic cell death. Potassium 33-42 NLR family pyrin domain containing 3 Homo sapiens 140-145 26512962-8 2015 We propose a model wherein potassium efflux is necessary for calcium influx, resulting in mitochondrial reactive oxygen generation to trigger the NLRP3 inflammasome. Potassium 27-36 NLR family pyrin domain containing 3 Homo sapiens 146-151 26386156-3 2015 The expression of c-fos was transiently induced by treatment of cells with high potassium (high K(+)), which evoked depolarization, or forskolin, an adenylate cyclase activator. Potassium 80-89 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-23 26477325-1 2015 The voltage-gated Kv2.1 potassium channel encoded by KCNB1 produces the major delayed rectifier potassium current in pyramidal neurons. Potassium 24-33 potassium voltage-gated channel subfamily B member 1 Homo sapiens 53-58 26500494-8 2015 Fluorescent ATP markers and FFN102 puncta were found to co-localize in VNUT positive neurons and upon stimulation with high potassium, ATP marker fluorescence at the cell membrane was reduced. Potassium 124-133 solute carrier family 17, member 9 Mus musculus 71-75 26141787-8 2015 RESULTS: Functional studies revealed that miR-153 mimic suppresses both glucose- and potassium-induced insulin secretion (GSIS and PSIS, respectively), whereas miR-153 inhibitor enhances both GSIS and PSIS. Potassium 85-94 microRNA 153 Mus musculus 42-49 26173909-8 2015 Furthermore, we show that active caspase-11 leads to a drop of intracellular potassium levels, which is necessary to activate NLRP3. Potassium 77-86 NLR family pyrin domain containing 3 Homo sapiens 126-131 26174085-5 2015 In addition to caspase-4, efficient IL-1beta conversion upon intracellular LPS delivery relies on potassium efflux, NLRP3, ASC, and caspase-1, indicating that although caspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 inflammasome activation to drive IL-1beta maturation. Potassium 98-107 interleukin 1 beta Homo sapiens 36-44 26332156-0 2015 Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Potassium 0-9 NLR family pyrin domain containing 3 Homo sapiens 102-107 26332156-0 2015 Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Potassium 34-43 NLR family pyrin domain containing 3 Homo sapiens 102-107 26136181-4 2015 Most calretinin cells (85%) exhibited large A-type potassium currents and delayed firing action potential discharge, and received strong excitatory synaptic input, whereas the remainder exhibited hyperpolarization-activated cation currents and low threshold T-type calcium currents, and tonic- or initial bursting firing patterns, and received weak excitatory synaptic input. Potassium 51-60 calbindin 2 Mus musculus 5-15 26136181-12 2015 Typical CR-expressing neurons comprised ~85% of the population and exhibited characteristic excitatory interneuron properties including delayed firing discharge, large rapid A-type potassium currents, and central, radial or vertical cell morphologies. Potassium 181-190 calbindin 2 Mus musculus 8-10 26136181-17 2015 Under normal conditions, the contribution of "Typical" excitatory CR-expressing neurons to overall SDH excitability may be limited by the presence of A-type potassium currents, which limit the effectiveness of their strong excitatory input. Potassium 157-166 calbindin 2 Mus musculus 66-68 26105002-6 2015 Among the potassium currents responsible for AP repolarization phase, IK1 was found to be almost insensitive to niferidil. Potassium 10-19 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 70-73 26385038-0 2015 Facility variation and predictors of serum potassium monitoring after initiation of a mineralocorticoid receptor antagonist in patients with heart failure. Potassium 43-52 nuclear receptor subfamily 3 group C member 2 Homo sapiens 86-112 26022182-0 2015 ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Potassium 62-71 Eph receptor B1 Rattus norvegicus 0-3 26022182-0 2015 ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Potassium 62-71 thyrotropin releasing hormone Rattus norvegicus 30-33 26022182-0 2015 ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Potassium 62-71 RAS-like, estrogen-regulated, growth-inhibitor Rattus norvegicus 56-61 25853863-6 2015 In addition, dexamethasone treatment of enteroendocrine GLUTag cells reduced GLP-1 secretion induced by glucose, 2-deoxy-D-glucose, fructose and potassium, whereas the secretory response to a phorbol ester was unaltered. Potassium 145-154 glucagon Mus musculus 77-82 25856239-6 2015 Here we show that OECs express voltage-dependent potassium currents compatible with inward rectifier (Kir ) and delayed rectifier (KDR ) channels. Potassium 49-58 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 102-105 25856239-6 2015 Here we show that OECs express voltage-dependent potassium currents compatible with inward rectifier (Kir ) and delayed rectifier (KDR ) channels. Potassium 49-58 kinase insert domain receptor Homo sapiens 131-134 26179130-0 2015 Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons. Potassium 88-97 potassium voltage-gated channel subfamily D member 2 Homo sapiens 55-60 25784710-7 2015 Overall, the use of mineralocorticoid receptor antagonists was associated with an increased serum potassium (0.23, 95% CI 0.13, 0.33 mmol/l; p<0.0001) and higher risk ratio (1.76, 95% CI 1.20, 2.57; p=0.001) of hyperkalemia. Potassium 98-107 nuclear receptor subfamily 3 group C member 2 Homo sapiens 20-46 25827095-8 2015 Potassium-induced depolarization rapidly de-clustered dynamin 3 from nerve terminals within minutes. Potassium 0-9 dynamin 3 Homo sapiens 54-63 26312501-2 2015 This hyperactivity is caused, at least in part, by decreased Kv7.2/3 (KCNQ2/3) potassium currents. Potassium 79-88 potassium voltage-gated channel, subfamily Q, member 2 Mus musculus 70-75 26304939-3 2015 The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as a mitochondrial channel pore-forming subunit. Potassium 33-42 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 89-96 26272420-1 2015 Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved in atopy. Potassium 18-27 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 45-51 26264372-12 2015 Analysis of selection pressure on protein-coding genes using Ka/Ks ratio showed significant positive selection exerted on the rps7 gene of the pineapple chloroplast with P less than 0.05. Potassium 64-66 rps7 Ananas comosus 126-130 26023797-3 2015 Marked reduction of uncoupling protein 2 (UCP2) expression upon high salt-low potassium diet associates with increased renal injury in SHRSP. Potassium 78-87 uncoupling protein 2 Rattus norvegicus 20-40 26023797-3 2015 Marked reduction of uncoupling protein 2 (UCP2) expression upon high salt-low potassium diet associates with increased renal injury in SHRSP. Potassium 78-87 uncoupling protein 2 Rattus norvegicus 42-46 25640031-14 2015 Moreover, long-term diuretic use was associated with SCC risk, driven by potassium-sparing agents alone or in combination with low-ceiling diuretics. Potassium 73-82 serpin family B member 3 Homo sapiens 53-56 26307551-2 2015 The KCNQ1/KCNE1 complex in cardiomyocytes exhibited slow activated potassium (I(ks)) currents. Potassium 80-82 potassium voltage-gated channel subfamily KQT member 1 Cavia porcellus 4-9 26307551-2 2015 The KCNQ1/KCNE1 complex in cardiomyocytes exhibited slow activated potassium (I(ks)) currents. Potassium 80-82 potassium voltage-gated channel subfamily E member 1 Cavia porcellus 10-15 26039623-6 2015 Potassium supplementation resulted in reduction of SBP by 4.7 mmHg [95% confidence interval (CI) 2.4-7.0] and DBP by 3.5 mmHg (95% CI 1.3-5.7) in all patients. Potassium 0-9 selenium binding protein 1 Homo sapiens 51-54 26013542-3 2015 We observed that Cmpd101 inhibits the desensitization of the G protein-activated inwardly-rectifying potassium current evoked by receptor-saturating concentrations of methionine-enkephalin (Met-Enk), [d-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), endomorphin-2, and morphine in rat and mouse locus coeruleus (LC) neurons. Potassium 101-110 proenkephalin Rattus norvegicus 178-188 26013542-3 2015 We observed that Cmpd101 inhibits the desensitization of the G protein-activated inwardly-rectifying potassium current evoked by receptor-saturating concentrations of methionine-enkephalin (Met-Enk), [d-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), endomorphin-2, and morphine in rat and mouse locus coeruleus (LC) neurons. Potassium 101-110 proenkephalin Rattus norvegicus 194-197 26013542-3 2015 We observed that Cmpd101 inhibits the desensitization of the G protein-activated inwardly-rectifying potassium current evoked by receptor-saturating concentrations of methionine-enkephalin (Met-Enk), [d-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), endomorphin-2, and morphine in rat and mouse locus coeruleus (LC) neurons. Potassium 101-110 proenkephalin Rattus norvegicus 234-244 25814167-4 2015 KS-IMM cells expressed increased levels of inflammatory cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LO) pathway enzymes when compared with human microvascular dermal endothelial cells (HMVEC-d). Potassium 0-2 prostaglandin-endoperoxide synthase 2 Homo sapiens 56-72 25814167-4 2015 KS-IMM cells expressed increased levels of inflammatory cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LO) pathway enzymes when compared with human microvascular dermal endothelial cells (HMVEC-d). Potassium 0-2 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-79 25814167-4 2015 KS-IMM cells expressed increased levels of inflammatory cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LO) pathway enzymes when compared with human microvascular dermal endothelial cells (HMVEC-d). Potassium 0-2 arachidonate 5-lipoxygenase Homo sapiens 85-99 25814167-11 2015 Treatment of KS-IMM cells with LXA4 resulted in selective localization of VEGFR-2 in nonlipid raft (non-LR) and ALXR to LR fractions. Potassium 13-15 kinase insert domain receptor Homo sapiens 74-81 25814167-11 2015 Treatment of KS-IMM cells with LXA4 resulted in selective localization of VEGFR-2 in nonlipid raft (non-LR) and ALXR to LR fractions. Potassium 13-15 formyl peptide receptor 2 Homo sapiens 112-116 26048399-10 2015 Multiple linear regression adjusted for age, gender, body mass index and fibrinogen showed that TG (beta=-0.41), vWF (beta=-0.29) and PF4 (beta=-0.28) are the independent predictors of Ks (R(2)=0.78), while CLT was independently predicted by TG (beta=0.37), PAI-1 antigen (beta=0.29) and vWF (beta=0.26) in the AF group (R(2)=0.39). Potassium 185-187 platelet factor 4 Homo sapiens 134-137 26048399-10 2015 Multiple linear regression adjusted for age, gender, body mass index and fibrinogen showed that TG (beta=-0.41), vWF (beta=-0.29) and PF4 (beta=-0.28) are the independent predictors of Ks (R(2)=0.78), while CLT was independently predicted by TG (beta=0.37), PAI-1 antigen (beta=0.29) and vWF (beta=0.26) in the AF group (R(2)=0.39). Potassium 185-187 serpin family E member 1 Homo sapiens 258-263 26048399-10 2015 Multiple linear regression adjusted for age, gender, body mass index and fibrinogen showed that TG (beta=-0.41), vWF (beta=-0.29) and PF4 (beta=-0.28) are the independent predictors of Ks (R(2)=0.78), while CLT was independently predicted by TG (beta=0.37), PAI-1 antigen (beta=0.29) and vWF (beta=0.26) in the AF group (R(2)=0.39). Potassium 185-187 von Willebrand factor Homo sapiens 288-291 26501103-9 2015 We therefore conducted whole cell patch clamp measurements of M-type potassium currents, which showed a ~ 90% decrease in Ts65Dn neurons, while HCN measurements displayed an increase of ~ 65% in Ts65Dn cells. Potassium 69-78 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 122-128 26380428-8 2015 Labs were notable for potassium"s running on the low side of normal and low levels of both renin (less than 0.6 with normal less than or equal to 0.6-3.0) and aldosterone (1.0 with normal 3-16 ng/dL). Potassium 22-31 renin Homo sapiens 91-96 26013830-1 2015 CLC-K/barttin chloride channels are essential for NaCl re-absorption in Henle"s loop and for potassium secretion by the stria vascularis in the inner ear. Potassium 93-102 barttin CLCNK type accessory subunit beta Homo sapiens 6-13 25872187-0 2015 VEGF attenuated increase of outward delayed-rectifier potassium currents in hippocampal neurons induced by focal ischemia via PI3-K pathway. Potassium 54-63 vascular endothelial growth factor A Rattus norvegicus 0-4 25872187-2 2015 The present study investigated whether VEGF could attenuate ischemia-induced increase of the potassium currents in the hippocampal pyramidal neurons of rats after ischemic injury. Potassium 93-102 vascular endothelial growth factor A Rattus norvegicus 39-43 26217182-0 2015 Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Potassium 96-105 solute carrier family 12 member 6 Homo sapiens 52-56 26057242-4 2015 Our goal is to determine if the inward rectifying potassium current (IK1) causes the inhibition of hyperpolarization. Potassium 50-59 IKAROS family zinc finger 1 Homo sapiens 69-72 25863256-0 2015 Urocortin2 prolongs action potential duration and modulates potassium currents in guinea pig myocytes and HEK293 cells. Potassium 60-69 LOW QUALITY PROTEIN: urocortin-2 Cavia porcellus 0-10 25863256-2 2015 This study goal was to further test the hypothesis that urocortin2 may modulate action potentials as well as rapidly and slowly activating delayed rectifier potassium currents. Potassium 157-166 LOW QUALITY PROTEIN: urocortin-2 Cavia porcellus 56-66 25863256-8 2015 And urocortin2 caused reduction of rapidly activating delayed rectifier potassium currents in hERG-HEK293 cells. Potassium 72-81 LOW QUALITY PROTEIN: urocortin-2 Cavia porcellus 4-14 25863256-9 2015 In addition, urocortin2 slowed the rate of slowly activating delayed rectifier potassium channel activation, and rightward shifted the threshold of slowly activating delayed rectifier potassium currents to more positive potentials. Potassium 79-88 LOW QUALITY PROTEIN: urocortin-2 Cavia porcellus 13-23 26103554-7 2015 These observations indicate that the WT and the Val302del mutant subunits co-assemble in the cell membrane and that the mutation affects potassium conductivity and (or) gating of the WT/Val302del heteromeric Kir2.1 channels. Potassium 137-146 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 208-214 26036654-11 2015 For a rapid drop in potassium by shifting the potassium to the intracellular space, administration of glucose with insulin and high-dose inhalative administration of betamimetics can be used. Potassium 20-29 insulin Homo sapiens 115-122 25127675-3 2015 We report here that Kir1.1 channels are required for gastric acid secretion and that this channel participates with Kv7.1 (KCNQ1/KvLQT1) in the potassium recycling process. Potassium 144-153 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 20-26 25127675-3 2015 We report here that Kir1.1 channels are required for gastric acid secretion and that this channel participates with Kv7.1 (KCNQ1/KvLQT1) in the potassium recycling process. Potassium 144-153 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 123-128 25127675-3 2015 We report here that Kir1.1 channels are required for gastric acid secretion and that this channel participates with Kv7.1 (KCNQ1/KvLQT1) in the potassium recycling process. Potassium 144-153 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 129-135 25127675-6 2015 Luminal application of potassium-restored acid secretion in perfused gastric glands from Kir1.1-deficient as well as barium-blocked wild-type mice. Potassium 23-32 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 89-95 26104484-1 2015 TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Potassium 186-195 toll like receptor 2 Homo sapiens 0-4 26104484-1 2015 TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Potassium 186-195 NLR family pyrin domain containing 3 Homo sapiens 14-19 26104484-1 2015 TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Potassium 186-195 MYD88 innate immune signal transduction adaptor Homo sapiens 57-62 26104484-1 2015 TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Potassium 186-195 interleukin 1 receptor associated kinase 1 Homo sapiens 63-68 25970152-6 2015 Exhaustive reduction of the tris-[8]annulenyl isocyanurate with potassium in THF generates the first-ever observed hexa-anion of an isocyanurate. Potassium 64-73 hexosaminidase subunit alpha Homo sapiens 115-119 25912880-10 2015 However, amphetamine (30 microm)-induced potassium currents produced by efflux of DA were enhanced in BACE1(-/-) mice, perhaps indicating increased vesicular DA content in the midbrain. Potassium 41-50 beta-site APP cleaving enzyme 1 Mus musculus 102-107 25984914-1 2015 In an atmosphere of potassium ions, a modified c-MYC NHE III1 sequence with two G-to-T mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded G-quadruplex. Potassium 20-29 MYC proto-oncogene, bHLH transcription factor Homo sapiens 47-52 25966806-0 2015 A relationship between serum potassium concentration and insulin resistance in patients with type 2 diabetes mellitus. Potassium 29-38 insulin Homo sapiens 57-64 25966806-2 2015 However, the relationship between serum potassium concentration and insulin resistance is poorly defined. Potassium 40-49 insulin Homo sapiens 68-75 25966806-3 2015 This study aimed to investigate the association between serum potassium concentration and insulin resistance in these patients. Potassium 62-71 insulin Homo sapiens 90-97 25966806-6 2015 The association between serum potassium concentration and insulin resistance was analyzed using linear regression methods. Potassium 30-39 insulin Homo sapiens 58-65 25966806-10 2015 When the patients were compared based on insulin resistance, serum potassium concentration was higher in the patients with insulin resistance compared with the patients without (4.25 +- 0.48 vs. 4.09 +- 0.44 mEq/l, p = 0.015). Potassium 67-76 insulin Homo sapiens 41-48 25966806-10 2015 When the patients were compared based on insulin resistance, serum potassium concentration was higher in the patients with insulin resistance compared with the patients without (4.25 +- 0.48 vs. 4.09 +- 0.44 mEq/l, p = 0.015). Potassium 67-76 insulin Homo sapiens 123-130 25966806-14 2015 CONCLUSIONS: Serum potassium concentration is likely to be increased in the patients with poorly controlled type 2 DM with insulin resistance than in those without insulin resistance. Potassium 19-28 insulin Homo sapiens 123-130 25966806-14 2015 CONCLUSIONS: Serum potassium concentration is likely to be increased in the patients with poorly controlled type 2 DM with insulin resistance than in those without insulin resistance. Potassium 19-28 insulin Homo sapiens 164-171 25938784-6 2015 Inward rectifying, ATP-sensitive potassium (K(ATP)) channels mediated the response to elevated glucose levels, as pharmacological manipulation of K(ATP) channels in the hippocampus altered both ISF Abeta levels and neuronal activity. Potassium 33-42 amyloid beta (A4) precursor protein Mus musculus 198-203 25777080-0 2015 A physiological, biochemical and proteomic characterization of Saccharomyces cerevisiae trk1,2 transport mutants grown under limiting potassium conditions. Potassium 134-143 Trk1p Saccharomyces cerevisiae S288C 88-92 25777080-4 2015 Using a combination of physiological, biochemical and proteomic approaches, we show that during growth at suboptimal potassium concentrations, double trk1,2 mutants accumulate less potassium and reach lower yields. Potassium 117-126 Trk1p Saccharomyces cerevisiae S288C 150-154 25777080-4 2015 Using a combination of physiological, biochemical and proteomic approaches, we show that during growth at suboptimal potassium concentrations, double trk1,2 mutants accumulate less potassium and reach lower yields. Potassium 181-190 Trk1p Saccharomyces cerevisiae S288C 150-154 25847511-3 2015 In the present study, we investigated the expression pattern and role of SOX7 in potassium deprivation-induced rat cerebellar granule neuron apoptosis. Potassium 81-90 SRY-box transcription factor 7 Rattus norvegicus 73-77 26175853-3 2015 K(+) channel interaction protein 2 (KChIP2) is a necessary subunit for the formation of transient outward potassium current (Ito.f) which plays a critical role in early repolarization and QTc interval of heart. Potassium 106-115 Kv channel-interacting protein 2 Mus musculus 0-34 26175853-3 2015 K(+) channel interaction protein 2 (KChIP2) is a necessary subunit for the formation of transient outward potassium current (Ito.f) which plays a critical role in early repolarization and QTc interval of heart. Potassium 106-115 Kv channel-interacting protein 2 Mus musculus 36-42 25953924-8 2015 The shortened QTc interval from Cirp ablation was tightly linked to an abbreviated action potential duration in cardiac myocytes, which was attributable to increased transient outward potassium current (Ito). Potassium 184-193 cold inducible RNA binding protein Rattus norvegicus 32-36 26467143-1 2015 Voltage-gated potassium channels, Kv1.3, which were discovered in 1984, are integral membrane proteins which are activated ("open") upon change of the cell membrane potential, enabling a passive flux of potassium ions across the cell membrane. Potassium 14-23 potassium voltage-gated channel subfamily A member 3 Homo sapiens 34-39 25500109-15 2015 CONCLUSIONS: Important lifestyle- and diet-related factors associated with copeptin concentration are current smoking, alcohol use, protein and potassium intake, and particularly fluid and sodium intake. Potassium 144-153 arginine vasopressin Homo sapiens 75-83 25847511-4 2015 Our results showed that both mRNA and protein levels of SOX7 were upregulated when potassium was deprived. Potassium 83-92 SRY-box transcription factor 7 Rattus norvegicus 56-60 25847511-6 2015 Moreover, we found that beta-catenin activity was suppressed during apoptosis and that beta-catenin inhibition was crucial for potassium deprivation-induced neuronal apoptosis. Potassium 127-136 catenin beta 1 Rattus norvegicus 87-99 25402014-7 2015 In line with this, we show that A2A R promotes synchronous pyramidal cell firing in hyperexcitable conditions where extracellular potassium is elevated or following high-frequency electrical stimulation. Potassium 130-139 adenosine A2a receptor Homo sapiens 32-37 25825440-7 2015 Additionally, potassium efflux and lysosomal acidification induced by the fungus were important steps in the caspase-1 activation mechanism. Potassium 14-23 caspase 1 Mus musculus 109-118 25393609-6 2015 Potassium-induced depolarization demonstrates release of tau and tau fragments from pre-synaptic terminals, with increased release from AD compared to control samples. Potassium 0-9 microtubule associated protein tau Homo sapiens 57-60 25393609-6 2015 Potassium-induced depolarization demonstrates release of tau and tau fragments from pre-synaptic terminals, with increased release from AD compared to control samples. Potassium 0-9 microtubule associated protein tau Homo sapiens 65-68 25714986-1 2015 The repair ligation-mediated light-producing DNA machine can produce light through transforming the repetitive DNA cleavage/ligation motions into optical energy without the requirement of either external reporting reagents or excitation light, and it can be applied for sensitive and selective detection of DNA, thrombin, adenosine, potassium ions (K(+)) and endonuclease even in human serum. Potassium 333-342 coagulation factor II, thrombin Homo sapiens 312-320 25687974-1 2015 Potassium ion (K+) uptake in yeast is mediated mainly by the Trk1/2 proteins that enable cells to survive on external K+ concentration as low as a few muM. Potassium 0-9 Trk1p Saccharomyces cerevisiae S288C 61-67 25539776-1 2015 We studied the potassium current flowing through TREK-1 channels in rat cardiac ventricular myocytes. Potassium 15-24 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 49-55 25600998-12 2015 Taken together, these results indicate that root uptake of arsenate is probably not via sulfate transporters, but the poor growth of the double mutant of sultr1;1 and sultr1;2 was due to its poor sulfate status and decreased levels of thiols, which had pleiotropic effects on the root uptake and translocation of potassium and phosphorus and arsenic tolerance. Potassium 313-322 sulfate transporter 1;1 Arabidopsis thaliana 154-175 25867027-5 2015 The resting state was changed to a period-1 firing pattern via on-off firing pattern as the potassium concentration, static pressure, or depolarization current was changed. Potassium 92-101 period circadian regulator 1 Rattus norvegicus 35-43 25805816-1 2015 With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. Potassium 60-69 WNK lysine deficient protein kinase 4 Homo sapiens 0-23 25805816-1 2015 With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. Potassium 60-69 WNK lysine deficient protein kinase 4 Homo sapiens 25-29 25805816-1 2015 With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. Potassium 60-69 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 78-83 25805816-1 2015 With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. Potassium 60-69 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 85-89 25681192-6 2015 Amylosin may thus trigger the activation of the NLRP3 inflammasome and subsequently cytokine release by causing potassium efflux from exposed cells. Potassium 112-121 NLR family pyrin domain containing 3 Homo sapiens 48-53 25904892-2 2015 Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs, which decreases the driving force for the transduction current. Potassium 153-162 potassium voltage-gated channel subfamily Q member 4 Homo sapiens 147-152 25614660-4 2015 Acute salt stress caused the strongest membrane potential depolarization, highest sodium and proton influx, and potassium loss from npr1-5 roots in comparison with the wild type and nudt7 mutant. Potassium 112-121 regulatory protein (NPR1) Arabidopsis thaliana 132-136 25614660-6 2015 Long-term salt exposure resulted in the highest sodium and the lowest potassium concentration in the shoots of npr1-5 mutant in comparison with the wild type and nudt7 mutant. Potassium 70-79 regulatory protein (NPR1) Arabidopsis thaliana 111-117 25614660-7 2015 The above results demonstrate that NPR1-dependent SA signalling is pivotal to (i) controlling Na(+) entry into the root tissue and its subsequent long-distance transport into the shoot, and (ii) preventing a potassium loss through depolarization-activated outward-rectifying potassium and ROS-activated non-selective cation channels. Potassium 208-217 regulatory protein (NPR1) Arabidopsis thaliana 35-39 25614660-7 2015 The above results demonstrate that NPR1-dependent SA signalling is pivotal to (i) controlling Na(+) entry into the root tissue and its subsequent long-distance transport into the shoot, and (ii) preventing a potassium loss through depolarization-activated outward-rectifying potassium and ROS-activated non-selective cation channels. Potassium 275-284 regulatory protein (NPR1) Arabidopsis thaliana 35-39 25683504-9 2015 Careful potassium level monitoring in concomitant users of spironolactone and ACE/ARB is necessary. Potassium 8-17 angiotensin I converting enzyme Homo sapiens 78-81 25477470-3 2015 The relative abundance and role of FL- vs. KS-SPAK in regulating Na(+)-K(+)-2Cl(-) cotransporter (NKCC2) in thick ascending limb (TAL) are not completely understood. Potassium 43-45 solute carrier family 12, member 1 Mus musculus 98-103 26336742-3 2015 5-100 LM of H2S donor--sodium hydrosulfide (NaHS) increased mechanical tension of SMC precontracted with high potassium solution that was abolished by bumetanide--the inhibitor of Na+, K+, 2Cl(-) -cotransporter (NKCC), but 100-1000 microM of NaHS relaxed SMS. Potassium 110-119 solute carrier family 12 member 1 Homo sapiens 180-210 26081057-0 2015 [Effects of activity of 11beta-hydroxysteroid dehydrogenase type 2 on serum potassium levels in Cushing"s syndrome patients]. Potassium 76-85 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 24-66 25793825-2 2015 We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica. Potassium 185-194 MHC class I polypeptide-related sequence A Homo sapiens 64-68 25793825-2 2015 We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica. Potassium 185-194 MHC class I polypeptide-related sequence A Homo sapiens 203-207 25322916-7 2015 Our results demonstrated that out of the 21 biomarkers screened at mRNA and protein levels, alpha2beta1-integrin, Hsp27, PAI-2, MMP-19 and CGRP showed significantly higher expression (p < 0.05) in KS compared to NS and HS. Potassium 200-202 calcitonin related polypeptide alpha Homo sapiens 139-143 25301495-6 2015 Furthermore, the cell patch-clamp test demonstrated that the overexpression of GDNF and NT-3 in BMSCs enhanced voltage-activated potassium currents, implying that BMSCs possess great potential as a cell-based therapeutic candidate to treat neurological diseases. Potassium 129-138 glial cell derived neurotrophic factor Rattus norvegicus 79-83 25301495-6 2015 Furthermore, the cell patch-clamp test demonstrated that the overexpression of GDNF and NT-3 in BMSCs enhanced voltage-activated potassium currents, implying that BMSCs possess great potential as a cell-based therapeutic candidate to treat neurological diseases. Potassium 129-138 neurotrophin 3 Rattus norvegicus 88-92 25514102-11 2015 AR CAG repeat length was comparable in KS and controls, and among KS CAG correlated to arm length (P = .04), arm span (P = .01), and leg length (P = .04). Potassium 39-41 androgen receptor Homo sapiens 0-2 25712016-0 2015 Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions. Potassium 41-50 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 35-40 25545278-13 2015 Overall, our work emphasizes that measured intrinsic properties (inward rectification and external [K] dependence) and localization of Kir channels in the TTS membranes are ideally suited for re-capturing potassium ions from the TTS lumen during, and immediately after, repetitive stimulation under physiological conditions. Potassium 205-214 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 135-138 24899236-3 2015 Mutations of Kir channels cause human hereditary diseases collectively called Kir channelopathies, many of which are characterized by disorders of sodium and potassium homeostasis. Potassium 158-167 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 13-16 24899236-3 2015 Mutations of Kir channels cause human hereditary diseases collectively called Kir channelopathies, many of which are characterized by disorders of sodium and potassium homeostasis. Potassium 158-167 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 78-81 24899236-4 2015 Studies on these genetic Kir channelopathies have shed light on novel pathophysiological mechanisms, including renal sodium and potassium handling, potassium shifting in skeletal muscles, and aldosterone production in the adrenal glands. Potassium 128-137 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 25-28 24899236-4 2015 Studies on these genetic Kir channelopathies have shed light on novel pathophysiological mechanisms, including renal sodium and potassium handling, potassium shifting in skeletal muscles, and aldosterone production in the adrenal glands. Potassium 148-157 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 25-28 24899236-5 2015 Here, we review several recent advances in Kir channels and their clinical implications in sodium and potassium homeostasis. Potassium 102-111 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 43-46 25645492-6 2015 Ghrelin elicited TTX-insensitive changes in dF/F indicative of rises in calcium, and a portion of these rises were independent of membrane depolarization, as they persisted in conditions of high extracellular potassium solutions and were found to involve SERCA-pump mediated intracellular calcium stores. Potassium 209-218 ghrelin Mus musculus 0-7 25483891-0 2015 Mdm31 protein mediates sensitivity to potassium ionophores but does not regulate mitochondrial morphology or phospholipid trafficking in Schizosaccharomyces pombe. Potassium 38-47 Mdm31p Saccharomyces cerevisiae S288C 0-5 25477470-6 2015 The ratios of FL-SPAK to KS-SPAK in mTAL, cTAL, and DCT were 12.3, 12.5, and 10.2, respectively. Potassium 25-27 serine/threonine kinase 39 Mus musculus 28-32 25844191-3 2015 Each (18-crown-6)potassium cation is in contact with the eta(3)-coordinating ligand of one cobaltate complex. Potassium 17-26 endothelin receptor type A Homo sapiens 57-60 25716831-2 2015 We report here that BACE1 regulates neuronal excitability through an unorthodox, nonenzymatic interaction with members of the KCNQ (Kv7) family that give rise to the M-current, a noninactivating potassium current with slow kinetics. Potassium 195-204 beta-site APP cleaving enzyme 1 Mus musculus 20-25 25709906-7 2015 Furthermore, in the SV40-immortalized human corneal epithelial cells, NLRP3 was exclusively located in the nucleus, and treatment of the cells with high concentration of extracellular potassium (known as an inhibitor of NLRP3 activation) effectively drove NLRP3 back to the cytoplasm as reflected by both immunohistochemistry and Western blot. Potassium 184-193 NLR family pyrin domain containing 3 Homo sapiens 70-75 25709906-7 2015 Furthermore, in the SV40-immortalized human corneal epithelial cells, NLRP3 was exclusively located in the nucleus, and treatment of the cells with high concentration of extracellular potassium (known as an inhibitor of NLRP3 activation) effectively drove NLRP3 back to the cytoplasm as reflected by both immunohistochemistry and Western blot. Potassium 184-193 NLR family pyrin domain containing 3 Homo sapiens 220-225 25709906-7 2015 Furthermore, in the SV40-immortalized human corneal epithelial cells, NLRP3 was exclusively located in the nucleus, and treatment of the cells with high concentration of extracellular potassium (known as an inhibitor of NLRP3 activation) effectively drove NLRP3 back to the cytoplasm as reflected by both immunohistochemistry and Western blot. Potassium 184-193 NLR family pyrin domain containing 3 Homo sapiens 220-225 25313717-3 2015 Flavonol-induced HSA (tryptophan) fluorescence quenching data yield the dynamic quenching constant (KD) as 5.42 x 10(3) M(-1) and the association constant (Ks) as 5.59 x 10(4) M(-1). Potassium 156-158 albumin Homo sapiens 17-20 25652939-9 2015 The Ka/Ks analysis showed that atp8 gene in the Crossoptilon likely experienced a strong selective pressure in adaptation to the plateau environment. Potassium 7-9 ATP8 Crossoptilon auritum 31-35 25685180-17 2015 CONCLUSIONS: In both cohorts, ADCs have decreased over time, though incidence of KS was higher at INI than VCCC. Potassium 81-83 PHD finger protein 5A Homo sapiens 98-101 25391539-8 2015 RESULTS: In the SOS reference study, subjects homozygous for the d3-GHR weighed ~4 kg more (P=0.011), and had larger waist-to-hip ratio (WHR, P=0.036), larger waist circumference (P=0.016), and more fat-free mass estimated from total body potassium (P=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). Potassium 239-248 growth hormone receptor Homo sapiens 68-71 24895271-2 2015 METHODS: Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk. Potassium 167-176 insulin Homo sapiens 193-200 24895271-4 2015 In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Potassium 51-60 insulin Homo sapiens 93-100 25243715-0 2015 Different spatial expressions of c-Fos in the nucleus of the solitary tract following taste stimulation with sodium, potassium, and ammonium ions in rats. Potassium 117-126 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-38 25505069-5 2015 Nrf2 knockdown in LTC decreased expression of antioxidant genes and genes involved in KS pathogenesis such as the NAD(P)H quinone oxidase 1 (NQO1), gamma glutamylcysteine synthase heavy unit (gammaGCSH), the cysteine transporter (xCT), interleukin 6 (IL-6), and vascular endothelial growth factor A (VEGF-A) genes. Potassium 86-88 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25505069-16 2015 This study suggests that KSHV hijacks the host"s autophagic protein SQSTM1 to induce Nrf2 activation, thereby manipulating the infected host gene regulation to promote KS pathogenesis. Potassium 25-27 sequestosome 1 Homo sapiens 68-74 25505069-16 2015 This study suggests that KSHV hijacks the host"s autophagic protein SQSTM1 to induce Nrf2 activation, thereby manipulating the infected host gene regulation to promote KS pathogenesis. Potassium 25-27 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 25425491-3 2015 We show here that depletion of potassium from the medium or alteration of diverse regulatory pathways controlling potassium uptake, such as the Trk potassium transporters or the Pma1 H(+) -ATPase, triggers a response that mimics that of phosphate (Pi) deprivation, exemplified by accumulation of the high-affinity Pi transporter Pho84. Potassium 31-40 phosphate transporter PHO84 Saccharomyces cerevisiae S288C 329-334 25425491-3 2015 We show here that depletion of potassium from the medium or alteration of diverse regulatory pathways controlling potassium uptake, such as the Trk potassium transporters or the Pma1 H(+) -ATPase, triggers a response that mimics that of phosphate (Pi) deprivation, exemplified by accumulation of the high-affinity Pi transporter Pho84. Potassium 114-123 phosphate transporter PHO84 Saccharomyces cerevisiae S288C 329-334 25135348-4 2015 Significant associations were also found for ABCB11 and SLC30A8 single-nucleotide polymorphisms (SNPs) and glucose responses, and an SEC61A2 SNP with a potassium response to GIK. Potassium 152-161 SEC61 translocon subunit alpha 2 Homo sapiens 133-140 25344677-1 2015 Potassium inwardly rectifying channel, subfamily J, member 1 (KCNJ1), as an ATP-dependent potassium channel, plays an essential role in potassium balance. Potassium 90-99 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-60 25344677-1 2015 Potassium inwardly rectifying channel, subfamily J, member 1 (KCNJ1), as an ATP-dependent potassium channel, plays an essential role in potassium balance. Potassium 90-99 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 62-67 25195496-0 2015 Understanding the effects of gamma-irradiation on potassium levels in red cell concentrates stored in SAG-M for neonatal red cell transfusion. Potassium 50-59 S-antigen visual arrestin Homo sapiens 102-105 25195496-3 2015 MATERIALS AND METHODS: The effects of irradiation on potassium release in RCCs stored in SAG-M were investigated under three scenarios. Potassium 53-62 S-antigen visual arrestin Homo sapiens 89-92 25564733-8 2015 Altogether, our results suggest that amelioration of potassium leaks through potassium homeostasis mechanisms may minimize muscle damage of myopathies due to certain RyR1 mutations. Potassium 53-62 ryanodine receptor 1, skeletal muscle Mus musculus 166-170 25564733-8 2015 Altogether, our results suggest that amelioration of potassium leaks through potassium homeostasis mechanisms may minimize muscle damage of myopathies due to certain RyR1 mutations. Potassium 77-86 ryanodine receptor 1, skeletal muscle Mus musculus 166-170 25552692-6 2015 Hence, this review summarizes what is known about the effect of PI3K and its downstream effectors, including Akt, on sodium, potassium, and calcium currents in cardiac myocytes. Potassium 125-134 AKT serine/threonine kinase 1 Homo sapiens 109-112 25833523-0 2015 Thiotaurine protects mouse cerebellar granule neurons from potassium deprivation-induced apoptosis by inhibiting the activation of caspase-3. Potassium 59-68 caspase 3 Mus musculus 131-140 25339702-1 2015 Despite similar stimulatory actions on the epithelial sodium channel (ENaC)-mediated sodium reabsorption in the distal tubule, insulin promotes kaliuresis, whereas insulin-like growth factor-1 (IGF-1) causes a reduction in urinary potassium levels. Potassium 231-240 insulin-like growth factor 1 Mus musculus 164-192 25339702-1 2015 Despite similar stimulatory actions on the epithelial sodium channel (ENaC)-mediated sodium reabsorption in the distal tubule, insulin promotes kaliuresis, whereas insulin-like growth factor-1 (IGF-1) causes a reduction in urinary potassium levels. Potassium 231-240 insulin-like growth factor 1 Mus musculus 194-199 25339702-10 2015 We propose that IGF-1, by stimulating ClC-K2 channels, promotes net Na(+) and Cl(-) reabsorption, thus reducing driving force for potassium secretion by the CCD. Potassium 130-139 insulin-like growth factor 1 Mus musculus 16-21 25339702-10 2015 We propose that IGF-1, by stimulating ClC-K2 channels, promotes net Na(+) and Cl(-) reabsorption, thus reducing driving force for potassium secretion by the CCD. Potassium 130-139 chloride channel, voltage-sensitive Kb Mus musculus 38-44 25597679-4 2015 The MLK model was employed to simulate the adsorption kinetics of Cu(II), Co(II), Cd(II), Zn(II) and Ni(II) on MnO2 at pH3.2 or 3.3 to get the values of KS-kinetic. Potassium 153-155 mitogen-activated protein kinase kinase kinase 13 Homo sapiens 4-7 25444851-7 2015 CONCLUSION: S3 mutations in KCNQ1 cause diverse kinetic defects in I(Ks), affecting opening and closing properties, and can account for LQT1 phenotypes. Potassium 69-71 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 28-33 26491696-8 2015 In addition, SGK1 and Akt cooperatively regulate potassium secretion by renal outer medullary potassium channel (ROMK). Potassium 49-58 serum/glucocorticoid regulated kinase 1 Homo sapiens 13-17 26491696-8 2015 In addition, SGK1 and Akt cooperatively regulate potassium secretion by renal outer medullary potassium channel (ROMK). Potassium 49-58 AKT serine/threonine kinase 1 Homo sapiens 22-25 26491696-8 2015 In addition, SGK1 and Akt cooperatively regulate potassium secretion by renal outer medullary potassium channel (ROMK). Potassium 49-58 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 113-117 24894912-9 2015 Moreover, beta1-AAs (0.001, 0.01, 0.1 mumol/L) dose-dependently increased the rapidly activating delayed rectifier potassium current (I Kr), but similarly decreased the slowly activating delayed rectifier potassium current (I Ks) and increased L-type calcium currents at the different concentrations. Potassium 226-228 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 10-15 25824645-0 2015 Effect of salt intake and potassium supplementation on urinary renalase and serum dopamine levels in Chinese adults. Potassium 26-35 renalase, FAD dependent amine oxidase Homo sapiens 63-71 25824645-1 2015 OBJECTIVE: The aim of our study was to assess the effects of altered salt and potassium intake on urinary renalase and serum dopamine levels in humans. Potassium 78-87 renalase, FAD dependent amine oxidase Homo sapiens 106-114 25824645-5 2015 During high-potassium intake, urinary renalase excretions were not significantly different from the high-salt diet, whereas they were significantly higher than the low-salt levels. Potassium 12-21 renalase, FAD dependent amine oxidase Homo sapiens 38-46 25824645-9 2015 CONCLUSIONS: The present study indicates that dietary salt intake and potassium supplementation increase urinary renalase and serum dopamine levels in Chinese subjects. Potassium 70-79 renalase, FAD dependent amine oxidase Homo sapiens 113-121 25288122-5 2015 The system is capable of quantification of potassium ions down to 0.31 muM. Potassium 43-52 latexin Homo sapiens 71-74 26004420-7 2015 EXPERT OPINION: Although anti-hypertensive drugs armamentarium enumerates a plethora of therapeutic classes, including diuretics, the novel class of ROMK inhibitors may find a place in this crowded market, because of the diuretic/natriuretic effects, devoid of worrying influence on potassium balance. Potassium 283-292 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 149-153 25092804-0 2015 Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance. Potassium 124-133 ciliary neurotrophic factor Homo sapiens 0-27 25092804-0 2015 Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance. Potassium 124-133 ciliary neurotrophic factor Homo sapiens 29-33 25447080-0 2015 Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Potassium 80-89 discs large MAGUK scaffold protein 1 Mus musculus 56-61 25841124-6 2015 In this study, we hypothesize that disrupted fission and fusion balance by increased Drp-1 and decreased Mfn2 expression in cardiomyocytes affects their contractility through alterations in the calcium and potassium concentrations. Potassium 206-215 mitofusin 2 Mus musculus 105-109 25374106-4 2015 However, in vivo electrochemical measures of potassium-evoked glutamate release in the CA1, but not the CA3 or dentate, was significantly elevated in AbetaPP/PS1 mice. Potassium 45-54 carbonic anhydrase 1 Mus musculus 87-90 25374106-4 2015 However, in vivo electrochemical measures of potassium-evoked glutamate release in the CA1, but not the CA3 or dentate, was significantly elevated in AbetaPP/PS1 mice. Potassium 45-54 histocompatibility 2, class II antigen A, beta 1 Mus musculus 150-157 25374106-4 2015 However, in vivo electrochemical measures of potassium-evoked glutamate release in the CA1, but not the CA3 or dentate, was significantly elevated in AbetaPP/PS1 mice. Potassium 45-54 presenilin 1 Mus musculus 158-161 27057553-0 2015 Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux. Potassium 93-102 S100 calcium binding protein A8 Homo sapiens 13-19 25704028-0 2015 Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation. Potassium 75-84 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Homo sapiens 0-40 25704028-0 2015 Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation. Potassium 75-84 potassium voltage-gated channel subfamily H member 2 Homo sapiens 70-74 25704028-1 2015 The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as alpha1-adrenergic and M1-muscarinic receptors (alpha1R and M1R, respectively), at least partly via the reduction of membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Potassium 44-53 potassium voltage-gated channel subfamily H member 2 Homo sapiens 38-42 26277930-0 2015 Common Variants in Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions: A family-Based Association Study. Potassium 116-125 serum/glucocorticoid regulated kinase 1 Homo sapiens 19-58 26277930-0 2015 Common Variants in Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions: A family-Based Association Study. Potassium 116-125 serum/glucocorticoid regulated kinase 1 Homo sapiens 60-64 26277930-2 2015 This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium interventions. Potassium 137-146 serum/glucocorticoid regulated kinase 1 Homo sapiens 77-81 26277930-7 2015 However, the associations between selected SNPs in the SGK1 gene and BP responses to high-sodium or high-sodium plus potassium-supplementation intervention did not reach statistical significance. Potassium 117-126 serum/glucocorticoid regulated kinase 1 Homo sapiens 55-59 25827151-4 2015 The pathophysiological mechanism comprises an increase in insulin levels, resulting in shifts of phosphate, potassium and magnesium into the intracellular environment, as well as fluid retention and relative deficiency of vitamin B1. Potassium 108-117 insulin Homo sapiens 58-65 25616098-1 2015 AIM: Polymorphisms in the mineralocorticoid receptor may affect urinary sodium and potassium excretion. Potassium 83-92 nuclear receptor subfamily 3 group C member 2 Homo sapiens 26-52 25378686-0 2015 The major facilitator superfamily transporter ZIFL2 modulates cesium and potassium homeostasis in Arabidopsis. Potassium 73-82 zinc induced facilitator-like 2 Arabidopsis thaliana 46-51 26198561-2 2015 It has become more common in cardiovascular practice due to the growing population of patients with chronic kidney disease and the broad application of drugs that modulate renal elimination of potassium by reducing production of angiotensin II (angiotensin-converting enzyme inhibitors, direct renin inhibitors, beta-adrenergic receptor antagonists), blocking angiotensin II receptors (angiotensin receptor blockers), or antagonizing the action of aldosterone on mineralocorticoid receptors (mineralocorticoid receptor antagonists). Potassium 193-202 angiotensinogen Homo sapiens 229-243 25807794-8 2015 CONCLUSION: LIG concentration-dependently protects against low potassium-induced apoptosis in CGN at least partly through GABAa receptor activation and its downstream IGF-1 signaling pathway. Potassium 63-72 insulin-like growth factor 1 Rattus norvegicus 167-172 25355526-5 2014 In addition, 4 can subsequently be reduced with potassium to furnish again a Mg(I) compound, namely [K(thf)3]2[Mg2(L(1))2] (3). Potassium 48-57 immunoglobulin kappa variable 1-16 Homo sapiens 115-119 25331946-6 2014 We found that JAZ protects cerebellar granule neurons against potassium deprivation-induced death and cortical neurons from death resulting from oxidative stress. Potassium 62-71 zinc finger protein 346 Homo sapiens 14-17 25408964-5 2014 We find that the interaction of hUNG with undamaged DNA is electrostatically driven at a physiological concentration of potassium ions (DeltaGelect = -3.5 +- 0.5 kcal mol(-1)), with only a small nonelectrostatic contribution (DeltaGnon = -2.0 +- 0.2 kcal mol(-1)). Potassium 120-129 uracil DNA glycosylase Homo sapiens 32-36 25480344-3 2014 Aim of the present post-hoc analysis of the PARAT trial was the description of serum potassium levels with certoparin compared to placebo. Potassium 85-94 parathymosin Homo sapiens 44-49 25404286-6 2014 LT-induced NLRP1b inflammasome activation was shown to be impaired upon inhibition of potassium efflux, which is known to play a major role in NLRP3 inflammasome formation and ASC dimerization. Potassium 86-95 NLR family, pyrin domain containing 1B Mus musculus 11-17 25404286-6 2014 LT-induced NLRP1b inflammasome activation was shown to be impaired upon inhibition of potassium efflux, which is known to play a major role in NLRP3 inflammasome formation and ASC dimerization. Potassium 86-95 NLR family, pyrin domain containing 3 Mus musculus 143-148 25404286-6 2014 LT-induced NLRP1b inflammasome activation was shown to be impaired upon inhibition of potassium efflux, which is known to play a major role in NLRP3 inflammasome formation and ASC dimerization. Potassium 86-95 PYD and CARD domain containing Mus musculus 176-179 25445147-5 2014 Importantly, we provided evidence to suggest that macrophage cell membrane binding to immobilized crystals was sufficient to induce IL-1beta release, and this activation of the NLRP3 inflammasome was inhibited by blocking potassium efflux. Potassium 222-231 interleukin 1 beta Homo sapiens 132-140 25445147-5 2014 Importantly, we provided evidence to suggest that macrophage cell membrane binding to immobilized crystals was sufficient to induce IL-1beta release, and this activation of the NLRP3 inflammasome was inhibited by blocking potassium efflux. Potassium 222-231 NLR family pyrin domain containing 3 Homo sapiens 177-182 25273356-6 2014 SCH 66712 displays type I binding to CYP3A4 with a spectral binding constant (Ks) of 42.9 +- 2.9 microM. Potassium 78-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 37-43 23386284-6 2014 RESULTS: Irbesartan (1-50 muM) attenuated the Hypo-S-induced increase in I(Ks) and shortening of APD90. Potassium 75-77 latexin Homo sapiens 26-29 23386284-2 2014 Blockade of angiotensin II subtype 1 receptors (AT(1)R) attenuates this increase in I(Ks). Potassium 86-88 angiotensin II receptor type 1 Homo sapiens 12-54 23386284-7 2014 Hypo-S increased the I(Ks) by 113.4%, whereas Hypo-S + 1 muM irbesartan and Hypo-S + 50 muM irbesartan increased the I(Ks) by only 74.5% and 70.3%, respectively. Potassium 119-121 latexin Homo sapiens 88-91 25464889-6 2014 GALP (10(-10 )M and 10(-9 )M) induced intensified basal AVP release from the NH and Hth-NH complex as well as the release of potassium-evoked AVP from the Hth-NH. Potassium 125-134 galanin-like peptide Rattus norvegicus 0-4 25464889-6 2014 GALP (10(-10 )M and 10(-9 )M) induced intensified basal AVP release from the NH and Hth-NH complex as well as the release of potassium-evoked AVP from the Hth-NH. Potassium 125-134 arginine vasopressin Rattus norvegicus 142-145 24486303-4 2014 The importance of this interaction is clearly decreased during subsequent stages, during which endothelin-1 may participate in the genesis of ventricular tachycardia or fibrillation via other mechanisms; of these, the effects of endothelin-1 on repolarizing potassium currents and electrical conduction via gap junctions merit further research. Potassium 258-267 endothelin 1 Homo sapiens 95-107 24486303-4 2014 The importance of this interaction is clearly decreased during subsequent stages, during which endothelin-1 may participate in the genesis of ventricular tachycardia or fibrillation via other mechanisms; of these, the effects of endothelin-1 on repolarizing potassium currents and electrical conduction via gap junctions merit further research. Potassium 258-267 endothelin 1 Homo sapiens 229-241 25398734-3 2014 The role that modified sodium or potassium intake plays in influencing the renin-angiotensin system, arterial stiffness, and endothelial dysfunction remains of interest in current research. Potassium 33-42 renin Homo sapiens 75-80 25228688-1 2014 KChIP3 (potassium channel interacting protein 3) is a calcium-binding protein that binds at the N terminus of the Kv4 voltage-gated potassium channel through interactions at two contact sites and has been shown to regulate potassium current gating kinetics as well as channel trafficking in cardiac and neuronal cells. Potassium 8-17 potassium voltage-gated channel interacting protein 3 Homo sapiens 0-6 25393291-4 2014 METHODS AND RESULTS: We show the impact of YxkO on the activity of SigB-dependent Pctc promoter and adaptation to osmotic and ethanol stress and potassium limitation respectively. Potassium 145-154 NAD(P)H dehydratase Bacillus subtilis subsp. subtilis str. 168 43-47 25355908-0 2014 Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis. Potassium 48-57 K+ transporter 1 Arabidopsis thaliana 34-38 26021685-7 2014 RESULTS: After administration of 10 gram glucose and 10 units regular insulin bolus intravenously, a drastic and significant decreased of serum potassium from 5.73 +- 0.44 to 4.48 +- 0.06 mEq/L was noted. Potassium 144-153 insulin Homo sapiens 70-77 26021685-9 2014 CONCLUSIONS: An intravenous bolus of 10 units regular insulin with 10 gram glucose was able to decrease the serum -potassium level effectively and additionally increase serum glucose in LDLT patients. Potassium 115-124 insulin Homo sapiens 54-61 25220289-7 2014 Ka/Ks ratios indicated that Gadd45g1 and Gadd45g2 may have undergone a high number of mutations and have a divergence time of only about 68,000years, although Gadd45g homologs are highly conserved. Potassium 3-5 uncharacterized protein LOC103396969 Cynoglossus semilaevis 28-36 25220289-7 2014 Ka/Ks ratios indicated that Gadd45g1 and Gadd45g2 may have undergone a high number of mutations and have a divergence time of only about 68,000years, although Gadd45g homologs are highly conserved. Potassium 3-5 growth arrest and DNA-damage-inducible, gamma a Cynoglossus semilaevis 41-49 25169970-0 2014 Toll-like receptor 4 activation promotes cardiac arrhythmias by decreasing the transient outward potassium current (Ito) through an IRF3-dependent and MyD88-independent pathway. Potassium 97-106 toll-like receptor 4 Rattus norvegicus 0-20 25280426-1 2014 Refeeding syndrome (RFS) broadly encompasses a severe electrolyte disturbance (principally low serum concentrations of intracellular ions such as phosphate, magnesium, and potassium) and metabolic abnormalities in undernourished patients undergoing refeeding whether orally, enterally, or parenterally. Potassium 172-181 FRTS1 Homo sapiens 20-23 24463703-0 2014 Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation. Potassium 95-104 interleukin 6 signal transducer Mus musculus 24-29 24463703-4 2014 In this study, we show that nociceptor-specific deletion of gp130 alters excitability parameters that are linked to changes in the potassium conductance. Potassium 131-140 interleukin 6 signal transducer Mus musculus 60-65 24463703-7 2014 The main difference between gp130-deficient and control neurons was a significant increase in the conductance of both delayed rectifier as well as A-type potassium currents. Potassium 154-163 interleukin 6 signal transducer Mus musculus 28-33 25171201-1 2014 The neuropeptide nociceptin/orphanin FQ (N/OFQ) has been shown to inhibit delayed rectifier potassium current (IK) in acutely dissociated rat parietal cortical neurons. Potassium 92-101 prepronociceptin Rattus norvegicus 17-27 25171201-1 2014 The neuropeptide nociceptin/orphanin FQ (N/OFQ) has been shown to inhibit delayed rectifier potassium current (IK) in acutely dissociated rat parietal cortical neurons. Potassium 92-101 prepronociceptin Rattus norvegicus 28-39 25138250-2 2014 CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosion in aqueous environment containing potassium ion at the physiological level. Potassium 11-20 carboxypeptidase E Rattus norvegicus 0-3 25138250-2 2014 CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosion in aqueous environment containing potassium ion at the physiological level. Potassium 136-145 carboxypeptidase E Rattus norvegicus 0-3 25169970-0 2014 Toll-like receptor 4 activation promotes cardiac arrhythmias by decreasing the transient outward potassium current (Ito) through an IRF3-dependent and MyD88-independent pathway. Potassium 97-106 interferon regulatory factor 3 Rattus norvegicus 132-136 25169970-0 2014 Toll-like receptor 4 activation promotes cardiac arrhythmias by decreasing the transient outward potassium current (Ito) through an IRF3-dependent and MyD88-independent pathway. Potassium 97-106 MYD88, innate immune signal transduction adaptor Rattus norvegicus 151-156 24840118-6 2014 Because TRPM4 is a Ca(2+) -activated monovalent-selective cation channel, these findings imply that TRPM4 contributes to potassium ion transport, essential for the signal transduction in IHCs and the formation of endolymph by marginal cells. Potassium 121-130 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 8-13 25164821-1 2014 The Ste20-related kinase SPAK regulates sodium, potassium, and chloride transport in a variety of tissues. Potassium 48-57 serine/threonine kinase 39 Homo sapiens 25-29 25318749-0 2014 Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration. Potassium 24-33 ETS transcription factor ERG Homo sapiens 19-23 25318749-2 2014 Ionic current carried by hERG channels (IhERG) is known to exhibit a paradoxical dependence on external potassium concentration ([K(+)]e), but effects of acute [K(+)]e changes on the response of IhERG to premature stimulation have not been characterized. Potassium 104-113 ETS transcription factor ERG Homo sapiens 25-29 25080489-0 2014 Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase. Potassium 83-92 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-14 25080489-0 2014 Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase. Potassium 83-92 angiotensin II receptor, type 1a Mus musculus 130-133 25080489-3 2014 By means of intracellular microelectrode recordings we found that ANG II reduced gCl in the nanomolar range and in a concentration-dependent manner (EC50 = 0.06 muM) meanwhile increasing potassium conductance (gK). Potassium 187-196 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 66-72 25044933-3 2014 The role of MLC1 and HEPACAM is unknown, although they have been related with the processes of cell-volume regulation and potassium siphoning by astrocytes. Potassium 122-131 modulator of VRAC current 1 Homo sapiens 12-16 24840118-6 2014 Because TRPM4 is a Ca(2+) -activated monovalent-selective cation channel, these findings imply that TRPM4 contributes to potassium ion transport, essential for the signal transduction in IHCs and the formation of endolymph by marginal cells. Potassium 121-130 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 100-105 24895213-0 2014 Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Potassium 9-18 betaine--homocysteine S-methyltransferase Homo sapiens 71-111 24895213-3 2014 Herein we report that BHMT is activated by potassium ions with an apparent K(M) for K+ of about 100 microM. Potassium 43-52 betaine--homocysteine S-methyltransferase Homo sapiens 22-26 24895213-8 2014 The potassium binding residues in BHMT partially overlap with the previously identified DGG (Asp26-Gly27-Gly28) fingerprint in the Pfam 02574 group of methyltransferases. Potassium 4-13 betaine--homocysteine S-methyltransferase Homo sapiens 34-38 24895213-10 2014 Together, the data herein indicate that the role of potassium ions in BHMT is structural and that potassium ion facilitates the specific binding of homocysteine to the active site of the enzyme. Potassium 52-61 betaine--homocysteine S-methyltransferase Homo sapiens 70-74 25269074-10 2014 Application of PDF inhibited outward potassium or inward sodium currents, sometimes in the same neuron. Potassium 37-46 peptide deformylase, mitochondrial Homo sapiens 15-18 25086309-3 2014 Regarding sodium- and potassium-coupled Cl(-) transport (NKCC1) both up- and downregulations have been proposed. Potassium 22-31 solute carrier family 12 member 2 Homo sapiens 57-62 25197769-2 2014 We synthesized a cation-substituted MOF, K2(H2adp)[Zn2(ox)3] 3H2O, where the ammonium ions in a well-defined hydrogen-bonding network are substituted with non-hydrogen-bonding potassium ions, without any apparent change in the crystal structure. Potassium 176-185 lysine acetyltransferase 8 Homo sapiens 36-39 25086033-0 2014 Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. Potassium 24-33 Wnk kinase Drosophila melanogaster 51-54 25086033-0 2014 Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. Potassium 24-33 serine/threonine kinase 39 Homo sapiens 55-59 25086033-0 2014 Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. Potassium 24-33 frayed Drosophila melanogaster 60-64 25352996-4 2014 Here, we report the rational design of structure-switching DNA aptamers, based on the thrombin binding aptamer (TBA), that bind potassium with affinities that bridge the gap between previously reported weak-binding and strong-binding aptamers. Potassium 128-137 coagulation factor II, thrombin Homo sapiens 86-94 25037568-9 2014 In the KCNE1 distal C-terminus, the LQT mutation P127T suppressed yotiao-dependent cAMP-mediated upregulation of the I(KS) current, which was caused by reduced KCNQ1 phosphorylation at S27. Potassium 119-121 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 7-12 25037568-9 2014 In the KCNE1 distal C-terminus, the LQT mutation P127T suppressed yotiao-dependent cAMP-mediated upregulation of the I(KS) current, which was caused by reduced KCNQ1 phosphorylation at S27. Potassium 119-121 A-kinase anchoring protein 9 Homo sapiens 66-72 25037568-9 2014 In the KCNE1 distal C-terminus, the LQT mutation P127T suppressed yotiao-dependent cAMP-mediated upregulation of the I(KS) current, which was caused by reduced KCNQ1 phosphorylation at S27. Potassium 119-121 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 160-165 24666922-10 2014 Serum potassium levels decreased similarly after insulin injection during both hypoglycaemia and euglycaemia. Potassium 6-15 insulin Homo sapiens 49-56 24955869-9 2014 On the other hand, we found a significant decrease of XIAP levels in cultured CGN maintained in chronic potassium deprivation, an apoptotic condition, suggesting a possible relationship between XIAP levels and neuronal viability. Potassium 104-113 X-linked inhibitor of apoptosis Rattus norvegicus 54-58 24955869-9 2014 On the other hand, we found a significant decrease of XIAP levels in cultured CGN maintained in chronic potassium deprivation, an apoptotic condition, suggesting a possible relationship between XIAP levels and neuronal viability. Potassium 104-113 X-linked inhibitor of apoptosis Rattus norvegicus 194-198 24955869-11 2014 The down-regulation of XIAP in CGN cultured under survival conditions (chronic potassium depolarization) induced a reduction of cell viability and an increment of apoptotic cells. Potassium 79-88 X-linked inhibitor of apoptosis Rattus norvegicus 23-27 24927994-2 2014 Outward potassium currents mediated by two-pore-domain potassium (K2P) channels promote repolarization of excitable cells. Potassium 8-17 keratin 76 Homo sapiens 66-69 25730969-2 2014 Inhibitory analysis of ATP-dependent potassium transport in mitochondria with polyclonal antibodies to calreticulin was carried out. Potassium 37-46 calreticulin Homo sapiens 103-115 24845199-3 2014 In the present study we analyze the effects of KB-R7943 on the ATP-dependent potassium current (IKATP) recorded by whole-cell patch-clamp in ventricular cardiomyocytes from a mammal (mouse) and a fish (crucian carp). Potassium 77-86 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 96-101 25047526-8 2014 The reduction in renal potassium excretion due to inhibition of the renin-angiotensin-aldosterone system represents the most important mechanism by which drugs are known to cause hyperkalemia. Potassium 23-32 renin Homo sapiens 68-73 25047526-10 2014 Drugs that impair renal potassium excretion are mainly represented by angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, direct renin inhibitors, nonsteroidal anti-inflammatory drugs, calcineurin inhibitors, heparin and derivatives, aldosterone antagonists, potassium-sparing diuretics, trimethoprim, and pentamidine. Potassium 24-33 renin Homo sapiens 153-158 25089715-3 2014 The aim of this study was to evaluate the effect and specific underlying mechanism of BS, NaCl, and the mineral mixture (components of BS other than NaCl, including zinc, magnesium, and potassium, Mix) on IL-32 signaling using the human monocyte cell line, THP-1. Potassium 186-195 interleukin 32 Homo sapiens 205-210 24875671-11 2014 There was a significant reduction in E-selectin following the high (Median = 5.96 ng/ml) vs the low potassium diet (Median = 6.24 ng/ml), z = -2.49, P = 0.013. Potassium 100-109 selectin E Homo sapiens 37-47 24297522-6 2014 Another THIK-2 mutant, in which the putative retention/retrieval signal RRR at positions 14-16 was replaced by AAA, produced a similar potassium current. Potassium 135-144 potassium two pore domain channel subfamily K member 12 Homo sapiens 8-14 25092935-8 2014 Our most notable findings included the following: (1) monitoring of serum potassium concentrations identified unanticipated hypokalemia episodes, not recognized before standard work implementation, and earlier addition of potassium to fluids resulted in a notable reduction in hypokalemia; (2) improvements in insulin infusion management were associated with reduced duration of ICU stay; and (3) with overall improved DKA management and education, cerebral edema occurrence and bicarbonate use were reduced. Potassium 74-83 insulin Homo sapiens 310-317 25092935-8 2014 Our most notable findings included the following: (1) monitoring of serum potassium concentrations identified unanticipated hypokalemia episodes, not recognized before standard work implementation, and earlier addition of potassium to fluids resulted in a notable reduction in hypokalemia; (2) improvements in insulin infusion management were associated with reduced duration of ICU stay; and (3) with overall improved DKA management and education, cerebral edema occurrence and bicarbonate use were reduced. Potassium 222-231 insulin Homo sapiens 310-317 24947509-2 2014 Assembled with the beta-subunit KCNE1, Kv7.1 conducts the slowly activating potassium current IKs, which is one of the major currents underlying repolarization of the cardiac action potential. Potassium 76-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 32-37 25057880-0 2014 A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium. Potassium 142-151 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 8-13 25196520-0 2014 Functional cross-talk between the alpha1- and beta1-adrenergic receptors modulates the rapidly activating delayed rectifier potassium current in guinea pig ventricular myocytes. Potassium 124-133 beta-1 adrenergic receptor Cavia porcellus 34-72 25126967-6 2014 Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current. Potassium 161-170 nerve growth factor Rattus norvegicus 36-39 25126967-6 2014 Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current. Potassium 161-170 Rap guanine nucleotide exchange factor 4 Rattus norvegicus 43-48 25126967-6 2014 Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current. Potassium 161-170 Rap guanine nucleotide exchange factor 4 Rattus norvegicus 79-84 25126967-6 2014 Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current. Potassium 161-170 calcitonin-related polypeptide alpha Rattus norvegicus 178-182 24798513-7 2014 Hcrt/Orx neurons are excited through block of a potassium conductance and release glutamate with their peptides in TMN. Potassium 48-57 hypocretin neuropeptide precursor Homo sapiens 0-4 24840884-1 2014 PURPOSE OF REVIEW: The purpose of this review is to describe the renin-angiotensin-aldosterone system and its regulatory control of sodium, potassium, chloride, hydrogen ion, and water homeostasis through its effects on the expression and activity of distal renal tubular cotransporter proteins and to discuss the gene mutations encoding these structures that disturb the function of this system. Potassium 140-149 renin Homo sapiens 65-70 25254266-6 2014 A 1 muM LOD for sodium and a 1.6 muM LOD for potassium ions were revealed for the detector. Potassium 45-54 latexin Homo sapiens 4-7 25254266-6 2014 A 1 muM LOD for sodium and a 1.6 muM LOD for potassium ions were revealed for the detector. Potassium 45-54 latexin Homo sapiens 33-36 24694645-10 2014 Six SNPs in WNK1 (rs11064524, rs4980973, rs12581940, rs880054, rs953361, and rs10849582) were correlated with decreases in serum potassium. Potassium 129-138 WNK lysine deficient protein kinase 1 Homo sapiens 12-16 24694645-13 2014 Multivariate stepwise linear regression analysis revealed that the changes in serum potassium levels were independently associated with the baseline potassium level (beta=-0.587, 95% confidence interval=-0.875--0.299, P=0.0001) and WNK1 rs4980973 (A/A and A/G vs. G/G, beta=-0.418, 95% confidence interval=-0.598--0.237, P=0.00002). Potassium 84-93 WNK lysine deficient protein kinase 1 Homo sapiens 232-236 24694645-13 2014 Multivariate stepwise linear regression analysis revealed that the changes in serum potassium levels were independently associated with the baseline potassium level (beta=-0.587, 95% confidence interval=-0.875--0.299, P=0.0001) and WNK1 rs4980973 (A/A and A/G vs. G/G, beta=-0.418, 95% confidence interval=-0.598--0.237, P=0.00002). Potassium 149-158 WNK lysine deficient protein kinase 1 Homo sapiens 232-236 24694645-14 2014 In conclusion, the baseline potassium level and the WNK1 rs4980973 polymorphism were independent predictors of decreases in serum potassium after short-term hydrochlorothiazide treatment in nondiabetic hypertensive patients. Potassium 130-139 WNK lysine deficient protein kinase 1 Homo sapiens 52-56 24866132-8 2014 Patients with KCNJ5 mutations were more frequently female, diagnosed younger, and with higher minimal plasma potassium concentrations compared with CACNA1D mutation carriers or noncarriers. Potassium 109-118 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 14-19 24947509-2 2014 Assembled with the beta-subunit KCNE1, Kv7.1 conducts the slowly activating potassium current IKs, which is one of the major currents underlying repolarization of the cardiac action potential. Potassium 76-85 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 39-44 24678923-1 2014 INTRODUCTION: KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (I(to,f)) in the heart. Potassium 121-130 Kv channel-interacting protein 2 Mus musculus 33-65 24678923-1 2014 INTRODUCTION: KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (I(to,f)) in the heart. Potassium 121-130 Kv channel-interacting protein 2 Mus musculus 67-73 24753196-2 2014 Body cell mass (BCM) assessment using total body potassium (TBK) measurements is considered the gold standard for assessing nutritional status. Potassium 49-58 TNF receptor superfamily member 17 Homo sapiens 16-19 24769160-10 2014 The addition of the PKA inhibitor KT5720, the MAP kinase inhibitor U0126, and the PI3 kinase inhibitor LY294002 abrogated the GPR3-mediated antiapoptotic effect in a potassium-deprivation model of apoptosis, whereas the PKC inhibitor Go6976 did not affect the antiapoptotic function of GPR3. Potassium 166-175 G-protein coupled receptor 3 Mus musculus 126-130 24974804-3 2014 Reduction of the azabutadienyl chelate boron dichloride [ArN C(R)CH C(R)]BCl2 (2, Ar=2,6-Me2 C6 H3 , R=tBu) with two equivalents of potassium yielded the novel 2-chloro-azaborolyl anion [ArNC(R)CHC(R)BCl]K(thf) (3) as a stable product in good yield. Potassium 132-141 BCL2 apoptosis regulator Homo sapiens 73-77 24862110-1 2014 Ion-selective organic electrochemical transistors with sensitivity to potassium approaching 50 muA dec(-1) are demonstrated. Potassium 70-79 deleted in esophageal cancer 1 Homo sapiens 99-105 25056878-4 2014 When stimulated by potassium ions (K(+)), Panx1 formed a high-conductance channel of ~500 pS that was permeable to ATP. Potassium 19-28 pannexin 1 L homeolog Xenopus laevis 42-47 23844633-4 2014 Both types of LQTS can be caused by mutations in channel genes (e.g. KCNQ1) responsible for potassium homeostasis in cardiac myocytes and cochlea. Potassium 92-101 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 69-74 25077539-7 2014 This may explain why especially these cells appear to benefit from the preserved Kir4.1 expression in Muller cells, which should allow them to keep up their function in the context of spatial buffering of potassium. Potassium 205-214 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 81-87 24785188-0 2014 Sodium and potassium regulate endothelial phospholipase C-gamma and Bmx. Potassium 11-20 BMX non-receptor tyrosine kinase Rattus norvegicus 68-71 24143882-11 2014 The most compelling results were obtained with genes involved in potassium signaling pathways (e.g., KCNC1 and KCNG2). Potassium 65-74 potassium voltage-gated channel subfamily C member 1 Homo sapiens 101-106 24143882-11 2014 The most compelling results were obtained with genes involved in potassium signaling pathways (e.g., KCNC1 and KCNG2). Potassium 65-74 potassium voltage-gated channel modifier subfamily G member 2 Homo sapiens 111-116 24840790-2 2014 To identify the risk gene within the region we studied the potassium inwardly-rectifying channel J5 (KCNJ5) gene in a sample of 170 nuclear families with TS. Potassium 59-68 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 101-106 24501278-9 2014 Discovery of a functionally relevant novel de novo variant, coupled with physiological evidence that the mutant protein disrupts potassium current inactivation, strongly supports KCND2 as the causal gene for epilepsy in this family. Potassium 129-138 potassium voltage-gated channel subfamily D member 2 Homo sapiens 179-184 24573316-0 2014 Relation between BK-alpha/beta4-mediated potassium secretion and ENaC-mediated sodium reabsorption. Potassium 41-50 sodium channel, nonvoltage-gated 1 alpha Mus musculus 65-69 24573316-11 2014 Thus, the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption linked to bicarbonate secretion. Potassium 157-166 sodium channel, nonvoltage-gated 1 alpha Mus musculus 217-221 25058146-0 2014 Effect of salt intake and potassium supplementation on serum renalase levels in Chinese adults: a randomized trial. Potassium 26-35 renalase, FAD dependent amine oxidase Homo sapiens 61-69 25058146-5 2014 Renalase levels decreased with the change from the low-salt to high-salt diet, whereas dietary potassium prevented the decrease in serum renalase induced by the high-salt diet. Potassium 95-104 renalase, FAD dependent amine oxidase Homo sapiens 137-145 25058146-7 2014 No significant correlation was found between the renalase level and BP among the different dietary interventions.The present study indicates that variations in dietary salt intake and potassium supplementation affect the serum renalase concentration in Chinese subjects. Potassium 184-193 renalase, FAD dependent amine oxidase Homo sapiens 227-235 24748648-8 2014 Moreover, we corroborated the ciliary localization of the potassium-dependent Na(+)/Ca(2+) exchanger (NCKX) 4 and the plasma membrane Ca(2+)-ATPase 1 (PMCA1) involved in olfactory signal termination, and we detected for the first time NCKX2 in olfactory cilia. Potassium 58-67 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Mus musculus 78-109 24748648-8 2014 Moreover, we corroborated the ciliary localization of the potassium-dependent Na(+)/Ca(2+) exchanger (NCKX) 4 and the plasma membrane Ca(2+)-ATPase 1 (PMCA1) involved in olfactory signal termination, and we detected for the first time NCKX2 in olfactory cilia. Potassium 58-67 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Mus musculus 235-240 24748657-3 2014 The present investigation used photolysis of two caged opioid ligands to examine the kinetics of MOR-induced potassium conductance before and after MOR desensitization. Potassium 109-118 opioid receptor mu 1 Homo sapiens 97-100 32261727-3 2014 In the present study, a synthetic peptide whose sequence is from the fourth transmembrane segment of TRPV4 is found that is capable of self-assembling into potassium (K+)-like ion channels designated as TRP-PK1 in the membranes of liposomes and live cells. Potassium 156-165 transient receptor potential cation channel subfamily V member 4 Homo sapiens 101-106 24619705-6 2014 Potassium efflux, activation of P2X7 receptor and intracellular reactive oxygen speciesare also important factors required for fullerenols-induced IL-1beta release. Potassium 0-9 interleukin 1 beta Mus musculus 147-155 24894994-4 2014 Lowering the concentration of extracellular potassium, a condition that reduces neuronal excitability, stimulated depletion of intracellular Ca(2+) stores, resulted in the relocalization of the ER Ca(2+) sensor STIM1 into punctate clusters consistent with multimerization and accumulation at junctions between the ER and plasma membrane, and induced a Ca(2+) influx with characteristics of SOCE. Potassium 44-53 stromal interaction molecule 1 Homo sapiens 211-216 24894994-5 2014 Compounds that block SOCE prevented the ubiquitylation and degradation of Sp4 in neurons exposed to a low concentration of extracellular potassium. Potassium 137-146 Sp4 transcription factor Homo sapiens 74-77 24361620-8 2014 The binding of azoles to zebrafish CYP51 gave KS (dissociation constant) values of 0.26muM for ketoconazole and 0.64muM for propiconazole. Potassium 46-48 cytochrome P450, family 51 Danio rerio 35-40 24671621-9 2014 Our findings suggest that hair mineral concentrations, such as calcium, magnesium, zinc, sodium, and potassium concentrations, may play a role in the development of insulin resistance. Potassium 101-110 insulin Homo sapiens 165-172 28510183-5 2014 Many studies have also demonstrated that CFTR also regulates channel pore opening and the transport of sodium, chloride and potassium. Potassium 124-133 CF transmembrane conductance regulator Homo sapiens 41-45 24738991-8 2014 Multivariate analysis adjusted for age and fibrinogen showed that in MM patients elevated peak thrombin levels determine Ks and D-Dmax , while thrombin-activatable fibrinolysis inhibitor (TAFI) activity predicts Ks , t50% , D-Drate and lag phase. Potassium 121-123 coagulation factor II, thrombin Homo sapiens 95-103 24738991-8 2014 Multivariate analysis adjusted for age and fibrinogen showed that in MM patients elevated peak thrombin levels determine Ks and D-Dmax , while thrombin-activatable fibrinolysis inhibitor (TAFI) activity predicts Ks , t50% , D-Drate and lag phase. Potassium 212-214 carboxypeptidase B2 Homo sapiens 143-186 24738991-8 2014 Multivariate analysis adjusted for age and fibrinogen showed that in MM patients elevated peak thrombin levels determine Ks and D-Dmax , while thrombin-activatable fibrinolysis inhibitor (TAFI) activity predicts Ks , t50% , D-Drate and lag phase. Potassium 212-214 carboxypeptidase B2 Homo sapiens 188-192 24525029-6 2014 Additionally, exogenous cystine crystals were internalized by monocytes, and inhibition of phagocytosis, cathepsin B leakage, generation of reactive oxygen species, and potassium efflux reduced cystine crystal-induced IL-1beta secretion. Potassium 169-178 interleukin 1 beta Homo sapiens 218-226 24836577-4 2014 In mice with cardiac Bin1 deletion, T-tubule folding is decreased, which does not change overall cardiomyocyte morphology but leads to free diffusion of local extracellular calcium and potassium ions, prolonging action-potential duration and increasing susceptibility to ventricular arrhythmias. Potassium 185-194 bridging integrator 1 Mus musculus 21-25 24869750-15 2014 This is based on an informal indirect comparison of results observed in other Cochrane reviews on ACE inhibitors, ARBs and renin inhibitors compared with placebo, which used similar inclusion/exclusion criteria to the present review.Thiazides reduced potassium, increased uric acid and increased total cholesterol and triglycerides. Potassium 251-260 angiotensin I converting enzyme Homo sapiens 98-101 24855268-5 2014 RNA interference with FoxP expression in alphabeta core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. Potassium 97-106 Forkhead box P Drosophila melanogaster 155-159 24886734-7 2014 Protein, vitamin B12, zinc, potassium and dairy intake were all positively correlated with higher BMD while dairy and potassium intakes also inversely correlated with CTX. Potassium 118-127 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 167-170 24916350-9 2014 The subcellular colocalization of Kir4.1 and AQP4 in epithelial supporting cells indicates functional coupling of potassium and water flow in the cochlea. Potassium 114-123 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 34-40 24916350-9 2014 The subcellular colocalization of Kir4.1 and AQP4 in epithelial supporting cells indicates functional coupling of potassium and water flow in the cochlea. Potassium 114-123 aquaporin 4 Homo sapiens 45-49 24831221-2 2014 In most vertebrates, including humans, Muller cells abundantly express Kir4.1 inwardly rectifying potassium channels responsible for hyperpolarized membrane potential and for various vital functions such as potassium buffering and glutamate clearance; inter-species differences in Kir4.1 expression were, however, observed. Potassium 98-107 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 71-77 24831221-2 2014 In most vertebrates, including humans, Muller cells abundantly express Kir4.1 inwardly rectifying potassium channels responsible for hyperpolarized membrane potential and for various vital functions such as potassium buffering and glutamate clearance; inter-species differences in Kir4.1 expression were, however, observed. Potassium 98-107 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 281-287 24655003-5 2014 Insulin- and low-potassium diet-induced NCC phosphorylation were abolished in WNK4-/- mice, establishing that both signals to NCC were mediated by WNK4. Potassium 17-26 WNK lysine deficient protein kinase 4 Mus musculus 78-82 24655003-5 2014 Insulin- and low-potassium diet-induced NCC phosphorylation were abolished in WNK4-/- mice, establishing that both signals to NCC were mediated by WNK4. Potassium 17-26 WNK lysine deficient protein kinase 4 Mus musculus 147-151 24803536-2 2014 WNK1 is at the top of a kinase cascade, leading to phosphorylation of several cotransporters, in particular those transporting sodium, potassium, and chloride (NKCC), sodium and chloride (NCC), and potassium and chloride (KCC). Potassium 135-144 WNK lysine deficient protein kinase 1 Homo sapiens 0-4 24606883-7 2014 In vitro experiments showed that extracellular adenosine triphosphate (ATP) induced inflammasome activation in CD epithelial cells through P2X7-potassium efflux and reactive oxygen species-dependent pathways. Potassium 144-153 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 139-143 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Potassium 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-81 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Potassium 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 24712483-2 2014 Recent studies indicate that AQP4 regulates various biological functions of astrocytes, including maintaining CNS water balance, spatial buffering of extracellular potassium, calcium signal transduction, regulation of neurotransmission, synaptic plasticity, and adult neurogenesis, while under neuropathological conditions, AQP4 has a role in astrogliosis and proinflammatory cytokine secretion. Potassium 164-173 aquaporin 4 Homo sapiens 29-33 24594434-10 2014 Overall, our data indicate that intracellular SVCT2 is localized in mitochondria, is sensitive to an intracellular microenvironment low in sodium and high in potassium, and functions as a low-affinity ascorbic acid transporter. Potassium 158-167 solute carrier family 23 member 2 Homo sapiens 46-51 24594434-8 2014 Further studies using HEK-293 cells overexpressing SVCT2 at the plasma membrane revealed that the altered kinetic properties of mitochondrial SVCT2 are due to the ionic intracellular microenvironment (low in sodium and high in potassium), with potassium acting as a concentration-dependent inhibitor of SVCT2. Potassium 227-236 solute carrier family 23 member 2 Homo sapiens 51-56 24594434-8 2014 Further studies using HEK-293 cells overexpressing SVCT2 at the plasma membrane revealed that the altered kinetic properties of mitochondrial SVCT2 are due to the ionic intracellular microenvironment (low in sodium and high in potassium), with potassium acting as a concentration-dependent inhibitor of SVCT2. Potassium 227-236 solute carrier family 23 member 2 Homo sapiens 142-147 24594434-8 2014 Further studies using HEK-293 cells overexpressing SVCT2 at the plasma membrane revealed that the altered kinetic properties of mitochondrial SVCT2 are due to the ionic intracellular microenvironment (low in sodium and high in potassium), with potassium acting as a concentration-dependent inhibitor of SVCT2. Potassium 227-236 solute carrier family 23 member 2 Homo sapiens 142-147 24048291-9 2014 Plasma renin activity and serum aldosterone both increased with potassium (P=0.001 and P=0.048 respectively). Potassium 64-73 renin Homo sapiens 7-12 24509840-1 2014 TWIK-related K(+) 1 (TREK1) potassium channels are members of the two-pore domain potassium channel family and contribute to background potassium conductances in many cell types, where their activity can be regulated by a variety of physiologic and pharmacologic mediators. Potassium 28-37 potassium two pore domain channel subfamily K member 2 Homo sapiens 0-19 24509840-1 2014 TWIK-related K(+) 1 (TREK1) potassium channels are members of the two-pore domain potassium channel family and contribute to background potassium conductances in many cell types, where their activity can be regulated by a variety of physiologic and pharmacologic mediators. Potassium 28-37 potassium two pore domain channel subfamily K member 2 Homo sapiens 21-26 24046152-10 2014 The electrophysiological study showed that leptin increases the fast transient outward potassium current amplitudes and densities shortening action potential duration. Potassium 87-96 leptin Rattus norvegicus 43-49 25016399-8 2014 Although approximately 70% of patients with uncontrolled TRH have estimated glomerular filtration rate of 50 or greater and a serum potassium level of 4.5 or less, which are associated with a low risk for hyperkalemia, only a small percentage receive a mineralocorticoid-receptor antagonist. Potassium 132-141 thyrotropin releasing hormone Homo sapiens 57-60 25016402-9 2014 The adverse electrolyte and renal function side effects with aldosterone-receptor antagonists are not uncommon in at-risk patients, such as those with chronic kidney disease, and require that dosing be mindful of the tendency of these drugs to importantly increase serum potassium levels. Potassium 271-280 nuclear receptor subfamily 3 group C member 2 Homo sapiens 61-81 24703839-4 2014 SOD1(A4V/+) ALS patient-derived motor neurons have reduced delayed-rectifier potassium current amplitudes relative to control-derived motor neurons, a deficit that may underlie their hyperexcitability. Potassium 77-86 superoxide dismutase 1 Homo sapiens 0-4 24517838-3 2014 Zero-net flux microdialysis results showed that female BDNF(+/-) mice had increased striatal extracellular dopamine levels, while stimulated regional release by high potassium concentrations potentiated dopamine release through vesicular-mediated depolarization. Potassium 166-175 brain derived neurotrophic factor Mus musculus 55-59 24719109-2 2014 However, despite an abundance of evidence demonstrating that KCNQ2/3 heteromers underlie critical potassium conductances, it is unknown whether KCNQ2, KCNQ3, or both are obligatory for maintaining normal pyramidal neuron excitability. Potassium 98-107 potassium voltage-gated channel, subfamily Q, member 2 Mus musculus 61-66 24694658-3 2014 Here we show that the inhibition of Panx1 by ATP is abrogated by increased extracellular potassium ion concentration ([K(+)]o) in a dose-dependent manner. Potassium 89-98 pannexin 1 Homo sapiens 36-41 23912897-5 2014 The MMP23 pro-domain can trap Kv1.3 but not closely-related Kv1.2 channels in the endoplasmic reticulum, preventing their passage to the cell surface, while the TxD can bind to the channel pore and block the passage of potassium ions. Potassium 219-228 matrix metallopeptidase 23B Homo sapiens 4-9 24699751-1 2014 The Arabidopsis thaliana K(+) transporter 1 (AKT1) participates in the maintenance of an adequate cell potassium (K(+)) concentration. Potassium 103-112 K+ transporter 1 Arabidopsis thaliana 4-43 24699751-1 2014 The Arabidopsis thaliana K(+) transporter 1 (AKT1) participates in the maintenance of an adequate cell potassium (K(+)) concentration. Potassium 103-112 K+ transporter 1 Arabidopsis thaliana 45-49 24721657-1 2014 Co-assembly of KCNQ1 with KCNE1 generates the IKS potassium current that is vital for the proper repolarization of the cardiac action potential. Potassium 50-59 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 15-20 24721657-1 2014 Co-assembly of KCNQ1 with KCNE1 generates the IKS potassium current that is vital for the proper repolarization of the cardiac action potential. Potassium 50-59 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 26-31 24494598-7 2014 Delayed rectifier potassium current is diminished in hippocampal neurons cultured from Kv2.1(-/-) animals. Potassium 18-27 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 87-92 24357532-6 2014 KCNQ1 mutation carriers showed increased insulin release (area under the curve 45.6 +- 6.3 vs. 26.0 +- 2.8 min nmol/L insulin) and beta-cell glucose sensitivity and had lower levels of plasma glucose and serum potassium upon oral glucose stimulation and increased hypoglycemic symptoms. Potassium 212-221 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-5 24357532-8 2014 The phenotype of patients with KCNQ1 LQTS, caused by mutations in KCNQ1, includes, besides long QT, hyperinsulinemia, clinically relevant symptomatic reactive hypoglycemia, and low potassium after an oral glucose challenge, suggesting that KCNQ1 mutations may explain some cases of "essential" reactive hypoglycemia. Potassium 181-190 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 31-36 24357532-8 2014 The phenotype of patients with KCNQ1 LQTS, caused by mutations in KCNQ1, includes, besides long QT, hyperinsulinemia, clinically relevant symptomatic reactive hypoglycemia, and low potassium after an oral glucose challenge, suggesting that KCNQ1 mutations may explain some cases of "essential" reactive hypoglycemia. Potassium 181-190 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 66-71 24357532-8 2014 The phenotype of patients with KCNQ1 LQTS, caused by mutations in KCNQ1, includes, besides long QT, hyperinsulinemia, clinically relevant symptomatic reactive hypoglycemia, and low potassium after an oral glucose challenge, suggesting that KCNQ1 mutations may explain some cases of "essential" reactive hypoglycemia. Potassium 181-190 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 66-71 24258360-6 2014 The permeability coefficient Ks decreased significantly after FVIII treatment. Potassium 29-31 coagulation factor VIII Homo sapiens 62-67 24258360-7 2014 Ks correlated significantly with FVIII levels and dosage, and with ETP, OHP and levels of TAFI. Potassium 0-2 coagulation factor VIII Homo sapiens 33-38 24258360-7 2014 Ks correlated significantly with FVIII levels and dosage, and with ETP, OHP and levels of TAFI. Potassium 0-2 carboxypeptidase B2 Homo sapiens 90-94 24318194-9 2014 INTERPRETATION: The development of severe epilepsy and cognitive decline in children carrying 5 of the 7 studied KCNQ2 mutations can be related to a dominant-negative reduction of the resulting potassium current at subthreshold membrane potentials. Potassium 194-203 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 113-118 24643009-4 2014 In particular, we study the coordination of the different ligands, the gating mechanism and the location of the proton and potassium binding sites in EAAT3. Potassium 123-132 solute carrier family 1 member 1 Homo sapiens 150-155 24643009-7 2014 Finally, we perform free energy calculations to locate the potassium binding site in EAAT3, and find a high-affinity site that overlaps with the Na1 and Na3 sites in GltPh. Potassium 59-68 solute carrier family 1 member 1 Homo sapiens 85-90 24606761-1 2014 BACKGROUND: The human ether-a-go-go related gene 1 (hERG1), which codes for a potassium ion channel, is a key element in the cardiac delayed rectified potassium current, IKr, and plays an important role in the normal repolarization of the heart"s action potential. Potassium 78-87 potassium voltage-gated channel subfamily H member 2 Homo sapiens 52-57 24388921-0 2014 Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone. Potassium 97-106 brain-derived neurotrophic factor Rattus norvegicus 22-55 24520048-4 2014 Here, we demonstrate the use of NMR spectroscopy to characterise binding of ammonium ions to two different enzymes: human histone deacetylase 8 (HDAC8), which is activated allosterically by potassium, and the bacterial Hsp70 homologue DnaK, for which potassium is an integral part of the active site. Potassium 190-199 histone deacetylase 8 Homo sapiens 122-143 24520048-4 2014 Here, we demonstrate the use of NMR spectroscopy to characterise binding of ammonium ions to two different enzymes: human histone deacetylase 8 (HDAC8), which is activated allosterically by potassium, and the bacterial Hsp70 homologue DnaK, for which potassium is an integral part of the active site. Potassium 190-199 histone deacetylase 8 Homo sapiens 145-150 24520048-4 2014 Here, we demonstrate the use of NMR spectroscopy to characterise binding of ammonium ions to two different enzymes: human histone deacetylase 8 (HDAC8), which is activated allosterically by potassium, and the bacterial Hsp70 homologue DnaK, for which potassium is an integral part of the active site. Potassium 251-260 histone deacetylase 8 Homo sapiens 122-143 24520048-4 2014 Here, we demonstrate the use of NMR spectroscopy to characterise binding of ammonium ions to two different enzymes: human histone deacetylase 8 (HDAC8), which is activated allosterically by potassium, and the bacterial Hsp70 homologue DnaK, for which potassium is an integral part of the active site. Potassium 251-260 histone deacetylase 8 Homo sapiens 145-150 24520048-4 2014 Here, we demonstrate the use of NMR spectroscopy to characterise binding of ammonium ions to two different enzymes: human histone deacetylase 8 (HDAC8), which is activated allosterically by potassium, and the bacterial Hsp70 homologue DnaK, for which potassium is an integral part of the active site. Potassium 251-260 heat shock protein family A (Hsp70) member 4 Homo sapiens 219-224 23405890-8 2014 With the reduction in serum potassium level, participants have larger waist circumference (WC) and more severe insulin resistance. Potassium 28-37 insulin Homo sapiens 111-118 23405890-10 2014 In logistic regression analysis, compared with subjects in the highest quartile of serum potassium level, the adjusted odds ratios (ORs) in the lowest quartile was 1 33 [95% confidence interval (CI), 1 11-1 60] for NAFLD, 1 81 (95% CI, 1 49-2 19) for insulin resistance and 1 58 (95% CI, 1 30-1 93) for central obesity. Potassium 89-98 insulin Homo sapiens 251-258 23405890-11 2014 In subgroup analysis after multiple adjustments, significant relation between serum potassium level and prevalent NAFLD was detected in women, younger subjects, those with insulin resistance and those with central obesity, respectively. Potassium 84-93 insulin Homo sapiens 172-179 24337990-9 2014 Denuder-fitted PM1 sampler can serve as a useful sampling tool in estimating the true values for nitrate, ammonium, potassium, sodium and WSOC present in the ambient PM. Potassium 116-125 transmembrane protein 11 Homo sapiens 15-18 24138091-7 2014 HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel. Potassium 63-72 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 23-28 24138091-7 2014 HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel. Potassium 63-72 caspase 1 Homo sapiens 130-139 24138091-7 2014 HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel. Potassium 63-72 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 237-242 24203997-5 2014 Of note, mTORC1 activation also reduced the expression of serum- and glucocorticoid-inducible kinase 1, a crucial regulator of potassium homeostasis in the kidney, and decreased the expression and/or activity of epithelial sodium channel-alpha, renal outer medullary potassium channel, and Na(+), K(+)-ATPase in the CD, which probably contributed to the aldosterone resistance and hyperkalemia in these mice. Potassium 127-136 CREB regulated transcription coactivator 1 Mus musculus 9-15 24203997-7 2014 Overall, this study identifies a novel function of mTORC1 in regulating potassium homeostasis and demonstrates that loss of TSC1 and activation of mTORC1 results in dedifferentiation and dysfunction of the CD and causes hyperkalemia. Potassium 72-81 CREB regulated transcription coactivator 1 Mus musculus 51-57 24203997-7 2014 Overall, this study identifies a novel function of mTORC1 in regulating potassium homeostasis and demonstrates that loss of TSC1 and activation of mTORC1 results in dedifferentiation and dysfunction of the CD and causes hyperkalemia. Potassium 72-81 TSC complex subunit 1 Mus musculus 124-128 24506953-6 2014 Stimulation with high potassium induced calcium-dependent and reversible CGRP release. Potassium 22-31 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 73-77 24203997-2 2014 However, the role of mTOR in renal potassium excretion and hyperkalemia is not known. Potassium 35-44 mechanistic target of rapamycin kinase Mus musculus 21-25 24882402-7 2014 Licorice-induced pseudoaldosteronism develops due to the inhibition of type 2 11beta-hydrosteroid dehydrogenase (11beta-HSD2) which results in the accumulation of cortisol in tubular epithelial cells that activate mineral corticoid receptors to stimulate the excretion of potassium that results in hypokalemia. Potassium 272-281 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 113-124 24238269-7 2014 However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1. Potassium 98-107 interleukin 1 beta Homo sapiens 33-41 24238269-7 2014 However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1. Potassium 98-107 caspase 1 Homo sapiens 207-216 24408119-0 2014 Serum potassium in dual renin-angiotensin-aldosterone system blockade. Potassium 6-15 renin Homo sapiens 24-29 23884315-7 2014 The mechanism of P. acnes-induced NLRP3 activation and subsequent IL-1beta secretion was found to involve potassium efflux. Potassium 106-115 NLR family pyrin domain containing 3 Homo sapiens 34-39 23884315-7 2014 The mechanism of P. acnes-induced NLRP3 activation and subsequent IL-1beta secretion was found to involve potassium efflux. Potassium 106-115 interleukin 1 beta Homo sapiens 66-74 24134393-7 2014 Impairment of the CMR1 activity alters root growth through aberrant activity of the root meristem, and modifies potassium concentration and hormonal balance (ethylene production and auxin accumulation). Potassium 112-121 hypothetical protein Arabidopsis thaliana 18-22 24478370-5 2014 In addition, we show that enhanced intracellular Ca(2+) responses to depolarization with potassium are prevented by the treatment with the tPA-neutralizing antibody in FMRP-deficient cells during early neural progenitor differentiation. Potassium 89-98 plasminogen activator, tissue Mus musculus 139-142 24478370-5 2014 In addition, we show that enhanced intracellular Ca(2+) responses to depolarization with potassium are prevented by the treatment with the tPA-neutralizing antibody in FMRP-deficient cells during early neural progenitor differentiation. Potassium 89-98 fragile X messenger ribonucleoprotein 1 Mus musculus 168-172 24388850-9 2014 Ka/Ks analyses indicate relatively rapid evolution of GEX2, like other proteins involved in male and female interactions. Potassium 3-5 gamete expressed 2 Arabidopsis thaliana 54-58 24369856-2 2014 Although the epitaxially guided collagen assembly mediated by potassium ion on mica surface has been reported several times over these years, specific effects of anions in this field has never been surveyed and discussed before now. Potassium 62-71 MHC class I polypeptide-related sequence A Homo sapiens 79-83 25693308-1 2014 This study explored the mechanism of electro-acupuncture (EA) at PC6 to improve the heart function by regulating the cardiac transient outward potassium current (= Ito) channel in myocardial ischemia (MI). Potassium 143-152 proprotein convertase subtilisin/kexin type 5 Rattus norvegicus 65-68 24233492-6 2014 A significant decrease in a voltage-dependent K(+) channel, Kv1.5 protein, and an increase in intracellular potassium levels were demonstrated in Nox1(-/Y) PASMCs. Potassium 108-117 NADPH oxidase 1 Mus musculus 146-150 24233492-8 2014 CONCLUSIONS: These findings suggest a critical role for NOX1 in cellular apoptosis by regulating Kv1.5 and intracellular potassium levels. Potassium 121-130 NADPH oxidase 1 Mus musculus 56-60 25483840-4 2014 We report here that guanine-rich TFOs partially substituted with 8-aza-7-deaza-guanine (PPG) have improved target site binding in potassium compared with TFOs containing the natural guanine base. Potassium 130-139 serglycin Homo sapiens 88-91 25115184-3 2014 The absence or pharmacological blockade of mitochondrial Cx43 (mtCx43) reduces dye and potassium uptake. Potassium 87-96 gap junction protein, alpha 1 Rattus norvegicus 57-61 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 2 Homo sapiens 60-66 24021239-0 2014 Role of Saccharomyces cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels. Potassium 72-81 Trk1p Saccharomyces cerevisiae S288C 33-37 24021239-0 2014 Role of Saccharomyces cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels. Potassium 115-124 Trk1p Saccharomyces cerevisiae S288C 33-37 24021239-3 2014 By using yeasts lacking the Trk1,2 system or expressing different versions of the mutated main plasma membrane potassium transporter (Trk1), we show that Trk1 is not essential for adaptation to potassium changes but the dynamics of potassium loss is very different in the wild type and in trk1,2 mutant or in yeasts expressing Trk1 versions with highly impaired transport characteristics. Potassium 111-120 Trk1p Saccharomyces cerevisiae S288C 134-138 24021239-3 2014 By using yeasts lacking the Trk1,2 system or expressing different versions of the mutated main plasma membrane potassium transporter (Trk1), we show that Trk1 is not essential for adaptation to potassium changes but the dynamics of potassium loss is very different in the wild type and in trk1,2 mutant or in yeasts expressing Trk1 versions with highly impaired transport characteristics. Potassium 111-120 Trk1p Saccharomyces cerevisiae S288C 134-138 24021239-3 2014 By using yeasts lacking the Trk1,2 system or expressing different versions of the mutated main plasma membrane potassium transporter (Trk1), we show that Trk1 is not essential for adaptation to potassium changes but the dynamics of potassium loss is very different in the wild type and in trk1,2 mutant or in yeasts expressing Trk1 versions with highly impaired transport characteristics. Potassium 111-120 Trk1p Saccharomyces cerevisiae S288C 289-293 24021239-3 2014 By using yeasts lacking the Trk1,2 system or expressing different versions of the mutated main plasma membrane potassium transporter (Trk1), we show that Trk1 is not essential for adaptation to potassium changes but the dynamics of potassium loss is very different in the wild type and in trk1,2 mutant or in yeasts expressing Trk1 versions with highly impaired transport characteristics. Potassium 111-120 Trk1p Saccharomyces cerevisiae S288C 134-138 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 2 Homo sapiens 68-74 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 2 Homo sapiens 75-80 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 10 Homo sapiens 91-98 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 10 Homo sapiens 99-105 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 4 Homo sapiens 119-125 25366235-1 2014 At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Potassium 41-50 potassium two pore domain channel subfamily K member 2 Homo sapiens 126-131 25322648-2 2014 Preliminary administration of the ACE inhibitor enalapril (1 mg/kg, p.o., for 7 days) enhances the renal dopamine response with 3.5-fold increase in its diuretic effect and increases natriuresis 3.2 times and urine potassium excretion 5 times (p < 0.05). Potassium 215-224 angiotensin I converting enzyme Rattus norvegicus 34-37 24185037-1 2013 TGA results indicated that the maximum decomposition temperature of the biomass decreased from 373.9 to 359.0 C with increasing potassium concentration. Potassium 128-137 T-box transcription factor 1 Homo sapiens 0-3 24267958-0 2014 Potassium uptake system Trk2 is crucial for yeast cell viability during anhydrobiosis. Potassium 0-9 Trk2p Saccharomyces cerevisiae S288C 24-28 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 152-161 Trk1p Saccharomyces cerevisiae S288C 65-69 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 152-161 Trk2p Saccharomyces cerevisiae S288C 74-78 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 152-161 Tok1p Saccharomyces cerevisiae S288C 238-242 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 152-161 Nha1p Saccharomyces cerevisiae S288C 287-291 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 209-218 Trk1p Saccharomyces cerevisiae S288C 65-69 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 209-218 Trk2p Saccharomyces cerevisiae S288C 74-78 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 209-218 Tok1p Saccharomyces cerevisiae S288C 238-242 24267958-3 2014 In the model yeast Saccharomyces cerevisiae, two uptake systems, Trk1 and Trk2, are responsible for the accumulation of a relatively high intracellular potassium content (200-300 mM) and the efflux of surplus potassium is mediated by the Tok1 channel and active exporters Ena ATPase and Nha1 cation/proton antiporter. Potassium 209-218 Nha1p Saccharomyces cerevisiae S288C 287-291 24267958-6 2014 Mutants lacking the TRK2 gene accumulated significantly lower amounts of potassium ions in the stationary culture growth phase, and these lower amounts correlated with decreased resistance to dehydration/rehydration stress. Potassium 73-82 Trk2p Saccharomyces cerevisiae S288C 20-24 24267958-7 2014 Our results showed Trk2 to be the major potassium uptake system in stationary cells, and potassium content to be a crucial parameter for desiccation survival. Potassium 40-49 Trk2p Saccharomyces cerevisiae S288C 19-23 24220548-5 2014 The effect of the heptapeptide on potassium current was inhibited by a Mas receptor inhibitor (A779; 10(-8) M) as well as by a protein kinase A (PKA) inhibitor (10(-9) M) dialyzed into the cell. Potassium 34-43 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 127-143 24220548-5 2014 The effect of the heptapeptide on potassium current was inhibited by a Mas receptor inhibitor (A779; 10(-8) M) as well as by a protein kinase A (PKA) inhibitor (10(-9) M) dialyzed into the cell. Potassium 34-43 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 145-148 24220548-6 2014 Intracellular dialysis of the catalytic subunit of PKA (5 x 10(-8) M) enhanced the potassium current by 38% +- 3.4% (n = 14; P < .05) but did not abolish the effect of Ang (1-7). Potassium 83-92 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 51-54 24258619-3 2014 FXYD (FXYD domain-containing protein) 2, the gamma-subunit of NKA, is the first identified and the most abundant member of FXYD family, affecting the sodium/potassium affinity of NKA in the kidney. Potassium 157-166 tachykinin precursor 1 Homo sapiens 62-65 24258619-3 2014 FXYD (FXYD domain-containing protein) 2, the gamma-subunit of NKA, is the first identified and the most abundant member of FXYD family, affecting the sodium/potassium affinity of NKA in the kidney. Potassium 157-166 tachykinin precursor 1 Homo sapiens 179-182 24081156-4 2014 The astroglial current is composed of three components sensitive to neuronal activity, i.e. a long-lasting potassium current mediated by Kir4.1 channels, a transient glutamate transporter current and a slow residual current, partially mediated by GABA transporters and Kir4.1-independent potassium channels. Potassium 107-116 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 137-143 24081156-7 2014 As Kir4.1 channel-mediated potassium uptake contributes to 80% of the synaptically evoked astroglial current, we investigated in turn its impact on short-term synaptic plasticity. Potassium 27-36 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 3-9 24081156-8 2014 Using glial conditional Kir4.1 knockout mice, we found that astroglial potassium uptake reduces synaptic responses to repetitive stimulation and post-tetanic potentiation. Potassium 71-80 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 24-30 24081156-9 2014 These results show that astrocytes integrate synaptic activity via multiple ionic channels and transporters and contribute to short-term plasticity in part via potassium clearance mediated by Kir4.1 channels. Potassium 160-169 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 192-198 25531090-0 2014 Genetic variants in renalase and blood pressure responses to dietary salt and potassium interventions: a family-based association study. Potassium 78-87 renalase, FAD dependent amine oxidase Homo sapiens 20-28 25531090-3 2014 The aim of this study was to examine the association between genetic variants in RNLS and blood pressure (BP) responses to strict dietary interventions of salt and potassium intake. Potassium 164-173 renalase, FAD dependent amine oxidase Homo sapiens 81-85 24268251-8 2014 The higher Ks value revealed that fast DET of GOx occurred at the electrode surface. Potassium 11-13 hydroxyacid oxidase 1 Homo sapiens 46-49 24310820-0 2014 The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation. Potassium 64-73 solute carrier family 12 member 3 Homo sapiens 34-41 24310820-5 2014 For example, the recent discoveries that NCC is activated by angiotensin II but inhibited by dietary potassium shed light on how the kidney handles sodium during hypovolemia (high angiotensin II) and hyperkalemia. Potassium 101-110 angiotensinogen Homo sapiens 180-194 25000676-2 2014 Ambulatory treatment with hypotensors, mainly angiotensin-renin system inhibitors, can be associated in these patients with potassium retention and risk of hyperkalemia. Potassium 124-133 renin Homo sapiens 58-63 25303187-5 2014 This study will investigate potassium intake and handling, and its impact on the cardiovascular health of a sample of normotensive Afro-Caribbeans by the possible modulation of the renin angiotensin aldosterone system (RAAS). Potassium 28-37 renin Homo sapiens 181-186 25303187-19 2014 This high potassium excretion could have been partly due to low plasma renin activity levels in the study participants. Potassium 10-19 renin Homo sapiens 71-76 24354396-7 2013 Leptin-treated LA myocytes showed a larger sodium current, but a smaller ultra-rapid delayed rectifier potassium current, and sodium-calcium exchanger current than the control. Potassium 103-112 leptin Oryctolagus cuniculus 0-6 24381583-9 2013 In mammals, Ka/Ks for BACE2 is higher than BACE1 but low ratios for both suggest purifying selection. Potassium 15-17 beta-secretase 2 Homo sapiens 22-27 24358289-4 2013 The Ka/Ks ratio (<1) and overall low level of nucleotide diversity in the FAE1 gene suggest that purifying selection is the major evolutionary force acting on this gene. Potassium 7-9 ELOVL fatty acid elongase 5 Homo sapiens 77-81 24514643-1 2013 Barium copper sulfur fluoride (BaCuSF) is a p-type transparent conductor (p-TC) that, when doped with potassium, exhibits exceptionally high conductivity. Potassium 102-111 coagulation factor IX Homo sapiens 44-78 24151244-9 2013 The effect of KCNJ11 observed on muscle is potentially due to changes in activity of KATP channels, which in turn influence the flow of potassium in the intracellular space, allowing establishment of the membrane potential necessary for muscle contraction. Potassium 136-145 potassium inwardly rectifying channel subfamily J member 11 Bos taurus 14-20 24314077-2 2013 Design of I(KS)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Potassium 12-14 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 102-107 24314077-2 2013 Design of I(KS)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Potassium 12-14 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 108-113 24314077-2 2013 Design of I(KS)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Potassium 12-14 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 192-197 23829355-1 2013 The G-protein-activated inwardly rectifying potassium channel Kir3.4 is expressed in the zona glomerulosa cell membrane and transports potassium out of the cell. Potassium 44-53 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 62-68 23829355-4 2013 In 40-60% of aldosterone-producing adenomas there is a somatic mutation in the region of the KCNJ5 gene that codes for the selectivity filter that decreases potassium selectivity, allowing sodium to leak into the cells, thus depolarizing the membrane and initiating events that result in increased aldosterone synthesis. Potassium 157-166 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 93-98 24052423-4 2013 Whereas the wild type and the tok1 mutant cells exhibited similar depolarization curves, mutant cells lacking the two Trk1,2 potassium transporters revealed a significantly decreased membrane depolarization by K(+), particularly at lower extracellular potassium concentration [K(+)]out. Potassium 126-135 Trk1p Saccharomyces cerevisiae S288C 119-123 23684954-9 2013 These potentially powerful roles expand the influence of AQP4 and astrocytes beyond the original suggestions related to regulation of extracellular potassium and water balance. Potassium 148-157 aquaporin 4 Mus musculus 57-61 23760292-0 2013 Partial genetic deficiency in tissue kallikrein impairs adaptation to high potassium intake in humans. Potassium 75-84 kallikrein 1 Homo sapiens 30-47 23760292-1 2013 Inactivation of the tissue kallikrein gene in mice impairs renal handling of potassium due to enhanced H, K-ATPase activity, and induces hyperkalemia. Potassium 77-86 kallikrein 1 Homo sapiens 20-37 23760292-10 2013 Thus, impaired tissue kallikrein stimulation by a low-sodium/high-potassium diet in R53H subjects with partial tissue kallikrein deficiency highlights an inappropriate renal adaptation to potassium load, consistent with experimental data in mice. Potassium 66-75 kallikrein 1 Homo sapiens 15-32 23760292-10 2013 Thus, impaired tissue kallikrein stimulation by a low-sodium/high-potassium diet in R53H subjects with partial tissue kallikrein deficiency highlights an inappropriate renal adaptation to potassium load, consistent with experimental data in mice. Potassium 188-197 kallikrein 1 Homo sapiens 15-32 24190995-3 2013 Here we show that intracellular ATP activates heterologously coexpressed KCNQ1 and KCNE1 as well as I(Ks) in cardiac myocytes by directly binding to the C terminus of KCNQ1 to allow the pore to open. Potassium 102-104 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 167-172 24089192-8 2013 In contrast, IL-1beta secretion is ablated by potassium, scavenging mitochondrial ROS, and both cathepsin B and caspase-1 inhibition. Potassium 46-55 interleukin 1 beta Homo sapiens 13-21 24244710-4 2013 Urinalysis indicated pronounced changes in LRRK2 knockout rats in urine specific gravity, total volume, urine potassium, creatinine, sodium, and chloride that started as early as 1- to 2-months of age. Potassium 110-119 leucine-rich repeat kinase 2 Rattus norvegicus 43-48 24233809-8 2013 Magnesium deficiency by interfering with ATPase functions causes increased intracellular calcium and sodium and decreases intracellular potassium concentration. Potassium 136-145 dynein axonemal heavy chain 8 Homo sapiens 41-47 24180323-5 2013 The present study investigated estrogen-mediated modulation of two voltage-gated potassium channel (Kv) subunits, Kv4.2 and Kv4.3, that are expressed predominantly in PVN neurons and the functional current of Kv4.2 and Kv4.3, the transient outward potassium current (IA). Potassium 81-90 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 114-119 24206565-8 2013 Potassium supplementation and sex hormone-based therapy may protect patients with LQT2. Potassium 0-9 potassium voltage-gated channel subfamily H member 2 Homo sapiens 82-86 24180323-5 2013 The present study investigated estrogen-mediated modulation of two voltage-gated potassium channel (Kv) subunits, Kv4.2 and Kv4.3, that are expressed predominantly in PVN neurons and the functional current of Kv4.2 and Kv4.3, the transient outward potassium current (IA). Potassium 81-90 potassium voltage-gated channel subfamily D member 3 Rattus norvegicus 124-129 23744741-5 2013 As expected, the swelling rate, Ks , decreased when increasing the crosslink density from 78.6 to 14.7 min-1 over a range of 1-20 mol% PEGDA indicating that diffusivity into the matrix is dependent on crosslink density. Potassium 32-34 CD59 molecule (CD59 blood group) Homo sapiens 103-108 24180234-8 2013 CONCLUSIONS: AtPAP2 overexpression resulted in a widespread reprogramming of the transcriptome in the transgenic plants, which is characterized by changes in the carbon, nitrogen, potassium, and iron metabolism. Potassium 180-189 Purple acid phosphatases superfamily protein Arabidopsis thaliana 13-19 24037327-0 2013 ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Potassium 14-23 ATP binding cassette subfamily C member 9 Homo sapiens 99-103 24108112-12 2013 In patients with CD, Ks and lysis time were independently predicted by fibrinogen and C-reactive protein. Potassium 21-23 fibrinogen beta chain Homo sapiens 71-81 24108112-12 2013 In patients with CD, Ks and lysis time were independently predicted by fibrinogen and C-reactive protein. Potassium 21-23 C-reactive protein Homo sapiens 86-104 23500045-8 2013 The results unambiguously show that the CREM sequence folds into a G-quadruplex structure in the presence of a physiological concentration of potassium ions. Potassium 142-151 cAMP responsive element modulator Homo sapiens 40-44 24400161-11 2013 Studies in Xenopus oocytes revealed that both S219R and L220F had a deleterious effect on ROMK-mediated potassium currents. Potassium 104-113 potassium inwardly rectifying channel subfamily J member 1 S homeolog Xenopus laevis 90-94 24012527-9 2013 It was determined that vindoline acted as a Kv2.1 inhibitor able to reduce the voltage-dependent outward potassium currents finally enhancing insulin secretion. Potassium 105-114 potassium voltage gated channel, Shab-related subfamily, member 1 Mus musculus 44-49 24055606-0 2013 Compromised potassium recycling in the cochlea contributes to conservation of endocochlear potential in a mouse model of age-related hearing loss. Potassium 12-21 cadherin 23 (otocadherin) Mus musculus 121-145 24133274-0 2013 Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation. Potassium 4-13 ETS transcription factor Mus musculus 0-3 24133274-0 2013 Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation. Potassium 4-13 glutamate receptor, metabotropic 1 Mus musculus 106-112 24116006-2 2013 Two-pore domain (K2P) potassium channels are background channels which enable the leak of potassium ions from cells. Potassium 22-31 keratin 76 Homo sapiens 17-20 24006450-4 2013 Coexpression of KCNQ1-S140G with KCNE1 generated potassium currents (S140G-IKs) that exhibited greater sensitivity to HMR-1556 than WT-IKs. Potassium 49-58 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 16-21 24006450-4 2013 Coexpression of KCNQ1-S140G with KCNE1 generated potassium currents (S140G-IKs) that exhibited greater sensitivity to HMR-1556 than WT-IKs. Potassium 49-58 potassium voltage-gated channel subfamily E member 1 Oryctolagus cuniculus 33-38 23893870-4 2013 Here we show reciprocal action of SDF-1alpha and LPA, on potassium currents through Kir2.1 channels in primary murine microglia. Potassium 57-66 potassium inwardly-rectifying channel, subfamily J, member 2 Mus musculus 84-90 23893820-6 2013 Electrophysiological recordings in acute cortical slices showed that at P5 a proportion of layer 4 microglia transiently express voltage-dependant potassium currents of the delayed rectifier family, mostly mediated by Kv1.3 subunits, which are usually expressed by activated microglia under pathological conditions. Potassium 147-156 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 218-223 24051376-1 2013 Inactivation of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to type I distal renal tubular acidosis (dRTA), a disease associated with salt- and potassium-losing nephropathy. Potassium 172-181 ATPase, H+ transporting, lysosomal V1 subunit B1 Mus musculus 44-52 23424208-9 2013 Our data indicated that the mechanism by which probucol inhibits I(Ks) was not mediated by the inhibition of cholesterol synthesis but depended on an interaction with the KCNQ1/KCNE1 complex. Potassium 67-69 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 171-176 23424208-9 2013 Our data indicated that the mechanism by which probucol inhibits I(Ks) was not mediated by the inhibition of cholesterol synthesis but depended on an interaction with the KCNQ1/KCNE1 complex. Potassium 67-69 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 177-182 23878373-1 2013 The largest outward potassium current in the soma of neocortical pyramidal neurons is due to channels containing Kv2.1 alpha subunits. Potassium 20-29 potassium voltage-gated channel subfamily B member 1 Rattus norvegicus 113-118 24137016-3 2013 Only recently has evidence accumulated to suggest that AQP4 is involved in such diverse functions as regulation of extracellular space volume, potassium buffering, cerebrospinal fluid circulation, interstitial fluid resorption, waste clearance, neuroinflammation, osmosensation, cell migration, and Ca(2+) signaling. Potassium 143-152 aquaporin 4 Homo sapiens 55-59 23963453-1 2013 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). Potassium 135-137 mitogen-activated protein kinase kinase kinase 2 Homo sapiens 0-5 23963453-1 2013 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). Potassium 135-137 mitogen-activated protein kinase kinase kinase 2 Homo sapiens 7-30 23963453-1 2013 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). Potassium 135-137 mitogen-activated protein kinase kinase kinase 2 Homo sapiens 7-10 23963453-1 2013 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). Potassium 135-137 mitogen-activated protein kinase kinase kinase 2 Homo sapiens 102-105 23893410-0 2013 Trypanosome Letm1 protein is essential for mitochondrial potassium homeostasis. Potassium 57-66 leucine zipper and EF-hand containing transmembrane protein 1 Homo sapiens 12-17 23893410-3 2013 Studies almost exclusively performed in opisthokonts have attributed several roles to Letm1, including maintaining mitochondrial morphology, mediating either calcium or potassium/proton antiport, and facilitating mitochondrial translation. Potassium 169-178 leucine zipper and EF-hand containing transmembrane protein 1 Homo sapiens 86-91 23893410-5 2013 We demonstrate that Letm1 is involved in maintaining mitochondrial volume via potassium/proton exchange across the inner membrane. Potassium 78-87 leucine zipper and EF-hand containing transmembrane protein 1 Homo sapiens 20-25 23741043-9 2013 These findings suggest that VIP regulates the long-term firing rate of SCN neurons through a VIPR2-mediated increase in the cAMP pathway and implicate the fast delayed rectifier (FDR) potassium currents as one of the targets of this regulation. Potassium 184-193 vasoactive intestinal polypeptide Mus musculus 28-31 23988599-9 2013 Beta-2-adrenergic agonists and several other medications can affect serum potassium levels; although the potential risks posed by the use of such drugs in patients with a history of HPP are unclear, cautious use in the context of known HPP is advised. Potassium 74-83 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 0-6 24039773-8 2013 Pre-treatment of neutrophils with specific inhibitors of the myeloid-restricted class I phosphatidylinositol-3-OH kinase (PI(3)K) isoforms showed that the EGF-CM from Mod/Sev asthmatics depended on the gamma (p<0.021) but not delta isoforms, while neutrophil survival required multiple class I PI(3)Ks. Potassium 302-304 epidermal growth factor Homo sapiens 155-158 23872451-9 2013 Adx+CSR rats also presented an increased function of 5-HT1A autoreceptors, since, in these rats, serotonin (1-10muM) produced a higher increase in the potassium dependent inward rectifying current in comparison with sham-operated animals. Potassium 151-160 5-hydroxytryptamine receptor 1A Rattus norvegicus 53-59 23735420-5 2013 The antihypertensive effect of potassium supplementation appears to occur through several mechanisms that include regulation of vascular sensitivity to catecholamines, promotion of natriuresis, limiting plasma renin activity, and improving endothelial function. Potassium 31-40 renin Homo sapiens 210-215 23711155-0 2013 Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. Potassium 16-25 developmentally regulated GTP binding protein 1 Homo sapiens 6-10 23859824-7 2013 In the case of CGNs deprived of depolarizing potassium (5K apoptotic condition), caspases appear to play a dominant role in CtBP downregulation. Potassium 45-54 poly(rC) binding protein 2 Mus musculus 124-128 23821668-5 2013 This site resembles structurally and functionally the potassium sites in the human FEN1 and exonuclease 1 enzymes. Potassium 54-63 flap structure-specific endonuclease 1 Homo sapiens 83-87 23821668-5 2013 This site resembles structurally and functionally the potassium sites in the human FEN1 and exonuclease 1 enzymes. Potassium 54-63 exonuclease 1 Homo sapiens 92-105 23792826-11 2013 The accumulation of the KS dehydrin was also responsive to exogenous ABA. Potassium 24-26 dehydrin Glycine max 27-35 23878078-2 2013 In this work, we provide evidence that AtHDA7, a HISTONE DEACETYLASE (HDAC) of the Reduced Potassium Dependency3 (RPD3) superfamily, is crucial for female gametophyte development and embryogenesis in Arabidopsis (Arabidopsis thaliana). Potassium 91-100 histone deacetylase7 Arabidopsis thaliana 39-45 23878078-2 2013 In this work, we provide evidence that AtHDA7, a HISTONE DEACETYLASE (HDAC) of the Reduced Potassium Dependency3 (RPD3) superfamily, is crucial for female gametophyte development and embryogenesis in Arabidopsis (Arabidopsis thaliana). Potassium 91-100 histone deacetylase Arabidopsis thaliana 49-68 23878078-2 2013 In this work, we provide evidence that AtHDA7, a HISTONE DEACETYLASE (HDAC) of the Reduced Potassium Dependency3 (RPD3) superfamily, is crucial for female gametophyte development and embryogenesis in Arabidopsis (Arabidopsis thaliana). Potassium 91-100 histone deacetylase Arabidopsis thaliana 70-74 23483653-2 2013 The additional role of PTS(Ntr) as a regulatory link between nitrogen and carbon utilization in Escherichia coli is assumed to be closely related to molecular functions of IIA(Ntr) in potassium homeostasis. Potassium 184-193 colicin Ia immunity protein Escherichia coli 172-175 23868291-4 2013 Homologous PNA readily invades a quadruplex derived from the promoter regulatory region found upstream of the MYC proto-oncogene to form a heteroquadruplex at high potassium concentration mimicking the intracellular environment, whereas complementary PNA exhibits virtually no hybridization. Potassium 164-173 MYC proto-oncogene, bHLH transcription factor Homo sapiens 110-113 23977150-0 2013 Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents. Potassium 47-56 potassium voltage-gated channel, subfamily Q, member 2 Mus musculus 11-16 23835093-6 2013 V1a agonist (Phe(2)-Ile(3)-Orn(8)-vasopressin) reproduced the renal effects of dAVT on sodium and potassium excretion but not on water reabsorption. Potassium 98-107 arginine vasopressin Rattus norvegicus 34-45 23515479-3 2013 The potassium atoms in ZBP-K are located near 8MR windows in the 2D zigzag channels, and the potassium cations are successfully exchanged with ammonium cations retaining the open-framework structure. Potassium 4-13 zona pellucida glycoprotein 4 Homo sapiens 23-26 23515479-3 2013 The potassium atoms in ZBP-K are located near 8MR windows in the 2D zigzag channels, and the potassium cations are successfully exchanged with ammonium cations retaining the open-framework structure. Potassium 93-102 zona pellucida glycoprotein 4 Homo sapiens 23-26 23711155-0 2013 Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. Potassium 16-25 zinc finger CCCH-type containing 15 Homo sapiens 55-62 23753405-1 2013 The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Potassium 26-35 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 45-49 23753405-1 2013 The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Potassium 26-35 potassium inwardly-rectifying channel, subfamily J, member 1 Rattus norvegicus 51-56 23753405-1 2013 The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Potassium 67-76 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 45-49 23753405-1 2013 The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Potassium 67-76 potassium inwardly-rectifying channel, subfamily J, member 1 Rattus norvegicus 51-56 23849528-10 2013 Regular insulin therapy may be more effective than infrequent large bolus therapy for potassium homeostasis. Potassium 86-95 insulin Homo sapiens 8-15 23774812-7 2013 Mineralocorticoid-receptor antagonists are associated with decreased mortality in patients with heart disease and show promise in patients with kidney injury, but can elevate serum potassium concentration. Potassium 181-190 nuclear receptor subfamily 3 group C member 2 Homo sapiens 0-26 23902721-10 2013 CONCLUSIONS: In this patient, CUL3 was found to play a fundamental role in the regulation of blood pressure, potassium levels, and acid-base balance. Potassium 109-118 cullin 3 Homo sapiens 30-34 23792956-4 2013 Our recent data indicate that hERG channels undergo enhanced endocytic degradation under low potassium (hypokalemia) conditions. Potassium 93-102 ETS transcription factor ERG Homo sapiens 30-34 23777398-1 2013 Measurements of aroxyl radical (ArO( ))-scavenging rate constants (ks(AOH)) of antioxidants (AOHs) (alpha-tocopherol (alpha-TocH), ubiquinol-10 (UQ10H2), and sodium ascorbate (Na(+)AsH(-))) were performed in 2-propanol/water (2-PrOH/H2O, 5/1, v/v) solution using stopped-flow spectrophotometry. Potassium 67-69 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 32-35 23678030-0 2013 Role of vasopressin in maintenance of potassium homeostasis in severe hemorrhage. Potassium 38-47 vasopressin Sus scrofa 8-19 23678030-4 2013 While it has been demonstrated for some time that vasopressin can influence secretion of potassium in the distal nephron, the magnitude of this effect and conditions under which this contributes to physiological modulation of potassium excretion has yet to be defined. Potassium 89-98 vasopressin Sus scrofa 50-61 23678030-5 2013 In this review, we assess the evidence that would suggest that vasopressin plays a key role in modulating potassium excretion and is important in the regulation of potassium homeostasis during hemorrhage. Potassium 106-115 vasopressin Sus scrofa 63-74 23678030-5 2013 In this review, we assess the evidence that would suggest that vasopressin plays a key role in modulating potassium excretion and is important in the regulation of potassium homeostasis during hemorrhage. Potassium 164-173 vasopressin Sus scrofa 63-74 25157205-4 2013 Recent studies in our laboratory indicate that brain aromatase activity is rapidly inhibited by an increase in intracellular calcium concentration resulting from potassium-induced depolarization or from the activation of glutamatergic receptors. Potassium 162-171 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 53-62 23861848-9 2013 Shortly after terminal ischemia/anoxia induction, the onset of a steep rise in the extracellular potassium concentration and an increase in lambda was faster in alpha-syn -/- mice, but the final values did not differ between alpha-syn -/- and alpha-syn +/+ mice. Potassium 97-106 synuclein, alpha Mus musculus 161-170 23604714-3 2013 The isometric contractions in the isolated second-order branch of mesenteric artery helical strips from CPI-17-Tg mice were significantly enhanced compared with controls in response to phenylephrine, U-46619, serotonin, ANG II, high potassium, and calcium. Potassium 233-242 protein phosphatase 1, regulatory inhibitor subunit 14A Mus musculus 104-110 23586466-6 2013 However, only potassium currents recorded in HEK 293 cells over-expressing both hSloalpha and hSlobeta1 were activated by oestrone, oestrone oxime and Quat DME-oestradiol. Potassium 14-23 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 80-103 23807092-2 2013 K(2P)3.1 and K(2P)9.1 leak potassium from the cell at rest and directly impact membrane potential. Potassium 27-36 potassium two pore domain channel subfamily K member 3 Homo sapiens 0-8 23807092-2 2013 K(2P)3.1 and K(2P)9.1 leak potassium from the cell at rest and directly impact membrane potential. Potassium 27-36 potassium two pore domain channel subfamily K member 9 Homo sapiens 13-21 23898345-7 2013 Normalization of the serum potassium level and disappearance of proteinuria were established with an ACE inhibitor and potassium supplementation. Potassium 27-36 angiotensin I converting enzyme Homo sapiens 101-104 23753530-8 2013 Ucn2 cotherapy additionally increased urine potassium and creatinine excretion. Potassium 44-53 urocortin-2 Ovis aries 0-4 23753530-9 2013 In contrast to the rise in plasma potassium induced by CA, Ucn2 cotreatment reduced potassium concentrations. Potassium 84-93 urocortin-2 Ovis aries 59-63 23753530-11 2013 Importantly, Ucn2 prevented CA-induced rises in plasma potassium. Potassium 55-64 urocortin-2 Ovis aries 13-17 23815537-0 2013 Salt loading and potassium supplementation: effects on ambulatory arterial stiffness index and endothelin-1 levels in normotensive and mild hypertensive patients. Potassium 17-26 endothelin 1 Homo sapiens 95-107 23815537-7 2013 High-salt intervention significantly increased BP, AASI, s-AASI (all P<.001); potassium supplementation reversed increased plasma ET-1 levels. Potassium 81-90 endothelin 1 Homo sapiens 133-137 23815537-9 2013 Potassium supplementation decreased systolic BP and ET-1 to a significantly greater extent in salt-sensitive vs non-salt-sensitive individuals (P<.001). Potassium 0-9 endothelin 1 Homo sapiens 52-56 23815537-10 2013 Significant correlations were identified between s-AASI and ET-1 change ratios in response to both high-salt intervention and potassium supplementation (P<.001). Potassium 126-135 endothelin 1 Homo sapiens 60-64 23853500-5 2013 Herein we present a 42-yr-old Korean male of DM1 with abnormally elevated serum sodium and potassium. Potassium 91-100 DM1 protein kinase Homo sapiens 45-48 23760924-0 2013 Connexin 43 impacts on mitochondrial potassium uptake. Potassium 37-46 gap junction protein, alpha 1 Mus musculus 0-11 23552867-4 2013 Potassium treatment increased the synthesis and excretion of tissue kallikrein (Klk1/rKLK1) accompanied by a significant reduction in blood pressure and renal fibrosis and with downregulation of renal transforming growth factor-beta (TGF-beta) mRNA and protein compared with rats that did not receive potassium. Potassium 0-9 kallikrein 1 Rattus norvegicus 80-84 23552867-4 2013 Potassium treatment increased the synthesis and excretion of tissue kallikrein (Klk1/rKLK1) accompanied by a significant reduction in blood pressure and renal fibrosis and with downregulation of renal transforming growth factor-beta (TGF-beta) mRNA and protein compared with rats that did not receive potassium. Potassium 0-9 kallikrein 1 Rattus norvegicus 85-90 23552867-4 2013 Potassium treatment increased the synthesis and excretion of tissue kallikrein (Klk1/rKLK1) accompanied by a significant reduction in blood pressure and renal fibrosis and with downregulation of renal transforming growth factor-beta (TGF-beta) mRNA and protein compared with rats that did not receive potassium. Potassium 301-310 kallikrein 1 Rattus norvegicus 80-84 23760924-13 2013 The ablation of Cx43 (n = 5) reduced the velocity of the potassium influx from 100 +- 11.2% in control mitochondria (n = 9) to 66.6 +- 5.5% (p < 0.05). Potassium 57-66 gap junction protein, alpha 1 Mus musculus 16-20 23760924-14 2013 Taken together, our data indicate that both pharmacological inhibition and genetic ablation of Cx43 reduce mitochondrial potassium influx. Potassium 121-130 gap junction protein, alpha 1 Mus musculus 95-99 23548411-7 2013 Moreover, renin-angiotensin system-blocking drugs may be harmful in such patients because they can functionally interfere with the effects of reactive rises in PRA that are triggered to prevent potentially dangerous falls in blood pressure, increases in plasma potassium, and falls in glomerular filtration rate. Potassium 261-270 renin Homo sapiens 10-15 23400760-2 2013 Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada Syndrome. Potassium 92-101 potassium voltage-gated channel subfamily D member 3 Homo sapiens 38-43 23400760-10 2013 This association of KV4.3 gain-of-function and early-onset lone AF further supports the hypothesis that increased potassium current enhances AF susceptibility. Potassium 114-123 potassium voltage-gated channel subfamily D member 3 Homo sapiens 20-25 23734178-6 2013 E633 is conserved among class I PI3 Ks, and its mutation in p110beta is also activating. Potassium 36-38 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Homo sapiens 60-68 23734226-9 2013 aegypti) is exacerbated when hemolymph potassium levels are elevated, suggesting that Kir channels are essential for maintenance of whole-animal potassium homeostasis. Potassium 39-48 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 86-89 23734226-9 2013 aegypti) is exacerbated when hemolymph potassium levels are elevated, suggesting that Kir channels are essential for maintenance of whole-animal potassium homeostasis. Potassium 145-154 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 86-89 23699522-0 2013 Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. Potassium 52-61 potassium voltage gated channel, Shab-related subfamily, member 2 Mus musculus 46-51 23730307-2 2013 Recently, the Kruppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating the transient outward potassium current (Ito), and that deficiency or excess of Klf15 increased the susceptibility of arrhythmias. Potassium 180-189 Kruppel like factor 15 Homo sapiens 14-36 23755094-16 2014 The dislocation of Kir4.1 will disturb the retinal potassium and water homeostasis, and osmotic generation of free radicals and inflammatory lipids may contribute to neurovascular injury. Potassium 51-60 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 19-25 23720627-1 2013 Two-pore domain K(+) (KCNK, K2P) channels underlie the "leak" (background) potassium conductance in many types of excitable cells. Potassium 75-84 keratin 76 Homo sapiens 28-31 23730307-2 2013 Recently, the Kruppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating the transient outward potassium current (Ito), and that deficiency or excess of Klf15 increased the susceptibility of arrhythmias. Potassium 180-189 Kruppel like factor 15 Homo sapiens 38-43 23730307-2 2013 Recently, the Kruppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating the transient outward potassium current (Ito), and that deficiency or excess of Klf15 increased the susceptibility of arrhythmias. Potassium 180-189 potassium voltage-gated channel interacting protein 2 Homo sapiens 107-113 27122708-1 2013 UNLABELLED: It is well-known that aldosterone plays an important role in reabsorption of sodium and fluid, and in potassium excretion in kidneys via epithelial mineralocorticoid receptor (MR) activation. Potassium 114-123 nuclear receptor subfamily 3 group C member 2 Homo sapiens 160-186 23530046-10 2013 Acidic medium triggered pH-dependent secretion of IL-1beta and activation of caspase-1 via a mechanism involving potassium efflux from the cells. Potassium 113-122 interleukin 1 beta Homo sapiens 50-58 23530046-10 2013 Acidic medium triggered pH-dependent secretion of IL-1beta and activation of caspase-1 via a mechanism involving potassium efflux from the cells. Potassium 113-122 caspase 1 Homo sapiens 77-86 27122708-1 2013 UNLABELLED: It is well-known that aldosterone plays an important role in reabsorption of sodium and fluid, and in potassium excretion in kidneys via epithelial mineralocorticoid receptor (MR) activation. Potassium 114-123 nuclear receptor subfamily 3 group C member 2 Homo sapiens 188-190 23538141-0 2013 Intracellular angiotensin II increases the total potassium current and the resting potential of arterial myocytes from vascular resistance vessels of the rat. Potassium 49-58 angiotensinogen Rattus norvegicus 14-28 23538141-2 2013 The influence of intracellular and extracellular administration of angiotensin II (Ang II; 10(-9) M) on total potassium current of arterial myocytes isolated from mesenteric arteries of Sprague Dawley rats was investigated. Potassium 110-119 angiotensinogen Rattus norvegicus 67-81 23538141-2 2013 The influence of intracellular and extracellular administration of angiotensin II (Ang II; 10(-9) M) on total potassium current of arterial myocytes isolated from mesenteric arteries of Sprague Dawley rats was investigated. Potassium 110-119 angiotensinogen Rattus norvegicus 83-89 23538141-5 2013 The presence of endogenous or internalized intracellular Ang II in vascular resistance vessels and its effect on potassium current and resting potential indicates that the peptide present inside the arterial myocytes plays an important role on the regulation of vascular tone and consequently on peripheral resistance, which is a determining factor in the regulation of arterial blood pressure. Potassium 113-122 angiotensinogen Rattus norvegicus 57-63 23427307-9 2013 The amplitude of the slow, inward astrocytic current due to potassium (K(+)) influx was also enhanced following activation of the endogenous mGluRs or the astrocyte-specific MrgA1 Gq GPCRs. Potassium 60-69 MAS-related GPR, member A1 Mus musculus 174-179 23532834-3 2013 The subject of this study was a search for vasopressin and vasotocin analogues with selective effects on renal water, sodium and potassium excretion. Potassium 129-138 arginine vasopressin Rattus norvegicus 43-54 23250862-0 2013 Potassium depolarization and raised calcium induces alpha-synuclein aggregates. Potassium 0-9 synuclein alpha Homo sapiens 52-67 23250862-3 2013 We hypothesized that depolarization with potassium resulting in raised Ca(2+) in a PD cell culture model will lead to the formation of alpha-synuclein protein aggregates and that the intracellular Ca(2+) buffer, BAPTA-AM, may suppress their formation. Potassium 41-50 synuclein alpha Homo sapiens 135-150 23123559-9 2013 Patients in cardiac arrest should receive uninterrupted CPR; with asystole, CPR may be terminated (or withheld) if a patient is lethally injured or completely frozen, the airway is blocked and duration of burial >35 min, serum potassium >12 mmol L(-1), risk to the rescuers is unacceptably high or a valid do-not-resuscitate order exists. Potassium 230-239 cytochrome p450 oxidoreductase Homo sapiens 76-79 23633076-4 2013 We compared the ratio of the rate of nonsynonymous (Ka) and synonymous (Ks) substitutions (Ka/Ks ratio) in the mitochondrial protein-coding gene sequences and found that atp8 had the highest Ka/Ks ratios in comparisons of A. franciscana with either A. tibetiana or A. urmiana and that atp6 had the highest Ka/Ks ratio between A. tibetiana and A. urmiana. Potassium 72-74 ATP synthase F0 subunit 8 Artemia franciscana 170-174 23633076-4 2013 We compared the ratio of the rate of nonsynonymous (Ka) and synonymous (Ks) substitutions (Ka/Ks ratio) in the mitochondrial protein-coding gene sequences and found that atp8 had the highest Ka/Ks ratios in comparisons of A. franciscana with either A. tibetiana or A. urmiana and that atp6 had the highest Ka/Ks ratio between A. tibetiana and A. urmiana. Potassium 94-96 ATP synthase F0 subunit 8 Artemia franciscana 170-174 23633076-4 2013 We compared the ratio of the rate of nonsynonymous (Ka) and synonymous (Ks) substitutions (Ka/Ks ratio) in the mitochondrial protein-coding gene sequences and found that atp8 had the highest Ka/Ks ratios in comparisons of A. franciscana with either A. tibetiana or A. urmiana and that atp6 had the highest Ka/Ks ratio between A. tibetiana and A. urmiana. Potassium 94-96 ATP synthase F0 subunit 8 Artemia franciscana 170-174 23633076-4 2013 We compared the ratio of the rate of nonsynonymous (Ka) and synonymous (Ks) substitutions (Ka/Ks ratio) in the mitochondrial protein-coding gene sequences and found that atp8 had the highest Ka/Ks ratios in comparisons of A. franciscana with either A. tibetiana or A. urmiana and that atp6 had the highest Ka/Ks ratio between A. tibetiana and A. urmiana. Potassium 94-96 ATP synthase F0 subunit 8 Artemia franciscana 170-174 23596459-5 2013 The p.P574S KV7.3 variant significantly reduced potassium current amplitude in Xenopus laevis oocytes when co-expressed with KV7.5 but not with KV7.2 or KV7.4. Potassium 48-57 potassium voltage-gated channel subfamily Q member 3 L homeolog Xenopus laevis 12-17 23596459-5 2013 The p.P574S KV7.3 variant significantly reduced potassium current amplitude in Xenopus laevis oocytes when co-expressed with KV7.5 but not with KV7.2 or KV7.4. Potassium 48-57 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 125-130 23426971-0 2013 Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current. Potassium 68-77 interleukin 10 Rattus norvegicus 0-14 23426971-0 2013 Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current. Potassium 68-77 angiotensinogen Rattus norvegicus 24-38 23550140-5 2013 This gene encodes a transporter required for high-affinity potassium transport in S. cerevisiae Data from reciprocal hemizygosity experiments with TRK1 deletion strains in K12 and BY backgrounds, as well as analysis of the deletion of this gene in the K12 strain, demonstrate that the K12 allele of TRK1 is responsible for ammonium toxicity resistance. Potassium 59-68 Trk1p Saccharomyces cerevisiae S288C 299-303 23550140-7 2013 These results demonstrate that the gene encoded by the K12 allele of TRK1 has a greater affinity for potassium than the standard allele of TRK1 found in Saccharomyces strains. Potassium 101-110 Trk1p Saccharomyces cerevisiae S288C 69-73 23593319-4 2013 Heterologous expression and co-immunoprecipitation shows that DPP6 co-expression with TASK-3 results in the formation of a protein complex that enhances resting membrane potassium conductance. Potassium 170-179 dipeptidyl peptidase like 6 Homo sapiens 62-66 23561701-1 2013 Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Potassium 171-180 ATPase, Na+/K+ transporting, alpha 2 polypeptide Mus musculus 27-33 23298862-8 2013 For methadone individual enantiomers and metabolism by CYP2B6.6 compared with CYP2B6.1, Vmax was diminished, Ks was greater and the in vitro intrinsic clearance was diminished 5- to 6-fold. Potassium 109-111 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 55-61 23298862-8 2013 For methadone individual enantiomers and metabolism by CYP2B6.6 compared with CYP2B6.1, Vmax was diminished, Ks was greater and the in vitro intrinsic clearance was diminished 5- to 6-fold. Potassium 109-111 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 78-84 23360744-6 2013 In this article, we provide a comprehensive overview of the genetic, cell biological, and pathophysiological causes of NDI, with emphasis on the congenital forms and the acquired forms arising from lithium and other drug therapies, acute and chronic renal failure, and disturbed levels of calcium and potassium. Potassium 301-310 arginine vasopressin receptor 2 Homo sapiens 119-122 23454581-0 2013 Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Potassium 65-74 phosphopantothenoylcysteine decarboxylase complex subunit SIS2 Saccharomyces cerevisiae S288C 36-40 23454581-0 2013 Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Potassium 65-74 phosphopantothenoylcysteine decarboxylase complex subunit VHS3 Saccharomyces cerevisiae S288C 41-45 23454581-5 2013 The evidence indicates that hyperactivation of Ppz1 would impair potassium transport through the Trk1/Trk2 transporters, thus resulting in a decrease in the intracellular pH and a subsequent increase in the levels of cAMP. Potassium 65-74 salt homeostasis regulator Saccharomyces cerevisiae S288C 47-51 23454581-5 2013 The evidence indicates that hyperactivation of Ppz1 would impair potassium transport through the Trk1/Trk2 transporters, thus resulting in a decrease in the intracellular pH and a subsequent increase in the levels of cAMP. Potassium 65-74 Trk1p Saccharomyces cerevisiae S288C 97-101 23454581-5 2013 The evidence indicates that hyperactivation of Ppz1 would impair potassium transport through the Trk1/Trk2 transporters, thus resulting in a decrease in the intracellular pH and a subsequent increase in the levels of cAMP. Potassium 65-74 Trk2p Saccharomyces cerevisiae S288C 102-106 23454581-8 2013 Cells lacking Trk1,2 display an invasive phenotype that is abolished by deletion of FLO8 or by increasing the potassium concentration in the medium. Potassium 110-119 Trk1p Saccharomyces cerevisiae S288C 14-18 22921586-6 2013 Additionally, efflux of intracellular potassium, lysosomal rupture, and oxygen radical (ROS) production are crucial for caspase-1 processing and IL-1beta secretion by TDB. Potassium 38-47 caspase 1 Mus musculus 120-129 22921586-6 2013 Additionally, efflux of intracellular potassium, lysosomal rupture, and oxygen radical (ROS) production are crucial for caspase-1 processing and IL-1beta secretion by TDB. Potassium 38-47 interleukin 1 beta Mus musculus 145-153 23232841-0 2013 An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. Potassium 25-34 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 13-19 23232841-11 2013 TREK-1 might balance potassium ion flow during hypertrophy and might be a potential drug target for heart protection. Potassium 21-30 potassium two pore domain channel subfamily K member 2 Rattus norvegicus 0-6 23443813-8 2013 In APA, CYP11B2 score adjusted for tumor volume was positively correlated with plasma aldosterone and negatively correlated with serum potassium. Potassium 135-144 glutamyl aminopeptidase Homo sapiens 3-6 23443813-8 2013 In APA, CYP11B2 score adjusted for tumor volume was positively correlated with plasma aldosterone and negatively correlated with serum potassium. Potassium 135-144 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 8-15 23376036-0 2013 Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle. Potassium 76-85 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 0-4 23373701-4 2013 Moreover, the D2R inhibitor raclopride blocked the increase of both GDNF and Zif268 expression following potassium-evoked dopamine release in SH-SY5Y cells. Potassium 105-114 glial cell derived neurotrophic factor Homo sapiens 68-72 23373701-4 2013 Moreover, the D2R inhibitor raclopride blocked the increase of both GDNF and Zif268 expression following potassium-evoked dopamine release in SH-SY5Y cells. Potassium 105-114 early growth response 1 Homo sapiens 77-83 23416519-5 2013 Functional in vitro studies of ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium. Potassium 109-118 ATPase Na+/K+ transporting subunit alpha 1 Homo sapiens 31-37 23548744-3 2013 In this study, we found that the REDUCED POTASSIUM DEPENDENCY3/HISTONE DEACETYLASE1-type histone deacetylase HDA15 directly interacted with PIF3 in vivo and in vitro. Potassium 41-50 histone deacetylase 1 Arabidopsis thaliana 63-83 23548744-3 2013 In this study, we found that the REDUCED POTASSIUM DEPENDENCY3/HISTONE DEACETYLASE1-type histone deacetylase HDA15 directly interacted with PIF3 in vivo and in vitro. Potassium 41-50 histone deacetylase 15 Arabidopsis thaliana 109-114 23548744-3 2013 In this study, we found that the REDUCED POTASSIUM DEPENDENCY3/HISTONE DEACETYLASE1-type histone deacetylase HDA15 directly interacted with PIF3 in vivo and in vitro. Potassium 41-50 phytochrome interacting factor 3 Arabidopsis thaliana 140-144 23531840-0 2013 5-HT1A receptor-mediated activation of outward potassium current by serotonin in mouse cultured spiral ganglion neurons. Potassium 47-56 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 0-15 23430254-0 2013 Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level. Potassium 95-104 F2R like trypsin receptor 1 Homo sapiens 6-37 23430254-7 2013 Conversely to angiotensin 2 receptor, PAR2 is involved in the regulation of sodium and potassium balance in the context of either stimulation or nonstimulation of the renin/angiotensin/aldosterone system. Potassium 87-96 F2R like trypsin receptor 1 Homo sapiens 38-42 23324064-1 2013 INTRODUCTION: Over the last two decades, the known functions of the mineralocorticoid receptor (MR) have expanded beyond regulation of sodium and potassium in epithelial cells to encompass physiological and pathophysiological effects in many tissues throughout the body. Potassium 146-155 nuclear receptor subfamily 3, group C, member 2 Mus musculus 68-94 23324064-1 2013 INTRODUCTION: Over the last two decades, the known functions of the mineralocorticoid receptor (MR) have expanded beyond regulation of sodium and potassium in epithelial cells to encompass physiological and pathophysiological effects in many tissues throughout the body. Potassium 146-155 nuclear receptor subfamily 3, group C, member 2 Mus musculus 96-98 23531840-7 2013 These results suggest that serotonin increases outward potassium currents in cultured spiral ganglion neurons through the activation of 5-HT1A receptor. Potassium 55-64 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 136-151 23610573-1 2013 OBJECTIVES: To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Potassium 95-104 beta-nerve growth factor Oryctolagus cuniculus 41-60 23171954-2 2013 MR antagonists are considered to be potassium-sparing diuretics that exert their effect by blocking MR in the kidney, and they are not the first choice for treating hypertension. Potassium 36-45 nuclear receptor subfamily 3 group C member 2 Homo sapiens 0-2 23610573-1 2013 OBJECTIVES: To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Potassium 95-104 beta-nerve growth factor Oryctolagus cuniculus 62-65 23610573-7 2013 CONCLUSIONS: Our results suggest that NGF treatment significantly prolongs APD in HMI cardiomyocytes and that a decrease in outward potassium currents and an increase of inward Ca(2+) current are likely the underlying mechanism of action. Potassium 132-141 beta-nerve growth factor Oryctolagus cuniculus 38-41 23439557-5 2013 Cesium induces expression of a high-affinity potassium transporter gene HAK5 and reduces potassium content in the plant body, suggesting a competitive nature of potassium and cesium uptake in plants. Potassium 45-54 high affinity K+ transporter 5 Arabidopsis thaliana 72-76 23255725-10 2013 Hypocretin excited MCH cells by activating a sodium-calcium exchanger and by reducing potassium currents; NPY reduced activity by increasing an inwardly rectifying potassium current. Potassium 86-95 hypocretin Mus musculus 0-10 23255725-10 2013 Hypocretin excited MCH cells by activating a sodium-calcium exchanger and by reducing potassium currents; NPY reduced activity by increasing an inwardly rectifying potassium current. Potassium 164-173 neuropeptide Y Mus musculus 106-109 23789440-1 2013 Ion-regulating renal function and influence of vasopressin and its analogues on the rate and selectiveness of the urinary potassium excretion were investigated after short-term parenteral and oral potassium loading. Potassium 122-131 arginine vasopressin Rattus norvegicus 47-58 23789440-5 2013 Desmopressin and 1-deamino-Arg4-vasotocin prevented rise of diuresis, natriuresis and magniuresis under these conditions; 1-deamino-Arg4-vasotocin and vasopressin stimulated urinary potassium excretion during first 30 min after loading. Potassium 182-191 arginine vasopressin Rattus norvegicus 151-162 23195681-0 2013 Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct. Potassium 55-64 WNK lysine deficient protein kinase 1 Mus musculus 16-20 23274715-9 2013 The results suggest that MWCNT increases the excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium current. Potassium 113-122 carbonic anhydrase 1 Rattus norvegicus 73-76 23241319-1 2013 KCNQ1 and hERG encode the voltage-gated potassium channel alpha-subunits of the cardiac repolarizing currents I(Ks) and I(Kr), respectively. Potassium 112-114 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 0-5 23241319-1 2013 KCNQ1 and hERG encode the voltage-gated potassium channel alpha-subunits of the cardiac repolarizing currents I(Ks) and I(Kr), respectively. Potassium 112-114 ETS transcription factor ERG Homo sapiens 10-14 23241319-4 2013 Biochemical assays indicated direct, protein-protein interactions between KCNQ1 and hERG may underlie the interplay between I(Ks) and I(Kr). Potassium 126-128 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 74-79 23241319-4 2013 Biochemical assays indicated direct, protein-protein interactions between KCNQ1 and hERG may underlie the interplay between I(Ks) and I(Kr). Potassium 126-128 ETS transcription factor ERG Homo sapiens 84-88 23318498-7 2013 The shortening of the action potential was related to an increase of potassium current which was measured in isolated ventricular myocytes before and after intracellular dialysis of renin (10(-9)M) using a voltage whole cell clamp configuration. Potassium 69-78 renin Rattus norvegicus 182-187 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Potassium 116-125 renin Rattus norvegicus 43-48 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Potassium 116-125 renin Rattus norvegicus 107-112 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. Potassium 16-25 renin Rattus norvegicus 68-73 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. Potassium 16-25 renin Rattus norvegicus 183-188 23318498-10 2013 Bis-1 which is a specific inhibitor of PKC, abolished the effect of intracellular renin on potassium current. Potassium 91-100 renin Rattus norvegicus 82-87 23318498-13 2013 The effect of renin on total potassium currents was inhibited by valsartan and by Bis-1. Potassium 29-38 renin Rattus norvegicus 14-19 22185904-8 2013 Half-blocking concentration of sodium and potassium currents were 43 muM and 557 muM; Hill coefficient was 1.1 and 0.9, respectively. Potassium 42-51 latexin Homo sapiens 69-72 22185904-8 2013 Half-blocking concentration of sodium and potassium currents were 43 muM and 557 muM; Hill coefficient was 1.1 and 0.9, respectively. Potassium 42-51 latexin Homo sapiens 81-84 23195681-6 2013 Compared with that in wild-type tubules, K(+) secretion was reduced in KS-WNK1 knockout CCD perfused at a low luminal fluid rate of ~1.5 nl/min. Potassium 71-73 WNK lysine deficient protein kinase 1 Mus musculus 74-78 23195681-7 2013 Na(+) reabsorption and the lumen-negative transepithelial potential difference were also lower in the KS-WNK1 knockout CCD compared with control CCD. Potassium 102-104 WNK lysine deficient protein kinase 1 Mus musculus 105-109 23195681-12 2013 In addition, KS-WNK1 plays a role in regulating Na(+) transport in the CCD. Potassium 13-15 WNK lysine deficient protein kinase 1 Mus musculus 16-20 23267025-6 2013 LL-37 activation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux. Potassium 75-84 cathelicidin antimicrobial peptide Homo sapiens 0-5 23267025-6 2013 LL-37 activation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux. Potassium 75-84 NLR family pyrin domain containing 3 Homo sapiens 24-29 23267025-6 2013 LL-37 activation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux. Potassium 75-84 purinergic receptor P2X 7 Homo sapiens 52-65 23396830-9 2013 We propose that the KUP6 subfamily transporters act as key factors in osmotic adjustment by balancing potassium homeostasis in cell growth and drought stress responses. Potassium 102-111 K+ uptake permease 6 Arabidopsis thaliana 20-24 23142267-9 2013 Moreover, we found a significant increase in the S100B secretion basal levels with the increasing of animal age and the incubation with high levels of potassium resulted in a decrease of S100B secretion in 30 and 90-day old rats. Potassium 151-160 S100 calcium binding protein B Rattus norvegicus 49-54 23142267-9 2013 Moreover, we found a significant increase in the S100B secretion basal levels with the increasing of animal age and the incubation with high levels of potassium resulted in a decrease of S100B secretion in 30 and 90-day old rats. Potassium 151-160 S100 calcium binding protein B Rattus norvegicus 187-192 23135699-3 2013 Switching from SMB to SMA MHC protein expression decreased the rate of the force transient and increased the sustained tonic force in SMB((-/-)) ileum and antrum with high potassium (KPSS) but not with carbachol (CCh) stimulation. Potassium 172-181 immunoglobulin mu binding protein 2 Mus musculus 22-25 23240720-0 2013 HIV-1 Vpu protein mediates the transport of potassium in Saccharomyces cerevisiae. Potassium 44-53 Vpu Human immunodeficiency virus 1 6-9 23224874-2 2013 Na(+)/Ca(2+) exchangers, NCX and NCKX, play a critical role in the transport of one [Ca(2+)](i) and potassium ion across the cell membrane in exchange for four extracellular sodium ions [Na(+)](e). Potassium 100-109 T cell leukemia homeobox 2 Homo sapiens 25-28 23224874-2 2013 Na(+)/Ca(2+) exchangers, NCX and NCKX, play a critical role in the transport of one [Ca(2+)](i) and potassium ion across the cell membrane in exchange for four extracellular sodium ions [Na(+)](e). Potassium 100-109 solute carrier family 24 member 1 Homo sapiens 33-37 23224874-3 2013 Mammalian plasma membrane Na(+)/Ca(2+) exchange proteins are divided into two families: one in which Ca(2+) flux is dependent only on sodium (NCX1-3) and another in which Ca(2+) flux is also dependent on potassium (NCKX1-4). Potassium 204-213 solute carrier family 8 member A1 Homo sapiens 142-148 23037322-7 2013 HDL-C and Apo A-I were positively correlated with Ks (r = 0.52, P < 0.00001 and r = 0.44, P < 0.00001, respectively) and inversely with t50% (r = -0.44, P < 0.00001 and r = -0.35, P = 0.00003, respectively). Potassium 50-52 apolipoprotein A1 Homo sapiens 10-17 23037322-9 2013 Ks and t50% were associated with Lp(a) (r = -0.42, P < 0.00001 and r = 0.42, P < 0.00001, respectively) and fibrinogen (r = -0.31, P = 0.00024 and r = 0.39, P < 0.00001, respectively). Potassium 0-2 lipoprotein(a) Homo sapiens 33-38 23037322-9 2013 Ks and t50% were associated with Lp(a) (r = -0.42, P < 0.00001 and r = 0.42, P < 0.00001, respectively) and fibrinogen (r = -0.31, P = 0.00024 and r = 0.39, P < 0.00001, respectively). Potassium 0-2 fibrinogen beta chain Homo sapiens 114-124 22193336-2 2013 AQP4 has been hypothesized to modulate water and potassium fluxes associated with neuronal activity in pathophysiological states. Potassium 49-58 aquaporin 4 Mus musculus 0-4 24429825-0 2013 Co-regulated pendrin and aquaporin 5 expression and trafficking in Type-B intercalated cells under potassium depletion. Potassium 99-108 solute carrier family 26, member 4 Mus musculus 13-20 24429825-0 2013 Co-regulated pendrin and aquaporin 5 expression and trafficking in Type-B intercalated cells under potassium depletion. Potassium 99-108 aquaporin 5 Mus musculus 25-36 23221912-0 2013 Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs. Potassium 61-70 potassium voltage-gated channel subfamily H member 2 Homo sapiens 94-98 23221912-4 2013 Extracellular potassium influences HERG channel inactivation and can alter block of HERG by some drugs. Potassium 14-23 potassium voltage-gated channel subfamily H member 2 Homo sapiens 35-39 23221912-4 2013 Extracellular potassium influences HERG channel inactivation and can alter block of HERG by some drugs. Potassium 14-23 potassium voltage-gated channel subfamily H member 2 Homo sapiens 84-88 23221912-7 2013 We also show that bepridil block of the HERG mutant D540K, a mutant channel that is unable to trap drugs, is dependent on extracellular potassium, correlates with the permeant ion, and is independent of HERG inactivation. Potassium 136-145 potassium voltage-gated channel subfamily H member 2 Homo sapiens 40-44 23221912-8 2013 These results suggest that the lack of extracellular potassium dependency of block of HERG by some drugs may in part be related to the ability of these drugs to be trapped inside the channel after the channel closes. Potassium 53-62 potassium voltage-gated channel subfamily H member 2 Homo sapiens 86-90 23059770-0 2013 Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study. Potassium 101-110 WNK lysine deficient protein kinase 1 Homo sapiens 45-49 23059770-2 2013 The aim of this study was to identify the effect of common WNK1 variants on the shift of BP during strict dietary interventions of salt or potassium intake. Potassium 139-148 WNK lysine deficient protein kinase 1 Homo sapiens 59-63 23059770-7 2013 CONCLUSIONS: The WNK1 gene might be mechanistically involved in the variation in BP response to dietary sodium and potassium intake among individuals, and might contribute to the variation of this complex phenotype. Potassium 115-124 WNK lysine deficient protein kinase 1 Homo sapiens 17-21 23165113-0 2013 Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron. Potassium 56-65 angiotensinogen Homo sapiens 11-25 23165113-1 2013 PURPOSE OF REVIEW: The aim is to review the recently reported effects of angiotensin II (Ang II) on sodium and potassium transport in the aldosterone-sensitive distal nephron, including the signaling pathways between receptor and transporter, and the (patho)physiological implications of these findings. Potassium 111-120 angiotensinogen Homo sapiens 73-87 23165113-1 2013 PURPOSE OF REVIEW: The aim is to review the recently reported effects of angiotensin II (Ang II) on sodium and potassium transport in the aldosterone-sensitive distal nephron, including the signaling pathways between receptor and transporter, and the (patho)physiological implications of these findings. Potassium 111-120 angiotensinogen Homo sapiens 89-95 23165113-8 2013 SUMMARY: The effects of Ang II on NCC, ENaC, and ROMK help explain the renal response to hypovolemia which is to conserve both sodium and potassium. Potassium 138-147 angiotensinogen Homo sapiens 24-30 23106642-7 2013 Apelin (1 nM) increased sodium currents, ultra-rapid potassium currents and the reverse mode of sodium-calcium exchanger currents, but decreased late sodium currents and L-type calcium currents and did not change transient outward currents or inward rectifier potassium currents in LA myocytes. Potassium 53-62 APLN Oryctolagus cuniculus 0-6 24069049-14 2013 GA significantly inhibited the potassium currents in a dose- and voltage-dependent manner, suggesting that it exerts its antiarrhythmic action through the prolongation of APD and ERP owing to the inhibition of I K (I Kr, I Ks) and HERG K(+) channel. Potassium 31-40 potassium voltage-gated channel subfamily H member 2 Homo sapiens 231-235 22999866-5 2013 Patch-clamp studies displayed outward potassium currents, probably carried through Kir6.1 channels. Potassium 38-47 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 83-89 23554830-0 2013 Saikosaponin a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons. Potassium 47-56 carbonic anhydrase 1 Rattus norvegicus 84-87 23165302-7 2013 Finally, a role of angiotensin II in sodium and potassium handling in the distal nephron has been identified. Potassium 48-57 angiotensinogen Homo sapiens 19-33 23382593-4 2013 Based on the circadian expression of KChIP2, we can accurately predict the circadian rhythm in cardiac electrical activity and suggest the transient outward potassium currents as the key current for circadian rhythmicity. Potassium 157-166 potassium voltage-gated channel interacting protein 2 Homo sapiens 37-43 23292580-9 2013 Change in serum potassium among patients with hyperkalemia was 4.0 +- 0.5 mEq/L before TxK and 5.3 +- 0.7 mEq/L after TxK. Potassium 16-25 TXK tyrosine kinase Homo sapiens 87-90 23292580-9 2013 Change in serum potassium among patients with hyperkalemia was 4.0 +- 0.5 mEq/L before TxK and 5.3 +- 0.7 mEq/L after TxK. Potassium 16-25 TXK tyrosine kinase Homo sapiens 118-121 23099443-5 2013 The hKv1.3-E314 antibody that we had generated as a specific hKv1.3 blocker inhibited outward delayed rectifier potassium currents, whereas the hKv1.5-E313 antibody that we had generated as a specific hKv1.5 blocker failed. Potassium 112-121 potassium voltage-gated channel subfamily A member 3 Homo sapiens 4-10 23099443-5 2013 The hKv1.3-E314 antibody that we had generated as a specific hKv1.3 blocker inhibited outward delayed rectifier potassium currents, whereas the hKv1.5-E313 antibody that we had generated as a specific hKv1.5 blocker failed. Potassium 112-121 potassium voltage-gated channel subfamily A member 3 Homo sapiens 61-67 23220438-1 2012 We report a unique case of diabetic ketoacidosis in which a relatively low potassium level on admission was associated with consequent life-threatening and refractory arrhythmia secondary to inappropriate use of intravenous insulin and bicarbonate therapy. Potassium 75-84 insulin Homo sapiens 224-231 23109687-0 2013 A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis. Potassium 146-155 SNF1-related protein kinase 2.2 Arabidopsis thaliana 2-16 23109687-0 2013 A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis. Potassium 178-187 SNF1-related protein kinase 2.2 Arabidopsis thaliana 2-16 23577126-8 2013 We found that a significant portion of resting membrane potassium permeability in wild-type sperm was contributed by SLO3 K(+) channels. Potassium 56-65 potassium channel, subfamily U, member 1 Mus musculus 117-121 23633957-10 2013 HCV uptake concomitantly induces a potassium efflux that activates the NLRP3 inflammasome for IL-1beta processing and secretion. Potassium 35-44 NLR family pyrin domain containing 3 Homo sapiens 71-76 23633957-10 2013 HCV uptake concomitantly induces a potassium efflux that activates the NLRP3 inflammasome for IL-1beta processing and secretion. Potassium 35-44 interleukin 1 beta Homo sapiens 94-102 23109340-0 2012 The structure of Sec12 implicates potassium ion coordination in Sar1 activation. Potassium 34-43 Sar family guanine nucleotide exchange factor SEC12 Saccharomyces cerevisiae S288C 17-22 23109340-0 2012 The structure of Sec12 implicates potassium ion coordination in Sar1 activation. Potassium 34-43 Arf family GTPase SAR1 Saccharomyces cerevisiae S288C 64-68 23084712-10 2012 Potassium intake was positively correlated with Cornell VDP (r = 0.119, p < 0.05), CAIx (r = 0.178, p < 0.01) and PAIx (r = 0.202, p < 0.01). Potassium 0-9 carbonic anhydrase 9 Homo sapiens 86-90 22948499-6 2012 In contrast to S. cerevisiae, Z. rouxii cells without the TRK1 gene contained less potassium than the control cells and their plasma membrane was significantly hyperpolarized compared with those of the parental strain when grown in the presence of 100 mM KCl. Potassium 83-92 Trk1p Saccharomyces cerevisiae S288C 58-62 22918120-4 2012 Genetic inactivation of one of the genes identified by our strategy, dickkopf-3 (Dkk3), whose expression is increased by calcium influx into adrenocortical cells, in the Kcnk3 null background results in the extension of the low-renin, potassium-rich diet insensitive hyperaldosteronemic phenotype to the male sex. Potassium 235-244 dickkopf WNT signaling pathway inhibitor 3 Homo sapiens 69-79 23000022-8 2012 Co-expression of G325R and WT KCNQ1 with KCNE1 shifted the voltage-dependence of I(Ks) activation by 12.0mV, indicating co-assembly of mutant and WT subunits. Potassium 83-85 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 30-35 23000022-8 2012 Co-expression of G325R and WT KCNQ1 with KCNE1 shifted the voltage-dependence of I(Ks) activation by 12.0mV, indicating co-assembly of mutant and WT subunits. Potassium 83-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 41-46 23232097-4 2012 Plants lacking UBP16 were hypersensitive to salt stress and accumulated more sodium and less potassium. Potassium 93-102 ubiquitin-specific protease 16 Arabidopsis thaliana 15-20 23102642-6 2012 Laboratory studies revealed a low serum potassium level at 2.8 mmol/L associated with high urinary potassium excretion (84 mmol/24h) and a very high aldosterone/renin ratio (>462). Potassium 40-49 renin Homo sapiens 161-166 23197740-7 2012 Intracellular recordings from ex vivo dorsal root ganglion preparations revealed that Kv9.1 knock-down was linked to lowered firing thresholds and increased firing rates under physiologically relevant conditions of extracellular potassium accumulation during prolonged activity. Potassium 229-238 potassium voltage-gated channel, modifier subfamily S, member 1 Rattus norvegicus 86-91 22918120-4 2012 Genetic inactivation of one of the genes identified by our strategy, dickkopf-3 (Dkk3), whose expression is increased by calcium influx into adrenocortical cells, in the Kcnk3 null background results in the extension of the low-renin, potassium-rich diet insensitive hyperaldosteronemic phenotype to the male sex. Potassium 235-244 dickkopf WNT signaling pathway inhibitor 3 Homo sapiens 81-85 22989884-3 2012 Once activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters. Potassium 78-87 WNK lysine deficient protein kinase 1 Homo sapiens 18-22 22989884-3 2012 Once activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters. Potassium 78-87 oxidative stress responsive kinase 1 Homo sapiens 24-28 22989884-3 2012 Once activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters. Potassium 78-87 serine/threonine kinase 39 Homo sapiens 33-37 22989884-3 2012 Once activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters. Potassium 78-87 solute carrier family 12 member 2 Homo sapiens 119-124 22989884-3 2012 Once activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters. Potassium 78-87 solute carrier family 12 member 1 Homo sapiens 129-134 22156575-6 2012 We speculate that KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells. Potassium 159-168 potassium channel tetramerization domain containing 8 Homo sapiens 18-23 22736459-1 2012 Spinocerebellar ataxia type 13 (SCA13) is an autosomal dominant disease caused by mutations in the Kv3.3 voltage-gated potassium (K(+)) channel. Potassium 119-128 potassium voltage-gated channel subfamily C member 3 Homo sapiens 99-104 23039231-4 2012 Lack of potassium drastically alters sulfur metabolism (mainly Met and Cys metabolism), triggers an oxidative stress response and activates the retrograde pathway, possibly due to the ammonium accumulation that occurs through the Trk1 potassium transporter. Potassium 8-17 Trk1p Saccharomyces cerevisiae S288C 230-234 23039231-6 2012 Only specific subsets of these changes were observed in a strain deleted for the TRK1 and TRK2 genes growing in the presence of sufficient potassium (50 mM). Potassium 139-148 Trk1p Saccharomyces cerevisiae S288C 81-85 23039231-6 2012 Only specific subsets of these changes were observed in a strain deleted for the TRK1 and TRK2 genes growing in the presence of sufficient potassium (50 mM). Potassium 139-148 Trk2p Saccharomyces cerevisiae S288C 90-94 22997256-6 2012 Activation of NLRP3 required phagocytosis of uromodulin particles into lysosomes, cathepsin leakage, oxidative stress, and potassium efflux from the cell. Potassium 123-132 NLR family pyrin domain containing 3 Homo sapiens 14-19 23063532-0 2012 Mechanical stretch reduces the effect of angiotensin II on potassium current in cardiac ventricular cells of adult Sprague Dawley rats. Potassium 59-68 angiotensinogen Rattus norvegicus 41-55 23063532-2 2012 The influence of mechanical stretch on the effect of angiotensin II (Ang II) on potassium current was investigated on cardiomyocytes isolated from the left ventricle of adult Sprague Dawley rats. Potassium 80-89 angiotensinogen Rattus norvegicus 53-67 23063532-2 2012 The influence of mechanical stretch on the effect of angiotensin II (Ang II) on potassium current was investigated on cardiomyocytes isolated from the left ventricle of adult Sprague Dawley rats. Potassium 80-89 angiotensinogen Rattus norvegicus 69-75 23063532-5 2012 In conclusion, the mechanical stretch of cardiomyocytes increases the potassium currents, an effect greatly dependent on the mechanical activation of AT1 receptors independently of Ang II. Potassium 70-79 angiotensin II receptor, type 1a Rattus norvegicus 150-153 23063532-6 2012 In addition, the increment of potassium currents caused by Ang II was greatly reduced by mechanical stretch, an effect abolished by protein kinase C inhibition. Potassium 30-39 angiotensinogen Rattus norvegicus 59-65 22976302-7 2012 In the present study, GABA and SDF-1 are shown to exert opposite effects on the speed of cell movement by activating depolarizing or hyperpolarizing signaling pathways, GABA via changes in chloride and SDF-1 via changes in potassium. Potassium 223-232 C-X-C motif chemokine ligand 12 Homo sapiens 31-36 23373225-3 2012 RESULT: On the 7th day, the neuron-like cells derived from ginsenoside Rg1 (20 mg x L(-1))-induced NSCs show: (1) The resting membrane potential: (-45.70 +/- 2.63) mV, the membrane capacitance: (26.89 +/- 1.91) pF, the membrane input impedance: (877.51 +/- 20.44) MH (P < 0.05 compared with the control group, respectively); (2) The detection rate of inward sodium current which is rapidly activated and inactivated in voltage-dependence was 50%, and its average peak value was (711.48 +/- 158.03) pA (P < 0.05 compared with the control group); (3) The outward potassium currents were composed of rapidly activated and inactivated transient outward potassium current and delayed rectifier outward potassium current, and its average peak value was (1 070.42 +/- 177.18) pA (P < 0.05 compared with the control group). Potassium 567-576 protein phosphatase 1 regulatory subunit 3A Homo sapiens 71-74 23373225-3 2012 RESULT: On the 7th day, the neuron-like cells derived from ginsenoside Rg1 (20 mg x L(-1))-induced NSCs show: (1) The resting membrane potential: (-45.70 +/- 2.63) mV, the membrane capacitance: (26.89 +/- 1.91) pF, the membrane input impedance: (877.51 +/- 20.44) MH (P < 0.05 compared with the control group, respectively); (2) The detection rate of inward sodium current which is rapidly activated and inactivated in voltage-dependence was 50%, and its average peak value was (711.48 +/- 158.03) pA (P < 0.05 compared with the control group); (3) The outward potassium currents were composed of rapidly activated and inactivated transient outward potassium current and delayed rectifier outward potassium current, and its average peak value was (1 070.42 +/- 177.18) pA (P < 0.05 compared with the control group). Potassium 655-664 protein phosphatase 1 regulatory subunit 3A Homo sapiens 71-74 23373225-3 2012 RESULT: On the 7th day, the neuron-like cells derived from ginsenoside Rg1 (20 mg x L(-1))-induced NSCs show: (1) The resting membrane potential: (-45.70 +/- 2.63) mV, the membrane capacitance: (26.89 +/- 1.91) pF, the membrane input impedance: (877.51 +/- 20.44) MH (P < 0.05 compared with the control group, respectively); (2) The detection rate of inward sodium current which is rapidly activated and inactivated in voltage-dependence was 50%, and its average peak value was (711.48 +/- 158.03) pA (P < 0.05 compared with the control group); (3) The outward potassium currents were composed of rapidly activated and inactivated transient outward potassium current and delayed rectifier outward potassium current, and its average peak value was (1 070.42 +/- 177.18) pA (P < 0.05 compared with the control group). Potassium 655-664 protein phosphatase 1 regulatory subunit 3A Homo sapiens 71-74 23115170-6 2012 The properties of this current matched that of the native Slack potassium current, which was identified using an siRNA approach. Potassium 64-73 potassium sodium-activated channel subfamily T member 1 Homo sapiens 58-63 23090492-1 2012 Inwardly rectifying potassium channels (Kir) are a special subset of potassium selective ion channels which pass potassium more easily into rather than out of the cell. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 40-43 22989185-1 2012 The human ether-a-go-go related gene 1 (hERG1) K ion channel is a key element for the rapid component of the delayed rectified potassium current in cardiac myocytes. Potassium 127-136 potassium voltage-gated channel subfamily H member 2 Homo sapiens 40-45 23082064-7 2012 At the cell level, ginsenoside Rb1 increased outward potassium currents, and IK(V) was enhanced from 1137.71 +- 171.62 pA to 1449.73 +- 162.39 pA by 50 mumol/L Rb1 at +60 mV (n = 6, P < 0.05). Potassium 53-62 RB transcriptional corepressor 1 Mus musculus 31-34 22908235-1 2012 The co-assembly of KCNQ1 with KCNE1 produces I(KS), a K(+) current, crucial for the repolarization of the cardiac action potential. Potassium 47-49 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 19-24 22908235-1 2012 The co-assembly of KCNQ1 with KCNE1 produces I(KS), a K(+) current, crucial for the repolarization of the cardiac action potential. Potassium 47-49 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 30-35 23035098-7 2012 In stark contrast, NRG1 had minor effects on whole-cell potassium currents. Potassium 56-65 neuregulin 1 Rattus norvegicus 19-23 22728096-4 2012 The IL-1beta release depended on potassium efflux but was independent of reactive oxygen generation of bovine monocytes. Potassium 33-42 interleukin 1 beta Bos taurus 4-12 22917023-9 2012 A linear calibration curve for the coulometric cell with valinomycin potassium-selective membrane was obtained in the range of 100 nM to 10 muM potassium in the presence of a 10 muM sodium background. Potassium 69-78 latexin Homo sapiens 140-143 22481627-3 2012 Elevated extracellular potassium to levels occurring around hyperactive neurons affects both gap junction and pannexin1 channels. Potassium 23-32 pannexin 1 Homo sapiens 110-119 22481627-6 2012 Pannexin1 can be activated by elevations in extracellular potassium through a mechanism that is quite different. Potassium 58-67 pannexin 1 Homo sapiens 0-9 21404100-4 2012 The finding of abnormal potassium levels (low or high) in the presence of suppressed renin secretion, and metabolic alkalosis or acidosis should prompt consideration of these familial diseases. Potassium 24-33 renin Homo sapiens 85-90 22713745-3 2012 In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood. Potassium 87-96 cpe Clostridium perfringens 15-18 22917023-9 2012 A linear calibration curve for the coulometric cell with valinomycin potassium-selective membrane was obtained in the range of 100 nM to 10 muM potassium in the presence of a 10 muM sodium background. Potassium 69-78 latexin Homo sapiens 178-181 22917023-10 2012 In the presence of a higher (100 muM) concentration of sodium, a reliable detection of 1-100 muM of potassium was achieved. Potassium 100-109 latexin Homo sapiens 33-36 22917023-10 2012 In the presence of a higher (100 muM) concentration of sodium, a reliable detection of 1-100 muM of potassium was achieved. Potassium 100-109 latexin Homo sapiens 93-96 22508963-13 2012 In conclusion, increased I(Ks) due to the KCNQ1 S140G mutation increases atrial susceptibility to arrhythmia due to increased tissue vulnerability, shortened ERP and altered atrial conduction velocity, which, in combination, facilitate initiation and maintenance of re-entrant excitation waves. Potassium 27-29 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 42-47 22771251-7 2012 The activity of the antioxidative enzymes SOD, peroxidase and APX in potassium deprivation significantly increased, whereas CAT and DHAR activity was significantly depressed in the potassium starvation treatment compared to controls. Potassium 69-78 iron superoxide dismutase Solanum lycopersicum 42-45 22771251-7 2012 The activity of the antioxidative enzymes SOD, peroxidase and APX in potassium deprivation significantly increased, whereas CAT and DHAR activity was significantly depressed in the potassium starvation treatment compared to controls. Potassium 69-78 peroxidase Solanum lycopersicum 47-57 22771251-7 2012 The activity of the antioxidative enzymes SOD, peroxidase and APX in potassium deprivation significantly increased, whereas CAT and DHAR activity was significantly depressed in the potassium starvation treatment compared to controls. Potassium 69-78 cytosolic ascorbate peroxidase 2 Solanum lycopersicum 62-65 22771251-7 2012 The activity of the antioxidative enzymes SOD, peroxidase and APX in potassium deprivation significantly increased, whereas CAT and DHAR activity was significantly depressed in the potassium starvation treatment compared to controls. Potassium 181-190 catalase isozyme 1 Solanum lycopersicum 124-127 22771251-7 2012 The activity of the antioxidative enzymes SOD, peroxidase and APX in potassium deprivation significantly increased, whereas CAT and DHAR activity was significantly depressed in the potassium starvation treatment compared to controls. Potassium 181-190 dehydroascorbate reductase Solanum lycopersicum 132-136 22931498-1 2012 Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. Potassium 6-15 BOC cell adhesion associated, oncogene regulated Homo sapiens 16-19 22840709-2 2012 In the presence of potassium ion, AS1411 folded to G-quadruplex structure, binded fluorescent ligand (PPIX) with fluorescent enhancement, and targeted the nucleolin overexpressed by cancer cells. Potassium 19-28 nucleolin Homo sapiens 155-164 22914841-1 2012 OBJECTIVE: To electrophysiologically characterize the Na(v)1.4 mutant N440K found in a Korean family with a syndrome combining symptoms of paramyotonia congenita, hyperkalemic periodic paralysis, and potassium-aggravated myotonia. Potassium 200-209 immunoglobulin lambda variable 2-14 Homo sapiens 54-62 22791335-3 2012 The role of KS-WNK1 in other nephron segments is less clear. Potassium 12-14 WNK lysine deficient protein kinase 1 Mus musculus 15-19 22791335-4 2012 Here, we measured the expression of KS-WNK1 transcript in microdissected renal tubules and found that KS-WNK1 was most abundant in the DCT, followed by cortical thick ascending limb (cTAL), connecting tubule, and cortical collecting duct. Potassium 36-38 WNK lysine deficient protein kinase 1 Mus musculus 39-43 22791335-4 2012 Here, we measured the expression of KS-WNK1 transcript in microdissected renal tubules and found that KS-WNK1 was most abundant in the DCT, followed by cortical thick ascending limb (cTAL), connecting tubule, and cortical collecting duct. Potassium 36-38 WNK lysine deficient protein kinase 1 Mus musculus 105-109 22791335-5 2012 A high K(+) diet enhanced the expression of KS-WNK1 in the DCT and cTAL, selectively. Potassium 44-46 WNK lysine deficient protein kinase 1 Mus musculus 47-51 22791335-8 2012 Furosemide-sensitive Na(+) reabsorption in cTAL was higher in KS-WNK1-knockout (KO) mice than in wild-type. Potassium 62-64 WNK lysine deficient protein kinase 1 Mus musculus 65-69 22820370-9 2012 SUMMARY: Modulation of WNK4 activity by AngII underlies the effects of AngII on NCC activity and this is probably important for the stimulation of renal sodium retention, as well as for the prevention of potassium loss, during hypovolemia. Potassium 204-213 WNK lysine deficient protein kinase 4 Homo sapiens 23-27 22791335-9 2012 A high-K(+) diet inhibited Na(+) reabsorption in cTAL from wild-type mice, but the inhibition was eliminated in KS-WNK1-KO mice. Potassium 112-114 WNK lysine deficient protein kinase 1 Mus musculus 115-119 22791335-13 2012 Thus KS-WNK1 inhibits Na(+) reabsorption in cTAL and mediates the inhibition of Na(+) reabsorption in the segment by a high-K diet. Potassium 5-7 WNK lysine deficient protein kinase 1 Mus musculus 8-12 23020479-5 2012 A Hodgkin-Huxley-style cardiac ionic model captured the different types of complex dynamics following blockage of the hERG mediated potassium current. Potassium 132-141 ETS transcription factor ERG Homo sapiens 118-122 22820370-9 2012 SUMMARY: Modulation of WNK4 activity by AngII underlies the effects of AngII on NCC activity and this is probably important for the stimulation of renal sodium retention, as well as for the prevention of potassium loss, during hypovolemia. Potassium 204-213 angiotensinogen Homo sapiens 40-45 22820370-9 2012 SUMMARY: Modulation of WNK4 activity by AngII underlies the effects of AngII on NCC activity and this is probably important for the stimulation of renal sodium retention, as well as for the prevention of potassium loss, during hypovolemia. Potassium 204-213 angiotensinogen Homo sapiens 71-76 22406475-0 2012 The Arabidopsis AP2/ERF transcription factor RAP2.11 modulates plant response to low-potassium conditions. Potassium 85-94 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 16-19 22828404-2 2012 Recently we showed that administration of a selective GPR30 agonist (G-1) to ovariectomized rats enhanced acquisition of a delayed matching-to-position (DMP) T-maze task and increased potassium-stimulated acetylcholine release in the hippocampus, similar to estradiol (E2) (Hammond et al., 2009). Potassium 184-193 G protein-coupled estrogen receptor 1 Rattus norvegicus 54-59 22575762-5 2012 Cells cotransduced with Tbx5, Mef2c, Myocd expressed cardiac contractile proteins, had cardiac-like potassium and sodium currents and action potentials could be elicited. Potassium 100-109 T-box 5 Mus musculus 24-28 22575762-5 2012 Cells cotransduced with Tbx5, Mef2c, Myocd expressed cardiac contractile proteins, had cardiac-like potassium and sodium currents and action potentials could be elicited. Potassium 100-109 myocyte enhancer factor 2C Mus musculus 30-35 22575762-5 2012 Cells cotransduced with Tbx5, Mef2c, Myocd expressed cardiac contractile proteins, had cardiac-like potassium and sodium currents and action potentials could be elicited. Potassium 100-109 myocardin Mus musculus 37-42 22969707-2 2012 Further upstream, in the lateral superior olive (LSO), absence of low-threshold potassium currents in Kcna1(-/-) mice interfered with response onset timing and restricted IID-sensitivity to the hemifield of the excitatory ear. Potassium 80-89 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 102-107 22778270-2 2012 In heart, Yotiao directly associates with the slow outward potassium ion current (I(Ks)) and recruits both PKA and PP1 to regulate I(Ks) phosphorylation and gating. Potassium 59-68 A-kinase anchoring protein 9 Homo sapiens 10-16 22778270-2 2012 In heart, Yotiao directly associates with the slow outward potassium ion current (I(Ks)) and recruits both PKA and PP1 to regulate I(Ks) phosphorylation and gating. Potassium 84-86 A-kinase anchoring protein 9 Homo sapiens 10-16 22778270-2 2012 In heart, Yotiao directly associates with the slow outward potassium ion current (I(Ks)) and recruits both PKA and PP1 to regulate I(Ks) phosphorylation and gating. Potassium 133-135 A-kinase anchoring protein 9 Homo sapiens 10-16 22778270-2 2012 In heart, Yotiao directly associates with the slow outward potassium ion current (I(Ks)) and recruits both PKA and PP1 to regulate I(Ks) phosphorylation and gating. Potassium 133-135 protein phosphatase 1 catalytic subunit gamma Mus musculus 115-118 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 31-33 A-kinase anchoring protein 9 Homo sapiens 35-41 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 31-33 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 123-128 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 111-113 A-kinase anchoring protein 9 Homo sapiens 35-41 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 111-113 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 123-128 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 111-113 A-kinase anchoring protein 9 Homo sapiens 35-41 22778270-3 2012 Human mutations that disrupt I(Ks)-Yotiao interaction result in reduced PKA-dependent phosphorylation of the I(Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I(Ks), which can give rise to long-QT syndrome. Potassium 111-113 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 123-128 22778270-9 2012 Furthermore, the endogenous I(Ks)-Yotiao complex from guinea pig also contained AC9. Potassium 30-32 A-kinase anchoring protein 9 Homo sapiens 34-40 22778270-9 2012 Furthermore, the endogenous I(Ks)-Yotiao complex from guinea pig also contained AC9. Potassium 30-32 adenylate cyclase 9 Mus musculus 80-83 22778270-11 2012 Thus, in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. Potassium 72-74 A-kinase anchoring protein 9 Homo sapiens 16-22 22406475-2 2012 The transcription factor RAP2.11 was identified as a component in the response to low potassium through regulation of the high-affinity K(+) uptake transporter AtHAK5 and other components of the low-potassium signal transduction pathway. Potassium 86-95 high affinity K+ transporter 5 Arabidopsis thaliana 160-166 22406475-2 2012 The transcription factor RAP2.11 was identified as a component in the response to low potassium through regulation of the high-affinity K(+) uptake transporter AtHAK5 and other components of the low-potassium signal transduction pathway. Potassium 199-208 high affinity K+ transporter 5 Arabidopsis thaliana 160-166 22406475-3 2012 RAP2.11 was identified through the activation tagging of Arabidopsis lines that contained a luciferase marker driven by the AtHAK5 promoter that is normally only induced by low potassium. Potassium 177-186 high affinity K+ transporter 5 Arabidopsis thaliana 124-130 22668657-7 2012 Magnesium deficiency by interfering with ATPase functions causes increased intracellular calcium and sodium and decreases intracellular potassium concentration. Potassium 136-145 dynein axonemal heavy chain 8 Homo sapiens 41-47 22799266-4 2012 This finding supports a model according to which the ACP-bound polyketide intermediate is transferred back to the KS domain on the opposite PKS strand. Potassium 114-116 CPAT1 Homo sapiens 53-56 22745159-2 2012 Among the 12 identified genes causal to heritable LQTS, ~90% of affected individuals harbor mutations in either KCNQ1 or human ether-a-go-go related genes (hERG), which encode two repolarizing potassium currents known as I(Ks) and I(Kr). Potassium 193-202 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 112-117 22212640-2 2012 Lack or inhibition of mitochondrial Cx43 is associated with reduced mitochondrial potassium influx, which might affect mitochondrial respiration. Potassium 82-91 gap junction protein, alpha 1 Mus musculus 36-40 22421958-4 2012 Here we review our previous study of biophysical properties of I(ks) in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) showed that I(ks) in hESC-CMs is a coassembly channel with a stoichiometry other than 1:1, which could be further modulated by additional KCNE1. Potassium 65-67 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 270-275 21612807-2 2012 Potassium and glucose cellular uptake are intimately linked by insulin. Potassium 0-9 insulin Canis lupus familiaris 63-70 21612807-3 2012 We hypothesized that in canine hypoadrenocorticism, hyperkalaemia would stimulate insulin release as a protective mechanism, translocating potassium from the extracellular compartment to the intracellular compartment and also lower glucose concentrations. Potassium 139-148 insulin Canis lupus familiaris 82-89 23650596-2 2012 A novel GTP-hydrolysis mechanism is employed by MnmE, YqeH and FeoB, where a potassium ion plays a role analogous to the Arginine finger of the Ras-RasGAP system, to accelerate otherwise slow GTP hydrolysis rates. Potassium 77-86 RAS p21 protein activator 1 Homo sapiens 148-154 22496411-1 2012 Dietary potassium (K(+)) restriction and hypokalemia have been reported to change the abundance of most renal Na(+) and K(+) transporters and aquaporin-2 isoform, but results have not been consistent. Potassium 8-17 aquaporin 2 Rattus norvegicus 142-153 22549224-3 2012 We show that ANG II and potassium induce the expression of acyl-coenzyme A (CoA) thioesterase 2 and acyl-CoA synthetase 4, two enzymes involved in intramitochondrial AA generation/export system well characterized in other steroidogenic systems. Potassium 24-33 acyl-CoA synthetase long chain family member 4 Homo sapiens 100-121 22745159-2 2012 Among the 12 identified genes causal to heritable LQTS, ~90% of affected individuals harbor mutations in either KCNQ1 or human ether-a-go-go related genes (hERG), which encode two repolarizing potassium currents known as I(Ks) and I(Kr). Potassium 223-225 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 112-117 22404309-3 2012 We found that noggin, a known antagonist of bone morphogenic protein, induces ES cells to express genes involved in serotonergic differentiation, such as Nkx2.2, Pet-1, Sonic hedgehog, tryptophan hydroxylase 2, and serotonin transporter, as well as increases high potassium-induced release of serotonin. Potassium 264-273 noggin Mus musculus 14-20 22747613-2 2012 In this secondary analysis, the authors tested whether this enhanced insulin response to valsartan/hydrochlorothiazide was influenced by serum potassium levels, which were reduced to a lesser extent, when compared with amlodipine/hydrochlorothiazide. Potassium 143-152 insulin Homo sapiens 69-76 22168445-10 2012 CONCLUSION: Our results demonstrated for the first time that rat BMEPCs expressed intermediate-conductance Ca(2+) -activated potassium currents and volume-sensitive chloride currents, and corresponding genes and proteins of these two channels are KCNN4 and Clcn3 respectively. Potassium 125-134 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 247-252 22168445-10 2012 CONCLUSION: Our results demonstrated for the first time that rat BMEPCs expressed intermediate-conductance Ca(2+) -activated potassium currents and volume-sensitive chloride currents, and corresponding genes and proteins of these two channels are KCNN4 and Clcn3 respectively. Potassium 125-134 chloride voltage-gated channel 3 Rattus norvegicus 257-262 22481440-5 2012 We show here that RNAi-mediated knockdown of PCSK9 significantly reduced the death of potassium-deprived cerebellar granule neurons (CGN), as shown by reduced levels of nuclear phosphorylated c-Jun and activated caspase-3, as well as condensed apoptotic nuclei. Potassium 86-95 proprotein convertase subtilisin/kexin type 9 Homo sapiens 45-50 22481440-5 2012 We show here that RNAi-mediated knockdown of PCSK9 significantly reduced the death of potassium-deprived cerebellar granule neurons (CGN), as shown by reduced levels of nuclear phosphorylated c-Jun and activated caspase-3, as well as condensed apoptotic nuclei. Potassium 86-95 caspase 3 Homo sapiens 212-221 26069764-2 2012 Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium. Potassium 204-213 arginine vasopressin receptor 2 Homo sapiens 25-28 26069764-2 2012 Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium. Potassium 204-213 aquaporin 2 Homo sapiens 100-111 26069764-2 2012 Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium. Potassium 204-213 aquaporin 2 Homo sapiens 118-122 22650221-4 2012 Although there is a theoretical basis for the use of glucose-insulin-potassium infusion during AMI, lack of outcome efficacy (and inability to reach glycemic targets) in recent randomized trials has resulted in little enthusiasm for this strategy. Potassium 69-78 insulin Homo sapiens 61-68 22329368-0 2012 Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions. Potassium 104-113 Nha1p Saccharomyces cerevisiae S288C 67-71 22329368-2 2012 Lost potassium is taken up by the Trk1 and Trk2 uptake systems. Potassium 5-14 Trk1p Saccharomyces cerevisiae S288C 34-38 22329368-2 2012 Lost potassium is taken up by the Trk1 and Trk2 uptake systems. Potassium 5-14 Trk2p Saccharomyces cerevisiae S288C 43-47 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 69-78 Nha1p Saccharomyces cerevisiae S288C 161-165 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 69-78 Tok1p Saccharomyces cerevisiae S288C 193-197 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Nha1p Saccharomyces cerevisiae S288C 161-165 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Tok1p Saccharomyces cerevisiae S288C 193-197 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Nha1p Saccharomyces cerevisiae S288C 161-165 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Tok1p Saccharomyces cerevisiae S288C 193-197 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Nha1p Saccharomyces cerevisiae S288C 161-165 22329368-4 2012 A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. Potassium 129-138 Tok1p Saccharomyces cerevisiae S288C 193-197 22329368-5 2012 In trk1Delta trk2Delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. Potassium 36-45 Trk1p Saccharomyces cerevisiae S288C 3-7 22329368-5 2012 In trk1Delta trk2Delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. Potassium 36-45 Nha1p Saccharomyces cerevisiae S288C 77-81 22329368-5 2012 In trk1Delta trk2Delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. Potassium 36-45 Na(+)/Li(+)-exporting P-type ATPase ENA1 Saccharomyces cerevisiae S288C 86-90 22329368-5 2012 In trk1Delta trk2Delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. Potassium 36-45 Trk1p Saccharomyces cerevisiae S288C 153-157 22329368-5 2012 In trk1Delta trk2Delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. Potassium 36-45 Tok1p Saccharomyces cerevisiae S288C 173-177 22407650-7 2012 The potassium carrier mutant trh1 displayed different patterns of root gravitropism and DR5::GUS signal intensity in root apex cells compared with the wild type in response to NH(4)(+). Potassium 4-13 Potassium transporter family protein Arabidopsis thaliana 29-33 22950024-0 2012 Adaptation to potassium starvation of wild-type and K(+)-transport mutant (trk1,2) of Saccharomyces cerevisiae: 2-dimensional gel electrophoresis-based proteomic approach. Potassium 14-23 Trk1p Saccharomyces cerevisiae S288C 75-81 22418981-6 2012 Cox regression modeling found that higher baseline dietary sodium and the ratio of sodium to calorie or potassium were each independently associated with greater all-cause mortality. Potassium 104-113 cytochrome c oxidase subunit 8A Homo sapiens 0-3 22250216-1 2012 M1476I, a French Canadian founder mutation of Na+ channel Nav1.4, causes potassium-aggravated myotonia, with cold-induced myotonia as the most distinctive clinical feature. Potassium 73-82 sodium voltage-gated channel alpha subunit 4 Homo sapiens 58-64 22531785-8 2012 Interestingly, prevention of PFT-induced potassium efflux inhibits the formation of caspase-2 complex, leading to its inactivation, thus resisting apoptosis. Potassium 41-50 caspase 2 Homo sapiens 84-93 22642439-6 2012 CHPG was also able to induce modulation of M-type potassium current through mGluR1, but not as consistently as glutamate. Potassium 50-59 glutamate metabotropic receptor 1 Rattus norvegicus 76-82 22632146-5 2012 Furthermore, mRNA and protein levels of transporters of glutamate (GLT-1) and potassium (Kir4.1), functional markers of astrocytes, decreased at about the times that delayed neuronal death occurred. Potassium 78-87 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 89-95 22475983-0 2012 Fluorescence imaging of potassium ions in living cells using a fluorescent probe based on a thrombin binding aptamer-peptide conjugate. Potassium 24-33 coagulation factor II, thrombin Homo sapiens 92-100 22425651-6 2012 It also down-regulated the expression of Kv1.4 and increased the expression of Kv4.2 and Kv4.3, so it might through regulating the expression of the transient outward potassium current (Ito) to improve the cardiac function. Potassium 167-176 potassium voltage-gated channel subfamily A member 4 Rattus norvegicus 41-46 22425651-6 2012 It also down-regulated the expression of Kv1.4 and increased the expression of Kv4.2 and Kv4.3, so it might through regulating the expression of the transient outward potassium current (Ito) to improve the cardiac function. Potassium 167-176 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 79-84 22425651-6 2012 It also down-regulated the expression of Kv1.4 and increased the expression of Kv4.2 and Kv4.3, so it might through regulating the expression of the transient outward potassium current (Ito) to improve the cardiac function. Potassium 167-176 potassium voltage-gated channel subfamily D member 3 Rattus norvegicus 89-94 22366095-3 2012 In VAT, the expression of PCK1, PLIN, ADIPOQ and PPARG was inversely correlated with aldosterone levels; furthermore, PLIN and ADIPOQ gene expression was correlated with potassium levels. Potassium 170-179 perilipin 1 Homo sapiens 118-122 22366095-3 2012 In VAT, the expression of PCK1, PLIN, ADIPOQ and PPARG was inversely correlated with aldosterone levels; furthermore, PLIN and ADIPOQ gene expression was correlated with potassium levels. Potassium 170-179 adiponectin, C1Q and collagen domain containing Homo sapiens 127-133 22586403-2 2012 A reduction of the transient outward potassium current (I(to)) in mammalian heart failure is consistent with a reduced expression of potassium channel interacting protein 2 (KChIP2, a K(V)4 subunit). Potassium 37-46 potassium voltage-gated channel interacting protein 2 Homo sapiens 133-172 22512618-1 2012 In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log D and high ligand-lipophilicity efficiency (LLE) values. Potassium 48-57 neural proliferation, differentiation and control 1 Homo sapiens 86-89 26288050-3 2012 Potential-modulated attenuated total reflectance (PM-ATR) measurements show that the monomeric subpopulation undergoes oxidation/reduction with ks,app = 2 x 10(2) s(-1), independent of Pc orientation. Potassium 144-146 X-prolyl aminopeptidase 2 Homo sapiens 147-154 26288050-5 2012 For in-plane-oriented Pc aggregates, ks,app = 2 x 10(3) s(-1), whereas for upright Pc aggregates, ks,app = 7 x 10(2) s(-1). Potassium 37-39 X-prolyl aminopeptidase 2 Homo sapiens 40-47 22087608-7 2012 AM5 infusion also induced significant increases in urine volume (HD 2-fold increment, P<0.05) and urine sodium (2.7-fold increment, P<0.01), potassium (1.7-fold increment, P<0.05) and creatinine (1.4-fold increment, P<0.05) excretion and creatinine clearance (60% increment, P<0.05). Potassium 147-156 adrenomedullin 5 (putative) Homo sapiens 0-3 22155597-11 2012 Co-expression of KCND3/WT + SCN1Bb/R214Q induced a Kv4.3 current (transient outward potassium current, I(to)) 70.6% greater compared with KCND3/WT + SCN1Bb/WT (n = 10-11, P<0.01). Potassium 84-93 potassium voltage-gated channel subfamily D member 3 Homo sapiens 17-22 22155597-11 2012 Co-expression of KCND3/WT + SCN1Bb/R214Q induced a Kv4.3 current (transient outward potassium current, I(to)) 70.6% greater compared with KCND3/WT + SCN1Bb/WT (n = 10-11, P<0.01). Potassium 84-93 potassium voltage-gated channel subfamily D member 3 Homo sapiens 51-56 22586403-2 2012 A reduction of the transient outward potassium current (I(to)) in mammalian heart failure is consistent with a reduced expression of potassium channel interacting protein 2 (KChIP2, a K(V)4 subunit). Potassium 37-46 potassium voltage-gated channel interacting protein 2 Homo sapiens 174-180 22127737-1 2012 Structural determinants responsible for the substrate preference of the potassium-independent (ASPGA1) and -dependent (ASPGB1) asparaginases from Arabidopsis thaliana have been investigated. Potassium 72-81 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein Arabidopsis thaliana 95-101 22240917-7 2012 These findings indicate that serum potassium elevation is negatively related to partial agonistic activities for MR, and SM-368229 shows antihypertensive efficacy with minimal effect on serum potassium level, probably due to its partial agonistic property. Potassium 35-44 nuclear receptor subfamily 3, group C, member 2 Rattus norvegicus 113-115 22583083-5 2012 To this end, KCNE1/KCNQ1 was expressed in Xenopus oocytes with and without beta-catenin and the depolarization (up to + 80 mV) induced current (I(Ks)) was determined using the two-electrode voltage clamp. Potassium 146-148 potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog Xenopus laevis 13-18 22583083-6 2012 As a result, beta-catenin enhanced I(Ks) by 30%. Potassium 37-39 catenin beta 1 L homeolog Xenopus laevis 13-25 22583083-7 2012 The effect of beta-catenin on I(Ks) was not affected by actinomycin D (10 muM), an inhibitor of transcription, indicating that beta-catenin was not effective as transcription factor. Potassium 32-34 catenin beta 1 L homeolog Xenopus laevis 14-26 22583083-10 2012 In conclusion, beta-catenin enhances I(Ks) by increasing the KCNE1/KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane. Potassium 39-41 catenin beta 1 L homeolog Xenopus laevis 15-27 22583083-10 2012 In conclusion, beta-catenin enhances I(Ks) by increasing the KCNE1/KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane. Potassium 39-41 potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog Xenopus laevis 61-66 22583083-10 2012 In conclusion, beta-catenin enhances I(Ks) by increasing the KCNE1/KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane. Potassium 39-41 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 67-72 22127737-1 2012 Structural determinants responsible for the substrate preference of the potassium-independent (ASPGA1) and -dependent (ASPGB1) asparaginases from Arabidopsis thaliana have been investigated. Potassium 72-81 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein Arabidopsis thaliana 119-125 22539834-1 2012 The channel pore-forming alpha subunit Kv4.2 is a major constituent of A-type (I(A)) potassium currents and a key regulator of neuronal membrane excitability. Potassium 85-94 potassium voltage-gated channel, Shal-related family, member 2 Mus musculus 39-44 22469025-6 2012 CONCLUSION: A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS. Potassium 154-156 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 89-92 22471507-1 2012 Here we report the successful synthesis of superconducting potassium-doped few-layer graphene (K-doped FLG) with a transition temperature of 4.5 K, which is 1 order of magnitude higher than that observed in the bulk potassium graphite intercalation compound (GIC) KC(8) (T(c) = 0.39 K). Potassium 59-68 filaggrin Homo sapiens 103-106 21538577-2 2012 KSHV encodes a pro-angiogenic viral chemokine receptor (vGPCR) that promotes EC growth in vitro and KS-like tumors in mouse models. Potassium 0-2 K14 Human gammaherpesvirus 8 56-61 21538577-3 2012 vGPCR is therefore considered a viral oncogene that plays a crucial role in the pathobiology of KS. Potassium 96-98 K14 Human gammaherpesvirus 8 0-5 22275517-9 2012 Genotype differences in glycinergic mIPSCs were more evident during sustained stimulation by solutions with high potassium levels, suggesting that the estimated size of the readily releasable pool of glycine-containing vesicles was reduced in VGAT(+/-) mice. Potassium 113-122 solute carrier family 32 (GABA vesicular transporter), member 1 Mus musculus 243-247 22373544-4 2012 We establish the membrane ions" contributions (sodium, potassium, calcium and iron) mediated by water to the antagonism of these drugs at the 5-HT1A receptor. Potassium 55-64 5-hydroxytryptamine receptor 1A Homo sapiens 142-157 22373544-6 2012 Our results indicate that potassium, calcium and iron play a key role for the antagonistic activity of drugs at the 5-HT1A receptor. Potassium 26-35 5-hydroxytryptamine receptor 1A Homo sapiens 116-131 22305629-5 2012 A high potassium concentration was used to release CGRP from dura mater, isolated TG, and TNC in vitro. Potassium 7-16 calcitonin-related polypeptide alpha Rattus norvegicus 51-55 22415212-0 2012 Influence of methanandamide and CGRP on potassium currents in smooth muscle cells of small mesenteric arteries. Potassium 40-49 calcitonin-related polypeptide alpha Rattus norvegicus 32-36 22415212-4 2012 In the present study, the direct influence of the cannabinoid methanandamide and the neuropeptide CGRP on the membrane potassium ion (K(+)) currents of rat mesenteric myocytes was explored. Potassium 119-128 calcitonin-related polypeptide alpha Rattus norvegicus 98-102 21709053-12 2012 This drug triggers a potassium efflux via a mechanism which does not involve purinergic receptors and generates, in consequence, the activation of caspase-1 and the secretion of IL-1beta. Potassium 21-30 caspase 1 Mus musculus 147-156 21709053-12 2012 This drug triggers a potassium efflux via a mechanism which does not involve purinergic receptors and generates, in consequence, the activation of caspase-1 and the secretion of IL-1beta. Potassium 21-30 interleukin 1 beta Mus musculus 178-186 23576844-5 2012 Electrochemical parameter of Mb in Mb-GO-Nafion film such as apparent heterogeneous electron transfer rate constant (ks) and formal potential (Eo") were obtained. Potassium 117-119 myoglobin Homo sapiens 29-31 22323544-2 2012 In this work, we demonstrate that L. interrogans induces NLRP3 inflammasome-dependent secretion of IL-1beta through the alteration of potassium transport in bone marrow-derived macrophages. Potassium 134-143 interleukin 1 beta Mus musculus 99-107 22192952-0 2012 Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons. Potassium 69-78 carbonic anhydrase 1 Rattus norvegicus 103-106 21316179-2 2012 Because insulin therapy decreases serum potassium levels, which creates potential to precipitate a fatal cardiac arrhythmia in a patient with hypokalemia, the American Diabetes Association (ADA) recommends obtaining a serum potassium level before giving insulin. Potassium 40-49 insulin Homo sapiens 8-15 21316179-2 2012 Because insulin therapy decreases serum potassium levels, which creates potential to precipitate a fatal cardiac arrhythmia in a patient with hypokalemia, the American Diabetes Association (ADA) recommends obtaining a serum potassium level before giving insulin. Potassium 224-233 insulin Homo sapiens 8-15 21950312-8 2012 A potassium 5.5-5.9mmol/L occurred on >=1 occasion over follow-up in 11 patients (nine on spironolactone) and was predicted by baseline potassium >=5.0mmol/L and eGFR <=45 ml/min/1.73m(2) . Potassium 2-11 epidermal growth factor receptor Homo sapiens 168-172 22198508-0 2012 Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. Potassium 46-55 epidermal growth factor receptor Homo sapiens 67-71 22198508-0 2012 Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. Potassium 46-55 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 92-95 21946656-1 2012 OBJECTIVES: Insulin administration lowers plasma potassium concentration by augmenting intracellular uptake of potassium. Potassium 49-58 insulin Homo sapiens 12-19 21946656-1 2012 OBJECTIVES: Insulin administration lowers plasma potassium concentration by augmenting intracellular uptake of potassium. Potassium 111-120 insulin Homo sapiens 12-19 21946656-3 2012 Some studies suggest that insulin has an antikaliuretic effect although plasma potassium levels were poorly controlled. Potassium 79-88 insulin Homo sapiens 26-33 21946656-5 2012 We examined the relation between administered insulin and renal potassium excretion in critically ill patients under computer-assisted glucose and potassium regulation. Potassium 64-73 insulin Homo sapiens 46-53 21946656-17 2012 After multivariate analysis correcting for relevant variables (including diuretics, pH, potassium levels and renal sodium excretion), insulin administration was independently and positively associated with renal potassium excretion. Potassium 88-97 insulin Homo sapiens 134-141 21946656-17 2012 After multivariate analysis correcting for relevant variables (including diuretics, pH, potassium levels and renal sodium excretion), insulin administration was independently and positively associated with renal potassium excretion. Potassium 212-221 insulin Homo sapiens 134-141 21946656-20 2012 CONCLUSION: Insulin administration is associated with an increase in the renal potassium excretion in critically ill patients. Potassium 79-88 insulin Homo sapiens 12-19 22024150-7 2012 RESULTS: Electrophysiological investigations of KCNQ1/KCNE1 proteins coexpressed with USP2-45 or USP2-69 isoforms and Nedd4-2 in Xenopus laevis oocytes and mammalian cells revealed that both USP2 isoforms counter the Nedd4-2-specific downregulation of I(Ks). Potassium 254-256 potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog Xenopus laevis 54-59 21725920-0 2012 Nrf2 and Sp family synergistically enhance the expression of ion transporters in potassium-depleted conditions. Potassium 81-90 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 22147752-1 2012 TASK-3 (KCNK9) tandem-pore potassium channels provide a volatile anesthetic-activated and Galpha(q) protein- and acidic pH-inhibited potassium conductance important in neuronal excitability. Potassium 27-36 potassium two pore domain channel subfamily K member 9 Rattus norvegicus 8-13 22147752-1 2012 TASK-3 (KCNK9) tandem-pore potassium channels provide a volatile anesthetic-activated and Galpha(q) protein- and acidic pH-inhibited potassium conductance important in neuronal excitability. Potassium 27-36 G protein subunit alpha q Rattus norvegicus 90-99 22214817-4 2012 However, when grown under conditions that induce stress on the plasma membrane protonmotive force (PMF), such as high external potassium to reduce the electrical gradient or high external pH to reduce the proton chemical gradient, aha2 mutant plants show a growth retardation compared with wild-type plants. Potassium 127-136 H[+]-ATPase 2 Arabidopsis thaliana 231-235 22214817-7 2012 In addition, genome-wide gene expression profiling revealed the up-regulation of potassium transporters in aha2 mutants, indicating, as predicted, a close link between the PMF and potassium uptake at the plasma membrane. Potassium 81-90 H[+]-ATPase 2 Arabidopsis thaliana 107-111 22438021-0 2012 Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Potassium 44-53 Na+/H+ exchanger 1 Arabidopsis thaliana 15-19 22438021-0 2012 Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Potassium 44-53 sodium hydrogen exchanger 2 Arabidopsis thaliana 24-28 22250904-4 2012 Other functions of brain AQP4 involve potassium uptake and release by astrocytes, migration of glial cells, glial scarring, and astrocyte-to-astrocyte cell communication. Potassium 38-47 aquaporin 4 Homo sapiens 25-29 22357867-6 2012 We report that in cultured cerebellar granule neurons induced to die by low potassium treatment and in Abeta-treated cortical neurons, Mecp2-e2 expression is upregulated whereas expression of the Mecp2-e1 isoform is downregulated. Potassium 76-85 methyl CpG binding protein 2 Mus musculus 196-204 21845430-1 2012 Hypokalemic periodic paralysis (HypoPP) is an autosomal dominant disorder characterized by periodic attacks of muscle weakness associated with a decrease in the serum potassium level. Potassium 167-176 calcium voltage-gated channel subunit alpha1 S Homo sapiens 32-38 22367544-5 2012 Klf15 transcriptionally controls rhythmic expression of Kv channel-interacting protein 2 (KChIP2), a critical subunit required for generating the transient outward potassium current. Potassium 164-173 Kruppel-like factor 15 Mus musculus 0-5 22367544-5 2012 Klf15 transcriptionally controls rhythmic expression of Kv channel-interacting protein 2 (KChIP2), a critical subunit required for generating the transient outward potassium current. Potassium 164-173 Kv channel-interacting protein 2 Mus musculus 56-88 22367544-5 2012 Klf15 transcriptionally controls rhythmic expression of Kv channel-interacting protein 2 (KChIP2), a critical subunit required for generating the transient outward potassium current. Potassium 164-173 Kv channel-interacting protein 2 Mus musculus 90-96 22213115-7 2012 MAIN METHODS: The NOP receptor activity was evaluated by G-protein coupled inwardly rectifying potassium (GIRK) currents in rat vlPAG slices, and by inhibition of cAMP accumulation in HEK293 cells expressing NOP receptors or co-expressing NOP and MOP receptors. Potassium 95-104 prepronociceptin Homo sapiens 18-21 22298604-5 2012 RESULTS: In the group of patients who stopped the PLD (ie, continued the PID ), mean serum potassium levels increased 0.19 mEq/L (range -0.9 to 1.8 mEq/L). Potassium 92-101 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 22298604-5 2012 RESULTS: In the group of patients who stopped the PLD (ie, continued the PID ), mean serum potassium levels increased 0.19 mEq/L (range -0.9 to 1.8 mEq/L). Potassium 92-101 metastasis associated 1 family member 2 Homo sapiens 74-77 22298604-6 2012 After discontinuation of the PLD , serum potassium levels increased in 91 (59%) patients. Potassium 41-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 22298604-8 2012 In the group of patients who stopped the PID (ie, continued the PLD ), mean serum potassium levels decreased 0.40 mEq/L (range -2.6 to 0.7 mEq/L). Potassium 83-92 metastasis associated 1 family member 2 Homo sapiens 41-44 22298604-8 2012 In the group of patients who stopped the PID (ie, continued the PLD ), mean serum potassium levels decreased 0.40 mEq/L (range -2.6 to 0.7 mEq/L). Potassium 83-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-68 22298604-9 2012 Serum potassium levels decreased in 61 (70%) patients after discontinuation of the PID . Potassium 6-15 metastasis associated 1 family member 2 Homo sapiens 83-86 22340148-3 2012 RESULTS: Significant correlations were found between GAF scores and energy (kilocalories), carbohydrates, fibre, total fat, linoleic acid, riboflavin, niacin, folate, vitamin B6, vitamin B12, pantothenic acid, calcium, phosphorus, potassium, and iron (all P values < 0.05), as well as magnesium (r = 0.41, P < 0.001) and zinc (r = 0.35, P < 0.001). Potassium 231-240 fibroblast growth factor 9 Homo sapiens 53-56 22100668-7 2012 The SNP KCNE1 D85N (rs1805128), known to modulate an important potassium current in the heart, predicted diLQTS with an odds ratio of 9.0 (95% confidence interval, 3.5-22.9). Potassium 63-72 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 8-13 22038261-1 2012 The renal outer medullary potassium channel (ROMK) is an adenosine triphosphate-sensitive inward-rectifier potassium channel (Kir1.1 or KCNJ1) highly expressed in the cortical and medullary thick ascending limbs (TAL), connecting segment (CNT) and cortical collecting duct (CCD) in the mammalian kidney, where it serves to recycle potassium (K(+)) across the apical membrane in TAL and to secrete K(+) in the CNT and CCD. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 136-141 22038256-0 2012 Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport. Potassium 87-96 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-44 22038261-1 2012 The renal outer medullary potassium channel (ROMK) is an adenosine triphosphate-sensitive inward-rectifier potassium channel (Kir1.1 or KCNJ1) highly expressed in the cortical and medullary thick ascending limbs (TAL), connecting segment (CNT) and cortical collecting duct (CCD) in the mammalian kidney, where it serves to recycle potassium (K(+)) across the apical membrane in TAL and to secrete K(+) in the CNT and CCD. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 45-49 22038261-1 2012 The renal outer medullary potassium channel (ROMK) is an adenosine triphosphate-sensitive inward-rectifier potassium channel (Kir1.1 or KCNJ1) highly expressed in the cortical and medullary thick ascending limbs (TAL), connecting segment (CNT) and cortical collecting duct (CCD) in the mammalian kidney, where it serves to recycle potassium (K(+)) across the apical membrane in TAL and to secrete K(+) in the CNT and CCD. Potassium 26-35 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 57-132 22184322-0 2012 Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake. Potassium 102-111 cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus 0-7 21988371-5 2012 BDNF(+/-) mice also had a potentiated increase in dopamine levels following potassium (120 mM)-stimulation (10-fold) relative to wildtype controls (6-fold). Potassium 76-85 brain derived neurotrophic factor Mus musculus 0-4 21863227-4 2012 The aim of this study was to determine whether the increased abundance of sodium:potassium:chloride (Na(+):K(+):2Cl(-)) co-transporter (NKCC2) leads to enhanced sodium uptake by the TAL. Potassium 81-90 solute carrier family 12 member 1 Rattus norvegicus 136-141 22303293-1 2012 The Patchliner temperature-controlled automated patch clamp system was evaluated for testing drug effects on potassium currents through human ether-a-go-go related gene (hERG) channels expressed in Chinese hamster ovary cells at 35-37 C. IC(50) values for a set of reference drugs were compared with those obtained using the conventional voltage clamp technique. Potassium 110-119 ETS transcription factor ERG Homo sapiens 171-175 22149452-7 2012 RESULTS: AQP2 excretion increased during potassium supplementation, and free water clearance fell. Potassium 41-50 aquaporin 2 Homo sapiens 9-13 22095730-4 2012 METHODS AND RESULTS: We characterized the effects of A341V on the I(Ks) macromolecular channel complex in transfected Chinese hamster ovary cells and found a dominant-negative suppression of cAMP-dependent Yotiao-mediated I(Ks) upregulation on top of a dominant-negative reduction in basal current. Potassium 68-70 A-kinase anchoring protein 9 Homo sapiens 206-212 22095730-6 2012 Western blot analysis showed reduced phosphorylation of KCNQ1 at S27, even for heterozygous A341V, suggesting that phosphorylation defects in some (mutant) KCNQ1 subunits can completely suppress I(Ks) upregulation. Potassium 197-199 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 56-61 22095730-6 2012 Western blot analysis showed reduced phosphorylation of KCNQ1 at S27, even for heterozygous A341V, suggesting that phosphorylation defects in some (mutant) KCNQ1 subunits can completely suppress I(Ks) upregulation. Potassium 197-199 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 156-161 22095730-9 2012 CONCLUSIONS: Our results indicate the involvement of the KCNQ1-S6 region at/or around A341 in cAMP-dependent stimulation of I(Ks), a process that is under strong dominant-negative control, suggesting that tetrameric KCNQ1 phosphorylation is required. Potassium 126-128 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 57-62 22095730-9 2012 CONCLUSIONS: Our results indicate the involvement of the KCNQ1-S6 region at/or around A341 in cAMP-dependent stimulation of I(Ks), a process that is under strong dominant-negative control, suggesting that tetrameric KCNQ1 phosphorylation is required. Potassium 126-128 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 216-221 22084095-5 2012 The inhibitory effect of SP was found exclusively in neurons expressing acid-sensing ion channel 3, where SP enhances M-channel-like potassium currents through the NK1 receptor in a G protein-independent but tyrosine kinase-dependent manner. Potassium 133-142 tachykinin 1 Mus musculus 25-27 22084095-5 2012 The inhibitory effect of SP was found exclusively in neurons expressing acid-sensing ion channel 3, where SP enhances M-channel-like potassium currents through the NK1 receptor in a G protein-independent but tyrosine kinase-dependent manner. Potassium 133-142 acid-sensing (proton-gated) ion channel 3 Mus musculus 72-98 22084095-5 2012 The inhibitory effect of SP was found exclusively in neurons expressing acid-sensing ion channel 3, where SP enhances M-channel-like potassium currents through the NK1 receptor in a G protein-independent but tyrosine kinase-dependent manner. Potassium 133-142 tachykinin 1 Mus musculus 106-108 22084095-5 2012 The inhibitory effect of SP was found exclusively in neurons expressing acid-sensing ion channel 3, where SP enhances M-channel-like potassium currents through the NK1 receptor in a G protein-independent but tyrosine kinase-dependent manner. Potassium 133-142 tachykinin receptor 1 Mus musculus 164-176 22136504-9 2012 Serum potassium levels were significantly lower in ABV than in TDF treated patients. Potassium 6-15 sex determining region Y Homo sapiens 63-66 21030184-5 2012 Treatment with norepinephrine, sodium bicarbonate, and insulin improved both the hemodynamic situation and the serum potassium with subsequent regaining pacemaker actions even before additional hemodialysis normalized the potassium level. Potassium 117-126 insulin Homo sapiens 55-62 21030184-5 2012 Treatment with norepinephrine, sodium bicarbonate, and insulin improved both the hemodynamic situation and the serum potassium with subsequent regaining pacemaker actions even before additional hemodialysis normalized the potassium level. Potassium 222-231 insulin Homo sapiens 55-62 22038828-0 2012 Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis. Potassium 53-62 nerve growth factor Rattus norvegicus 32-35 22761619-4 2012 Therefore, we tested the hypothesis that IGF-1 and PI3K/Akt signaling, independently, decrease sarcolemmal potassium currents in cardiac myocytes of neonatal rats. Potassium 107-116 insulin-like growth factor 1 Rattus norvegicus 41-46 22183055-8 2012 Consistent with the expected effects of reducing a major neuronal v-SNARE, glutamate-selective, microelectrode array (MEA) measurements in specific hippocampal subregions of VAMP2(+/-) mice showed significant reductions in potassium-evoked glutamate release. Potassium 223-232 vesicle-associated membrane protein 2 Mus musculus 174-179 22896926-2 2012 Connexin 26 expression in the lateral wall may play a role in acquired hearing loss by maintaining the endocochlear potential and potassium concentration in the endolymph. Potassium 130-139 gap junction protein, beta 2 Rattus norvegicus 0-11 21922321-8 2012 Arginine-stimulated (p = 0.02) insulin secretion was reduced in vivo, which was further reflected by a reduction of glucose- and potassium-stimulated insulin secretion (p = 0.002 and p = 0.04, respectively) in human islets in vitro. Potassium 129-138 insulin Homo sapiens 150-157 21711166-5 2012 Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) +- 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Potassium 6-15 D-box binding PAR bZIP transcription factor Homo sapiens 81-84 22761619-4 2012 Therefore, we tested the hypothesis that IGF-1 and PI3K/Akt signaling, independently, decrease sarcolemmal potassium currents in cardiac myocytes of neonatal rats. Potassium 107-116 AKT serine/threonine kinase 1 Rattus norvegicus 56-59 21976771-12 2012 The conclusion is that both AtCHX21 and AtCHX23 act in potassium homeostasis within the female gametophyte and this is discussed in terms of the diversification of gene sequence and function within the CHX gene family. Potassium 55-64 cation/H+ exchanger 21 Arabidopsis thaliana 28-35 21976771-12 2012 The conclusion is that both AtCHX21 and AtCHX23 act in potassium homeostasis within the female gametophyte and this is discussed in terms of the diversification of gene sequence and function within the CHX gene family. Potassium 55-64 cation/H+ exchanger 23 Arabidopsis thaliana 40-47 22496969-5 2012 Univariate regressions showed that changes in urinary sodium/potassium ratio (beta = 1.99) and plasma renin activity (beta = -15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all P < 0.05). Potassium 61-70 selenium binding protein 1 Homo sapiens 207-210 22079268-1 2012 Inwardly rectifying potassium (Kir) channels are essential for maintaining normal potassium homeostasis and the resting membrane potential. Potassium 20-29 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 31-34 22190306-1 2012 BACKGROUND: Kv7.5 (KCNQ5) channels conduct M-type potassium currents in the brain, are expressed in skeletal muscle, and contribute to vascular muscle tone. Potassium 50-59 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 12-17 22190306-1 2012 BACKGROUND: Kv7.5 (KCNQ5) channels conduct M-type potassium currents in the brain, are expressed in skeletal muscle, and contribute to vascular muscle tone. Potassium 50-59 potassium voltage-gated channel subfamily Q member 5 Homo sapiens 19-24 22156587-3 2012 METHODS: We studied predialysis mortality and slopes of estimated glomerular filtration rate, eGFR) associated with serum potassium in 1,227 males with CKD. Potassium 122-131 epidermal growth factor receptor Homo sapiens 94-98 22156587-6 2012 Hypokalemia was associated with loss of kidney function independent of race: a 1 mEq/l lower potassium was associated with an adjusted difference in slopes of eGFR of -0.13 ml/min/1.73 m(2)/year (95% CI: -0.20 to -0.07), p < 0.001. Potassium 93-102 epidermal growth factor receptor Homo sapiens 159-163 21951015-9 2012 Lastly, we examined a potential role for hypokalemia as a contributory factor to the patient"s lethal arrhythmia by possible low-potassium-induced degradation of WT HERG and haplo-insufficiency of G816V HERG. Potassium 129-138 potassium voltage-gated channel subfamily H member 2 Homo sapiens 165-169 21951015-9 2012 Lastly, we examined a potential role for hypokalemia as a contributory factor to the patient"s lethal arrhythmia by possible low-potassium-induced degradation of WT HERG and haplo-insufficiency of G816V HERG. Potassium 129-138 potassium voltage-gated channel subfamily H member 2 Homo sapiens 203-207 21792084-6 2012 Likewise, Akt inhibition also reduces both glucose-stimulated and potassium depolarization-stimulated insulin secretion from INS-1 cells. Potassium 66-75 AKT serine/threonine kinase 1 Rattus norvegicus 10-13 21792084-6 2012 Likewise, Akt inhibition also reduces both glucose-stimulated and potassium depolarization-stimulated insulin secretion from INS-1 cells. Potassium 66-75 insulin 1 Rattus norvegicus 125-130 23251508-3 2012 Marked potassium release occurred within 5 min and hemolysis within 20 min in human red blood cells (RBC) exposed to venom or purified venom porin. Potassium 7-16 voltage dependent anion channel 1 Homo sapiens 141-146 23251508-6 2012 Recognizing that porin assembly can be inhibited by zinc, we found that zinc gluconate inhibited potassium efflux from RBC exposed to total venom or purified porin, and prolonged survival time in mice following venom injection. Potassium 97-106 voltage dependent anion channel 1 Homo sapiens 17-22 23251508-6 2012 Recognizing that porin assembly can be inhibited by zinc, we found that zinc gluconate inhibited potassium efflux from RBC exposed to total venom or purified porin, and prolonged survival time in mice following venom injection. Potassium 97-106 voltage dependent anion channel 1 Homo sapiens 158-163 23133669-2 2012 Unlike most voltage-gated K(+)-channels, hERG shows a low elementary conductance at physiological voltage and potassium concentration. Potassium 110-119 ETS transcription factor ERG Homo sapiens 41-45 22737060-6 2012 In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis. Potassium 72-81 Trk1p Saccharomyces cerevisiae S288C 101-105 22737060-6 2012 In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis. Potassium 72-81 Nha1p Saccharomyces cerevisiae S288C 112-116 23071770-3 2012 In particular, the interplay intracellular chloride accumulation via the GABA(A) receptor and extracellular potassium accumulation via the K/Cl co-transporter KCC2 in promoting GABA(A)-mediated excitation is complex. Potassium 108-117 solute carrier family 12 member 5 Homo sapiens 159-163 23110108-3 2012 Consistent with these data, voltage-independent and TRAM-34 sensitive potassium currents imputable to the KCa3.1 channel were recorded in the murine GL261 cell line and several primary human glioblastoma cells lines. Potassium 70-79 toll-like receptor adaptor molecule 2 Mus musculus 52-56 23110108-3 2012 Consistent with these data, voltage-independent and TRAM-34 sensitive potassium currents imputable to the KCa3.1 channel were recorded in the murine GL261 cell line and several primary human glioblastoma cells lines. Potassium 70-79 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 106-112 23037694-5 2012 We previously showed that valinomycin, a potassium selective ionophore, also caused release of cytochrome c from mitochondria without inducing PT. Potassium 41-50 cytochrome c, somatic Homo sapiens 95-107 23115641-1 2012 Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Potassium 109-118 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 0-5 23115641-1 2012 Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Potassium 109-118 potassium voltage-gated channel subfamily Q member 3 Homo sapiens 10-15 22724017-12 2012 In addition, both of the KS patients had a mutation in CHD7 (p.Q51X) or FGFR1 (c.91+2T>A). Potassium 25-27 chromodomain helicase DNA binding protein 7 Homo sapiens 55-59 22724017-12 2012 In addition, both of the KS patients had a mutation in CHD7 (p.Q51X) or FGFR1 (c.91+2T>A). Potassium 25-27 fibroblast growth factor receptor 1 Homo sapiens 72-77 22768222-5 2012 We show that activation of NALP3 depends on phagocytosis of dying cells, ATP release through pannexin-1 channels of dying autophagic cells, P(2)X(7) purinergic receptor activation, and on consequent potassium efflux. Potassium 199-208 NLR family, pyrin domain containing 3 Mus musculus 27-32 22606244-1 2012 Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Potassium 102-111 NLR family, pyrin domain containing 3 Mus musculus 52-57 22606244-9 2012 Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome. Potassium 123-132 NLR family, pyrin domain containing 3 Mus musculus 162-167 22606244-13 2012 For agents that inhibit translation through mechanisms that do not involve loss of potassium, high extracellular potassium suppresses IL-1ss processing through a mechanism that remains undefined. Potassium 113-122 interleukin 1 complex Mus musculus 134-138 22493723-2 2012 Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation. Potassium 0-9 aquaporin 4 Rattus norvegicus 39-50 22493723-2 2012 Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation. Potassium 0-9 aquaporin 4 Rattus norvegicus 52-56 22493723-11 2012 In conclusion, we find that elevation of extracellular potassium regulates AQP4 and astrocyte water permeability via intracellular signaling involving cAMP. Potassium 55-64 aquaporin 4 Rattus norvegicus 75-79 22393394-7 2012 CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation. Potassium 115-124 caspase 1 Homo sapiens 185-194 22109556-4 2011 Using computational modeling, we show that intrinsic potassium currents (I(A) and I(SK)) in projection neurons may combine with extrinsic inhibition from local interneurons to implement a dual latency code for both pheromone identity and intensity. Potassium 53-62 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 82-87 21455705-5 2011 The study showed that the combination of salt stress and potassium-deficient stress more significantly decreased nitrate uptake, plant growth, the activities of nitrate reductase, glutamate dehydrogenase, glutamate synthase, urease, glutamic-pyruvic transaminase, glutamic-oxaloace transaminase, sucrose-phosphate synthase, phosphoenolpyruvate carboxylase, and the synthesis of free amino acids, chlorophyll, and protein than those of each individual stress, respectively. Potassium 57-66 nitrate reductase [NADH] 1 Zea mays 161-178 21455705-5 2011 The study showed that the combination of salt stress and potassium-deficient stress more significantly decreased nitrate uptake, plant growth, the activities of nitrate reductase, glutamate dehydrogenase, glutamate synthase, urease, glutamic-pyruvic transaminase, glutamic-oxaloace transaminase, sucrose-phosphate synthase, phosphoenolpyruvate carboxylase, and the synthesis of free amino acids, chlorophyll, and protein than those of each individual stress, respectively. Potassium 57-66 glutamic dehydrogenase1 Zea mays 180-203 21455705-5 2011 The study showed that the combination of salt stress and potassium-deficient stress more significantly decreased nitrate uptake, plant growth, the activities of nitrate reductase, glutamate dehydrogenase, glutamate synthase, urease, glutamic-pyruvic transaminase, glutamic-oxaloace transaminase, sucrose-phosphate synthase, phosphoenolpyruvate carboxylase, and the synthesis of free amino acids, chlorophyll, and protein than those of each individual stress, respectively. Potassium 57-66 MLO-like protein 4 Zea mays 324-355 21595652-6 2011 KEY RESULTS: The potassium pulse produced a pH(i) increase of 0.18 +- 0.006 (n= 5), which was reduced by the a-L3 antibody (0.016 +- 0.019). Potassium 17-26 glucose-6-phosphate isomerase Homo sapiens 44-49 22074108-8 2011 Similarly, expression of apoB mRNA and protein was lower in pHBV1.3 transfected HepG2 cells than in pBlue-ks transfected HepG2 cells. Potassium 106-108 apolipoprotein B Homo sapiens 25-29 21538466-3 2011 We investigated whether pathogenic factors of HE, glutamine (Gln) and/or ammonia, induce alterations in the expression of glial potassium channels (Kir4.1, Kir2.1) and Na(+) -K(+) -2Cl(-) cotransporter-1 (NKCC1) in rat cerebral cortex and cultured rat cortical astrocytes and whether these alterations have consequences for potassium efflux and astrocytic swelling. Potassium 128-137 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 148-154 21744071-5 2011 The effect of intracellular Ang II on action potential duration was related to the inhibition of potassium conductance through PKC activation because Bis-1 (360 nM), a selective PKC inhibitor, abolished the effect of the peptide. Potassium 97-106 angiotensinogen Homo sapiens 28-34 21895724-0 2011 A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L. Potassium 23-25 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 72-77 21895724-1 2011 BACKGROUND: The hereditary long QT syndrome is characterized by prolonged ventricular repolarization that can be caused by mutations to the KCNQ1 gene, which encodes the alpha subunits of the cardiac potassium channel complex that carries the I(Ks) current (the beta subunits are encoded by KCNE1). Potassium 245-247 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 140-145 21895724-1 2011 BACKGROUND: The hereditary long QT syndrome is characterized by prolonged ventricular repolarization that can be caused by mutations to the KCNQ1 gene, which encodes the alpha subunits of the cardiac potassium channel complex that carries the I(Ks) current (the beta subunits are encoded by KCNE1). Potassium 245-247 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 291-296 21895724-9 2011 CONCLUSION: The KCNQ1-S277L mutation causes biophysical defects that result in dominant-negative reduction in KCNQ1 and I(Ks) current density, and a trafficking defect that results in reduced surface expression, both without affecting HERG/I(Kr) . Potassium 122-124 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 16-21 21945676-0 2011 Blocking of sodium and potassium ion-dependent adenosine triphosphatase-alpha1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis. Potassium 23-32 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 140-145 22078307-6 2011 RESULTS: Here, we reveal that the cagA gene displays strong signatures of positive selection in bacteria isolated from amerindian populations, using the Ka/Ks ratio. Potassium 156-158 S100 calcium binding protein A8 Homo sapiens 34-38 21997206-10 2011 Together, these results demonstrate that extracellular potassium generated by neuronal activity modulates Cx30-mediated gap junctional communication between glomerular astrocytes, indicating that strong neuroglial interactions take place at this first relay of olfactory information processing. Potassium 55-64 gap junction protein, beta 6 Mus musculus 106-110 22057188-2 2011 We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Potassium 23-32 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Mus musculus 14-19 22057188-2 2011 We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Potassium 23-32 nascent polypeptide associated complex subunit alpha 2 Homo sapiens 43-55 21075579-11 2011 Once an urgent situation has been handled with intravenous push of a 10% calcium salt, short-term measures should be started with agents that cause a transcellular shift of potassium, namely, insulin with glucose, beta2-agonist, and NaHCO(3). Potassium 173-182 insulin Homo sapiens 192-199 21791623-10 2011 In summary, GPER activation relaxes coronary artery smooth muscle by increasing potassium efflux via BK(Ca) channels and requires an intact cellular signaling mechanism. Potassium 80-89 G protein-coupled estrogen receptor 1 Homo sapiens 12-16 22009997-15 2011 CONCLUSIONS: An intravenous infusion including a dextrose:insulin ratio of 3.3:1, compared with a higher ratio, results in less hyperglycemia and appears to be as effective in decreasing potassium concentrations in newborns. Potassium 187-196 insulin Homo sapiens 58-65 21778142-0 2011 Voltage-gated potassium currents are targets of diurnal changes in estradiol feedback regulation and kisspeptin action on gonadotropin-releasing hormone neurons in mice. Potassium 14-23 KiSS-1 metastasis-suppressor Mus musculus 101-111 21778142-0 2011 Voltage-gated potassium currents are targets of diurnal changes in estradiol feedback regulation and kisspeptin action on gonadotropin-releasing hormone neurons in mice. Potassium 14-23 gonadotropin releasing hormone 1 Mus musculus 122-152 21855134-1 2011 A 4-amino-naphthalimide derived fluorophore with a triazacryptand moiety ligand was synthesized as a potassium ion (K(+)) sensor (KS1). Potassium 101-110 zinc finger protein 382 Homo sapiens 130-133 21855134-8 2011 KS1 was used to monitor K(+) efflux stimulated by adenosine-5"-triphosphate (ATP), amphotericin, and a mixture of nigericin, bumetanide and ouabain, demonstrating application of this material as an intracellular potassium ion sensor. Potassium 212-221 zinc finger protein 382 Homo sapiens 0-3 21908160-11 2011 We also noted that mineralocorticoid receptor inhibition prevented pregnancy-induced decrease in transient outward potassium current. Potassium 115-124 nuclear receptor subfamily 3, group C, member 2 Rattus norvegicus 19-45 21978672-1 2011 A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 muM), a promising anticancer target. Potassium 34-43 plasminogen activator, urokinase Homo sapiens 104-140 21978672-1 2011 A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 muM), a promising anticancer target. Potassium 34-43 plasminogen activator, urokinase Homo sapiens 142-145 21880468-0 2011 Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures. Potassium 13-22 carbonic anhydrase 3 Rattus norvegicus 75-78 22042987-6 2011 We found that Ci-KCNQ1 alone could be expressed in Xenopus laevis oocytes and produced a voltage-dependent potassium current, but that Ci-KCNQ1 was not properly modulated by KCNE1 and totally unaffected by coexpression of KCNE3. Potassium 107-116 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 17-22 21888984-1 2011 INTRODUCTION: Measurement of drug-induced inhibition of potassium current flow through the hERG channel is used to determine potency at the channel, which is used as an in vitro risk assessment for QTc interval prolongation in vivo. Potassium 56-65 ETS transcription factor ERG Homo sapiens 91-95 22260022-6 2011 The efficacy in HT-29 cells with high HERG potassium expression level is less potent than that in A549 cells with low expression level. Potassium 43-52 potassium voltage-gated channel subfamily H member 2 Homo sapiens 38-42 21855088-3 2011 We describe a patient with HypoPP who had a high serum potassium concentration after recovery from a recent paralysis, which complicated the correct diagnosis. Potassium 55-64 calcium voltage-gated channel subunit alpha1 S Homo sapiens 27-33 21781976-3 2011 Important steps in this process are the production of EETs in the astrocyte and the release of potassium, via two potassium channels (BK and KIR), into the perivascular space. Potassium 95-104 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 141-144 21699843-0 2011 Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Potassium 33-35 potassium voltage-gated channel subfamily KQT member 1 Cricetulus griseus 52-57 21903939-10 2011 CONCLUSIONS: We propose that HCN3 together with other members of the HCN channel family confer a depolarizing background current that regulates ventricular resting potential and counteracts the action of hyperpolarizing potassium currents in late repolarization. Potassium 220-229 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Mus musculus 29-33 23256274-5 2011 The activation of the nAChR causes a twisting motion of the receptor, which opens a gate allowing for the passage of sodium, potassium, and calcium cations through the cell membrane. Potassium 125-134 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 22-27 23346606-3 2011 Intensive insulin therapy is defined as an intravenous infusion of insulin and glucose with or without potassium. Potassium 103-112 insulin Homo sapiens 10-17 21819957-9 2011 Activating PTEN in these cancers may yield a new treatment strategy for PEL, KS, and similar PTEN wild-type lymphomas. Potassium 77-79 phosphatase and tensin homolog Homo sapiens 11-15 21553247-0 2011 BIT/SHPS-1 promotes antiapoptotic effect of BDNF on low potassium-induced cell death of cultured cerebellar granule neurons. Potassium 56-65 signal-regulatory protein alpha Rattus norvegicus 0-3 21553247-0 2011 BIT/SHPS-1 promotes antiapoptotic effect of BDNF on low potassium-induced cell death of cultured cerebellar granule neurons. Potassium 56-65 signal-regulatory protein alpha Rattus norvegicus 4-10 21553247-0 2011 BIT/SHPS-1 promotes antiapoptotic effect of BDNF on low potassium-induced cell death of cultured cerebellar granule neurons. Potassium 56-65 brain-derived neurotrophic factor Rattus norvegicus 44-48 21553247-3 2011 In this article, we have studied the role of BIT/SHPS-1 in the antiapoptotic function of BDNF on low potassium (LK)-induced cell death of cultured CGNs which is an in vitro model system of neuronal apoptosis during brain development. Potassium 101-110 signal-regulatory protein alpha Rattus norvegicus 45-48 21553247-3 2011 In this article, we have studied the role of BIT/SHPS-1 in the antiapoptotic function of BDNF on low potassium (LK)-induced cell death of cultured CGNs which is an in vitro model system of neuronal apoptosis during brain development. Potassium 101-110 brain-derived neurotrophic factor Rattus norvegicus 89-93 20549616-0 2011 The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons. Potassium 51-60 carbonic anhydrase 1 Homo sapiens 85-88 20549616-3 2011 The aim of this study was to investigate the actions of silver nano-particles (nano-Ag) on voltage-activated potassium currents in hippocampal CA1 neurons using whole cell patch-clamp technique. Potassium 109-118 carbonic anhydrase 1 Homo sapiens 143-146 21699843-0 2011 Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Potassium 33-35 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 58-63 21699843-1 2011 BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo. Potassium 71-73 potassium voltage-gated channel subfamily KQT member 1 Cricetulus griseus 94-99 21699843-1 2011 BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo. Potassium 71-73 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 100-105 21699843-3 2011 Protein kinase C (PKC), which is activated by alpha1 adrenergic receptor stimulation, is known to downregulate I(Ks) via phosphorylation of KCNE1 serine 102, but the underlying mechanism has remained enigmatic. Potassium 113-115 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 140-145 21699843-10 2011 KCNE1-S102A abolished the effect of PMA on I(Ks) currents and endocytosis. Potassium 45-47 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 0-5 21921144-6 2011 iGFR and eGFR had similar strengths of association with hyperkalemia/potassium level and with metabolic acidosis/bicarbonate level. Potassium 69-78 insulin like growth factor 1 receptor Homo sapiens 0-4 21671256-7 2011 Constitutive and potassium-evoked release of acetylcholine and dopamine was increased and apoptosis induced by hydrogen peroxide (H(2)O(2)) was inhibited in PCP4-induced PC12 cells. Potassium 17-26 Purkinje cell protein 4 Rattus norvegicus 157-161 21820436-0 2011 Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line. Potassium 59-68 arginine vasopressin Homo sapiens 0-11 21796099-5 2011 Electrophysiological recordings in Xenopus oocytes injected with HCN2 cRNA found that potassium was transported better than ammonium, each of which was transported significantly better than sodium, criteria that are compatible with a role for HCN2 in ammonium transport. Potassium 86-95 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Rattus norvegicus 65-69 21943416-1 2011 Potassium currents generated by voltage-gated potassium (Kv) channels comprising alpha-subunits from the Kv1, 2, and 3 subfamilies facilitate high-frequency firing of mammalian neurons. Potassium 0-9 potassium voltage-gated channel subfamily A member 2 Homo sapiens 105-111 21740026-7 2011 Comparing collagen assembly on the two types of mica at different potassium concentrations revealed that potassium binds to the negatively charged mica surface and neutralizes it, thereby reducing the binding affinity of collagen and enhancing surface diffusion. Potassium 66-75 MHC class I polypeptide-related sequence A Homo sapiens 147-151 21740026-7 2011 Comparing collagen assembly on the two types of mica at different potassium concentrations revealed that potassium binds to the negatively charged mica surface and neutralizes it, thereby reducing the binding affinity of collagen and enhancing surface diffusion. Potassium 105-114 MHC class I polypeptide-related sequence A Homo sapiens 48-52 21740026-7 2011 Comparing collagen assembly on the two types of mica at different potassium concentrations revealed that potassium binds to the negatively charged mica surface and neutralizes it, thereby reducing the binding affinity of collagen and enhancing surface diffusion. Potassium 105-114 MHC class I polypeptide-related sequence A Homo sapiens 147-151 21841064-6 2011 Compared with those with a GFR >= 50 ml/min per 1.73 m(2), having a GFR < 30 ml/min per 1.73 m(2) was associated with a three-fold higher risk of acidosis and growth failure and a four- to five-fold higher risk of anemia and elevated potassium and phosphate. Potassium 240-249 Rap guanine nucleotide exchange factor 5 Homo sapiens 71-74 21670672-3 2011 RECENT FINDINGS: A variation in sodium and potassium intake or plasma aldosterone changes the number of cleaved alpha and gamma-ENaC subunits and is associated with changes in ENaC currents. Potassium 43-52 sodium channel epithelial 1 subunit gamma Homo sapiens 122-132 21424384-7 2011 The combination of potassium-sparing diuretics plus a potassium supplement, start of the PID within the hospital and hospitalisation in non-internal medicine departments was associated with higher relative risk estimates for hyperkalaemia. Potassium 19-28 metastasis associated 1 family member 2 Homo sapiens 89-92 21653901-3 2011 Organ culture of endothelium-denuded ovine carotid arteries with 3 ng/ml VEGF-A(165) for 24 h differentially and significantly influenced potassium-induced (55% increase) and stretch-induced (36% decrease) stress-strain relations in adult (n = 18) but not term fetal (n = 21) arteries, suggesting that smooth muscle reactivity to VEGF is acquired during postnatal maturation. Potassium 138-147 vascular endothelial growth factor A Homo sapiens 73-77 21683152-0 2011 Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons. Potassium 77-86 mitogen-activated protein kinase 14 Homo sapiens 43-46 21742892-0 2011 KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity. Potassium 36-45 thioredoxin reductase 1 Homo sapiens 80-94 21799445-0 2011 Genetic variants in the renin-angiotensin-aldosterone system and blood pressure responses to potassium intake. Potassium 93-102 renin Homo sapiens 24-29 21799445-2 2011 We examined the association between genetic variants in the renin-angiotensin-aldosterone system and BP responses to potassium intervention. Potassium 117-126 renin Homo sapiens 60-65 21799445-6 2011 For example, the number of G alleles of the N554S missense mutation (rs5527) of NR3C2 was significantly associated with greater SBP responses to potassium intervention; mean [95% confidence interval (CI)] responses (mmHg) were -3.33 (-3.65 to -3.02) for genotype A/A and -5.47 (-6.64 to -4.29) for A/G, respectively (P value = 0.0004). Potassium 145-154 nuclear receptor subfamily 3 group C member 2 Homo sapiens 80-85 21799445-6 2011 For example, the number of G alleles of the N554S missense mutation (rs5527) of NR3C2 was significantly associated with greater SBP responses to potassium intervention; mean [95% confidence interval (CI)] responses (mmHg) were -3.33 (-3.65 to -3.02) for genotype A/A and -5.47 (-6.64 to -4.29) for A/G, respectively (P value = 0.0004). Potassium 145-154 selenium binding protein 1 Homo sapiens 128-131 21799445-7 2011 In addition, the number of C alleles of the A1166C variant (rs5186) in AGTR1 was significantly and inversely associated with SBP responses to potassium intervention; mean (95% CI) responses were -3.55 (-3.87 to -3.24) for genotype A/A, -2.45 (-3.27 to -1.62) for A/C, and 3.25 (-5.73 to 12.23) for CC (P value = 0.003). Potassium 142-151 angiotensin II receptor type 1 Homo sapiens 71-76 21799445-7 2011 In addition, the number of C alleles of the A1166C variant (rs5186) in AGTR1 was significantly and inversely associated with SBP responses to potassium intervention; mean (95% CI) responses were -3.55 (-3.87 to -3.24) for genotype A/A, -2.45 (-3.27 to -1.62) for A/C, and 3.25 (-5.73 to 12.23) for CC (P value = 0.003). Potassium 142-151 selenium binding protein 1 Homo sapiens 125-128 21799445-8 2011 CONCLUSION: These novel findings indicated that genetic variants in the renin-angiotensin-aldosterone system may play an important role in determining an individual"s BP responses to dietary potassium intake. Potassium 191-200 renin Homo sapiens 72-77 21906004-6 2011 Furthermore, translocation of mutant PKC was attenuated when the cells was treated with high potassium solution. Potassium 93-102 protein kinase C gamma Homo sapiens 37-40 22340870-10 2011 However, in NHBP group, the mean urinary sodium decreased by 1.7 mmol/24 h (t = 0.211, P = 0.417) and urinary potassium increased by 3.7 mmol/24 h (t" = 2.207, P = 0.015), together with the decrease of Na(+)/K(+) by 0.7 (t = 1.818, P = 0.036). Potassium 110-119 filamin A Homo sapiens 12-16 21843472-0 2011 Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state. Potassium 14-23 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 33-38 21843472-2 2011 A number of Kv7.1 pore mutants are sensitive to extracellular potassium. Potassium 62-71 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 12-17 21843472-3 2011 We hypothesized that extracellular potassium also modulates wild-type Kv7.1 channels. Potassium 35-44 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 70-75 21843472-4 2011 The Kv7.1 currents were measured in Xenopus laevis oocytes at different concentrations of extracellular potassium (1-50 mM). Potassium 104-113 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 4-9 21843472-5 2011 As extracellular potassium was elevated, Kv7.1 currents were reduced significantly more than expected from theoretical calculations based on the Goldman-Hodgkin-Katz flux equation. Potassium 17-26 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 41-46 21843472-8 2011 Similarly, the recovery from inactivation was slowed by potassium, suggesting that extracellular potassium stabilizes an inactivated state in Kv7.1 channels. Potassium 56-65 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 142-147 21843472-8 2011 Similarly, the recovery from inactivation was slowed by potassium, suggesting that extracellular potassium stabilizes an inactivated state in Kv7.1 channels. Potassium 97-106 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 142-147 21843472-9 2011 The effect of extracellular potassium was absent in noninactivating Kv7.1/KCNE1 and Kv7.1/KCNE3 channels, further supporting a stabilized inactivated state as the underlying mechanism. Potassium 28-37 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 68-73 21843472-9 2011 The effect of extracellular potassium was absent in noninactivating Kv7.1/KCNE1 and Kv7.1/KCNE3 channels, further supporting a stabilized inactivated state as the underlying mechanism. Potassium 28-37 potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog Xenopus laevis 74-79 21843472-9 2011 The effect of extracellular potassium was absent in noninactivating Kv7.1/KCNE1 and Kv7.1/KCNE3 channels, further supporting a stabilized inactivated state as the underlying mechanism. Potassium 28-37 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 84-89 21843472-9 2011 The effect of extracellular potassium was absent in noninactivating Kv7.1/KCNE1 and Kv7.1/KCNE3 channels, further supporting a stabilized inactivated state as the underlying mechanism. Potassium 28-37 potassium channel, voltage gated subfamily E regulatory beta subunit 3 S homeolog Xenopus laevis 90-95 21843472-11 2011 In a number of other Kv channels, including Kv1.5, Kv4.3, and Kv7.2-5 channels, currents were only minimally reduced by an increase in extracellular potassium as expected. Potassium 149-158 potassium voltage-gated channel subfamily A member 4 L homeolog Xenopus laevis 44-49 21843472-11 2011 In a number of other Kv channels, including Kv1.5, Kv4.3, and Kv7.2-5 channels, currents were only minimally reduced by an increase in extracellular potassium as expected. Potassium 149-158 potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog Xenopus laevis 51-56 21843472-12 2011 These results show that extracellular potassium modulates Kv7.1 channels and suggests that physiological changes in potassium concentrations may directly control the function of Kv7.1 channels. Potassium 38-47 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 58-63 21843472-12 2011 These results show that extracellular potassium modulates Kv7.1 channels and suggests that physiological changes in potassium concentrations may directly control the function of Kv7.1 channels. Potassium 38-47 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 178-183 21843472-12 2011 These results show that extracellular potassium modulates Kv7.1 channels and suggests that physiological changes in potassium concentrations may directly control the function of Kv7.1 channels. Potassium 116-125 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 58-63 21843472-12 2011 These results show that extracellular potassium modulates Kv7.1 channels and suggests that physiological changes in potassium concentrations may directly control the function of Kv7.1 channels. Potassium 116-125 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 178-183 21843472-13 2011 This may represent a novel regulatory mechanism of excitability and of potassium transport in tissues expressing Kv7.1 channels. Potassium 71-80 potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog Xenopus laevis 113-118 21849540-2 2011 Presymptomatic SCA1 mice show a reduction in the firing rate of Purkinje cells (both in vivo and in slices) associated with a reduction in the efficiency of the main glutamatergic synapse onto Purkinje cells and with increased A-type potassium current. Potassium 234-243 ataxin 1 Mus musculus 15-19 21849545-6 2011 Moreover, furosemide and bumetanide, two inhibitors of sodium-coupled and/or potassium-coupled chloride movement strongly modified the phase shift, suggesting an involvement of two neuronal cotransporters, NKCC1 (Na-K-Cl) and KCC2 (K-Cl) in the genesis of the optical signal. Potassium 77-86 solute carrier family 12, member 2 Mus musculus 206-211 21849545-6 2011 Moreover, furosemide and bumetanide, two inhibitors of sodium-coupled and/or potassium-coupled chloride movement strongly modified the phase shift, suggesting an involvement of two neuronal cotransporters, NKCC1 (Na-K-Cl) and KCC2 (K-Cl) in the genesis of the optical signal. Potassium 77-86 solute carrier family 12, member 5 Mus musculus 226-230 21732595-1 2011 Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. Potassium 0-9 BOC cell adhesion associated, oncogene regulated Homo sapiens 10-13 21593184-5 2011 GLP-1-infused rats displayed increased urine flow, fractional excretion of sodium, potassium, and bicarbonate compared with those rats that received vehicle (1% BSA/saline). Potassium 83-92 glucagon Rattus norvegicus 0-5 21782438-6 2011 Furthermore, we detected adaptive protein evolution of vkorc1 in M. spretus (Ka/Ks = 1.54-1.93) resulting in radical amino acid substitutions that apparently cause anticoagulant tolerance in M. spretus as a pleiotropic effect. Potassium 80-82 vitamin K epoxide reductase complex subunit 1 Homo sapiens 55-61 21628512-9 2011 These data suggest that CPE can be absorbed from the intestine into the circulation, followed by the binding of the toxin to internal organs to induce potassium leakage, which can cause death. Potassium 151-160 cpe Clostridium perfringens 24-27 21680658-9 2011 Application of small interfering RNA specific for KCNK5 decreased pH-sensitive potassium currents and also reduced the estrogen-induced proliferation of T47D cells. Potassium 79-88 potassium two pore domain channel subfamily K member 5 Homo sapiens 50-55 21220753-9 2011 The plasma potassium decreased by a mean of 1.0, 1.7, 2.1 and 2.1 mmol/L at 1, 2, 4 and 8 h, respectively. Potassium 11-20 solute carrier family 7 member 5 Homo sapiens 71-89 21710140-0 2011 Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons. Potassium 71-80 potassium channel tetramerization domain containing 7 Homo sapiens 47-52 21652713-5 2011 Consistent with these observations, the overexpression of InsP(6)Ks leads to the depletion of Akt phosphorylation and the induction of cell death. Potassium 65-67 AKT serine/threonine kinase 1 Homo sapiens 94-97 21641965-1 2011 The transcription factor E2F1 is upregulated when cerebellar granular neurons (CGNs) undergo apoptosis under potassium deprivation. Potassium 109-118 E2F transcription factor 1 Rattus norvegicus 25-29 21641965-5 2011 Furthermore, overexpression of E2F1 significantly promoted apoptotic progression in mouse CGNs following potassium deprivation but attenuated apoptosis in rat CGNs, whereas E2F1 lacking DNA binding ability (E2F1-M132) lost its pro-apoptotic role in mouse CGNs and anti-apoptotic role in rat CGNs. Potassium 105-114 E2F transcription factor 1 Mus musculus 31-35 21641965-6 2011 Together, our results demonstrated that upregulation of E2F1 by potassium deprivation promotes apoptosis in C57 mouse CGNs but antagonizes apoptosis in SD rat CGNs, suggesting opposing roles for E2F1 in regulating CGN fate. Potassium 64-73 E2F transcription factor 1 Mus musculus 56-60 21641965-6 2011 Together, our results demonstrated that upregulation of E2F1 by potassium deprivation promotes apoptosis in C57 mouse CGNs but antagonizes apoptosis in SD rat CGNs, suggesting opposing roles for E2F1 in regulating CGN fate. Potassium 64-73 cingulin Rattus norvegicus 118-121 21624428-0 2011 Decrease of prestin expression by increased potassium concentration in organotypic cultures of the organ of Corti of newborn rats. Potassium 44-53 solute carrier family 26 member 5 Rattus norvegicus 12-19 21624428-2 2011 In the present study, we examined the effects of increased extracellular potassium (K(+)) concentration on the expression of prestin mRNA and the transcription factors Gata-3 and Carf in the organotypic culture of the organ of Corti of newborn rats. Potassium 73-82 solute carrier family 26 member 5 Rattus norvegicus 125-132 21624428-5 2011 Potassium concentration of 35 and 55 mM induced a parallel decrease in prestin and Carf expression, but Gata-3 expression increased. Potassium 0-9 solute carrier family 26 member 5 Rattus norvegicus 71-78 21624428-5 2011 Potassium concentration of 35 and 55 mM induced a parallel decrease in prestin and Carf expression, but Gata-3 expression increased. Potassium 0-9 calcium responsive transcription factor Rattus norvegicus 83-87 21628512-10 2011 Finally, CPE pore complexes similar to those formed in tissue culture cells were detected in the intestine and liver, suggesting that (i) CPE actions are similar in vivo and in vitro and (ii) CPE-induced potassium release into blood may result from CPE pore formation in internal organs such as the liver. Potassium 204-213 cpe Clostridium perfringens 9-12 21700825-0 2011 A critically swift response: insulin-stimulated potassium and glucose transport in skeletal muscle. Potassium 48-57 insulin Homo sapiens 29-36 21734082-1 2011 BACKGROUND AND OBJECTIVES: Insulin has several physiologic actions that include stimulation of cellular glucose and potassium uptake. Potassium 116-125 insulin Homo sapiens 27-34 21734082-12 2011 Conclusions Insulin-stimulated intracellular uptake of glucose and potassium are independent of each other. Potassium 67-76 insulin Homo sapiens 12-19 21525372-6 2011 However, there was no difference between the two genotypes in potassium-stimulated release of CGRP, the number of action potentials generated by a ramp of depolarizing current, or mechanical hypernociception elicited by intraplantar injection of capsaicin. Potassium 62-71 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 94-98 21460635-8 2011 In contrast, ULK1, but not ULK2, is critical to induce the autophagic response of cerebellar granule neurons (CGN) to low potassium concentration in serum-free conditions. Potassium 122-131 unc-51 like autophagy activating kinase 1 Homo sapiens 13-17 21502286-8 2011 N/OFQ activated a postsynaptic, G-protein coupled, inwardly rectifying potassium (GIRK) current that was sensitive to G-protein inactivation, blocked by the GIRK blocker SCH23390, and occluded by the GABAB agonist and potent GIRK activator, baclofen. Potassium 71-80 prepronociceptin Homo sapiens 0-5 21891927-5 2011 RESULTS: When normal cells were exposed to 50 mM potassium buffer, which was used to induce depolarization, the KCNQ3 protein level significantly increased in the membrane fraction but decreased in the cytosolic fraction, whereas the opposite was true in patient cells. Potassium 49-58 potassium voltage-gated channel subfamily Q member 3 Homo sapiens 112-117 21891927-7 2011 Our results suggest that the altered expression of KCNQ3 in patient cells exposed to high extracellular potassium levels could possibly hinder normal function of the channel protein. Potassium 104-113 potassium voltage-gated channel subfamily Q member 3 Homo sapiens 51-56 21484879-4 2011 Two kinds of outward currents were found, an A-type (K(A) ) and delayed rectifier (K(DR) ) potassium currents. Potassium 91-100 kinase insert domain receptor Rattus norvegicus 83-88 22145415-0 2011 [The effect of potassium different concentrations on mRNA expression of protein StAR and cytochrome p-450(SCC) in human adrenocortical tissue]. Potassium 15-24 steroidogenic acute regulatory protein Homo sapiens 80-84 22145415-0 2011 [The effect of potassium different concentrations on mRNA expression of protein StAR and cytochrome p-450(SCC) in human adrenocortical tissue]. Potassium 15-24 serpin family B member 3 Homo sapiens 106-109 22145415-1 2011 The effect of different potassium concentrations on changes in steroidogenic acute regulatory protein (StAR) and cytochrome P-450(SCC) in human adrenal cortex tissue was studied. Potassium 24-33 steroidogenic acute regulatory protein Homo sapiens 63-101 22145415-1 2011 The effect of different potassium concentrations on changes in steroidogenic acute regulatory protein (StAR) and cytochrome P-450(SCC) in human adrenal cortex tissue was studied. Potassium 24-33 steroidogenic acute regulatory protein Homo sapiens 103-107 22145415-1 2011 The effect of different potassium concentrations on changes in steroidogenic acute regulatory protein (StAR) and cytochrome P-450(SCC) in human adrenal cortex tissue was studied. Potassium 24-33 serpin family B member 3 Homo sapiens 113-134 22145415-3 2011 Thus, potassium ions caused an enhancement of minerocorticoid synthesis in the adrenal cortex, which is associated with mechanisms that regulate the intensity of expression of StAR and cytochrome P-450(SCC) on a transcriptional level. Potassium 6-15 steroidogenic acute regulatory protein Homo sapiens 176-180 22145415-3 2011 Thus, potassium ions caused an enhancement of minerocorticoid synthesis in the adrenal cortex, which is associated with mechanisms that regulate the intensity of expression of StAR and cytochrome P-450(SCC) on a transcriptional level. Potassium 6-15 serpin family B member 3 Homo sapiens 185-206 21464611-11 2011 As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium. Potassium 244-253 NLR family, pyrin domain containing 3 Mus musculus 51-56 21498510-4 2011 In our studies we used the voltage-gated hKv1.3 channel, and the insertion of a cysteine at position V388C (Shaker position 438) generated a current through the alpha-pore in high potassium outside and an inward current at hyperpolarizing potentials carried by different cations like Na(+), Li(+), Cs(+), and NH(4)(+). Potassium 180-189 potassium voltage-gated channel subfamily A member 3 Homo sapiens 41-47 21454252-0 2011 Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. Potassium 79-88 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 27-31 21389090-10 2011 The downregulation of NHE3 and NCC may contribute to the BP-attenuating effect of dietary potassium associated with increased urinary sodium excretion. Potassium 90-99 solute carrier family 9 member A3 Rattus norvegicus 22-26 21389090-10 2011 The downregulation of NHE3 and NCC may contribute to the BP-attenuating effect of dietary potassium associated with increased urinary sodium excretion. Potassium 90-99 solute carrier family 12 member 3 Rattus norvegicus 31-34 21619990-1 2011 BACKGROUND: The purpose of this study was to determine whether polarized arrest using adenosine/lidocaine cold crystalloid cardioplegia in combination with the hibernation inductor delta-opioid receptor agonist pentazocine would give satisfactory myocardial protection rather than using depolarized supranormal potassium cardioplegia, supranormal potassium cardioplegia with pentazocine, or adenosine/lidocaine cardioplegia. Potassium 311-320 opioid receptor delta 1 Sus scrofa 181-202 21619990-1 2011 BACKGROUND: The purpose of this study was to determine whether polarized arrest using adenosine/lidocaine cold crystalloid cardioplegia in combination with the hibernation inductor delta-opioid receptor agonist pentazocine would give satisfactory myocardial protection rather than using depolarized supranormal potassium cardioplegia, supranormal potassium cardioplegia with pentazocine, or adenosine/lidocaine cardioplegia. Potassium 347-356 opioid receptor delta 1 Sus scrofa 181-202 21454252-0 2011 Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. Potassium 79-88 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 33-39 21566059-1 2011 Dietary potassium stimulates the surface expression of ROMK channels in the aldosterone-sensitive distal nephron, but the mechanism by which this occurs is incompletely understood. Potassium 8-17 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 55-59 21347582-0 2011 Upregulation of calbindin D28k in the late distal tubules in the potassium-loaded adrenalectomized mouse kidney. Potassium 65-74 calbindin 1 Mus musculus 16-30 21438014-0 2011 HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Potassium 29-38 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 6-11 21438014-0 2011 HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Potassium 29-38 C-X-C motif chemokine receptor 4 Rattus norvegicus 51-56 21566059-2 2011 Here, a high-potassium diet increased the transcription of microRNA (miR) 802 in the cortical collecting duct in mice. Potassium 13-22 microRNA 802 Mus musculus 59-77 21566059-3 2011 In addition, high-potassium intake decreased the expression of caveolin-1, whose 3" untranslated region contains the seed sequence of miR-802. Potassium 18-27 caveolin 1, caveolae protein Mus musculus 63-73 21566059-3 2011 In addition, high-potassium intake decreased the expression of caveolin-1, whose 3" untranslated region contains the seed sequence of miR-802. Potassium 18-27 microRNA 802 Mus musculus 134-141 21566059-9 2011 Taken together, miR-802 mediates the stimulatory effect of a high-potassium diet on ROMK channel activity by suppressing caveolin-1 expression, which leads to increased surface expression of ROMK channels in the distal nephron. Potassium 66-75 microRNA 802 Mus musculus 16-23 21566059-9 2011 Taken together, miR-802 mediates the stimulatory effect of a high-potassium diet on ROMK channel activity by suppressing caveolin-1 expression, which leads to increased surface expression of ROMK channels in the distal nephron. Potassium 66-75 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 84-88 21566059-9 2011 Taken together, miR-802 mediates the stimulatory effect of a high-potassium diet on ROMK channel activity by suppressing caveolin-1 expression, which leads to increased surface expression of ROMK channels in the distal nephron. Potassium 66-75 caveolin 1, caveolae protein Mus musculus 121-131 21566059-9 2011 Taken together, miR-802 mediates the stimulatory effect of a high-potassium diet on ROMK channel activity by suppressing caveolin-1 expression, which leads to increased surface expression of ROMK channels in the distal nephron. Potassium 66-75 potassium inwardly-rectifying channel, subfamily J, member 1 Mus musculus 191-195 21435166-12 2011 phosphorylated mgp was also found to be present in the first ks patient originally described. Potassium 61-63 matrix Gla protein Homo sapiens 15-18 21321244-2 2011 The potassium-dependent sodium/calcium exchangers NCKX3 (gene SLC24A3) and NCX1 (gene SLC8A1) play a critical role in the transport of intracellular calcium across the cell membrane in exchange for extracellular sodium ions. Potassium 4-13 solute carrier family 24 member 3 Homo sapiens 50-55 21321244-2 2011 The potassium-dependent sodium/calcium exchangers NCKX3 (gene SLC24A3) and NCX1 (gene SLC8A1) play a critical role in the transport of intracellular calcium across the cell membrane in exchange for extracellular sodium ions. Potassium 4-13 solute carrier family 24 member 3 Homo sapiens 62-69 21321244-2 2011 The potassium-dependent sodium/calcium exchangers NCKX3 (gene SLC24A3) and NCX1 (gene SLC8A1) play a critical role in the transport of intracellular calcium across the cell membrane in exchange for extracellular sodium ions. Potassium 4-13 solute carrier family 8 member A1 Homo sapiens 75-79 21321244-2 2011 The potassium-dependent sodium/calcium exchangers NCKX3 (gene SLC24A3) and NCX1 (gene SLC8A1) play a critical role in the transport of intracellular calcium across the cell membrane in exchange for extracellular sodium ions. Potassium 4-13 solute carrier family 8 member A1 Homo sapiens 86-92 22034819-4 2011 Two-microelectrode voltage clamp experiments had showed that the toxin inhibited Kv2.1 potassium currents expressed in Xenopus Laevis oocytes. Potassium 87-96 potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog Xenopus laevis 81-86 21576493-2 2011 The potassium channel, I(Ks), is important for cardiac repolarization and requires PIP(2) to activate. Potassium 25-27 prolactin induced protein Homo sapiens 83-86 21469677-10 2011 We show T7 RNAP arrest at the c-myb repeat in double-stranded DNA under conditions mimicking the cellular concentration of biomolecules and potassium ions, suggesting that the G4 structure formed in the c-myb repeat may represent a transcription roadblock in vivo. Potassium 140-149 MYB proto-oncogene, transcription factor Homo sapiens 30-35 21486764-8 2011 These data suggest an important role of KCC2-dependent potassium/chloride homeostasis under neurototoxic conditions and reveal a novel role of endogenous KCC2 as a neuroprotective molecule. Potassium 55-64 solute carrier family 12 member 5 Rattus norvegicus 40-44 21484263-4 2011 To assess this, we examined the effects of the female sex hormone beta-estradiol on the human ether-a-go-go-related gene (hERG)-encoded potassium current stably expressed in human embryonic kidney-293 (HEK) cells. Potassium 136-145 ETS transcription factor ERG Homo sapiens 122-126 21453644-10 2011 CONCLUSIONS: The m.3243A>G mutation not only underlies a dysfunction of the insulin-producing beta cell of the pancreas but also results in a reduction in adenosine triphosphate production of the strial marginal cells of the inner ear, thus diminishing the energy (in the form of potassium ion gradient) needed for the outer hair cells of the organ of Corti to amplify the soundwaves, particularly at high frequencies. Potassium 283-292 insulin Homo sapiens 79-86 20827508-0 2011 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: review of published reports. Potassium 23-32 insulin Homo sapiens 110-117 21470398-7 2011 High extracellular potassium and 10 mM tolbutamide abrogated the inhibition of insulin secretion by GA. Glyceraldehyde, dihydroxyacetone, methylpyruvate, GLP-1, and forskolin, an activator of adenylate cyclase, did not abrogate the inhibition. Potassium 19-28 insulin Homo sapiens 79-86 21183662-14 2011 Electrophysiological recordings from isolated CCK-GFP cells revealed these cells to possess a predominant outwardly rectifying potassium current. Potassium 127-136 cholecystokinin Mus musculus 46-49 21270092-4 2011 In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. Potassium 77-86 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 102-106 21241800-6 2011 In addition, expression of S277L and wild type KCNQ1 with KCNE1 resulted in a shift of the voltage-dependence of activation by -8.7mV compared to wild type I(Ks), indicating co-assembly of mutant and wild type subunits. Potassium 158-160 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 47-52 21241800-6 2011 In addition, expression of S277L and wild type KCNQ1 with KCNE1 resulted in a shift of the voltage-dependence of activation by -8.7mV compared to wild type I(Ks), indicating co-assembly of mutant and wild type subunits. Potassium 158-160 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 58-63 21396765-5 2011 Both FF and FH aptamer dimers exhibited a potassium-dependent inhibitory effect on thrombin-mediated fibrin gel formation, which was on average two-fold higher than those of canonical single stranded Fibri aptamers. Potassium 42-51 coagulation factor II, thrombin Homo sapiens 83-91 21214675-5 2011 The other markers for HSC, vimentin and CRBP1, also confirmed the decrease of HSC in the KS type. Potassium 89-91 vimentin Rattus norvegicus 27-35 21436285-2 2011 The discovery of WNK kinases (With No lysine = K) now offers new insight to this relationship because WNKs are a crucial molecular pathway connecting hormones such as angiotensin II and aldosterone to renal sodium and potassium transport. Potassium 218-227 angiotensinogen Homo sapiens 167-181 21454290-0 2011 Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons. Potassium 59-68 gastrin releasing peptide Homo sapiens 0-25 21454290-4 2011 Recordings from Per1 -fluorescent neurons in SCN slices several hours after GRP treatment revealed a significantly greater action potential frequency, a significant increase in voltage-activated outward current at depolarized potentials, and a significant increase in 4-aminopyridine-sensitive fast delayed rectifier (fDR) potassium currents when compared to vehicle-treated slices. Potassium 323-332 gastrin releasing peptide Homo sapiens 76-79 21402906-8 2011 Our results demonstrate that altered potassium subunit function influences epilepsy susceptibility and implicate Kcnv2 as an epilepsy gene. Potassium 37-46 potassium voltage-gated channel modifier subfamily V member 2 Homo sapiens 113-118 21233253-5 2011 Simulations predicted that chloroquine effectively blocks potassium flow by binding at the centre of the ion permeation vestibule of Kir2.1. Potassium 58-67 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 133-139 21338134-0 2011 Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: the effect of potassium concentration and ion exchange. Potassium 100-109 BCL2 apoptosis regulator Homo sapiens 77-81 21338134-7 2011 Furthermore, the spectral changes of bcl2mid when transitioning from sodium form to potassium form take place upon K(+) titration. Potassium 84-93 BCL2 apoptosis regulator Homo sapiens 37-41 21252158-0 2011 Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression. Potassium 58-67 potassium voltage-gated channel interacting protein 2 Rattus norvegicus 103-109 21191090-5 2011 N/OFQ-induced outward currents persisted in TTX, reversed near the potassium equilibrium potential, and displayed inward rectification, suggesting direct postsynaptic potassium channel activation. Potassium 67-76 prepronociceptin Homo sapiens 0-5 21205205-8 2011 Using electrophysiology, we found that an analogous mammalian AQP1 N76S mutant excluded protons and potassium ions, but leaked sodium ions, providing an argument for the overwhelming prevalence of Asn over other amino acids. Potassium 100-109 aquaporin 1 (Colton blood group) Homo sapiens 62-66 21278344-4 2011 All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1beta, a process that depended on potassium efflux but was independent of P2X7 receptor. Potassium 144-153 interleukin 1 beta Mus musculus 107-115 21209355-0 2011 Elevated potassium elicits recurrent surges of large GABAA-receptor-mediated post-synaptic currents in hippocampal CA3 pyramidal neurons. Potassium 9-18 carbonic anhydrase 3 Rattus norvegicus 115-118 20142818-7 2011 In agreement, higher amounts of dopamine were released from this brain region of NRG1-treated mice following high potassium stimulation. Potassium 114-123 neuregulin 1 Mus musculus 81-85 21173039-6 2011 The results suggest that activity of these three carriers is sodium/potassium-independent and affected differently by changes in pHo and DeltaPsi: Oatp1a1 was confirmed to be an electroneutral anion exchanger, whereas the function of both OATP1B1 and OATP1B3 was markedly affected by the magnitude of DeltaPsi. Potassium 68-77 solute carrier organic anion transporter family member 1B1 Homo sapiens 239-246 21364885-10 2011 A possible role for chloride ions is suggested: the nAChR selectivity was actually reduced by increased chloride gradient (membrane hyperpolarization), while it was increased, moving towards a channel preferentially permeable for potassium, when the chloride gradient was reduced. Potassium 230-239 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 52-57 21051417-4 2011 Moreover, insulin is the key component of glucose-insulin-potassium cocktail and exerts significant cardiovascular protective effect via a phosphatidylinositol 3"-kinase-protein kinase B-endothelial nitric oxide synthase (PI3K-Akt-eNOS)-dependent signalling mechanism in addition to its metabolic modulation, which renders it a potent organ protector in multiple clinical applications. Potassium 58-67 insulin Homo sapiens 10-17 21118817-4 2011 In cerebellar granule neurons (CGNs) primed to undergo apoptosis by low potassium treatment, expression of HDAC7 protein is reduced. Potassium 72-81 histone deacetylase 7 Mus musculus 107-112 21118817-6 2011 Forced expression of HDAC7 in cultured CGNs blocks low potassium-induced death, and shRNA-mediated suppression of its expression induces death in otherwise healthy neurons. Potassium 55-64 histone deacetylase 7 Mus musculus 21-26 21294877-5 2011 In addition, we demonstrate that induction of SP and ECR1-TAC1prom activity in these larger diameter neurones can be induced by potassium depolarisation suggesting that, in addition to capsaicin induction, transgene activity may be modulated by voltage gated calcium channels. Potassium 128-137 tachykinin precursor 1 Homo sapiens 58-62 20942808-2 2011 In Saccharomyces cerevisiae, the Nha1 Na(+) /H(+) -antiporter and Ena1 Na(+) -ATPase, mediate the efflux of toxic sodium and surplus potassium. Potassium 133-142 Nha1p Saccharomyces cerevisiae S288C 33-37 21143561-2 2011 Yeast strains lacking the PPZ1 and PPZ2 phosphatase genes, which aberrantly accumulate potassium, are sensitive to agents causing replicative stress or DNA damage and present a cell cycle delay in the G(1) /S phase. Potassium 87-96 salt homeostasis regulator Saccharomyces cerevisiae S288C 26-30 21143561-2 2011 Yeast strains lacking the PPZ1 and PPZ2 phosphatase genes, which aberrantly accumulate potassium, are sensitive to agents causing replicative stress or DNA damage and present a cell cycle delay in the G(1) /S phase. Potassium 87-96 salt homeostasis regulator Saccharomyces cerevisiae S288C 35-39 21143561-6 2011 As we reported previously, internal potassium accumulation activates the Slt2 MAP kinase pathway. Potassium 36-45 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 73-77 20672326-2 2011 In this study, we observed that BNP increased the tetraethylammonium chloride (TEA)-sensitive delayed rectifier outward potassium current (I(K)) in mouse Schwann cells (SCs) using whole-cell recording techniques. Potassium 120-129 natriuretic peptide type B Mus musculus 32-35 20927043-1 2011 ROMK1 channels are located in the apical membrane of the connecting tubule and cortical collecting duct and mediate the potassium secretion during normal dietary intake. Potassium 120-129 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-5 20927043-10 2011 Hence, angiotensin II may have an important role in suppressing potassium secretion during volume depletion. Potassium 64-73 angiotensinogen Homo sapiens 7-21 21278776-0 2011 Angiotensin II: a candidate for an aldosterone-independent mediator of potassium preservation during volume depletion. Potassium 71-80 angiotensinogen Homo sapiens 0-14 21278776-4 2011 now propose that angiotensin II inhibits the renal outer medullary potassium channel (ROMK1) through stimulation of the protein tyrosine kinase c-Src, perhaps acting as a signal to differentiate volume depletion from a high-potassium diet. Potassium 67-76 angiotensinogen Homo sapiens 17-31 21278776-4 2011 now propose that angiotensin II inhibits the renal outer medullary potassium channel (ROMK1) through stimulation of the protein tyrosine kinase c-Src, perhaps acting as a signal to differentiate volume depletion from a high-potassium diet. Potassium 67-76 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 86-91 21278776-4 2011 now propose that angiotensin II inhibits the renal outer medullary potassium channel (ROMK1) through stimulation of the protein tyrosine kinase c-Src, perhaps acting as a signal to differentiate volume depletion from a high-potassium diet. Potassium 67-76 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 144-149 21120454-5 2011 hERG channels were expressed in Xenopus laevis oocytes and human embryonic kidney (HEK 293) cells, and potassium currents were recorded using patch clamp and two-electrode voltage clamp electrophysiology. Potassium 103-112 ETS transcription factor ERG Homo sapiens 0-4 21461038-4 2011 Furthermore, systematic glucose-insulin-potassium infusion (GIK) has been studied to improve outcome after AMI. Potassium 40-49 insulin Homo sapiens 32-39 20880994-4 2011 Here, we show that single-stranded DNA modeled from the template strand of the BCL2 MBR, forms secondary structures that migrate faster on native PAGE in the presence of potassium, due to the formation of intramolecular G-quadruplexes. Potassium 170-179 BCL2 apoptosis regulator Homo sapiens 79-83 21405864-1 2011 We have studied the dynamics of chloride and potassium ions in the interior of the Outer membrane porin F (OmpF) under the influence of an external electric field. Potassium 45-54 voltage dependent anion channel 1 Homo sapiens 98-103 20696528-0 2011 GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus. Potassium 80-89 G protein-coupled estrogen receptor 1 Rattus norvegicus 0-5 20923597-9 2011 Intakes of PUFA (6-12 years), vitamins B1 (2-5 and 13-18 years), B2 (13-18 years), A (2-5 and 13-18 years) and E (13-18 years) were higher in those groups consuming >= 3 0 servings of WG/d; intakes of added sugars (2-5 years), vitamin C (2-5 and 6-12 years), potassium and sodium (6-12 years) were lower. Potassium 262-271 pumilio RNA binding family member 3 Homo sapiens 11-15 21084310-2 2011 The assembly of KCNQ1 with KCNE1 generates the delayed rectifier current I(Ks) in the heart. Potassium 75-77 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 16-21 21084310-2 2011 The assembly of KCNQ1 with KCNE1 generates the delayed rectifier current I(Ks) in the heart. Potassium 75-77 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 27-32 21176777-5 2011 Interestingly, we found that SVCT2 could be positively modulated by potassium-induced depolarization of myotubes. Potassium 68-77 solute carrier family 23 member 2 Gallus gallus 29-34 21106862-10 2011 Pioglitazone also suppressed potassium-mediated CYP11B2 induction, but not N6-2"-O-dibutyladenosine-3",5"-cyclic monophosphate stimulation. Potassium 29-38 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 48-55 21368885-0 2011 Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration. Potassium 97-106 caspase 8 Homo sapiens 29-36 20955764-5 2011 Each of the four VGCCs, P/Q-, N-, and L- and T-type are abundantly found in TG and TNC relative to the dura mater and each mediates a significant fraction of high potassium concentration induced CGRP release. Potassium 163-172 calcitonin-related polypeptide alpha Rattus norvegicus 195-199 20955764-8 2011 In the TG omega-conotoxin GVIA inhibited the potassium induced CGRP release significantly. Potassium 45-54 calcitonin-related polypeptide alpha Rattus norvegicus 63-67 20955764-11 2011 These results suggest that depolarization by high potassium releases CGRP, and the release is regulated by Ca2+ ions and voltage-gated calcium channels. Potassium 50-59 calcitonin-related polypeptide alpha Rattus norvegicus 69-73 21187374-7 2011 Posttranslational modification of the phloem-expressed Arabidopsis K(+) channel AKT2 taps this "potassium battery," which then efficiently assists the plasma membrane H(+)-ATPase in energizing the transmembrane phloem (re)loading processes. Potassium 96-105 potassium transport 2/3 Arabidopsis thaliana 80-84 21187374-7 2011 Posttranslational modification of the phloem-expressed Arabidopsis K(+) channel AKT2 taps this "potassium battery," which then efficiently assists the plasma membrane H(+)-ATPase in energizing the transmembrane phloem (re)loading processes. Potassium 96-105 plasma membrane H+-ATPase Arabidopsis thaliana 151-178 21051542-1 2011 The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of the proinflammatory cytokine IL-1beta. Potassium 57-66 NLR family pyrin domain containing 3 Homo sapiens 4-9 21051542-1 2011 The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of the proinflammatory cytokine IL-1beta. Potassium 57-66 interleukin 1 beta Homo sapiens 150-158 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 110-119 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 9-14 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 110-119 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 62-67 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 131-133 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 9-14 21059661-1 2011 In vivo, KCNQ1 alpha-subunits associate with the beta-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Potassium 131-133 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 62-67 21173039-6 2011 The results suggest that activity of these three carriers is sodium/potassium-independent and affected differently by changes in pHo and DeltaPsi: Oatp1a1 was confirmed to be an electroneutral anion exchanger, whereas the function of both OATP1B1 and OATP1B3 was markedly affected by the magnitude of DeltaPsi. Potassium 68-77 solute carrier organic anion transporter family member 1B3 Homo sapiens 251-258 21209188-5 2011 One such gene--KCNAB2--encodes the potassium channel auxiliary subunit Kvbeta2, which has been previously shown to modulate voltage-gated potassium currents in heterologous expression systems. Potassium 35-44 potassium voltage-gated channel, shaker-related subfamily, beta member 2 Mus musculus 15-21 21219845-2 2011 Aldosterone activates expression of KS-WNK1 and inhibits WNK4 via SGK1 - both leading to stimulation of ENaC and activation of ROMK, and increased potassium excretion. Potassium 147-156 WNK lysine deficient protein kinase 1 Homo sapiens 39-43 21219845-2 2011 Aldosterone activates expression of KS-WNK1 and inhibits WNK4 via SGK1 - both leading to stimulation of ENaC and activation of ROMK, and increased potassium excretion. Potassium 147-156 WNK lysine deficient protein kinase 4 Homo sapiens 57-61 21219845-2 2011 Aldosterone activates expression of KS-WNK1 and inhibits WNK4 via SGK1 - both leading to stimulation of ENaC and activation of ROMK, and increased potassium excretion. Potassium 147-156 serum/glucocorticoid regulated kinase 1 Homo sapiens 66-70 21209188-5 2011 One such gene--KCNAB2--encodes the potassium channel auxiliary subunit Kvbeta2, which has been previously shown to modulate voltage-gated potassium currents in heterologous expression systems. Potassium 35-44 potassium voltage-gated channel, shaker-related subfamily, beta member 2 Mus musculus 71-78 22178878-1 2011 BACKGROUND/AIMS: ROMK channels mediate potassium secretion and regulate NaCl reabsorption in the kidney. Potassium 39-48 potassium inwardly rectifying channel subfamily J member 1 S homeolog Xenopus laevis 17-21 21850764-5 2011 In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na(+)/K(+)-ATPase. Potassium 17-26 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 155-161 21850764-5 2011 In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na(+)/K(+)-ATPase. Potassium 66-75 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 155-161 21849775-8 2011 Positive linear correlations between serum albumin and potassium concentration were only found in the hypoK and normoK groups (p < 0.001). Potassium 55-64 albumin Homo sapiens 43-50 21865851-7 2011 Similarly, beta(3)-AR activation induced time-dependent shortening of action potential duration (APD), together with decrease of L-type calcium current (I(Ca,L)) and increase of inward rectifier potassium current (I(K1)) and transient outward potassium current (I(to)) in rapid pacing atrial myocytes. Potassium 195-204 adrenoceptor beta 3 Homo sapiens 11-21 21774764-2 2011 Based on kinetic properties and drug sensitivity it is composed of a slow (I(Ks)) and a rapid (I(Kr)) component, the latter is mediated by hERG channels. Potassium 77-79 ETS transcription factor ERG Homo sapiens 139-143 22179005-0 2011 Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1. Potassium 29-38 potassium voltage-gated channel modifier subfamily V member 2 Homo sapiens 16-22 20932251-2 2011 Such a desensitization process is triggered by the activation of the transient receptor potential vanilloid subtype 1 receptor channels (TRPV1) that open their cationic pores, permeable to sodium, potassium and calcium (Ca(2+)) ions. Potassium 197-206 transient receptor potential cation channel subfamily V member 1 Homo sapiens 137-142 22323035-3 2011 On admission, she presented with metabolic alkalosis with hypokalemia, a high urinary excretion of potassium, low plasma rennin activity and hypoaldosteronism. Potassium 99-108 Src homology 2 domain containing E Homo sapiens 14-17 22194651-10 2011 Moreover, AVP secretion was not detected by stimulation with a high potassium (50 mM) solution. Potassium 68-77 arginine vasopressin Rattus norvegicus 10-13 22001995-0 2011 Neuropeptide FF receptor modulates potassium currents in a dorsal root ganglion cell line. Potassium 35-44 neuropeptide FF-amide peptide precursor Rattus norvegicus 0-15 21335993-4 2011 Milk is an important source of minerals supporting growth (type II nutrients), such as potassium, magnesium, phosphorus and zinc, and the high lactose content also seems to support growth due to a prebiotic effect and improved absorption of minerals. Potassium 87-96 Weaning weight-maternal milk Bos taurus 0-4 22001995-3 2011 The whole-cell planar patch-clamp technique showed that dNPA, a selective NPFF(2) agonist, increased the voltage-dependent potassium outward currents (about 30 pA/pF) by 21%; this reversible effect on sustained delayed potassium currents is blocked by tetraethylammonium. Potassium 123-132 neuropeptide FF-amide peptide precursor Rattus norvegicus 74-78 22163310-7 2011 Electrophysiological characterization indicated that passive conductance with large delayed rectifying potassium current might be a uniform feature of non-induced radial glia-like cells. Potassium 103-112 ral guanine nucleotide dissociation stimulator,-like 1 Mus musculus 163-179 22145034-0 2011 SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. Potassium 57-66 potassium channel, subfamily T, member 1 Mus musculus 0-5 22073228-8 2011 I(Ks) resulting from co-expression of Kv7.1 with non-atrial fibrillation "38S" was greater than with any other construct. Potassium 2-4 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 38-43 22022562-7 2011 The C-terminal half of OFD1 is under relaxed selection with an elevated Ka/Ks ratio and clustered positively selected sites, whereas the N-terminal half is under stronger constraints. Potassium 75-77 OFD1 centriole and centriolar satellite protein Homo sapiens 23-27 21158686-1 2010 The voltage-gated potassium channel, human Ether-a-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Potassium 18-27 ETS transcription factor ERG Homo sapiens 71-75 22073228-11 2011 CONCLUSIONS: The results of our study indicate that N-terminal arginines in positions 32, 33, 36 of KCNE1 are important for reconstitution of I(Ks). Potassium 144-146 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 100-105 21915266-1 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. Potassium 104-106 KCNQ potassium channel Drosophila melanogaster 18-22 21915266-1 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. Potassium 104-106 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 39-44 21915266-1 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. Potassium 104-106 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 68-73 21625424-5 2011 All three drugs induced potassium efflux from the cells as a known mechanism for NLRP3 activation but the P2X7 receptor was not required for this process. Potassium 24-33 NLR family, pyrin domain containing 3 Mus musculus 81-86 21625424-7 2011 Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1. Potassium 111-120 interleukin 1 beta Mus musculus 81-89 21625424-7 2011 Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1. Potassium 111-120 NLR family, pyrin domain containing 3 Mus musculus 153-158 21625424-7 2011 Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1. Potassium 111-120 steroid sulfatase Mus musculus 159-162 21625424-7 2011 Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1. Potassium 111-120 caspase 1 Mus musculus 163-172 20870010-3 2010 Growing sensory neurons in 30 or 100 ng/mL of NGF for 7 days increases CGRP content and this increase augments the amount of CGRP that is released by high extracellular potassium. Potassium 169-178 calcitonin related polypeptide alpha Homo sapiens 125-129 20861505-8 2010 Angiotensin II receptor, type 1 (AGTR1), single-nucleotide polymorphism rs16860760 in the 3q24-q26.1 region was significantly associated with absolute and percent systolic BP responses to potassium (P=0.0008 and P=0.0006, respectively). Potassium 188-197 angiotensin II receptor type 1 Homo sapiens 0-31 20486869-2 2010 The final step in RAAS stimulation is aldosterone secretion by angiotensin II, which leads to increased renal tubular sodium absorption and potassium secretion. Potassium 140-149 angiotensinogen Homo sapiens 63-77 20808327-10 2010 However, potassium intake (mg/1000 kcal) was shown to be inversely associated with hypertension development (upper tertile: >1863.0 for women and >1657.2 for men) vs first tertile (IRR=0.65 (0.44-0.96), P for trend=0.025). Potassium 9-18 insulin receptor related receptor Homo sapiens 187-190 20861505-8 2010 Angiotensin II receptor, type 1 (AGTR1), single-nucleotide polymorphism rs16860760 in the 3q24-q26.1 region was significantly associated with absolute and percent systolic BP responses to potassium (P=0.0008 and P=0.0006, respectively). Potassium 188-197 angiotensin II receptor type 1 Homo sapiens 33-38 20861505-12 2010 Furthermore, the AGTR1 gene was a significant predictor of BP responses to potassium intake. Potassium 75-84 angiotensin II receptor type 1 Homo sapiens 17-22 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 110-112 mechanistic target of rapamycin kinase Homo sapiens 23-52 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 110-112 mechanistic target of rapamycin kinase Homo sapiens 54-58 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 110-112 mechanistic target of rapamycin kinase Homo sapiens 134-138 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 192-194 mechanistic target of rapamycin kinase Homo sapiens 23-52 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 192-194 mechanistic target of rapamycin kinase Homo sapiens 54-58 20883817-7 2010 The phosphorylation of mammalian target of rapamycin (mTOR) was also depressed in cells overexpressing InsP(6)Ks, suggesting that the mTOR pathway regulates autophagosomes generated by InsP(6)Ks. Potassium 192-194 mechanistic target of rapamycin kinase Homo sapiens 134-138 20936693-4 2010 PNMA1 expression increases in cerebellar granule neurons (CGNs) induced to die by low potassium (LK) and in cortical neurons following homocysteic acid (HCA) treament. Potassium 86-95 paraneoplastic antigen MA1 Mus musculus 0-5 20936693-7 2010 Ectopic expression of PNMA1 promotes apoptosis even in medium containing high potassium, a condition that normally ensures survival of CGNs. Potassium 78-87 paraneoplastic antigen MA1 Mus musculus 22-27 21224508-3 2010 Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by -62 mV, with a marked instantaneous current component evident on membrane depolarisation. Potassium 135-137 potassium voltage-gated channel subfamily KQT member 1 Cricetulus griseus 97-102 21224508-3 2010 Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by -62 mV, with a marked instantaneous current component evident on membrane depolarisation. Potassium 135-137 potassium voltage-gated channel subfamily KQT member 1 Cricetulus griseus 184-189 21224508-3 2010 Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by -62 mV, with a marked instantaneous current component evident on membrane depolarisation. Potassium 135-137 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 190-195 21224508-3 2010 Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by -62 mV, with a marked instantaneous current component evident on membrane depolarisation. Potassium 135-137 potassium voltage-gated channel subfamily KQT member 1 Cricetulus griseus 184-189 20970925-7 2010 Similarly, concentration-dependent inhibition of CGRP release was observed when deltorphin and morphine were administered in sequence prior to potassium stimulation. Potassium 143-152 calcitonin-related polypeptide alpha Rattus norvegicus 49-53 21437011-8 2010 The secretion of IL-1beta was also increased by nigericin in WT mice and the secretory effect of a combination of ivermectin with ATP in KO mice was suppressed in a medium containing a high concentration of potassium. Potassium 207-216 interleukin 1 beta Mus musculus 17-25 21106816-0 2010 Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice. Potassium 40-49 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 15-21 20638488-1 2010 By using a 2-DE based workflow, the proteome of wild and potassium transport mutant trk1,2 under optimal growth potassium concentration (50mM) has been analyzed. Potassium 57-66 Trk1p Saccharomyces cerevisiae S288C 84-88 20833965-2 2010 Interestingly, the expressed pore mutants of HERG and KvLQT1 downregulated the remaining reciprocal repolarizing currents, I(Ks) and I(Kr), without affecting the steady-state levels of the native polypeptides. Potassium 125-127 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 54-60 20585026-3 2010 We hypothesize that the antimalarial quinoline chloroquine exerts potent antiarrhythmic effects by interacting with the cytoplasmic domains of Kir2.1 (I(K1)), Kir3.1 (I(KACh)), or Kir6.2 (I(KATP)) and reducing inward rectifier potassium currents. Potassium 227-236 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 143-149 20585026-6 2010 Comparative molecular modeling and ligand docking of chloroquine in the intracellular domains of Kir2.1, Kir3.1, and Kir6.2 suggested that chloroquine blocks or reduces potassium flow by interacting with negatively charged amino acids facing the ion permeation vestibule of the channel in question. Potassium 169-178 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 97-103 20585026-6 2010 Comparative molecular modeling and ligand docking of chloroquine in the intracellular domains of Kir2.1, Kir3.1, and Kir6.2 suggested that chloroquine blocks or reduces potassium flow by interacting with negatively charged amino acids facing the ion permeation vestibule of the channel in question. Potassium 169-178 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens 105-111 20585026-6 2010 Comparative molecular modeling and ligand docking of chloroquine in the intracellular domains of Kir2.1, Kir3.1, and Kir6.2 suggested that chloroquine blocks or reduces potassium flow by interacting with negatively charged amino acids facing the ion permeation vestibule of the channel in question. Potassium 169-178 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 117-123 20659170-4 2010 We found for the first time that in the absence of Arl1p, Kha1p increases potassium, sodium and lithium tolerance, and can thus be categorized as an antiporter with broad substrate specificity. Potassium 74-83 Kha1p Saccharomyces cerevisiae S288C 58-63 20629190-7 2010 ATP-induced release of CatS required potassium efflux and both extracellular calcium influx and mobilization of intracellular calcium. Potassium 37-46 cathepsin S Felis catus 23-27 20801131-4 2010 We show that, although the two waveforms elicited from resting conditions as a single AP are very similar and belong to membranes sharing similar passive electrical properties, the modified membrane generating AP2 is a weaker current source than the one generating AP1, has different sensitivity to up/down-regulation of ion channels and to extracellular potassium, and a different electrical restitution profile. Potassium 355-364 transcription factor AP-2 alpha Homo sapiens 210-213 21104767-2 2010 NCKX3 (gene SLC24A3), a potassium-dependent sodium-/calcium exchanger, plays a critical role in the transport of one intracellular calcium and potassium ion across the cell membrane in exchange for four extracellular sodium ions. Potassium 24-33 solute carrier family 24 member 3 Rattus norvegicus 0-5 21104767-2 2010 NCKX3 (gene SLC24A3), a potassium-dependent sodium-/calcium exchanger, plays a critical role in the transport of one intracellular calcium and potassium ion across the cell membrane in exchange for four extracellular sodium ions. Potassium 24-33 solute carrier family 24 member 3 Rattus norvegicus 12-19 20615442-7 2010 Injection of NTN one day prior to 6-OHDA also led to significant protection against loss of both potassium- and amphetamine-evoked overflow of dopamine. Potassium 97-106 neurturin Rattus norvegicus 13-16 20573049-0 2010 AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana. Potassium 55-64 Na+/H+ (sodium hydrogen) exchanger 3 Arabidopsis thaliana 0-6 20573049-10 2010 The overall results indicate that AtNHX3 encodes a K+/H+ antiporter required for low-potassium tolerance during germination and early seedling development, and may function in K+ utilization and ion homeostasis in Arabidopsis. Potassium 85-94 Na+/H+ (sodium hydrogen) exchanger 3 Arabidopsis thaliana 34-40 20842761-3 2010 The objective of this study was to determine the effects of selective COX-2 inhibitors and non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) on serum potassium concentration and the electrocardiogram. Potassium 160-169 prostaglandin-endoperoxide synthase 2 Homo sapiens 70-75 20842761-7 2010 RESULTS: Compared to patients prescribed non-selective NSAIDs, those prescribed a selective COX-2 inhibitor had a higher risk of serum potassium increase greater than 5 mEq/L (OR, 2.56; 95%CI, 1.03-6.36). Potassium 135-144 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 21273684-0 2010 Gain of function of Kir4.1 channel increases cell resistance to changes of potassium fluxes and cell volume evoked by ammonia and hypoosmotic stress. Potassium 75-84 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 20-26 21273684-1 2010 The Kir4.1 channel is an inward rectifying potassium channel involved in the control of potassium and water movement in mammalian cells. Potassium 43-52 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 4-10 21273684-8 2010 The results demonstrate that the presence of Kir4.1 in cells increases their resistance to alterations of potassium fluxes and/or cell volume imposed by ammonia and hypotonicity. Potassium 106-115 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 45-51 20820615-0 2010 Sodium and potassium compounds of [(eta(6)-benzenecarboxylate)Cr(CO)(3)] and [(eta(6)-1,4-benzenedicarboxylate)Cr(CO)(3)]. Potassium 11-20 endothelin receptor type A Homo sapiens 36-39 20820615-0 2010 Sodium and potassium compounds of [(eta(6)-benzenecarboxylate)Cr(CO)(3)] and [(eta(6)-1,4-benzenedicarboxylate)Cr(CO)(3)]. Potassium 11-20 endothelin receptor type A Homo sapiens 79-82 21433378-0 2010 Discovery of a small molecule inhibitor of ROMK and Kir7.1 The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel (ROMK, Kir1.1, KCNJ1), a potassium channel located in the renal tubule, where it critically regulates sodium and potassium balance. Potassium 201-210 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 43-47 21433391-0 2010 Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel (ROMK, Kir1.1, KCNJ1), a potassium channel located in the renal tubule, where it critically regulates sodium and potassium balance. Potassium 221-230 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 43-47 20921400-6 2010 Moreover, the expression of the ROMK and BKCa potassium channels was modified in KS-WNK1(-/-) mice, indicating that KS-WNK1 is also a regulator of potassium transport in the distal nephron. Potassium 46-55 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Mus musculus 41-45 20921400-6 2010 Moreover, the expression of the ROMK and BKCa potassium channels was modified in KS-WNK1(-/-) mice, indicating that KS-WNK1 is also a regulator of potassium transport in the distal nephron. Potassium 46-55 WNK lysine deficient protein kinase 1 Mus musculus 84-88 20921400-6 2010 Moreover, the expression of the ROMK and BKCa potassium channels was modified in KS-WNK1(-/-) mice, indicating that KS-WNK1 is also a regulator of potassium transport in the distal nephron. Potassium 46-55 WNK lysine deficient protein kinase 1 Mus musculus 119-123 20660394-9 2010 Further characterization of the role of the R190Q-KCNQ1 mutation in the pathogenesis of long-QT syndrome type 1 revealed a dominant negative trafficking defect associated with a 70 to 80% reduction in I(Ks) current and altered channel activation and deactivation properties. Potassium 203-205 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 50-55 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 58-67 ETS transcription factor ERG Homo sapiens 38-42 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 105-114 ETS transcription factor ERG Homo sapiens 38-42 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 126-128 ETS transcription factor ERG Homo sapiens 38-42 20535583-2 2010 RESULTS: Matrine inhibited HERG potassium current in a dose-dependent manner, and the 50% inhibitory concentration (IC IC(50)) was 411+-23 mumol/L. Potassium 32-41 potassium voltage-gated channel subfamily H member 2 Homo sapiens 27-31 20626758-0 2010 Effects of carvedilol on delayed rectifier and transient inactivating potassium currents in rat hippocampal CA1 neurons. Potassium 70-79 carbonic anhydrase 1 Rattus norvegicus 108-111 20595684-7 2010 Instead, suppression of sEH activity seemed to be responsible for the 11,12-EET-mediated enhanced inhibition of ENaC in animals on a high-potassium diet. Potassium 138-147 epoxide hydrolase 2 Rattus norvegicus 24-27 20595684-10 2010 In conclusion, high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity, respectively. Potassium 28-37 epoxide hydrolase 2 Rattus norvegicus 151-154 20813867-7 2010 Furthermore, a potassium load, sodium depletion, and aldosterone infusion each significantly reduced miR-192 expression in the kidney. Potassium 15-24 microRNA 192 Homo sapiens 101-108 20813867-8 2010 Taken together, these results suggest a miR-driven mechanism of gene regulation by aldosterone and a role for miR-192 in the regulation of sodium and potassium balance in the kidney. Potassium 150-159 microRNA 192 Homo sapiens 110-117 20970606-3 2010 OBJECTIVE: To evaluate the potassium and magnesium changes due to converting patients from CNIs to mTOR inhibitors. Potassium 27-36 mechanistic target of rapamycin kinase Homo sapiens 99-103 20488163-2 2010 While Kv1.3 is responsible for the voltage-dependent potassium current in T-cells, in macrophages this K(+) current is generated by the association of Kv1.3 and Kv1.5. Potassium 53-62 potassium voltage-gated channel subfamily A member 3 Homo sapiens 6-11 20853142-0 2010 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: a unique clinical/physiologic exercise in internal potassium balance. Potassium 23-32 insulin Homo sapiens 110-117 20853142-0 2010 Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: a unique clinical/physiologic exercise in internal potassium balance. Potassium 170-179 insulin Homo sapiens 110-117 20853142-4 2010 Calculations of transcellular potassium shifts based on the combined effects of insulin-the increase in the electrical potential differences (hyperpolarization) of the cell membranes and the correction of the hyperglycemic intracellular dehydration through decrease in serum glucose concentration-produced quantitative predictions of the decrease in serum K(+) similar to the reported changes in serum K(+) during treatment of DH with insulin. Potassium 30-39 insulin Homo sapiens 80-87 20853142-4 2010 Calculations of transcellular potassium shifts based on the combined effects of insulin-the increase in the electrical potential differences (hyperpolarization) of the cell membranes and the correction of the hyperglycemic intracellular dehydration through decrease in serum glucose concentration-produced quantitative predictions of the decrease in serum K(+) similar to the reported changes in serum K(+) during treatment of DH with insulin. Potassium 30-39 insulin Homo sapiens 435-442 20853142-5 2010 The lessons from analyzing serum K(+) changes during treatment of DH with insulin are applicable to other conditions where internal potassium balance is called upon to protect serum K(+), such as the postprandial state. Potassium 132-141 insulin Homo sapiens 74-81 20558181-4 2010 These "cells" between mica sheets are filled with potassium ions, and they provide an environment in which: polymer entropy is low; cyclic wetting and drying can occur; molecules can evolve in isolated spaces and also migrate and ligate to form larger molecules. Potassium 50-59 MHC class I polypeptide-related sequence A Homo sapiens 22-26 20616305-0 2010 Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Potassium 8-17 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 38-43 20831751-10 2010 Reduced activity of Kir4.1 channels in astrocytes of D2 mice is associated with deficits in potassium and glutamate buffering. Potassium 92-101 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 20-26 20616716-1 2010 PURPOSE OF REVIEW: We integrate recent evidence that demonstrates the importance of the gastric (HKalpha1) and nongastric (HKalpha2)-containing hydrogen potassium adenosine triphosphatases (H,K-ATPases) on physiological function and their role in potassium (K), sodium (Na), and acid-base balance. Potassium 153-162 ATPase, H+/K+ transporting, nongastric, alpha polypeptide Mus musculus 123-131 20570675-7 2010 In contrast, a significant decrease in postsynaptic baclofen-induced potassium currents was seen in SSADH KO mice. Potassium 69-78 aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus 100-105 20570675-9 2010 Finally, adenosine-induced potassium currents were also reduced in SSADH KO mice, which could suggest heterologous desensitization of the G-protein dependent effectors, leading to a reduction in G-protein coupled inwardly rectifying potassium (GIRK) channel responses. Potassium 27-36 aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus 67-72 20432466-3 2010 We find that M3GFP-BDNF induced to differentiate significantly accumulate BDNF and undergone to high potassium-mediated depolarization, show rapid BDNF recycle and activation of Trk receptors signaling. Potassium 101-110 brain derived neurotrophic factor Homo sapiens 13-23 20432466-3 2010 We find that M3GFP-BDNF induced to differentiate significantly accumulate BDNF and undergone to high potassium-mediated depolarization, show rapid BDNF recycle and activation of Trk receptors signaling. Potassium 101-110 brain derived neurotrophic factor Homo sapiens 19-23 20557424-0 2010 Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor. Potassium 36-45 oxytocin receptor Homo sapiens 124-141 20450907-6 2010 Furthermore, using [35S]GTPgammaS binding determination at CHO-halpha2B or CHO-halpha2A cell membranes and G protein coupled inwardly rectifying potassium (GIRK) current recordings in Xenopus oocytes expressing halpha2B, partial agonist activity of (+)8-OH-DPAT at the respective receptors was confirmed in these two different functional assays. Potassium 145-154 potassium inwardly rectifying channel subfamily J member 3 L homeolog Xenopus laevis 156-160 20600123-3 2010 We report solid-state NMR chemical shift fingerprints of two distinct conformations of the selectivity filter; significant changes are observed in the chemical shifts of key residues in the filter as the potassium ion concentration is changed from 50 mM to 1 muM. Potassium 204-213 latexin Homo sapiens 259-262 20720114-1 2010 Expressed metabotropic group 1 glutamate mGluR5 receptors and nucleotide P2Y1 receptors (P2Y1Rs) show promiscuous ion channel coupling in sympathetic neurons: their stimulation inhibits M-type [Kv7, K(M)] potassium currents and N-type (Ca(V)2.2) calcium currents (Kammermeier and Ikeda, 1999; Brown et al., 2000). Potassium 205-214 glutamate receptor, ionotropic, kainate 1 Mus musculus 41-47 20720114-1 2010 Expressed metabotropic group 1 glutamate mGluR5 receptors and nucleotide P2Y1 receptors (P2Y1Rs) show promiscuous ion channel coupling in sympathetic neurons: their stimulation inhibits M-type [Kv7, K(M)] potassium currents and N-type (Ca(V)2.2) calcium currents (Kammermeier and Ikeda, 1999; Brown et al., 2000). Potassium 205-214 purinergic receptor P2Y1 Homo sapiens 73-77 20600123-4 2010 Potassium ion titration studies reveal that the site-specific K(d) for K(+) binding at the key pore residue Val76 is on the order of approximately 7 muM and that a relatively high sample hydration is necessary to observe the low-K(+) conformer. Potassium 0-9 latexin Homo sapiens 149-152 20678225-4 2010 Forced expression of KChIP1 in cultured hippocampal neurons increased the frequency of miniature inhibitory postsynaptic currents (mIPSCs), reduced paired pulse facilitation of autaptic IPSCs, and decreases potassium current density. Potassium 207-216 potassium voltage-gated channel interacting protein 1 Homo sapiens 21-27 20678225-5 2010 Furthermore, genetic ablation of KChIP1 potentiated potassium current density in neurons and caused a robust enhancement of anxiety-like behavior in mice. Potassium 52-61 Kv channel-interacting protein 1 Mus musculus 33-39 20333436-0 2010 Potassium and sodium transport in non-animal cells: the Trk/Ktr/HKT transporter family. Potassium 0-9 neurotrophic receptor tyrosine kinase 1 Homo sapiens 56-59 20175205-3 2010 We therefore examined PrP effects on a suite of potassium (K(+)) conductances that govern excitability of basal forebrain neurons. Potassium 48-57 prion protein Rattus norvegicus 22-25 20175205-7 2010 PrP(106-126) application also evoked a depression of the delayed rectifier (I(K)) and transient outward (I(A)) potassium currents. Potassium 111-120 prion protein Rattus norvegicus 0-3 20439438-4 2010 TROX-1 preferentially inhibited potassium-triggered calcium influx through recombinant Ca(v)2.2 channels under depolarized conditions (IC(50) = 0.27 microM) compared with hyperpolarized conditions (IC(50) > 20 microM). Potassium 32-41 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 87-95 20434582-5 2010 As for other infections causing NRLP3 inflammasome assembly, caspase-1 activation in monocytes is triggered by potassium efflux and reactive oxygen species production. Potassium 111-120 caspase 1 Homo sapiens 61-70 20424930-5 2010 Following our initial findings with platelet endothelial cell adhesion molecule (PECAM)-1, our studies have revealed a key role for potassium ion permeability in regulating integrin-dependent binding of apoptotic cells by macrophages and their subsequent response to proinflammatory stimuli. Potassium 132-141 platelet and endothelial cell adhesion molecule 1 Homo sapiens 36-89 19850109-2 2010 AQP4 is a critical component of an integrated water and potassium homeostasis. Potassium 56-65 aquaporin 4 Homo sapiens 0-4 20678632-6 2010 Cytochrome c complexed with DCH18C6 in the PEG-rich phase was quantitatively recovered into a salt-rich phase using K(2)SO(4) by ion exchange of potassium ion and cationic protein in the cationic protein complex with DCH18C6. Potassium 145-154 cytochrome c, somatic Homo sapiens 0-12 20466422-5 2010 The presence of Gal at the concentrations of 10(-10) and 10(-8) M in the incubative media enriched in potassium ions excess was the cause of diminished AVP release from the NH and from the Hth-NH explant, respectively. Potassium 102-111 galanin and GMAP prepropeptide Rattus norvegicus 16-19 20026249-8 2010 Here, we critically discuss the experimental evidence concerning: (1) molecular and functional interplay of aquaporin 4, the major aquaporin protein in astroglial cells, with potassium and gap-junctional channels that are involved in extracellular potassium buffering. Potassium 175-184 aquaporin 4 Homo sapiens 108-119 20109536-6 2010 Our transcriptional profiling of injured rat cords suggests that elevated AQP4-mediated water influx accompanies increased uptake of chloride and potassium ions which represents a protective astrocytic reaction to hypoxia. Potassium 146-155 aquaporin 4 Rattus norvegicus 74-78 20399258-5 2010 Ka/Ks analysis indicates that the SPOPL genes are under functional constraints implicating biological functions. Potassium 3-5 speckle type BTB/POZ protein like Homo sapiens 34-39 20498229-2 2010 MiRP3 is found to co-localize with Kv4.2 subunits that contribute to cardiac transient outward potassium currents (I(to)). Potassium 95-104 potassium voltage-gated channel subfamily E regulatory subunit 4 Homo sapiens 0-5 20498229-2 2010 MiRP3 is found to co-localize with Kv4.2 subunits that contribute to cardiac transient outward potassium currents (I(to)). Potassium 95-104 potassium voltage-gated channel subfamily D member 2 Homo sapiens 35-40 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 46-48 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 46-48 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 22-27 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 66-68 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 16-21 20399767-11 2010 The increase of KCNE1/KCNQ1 ratio converted I(Ks) inhibition to I(Ks) activations. Potassium 66-68 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 22-27 20399767-12 2010 One to ten ratio of KCNE1 and KCNQ1 subunit is required for Rg(3) activation of I(Ks). Potassium 82-84 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 20-25 20399767-12 2010 One to ten ratio of KCNE1 and KCNQ1 subunit is required for Rg(3) activation of I(Ks). Potassium 82-84 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 30-35 20399767-15 2010 These results indicate that Rg(3)-induced activation of I(Ks) requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit. Potassium 58-60 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 86-91 20399767-15 2010 These results indicate that Rg(3)-induced activation of I(Ks) requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit. Potassium 58-60 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 96-101 20399767-15 2010 These results indicate that Rg(3)-induced activation of I(Ks) requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit. Potassium 58-60 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 180-185 19874361-2 2010 Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Potassium 68-70 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 138-143 20442363-7 2010 Furthermore, Axl knockdown inhibits KS cell growth and invasion. Potassium 36-38 AXL receptor tyrosine kinase Homo sapiens 13-16 20442363-11 2010 Axl thus has a potential role in KS pathogenesis and is a candidate for prognostic and therapeutic investigations. Potassium 33-35 AXL receptor tyrosine kinase Homo sapiens 0-3 19874361-3 2010 AIM: To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Potassium 64-66 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 38-43 19874361-9 2010 CONCLUSIONS: The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. Potassium 68-70 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 95-100 20444939-0 2010 Adiponectin modulates excitability of rat paraventricular nucleus neurons by differential modulation of potassium currents. Potassium 104-113 adiponectin, C1Q and collagen domain containing Rattus norvegicus 0-11 20444939-9 2010 The results presented in this study suggest that adiponectin controls neuronal excitability through the modulation of different potassium conductances, effects which contribute to changes in excitability and action potential profiles responsible for peptidergic release into the circulation. Potassium 128-137 adiponectin, C1Q and collagen domain containing Rattus norvegicus 49-60 20224560-0 2010 Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Potassium 99-108 apelin Homo sapiens 39-45 20645688-5 2010 Management of the CTCL population requires vigilence to prevent infection with skin contaminants, and monitoring of potassium and magnesium, electrolytes found to be low in a large proportion of patients. Potassium 116-125 TSPY like 2 Homo sapiens 18-22 20348026-1 2010 BACKGROUND: Mutations in the KCNQ1 and human ether-a-go-go-related gene (HERG) genes cause the long QT syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I(Ks) and I(Kr) currents, respectively. Potassium 179-181 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 29-34 20348026-1 2010 BACKGROUND: Mutations in the KCNQ1 and human ether-a-go-go-related gene (HERG) genes cause the long QT syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I(Ks) and I(Kr) currents, respectively. Potassium 179-181 potassium voltage-gated channel subfamily H member 2 Homo sapiens 73-77 20143420-4 2010 We demonstrated that PGC-1alpha expression was down-regulated in cerebellar granule neurons(CGNs) after activation of the JNK/c-Jun pathway by potassium deprivation. Potassium 143-152 PPARG coactivator 1 alpha Homo sapiens 21-31 20143420-4 2010 We demonstrated that PGC-1alpha expression was down-regulated in cerebellar granule neurons(CGNs) after activation of the JNK/c-Jun pathway by potassium deprivation. Potassium 143-152 mitogen-activated protein kinase 8 Homo sapiens 122-125 20143420-4 2010 We demonstrated that PGC-1alpha expression was down-regulated in cerebellar granule neurons(CGNs) after activation of the JNK/c-Jun pathway by potassium deprivation. Potassium 143-152 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 126-131 20143420-5 2010 Overexpression of PGC-1alpha partially protected CGNs from potassium deprivation-induced apoptosis. Potassium 59-68 PPARG coactivator 1 alpha Homo sapiens 18-28 20143420-8 2010 In conclusion, these results suggest that down-expression of PGC-1alpha partially mediated by activation of JNK/c-Jun may be through the binding of c-Jun to the CRE site in the PGC-1alpha promoter, and it might be involved in potassium deprivation-induced apoptosis in CGNs. Potassium 226-235 PPARG coactivator 1 alpha Homo sapiens 61-71 20143420-8 2010 In conclusion, these results suggest that down-expression of PGC-1alpha partially mediated by activation of JNK/c-Jun may be through the binding of c-Jun to the CRE site in the PGC-1alpha promoter, and it might be involved in potassium deprivation-induced apoptosis in CGNs. Potassium 226-235 mitogen-activated protein kinase 8 Homo sapiens 108-111 20143420-8 2010 In conclusion, these results suggest that down-expression of PGC-1alpha partially mediated by activation of JNK/c-Jun may be through the binding of c-Jun to the CRE site in the PGC-1alpha promoter, and it might be involved in potassium deprivation-induced apoptosis in CGNs. Potassium 226-235 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 112-117 20143420-8 2010 In conclusion, these results suggest that down-expression of PGC-1alpha partially mediated by activation of JNK/c-Jun may be through the binding of c-Jun to the CRE site in the PGC-1alpha promoter, and it might be involved in potassium deprivation-induced apoptosis in CGNs. Potassium 226-235 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 148-153 20143421-11 2010 In comparison, another compound, called ASK-2a, that protects cerebellar granule neurons against low-potassium-induced death inhibits GSK3 and p38 MAPK but not CDKs. Potassium 101-110 glycogen synthase kinase 3 beta Mus musculus 134-138 20359524-7 2010 N/OFQ hyperpolarized 25% of RAIC-PAG pyramidal neurons by enhancing inwardly rectifying potassium conductance via pertussis toxin-sensitive G(alphai/o). Potassium 88-97 prepronociceptin Homo sapiens 0-5 20348108-6 2010 Among 100 different growth conditions, those that decrease the membrane potential (high external potassium) or pH gradient (high external pH) caused a reduction in growth of the aha2 mutant compared with wild type. Potassium 97-106 H[+]-ATPase 2 Arabidopsis thaliana 178-182 20412803-1 2010 The phosphatase calcineurin and the kinases Hal4/Hal5 regulate high-affinity potassium uptake in Saccharomyces cerevisiae through the Trk1 transporter. Potassium 77-86 serine/threonine protein kinase SAT4 Saccharomyces cerevisiae S288C 44-48 20412803-1 2010 The phosphatase calcineurin and the kinases Hal4/Hal5 regulate high-affinity potassium uptake in Saccharomyces cerevisiae through the Trk1 transporter. Potassium 77-86 protein kinase HAL5 Saccharomyces cerevisiae S288C 49-53 20412803-1 2010 The phosphatase calcineurin and the kinases Hal4/Hal5 regulate high-affinity potassium uptake in Saccharomyces cerevisiae through the Trk1 transporter. Potassium 77-86 Trk1p Saccharomyces cerevisiae S288C 134-138 20188695-2 2010 Recent studies performed using synthetic p13 and isolated mitochondria demonstrated that the protein triggers an inward potassium (K+) current and inner membrane depolarization. Potassium 120-129 H3 histone pseudogene 6 Homo sapiens 41-44 19913547-2 2010 The co-assembly of the pore-forming human KCNQ1 alpha-subunits with the modulating hKCNE1 beta-subunits generates I(Ks)in vivo, explaining why mutations in the hKCNQ1 gene underlie the LQT1 form of congenital LQT. Potassium 116-118 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 42-47 20224560-0 2010 Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Potassium 99-108 apelin receptor Homo sapiens 46-49 20224560-0 2010 Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Potassium 99-108 angiotensin converting enzyme 2 Homo sapiens 61-65 20224560-2 2010 We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. Potassium 137-146 apelin Homo sapiens 55-61 20224560-2 2010 We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. Potassium 137-146 angiotensin converting enzyme 2 Homo sapiens 77-108 20224560-2 2010 We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. Potassium 137-146 angiotensin converting enzyme 2 Homo sapiens 110-114 20224560-6 2010 RESULTS: In women, SNP rs2235306 in the APLN gene was significantly associated with diastolic BP (DBP) response to potassium supplementation (P = 0.0009). Potassium 115-124 apelin Homo sapiens 40-44 20224560-8 2010 In men, SNP rs4646174 of the ACE2 gene was significantly associated with systolic BP (SBP), DBP, and mean arterial pressure (MAP) responses to potassium supplementation (P = 0.0001, P = 0.001, and P = 3.0 x 10(-6), respectively). Potassium 143-152 angiotensin converting enzyme 2 Homo sapiens 29-33 20224560-10 2010 CONCLUSION: Our study indicates that genetic variation of APLN and ACE2 may influence BP response to potassium intake. Potassium 101-110 apelin Homo sapiens 58-62 20224560-10 2010 CONCLUSION: Our study indicates that genetic variation of APLN and ACE2 may influence BP response to potassium intake. Potassium 101-110 angiotensin converting enzyme 2 Homo sapiens 67-71 20421639-10 2010 Furthermore, our results suggest that the lysosomal cathepsin B protease, the formation of reactive oxygen species, and the efflux of potassium are needed for beta-glucan-induced NLRP3 inflammasome activation. Potassium 134-143 NLR family pyrin domain containing 3 Homo sapiens 179-184 20051248-1 2010 Recent evidence shows that the auxiliary subunit KChIP2, which assembles with pore-forming Kv4-subunits, represents a new potential regulator of the cardiac calcium-independent transient outward potassium current (I(to)) density. Potassium 195-204 potassium voltage-gated channel interacting protein 2 Rattus norvegicus 49-55 19913547-2 2010 The co-assembly of the pore-forming human KCNQ1 alpha-subunits with the modulating hKCNE1 beta-subunits generates I(Ks)in vivo, explaining why mutations in the hKCNQ1 gene underlie the LQT1 form of congenital LQT. Potassium 116-118 putative potassium voltage-gated channel subfamily E member 1B Homo sapiens 83-94 19913547-2 2010 The co-assembly of the pore-forming human KCNQ1 alpha-subunits with the modulating hKCNE1 beta-subunits generates I(Ks)in vivo, explaining why mutations in the hKCNQ1 gene underlie the LQT1 form of congenital LQT. Potassium 116-118 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 160-166 19913547-2 2010 The co-assembly of the pore-forming human KCNQ1 alpha-subunits with the modulating hKCNE1 beta-subunits generates I(Ks)in vivo, explaining why mutations in the hKCNQ1 gene underlie the LQT1 form of congenital LQT. Potassium 116-118 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 185-189 19913547-4 2010 Mutant subunits with this arginine substitution generated no or barely detectable currents in a homotetrameric condition, but did generate I(Ks)-like currents in association with hKCNE1. Potassium 141-143 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 179-185 20413648-0 2010 High-affinity K(+) transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Potassium 135-144 high affinity K+ transporter 5 Arabidopsis thaliana 45-51 20357072-0 2010 Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents. Potassium 124-133 nitric oxide synthase, brain Oryctolagus cuniculus 14-44 20413648-0 2010 High-affinity K(+) transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Potassium 135-144 K+ transporter 1 Arabidopsis thaliana 56-60 20346391-6 2010 CCL2 significantly lowered the net whole-cell potassium currents in neurons after CCD but not after CCI or SNL. Potassium 46-55 C-C motif chemokine ligand 2 Rattus norvegicus 0-4 20354865-5 2010 Using transfected Chinese hamster ovary (CHO) cells to reconstitute Kv4 complex, we show that the pharmacological inhibition of DPP10 glycosylation by tunicamycin and neuraminidase affects transient outward potassium current (I (to)) kinetics. Potassium 207-216 inactive dipeptidyl peptidase 10 Cricetulus griseus 128-133 20303341-0 2010 Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus. Potassium 91-100 carbonic anhydrase 3 Rattus norvegicus 30-33 20377177-1 2010 Two-dimensional magic angle flipping (MAF) was employed to measure the Q((n)) distribution in a (29)Si-enriched potassium disilicate glass (K(2)O.2SiO(2)). Potassium 112-121 MAF bZIP transcription factor Homo sapiens 38-41 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 92-94 prostaglandin E receptor 1 Homo sapiens 51-54 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 92-94 prostaglandin E receptor 2 Homo sapiens 56-59 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 92-94 prostaglandin E receptor 3 Homo sapiens 61-64 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 92-94 prostaglandin E receptor 4 Homo sapiens 70-73 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 144-146 prostaglandin E receptor 2 Homo sapiens 133-136 20388794-3 2010 Microsomal PGE2 synthase, PGE2, and its receptors (EP1, EP2, EP3, and EP4) were detected in KS lesions with the distinct staining of EP2/EP4 in KS lesions. Potassium 144-146 prostaglandin E receptor 4 Homo sapiens 137-140 20056717-7 2010 The anti-miR-204-induced decrease in Kir7.1 protein levels suggests a signaling pathway that connects TGF-betaR2 and maintenance of potassium homeostasis. Potassium 132-141 microRNA 204 Homo sapiens 9-16 20056717-7 2010 The anti-miR-204-induced decrease in Kir7.1 protein levels suggests a signaling pathway that connects TGF-betaR2 and maintenance of potassium homeostasis. Potassium 132-141 potassium inwardly rectifying channel subfamily J member 13 Homo sapiens 37-43 20229012-5 2010 hERG channels were expressed in Xenopus laevis oocytes and HEK 293 cells, and potassium currents were recorded using patch clamp and two-electrode voltage clamp electrophysiology. Potassium 78-87 ETS transcription factor ERG Homo sapiens 0-4 20392939-3 2010 To test whether Kv1.1-potassium deficiency could underlie primary neurogenic cardiac dysfunction, we performed simultaneous video EEG-ECG recordings and found that Kcna1-null mice display potentially malignant interictal cardiac abnormalities, including a fivefold increase in atrioventricular (AV) conduction blocks, as well as bradycardia and premature ventricular contractions. Potassium 22-31 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 16-21 20421371-8 2010 We conclude that S3 mutants of KCNQ1 cause LQTS predominantly through biophysical effects on the gating of I(Ks), but some mutants also show protein stability/trafficking defects, which explains why the kinetic gain-of-function mutation S209F causes LQT1. Potassium 109-111 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 31-36 20392939-3 2010 To test whether Kv1.1-potassium deficiency could underlie primary neurogenic cardiac dysfunction, we performed simultaneous video EEG-ECG recordings and found that Kcna1-null mice display potentially malignant interictal cardiac abnormalities, including a fivefold increase in atrioventricular (AV) conduction blocks, as well as bradycardia and premature ventricular contractions. Potassium 22-31 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 164-169 20375134-1 2010 During neuronal activity astrocytes function to remove extracellular increases in potassium, which are largely mediated by the inwardly-rectifying potassium channel Kir4.1, and to take up excess glutamate via glutamate transporter 1, a glial-specific glutamate transporter. Potassium 82-91 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 165-171 20089930-0 2010 Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. Potassium 88-97 angiotensinogen Homo sapiens 42-56 20375134-9 2010 These findings suggest that the neuroprotective benefits previously seen with 17beta-oestradiol after spinal cord injury may be in part due to increased Kir4.1 and glutamate transporter 1 expression in astrocytes leading to improved potassium and glutamate homeostasis. Potassium 233-242 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus 153-159 20132223-7 2010 Among various coactivators for PPARalpha, only steroid receptor coactivator (SRC)-3 level was higher in the KS-type. Potassium 108-110 peroxisome proliferator activated receptor alpha Rattus norvegicus 31-40 20132223-10 2010 EMSA supported the binding of these proteins to PPARalpha associated to the BE enhancer in CF-treated KS-type, but not in the NC-type. Potassium 102-104 peroxisome proliferator activated receptor alpha Rattus norvegicus 48-57 19996987-0 2010 Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese. Potassium 27-36 endothelin 1 Homo sapiens 93-105 19996987-0 2010 Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese. Potassium 27-36 selectin E Homo sapiens 130-138 19996987-7 2010 RESULTS: Single SNP analysis identified significant associations for several SNPs in EDN1 with multiple measures of BP response to potassium supplementation. Potassium 131-140 endothelin 1 Homo sapiens 85-89 19996987-10 2010 CONCLUSION: Our results implicate variability in EDN1 and SELE as genetic factors that influence BP response to potassium intake. Potassium 112-121 endothelin 1 Homo sapiens 49-53 19996987-10 2010 CONCLUSION: Our results implicate variability in EDN1 and SELE as genetic factors that influence BP response to potassium intake. Potassium 112-121 selectin E Homo sapiens 58-62 19996987-11 2010 Although such epidemiological studies do not allow direct determination of physiologic mechanisms, our findings of joint effects identify EDN1 and SELE as targets for functional studies to determine their interactions in BP response to potassium intake. Potassium 236-245 endothelin 1 Homo sapiens 138-142 20583536-1 2010 Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Potassium 139-148 nuclear receptor subfamily 3 group C member 2 Homo sapiens 175-201 20299355-8 2010 Paradoxically, this led to increased urinary fluid velocity in potassium-adapted Kcnmb4-deficient mice compared with wild-type mice. Potassium 63-72 potassium large conductance calcium-activated channel, subfamily M, beta member 4 Mus musculus 81-87 20583536-1 2010 Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Potassium 139-148 nuclear receptor subfamily 3 group C member 2 Homo sapiens 203-205 20003076-0 2010 Glucagon-like peptide-1 inhibits voltage-gated potassium currents in mouse nodose ganglion neurons. Potassium 47-56 glucagon Mus musculus 0-23 20436212-7 2010 Under AP clamp, peak repolarising current was significantly augmented for V307L KCNQ1 compared to WT KCNQ1 for both ventricular and atrial AP commands, consistent with an ability of the V307L mutation to increase repolarising I(Ks) in both regions. Potassium 228-230 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 80-85 20003076-10 2010 We identified a GLP-1 sensitive current whose reversal potential shifted in a depolarizing direction when extracellular potassium was increased. Potassium 120-129 glucagon Mus musculus 16-21 20003076-14 2010 CONCLUSIONS & INFERENCES: These experiments indicate that GLP-1 receptor activation results in vagal afferent excitation, due at least in part to inhibition of sustained and inactivating potassium currents. Potassium 191-200 glucagon-like peptide 1 receptor Mus musculus 62-76 20074622-0 2010 Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia. Potassium 20-29 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 38-44 20170697-1 2010 Depolarization of cultured mouse cerebellar granule cells with potassium or kainate results in developmentally arrested state that includes down-regulation of GABA(A) receptor alpha1, alpha6 and beta2 subunit expression. Potassium 63-72 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 Mus musculus 184-190 20170697-1 2010 Depolarization of cultured mouse cerebellar granule cells with potassium or kainate results in developmentally arrested state that includes down-regulation of GABA(A) receptor alpha1, alpha6 and beta2 subunit expression. Potassium 63-72 hemoglobin, beta adult minor chain Mus musculus 195-200 19902272-4 2010 Tissue-specific alterations of growth hormone and insulin-like growth factor I axis have been described in experimental models of potassium depletion. Potassium 130-139 growth hormone 1 Homo sapiens 31-45 19902272-4 2010 Tissue-specific alterations of growth hormone and insulin-like growth factor I axis have been described in experimental models of potassium depletion. Potassium 130-139 insulin-like growth factor 1 Rattus norvegicus 50-78 19903464-0 2010 Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652. Potassium 34-43 ETS transcription factor ERG Homo sapiens 29-33 20100173-4 2010 We found that xCT was overexpressed in KS tissues and HHV-8-positive BCBL-1 cells. Potassium 39-41 solute carrier family 7 member 11 Homo sapiens 14-17 20100173-7 2010 These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation. Potassium 73-75 solute carrier family 7 member 11 Homo sapiens 66-69 20344995-5 2010 For NDI, the potassium sparing diuretic amiloride or a thiazide diuretic can improve polyuria. Potassium 13-22 arginine vasopressin receptor 2 Homo sapiens 4-7 20369755-9 2010 Some authors still recommend glucose-potassium-insulin infusions for all patients with type 1 diabetes. Potassium 37-46 insulin Homo sapiens 47-54 19277489-5 2010 In freshly isolated hippocampal pyramidal neurons, 54.25% of potassium current was inhibited by 20 microg/ml Gln49-PLA(2). Potassium 61-70 phospholipase A2, group V Mus musculus 115-120 20139709-5 2010 In this study we used a novel approach to demonstrate that purified recombinant human KCNE1 protein (prKCNE1) modulates KCNQ1 channels heterologously expressed in Xenopus oocytes resulting in generation of I(Ks). Potassium 208-210 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 86-91 20139709-5 2010 In this study we used a novel approach to demonstrate that purified recombinant human KCNE1 protein (prKCNE1) modulates KCNQ1 channels heterologously expressed in Xenopus oocytes resulting in generation of I(Ks). Potassium 208-210 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 120-125 19845787-5 2010 Physiological fluctuations of all NKAT regulators in blood, many known to be involved in migraine, are monitored by receptors on the luminal wall of brain CECs; signals are then transduced to their abluminal NKATs that alter brain extracellular sodium ([Na(+)](e)) and potassium ([K(+)](e)). Potassium 269-278 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Homo sapiens 34-38 20185111-2 2010 Genetic variants in the KCNE1 gene, encoding for the beta-subunit (minK) of a slowly activated cardiac potassium channel (I(ks)), may impair myocardial repolarization. Potassium 124-126 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 24-29 20052569-9 2010 SMC obtained from irradiated rats treated with hMSC demonstrated a significantly increased paxilline-sensitive component of outward potassium currents, indicating that BK(Ca) activity had been restored. Potassium 132-141 musculin Homo sapiens 47-51 20139158-0 2010 A peroxidase contributes to ROS production during Arabidopsis root response to potassium deficiency. Potassium 79-88 peroxidase Arabidopsis thaliana 2-12 20139158-1 2010 Reactive oxygen species (ROS) play an important role in root responses to potassium deprivation by regulating the expression of the high-affinity K(+) transporter gene AtHAK5 and other genes. Potassium 74-83 high affinity K+ transporter 5 Arabidopsis thaliana 168-174 20139158-4 2010 RCI3 was found to be up-regulated upon potassium deprivation. Potassium 39-48 Peroxidase superfamily protein Arabidopsis thaliana 0-4 20139158-6 2010 These results suggested that RCI3 is involved in the production of ROS under potassium deprivation and that RCI3-mediated ROS production affects the regulation of AtHAK5 expression. Potassium 77-86 Peroxidase superfamily protein Arabidopsis thaliana 29-33 20139158-7 2010 This peroxidase appears to be another component of the low-potassium signal transduction pathway in Arabidopsis roots. Potassium 59-68 peroxidase Arabidopsis thaliana 5-15 20339157-0 2010 Coronatine-insensitive 1 (COI1) mediates transcriptional responses of Arabidopsis thaliana to external potassium supply. Potassium 103-112 RNI-like superfamily protein Arabidopsis thaliana 0-24 20339157-0 2010 Coronatine-insensitive 1 (COI1) mediates transcriptional responses of Arabidopsis thaliana to external potassium supply. Potassium 103-112 RNI-like superfamily protein Arabidopsis thaliana 26-30 20390067-4 2010 Loss-of-function mutations in KCNH2, the gene encoding the cardiac ion channel that is responsible for the rapidly activating delayed rectifying potassium current, are linked to long-QT syndrome type 2 (LQT-2). Potassium 145-154 potassium voltage-gated channel subfamily H member 2 Homo sapiens 30-35 20390067-4 2010 Loss-of-function mutations in KCNH2, the gene encoding the cardiac ion channel that is responsible for the rapidly activating delayed rectifying potassium current, are linked to long-QT syndrome type 2 (LQT-2). Potassium 145-154 potassium voltage-gated channel subfamily H member 2 Homo sapiens 203-208 20112435-2 2010 But physicians" concerns about the risk of hyperkalemia (elevated serum potassium level), a potentially fatal adverse effect, may limit optimal management with ACE-inhibitors. Potassium 72-81 angiotensin I converting enzyme Homo sapiens 160-163 19895883-0 2010 Effect of melamine on potassium currents in rat hippocampal CA1 neurons. Potassium 22-31 carbonic anhydrase 1 Rattus norvegicus 60-63 20029090-11 2010 Therefore, it is likely that potassium is the predominant MVC bound to HDAC8 in vivo. Potassium 29-38 histone deacetylase 8 Homo sapiens 71-76 19907016-1 2010 KCNE1 associates with the pore-forming alpha-subunit KCNQ1 to generate the slow (I(Ks)) current in cardiac myocytes. Potassium 83-85 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 0-5 19907016-1 2010 KCNE1 associates with the pore-forming alpha-subunit KCNQ1 to generate the slow (I(Ks)) current in cardiac myocytes. Potassium 83-85 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 53-58 19907016-3 2010 We previously investigated a mutation in KCNE1, T58P/L59P, which causes severe attenuation of I(Ks). Potassium 96-98 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 41-46 19437409-6 2010 However, release of glutamate and acetylcholine was decreased from the hippocampus in response to high-potassium treatment in the Cyp D(-/-) mice than in the wild-type mice. Potassium 103-112 peptidylprolyl isomerase F (cyclophilin F) Mus musculus 130-135 20043893-0 2010 Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Potassium 92-101 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 122-129 20043893-3 2010 In the present study, the effect of bis(7)-tacrine was investigated on the K(V)4.2 encoded potassium currents expressed in Xenopus oocytes and the transient A-type potassium current (I(K(A))) on rat DRG neurons. Potassium 91-100 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 75-82