PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28589517-6	2018	1-octanol and carbenoxolone increased the glutamate uptake by astrocytes and glutamate aspartate transporter (GLAST) expression on the cell membrane.	1-Octanol	0-9	solute carrier family 1 member 3	Rattus norvegicus	77-108
29439514-6	2018	Then, n-octanol and 2-octanone were selected as extracts to remove HQ, BQ and CAB from the used electrolyte solution.	1-Octanol	6-15	neural proliferation, differentiation and control 1	Homo sapiens	78-81
28589517-6	2018	1-octanol and carbenoxolone increased the glutamate uptake by astrocytes and glutamate aspartate transporter (GLAST) expression on the cell membrane.	1-Octanol	0-9	solute carrier family 1 member 3	Rattus norvegicus	110-115
23109246-4	2013	Here, we find that in simulations the OPLS-AA force field parameters (with fixed charges) can reproduce solvation free energies of solutes in 1-octanol with AAD of about half that for the solute hydration free energies using a extended simple point charge (SPC/E) model of water.	1-Octanol	142-151	proline rich protein gene cluster	Homo sapiens	257-260
27552904-5	2016	The Distribution coefficients at pH7.00 (DpH7) of atenolol, atenolol + brilliant blue and atenolol + bromophenol blue were experimentally determined in n-octanol.	1-Octanol	152-161	diphthamide biosynthesis 7	Rattus norvegicus	41-45
25212695-6	2014	We have used atomistic molecular dynamics simulations to reveal that flexible electrostatic and zinc-binding loops in apo-SOD1 dimers play a critical role in the binding of 1-octanol clusters and phospholipid bilayer, without any significant unfolding of the protein.	1-Octanol	173-182	superoxide dismutase 1	Homo sapiens	122-126
22833363-6	2012	The associated efficiency of the phospholipids and insulin can be up to 100% when their mass ratio is 7.5 : 1 or more, and the solubility of the complex is improved more than 40 000 times compared with that of insulin alone in the n-octyl alcohol.	1-Octanol	231-246	insulin	Homo sapiens	51-58
23176753-3	2013	Dicarba bridges were rationally introduced into minimized analogs of GAL and NPY resulting in increased alpha-helical content, in vitro metabolic stability and n-octanol/water partitioning coefficient (logD).	1-Octanol	160-169	galanin and GMAP prepropeptide	Mus musculus	69-72
23176753-3	2013	Dicarba bridges were rationally introduced into minimized analogs of GAL and NPY resulting in increased alpha-helical content, in vitro metabolic stability and n-octanol/water partitioning coefficient (logD).	1-Octanol	160-169	neuropeptide Y	Mus musculus	77-80
22833363-6	2012	The associated efficiency of the phospholipids and insulin can be up to 100% when their mass ratio is 7.5 : 1 or more, and the solubility of the complex is improved more than 40 000 times compared with that of insulin alone in the n-octyl alcohol.	1-Octanol	231-246	insulin	Homo sapiens	210-217
22222967-6	2012	In whole-cell patch-clamp recordings, higher alcohols (1-hexanol to 1-octanol) activated hTRPA1 and the potency increased with the carbon chain length.	1-Octanol	68-77	transient receptor potential cation channel subfamily A member 1	Homo sapiens	89-95
19846748-3	2010	We found that 1-octanol inhibited native T-currents at subanesthetic concentrations with an IC(50) of approximately 4 muM.	1-Octanol	14-23	latexin	Homo sapiens	118-121
21798257-8	2011	The activity of class III alcohol dehydrogenase was measured by the photometric method with n-octanol and class IV with m-nitrobenzaldehyde as a substrate.	1-Octanol	92-101	aldo-keto reductase family 1 member A1	Homo sapiens	26-47
21112594-6	2011	They ranged from 0.026 cm2 min-1 for 1,1-dichloroethylene to 0.605 cm2 min-1 for n-octanol.	1-Octanol	81-90	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
20209143-0	2010	The C. elegans D2-like dopamine receptor DOP-3 decreases behavioral sensitivity to the olfactory stimulus 1-octanol.	1-Octanol	106-115	Dopamine receptor 3	Caenorhabditis elegans	41-46
19846748-4	2010	In contrast, 1-octanol was up to 30-fold less potent in inhibiting recombinant Ca(V)3.3 T-channels heterologously expressed in human embryonic kidney cells.	1-Octanol	13-22	caveolin 3	Homo sapiens	79-85
18814882-1	2008	In this study, we show that the addition of n-octanol to the mobile phase improves the chromatographic determination of lipophilicity parameters of xenobiotics (neutral solutes, acidic, neutral and basic drugs) on a Phenomenex Gemini C18 column.	1-Octanol	44-53	Bardet-Biedl syndrome 9	Homo sapiens	234-237
18608794-1	2009	Polysulphone (PSF) microcapsules containing 1-octanol were prepared with solvent extraction method for the recovery of caprolactam.	1-Octanol	44-53	insulin like growth factor binding protein 7	Homo sapiens	14-17
18608794-10	2009	Considering extraction capacity and extractant loss in the preparation process, it is suggested that PSF microcapsules containing 1-octanol should be prepared with the two-step process.	1-Octanol	130-139	insulin like growth factor binding protein 7	Homo sapiens	101-104
18095160-8	2008	The activity of class III alcohol dehydrogenase was measured by the photometric method with n-octanol and class IV with m-nitrobenzaldehyde as a substrate.	1-Octanol	92-101	aldo-keto reductase family 1 member A1	Homo sapiens	26-47
16530269-1	2006	The n-octanol/water partition coefficient, logP(o/w), for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatography (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases.	1-Octanol	4-13	Bardet-Biedl syndrome 9	Homo sapiens	195-198
17211707-8	2007	The activity of class III ADH was measured by the photometric method with n-octanol and class IV with m-nitrobenzaldehyde as a substrate.	1-Octanol	74-83	aldo-keto reductase family 1 member A1	Homo sapiens	26-29
17441143-4	2007	The spin-transition temperature was tuned over a wide range by adding a small amount of 1-octanol, a scavenger for hydrogen-bonding interactions.	1-Octanol	88-97	spindlin 1	Homo sapiens	4-8
16920127-2	2006	In this procedure, long-chain fatty acids (C(14), C(16) and C(18)) were converted into their ion-pair complexes with tetrabutylammonium hydrogen sulfate and then extracted by organic solvent (1-octanol) impregnated in the hollow fiber.	1-Octanol	192-201	Bardet-Biedl syndrome 9	Homo sapiens	60-65
17719594-6	2007	At physiological pH, 1:1 correlation was obtained between logD(7.4) and logk(w)(oct) indices upon addition of 0.25% n-octanol, in the case of weak acids.	1-Octanol	116-125	plexin A2	Homo sapiens	80-83
16643870-5	2006	The resulting disaccharide fluoride was readily activated by hafnocene bistrifluoromethanesulfonate [Cp2Hf(OTf)2] and glycosidated with n-octanol.	1-Octanol	136-145	POU class 2 homeobox 2	Homo sapiens	101-112
14596404-1	2003	A new type of ether-bonded packing for reversed-phase HPLC (RP-HPLC) was synthesized by reacting 1-octanol with beta-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, followed by coupling the product onto porous silica.	1-Octanol	97-106	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-121
15285844-6	2004	The presence of the galloyl moiety on the C-ring markedly increased the n-octanol/PBS partition coefficients of the catechins and their activity on P-gp.	1-Octanol	72-81	ATP binding cassette subfamily B member 1	Homo sapiens	148-152
15963648-10	2005	These observations were also replicated with a different ethanol antagonist, 1-octanol, in area CA1.	1-Octanol	77-86	carbonic anhydrase 1	Rattus norvegicus	96-99
15506724-1	2004	The rational design of catechol bis-amides rendered molecular structures that fold into beta-turn mimics at the interface of HOPG and 1-octanol as demonstrated by STM.	1-Octanol	134-143	sulfotransferase family 1A member 3	Homo sapiens	163-166
15182202-4	2004	In the absence of phorbol ester or diacylglycerol, 1-octanol potently activated PKCalpha in a concentration-dependent manner, while 1-heptanol was completely without effect, despite differing by one methylene unit.	1-Octanol	51-60	protein kinase C alpha	Homo sapiens	80-88
14757500-8	2004	The multiple linear regression for effectiveness of methylxanthines in reversal of P-gp mediated MDR of L1210/VCR cells (expressed as respective IC(50r) values) has been computed, with molar weight: M(w), molar volume: V(M), molar refractivity: R(M), crystal density: d and partition coefficient n-octanol/water: logP as descriptors.	1-Octanol	296-305	phosphoglycolate phosphatase	Mus musculus	83-87
15356719-1	2004	The extracting agent 2,6-bis(4,6-di-pivaloylamino-1,3,5-triazin-2-yl)-pyridine (L(5)) in n-octanol was found, in synergy with 2-bromodecanoic acid, to give D(Am)/D(Eu) separation factors (SFs) between 2.4 and 3.7 when used to extract the metal ions from 0.02-0.12 M HNO(3).	1-Octanol	89-98	ribosomal protein L5	Homo sapiens	80-84
12499594-2	2002	The use of log k derived from reversed phase (RP)-HPLC retention times provides a convenient method for estimating log P(oct) values (P(oct): 1-octanol/water partition coefficient).	1-Octanol	142-151	plexin A2	Homo sapiens	121-124
12047107-6	2002	Of the identified compounds, maltol, 5-hydroxymethyl furfuraldehyde, dihydrodihydroxypyranone, 1,3-butanediol and 1-octanol were identified only in desi ghee volatiles.	1-Octanol	114-123	desumoylating isopeptidase 2	Homo sapiens	148-152
12141816-6	2002	The activity of class III alcohol dehydrogenase was measured by the photometric method with n-octanol and class IV with m-nitrobenzaldehyde as a substrate, respectively.	1-Octanol	92-101	aldo-keto reductase family 1 member A1	Homo sapiens	26-47
11821009-4	2002	The biological relevance of this model was checked with respect on the one hand, to the close relationship between the log of drug permeability coefficient normalized to molecular weight and the log of the 1-octanol/water partition coefficient, and on the other hand to the functional P-glycoprotein (P-gp) expression.	1-Octanol	206-215	ATP binding cassette subfamily B member 1	Homo sapiens	301-305
11560872-9	2001	Linear correlation analyses between UGT1A4 kinetics and substrate physicochemical parameters showed significant correlation between V(max) and both the partition coefficient (log P, n-octanol/water) and pK(a) and between K(m) and pK(a), thereby indicating that the lipophilicity and the ease of availability of the tertiary amine lone pair of electrons of the substrate are important with respect to enzyme catalysis.	1-Octanol	182-191	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	36-42
11826958-4	2001	Furthermore, the order of the partition coefficients of catechins in an n-octanol/PBS system is the same as that of the amount incorporated into liposomes.	1-Octanol	72-81	cholinergic receptor muscarinic 3	Homo sapiens	82-85
10434802-3	1999	The interactions of GK2 with various drugs were investigated using the 1-octanol/water partition method.	1-Octanol	71-80	glycerol kinase 2	Rattus norvegicus	20-23
10725368-9	2000	1-Octanol also antagonized ethanol inhibition of BMP-7 morphogenesis in NG108-15 cells.	1-Octanol	0-9	bone morphogenetic protein 7	Mus musculus	49-54
9795088-4	1998	Using this simple physicochemical approach, the permeability of a compound through Caco-2 cells by passive diffusion can be predicted from the compounds" distribution coefficient in 1-octanol/water (log D(oct)) and its molecular weight (MW).	1-Octanol	182-191	plexin A2	Homo sapiens	199-209
18967245-5	1998	Silver(I) was extracted with TTCTOHA into octan-1-ol as AgL and Ag(2)L(2).	1-Octanol	42-52	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	56-59
9454604-3	1998	The aldehyde binding site of aldose reductase appears to be 1.4 times more hydrophobic than n-octanol and can accommodate a linear alkyl chain with at least seven methylene groups (approximately 14 A in length).	1-Octanol	92-101	aldo-keto reductase family 1 member B	Homo sapiens	29-45
9140137-7	1997	The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8.	1-Octanol	45-54	Rac family small GTPase 2	Rattus norvegicus	29-32
9247722-3	1997	All 3 probes had high n-octanol/buffer partition coefficients and gave 2 signal components in in vivo ESR spectra at head of living mice after intravenous injection.	1-Octanol	22-31	esterase 5 regulator	Mus musculus	102-105
2265195-3	1990	The results indicate that the initial rate of hydrolysis of PC by PLA2 is increased by all the n-alcohols but in a chain-length dependent manner and that the maximum rate occurs at n = 8 (octan-1-ol).	1-Octanol	188-198	phospholipase A2 group IB	Homo sapiens	66-70
8300349-1	1994	PURPOSE: This study was performed to determine whether the junctions between both the epithelial and the differentiating fiber-like cells of ovine lens cultures, like gap junctions in other tissues, exhibit cell-to-cell communication that is inhibited by n-octanol, and to determine whether lens connexins and the fiber cell membrane proteins MP20 and MP26 are expressed by these ovine lens cell cultures.	1-Octanol	255-264	lens intrinsic membrane protein 2	Homo sapiens	343-347
8300349-1	1994	PURPOSE: This study was performed to determine whether the junctions between both the epithelial and the differentiating fiber-like cells of ovine lens cultures, like gap junctions in other tissues, exhibit cell-to-cell communication that is inhibited by n-octanol, and to determine whether lens connexins and the fiber cell membrane proteins MP20 and MP26 are expressed by these ovine lens cell cultures.	1-Octanol	255-264	major intrinsic protein of lens fiber	Homo sapiens	352-356
1432622-4	1992	The values obtained could be correlated with the values for n-octanol-water partition taken from the literature by an approach based on the linear solvation relationship: log P1 = a log P2 + b; in this relationship, a and b are constants and P1 and P2 correspond to the two different organic and aqueous phase partition equilibria.	1-Octanol	60-69	crystallin gamma F, pseudogene	Homo sapiens	242-251
1327187-2	1992	The solubility of myeloperoxidase in 1-octanol and octanol was determined.	1-Octanol	37-46	myeloperoxidase	Rattus norvegicus	18-33
1649465-4	1991	The NaK-ATPase increased significantly in the B fraction response of the olfactory main concha with 1 x 10(-3) M of 1-octanol but NaK-ATPase declined significantly in the presence of 1 x 10(-3) M of 1-nonanol.	1-Octanol	116-125	ATPase Na+/K+ transporting subunit alpha 1	Gallus gallus	4-14
34955206-5	2022	The RS results demonstrated that the n-octanol addition and higher engine speed led to a larger D1-FWHM (D1-full width at half maximum), AD1/AT (area ratio of D1 band and the total spectral) and AD3/AT (area ratio of D3 band and the total spectral) as well as a smaller La (crystallite width), revealing a lower degree of graphitization.	1-Octanol	37-46	amyloid beta precursor protein	Homo sapiens	137-140
34955206-5	2022	The RS results demonstrated that the n-octanol addition and higher engine speed led to a larger D1-FWHM (D1-full width at half maximum), AD1/AT (area ratio of D1 band and the total spectral) and AD3/AT (area ratio of D3 band and the total spectral) as well as a smaller La (crystallite width), revealing a lower degree of graphitization.	1-Octanol	37-46	presenilin 1	Homo sapiens	195-198
35209010-7	2022	Finally, time-evolution methods, namely classical molecular dynamics (MD) and Car-Parrinello Molecular Dynamics (CPMD) were employed to shed light onto dynamical nature of liquid n-octanol with emphasis put on metric and vibrational features.	1-Octanol	179-188	CXADR pseudogene 1	Homo sapiens	78-81
34251523-1	2021	A multiple linear regression model called MLR-3 is used for predicting the experimental n-octanol/water partition coefficient (log PN) of 22 N-sulfonamides proposed by the organizers of the SAMPL7 blind challenge.	1-Octanol	88-97	CD69 molecule	Homo sapiens	42-47
34251523-4	2021	Overall, the results support the appropriateness of multiple linear regression approach MLR-3 for computing the n-octanol/water partition coefficient in sulfonamide-bearing compounds.	1-Octanol	112-121	CD69 molecule	Homo sapiens	88-93
34199635-7	2021	Here, the hydrophilicity and the GRP receptor binding affinities were found to be especially strongly influenced by the number of negative charges and peptide copies, showing logD (1-octanol-water-distribution coefficient) and IC50 (half maximal inhibitory concentration) values of -2.2 +- 0.1 and 59.1 +- 1.5 nM for the homodimer, and -1.9 +- 0.1 and 99.8 +- 3.2 nM for the homotetramer, respectively.	1-Octanol	181-190	gastrin releasing peptide	Homo sapiens	33-36
34199635-7	2021	Here, the hydrophilicity and the GRP receptor binding affinities were found to be especially strongly influenced by the number of negative charges and peptide copies, showing logD (1-octanol-water-distribution coefficient) and IC50 (half maximal inhibitory concentration) values of -2.2 +- 0.1 and 59.1 +- 1.5 nM for the homodimer, and -1.9 +- 0.1 and 99.8 +- 3.2 nM for the homotetramer, respectively.	1-Octanol	181-190	superoxide dismutase 1	Homo sapiens	321-340
2806555-3	1989	Formaldehyde dehydrogenase was found to be able at high pH values to catalyze the NAD-dependent oxidation of long-chain aliphatic alcohols like n-octanol and 12-hydroxydodecanoate but ethanol was used only at very high substrate concentrations and pyrazole was not inhibitory.	1-Octanol	144-153	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-26
1101546-5	1975	With either 1-octanol or ethanol as substrate, a marked elevation of ADH activity was observed beginning with day 7 post inoculation in rat livers infected with T. cruzi, T. lewisi, and T. congolense, or as early as day 4 post inoculation with T. rhodesiense.	1-Octanol	12-21	aldo-keto reductase family 1 member A1	Rattus norvegicus	69-72
33291901-6	2020	In this work, we report studies on the structure and transport properties of mixtures of 1-octanol with the IL trihexyltetradecylphosphonium bis(trifluoromethylsulfonyl)imide (P6,6,6,14 +/NTf2 -).	1-Octanol	89-98	nuclear transport factor 2	Homo sapiens	188-192
33724853-6	2021	An oxygen-quenchable triplet state (T1) of AI3 was produced upon 416 nm excitation in both water and n-octanol.	1-Octanol	101-110	family with sequence similarity 83 member H	Homo sapiens	43-46