PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15177439-0	2004	Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.	Pyrans	0-5	matrix metallopeptidase 1	Homo sapiens	54-57
15177439-0	2004	Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.	Pyrans	0-5	matrix metallopeptidase 1	Homo sapiens	80-85
12699762-1	2003	In our effort to develop novel molecules for the dopamine transporter, we converted our previously designed dopamine transporter specific 3,6-disubstituted piperidine template into corresponding pyran derivatives.	Pyrans	195-200	solute carrier family 6 member 3	Homo sapiens	49-69
12699762-1	2003	In our effort to develop novel molecules for the dopamine transporter, we converted our previously designed dopamine transporter specific 3,6-disubstituted piperidine template into corresponding pyran derivatives.	Pyrans	195-200	solute carrier family 6 member 3	Homo sapiens	108-128
217345-2	1978	Four pyrans of various molecular weights more potently inhibited terminal deoxyribonucleotidyltransferase (EC 2.7.7.31) from a human cell line of acute lymphoblastic leukemia origin (Molt-4) than they did DNA polymerases alpha, beta and gamma from these cells and DNA polymerase from simian sarcoma virus.	Pyrans	5-11	DNA nucleotidylexotransferase	Homo sapiens	65-105
11360686-9	2000	The pyran cycle and the aminium group of TAK779 interact with residues in the binding pocket of CCR5 receptor, the other part of TAK779 interacts with residues from the extracellular loops of CCR5.	Pyrans	4-9	C-C motif chemokine receptor 5	Homo sapiens	96-100
12391577-3	2002	The [H3O] loss proceeds via loss of water to form a pyran ion, which subsequently eliminates a hydrogen atom to form the stable pyrillium cation.	Pyrans	52-57	H3 clustered histone 15	Homo sapiens	5-8
10755463-5	2000	We found that isoflavonoids and compounds which presented the phenolic B ring in the 3 position on the pyran ring preferentially inhibited 3beta-HSD and/or 17beta-HSD activities than aromatase activity.	Pyrans	103-108	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	139-148
10755463-5	2000	We found that isoflavonoids and compounds which presented the phenolic B ring in the 3 position on the pyran ring preferentially inhibited 3beta-HSD and/or 17beta-HSD activities than aromatase activity.	Pyrans	103-108	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	156-166
2998590-4	1985	Pyran copolymer-induced peritoneal cells endowed the tumour vaccine-primed mice, but not unprimed mice, with resistance to implanted L1210 and, among those peritoneal cell populations, macrophages but not T cells were responsible for this effect since the activity was associated with a cell population which was adherent to nylon wool columns, sensitive to silica and insensitive to anti-Thy 1.2 antibody plus complement.	Pyrans	0-5	thymus cell antigen 1, theta	Mus musculus	389-396
217345-2	1978	Four pyrans of various molecular weights more potently inhibited terminal deoxyribonucleotidyltransferase (EC 2.7.7.31) from a human cell line of acute lymphoblastic leukemia origin (Molt-4) than they did DNA polymerases alpha, beta and gamma from these cells and DNA polymerase from simian sarcoma virus.	Pyrans	5-11	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	205-226
217345-3	1978	For example, the concentrations of one pyran required for 50% inhibition of terminal deoxynucleotidyltransferase, DNA polymerases alpha, beta and gamma and viral DNA polymerase were 0.9, 110, 125, 35 and 47 microgram/ml respectively.	Pyrans	39-44	DNA nucleotidylexotransferase	Homo sapiens	76-112
217345-3	1978	For example, the concentrations of one pyran required for 50% inhibition of terminal deoxynucleotidyltransferase, DNA polymerases alpha, beta and gamma and viral DNA polymerase were 0.9, 110, 125, 35 and 47 microgram/ml respectively.	Pyrans	39-44	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	114-135
33225729-8	2020	Conclusion: Tropane/pyran scaffold can be considered as a promising core for anticancer agents acting as CDK2 inhibitors.	Pyrans	20-25	cyclin dependent kinase 2	Homo sapiens	105-109
1268825-7	1976	Pyran slightly activated macrophages from nonsensitized mice to become cytotoxic for MBL-2 cells; activation was not T-cell dependent.	Pyrans	0-5	mannose-binding lectin (protein C) 2	Mus musculus	85-90
33438568-0	2021	Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, AntiProliferative Activities.	Pyrans	70-75	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	127-132
32087383-5	2020	Na+ had attraction with O atoms (alpha: O6; beta: O6 and O1), with the outflow of electron from C atom to O atom on the C1-O6 bond, which was beneficial to the transformation between chain form and pyran forms.	Pyrans	198-203	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	33-59
31588297-5	2019	Theoretical studies demonstrate that the incorporation of a heteroatom at the meso-position enables more effective pi-extension, resulting in a 22pi aromatic (vs. 18pi aromatic) character of pyran-fused porphyrins (syn/anti-5aa).	Pyrans	191-196	synemin	Homo sapiens	215-218
32209043-7	2020	The simplest analog 27 contains only one pyran, which is also able to modulate the PKCalpha activity, however the cyclic framework appears to be essential for desired potency.	Pyrans	41-46	protein kinase C, alpha	Mus musculus	83-91
27227655-2	2016	High structural and stereochemical diversity of these pyran fused NH-azridine scaffolds makes them useful in evaluating their biological and pharmacological activities by SAR studies.	Pyrans	54-59	sarcosine dehydrogenase	Homo sapiens	171-174
30006156-5	2018	Moreover, molecular dynamics simulations demonstrated that both benzofuran and pyran moieties are requisite to fit into the active site of BMP-2 receptor, a key target of the osteogenic agents.	Pyrans	79-84	bone morphogenetic protein 2	Rattus norvegicus	139-144
28013183-1	2017	In this work, novel series of pyran, thiophene and thienopyrimidine derivatives based on 2-acetamide-thiadiazole scaffold were designed and synthesized for evaluation as selective COX-2 inhibitors in-vitro and investigated in-vivo as anti-inflammatory and analgesic agents against carrageenan-induced rat paw oedema model in irradiated rats, since its well-known that ionizing radiation plays an important role in exaggerating the inflammatory responses and in enhancing the release of inflammatory mediators in experimental animals.	Pyrans	30-35	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	180-185
25593099-4	2015	In this report, we have described an SAR study on our pyran-based triple reuptake inhibitors (TRIs) which are being investigated as the next-generation antidepressants.	Pyrans	54-59	sarcosine dehydrogenase	Homo sapiens	37-40
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Pyrans	172-177	sulfite oxidase	Homo sapiens	19-23
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Pyrans	172-177	sulfite oxidase	Homo sapiens	216-220
25328243-2	2013	The pyran thiolone, 3a, was synthesized by chlorination of 3,4-dihydro-2H-pyran (1), followed by condensing with CS2 and NaSH.	Pyrans	4-9	chorionic somatomammotropin hormone 2	Homo sapiens	113-116
22044003-0	2012	Synthesis of Cis-fused pyran indolocarbazole derivatives that inhibit FLT3 kinase and the DNA damage kinase, checkpoint kinase 1.	Pyrans	23-28	fms related receptor tyrosine kinase 3	Homo sapiens	70-74
22961965-0	2012	Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway.	Pyrans	0-5	peptidylprolyl isomerase G	Homo sapiens	31-34
22044003-0	2012	Synthesis of Cis-fused pyran indolocarbazole derivatives that inhibit FLT3 kinase and the DNA damage kinase, checkpoint kinase 1.	Pyrans	23-28	checkpoint kinase 1	Homo sapiens	109-128
18271514-4	2008	Diversification of the oxepines and pyrans involved conversion of the methyl carboxylate group to a carboxamide via either a microwave-assisted amidation using polymer-bound carbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) or a NaCN-catalyzed aminolysis.	Pyrans	36-42	DCC netrin 1 receptor	Homo sapiens	188-191
19762008-3	2009	Crystals of 2 are monoclinic, with space group P2(1), the cyclopentane and pyran rings also adopt the envelope conformation.	Pyrans	75-80	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-52
18561912-0	2008	D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action.	Pyrans	15-20	solute carrier family 18 member A2	Rattus norvegicus	34-55
18561912-9	2008	These results suggest that the novel asymmetric pyran derivative D-161 with unique molecular structure exhibiting triple monoamine transporter inhibitory activity could possess potent antidepressant activity.	Pyrans	48-53	solute carrier family 18 member A2	Rattus norvegicus	121-142
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM < IC50 < 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Pyrans	64-69	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	190-193
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM < IC50 < 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Pyrans	64-69	hemoglobin subunit alpha 1	Homo sapiens	195-199
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM < IC50 < 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Pyrans	64-69	complement C2	Homo sapiens	205-208
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM < IC50 < 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Pyrans	64-69	hemoglobin subunit alpha 2	Homo sapiens	210-214
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM < IC50 < 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Pyrans	64-69	hemoglobin subunit alpha pseudogene 1	Homo sapiens	285-289
16330864-4	2005	In both molecules, the methoxy group of the pseudo-axial aryl substituent is syn with respect to the pyran ring.	Pyrans	101-106	synemin	Homo sapiens	77-80
17599282-6	2007	In terms of structural requirements for UGT1A1 induction, the present study suggests that the B-ring (phenyl) for chrysin and the furan or pyran rings for coumarins are essential for the biological activity.	Pyrans	139-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46