PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 16134950-3 2005 A series of novel benzothiepines (3R,3R"-2,3,4,5-tetrahydro-5-aryl-1-benzothiepin-4-ol 1,1-dioxides) were synthesized and tested for their ability to inhibit the apical sodium dependent bile acid transport (ASBT)-mediated uptake of [(14)C]taurocholate (TC) in H14 cells. benzothiepines 18-32 solute carrier family 10 member 2 Homo sapiens 207-211 16134951-4 2005 A series of benzothiepines were prepared to refine the structure-activity relationship of the substituted phenyl ring at the 5-position of benzothiepine ring and to identify potent, crystalline, nonhygroscopic, and efficacious ASBT inhibitors with low systemic exposure. benzothiepines 12-26 solute carrier family 10 member 2 Homo sapiens 227-231