PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30735036-8 2019 We also identified candidate regulatory genes similar to WRI1 and DGAT1 in Arabidopsis that may be involved in the regulation of tocopherol biosynthesis. Tocopherols 129-139 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 57-61 30735036-8 2019 We also identified candidate regulatory genes similar to WRI1 and DGAT1 in Arabidopsis that may be involved in the regulation of tocopherol biosynthesis. Tocopherols 129-139 membrane bound O-acyl transferase (MBOAT) family protein Arabidopsis thaliana 66-71 30753245-7 2019 In this study, we investigated how SlGLK2 is regulated by light, auxin and cytokinin and determined the effect of SlGLK2 on tocopherol (vitamin E) and sugar metabolism, which are components of the fruit nutritional and industrial quality. Tocopherols 124-134 transcription factor GLK2 Solanum lycopersicum 114-120 30753245-11 2019 Additionally, SlGLK2 enhanced chlorophyll content in immature green fruits, leading to an increment in tocopherol level in ripe fruits. Tocopherols 103-113 transcription factor GLK2 Solanum lycopersicum 14-20 30541876-7 2019 Metabolites of the sterol, tocopherol, quinone, and sugar classes are differentially accumulated in cry1a and cry2 leaves and fruits. Tocopherols 27-37 cryptochrome 1 Solanum lycopersicum 100-105 30541876-7 2019 Metabolites of the sterol, tocopherol, quinone, and sugar classes are differentially accumulated in cry1a and cry2 leaves and fruits. Tocopherols 27-37 cryptochrome 2 Arabidopsis thaliana 110-114 30034989-1 2018 gamma-Tocopherol methyl transferase (gamma-TMT) (EC 2.1.1.95) is the key enzyme of the tocopherol biosynthetic pathway that determines the alpha-tocopherol concentration in plants. Tocopherols 87-97 gamma-tocopherol methyltransferase Glycine max 0-35 30244813-0 2018 Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Tocopherols 0-10 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 84-90 29601642-1 2018 The Arabidopsis vte1 mutant is devoid of tocopherol and plastochromanol (PC-8). Tocopherols 41-51 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 16-20 29601642-3 2018 Here, we show that overexpressing the solanesyl diphosphate synthase 1 (SPS1) gene in vte1 induced a marked accumulation of total plastoquinone (PQ-9) and rendered the vte1 SPS1oex plants tolerant to photooxidative stress, indicating that PQ-9 can replace tocopherol and PC-8 in photoprotection. Tocopherols 256-266 solanesyl diphosphate synthase 1 Arabidopsis thaliana 38-70 29601642-3 2018 Here, we show that overexpressing the solanesyl diphosphate synthase 1 (SPS1) gene in vte1 induced a marked accumulation of total plastoquinone (PQ-9) and rendered the vte1 SPS1oex plants tolerant to photooxidative stress, indicating that PQ-9 can replace tocopherol and PC-8 in photoprotection. Tocopherols 256-266 solanesyl diphosphate synthase 1 Arabidopsis thaliana 72-76 29601642-3 2018 Here, we show that overexpressing the solanesyl diphosphate synthase 1 (SPS1) gene in vte1 induced a marked accumulation of total plastoquinone (PQ-9) and rendered the vte1 SPS1oex plants tolerant to photooxidative stress, indicating that PQ-9 can replace tocopherol and PC-8 in photoprotection. Tocopherols 256-266 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 86-90 29601642-3 2018 Here, we show that overexpressing the solanesyl diphosphate synthase 1 (SPS1) gene in vte1 induced a marked accumulation of total plastoquinone (PQ-9) and rendered the vte1 SPS1oex plants tolerant to photooxidative stress, indicating that PQ-9 can replace tocopherol and PC-8 in photoprotection. Tocopherols 256-266 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 168-172 30034989-1 2018 gamma-Tocopherol methyl transferase (gamma-TMT) (EC 2.1.1.95) is the key enzyme of the tocopherol biosynthetic pathway that determines the alpha-tocopherol concentration in plants. Tocopherols 87-97 gamma-tocopherol methyltransferase Glycine max 37-46 29885892-4 2018 The method was able to detect the expected declines in tocopherols in milk exposed to UHT or skimming treatments. Tocopherols 55-66 UHT Bos taurus 86-89 29846560-0 2018 Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer. Tocopherols 0-11 POU class 5 homeobox 1 Homo sapiens 57-61 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 POU class 5 homeobox 1 Homo sapiens 65-69 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 CD44 molecule (Indian blood group) Homo sapiens 71-75 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 SRY-box transcription factor 2 Homo sapiens 80-85 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 trefoil factor 1 Homo sapiens 136-139 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 progesterone receptor Homo sapiens 147-150 29846560-8 2018 Tocopherols decreased the levels of stem cell markers, including OCT4, CD44 and SOX-2, as well as estrogen-related markers, such as TFF/pS2, CTSD, PGR and SERPINA1, in estrogen-stimulated tumorspheres. Tocopherols 0-11 serpin family A member 1 Homo sapiens 155-163 29846560-9 2018 Overexpression of OCT4 increased CD44 and SOX2 levels and significantly increased cell invasion and expression of the invasion markers, matrix metalloproteinases, tissue inhibitors of metalloproteinase and urokinase plasminogen activator, and tocopherols inhibited these OCT4-mediated effects. Tocopherols 243-254 POU class 5 homeobox 1 Homo sapiens 18-22 29731975-1 2018 Plasma phospholipid transfer protein (PLTP) binds and transfers a number of amphipathic compounds, including phospholipids, cholesterol, diacylglycerides, tocopherols and lipopolysaccharides. Tocopherols 155-166 phospholipid transfer protein Mus musculus 7-36 29662196-0 2018 Tocopherols inhibit esophageal carcinogenesis through attenuating NF-kappaB activation and CXCR3-mediated inflammation. Tocopherols 0-11 chemokine (C-X-C motif) receptor 3 Mus musculus 91-96 29662196-3 2018 Here we report that dietary tocopherols significantly prevents esophageal carcinogenesis by inhibiting the activation of NF-kappaB and the subsequent interaction of chemokine CXCL9/10/11 with their receptor CXCR3 in ESCC induced by N-nitrosomethylbenzylamine (NMBA) in murine models. Tocopherols 28-39 chemokine (C-X-C motif) ligand 9 Mus musculus 175-180 29662196-3 2018 Here we report that dietary tocopherols significantly prevents esophageal carcinogenesis by inhibiting the activation of NF-kappaB and the subsequent interaction of chemokine CXCL9/10/11 with their receptor CXCR3 in ESCC induced by N-nitrosomethylbenzylamine (NMBA) in murine models. Tocopherols 28-39 chemokine (C-X-C motif) receptor 3 Mus musculus 207-212 29662196-6 2018 Our results show that tocopherols decrease carcinogenesis through inhibiting NF-kappaB and CXCR3 signaling, as well as related inflammation in early premalignant lesions. Tocopherols 22-33 chemokine (C-X-C motif) receptor 3 Mus musculus 91-96 29102450-2 2018 Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Tocopherols 179-189 scavenger receptor class B member 1 Homo sapiens 39-44 29526809-5 2018 RNA-sequencing of the spinal cord in Ttpa-/- mice revealed upregulation of genes associated with the innate immune response, indicating a molecular signature of microglial activation as a result of tocopherol deficiency. Tocopherols 198-208 tocopherol (alpha) transfer protein Mus musculus 37-41 29623327-2 2018 To address this and based on earlier encouraging results using tocopherol cationic lipids, we elaborated chemical modifications on tocopherol cationic lipids by introducing a novel hybrid pH sensitive linker "ether-beta-hydroxy-triazole" between tocopherol, the anchoring moiety and the basic tris(2-hydroxy ethyl)quaternary ammonium head group (Lp2). Tocopherols 131-141 ribosomal protein lateral stalk subunit P2 Homo sapiens 346-349 29623327-2 2018 To address this and based on earlier encouraging results using tocopherol cationic lipids, we elaborated chemical modifications on tocopherol cationic lipids by introducing a novel hybrid pH sensitive linker "ether-beta-hydroxy-triazole" between tocopherol, the anchoring moiety and the basic tris(2-hydroxy ethyl)quaternary ammonium head group (Lp2). Tocopherols 131-141 ribosomal protein lateral stalk subunit P2 Homo sapiens 346-349 29731975-1 2018 Plasma phospholipid transfer protein (PLTP) binds and transfers a number of amphipathic compounds, including phospholipids, cholesterol, diacylglycerides, tocopherols and lipopolysaccharides. Tocopherols 155-166 phospholipid transfer protein Mus musculus 38-42 27016075-5 2016 Both 13"-COOHs are much stronger than tocopherols in inhibition of pro-inflammatory and cancer promoting cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), and in induction of apoptosis and autophagy in colon cancer cells. Tocopherols 38-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 105-121 29606742-9 2018 Additionally, an alcoholic wine extract (100 mug/mL) led to a 40.31% decrease in iNOS expression in LPS-stimulated cells, which was more effective than the same dose of tocopherol. Tocopherols 169-179 nitric oxide synthase 2, inducible Mus musculus 81-85 29196050-9 2018 Tocopherol (10-7M) itself can induce the cyclooxygenase activity and shift the COX-1 and COX-2 ratio to COX-2. Tocopherols 0-10 cytochrome c oxidase II, mitochondrial Rattus norvegicus 104-109 29196050-12 2018 Tocopherol has a tissue specific COX-2 activity increasing effect in pregnant rat uterus but has no such action in non-pregnant uteri or tracheal tissue. Tocopherols 0-10 cytochrome c oxidase II, mitochondrial Rattus norvegicus 33-38 29196050-13 2018 Hereby, tocopherol may intensify selectively the uterine relaxing effect of COX-2 inhibitors in preterm contractions. Tocopherols 8-18 cytochrome c oxidase II, mitochondrial Rattus norvegicus 76-81 30592875-10 2018 The results of the work indicate the possibility of 13"-carboxychromanols to competitively bind to alpha-tocopherol transporters and act as effective ligands of COX-2 and HMG-CoA, that can be used to correct nutritional status in conditions accompanied by deficiency of tocopherols. Tocopherols 270-281 prostaglandin-endoperoxide synthase 2 Homo sapiens 161-166 28811265-1 2017 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is the last enzyme in the tocopherol biosynthetic pathway and it catalyzes the conversion of gamma-tocopherol into alpha-tocopherol, the nutritionally significant and most bioactive form of vitamin E. Tocopherols 87-97 gamma-tocopherol methyltransferase Glycine max 0-34 28811265-1 2017 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is the last enzyme in the tocopherol biosynthetic pathway and it catalyzes the conversion of gamma-tocopherol into alpha-tocopherol, the nutritionally significant and most bioactive form of vitamin E. Tocopherols 87-97 gamma-tocopherol methyltransferase Glycine max 36-45 28811265-1 2017 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is the last enzyme in the tocopherol biosynthetic pathway and it catalyzes the conversion of gamma-tocopherol into alpha-tocopherol, the nutritionally significant and most bioactive form of vitamin E. Tocopherols 159-170 gamma-tocopherol methyltransferase Glycine max 0-34 28811265-1 2017 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is the last enzyme in the tocopherol biosynthetic pathway and it catalyzes the conversion of gamma-tocopherol into alpha-tocopherol, the nutritionally significant and most bioactive form of vitamin E. Tocopherols 159-170 gamma-tocopherol methyltransferase Glycine max 36-45 28397308-10 2017 CONCLUSIONS: Our results indicated that supplemented serum-free medium with tocopherol and IBMX enhances viability and PDX1 gene expression compared to serum-added and serum-free media. Tocopherols 76-86 pancreatic and duodenal homeobox 1 Homo sapiens 119-123 28165404-3 2017 Structurally, tocopherols and tocotrienols share a similar chromanol ring and a side chain at the C-2 position. Tocopherols 14-25 complement C2 Homo sapiens 98-101 28637410-2 2017 Hence, it is imperative to design novel HPPD inhibitors that can block HPPA-HGA conversion, which leads to the deficiency in isoprenoid redox cofactors such as plastoquinone and tocopherol, and finally caused growth inhibition. Tocopherols 178-188 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 40-44 30645867-5 2017 Deficiency of vitamins B2, A and E, when blood serum concentrations of riboflavin <5 ng/ml, retinol <30 mug/dL and tocopherols <0.8 mg/dL, were found in 34, 15 and 13% of participants, respectively. Tocopherols 121-132 immunoglobulin kappa variable 5-2 Homo sapiens 23-34 27548849-4 2016 METHODS: We used our newly developed enzyme-linked immunosorbent assay systems for measuring different forms of alpha-synuclein, such as oligomeric-alpha-synuclein, phosphorylated-alpha-synuclein at serine 129, or total-alpha-synuclein in CSF from the longitudinal Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study cohort (n = 121). Tocopherols 278-288 synuclein alpha Homo sapiens 112-127 27548849-6 2016 RESULTS: Interestingly, total-alpha-synuclein and oligomeric-alpha-synuclein levels significantly increased during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study follow-up period, whereas phosphorylated-alpha-synuclein at serine 129 levels showed a longitudinal decrease. Tocopherols 139-149 synuclein alpha Homo sapiens 30-45 27548849-6 2016 RESULTS: Interestingly, total-alpha-synuclein and oligomeric-alpha-synuclein levels significantly increased during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study follow-up period, whereas phosphorylated-alpha-synuclein at serine 129 levels showed a longitudinal decrease. Tocopherols 139-149 synuclein alpha Homo sapiens 61-76 27548849-6 2016 RESULTS: Interestingly, total-alpha-synuclein and oligomeric-alpha-synuclein levels significantly increased during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study follow-up period, whereas phosphorylated-alpha-synuclein at serine 129 levels showed a longitudinal decrease. Tocopherols 139-149 synuclein alpha Homo sapiens 61-76 27548849-8 2016 A strong positive correlation between the changes in CSF total-alpha-synuclein and oligomeric-alpha-synuclein during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study was also noted (r = 0.84, P < .001). Tocopherols 141-151 synuclein alpha Homo sapiens 63-78 27548849-8 2016 A strong positive correlation between the changes in CSF total-alpha-synuclein and oligomeric-alpha-synuclein during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study was also noted (r = 0.84, P < .001). Tocopherols 141-151 synuclein alpha Homo sapiens 94-109 29196050-9 2018 Tocopherol (10-7M) itself can induce the cyclooxygenase activity and shift the COX-1 and COX-2 ratio to COX-2. Tocopherols 0-10 cytochrome c oxidase I, mitochondrial Rattus norvegicus 79-84 29196050-9 2018 Tocopherol (10-7M) itself can induce the cyclooxygenase activity and shift the COX-1 and COX-2 ratio to COX-2. Tocopherols 0-10 cytochrome c oxidase II, mitochondrial Rattus norvegicus 89-94 28074485-3 2017 Across all growth conditions, xylem anatomy correlated with transpiration rate, while phloem anatomy correlated with photosynthetic capacity for two plant lines (wild-type Col-0 and tocopherol-deficient vte1 mutant) irrespective of tocopherol status. Tocopherols 182-192 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 203-207 28397308-8 2017 RESULTS: Islets treated with IBMX/tocopherol exhibited the highest fold change in the relative expression of PDX1 on day 5 post-treatment (relative expression: 6.80+-2.08), whereas serum-treated islets showed the lowest fold changes in PDX1 expression on day 5 post-treatment (0.67+-0.36), as compared with the expression on day 1 post-treatment. Tocopherols 34-44 pancreatic and duodenal homeobox 1 Homo sapiens 109-113 28397308-8 2017 RESULTS: Islets treated with IBMX/tocopherol exhibited the highest fold change in the relative expression of PDX1 on day 5 post-treatment (relative expression: 6.80+-2.08), whereas serum-treated islets showed the lowest fold changes in PDX1 expression on day 5 post-treatment (0.67+-0.36), as compared with the expression on day 1 post-treatment. Tocopherols 34-44 pancreatic and duodenal homeobox 1 Homo sapiens 236-240 28211759-11 2017 Impact statement Gamma tocopherol has shown ameliorative effect on diabetic wound healing by regulation of inflammation, oxidative stress, and apoptosis demonstrated by nuclear factor kappa B, nuclear factor (erythroid derived 2)-like 2, and sirtuin-1. Tocopherols 23-33 sirtuin 1 Mus musculus 242-251 27726859-7 2016 Subcellular localization analysis using GFP-fusion proteins and confocal microscopy showed that AtTAT1, AtTAT2, and HPP dioxygenase (HPPD), which catalyzes the subsequent step of TAT, are localized in the cytosol, unlike plastid-localized Tyr and tocopherol biosynthetic enzymes. Tocopherols 247-257 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 116-131 27726859-7 2016 Subcellular localization analysis using GFP-fusion proteins and confocal microscopy showed that AtTAT1, AtTAT2, and HPP dioxygenase (HPPD), which catalyzes the subsequent step of TAT, are localized in the cytosol, unlike plastid-localized Tyr and tocopherol biosynthetic enzymes. Tocopherols 247-257 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 133-137 27016075-5 2016 Both 13"-COOHs are much stronger than tocopherols in inhibition of pro-inflammatory and cancer promoting cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), and in induction of apoptosis and autophagy in colon cancer cells. Tocopherols 38-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 27016075-5 2016 Both 13"-COOHs are much stronger than tocopherols in inhibition of pro-inflammatory and cancer promoting cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), and in induction of apoptosis and autophagy in colon cancer cells. Tocopherols 38-49 arachidonate 5-lipoxygenase Homo sapiens 134-148 27246092-10 2016 In livers of CLA-fed dams, tocopherol concentrations decreased by 24 % but expression of TTPA and CYP3A1, involved in tocopherol transport and metabolism, were not influenced. Tocopherols 118-128 alpha tocopherol transfer protein Rattus norvegicus 89-93 27246092-10 2016 In livers of CLA-fed dams, tocopherol concentrations decreased by 24 % but expression of TTPA and CYP3A1, involved in tocopherol transport and metabolism, were not influenced. Tocopherols 118-128 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 98-104 26454640-5 2015 Chlamydomonas genomic DNA analysis suggests that HPT is encoded by a single gene, HPT1, whose promoter region contains multiple motifs related to regulation by jasmonate, abscisic acid, low temperature and light, and an ATCTA motif presents in genes involved in tocopherol biosynthesis and some photosynthesis-related genes. Tocopherols 262-272 uncharacterized protein Chlamydomonas reinhardtii 82-86 28097126-10 2016 Administration of JNK inhibitor SP600125 or ROS scavenger tocopherol with TMZ and NAMPT inhibitors substantially attenuated the sensitization of NAMPT inhibitor on TMZ antitumor action. Tocopherols 58-68 nicotinamide phosphoribosyltransferase Homo sapiens 82-87 28097126-10 2016 Administration of JNK inhibitor SP600125 or ROS scavenger tocopherol with TMZ and NAMPT inhibitors substantially attenuated the sensitization of NAMPT inhibitor on TMZ antitumor action. Tocopherols 58-68 nicotinamide phosphoribosyltransferase Homo sapiens 145-150 26165176-0 2015 Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer. Tocopherols 23-34 kallikrein related peptidase 3 Homo sapiens 50-81 26165176-6 2015 Linear regression was used to estimate least-square means comparing PSA levels of men with high versus low carotenoid/tocopherol levels, adjusting for covariates. Tocopherols 118-128 kallikrein related peptidase 3 Homo sapiens 68-71 26165176-10 2015 CONCLUSIONS: Certain plasma carotenoids and tocopherols were related inversely to PSA levels at various timepoints, suggesting that greater intake of foods containing these micronutrients might be beneficial to men with PSA-defined PrCA recurrence. Tocopherols 44-55 kallikrein related peptidase 3 Homo sapiens 82-85 26452599-9 2015 Double mutant plants (vte5 vte6) are tocopherol deficient and contain more chlorophyll, but reduced amounts of phytol and phytyl-phosphate compared with vte6 mutants, suggesting that phytol or phytyl-phosphate are detrimental to plant growth. Tocopherols 37-47 phytol kinase 1 VTE5 Arabidopsis thaliana 22-26 26048882-2 2015 Recent studies have pointed to the involvement of chlorophyll-linked reduction of geranylgeranyl by geranylgeranyl reductase as a major pathway for the synthesis of the PDP precursor of tocopherols. Tocopherols 186-197 geranylgeranyl reductase Arabidopsis thaliana 100-124 26048882-3 2015 This indirect pathway of PDP synthesis suggests a key role of chlorophyll synthase in tocopherol production to generate the geranylgeranyl-chlorophyll substrate for geranylgeranyl reductase. Tocopherols 86-96 geranylgeranyl reductase Arabidopsis thaliana 165-189 26582657-6 2016 Supplementation with a gamma-T-rich mixture of tocopherols (gamma-TmT, 0.3% in diet) significantly inhibited the development of mPIN lesions and reduced PhIP-induced elevation of 8-oxo-deoxyguanosine, COX-2, nitrotyrosine, Ki-67 and p-AKT, and the loss of PTEN and Nrf2. Tocopherols 47-58 dynein light chain LC8-type 1 Mus musculus 128-132 26582657-6 2016 Supplementation with a gamma-T-rich mixture of tocopherols (gamma-TmT, 0.3% in diet) significantly inhibited the development of mPIN lesions and reduced PhIP-induced elevation of 8-oxo-deoxyguanosine, COX-2, nitrotyrosine, Ki-67 and p-AKT, and the loss of PTEN and Nrf2. Tocopherols 47-58 cytochrome c oxidase II, mitochondrial Mus musculus 201-206 26582657-6 2016 Supplementation with a gamma-T-rich mixture of tocopherols (gamma-TmT, 0.3% in diet) significantly inhibited the development of mPIN lesions and reduced PhIP-induced elevation of 8-oxo-deoxyguanosine, COX-2, nitrotyrosine, Ki-67 and p-AKT, and the loss of PTEN and Nrf2. Tocopherols 47-58 antigen identified by monoclonal antibody Ki 67 Mus musculus 223-228 26582657-6 2016 Supplementation with a gamma-T-rich mixture of tocopherols (gamma-TmT, 0.3% in diet) significantly inhibited the development of mPIN lesions and reduced PhIP-induced elevation of 8-oxo-deoxyguanosine, COX-2, nitrotyrosine, Ki-67 and p-AKT, and the loss of PTEN and Nrf2. Tocopherols 47-58 phosphatase and tensin homolog Mus musculus 256-260 26582657-6 2016 Supplementation with a gamma-T-rich mixture of tocopherols (gamma-TmT, 0.3% in diet) significantly inhibited the development of mPIN lesions and reduced PhIP-induced elevation of 8-oxo-deoxyguanosine, COX-2, nitrotyrosine, Ki-67 and p-AKT, and the loss of PTEN and Nrf2. Tocopherols 47-58 nuclear factor, erythroid derived 2, like 2 Mus musculus 265-269 26224411-8 2016 Furthermore, we showed that the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone. Tocopherols 145-156 geranylgeranyl pyrophosphate synthase 1 Arabidopsis thaliana 32-39 26013323-2 2015 It was found that plastoquinone-C accumulates mainly in the reduced form under high light conditions, as well as during short-term excess light illumination both in the wild-type and tocopherol biosynthetic vte1 mutant, suggesting that plastoquinone-C, a singlet oxygen-derived prenyllipid, is reduced in chloroplasts by photosystem II or enzymatically, outside thylakoids. Tocopherols 183-193 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 207-211 26454640-8 2015 The regulatory expression pattern of HPT1 and the changes of tocopherol abundance support the idea that different tocopherols play specific functions, and suggest a role for gamma-tocopherol in the adaptation to growth under low-temperature. Tocopherols 114-125 uncharacterized protein Chlamydomonas reinhardtii 37-41 26054501-5 2015 Here we systematically investigate the influence of different tocopherols on Abeta production and degradation in neuronal cell lines. Tocopherols 62-73 amyloid beta precursor protein Homo sapiens 77-82 26054501-7 2015 RESULTS: Surprisingly, all tocopherols have shown to increase Abeta level by enhancing the Abeta production and decreasing the Abeta degradation. Tocopherols 27-38 amyloid beta precursor protein Homo sapiens 62-67 26054501-7 2015 RESULTS: Surprisingly, all tocopherols have shown to increase Abeta level by enhancing the Abeta production and decreasing the Abeta degradation. Tocopherols 27-38 amyloid beta precursor protein Homo sapiens 91-96 26054501-7 2015 RESULTS: Surprisingly, all tocopherols have shown to increase Abeta level by enhancing the Abeta production and decreasing the Abeta degradation. Tocopherols 27-38 amyloid beta precursor protein Homo sapiens 91-96 26054501-12 2015 CONCLUSIONS: Our results suggest that beside the beneficial antioxidative effects of vitamin E, tocopherol has in respect to AD also a potency to increase the amyloid-beta level, which differ for the analysed tocopherols. Tocopherols 96-106 amyloid beta precursor protein Homo sapiens 159-171 23406955-7 2015 Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. Tocopherols 25-35 tumor necrosis factor-like Rattus norvegicus 79-82 23406955-7 2015 Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. Tocopherols 25-35 interleukin 4 Rattus norvegicus 90-94 23406955-7 2015 Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. Tocopherols 25-35 interleukin 6 Rattus norvegicus 96-100 23406955-7 2015 Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. Tocopherols 25-35 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 120-125 25749732-5 2015 On the other hand, the loss of tocopherol in vte1 mutants was compensated by the increase of zeaxanthin and anthocyanin contents, which armed vte1 mutants with higher heat dissipation capacity in PS II and higher antioxidative capacity than vtc mutants. Tocopherols 31-41 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 45-49 25575988-4 2015 The expression of vitamin C defective 2 (VTC2) and tocopherol cyclase (TC) genes, which encode key enzymes in the AsA and Toc biosynthetic pathways, respectively, was affected by illumination and darkness in parallel with the levels of both these antioxidants. Tocopherols 122-125 GDP-D-glucose phosphorylase 1 Homo sapiens 18-39 25749732-2 2015 The mutants of Arabidopsis thaliana deficient in ascorbate (vtc1 and vtc2) or tocopherol (vte1) were used to analyze their physiological, biochemical and metabolic change in responses to Ultraviolet B radiation. Tocopherols 78-88 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 90-94 25766837-6 2015 In addition to its role as the HDL receptor, SRB1 is also involved in pathogen recognition, identification of apoptotic cells, tissue antioxidant uptake (tocopherol and carotenoids), and lung surfactant composition, all factors involved in COPD pathogenesis. Tocopherols 154-164 scavenger receptor class B member 1 Homo sapiens 45-49 25724683-0 2015 Tocopherol isoforms (alpha-, gamma-, and delta-) show distinct capacities to control Nrf-2 and NfkappaB signaling pathways that modulate inflammatory response in Caco-2 intestinal cells. Tocopherols 0-10 NFE2 like bZIP transcription factor 2 Homo sapiens 85-90 25724683-0 2015 Tocopherol isoforms (alpha-, gamma-, and delta-) show distinct capacities to control Nrf-2 and NfkappaB signaling pathways that modulate inflammatory response in Caco-2 intestinal cells. Tocopherols 0-10 nuclear factor kappa B subunit 1 Homo sapiens 95-103 25428995-2 2015 Depletion of SXD1 activity in maize and potato leaves leads to tocopherol deficiency and a "sugar export block" phenotype that comprises massive starch accumulation and obstruction of plasmodesmata in paraveinal tissue by callose. Tocopherols 63-73 tocopherol cyclase, chloroplastic Zea mays 13-17 25428995-3 2015 We grew two transgenic StSXD1:RNAi potato lines with severe tocopherol deficiency under moderate light conditions and subjected them to salt stress. Tocopherols 60-70 tocopherol cyclase Solanum tuberosum 23-29 25575988-4 2015 The expression of vitamin C defective 2 (VTC2) and tocopherol cyclase (TC) genes, which encode key enzymes in the AsA and Toc biosynthetic pathways, respectively, was affected by illumination and darkness in parallel with the levels of both these antioxidants. Tocopherols 122-125 GDP-D-glucose phosphorylase 1 Homo sapiens 41-45 24983950-0 2014 Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange. Tocopherols 33-43 transporter 1, ATP binding cassette subfamily B member Homo sapiens 72-77 25654502-6 2015 Enzymatic antioxidants including superoxide dismutase, catalase, glutathione reductase, and non-enzymatic antioxidants such as tocopherol, ascorbic acid and glutathione were decreased in the Abeta treated group when compared to the control group. Tocopherols 127-137 amyloid beta precursor protein Rattus norvegicus 191-196 25326132-0 2015 Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. Tocopherols 63-73 notch 3 Mus musculus 16-22 25326132-0 2015 Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. Tocopherols 63-73 hes family bHLH transcription factor 1 Mus musculus 23-27 25579226-5 2015 Finally, we report that treatment with the antioxidant tocopherol attenuates glutamate induced-ROS increase, release of mitochondrial Opa1 and cytochrome c, and prevents cell death. Tocopherols 55-65 OPA1, mitochondrial dynamin like GTPase Mus musculus 134-138 25183412-5 2014 We found that the pretreatment with both total extracts of tocopherols and sphingolipids is able to counterbalance cell atrophy, reducing the decrease in myotube size and myonuclei number, and attenuating protein degradation and the increase in expression of MAFbx/atrogin-1 (a muscle-specific atrophy marker). Tocopherols 59-70 F-box protein 32 Homo sapiens 259-264 25183412-5 2014 We found that the pretreatment with both total extracts of tocopherols and sphingolipids is able to counterbalance cell atrophy, reducing the decrease in myotube size and myonuclei number, and attenuating protein degradation and the increase in expression of MAFbx/atrogin-1 (a muscle-specific atrophy marker). Tocopherols 59-70 F-box protein 32 Homo sapiens 265-274 25059706-9 2014 Meanwhile, seeds of wild-type over-expressing NYE1 had lower tocopherol levels, suggesting that phytol derived from NYE1-dependent chlorophyll degradation probably doesn"t enter tocopherol biosynthesis. Tocopherols 61-71 non-yellowing 1 Arabidopsis thaliana 46-50 24983950-0 2014 Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange. Tocopherols 33-43 SEC14 like lipid binding 2 Homo sapiens 78-85 23434765-5 2014 Chemicals, including antioxidants, tocopherols including alpha-tocopherol (vitamin E), and phytochemicals, and radiation antagonize the Nrf2:INrf2 interaction and lead to the stabilization and activation of Nrf2. Tocopherols 35-46 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 24258793-2 2014 The conversion of gamma- to alpha-tocopherol catalyzed by gamma-tocopherol methyltransferase (gamma-TMT) is found to be the rate limiting factor in soybean which influences the tocopherol composition. Tocopherols 34-44 gamma-tocopherol methyltransferase Glycine max 58-92 24258793-2 2014 The conversion of gamma- to alpha-tocopherol catalyzed by gamma-tocopherol methyltransferase (gamma-TMT) is found to be the rate limiting factor in soybean which influences the tocopherol composition. Tocopherols 34-44 gamma-tocopherol methyltransferase Glycine max 94-103 24648045-9 2014 We hypothesized that the low-binding affinity of tocotrienols to ATTP is due to the relatively more rigid tail structure of the tocotrienols in comparison with that of the tocopherols. Tocopherols 172-183 alpha tocopherol transfer protein Homo sapiens 65-69 23848570-1 2014 In the present study, singlet oxygen (1O2) scavenging activity of tocopherol and plastochromanol was examined in tocopherol cyclase-deficient mutant (vte1) of Arabidopsis thaliana lacking both tocopherol and plastochromanol. Tocopherols 66-76 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 150-154 23848570-1 2014 In the present study, singlet oxygen (1O2) scavenging activity of tocopherol and plastochromanol was examined in tocopherol cyclase-deficient mutant (vte1) of Arabidopsis thaliana lacking both tocopherol and plastochromanol. Tocopherols 113-123 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 150-154 23848570-2 2014 It is demonstrated here that suppression of tocopherol and plastochromanol synthesis in chloroplasts isolated from vte1 Arabidopsis plants enhanced 1O2 formation under high light illumination as monitored by electron paramagnetic resonance spin-trapping spectroscopy. Tocopherols 44-54 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 115-119 24304651-2 2014 Gel-forming compounds-grafted silica particles (Sil-G1 and Sil-G2) were then applied for the liquid chromatographic separation of shape-constrained isomers of polycyclic aromatic hydrocarbons (PAHs) and tocopherols as stationary phases. Tocopherols 203-214 STIL centriolar assembly protein Homo sapiens 48-51 25059706-7 2014 Tocopherol content of seeds from double mutants in NONYELLOWING1 (NYE1) and NYE2, regulators of chlorophyll degradation, had modest reduction compared with wild-type seeds, although mature seeds of the double mutant retained significantly higher chlorophyll levels. Tocopherols 0-10 non-yellowing 1 Arabidopsis thaliana 51-64 25059706-7 2014 Tocopherol content of seeds from double mutants in NONYELLOWING1 (NYE1) and NYE2, regulators of chlorophyll degradation, had modest reduction compared with wild-type seeds, although mature seeds of the double mutant retained significantly higher chlorophyll levels. Tocopherols 0-10 non-yellowing 1 Arabidopsis thaliana 66-70 25059706-7 2014 Tocopherol content of seeds from double mutants in NONYELLOWING1 (NYE1) and NYE2, regulators of chlorophyll degradation, had modest reduction compared with wild-type seeds, although mature seeds of the double mutant retained significantly higher chlorophyll levels. Tocopherols 0-10 STAY-GREEN-like protein Arabidopsis thaliana 76-80 24780318-2 2014 We investigated whether an antioxidant (tocopherol) can reduce the effect of terbutaline in beta-2-adrenergic receptor (beta2-AR)-regulated smooth muscles. Tocopherols 40-50 adrenoceptor beta 2 Rattus norvegicus 92-118 24780318-2 2014 We investigated whether an antioxidant (tocopherol) can reduce the effect of terbutaline in beta-2-adrenergic receptor (beta2-AR)-regulated smooth muscles. Tocopherols 40-50 adrenoceptor beta 2 Rattus norvegicus 120-128 23434765-5 2014 Chemicals, including antioxidants, tocopherols including alpha-tocopherol (vitamin E), and phytochemicals, and radiation antagonize the Nrf2:INrf2 interaction and lead to the stabilization and activation of Nrf2. Tocopherols 35-46 kelch like ECH associated protein 1 Homo sapiens 141-146 23434765-5 2014 Chemicals, including antioxidants, tocopherols including alpha-tocopherol (vitamin E), and phytochemicals, and radiation antagonize the Nrf2:INrf2 interaction and lead to the stabilization and activation of Nrf2. Tocopherols 35-46 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 24136788-0 2013 Modulation of NF-kappaB and Nrf2 control of inflammatory responses in FHs 74 Int cell line is tocopherol isoform-specific. Tocopherols 94-104 nuclear factor kappa B subunit 1 Homo sapiens 14-23 24267661-5 2014 The abc1k1/pgr6 single mutant is specifically deficient in the electron carrier plastoquinone, as well as in beta-carotene and the xanthophyll lutein, and is defective in membrane antioxidant tocopherol metabolism. Tocopherols 192-202 Protein kinase superfamily protein Arabidopsis thaliana 4-10 24267661-5 2014 The abc1k1/pgr6 single mutant is specifically deficient in the electron carrier plastoquinone, as well as in beta-carotene and the xanthophyll lutein, and is defective in membrane antioxidant tocopherol metabolism. Tocopherols 192-202 Protein kinase superfamily protein Arabidopsis thaliana 11-15 24267661-8 2014 Moreover, ABC1K1 behaves as an active kinase and phosphorylates VTE1, a key enzyme of tocopherol (vitamin E) metabolism in vitro. Tocopherols 86-96 Protein kinase superfamily protein Arabidopsis thaliana 10-16 24267661-8 2014 Moreover, ABC1K1 behaves as an active kinase and phosphorylates VTE1, a key enzyme of tocopherol (vitamin E) metabolism in vitro. Tocopherols 86-96 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 64-68 24136788-0 2013 Modulation of NF-kappaB and Nrf2 control of inflammatory responses in FHs 74 Int cell line is tocopherol isoform-specific. Tocopherols 94-104 NFE2 like bZIP transcription factor 2 Homo sapiens 28-32 23812214-0 2013 Inhibitory effects of tocopherols on expression of the cyclooxygenase-2 gene in RAW264.7 cells stimulated by lipopolysaccharide, tumor necrosis factor-alpha or Porphyromonas gingivalis fimbriae. Tocopherols 22-33 prostaglandin-endoperoxide synthase 2 Mus musculus 55-71 23946344-5 2013 Apolipoprotein B-independent secretion of tocopherols (and cholesterol) was greatly enhanced by the liver X receptor agonist T0901317. Tocopherols 42-53 apolipoprotein B Homo sapiens 0-16 23946344-6 2013 T0901317 induced ATP-binding cassette transporter A1 (ABCA1) protein expression and basolateral secretion of tocopherols to apolipoprotein A1. Tocopherols 109-120 apolipoprotein A1 Homo sapiens 124-141 23946344-9 2013 Basal addition of scavenger receptor class B member I (SR-BI) blocking antibody, which inhibits the interaction between SR-BI and HDL, increased basal accumulation of all tocopherols, demonstrating a role for SR-BI in cellular re-uptake of secreted vitamin E. Tocopherols 171-182 scavenger receptor class B member 1 Homo sapiens 18-53 23946344-9 2013 Basal addition of scavenger receptor class B member I (SR-BI) blocking antibody, which inhibits the interaction between SR-BI and HDL, increased basal accumulation of all tocopherols, demonstrating a role for SR-BI in cellular re-uptake of secreted vitamin E. Tocopherols 171-182 scavenger receptor class B member 1 Homo sapiens 55-60 22389237-0 2013 Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Tocopherols 8-19 estrogen receptor 1 Rattus norvegicus 71-78 24589959-5 2014 Treatment with tyrostat, tocotrienol-rich fraction or tocopherol decreased melanin content and down-regulated TYR, TYRP1 and TYRP2 genes with decreased tyrosinase activity. Tocopherols 54-64 tyrosinase related protein 1 Homo sapiens 115-120 24589959-5 2014 Treatment with tyrostat, tocotrienol-rich fraction or tocopherol decreased melanin content and down-regulated TYR, TYRP1 and TYRP2 genes with decreased tyrosinase activity. Tocopherols 54-64 dopachrome tautomerase Homo sapiens 125-130 24589959-5 2014 Treatment with tyrostat, tocotrienol-rich fraction or tocopherol decreased melanin content and down-regulated TYR, TYRP1 and TYRP2 genes with decreased tyrosinase activity. Tocopherols 54-64 tyrosinase Homo sapiens 152-162 24589959-7 2014 These findings indicated that tyrostat, tocotrienol-rich fraction and tocopherol inhibit melanogenesis by modulating the expression of genes involved in the regulation of melanin synthesis and inhibiting tyrosinase activity. Tocopherols 70-80 tyrosinase Homo sapiens 204-214 24117100-6 2013 The total tocopherol content of SL1-1, SL1-2, SL2-1, and SL2-2 were 70.46, 68.79, 79.64, and 79.31 mug/g, respectively. Tocopherols 10-20 TATA-box binding protein associated factor, RNA polymerase I subunit A Homo sapiens 32-37 24117100-6 2013 The total tocopherol content of SL1-1, SL1-2, SL2-1, and SL2-2 were 70.46, 68.79, 79.64, and 79.31 mug/g, respectively. Tocopherols 10-20 TATA-box binding protein associated factor, RNA polymerase I subunit A Homo sapiens 39-44 24117100-6 2013 The total tocopherol content of SL1-1, SL1-2, SL2-1, and SL2-2 were 70.46, 68.79, 79.64, and 79.31 mug/g, respectively. Tocopherols 10-20 MAP6 domain containing 1 Homo sapiens 46-51 24117100-6 2013 The total tocopherol content of SL1-1, SL1-2, SL2-1, and SL2-2 were 70.46, 68.79, 79.64, and 79.31 mug/g, respectively. Tocopherols 10-20 matrix metallopeptidase 10 Homo sapiens 57-62 24025632-10 2013 Last, calcium and tocopherol reduced the number of mucin-depleted foci per colon in rats compared with nonsupplemented cured meat (P = 0.01). Tocopherols 18-28 solute carrier family 13 member 2 Rattus norvegicus 51-56 23812214-0 2013 Inhibitory effects of tocopherols on expression of the cyclooxygenase-2 gene in RAW264.7 cells stimulated by lipopolysaccharide, tumor necrosis factor-alpha or Porphyromonas gingivalis fimbriae. Tocopherols 22-33 tumor necrosis factor Mus musculus 129-156 23812214-7 2013 COX2 gene expression in RAW cells after exposure to the three different macrophage activators was inhibited by the tocopherols (p<0.01). Tocopherols 115-126 prostaglandin-endoperoxide synthase 2 Mus musculus 0-4 22653610-2 2013 Milk quality was assessed by quantitative descriptive sensory analysis and by analysis of tocopherols and carotenoids as well as fatty acid composition. Tocopherols 90-101 Weaning weight-maternal milk Bos taurus 0-4 23632854-5 2013 Using a nontargeted lipidomics approach, we demonstrate that plants lacking the plastoglobule ABC1-like kinase ABC1K3 are defective both for the production of plastochromanol-8 (a plastoquinone-derived lipid antioxidant) and the redox recycling of alpha-tocopherol, whereas tocopherol production is not affected. Tocopherols 254-264 Protein kinase superfamily protein Arabidopsis thaliana 111-117 23137278-2 2013 By contrast, vitamin E tocopherol synthesis is mediated by homogentisate phytyltransferase (HPT), which condenses homogentisate and the saturated C20 isoprenoid phytyl diphosphate (PDP). Tocopherols 23-33 homogentisate phytyltransferase 1 Arabidopsis thaliana 59-90 22389237-0 2013 Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Tocopherols 8-19 peroxisome proliferator-activated receptor gamma Rattus norvegicus 80-89 22389237-0 2013 Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Tocopherols 8-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-99 22763803-11 2012 Besides, intrayolk injection of tocopherol, an antioxidant, provoked a decrease in the levels of aBC expression in myelinating OLs. Tocopherols 32-42 crystallin alpha B Gallus gallus 97-100 23512990-2 2013 Tocopherols are the predominant form of vitamin E found in the diet and in supplements and have garnered interest for their potential cancer therapeutic and preventive effects, such as the dephosphorylation of Akt, a serine/threonine kinase with a pivotal role in cell growth, survival, and metabolism. Tocopherols 0-11 AKT serine/threonine kinase 1 Homo sapiens 210-213 23512990-6 2013 Binding affinities for the PH domains of Akt and PHLPP1 were greater than for other PH domain-containing proteins, which may underlie the preferential recruitment of these proteins to membranes containing tocopherols. Tocopherols 205-216 AKT serine/threonine kinase 1 Homo sapiens 41-44 23512990-6 2013 Binding affinities for the PH domains of Akt and PHLPP1 were greater than for other PH domain-containing proteins, which may underlie the preferential recruitment of these proteins to membranes containing tocopherols. Tocopherols 205-216 PH domain and leucine rich repeat protein phosphatase 1 Homo sapiens 49-55 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 35-46 AKT serine/threonine kinase 1 Homo sapiens 83-86 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 35-46 AKT serine/threonine kinase 1 Homo sapiens 262-265 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 155-166 AKT serine/threonine kinase 1 Homo sapiens 83-86 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 155-166 AKT serine/threonine kinase 1 Homo sapiens 262-265 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 155-166 AKT serine/threonine kinase 1 Homo sapiens 83-86 23512990-8 2013 By describing a mechanism by which tocopherols facilitate the dephosphorylation of Akt at Ser473, we provide insights into the mode of antitumor action of tocopherols and a rationale for the translational development of tocopherols into novel PH domain-targeted Akt inhibitors. Tocopherols 155-166 AKT serine/threonine kinase 1 Homo sapiens 262-265 24396567-8 2013 Type I procollagen and type III procollagen protein levels were significantly increased in response to biodynes, TRF, and tocopherol treatment (P < 0.05) with reduction in MMP-1, MMP-2, MMP-3, and MMP-9 activities (P < 0.05). Tocopherols 122-132 matrix metallopeptidase 1 Homo sapiens 175-180 24396567-8 2013 Type I procollagen and type III procollagen protein levels were significantly increased in response to biodynes, TRF, and tocopherol treatment (P < 0.05) with reduction in MMP-1, MMP-2, MMP-3, and MMP-9 activities (P < 0.05). Tocopherols 122-132 matrix metallopeptidase 2 Homo sapiens 182-187 24396567-8 2013 Type I procollagen and type III procollagen protein levels were significantly increased in response to biodynes, TRF, and tocopherol treatment (P < 0.05) with reduction in MMP-1, MMP-2, MMP-3, and MMP-9 activities (P < 0.05). Tocopherols 122-132 matrix metallopeptidase 3 Homo sapiens 189-194 24396567-8 2013 Type I procollagen and type III procollagen protein levels were significantly increased in response to biodynes, TRF, and tocopherol treatment (P < 0.05) with reduction in MMP-1, MMP-2, MMP-3, and MMP-9 activities (P < 0.05). Tocopherols 122-132 matrix metallopeptidase 9 Homo sapiens 200-205 22846036-0 2012 Effect of PPG-PEG-PPG on the tocopherol-controlled release from films intended for food-packaging applications. Tocopherols 29-39 serglycin Homo sapiens 10-13 22872679-4 2012 Dihydrosphingosine as well as cholesterol, fatty acid, and tocopherol was conjugated to highly conserved, short HIV-1 Env-derived peptides with no antiviral activity otherwise. Tocopherols 59-69 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 118-121 22846036-0 2012 Effect of PPG-PEG-PPG on the tocopherol-controlled release from films intended for food-packaging applications. Tocopherols 29-39 serglycin Homo sapiens 18-21 22846036-4 2012 The use of different chain extenders as polymer modifiers (PE-PEG M(w), 575; and PPG-PEG-PPG M(w), 2000) has caused significant changes in tocopherol-specific release properties. Tocopherols 139-149 serglycin Homo sapiens 81-84 22846036-4 2012 The use of different chain extenders as polymer modifiers (PE-PEG M(w), 575; and PPG-PEG-PPG M(w), 2000) has caused significant changes in tocopherol-specific release properties. Tocopherols 139-149 serglycin Homo sapiens 89-92 22846036-8 2012 Varying the structural features of the films with the incorporation of different levels of PPG-PEG-PPG, the release of tocopherol (food-packaging additive) into different ethanolic simulants could be clearly controlled. Tocopherols 119-129 serglycin Homo sapiens 91-94 22846036-8 2012 Varying the structural features of the films with the incorporation of different levels of PPG-PEG-PPG, the release of tocopherol (food-packaging additive) into different ethanolic simulants could be clearly controlled. Tocopherols 119-129 serglycin Homo sapiens 99-102 22665481-7 2012 This metabolic deficit in Cyp4f14(-/-) mice was partially offset by increased fecal excretion of nonmetabolized tocopherols and of novel omega-1- and omega-2-hydroxytocopherols. Tocopherols 112-123 cytochrome P450, family 4, subfamily f, polypeptide 14 Mus musculus 26-33 22699229-6 2012 The complete baseline separation of tocopherol isomers in an isocratic mode has been achieved within 25 min with the Sil-poly(ODA-alt-DGMI). Tocopherols 36-46 STIL centriolar assembly protein Homo sapiens 117-120 21929836-3 2012 Conversely to NBD-cholesterol, the uptakes of [3H]cholesterol and tocopherol by Caco-2 cells were impaired by both block lipid transport-1 and ezetimibe, which inhibit SR-BI and NPC1L1, respectively. Tocopherols 66-76 scavenger receptor class B member 1 Homo sapiens 168-173 22361804-0 2012 Transgenic rice grains expressing a heterologous rho-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the gamma to the alpha isoform without increasing absolute tocopherol levels. Tocopherols 93-103 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 49-86 22361804-0 2012 Transgenic rice grains expressing a heterologous rho-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the gamma to the alpha isoform without increasing absolute tocopherol levels. Tocopherols 178-188 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 49-86 21929836-3 2012 Conversely to NBD-cholesterol, the uptakes of [3H]cholesterol and tocopherol by Caco-2 cells were impaired by both block lipid transport-1 and ezetimibe, which inhibit SR-BI and NPC1L1, respectively. Tocopherols 66-76 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 178-184 21929836-10 2012 Thus, cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI and NPC1L1. Tocopherols 22-32 scavenger receptor class B, member 1 Mus musculus 179-184 21929836-10 2012 Thus, cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI and NPC1L1. Tocopherols 22-32 NPC1 like intracellular cholesterol transporter 1 Mus musculus 189-195 22457388-0 2012 A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. Tocopherols 35-46 nuclear factor, erythroid derived 2, like 2 Mus musculus 57-61 22457388-0 2012 A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. Tocopherols 35-46 tumor necrosis factor receptor superfamily, member 25 Mus musculus 95-100 22204937-7 2012 As a result, the higher separation ability toward tocopherols and carotenoids was obtained on Sil-poy(ODA-alt-OMI). Tocopherols 50-61 STIL centriolar assembly protein Homo sapiens 94-97 22226829-0 2012 The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice. Tocopherols 52-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 22457388-3 2012 We previously showed that dietary feeding of a gamma-tocopherol-rich mixture of tocopherols (gamma-TmT) suppressed prostate tumorigenesis in TRAMP mice associated with higher Nrf2 protein expression. Tocopherols 80-91 tumor necrosis factor receptor superfamily, member 25 Mus musculus 141-146 22457388-3 2012 We previously showed that dietary feeding of a gamma-tocopherol-rich mixture of tocopherols (gamma-TmT) suppressed prostate tumorigenesis in TRAMP mice associated with higher Nrf2 protein expression. Tocopherols 80-91 nuclear factor, erythroid derived 2, like 2 Mus musculus 175-179 21848500-8 2012 Pre Orchiectomy Tocopherol and Orchiectomy Full Tocopherol groups presented caspase-3 levels lower than the Orchiectomy group (0.0072). Tocopherols 48-58 caspase 3 Rattus norvegicus 76-85 22226829-7 2012 Interestingly, the serum levels of tocopherol metabolites, specifically the gamma- and delta-forms of carboxymethylbutyl hydroxychroman and carboxyethyl hydroxychroman, in Nrf2 (-/-) mice were significantly higher than those in wild-type mice. Tocopherols 35-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 172-176 22226829-8 2012 These findings suggest that the antioxidant and anti-inflammatory activities of gamma-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites. Tocopherols 142-153 nuclear factor, erythroid derived 2, like 2 Mus musculus 296-300 22226829-8 2012 These findings suggest that the antioxidant and anti-inflammatory activities of gamma-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites. Tocopherols 142-153 nuclear factor, erythroid derived 2, like 2 Mus musculus 311-315 22226829-8 2012 These findings suggest that the antioxidant and anti-inflammatory activities of gamma-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites. Tocopherols 142-152 nuclear factor, erythroid derived 2, like 2 Mus musculus 296-300 22226829-8 2012 These findings suggest that the antioxidant and anti-inflammatory activities of gamma-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites. Tocopherols 142-152 nuclear factor, erythroid derived 2, like 2 Mus musculus 311-315 22042641-6 2012 In contrast to the dietary intake, alpha-tocopherol, which has the highest affinity for alpha-tocopherol transfer protein (alphaTTP), inhibited uptake of gamma-tocotrienol to tissues including adipose tissue after oral administration, suggesting that the affinities of tocopherol and tocotrienol for alphaTTP in the liver were the critical determinants of their uptake to peripheral tissues. Tocopherols 41-51 alpha tocopherol transfer protein Rattus norvegicus 88-121 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 interleukin 6 Homo sapiens 56-60 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 kinase insert domain receptor Homo sapiens 72-75 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 tumor necrosis factor Homo sapiens 117-125 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 vascular endothelial growth factor A Homo sapiens 160-164 22042641-6 2012 In contrast to the dietary intake, alpha-tocopherol, which has the highest affinity for alpha-tocopherol transfer protein (alphaTTP), inhibited uptake of gamma-tocotrienol to tissues including adipose tissue after oral administration, suggesting that the affinities of tocopherol and tocotrienol for alphaTTP in the liver were the critical determinants of their uptake to peripheral tissues. Tocopherols 41-51 alpha tocopherol transfer protein Rattus norvegicus 123-131 22042641-6 2012 In contrast to the dietary intake, alpha-tocopherol, which has the highest affinity for alpha-tocopherol transfer protein (alphaTTP), inhibited uptake of gamma-tocotrienol to tissues including adipose tissue after oral administration, suggesting that the affinities of tocopherol and tocotrienol for alphaTTP in the liver were the critical determinants of their uptake to peripheral tissues. Tocopherols 41-51 alpha tocopherol transfer protein Rattus norvegicus 300-308 23152872-0 2012 Engineering tocopherol selectivity in alpha-TTP: a combined in vitro/in silico study. Tocopherols 12-22 alpha tocopherol transfer protein Homo sapiens 38-47 21933153-8 2012 Tocopherols enhanced PKCalpha-C2 domain binding to PS-containing lipid vesicles. Tocopherols 0-11 protein kinase C alpha Homo sapiens 21-29 21933153-12 2012 Thus the tocopherols can function as agonists or antagonists for differential regulation of PKCalpha. Tocopherols 9-20 protein kinase C alpha Homo sapiens 92-100 22235772-3 2012 Results from simulated human digestion in vitro indicated that the bioaccessibility of total fatty acids and tocopherol decreased (62.7-8.3 and 59.7-19.4%, respectively) with the increasing concentration of iota-carrageenan. Tocopherols 109-119 proteasome subunit alpha type-6 Glycine max 207-211 22235772-4 2012 During the in vitro digestion procedure, iota-carrageenan affected physicochemical properties of the emulsions, thereby controlling the release of fatty acids and tocopherol. Tocopherols 163-173 proteasome subunit alpha type-6 Glycine max 41-45 23152872-1 2012 We present a combined in vitro/in silico study to determine the molecular origin of the selectivity of [Formula: see text]-tocopherol transfer protein ([Formula: see text]-TTP) towards [Formula: see text]-tocopherol. Tocopherols 123-133 ZFP36 ring finger protein Homo sapiens 172-175 23152872-2 2012 Molecular dynamics simulations combined to free energy perturbation calculations predict a binding free energy for [Formula: see text]-tocopherol to [Formula: see text]-TTP 8.26[Formula: see text]2.13 kcal mol[Formula: see text] lower than that of [Formula: see text]-tocopherol. Tocopherols 135-145 ZFP36 ring finger protein Homo sapiens 169-172 23152872-2 2012 Molecular dynamics simulations combined to free energy perturbation calculations predict a binding free energy for [Formula: see text]-tocopherol to [Formula: see text]-TTP 8.26[Formula: see text]2.13 kcal mol[Formula: see text] lower than that of [Formula: see text]-tocopherol. Tocopherols 268-278 ZFP36 ring finger protein Homo sapiens 169-172 23152872-3 2012 Our calculations show that [Formula: see text]-tocopherol binds to [Formula: see text]-TTP in a significantly distorted geometry as compared to that of the natural ligand. Tocopherols 47-57 ZFP36 ring finger protein Homo sapiens 87-90 23152872-5 2012 We propose a mutation, A156L, which significantly modifies the selectivity properties of [Formula: see text]-TTP towards the two tocopherols. Tocopherols 129-140 ZFP36 ring finger protein Homo sapiens 109-112 23152872-9 2012 The engineering of TTP mutants with modulating binding properties can have potential impact at industrial level for easier purification of single tocopherols from vitamin E mixtures coming from natural oils or synthetic processes. Tocopherols 146-157 ZFP36 ring finger protein Homo sapiens 19-22 23152872-10 2012 Moreover, the identification of a [Formula: see text]-tocopherol selective TTP offers the possibility to challenge the hypotheses for the evolutionary development of a mechanism for [Formula: see text]-tocopherol selection in omnivorous animals. Tocopherols 54-64 ZFP36 ring finger protein Homo sapiens 75-78 23152872-10 2012 Moreover, the identification of a [Formula: see text]-tocopherol selective TTP offers the possibility to challenge the hypotheses for the evolutionary development of a mechanism for [Formula: see text]-tocopherol selection in omnivorous animals. Tocopherols 202-212 ZFP36 ring finger protein Homo sapiens 75-78 22815910-13 2012 These tocopherols regulated ICAM-1 activation of PKCalpha without altering the upstream signal ERK1/2. Tocopherols 6-17 intercellular adhesion molecule 1 Homo sapiens 28-34 22815910-13 2012 These tocopherols regulated ICAM-1 activation of PKCalpha without altering the upstream signal ERK1/2. Tocopherols 6-17 protein kinase C alpha Homo sapiens 49-57 21550107-0 2011 Effect of tocopherol supplementation on serum 8-epi-prostaglandin F2 alpha and adiponectin concentrations, and mRNA expression of PPARgamma and related genes in ovine placenta and uterus. Tocopherols 10-20 adiponectin, C1Q and collagen domain containing Homo sapiens 79-90 21883249-1 2011 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is a very important enzyme in tocopherol biosynthesis in all photosynthetic organisms. Tocopherols 91-101 uncharacterized protein Chlamydomonas reinhardtii 0-34 21883249-1 2011 gamma-Tocopherol methyltransferase (gamma-TMT) (EC 2.1.1.95) is a very important enzyme in tocopherol biosynthesis in all photosynthetic organisms. Tocopherols 91-101 uncharacterized protein Chlamydomonas reinhardtii 36-45 21550107-10 2011 In conclusion, oral supplementation of tocopherol during late gestation in ewes decreased isoprostane concentrations and increased adiponectin concentrations in the serum, and significantly affected PPARgamma- and ADIPQ-related genes in the utero-placental network. Tocopherols 39-49 adiponectin, C1Q and collagen domain containing Homo sapiens 131-142 21550107-10 2011 In conclusion, oral supplementation of tocopherol during late gestation in ewes decreased isoprostane concentrations and increased adiponectin concentrations in the serum, and significantly affected PPARgamma- and ADIPQ-related genes in the utero-placental network. Tocopherols 39-49 peroxisome proliferator activated receptor gamma Homo sapiens 199-208 21550107-10 2011 In conclusion, oral supplementation of tocopherol during late gestation in ewes decreased isoprostane concentrations and increased adiponectin concentrations in the serum, and significantly affected PPARgamma- and ADIPQ-related genes in the utero-placental network. Tocopherols 39-49 adiponectin, C1Q and collagen domain containing Homo sapiens 214-219 21550107-11 2011 Perhaps the pro-angiogenic tocopherol effect in the placental vascular network was via PPARgamma-mediated regulation of genes responsible for metabolism of glucose and fatty acid, as well as for angiogenesis. Tocopherols 27-37 peroxisome proliferator activated receptor gamma Homo sapiens 87-96 21348879-5 2011 This study also found that tocopherols dramatically enhanced adiponectin expression and that this effect was mediated through a PPARgamma-dependent process. Tocopherols 27-38 adiponectin, C1Q and collagen domain containing Homo sapiens 61-72 21780685-1 2011 In the blood serum of seventeen members of crews which participated in 14 orbital expeditions to the International Space Station with the duration of 125 to 217 days, during the pre-flight period and on the day of landing on the 1st, 7th and 14th days of the rehabilitation period (RP) the content of LPO products was determined, namely diene conjugates (DC), malon dialdehyde (MDA), shiffbases (SB) and the main lipid oxidant - tocopherol (TP). Tocopherols 429-439 lactoperoxidase Homo sapiens 301-304 21780685-1 2011 In the blood serum of seventeen members of crews which participated in 14 orbital expeditions to the International Space Station with the duration of 125 to 217 days, during the pre-flight period and on the day of landing on the 1st, 7th and 14th days of the rehabilitation period (RP) the content of LPO products was determined, namely diene conjugates (DC), malon dialdehyde (MDA), shiffbases (SB) and the main lipid oxidant - tocopherol (TP). Tocopherols 441-443 lactoperoxidase Homo sapiens 301-304 21550990-4 2011 We examined the roles that NPC1/2 proteins play in the intracellular trafficking of tocopherol. Tocopherols 84-94 NPC intracellular cholesterol transporter 1 Homo sapiens 27-31 21550990-6 2011 In vivo, tocopherol significantly accumulated in murine Npc1-null and Npc2-null livers, Npc2-null cerebella, and Npc1-null cerebral cortices. Tocopherols 9-19 NPC intracellular cholesterol transporter 1 Mus musculus 56-60 21550990-6 2011 In vivo, tocopherol significantly accumulated in murine Npc1-null and Npc2-null livers, Npc2-null cerebella, and Npc1-null cerebral cortices. Tocopherols 9-19 NPC intracellular cholesterol transporter 2 Mus musculus 70-74 21550990-6 2011 In vivo, tocopherol significantly accumulated in murine Npc1-null and Npc2-null livers, Npc2-null cerebella, and Npc1-null cerebral cortices. Tocopherols 9-19 NPC intracellular cholesterol transporter 2 Mus musculus 88-92 21550990-6 2011 In vivo, tocopherol significantly accumulated in murine Npc1-null and Npc2-null livers, Npc2-null cerebella, and Npc1-null cerebral cortices. Tocopherols 9-19 NPC intracellular cholesterol transporter 1 Mus musculus 113-117 21550990-7 2011 Plasma tocopherol levels were within the normal range in Npc1-null and Npc2-null mice, and in plasma samples from human NPC patients. Tocopherols 7-17 NPC intracellular cholesterol transporter 2 Mus musculus 71-75 21550990-7 2011 Plasma tocopherol levels were within the normal range in Npc1-null and Npc2-null mice, and in plasma samples from human NPC patients. Tocopherols 7-17 NPC intracellular cholesterol transporter 1 Homo sapiens 120-123 21550990-8 2011 The binding affinity of tocopherol to the purified sterol-binding domain of NPC1 and to purified NPC2 was significantly weaker than that of cholesterol (measurements kindly performed by R. Infante, University of Texas Southwestern Medical Center, Dallas, TX). Tocopherols 24-34 NPC intracellular cholesterol transporter 1 Homo sapiens 76-80 21550990-8 2011 The binding affinity of tocopherol to the purified sterol-binding domain of NPC1 and to purified NPC2 was significantly weaker than that of cholesterol (measurements kindly performed by R. Infante, University of Texas Southwestern Medical Center, Dallas, TX). Tocopherols 24-34 NPC intracellular cholesterol transporter 2 Homo sapiens 97-101 21093517-4 2011 Tocopherol, an antioxidant used as positive control, had similar effect at 10 muM to SCM198 1 muM. Tocopherols 0-10 latexin Homo sapiens 78-81 21641454-0 2011 Repeatability in column preparation of a reversed-phase C18 monolith and its application to separation of tocopherol homologues. Tocopherols 106-116 Bardet-Biedl syndrome 9 Homo sapiens 56-59 21641454-6 2011 Usually tocopherol homologues cannot be completely separated by conventional reversed-phase C8- or C18-packed bed or C18-silica based monolithic columns. Tocopherols 8-18 Bardet-Biedl syndrome 9 Homo sapiens 99-102 21641454-6 2011 Usually tocopherol homologues cannot be completely separated by conventional reversed-phase C8- or C18-packed bed or C18-silica based monolithic columns. Tocopherols 8-18 Bardet-Biedl syndrome 9 Homo sapiens 117-120 21348879-5 2011 This study also found that tocopherols dramatically enhanced adiponectin expression and that this effect was mediated through a PPARgamma-dependent process. Tocopherols 27-38 peroxisome proliferator activated receptor gamma Homo sapiens 128-137 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Tocopherols 186-197 interleukin 6 Homo sapiens 20-24 20401738-0 2011 Simultaneous expression of Arabidopsis rho-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content. Tocopherols 143-153 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 39-76 20401738-2 2011 Two Arabidopsis cDNA clones corresponding to rho-hydroxyphenylpyruvate dioxygenase (HPPD) and 2-methyl-6-phytylplastoquinol methyltransferase (MPBQ MT) were constitutively expressed in corn to further characterize the pathway and increase the kernel tocopherol content. Tocopherols 250-260 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 45-82 20401738-2 2011 Two Arabidopsis cDNA clones corresponding to rho-hydroxyphenylpyruvate dioxygenase (HPPD) and 2-methyl-6-phytylplastoquinol methyltransferase (MPBQ MT) were constitutively expressed in corn to further characterize the pathway and increase the kernel tocopherol content. Tocopherols 250-260 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 84-88 21110980-2 2011 Revealing the molecular mechanisms by which alpha-TTP associates with membranes is thought to be critical to understanding its function and role in the secretion of tocopherol from hepatocytes into the circulation. Tocopherols 165-175 alpha tocopherol transfer protein Homo sapiens 44-53 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Tocopherols 325-336 interleukin 6 Homo sapiens 20-24 21609530-6 2011 Moreover, combination of mixed-tocopherols and EPA could also significantly increase SOD activity and decrease PKC activity (all P < 0.05). Tocopherols 31-42 superoxide dismutase 1 Homo sapiens 85-88 21609530-8 2011 CONCLUSION: Combined mixed-tocopherols + EPA use enhanced the inhibiting effects on the secretion of 8-OHDG and IL-6 in oxLDL stimulated HUVECs which might be linked with increased SOD activity and reduced p-PKC activity. Tocopherols 27-38 interleukin 6 Homo sapiens 112-116 21609530-8 2011 CONCLUSION: Combined mixed-tocopherols + EPA use enhanced the inhibiting effects on the secretion of 8-OHDG and IL-6 in oxLDL stimulated HUVECs which might be linked with increased SOD activity and reduced p-PKC activity. Tocopherols 27-38 superoxide dismutase 1 Homo sapiens 181-184 21223386-10 2011 Consistent with its in vitro substrate properties, barley HGGT generated a mixture of tocotrienols and tocopherols when expressed in the vitamin E-null vte2-1 mutant lacking a functional HPT. Tocopherols 103-114 Homogentisate geranylgeranyltransferase Hordeum vulgare 58-62 20149624-8 2010 Finally, tocopherols significantly reduced ABCA1 mRNA levels in Caco-2 cells. Tocopherols 9-20 ATP binding cassette subfamily A member 1 Homo sapiens 43-48 20826775-3 2010 We hypothesized that overexpression of the tocopherol transfer protein (TTP), a vitamin E-binding protein that regulates tocopherol status, will sensitize prostate cancer cells to the anti-proliferative actions of the vitamin. Tocopherols 43-53 SH3 domain binding protein 4 Homo sapiens 72-75 20828164-8 2010 Cell fractionation studies showed that TTP is distributed between the cytosolic and membranous organelle fraction, and that tocopherol induced the translocation of some TTP from the cytosol to the organelle fraction. Tocopherols 124-134 alpha tocopherol transfer protein Homo sapiens 169-172 20861217-1 2010 Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine. Tocopherols 90-101 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 6-25 20861217-1 2010 Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine. Tocopherols 90-101 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 27-33 20861217-1 2010 Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine. Tocopherols 103-106 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 6-25 20861217-1 2010 Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine. Tocopherols 103-106 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 27-33 20837525-3 2010 To investigate PC-8 function in vivo, we combined the Arabidopsis vte1 mutation that eliminates tocopherols and PC-8 and causes the accumulation of 2,3-dimethyl-6-phytyl-1,4-benzoquinol (DMPBQ), a redox-active tocopherol precursor, and the vte2 mutation that eliminates tocopherols without affecting PC-8. Tocopherols 96-107 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 66-70 20837525-3 2010 To investigate PC-8 function in vivo, we combined the Arabidopsis vte1 mutation that eliminates tocopherols and PC-8 and causes the accumulation of 2,3-dimethyl-6-phytyl-1,4-benzoquinol (DMPBQ), a redox-active tocopherol precursor, and the vte2 mutation that eliminates tocopherols without affecting PC-8. Tocopherols 96-106 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 66-70 20149624-9 2010 We conclude that tocopherols impair the endogenous synthesis and apo-AI-mediated secretion of cholesterol in Caco-2 cells. Tocopherols 17-28 apolipoprotein A1 Homo sapiens 65-71 20837525-4 2010 The vte2 vte1 double mutant lacks tocopherols, PC-8, and DMPBQ, and exhibits the most severe physiological and biochemical phenotypes of any tocochromanol-affected genotype isolated to date, most notably a severe seedling developmental phenotype associated with massive lipid oxidation initiated during seed desiccation and amplified during seed quiescence. Tocopherols 34-45 homogentisate phytyltransferase 1 Arabidopsis thaliana 4-8 20837525-4 2010 The vte2 vte1 double mutant lacks tocopherols, PC-8, and DMPBQ, and exhibits the most severe physiological and biochemical phenotypes of any tocochromanol-affected genotype isolated to date, most notably a severe seedling developmental phenotype associated with massive lipid oxidation initiated during seed desiccation and amplified during seed quiescence. Tocopherols 34-45 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 9-13 20837525-6 2010 Finally, the low relative fitness of vte2 vte1 demonstrates that tocopherols and PC-8 are in vivo lipid antioxidants essential for seed plant survival. Tocopherols 65-76 homogentisate phytyltransferase 1 Arabidopsis thaliana 37-41 20153623-11 2010 Since they did have higher hepatic alpha-CEHC concentrations, these data suggest metabolism was up-regulated in the AhR-null mice in order to maintain the hepatic tocopherol concentrations similar to those of wild-type mice. Tocopherols 163-173 aryl-hydrocarbon receptor Mus musculus 116-119 20837525-6 2010 Finally, the low relative fitness of vte2 vte1 demonstrates that tocopherols and PC-8 are in vivo lipid antioxidants essential for seed plant survival. Tocopherols 65-76 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 42-46 20337431-9 2010 The complete baseline separation of the tocopherol isomers was achieved using the Sil-poly(ODA-alt-OMI) phase. Tocopherols 40-50 STIL centriolar assembly protein Homo sapiens 82-85 20691023-4 2010 Subsequently, genes encoding Mn-superoxide dismutase (MSD1), catalase (CAT1), and homogentisate phytyltransferase (HPT1, responsible for the first committed reaction in the tocopherol biosynthesis pathway) were overexpressed in Arabidopsis under the control of the At2S3 promoter. Tocopherols 173-183 manganese superoxide dismutase 1 Arabidopsis thaliana 54-58 20691023-4 2010 Subsequently, genes encoding Mn-superoxide dismutase (MSD1), catalase (CAT1), and homogentisate phytyltransferase (HPT1, responsible for the first committed reaction in the tocopherol biosynthesis pathway) were overexpressed in Arabidopsis under the control of the At2S3 promoter. Tocopherols 173-183 catalase 2 Arabidopsis thaliana 61-69 20691023-4 2010 Subsequently, genes encoding Mn-superoxide dismutase (MSD1), catalase (CAT1), and homogentisate phytyltransferase (HPT1, responsible for the first committed reaction in the tocopherol biosynthesis pathway) were overexpressed in Arabidopsis under the control of the At2S3 promoter. Tocopherols 173-183 catalase 1 Arabidopsis thaliana 71-75 20691023-4 2010 Subsequently, genes encoding Mn-superoxide dismutase (MSD1), catalase (CAT1), and homogentisate phytyltransferase (HPT1, responsible for the first committed reaction in the tocopherol biosynthesis pathway) were overexpressed in Arabidopsis under the control of the At2S3 promoter. Tocopherols 173-183 homogentisate phytyltransferase 1 Arabidopsis thaliana 115-119 20061533-9 2010 The role of SR-BI in the intestinal absorption of other dietary lipids, including cholesterol, fatty acids, and tocopherols, implicates retinoid signaling in the regulation of lipid absorption more generally and has clinical implications for diseases associated with dyslipidemia. Tocopherols 112-123 scavenger receptor class B, member 1 Mus musculus 12-17 20345604-0 2010 Mutations of the ER to plastid lipid transporters TGD1, 2, 3 and 4 and the ER oleate desaturase FAD2 suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2. Tocopherols 163-173 trigalactosyldiacylglycerol 1 Arabidopsis thaliana 50-66 20345604-0 2010 Mutations of the ER to plastid lipid transporters TGD1, 2, 3 and 4 and the ER oleate desaturase FAD2 suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2. Tocopherols 163-173 fatty acid desaturase 2 Arabidopsis thaliana 96-100 20345604-0 2010 Mutations of the ER to plastid lipid transporters TGD1, 2, 3 and 4 and the ER oleate desaturase FAD2 suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2. Tocopherols 163-173 homogentisate phytyltransferase 1 Arabidopsis thaliana 191-195 20345604-1 2010 Previous studies with the tocopherol-deficient Arabidopsis thaliana vte2 mutant demonstrated an important role for tocopherols in the development of transfer cell walls and maintenance of photoassimilate export capacity during low-temperature (LT) adaptation. Tocopherols 26-36 homogentisate phytyltransferase 1 Arabidopsis thaliana 68-72 20345604-1 2010 Previous studies with the tocopherol-deficient Arabidopsis thaliana vte2 mutant demonstrated an important role for tocopherols in the development of transfer cell walls and maintenance of photoassimilate export capacity during low-temperature (LT) adaptation. Tocopherols 115-126 homogentisate phytyltransferase 1 Arabidopsis thaliana 68-72 20183830-5 2010 This is possibly related to an altered lipoprotein metabolism including increased alpha-TOH retention in LDL, a decreased expression of lipoprotein receptors and impaired cellular vitamin E delivery system, and a greater intracellular degradation of tocopherols in the apoE4 genotype. Tocopherols 250-261 apolipoprotein E Homo sapiens 269-274 20144585-2 2010 We have earlier reported that overexpression of the gamma-tocopherol methyl transferase (gamma-TMT) gene from Arabidopsis thaliana in transgenic Brassica juncea plants resulted in an over six-fold increase in the level of alpha-tocopherol, the most active form of all the tocopherols. Tocopherols 272-283 gamma-tocopherol methyltransferase Arabidopsis thaliana 52-87 20144585-2 2010 We have earlier reported that overexpression of the gamma-tocopherol methyl transferase (gamma-TMT) gene from Arabidopsis thaliana in transgenic Brassica juncea plants resulted in an over six-fold increase in the level of alpha-tocopherol, the most active form of all the tocopherols. Tocopherols 272-283 gamma-tocopherol methyltransferase Arabidopsis thaliana 89-98 19945507-6 2010 Only TS but not an equally antiprion active PKC inhibitor could be partially antagonized by substochiometric 1 nM rapamycin suggesting that there are pathways via mammalian target of rapamycin (mTOR) that interfere with tocopherol"s biological effects. Tocopherols 220-230 mechanistic target of rapamycin kinase Homo sapiens 163-192 19945507-6 2010 Only TS but not an equally antiprion active PKC inhibitor could be partially antagonized by substochiometric 1 nM rapamycin suggesting that there are pathways via mammalian target of rapamycin (mTOR) that interfere with tocopherol"s biological effects. Tocopherols 220-230 mechanistic target of rapamycin kinase Homo sapiens 194-198 19945507-7 2010 Interaction with the mTOR pathway is a yet undescribed characteristic of tocopherol derivatives, potentially significant for pathophysiological processes other than prion propagation. Tocopherols 73-83 mechanistic target of rapamycin kinase Homo sapiens 21-25 19833717-3 2009 We demonstrate here that adiponectin expression is induced in adipocytes after exposure to tocopherols via the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. Tocopherols 91-102 adiponectin, C1Q and collagen domain containing Mus musculus 25-36 19833717-3 2009 We demonstrate here that adiponectin expression is induced in adipocytes after exposure to tocopherols via the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. Tocopherols 91-102 peroxisome proliferator activated receptor gamma Mus musculus 111-159 19833717-3 2009 We demonstrate here that adiponectin expression is induced in adipocytes after exposure to tocopherols via the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. Tocopherols 91-102 peroxisome proliferator activated receptor gamma Mus musculus 161-170 19833717-7 2009 The induction of adiponectin by tocopherols seems to be PPARgamma dependent, because it was blocked by the specific antagonist GW9662. Tocopherols 32-43 adiponectin, C1Q and collagen domain containing Mus musculus 17-28 19833717-7 2009 The induction of adiponectin by tocopherols seems to be PPARgamma dependent, because it was blocked by the specific antagonist GW9662. Tocopherols 32-43 peroxisome proliferator activated receptor gamma Mus musculus 56-65 19833717-8 2009 Finally, we showed that intracellular concentrations of a PPARgamma endogenous ligand, 15-deoxy-Delta12,14-prostaglandin J2, increased after treatment with tocopherols in 3T3-L1 cells. Tocopherols 156-167 peroxisome proliferator activated receptor gamma Mus musculus 58-67 19903353-12 2009 Combining the pdx1.3 mutation with mutations affecting the level of "classical" quenchers of 1O2 (zeaxanthin, tocopherols) resulted in a highly photosensitive phenotype. Tocopherols 110-121 Aldolase-type TIM barrel family protein Arabidopsis thaliana 14-18 19331391-2 2009 Oxidations carried out at low tocopherol concentration gave only C-1 and C-5 conjugated diene hydroperoxides, while higher concentrations of the antioxidant resulted in formation of substantial amounts of the nonconjugated C-3 diene hydroperoxide. Tocopherols 30-40 heterogeneous nuclear ribonucleoprotein C Homo sapiens 65-76 19452524-9 2009 The associations between lutein and tocopherol and TP53 and KRAS2 mutations were modified by IL6 genotype. Tocopherols 36-46 tumor protein p53 Homo sapiens 51-55 19452524-9 2009 The associations between lutein and tocopherol and TP53 and KRAS2 mutations were modified by IL6 genotype. Tocopherols 36-46 KRAS proto-oncogene, GTPase Homo sapiens 60-65 19452524-9 2009 The associations between lutein and tocopherol and TP53 and KRAS2 mutations were modified by IL6 genotype. Tocopherols 36-46 interleukin 6 Homo sapiens 93-96 20387640-2 2009 This is the first report demonstrating that troglitazone and alpha-tocopherol C6, unlike a-tocopherol and pioglitazone substantially inhibited the activity of NAD(P)H:quinone oxidoreductase (DT-diaphorase) and this effect is increased with specific DT-diaphorase inhibitor, dicoumarol. Tocopherols 67-77 crystallin zeta Rattus norvegicus 167-189 20387640-2 2009 This is the first report demonstrating that troglitazone and alpha-tocopherol C6, unlike a-tocopherol and pioglitazone substantially inhibited the activity of NAD(P)H:quinone oxidoreductase (DT-diaphorase) and this effect is increased with specific DT-diaphorase inhibitor, dicoumarol. Tocopherols 67-77 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 191-204 20387640-2 2009 This is the first report demonstrating that troglitazone and alpha-tocopherol C6, unlike a-tocopherol and pioglitazone substantially inhibited the activity of NAD(P)H:quinone oxidoreductase (DT-diaphorase) and this effect is increased with specific DT-diaphorase inhibitor, dicoumarol. Tocopherols 67-77 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 249-262 19509159-0 2009 Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Tocopherols 6-17 peroxisome proliferator activated receptor gamma Homo sapiens 93-103 19509159-10 2009 Mixed tocopherols increased the expression of p21, p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors. Tocopherols 6-17 H3 histone pseudogene 16 Homo sapiens 46-49 19509159-10 2009 Mixed tocopherols increased the expression of p21, p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors. Tocopherols 6-17 dynactin subunit 6 Homo sapiens 51-54 19509159-10 2009 Mixed tocopherols increased the expression of p21, p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors. Tocopherols 6-17 caspase 3 Homo sapiens 56-119 19509159-10 2009 Mixed tocopherols increased the expression of p21, p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors. Tocopherols 6-17 AKT serine/threonine kinase 1 Homo sapiens 135-138 19258016-1 2009 Tocopherol biosynthesis was investigated in ein3-1, etr1-1 and eto1-1 mutants of Arabidopsis thaliana, which show a defect in ethylene signaling, perception and over-produce ethylene, respectively. Tocopherols 0-10 Ethylene insensitive 3 family protein Arabidopsis thaliana 44-48 19258016-1 2009 Tocopherol biosynthesis was investigated in ein3-1, etr1-1 and eto1-1 mutants of Arabidopsis thaliana, which show a defect in ethylene signaling, perception and over-produce ethylene, respectively. Tocopherols 0-10 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 52-58 19258016-1 2009 Tocopherol biosynthesis was investigated in ein3-1, etr1-1 and eto1-1 mutants of Arabidopsis thaliana, which show a defect in ethylene signaling, perception and over-produce ethylene, respectively. Tocopherols 0-10 tetratricopeptide repeat (TPR)-containing protein Arabidopsis thaliana 63-69 19447983-5 2009 Results showed that the accumulation of the tocopherol and lycopene into mixed micelles in MFGM-stabilized emulsions was around 2-fold greater than in emulsions stabilized with conventional milk proteins. Tocopherols 44-54 milk fat globule EGF and factor V/VIII domain containing Bos taurus 91-95 19264498-4 2009 The concentration of total tocopherol was up to 12-fold higher in outdoor growing wild type and vte4 plant lines than in plants grown under laboratory conditions. Tocopherols 27-37 gamma-tocopherol methyltransferase Arabidopsis thaliana 96-100 19115203-0 2009 Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. Tocopherols 6-16 translocating chain-associating membrane protein 1 Mus musculus 84-89 19115203-10 2009 Nrf2-a redox sensitive transcription factor known to mediate the expression of phase II detoxifying enzymes, was also significantly upregulated following treatment with gamma-T-enriched mixed tocopherol diet. Tocopherols 192-202 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 19115203-11 2009 Gamma-T-enriched mixed tocopherols significantly up-regulated the expression of Nrf2 and its related detoxifying and antioxidant enzymes thereby suppressing PIN and tumor development. Tocopherols 23-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 80-84 18662427-11 2009 These results suggest that apo C-III, CETP and hepatic lipase play a role in determining the plasma concentrations of tocopherols while hepatic lipase and I-FABP may modulate plasma concentrations of carotenoids. Tocopherols 118-129 cholesteryl ester transfer protein Homo sapiens 38-42 18662427-11 2009 These results suggest that apo C-III, CETP and hepatic lipase play a role in determining the plasma concentrations of tocopherols while hepatic lipase and I-FABP may modulate plasma concentrations of carotenoids. Tocopherols 118-129 lipase C, hepatic type Homo sapiens 47-61 18452591-4 2008 This method was used to study the response of wild-type Arabidopsis (Col) and the tocopherol biosynthetic mutants vte1, vte2 and vte4 during 12 h low- and high-light treatments (LL and HL, 90 and 1500 mumol photon m(-2) sec(-1), respectively) and a subsequent 12 h dark recovery period. Tocopherols 82-92 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 114-118 18709655-1 2008 Tocopherols (vitamin E) are potent antioxidants as well as modulators of enzymes involved in signal transduction, like nitric oxide synthase (NOS). Tocopherols 0-11 nitric oxide synthase 1, neuronal Mus musculus 119-140 18458085-2 2008 Body-wide distribution of tocopherol is regulated by the hepatic alpha-tocopherol transfer protein (alphaTTP), which stimulates secretion of the vitamin from hepatocytes to circulating lipoproteins. Tocopherols 26-36 alpha tocopherol transfer protein Homo sapiens 65-98 18458085-2 2008 Body-wide distribution of tocopherol is regulated by the hepatic alpha-tocopherol transfer protein (alphaTTP), which stimulates secretion of the vitamin from hepatocytes to circulating lipoproteins. Tocopherols 26-36 alpha tocopherol transfer protein Homo sapiens 100-108 18458085-4 2008 Using a fluorescence energy transfer methodology, we found that the rate of tocopherol transfer from lipid vesicles to alphaTTP increases with increasing alphaTTP concentration. Tocopherols 76-86 alpha tocopherol transfer protein Homo sapiens 119-127 18458085-4 2008 Using a fluorescence energy transfer methodology, we found that the rate of tocopherol transfer from lipid vesicles to alphaTTP increases with increasing alphaTTP concentration. Tocopherols 76-86 alpha tocopherol transfer protein Homo sapiens 154-162 18458085-8 2008 Some naturally occurring mutations in alphaTTP that cause the hereditary disorder ataxia with vitamin E deficiency diminish the effect of tocopherol on the protein-membrane association, suggesting a possible mechanism for the accompanying pathology. Tocopherols 138-148 alpha tocopherol transfer protein Homo sapiens 38-46 18452591-4 2008 This method was used to study the response of wild-type Arabidopsis (Col) and the tocopherol biosynthetic mutants vte1, vte2 and vte4 during 12 h low- and high-light treatments (LL and HL, 90 and 1500 mumol photon m(-2) sec(-1), respectively) and a subsequent 12 h dark recovery period. Tocopherols 82-92 homogentisate phytyltransferase 1 Arabidopsis thaliana 120-124 18452591-4 2008 This method was used to study the response of wild-type Arabidopsis (Col) and the tocopherol biosynthetic mutants vte1, vte2 and vte4 during 12 h low- and high-light treatments (LL and HL, 90 and 1500 mumol photon m(-2) sec(-1), respectively) and a subsequent 12 h dark recovery period. Tocopherols 82-92 gamma-tocopherol methyltransferase Arabidopsis thaliana 129-133 18959027-1 2008 The effect of inactivation of VTE1 and VTE4 genes, encoding enzymes involved in tocopherol biosynthesis, on concentrations of chlorophylls, carotenoids, anthocyanins and activity of catalase and guaiacol peroxidase in Arabidopsis thaliana under salt stress conditions were studied. Tocopherols 80-90 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 30-34 18395016-8 2008 Serum tocopherol was higher in apoE deficient animals and remained higher than wild type during E deficiency. Tocopherols 6-16 apolipoprotein E Mus musculus 31-35 18395016-10 2008 Our current and previous observations strongly suggest that apoE has an important role in modulating tocopherol concentrations in brain, probably acting in concert with other proteins as well. Tocopherols 101-111 apolipoprotein E Mus musculus 60-64 18959027-1 2008 The effect of inactivation of VTE1 and VTE4 genes, encoding enzymes involved in tocopherol biosynthesis, on concentrations of chlorophylls, carotenoids, anthocyanins and activity of catalase and guaiacol peroxidase in Arabidopsis thaliana under salt stress conditions were studied. Tocopherols 80-90 gamma-tocopherol methyltransferase Arabidopsis thaliana 39-43 18022315-0 2008 RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Tocopherols 9-20 TNF receptor superfamily member 10b Homo sapiens 80-96 18524327-8 2008 The presence of a monosaturated fatty acid (oleic acid) and the high concentrations of micronutrients (a tocopherol and retinol) in RBD red palm oil, influence favorably the lipid profile of rats with induced hyperlipidemia. Tocopherols 105-115 calcium voltage-gated channel subunit alpha1 D Rattus norvegicus 132-135 18503702-9 2008 Tocopherol administration induced a significant decrease in TAS and SOD activity. Tocopherols 0-10 superoxide dismutase 1 Homo sapiens 68-71 18022315-0 2008 RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Tocopherols 9-20 TNF receptor superfamily member 10b Homo sapiens 98-101 19005980-9 2008 The rank order of VEGF protein secretion inhibitory potency was genistein > kaempferol > apigenin > quercetin > tocopherol > luteolin > cisplatin > rutin > naringin > taxifolin. Tocopherols 124-134 vascular endothelial growth factor A Homo sapiens 18-22 17965177-6 2007 Moreover, pkp1 contains less tocopherol and chlorophyll than the wild type. Tocopherols 29-39 Pyruvate kinase family protein Arabidopsis thaliana 10-14 17569077-2 2007 The previously isolated pds2 mutant from Arabidopsis was deficient in tocopherol and plastoquinone accumulation, and the biochemical phenotype of this mutant could not be reversed by externally applied homogentisate, suggesting a later step in tocopherol and/or plastoquinone biosynthesis had been disrupted. Tocopherols 70-80 homogentisate prenyltransferase Arabidopsis thaliana 24-28 17619201-5 2007 Quantification of NOx in leaves revealed that the vte4 mutant in comparison to wild type and the mutant vte1, which does not contain any tocopherol, has a reduced NOx concentration. Tocopherols 137-147 gamma-tocopherol methyltransferase Arabidopsis thaliana 50-54 17932304-7 2007 The tocopherol-deficient ch1 vte1 double mutant was as sensitive to high light as ch1 npq1, and the triple mutant ch1 npq1 vte1 exhibited an extreme sensitivity to photooxidative stress, indicating that zeaxanthin and tocopherols have cumulative effects. Tocopherols 4-14 Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein Arabidopsis thaliana 25-28 17569077-2 2007 The previously isolated pds2 mutant from Arabidopsis was deficient in tocopherol and plastoquinone accumulation, and the biochemical phenotype of this mutant could not be reversed by externally applied homogentisate, suggesting a later step in tocopherol and/or plastoquinone biosynthesis had been disrupted. Tocopherols 244-254 homogentisate prenyltransferase Arabidopsis thaliana 24-28 17569077-3 2007 Recently, the protein encoded by At3g11950 (AtHST) was shown to condense homogentisate with solanesyl diphosphate (SDP), the substrate for plastoquinone synthesis, but not phytyl diphosphate (PDP), the substrate for tocopherol biosynthesis. Tocopherols 216-226 ARM repeat superfamily protein Arabidopsis thaliana 44-49 17608946-1 2007 BACKGROUND: Stimulation of C3H 10T1/2 murine fibroblasts with interferon-gamma(IFN) and bacterial lipopolysaccharide (LPS) generates reactive oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol oxidation. Tocopherols 214-224 interferon gamma Mus musculus 62-83 17608946-4 2007 Inhibition of nitric oxide (NO) synthesis by a specific inhibitor of inducible NO synthase (iNOS) increased both intracellular alpha-tocopherol and gamma-tocopherol concentrations, but did not significantly alter the reduction in media tocopherol levels caused by IFN/LPS treatment. Tocopherols 133-143 nitric oxide synthase 2, inducible Mus musculus 69-90 17337591-6 2007 We have also demonstrated that the reduction of I(to) density induced by TNF-alpha was prevented by the selective inducible nitric oxide synthase (iNOS) inhibitor 1400-W, the protein synthesis inhibitor cycloheximide, the antioxidant tocopherol, and the superoxide dismutase mimetic manganese(III) tetrakis (4-benzoic acid) porphyrin. Tocopherols 234-244 tumor necrosis factor Rattus norvegicus 73-82 17978586-2 2007 To increase tocopherol content by increasing total flux to the tocopherol biosynthetic pathway, genes encoding Arabidopsis homogentisate phytyltransferase (HPT/V-TE2) and tocopherol cyclase (TC/VTE1) were constitutively overexpressed in lettuce (Lactuca sativa L.). Tocopherols 12-22 homogentisate phytyltransferase 1 Arabidopsis thaliana 160-165 17560088-6 2007 This could be due to (a) the lower levels of alpha tocopherol in apoE-deficient brain and (b) reductions in the clearance and transport of tocopherol (possibly mediated by apoE). Tocopherols 51-61 apolipoprotein E Mus musculus 65-69 17560088-7 2007 Tocopherol uptake by hippocampus was unusual since it was lower in apoE deficiency whether the data were expressed as specific activity or per mg of protein. Tocopherols 0-10 apolipoprotein E Mus musculus 67-71 17337591-6 2007 We have also demonstrated that the reduction of I(to) density induced by TNF-alpha was prevented by the selective inducible nitric oxide synthase (iNOS) inhibitor 1400-W, the protein synthesis inhibitor cycloheximide, the antioxidant tocopherol, and the superoxide dismutase mimetic manganese(III) tetrakis (4-benzoic acid) porphyrin. Tocopherols 234-244 nitric oxide synthase 2 Rattus norvegicus 114-145 17337591-6 2007 We have also demonstrated that the reduction of I(to) density induced by TNF-alpha was prevented by the selective inducible nitric oxide synthase (iNOS) inhibitor 1400-W, the protein synthesis inhibitor cycloheximide, the antioxidant tocopherol, and the superoxide dismutase mimetic manganese(III) tetrakis (4-benzoic acid) porphyrin. Tocopherols 234-244 nitric oxide synthase 2 Rattus norvegicus 147-151 17927505-9 2007 Dietary administration of mixed tocopherols significantly suppressed mammary tumor growth (P < 0.05) and proliferating cell nuclear antigen (P < 0.01) and also moderately suppressed tumor multiplicity. Tocopherols 32-43 proliferating cell nuclear antigen Rattus norvegicus 108-142 17284776-1 2007 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial omega-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E. Tocopherols 107-118 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 6-25 17284776-1 2007 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial omega-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E. Tocopherols 107-118 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 27-33 25168137-6 2007 This region also encompasses the proton sensor E306 that is required for the activation of TREK-1 by cytosolic acidosis. Tocopherols 47-51 potassium two pore domain channel subfamily K member 2 Homo sapiens 91-97 25168137-7 2007 Protonation of E306 increases channel-phospholipid interaction leading to TREK-1 opening without direct-mechanical stimulation. Tocopherols 15-19 potassium two pore domain channel subfamily K member 2 Homo sapiens 74-80 17284776-11 2007 These results indicate that CYP4F2-mediated tocopherol-omega-hydroxylation is a central feature underlying the different biological half-lives, and therefore biopotencies, of the tocopherols and tocotrienols. Tocopherols 44-54 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 28-34 17284776-11 2007 These results indicate that CYP4F2-mediated tocopherol-omega-hydroxylation is a central feature underlying the different biological half-lives, and therefore biopotencies, of the tocopherols and tocotrienols. Tocopherols 179-190 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 28-34 17342287-10 2007 CONCLUSION: Repeated heating of soy oil destroyed the tocopherols causing raised serum IL-6 and osteocalcin levels, leading to increased bone resorption and osteoporosis in the long term. Tocopherols 54-65 interleukin 6 Rattus norvegicus 87-91 17342287-10 2007 CONCLUSION: Repeated heating of soy oil destroyed the tocopherols causing raised serum IL-6 and osteocalcin levels, leading to increased bone resorption and osteoporosis in the long term. Tocopherols 54-65 bone gamma-carboxyglutamate protein Rattus norvegicus 96-107 17194769-2 2006 Two tocopherol-deficient mutant loci in Arabidopsis thaliana were used to examine the functions of tocopherols in seedlings: vitamin e1 (vte1), which accumulates the pathway intermediate 2,3-dimethyl-5-phytyl-1,4-benzoquinone (DMPBQ); and vte2, which lacks all tocopherols and pathway intermediates. Tocopherols 4-14 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 137-141 17628171-3 2007 The alpha-tocopherol transfer protein (TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E between membrane vesicles in vitro and facilitates the secretion of tocopherol from hepatocytes. Tocopherols 10-20 alpha tocopherol transfer protein Homo sapiens 39-42 17628173-9 2007 The step-function difference between arylating and nonarylating tocopherol quinones is conceivably the basis for distinct biological properties of parent tocopherols, including the epigenetic modification of a histone thiol, the ceramide pathway, natriuresis, and the activity of COX-2, NF-kappaB, PPARgamma, and cyclin. Tocopherols 154-165 mitochondrially encoded cytochrome c oxidase II Homo sapiens 280-285 17628173-9 2007 The step-function difference between arylating and nonarylating tocopherol quinones is conceivably the basis for distinct biological properties of parent tocopherols, including the epigenetic modification of a histone thiol, the ceramide pathway, natriuresis, and the activity of COX-2, NF-kappaB, PPARgamma, and cyclin. Tocopherols 154-165 peroxisome proliferator activated receptor gamma Homo sapiens 298-307 17628173-9 2007 The step-function difference between arylating and nonarylating tocopherol quinones is conceivably the basis for distinct biological properties of parent tocopherols, including the epigenetic modification of a histone thiol, the ceramide pathway, natriuresis, and the activity of COX-2, NF-kappaB, PPARgamma, and cyclin. Tocopherols 154-165 proliferating cell nuclear antigen Homo sapiens 313-319 17194769-2 2006 Two tocopherol-deficient mutant loci in Arabidopsis thaliana were used to examine the functions of tocopherols in seedlings: vitamin e1 (vte1), which accumulates the pathway intermediate 2,3-dimethyl-5-phytyl-1,4-benzoquinone (DMPBQ); and vte2, which lacks all tocopherols and pathway intermediates. Tocopherols 99-110 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 137-141 17194769-2 2006 Two tocopherol-deficient mutant loci in Arabidopsis thaliana were used to examine the functions of tocopherols in seedlings: vitamin e1 (vte1), which accumulates the pathway intermediate 2,3-dimethyl-5-phytyl-1,4-benzoquinone (DMPBQ); and vte2, which lacks all tocopherols and pathway intermediates. Tocopherols 261-272 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 137-141 17194769-7 2006 Together, these results establish that tocopherols in wild-type plants or DMPBQ in vte1 plants limit nonenzymatic lipid peroxidation during germination and early seedling development, thereby preventing the inappropriate activation of transcriptional and biochemical defense responses. Tocopherols 39-50 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 83-87 16702307-8 2006 Among the tocopherol derivatives, alpha-TOS (0.1 micromol/L) was the most effective in reducing VEGF release. Tocopherols 10-20 vascular endothelial growth factor A Homo sapiens 96-100 17087496-10 2006 Moreover, our analyses suggest a role of NinaD-I in tocopherol metabolism. Tocopherols 52-62 neither inactivation nor afterpotential D Drosophila melanogaster 41-46 16941498-8 2006 Tocopherol levels in these latter regions of apoE-deficient animals increased to control levels during the study. Tocopherols 0-10 apolipoprotein E Mus musculus 45-49 17012603-2 2006 Surprisingly subtle differences were observed between the tocopherol-deficient vte2 mutant and the wild type during high-light, salinity, and drought stresses. Tocopherols 58-68 homogentisate phytyltransferase 1 Arabidopsis thaliana 79-83 16702307-10 2006 Inhibition of VEGF release by flavonoids, tocopherols, and lovastatin in these models of neoplastic cells suggests a novel mechanism for mammary cancer prevention. Tocopherols 42-53 vascular endothelial growth factor A Homo sapiens 14-18 16819822-1 2006 Tocopherol transfer protein (TTP) regulates vitamin E status by facilitating the secretion of tocopherol from liver to circulating lipoproteins. Tocopherols 94-104 ZFP36 ring finger protein Homo sapiens 0-27 16819822-1 2006 Tocopherol transfer protein (TTP) regulates vitamin E status by facilitating the secretion of tocopherol from liver to circulating lipoproteins. Tocopherols 94-104 ZFP36 ring finger protein Homo sapiens 29-32 16819822-3 2006 The molecular mechanisms by which TTP facilitates tocopherol secretion are presently unknown. Tocopherols 50-60 ZFP36 ring finger protein Homo sapiens 34-37 16819822-5 2006 We showed further that TTP is localized to late endocytic vesicles and that it facilitates the intracellular trafficking of tocopherol from lysosomes to the plasma membrane. Tocopherols 124-134 ZFP36 ring finger protein Homo sapiens 23-26 16384840-3 2006 We hypothesized that supplementation with antioxidant vitamins C (ascorbic acid) and E (tocopherol) would attenuate the exercise-induced increase of HSP72 in the skeletal muscle and in the circulation. Tocopherols 88-98 heat shock protein family A (Hsp70) member 1A Homo sapiens 149-154 16408209-3 2006 The first committed reaction in tocopherol biosynthesis is the condensation of homogentisic acid (HGA) with phytyldiphosphate or geranylgeranyldiphosphate, catalyzed by the homogentisate phytyltransferase (VTE2) or by the homogentisate geranylgeranyl transferase (HGGT). Tocopherols 32-42 homogentisate phytyltransferase 1 Arabidopsis thaliana 206-210 16408209-6 2006 Seed-specific expression of VTE2-2 in Arabidopsis resulted in increased seed-tocopherol levels, similar to the transgenic expression of VTE2-1. Tocopherols 77-87 homogentisate phytyltransferase 1 Arabidopsis thaliana 28-34 16408209-6 2006 Seed-specific expression of VTE2-2 in Arabidopsis resulted in increased seed-tocopherol levels, similar to the transgenic expression of VTE2-1. Tocopherols 77-87 homogentisate phytyltransferase 1 Arabidopsis thaliana 28-32 16516856-5 2006 The tocopherols inhibited glioma cell-binding to fibronectin where gamma-tocopherol treatment induced glioma cell migration. Tocopherols 4-15 fibronectin 1 Homo sapiens 49-60 16414959-4 2006 We demonstrate specific plastoglobule association of members of the plastid lipid-associated proteins/fibrillin family as well as known metabolic enzymes, including the tocopherol cyclase (VTE1), a key enzyme of tocopherol (vitamin E) synthesis. Tocopherols 169-179 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 189-193 16516856-6 2006 Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin alpha5 and beta1 expression. Tocopherols 130-141 integrin subunit alpha 5 Homo sapiens 195-210 16516856-6 2006 Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin alpha5 and beta1 expression. Tocopherols 130-141 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 215-220 16542571-2 2006 In this study, PLS-1 was applied to matrices made up of fluorescence excitation and emission spectra (EEM) and with fluorescence excitation, emission, and synchronous spectra (EESM) of tocopherols dissolved in hexane: diethyl ether (70:30 v/v). Tocopherols 185-196 plastin 1 Homo sapiens 15-20 16024914-8 2005 Once internalized, tocopherol arrives within approximately 30 min at intracellular vesicular organelles, where it co-localizes with TTP, and with a marker of the lysosomal compartment (LAMP1), before being transported to the plasma membrane in a TTP-dependent manner. Tocopherols 19-29 lysosomal associated membrane protein 1 Homo sapiens 185-190 16417629-10 2006 RRR-gamma-tocopherol treatment resulted in cleavage of PARP, caspase 3, 7, and 8, but not caspase 9. Tocopherols 10-20 collagen type XI alpha 2 chain Homo sapiens 55-59 16417629-10 2006 RRR-gamma-tocopherol treatment resulted in cleavage of PARP, caspase 3, 7, and 8, but not caspase 9. Tocopherols 10-20 caspase 3 Homo sapiens 61-70 16361393-1 2006 We report the identification and characterization of a low tocopherol Arabidopsis thaliana mutant, vitamin E pathway gene5-1 (vte5-1), with seed tocopherol levels reduced to 20% of the wild type. Tocopherols 59-69 phytol kinase 1 VTE5 Arabidopsis thaliana 126-130 16361393-1 2006 We report the identification and characterization of a low tocopherol Arabidopsis thaliana mutant, vitamin E pathway gene5-1 (vte5-1), with seed tocopherol levels reduced to 20% of the wild type. Tocopherols 145-155 phytol kinase 1 VTE5 Arabidopsis thaliana 126-130 16361393-4 2006 A knockout mutation of the Synechocystis sp PCC 6803 VTE5 homolog slr1652 reduced Synechocystis tocopherol levels by 50% or more. Tocopherols 96-106 phytol kinase 1 VTE5 Arabidopsis thaliana 53-57 16361393-8 2006 The phenotype of the vte5-1 mutant is consistent with the hypothesis that chlorophyll degradation-derived phytol serves as an important intermediate in seed tocopherol synthesis and forces reevaluation of the role of geranylgeranyl diphosphate reductase in tocopherol biosynthesis. Tocopherols 157-167 phytol kinase 1 VTE5 Arabidopsis thaliana 21-25 16361393-8 2006 The phenotype of the vte5-1 mutant is consistent with the hypothesis that chlorophyll degradation-derived phytol serves as an important intermediate in seed tocopherol synthesis and forces reevaluation of the role of geranylgeranyl diphosphate reductase in tocopherol biosynthesis. Tocopherols 257-267 phytol kinase 1 VTE5 Arabidopsis thaliana 21-25 15665245-3 2005 Tocopherol cyclase (VTE1) catalyzes the penultimate step of tocopherol synthesis, and an Arabidopsis (Arabidopsis thaliana) mutant deficient in VTE1 (vte1) is totally devoid of tocopherol. Tocopherols 60-70 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 20-24 16009347-4 2005 In addition, (+)-alpha-tocopherol also elevated the pro-caspase-3 protein level and mRNA expression in a time- and dose-dependent manner, while other tocopherol analogues showed no effect. Tocopherols 23-33 caspase 3 Homo sapiens 52-65 15665245-5 2005 Expression studies demonstrated that indeed VTE1 is a major limiting factor of tocopherol synthesis in leaves. Tocopherols 79-89 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 44-48 16008101-0 2005 Tocopherol content and activities of tyrosine aminotransferase and cystine lyase in Arabidopsis under stress conditions. Tocopherols 0-10 lyase Arabidopsis thaliana 75-80 15665245-3 2005 Tocopherol cyclase (VTE1) catalyzes the penultimate step of tocopherol synthesis, and an Arabidopsis (Arabidopsis thaliana) mutant deficient in VTE1 (vte1) is totally devoid of tocopherol. Tocopherols 60-70 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 144-148 15665245-6 2005 Tocopherol deficiency in vte1 resulted in the increase in ascorbate and glutathione, whereas accumulation of tocopherol in VTE1 overexpressing plants led to a decrease in ascorbate and glutathione. Tocopherols 0-10 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 25-29 15665245-3 2005 Tocopherol cyclase (VTE1) catalyzes the penultimate step of tocopherol synthesis, and an Arabidopsis (Arabidopsis thaliana) mutant deficient in VTE1 (vte1) is totally devoid of tocopherol. Tocopherols 60-70 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 150-154 15665245-6 2005 Tocopherol deficiency in vte1 resulted in the increase in ascorbate and glutathione, whereas accumulation of tocopherol in VTE1 overexpressing plants led to a decrease in ascorbate and glutathione. Tocopherols 109-119 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 123-127 15665245-3 2005 Tocopherol cyclase (VTE1) catalyzes the penultimate step of tocopherol synthesis, and an Arabidopsis (Arabidopsis thaliana) mutant deficient in VTE1 (vte1) is totally devoid of tocopherol. Tocopherols 177-187 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 20-24 15665245-3 2005 Tocopherol cyclase (VTE1) catalyzes the penultimate step of tocopherol synthesis, and an Arabidopsis (Arabidopsis thaliana) mutant deficient in VTE1 (vte1) is totally devoid of tocopherol. Tocopherols 177-187 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 150-154 15665245-4 2005 Overexpression of VTE1 resulted in an increase in total tocopherol of at least 7-fold in leaves, and a dramatic shift from alpha-tocopherol to gamma-tocopherol. Tocopherols 56-66 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 18-22 15577940-4 2005 This region also encompasses the proton sensor E306 that is required for activation of TREK-1 by cytosolic acidosis. Tocopherols 47-51 potassium two pore domain channel subfamily K member 2 Homo sapiens 87-93 15694191-3 2005 AIM: The aim of the study was to correlate serum levels of tocopherols with serum copper and ceruloplasmin and clinical status of these patients. Tocopherols 59-70 ceruloplasmin Homo sapiens 93-106 15577940-5 2005 Protonation of E306 drastically tightens channel-phospholipid interaction and leads to TREK-1 opening at atmospheric pressure. Tocopherols 15-19 potassium two pore domain channel subfamily K member 2 Homo sapiens 87-93 15763493-4 2005 Membrane stabilisation by tocopherol or prevention of early ALAS induction by cycloheximide prevented both mitochondrial heme accumulation and increase of TDO heme saturation. Tocopherols 26-36 tryptophan 2,3-dioxygenase Rattus norvegicus 155-158 15546721-0 2004 Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells. Tocopherols 0-10 tumor necrosis factor Homo sapiens 64-73 15668660-6 2005 Bivariate analysis showed a significant inverse association between CRP and many nutrients (e.g., carbohydrates, proteins, lipids, thiamine, pyridoxine, tocopherol, and folate), but multiple-regression analysis indicated that only the effect of dietary folate intake was not dependent on other factors. Tocopherols 153-163 C-reactive protein Homo sapiens 68-71 15753130-10 2004 Liver microsomes and recombinant CYP4F2 both exhibited substrate preference for gamma-TOH over alpha-TOH, and recent studies show that tocotrienols are catabolized more extensively than the corresponding tocopherols. Tocopherols 204-215 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 33-39 15385541-6 2004 In the presence of PKC or PP2A inhibitors, the reduction of PKB phosphorylation by tocopherols was still observed, thus excluding the direct involvement of these enzymes. Tocopherols 83-94 protein phosphatase 2 phosphatase activator Homo sapiens 26-30 15385541-9 2004 Thus, the tocopherols interfere with PKB phosphorylation and reduce proliferation of HMC-1 cells, possibly by modulating either phosphatidylinositol 3-kinase, a kinase phosphorylating PKB (PDK1/2), or a phosphatase that dephosphorylates it. Tocopherols 10-21 pyruvate dehydrogenase kinase 1 Homo sapiens 189-195 15544481-9 2004 Antioxidants including vitamin A (retinoids), vitamin C (ascorbic acid) and vitamin E (tocopherols) show promise for reversal of PKC activation. Tocopherols 87-98 proline rich transmembrane protein 2 Homo sapiens 129-132 15542158-10 2004 The efficacy of combined pentoxifylline-tocopherol treatment in superficial RIF was confirmed in a randomised clinical trial, and then in successful phase II trials especially in uterine fibroatrophy and osteoradionecrosis. Tocopherols 40-50 ras homolog family member F, filopodia associated Homo sapiens 76-79 15753133-4 2004 The renewed interest in the biological function of tocopherol binders is based on the discovery of ataxia with vitamin E deficiency, a neurological disorder that is caused by genetic defects of the alpha-TTP gene and/or vitamin E deficiency. Tocopherols 51-61 alpha tocopherol transfer protein Homo sapiens 198-207 15349118-2 2004 We hypothesized that fatty livers of obese rats have increased activation of signal transducers and activators of transcription-1 and transcription-3 (Stat-1 and Stat-3) and that tocopherol treatment will decrease Stat activation. Tocopherols 179-189 signal transducer and activator of transcription 1 Rattus norvegicus 151-157 15753158-2 2004 Both fluorescent tocopherol analogues bind specifically to recombinant human tocopherol transfer protein (hTTP). Tocopherols 17-27 ZFP36 ring finger protein Homo sapiens 106-110 15483005-2 2004 Our understanding of the fibrosis mechanisms and our clinical and experimental results for the treatment of radiation-induced fibrosis prompted us to postulate that EF might respond to treatment with combined pentoxifylline (PTX)-tocopherol (Vit.E). Tocopherols 230-240 vitrin Homo sapiens 242-245 15539527-3 2004 The results suggest that the physiological role of TAP in mast cells is not regulation of tocopherol function but an as-yet-unidentified activity. Tocopherols 90-100 SEC14-like lipid binding 4 Mus musculus 51-54 15349118-2 2004 We hypothesized that fatty livers of obese rats have increased activation of signal transducers and activators of transcription-1 and transcription-3 (Stat-1 and Stat-3) and that tocopherol treatment will decrease Stat activation. Tocopherols 179-189 signal transducer and activator of transcription 3 Rattus norvegicus 162-168 15349118-8 2004 Tocopherol administration decreased nuclear phosphoStat-3, increased cytoplasmic Stat-3, and decreased Stat-3 binding activity. Tocopherols 0-10 signal transducer and activator of transcription 3 Rattus norvegicus 51-57 15349118-8 2004 Tocopherol administration decreased nuclear phosphoStat-3, increased cytoplasmic Stat-3, and decreased Stat-3 binding activity. Tocopherols 0-10 signal transducer and activator of transcription 3 Rattus norvegicus 81-87 15349118-10 2004 Tocopherol treatment decreases Stat-3 activation and increases cytosolic Stat-3. Tocopherols 0-10 signal transducer and activator of transcription 3 Rattus norvegicus 31-37 15349118-10 2004 Tocopherol treatment decreases Stat-3 activation and increases cytosolic Stat-3. Tocopherols 0-10 signal transducer and activator of transcription 3 Rattus norvegicus 73-79 15349118-11 2004 Tocopherol-induced changes in Stat-3 may play a role in its beneficial effects in hepatic ischemia in fatty livers. Tocopherols 0-10 signal transducer and activator of transcription 3 Rattus norvegicus 30-36 15225597-9 2004 However, the tocopherols inhibited COX-2 activity showing that the tocopherols act post-transcriptionally on activity, whereas quercetin and some quercetin conjugates affect both the transcription and activity of COX-2. Tocopherols 13-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 35-40 15225597-9 2004 However, the tocopherols inhibited COX-2 activity showing that the tocopherols act post-transcriptionally on activity, whereas quercetin and some quercetin conjugates affect both the transcription and activity of COX-2. Tocopherols 67-78 prostaglandin-endoperoxide synthase 2 Homo sapiens 35-40 14737039-8 2004 Administration of antioxidants (vitamin C and a-tocopherol) caused attenuation of the endothelial damage, as vitamin C administration caused a significant decrease in sTM, vWF, fibrinogen and increased HDL-cholesterol, while a-tocopherol caused a significant decrease in vWF and sTM. Tocopherols 48-58 von Willebrand factor Rattus norvegicus 172-175 15247386-2 2004 Additional nonantioxidant functions of tocopherols have been proposed after the recent finding that the Suc export defective1 maize (Zea mays) mutant (sxd1) carries a defect in tocopherol cyclase (TC) and thus is devoid of tocopherols. Tocopherols 39-50 tocopherol cyclase, chloroplastic Zea mays 151-155 15247386-2 2004 Additional nonantioxidant functions of tocopherols have been proposed after the recent finding that the Suc export defective1 maize (Zea mays) mutant (sxd1) carries a defect in tocopherol cyclase (TC) and thus is devoid of tocopherols. Tocopherols 223-234 tocopherol cyclase, chloroplastic Zea mays 151-155 15247386-3 2004 However, the corresponding vitamin E deficient1 Arabidopsis mutant (vte1) lacks a phenotype analogous to sxd1, suggesting differences in tocopherol function between C4 and C3 plants. Tocopherols 137-147 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 68-72 15247386-6 2004 RNAi-mediated silencing of StSXD1 in transgenic potato plants resulted in the disruption of TC activity and severe tocopherol deficiency similar to the orthologous sxd1 and vte1 mutants. Tocopherols 115-125 tocopherol cyclase Solanum tuberosum 27-33 15630203-6 2004 When AsA and Tocopherol(Toc) were added to the medium from 0 to 20 microM, the TBARS values, with or without hydrogen peroxide, decreased significantly with increasing concentrations of AsA and Toc respectively (p < 0.05). Tocopherols 13-23 rhomboid 5 homolog 2 Homo sapiens 24-27 14657365-1 2003 Human alpha-tocopherol (alpha-T) transfer protein (ATTP) plays a central role in vitamin E homeostasis, preventing degradation of alpha-T by routing this lipophilic molecule for secretion by hepatocytes. Tocopherols 12-22 alpha tocopherol transfer protein Homo sapiens 51-55 15155886-3 2004 To address this issue, we have isolated and characterized two VITAMIN E loci (VTE1 and VTE2) in Arabidopsis that when mutated result in tocopherol deficiency in all tissues. Tocopherols 136-146 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 78-82 15155886-3 2004 To address this issue, we have isolated and characterized two VITAMIN E loci (VTE1 and VTE2) in Arabidopsis that when mutated result in tocopherol deficiency in all tissues. Tocopherols 136-146 homogentisate phytyltransferase 1 Arabidopsis thaliana 87-91 14871472-1 2004 It is known that gamma-tocopherol inhibits human prostate cancer cell proliferation via down-regulation of cyclin-related signalling but tocopherol and tocotrienol metabolites with a shortened phytyl chain, carboxyethyl hydroxychromans, were not previously investigated as anti-proliferative agents. Tocopherols 23-33 proliferating cell nuclear antigen Homo sapiens 107-113 14871472-8 2004 Tocopherols and carboxyethyl hydroxychromans exerted an inhibitory effect on cyclin D1 expression parallel to the retardation of cell growth. Tocopherols 0-11 cyclin D1 Homo sapiens 77-86 14726472-0 2004 Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Tocopherols 37-48 gamma-glutamyltransferase light chain family member 3 Homo sapiens 54-79 14970893-0 2004 [Effect of different isoforms of tocopherols on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells]. Tocopherols 33-44 intercellular adhesion molecule 1 Homo sapiens 62-95 14970893-1 2004 OBJECTIVE: To observe the influence of different tocopherol isoforms on oxidized low density lipoprotein (oxLDL) or recombinant human C-reactive protein (rhCRP)-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) and to investigate the potential mechanisms and effects of different tocopherols on atherosclerosis. Tocopherols 49-59 C-reactive protein Homo sapiens 134-152 14970893-1 2004 OBJECTIVE: To observe the influence of different tocopherol isoforms on oxidized low density lipoprotein (oxLDL) or recombinant human C-reactive protein (rhCRP)-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) and to investigate the potential mechanisms and effects of different tocopherols on atherosclerosis. Tocopherols 49-59 intercellular adhesion molecule 1 Homo sapiens 183-216 14970893-1 2004 OBJECTIVE: To observe the influence of different tocopherol isoforms on oxidized low density lipoprotein (oxLDL) or recombinant human C-reactive protein (rhCRP)-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) and to investigate the potential mechanisms and effects of different tocopherols on atherosclerosis. Tocopherols 346-357 intercellular adhesion molecule 1 Homo sapiens 183-216 14970893-5 2004 The different tocopherols inhibited oxLDL-induced ICAM-1 expression in HUVECs in a concentration-dependent manner (50-200 micromol/L) and mixed-tocopherols were more potent than alpha-tocopherol or gamma-tocopherol alone. Tocopherols 14-25 intercellular adhesion molecule 1 Homo sapiens 50-56 14970893-7 2004 CONCLUSION: The different tocopherols inhibited oxLDL-induced ICAM-1 expression in HUVECs and mixed-tocopherols were more potent than alpha-tocopherol or gamma-tocopherol alone, which may be important for the beneficial effects of tocopherols on atherosclerosis and cardiovascular disease. Tocopherols 26-37 intercellular adhesion molecule 1 Homo sapiens 62-68 14521714-0 2003 Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. Tocopherols 14-24 peroxisome proliferator activated receptor alpha Homo sapiens 81-85 14521714-22 2003 Upregulation of PPARgamma by the tocopherols and in particular by gamma-tocopherol may have relevance not only to cancer prevention but also to the management of inflammatory and cardiovascular disorders. Tocopherols 33-44 peroxisome proliferator activated receptor gamma Homo sapiens 16-25 14737039-8 2004 Administration of antioxidants (vitamin C and a-tocopherol) caused attenuation of the endothelial damage, as vitamin C administration caused a significant decrease in sTM, vWF, fibrinogen and increased HDL-cholesterol, while a-tocopherol caused a significant decrease in vWF and sTM. Tocopherols 48-58 von Willebrand factor Rattus norvegicus 271-274 14508009-5 2003 The ethyl methanesulfonate-derived vte3-1 allele alters tocopherol composition but has little impact on PQ levels, whereas the null vte3-2 allele is deficient in PQ and alpha- and gamma-tocopherols. Tocopherols 56-66 uncharacterized protein Chlamydomonas reinhardtii 35-39 14508009-9 2003 Intriguingly, the only prokaryotic genomes that contain VTE3-like sequences are those of two species of archea, suggesting that, in contrast to all other enzymes of the plant tocopherol pathway, the evolutionary origin of VTE3 may have been archeal rather than cyanobacterial. Tocopherols 175-185 uncharacterized protein Chlamydomonas reinhardtii 56-60 14508009-9 2003 Intriguingly, the only prokaryotic genomes that contain VTE3-like sequences are those of two species of archea, suggesting that, in contrast to all other enzymes of the plant tocopherol pathway, the evolutionary origin of VTE3 may have been archeal rather than cyanobacterial. Tocopherols 175-185 uncharacterized protein Chlamydomonas reinhardtii 222-226 14508009-10 2003 In vivo analyses of vte3 mutants and the corresponding homozygous Synechocystis sp PCC6803 sll0418::aphII mutant revealed important differences in enzyme redundancy, the regulation of tocopherol synthesis, and the integration of tocopherol and PQ biosynthesis in cyanobacteria and plants. Tocopherols 184-194 uncharacterized protein Chlamydomonas reinhardtii 20-24 14508009-10 2003 In vivo analyses of vte3 mutants and the corresponding homozygous Synechocystis sp PCC6803 sll0418::aphII mutant revealed important differences in enzyme redundancy, the regulation of tocopherol synthesis, and the integration of tocopherol and PQ biosynthesis in cyanobacteria and plants. Tocopherols 229-239 uncharacterized protein Chlamydomonas reinhardtii 20-24 14512521-0 2003 The role of homogentisate phytyltransferase and other tocopherol pathway enzymes in the regulation of tocopherol synthesis during abiotic stress. Tocopherols 102-112 homogentisate phytyltransferase 1 Arabidopsis thaliana 12-43 14512521-3 2003 Homogentisate phytyltransferase (HPT) is a key enzyme limiting tocopherol biosynthesis in unstressed Arabidopsis leaves (E. Collakova, D. DellaPenna [2003] Plant Physiol 131: 632-642). Tocopherols 63-73 homogentisate phytyltransferase 1 Arabidopsis thaliana 0-31 14512521-5 2003 Abiotic stress resulted in an 18- and 8-fold increase in total tocopherol content in wild-type and 35S::HPT1 leaves, respectively, with tocopherol levels in 35S::HPT1 being 2- to 4-fold higher than wild type at all experimental time points. Tocopherols 63-73 homogentisate phytyltransferase 1 Arabidopsis thaliana 104-108 14512521-5 2003 Abiotic stress resulted in an 18- and 8-fold increase in total tocopherol content in wild-type and 35S::HPT1 leaves, respectively, with tocopherol levels in 35S::HPT1 being 2- to 4-fold higher than wild type at all experimental time points. Tocopherols 136-146 homogentisate phytyltransferase 1 Arabidopsis thaliana 162-166 14512521-6 2003 Increased total tocopherol levels correlated with elevated HPT mRNA levels and HPT specific activity in 35S::HPT1 and wild-type leaves, suggesting that HPT activity limits total tocopherol synthesis during abiotic stress. Tocopherols 16-26 homogentisate phytyltransferase 1 Arabidopsis thaliana 109-113 12913173-6 2003 Mutations in the VTE1, SXD1, or slr1737 genes resulted in both tocopherol deficiency and the accumulation of 2,3-dimethyl-6-phytyl-1,4-benzoquinone (DMPBQ), a TC substrate. Tocopherols 63-73 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 17-21 12897790-4 2003 Transgenic expression of the barley HGGT in Arabidopsis thaliana leaves resulted in accumulation of tocotrienols, which were absent from leaves of nontransformed plants, and a 10- to 15-fold increase in total vitamin E antioxidants (tocotrienols plus tocopherols). Tocopherols 251-262 Homogentisate geranylgeranyltransferase Hordeum vulgare 36-40 12897790-5 2003 Overexpression of the barley HGGT in corn seeds resulted in an increase in tocotrienol and tocopherol content of as much as six-fold. Tocopherols 91-101 Homogentisate geranylgeranyltransferase Hordeum vulgare 29-33 12913173-6 2003 Mutations in the VTE1, SXD1, or slr1737 genes resulted in both tocopherol deficiency and the accumulation of 2,3-dimethyl-6-phytyl-1,4-benzoquinone (DMPBQ), a TC substrate. Tocopherols 63-73 tocopherol cyclase, chloroplastic Zea mays 23-27 12763054-1 2003 Tocopherols and tocotrienols are metabolized by side chain degradation initiated by cytochrome P450 (CYP)-catalyzed omega-hydroxylation followed by beta-oxidation. Tocopherols 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-99 14682617-6 2003 Over-expression of the gamma-TMT cDNA in vte4-1 restored wild-type tocopherol composition. Tocopherols 67-77 gamma-tocopherol methyltransferase Arabidopsis thaliana 23-32 12763054-3 2003 CYP3A4 and CYP4F2 were suggested to be involved in tocopherol degradation. Tocopherols 51-61 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 11-17 12763054-5 2003 Also tocopherols and in particular tocotrienols induce the expression of a PXR-driven reporter gene and the expression of endogenous CYP3A4 and CYP3A5 which is supported by sporadic publications spread over the last 30 years. Tocopherols 5-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 75-78 12763054-5 2003 Also tocopherols and in particular tocotrienols induce the expression of a PXR-driven reporter gene and the expression of endogenous CYP3A4 and CYP3A5 which is supported by sporadic publications spread over the last 30 years. Tocopherols 5-16 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 133-139 12763054-5 2003 Also tocopherols and in particular tocotrienols induce the expression of a PXR-driven reporter gene and the expression of endogenous CYP3A4 and CYP3A5 which is supported by sporadic publications spread over the last 30 years. Tocopherols 5-16 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 144-150 12763054-1 2003 Tocopherols and tocotrienols are metabolized by side chain degradation initiated by cytochrome P450 (CYP)-catalyzed omega-hydroxylation followed by beta-oxidation. Tocopherols 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-104 12763054-3 2003 CYP3A4 and CYP4F2 were suggested to be involved in tocopherol degradation. Tocopherols 51-61 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 12586887-0 2003 Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Tocopherols 57-67 homogentisate phytyltransferase 1 Arabidopsis thaliana 0-31 12566075-2 2003 Phospholipid hydroperoxide glutathione peroxidase (GPX4) is the only major antioxidant enzyme known to directly reduce phospholipid hydroperoxides within membranes and lipoproteins, acting in conjunction with alpha tocopherol (vitamin E) to inhibit lipid peroxidation. Tocopherols 215-225 glutathione peroxidase 4 Mus musculus 51-55 12568863-1 2003 OBJECTIVE: To determine whether treatment with combined pentoxifylline (PTX) and tocopherol (Vit.E) can improve uterine parameters in hormonal replacement therapy (HRT)-resistant women with premature ovarian failure (POF), for whom the outcome of assisted reproductive technology is usually negative. Tocopherols 81-91 vitrin Homo sapiens 93-96 12746535-0 2003 Chloroplast membrane photostability in chlP transgenic tobacco plants deficient in tocopherols. Tocopherols 83-94 geranylgeranyl diphosphate reductase, chloroplastic Nicotiana tabacum 39-43 12600864-8 2003 NO release, ecNOS activation, and SOD protein content in platelets increased in the tocopherol-treated groups. Tocopherols 84-94 nitric oxide synthase 3 Homo sapiens 12-17 12600864-8 2003 NO release, ecNOS activation, and SOD protein content in platelets increased in the tocopherol-treated groups. Tocopherols 84-94 superoxide dismutase 1 Homo sapiens 34-37 12600864-10 2003 Mixed tocopherols were more potent than alpha-tocopherol alone in modulating NO release and ecNOS activation but not SOD protein content or PKC activation. Tocopherols 6-17 nitric oxide synthase 3 Homo sapiens 92-97 12600864-12 2003 Effects of mixed tocopherols were associated with increased NO release, ecNOS activation, and SOD protein content in platelets, which may contribute to the effect on platelet aggregation. Tocopherols 17-28 nitric oxide synthase 3 Homo sapiens 72-77 12600864-12 2003 Effects of mixed tocopherols were associated with increased NO release, ecNOS activation, and SOD protein content in platelets, which may contribute to the effect on platelet aggregation. Tocopherols 17-28 superoxide dismutase 1 Homo sapiens 94-97 12586887-4 2003 To investigate whether HPT activity is limiting for tocopherol synthesis in plants, the gene encoding Arabidopsis HPT, HPT1, was constitutively overexpressed in Arabidopsis. Tocopherols 52-62 homogentisate phytyltransferase 1 Arabidopsis thaliana 119-123 12586887-5 2003 In leaves, HPT1 overexpression resulted in a 10-fold increase in HPT specific activity and a 4.4-fold increase in total tocopherol content relative to wild type. Tocopherols 120-130 homogentisate phytyltransferase 1 Arabidopsis thaliana 11-15 12586887-6 2003 In seeds, HPT1 overexpression resulted in a 4-fold increase in HPT specific activity and a total seed tocopherol content that was 40% higher than wild type, primarily because of an increase in gamma-tocopherol content. Tocopherols 102-112 homogentisate phytyltransferase 1 Arabidopsis thaliana 10-14 12586887-9 2003 These results indicate that HPT activity is limiting in various Arabidopsis tissues and that total tocopherol levels and vitamin E activity can be elevated in leaves and seeds by combined overexpression of the HPT1 and gamma-tocopherol methyltransferase genes. Tocopherols 99-109 homogentisate phytyltransferase 1 Arabidopsis thaliana 210-214 14506001-7 2003 Palm vitamin E (30% tocopherols, 70% tocotrienols) has been extensively researched for its nutritional and health properties, including antioxidant activities, cholesterol lowering, anti-cancer effects and protection against atherosclerosis. Tocopherols 20-31 paralemmin Homo sapiens 0-4 14506001-1 2003 The palm fruit (Elaies guineensis) yields palm oil, a palmitic-oleic rich semi solid fat and the fat-soluble minor components, vitamin E (tocopherols, tocotrienols), carotenoids and phytosterols. Tocopherols 138-149 paralemmin Homo sapiens 4-8 12452636-4 2002 C3G elevated the concentrations of tocopherols in the liver and lungs (P < 0.05). Tocopherols 35-46 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 0-3 12739983-12 2003 The hepatic alpha-tocopherol transfer protein (alpha-TTP) together with the tocopherol-associated proteins (TAP) are responsbile for the endogenous accumulation of natural alpha-tocopherol. Tocopherols 18-28 alpha tocopherol transfer protein Homo sapiens 47-56 12739983-13 2003 Elimination of alpha-tocopherol takes several days with a t((1/2)) of 81 and 73 hours for R,R,R-alpha-tocopherol and all-rac-alpha-tocopherol, respectively. Tocopherols 21-31 AKT serine/threonine kinase 1 Homo sapiens 121-130 12475907-7 2003 A potent antioxidant, a-tocopherol, prevented cognition impairment and lipid peroxide accumulation and decreased the number of apoptotic cells in klotho mutant mice. Tocopherols 24-34 klotho Mus musculus 146-152 12430028-1 2002 Coronatine-inducible tyrosine aminotransferase (TAT), which catalyses the transamination from tyrosine to p-hydroxyphenylpyruvate, is the first enzyme of a pathway leading via homogentisic acid to plastoquinone and tocopherols, the latter of which are known to be radical scavengers in plants. Tocopherols 215-226 tyrosine aminotransferase 3 Arabidopsis thaliana 21-46 12607825-5 2002 Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Tocopherols 24-34 C-reactive protein Homo sapiens 185-203 12607825-5 2002 Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Tocopherols 24-34 serpin family E member 1 Homo sapiens 236-241 12430028-1 2002 Coronatine-inducible tyrosine aminotransferase (TAT), which catalyses the transamination from tyrosine to p-hydroxyphenylpyruvate, is the first enzyme of a pathway leading via homogentisic acid to plastoquinone and tocopherols, the latter of which are known to be radical scavengers in plants. Tocopherols 215-226 tyrosine aminotransferase 3 Arabidopsis thaliana 48-51 11997390-0 2002 Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Tocopherols 45-55 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 11997390-3 2002 Here we describe a pathway involving cytochrome P450-mediated omega-hydroxylation of the tocopherol phytyl side chain followed by stepwise removal of two- or three-carbon moieties, ultimately yielding the 3"-carboxychromanol metabolite that is excreted in urine. Tocopherols 89-99 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 48-52 11997390-8 2002 Sesamin potently inhibited tocopherol-omega-hydroxylase activity exhibited by CYP4F2 and rat or human liver microsomes. Tocopherols 27-37 cytochrome P450, family 4, subfamily f, polypeptide 1 Rattus norvegicus 78-84 12065410-5 2002 We demonstrate that the conversion of a specific glutamate residue (E306) to an alanine in this region locks TREK-1 in the open configuration and abolishes the cAMP/PKA down-modulation. Tocopherols 68-72 potassium two pore domain channel subfamily K member 2 Homo sapiens 109-115 12213958-2 2002 A tocopherol-deficient mutant (vte1) was isolated from Arabidopsis thaliana by using a TLC-based screening approach. Tocopherols 2-12 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 31-35 12213958-10 2002 During photo-oxidative stress, chlorophyll content and photosynthetic quantum yield were slightly reduced in vte1 as compared with wild type indicating a potential role for tocopherol in maintaining an optimal photosynthesis rate under high-light stress. Tocopherols 173-183 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 109-113 12011362-15 2002 In addition, evidence that antisense expression of HPT1 in Arabidopsis resulted in reduced seed tocopherol levels, whereas seed-specific sense expression resulted in increased seed tocopherol levels, is presented. Tocopherols 96-106 homogentisate phytyltransferase 1 Arabidopsis thaliana 51-55 12011362-15 2002 In addition, evidence that antisense expression of HPT1 in Arabidopsis resulted in reduced seed tocopherol levels, whereas seed-specific sense expression resulted in increased seed tocopherol levels, is presented. Tocopherols 181-191 homogentisate phytyltransferase 1 Arabidopsis thaliana 51-55 12440523-3 2002 Previously, we found that tocopherols and diverse tocopherol derivatives can inhibit the activity of human glutathione S-transferase P1-1 (GST P1-1). Tocopherols 26-37 glutathione S-transferase pi 1 Homo sapiens 139-147 12440523-3 2002 Previously, we found that tocopherols and diverse tocopherol derivatives can inhibit the activity of human glutathione S-transferase P1-1 (GST P1-1). Tocopherols 26-36 glutathione S-transferase pi 1 Homo sapiens 139-147 12440523-7 2002 We also examined the 3D structure of GST P1-1 for a possible tocopherol/tocotrienol binding site. Tocopherols 61-71 glutathione S-transferase pi 1 Homo sapiens 37-45 12027671-10 2002 The transformation of p-quinone 2 into acetophenone 3 might contribute to the chemistry of tocopherols oxidized at C-4, i.e., 4-hydroxy-alpha-tocopherol and 4-oxo-alpha-tocopherol, which have been proposed as precursors of natural vitamin E metabolites. Tocopherols 91-102 complement C4A (Rodgers blood group) Homo sapiens 115-118 12036843-2 2002 In a preliminary study, a combination of pentoxifylline (PTX), tocopherol (Vit-E) and clodonate has been shown to be of clinical benefit with more than 50% regression of progressive ORN observed at 6 months in 12 patients. Tocopherols 63-73 vitrin Homo sapiens 75-78 12065410-7 2002 We conclude that protonation of E306 tunes the TREK-1 mechanical setpoint and thus sets lipid sensitivity. Tocopherols 32-36 potassium two pore domain channel subfamily K member 2 Homo sapiens 47-53 11846411-7 2002 Both tocopherol preparations attenuated cell injury and markedly decreased the effects of H-R on SOD activity and iNOS expression/activity (all P < 0.05 vs H-R group, n = 5). Tocopherols 5-15 nitric oxide synthase 2 Rattus norvegicus 114-118 11736999-4 2001 Studies were conducted to determine if the antiproliferative effects of specific tocopherol and tocotrienol isoforms are associated with a reduction in EGF-receptor mitogenic signalling and/or PKC activation. Tocopherols 81-91 protein kinase C, alpha Mus musculus 193-196 11736999-9 2001 These findings demonstrate that the inhibitory effects of specific tocopherol and tocotrienol isoforms on EGF-dependent normal mammary epithelial cell mitogenesis occurs downstream from the EGF-receptor and appears to be mediated, at least in part, by a reduction in PKC(alpha) activation. Tocopherols 67-77 protein kinase C, alpha Mus musculus 267-276 11556795-1 2001 The enzyme geranylgeranyl reductase (CHL P) catalyses the reduction of geranylgeranyl diphosphate to phytyl diphosphate in higher-plant chloroplasts and provides phytol for both chlorophyll (Chl) and tocopherol synthesis. Tocopherols 200-210 geranylgeranyl diphosphate reductase, chloroplastic Nicotiana tabacum 37-42 12199080-1 2001 While estimating the effect of tocopherol, tocopherylquinone and their complexes with the tocopherol-binding proteins from the rat liver cytosole on arachidonate 5-lipoxygenase from peritoneal-lymphocytes and soybean linoleate-5-lipoxygenase alpha-tocopherol and especially its complex with tocopherol-binding protein was defined to inhibit the activity of both vegetative- and animal nature-lipoxygenase. Tocopherols 90-100 arachidonate 5-lipoxygenase Rattus norvegicus 149-176 12199080-1 2001 While estimating the effect of tocopherol, tocopherylquinone and their complexes with the tocopherol-binding proteins from the rat liver cytosole on arachidonate 5-lipoxygenase from peritoneal-lymphocytes and soybean linoleate-5-lipoxygenase alpha-tocopherol and especially its complex with tocopherol-binding protein was defined to inhibit the activity of both vegetative- and animal nature-lipoxygenase. Tocopherols 90-100 arachidonate 5-lipoxygenase Rattus norvegicus 149-176 11556795-2 2001 The reduction in CHL P activity in transgenic tobacco (Nicotiana tabacum L.) plants is accompanied by the reduction in total Chl and tocopherol content and the accumulation of geranylgeranylated Chl (ChlGG). Tocopherols 133-143 geranylgeranyl diphosphate reductase, chloroplastic Nicotiana tabacum 17-22 11440834-9 2001 It is discussed that competition of microsomal omega-oxidation with specific binding by the alpha-tocopherol transfer protein (alpha-TTP) determines the metabolic fate of the individual tocopherols. Tocopherols 186-197 alpha tocopherol transfer protein Homo sapiens 92-125 11431728-8 2001 Pretreatment with TOC and ascorbate over 48 hours completely corrected the decreases in GSH, TOC, and CAT. Tocopherols 18-21 catalase Rattus norvegicus 102-105 11509922-7 2001 These isoforms of tocopherol did not affect cNOS protein expression, but enhanced cNOS phosphorylation in platelets. Tocopherols 18-28 nitric oxide synthase 3 Homo sapiens 82-86 11444841-6 2001 Ligand competition analysis showed that recombinant TAP binds to alpha-tocopherol but not to other isomers of tocopherols. Tocopherols 110-121 SEC14 like lipid binding 2 Homo sapiens 52-55 11451434-10 2001 Therefore we have studied the effect of various tocopherol derivatives on GST P1-1 activity. Tocopherols 48-58 glutathione S-transferase pi 1 Homo sapiens 74-82 11451434-16 2001 The potential implications of GST P1-1 inhibition by tocopherol and alpha-tocopherol derivatives are discussed. Tocopherols 53-63 glutathione S-transferase pi 1 Homo sapiens 30-38 11699868-2 2001 A possibility is discussed that tocopherol provides for the activity of the lipid-radical cycles involving cytochrome b5. Tocopherols 32-42 cytochrome b5 type A Homo sapiens 107-120 11519885-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 55-66 lipoprotein lipase Homo sapiens 17-35 11519885-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 55-66 lipoprotein lipase Homo sapiens 37-40 11519885-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 186-197 lipoprotein lipase Homo sapiens 17-35 11519885-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 186-197 lipoprotein lipase Homo sapiens 37-40 11440834-9 2001 It is discussed that competition of microsomal omega-oxidation with specific binding by the alpha-tocopherol transfer protein (alpha-TTP) determines the metabolic fate of the individual tocopherols. Tocopherols 186-197 alpha tocopherol transfer protein Homo sapiens 127-136 11061988-2 2000 We employed well-characterized inhibitors of specific cytochrome P-450 (CYP) enzymes to determine which form was likely involved in tocopherol side chain oxidation. Tocopherols 132-142 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-70 11579997-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 55-66 lipoprotein lipase Homo sapiens 17-35 11579997-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 55-66 lipoprotein lipase Homo sapiens 37-40 11579997-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 186-197 lipoprotein lipase Homo sapiens 17-35 11579997-8 2001 By the action of lipoprotein lipase (LPL), part of the tocopherols transported in chylomicrons are taken up by extrahepatic tissues, and the remnant chylomicrons transport the remaining tocopherols to the liver. Tocopherols 186-197 lipoprotein lipase Homo sapiens 37-40 11061988-2 2000 We employed well-characterized inhibitors of specific cytochrome P-450 (CYP) enzymes to determine which form was likely involved in tocopherol side chain oxidation. Tocopherols 132-142 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-75 11061988-6 2000 These results support a CYP3A-dependent mechanism of side chain metabolism of tocopherols to water-soluble carboxychromans, and provide the first evidence of a specific enzyme involved in vitamin E metabolism. Tocopherols 78-89 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 24-29 10737223-1 1999 The effects of ascorbic acid (AsA) on membrane phospholipids (PLs) and tocopherols (Tocs) of human erythrocyte during peroxidation by soybean lipoxygenase (LOX) were investigated. Tocopherols 71-82 linoleate 9S-lipoxygenase-4 Glycine max 142-154 10964265-6 2000 Results also showed that CL-S1, -SA, and +SA cells preferentially accumulate tocotrienols as compared with tocopherols, and this may partially explain why tocotrienols display greater biopotency than tocopherols. Tocopherols 200-211 CD52 antigen Mus musculus 25-30 10757547-2 2000 Discrimination between different forms of tocopherol is thought to take place via the hepatic alpha-tocopherol transfer protein (alpha-TTP). Tocopherols 42-52 alpha tocopherol transfer protein Rattus norvegicus 94-127 10757547-2 2000 Discrimination between different forms of tocopherol is thought to take place via the hepatic alpha-tocopherol transfer protein (alpha-TTP). Tocopherols 42-52 alpha tocopherol transfer protein Rattus norvegicus 129-138 10966898-0 2000 Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Tocopherols 104-115 insulin Homo sapiens 17-24 10829015-10 2000 TAP binds to alpha-tocopherol and biotinylated tocopherol, suggesting the existence of a hydrophobic pocket, possibly analogous to that of SEC14. Tocopherols 19-29 SEC14 like lipid binding 2 Homo sapiens 0-3 10751558-9 2000 Moreover, our results demonstrate that tocopherols may exert their antiatherogenic effects at least in part via reduction of the MAPK and JunK cascade together with a protective profile of apoptotic genes of the Bcl-2 family. Tocopherols 39-50 BCL2 apoptosis regulator Homo sapiens 212-217 10540874-2 1999 alpha-Tocopherol transfer protein (alpha-TTP) is a liver cytosolic protein, which specifically binds alpha-tocopherol, and plays an important role in the discrimination of various tocopherols in the body. Tocopherols 180-191 alpha tocopherol transfer protein Homo sapiens 0-33 10515579-8 1999 Generation of ROIs, activation of NF-kappaB, and induction of apoptosis were not only prevented by antioxidants (thioctic acid, tocopherol, superoxide dysmutase-mimetic), but also by L-nitroarginine. Tocopherols 128-138 nuclear factor kappa B subunit 1 Homo sapiens 34-43 10540874-2 1999 alpha-Tocopherol transfer protein (alpha-TTP) is a liver cytosolic protein, which specifically binds alpha-tocopherol, and plays an important role in the discrimination of various tocopherols in the body. Tocopherols 180-191 alpha tocopherol transfer protein Homo sapiens 35-44 10398704-5 1999 Our results indicate that CHL P provides phytol for both tocopherol and Chl synthesis. Tocopherols 58-68 geranylgeranyl diphosphate reductase, chloroplastic Nicotiana tabacum 27-32 10506631-2 1999 RIF treatment with combined pentoxifylline (PTX) and tocopherol (Vit E) was prompted by recent advances in cellular and molecular biology that have improved researchers" understanding of radiation-induced late-injury mechanisms and by the excellent results from our previous human and animal studies. Tocopherols 53-63 vitrin Homo sapiens 65-68 10232825-4 1999 TS-tris was the only tocopherol which significantly decreased CYP2E1 activity after 18 h. This decrease in CYP2E1 activity is likely to limit the activation of CCl4 and protect against CCl4-induced hepatotoxicity. Tocopherols 21-31 C-C motif chemokine ligand 4 Rattus norvegicus 160-164 10232825-1 1999 A series of tocopherol compounds were examined for their capacity to protect against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Tocopherols 12-22 C-C motif chemokine ligand 4 Rattus norvegicus 107-111 10232825-4 1999 TS-tris was the only tocopherol which significantly decreased CYP2E1 activity after 18 h. This decrease in CYP2E1 activity is likely to limit the activation of CCl4 and protect against CCl4-induced hepatotoxicity. Tocopherols 21-31 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 62-68 10232825-4 1999 TS-tris was the only tocopherol which significantly decreased CYP2E1 activity after 18 h. This decrease in CYP2E1 activity is likely to limit the activation of CCl4 and protect against CCl4-induced hepatotoxicity. Tocopherols 21-31 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 107-113 10098661-1 1999 Sethoxydim, a commercially available cyclohexanedione class herbicide by targeting the enzymatic activity of acetyl-coenzyme A carboxylase, has been found to moderately inhibit the activity of 4-hydroxyphenylpyruvate dioxygenase, a key enzyme in the biosynthesis of plastoquinones and tocopherols in plants. Tocopherols 285-296 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 193-228 10497178-5 1999 However, bicarbonate enhanced SOD1/H(2)O(2)-dependent oxidation of tocopherols in the presence and absence of nitrite and dramatically enhanced SOD1/H(2)O(2)-mediated oxidation of unsaturated lipid in the presence of nitrite. Tocopherols 67-78 superoxide dismutase 1 Homo sapiens 30-34 10232825-4 1999 TS-tris was the only tocopherol which significantly decreased CYP2E1 activity after 18 h. This decrease in CYP2E1 activity is likely to limit the activation of CCl4 and protect against CCl4-induced hepatotoxicity. Tocopherols 21-31 C-C motif chemokine ligand 4 Rattus norvegicus 185-189 9507996-11 1998 induced peroxidation of plasma lipoproteins in atherogenesis-susceptible apoE-/- mice exhibits some, though not all, features of tocopherol-mediated peroxidation (TMP). Tocopherols 129-139 apolipoprotein E Mus musculus 73-77 9920007-7 1998 Tocopherols (alpha-Toch + beta-Toch) produced a proportional correlation on both PKC stimulation and endothelin secretion by inhibiting the effect of thrombin. Tocopherols 0-11 coagulation factor II, thrombin Bos taurus 150-158 9585479-14 1998 These results indicate an important role for tocopherol-mediated peroxidation and co-antioxidation in peroxynitrite-induced lipoprotein lipid peroxidation, especially when peroxynitrite is formed time-dependently by SIN-1. Tocopherols 45-55 MAPK associated protein 1 Homo sapiens 216-221 9569615-0 1998 Dissimilar protection of tocopherol isomers against membrane hydrolysis by phospholipase A2. Tocopherols 25-35 phospholipase A2 group IB Homo sapiens 75-91 9569615-5 1998 Other tocopherols, such as the isomers beta-, gamma- and delta-tocopherol also display PLA2 inhibition but consecutively to a lower extent. Tocopherols 6-17 phospholipase A2 group IB Homo sapiens 87-91 9569615-6 1998 The grade of inhibition of PLA2 activity by tocopherols correlates well with their biological activity and with their location in the bilayer as shown by fluorescence quenching. Tocopherols 44-55 phospholipase A2 group IB Homo sapiens 27-31 9569615-8 1998 The possible mechanisms underlying the different behaviour of tocopherol isomers as PLA2 inhibitors are discussed considering its biological significance as membrane stabilizers, suggesting biological actions of compounds with vitamin E activity other than their classical roles as antioxidants. Tocopherols 62-72 phospholipase A2 group IB Homo sapiens 84-88 11938728-5 1999 The tocopherols were eluted with methanol mobile phase at a flow rate of 1.0 ml.min-1 and detected by fluorescence(lambda exc = 295 nm, lambda em = 330 nm). Tocopherols 4-15 CD59 molecule (CD59 blood group) Homo sapiens 80-85 9701587-3 1998 Mutation of the PDS1 locus disrupts the activity of p-hydroxyphenylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone and tocopherols in plants. Tocopherols 167-178 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 16-20 9701587-3 1998 Mutation of the PDS1 locus disrupts the activity of p-hydroxyphenylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone and tocopherols in plants. Tocopherols 167-178 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 52-87 9701587-3 1998 Mutation of the PDS1 locus disrupts the activity of p-hydroxyphenylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone and tocopherols in plants. Tocopherols 167-178 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 89-96 9473813-1 1997 Developmental changes in expression of alpha-TTP after birth were investigated using rats with respect to plasma changes of tocopherols. Tocopherols 124-135 alpha tocopherol transfer protein Rattus norvegicus 39-48 9531500-1 1998 alpha-Tocopherol transfer protein (alpha-TTP) supplements nascent very-low-density lipoprotein (VLDL) preferentially with alpha-tocopherol by selecting the alpha-isomers against other stereoisomers of tocopherol. Tocopherols 128-138 alpha tocopherol transfer protein Rattus norvegicus 0-33 9531500-1 1998 alpha-Tocopherol transfer protein (alpha-TTP) supplements nascent very-low-density lipoprotein (VLDL) preferentially with alpha-tocopherol by selecting the alpha-isomers against other stereoisomers of tocopherol. Tocopherols 128-138 alpha tocopherol transfer protein Rattus norvegicus 35-44 9531500-3 1998 We investigated whether the expression of the hepatic alpha-TTP can be induced by dietary tocopherols. Tocopherols 90-101 alpha tocopherol transfer protein Rattus norvegicus 54-63 9531500-10 1998 The data show that both tocopherol isomers were able to induce alpha-TTP mRNA in rat liver and, thus, the ability of liver to select for the alpha-isomer. Tocopherols 24-34 alpha tocopherol transfer protein Rattus norvegicus 63-72 9523032-2 1998 Recently, this discrimination of tocopherol is considered to be attributed to alpha-tocopherol transfer protein (alpha-TTP) which binds to alpha-toc in preference to the other forms of tocopherol in the liver. Tocopherols 33-43 alpha tocopherol transfer protein Rattus norvegicus 78-111 9523032-2 1998 Recently, this discrimination of tocopherol is considered to be attributed to alpha-tocopherol transfer protein (alpha-TTP) which binds to alpha-toc in preference to the other forms of tocopherol in the liver. Tocopherols 33-43 alpha tocopherol transfer protein Rattus norvegicus 113-122 9523032-2 1998 Recently, this discrimination of tocopherol is considered to be attributed to alpha-tocopherol transfer protein (alpha-TTP) which binds to alpha-toc in preference to the other forms of tocopherol in the liver. Tocopherols 84-94 alpha tocopherol transfer protein Rattus norvegicus 113-122 9523032-3 1998 In the present study, developmental changes in expression of alpha-TTP after birth were investigated using rats with respect to plasma changes of tocopherols. Tocopherols 146-157 alpha tocopherol transfer protein Rattus norvegicus 61-70 8708817-1 1996 Developmental changes in expression of alpha-tocopherol transfer protein (alpha-TTP) after birth were investigated using rats with respect to plasma changes of tocopherols. Tocopherols 160-171 alpha tocopherol transfer protein Rattus norvegicus 39-72 9350472-3 1997 The antioxidative vitamins, ascorbic acid and the tocopherols, are important not only for limiting tissue damage but also in preventing increased cytokine production which is a consequence of excessive activation of NF kappa B. Tocopherols 50-61 nuclear factor kappa B subunit 1 Homo sapiens 216-226 8624378-12 1996 This pilot study demonstrates that treatment with ATRA/G-CSF/EPO/tocopherol is well tolerated, leading to normalization of neutrophil counts in most, and to improvement of platelets and red blood cells in a significant subgroup of patients. Tocopherols 65-75 erythropoietin Homo sapiens 61-64 9084498-5 1997 The experiments using some scavengers of active oxygen species revealed that tocopherol and ascorbic acid could strongly reduced LA oxidation caused by Cyt c or Mb. Tocopherols 77-87 cytochrome c, somatic Homo sapiens 152-157 8698868-8 1996 After alpha tocopherol supplementation, there were significant decreases in release of reactive oxygen species, lipid oxidation, IL-1 beta secretion, and monocyte-endothelial cell adhesion, both in resting and activated cells compared with baseline and washout phases. Tocopherols 12-22 interleukin 1 beta Homo sapiens 129-138 8624378-12 1996 This pilot study demonstrates that treatment with ATRA/G-CSF/EPO/tocopherol is well tolerated, leading to normalization of neutrophil counts in most, and to improvement of platelets and red blood cells in a significant subgroup of patients. Tocopherols 65-75 colony stimulating factor 3 Homo sapiens 55-60 8708817-1 1996 Developmental changes in expression of alpha-tocopherol transfer protein (alpha-TTP) after birth were investigated using rats with respect to plasma changes of tocopherols. Tocopherols 160-171 alpha tocopherol transfer protein Rattus norvegicus 74-83 9117192-4 1996 Quenching of ROS is affected by the redox buffer, glutathione (GSH), and the antioxidants, ascorbic acid, tocopherols, retinoids, in conjunction with the redox enzymes, GSH reductase, GSH peroxidase, catalase and superoxide dismutase. Tocopherols 106-117 catalase Homo sapiens 200-208 8718624-6 1995 Analysis of pds1 and pds2 shows that both mutants are plastoquinone and tocopherol deficient, in addition to their inability to desaturate phytoene. Tocopherols 72-82 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 12-16 8718624-6 1995 Analysis of pds1 and pds2 shows that both mutants are plastoquinone and tocopherol deficient, in addition to their inability to desaturate phytoene. Tocopherols 72-82 homogentisate prenyltransferase Arabidopsis thaliana 21-25 8186246-0 1994 Inhibition of cholinesterase activity by tetrahydroaminoacridine and the hemisuccinate esters of tocopherol and cholesterol. Tocopherols 97-107 butyrylcholinesterase Homo sapiens 14-28 8691781-3 1995 Combination of tocopherol with nicotinamide as adjuvants to conventional insulin therapy promoted normalization of lipid peroxidation and AED, improving beta-cell function. Tocopherols 15-25 insulin Homo sapiens 73-80 8109730-4 1993 The tocopherol compounds are separated on a C-18 column using a mobile phase containing 12% acetonitrile, 83% methanol, and 5% buffer (NaH2PO4.H2O, 7.5 mM final concentration) and are detected electrochemically. Tocopherols 4-14 Bardet-Biedl syndrome 9 Homo sapiens 44-48 7903615-4 1993 Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. Tocopherols 16-26 gamma-glutamyltransferase 1 Rattus norvegicus 51-54 8251749-10 1993 The purified human TBP exhibited displaceable, specific alpha-tocopherol binding in the gel filtration assay of tocopherol binding. Tocopherols 62-72 TATA-box binding protein Homo sapiens 19-22 7903615-0 1993 Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. Tocopherols 128-138 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 7903615-6 1993 Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. Tocopherols 16-26 hematopoietic prostaglandin D synthase Rattus norvegicus 61-64 7903615-0 1993 Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. Tocopherols 128-138 gamma-glutamyltransferase 1 Rattus norvegicus 30-59 7903615-2 1993 The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. Tocopherols 30-40 hematopoietic prostaglandin D synthase Rattus norvegicus 44-69 7903615-2 1993 The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. Tocopherols 30-40 gamma-glutamyltransferase 1 Rattus norvegicus 80-109 7903615-6 1993 Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. Tocopherols 16-26 hematopoietic prostaglandin D synthase Rattus norvegicus 141-144 8291130-3 1993 It is established that the both complexes are the inhibitors of phospholipase A2, under these conditions tocopherylquinone complex with proteins-acceptors more intensively decreases Km of the enzyme than the complex tocopherol-proteins-acceptors. Tocopherols 216-226 phospholipase A2 group IB Rattus norvegicus 64-80 21043857-7 1993 Concentrations of tocopherol between 0.075 mM and 0.0075 mM had inhibiting influences on activation of washed platelets by thrombin. Tocopherols 18-28 coagulation factor II, thrombin Homo sapiens 123-131 1872919-0 1991 Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol. Tocopherols 66-76 interleukin 1 beta Homo sapiens 14-23 1354687-9 1992 Tocopherol also significantly inhibited fibrinogen-induced aggregation of elastase-treated platelets at a concentration of 0.1 mM. Tocopherols 0-10 fibrinogen beta chain Homo sapiens 40-50 1354687-11 1992 The inhibitory effect of the platelet aggregation of tocopherol may be partially accomplished through interference with fibrinogen binding towards its receptor. Tocopherols 53-63 fibrinogen beta chain Homo sapiens 120-130 1655032-8 1991 (6) Low molecular weight thiols and tocopherol protect the microsomal glucose-6-phosphatase against MTAS-induced inhibition. Tocopherols 36-46 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 70-91 1872919-2 1991 The possible action of probucol and tocopherol on the expression and secretion of IL-1 beta was investigated using the human monocytic leukemia cell line, THP-1. Tocopherols 36-46 interleukin 1 beta Homo sapiens 82-91 1872919-4 1991 Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene. Tocopherols 61-71 interleukin 1 beta Homo sapiens 12-21 1872919-4 1991 Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene. Tocopherols 61-71 interleukin 1 beta Homo sapiens 136-145 1985900-5 1991 A good correlation between the rate constants and the mole fraction of ascorbate monoanion (AsH-) was observed, showing that ascorbate (AsH-) can regenerate the tocopherol from tocopheroxyl in biological systems. Tocopherols 161-171 arylsulfatase family member H Homo sapiens 92-95 1985900-5 1991 A good correlation between the rate constants and the mole fraction of ascorbate monoanion (AsH-) was observed, showing that ascorbate (AsH-) can regenerate the tocopherol from tocopheroxyl in biological systems. Tocopherols 161-171 arylsulfatase family member H Homo sapiens 136-139 1985900-7 1991 On the other hand, it was found that AsH2 can reduce the tocopheroxyl to tocopherol in benzene/ethanol (2:1) mixtures, although the rate of reaction is only approximately 15% of that observed in micellar solution at pH 7. Tocopherols 73-83 ASH2 like, histone lysine methyltransferase complex subunit Homo sapiens 37-41 1794697-4 1991 Violuric acid, as compared with unithiol, ascorbic acid and tocopherol, was more effective in decreasing methemoglobin and nitrates contents in blood in methemoglobinemia cases. Tocopherols 60-70 hemoglobin subunit gamma 2 Homo sapiens 105-118 2107879-6 1990 Analysis of these enzymes revealed that phospholipase A2 activity was enhanced by tocopherol enrichment, whereas lysophospholipase and acyl-CoA acyltransferase were unaffected. Tocopherols 82-92 phospholipase A2 group IB Homo sapiens 40-56 34785321-3 2022 Research has established that tocopherols and tocotrienols are metabolized via omega-hydroxylase (CYP4F2)-initiated side chain oxidation to form 13"-hydroxychromanol and 13"-carobyxychromanol (13"-COOH). Tocopherols 30-41 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 98-104 2262013-0 1990 "Threshold effect" of increasing tocopherol ingestion upon the microsomal epoxide hydrolase activity of rat liver. Tocopherols 33-43 epoxide hydrolase 1 Rattus norvegicus 63-91 35079241-8 2022 Furthermore, thiamine, biotin, and tocopherol are viewed as satisfying inhibitors to Mpro, but pyridoxine was observed as the weakest inhibitor. Tocopherols 35-45 NEWENTRY Severe acute respiratory syndrome-related coronavirus 85-89 34496685-7 2021 Furthermore, the 0.01% TCP mixture group also showed higher tear film lipid layer grades and conjunctival goblet cell density and lower corneal fluorescein staining scores, number of CD4 + IFN-gamma+ T cells, and levels of TNF-alpha, IL-1beta, and CCL4 than the DQS alone group (P < 0.05). Tocopherols 23-26 CD4 antigen Mus musculus 183-186 34496685-7 2021 Furthermore, the 0.01% TCP mixture group also showed higher tear film lipid layer grades and conjunctival goblet cell density and lower corneal fluorescein staining scores, number of CD4 + IFN-gamma+ T cells, and levels of TNF-alpha, IL-1beta, and CCL4 than the DQS alone group (P < 0.05). Tocopherols 23-26 interferon gamma Mus musculus 189-198 34496685-7 2021 Furthermore, the 0.01% TCP mixture group also showed higher tear film lipid layer grades and conjunctival goblet cell density and lower corneal fluorescein staining scores, number of CD4 + IFN-gamma+ T cells, and levels of TNF-alpha, IL-1beta, and CCL4 than the DQS alone group (P < 0.05). Tocopherols 23-26 tumor necrosis factor Mus musculus 223-232 34496685-7 2021 Furthermore, the 0.01% TCP mixture group also showed higher tear film lipid layer grades and conjunctival goblet cell density and lower corneal fluorescein staining scores, number of CD4 + IFN-gamma+ T cells, and levels of TNF-alpha, IL-1beta, and CCL4 than the DQS alone group (P < 0.05). Tocopherols 23-26 interleukin 1 alpha Mus musculus 234-242 34496685-7 2021 Furthermore, the 0.01% TCP mixture group also showed higher tear film lipid layer grades and conjunctival goblet cell density and lower corneal fluorescein staining scores, number of CD4 + IFN-gamma+ T cells, and levels of TNF-alpha, IL-1beta, and CCL4 than the DQS alone group (P < 0.05). Tocopherols 23-26 chemokine (C-C motif) ligand 4 Mus musculus 248-252 34471327-2 2021 The objective of this study was to use accelerated-solvent-extraction to achieve antioxidant extracts from chia seeds oils, enriched in tocopherols and tocotrienols, namely tocochromanols. Tocopherols 136-147 chitinase acidic Homo sapiens 107-111 34411781-2 2021 In our previous studies, we isolated five tocopherol biosynthesis genes from sweetpotato (Ipomoea batatas (L.) Lam) plants including 4-hydroxyphenylpyruvate dioxygenase (IbHPPD). Tocopherols 42-52 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 133-168 34710615-4 2022 Further, the impact of tocopherols and tocotrienols on COX-1/-2 or 5-LOX activity has not been fully delineated. Tocopherols 23-34 cytochrome c oxidase I, mitochondrial Rattus norvegicus 55-60 34710615-4 2022 Further, the impact of tocopherols and tocotrienols on COX-1/-2 or 5-LOX activity has not been fully delineated. Tocopherols 23-34 lysyl oxidase Rattus norvegicus 69-72 34710615-5 2022 In this study, we found that tocopherols and tocotrienols inhibited human recombinant COX-1 with IC50s of 1-12 microM, and suppressed COX-1-mediated formation of thromboxane in collagen-stimulated rat"s platelets with IC50s of 8-50 microM. Tocopherols 29-40 mitochondrially encoded cytochrome c oxidase I Homo sapiens 86-91 34710615-5 2022 In this study, we found that tocopherols and tocotrienols inhibited human recombinant COX-1 with IC50s of 1-12 microM, and suppressed COX-1-mediated formation of thromboxane in collagen-stimulated rat"s platelets with IC50s of 8-50 microM. Tocopherols 29-40 mitochondrially encoded cytochrome c oxidase I Homo sapiens 134-139 2745810-5 1989 The results show that intraperitoneal administration of vitamin E to dairy cows in an effective way of increasing plasma and milk tocopherol concentration. Tocopherols 130-140 Weaning weight-maternal milk Bos taurus 125-129 2508746-7 1989 However, when exogenous arachidonate was provided with A23187, intermediate amounts of dietary tocopherol (30 ppm) still suppressed the formation of 5-lipoxygenase products, but high doses (3000 ppm) did not have any additional inhibitory effect. Tocopherols 95-105 arachidonate 5-lipoxygenase Rattus norvegicus 149-163 2508746-8 1989 This differential response to high concentrations of vitamin E in the presence and absence of exogenous arachidonate highly suggest that at these concentrations, tocopherol may act principally at the level of substrate release whereas at lower concentrations, 5-lipoxygenase is inhibited. Tocopherols 162-172 arachidonate 5-lipoxygenase Rattus norvegicus 260-274 2529919-0 1989 [Study of thermo-stabilizing effect of tocopherol on rhodopsin in the presence of fatty acids using the method of differential scanning calorimetry]. Tocopherols 39-49 rhodopsin Homo sapiens 53-62 2529919-2 1989 Addition of tocopherol to photoreceptor membranes prevents the turbulent effect of the fatty acid on opsin and rhodopsin. Tocopherols 12-22 rhodopsin Homo sapiens 111-120 3777154-5 1986 Exogenous catalase, d-alpha-tocopherol, and particularly Trolox, the chroman compound of tocopherol, but not phytol, the fatty acid side chain of tocopherol, provided almost complete protection of the endothelial cells against a H2O2-mediated attack. Tocopherols 89-99 catalase Homo sapiens 10-18 3345752-3 1988 All the tocopherol homologues used, C1, C6, C11 and alpha-tocopherol, showed a similar fluorescence emission intensity at 325 nm in cyclohexane but were almost completely self-quenched by aggregation in water. Tocopherols 8-18 aldo-keto reductase family 1 member C4 Homo sapiens 44-47 3240710-5 1988 When the vehicle from which tocopherols had been extracted was used, CCl4 elicited about twice the levels of plasma ALT than when nonextracted corn oil was used. Tocopherols 28-39 chemokine (C-C motif) ligand 4 Mus musculus 69-73 3240710-5 1988 When the vehicle from which tocopherols had been extracted was used, CCl4 elicited about twice the levels of plasma ALT than when nonextracted corn oil was used. Tocopherols 28-39 glutamic pyruvic transaminase, soluble Mus musculus 116-119 2698101-0 1989 Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids. Tocopherols 0-10 phospholipase A and acyltransferase 1 Homo sapiens 39-54 3143417-7 1988 This observation is in direct contrast to the role of tocopherol, which has been shown to inhibit platelet and cardiac phospholipase A2 activity in rats, and to reduce thrombin-stimulated thromboxane release in rat platelets. Tocopherols 54-64 phospholipase A2 group IB Rattus norvegicus 119-135 3143417-7 1988 This observation is in direct contrast to the role of tocopherol, which has been shown to inhibit platelet and cardiac phospholipase A2 activity in rats, and to reduce thrombin-stimulated thromboxane release in rat platelets. Tocopherols 54-64 coagulation factor II, thrombin Homo sapiens 168-176 2966657-6 1987 By contrast tocopherol strongly potentiated the inductive effect of phenobarbital toward UDPGT activity (group I substrates) in rats fed the peroxidized fish oil. Tocopherols 12-22 UDP glucuronosyltransferase family 2 member B15 Rattus norvegicus 89-94 2966657-7 1987 The modification of the inductive effect of phenobarbital in combination with tocopherol on UDPGT activities was concomitant with an increase in seric transaminase activity and with a reverse effect as revealed from the study of the rate of fluorescent probes penetration in microsomes. Tocopherols 78-88 UDP glucuronosyltransferase family 2 member B15 Rattus norvegicus 92-97 7071827-4 1982 Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity. Tocopherols 0-10 carboxyl ester lipase Rattus norvegicus 51-71 3707988-7 1986 This partially purified rat platelet phospholipase A2 had an absolute requirement for Ca2+ and was inhibited by various forms of tocopherol. Tocopherols 129-139 phospholipase A2 group IIA Rattus norvegicus 28-53 3727630-3 1986 The tocopherol status was estimated by measuring the activities of creatine kinase and transaminases (GOT, GPT) in plasma as well as by in vitro hemolysis of erythrocytes. Tocopherols 4-14 glutamic--pyruvic transaminase Rattus norvegicus 107-110 3998153-7 1985 Heparin, which is known to prevent the binding of lipoprotein lipase to the cell surface membrane, abrogated the transfer of tocopherol to fibroblasts without altering the rate of triglyceride hydrolysis. Tocopherols 125-135 lipoprotein lipase Homo sapiens 50-68 6371455-2 1984 There is recent evidence that DMD is a functional tocopherol deficiency, with reduced levels of the lipoprotein required to carry tocopherol to tissues. Tocopherols 50-60 dystrophin Homo sapiens 30-33 6371455-4 1984 Thus DMD should follow the usual experience of other examples of oxidative pathology, where the balance between tocopherol, the main antioxidant in membrane lipids, and non protein-bound iron, an important catalyst of reactions which produce oxidizing free radicals, largely determines whether or not tissue damage occurs. Tocopherols 112-122 dystrophin Homo sapiens 5-8 6421635-2 1984 The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol. Tocopherols 23-33 linoleate 9S-lipoxygenase-4 Glycine max 35-47 6421635-2 1984 The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol. Tocopherols 23-33 linoleate 9S-lipoxygenase-4 Glycine max 115-127 3998153-0 1985 Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. Tocopherols 41-51 lipoprotein lipase Homo sapiens 12-30 3998153-1 1985 Lipoprotein lipase appears to function as the mechanism by which dietary vitamin E (tocopherol) is transferred from chylomicrons to tissues. Tocopherols 84-94 lipoprotein lipase Homo sapiens 0-18 3998153-3 1985 The studies presented here show that the in vitro addition of bovine milk lipoprotein lipase (lipase) to chylomicrons in the presence of human erythrocytes or fibroblasts (and bovine serum albumin [BSA]) resulted in the hydrolysis of the triglyceride and the transfer of both fatty acids and tocopherol to the cells; in the absence of lipase, no increase in cellular tocopherol was detectable. Tocopherols 292-302 lipoprotein lipase Homo sapiens 74-92 3998153-3 1985 The studies presented here show that the in vitro addition of bovine milk lipoprotein lipase (lipase) to chylomicrons in the presence of human erythrocytes or fibroblasts (and bovine serum albumin [BSA]) resulted in the hydrolysis of the triglyceride and the transfer of both fatty acids and tocopherol to the cells; in the absence of lipase, no increase in cellular tocopherol was detectable. Tocopherols 367-377 lipoprotein lipase Homo sapiens 74-92 3998153-6 1985 Addition of both lipase and its activator, apolipoprotein CII, resulted in a further increase in the cellular tocopherol content, but apolipoprotein CII alone had no effect. Tocopherols 110-120 apolipoprotein C2 Homo sapiens 43-61 6486081-3 1984 In contrast, similarly incubated LDL receptor-negative fibroblasts (from a patient with the homozygous form of familial hypercholesterolemia) only increased from 18 to 39 ng of tocopherol per mg. Estimation of the amount of LDL degraded from the cellular tocopherol uptake by normal cells yielded values virtually identical to the actual values of protein degradation as measured using 125I-LDL. Tocopherols 177-187 low density lipoprotein receptor Homo sapiens 33-45 7245692-0 1981 [Prophylactic action of tocopherol in CCl4 poisoning against a background of a varying water-soluble vitamin allowances]. Tocopherols 24-34 C-C motif chemokine ligand 4 Homo sapiens 38-42 7094301-1 1982 Tocopherols extracted from plasma with methanol or from platelets with chloroform/methanol were injected in methanol on a reversed-phase (C18) "high-performance" liquid-chromatographic column and eluted with water/methanol (2/98, by vol) at a flow rate of 1.4 mL/min. Tocopherols 0-11 Bardet-Biedl syndrome 9 Homo sapiens 138-141 6449955-3 1980 Tocopherol, instead, affects significantly only the DCCD sensitivity of ATPase. Tocopherols 0-10 dynein axonemal heavy chain 8 Homo sapiens 72-78 6254478-3 1980 When tocopherol was depleted from either the normal or high cholesterol diets, the following changes occurred in the arterial wall: (1) increase in thiobarbituric acid reactive substances; (2) decrease in lysosomal acid lipase and acid cholesteryl esterase; (3) decrease in the microsomal enzymes, acyl CoA synthetase, triglyceride synthesizing activity, cholesteryl ester synthesizing activity, neutral lipase and neutral cholesteryl esterase; and (4) increase in microsomal CPT. Tocopherols 5-15 lipase G, endothelial type Rattus norvegicus 220-226 6254478-3 1980 When tocopherol was depleted from either the normal or high cholesterol diets, the following changes occurred in the arterial wall: (1) increase in thiobarbituric acid reactive substances; (2) decrease in lysosomal acid lipase and acid cholesteryl esterase; (3) decrease in the microsomal enzymes, acyl CoA synthetase, triglyceride synthesizing activity, cholesteryl ester synthesizing activity, neutral lipase and neutral cholesteryl esterase; and (4) increase in microsomal CPT. Tocopherols 5-15 lipase A, lysosomal acid type Rattus norvegicus 236-256 6254478-3 1980 When tocopherol was depleted from either the normal or high cholesterol diets, the following changes occurred in the arterial wall: (1) increase in thiobarbituric acid reactive substances; (2) decrease in lysosomal acid lipase and acid cholesteryl esterase; (3) decrease in the microsomal enzymes, acyl CoA synthetase, triglyceride synthesizing activity, cholesteryl ester synthesizing activity, neutral lipase and neutral cholesteryl esterase; and (4) increase in microsomal CPT. Tocopherols 5-15 lipase G, endothelial type Rattus norvegicus 404-410 6254478-3 1980 When tocopherol was depleted from either the normal or high cholesterol diets, the following changes occurred in the arterial wall: (1) increase in thiobarbituric acid reactive substances; (2) decrease in lysosomal acid lipase and acid cholesteryl esterase; (3) decrease in the microsomal enzymes, acyl CoA synthetase, triglyceride synthesizing activity, cholesteryl ester synthesizing activity, neutral lipase and neutral cholesteryl esterase; and (4) increase in microsomal CPT. Tocopherols 5-15 lipase A, lysosomal acid type Rattus norvegicus 423-443 1186449-0 1975 Studies on tocopherol derivatives: V. Intestinal absorption of several d,1-3,4-3H2-alpha-tocopheryl esters in the rat. Tocopherols 11-21 histone cluster 3, H2a Rattus norvegicus 80-88 12754-2 1976 In the lung and liver of tocopherol-deficient rats, the activities of glutathione peroxidase and glucose 6-phosphate dehydrogenase were increased substantially, suggesting an important role for both enzymes in protecting the organ against the deleterious effects of lipid peroxides. Tocopherols 25-35 glucose-6-phosphate dehydrogenase Rattus norvegicus 97-130 31253014-2 1974 Cyclic-AMP phosphodiesterase is elevated in livers from tocopherol-deficient rats, which additionally have decreased glycogen and increased serine dehydratase. Tocopherols 56-66 serine dehydratase Rattus norvegicus 140-158 4287975-0 1966 Effects of digitonin and tocopherol on bovine heart muscle reduced diphosphopyridine nucleotide- and succinate-cytochrome c reductase and cytochrome c oxidase. Tocopherols 25-35 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 138-158 13773784-0 1961 Inhibition of succinoxidase by L-gulonolactone oxidase in liver preparations from tocopherol-deficient rats. Tocopherols 82-92 gulonolactone (L-) oxidase Rattus norvegicus 31-54 13818003-0 1959 Biopotency of non-tocopherol compounds in vit. Tocopherols 18-28 vitrin Homo sapiens 42-45 1210181-4 1975 The results of the experiments revealed some characteristic trends in the change of the cholinesterase activity occurring under the effect of vitamin E that depended upon a number of factors, such as: the dose of tocopherol, the sex of the animal, time of the year, the brain division under study and the seasonal dynamics of the initial activity. Tocopherols 213-223 butyrylcholinesterase Homo sapiens 88-102 1210181-5 1975 It is shown that in the brain sectors where a material difference existed in the cholinesterase activity between the control males and females it vanished under the effect of tocopherol. Tocopherols 175-185 butyrylcholinesterase Homo sapiens 81-95 20343879-0 1947 Effect of sugars, sugar alcohols and gastric mucin on utilization of tocopherol in muscular dystrophy. Tocopherols 69-79 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 37-50 13367022-2 1956 Lipide cofactor replaceable by tocopherol for the enzymatic reduction of cytochrome c. Tocopherols 31-41 cytochrome c, somatic Homo sapiens 73-85 13018916-0 1952 [New studies on tocopherol; correlation with progesterones, organotropic action in inanition and effect on distribution of fats]. Tocopherols 16-26 chromosome 10 open reading frame 90 Homo sapiens 123-127 33851473-1 2021 Phospholipid transfer protein (PLTP) is a complex glycosylated protein that mediates the transfer of phospholipids, unesterified cholesterol, diacylglycerides, specific apolipoproteins, and tocopherols between different classes of lipoproteins as well as between lipoproteins and cells. Tocopherols 190-201 phospholipid transfer protein Homo sapiens 0-29 33851473-1 2021 Phospholipid transfer protein (PLTP) is a complex glycosylated protein that mediates the transfer of phospholipids, unesterified cholesterol, diacylglycerides, specific apolipoproteins, and tocopherols between different classes of lipoproteins as well as between lipoproteins and cells. Tocopherols 190-201 phospholipid transfer protein Homo sapiens 31-35 33179365-6 2021 Transgenic tomatoes showed moderate increments in tocopherols (up to ~ 20%) and a massive accumulation of tocotrienols (up to ~ 3,400%). Tocopherols 50-61 AT3 protein Solanum lycopersicum 2-3 33682309-10 2021 In the present study, Agrobacterium-mediated transformation of Indica rice ASD16 with two genes involved in tocopherol biosynthesis, viz., TC and HPT were carried out and the transgenic plants were analyzed for the vitamin E (alpha- tocopherol) content. Tocopherols 108-118 homogentisate phytyltransferase 1 Arabidopsis thaliana 146-149 33499140-0 2021 Protective Role of Natural and Semi-Synthetic Tocopherols on TNFalpha-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells. Tocopherols 46-57 tumor necrosis factor Homo sapiens 61-69 33499140-4 2021 The results show that all tocopherol containing derivatives used, prevented TNFalpha-induced oxidative stress and the increase of ICAM-1 and Cl-2 expression, and that (delta-Toc)2S and (delta-Toc)2S2 are more effective than delta-Toc and alpha-Toc. Tocopherols 26-36 tumor necrosis factor Homo sapiens 76-84 33499140-4 2021 The results show that all tocopherol containing derivatives used, prevented TNFalpha-induced oxidative stress and the increase of ICAM-1 and Cl-2 expression, and that (delta-Toc)2S and (delta-Toc)2S2 are more effective than delta-Toc and alpha-Toc. Tocopherols 26-36 intercellular adhesion molecule 1 Homo sapiens 130-136 33499140-4 2021 The results show that all tocopherol containing derivatives used, prevented TNFalpha-induced oxidative stress and the increase of ICAM-1 and Cl-2 expression, and that (delta-Toc)2S and (delta-Toc)2S2 are more effective than delta-Toc and alpha-Toc. Tocopherols 26-36 claudin 2 Homo sapiens 141-145 33499140-7 2021 Since ICAM-1 and Cl-2 increase intestinal bowel diseases, and cause excessive recruitment of immune cells and alteration of the intestinal barrier, natural and, above all, semi-synthetic tocopherols may have a potential role as a therapeutic support against intestinal chronic inflammation, in which TNFalpha represents an important proinflammatory mediator. Tocopherols 187-198 intercellular adhesion molecule 1 Homo sapiens 6-12 33499140-7 2021 Since ICAM-1 and Cl-2 increase intestinal bowel diseases, and cause excessive recruitment of immune cells and alteration of the intestinal barrier, natural and, above all, semi-synthetic tocopherols may have a potential role as a therapeutic support against intestinal chronic inflammation, in which TNFalpha represents an important proinflammatory mediator. Tocopherols 187-198 claudin 2 Homo sapiens 17-21 33499140-7 2021 Since ICAM-1 and Cl-2 increase intestinal bowel diseases, and cause excessive recruitment of immune cells and alteration of the intestinal barrier, natural and, above all, semi-synthetic tocopherols may have a potential role as a therapeutic support against intestinal chronic inflammation, in which TNFalpha represents an important proinflammatory mediator. Tocopherols 187-198 tumor necrosis factor Homo sapiens 300-308 33184329-9 2020 Quantification of lipid and protein hydroperoxide from the wild type and tocopherol deficient (vte1) mutant Arabidopsis leaves using a colorimetric ferrous oxidation-xylenol orange assay reveals that alpha-tocopherol prevents formation of both lipid and protein hydroperoxides at high light. Tocopherols 73-83 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 95-99 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. Tocopherols 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 33211827-4 2020 Using in vitro erythroid differentiation, we show here that GPX4-irreversible inhibition by 1S,3R-RSL3 (RSL3) and its short hairpin RNA-mediated knockdown strongly impaired enucleation in a ferroptosis-independent manner not restored by tocopherol or iron chelators. Tocopherols 237-247 glutathione peroxidase 4 Homo sapiens 60-64 32897507-7 2020 Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). Tocopherols 17-27 carbohydrate sulfotransferase 10 Rattus norvegicus 59-63 32897507-7 2020 Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). Tocopherols 17-27 mercaptopyruvate sulfurtransferase Homo sapiens 65-69 32897507-7 2020 Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). Tocopherols 17-27 carbohydrate sulfotransferase 10 Rattus norvegicus 98-102 32897507-7 2020 Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). Tocopherols 17-27 mercaptopyruvate sulfurtransferase Homo sapiens 198-202 32897507-7 2020 Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). Tocopherols 17-27 sulfotransferase family 1E member 1 Homo sapiens 208-233 32289484-2 2020 Here, the targeting nanovesicles were developed by synthesizing tocopherol-SS-DM1 and conjugating a pH low insertion peptide (pHLIP) to PEGylated phospholipids, in which tocopherol-SS-DM1 improves the drug loading and is glutathione responsive in the cytoplasm, meanwhile, the pH insertion peptide targets the acidic microenvironment of cancer cells. Tocopherols 170-180 DM1 protein kinase Homo sapiens 184-187 32553494-1 2020 Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with beta-cyclodextrin (beta-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system. Tocopherols 190-200 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 112-119 32289484-2 2020 Here, the targeting nanovesicles were developed by synthesizing tocopherol-SS-DM1 and conjugating a pH low insertion peptide (pHLIP) to PEGylated phospholipids, in which tocopherol-SS-DM1 improves the drug loading and is glutathione responsive in the cytoplasm, meanwhile, the pH insertion peptide targets the acidic microenvironment of cancer cells. Tocopherols 64-74 DM1 protein kinase Homo sapiens 78-81 32052951-2 2020 Using the CEAP classification as a special theme, a symposium entitled "CEAP Clinical Classes C0S-C4: Differences, Similarities and Place of Ruscus+HMC+VitC in Treating Patients with CVD" was held at the annual meeting of the 2019 European Venous Forum. Tocopherols 152-156 biogenesis of lysosomal organelles complex 1 subunit 2 Homo sapiens 72-76 31482084-1 2019 4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a significant enzyme in the biosynthesis of plastoquinone and tocopherol. Tocopherols 108-118 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 0-35 32068963-5 2020 Accordingly, PHYB2Y252H -overexpressing fruits developed more chloroplasts containing voluminous grana at the green stage and overaccumulated carotenoids, tocopherols, flavonoids and ascorbate in ripe fruits compared to both wildtype and PHYB2-overexpressing lines. Tocopherols 155-166 phytochrome B2 Solanum lycopersicum 13-18 31673914-4 2020 alpha-Tocopherol is synthesized from gamma-tocopherol by gamma-tocopherol methyltransferase (gamma-TMT, VTE4) in the final step of the tocopherol biosynthetic pathway. Tocopherols 43-53 Probable tocopherol O-methyltransferase, chloroplastic Zea mays 57-91 31673914-4 2020 alpha-Tocopherol is synthesized from gamma-tocopherol by gamma-tocopherol methyltransferase (gamma-TMT, VTE4) in the final step of the tocopherol biosynthetic pathway. Tocopherols 43-53 Probable tocopherol O-methyltransferase, chloroplastic Zea mays 93-102 31673914-10 2020 These results show that it is feasible to overexpress ZmTMT to optimize the tocopherol composition in maize; such a corn product might be useful in the feed industry in the near future. Tocopherols 76-86 Probable tocopherol O-methyltransferase, chloroplastic Zea mays 54-59 31856862-21 2019 The usefulness of the BS-II system is demonstrated in the case of biomechanical analysis of the implantation of LUMIR XLIF CAGE implant to a human cadaver specimen of the spine. Tocopherols 22-27 DEAD-box helicase 53 Homo sapiens 123-127 31169939-0 2019 An allele of ZmPORB2 encoding a protochlorophyllide oxidoreductase promotes tocopherol accumulation in both leaves and kernels of maize. Tocopherols 76-86 oxidoreductase Zea mays 52-66 31203808-12 2020 GLTP had higher affinity for tocotrienols than tocopherols. Tocopherols 47-58 glycolipid transfer protein Homo sapiens 0-4 31733517-2 2019 Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED), with proprioceptive deficits and somatosensory degeneration arising from dorsal root ganglia neurons (DRGNs). Tocopherols 55-65 alpha tocopherol transfer protein Homo sapiens 84-88 31733517-2 2019 Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED), with proprioceptive deficits and somatosensory degeneration arising from dorsal root ganglia neurons (DRGNs). Tocopherols 55-65 alpha tocopherol transfer protein Homo sapiens 140-144 31717650-10 2019 Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Tocopherols 5-13 aldo-keto reductase family 1 member B1 Rattus norvegicus 135-151 31717650-12 2019 Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. Tocopherols 74-82 aldo-keto reductase family 1 member B Homo sapiens 36-52 31515446-5 2019 The pathogen-inducible biosynthesis of tocopherols is promoted by the immune regulators ENHANCED DISEASE SUSCEPTIBILITY1 and PHYTOALEXIN-DEFICIENT4. Tocopherols 39-50 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 125-147 30945368-1 2019 4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the second reaction in the tyrosine catabolism and is linked to the production of cofactors plastoquinone and tocopherol in plants. Tocopherols 163-173 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 0-35 30945368-1 2019 4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the second reaction in the tyrosine catabolism and is linked to the production of cofactors plastoquinone and tocopherol in plants. Tocopherols 163-173 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 37-41