PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33992733-0	2021	Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2",3,4,4",5,5"-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats.	Dioxins	84-90	pyruvate carboxylase	Rattus norvegicus	134-137
33864839-1	2021	PCB 180 is a typical non-dioxin-like polychlorinated biphenyl (NDL-PCB).	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	0-3
33563076-13	2021	In conclusion, the developed method will be used to screen AhR receptor responsive xenobiotics by observing the color change in RT-LAMP assay like dioxin used in the present study.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	59-62
33992733-1	2021	PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB).	Dioxins	41-47	pyruvate carboxylase	Rattus norvegicus	0-3
33992733-1	2021	PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB).	Dioxins	41-47	pyruvate carboxylase	Rattus norvegicus	53-56
33963922-0	2021	Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.	Dioxins	121-127	aryl-hydrocarbon receptor	Mus musculus	23-48
34052195-1	2021	2,3,7,8-Tetrachlorodibenzo-p-dioxin (dioxin; TCDD) is an environmental contaminant that elicits a variety of toxic effects, many of which are mediated through activation of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	177-202
34052195-1	2021	2,3,7,8-Tetrachlorodibenzo-p-dioxin (dioxin; TCDD) is an environmental contaminant that elicits a variety of toxic effects, many of which are mediated through activation of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	204-207
34023604-1	2021	2,3",4,4",5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.	Dioxins	45-51	pyruvate carboxylase	Homo sapiens	33-36
33963922-1	2021	The aryl hydrocarbon receptor (AhR) acts as a receptor that responds to ligands, including dioxin.	Dioxins	91-97	aryl-hydrocarbon receptor	Mus musculus	4-29
33963922-1	2021	The aryl hydrocarbon receptor (AhR) acts as a receptor that responds to ligands, including dioxin.	Dioxins	91-97	aryl-hydrocarbon receptor	Mus musculus	31-34
33963922-3	2021	Because dioxin exposure impairs cognitive and neurobehavioral functions, AhR-expressing neurons need to be identified for elucidation of the dioxin neurotoxicity mechanism.	Dioxins	141-147	aryl-hydrocarbon receptor	Mus musculus	73-76
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	151-157	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	39-45
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	151-157	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	47-53
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	151-157	aryl-hydrocarbon receptor repressor	Mus musculus	59-63
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	151-157	aryl-hydrocarbon receptor	Mus musculus	201-204
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	184-190	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	39-45
33922941-1	2021	Dioxins have been suggested to induce inflammation in the intestine and brain and to induce neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), partly due to deficits in parvalbumin-positive neurons in the brain that are sensitive to inflammatory stress.	Dioxins	0-7	parvalbumin	Homo sapiens	239-250
33893898-2	2021	The AhR was cloned and characterized for its role in mediating the toxicity of dioxins.	Dioxins	79-86	aryl hydrocarbon receptor	Homo sapiens	4-7
33849548-10	2021	Comparing whole blood data to a study of dioxin exposed adults from Alabama identified a CpG within the gene SMO that was hypomethylated with dioxin exposure in both studies.	Dioxins	41-47	smoothened, frizzled class receptor	Homo sapiens	109-112
33936062-5	2021	Moreover, BaP exposure alone or co-exposure with Der f 1-induced aryl hydrocarbon receptor (AhR) activity was determined by using an AhR-dioxin-responsive element reporter plasmid.	Dioxins	137-143	aryl hydrocarbon receptor	Homo sapiens	65-90
33936062-5	2021	Moreover, BaP exposure alone or co-exposure with Der f 1-induced aryl hydrocarbon receptor (AhR) activity was determined by using an AhR-dioxin-responsive element reporter plasmid.	Dioxins	137-143	aryl hydrocarbon receptor	Homo sapiens	92-95
33849548-10	2021	Comparing whole blood data to a study of dioxin exposed adults from Alabama identified a CpG within the gene SMO that was hypomethylated with dioxin exposure in both studies.	Dioxins	142-148	smoothened, frizzled class receptor	Homo sapiens	109-112
33840024-7	2021	For other six dioxins/furans, AGMs increased over KF-1 through KF-3A but then decreased for KF-3B/4, for example, 1,2,3,4,6,7,8-heptachlorodibenzofuran for males, and AGMs for KF-1, KF-2, KF-3A, and KF-3B/4 were 7.9, 8.4, 10.7, and 7.5 fg/g lipid, respectively.	Dioxins	14-21	ring finger protein 103	Homo sapiens	50-54
33513480-0	2021	Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	94-97
33711284-0	2021	Attenuation of growth hormone production at the fetal stage is critical for dioxin-induced developmental disorder in rat offspring.	Dioxins	76-82	gonadotropin releasing hormone receptor	Rattus norvegicus	15-29
33711284-2	2021	Our previous studies in rat fetuses revealed that maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly-toxic dioxin, suppresses fetal synthesis of pituitary growth hormone (GH) that is essential for development.	Dioxins	100-106	gonadotropin releasing hormone receptor	Rattus norvegicus	178-192
33711284-2	2021	Our previous studies in rat fetuses revealed that maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly-toxic dioxin, suppresses fetal synthesis of pituitary growth hormone (GH) that is essential for development.	Dioxins	100-106	gonadotropin releasing hormone receptor	Rattus norvegicus	194-196
33711284-11	2021	These results provide a novel evidence that dioxin suppresses GH-producing cell proliferation and GH synthesis due to partly targeting DAPL1, thereby impairing offspring development.	Dioxins	44-50	gonadotropin releasing hormone receptor	Rattus norvegicus	62-64
33711284-11	2021	These results provide a novel evidence that dioxin suppresses GH-producing cell proliferation and GH synthesis due to partly targeting DAPL1, thereby impairing offspring development.	Dioxins	44-50	gonadotropin releasing hormone receptor	Rattus norvegicus	98-100
33711284-11	2021	These results provide a novel evidence that dioxin suppresses GH-producing cell proliferation and GH synthesis due to partly targeting DAPL1, thereby impairing offspring development.	Dioxins	44-50	death associated protein-like 1	Rattus norvegicus	135-140
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	184-190	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	47-53
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	184-190	aryl-hydrocarbon receptor repressor	Mus musculus	59-63
33963922-9	2021	Additionally, the expression levels of Cyp1a1, Cyp1b1, and Ahrr genes in the brain, a surrogate of TCDD in the tissue, were significantly increased by dioxin exposure, suggesting that dioxin-activated AhR induces gene expression in LC and ICjM neurons.	Dioxins	184-190	aryl-hydrocarbon receptor	Mus musculus	201-204
33963922-11	2021	Thus, the neurotoxicological significance of the dioxin-activated AhR in the LC and ICjM warrants further studies.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	66-69
33866778-1	2021	Background: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.	Dioxins	39-46	aryl hydrocarbon receptor	Homo sapiens	89-114
33866778-1	2021	Background: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.	Dioxins	39-46	aryl hydrocarbon receptor	Homo sapiens	116-119
33866778-1	2021	Background: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	89-114
33866778-1	2021	Background: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	116-119
33866778-8	2021	Conclusion: These findings support a large body of epidemiologic evidence that exposure to AhR transactivating substances, such as dioxins and dioxin-like chemicals, might be involved in the pathogenesis of MetS and diabetes development.	Dioxins	131-138	aryl hydrocarbon receptor	Homo sapiens	91-94
33866778-8	2021	Conclusion: These findings support a large body of epidemiologic evidence that exposure to AhR transactivating substances, such as dioxins and dioxin-like chemicals, might be involved in the pathogenesis of MetS and diabetes development.	Dioxins	131-137	aryl hydrocarbon receptor	Homo sapiens	91-94
33513480-1	2021	In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien Hue, Vietnam.	Dioxins	118-125	aryl hydrocarbon receptor	Homo sapiens	18-21
33513480-1	2021	In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien Hue, Vietnam.	Dioxins	118-124	aryl hydrocarbon receptor	Homo sapiens	18-21
33865132-0	2021	Decreased serum testosterone levels associated with 17beta-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam.	Dioxins	127-133	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	52-87
33486542-1	2021	Electric arc furnaces (EAFs) in steelmaking plants are a major source of dioxins.	Dioxins	73-80	activity regulated cytoskeleton associated protein	Homo sapiens	9-12
33476717-8	2021	Altogether, the present findings substantiate that AhR-mediated responses of CPs technical mixtures in the DR-CALUX bioassay are caused by impurities, most likely some intermediate stable AhR-agonists such as dioxin-like PCNs or (chlorinated) PAHs.	Dioxins	209-215	aryl hydrocarbon receptor	Homo sapiens	51-54
33865132-12	2021	These results indicated that dioxin delayed the expression of the testosterone level and 17beta-HSD activity with growth in the 7-year-old boys.	Dioxins	29-35	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	89-99
33723743-1	2022	The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of downstream phase I enzyme-related genes by binding the cis element of dioxin-responsive elements (DREs)/xenobiotic-responsive elements.	Dioxins	223-229	aryl-hydrocarbon receptor	Mus musculus	4-29
33723743-1	2022	The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of downstream phase I enzyme-related genes by binding the cis element of dioxin-responsive elements (DREs)/xenobiotic-responsive elements.	Dioxins	223-229	aryl-hydrocarbon receptor	Mus musculus	31-34
33408340-1	2021	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	4-29
33660728-6	2021	Great progress has been achieved in identifying the species-specific sensitivity to dioxin-like compounds, which is attributed to different amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor.	Dioxins	84-90	aryl hydrocarbon receptor	Homo sapiens	196-221
33408340-1	2021	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	31-34
33297084-4	2021	In this study, we set out to determine human-relevant congener-specific potency values for a range of brominated and chlorinated dioxin congeners, based on their aryl hydrocarbon receptor (AhR)-mediated mode of toxic action.	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	162-187
32706914-3	2021	Dioxin acts in humans through an intracellular receptor, the aryl hydrocarbon receptor (AhR), which causes gene encoding of the enzyme cytochrome P450 1A1(CYP1A1).	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	61-86
32706914-3	2021	Dioxin acts in humans through an intracellular receptor, the aryl hydrocarbon receptor (AhR), which causes gene encoding of the enzyme cytochrome P450 1A1(CYP1A1).	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	88-91
32706914-3	2021	Dioxin acts in humans through an intracellular receptor, the aryl hydrocarbon receptor (AhR), which causes gene encoding of the enzyme cytochrome P450 1A1(CYP1A1).	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	135-154
32706914-3	2021	Dioxin acts in humans through an intracellular receptor, the aryl hydrocarbon receptor (AhR), which causes gene encoding of the enzyme cytochrome P450 1A1(CYP1A1).	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
33207481-0	2021	Spatial aspects of the dioxin risk formation in the Baltic Sea: A systematic review.	Dioxins	23-29	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	59-62
33207481-1	2021	Dioxins have been an inconvenience to the Baltic Sea ecosystem for decades.	Dioxins	0-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	49-52
33207481-4	2021	This paper presents a systematic literature review and knowledge synthesis about the regional dioxin risk formation in four sub-areas of the Baltic Sea and evaluates, whether systemic approach changes our thinking about the risk and its effective management.	Dioxins	94-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	148-151
33207481-5	2021	We studied the dioxin flux from atmospheric deposition to the Baltic Sea food webs, accumulation to two commercially and culturally important fish species, Baltic herring (Clupea harengus membras) and Baltic salmon (Salmo salar), and further to risk group members of four Baltic countries.	Dioxins	15-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	69-72
33207481-8	2021	In the southern Baltic Sea, atmospheric pollution levels are relatively high and environmental processes to decrease bioavailability of dioxins unfavorable, but the growth is fast, which curb the bioaccumulation of dioxins in the biota.	Dioxins	136-143	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
33207481-8	2021	In the southern Baltic Sea, atmospheric pollution levels are relatively high and environmental processes to decrease bioavailability of dioxins unfavorable, but the growth is fast, which curb the bioaccumulation of dioxins in the biota.	Dioxins	215-222	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
33316272-0	2021	Non-dioxin-like polychlorinated biphenyl 19 has distinct effects on human Kv1.3 and Kv1.5 channels.	Dioxins	4-10	potassium voltage-gated channel subfamily A member 3	Homo sapiens	74-79
33316272-0	2021	Non-dioxin-like polychlorinated biphenyl 19 has distinct effects on human Kv1.3 and Kv1.5 channels.	Dioxins	4-10	potassium voltage-gated channel subfamily A member 5	Homo sapiens	84-89
33445793-4	2021	Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	33-58
33445793-4	2021	Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	60-63
33445793-5	2021	In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards.	Dioxins	72-78	aryl hydrocarbon receptor	Homo sapiens	65-68
33297084-4	2021	In this study, we set out to determine human-relevant congener-specific potency values for a range of brominated and chlorinated dioxin congeners, based on their aryl hydrocarbon receptor (AhR)-mediated mode of toxic action.	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	189-192
33297084-5	2021	Transactivation of the AhR was measured using dioxin-responsive (DR) CALUX reporter gene assays.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	23-26
33374508-0	2020	The Aryl Hydrocarbon Receptor in Energy Balance: The Road from Dioxin-Induced Wasting Syndrome to Combating Obesity with Ahr Ligands.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	4-29
33079390-4	2021	Oxidative stress response (AREc32) may become activated by various stressors covering a broad range of physico-chemical properties and aryl hydrocarbon receptor induction (AhR-CALUX) by hydrophobic compounds such as dioxins and dioxin-like molecules.	Dioxins	216-223	aryl hydrocarbon receptor	Homo sapiens	135-160
33079390-4	2021	Oxidative stress response (AREc32) may become activated by various stressors covering a broad range of physico-chemical properties and aryl hydrocarbon receptor induction (AhR-CALUX) by hydrophobic compounds such as dioxins and dioxin-like molecules.	Dioxins	216-223	aryl hydrocarbon receptor	Homo sapiens	172-175
33079390-4	2021	Oxidative stress response (AREc32) may become activated by various stressors covering a broad range of physico-chemical properties and aryl hydrocarbon receptor induction (AhR-CALUX) by hydrophobic compounds such as dioxins and dioxin-like molecules.	Dioxins	216-222	aryl hydrocarbon receptor	Homo sapiens	135-160
33079390-4	2021	Oxidative stress response (AREc32) may become activated by various stressors covering a broad range of physico-chemical properties and aryl hydrocarbon receptor induction (AhR-CALUX) by hydrophobic compounds such as dioxins and dioxin-like molecules.	Dioxins	216-222	aryl hydrocarbon receptor	Homo sapiens	172-175
33320884-1	2020	Activation of the aryl hydrocarbon receptor (AHR) by the environmental toxin dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) causes diverse toxicities, including thymus atrophy and hepatosteatosis.	Dioxins	77-83	aryl hydrocarbon receptor	Homo sapiens	18-43
33320884-1	2020	Activation of the aryl hydrocarbon receptor (AHR) by the environmental toxin dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) causes diverse toxicities, including thymus atrophy and hepatosteatosis.	Dioxins	77-83	aryl hydrocarbon receptor	Homo sapiens	45-48
33349622-2	2020	The aryl hydrocarbon receptor (AhR) was discovered as a dioxin-binding transcription factor involved in the metabolism of different environmental toxicants in vertebrates.	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	31-34
33278027-2	2021	Dioxin is an emerging environmental AChE disruptor and is a typical persistent organic pollutant with multiple toxic effects on the nervous system.	Dioxins	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
33278027-3	2021	Growing evidence has shown that there is a significant link between dioxin exposure and neurodegenerative diseases and neurodevelopmental disorders, most of which involve AChE and cholinergic dysfunctions.	Dioxins	68-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
33278027-4	2021	Therefore, an in-depth understanding of the effects of dioxin on AChE and the related mechanisms of action might help to shed light on the molecular bases of dioxin impacts on the nervous system.	Dioxins	55-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
33027880-6	2020	Subsequently, we revealed that MEHP recruited AhR to dioxin response element (DRE) sequences and decreased TCDD-induced AhR-DRE binding in CYP1A1 genes.	Dioxins	53-59	aryl hydrocarbon receptor	Homo sapiens	46-49
33278027-4	2021	Therefore, an in-depth understanding of the effects of dioxin on AChE and the related mechanisms of action might help to shed light on the molecular bases of dioxin impacts on the nervous system.	Dioxins	158-164	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
33278027-5	2021	In the past decade, the effects of dioxins on AChE have been revealed in cultured cells of different origins and in rodent animal models.	Dioxins	35-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
33278027-6	2021	Unlike OP and carbamate pesticides, dioxin-induced AChE disturbance is not due to direct inhibition of enzymatic activity; instead, dioxin causes alterations of AChE expression in certain models.	Dioxins	36-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
33278027-7	2021	As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation.	Dioxins	40-46	aryl hydrocarbon receptor	Homo sapiens	60-85
33278027-7	2021	As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation.	Dioxins	40-46	aryl hydrocarbon receptor	Homo sapiens	87-90
33278027-7	2021	As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation.	Dioxins	179-185	aryl hydrocarbon receptor	Homo sapiens	60-85
33278027-7	2021	As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation.	Dioxins	179-185	aryl hydrocarbon receptor	Homo sapiens	87-90
33278027-7	2021	As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation.	Dioxins	179-185	acetylcholinesterase (Cartwright blood group)	Homo sapiens	194-198
33278027-8	2021	In this mini-review, the effects of dioxin on AChE and the diverse roles of the AhR pathway in AChE regulation are summarized.	Dioxins	36-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
33278027-8	2021	In this mini-review, the effects of dioxin on AChE and the diverse roles of the AhR pathway in AChE regulation are summarized.	Dioxins	36-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
32712422-1	2020	Dioxins, a group of persistent organic pollutants, have been proved to correlate with ranges of diseases by activating the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	123-148
32535446-5	2020	RESULTS: PCB concentrations (mainly non-dioxin-like (ndl)-PCBs) were higher than OCP ones.	Dioxins	40-46	pyruvate carboxylase	Homo sapiens	9-12
32535446-8	2020	Among the dioxin-like (dl)-PCBs, non-ortho PCB 169, 77 and 126 were assessed in some milk samples; in all areas we detected the mono-ortho PCB 118 and PCB 105.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	27-30
32554009-3	2020	Seven luciferase reporter gene cell lines were used i.e. three (human and rat) responsive to dioxins through the aryl hydrocarbon receptor (AhR) and four (human) responsive to steroids through the estrogen (ER), androgen (AR), progesterone (PR), and glucocorticoid (GR) receptors.	Dioxins	93-100	aryl hydrocarbon receptor	Rattus norvegicus	140-143
33113971-2	2020	The mechanism of dioxin action requires an aryl hydrocarbon receptor (AhR), but the downstream mechanisms are not yet precisely clear.	Dioxins	17-23	aryl hydrocarbon receptor	Homo sapiens	43-68
33113971-2	2020	The mechanism of dioxin action requires an aryl hydrocarbon receptor (AhR), but the downstream mechanisms are not yet precisely clear.	Dioxins	17-23	aryl hydrocarbon receptor	Homo sapiens	70-73
33113971-8	2020	Intriguingly, the dioxin-responsive element (DRE), the binding site of AhR, was not overrepresented as much as other cis-elements were.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	71-74
33113971-9	2020	Bioinformatics analysis of the AhR binding profile unveils potential cooperation of AhR with E2F2, CTCFL, and ZBT14 TFs in the dioxin response.	Dioxins	127-133	aryl hydrocarbon receptor	Homo sapiens	31-34
33113971-9	2020	Bioinformatics analysis of the AhR binding profile unveils potential cooperation of AhR with E2F2, CTCFL, and ZBT14 TFs in the dioxin response.	Dioxins	127-133	aryl hydrocarbon receptor	Homo sapiens	84-87
33113971-9	2020	Bioinformatics analysis of the AhR binding profile unveils potential cooperation of AhR with E2F2, CTCFL, and ZBT14 TFs in the dioxin response.	Dioxins	127-133	E2F transcription factor 2	Homo sapiens	93-97
33113971-9	2020	Bioinformatics analysis of the AhR binding profile unveils potential cooperation of AhR with E2F2, CTCFL, and ZBT14 TFs in the dioxin response.	Dioxins	127-133	CCCTC-binding factor like	Homo sapiens	99-104
33105907-1	2020	Aryl hydrocarbon receptor (AhR) was identified in the early 1970s as a receptor for the ubiquitous environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), which is a member of halogenated aromatic hydrocarbons (HAHs).	Dioxins	154-160	aryl hydrocarbon receptor	Homo sapiens	0-25
33105907-1	2020	Aryl hydrocarbon receptor (AhR) was identified in the early 1970s as a receptor for the ubiquitous environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), which is a member of halogenated aromatic hydrocarbons (HAHs).	Dioxins	154-160	aryl hydrocarbon receptor	Homo sapiens	27-30
33066667-3	2020	AhR, when binding with exogenous ligands (environmental pollutants such as polycylic aryl hydrocarbon (PAH), dioxins) or endogenous ligand indoxyl-sulfate (IS), has dual functions that are mediated by the nature of the binding ligand, binding time, and specific pathways of distinct ligands.	Dioxins	109-116	aryl hydrocarbon receptor	Homo sapiens	0-3
32712422-1	2020	Dioxins, a group of persistent organic pollutants, have been proved to correlate with ranges of diseases by activating the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	150-153
32712422-2	2020	However, previous dioxin toxicity studies primarily focused on the activation of AhR with signaling pathways at gene and protein levels.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	81-84
32563159-1	2020	The activation of the aryl hydrocarbon receptor (AHR) occurs through the binding of dioxin-like compounds (DLCs) or natural ligands.	Dioxins	84-90	aryl hydrocarbon receptor 1 alpha	Gallus gallus	22-47
32563159-1	2020	The activation of the aryl hydrocarbon receptor (AHR) occurs through the binding of dioxin-like compounds (DLCs) or natural ligands.	Dioxins	84-90	aryl hydrocarbon receptor 1 alpha	Gallus gallus	49-52
32932962-1	2020	The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs).	Dioxins	160-166	aryl hydrocarbon receptor	Homo sapiens	4-29
32932962-1	2020	The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs).	Dioxins	160-166	aryl hydrocarbon receptor	Homo sapiens	31-34
32932962-1	2020	The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs).	Dioxins	174-180	aryl hydrocarbon receptor	Homo sapiens	4-29
32932962-1	2020	The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs).	Dioxins	174-180	aryl hydrocarbon receptor	Homo sapiens	31-34
32730300-1	2020	Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	0-25
32784381-1	2020	Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydrocarbon receptor (AHR) in immunomodulation has been the focus of considerable research interest.	Dioxins	74-80	aryl hydrocarbon receptor	Homo sapiens	139-164
32535108-1	2020	Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of physiologic AHR functions.	Dioxins	68-74	aryl hydrocarbon receptor	Homo sapiens	0-25
32535108-1	2020	Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of physiologic AHR functions.	Dioxins	68-74	aryl hydrocarbon receptor	Homo sapiens	27-30
32569627-0	2020	Gestational dioxin exposure suppresses prolactin-stimulated nursing in lactating dam rats to impair development of postnatal offspring.	Dioxins	12-18	prolactin	Rattus norvegicus	39-48
32569627-6	2020	Intracerebroventricular infusion of prolactin to dioxin-exposed dams restored or tended to restore many of the above defects observed both in mothers and offspring.	Dioxins	49-55	prolactin	Rattus norvegicus	36-45
32569627-10	2020	These results provide novel evidence that gestational dioxin exposure attenuates prolactin-stimulated nursing in lactating dams to impair offspring development, and that immaturity of prolactin-producing cells can contribute to them.	Dioxins	54-60	prolactin	Rattus norvegicus	81-90
32388262-6	2020	The mean dioxin-like PCB and polychlorinated naphthalene TEQs were ~8.9 and ~6.6 times higher in stack gases from a SCu equipped with an oxygen-enriched smelting furnace than in stack gases from a SCu with a converter furnace.	Dioxins	9-15	pyruvate carboxylase	Homo sapiens	21-24
32289173-3	2020	After binding to ligands, such as dioxin, AhR translocates from the cytoplasm to the nucleus with a molecular chaperone complex.	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	42-45
32730300-1	2020	Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	27-30
32597352-1	2020	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and structurally related halogenated aromatics modulate gene expression and induce biochemical and toxic responses that are mediated by initial binding to the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	210-235
32908870-2	2020	Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR).	Dioxins	11-17	aryl hydrocarbon receptor	Homo sapiens	42-67
32908870-2	2020	Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR).	Dioxins	11-17	aryl hydrocarbon receptor	Homo sapiens	69-72
32678826-6	2020	Mechanistically, activated AHR binds to HTLV-1 LTR dioxin response element (DRE) site (CACGCATAT) and drives plus-strand transcription.	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	27-30
32464404-9	2020	Our results strongly demonstrate that these novel indole-benzimidazoles can modulate ER target gene expression as well as dioxin-mediated aryl hydrocarbon receptor and amino acid deprivation-mediated integrated stress response signaling in a dose-dependent manner.	Dioxins	122-128	aryl hydrocarbon receptor	Homo sapiens	138-163
32597352-1	2020	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and structurally related halogenated aromatics modulate gene expression and induce biochemical and toxic responses that are mediated by initial binding to the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	237-240
32043632-0	2020	Overexpression of the aryl hydrocarbon receptor in frontal fibrosing alopecia and lichen planopilaris: a potential pathogenic role for dioxins?- an investigational study of 38 patients.	Dioxins	135-142	aryl hydrocarbon receptor	Homo sapiens	22-47
32831531-2	2020	Based on their ability to activate the aryl hydrocarbon receptor (AhR), PCBs are subdivided into two classes: dioxin-like (DL) and non-dioxin-like (NDL) PCBs.	Dioxins	110-116	aryl-hydrocarbon receptor	Mus musculus	39-64
32199159-0	2020	Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results.	Dioxins	39-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	6-12
32036309-0	2020	Generation and application of a Tg(cyp1a:egfp) transgenic marine medaka (Oryzias melastigma) line as an in vivo assay to sensitively detect dioxin-like compounds in the environment.	Dioxins	140-146	cytochrome P450 1A1	Oryzias latipes	35-40
32213394-4	2020	For AhR binding, the offset or edge-on pi-pi stackings with aromatic motifs including Phe289, Phe345 and His285 were shown to be structurally required whereas the electrostatic attraction validated for AhR binding to dioxins might be less effective for 2,2",3,4,4"-pentabromodiphenyl ether (BDE-85).	Dioxins	217-224	aryl hydrocarbon receptor	Homo sapiens	4-7
32213394-4	2020	For AhR binding, the offset or edge-on pi-pi stackings with aromatic motifs including Phe289, Phe345 and His285 were shown to be structurally required whereas the electrostatic attraction validated for AhR binding to dioxins might be less effective for 2,2",3,4,4"-pentabromodiphenyl ether (BDE-85).	Dioxins	217-224	aryl hydrocarbon receptor	Homo sapiens	202-205
32105967-0	2020	Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.	Dioxins	37-43	pyruvate carboxylase	Mus musculus	49-52
32283119-2	2020	The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl hydrocarbon receptor (AhR) pathway can be activated by dioxins.	Dioxins	177-184	aryl-hydrocarbon receptor	Mus musculus	117-142
32283119-2	2020	The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl hydrocarbon receptor (AhR) pathway can be activated by dioxins.	Dioxins	177-184	aryl-hydrocarbon receptor	Mus musculus	144-147
32283119-8	2020	In addition, dioxin inhibited Oct4 expression, and preliminary data suggest that hypermethylation of the Oct4 promoter may be a putative mechanism, suggesting that TCDD might induce cleft palate by inhibiting the proliferation of palatal mesenchymal cells mediated by Oct4.	Dioxins	13-19	POU domain, class 5, transcription factor 1	Mus musculus	30-34
32481506-4	2020	Epidemiological studies show a statistical link between exposure to pesticides, polychlorinated bisphenyls, bisphenol A, phthalates, aromatic polycyclic hydrocarbides, or dioxins and insulin resistance.	Dioxins	171-178	insulin	Homo sapiens	183-190
32199159-2	2020	Many lower chlorinated and non-dioxin-like PCBs have been observed to be mutagenic following activation by human CYP2E1, while activation of dioxin-like (DL-) PCBs by this enzyme has never been evidenced.	Dioxins	31-37	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	113-119
32522345-2	2020	Activated AhR binds to dioxin responsive elements (DRE) and initiates transcription of target genes, including the gene encoding prostaglandin endoperoxide synthase 2 (PTGS-2), which is also activated by the transcription factor NF-kB.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	10-13
32522345-2	2020	Activated AhR binds to dioxin responsive elements (DRE) and initiates transcription of target genes, including the gene encoding prostaglandin endoperoxide synthase 2 (PTGS-2), which is also activated by the transcription factor NF-kB.	Dioxins	23-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-166
32522345-2	2020	Activated AhR binds to dioxin responsive elements (DRE) and initiates transcription of target genes, including the gene encoding prostaglandin endoperoxide synthase 2 (PTGS-2), which is also activated by the transcription factor NF-kB.	Dioxins	23-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-174
31878777-1	2020	Dioxins, mostly through activation of aryl hydrocarbon receptor (AhR), are potent toxic substances widely distributed in the environment, while moderated suppression of AhR also exhibits anti-tumor effects.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	38-63
32041038-1	2020	Aryl hydrocarbon receptor (AhR) plays important roles in the interferences of dioxin exposure with the occurrence and development of tumors.	Dioxins	78-84	aryl hydrocarbon receptor	Homo sapiens	0-25
32041038-1	2020	Aryl hydrocarbon receptor (AhR) plays important roles in the interferences of dioxin exposure with the occurrence and development of tumors.	Dioxins	78-84	aryl hydrocarbon receptor	Homo sapiens	27-30
32041038-11	2020	Thus, we proposed that AhR-mediated up-regulation of pro-adhesive genes might be involved in the inhibitory effects of dioxin on the spontaneous movement of neuroblastoma cells.	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	23-26
32036522-0	2020	Assessment of PCDD/F and dioxin-like PCB levels in environmental and food samples in the vicinity of IZAYDAS waste incinerator plant (WIP): from past to present.	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	37-40
31784153-7	2020	In urban site, PCB-52 and dioxin like PCBs (dl-PCBs) have increased from the past observations with maximum PCB-52 concentration in night time samples.	Dioxins	26-32	pyruvate carboxylase	Homo sapiens	38-41
31608602-0	2020	Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.	Dioxins	108-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19
31805342-0	2020	Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction.	Dioxins	42-48	aryl hydrocarbon receptor repressor	Homo sapiens	10-14
31805342-0	2020	Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction.	Dioxins	42-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-65
31805342-1	2020	The current study uses the metabolic probe, antipyrine, and AhRR transcript expression (qRT-PCR) to examine the impact of the AhRR (565C > G or Pro185Ala, rs2292596) genetic polymorphism upon CYP1A2 inducibility in an established cohort of male firefighters with exposure to dioxin-like chemicals.	Dioxins	275-281	aryl hydrocarbon receptor repressor	Homo sapiens	126-130
31805342-4	2020	The induction of CYP1A2 was dioxin-dependent among carriers of the G allele.	Dioxins	28-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
31805342-5	2020	Multivariate models indicated that CYP1A2 activity, detected as urinary 3-hydroxymethylantipyrine, was significantly correlated with cotinine concentration and for those currently working as firefighters, dioxin body burden (beta = 0.54, p = 0.041).	Dioxins	205-211	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	35-41
31805342-7	2020	Our study of firefighters using the induction of CYP1A2 as an indicator suggest that G allele proteins have variable AhR repressor activity which is manifested in a dioxin-dependent manner.	Dioxins	165-171	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	49-55
31805342-7	2020	Our study of firefighters using the induction of CYP1A2 as an indicator suggest that G allele proteins have variable AhR repressor activity which is manifested in a dioxin-dependent manner.	Dioxins	165-171	aryl hydrocarbon receptor repressor	Homo sapiens	117-130
31878777-1	2020	Dioxins, mostly through activation of aryl hydrocarbon receptor (AhR), are potent toxic substances widely distributed in the environment, while moderated suppression of AhR also exhibits anti-tumor effects.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	65-68
31878777-1	2020	Dioxins, mostly through activation of aryl hydrocarbon receptor (AhR), are potent toxic substances widely distributed in the environment, while moderated suppression of AhR also exhibits anti-tumor effects.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	169-172
31996693-8	2020	Our results show that a single exposure to dioxin can suppress basal insulin levels long-term in both sexes, but effects on glucose homeostasis are sex-dependent.	Dioxins	43-49	insulin	Homo sapiens	69-76
31841312-0	2020	An assessment of risks of dioxins for aryl hydrocarbon receptor-mediated effects in polar bear (Ursus maritimus) by in vitro and in silico approaches.	Dioxins	26-33	aryl hydrocarbon receptor	Ursus maritimus	38-63
31465602-7	2020	In cultured sebocytes exposed to SMFE (i) transcriptomic analysis showed an up-regulation by a factor of 15 of RNA coding for K75 and (ii) the gene expression and catalytic activity of CYP1A1 under exposure to dioxin was decreased.	Dioxins	210-216	keratin 75	Homo sapiens	126-129
31465602-7	2020	In cultured sebocytes exposed to SMFE (i) transcriptomic analysis showed an up-regulation by a factor of 15 of RNA coding for K75 and (ii) the gene expression and catalytic activity of CYP1A1 under exposure to dioxin was decreased.	Dioxins	210-216	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	185-191
31733235-0	2020	Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells.	Dioxins	39-45	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	6-12
31733235-2	2020	It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3",4,4",5-pentachlorobiphenyl (PCB 126) and 3,3",4,4"-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the metabolism of dioxin-like (DL) PCBs remain unconfirmed.	Dioxins	217-223	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31
31733235-2	2020	It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3",4,4",5-pentachlorobiphenyl (PCB 126) and 3,3",4,4"-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the metabolism of dioxin-like (DL) PCBs remain unconfirmed.	Dioxins	217-223	pyruvate carboxylase	Homo sapiens	99-102
31733235-2	2020	It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3",4,4",5-pentachlorobiphenyl (PCB 126) and 3,3",4,4"-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the metabolism of dioxin-like (DL) PCBs remain unconfirmed.	Dioxins	217-223	pyruvate carboxylase	Homo sapiens	143-146
31738530-7	2019	Results of the two bioassays showed that most of the tested PHCZs could pose dioxin-like AhR agonist effects, change the expression levels of AhR downstream genes, and interact with AhR in accordance with TCDD.	Dioxins	77-83	aryl hydrocarbon receptor	Homo sapiens	89-92
31734582-6	2020	Since the circadian regulation of metabolism is particularly well understood, and dioxin and dioxin-like compounds are of major concern for environmental health we focused on the ubiquitous drug metabolizing detoxification system mediated by the aryl hydrocarbon receptor (AHR).	Dioxins	82-88	aryl hydrocarbon receptor	Homo sapiens	246-271
31734582-6	2020	Since the circadian regulation of metabolism is particularly well understood, and dioxin and dioxin-like compounds are of major concern for environmental health we focused on the ubiquitous drug metabolizing detoxification system mediated by the aryl hydrocarbon receptor (AHR).	Dioxins	93-99	aryl hydrocarbon receptor	Homo sapiens	246-271
31775093-2	2020	Generally, dioxin exerts its neurotoxicity via aryl hydrocarbon receptor (AhR).	Dioxins	11-17	aryl hydrocarbon receptor	Rattus norvegicus	47-72
31775093-2	2020	Generally, dioxin exerts its neurotoxicity via aryl hydrocarbon receptor (AhR).	Dioxins	11-17	aryl hydrocarbon receptor	Rattus norvegicus	74-77
31775093-4	2020	However, the effects of dioxin on NFL expression and involved mechanisms are incompletely understood.	Dioxins	24-30	neurofilament light chain	Rattus norvegicus	34-37
32800270-16	2020	CONCLUSION: This research identified the importance of AHRR in dioxin response and demonstrated an example of genetic and environmental interaction, indispensable in the development of many complex diseases.	Dioxins	63-69	aryl hydrocarbon receptor repressor	Homo sapiens	55-59
31816860-5	2019	Ligation of AHR by dioxins induces exaggerated acceleration of epidermal terminal differentiation (keratinization) and converts sebocytes toward keratinocyte differentiation, which results in chloracne formation.	Dioxins	19-26	aryl hydrocarbon receptor	Homo sapiens	12-15
31599008-3	2019	The present study aimed at evaluating the effects of dioxin on CatSper2 gene and protein expression, testicular histopathology, sperm quality and biochemical parameters in a mice model.	Dioxins	53-59	cation channel, sperm associated 2	Mus musculus	63-71
31599008-7	2019	Administration of dioxin significantly downregulated the CatSper2 gene and protein expression.	Dioxins	18-24	cation channel, sperm associated 2	Mus musculus	57-65
31671369-0	2019	Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish.	Dioxins	43-49	aryl hydrocarbon receptor 1a	Danio rerio	14-39
31563530-0	2019	Dioxin-like (DL-) polychlorinated biphenyls induced immunotoxicity through apoptosis in mice splenocytes via the AhR mediated mitochondria dependent signaling pathways.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	113-116
31671369-8	2019	It is intriguing that CH223191 successfully abolished the holistic effects of dioxin on gut microbiota, which inferred that growth of gut microbes was directly controlled by AhR activation without the involvement of host feedback modulation.	Dioxins	78-84	aryl hydrocarbon receptor 1a	Danio rerio	174-177
31154221-6	2019	Dioxin-like PCBs accounted for 11.0-70.3% and 2.31-54.8% of total PCB residues in soil and air, respectively.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	12-15
31638212-1	2019	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally isolated and characterized as the dioxin or xenobiotic receptor.	Dioxins	124-130	aryl-hydrocarbon receptor	Mus musculus	4-29
31638212-1	2019	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally isolated and characterized as the dioxin or xenobiotic receptor.	Dioxins	124-130	aryl-hydrocarbon receptor	Mus musculus	31-34
31795255-4	2019	One transcription factor that is expressed in all cutaneous cells and activated by various environmental stressors, including dioxins, polycyclic aromatic hydrocarbons, and ultraviolet radiation, is the aryl hydrocarbon receptor (AHR).	Dioxins	126-133	aryl hydrocarbon receptor	Homo sapiens	203-228
31795255-4	2019	One transcription factor that is expressed in all cutaneous cells and activated by various environmental stressors, including dioxins, polycyclic aromatic hydrocarbons, and ultraviolet radiation, is the aryl hydrocarbon receptor (AHR).	Dioxins	126-133	aryl hydrocarbon receptor	Homo sapiens	230-233
31598705-7	2019	Star-PAP control of the distal-specific isoform is stimulated by oxidative stress and the toxin dioxin.	Dioxins	96-102	terminal uridylyl transferase 1, U6 snRNA-specific	Homo sapiens	0-8
31552475-1	2019	Prediction of pEC50 values of dioxins binding with the aryl hydrocarbon receptor (AhR) is of great significance for exploring how dioxins induce toxicity in human body and evaluating their environmental behaviors and risks.	Dioxins	30-37	aryl hydrocarbon receptor	Homo sapiens	55-80
31552475-1	2019	Prediction of pEC50 values of dioxins binding with the aryl hydrocarbon receptor (AhR) is of great significance for exploring how dioxins induce toxicity in human body and evaluating their environmental behaviors and risks.	Dioxins	30-37	aryl hydrocarbon receptor	Homo sapiens	82-85
31552475-1	2019	Prediction of pEC50 values of dioxins binding with the aryl hydrocarbon receptor (AhR) is of great significance for exploring how dioxins induce toxicity in human body and evaluating their environmental behaviors and risks.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	55-80
31552475-1	2019	Prediction of pEC50 values of dioxins binding with the aryl hydrocarbon receptor (AhR) is of great significance for exploring how dioxins induce toxicity in human body and evaluating their environmental behaviors and risks.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	82-85
31552475-8	2019	Importantly, the ability of dioxins binding to AhR is mainly determined by molecular descriptors including E1m, SM09_AEA (dm), RDF065u, F05 [Cl-Cl], and Neoplastic-80.	Dioxins	28-35	aryl hydrocarbon receptor	Homo sapiens	47-50
31465774-1	2019	Aryl hydrocarbon receptor (AHR), identified in studies of dioxin toxicity, has been characterized as ligand-activated transcription factor involved in diverse functions including microbial defense, cell proliferation, immunity and NAD metabolism.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	0-25
31465774-1	2019	Aryl hydrocarbon receptor (AHR), identified in studies of dioxin toxicity, has been characterized as ligand-activated transcription factor involved in diverse functions including microbial defense, cell proliferation, immunity and NAD metabolism.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	27-30
31683543-1	2019	The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts.	Dioxins	185-192	aryl hydrocarbon receptor	Homo sapiens	4-29
31683543-1	2019	The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts.	Dioxins	185-192	aryl hydrocarbon receptor	Homo sapiens	31-34
31683543-1	2019	The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts.	Dioxins	185-192	aryl hydrocarbon receptor	Homo sapiens	36-39
31683543-1	2019	The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts.	Dioxins	185-192	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	62-66
31665024-7	2019	However, the TEAD3 gene had four different CpG sites that showed loss of DNA methylation associated with dioxin exposure.	Dioxins	105-111	TEA domain transcription factor 3	Homo sapiens	13-18
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Dioxins	209-215	aryl hydrocarbon receptor	Rattus norvegicus	101-126
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Dioxins	209-215	aryl hydrocarbon receptor	Rattus norvegicus	128-131
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Dioxins	200-206	aryl hydrocarbon receptor	Homo sapiens	27-30
31552251-1	2019	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that responds to a wide range of chemicals, including chemical carcinogens such as dioxins and carcinogenic polyaromatic hydrocarbons, and induces a battery of genes associated with detoxification, proliferation, and immune regulation.	Dioxins	162-169	aryl hydrocarbon receptor	Sus scrofa	4-29
31552251-1	2019	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that responds to a wide range of chemicals, including chemical carcinogens such as dioxins and carcinogenic polyaromatic hydrocarbons, and induces a battery of genes associated with detoxification, proliferation, and immune regulation.	Dioxins	162-169	aryl hydrocarbon receptor	Sus scrofa	31-34
31093659-7	2019	Promoter analysis revealed that the IL-33 promoter has 2 dioxin response elements (DREs).	Dioxins	57-63	interleukin 33	Mus musculus	36-41
30993357-4	2019	In addition, PCB 126 and PCB 169 were found to be the major toxicity contributors of dioxin-like PCBs in the YRDNR, which should require special focus.	Dioxins	85-91	pyruvate carboxylase	Homo sapiens	13-16
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Dioxins	200-206	aryl hydrocarbon receptor	Homo sapiens	0-25
31200452-0	2019	Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells.	Dioxins	47-53	pyruvate carboxylase	Homo sapiens	59-62
31200452-3	2019	The PBMCs of a healthy volunteer (male, 56 years old) were exposed to a mixture of dioxin-like (DL)-PCBs (PCB 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, and 189, 250 microg/L resp.) or non-dioxin-like (NDL)-PCBs (PCB 28, 52, 101, 138, 153, 180, 250 microg/L resp.) or single PCB congener (no.28, 138, 153, 180, 250 microg/L resp.).	Dioxins	83-89	pyruvate carboxylase	Homo sapiens	100-103
30993357-4	2019	In addition, PCB 126 and PCB 169 were found to be the major toxicity contributors of dioxin-like PCBs in the YRDNR, which should require special focus.	Dioxins	85-91	pyruvate carboxylase	Homo sapiens	25-28
30933768-8	2019	On the other hand, PCDD/F and dioxin-like PCB levels in soil in rural areas, without a contamination source, are normally safe for food producing animals housed outdoors resulting in healthy food (e.g. meat, eggs, milk).	Dioxins	30-36	pyruvate carboxylase	Homo sapiens	42-45
30506768-2	2019	The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR).	Dioxins	17-24	aryl hydrocarbon receptor	Homo sapiens	45-70
30506768-2	2019	The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR).	Dioxins	17-24	aryl hydrocarbon receptor	Homo sapiens	72-75
30506768-2	2019	The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR).	Dioxins	17-24	aryl hydrocarbon receptor repressor	Homo sapiens	104-108
30953668-2	2019	The aryl hydrocarbon receptor (AhR) is a ligand- activated transcription factor known primarily as the mediator of dioxin toxicity.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	4-29
30953668-2	2019	The aryl hydrocarbon receptor (AhR) is a ligand- activated transcription factor known primarily as the mediator of dioxin toxicity.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	31-34
31127949-6	2019	A threshold of AhR activation was identified in rat liver that separated a meaningful "tumorigenic-strength AhR signal" from a statistically-significant AhR activation signal that was not associated with dioxin-like carcinogenicity.	Dioxins	204-210	aryl hydrocarbon receptor	Rattus norvegicus	15-18
31127949-8	2019	A sustained activation of AhR above the threshold could thus be used in early pharmaceutical development to identify dose levels of drug candidates expected to exhibit dioxin-like carcinogenic potential.	Dioxins	168-174	aryl hydrocarbon receptor	Rattus norvegicus	26-29
31096425-11	2019	Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments.	Dioxins	57-64	cytochrome P450, family 1, subfamily A	Danio rerio	77-82
30768972-8	2019	Since dioxin-like PCBs may elicit inflammatory cascades through multiple mechanisms, we then pretreated macrophages with both aryl hydrocarbon receptor (AhR) and NF-kappaB antagonists prior to PCB treatment.	Dioxins	6-12	pyruvate carboxylase	Homo sapiens	18-21
30768972-10	2019	Our data demonstrate the involvement of PCB 126 in macrophage polarization and inflammation, indicating another important role of dioxin-like PCBs in the pathology of atherosclerosis.	Dioxins	130-136	pyruvate carboxylase	Homo sapiens	40-43
30557720-6	2019	Particularly, NO3 additions and their subsequent reactions yield dialdehydes (P16 and P17) and 2,8-DCDD, which is the first report of the generation of dioxin from atmospheric oxidation of p,p"-Dicofol.	Dioxins	152-158	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
30557720-6	2019	Particularly, NO3 additions and their subsequent reactions yield dialdehydes (P16 and P17) and 2,8-DCDD, which is the first report of the generation of dioxin from atmospheric oxidation of p,p"-Dicofol.	Dioxins	152-158	cyclin dependent kinase inhibitor 2A	Homo sapiens	78-81
30557720-6	2019	Particularly, NO3 additions and their subsequent reactions yield dialdehydes (P16 and P17) and 2,8-DCDD, which is the first report of the generation of dioxin from atmospheric oxidation of p,p"-Dicofol.	Dioxins	152-158	family with sequence similarity 72 member B	Homo sapiens	86-89
30640082-7	2019	Among the 11 genes, AHRR and CYP1A1 are involved in the aryl hydrocarbon receptor signaling pathway known to mediate dioxin toxicity.	Dioxins	117-123	aryl hydrocarbon receptor repressor	Homo sapiens	20-24
30640082-7	2019	Among the 11 genes, AHRR and CYP1A1 are involved in the aryl hydrocarbon receptor signaling pathway known to mediate dioxin toxicity.	Dioxins	117-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
30640082-7	2019	Among the 11 genes, AHRR and CYP1A1 are involved in the aryl hydrocarbon receptor signaling pathway known to mediate dioxin toxicity.	Dioxins	117-123	aryl hydrocarbon receptor	Homo sapiens	56-81
30641090-2	2019	Since the PGE2 receptor has four subtypes, EP1 - EP4, this study was aimed to challenge the hypothesis that at least one of the four subtypes is responsible for the pathogenesis of dioxin-induced hydronephrosis.	Dioxins	181-187	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	49-52
30813950-11	2019	Conversely, PFOA and dioxin-like PCB-167 were associated with 61% (95% CI 35% to 87%) and 22% (95% CI 8% to 35%) more propionic and acetic acid, respectively.	Dioxins	21-27	pyruvate carboxylase	Homo sapiens	33-36
30266049-8	2019	More importantly, our study demonstrates the toxicity of dioxin in human embryonic development and uncovered a novel mechanism by which dioxin and AHR regulates lineage commitment.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	147-150
30384297-10	2019	Even though treatment and dechlorination reduced the dioxin-like toxicity of the PCB mixture, this effect might be offset by the incomplete removal of dechlorination products.	Dioxins	53-59	pyruvate carboxylase	Homo sapiens	81-84
30346592-1	2019	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	129-154
30346592-1	2019	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	156-159
30316459-0	2019	Corrigendum to "Concentrations of dioxin-like PCB congeners in unweathered Aroclors by HRGC/HRMS using EPA Method 1668A" [Chemosphere 54 (2004) 79-87 with Erratum (Chemosphere 58 (2005) 1151)].	Dioxins	34-40	pyruvate carboxylase	Homo sapiens	46-49
30779909-1	2019	Diverse physiologic functions of AHR, a transcription factor discovered in studies of dioxin toxicity, are currently elucidated in many laboratories including chemical and microbial defense, immunity and myelopoiesis.	Dioxins	86-92	aryl hydrocarbon receptor	Homo sapiens	33-36
31035533-1	2019	The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma.	Dioxins	108-115	aryl-hydrocarbon receptor	Mus musculus	4-29
31035533-1	2019	The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma.	Dioxins	108-115	aryl-hydrocarbon receptor	Mus musculus	31-34
31035533-1	2019	The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma.	Dioxins	108-114	aryl-hydrocarbon receptor	Mus musculus	4-29
31035533-1	2019	The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma.	Dioxins	108-114	aryl-hydrocarbon receptor	Mus musculus	31-34
30703721-2	2019	The maintenance and function of ILC3s involve the activity of aryl hydrocarbon receptor (AhR), a potent ligand of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), one of the most toxic dioxin congeners.	Dioxins	152-158	aryl-hydrocarbon receptor	Mus musculus	62-87
30703721-2	2019	The maintenance and function of ILC3s involve the activity of aryl hydrocarbon receptor (AhR), a potent ligand of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), one of the most toxic dioxin congeners.	Dioxins	152-158	aryl-hydrocarbon receptor	Mus musculus	89-92
31096425-11	2019	Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments.	Dioxins	57-64	aryl hydrocarbon receptor 2	Danio rerio	92-96
30572237-1	2019	This research presents release inventories of unintentionally generated dioxin-like polychlorinated biphenyls (dl-PCB) and hexachlorobenzene (HCB), which so far have not been developed or assessed.	Dioxins	72-78	pyruvate carboxylase	Homo sapiens	114-117
30499018-0	2019	Targeted deletion of the aryl hydrocarbon receptor in dendritic cells prevents thymic atrophy in response to dioxin.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	25-50
30499018-1	2019	In nearly every species examined, administration of the persistent environmental pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin, TCDD) causes profound immune suppression and thymic atrophy in an aryl hydrocarbon receptor (AhR) dependent manner.	Dioxins	121-127	aryl hydrocarbon receptor	Homo sapiens	203-228
30499018-1	2019	In nearly every species examined, administration of the persistent environmental pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin, TCDD) causes profound immune suppression and thymic atrophy in an aryl hydrocarbon receptor (AhR) dependent manner.	Dioxins	121-127	aryl hydrocarbon receptor	Homo sapiens	230-233
30528028-6	2019	Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor (AhR) pathway.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	47-72
30528028-6	2019	Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor (AhR) pathway.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	74-77
30708991-1	2019	Dioxins and related compounds induce morphological abnormalities in developing animals in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	93-118
30708991-1	2019	Dioxins and related compounds induce morphological abnormalities in developing animals in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	120-123
30316103-5	2019	PAHs and dioxins are known aryl hydrocarbon receptor (AHR) ligands.	Dioxins	9-16	aryl-hydrocarbon receptor	Mus musculus	27-52
30316103-5	2019	PAHs and dioxins are known aryl hydrocarbon receptor (AHR) ligands.	Dioxins	9-16	aryl-hydrocarbon receptor	Mus musculus	54-57
31096425-11	2019	Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments.	Dioxins	57-64	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	84-90
30393115-1	2019	Hexachlorobenzene (HCB) is a dioxin-like compound widely distributed and is a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Rattus norvegicus	97-122
30393115-1	2019	Hexachlorobenzene (HCB) is a dioxin-like compound widely distributed and is a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Rattus norvegicus	124-127
30391726-0	2018	Generation of a Tg(cyp1a-12DRE:EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds.	Dioxins	102-108	cytochrome P450, family 1, subfamily A	Danio rerio	19-24
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	36-61
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	63-66
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	222-225
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	222-225
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	416-422	aryl hydrocarbon receptor	Homo sapiens	36-61
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	416-422	aryl hydrocarbon receptor	Homo sapiens	63-66
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	416-422	aryl hydrocarbon receptor	Homo sapiens	222-225
30567322-3	2018	Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	416-422	aryl hydrocarbon receptor	Homo sapiens	222-225
30567322-4	2018	2,3,7,8-TCDD is the most toxic among dioxins showing the highest affinity toward the AhR receptor.	Dioxins	37-44	aryl hydrocarbon receptor	Homo sapiens	85-88
30574142-9	2018	The AHR is a ligand activated transcription factor that responds to endogenous and exogenous ligands including toxicants present in PM, such as PAHs and dioxins.	Dioxins	153-160	aryl-hydrocarbon receptor	Mus musculus	4-7
30563036-1	2018	Much of what is known about the Aryl Hydrocarbon Receptor (AhR) centers on its ability to mediate the deleterious effects of the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin).	Dioxins	181-187	aryl hydrocarbon receptor	Homo sapiens	32-57
30563036-1	2018	Much of what is known about the Aryl Hydrocarbon Receptor (AhR) centers on its ability to mediate the deleterious effects of the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin).	Dioxins	181-187	aryl hydrocarbon receptor	Homo sapiens	59-62
30389142-0	2018	Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response.	Dioxins	50-56	lysine demethylase and nuclear receptor corepressor	Mus musculus	81-89
30373033-0	2018	Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis.	Dioxins	0-6	pyruvate carboxylase	Mus musculus	12-15
30124847-0	2018	AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.	Dioxins	9-15	aryl hydrocarbon receptor	Homo sapiens	0-3
30373043-0	2018	First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population.	Dioxins	69-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
30373043-0	2018	First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population.	Dioxins	69-75	insulin like growth factor 2	Homo sapiens	110-114
30373043-9	2018	In conclusion this study indicates that past environmental exposure to dioxin (AO/TCDD) shapes the DNAm profile of CYP1A1 and that the place of living for parents in former spray zones influences DNAm of CYP1A1 and IGF2 genes.	Dioxins	71-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-121
30373043-9	2018	In conclusion this study indicates that past environmental exposure to dioxin (AO/TCDD) shapes the DNAm profile of CYP1A1 and that the place of living for parents in former spray zones influences DNAm of CYP1A1 and IGF2 genes.	Dioxins	71-77	insulin like growth factor 2	Homo sapiens	215-219
29713743-12	2018	The estimated toxic equivalency of dioxin-like PCBs suggested that PCB-126 is the most toxic contaminant to endanger the human population.	Dioxins	35-41	pyruvate carboxylase	Homo sapiens	47-50
29864660-12	2018	Conversely, the elevated androstenedione (A-dione) level and 3beta-HSD activity in children from the hotspot were positively correlated with dioxin levels.	Dioxins	141-147	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	61-70
29864660-14	2018	It is possible that dioxin inhibits 17beta-HSD activity, leading to a decrease in the T level.	Dioxins	20-26	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	36-46
29864660-16	2018	In conclusion, the present study suggests that dioxin is associated with low levels of DHEA and T and inhibition of the activity of steroidogenic enzymes such as CYP17 lyase and 17beta-HSD in 5-year-old children.	Dioxins	47-53	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	178-188
29873790-2	2018	Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in hepatocytes is necessary for dioxin-induced liver toxicity.	Dioxins	105-111	aryl-hydrocarbon receptor	Mus musculus	59-62
29960196-9	2018	All of the mixtures induced the expression of cyp19a1b, which is a marker for (xeno-)estrogen exposure, and two of them increased the expression of cyp1a, which is used to indicate the presence of dioxin-like compounds.	Dioxins	197-203	cytochrome P450, family 1, subfamily A	Danio rerio	148-153
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	104-110
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	111-116
29873790-3	2018	We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities.	Dioxins	215-221	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	117-123
29873790-5	2018	Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 mug/kg dioxin did not survive beyond days 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment.	Dioxins	78-84	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	0-6
29873790-7	2018	Tiparpfl/flCreAlb and TiparpEx3-/- mice exhibited augmented AHR signaling, denoted by increased dioxin-induced gene expression.	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	60-63
29873790-9	2018	Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.	Dioxins	185-191	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	43-49
29908305-2	2018	Selective AHR modulators (SAHRMs) share some effects of dioxins, except for their marked toxicity.	Dioxins	56-63	aryl hydrocarbon receptor	Rattus norvegicus	10-13
29908305-1	2018	The mediator of dioxin toxicity, aryl hydrocarbon receptor (AHR), has also important physiological functions.	Dioxins	16-22	aryl hydrocarbon receptor	Rattus norvegicus	33-58
29908305-1	2018	The mediator of dioxin toxicity, aryl hydrocarbon receptor (AHR), has also important physiological functions.	Dioxins	16-22	aryl hydrocarbon receptor	Rattus norvegicus	60-63
30224706-2	2018	Exposure to a variety of toxicants including dioxin, di(2-ethylhexyl) phthalate, 6:2 chlorinated polyfluorinated ether sulfonate, and chlorpyrifos results in the downregulation of tetrapod Sox9 and/or zebrafish sox9b.	Dioxins	45-51	SRY-box transcription factor 9b	Danio rerio	211-216
29873790-0	2018	Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.	Dioxins	136-142	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	32-38
29873790-1	2018	The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	4-29
29873790-1	2018	The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	31-34
29575357-5	2018	We also analysed the ability of vemurafenib and tyrosine kinase inhibitors to induce dioxin-AhR pathway.	Dioxins	85-91	aryl hydrocarbon receptor	Homo sapiens	92-95
29995397-9	2018	Besides directly inactivating AChE, the mechanisms in terms of interference with the biosynthesis have been recognized for some emerging AChE disruptors, particularly for dioxins.	Dioxins	171-178	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-141
29753751-0	2018	The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats.	Dioxins	51-57	aryl hydrocarbon receptor	Rattus norvegicus	4-29
29753751-1	2018	Many forms of the toxic effects produced by dioxins and related chemicals take place following activation of the aryl hydrocarbon receptor (AHR).	Dioxins	44-51	aryl hydrocarbon receptor	Rattus norvegicus	113-138
29753751-1	2018	Many forms of the toxic effects produced by dioxins and related chemicals take place following activation of the aryl hydrocarbon receptor (AHR).	Dioxins	44-51	aryl hydrocarbon receptor	Rattus norvegicus	140-143
29763690-1	2018	The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR.	Dioxins	61-68	aryl hydrocarbon receptor	Homo sapiens	161-164
29575357-9	2018	The expression of CYP1A1, a gene highly induced following dioxin exposure, was not observed in these lesions.	Dioxins	58-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24
29575357-12	2018	A strong expression of CYP1A1 in the epithelial wall of dermal cysts must be required, parallel to the morphology of the lesions, to make the diagnosis of MADISH, the hallmark of an exposure to dioxin-like/chloracnegen compounds.	Dioxins	194-200	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-29
29752288-6	2018	Sequence analysis of regions with overlapping NRF2 and AhR enrichment showed over-representation of either antioxidant or dioxin response elements, although 18 possessed both motifs.	Dioxins	122-128	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
29752288-6	2018	Sequence analysis of regions with overlapping NRF2 and AhR enrichment showed over-representation of either antioxidant or dioxin response elements, although 18 possessed both motifs.	Dioxins	122-128	aryl-hydrocarbon receptor	Mus musculus	55-58
29475727-0	2018	Limited mobility of dioxins near San Jacinto super fund site (waste pit) in the Houston Ship Channel, Texas due to strong sediment sorption.	Dioxins	20-27	inositol polyphosphate-5-phosphatase D	Homo sapiens	88-92
30022311-6	2018	OCP concentration level in adipose tissue samples for healthy people was 32 times higher than for cancer patient persons, while the TEQ values for dioxin-like PCB concentrations in adipose tissue samples of healthy people was 2.2 times higher than in the samples of cancer-affected patient and the TEQ values for PCDDs/Fs in adipose tissue samples of cancer-affected patient was 3 times higher than in the samples of healthy people.	Dioxins	147-153	pyruvate carboxylase	Homo sapiens	159-162
30011787-2	2018	Dioxin activates the aryl hydrocarbon receptor (AHR)-cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	21-46
30011787-2	2018	Dioxin activates the aryl hydrocarbon receptor (AHR)-cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	48-51
30011787-2	2018	Dioxin activates the aryl hydrocarbon receptor (AHR)-cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-72
30011787-2	2018	Dioxin activates the aryl hydrocarbon receptor (AHR)-cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
30011787-6	2018	Agents with dual functions in promoting AHR-CYP1A1 inhibition and NRF2 activation may be useful for managing dioxin-related health hazards.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	40-43
30011787-6	2018	Agents with dual functions in promoting AHR-CYP1A1 inhibition and NRF2 activation may be useful for managing dioxin-related health hazards.	Dioxins	109-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
30011787-6	2018	Agents with dual functions in promoting AHR-CYP1A1 inhibition and NRF2 activation may be useful for managing dioxin-related health hazards.	Dioxins	109-115	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
29197056-10	2018	Concurrently, various phytochemicals and herbal extracts have been found to possess biological activities that suppress dioxin-induced toxicity via aryl hydrocarbon receptor or activate the antioxidant nuclear factor-erythroid 2-related factor-2 (NRF2) signal pathway, making them promising therapeutic candidates.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	148-173
29855878-5	2018	The load of PCDD/F and PCB (especially dioxin-like PCB) tends to rise rapidly with falling temperature of flue gas, reaching their highest value in economiser ashes.	Dioxins	39-45	Pyruvate carboxylase	Drosophila melanogaster	23-26
29855878-5	2018	The load of PCDD/F and PCB (especially dioxin-like PCB) tends to rise rapidly with falling temperature of flue gas, reaching their highest value in economiser ashes.	Dioxins	39-45	Pyruvate carboxylase	Drosophila melanogaster	51-54
29738842-1	2018	Toxicity of dioxin-like compounds (DLCs), such as polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls, is largely mediated via aryl hydrocarbon receptor (AhR) activation.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	138-163
29738842-1	2018	Toxicity of dioxin-like compounds (DLCs), such as polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls, is largely mediated via aryl hydrocarbon receptor (AhR) activation.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	165-168
28699004-4	2018	We show here that PCB126, a dioxin-like PCB, activates a robust proinflammatory state in fat cell precursors (preadipocytes).	Dioxins	28-34	pyruvate carboxylase	Homo sapiens	18-21
29522993-0	2018	SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cells.	Dioxins	45-52	solute carrier family 6 member 19	Homo sapiens	0-7
29522993-0	2018	SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cells.	Dioxins	45-52	aryl hydrocarbon receptor	Homo sapiens	57-60
29522993-1	2018	The aryl hydrocarbon receptor (AhR) plays an important role in mediating dioxins toxicity.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	4-29
29522993-1	2018	The aryl hydrocarbon receptor (AhR) plays an important role in mediating dioxins toxicity.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	31-34
29522993-2	2018	Currently, genes of P450 families are major research interests in studies on AhR-mediated gene alterations caused by dioxins.	Dioxins	117-124	aryl hydrocarbon receptor	Homo sapiens	77-80
29522993-6	2018	In the present study, we focused on the effects of dioxin and dioxin-like compounds on SLC6A19 expression in HepG2 cells.	Dioxins	51-57	solute carrier family 6 member 19	Homo sapiens	87-94
29522993-6	2018	In the present study, we focused on the effects of dioxin and dioxin-like compounds on SLC6A19 expression in HepG2 cells.	Dioxins	62-68	solute carrier family 6 member 19	Homo sapiens	87-94
29522993-11	2018	Our study suggested that dioxins might affect the transcription and translation of SLC6A19 in HepG2 cells, which might be a novel putative gene to assess dioxins" toxicity in amino acid transport and metabolism in liver.	Dioxins	25-32	solute carrier family 6 member 19	Homo sapiens	83-90
29522993-11	2018	Our study suggested that dioxins might affect the transcription and translation of SLC6A19 in HepG2 cells, which might be a novel putative gene to assess dioxins" toxicity in amino acid transport and metabolism in liver.	Dioxins	154-161	solute carrier family 6 member 19	Homo sapiens	83-90
29667064-0	2018	Correction to: Formation of brominated and chlorinated dioxins and its prevention during a pilot test of mechanochemical treatment of PCB and PBDE contaminated soil.	Dioxins	55-62	pyruvate carboxylase	Homo sapiens	134-137
29197056-10	2018	Concurrently, various phytochemicals and herbal extracts have been found to possess biological activities that suppress dioxin-induced toxicity via aryl hydrocarbon receptor or activate the antioxidant nuclear factor-erythroid 2-related factor-2 (NRF2) signal pathway, making them promising therapeutic candidates.	Dioxins	120-126	NFE2 like bZIP transcription factor 2	Homo sapiens	202-245
29197056-10	2018	Concurrently, various phytochemicals and herbal extracts have been found to possess biological activities that suppress dioxin-induced toxicity via aryl hydrocarbon receptor or activate the antioxidant nuclear factor-erythroid 2-related factor-2 (NRF2) signal pathway, making them promising therapeutic candidates.	Dioxins	120-126	NFE2 like bZIP transcription factor 2	Homo sapiens	247-251
29617551-2	2018	Here, we tested 34 organohalogens from anthropogenic and marine sources to identify compounds active toward ryanodine receptor (RyR1), known toxicological targets of non-dioxin-like polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).	Dioxins	170-176	ryanodine receptor 1	Homo sapiens	128-132
29626056-4	2018	The most effective agonists (EMAX relative to 5 nM dioxin) of the AhR were 4-Me-indole (134%), 6-Me-indole (91%), and 7-MeO-indole (80%), respectively.	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	66-69
29458109-3	2018	CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins.	Dioxins	222-229	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
29458109-3	2018	CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins.	Dioxins	222-229	aryl hydrocarbon receptor	Homo sapiens	46-71
29458109-3	2018	CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins.	Dioxins	222-229	aryl hydrocarbon receptor	Homo sapiens	73-76
29474705-1	2018	3,3",4,4",5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through a wide array of noncarcinogenic effects, including metabolic syndrome, wasting, and nonalcoholic fatty-liver disease.	Dioxins	44-50	pyruvate carboxylase	Rattus norvegicus	33-36
29202294-1	2018	The measurement of EROD (ethoxyresorufin-O-deethylase) activity to determine the induction of CYP1A after exposure to dioxin-like substances is a well-established biomarker in fish.	Dioxins	118-124	cytochrome P450 1A1	Oryzias latipes	94-99
29701132-0	2018	Aryl Hydrocarbon Receptor Activation: From Coal to Dioxin.	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	0-25
29223911-10	2018	Almost 70% of the  26PCB concentrations was comprised of the dioxin-like PCB congeners with a maximum concentration of 437ng/g at New Moore market in Chennai, followed by Wire Lane (102ng/g), in Mumbai.	Dioxins	61-67	pyruvate carboxylase	Homo sapiens	21-24
29522672-5	2018	Molecular dynamics simulations indicated the interaction between dioxins/dioxin-like compounds (DLCs) and six key amino acid residues in the ligand-binding domain of Ahr2 probably determined the susceptibility to dioxins/DLCs in zebrafish.	Dioxins	65-72	aryl hydrocarbon receptor 2	Danio rerio	166-170
29522672-5	2018	Molecular dynamics simulations indicated the interaction between dioxins/dioxin-like compounds (DLCs) and six key amino acid residues in the ligand-binding domain of Ahr2 probably determined the susceptibility to dioxins/DLCs in zebrafish.	Dioxins	65-71	aryl hydrocarbon receptor 2	Danio rerio	166-170
29522672-5	2018	Molecular dynamics simulations indicated the interaction between dioxins/dioxin-like compounds (DLCs) and six key amino acid residues in the ligand-binding domain of Ahr2 probably determined the susceptibility to dioxins/DLCs in zebrafish.	Dioxins	213-220	aryl hydrocarbon receptor 2	Danio rerio	166-170
29191105-1	2018	Certain dioxins, including 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD), are exogenous ligands for an aryl hydrocarbon receptor (AhR) and induces various drug-metabolizing enzymes.	Dioxins	8-15	aryl hydrocarbon receptor	Homo sapiens	102-127
29191105-1	2018	Certain dioxins, including 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD), are exogenous ligands for an aryl hydrocarbon receptor (AhR) and induces various drug-metabolizing enzymes.	Dioxins	8-15	aryl hydrocarbon receptor	Homo sapiens	129-132
29324662-5	2018	We also explored the capacity for AhR antagonists to protect against dioxin action in this context.	Dioxins	69-75	aryl hydrocarbon receptor	Homo sapiens	34-37
29353125-3	2018	We recently found that dioxin-like (DL) environmental pollutants increased FMO3 expression to elevate circulating diet-derived TMAO in mice, suggesting that exposure to this class of pollutants might also contribute to inter-individual variability in circulating TMAO levels in humans.	Dioxins	23-29	flavin containing monooxygenase 3	Mus musculus	75-79
29277905-0	2018	Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	0-25
29277905-4	2018	Here, we review the rich panel of available AhR-dependent bioassays and propose a novel classification based on the source of AhR, which can either be endogenously produced by cell types or tissues naturally responsive to dioxins, or exogenously introduced into a wide range of cellular contexts.	Dioxins	222-229	aryl hydrocarbon receptor	Homo sapiens	126-129
29216392-0	2018	Dioxin-like PCB 126 Increases Systemic Inflammation and Accelerates Atherosclerosis in Lean LDL Receptor-Deficient Mice.	Dioxins	0-6	pyruvate carboxylase	Mus musculus	12-15
29216392-0	2018	Dioxin-like PCB 126 Increases Systemic Inflammation and Accelerates Atherosclerosis in Lean LDL Receptor-Deficient Mice.	Dioxins	0-6	low density lipoprotein receptor	Mus musculus	92-104
29216392-4	2018	Here, we investigated whether a model dioxin-like pollutant, PCB 126, could increase inflammation and accelerate atherosclerosis in Ldlr-/- mice fed a low-fat atherogenic diet.	Dioxins	38-44	pyruvate carboxylase	Mus musculus	61-64
29216392-9	2018	Exposure to dioxin-like PCB 126 increases inflammation and accelerates atherosclerosis in mice.	Dioxins	12-18	pyruvate carboxylase	Mus musculus	24-27
29394403-0	2018	Arabidopsis plants exposed to dioxin result in a WRINKLED seed phenotype due to 20S proteasomal degradation of WRI1.	Dioxins	30-36	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	111-115
29437390-1	2018	Airborne persistent toxic substances are associated with health impacts resulting from air pollution, for example, dioxins, dioxin-like polychlorinated biphenyls, and certain polycyclic aromatic hydrocarbons (PAHs), which activate aryl hydrocarbon receptors (AhR) and thereby produce adverse outcomes.	Dioxins	115-122	aryl-hydrocarbon receptor	Mus musculus	259-262
28982082-1	2018	The visualization of specific activation of the aryl hydrocarbon receptor (AhR) directly in the zebrafish embryo (Danio rerio) via live-imaging is a reliable tool to investigate the presence of dioxin-like substances in environmental samples.	Dioxins	194-200	aryl hydrocarbon receptor 1a	Danio rerio	48-73
28982082-1	2018	The visualization of specific activation of the aryl hydrocarbon receptor (AhR) directly in the zebrafish embryo (Danio rerio) via live-imaging is a reliable tool to investigate the presence of dioxin-like substances in environmental samples.	Dioxins	194-200	aryl hydrocarbon receptor 1a	Danio rerio	75-78
29324662-0	2018	Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells.	Dioxins	62-68	aryl hydrocarbon receptor	Homo sapiens	0-25
29324662-3	2018	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity AhR ligand that is frequently used to investigate biological processes impacted by AhR activation.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	70-73
29324662-3	2018	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity AhR ligand that is frequently used to investigate biological processes impacted by AhR activation.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	153-156
29324662-6	2018	We found dioxin to inhibit osteogenic differentiation, whereas co-treatment with various AhR antagonists protected against dioxin action.	Dioxins	123-129	aryl hydrocarbon receptor	Homo sapiens	89-92
29324662-8	2018	Similarly, the dioxin-mediated inhibition of cell migration correlated with reduced expression of the chemokine receptor CXCR4 and its ligand, CXCL12, and co-treatment with antagonists restored migratory capacity.	Dioxins	15-21	C-X-C motif chemokine receptor 4	Homo sapiens	121-126
29324662-8	2018	Similarly, the dioxin-mediated inhibition of cell migration correlated with reduced expression of the chemokine receptor CXCR4 and its ligand, CXCL12, and co-treatment with antagonists restored migratory capacity.	Dioxins	15-21	C-X-C motif chemokine ligand 12	Homo sapiens	143-149
29339976-0	2018	Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5"-methylcytosine at the end.	Dioxins	13-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-57
29339976-6	2018	By using the samples prepared by this method, a dioxin-induced change in the methylation level of the mouse Cyp1a1 promoter was successfully evaluated using oligonucleotide probes covalently bound onto a glass plate.	Dioxins	48-54	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	108-114
29804525-1	2018	BACKGROUND: Cytochrome P450 2S1 (CYP2S1) is one of the "orphan" CYPs, which is expressed primarily among extra-hepatic tissues and it is inducible by dioxin.	Dioxins	150-156	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	12-31
29320557-4	2018	AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP).	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	0-3
29804525-1	2018	BACKGROUND: Cytochrome P450 2S1 (CYP2S1) is one of the "orphan" CYPs, which is expressed primarily among extra-hepatic tissues and it is inducible by dioxin.	Dioxins	150-156	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	33-39
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Dioxins	178-184	Kruppel-like factor 9 L homeolog	Xenopus laevis	0-21
29127629-2	2018	AhR is a key target for dioxin-like compounds, which is related to these compounds" potential to induce cancer and a wide range of endocrine and immune system-related effects.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	0-3
28782227-8	2018	Furthermore, AR-Q13 (but not AR-Q25, or -35) enhances BaP-induced dioxin-responsive element (DRE) activity.	Dioxins	66-72	androgen receptor	Homo sapiens	13-15
28782227-8	2018	Furthermore, AR-Q13 (but not AR-Q25, or -35) enhances BaP-induced dioxin-responsive element (DRE) activity.	Dioxins	66-72	prohibitin 2	Homo sapiens	54-57
29406108-7	2018	We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3"-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells.	Dioxins	200-206	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-87
29406108-7	2018	We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3"-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells.	Dioxins	200-206	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
29406108-8	2018	Functional bioinformatic analysis showed that the known and predicted target genes of hsa-miR-146b-5p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which AChE may serve as a responsive gene for mediating the effect.	Dioxins	176-182	acetylcholinesterase (Cartwright blood group)	Homo sapiens	233-237
29848869-8	2018	Maternal exposure to POPs, such as PCB/dioxins and perfluorinated alkyl substances, has affected not only children"s birth size, thyroid functions, and sex hormone levels, but also postnatal neurodevelopment, infection, and allergy among others.	Dioxins	39-46	pyruvate carboxylase	Homo sapiens	35-38
29848869-10	2018	Gene-environment interactions have been found for smoking, caffeine, folic acid, and PCB/dioxin.	Dioxins	89-95	pyruvate carboxylase	Homo sapiens	85-88
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Dioxins	178-184	Kruppel-like factor 9 L homeolog	Xenopus laevis	23-27
29096558-2	2017	Dioxins may be involved in the pathogenesis of inflammatory diseases in part via by affecting expression of aryl hydrocarbon receptor (Ahr) and inflammatory cytokines in animal models.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	108-133
29289296-8	2017	Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin.	Dioxins	110-116	early growth response 1	Rattus norvegicus	34-38
29289296-8	2017	Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin.	Dioxins	110-116	glutamate decarboxylase 2	Rattus norvegicus	40-44
29289296-8	2017	Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin.	Dioxins	110-116	gamma-aminobutyric acid type A receptor subunit beta 3	Rattus norvegicus	46-52
29289296-8	2017	Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin.	Dioxins	110-116	ATP binding cassette subfamily A member 1	Rattus norvegicus	54-59
29289296-8	2017	Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin.	Dioxins	110-116	C-C motif chemokine receptor 5	Rattus norvegicus	61-65
29096558-2	2017	Dioxins may be involved in the pathogenesis of inflammatory diseases in part via by affecting expression of aryl hydrocarbon receptor (Ahr) and inflammatory cytokines in animal models.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	135-138
29096558-10	2017	Analyses also showed that expression levels of Ahr correlated to those of IL-6 and IL-22 in the dioxin-exposed people.	Dioxins	96-102	aryl hydrocarbon receptor	Homo sapiens	47-50
29096558-10	2017	Analyses also showed that expression levels of Ahr correlated to those of IL-6 and IL-22 in the dioxin-exposed people.	Dioxins	96-102	interleukin 6	Homo sapiens	74-78
29096558-10	2017	Analyses also showed that expression levels of Ahr correlated to those of IL-6 and IL-22 in the dioxin-exposed people.	Dioxins	96-102	interleukin 22	Homo sapiens	83-88
29096558-11	2017	Taken together, dioxins might be involved in an up-regulated expression of Ahr that might possibly relate to changes in level of inflammatory cytokines and, ultimately, in the incidence of select diseases in residents of Vietnam who had/continue to live near a dioxins-contaminated site.	Dioxins	16-23	aryl hydrocarbon receptor	Homo sapiens	75-78
29096558-11	2017	Taken together, dioxins might be involved in an up-regulated expression of Ahr that might possibly relate to changes in level of inflammatory cytokines and, ultimately, in the incidence of select diseases in residents of Vietnam who had/continue to live near a dioxins-contaminated site.	Dioxins	261-268	aryl hydrocarbon receptor	Homo sapiens	75-78
28947237-3	2017	Detailed analysis of PCB burden of the participants revealed rather high correlations of lower and higher chlorinated as well as dioxin-like PCBs.	Dioxins	129-135	pyruvate carboxylase	Homo sapiens	21-24
28198024-2	2017	Aflatoxins (AF) are worldwide contaminants of food and feed commodities, while PCB 126 is a dioxin-like PCB which may contaminate milk and dairy products.	Dioxins	92-98	pyruvate carboxylase	Bos taurus	79-82
28198024-2	2017	Aflatoxins (AF) are worldwide contaminants of food and feed commodities, while PCB 126 is a dioxin-like PCB which may contaminate milk and dairy products.	Dioxins	92-98	pyruvate carboxylase	Bos taurus	104-107
28673560-0	2017	Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells.	Dioxins	115-121	alcohol dehydrogenase 4 (class II), pi polypeptide	Homo sapiens	37-60
28673560-0	2017	Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells.	Dioxins	115-121	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	65-71
28673560-5	2017	Experiments with siRNA and AHR agonists and antagonist demonstrated that the genomic AHR/ARNT pathway is necessary for the dioxin effect.	Dioxins	123-129	aryl hydrocarbon receptor	Homo sapiens	27-30
28639323-0	2017	Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.	Dioxins	26-33	nuclear receptor subfamily 1 group I member 2	Homo sapiens	65-68
28639323-0	2017	Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.	Dioxins	26-33	nuclear receptor subfamily 1 group I member 3	Homo sapiens	73-76
28673560-5	2017	Experiments with siRNA and AHR agonists and antagonist demonstrated that the genomic AHR/ARNT pathway is necessary for the dioxin effect.	Dioxins	123-129	aryl hydrocarbon receptor	Homo sapiens	85-88
29048649-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known in mediating the toxicities of dioxins and dioxin-like compounds.	Dioxins	129-136	aryl hydrocarbon receptor	Homo sapiens	4-29
28673560-5	2017	Experiments with siRNA and AHR agonists and antagonist demonstrated that the genomic AHR/ARNT pathway is necessary for the dioxin effect.	Dioxins	123-129	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	89-93
28978690-8	2017	Additionally, binding of the ligand-activated AHR to the putative dioxin response elements in the EBF1 promoter was demonstrated by EMSAs and chromatin immunoprecipitation analysis, suggesting transcriptional regulation of EBF1 by AHR.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	46-49
28978690-8	2017	Additionally, binding of the ligand-activated AHR to the putative dioxin response elements in the EBF1 promoter was demonstrated by EMSAs and chromatin immunoprecipitation analysis, suggesting transcriptional regulation of EBF1 by AHR.	Dioxins	66-72	EBF transcription factor 1	Homo sapiens	98-102
28978690-8	2017	Additionally, binding of the ligand-activated AHR to the putative dioxin response elements in the EBF1 promoter was demonstrated by EMSAs and chromatin immunoprecipitation analysis, suggesting transcriptional regulation of EBF1 by AHR.	Dioxins	66-72	EBF transcription factor 1	Homo sapiens	223-227
28978690-8	2017	Additionally, binding of the ligand-activated AHR to the putative dioxin response elements in the EBF1 promoter was demonstrated by EMSAs and chromatin immunoprecipitation analysis, suggesting transcriptional regulation of EBF1 by AHR.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	231-234
29657921-9	2017	The induction of four cyp1 genes (cyp1a, cyp1b1, cyp1c1 and cyp1c2) by both BDE congeners warrants further study to understand the in vivo metabolism of BDE-47 and BDE-99 and the dioxin-like toxicity potencies of the OH-/MeO-PBDEs.	Dioxins	179-185	peptidylprolyl isomerase Aa (cyclophilin A)	Danio rerio	22-26
29657921-9	2017	The induction of four cyp1 genes (cyp1a, cyp1b1, cyp1c1 and cyp1c2) by both BDE congeners warrants further study to understand the in vivo metabolism of BDE-47 and BDE-99 and the dioxin-like toxicity potencies of the OH-/MeO-PBDEs.	Dioxins	179-185	cytochrome P450, family 1, subfamily A	Danio rerio	34-39
29657921-9	2017	The induction of four cyp1 genes (cyp1a, cyp1b1, cyp1c1 and cyp1c2) by both BDE congeners warrants further study to understand the in vivo metabolism of BDE-47 and BDE-99 and the dioxin-like toxicity potencies of the OH-/MeO-PBDEs.	Dioxins	179-185	cytochrome P450, family 1, subfamily C, polypeptide 2	Danio rerio	60-66
28764121-2	2017	Toxic planar halogenated aromatic hydrocarbons, including dioxin and PCBs, are capable of activating the AHR, and while dioxin and PCB inputs into the environment have been dramatically curbed following strict regulatory efforts in the United States, they persist in the environment and exposures remain relevant today.	Dioxins	58-64	aryl hydrocarbon receptor	Alligator mississippiensis	105-108
28764121-7	2017	When comparisons across different sites are made, hepatic expression of CYP1A2, a direct target of the AHR, appears elevated in embryos from a site associated with a dioxin point source and previously characterized PCB contamination.	Dioxins	166-172	aryl hydrocarbon receptor	Alligator mississippiensis	103-106
29048649-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known in mediating the toxicities of dioxins and dioxin-like compounds.	Dioxins	129-136	aryl hydrocarbon receptor	Homo sapiens	31-34
29048649-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known in mediating the toxicities of dioxins and dioxin-like compounds.	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	4-29
29048649-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known in mediating the toxicities of dioxins and dioxin-like compounds.	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	31-34
28923513-0	2017	A dioxin-like compound induces hyperplasia and branching morphogenesis in mouse mammary gland, through alterations in TGF-beta1 and aryl hydrocarbon receptor signaling.	Dioxins	2-8	transforming growth factor, beta 1	Mus musculus	118-127
28923513-0	2017	A dioxin-like compound induces hyperplasia and branching morphogenesis in mouse mammary gland, through alterations in TGF-beta1 and aryl hydrocarbon receptor signaling.	Dioxins	2-8	aryl-hydrocarbon receptor	Mus musculus	132-157
28923513-1	2017	Hexachlorobenzene (HCB) is a widespread environmental pollutant and a dioxin-like compound that binds weakly to the aryl hydrocarbon receptor (AhR).	Dioxins	70-76	aryl-hydrocarbon receptor	Mus musculus	116-141
28923513-1	2017	Hexachlorobenzene (HCB) is a widespread environmental pollutant and a dioxin-like compound that binds weakly to the aryl hydrocarbon receptor (AhR).	Dioxins	70-76	aryl-hydrocarbon receptor	Mus musculus	143-146
28676433-1	2017	Our previous study showed that the environmental neurotoxicant non-dioxin-like polychlorinated biphenyl (PCB)-95 increases RE1-silencing transcription factor (REST) expression, which is related to necrosis, but not apoptosis, of neurons.	Dioxins	67-73	RE1-silencing transcription factor	Rattus norvegicus	123-157
28618207-0	2017	Effect of dioxin and 17beta-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.	Dioxins	10-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-78
28618207-0	2017	Effect of dioxin and 17beta-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.	Dioxins	10-16	estrogen receptor 1	Homo sapiens	91-108
28384582-3	2017	World Health Organization (WHO) toxic equivalency concentrations (WHO TEQ2005) for PCDD/F+dioxin-like (DL) PCB ranged from 2.2pg TEQ2005 g-1 lipid to 27pg TEQ2005 g-1 lipid.	Dioxins	90-96	pyruvate carboxylase	Homo sapiens	107-110
28592194-2	2017	2,3",4,4",5-Pentachlorobiphenyl, known as PCB-118, is a member of coplanar PCBs which renders their structure similar to polychlorinated dibenzo-p-dioxins (PCDDs) and has dioxin-like activity.	Dioxins	147-153	pyruvate carboxylase	Homo sapiens	42-45
28957439-0	2017	Skeletal and dental effects on rats following in utero/lactational exposure to the non-dioxin-like polychlorinated biphenyl PCB 180.	Dioxins	87-93	pyruvate carboxylase	Rattus norvegicus	124-127
28669845-4	2017	The 2,3,7,8-TCDD-relative potencies (REPs) of most of the brominated dioxins were within a factor of 10 of the WHO toxicity equivalency factor (WHO-TEF) for the chlorinated analogues.	Dioxins	69-76	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	148-151
28898241-8	2017	RESULTS: Prenatal dioxin (PCDD/F) exposure was positively correlated to the glucose:insulin ratio (p = 0.024) and negatively correlated to the fasting insulin concentration (p = 0.017) in adolescence.	Dioxins	18-24	insulin	Homo sapiens	84-91
28898241-8	2017	RESULTS: Prenatal dioxin (PCDD/F) exposure was positively correlated to the glucose:insulin ratio (p = 0.024) and negatively correlated to the fasting insulin concentration (p = 0.017) in adolescence.	Dioxins	18-24	insulin	Homo sapiens	151-158
28391007-5	2017	Concurrently, toxicological studies have also allowed a greater insight into the potencies of some congeners, a number of which are known to elicit potent, aryl hydrocarbon receptor (AhR) mediated responses, often referred to as dioxin-like toxicity.	Dioxins	229-235	aryl hydrocarbon receptor	Homo sapiens	156-181
28865728-0	2017	Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study.	Dioxins	47-53	H19 imprinted maternally expressed transcript	Homo sapiens	129-172
28865728-11	2017	CONCLUSION: Our results suggest that the dose-dependent association between prenatal exposure to specific non-dioxin-like PCBs and increases in the H19 and LINE-1 methylation levels in cord blood might be more predominant in females than in males.	Dioxins	110-116	H19 imprinted maternally expressed transcript	Homo sapiens	148-151
28860601-10	2017	These results indicated that AhR not only mediates transcriptional induction of CDC42, but also hsa-miR-608-induced post-transcriptional regulation of CDC42 in dioxin treated neuroblastoma cells.	Dioxins	160-166	aryl hydrocarbon receptor	Homo sapiens	29-32
28860601-10	2017	These results indicated that AhR not only mediates transcriptional induction of CDC42, but also hsa-miR-608-induced post-transcriptional regulation of CDC42 in dioxin treated neuroblastoma cells.	Dioxins	160-166	microRNA 608	Homo sapiens	96-107
28860601-10	2017	These results indicated that AhR not only mediates transcriptional induction of CDC42, but also hsa-miR-608-induced post-transcriptional regulation of CDC42 in dioxin treated neuroblastoma cells.	Dioxins	160-166	cell division cycle 42	Homo sapiens	151-156
28839207-6	2017	Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	148-151
28820910-3	2017	Although the endogenous ligand involved in brain developmental process has not been identified, the environmental pollutant dioxin potently binds AhR and induces abnormalities in higher brain function of laboratory animals.	Dioxins	124-130	aryl-hydrocarbon receptor	Mus musculus	146-149
28820910-9	2017	The present results indicate that over-activation of AhR perturbs neuronal migration and morphological development in mammalian cortex, supporting previous observations of impaired dendritic structure, cortical dysgenesis, and behavioral abnormalities following perinatal dioxin exposure.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	53-56
27458090-10	2017	Both dioxin and non-dioxin-like PCB congeners decreased EGFR phosphorylation in cell culture.	Dioxins	5-11	epidermal growth factor receptor	Homo sapiens	56-60
27458090-10	2017	Both dioxin and non-dioxin-like PCB congeners decreased EGFR phosphorylation in cell culture.	Dioxins	20-26	pyruvate carboxylase	Homo sapiens	32-35
27458090-10	2017	Both dioxin and non-dioxin-like PCB congeners decreased EGFR phosphorylation in cell culture.	Dioxins	20-26	epidermal growth factor receptor	Homo sapiens	56-60
28860601-0	2017	CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells.	Dioxins	31-37	cell division cycle 42	Homo sapiens	0-5
28702904-0	2017	Formation of brominated and chlorinated dioxins and its prevention during a pilot test of mechanochemical treatment of PCB and PBDE contaminated soil.	Dioxins	40-47	pyruvate carboxylase	Homo sapiens	119-122
28634910-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes.	Dioxins	190-196	aryl-hydrocarbon receptor	Mus musculus	4-29
28634910-1	2017	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes.	Dioxins	190-196	aryl-hydrocarbon receptor	Mus musculus	31-34
28602820-2	2017	AHR is activated by xenobiotics, notably dioxin, as well as by exogenous and endogenous metabolites.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	0-3
28661416-4	2017	Dioxin-like PCB congeners (DL-PCBs) were poorly represented in all biological samples, whereas non Dioxin-Like PCB congeners (noDL-PCBs), in particular environmentally widespread congeners (PCB 153, 138, 180), could be detected in almost all samples.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	12-15
28661416-4	2017	Dioxin-like PCB congeners (DL-PCBs) were poorly represented in all biological samples, whereas non Dioxin-Like PCB congeners (noDL-PCBs), in particular environmentally widespread congeners (PCB 153, 138, 180), could be detected in almost all samples.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	30-33
28661416-4	2017	Dioxin-like PCB congeners (DL-PCBs) were poorly represented in all biological samples, whereas non Dioxin-Like PCB congeners (noDL-PCBs), in particular environmentally widespread congeners (PCB 153, 138, 180), could be detected in almost all samples.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	30-33
28487374-0	2017	Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	67-92
28487374-1	2017	Dioxin and related chemicals alter the expression of a number of genes by activating the aryl hydrocarbon receptors (AHR) to produce a variety of disorders including hepatotoxicity.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	89-115
28487374-1	2017	Dioxin and related chemicals alter the expression of a number of genes by activating the aryl hydrocarbon receptors (AHR) to produce a variety of disorders including hepatotoxicity.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	117-120
28478156-0	2017	Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	62-87
28478156-0	2017	Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.	Dioxins	45-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103
28478156-6	2017	Incubation of human hepatocytes with T3 had modulatory and inter-individual (7 cell cultures from 7 different liver donors) effects on both basal and dioxin-inducible CYP1A1/2.	Dioxins	150-156	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	167-173
27853917-2	2017	Epidemiological data reported increased prevalence of pituitary tumors in high industrial areas while genotyping studies showed that mutations in the aryl hydrocarbon receptor (AhR) interacting protein (AIP)-chaperone to the dioxin ligand AhR-gene are linked to predisposition to pituitary tumor development.	Dioxins	225-231	aryl hydrocarbon receptor	Rattus norvegicus	150-175
27853917-2	2017	Epidemiological data reported increased prevalence of pituitary tumors in high industrial areas while genotyping studies showed that mutations in the aryl hydrocarbon receptor (AhR) interacting protein (AIP)-chaperone to the dioxin ligand AhR-gene are linked to predisposition to pituitary tumor development.	Dioxins	225-231	aryl hydrocarbon receptor	Rattus norvegicus	177-180
27853917-2	2017	Epidemiological data reported increased prevalence of pituitary tumors in high industrial areas while genotyping studies showed that mutations in the aryl hydrocarbon receptor (AhR) interacting protein (AIP)-chaperone to the dioxin ligand AhR-gene are linked to predisposition to pituitary tumor development.	Dioxins	225-231	aryl hydrocarbon receptor	Rattus norvegicus	239-242
28158694-3	2017	In vivo, transformation of dioxins occurs after their interaction with the aryl hydrocarbon receptor (AhR) and leads to formation of proinflammatory and toxic metabolites.	Dioxins	27-34	aryl hydrocarbon receptor 1 alpha	Gallus gallus	75-100
28158694-3	2017	In vivo, transformation of dioxins occurs after their interaction with the aryl hydrocarbon receptor (AhR) and leads to formation of proinflammatory and toxic metabolites.	Dioxins	27-34	aryl hydrocarbon receptor 1 alpha	Gallus gallus	102-105
28396409-2	2017	The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream genes.	Dioxins	112-118	aryl hydrocarbon receptor	Homo sapiens	4-7
28396409-2	2017	The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream genes.	Dioxins	112-118	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	58-62
28396409-2	2017	The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream genes.	Dioxins	112-118	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	64-88
28481916-3	2017	Here we investigate the hypothesis that TCF21 interacts with a downstream target gene, the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the cellular response to environmental contaminants, including dioxin and polycyclic aromatic hydrocarbons (e.g., tobacco smoke).	Dioxins	241-247	transcription factor 21	Homo sapiens	40-45
28481916-3	2017	Here we investigate the hypothesis that TCF21 interacts with a downstream target gene, the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the cellular response to environmental contaminants, including dioxin and polycyclic aromatic hydrocarbons (e.g., tobacco smoke).	Dioxins	241-247	aryl hydrocarbon receptor	Homo sapiens	118-121
28552310-1	2017	In 2011, a joint World Health Organization (WHO) and United Nations Environment Programme expert panel recommended the use of the WHO toxicity equivalency factor (TEF) scheme for assessment of the human health risks of brominated dioxins which have different sources from chlorinated dioxins.	Dioxins	284-291	TEF transcription factor, PAR bZIP family member	Homo sapiens	163-166
28433708-1	2017	The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxins, but also plays important physiological roles.	Dioxins	61-68	aryl hydrocarbon receptor	Rattus norvegicus	4-29
28433708-1	2017	The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxins, but also plays important physiological roles.	Dioxins	61-68	aryl hydrocarbon receptor	Rattus norvegicus	31-34
28433708-2	2017	Selective AHR modulators, which elicit some effects imparted by this receptor without causing the marked toxicity of dioxins, are presently under intense scrutiny.	Dioxins	117-124	aryl hydrocarbon receptor	Rattus norvegicus	10-13
28485586-9	2017	Therefore, strain p52 harboring pDF01 and pDF02 has potential for genetic bioaugmentation in dioxin-contaminated environments.	Dioxins	93-99	nuclear factor kappa B subunit 2	Homo sapiens	18-21
27837308-2	2017	In this study, we examined in vitro and in vivo effects of PCB-118 (dioxin-like PCB) and PCB-138 (non-dioxin-like PCB) on adipocyte differentiation, lipid droplet growth, and insulin action.	Dioxins	68-74	pyruvate carboxylase	Mus musculus	80-83
27837308-2	2017	In this study, we examined in vitro and in vivo effects of PCB-118 (dioxin-like PCB) and PCB-138 (non-dioxin-like PCB) on adipocyte differentiation, lipid droplet growth, and insulin action.	Dioxins	68-74	pyruvate carboxylase	Mus musculus	80-83
27837308-2	2017	In this study, we examined in vitro and in vivo effects of PCB-118 (dioxin-like PCB) and PCB-138 (non-dioxin-like PCB) on adipocyte differentiation, lipid droplet growth, and insulin action.	Dioxins	68-74	pyruvate carboxylase	Mus musculus	80-83
28536482-3	2017	However, after nearly 50 years of study, it remains unknown how AhR activation by dioxin produces toxic effects.	Dioxins	82-88	aryl hydrocarbon receptor 1 alpha	Gallus gallus	64-67
28536482-6	2017	Our findings additionally support a role for decreased NAD+ dependent Sirt6 activity in mediating dioxin toxicity following PARP activation.	Dioxins	98-104	sirtuin 6	Gallus gallus	70-75
28391007-5	2017	Concurrently, toxicological studies have also allowed a greater insight into the potencies of some congeners, a number of which are known to elicit potent, aryl hydrocarbon receptor (AhR) mediated responses, often referred to as dioxin-like toxicity.	Dioxins	229-235	aryl hydrocarbon receptor	Homo sapiens	183-186
28476168-0	2017	Dioxins and related environmental contaminants increase TDP-43 levels.	Dioxins	0-7	TAR DNA binding protein	Mus musculus	56-62
28476168-3	2017	Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	151-176
28476168-3	2017	Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	178-181
27805907-0	2017	Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	17-42
28267985-3	2017	Tested compounds are shown to activate the receptors but to much lesser extent than positive controls, dioxin and dexamethasone for Ahr and GR, respectively.	Dioxins	103-109	aryl hydrocarbon receptor	Homo sapiens	132-135
28267985-3	2017	Tested compounds are shown to activate the receptors but to much lesser extent than positive controls, dioxin and dexamethasone for Ahr and GR, respectively.	Dioxins	103-109	nuclear receptor subfamily 3 group C member 1	Homo sapiens	140-142
27805907-0	2017	Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	44-47
27805907-1	2017	Metabolism of aryl hydrocarbons and toxicity of dioxins led to the discovery of the aryl hydrocarbon receptor (AHR).	Dioxins	48-55	aryl hydrocarbon receptor	Homo sapiens	84-109
27805907-1	2017	Metabolism of aryl hydrocarbons and toxicity of dioxins led to the discovery of the aryl hydrocarbon receptor (AHR).	Dioxins	48-55	aryl hydrocarbon receptor	Homo sapiens	111-114
27805907-4	2017	Observations in dioxin-poisoned individuals may provide hints to physiologic AHR functions in humans.	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	77-80
28192119-4	2017	The toxicity profiles of the classical AhR ligands such as 3-methylcholanthrene and dioxins limit their use as a therapeutic agent in humans.	Dioxins	84-91	aryl hydrocarbon receptor	Homo sapiens	39-42
27942866-3	2017	Dioxins are transformed in vivo, and interactions between the products and the aryl hydrocarbon receptor (AhR) lead to the formation of proinflammatory and toxic metabolites.	Dioxins	0-7	aryl hydrocarbon receptor 1 alpha	Gallus gallus	79-104
27942866-3	2017	Dioxins are transformed in vivo, and interactions between the products and the aryl hydrocarbon receptor (AhR) lead to the formation of proinflammatory and toxic metabolites.	Dioxins	0-7	aryl hydrocarbon receptor 1 alpha	Gallus gallus	106-109
27888289-6	2017	This selectivity was mediated by AhR"s binding to the distal dioxin-responsive element (DRE) in the CCL1 promoter of the M(IL-4) subset, and a deletion mutant lacking the distal DRE sequence lost its activity.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	33-36
27888289-6	2017	This selectivity was mediated by AhR"s binding to the distal dioxin-responsive element (DRE) in the CCL1 promoter of the M(IL-4) subset, and a deletion mutant lacking the distal DRE sequence lost its activity.	Dioxins	61-67	C-C motif chemokine ligand 1	Homo sapiens	100-104
27888289-6	2017	This selectivity was mediated by AhR"s binding to the distal dioxin-responsive element (DRE) in the CCL1 promoter of the M(IL-4) subset, and a deletion mutant lacking the distal DRE sequence lost its activity.	Dioxins	61-67	interleukin 4	Homo sapiens	121-127
28284726-4	2017	In adiponectin stimulated cells dioxin-like compounds decreased E2 and except of PCN had no effect on T, while non-dioxin like increased E2 and decreased T secretion.	Dioxins	32-38	adiponectin, C1Q and collagen domain containing	Homo sapiens	3-14
28284726-5	2017	Results indicated to modulatory role of EDCs on adiponectin and its receptor and its action on ovarian steroidogenesis, suggest that dioxin- like compounds may contribute to the ovarian dysfunction in obesity-related disorders.	Dioxins	133-139	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
28270159-8	2017	CONCLUSIONS: This cross-sectional analysis which controlled for collinear exposure to several neurotoxic compounds demonstrated an association between non-dioxin like polychlorinated biphenyl exposure, specifically PCB 146, and lower cognitive functioning, in older adults.	Dioxins	155-161	pyruvate carboxylase	Homo sapiens	215-218
28049042-9	2017	Structure-activity relationship studies using dioxin congeners demonstrated a correlation between the relative AHR binding affinity and the magnitude of decrease in the number of HSPCs and CD34 expression, suggesting that AHR mediates the observed TCDD-elicited changes in HSPCs.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	111-114
28049042-9	2017	Structure-activity relationship studies using dioxin congeners demonstrated a correlation between the relative AHR binding affinity and the magnitude of decrease in the number of HSPCs and CD34 expression, suggesting that AHR mediates the observed TCDD-elicited changes in HSPCs.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	222-225
27604104-1	2017	Dioxins cause various toxic effects through the aryl hydrocarbon receptor (AHR) in vertebrates, with dramatic species and strain differences in susceptibility.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	48-73
27604104-1	2017	Dioxins cause various toxic effects through the aryl hydrocarbon receptor (AHR) in vertebrates, with dramatic species and strain differences in susceptibility.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	75-78
27604104-7	2017	Taken together, our results provide insights into the molecular mechanism underlying the high dioxin susceptibility of the C3H/lpr strain, in which AHR activation by TBDD is more prompted by the production of endogenous ligands, but the adaptation to oxidative stress is also acquired.	Dioxins	94-100	aryl-hydrocarbon receptor	Mus musculus	148-151
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Dioxins	183-190	fibroblast growth factor 21	Mus musculus	0-33
28377982-3	2017	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity Ahr ligand frequently used to evaluate Ahr pathway activation.	Dioxins	29-35	aryl hydrocarbon receptor	Rattus norvegicus	70-73
28377982-3	2017	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity Ahr ligand frequently used to evaluate Ahr pathway activation.	Dioxins	29-35	aryl hydrocarbon receptor	Rattus norvegicus	109-112
28377982-4	2017	The purpose of this study was to elucidate the downstream mechanisms of dioxin action on bone regeneration and investigate Ahr antagonism as a potential therapeutic approach to mitigate the effects of dioxin on bone.	Dioxins	201-207	aryl hydrocarbon receptor	Rattus norvegicus	123-126
28377982-9	2017	RNA and protein expression studies found that dioxin down-regulated numerous pro-osteogenic targets, whereas co-treatment with Ahr antagonists prevented these dioxin-induced expression changes to varying degrees.	Dioxins	159-165	aryl hydrocarbon receptor	Rattus norvegicus	127-130
28377982-10	2017	Our results suggest that dioxin adversely affects bone regeneration in a myriad of ways, many of which appear to be mediated by the Ahr.	Dioxins	25-31	aryl hydrocarbon receptor	Rattus norvegicus	132-135
27956220-4	2017	This model incorporates CYP1A2 induction, which is an important metabolic vector that drives dioxin distribution in the human body, and it uses a variable elimination half-life that is body burden dependent.	Dioxins	93-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-30
28029781-3	2017	It has been shown that some environmental organic pollutants (POPs) like dioxins, furans, and polychlorinated biphenyls (PCBs) may act as ligands for the aryl hydrocarbon receptor (AhR) and regulate hyperpigmentation.	Dioxins	73-80	aryl-hydrocarbon receptor	Mus musculus	154-179
28029781-3	2017	It has been shown that some environmental organic pollutants (POPs) like dioxins, furans, and polychlorinated biphenyls (PCBs) may act as ligands for the aryl hydrocarbon receptor (AhR) and regulate hyperpigmentation.	Dioxins	73-80	aryl-hydrocarbon receptor	Mus musculus	181-184
28944315-1	2017	There is a long standing perception that AhR ligands are automatically disqualified from pharmaceutical development due to their induction of Cyp1a1 as well as their potential for causing "dioxin-like" toxicities.	Dioxins	189-195	aryl hydrocarbon receptor	Homo sapiens	41-44
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor repressor	Homo sapiens	4-39
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor repressor	Homo sapiens	41-45
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor	Homo sapiens	4-29
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor	Homo sapiens	41-44
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	189-213
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	215-219
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor	Homo sapiens	133-136
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	259-263
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor repressor	Homo sapiens	268-272
28971163-1	2017	The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs).	Dioxins	303-309	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	259-263
28223923-2	2017	Dioxin, a ubiquitous environmental pollutant, avidly binds to this receptor, and maternal exposure to dioxin has been shown to impair higher brain functions and dendritic morphogenesis, possibly via an AhR-dependent mechanism.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	202-205
28223923-2	2017	Dioxin, a ubiquitous environmental pollutant, avidly binds to this receptor, and maternal exposure to dioxin has been shown to impair higher brain functions and dendritic morphogenesis, possibly via an AhR-dependent mechanism.	Dioxins	102-108	aryl-hydrocarbon receptor	Mus musculus	202-205
27839925-0	2017	Dioxin-like pcb emissions from cement kilns during the use of alternative fuels.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	12-15
27839925-3	2017	This paper presents stack emission monitoring of health-critical dl-PCB (dioxin-like polychlorinated biphenyl) congeners during the substitution of alternative fuels at ten Australian cement plants, and to distinguish statistical similarities between other key pollutants (such as polychlorinated dibenzo-p-dioxins and furans (PCDD-F) and hydrogen halogens) and amongst the fuels used.	Dioxins	73-79	pyruvate carboxylase	Homo sapiens	68-71
26856715-5	2017	Interestingly, ICZ is a potent activator of the aryl hydrocarbon receptor (AhR), a transcription factor known to mediate toxic effects of environmental pollutants, such as dioxin and polycyclic aromatic hydrocarbons.	Dioxins	172-178	aryl hydrocarbon receptor	Homo sapiens	48-73
26856715-5	2017	Interestingly, ICZ is a potent activator of the aryl hydrocarbon receptor (AhR), a transcription factor known to mediate toxic effects of environmental pollutants, such as dioxin and polycyclic aromatic hydrocarbons.	Dioxins	172-178	aryl hydrocarbon receptor	Homo sapiens	75-78
27783961-3	2017	In living organisms, dioxins are metabolized by enzymes of the cytochrome P450 family, including CYP1A1.	Dioxins	21-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103
27783961-5	2017	Since the molecular mechanisms underlying dioxin susceptibility or resistance to biodegradation are unknown, in the present study the molecular interactions between five selected dioxins and porcine CYP1A1 protein were investigated.	Dioxins	179-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	199-205
27783961-6	2017	It was found that the ability of a dioxin to undergo CYP1A1-mediated degradation is associated mainly with the number and position of chlorine atoms in the dioxin molecule.	Dioxins	35-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
27783961-6	2017	It was found that the ability of a dioxin to undergo CYP1A1-mediated degradation is associated mainly with the number and position of chlorine atoms in the dioxin molecule.	Dioxins	156-162	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
27783961-8	2017	Interestingly, in contrast to other dioxins, the binding of the TCDD molecule to the porcine CYP1A1 active site resulted in a rapid and continuous closure of substrate channels.	Dioxins	36-43	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
27994169-2	2017	We capitalize on a recent genome duplication in Xenopus laevis (African clawed frog) to interrogate possible functional differentiation between alloalleles of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates toxicity of dioxin-like compounds and plays a role in the physiology and development of the cardiovascular, hepatic, and immune systems in vertebrates.	Dioxins	262-268	aryl hydrocarbon receptor L homeolog	Xenopus laevis	163-188
27994169-2	2017	We capitalize on a recent genome duplication in Xenopus laevis (African clawed frog) to interrogate possible functional differentiation between alloalleles of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates toxicity of dioxin-like compounds and plays a role in the physiology and development of the cardiovascular, hepatic, and immune systems in vertebrates.	Dioxins	262-268	aryl hydrocarbon receptor L homeolog	Xenopus laevis	190-193
28079158-1	2017	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin.	Dioxins	153-159	aryl hydrocarbon receptor	Homo sapiens	4-29
28079158-1	2017	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin.	Dioxins	153-159	aryl hydrocarbon receptor	Homo sapiens	31-34
27349986-3	2017	Hints to physiologic functions may be derived (i) from feedback loops between endogenous ligands and substrates of major target enzymes such as CYP1A1 and UGT1A1, and (ii) from dioxin toxicity in human individuals.	Dioxins	177-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-150
27939992-2	2017	METHODS: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G>A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu 1 (GSTM1; Non-null/null) in 421 participants using multiple linear regression models.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	132-161
28891521-0	2017	Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat brain.	Dioxins	39-45	platelet derived growth factor receptor beta	Rattus norvegicus	101-145
28070106-1	2017	The aryl hydrocarbon receptor (AhR) avidly binds dioxin, a ubiquitous environmental contaminant.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	4-29
28070106-1	2017	The aryl hydrocarbon receptor (AhR) avidly binds dioxin, a ubiquitous environmental contaminant.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	31-34
28070106-2	2017	Disruption of downstream AhR signaling has been reported to alter neuronal development, and rodent offspring exposed to dioxin during gestation and lactation showed abnormalities in learning and memory, emotion, and social behavior.	Dioxins	120-126	aryl-hydrocarbon receptor	Mus musculus	25-28
27939992-2	2017	METHODS: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G>A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu 1 (GSTM1; Non-null/null) in 421 participants using multiple linear regression models.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	163-166
27939992-3	2017	RESULTS: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105).	Dioxins	83-89	glutathione S-transferase mu 1	Homo sapiens	33-38
27939992-4	2017	CONCLUSIONS: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy.	Dioxins	108-115	glutathione S-transferase mu 1	Homo sapiens	53-58
27503630-6	2016	Predominance of dioxin like PCBs, PCB-l14, -118 and -126 in the e-waste metal recovery sites were presumably due to combustion and pyrolytic processes performed during recycling of electrical components.	Dioxins	16-22	pyruvate carboxylase	Homo sapiens	28-31
27899901-2	2016	Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of AhR-related gene may exert pathological influences on sexual differentiation of the brain, causing autistic traits.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	33-58
27594096-1	2016	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of dioxins, but also plays important physiological roles, which are only beginning to unfold.	Dioxins	109-116	aryl hydrocarbon receptor	Rattus norvegicus	4-29
27594096-1	2016	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of dioxins, but also plays important physiological roles, which are only beginning to unfold.	Dioxins	109-116	aryl hydrocarbon receptor	Rattus norvegicus	31-34
27593435-5	2016	Dioxin-like activity was also tested in zebrafish embryos by monitoring the induction of the marker gene cyp1a.	Dioxins	0-6	cytochrome P450, family 1, subfamily A	Danio rerio	105-110
27502150-5	2016	Recently, AChE was reported as a target of the toxicity of dioxin.	Dioxins	59-65	acetylcholinesterase	Rattus norvegicus	10-14
27899901-2	2016	Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of AhR-related gene may exert pathological influences on sexual differentiation of the brain, causing autistic traits.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	60-63
27899901-2	2016	Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of AhR-related gene may exert pathological influences on sexual differentiation of the brain, causing autistic traits.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	98-101
27479457-7	2016	With respect to dioxin-like toxicity, 3-bromocarbazole, 3-chlorocarbazole, 3,6-dibromocarbazole and 3,6-dichlorocarbazoles caused induction of CYP1A1-dependent EROD activity in HII4E rat hepatoma cell line.	Dioxins	16-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	143-149
27476725-2	2016	Those able to bind the aryl hydrocarbon receptor (AhR), eliciting a plethora of toxic responses, are defined dioxin-like (DL) compounds, while the remainders are called non-DL (NDL).	Dioxins	109-115	LOC522736	Bos taurus	23-48
27476725-2	2016	Those able to bind the aryl hydrocarbon receptor (AhR), eliciting a plethora of toxic responses, are defined dioxin-like (DL) compounds, while the remainders are called non-DL (NDL).	Dioxins	109-115	LOC522736	Bos taurus	50-53
27602506-10	2016	In conclusion, this study for the first time revealed the effects of PCB-153 on development of T1D, bridging the existing experimental knowledge gap regarding the association of non-dioxin-like PCBs and T1D.	Dioxins	182-188	pyruvate carboxylase	Mus musculus	69-72
27588699-1	2016	BACKGROUND: In the risk assessment of PCDDs, PCDFs, and dioxin-like (DL) PCBs, regulatory authorities support the use of the toxic equivalency factor (TEF)-scheme derived from a heterogeneous data set of the relative effect potency (REPs) estimates.	Dioxins	56-62	TEF transcription factor, PAR bZIP family member	Homo sapiens	125-149
27588699-1	2016	BACKGROUND: In the risk assessment of PCDDs, PCDFs, and dioxin-like (DL) PCBs, regulatory authorities support the use of the toxic equivalency factor (TEF)-scheme derived from a heterogeneous data set of the relative effect potency (REPs) estimates.	Dioxins	56-62	TEF transcription factor, PAR bZIP family member	Homo sapiens	151-154
27427306-1	2016	Dioxins and dioxin-like compounds (DLCs) enter the body mainly through diet and cause various toxicological effects through activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor.	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	142-167
27713569-0	2016	Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	15-18
27713569-0	2016	Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	61-67
27713569-0	2016	Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.	Dioxins	0-6	thymine DNA glycosylase	Mus musculus	81-84
27427306-1	2016	Dioxins and dioxin-like compounds (DLCs) enter the body mainly through diet and cause various toxicological effects through activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor.	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	169-172
27427306-1	2016	Dioxins and dioxin-like compounds (DLCs) enter the body mainly through diet and cause various toxicological effects through activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor.	Dioxins	12-18	aryl hydrocarbon receptor 1a	Danio rerio	142-167
27427306-1	2016	Dioxins and dioxin-like compounds (DLCs) enter the body mainly through diet and cause various toxicological effects through activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor.	Dioxins	12-18	aryl hydrocarbon receptor 1a	Danio rerio	169-172
27427306-4	2016	In addition, there has been no report of foodstuffs that effectively prevent AhR-associated morphological abnormalities such as deformities caused by dioxins and DLCs in vivo.	Dioxins	150-157	aryl hydrocarbon receptor 1a	Danio rerio	77-80
27392949-6	2016	Transient transfection of a hairpin RNA for AhR protects against TCDD neurotoxicity, suggesting that AhR is mediating the dioxin effect.	Dioxins	122-128	aryl hydrocarbon receptor	Homo sapiens	44-47
27281544-4	2016	In this work, a computational approach was carried out to study the interactions of 41 POPs (17 PBDEs, 17 PCBs, and 7 Dioxins) with four CYP2B6 protein structures downloaded from PDB data base (PDB: 3UA5, 3QOA, 3QU8 and 4I91) using molecular docking protocols with AutoDock Vina.	Dioxins	118-125	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	137-143
27392949-6	2016	Transient transfection of a hairpin RNA for AhR protects against TCDD neurotoxicity, suggesting that AhR is mediating the dioxin effect.	Dioxins	122-128	aryl hydrocarbon receptor	Homo sapiens	101-104
26751261-1	2016	The idea of possible involvement of the aryl hydrocarbon receptor (AhR) in transplant tolerance can be traced back >30 years, when very low doses of dioxin-the most potent AhR ligand-were found to markedly reduce the generation of cytotoxic T lymphocytes in response to alloantigen challenge in vivo.	Dioxins	152-158	aryl hydrocarbon receptor	Homo sapiens	40-65
27374124-0	2016	New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins.	Dioxins	81-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
27374124-2	2016	Emerging evidence showed that in addition to classical environmental AChE inhibitors, e.g. organophosphate and carbamate pesticides, dioxins are a new type of xenobiotic causing impairment of AChE.	Dioxins	133-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
27374124-2	2016	Emerging evidence showed that in addition to classical environmental AChE inhibitors, e.g. organophosphate and carbamate pesticides, dioxins are a new type of xenobiotic causing impairment of AChE.	Dioxins	133-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196
27374124-3	2016	Dioxin can transcriptionally or post-transcriptionally suppress AChE expression in human neuroblastoma cells or mouse immune cells via the aryl hydrocarbon receptor (AhR) pathway, respectively.	Dioxins	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
27374124-3	2016	Dioxin can transcriptionally or post-transcriptionally suppress AChE expression in human neuroblastoma cells or mouse immune cells via the aryl hydrocarbon receptor (AhR) pathway, respectively.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	139-164
27374124-3	2016	Dioxin can transcriptionally or post-transcriptionally suppress AChE expression in human neuroblastoma cells or mouse immune cells via the aryl hydrocarbon receptor (AhR) pathway, respectively.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	166-169
27374124-5	2016	Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation.	Dioxins	86-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	206-210
27374124-5	2016	Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation.	Dioxins	190-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
27374124-5	2016	Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation.	Dioxins	190-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	206-210
27343407-8	2016	CYP1A induction derived by BDE-99 warrants further risk assessment as the humans, wildlife and environment are exposed to a complex mixture including dioxin-like compounds and carcinogenic compounds.	Dioxins	150-156	cytochrome P450, family 1, subfamily A	Danio rerio	0-5
27343407-8	2016	CYP1A induction derived by BDE-99 warrants further risk assessment as the humans, wildlife and environment are exposed to a complex mixture including dioxin-like compounds and carcinogenic compounds.	Dioxins	150-156	homeobox D13	Homo sapiens	27-30
26751261-1	2016	The idea of possible involvement of the aryl hydrocarbon receptor (AhR) in transplant tolerance can be traced back >30 years, when very low doses of dioxin-the most potent AhR ligand-were found to markedly reduce the generation of cytotoxic T lymphocytes in response to alloantigen challenge in vivo.	Dioxins	152-158	aryl hydrocarbon receptor	Homo sapiens	67-70
26751261-1	2016	The idea of possible involvement of the aryl hydrocarbon receptor (AhR) in transplant tolerance can be traced back >30 years, when very low doses of dioxin-the most potent AhR ligand-were found to markedly reduce the generation of cytotoxic T lymphocytes in response to alloantigen challenge in vivo.	Dioxins	152-158	aryl hydrocarbon receptor	Homo sapiens	175-178
26751261-2	2016	AhR is a ligand-activated transcription factor that is activated by dioxins and other environmental pollutants.	Dioxins	68-75	aryl hydrocarbon receptor	Homo sapiens	0-3
27176940-5	2016	The extracts were characterized with cell-based bioassays that measure dioxin-like activity (AhR-CAFLUX) and the adaptive stress response to oxidative stress (AREc32).	Dioxins	71-77	aryl hydrocarbon receptor	Homo sapiens	93-96
27178212-0	2016	In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain.	Dioxins	25-31	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	Mus musculus	49-55
26860885-1	2016	AIM: The aryl hydrocarbon receptor (AhR), a ligand-inducible transcription factor mediating toxic effects of dioxins and uremic toxins, has recently emerged as a pathophysiological regulator of immune-inflammatory conditions.	Dioxins	109-116	aryl-hydrocarbon receptor	Mus musculus	9-34
26860885-1	2016	AIM: The aryl hydrocarbon receptor (AhR), a ligand-inducible transcription factor mediating toxic effects of dioxins and uremic toxins, has recently emerged as a pathophysiological regulator of immune-inflammatory conditions.	Dioxins	109-116	aryl-hydrocarbon receptor	Mus musculus	36-39
27519288-2	2016	Hexachlorobenzene (HCB) is a dioxin-like compound that is widely distributed in the environment and is a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	124-149
27519288-2	2016	Hexachlorobenzene (HCB) is a dioxin-like compound that is widely distributed in the environment and is a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	151-154
27178212-8	2016	These results indicate that the Sema3b and Sema3g genes are sensitive to brain-specific induction by dioxin exposure, which may disrupt neural network formation in the mammalian nervous system, thereby leading to abnormal higher brain function in adulthood.	Dioxins	101-107	semaphorin 3B	Homo sapiens	32-38
27178212-8	2016	These results indicate that the Sema3b and Sema3g genes are sensitive to brain-specific induction by dioxin exposure, which may disrupt neural network formation in the mammalian nervous system, thereby leading to abnormal higher brain function in adulthood.	Dioxins	101-107	semaphorin 3G	Homo sapiens	43-49
26801687-0	2016	Toward elucidation of dioxin-mediated chloracne and Ah receptor functions.	Dioxins	22-28	aryl hydrocarbon receptor	Homo sapiens	52-63
26801687-2	2016	The dioxin TCDD accumulates in sebum, and thereby persistently activates the Ah receptor (AhR), expressed in bipotential stem/progenitor cells of the sebaceous gland.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	77-88
26801687-2	2016	The dioxin TCDD accumulates in sebum, and thereby persistently activates the Ah receptor (AhR), expressed in bipotential stem/progenitor cells of the sebaceous gland.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	90-93
27226639-7	2016	The Fgf21 promoter contains several putative dioxin response elements (DREs).	Dioxins	45-51	fibroblast growth factor 21	Mus musculus	4-9
27238841-0	2016	Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors.	Dioxins	59-65	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	121-126
27155921-5	2016	Dioxin-like pollutants can upregulate a critical enzyme responsible for TMAO formation, hepatic flavin containing monooxygenase 3 (FMO3), but a link between dioxin-like PCBs, upregulation of FMO3, and increased TMAO has not been reported.	Dioxins	0-6	flavin containing monooxygenase 3	Mus musculus	88-129
27155921-5	2016	Dioxin-like pollutants can upregulate a critical enzyme responsible for TMAO formation, hepatic flavin containing monooxygenase 3 (FMO3), but a link between dioxin-like PCBs, upregulation of FMO3, and increased TMAO has not been reported.	Dioxins	0-6	flavin containing monooxygenase 3	Mus musculus	131-135
27155921-5	2016	Dioxin-like pollutants can upregulate a critical enzyme responsible for TMAO formation, hepatic flavin containing monooxygenase 3 (FMO3), but a link between dioxin-like PCBs, upregulation of FMO3, and increased TMAO has not been reported.	Dioxins	0-6	flavin containing monooxygenase 3	Mus musculus	191-195
27155921-5	2016	Dioxin-like pollutants can upregulate a critical enzyme responsible for TMAO formation, hepatic flavin containing monooxygenase 3 (FMO3), but a link between dioxin-like PCBs, upregulation of FMO3, and increased TMAO has not been reported.	Dioxins	157-163	flavin containing monooxygenase 3	Mus musculus	191-195
27155921-6	2016	Here, we show that mice exposed acutely to dioxin-like PCBs exhibit increased hepatic FMO3 mRNA, protein, as well as an increase in circulating levels of TMAO following oral administration of its metabolic precursors.	Dioxins	43-49	flavin containing monooxygenase 3	Mus musculus	86-90
27328714-0	2016	Immuno-detection of dioxins using a recombinant protein of aryl hydrocarbon receptor (AhR) fused with sfGFP.	Dioxins	20-27	aryl hydrocarbon receptor	Homo sapiens	59-84
27131450-5	2016	The generation of dioxin-like PCBs (Co- or dl-PCB) was also analysed.	Dioxins	18-24	pyruvate carboxylase	Homo sapiens	30-33
27178212-0	2016	In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain.	Dioxins	25-31	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	Mus musculus	60-66
27328714-0	2016	Immuno-detection of dioxins using a recombinant protein of aryl hydrocarbon receptor (AhR) fused with sfGFP.	Dioxins	20-27	aryl hydrocarbon receptor	Homo sapiens	86-89
27328714-3	2016	Upon cell entry, dioxins bind specifically and firmly to the aryl hydrocarbon receptor (AhR), leading to the stimulation of several enzymes responsible for its detoxification.	Dioxins	17-24	aryl hydrocarbon receptor	Homo sapiens	61-86
27328714-3	2016	Upon cell entry, dioxins bind specifically and firmly to the aryl hydrocarbon receptor (AhR), leading to the stimulation of several enzymes responsible for its detoxification.	Dioxins	17-24	aryl hydrocarbon receptor	Homo sapiens	88-91
27283192-1	2016	The aryl hydrocarbon receptor (AHR) mediates dioxin toxicities.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	4-29
27295348-1	2016	The Aryl hydrocarbon Receptor (AhR) is a transcription factor that mediates the biochemical response to xenobiotics and the toxic effects of a number of environmental contaminants, including dioxins.	Dioxins	191-198	aryl-hydrocarbon receptor	Mus musculus	4-29
27295348-1	2016	The Aryl hydrocarbon Receptor (AhR) is a transcription factor that mediates the biochemical response to xenobiotics and the toxic effects of a number of environmental contaminants, including dioxins.	Dioxins	191-198	aryl-hydrocarbon receptor	Mus musculus	31-34
27283192-1	2016	The aryl hydrocarbon receptor (AHR) mediates dioxin toxicities.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	31-34
27067104-2	2016	Emphasis was placed on 3-hydroxymethylantipyrine (3HMAP), the metabolite with the greatest dependence on dioxin-inducible cytochrome P4501A2 (CYP1A2) activity.	Dioxins	105-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	122-140
27273260-0	2016	Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.	Dioxins	59-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	136-141
27273260-1	2016	A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities.	Dioxins	18-24	epidermal growth factor receptor	Homo sapiens	138-142
27273260-1	2016	A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities.	Dioxins	18-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-148
27038655-2	2016	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	54-79
27038655-2	2016	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	81-84
27328714-4	2016	Dioxin/AhR interaction could be exploited as an affordable alternative to a variety of analytical methods for detecting dioxin contamination in the environment.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	7-10
27328714-8	2016	Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR.	Dioxins	100-106	aryl hydrocarbon receptor	Homo sapiens	49-52
27328714-8	2016	Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR.	Dioxins	100-106	aryl hydrocarbon receptor	Homo sapiens	298-301
27328714-8	2016	Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR.	Dioxins	223-229	aryl hydrocarbon receptor	Homo sapiens	49-52
27328714-8	2016	Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR.	Dioxins	223-229	aryl hydrocarbon receptor	Homo sapiens	49-52
27328714-9	2016	Nevertheless,the detection range of sfGFP-AhR fusion was much wider and the detection limit was of about 10 ppt (parts per trillion) of free dioxin in the tested artificial samples.	Dioxins	141-147	aryl hydrocarbon receptor	Homo sapiens	42-45
27328714-10	2016	CONCLUSIONS: this highly expressed and functional sfGFP-AhR fusion protein provides a promising molecular tool for detecting and quantifying different congeners of dioxins.	Dioxins	164-171	aryl hydrocarbon receptor	Homo sapiens	56-59
27067104-2	2016	Emphasis was placed on 3-hydroxymethylantipyrine (3HMAP), the metabolite with the greatest dependence on dioxin-inducible cytochrome P4501A2 (CYP1A2) activity.	Dioxins	105-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
27197834-6	2016	These results suggest that the retarded development of interneurons by the excessive AhR signaling may at least in part explain the dioxin-induced abnormal behavioral alterations previously reported in laboratory animals.	Dioxins	132-138	aryl-hydrocarbon receptor	Mus musculus	85-88
27210033-6	2016	Notably, excess Se exposure up-regulated transcript abundance of aryl hydrocarbon receptor 2 (ahr2), a signalling pathway involved in the toxicity of dioxin-related compounds.	Dioxins	150-156	aryl hydrocarbon receptor 2	Danio rerio	65-92
27210033-6	2016	Notably, excess Se exposure up-regulated transcript abundance of aryl hydrocarbon receptor 2 (ahr2), a signalling pathway involved in the toxicity of dioxin-related compounds.	Dioxins	150-156	aryl hydrocarbon receptor 2	Danio rerio	94-98
26970589-3	2016	OBJECTIVES: The aim was to examine the association between maternal low level dietary exposure to dioxins and PCB during pregnancy and language development in 3year old children in a large group of mother-child pairs participating in the Norwegian Mother and Child Cohort Study (MoBa).	Dioxins	98-105	pyruvate carboxylase	Homo sapiens	110-113
26987414-8	2016	However, 2-hydroxyfluorene and 3-hydroxyfluorene exerted significant estrogenic and dioxin-like activity on a concentration range of 3-30 muM, while fluorene and 9-hydroxyfluorene were weakly or not active, respectively, in our assays.	Dioxins	84-90	latexin	Homo sapiens	138-141
26758301-0	2016	Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men.	Dioxins	13-19	kallikrein related peptidase 3	Homo sapiens	44-69
26820928-7	2016	Highly chlorinated dioxin congeners, such as octacholorodibenzodioxin (OCDD), 1,2,3,4,6,7,8-heptacholorodibenzodioxin (HpCDD) and 1,2,3,4 (or 6), 7,8-hexachlorodibenzodioxin Hx(CDD), showed stronger inverse associations with the children"s salivary DHEA than other lowly chlorinated dioxin congeners.	Dioxins	19-25	natriuretic peptide A	Homo sapiens	72-75
26758301-2	2016	There have been few studies focusing on the relationship between levels of prostate-specific antigen (PSA) and dioxins or steroid hormones in Vietnamese men.	Dioxins	111-118	kallikrein related peptidase 3	Homo sapiens	75-106
26564202-0	2016	An AhR-Luciferase Adenovirus Infection System for Rapid Screening of Dioxins in Soils.	Dioxins	69-76	aryl hydrocarbon receptor	Homo sapiens	3-6
26936477-8	2016	In conclusion, our study shows for the first time that exposure to a dioxin-like PCB adversely affects skeletal muscle glucose metabolism.	Dioxins	69-75	pyruvate carboxylase	Homo sapiens	81-84
27008165-8	2016	The anti-apoptotic process found in the GCs of women fromTaranto was associated with the highest levels of progesterone receptor membrane component 1 (PGRMC1), a novel progesterone receptor, the expression of which is subjected to AHR activated by its highest affinity ligands (e.g., dioxins) or indirectly by other environmental pollutants, such as heavy metals.	Dioxins	284-291	progesterone receptor membrane component 1	Homo sapiens	107-149
27008165-8	2016	The anti-apoptotic process found in the GCs of women fromTaranto was associated with the highest levels of progesterone receptor membrane component 1 (PGRMC1), a novel progesterone receptor, the expression of which is subjected to AHR activated by its highest affinity ligands (e.g., dioxins) or indirectly by other environmental pollutants, such as heavy metals.	Dioxins	284-291	progesterone receptor membrane component 1	Homo sapiens	151-157
27008165-8	2016	The anti-apoptotic process found in the GCs of women fromTaranto was associated with the highest levels of progesterone receptor membrane component 1 (PGRMC1), a novel progesterone receptor, the expression of which is subjected to AHR activated by its highest affinity ligands (e.g., dioxins) or indirectly by other environmental pollutants, such as heavy metals.	Dioxins	284-291	aryl hydrocarbon receptor	Homo sapiens	231-234
26970589-6	2016	Exposure to dioxins and dioxin-like PCBs (dl-compounds) was expressed in total toxic equivalents (TEQ), and PCB-153 was used as marker for non-dioxin-like PCBs (ndlPCBs).	Dioxins	24-30	pyruvate carboxylase	Homo sapiens	36-39
26692507-4	2016	All sediment samples tested positive for dioxin-like activity with total activity ranging from 16 to 37 pg toxic equivalents (TEQ) g(-1) dry weight (dw) for the Jukskei River catchment and 1.5-22 pg TEQ g(-1) dw for the Klip/Vaal River catchment, indicating that the Jukskei River catchment area had higher concentrations of total dioxin-like compounds.	Dioxins	41-47	TNFAIP3 interacting protein 2	Homo sapiens	220-224
26490912-1	2016	Dioxin-like polychlorinated biphenyl (dl-PCB) concentrations in ambient air and soil in Shanghai, China, were measured to allow seasonal and spatial differences in the dl-PCB concentrations, profiles, distributions, fugacity fractions, and air-soil fluxes to be determined.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	41-44
26006071-0	2016	Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3.	Dioxins	22-28	paraoxonase 1	Rattus norvegicus	108-125
25099626-0	2016	Developmental toxicity, EROD, and CYP1A mRNA expression in zebrafish embryos exposed to dioxin-like PCB126.	Dioxins	88-94	cytochrome P450, family 1, subfamily A	Danio rerio	34-39
25099626-2	2016	Dioxins have a high affinity for aryl hydrocarbon receptor (AhR) and induce cytochrome P4501A (CYP1A).	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	33-58
25099626-2	2016	Dioxins have a high affinity for aryl hydrocarbon receptor (AhR) and induce cytochrome P4501A (CYP1A).	Dioxins	0-7	aryl hydrocarbon receptor 1a	Danio rerio	60-63
25099626-2	2016	Dioxins have a high affinity for aryl hydrocarbon receptor (AhR) and induce cytochrome P4501A (CYP1A).	Dioxins	0-7	cytochrome P450, family 1, subfamily A	Danio rerio	76-93
25099626-2	2016	Dioxins have a high affinity for aryl hydrocarbon receptor (AhR) and induce cytochrome P4501A (CYP1A).	Dioxins	0-7	cytochrome P450, family 1, subfamily A	Danio rerio	95-100
26006071-0	2016	Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3.	Dioxins	42-48	paraoxonase 1	Rattus norvegicus	108-125
26077315-0	2016	Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells.	Dioxins	9-15	aryl hydrocarbon receptor	Rattus norvegicus	57-60
25893464-4	2016	The sum of median concentrations of tri + tetra-chlorinated PCB was almost ten times higher in the exposed group than in the unexposed, and sums of dioxin-like and non-dioxin-like PCB were both relatively increased by 60 % in the exposed group.	Dioxins	168-174	pyruvate carboxylase	Homo sapiens	180-183
26572662-2	2016	Genome-wide expression profiling during differentiation of mouse ES cells into cardiomyocytes showed that AHR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin; Dioxin (TCDD), its prototypical ligand, disrupted the expression of multiple homeobox transcription factors and inhibited cardiomyocyte contractility.	Dioxins	161-167	aryl-hydrocarbon receptor	Mus musculus	106-109
26752053-0	2016	Abdominal Obesity and Insulin Resistance in People Exposed to Moderate-to-High Levels of Dioxin.	Dioxins	89-95	insulin	Homo sapiens	22-29
26752053-4	2016	We aimed to examine whether insulin resistance is greater in people with abdominal obesity (AO) and concomitant exposure to serum dioxins (PCDD/Fs).	Dioxins	130-137	insulin	Homo sapiens	28-35
26530806-2	2016	AhR activation is of immunological importance, but at the same time mediates toxicity of environmental pollutants, such as immunosuppression by dioxins.	Dioxins	144-151	aryl hydrocarbon receptor	Homo sapiens	0-3
26616910-2	2016	The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway.	Dioxins	52-58	aryl hydrocarbon receptor 1a	Danio rerio	97-122
26616910-2	2016	The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway.	Dioxins	52-58	aryl hydrocarbon receptor 1a	Danio rerio	124-127
26770886-2	2016	Rodent studies have shown that exposure to PCB126, a dioxin-like PCB, causes a significant disruption of hepatic micronutrient homeostasis and an increase in metallothionein (MT), an antioxidant protein and metal carrier.	Dioxins	53-59	pyruvate carboxylase	Mus musculus	43-46
32288929-7	2016	As a result, with active involvements and contribution of the MEP, local governments, enterprises, experts and monitoring instructions, the incentive plan vigorously guided and promoted BAT/BEP replication and application for medical waste disposal, avoided and reduced the generation and emission of dioxin POPs and other toxic substances.	Dioxins	301-307	neurolysin	Homo sapiens	62-65
27829840-4	2016	It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR.	Dioxins	87-94	aryl hydrocarbon receptor	Homo sapiens	165-168
25867062-2	2015	The AhR is widely known as a mediator of dioxin toxicity; however, it also suppresses cancer cell proliferation and recent findings have implicated its role as a tumor suppressor.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	4-7
26558458-1	2015	Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	94-101	aryl hydrocarbon receptor	Homo sapiens	0-25
26417045-4	2015	Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phase 1 enzymes are well studied in rodent lung, liver, and other organs, the toxicity profiles limit their use as therapeutic agents in humans.	Dioxins	81-88	aryl hydrocarbon receptor	Homo sapiens	36-39
26408075-0	2015	The aryl hydrocarbon receptor suppresses cigarette-smoke-induced oxidative stress in association with dioxin response element (DRE)-independent regulation of sulfiredoxin 1.	Dioxins	102-108	aryl hydrocarbon receptor	Homo sapiens	4-29
26558458-1	2015	Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	94-101	aryl hydrocarbon receptor	Homo sapiens	27-30
26037956-2	2015	Both groups of PAHs have been reported to cause dioxin-like responses, mediated by aryl hydrocarbon receptor (AhR).	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	83-108
26348139-1	2015	Prenatal exposure to endocrine disrupting chemicals (EDCs), including bisphenol A, dioxin, pesticides, and cigarette smoke, has been linked to several ovarian diseases such as premature ovarian failure (POF) and early menopause in women.	Dioxins	83-89	POF1B actin binding protein	Homo sapiens	203-206
26037956-2	2015	Both groups of PAHs have been reported to cause dioxin-like responses, mediated by aryl hydrocarbon receptor (AhR).	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	110-113
26276439-1	2015	Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	0-25
26276439-1	2015	Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	27-30
26448361-3	2015	It is based on the aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 enzymes (subfamily 1A) in cells after exposure to dioxins and dioxin-like compounds.	Dioxins	139-146	aryl hydrocarbon receptor	Rattus norvegicus	19-44
26448361-3	2015	It is based on the aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 enzymes (subfamily 1A) in cells after exposure to dioxins and dioxin-like compounds.	Dioxins	139-146	aryl hydrocarbon receptor	Rattus norvegicus	46-49
26448361-3	2015	It is based on the aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 enzymes (subfamily 1A) in cells after exposure to dioxins and dioxin-like compounds.	Dioxins	139-145	aryl hydrocarbon receptor	Rattus norvegicus	19-44
26448361-3	2015	It is based on the aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 enzymes (subfamily 1A) in cells after exposure to dioxins and dioxin-like compounds.	Dioxins	139-145	aryl hydrocarbon receptor	Rattus norvegicus	46-49
26259605-4	2015	A survey of promoter regions of chemokine genes revealed that there are several putative dioxin responsive elements in the mouse Ccl20 promoter.	Dioxins	89-95	chemokine (C-C motif) ligand 20	Mus musculus	129-134
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	Dioxins	195-201	aryl hydrocarbon receptor	Homo sapiens	62-65
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	Dioxins	195-201	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	Dioxins	205-211	aryl hydrocarbon receptor	Homo sapiens	62-65
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	Dioxins	205-211	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
26392334-1	2015	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin.	Dioxins	136-142	aryl hydrocarbon receptor	Homo sapiens	4-29
26392334-1	2015	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin.	Dioxins	136-142	aryl hydrocarbon receptor	Homo sapiens	31-34
26041783-4	2015	High-affinity ligands of AHR have been classically defined as xenobiotics, such as polychlorinated biphenyls and dioxins.	Dioxins	113-120	aryl hydrocarbon receptor	Homo sapiens	25-28
26366531-1	2015	The Ah receptor (AhR)-responsive CALUX (chemically activated luciferase expression) cell bioassay is commonly used for rapid screening of samples for the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), dioxin-like compounds, and AhR agonists/antagonists.	Dioxins	195-201	aryl-hydrocarbon receptor	Mus musculus	4-15
26366531-1	2015	The Ah receptor (AhR)-responsive CALUX (chemically activated luciferase expression) cell bioassay is commonly used for rapid screening of samples for the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), dioxin-like compounds, and AhR agonists/antagonists.	Dioxins	195-201	aryl-hydrocarbon receptor	Mus musculus	17-20
26366531-1	2015	The Ah receptor (AhR)-responsive CALUX (chemically activated luciferase expression) cell bioassay is commonly used for rapid screening of samples for the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), dioxin-like compounds, and AhR agonists/antagonists.	Dioxins	209-215	aryl-hydrocarbon receptor	Mus musculus	4-15
26366531-1	2015	The Ah receptor (AhR)-responsive CALUX (chemically activated luciferase expression) cell bioassay is commonly used for rapid screening of samples for the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), dioxin-like compounds, and AhR agonists/antagonists.	Dioxins	209-215	aryl-hydrocarbon receptor	Mus musculus	17-20
26366531-2	2015	By increasing the number of AhR DNA recognition sites (dioxin responsive elements), we previously generated a novel third generation (G3) recombinant AhR-responsive mouse CALUX cell line (H1L7.5c3) with a significantly enhanced response to DLCs compared to existing AhR-CALUX cell bioassays.	Dioxins	55-61	aryl-hydrocarbon receptor	Mus musculus	28-31
26366531-2	2015	By increasing the number of AhR DNA recognition sites (dioxin responsive elements), we previously generated a novel third generation (G3) recombinant AhR-responsive mouse CALUX cell line (H1L7.5c3) with a significantly enhanced response to DLCs compared to existing AhR-CALUX cell bioassays.	Dioxins	55-61	aryl-hydrocarbon receptor	Mus musculus	150-153
26366531-2	2015	By increasing the number of AhR DNA recognition sites (dioxin responsive elements), we previously generated a novel third generation (G3) recombinant AhR-responsive mouse CALUX cell line (H1L7.5c3) with a significantly enhanced response to DLCs compared to existing AhR-CALUX cell bioassays.	Dioxins	55-61	aryl-hydrocarbon receptor	Mus musculus	150-153
26215100-1	2015	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	4-29
26215100-1	2015	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	31-34
25786502-1	2015	BACKGROUND: The aryl hydrocarbon receptor (AhR) recognizes diverse small molecules such as dioxins, tryptophan photoproducts and phytochemicals.	Dioxins	91-98	aryl hydrocarbon receptor	Homo sapiens	16-41
25786502-1	2015	BACKGROUND: The aryl hydrocarbon receptor (AhR) recognizes diverse small molecules such as dioxins, tryptophan photoproducts and phytochemicals.	Dioxins	91-98	aryl hydrocarbon receptor	Homo sapiens	43-46
26226543-7	2015	The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	178-184	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43
26010306-7	2015	Additionally, we summarized basic studies carried out by the Yusho Group to re-evaluate the mechanisms of dioxin toxicities in experimental models and various functions of the aryl hydrocarbon receptor (AhR), known as the dioxin receptor, pathway.	Dioxins	106-112	aryl hydrocarbon receptor	Homo sapiens	203-206
26226543-7	2015	The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	178-184	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	48-54
26079192-1	2015	The aryl hydrocarbon receptor (AhR) is a highly evolutionary conserved, ligand-activated transcription factor that is best known to mediate the toxicities of dioxins and dioxin-like compounds.	Dioxins	158-165	aryl-hydrocarbon receptor	Mus musculus	4-29
26997841-1	2015	CYP1B1 is a dioxin-inducible enzyme belonging to the cytochrome P450 superfamily.	Dioxins	12-18	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
26561251-3	2015	Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins.	Dioxins	187-194	aryl hydrocarbon receptor	Homo sapiens	0-25
26561251-3	2015	Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins.	Dioxins	187-194	aryl hydrocarbon receptor	Homo sapiens	27-30
26145830-3	2015	Dioxins and DLCs are potent aryl hydrocarbon receptor (AHR) ligands that cause a range of species-specific adverse outcomes.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	28-53
26145830-3	2015	Dioxins and DLCs are potent aryl hydrocarbon receptor (AHR) ligands that cause a range of species-specific adverse outcomes.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	55-58
26109068-5	2015	Dioxin exposure, acting through the aryl hydrocarbon receptor (AHR), blocked eyelid closure in genetic mutants in which MAP3K1 signaling was attenuated but did not disturb this developmental program in either wild type or mutant mice with attenuated epidermal growth factor receptor or WNT signaling.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	36-61
26109068-5	2015	Dioxin exposure, acting through the aryl hydrocarbon receptor (AHR), blocked eyelid closure in genetic mutants in which MAP3K1 signaling was attenuated but did not disturb this developmental program in either wild type or mutant mice with attenuated epidermal growth factor receptor or WNT signaling.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	63-66
26109068-5	2015	Dioxin exposure, acting through the aryl hydrocarbon receptor (AHR), blocked eyelid closure in genetic mutants in which MAP3K1 signaling was attenuated but did not disturb this developmental program in either wild type or mutant mice with attenuated epidermal growth factor receptor or WNT signaling.	Dioxins	0-6	mitogen-activated protein kinase kinase kinase 1	Mus musculus	120-126
26109068-5	2015	Dioxin exposure, acting through the aryl hydrocarbon receptor (AHR), blocked eyelid closure in genetic mutants in which MAP3K1 signaling was attenuated but did not disturb this developmental program in either wild type or mutant mice with attenuated epidermal growth factor receptor or WNT signaling.	Dioxins	0-6	epidermal growth factor receptor	Mus musculus	250-282
26109068-6	2015	Exposure also markedly inhibited c-Jun phosphorylation in Map3k1(+/-) embryonic eyelid epithelium, suggesting that dioxin-induced AHR pathways can synergize with gene mutations to inhibit MAP3K1 signaling.	Dioxins	115-121	jun proto-oncogene	Mus musculus	33-38
26109068-6	2015	Exposure also markedly inhibited c-Jun phosphorylation in Map3k1(+/-) embryonic eyelid epithelium, suggesting that dioxin-induced AHR pathways can synergize with gene mutations to inhibit MAP3K1 signaling.	Dioxins	115-121	mitogen-activated protein kinase kinase kinase 1	Mus musculus	58-64
26109068-6	2015	Exposure also markedly inhibited c-Jun phosphorylation in Map3k1(+/-) embryonic eyelid epithelium, suggesting that dioxin-induced AHR pathways can synergize with gene mutations to inhibit MAP3K1 signaling.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	130-133
26109068-6	2015	Exposure also markedly inhibited c-Jun phosphorylation in Map3k1(+/-) embryonic eyelid epithelium, suggesting that dioxin-induced AHR pathways can synergize with gene mutations to inhibit MAP3K1 signaling.	Dioxins	115-121	mitogen-activated protein kinase kinase kinase 1	Mus musculus	188-194
26079192-1	2015	The aryl hydrocarbon receptor (AhR) is a highly evolutionary conserved, ligand-activated transcription factor that is best known to mediate the toxicities of dioxins and dioxin-like compounds.	Dioxins	158-165	aryl-hydrocarbon receptor	Mus musculus	31-34
26079192-1	2015	The aryl hydrocarbon receptor (AhR) is a highly evolutionary conserved, ligand-activated transcription factor that is best known to mediate the toxicities of dioxins and dioxin-like compounds.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	4-29
26079192-1	2015	The aryl hydrocarbon receptor (AhR) is a highly evolutionary conserved, ligand-activated transcription factor that is best known to mediate the toxicities of dioxins and dioxin-like compounds.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	31-34
25975270-0	2015	Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.	Dioxins	74-80	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	41-47
25929522-6	2015	Mycophenolate mofetil antagonized the effects of dexamethasone on GR but it potentiated the action of dioxin on AhR.	Dioxins	102-108	aryl hydrocarbon receptor	Homo sapiens	112-115
25929522-7	2015	Induction of CYP1A1 mRNA in HepG2 cells by dioxin was modestly antagonized by mycophenolate mofetil, while the induction by benzo[a]pyren or S-omeprazole was significantly potentiated by this drug.	Dioxins	43-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
25975270-1	2015	The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD).	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	4-29
25975270-1	2015	The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD).	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	31-34
25975270-3	2015	Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	31-73
25975270-3	2015	Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	75-81
25975270-3	2015	Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality.	Dioxins	154-160	aryl-hydrocarbon receptor	Mus musculus	114-117
25975270-4	2015	Tiparp(-/-) mice given a single injection of 100 mug/kg dioxin did not survive beyond day 5; all Tiparp(+/+) mice survived the 30-day treatment.	Dioxins	56-62	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	0-6
25975270-5	2015	Dioxin-treated Tiparp(-/-) mice exhibited increased liver steatosis and hepatotoxicity.	Dioxins	0-6	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	15-21
25975270-7	2015	These results reveal previously unidentified roles for Tiparp, MacroD1, and ADP-ribosylation in AHR-mediated steatohepatitis and lethality in response to dioxin.	Dioxins	154-160	TCDD-inducible poly(ADP-ribose) polymerase	Mus musculus	55-61
25975270-7	2015	These results reveal previously unidentified roles for Tiparp, MacroD1, and ADP-ribosylation in AHR-mediated steatohepatitis and lethality in response to dioxin.	Dioxins	154-160	aryl-hydrocarbon receptor	Mus musculus	96-99
26085534-4	2015	We hypothesized that activation of the Ahr by dioxin would inhibit bone morphogenetic protein (BMP)-2-mediated spinal fusion in a rat arthrodesis model.	Dioxins	46-52	aryl hydrocarbon receptor	Rattus norvegicus	39-42
26085534-4	2015	We hypothesized that activation of the Ahr by dioxin would inhibit bone morphogenetic protein (BMP)-2-mediated spinal fusion in a rat arthrodesis model.	Dioxins	46-52	bone morphogenetic protein 1	Homo sapiens	95-98
26085534-14	2015	Since dioxin and other similar cigarette smoke toxins exert their effects through Ahr pathway activation, the receptor represents a potential therapeutic target to improve spinal fusion rates in patients who smoke.	Dioxins	6-12	aryl hydrocarbon receptor	Homo sapiens	82-85
26085540-2	2015	: "Dioxin Exposure Impairs BMP-2-Mediated Spinal Fusion in a Rat Arthrodesis Model".	Dioxins	3-9	bone morphogenetic protein 2	Rattus norvegicus	27-32
25385058-1	2015	AIMS: Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor.	Dioxins	6-12	aryl hydrocarbon receptor	Homo sapiens	57-82
25385058-1	2015	AIMS: Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor.	Dioxins	6-12	aryl hydrocarbon receptor	Homo sapiens	84-87
25385058-1	2015	AIMS: Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor.	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	57-82
25385058-1	2015	AIMS: Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor.	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	84-87
25532870-1	2015	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs).	Dioxins	122-128	aryl hydrocarbon receptor 1a	Danio rerio	4-29
25532870-1	2015	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs).	Dioxins	122-128	aryl hydrocarbon receptor 1a	Danio rerio	31-34
25972192-10	2015	These findings suggest that the level of in utero exposure to PCBs and dioxins may affect serum concentrations of growth hormone, thyroid hormones, TBG, and IGFBP-3 in 8-year-old children.	Dioxins	71-78	growth hormone 1	Homo sapiens	114-128
25972192-0	2015	Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls.	Dioxins	85-92	growth hormone 1	Homo sapiens	12-26
25659934-0	2015	Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.	Dioxins	4-10	pyruvate carboxylase	Homo sapiens	43-46
25659934-0	2015	Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.	Dioxins	4-10	pyruvate carboxylase	Homo sapiens	52-55
25659934-0	2015	Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.	Dioxins	4-10	pyruvate carboxylase	Homo sapiens	52-55
26226672-1	2015	Dioxin and dioxin-like compounds receptor (Ahr) mainly expressed on the surface of regulatory T (Treg) cell and Th17 cell could regulate immunological functions in the Yusho patients.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	43-46
26226675-0	2015	[Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients].	Dioxins	37-44	aryl hydrocarbon receptor	Homo sapiens	57-60
26226682-5	2015	We describe here the latest research findings of chronic dioxin-induced toxicity to Yusho patients and the mechanisms of toxicities of dioxins through the aryl hydrocarbon receptor (AhR) pathway.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	182-185
26226682-5	2015	We describe here the latest research findings of chronic dioxin-induced toxicity to Yusho patients and the mechanisms of toxicities of dioxins through the aryl hydrocarbon receptor (AhR) pathway.	Dioxins	135-142	aryl hydrocarbon receptor	Homo sapiens	155-180
26226682-5	2015	We describe here the latest research findings of chronic dioxin-induced toxicity to Yusho patients and the mechanisms of toxicities of dioxins through the aryl hydrocarbon receptor (AhR) pathway.	Dioxins	135-142	aryl hydrocarbon receptor	Homo sapiens	182-185
25711857-2	2015	The aryl hydrocarbon receptor (AHR) is well-known to mediate developmental toxicity of persistent dioxin-like compounds (DLCs).	Dioxins	98-104	aryl hydrocarbon receptor 1a	Danio rerio	4-29
25711857-2	2015	The aryl hydrocarbon receptor (AHR) is well-known to mediate developmental toxicity of persistent dioxin-like compounds (DLCs).	Dioxins	98-104	aryl hydrocarbon receptor 1a	Danio rerio	31-34
25711857-5	2015	We observed that zebrafish embryos exposed to the beta-catenin inhibitor XAV939 display effects phenocopying those of the dioxin-like 3,3",4,4",5-pentachlorobiphenyl (PCB126).	Dioxins	122-128	catenin (cadherin-associated protein), beta 1	Danio rerio	50-62
25867478-2	2015	We conducted this study to rule out if dioxin may directly target the growth plate, via local modulation of the aryl hydrocarbon receptor (AhR).	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	112-137
25867478-2	2015	We conducted this study to rule out if dioxin may directly target the growth plate, via local modulation of the aryl hydrocarbon receptor (AhR).	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	139-142
25867478-8	2015	We conclude that although the AhR is widely expressed in the growth plate, bone growth is not modulated when locally activated, and therefore, dioxin-induced growth failure is likely mediated through systemic rather than local actions.	Dioxins	143-149	aryl hydrocarbon receptor	Homo sapiens	30-33
25861343-0	2015	Regulation of CYP1A1 and Inflammatory Cytokine by NCOA7 Isoform 4 in Response to Dioxin Induced Airway Inflammation.	Dioxins	81-87	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
25861343-0	2015	Regulation of CYP1A1 and Inflammatory Cytokine by NCOA7 Isoform 4 in Response to Dioxin Induced Airway Inflammation.	Dioxins	81-87	nuclear receptor coactivator 7	Homo sapiens	50-55
25972192-10	2015	These findings suggest that the level of in utero exposure to PCBs and dioxins may affect serum concentrations of growth hormone, thyroid hormones, TBG, and IGFBP-3 in 8-year-old children.	Dioxins	71-78	serpin family A member 7	Homo sapiens	148-151
25972192-10	2015	These findings suggest that the level of in utero exposure to PCBs and dioxins may affect serum concentrations of growth hormone, thyroid hormones, TBG, and IGFBP-3 in 8-year-old children.	Dioxins	71-78	insulin like growth factor binding protein 3	Homo sapiens	157-164
24555447-5	2015	CONCLUSIONS: Downregulated Wnt5a and lymphoid enhancing-binding factor 1 are associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cleft palate.	Dioxins	122-128	wingless-type MMTV integration site family, member 5A	Mus musculus	27-32
25692546-1	2015	The aryl hydrocarbon receptor (AHR) mediates toxic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds (DLCs).	Dioxins	93-99	aryl hydrocarbon receptor 1 alpha	Gallus gallus	4-29
25692546-1	2015	The aryl hydrocarbon receptor (AHR) mediates toxic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds (DLCs).	Dioxins	93-99	aryl hydrocarbon receptor 1 alpha	Gallus gallus	31-34
25522853-3	2015	The present study investigated burden of composts and digestates collected in 16 European countries (88 samples) by the compounds causing dioxin-like effects as determined by use of an in vitro transactivation assay to quantify total concentrations of aryl hydrocarbon receptor-(AhR) mediated potency.	Dioxins	138-144	aryl hydrocarbon receptor	Homo sapiens	279-282
25540854-0	2015	Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.	Dioxins	66-73	aryl hydrocarbon receptor	Homo sapiens	137-162
25540854-1	2015	The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls.	Dioxins	82-89	aryl hydrocarbon receptor	Homo sapiens	4-29
25540854-1	2015	The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls.	Dioxins	82-89	aryl hydrocarbon receptor	Homo sapiens	31-34
25304490-4	2015	PCB126 is a dioxin-like PCB and a potent aryl hydrocarbon receptor (AhR) agonist.	Dioxins	12-18	pyruvate carboxylase	Homo sapiens	0-3
25646150-7	2015	We identified pollutants associated with mammary cancer belonging to the dioxin like-PCB family (notably PCB-118, -156, -105, -114) that were already pointed out in human epidemiological studies on breast cancer, and that fit with the fundamental role of the Aryl Hydrocarbon Receptor in the promotion of breast cancer.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	259-284
25440895-5	2015	The toxicological significance of the pollutants was assessed using the toxic equivalency factor (TEF) to calculate both the toxic equivalent for dioxins (TEQTCDD) and the TEQ carcinogenic risks.	Dioxins	146-153	TEF transcription factor, PAR bZIP family member	Homo sapiens	98-101
25179274-2	2015	It is often found in surface waters in both the acidic (HTric) and basic (Tric(-)) forms (pKa ~8), and it can undergo direct photodegradation to produce several intermediates including a dioxin congener (2,8-dichlorodibenzodioxin, hereafter 28DCDD).	Dioxins	187-193	MARVEL domain containing 2	Homo sapiens	57-61
25179274-7	2015	In the case of Tric(-) the direct photolysis is much more important than for HTric, but triplet-sensitised transformation could produce 28DCDD + 27DCDD with higher yield compared to the direct photolysis, and it could play some role as dioxin source in deep waters with elevated DOC.	Dioxins	236-242	MARVEL domain containing 2	Homo sapiens	15-19
25668756-2	2015	In general, dioxin-like polychlorinated biphenyls (PCBs) exhibit a ligand-dependent activation of AhR-signaling.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	98-101
25668756-3	2015	Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling.	Dioxins	111-117	pyruvate carboxylase	Homo sapiens	123-126
25668756-3	2015	Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling.	Dioxins	111-117	pyruvate carboxylase	Homo sapiens	128-132
25668756-3	2015	Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling.	Dioxins	111-117	aryl hydrocarbon receptor	Homo sapiens	149-152
25668756-4	2015	Treatments of HaCaT human keratinocytes with 4-ClBQ and dioxin-like PCB126 significantly increased AhR-target gene expression, CYP1A1 mRNA and protein levels.	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	99-102
25668756-4	2015	Treatments of HaCaT human keratinocytes with 4-ClBQ and dioxin-like PCB126 significantly increased AhR-target gene expression, CYP1A1 mRNA and protein levels.	Dioxins	56-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-133
25849111-10	2015	A significant decrease in risk of estrogen receptor negative (ER-)/progesterone receptor negative (PR-) tumors was observed among post-menopausal women in the upper quartile of estimated dioxin intake (HR for Q4 vs. Q1: 0.65; 95% CI: 0.45, 0.96; P for trend across quartiles = 0.0463).	Dioxins	187-193	progesterone receptor	Homo sapiens	67-88
25663396-0	2015	Dioxin-like PCB levels in maternal and umbilical cord sera of people living near dump sites in southern Italy: a pilot study of biomonitoring.	Dioxins	0-6	pyruvate carboxylase	Homo sapiens	12-15
25553538-6	2015	In mammals, some non-dioxin-like PCB congeners act through nuclear receptor 1I2, the pregnane-X-receptor (PXR).	Dioxins	21-27	nuclear receptor subfamily 1 group I member 2	Fundulus heteroclitus	85-104
25553538-6	2015	In mammals, some non-dioxin-like PCB congeners act through nuclear receptor 1I2, the pregnane-X-receptor (PXR).	Dioxins	21-27	nuclear receptor subfamily 1 group I member 2	Fundulus heteroclitus	106-109
25445724-0	2015	Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.	Dioxins	55-62	aryl hydrocarbon receptor	Homo sapiens	0-25
25445724-0	2015	Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.	Dioxins	55-62	interleukin 24	Homo sapiens	154-168
25445724-1	2015	Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	171-196
25445724-1	2015	Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	198-201
25445724-2	2015	Genetic variation in AhR may modulate the susceptibility to dioxins.	Dioxins	60-67	aryl hydrocarbon receptor	Homo sapiens	21-24
25445724-3	2015	In this study, we aimed to evaluate the effects of the single nucleotide polymorphism (SNP) -130 C/T in the AhR promoter on dioxin-inducible gene transcription, and to investigate interleukin-24 (IL-24) and interleukin-1beta (IL-1beta) as proxies for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.	Dioxins	124-130	aryl hydrocarbon receptor	Homo sapiens	108-111
25445724-11	2015	Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1beta, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.	Dioxins	191-198	aryl hydrocarbon receptor	Homo sapiens	57-60
25445724-11	2015	Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1beta, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.	Dioxins	191-198	interleukin 24	Homo sapiens	97-102
25445724-11	2015	Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1beta, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.	Dioxins	191-198	interleukin 1 beta	Homo sapiens	107-115
25445724-11	2015	Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1beta, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.	Dioxins	191-198	aryl hydrocarbon receptor	Homo sapiens	147-150
25383696-7	2015	We found the AhR ligand activities of the above four BUVSs to be stable in the presence of CYP1A1; therefore, they have the potential to accumulate and exert potent physiological effects in humans, analogous to polycyclic aromatic hydrocarbons and dioxins, which are known stable and toxic ligands.	Dioxins	248-255	aryl hydrocarbon receptor	Homo sapiens	13-16
25251150-0	2015	Constitutive expression of the AHR signaling pathway in a bovine mammary epithelial cell line and modulation by dioxin-like PCB and other AHR ligands.	Dioxins	112-118	LOC522736	Bos taurus	31-34
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Dioxins	34-40	LOC522736	Bos taurus	101-126
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Dioxins	34-40	LOC522736	Bos taurus	128-131
25112208-0	2015	High-throughput method of dioxin analysis in aqueous samples using consecutive solid phase extraction steps with the new C18 Ultraflow  pressurized liquid extraction and automated clean-up.	Dioxins	26-32	Bardet-Biedl syndrome 9	Homo sapiens	121-124
26440531-4	2015	Expression of CYP1A1 in human skin is a key marker for AhR activation, and it may induce comedogenesis resulting in acne-like lesions known as chloracne/metabolising acquired dioxin-induced skin hamartomas (MADISH).	Dioxins	175-181	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
26440531-4	2015	Expression of CYP1A1 in human skin is a key marker for AhR activation, and it may induce comedogenesis resulting in acne-like lesions known as chloracne/metabolising acquired dioxin-induced skin hamartomas (MADISH).	Dioxins	175-181	aryl hydrocarbon receptor	Homo sapiens	55-58
26440531-6	2015	MATERIALS AND METHODS: We explored the expression of CYP1A1 by immunohistochemistry in the acne lesions of 16 patients living in the region of Naples, Italy, where epidemiological studies have suggested a possibly increased exposure to environmental dioxins.	Dioxins	250-257	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
25087452-0	2015	Public health assessment of dioxin-contaminated fish at former US airbase, Bien Hoa, Vietnam.	Dioxins	28-34	matrilin 3	Homo sapiens	80-83
25265996-0	2015	Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.	Dioxins	0-6	aryl hydrocarbon receptor repressor	Homo sapiens	101-136
24966027-1	2014	Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites.	Dioxins	164-171	aryl hydrocarbon receptor	Homo sapiens	0-25
26567990-0	2015	Different regulation of aryl hydrocarbon receptor-regulated genes in response to dioxin in undifferentiated and neuronally differentiated human neuroblastoma SH-SY5Y cells.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	24-49
25209921-0	2014	Amino acid sequence of the AhR1 ligand-binding domain predicts avian sensitivity to dioxin like compounds: in vivo verification in European starlings.	Dioxins	84-90	aryl hydrocarbon receptor	Sturnus vulgaris	27-31
25209921-1	2014	Research has demonstrated that the sensitivity of avian species to the embyrotoxic effects of dioxin-like compounds can be predicted by the amino acid identities at two key sites within the ligand-binding domain of the aryl hydrocarbon receptor 1 (AhR1).	Dioxins	94-100	aryl hydrocarbon receptor	Sturnus vulgaris	219-246
25209921-1	2014	Research has demonstrated that the sensitivity of avian species to the embyrotoxic effects of dioxin-like compounds can be predicted by the amino acid identities at two key sites within the ligand-binding domain of the aryl hydrocarbon receptor 1 (AhR1).	Dioxins	94-100	aryl hydrocarbon receptor	Sturnus vulgaris	248-252
25220434-6	2014	The disturbance in fetal growth was suggested to be due to a reduction in the level of fetal growth hormone (GH) by dioxins.	Dioxins	116-123	gonadotropin releasing hormone receptor	Rattus norvegicus	93-107
25220434-6	2014	The disturbance in fetal growth was suggested to be due to a reduction in the level of fetal growth hormone (GH) by dioxins.	Dioxins	116-123	gonadotropin releasing hormone receptor	Rattus norvegicus	109-111
25220434-9	2014	These lines of evidence suggest that: 1) PnCDF as well as TCDD imprints defects in sexual behavior by disrupting the fetal pituitary-gonad axis; 2) these dioxins hinder fetal growth by reducing the expression of fetal GH; and 3) the fetal effects of PnCDF/TCDD are more sensitive than sub-acute toxicity during puberty, and the relative effect of PnCDF varies markedly depending on the indices used.	Dioxins	154-161	gonadotropin releasing hormone receptor	Rattus norvegicus	218-220
25299844-0	2014	Endocrine disruption in human placenta: expression of the dioxin-inducible enzyme, CYP1A1, is correlated with that of thyroid hormone-regulated genes.	Dioxins	58-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
25299844-2	2014	Several chemicals including polychlorinated biphenyls are metabolized by the dioxin-inducible enzyme CYP1A1; some of their metabolites can interact with the TH receptor.	Dioxins	77-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-107
25568920-1	2014	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly referred to as "dioxin".	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	4-29
25568920-1	2014	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly referred to as "dioxin".	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	31-34
24966027-1	2014	Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites.	Dioxins	164-171	aryl hydrocarbon receptor	Homo sapiens	27-30
25084496-2	2014	Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway.	Dioxins	5-11	aryl hydrocarbon receptor	Homo sapiens	63-88
25084496-2	2014	Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway.	Dioxins	5-11	aryl hydrocarbon receptor	Homo sapiens	90-93
25178717-2	2014	Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands.	Dioxins	54-60	aryl-hydrocarbon receptor	Mus musculus	27-30
25222814-8	2014	A dioxin-responsive luciferase reporter gene assay confirmed that the CYP1A4 inductions were independent of the dissolution solvents used (tetrahydrofuran/n-hexane, n-hexane, or methanol) during photolysis.	Dioxins	2-8	cytochrome P450 1A4	Gallus gallus	70-76
28962316-1	2014	The prototype dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert anti-estrogenic effects via activation of the aryl hydrocarbon receptor (AhR) by interfering with the regulation of oestrogen homeostasis and the estrogen receptor alpha (ERalpha) signalling pathway.	Dioxins	14-20	aryl hydrocarbon receptor	Homo sapiens	137-162
28962316-1	2014	The prototype dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert anti-estrogenic effects via activation of the aryl hydrocarbon receptor (AhR) by interfering with the regulation of oestrogen homeostasis and the estrogen receptor alpha (ERalpha) signalling pathway.	Dioxins	14-20	aryl hydrocarbon receptor	Homo sapiens	164-167
25288548-3	2014	The average concentration of  PCBs (7 indicator PCB and 12 dioxin like-PCB congeners) was (16.2+-9.25) pg/g, and WHO-TEQ average concentration was 0.043+-0.049pgWHO-TEQ/g.	Dioxins	59-65	pyruvate carboxylase	Homo sapiens	30-33
28962316-1	2014	The prototype dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert anti-estrogenic effects via activation of the aryl hydrocarbon receptor (AhR) by interfering with the regulation of oestrogen homeostasis and the estrogen receptor alpha (ERalpha) signalling pathway.	Dioxins	14-20	estrogen receptor 1	Homo sapiens	237-260
28962316-1	2014	The prototype dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert anti-estrogenic effects via activation of the aryl hydrocarbon receptor (AhR) by interfering with the regulation of oestrogen homeostasis and the estrogen receptor alpha (ERalpha) signalling pathway.	Dioxins	14-20	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	262-269
25324842-2	2014	The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs).	Dioxins	139-145	aryl-hydrocarbon receptor	Mus musculus	4-29
25324842-2	2014	The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs).	Dioxins	139-145	aryl-hydrocarbon receptor	Mus musculus	31-34
24239782-5	2014	It was first believed that AhR activation accounted for most, if not all, biological properties of dioxins.	Dioxins	99-106	aryl hydrocarbon receptor	Homo sapiens	27-30
24749687-1	2014	Aryl hydrocarbon receptor (AhR) is well known for mediating the toxic effects of dioxin-containing pollutants, but has also been shown to be involved in the natural regulation of the immune response.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	0-25
25015655-1	2014	Dioxin is a ubiquitous environmental pollutant that induces toxicity when bound to the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	87-112
25015655-1	2014	Dioxin is a ubiquitous environmental pollutant that induces toxicity when bound to the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	114-117
25015655-2	2014	Significant differences in susceptibility of mouse strains to dioxin toxicity are largely accounted for by the dissociation constant of binding to dioxins of AhR subtypes encoded by different alleles.	Dioxins	62-68	aryl-hydrocarbon receptor	Mus musculus	158-161
25015655-2	2014	Significant differences in susceptibility of mouse strains to dioxin toxicity are largely accounted for by the dissociation constant of binding to dioxins of AhR subtypes encoded by different alleles.	Dioxins	147-154	aryl-hydrocarbon receptor	Mus musculus	158-161
25257533-3	2014	Most dioxin-like pollutants activate the aryl hydrocarbon receptor (AhR) transcription factor, which regulates xenobiotic metabolism enzymes that belong to the cytochrome P450 1A family (that includes CYP1A1 and CYP1B1).	Dioxins	5-11	aryl hydrocarbon receptor	Homo sapiens	41-66
25257533-3	2014	Most dioxin-like pollutants activate the aryl hydrocarbon receptor (AhR) transcription factor, which regulates xenobiotic metabolism enzymes that belong to the cytochrome P450 1A family (that includes CYP1A1 and CYP1B1).	Dioxins	5-11	aryl hydrocarbon receptor	Homo sapiens	68-71
25257533-3	2014	Most dioxin-like pollutants activate the aryl hydrocarbon receptor (AhR) transcription factor, which regulates xenobiotic metabolism enzymes that belong to the cytochrome P450 1A family (that includes CYP1A1 and CYP1B1).	Dioxins	5-11	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	201-207
25257533-3	2014	Most dioxin-like pollutants activate the aryl hydrocarbon receptor (AhR) transcription factor, which regulates xenobiotic metabolism enzymes that belong to the cytochrome P450 1A family (that includes CYP1A1 and CYP1B1).	Dioxins	5-11	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	212-218
24967557-7	2014	Moreover, when we analyzed the results of the congeners (non-dioxin-like PCBs and dioxin-like PCBs), the levels of non-dioxin-like PCB congeners ranged from 5.7 to 103469 mug kg(-1) and the levels of dioxin-like PCB congeners ranged from 0.5 to 4992 mug kg(-1).	Dioxins	61-67	pyruvate carboxylase	Homo sapiens	73-76
24967557-7	2014	Moreover, when we analyzed the results of the congeners (non-dioxin-like PCBs and dioxin-like PCBs), the levels of non-dioxin-like PCB congeners ranged from 5.7 to 103469 mug kg(-1) and the levels of dioxin-like PCB congeners ranged from 0.5 to 4992 mug kg(-1).	Dioxins	82-88	pyruvate carboxylase	Homo sapiens	94-97
24967557-7	2014	Moreover, when we analyzed the results of the congeners (non-dioxin-like PCBs and dioxin-like PCBs), the levels of non-dioxin-like PCB congeners ranged from 5.7 to 103469 mug kg(-1) and the levels of dioxin-like PCB congeners ranged from 0.5 to 4992 mug kg(-1).	Dioxins	82-88	pyruvate carboxylase	Homo sapiens	94-97
24967557-7	2014	Moreover, when we analyzed the results of the congeners (non-dioxin-like PCBs and dioxin-like PCBs), the levels of non-dioxin-like PCB congeners ranged from 5.7 to 103469 mug kg(-1) and the levels of dioxin-like PCB congeners ranged from 0.5 to 4992 mug kg(-1).	Dioxins	82-88	pyruvate carboxylase	Homo sapiens	94-97
25137063-1	2014	PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment.	Dioxins	28-34	pyruvate carboxylase	Rattus norvegicus	0-3
25137063-1	2014	PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment.	Dioxins	28-34	pyruvate carboxylase	Rattus norvegicus	70-73
24749687-1	2014	Aryl hydrocarbon receptor (AhR) is well known for mediating the toxic effects of dioxin-containing pollutants, but has also been shown to be involved in the natural regulation of the immune response.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	27-30
22987612-4	2014	Dioxin-like congener PCB126 binding aryl hydrocarbon receptor (AHR) is responsible of many toxic effects.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	36-61
22987612-4	2014	Dioxin-like congener PCB126 binding aryl hydrocarbon receptor (AHR) is responsible of many toxic effects.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	63-66
24793433-0	2014	Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: a comparative study using two strains of mice with different sensitivities to dioxin.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	133-158
24926919-1	2014	Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor.	Dioxins	58-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
24926919-1	2014	Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor.	Dioxins	58-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	121-127
24926919-1	2014	Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor.	Dioxins	58-64	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	132-138
24926919-1	2014	Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	157-196
24824450-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs.	Dioxins	164-170	aryl hydrocarbon receptor	Homo sapiens	4-29
24824450-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs.	Dioxins	164-170	aryl hydrocarbon receptor	Homo sapiens	31-34
25137063-13	2014	However, PCB 180 shares several toxicological targets with dioxin-like compounds emphasizing the potential for interactions.	Dioxins	59-65	pyruvate carboxylase	Rattus norvegicus	9-12
25007155-1	2014	BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	104-111	aryl hydrocarbon receptor	Homo sapiens	12-37
25007155-1	2014	BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	104-111	aryl hydrocarbon receptor	Homo sapiens	39-42
25011475-9	2014	Chromatin immunoprecipitation assays demonstrated that omeprazole recruited the AHR to regions in the CXCR4 promoter that contain dioxin response elements (DREs) and this was accompanied by the loss of pol II on the promoter and decreased expression of CXCR4.	Dioxins	130-136	aryl hydrocarbon receptor	Homo sapiens	80-83
24718703-4	2014	The importance of this question arose from our earlier observation that aspects of the acute hepatocellular toxicity of dioxin are dependent upon IL1-like cytokine signaling.	Dioxins	120-126	interleukin 1 complex	Mus musculus	146-149
25011475-9	2014	Chromatin immunoprecipitation assays demonstrated that omeprazole recruited the AHR to regions in the CXCR4 promoter that contain dioxin response elements (DREs) and this was accompanied by the loss of pol II on the promoter and decreased expression of CXCR4.	Dioxins	130-136	C-X-C motif chemokine receptor 4	Homo sapiens	102-107
24680724-4	2014	Bioinformatic analysis of gene expression data highlighted the importance of the aryl hydrocarbon receptor (AHR) in dioxin toxicity and revealed that zinc regulation in the brain is targeted by TCDD through the AHR.	Dioxins	116-122	aryl-hydrocarbon receptor	Mus musculus	81-106
24680724-4	2014	Bioinformatic analysis of gene expression data highlighted the importance of the aryl hydrocarbon receptor (AHR) in dioxin toxicity and revealed that zinc regulation in the brain is targeted by TCDD through the AHR.	Dioxins	116-122	aryl-hydrocarbon receptor	Mus musculus	108-111
24987953-3	2014	Aryl hydrocarbon receptor (AhR) is a master regulator of dioxin-mediated toxic effects, and is, therefore, critical in maintaining adaptive responses through regulating the expression of phase I/II drug metabolism enzymes.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	0-25
24987953-3	2014	Aryl hydrocarbon receptor (AhR) is a master regulator of dioxin-mediated toxic effects, and is, therefore, critical in maintaining adaptive responses through regulating the expression of phase I/II drug metabolism enzymes.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	27-30
24987953-8	2014	This review highlights recent advances in the understanding of the reciprocal interactions between dioxin-mediated AhR signaling and the circadian clock including how these pathways relate to health and disease, with emphasis on the control of metabolic function.	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	115-118
24718703-2	2014	To this end, we first employed congenic mice homozygous for either the Ahr(b1) or Ahr(d) alleles (encoding an aryl hydrocarbon receptor (AHR) with high or low binding affinity for dioxin, respectively) and demonstrated that hepatocellular tumor promotion in response to dioxin segregated with the Ahr locus.	Dioxins	180-186	aryl-hydrocarbon receptor	Mus musculus	137-140
24083809-3	2014	The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	4-29
24083809-3	2014	The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	31-34
24083809-4	2014	Recent studies show that dioxin mediates its immune toxic effects via AhR and that AhR activation induces dysregulation of interleukin (IL)-17- producing T (TH17) cells.	Dioxins	25-31	aryl hydrocarbon receptor	Homo sapiens	70-73
24243026-0	2014	Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro.	Dioxins	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
24243026-0	2014	Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro.	Dioxins	11-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
24243026-4	2014	In the present study, the effects of several other dioxin-like compounds (DLCs) on neuronal AChE activity were determined, including 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrabromodibenzo-p-dioxin.	Dioxins	51-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96
24243026-7	2014	These findings on DLCs are similar with those on 2,3,7,8-TCDD, pointing to the possibility that exposure to dioxin and DLCs, which frequently coexist in the contaminated environments, may concurrently interfere with the cholinergic functions via AChE.	Dioxins	108-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	246-250
24769090-1	2014	The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented.	Dioxins	21-28	aryl-hydrocarbon receptor	Mus musculus	115-140
24769090-1	2014	The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented.	Dioxins	21-28	aryl-hydrocarbon receptor	Mus musculus	142-145
24718703-7	2014	Collectively, these data support the idea that the mechanism of dioxin acute hepatotoxicity and its activity as a promoter in a mouse two stage liver cancer model may be similar, i.e., tumor promotion by dioxin, like acute hepatotoxicity, are mediated by the linked action of two receptor systems, the AHR and the receptors for the "IL-1-like" cytokines.	Dioxins	64-70	aryl-hydrocarbon receptor	Mus musculus	302-305
24718703-7	2014	Collectively, these data support the idea that the mechanism of dioxin acute hepatotoxicity and its activity as a promoter in a mouse two stage liver cancer model may be similar, i.e., tumor promotion by dioxin, like acute hepatotoxicity, are mediated by the linked action of two receptor systems, the AHR and the receptors for the "IL-1-like" cytokines.	Dioxins	64-70	interleukin 1 complex	Mus musculus	333-337
23644946-2	2014	We previously reported that PCB 126, the most potent dioxin-like PCB congener, not only decreases antioxidants such as hepatic selenium (Se), Se-dependent glutathione peroxidase, and glutathione (GSH) but also increases levels of the antiatherosclerosis enzyme paraoxonase 1 (PON1) in liver and serum.	Dioxins	53-59	pyruvate carboxylase	Rattus norvegicus	28-31
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Dioxins	205-211	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	4-50
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Dioxins	205-211	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	52-56
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Dioxins	205-211	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	78-114
24549985-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates immunosuppression caused by a variety of environmental contaminants, such as polycyclic aromatic hydrocarbons or dioxins.	Dioxins	206-213	aryl hydrocarbon receptor	Homo sapiens	4-29
24549985-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates immunosuppression caused by a variety of environmental contaminants, such as polycyclic aromatic hydrocarbons or dioxins.	Dioxins	206-213	aryl hydrocarbon receptor	Homo sapiens	31-34
24743890-13	2014	The effects of DRE orientation, DRE adjacent sequences and the nucleotide "N" in the core DRE (5"-TNGCGTG-3") sequence on the AhR-regulated CYP1A1 transcription in response to TCDD were studied systematically, and our study laid a good foundation for further investigation into the AhR-dependent transcriptional regulation triggered by dioxin and dioxin-like compounds.	Dioxins	336-342	aryl-hydrocarbon receptor	Mus musculus	126-129
24743890-13	2014	The effects of DRE orientation, DRE adjacent sequences and the nucleotide "N" in the core DRE (5"-TNGCGTG-3") sequence on the AhR-regulated CYP1A1 transcription in response to TCDD were studied systematically, and our study laid a good foundation for further investigation into the AhR-dependent transcriptional regulation triggered by dioxin and dioxin-like compounds.	Dioxins	347-353	aryl-hydrocarbon receptor	Mus musculus	126-129
24472611-1	2014	Human risk assessment for dioxin-like compounds is typically based on the concentration measured in blood serum multiplied by their assigned toxic equivalency factor (TEF).	Dioxins	26-32	TEF transcription factor, PAR bZIP family member	Homo sapiens	141-165
24472611-1	2014	Human risk assessment for dioxin-like compounds is typically based on the concentration measured in blood serum multiplied by their assigned toxic equivalency factor (TEF).	Dioxins	26-32	TEF transcription factor, PAR bZIP family member	Homo sapiens	167-170
24417285-1	2014	BACKGROUND AND PURPOSE: GNF-351 is a potent aryl hydrocarbon receptor (AHR) antagonist that inhibits dioxin response element-dependent and independent activities.	Dioxins	101-107	aryl-hydrocarbon receptor	Mus musculus	44-69
24417285-1	2014	BACKGROUND AND PURPOSE: GNF-351 is a potent aryl hydrocarbon receptor (AHR) antagonist that inhibits dioxin response element-dependent and independent activities.	Dioxins	101-107	aryl-hydrocarbon receptor	Mus musculus	71-74
24434118-3	2014	Here, we modified a cell-based binding assay that allowed us to measure the binding affinity of dioxin-like compounds (DLCs) to avian AHR1 expressed in COS-7 (fibroblast-like cells).	Dioxins	96-102	aryl hydrocarbon receptor	Coturnix japonica	134-138
24503019-7	2014	Indeed, SLPI, SPRR2, and epigen were strongly expressed in cysts of MADISH patients and upregulated by dioxin in human keratinocytes in an NRF2-dependent manner.	Dioxins	103-109	secretory leukocyte peptidase inhibitor	Homo sapiens	8-12
24503019-7	2014	Indeed, SLPI, SPRR2, and epigen were strongly expressed in cysts of MADISH patients and upregulated by dioxin in human keratinocytes in an NRF2-dependent manner.	Dioxins	103-109	epithelial mitogen	Homo sapiens	25-31
24503019-7	2014	Indeed, SLPI, SPRR2, and epigen were strongly expressed in cysts of MADISH patients and upregulated by dioxin in human keratinocytes in an NRF2-dependent manner.	Dioxins	103-109	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
24211603-4	2014	Utilizing in vitro approaches, we observed that Genistein and BPA suppress inhibitory and activate stimulatory components of the GnRH network, while Dioxin exhibit an inhibitory effect at all regulatory hierarchical levels of the GnRH network.	Dioxins	149-155	gonadotropin releasing hormone 1	Homo sapiens	230-234
24486495-4	2014	Toxicological evaluation by TCA and TEQ methods, conducted for the first time in Venice air samples, identified BaP, PCB-126 and PCB-169 as the most important contributors to the total carcinogenic activity of PAHs and the total dioxin-like activity of PCBs and PCNs.	Dioxins	229-235	pyruvate carboxylase	Homo sapiens	129-132
24599232-9	2014	We discuss here how the cardiovascular effects of these uremic toxins could be mediated by AhR activation, in a "dioxin-like" effect.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	91-94
24586095-3	2014	We aimed to investigate whether early exposure of healthy infants to dioxin-like chemicals was associated with changes in early childhood growth and serum IGF1.	Dioxins	69-75	insulin like growth factor 1	Homo sapiens	155-159
24586095-11	2014	Environmental exposure to dioxin-like chemicals was associated with being skinny at birth and with higher infant levels of circulating IGF1 as well as accelerated early childhood growth (rapid catch-up growth).	Dioxins	26-32	insulin like growth factor 1	Homo sapiens	135-139
24311719-1	2014	The environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) binds and activates the transcription factor aryl hydrocarbon receptor (AHR), inducing CYP1 family cytochrome P450 enzymes.	Dioxins	68-74	aryl hydrocarbon receptor 1 alpha	Gallus gallus	162-165
24794981-2	2014	Recently it has been demonstrated the potentiality of detecting dioxins in carbon tetrachloride via MIR Quantum Cascade Lasers.	Dioxins	64-71	MLX interacting protein	Homo sapiens	100-103
24743890-0	2014	Functional analysis of the dioxin response elements (DREs) of the murine CYP1A1 gene promoter: beyond the core DRE sequence.	Dioxins	27-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	73-79
24743890-2	2014	When activated by dioxin, the cytosolic AhR protein complex translocates into the nucleus and dimerizes with the ARNT (Ah receptor nuclear translocator) protein.	Dioxins	18-24	aryl-hydrocarbon receptor	Mus musculus	40-43
24743890-2	2014	When activated by dioxin, the cytosolic AhR protein complex translocates into the nucleus and dimerizes with the ARNT (Ah receptor nuclear translocator) protein.	Dioxins	18-24	aryl hydrocarbon receptor nuclear translocator	Mus musculus	113-117
24743890-2	2014	When activated by dioxin, the cytosolic AhR protein complex translocates into the nucleus and dimerizes with the ARNT (Ah receptor nuclear translocator) protein.	Dioxins	18-24	aryl hydrocarbon receptor nuclear translocator	Mus musculus	119-151
24743890-3	2014	The heteromeric ligand:AhR/Arnt complex then recognizes and binds to its specific DNA recognition site, the dioxin response element (DRE).	Dioxins	108-114	aryl-hydrocarbon receptor	Mus musculus	23-26
24743890-3	2014	The heteromeric ligand:AhR/Arnt complex then recognizes and binds to its specific DNA recognition site, the dioxin response element (DRE).	Dioxins	108-114	aryl hydrocarbon receptor nuclear translocator	Mus musculus	27-31
24565903-5	2014	The cells were incubated with dioxin (TCDD) - AhR model inducer, IL-1 and TNF-alpha.	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	46-49
24565903-5	2014	The cells were incubated with dioxin (TCDD) - AhR model inducer, IL-1 and TNF-alpha.	Dioxins	30-36	tumor necrosis factor	Homo sapiens	74-83
24565903-8	2014	RESULTS: In general, dioxin did not significantly influence the expression of AHR and ARNT, but reduced AHRR level.	Dioxins	21-27	aryl hydrocarbon receptor repressor	Homo sapiens	104-108
24363052-6	2014	Aryl hydrocarbon receptor-dependent potency (dioxin-like potency) expressed as biological TCDD-equivalents (BIOTEQ) was in the range of 0.5-17.7 ng/g, dry mass (dm).	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	0-25
24431146-1	2014	Previous studies in hepatocyte-derived cell lines and the whole liver established that the aryl hydrocarbon receptor (AhR) can disrupt G1-phase cell cycle progression following exposure to persistent AhR agonists, such as TCDD (dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin).	Dioxins	228-234	aryl-hydrocarbon receptor	Mus musculus	91-116
24431146-1	2014	Previous studies in hepatocyte-derived cell lines and the whole liver established that the aryl hydrocarbon receptor (AhR) can disrupt G1-phase cell cycle progression following exposure to persistent AhR agonists, such as TCDD (dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin).	Dioxins	228-234	aryl-hydrocarbon receptor	Mus musculus	118-121
24431146-1	2014	Previous studies in hepatocyte-derived cell lines and the whole liver established that the aryl hydrocarbon receptor (AhR) can disrupt G1-phase cell cycle progression following exposure to persistent AhR agonists, such as TCDD (dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin).	Dioxins	228-234	aryl-hydrocarbon receptor	Mus musculus	200-203
24774064-9	2014	Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.	Dioxins	118-124	pyruvate carboxylase	Homo sapiens	130-133
24495120-3	2014	Persistent AhR activation by dioxin, a potent agonist, results in altered numbers and function of HSCs in mice.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	11-14
24363026-1	2014	Risk assessment for mixtures of dioxin-like compounds uses the toxic equivalency factor (TEF) approach.	Dioxins	32-38	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	63-87
24363026-1	2014	Risk assessment for mixtures of dioxin-like compounds uses the toxic equivalency factor (TEF) approach.	Dioxins	32-38	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	89-92
24220260-0	2014	PCDD/F and dioxin-like PCB concentrations during municipal solid waste biomethanation and subsequent composting.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
24220260-1	2014	PCDD/F and dioxin-like PCB concentrations were compared in different samples of a municipal solid waste (MSW) treatment plant: the initial MSW fraction that enters the biomethanation from the digester, the semi-solid digestate obtained after biomethanation of MSW, and the solids after composting the digestate since the final product is destined for land application and special attention must be paid to these compounds for environmental considerations.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
24252472-9	2014	Gene expression levels were significantly lower for 11 genes in association with the highest versus lowest category of plasma AR CALUX  (chemically activated luciferase expression for androgens) (8 genes), ERalpha CALUX  (for estrogens) (2 genes), and DR CALUX  (for dioxins).	Dioxins	267-274	estrogen receptor 1	Homo sapiens	206-213
23644946-2	2014	We previously reported that PCB 126, the most potent dioxin-like PCB congener, not only decreases antioxidants such as hepatic selenium (Se), Se-dependent glutathione peroxidase, and glutathione (GSH) but also increases levels of the antiatherosclerosis enzyme paraoxonase 1 (PON1) in liver and serum.	Dioxins	53-59	pyruvate carboxylase	Rattus norvegicus	65-68
24355420-1	2014	The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs).	Dioxins	149-155	aryl hydrocarbon receptor	Homo sapiens	4-29
24355420-1	2014	The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs).	Dioxins	149-155	aryl hydrocarbon receptor	Homo sapiens	31-34
24481452-2	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity.	Dioxins	114-120	aryl hydrocarbon receptor	Homo sapiens	4-29
23928371-6	2014	Changes in the toxic equivalent (TEQ) values during deca-BDE debromination parallel the occurrence and transformation of specific low brominated congeners with dioxin-like potency.	Dioxins	160-166	homeobox D13	Homo sapiens	57-60
24481452-2	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity.	Dioxins	114-120	aryl hydrocarbon receptor	Homo sapiens	31-34
24422594-14	2014	The results suggest that AHRs, and especially AHR2, may be important, recurring targets for selection in local adaptation to dioxin-like aromatic hydrocarbon contaminants.	Dioxins	125-131	aryl hydrocarbon receptor-like	Fundulus heteroclitus	46-50
25292121-6	2014	BRIEF DESCRIPTION OF THE STATE OF KNOWLEDGE: Apart from the knowledge of dioxins affinity to the aryl hydrocarbon receptor (AhR), the multi-stage radical-form actions and the pro-inflammatory mechanism associated with cyclooxygenase-II enzyme (COX-2) are under intense investigation at the moment.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	97-122
25292121-6	2014	BRIEF DESCRIPTION OF THE STATE OF KNOWLEDGE: Apart from the knowledge of dioxins affinity to the aryl hydrocarbon receptor (AhR), the multi-stage radical-form actions and the pro-inflammatory mechanism associated with cyclooxygenase-II enzyme (COX-2) are under intense investigation at the moment.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	124-127
24245878-5	2014	Liver tumors induced by ligands of the AHR were assessed using data for dioxins and related chemicals as a case study.	Dioxins	72-79	aryl hydrocarbon receptor	Homo sapiens	39-42
24200861-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates the biological and toxicological effects of structurally diverse chemicals through its ability to bind specific DNA recognition sites (dioxin responsive elements (DREs)), and activate transcription of adjacent genes.	Dioxins	228-234	aryl hydrocarbon receptor	Homo sapiens	4-29
24200861-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates the biological and toxicological effects of structurally diverse chemicals through its ability to bind specific DNA recognition sites (dioxin responsive elements (DREs)), and activate transcription of adjacent genes.	Dioxins	228-234	aryl hydrocarbon receptor	Homo sapiens	31-34
24369137-5	2014	Dioxins and dioxin-like EDCs exert their biological and toxicological actions through activation of the aryl hydrocarbon-receptor, which besides inducing transcription of detoxifying enzymes also regulates transcriptional activity of other nuclear receptors.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	104-129
24369137-5	2014	Dioxins and dioxin-like EDCs exert their biological and toxicological actions through activation of the aryl hydrocarbon-receptor, which besides inducing transcription of detoxifying enzymes also regulates transcriptional activity of other nuclear receptors.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	104-129
24120012-6	2014	As a measure of environmental risk of dioxins (EDR) we used the interpolated values of dioxins concentration in buffalo milk samples collected in the study area.	Dioxins	38-45	paternally expressed 10	Homo sapiens	47-50
24120012-6	2014	As a measure of environmental risk of dioxins (EDR) we used the interpolated values of dioxins concentration in buffalo milk samples collected in the study area.	Dioxins	87-94	paternally expressed 10	Homo sapiens	47-50
24120012-8	2014	The dioxin level in breast milk is significantly correlated to the EDR, the age of the sampled women and the presence of illegal burning of solid waste.	Dioxins	4-10	paternally expressed 10	Homo sapiens	67-70
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	4-10	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	4-10	Pyruvate carboxylase	Drosophila melanogaster	63-66
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	4-10	Pyruvate carboxylase	Drosophila melanogaster	63-66
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	121-127	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	121-127	Pyruvate carboxylase	Drosophila melanogaster	63-66
24120013-2	2014	The dioxin-like PCB fingerprints of the waste inputs show that PCB oils Aroclor 1242 and Aroclor 1254 late are the major dioxin-like PCB contamination source of sludge, RDF and ASR.	Dioxins	121-127	Pyruvate carboxylase	Drosophila melanogaster	63-66
24120013-3	2014	The dioxin-like PCB fingerprints of the waste inputs are clearly different from the fingerprints of the outputs, i.e. boiler and fly ash, indicating that in full scale waste incinerators dioxin-like PCBs in the input waste are destroyed and other dioxin-like PCBs are newly formed in the post combustion zone.	Dioxins	4-10	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-3	2014	The dioxin-like PCB fingerprints of the waste inputs are clearly different from the fingerprints of the outputs, i.e. boiler and fly ash, indicating that in full scale waste incinerators dioxin-like PCBs in the input waste are destroyed and other dioxin-like PCBs are newly formed in the post combustion zone.	Dioxins	187-193	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-3	2014	The dioxin-like PCB fingerprints of the waste inputs are clearly different from the fingerprints of the outputs, i.e. boiler and fly ash, indicating that in full scale waste incinerators dioxin-like PCBs in the input waste are destroyed and other dioxin-like PCBs are newly formed in the post combustion zone.	Dioxins	187-193	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-4	2014	The dioxin-like PCB fingerprint of boiler and fly ash of all three incinerators corresponds well to the fly ash fingerprint obtained in lab scale de novo synthesis experiments, indicating that dioxin-like PCBs are mainly formed through this mechanism.	Dioxins	4-10	Pyruvate carboxylase	Drosophila melanogaster	16-19
24120013-4	2014	The dioxin-like PCB fingerprint of boiler and fly ash of all three incinerators corresponds well to the fly ash fingerprint obtained in lab scale de novo synthesis experiments, indicating that dioxin-like PCBs are mainly formed through this mechanism.	Dioxins	193-199	Pyruvate carboxylase	Drosophila melanogaster	16-19
24245878-10	2014	The current effort of applying the systematic frameworks for identifying key events and assessing human relevance to the AHR activation in the tumorigenicity of dioxins and related chemicals is novel at this time.	Dioxins	161-168	aryl hydrocarbon receptor	Homo sapiens	121-124
24162035-7	2014	RESULTS: Maternal serum concentrations of HCB and dioxin-like PCB-118 were positively associated with offspring asthma medication use after 20 years of follow-up (p for trend<0.05).	Dioxins	50-56	pyruvate carboxylase	Homo sapiens	62-65
25798032-4	2014	We herein devote space to several classes of endocrine-disrupting compounds (EDCs), including estrogenic substances such as bisphenol A (BPA), molecules that can behave at times anti-estrogenically while activating the aromatic hydrocarbon receptor (AHR), such as dioxins (a known human carcinogen), and novel, ubiquitous molecules such as nanoparticles, particularly gold nanoparticles (GNPs), that appear to alter the sexsteroid biosynthetic pathway.	Dioxins	264-271	aryl hydrocarbon receptor	Homo sapiens	219-248
24162035-10	2014	Weak positive associations were also estimated for PCB-156 and the non-dioxin-like PCBs (PCBs 138, 153, 170, 180).	Dioxins	71-77	pyruvate carboxylase	Homo sapiens	51-54
24275543-8	2014	We found a significant interaction between dioxin-like PCB concentration and age in association with cognitive score (p=0.04).	Dioxins	43-49	pyruvate carboxylase	Homo sapiens	55-58
24588224-8	2014	The effects on tissue retinoid levels and changes in CYP enzyme activities, body and liver weights, and thyroid hormone levels were associated and likely driven by dioxin-like compounds in the mixture.	Dioxins	164-170	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-56
23925657-0	2014	Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	132-135
24754391-2	2014	AhR agonist activity was determined using the dioxin-responsive chemically activated luciferase expression (DR-CALUX) assay to calculate the toxic equivalent quotient (TEQ)CALUX.	Dioxins	46-52	aryl hydrocarbon receptor	Homo sapiens	0-3
24132183-0	2014	Maternal exposure to dioxin imprints sexual immaturity of the pups through fixing the status of the reduced expression of hypothalamic gonadotropin-releasing hormone.	Dioxins	21-27	gonadotropin releasing hormone 1	Rattus norvegicus	135-165
24476589-3	2014	Dioxin toxicity, which has raised a significant concern in society, was discovered to be mediated by a high-affinity receptor, aryl hydrocarbon receptor (AhR), more than three decades ago.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	127-152
24476589-3	2014	Dioxin toxicity, which has raised a significant concern in society, was discovered to be mediated by a high-affinity receptor, aryl hydrocarbon receptor (AhR), more than three decades ago.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	154-157
24476589-5	2014	However, it has not been clarified how AhR mediates such a wide variety of dioxin toxicities through AhR-dependent mechanisms.	Dioxins	75-81	aryl-hydrocarbon receptor	Mus musculus	39-42
24476589-5	2014	However, it has not been clarified how AhR mediates such a wide variety of dioxin toxicities through AhR-dependent mechanisms.	Dioxins	75-81	aryl-hydrocarbon receptor	Mus musculus	101-104
24476589-9	2014	As the molecular basis of the tissue-specific endpoints of dioxin toxicity, dysregulation of AhR downstream pathways, such as signaling of prostanoid synthesis, Wnt/beta-catenin signaling, and signaling by receptors for inflammatory cytokines, are discussed.	Dioxins	59-65	aryl-hydrocarbon receptor	Mus musculus	93-96
24154488-0	2014	Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.	Dioxins	67-73	aryl-hydrocarbon receptor	Mus musculus	0-25
24136190-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and a wide variety of structurally diverse ligands through its ability to translocate into the nucleus and bind to a specific DNA recognition site (the dioxin-responsive element [DRE]) adjacent to responsive genes.	Dioxins	158-164	aryl hydrocarbon receptor	Cavia porcellus	4-29
24136190-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and a wide variety of structurally diverse ligands through its ability to translocate into the nucleus and bind to a specific DNA recognition site (the dioxin-responsive element [DRE]) adjacent to responsive genes.	Dioxins	158-164	aryl hydrocarbon receptor	Cavia porcellus	31-34
24136190-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and a wide variety of structurally diverse ligands through its ability to translocate into the nucleus and bind to a specific DNA recognition site (the dioxin-responsive element [DRE]) adjacent to responsive genes.	Dioxins	172-178	aryl hydrocarbon receptor	Cavia porcellus	4-29
24136190-1	2014	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and a wide variety of structurally diverse ligands through its ability to translocate into the nucleus and bind to a specific DNA recognition site (the dioxin-responsive element [DRE]) adjacent to responsive genes.	Dioxins	172-178	aryl hydrocarbon receptor	Cavia porcellus	31-34
23855798-5	2013	AhR was bound to dioxin-responsive element and transcriptionally active in both TCDD-untreated and -treated lung adenocarcinoma cells.	Dioxins	17-23	aryl hydrocarbon receptor	Homo sapiens	0-3
23855798-9	2013	Colocalization of ERalpha and AhR at the estrogen-responsive site under E2 and TCDD/E2 treatments implied that E2   ERalpha might hijack AhR away from the dioxin-responsive site.	Dioxins	155-161	estrogen receptor 1	Homo sapiens	18-25
23855798-9	2013	Colocalization of ERalpha and AhR at the estrogen-responsive site under E2 and TCDD/E2 treatments implied that E2   ERalpha might hijack AhR away from the dioxin-responsive site.	Dioxins	155-161	aryl hydrocarbon receptor	Homo sapiens	30-33
23855798-9	2013	Colocalization of ERalpha and AhR at the estrogen-responsive site under E2 and TCDD/E2 treatments implied that E2   ERalpha might hijack AhR away from the dioxin-responsive site.	Dioxins	155-161	estrogen receptor 1	Homo sapiens	116-123
23855798-9	2013	Colocalization of ERalpha and AhR at the estrogen-responsive site under E2 and TCDD/E2 treatments implied that E2   ERalpha might hijack AhR away from the dioxin-responsive site.	Dioxins	155-161	aryl hydrocarbon receptor	Homo sapiens	137-140
23855798-13	2013	In conclusion, AhR/ERalpha expression pattern, estrogen level, and promoter context determine the genomic action of dioxin in lung adenocarcinoma cells.	Dioxins	116-122	aryl hydrocarbon receptor	Homo sapiens	15-18
23855798-13	2013	In conclusion, AhR/ERalpha expression pattern, estrogen level, and promoter context determine the genomic action of dioxin in lung adenocarcinoma cells.	Dioxins	116-122	estrogen receptor 1	Homo sapiens	19-26
23690076-4	2013	RePs of 21 polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls that exhibit effects mediated through the AhR were determined by use of the H4IIE-luc assay.	Dioxins	37-43	aryl hydrocarbon receptor	Homo sapiens	161-164
23933243-0	2013	Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study.	Dioxins	4-10	solute carrier family 6 member 3	Rattus norvegicus	61-81
24014653-0	2013	Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction.	Dioxins	76-82	ryanodine receptor 1, skeletal muscle	Mus musculus	127-131
24035824-1	2013	Bone is a target for high affinity aryl hydrocarbon receptor (AHR) ligands, such as dioxins.	Dioxins	84-91	aryl-hydrocarbon receptor	Mus musculus	35-60
24035824-1	2013	Bone is a target for high affinity aryl hydrocarbon receptor (AHR) ligands, such as dioxins.	Dioxins	84-91	aryl-hydrocarbon receptor	Mus musculus	62-65
24311719-1	2014	The environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) binds and activates the transcription factor aryl hydrocarbon receptor (AHR), inducing CYP1 family cytochrome P450 enzymes.	Dioxins	68-74	aryl hydrocarbon receptor 1 alpha	Gallus gallus	135-160
25306601-6	2014	Variable sensitivity to dioxins was demonstrated by associations of genetic polymorphism (CYP1A1, GSTM1, GSTT1, n = 195) and congenital morphogenetic variants among children (n = 1734).	Dioxins	24-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
25306601-6	2014	Variable sensitivity to dioxins was demonstrated by associations of genetic polymorphism (CYP1A1, GSTM1, GSTT1, n = 195) and congenital morphogenetic variants among children (n = 1734).	Dioxins	24-31	glutathione S-transferase mu 1	Homo sapiens	98-103
25306601-6	2014	Variable sensitivity to dioxins was demonstrated by associations of genetic polymorphism (CYP1A1, GSTM1, GSTT1, n = 195) and congenital morphogenetic variants among children (n = 1734).	Dioxins	24-31	glutathione S-transferase theta 1	Homo sapiens	105-110
23912877-0	2013	Dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	55-79
23855798-0	2013	Dioxin and estrogen signaling in lung adenocarcinoma cells with different aryl hydrocarbon receptor/estrogen receptor alpha phenotypes.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	74-99
24127753-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the toxicity of dioxins, polycyclic aromatic hydrocarbons and related environmental pollutants.	Dioxins	109-116	aryl hydrocarbon receptor	Homo sapiens	4-29
24127753-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the toxicity of dioxins, polycyclic aromatic hydrocarbons and related environmental pollutants.	Dioxins	109-116	aryl hydrocarbon receptor	Homo sapiens	31-34
23997109-1	2013	Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause toxic effects through activation of the aryl hydrocarbon receptor (AHR)-mediated signaling pathway.	Dioxins	0-7	aryl hydrocarbon receptor 1 alpha	Gallus gallus	107-132
23997109-1	2013	Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause toxic effects through activation of the aryl hydrocarbon receptor (AHR)-mediated signaling pathway.	Dioxins	0-7	aryl hydrocarbon receptor 1 alpha	Gallus gallus	134-137
23997109-11	2013	Collectively, our findings discover the role of ckAHR1beta in dioxin toxicity and give an insight into the evolutionary history of the AHR signaling pathway.	Dioxins	62-68	aryl hydrocarbon receptor 1 alpha	Gallus gallus	50-53
24150760-1	2013	PURPOSE: Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic.	Dioxins	62-69	aryl hydrocarbon receptor	Homo sapiens	21-46
24026525-7	2013	As for physiological effects on the Japanese field mouse, high levels of cytochrome P450 1A1 (CYP1A1) mRNA, a drug metabolizing enzyme induced by dioxins, were found in the livers of mice captured at polluted sites.	Dioxins	146-153	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	73-92
24150760-1	2013	PURPOSE: Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic.	Dioxins	62-69	aryl hydrocarbon receptor	Homo sapiens	48-51
24236133-3	2013	Monitoring of dioxin-like PCBs in transgenic plants carrying the mammalian aryl hydrocarbon receptor (AHR) has been reported previously.	Dioxins	14-20	aryl hydrocarbon receptor	Homo sapiens	75-100
24236133-3	2013	Monitoring of dioxin-like PCBs in transgenic plants carrying the mammalian aryl hydrocarbon receptor (AHR) has been reported previously.	Dioxins	14-20	aryl hydrocarbon receptor	Homo sapiens	102-105
24236133-4	2013	Herein, we report the biomonitoring of non-dioxin-like PCBs (NDL-PCBs) using the mammalian pregnane X receptor (PXR).	Dioxins	43-49	nuclear receptor subfamily 1 group I member 2	Homo sapiens	91-110
24236133-4	2013	Herein, we report the biomonitoring of non-dioxin-like PCBs (NDL-PCBs) using the mammalian pregnane X receptor (PXR).	Dioxins	43-49	nuclear receptor subfamily 1 group I member 2	Homo sapiens	112-115
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	110-116	aryl hydrocarbon receptor	Homo sapiens	58-61
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-69
24026525-7	2013	As for physiological effects on the Japanese field mouse, high levels of cytochrome P450 1A1 (CYP1A1) mRNA, a drug metabolizing enzyme induced by dioxins, were found in the livers of mice captured at polluted sites.	Dioxins	146-153	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	94-100
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	110-116	hematopoietic prostaglandin D synthase	Homo sapiens	73-77
24026525-8	2013	Furthermore, at such sites polluted with dioxins, increased CYP1A1 expression coincided with reduced numbers of active spermatozoa in mice.	Dioxins	41-48	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	60-66
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	172-178	aryl hydrocarbon receptor	Homo sapiens	58-61
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	172-178	hematopoietic prostaglandin D synthase	Homo sapiens	73-77
24084256-3	2013	The zebrafish (Danio rerio) has three identified AHRs: AHR1A and AHR1B, the roles of which are not yet well elucidated, and AHR2, which has been shown to mediate the toxicity of various anthropogenic compounds including dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	220-227	aryl hydrocarbon receptor 2	Danio rerio	124-128
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	172-178	aryl hydrocarbon receptor	Homo sapiens	58-61
23959649-8	2013	Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels.	Dioxins	172-178	hematopoietic prostaglandin D synthase	Homo sapiens	73-77
23419585-3	2013	PCB congeners were summed separately for dioxin-like and nondioxin-like PCBs; the former were weighted for toxic equivalent factors.	Dioxins	41-47	pyruvate carboxylase	Homo sapiens	0-3
23491026-6	2013	Using the optimization approach to construct weighted quartile scores, the dioxin like PCB, the non-dioxin like PCB and metal class-level scores were significantly associated with elevated ALT.	Dioxins	75-81	pyruvate carboxylase	Homo sapiens	87-90
23636172-8	2013	Tissue factor expression and activity were also increased by AHR agonist dioxin.	Dioxins	73-79	coagulation factor III, tissue factor	Homo sapiens	0-13
23918665-4	2013	Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and 1B1 was provided.	Dioxins	86-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-158
23810773-1	2013	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands.	Dioxins	187-194	aryl hydrocarbon receptor	Homo sapiens	16-41
23810773-1	2013	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands.	Dioxins	187-194	aryl hydrocarbon receptor	Homo sapiens	43-46
23636172-8	2013	Tissue factor expression and activity were also increased by AHR agonist dioxin.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	61-64
23636172-11	2013	Thus, indolic uremic solutes increase tissue factor production in endothelial and peripheral blood mononuclear cells by AHR activation, evoking a "dioxin-like" effect.	Dioxins	147-153	coagulation factor III, tissue factor	Homo sapiens	38-51
23810773-14	2013	CONCLUSION: Our findings indicate that CCL5 is a target gene for AhR, and might be associated with the pathology of dioxin exposure.	Dioxins	116-122	C-C motif chemokine ligand 5	Homo sapiens	39-43
23810773-14	2013	CONCLUSION: Our findings indicate that CCL5 is a target gene for AhR, and might be associated with the pathology of dioxin exposure.	Dioxins	116-122	aryl hydrocarbon receptor	Homo sapiens	65-68
23636172-11	2013	Thus, indolic uremic solutes increase tissue factor production in endothelial and peripheral blood mononuclear cells by AHR activation, evoking a "dioxin-like" effect.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	120-123
23363321-1	2013	The aryl hydrocarbon receptor (AHR) is an intracellular transcription factor best known for mediating the toxicity of dioxins.	Dioxins	118-125	aryl hydrocarbon receptor	Homo sapiens	4-29
23363321-1	2013	The aryl hydrocarbon receptor (AHR) is an intracellular transcription factor best known for mediating the toxicity of dioxins.	Dioxins	118-125	aryl hydrocarbon receptor	Homo sapiens	31-34
24086407-3	2013	The destabilization of Cox-2 mRNA and subsequent suppression of cigarette smoke-induced COX-2 protein expression by the AhR was independent of its ability to bind the dioxin response element (DRE), thereby differentiating the DRE-driven toxicological AhR pathway from its anti-inflammatory abilities.	Dioxins	167-173	aryl hydrocarbon receptor	Homo sapiens	120-123
23612871-8	2013	Numerous environmental pollutants such as dioxins in soils and pesticides in foods have been successfully quantified using GC/MPI/TOF-MS, and this technique has proven itself to be a useful and practical method for trace analysis.	Dioxins	42-49	mannose phosphate isomerase	Homo sapiens	126-129
23673379-2	2013	The aryl-hydrocarbon-receptor (AhR) reporter system was utilized to transport a dioxin-responsive-element (DRE) via an adenovirus vector into rat hepatoma (H4IIE) cells before each experiment; these DRE-H4IIE cells were utilized in the Ad-DR bioassay.	Dioxins	80-86	aryl hydrocarbon receptor	Rattus norvegicus	4-29
23828038-1	2013	Selective inhibitory crosstalk has been known to occur within the signaling pathways of the dioxin (AhR) and estrogen (ERalpha) receptors.	Dioxins	92-98	aryl hydrocarbon receptor	Homo sapiens	100-103
23908379-2	2013	Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR by endogenous and environmental factors has important physiologic effects, including the regulation of the immune response.	Dioxins	94-101	aryl hydrocarbon receptor	Homo sapiens	13-16
23908379-2	2013	Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR by endogenous and environmental factors has important physiologic effects, including the regulation of the immune response.	Dioxins	94-101	aryl hydrocarbon receptor	Homo sapiens	142-145
23770670-0	2013	Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).	Dioxins	40-46	aryl hydrocarbon receptor	Homo sapiens	0-25
23770670-0	2013	Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).	Dioxins	40-46	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	55-88
23770670-0	2013	Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).	Dioxins	40-46	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	90-95
23770670-0	2013	Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).	Dioxins	40-46	TCDD inducible poly(ADP-ribose) polymerase	Homo sapiens	204-210
23836658-4	2013	Although AhR was first identified to bind the xenobiotic compound dioxin, AhR is now known to bind a variety of natural exogenous (e.g., dietary) and endogenous ligands.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	9-12
23836658-4	2013	Although AhR was first identified to bind the xenobiotic compound dioxin, AhR is now known to bind a variety of natural exogenous (e.g., dietary) and endogenous ligands.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	74-77
23639626-0	2013	TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.	Dioxins	163-169	insulin-like growth factor binding protein 4	Rattus norvegicus	31-75
23639626-9	2013	The observations suggest that in 5L cells the Igfbp-4 gene may have got under the control of a promoter containing dioxin responsive element(s) leading to the induction of IGFBP-4 by TCDD.	Dioxins	115-121	insulin-like growth factor binding protein 4	Rattus norvegicus	46-53
23639626-9	2013	The observations suggest that in 5L cells the Igfbp-4 gene may have got under the control of a promoter containing dioxin responsive element(s) leading to the induction of IGFBP-4 by TCDD.	Dioxins	115-121	insulin-like growth factor binding protein 4	Rattus norvegicus	172-179
23648332-6	2013	AhR mediated dioxin-like transactivity was determined using the AhR luciferase reporter Hepa 1.12cR cell assay.	Dioxins	13-19	aryl-hydrocarbon receptor	Mus musculus	0-3
23648332-6	2013	AhR mediated dioxin-like transactivity was determined using the AhR luciferase reporter Hepa 1.12cR cell assay.	Dioxins	13-19	aryl-hydrocarbon receptor	Mus musculus	64-67
23628245-10	2013	Given specific assumptions, monitoring with 95% effectiveness to detect an incident of 1 contaminated farm at a dioxin concentration of 2 pg of toxic equivalents/g of fat [European Commission"s (EC) action level] costs $2.6 million per month.	Dioxins	112-118	FAT atypical cadherin 1	Homo sapiens	167-170
23628245-11	2013	At the same level of effectiveness, a 73% cost reduction is possible when aiming to detect an incident where 2 farms are contaminated at a dioxin concentration of 3 pg of toxic equivalents/g of fat (EC maximum level).	Dioxins	139-145	FAT atypical cadherin 1	Homo sapiens	194-197
22388733-1	2013	The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression.	Dioxins	109-116	aryl hydrocarbon receptor	Homo sapiens	4-7
23692925-1	2013	Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics.	Dioxins	5-11	NAD(P)H dehydrogenase, quinone 1	Mus musculus	66-70
23692925-1	2013	Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics.	Dioxins	5-11	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	100-106
23692925-1	2013	Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics.	Dioxins	5-11	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	108-114
23528250-1	2013	Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR).	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	27-52
23528250-1	2013	Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR).	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-58
23528250-1	2013	Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	68-97
23528250-1	2013	Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	99-102
23528250-8	2013	Thus, polymorphisms in AHR and CYP1A1 (rs4646903) were associated with maternal dioxin concentrations.	Dioxins	80-86	aryl hydrocarbon receptor	Homo sapiens	23-26
23528250-8	2013	Thus, polymorphisms in AHR and CYP1A1 (rs4646903) were associated with maternal dioxin concentrations.	Dioxins	80-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
23500078-1	2013	BACKGROUND: Selenium-binding protein 1 (Selenbp1) is suggested to play a role in tumor suppression, and may be involved in the toxicity produced by dioxin, an activator of aryl hydrocarbon receptors (AhR).	Dioxins	148-154	selenium binding protein 1	Mus musculus	12-38
23500078-1	2013	BACKGROUND: Selenium-binding protein 1 (Selenbp1) is suggested to play a role in tumor suppression, and may be involved in the toxicity produced by dioxin, an activator of aryl hydrocarbon receptors (AhR).	Dioxins	148-154	selenium binding protein 1	Mus musculus	40-48
23500078-1	2013	BACKGROUND: Selenium-binding protein 1 (Selenbp1) is suggested to play a role in tumor suppression, and may be involved in the toxicity produced by dioxin, an activator of aryl hydrocarbon receptors (AhR).	Dioxins	148-154	aryl-hydrocarbon receptor	Mus musculus	172-198
23500078-1	2013	BACKGROUND: Selenium-binding protein 1 (Selenbp1) is suggested to play a role in tumor suppression, and may be involved in the toxicity produced by dioxin, an activator of aryl hydrocarbon receptors (AhR).	Dioxins	148-154	aryl-hydrocarbon receptor	Mus musculus	200-203
23370907-0	2013	The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions.	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	10-21
23370907-1	2013	Marked species differences of dioxin toxicity prompted the review of three well-studied human dioxin toxicities (chloracne, inflammation and cancer) and deregulated Ah receptor (AhR) target genes to obtain hints as to the physiological functions of this receptor.	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	165-176
23370907-1	2013	Marked species differences of dioxin toxicity prompted the review of three well-studied human dioxin toxicities (chloracne, inflammation and cancer) and deregulated Ah receptor (AhR) target genes to obtain hints as to the physiological functions of this receptor.	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	178-181
23370907-3	2013	Microarray analysis of dermal cysts from a dioxin-poisoned patient revealed, in addition to induced CYP1A1, increased expression of gremlin, an antagonist of bone morphogenetic proteins.	Dioxins	43-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
23370907-3	2013	Microarray analysis of dermal cysts from a dioxin-poisoned patient revealed, in addition to induced CYP1A1, increased expression of gremlin, an antagonist of bone morphogenetic proteins.	Dioxins	43-49	gremlin 1, DAN family BMP antagonist	Homo sapiens	132-139
23370907-5	2013	In the supernatant of CD4+ T cells obtained from the dioxin-poisoned patient, increased interleukin-22 was detected, a cytokine that may be controlled in part by AhR-regulated Notch.	Dioxins	53-59	interleukin 22	Homo sapiens	88-102
23370907-5	2013	In the supernatant of CD4+ T cells obtained from the dioxin-poisoned patient, increased interleukin-22 was detected, a cytokine that may be controlled in part by AhR-regulated Notch.	Dioxins	53-59	aryl hydrocarbon receptor	Homo sapiens	162-165
23745732-8	2013	Recently, it has been shown that activation of the AhR by dioxin-like compounds suppresses allergic sensitization by suppressing the absolute number of precursor and effector T cells, by preserving CD4(+)CD25(+)Foxp3(+) Treg cells and by affecting DCs and their interaction with effector T cells.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	51-54
23745732-8	2013	Recently, it has been shown that activation of the AhR by dioxin-like compounds suppresses allergic sensitization by suppressing the absolute number of precursor and effector T cells, by preserving CD4(+)CD25(+)Foxp3(+) Treg cells and by affecting DCs and their interaction with effector T cells.	Dioxins	58-64	CD4 molecule	Homo sapiens	198-201
23519780-1	2013	Novel methods that predict the sensitivity of avian embryos to the toxic effects of dioxin-like compounds (DLCs) using either (1) knowledge of the identity of amino acids at key sites within the ligand binding domain of aryl hydrocarbon receptor 1 (AHR1) or (2) a luciferase reporter gene assay that measures AHR1 activation were recently reported.	Dioxins	84-90	aryl hydrocarbon receptor	Sturnus vulgaris	220-247
23462309-2	2013	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	54-79
23462309-2	2013	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR).	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	81-84
24035824-3	2013	This study characterizes TCDD-induced modulations of bone tissue, and the role of AHR in dioxin-induced bone toxicity and for normal bone phenotype.	Dioxins	89-95	aryl-hydrocarbon receptor	Mus musculus	82-85
23448877-7	2013	Indirubin- and FICZ-activated AhR in HaCaT and human HepG2 cells with significantly higher, yet transient, potency as compared with the prototypical AhR ligand, dioxin.	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	30-33
23448877-7	2013	Indirubin- and FICZ-activated AhR in HaCaT and human HepG2 cells with significantly higher, yet transient, potency as compared with the prototypical AhR ligand, dioxin.	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	149-152
22388733-1	2013	The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression.	Dioxins	109-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-174
22388733-1	2013	The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression.	Dioxins	109-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	176-180
23587668-0	2013	Cyp1a reporter zebrafish reveals target tissues for dioxin.	Dioxins	52-58	cytochrome P450, family 1, subfamily A	Danio rerio	0-5
23692925-1	2013	Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics.	Dioxins	5-11	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	121-127
23528250-0	2013	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.	Dioxins	145-151	aryl hydrocarbon receptor	Homo sapiens	23-52
23528250-0	2013	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.	Dioxins	145-151	aryl hydrocarbon receptor	Homo sapiens	54-57
23528250-0	2013	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.	Dioxins	145-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-116
23528250-0	2013	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.	Dioxins	145-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
23426015-0	2013	AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	0-3
23426015-0	2013	AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro.	Dioxins	24-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
23426015-5	2013	METHODS: We used SK-N-SH human-derived neuronal cells to evaluate the effect of dioxin exposure on AChE.	Dioxins	80-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
23426015-7	2013	We also found that, unlike organophosphate pesticides that directly act on the catalytic center of AChE, the suppressive effect of dioxin was through transcriptional regulation.	Dioxins	131-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
23426015-9	2013	The existence of putative dioxin-responsive element (DRE) consensus sequences in the human ACHE promoter region further supported this hypothesis.	Dioxins	26-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
23426015-11	2013	CONCLUSIONS: In SK-N-SH cells, dioxin suppressed the activity of neuronal AChE via AhR-mediated transcriptional down-regulation.	Dioxins	31-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
23426015-11	2013	CONCLUSIONS: In SK-N-SH cells, dioxin suppressed the activity of neuronal AChE via AhR-mediated transcriptional down-regulation.	Dioxins	31-37	aryl hydrocarbon receptor	Homo sapiens	83-86
23240617-1	2013	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and serves multiple developmental roles.	Dioxins	109-115	aryl-hydrocarbon receptor	Mus musculus	4-29
23240617-1	2013	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and serves multiple developmental roles.	Dioxins	109-115	aryl-hydrocarbon receptor	Mus musculus	31-34
23193992-4	2013	Upon binding to dioxin, aryl hydrocarbon receptor (AHR) dissociates from HSP90 and subsequently translocates to the nucleus, where it interacts with AHR nuclear translocator (ARNT).	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	24-49
23193992-4	2013	Upon binding to dioxin, aryl hydrocarbon receptor (AHR) dissociates from HSP90 and subsequently translocates to the nucleus, where it interacts with AHR nuclear translocator (ARNT).	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	51-54
23193992-4	2013	Upon binding to dioxin, aryl hydrocarbon receptor (AHR) dissociates from HSP90 and subsequently translocates to the nucleus, where it interacts with AHR nuclear translocator (ARNT).	Dioxins	16-22	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
23193992-4	2013	Upon binding to dioxin, aryl hydrocarbon receptor (AHR) dissociates from HSP90 and subsequently translocates to the nucleus, where it interacts with AHR nuclear translocator (ARNT).	Dioxins	16-22	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	149-173
23193992-4	2013	Upon binding to dioxin, aryl hydrocarbon receptor (AHR) dissociates from HSP90 and subsequently translocates to the nucleus, where it interacts with AHR nuclear translocator (ARNT).	Dioxins	16-22	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	175-179
23673379-2	2013	The aryl-hydrocarbon-receptor (AhR) reporter system was utilized to transport a dioxin-responsive-element (DRE) via an adenovirus vector into rat hepatoma (H4IIE) cells before each experiment; these DRE-H4IIE cells were utilized in the Ad-DR bioassay.	Dioxins	80-86	aryl hydrocarbon receptor	Rattus norvegicus	31-34
23263608-1	2013	The aryl hydrocarbon receptor (AHR), which has been central to studies in toxicology for years as the receptor for the toxicant dioxin, is rapidly gaining interest in immunology based on its ability to influence T-cell differentiation.	Dioxins	128-134	aryl hydrocarbon receptor	Homo sapiens	4-29
23263608-1	2013	The aryl hydrocarbon receptor (AHR), which has been central to studies in toxicology for years as the receptor for the toxicant dioxin, is rapidly gaining interest in immunology based on its ability to influence T-cell differentiation.	Dioxins	128-134	aryl hydrocarbon receptor	Homo sapiens	31-34
23564762-2	2013	PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis.	Dioxins	9-16	aryl hydrocarbon receptor	Homo sapiens	65-90
23500661-0	2013	Association between exposure to dioxin-like polychlorinated biphenyls and miR-191 expression in human peripheral blood mononuclear cells.	Dioxins	32-38	microRNA 191	Homo sapiens	74-81
23500661-4	2013	miR-191 is a microRNA that has been found to be up-regulated by dioxin in hepatocellular carcinoma cells in vitro.	Dioxins	64-70	microRNA 191	Homo sapiens	0-7
23454571-0	2013	Modulation of aryl hydrocarbon receptor target genes in circulating lymphocytes from dairy cows bred in a dioxin-like PCB contaminated area.	Dioxins	106-112	LOC522736	Bos taurus	14-39
23564762-2	2013	PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis.	Dioxins	9-16	aryl hydrocarbon receptor	Homo sapiens	92-95
23168330-0	2013	Genetic susceptibility to dioxin-like chemicals" induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism.	Dioxins	26-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-80
23249762-9	2013	CONCLUSION: Our findings support a predominant role of CYP2B6 in the metabolism of BDE-47 to potentially toxic metabolites, including a hypothesized di-OH-tetrabrominated dioxin metabolite.	Dioxins	171-177	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	55-61
23249762-9	2013	CONCLUSION: Our findings support a predominant role of CYP2B6 in the metabolism of BDE-47 to potentially toxic metabolites, including a hypothesized di-OH-tetrabrominated dioxin metabolite.	Dioxins	171-177	homeobox D13	Homo sapiens	83-86
23394719-0	2013	Specific ligand binding domain residues confer low dioxin responsiveness to AHR1beta of Xenopus laevis.	Dioxins	51-57	aryl hydrocarbon receptor S homeolog	Xenopus laevis	76-84
23168330-1	2013	BACKGROUND: Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes.	Dioxins	197-203	aryl hydrocarbon receptor	Homo sapiens	80-105
23168330-1	2013	BACKGROUND: Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes.	Dioxins	197-203	aryl hydrocarbon receptor	Homo sapiens	107-110
23168330-0	2013	Genetic susceptibility to dioxin-like chemicals" induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism.	Dioxins	26-32	aryl hydrocarbon receptor repressor	Homo sapiens	119-123
23168330-2	2013	In a previous study of the Yucheng cohort of humans who were exposed to high toxic levels of dioxin-like chemicals (PCDFs and PCBs), we reported marked induction of cytochrome P450 1A2 (CYP1A2) activity and this induction was an excellent biomarker of the exposure and adverse human health effects seen in the Yucheng cohort.	Dioxins	93-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	165-184
23168330-1	2013	BACKGROUND: Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	80-105
23168330-2	2013	In a previous study of the Yucheng cohort of humans who were exposed to high toxic levels of dioxin-like chemicals (PCDFs and PCBs), we reported marked induction of cytochrome P450 1A2 (CYP1A2) activity and this induction was an excellent biomarker of the exposure and adverse human health effects seen in the Yucheng cohort.	Dioxins	93-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	186-192
23168330-8	2013	CONCLUSION: Overall, AhRR (rs2292596) genotypes predict the inducibility of CYP1A2 in people highly exposed to toxic dioxin-like chemicals.	Dioxins	117-123	aryl hydrocarbon receptor repressor	Homo sapiens	21-25
23168330-1	2013	BACKGROUND: Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	107-110
23168330-8	2013	CONCLUSION: Overall, AhRR (rs2292596) genotypes predict the inducibility of CYP1A2 in people highly exposed to toxic dioxin-like chemicals.	Dioxins	117-123	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
23333656-0	2013	Toxicokinetics of dioxins and other organochlorine compounds in Japanese people: association with hepatic CYP1A2 expression levels.	Dioxins	18-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	106-112
23193992-8	2013	In addition, dioxin treatment reduced Renilla luminescence in AAPH cells in a concentration-dependent manner, due to the degradation of AHR.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	136-139
23193992-9	2013	Intriguingly, the detection limit for dioxin in our AHR degradation assay was as low as 10(-17) M. This work highlights the potential of AHR-RL degradation assays to detect dioxin-like pollutants.	Dioxins	38-44	aryl hydrocarbon receptor	Homo sapiens	52-55
23193992-9	2013	Intriguingly, the detection limit for dioxin in our AHR degradation assay was as low as 10(-17) M. This work highlights the potential of AHR-RL degradation assays to detect dioxin-like pollutants.	Dioxins	38-44	aryl hydrocarbon receptor	Homo sapiens	137-140
23193992-9	2013	Intriguingly, the detection limit for dioxin in our AHR degradation assay was as low as 10(-17) M. This work highlights the potential of AHR-RL degradation assays to detect dioxin-like pollutants.	Dioxins	173-179	aryl hydrocarbon receptor	Homo sapiens	52-55
23193992-9	2013	Intriguingly, the detection limit for dioxin in our AHR degradation assay was as low as 10(-17) M. This work highlights the potential of AHR-RL degradation assays to detect dioxin-like pollutants.	Dioxins	173-179	aryl hydrocarbon receptor	Homo sapiens	137-140
23168330-1	2013	BACKGROUND: Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes.	Dioxins	12-18	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	175-179
23032644-14	2012	These models underline the value of dietary intake data for use in investigations of associations between dioxin and PCB exposure and health outcomes in large epidemiological studies with limited biomaterial for chemical analysis.	Dioxins	106-112	pyruvate carboxylase	Homo sapiens	117-120
23391895-6	2013	A majority of residents believed that dioxins can be found in river water that has been filtered to completely remove all particulates, well water, and even city tap water, beliefs which are incongruous with the hydrophobic nature of dioxins.	Dioxins	38-45	nuclear RNA export factor 1	Homo sapiens	162-165
23081912-0	2013	Fungicide prochloraz and environmental pollutant dioxin induce the ABCG2 transporter in bovine mammary epithelial cells by the arylhydrocarbon receptor signaling pathway.	Dioxins	49-55	ATP binding cassette subfamily G member 2	Bos taurus	67-72
23081912-2	2013	Using computer analysis, we recently identified nuclear aryl hydrocarbon receptor (AhR) binding sites termed "dioxin response elements" (DREs) in the 5"-untranslated region (5"-UTR) of efflux transporter ABCG2 (Accession No.	Dioxins	110-116	LOC522736	Bos taurus	56-81
23081912-2	2013	Using computer analysis, we recently identified nuclear aryl hydrocarbon receptor (AhR) binding sites termed "dioxin response elements" (DREs) in the 5"-untranslated region (5"-UTR) of efflux transporter ABCG2 (Accession No.	Dioxins	110-116	LOC522736	Bos taurus	83-86
23081912-2	2013	Using computer analysis, we recently identified nuclear aryl hydrocarbon receptor (AhR) binding sites termed "dioxin response elements" (DREs) in the 5"-untranslated region (5"-UTR) of efflux transporter ABCG2 (Accession No.	Dioxins	110-116	ATP binding cassette subfamily G member 2	Bos taurus	204-209
23036853-0	2013	Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-103
23441220-1	2013	Activation of the Ah receptor (AhR) by halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), can produce a wide variety of toxic and biological effects.	Dioxins	118-124	aryl hydrocarbon receptor	Homo sapiens	31-34
23081912-11	2013	Through identification of mammary ABCG2 as a novel target gene of pesticide prochloraz and dioxin, our results may therefore help to improve the protection of breast-feeding infants and the consumer of dairy products.	Dioxins	91-97	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-39
23142599-3	2013	To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost.	Dioxins	157-163	vitellogenin	Danio rerio	41-53
23142599-3	2013	To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost.	Dioxins	157-163	aryl hydrocarbon receptor 2	Danio rerio	119-146
23142599-3	2013	To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost.	Dioxins	157-163	aryl hydrocarbon receptor 2	Danio rerio	148-152
23142599-3	2013	To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost.	Dioxins	157-163	vitellogenin	Danio rerio	219-231
23060366-10	2013	RESULTS: After accounting for multiple testing, two tag SNPs in the glucocorticoid receptor (GR/NR3C1) gene and one in the estrogen receptor-alpha (ESR1) gene were significant (q < 0.2) modifiers of the association between peripubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although not by testicular volume.	Dioxins	245-251	nuclear receptor subfamily 3 group C member 1	Homo sapiens	68-91
23060366-10	2013	RESULTS: After accounting for multiple testing, two tag SNPs in the glucocorticoid receptor (GR/NR3C1) gene and one in the estrogen receptor-alpha (ESR1) gene were significant (q < 0.2) modifiers of the association between peripubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although not by testicular volume.	Dioxins	245-251	nuclear receptor subfamily 3 group C member 1	Homo sapiens	96-101
23060366-10	2013	RESULTS: After accounting for multiple testing, two tag SNPs in the glucocorticoid receptor (GR/NR3C1) gene and one in the estrogen receptor-alpha (ESR1) gene were significant (q < 0.2) modifiers of the association between peripubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although not by testicular volume.	Dioxins	245-251	estrogen receptor 1	Homo sapiens	123-146
23060366-10	2013	RESULTS: After accounting for multiple testing, two tag SNPs in the glucocorticoid receptor (GR/NR3C1) gene and one in the estrogen receptor-alpha (ESR1) gene were significant (q < 0.2) modifiers of the association between peripubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although not by testicular volume.	Dioxins	245-251	estrogen receptor 1	Homo sapiens	148-152
23060366-12	2013	CONCLUSIONS: Common genetic polymorphisms in the glucocorticoid receptor and estrogen receptor-alpha genes may modify the association between peripubertal serum dioxin concentration and pubertal onset.	Dioxins	161-167	nuclear receptor subfamily 3 group C member 1	Homo sapiens	49-72
23060366-12	2013	CONCLUSIONS: Common genetic polymorphisms in the glucocorticoid receptor and estrogen receptor-alpha genes may modify the association between peripubertal serum dioxin concentration and pubertal onset.	Dioxins	161-167	estrogen receptor 1	Homo sapiens	77-100
24454361-1	2013	The aryl-hydrocarbon receptor (AHR), a ligand activated PAS superfamily transcription factor, mediates most, if not all, of the toxicity induced upon exposure to various dioxins, dibenzofurans, and planar polyhalogenated biphenyls.	Dioxins	170-177	aryl hydrocarbon receptor	Homo sapiens	4-29
24454361-1	2013	The aryl-hydrocarbon receptor (AHR), a ligand activated PAS superfamily transcription factor, mediates most, if not all, of the toxicity induced upon exposure to various dioxins, dibenzofurans, and planar polyhalogenated biphenyls.	Dioxins	170-177	aryl hydrocarbon receptor	Homo sapiens	31-34
24454361-2	2013	While AHR-mediated gene regulation plays a central role in the toxic response to dioxin exposure, a comprehensive understanding of AHR biology remains elusive.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	6-9
23121134-2	2013	The structural similarity of PBDE to some dioxin-like compounds suggested that they may share similar toxicological effects: they might activate the aryl hydrocarbon receptor (AhR) signal transduction pathway and thus might have adverse effects on wildlife and humans.	Dioxins	42-48	aryl hydrocarbon receptor	Homo sapiens	149-174
23121134-2	2013	The structural similarity of PBDE to some dioxin-like compounds suggested that they may share similar toxicological effects: they might activate the aryl hydrocarbon receptor (AhR) signal transduction pathway and thus might have adverse effects on wildlife and humans.	Dioxins	42-48	aryl hydrocarbon receptor	Homo sapiens	176-179
23142756-5	2013	The goals of the present study were to (1) characterize the concentration-dependent effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and PCBs 126, 77, 105 and 118 on induction of ethoxyresorufin O-deethylase (EROD) activity and CYP1A4/5 mRNA in chicken, ring-necked pheasant and Japanese quail embryo hepatocytes and (2) compare these in vitro results to those previously generated by the LRG assay and in ovo toxicity studies.	Dioxins	124-130	cytochrome P450 1A4	Gallus gallus	226-232
22982498-11	2012	Given that the Per-AhR/Arnt-Sim homology sequence of transcription factors usually associate with each other to form heterodimers and bind the XRE or ERE sequences in the promoter regions of target genes to regulate their expression, the complete mechanism of interactions between dioxin-like and estrogenic compounds in vertebrate systems may require additional characterization.	Dioxins	281-287	aryl hydrocarbon receptor	Homo sapiens	19-22
22982498-11	2012	Given that the Per-AhR/Arnt-Sim homology sequence of transcription factors usually associate with each other to form heterodimers and bind the XRE or ERE sequences in the promoter regions of target genes to regulate their expression, the complete mechanism of interactions between dioxin-like and estrogenic compounds in vertebrate systems may require additional characterization.	Dioxins	281-287	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	23-27
22975028-4	2012	Because of the link between AIP and pituitary tumors, we hypothesize that exposure to dioxins, potent exogenous ligands for AhR that are persistent in the environment, may predispose to pituitary dysfunction through activation of AhR.	Dioxins	86-93	aryl hydrocarbon receptor	Rattus norvegicus	124-127
22858370-2	2012	The toxicological effects of dioxins are mediated via the aryl hydrocarbon receptor (AhR).	Dioxins	29-36	aryl hydrocarbon receptor	Homo sapiens	58-83
22858370-2	2012	The toxicological effects of dioxins are mediated via the aryl hydrocarbon receptor (AhR).	Dioxins	29-36	aryl hydrocarbon receptor	Homo sapiens	85-88
22750796-4	2012	The pooled samples were analysed for 17 PCDD/Fs and 36 PCB congeners, and from these data, total toxic equivalent concentrations (TEQ(2005 PCDD/F+Dioxin-like [DL]-PCB)) were estimated.	Dioxins	146-152	pyruvate carboxylase	Homo sapiens	163-166
22634562-2	2012	3-Methylcholanthrene (3-MC) and dioxin (TCDD) are EDCs and prototypical aryl hydrocarbon receptor (AhR) agonists, and can inhibit ER signaling.	Dioxins	32-38	aryl hydrocarbon receptor	Homo sapiens	72-97
22634562-2	2012	3-Methylcholanthrene (3-MC) and dioxin (TCDD) are EDCs and prototypical aryl hydrocarbon receptor (AhR) agonists, and can inhibit ER signaling.	Dioxins	32-38	aryl hydrocarbon receptor	Homo sapiens	99-102
23026235-2	2012	AhR is ligand activated transcription factor with high affinities for aromatic planar compounds such as beta-naphthoflavone (BNF), 3-methylcholanthrene (3-MC), benzo[a]pyrene (BaP) or dioxin (TCDD).	Dioxins	184-190	aryl hydrocarbon receptor	Rattus norvegicus	0-3
22564984-5	2012	A negative relationship remained between PCB 118 and SHBG (p<0.01), and relationships of dioxin-like PCBs with SHBG and total testosterone, and between PCB 118 and total testosterone, were suggestive.	Dioxins	92-98	sex hormone binding globulin	Homo sapiens	114-118
22564984-5	2012	A negative relationship remained between PCB 118 and SHBG (p<0.01), and relationships of dioxin-like PCBs with SHBG and total testosterone, and between PCB 118 and total testosterone, were suggestive.	Dioxins	92-98	pyruvate carboxylase	Homo sapiens	104-107
23905062-6	2012	It has been inferred an overexpression of the mir-191 as a marker of pollution by dioxin-like compounds.	Dioxins	82-88	microRNA 191	Homo sapiens	46-53
22659940-1	2012	The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin.	Dioxins	112-118	aryl hydrocarbon receptor	Rattus norvegicus	4-29
22659940-1	2012	The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin.	Dioxins	112-118	aryl hydrocarbon receptor	Rattus norvegicus	31-34
22975028-4	2012	Because of the link between AIP and pituitary tumors, we hypothesize that exposure to dioxins, potent exogenous ligands for AhR that are persistent in the environment, may predispose to pituitary dysfunction through activation of AhR.	Dioxins	86-93	aryl hydrocarbon receptor	Rattus norvegicus	230-233
22975028-11	2012	Overall, these results demonstrate that AhR is important for pituitary hormone expression and suggest that environmental dioxins can exert endocrine disrupting effects at the pituitary.	Dioxins	121-128	aryl hydrocarbon receptor	Rattus norvegicus	40-43
22978700-0	2012	Aryl hydrocarbon receptor-dependence of dioxin"s effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components.	Dioxins	40-46	aryl-hydrocarbon receptor	Mus musculus	0-25
22978700-0	2012	Aryl hydrocarbon receptor-dependence of dioxin"s effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components.	Dioxins	40-46	growth hormone	Mus musculus	108-122
22197621-3	2012	AhR-ligands include the dioxin-like and tumor promoter 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	0-3
22664790-0	2012	The androgenic anabolic steroid tetrahydrogestrinone produces dioxin-like effects via the aryl hydrocarbon receptor.	Dioxins	62-68	aryl hydrocarbon receptor	Homo sapiens	90-115
22889882-0	2012	Dioxin exposure reduces the steroidogenic capacity of mouse antral follicles mainly at the level of HSD17B1 without altering atresia.	Dioxins	0-6	hydroxysteroid (17-beta) dehydrogenase 1	Mus musculus	100-107
22820424-2	2012	As an aryl hydrocarbon receptor (AhR) ligand, baicalein at high concentrations blocks AhR-mediated dioxin toxicity.	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	33-36
22820424-2	2012	As an aryl hydrocarbon receptor (AhR) ligand, baicalein at high concentrations blocks AhR-mediated dioxin toxicity.	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	86-89
22553215-2	2012	These effects are observed to occur through an AHR-dependent mechanism that does not require canonical signaling through dioxin response elements.	Dioxins	121-127	aryl hydrocarbon receptor	Homo sapiens	47-50
22784254-0	2012	Serum from methimazole-treated patients induces activation of aryl hydrocarbon receptor, a transcription factor that binds to dioxin-response elements.	Dioxins	126-132	aryl hydrocarbon receptor	Homo sapiens	62-87
22784254-1	2012	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by xenobiotic substances such as dioxin.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	16-41
22784254-1	2012	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by xenobiotic substances such as dioxin.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	43-46
22534176-1	2012	BACKGROUND: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; however, downstream signaling events that link enhanced RyR activity to dendritic growth are unknown.	Dioxins	16-22	ryanodine receptor 2	Rattus norvegicus	119-137
22534176-1	2012	BACKGROUND: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; however, downstream signaling events that link enhanced RyR activity to dendritic growth are unknown.	Dioxins	16-22	ryanodine receptor 2	Rattus norvegicus	139-142
22534176-1	2012	BACKGROUND: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; however, downstream signaling events that link enhanced RyR activity to dendritic growth are unknown.	Dioxins	16-22	ryanodine receptor 2	Rattus norvegicus	222-225
22871890-6	2012	In transfected CTSL1 promoter/luciferase reporter plasmids, C-171A allele influenced transcription (C>A, P = 3.36E-6), and transcription was also augmented by co-exposure to the aryl hydrocarbon receptor (AHR) complex (AHR:ARNT) in the presence of their ligand dioxin (P = 6.81E-8); allele (C vs. A) and AHR:ARNT/dioxin stimulus interacted to control gene expression (interaction P = 0.033).	Dioxins	264-270	cathepsin L	Homo sapiens	15-20
22871890-6	2012	In transfected CTSL1 promoter/luciferase reporter plasmids, C-171A allele influenced transcription (C>A, P = 3.36E-6), and transcription was also augmented by co-exposure to the aryl hydrocarbon receptor (AHR) complex (AHR:ARNT) in the presence of their ligand dioxin (P = 6.81E-8); allele (C vs. A) and AHR:ARNT/dioxin stimulus interacted to control gene expression (interaction P = 0.033).	Dioxins	264-270	aryl hydrocarbon receptor	Homo sapiens	181-206
22871890-6	2012	In transfected CTSL1 promoter/luciferase reporter plasmids, C-171A allele influenced transcription (C>A, P = 3.36E-6), and transcription was also augmented by co-exposure to the aryl hydrocarbon receptor (AHR) complex (AHR:ARNT) in the presence of their ligand dioxin (P = 6.81E-8); allele (C vs. A) and AHR:ARNT/dioxin stimulus interacted to control gene expression (interaction P = 0.033).	Dioxins	316-322	cathepsin L	Homo sapiens	15-20
22871890-6	2012	In transfected CTSL1 promoter/luciferase reporter plasmids, C-171A allele influenced transcription (C>A, P = 3.36E-6), and transcription was also augmented by co-exposure to the aryl hydrocarbon receptor (AHR) complex (AHR:ARNT) in the presence of their ligand dioxin (P = 6.81E-8); allele (C vs. A) and AHR:ARNT/dioxin stimulus interacted to control gene expression (interaction P = 0.033).	Dioxins	316-322	aryl hydrocarbon receptor	Homo sapiens	181-206
22842592-1	2012	In this work, a reliable methodology for the simultaneous analysis of PCDD/PCDF and dioxin-like PCB (dl-PCB) in flue gas emissions collected using continuous sampling devices is proposed.	Dioxins	84-90	pyruvate carboxylase	Homo sapiens	96-99
22842592-1	2012	In this work, a reliable methodology for the simultaneous analysis of PCDD/PCDF and dioxin-like PCB (dl-PCB) in flue gas emissions collected using continuous sampling devices is proposed.	Dioxins	84-90	pyruvate carboxylase	Homo sapiens	104-107
22759865-1	2012	The aryl hydrocarbon receptor (AhR) is a ligand-sensitive transcription factor which is responsible for most 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicities.	Dioxins	138-144	aryl hydrocarbon receptor	Homo sapiens	4-29
22759865-1	2012	The aryl hydrocarbon receptor (AhR) is a ligand-sensitive transcription factor which is responsible for most 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicities.	Dioxins	138-144	aryl hydrocarbon receptor	Homo sapiens	31-34
22652426-0	2012	A dioxin response element in the multiple cloning site of the pGL3 luciferase reporter influences transcriptional activity.	Dioxins	2-8	succinate dehydrogenase complex subunit C	Homo sapiens	62-66
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	132-138	aryl hydrocarbon receptor	Homo sapiens	33-36
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	132-138	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	66-90
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	132-138	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	92-96
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	189-195	aryl hydrocarbon receptor	Homo sapiens	33-36
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	189-195	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	66-90
22652426-2	2012	Following ligand activation, the AhR and its dimerization partner AhR nuclear translocator (ARNT) regulate transcription by binding dioxin response elements (DREs) in regulatory regions of dioxin-sensitive genes.	Dioxins	189-195	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	92-96
22371237-5	2012	The meeting highlighted that AhR research has moved from its focus on toxic effects of dioxins and other environmental pollutants to its biological roles.	Dioxins	87-94	aryl hydrocarbon receptor	Homo sapiens	29-32
22539624-9	2012	In addition, computational scanning identified putative dioxin response elements and in vivo ChIP-chip analysis revealed regions of aryl hydrocarbon receptor (AhR) enrichment in lipid transport genes differentially regulated by TCDD.	Dioxins	56-62	aryl-hydrocarbon receptor	Mus musculus	132-157
22539624-9	2012	In addition, computational scanning identified putative dioxin response elements and in vivo ChIP-chip analysis revealed regions of aryl hydrocarbon receptor (AhR) enrichment in lipid transport genes differentially regulated by TCDD.	Dioxins	56-62	aryl-hydrocarbon receptor	Mus musculus	159-162
22507882-2	2012	Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands.	Dioxins	104-111	aryl hydrocarbon receptor	Homo sapiens	18-21
22664790-8	2012	Our results suggest that synthetic anabolic steroids may have dioxin-like side effects that can disturb endocrine systems and may cause other side effects including cancer through AhR.	Dioxins	62-68	aryl hydrocarbon receptor	Homo sapiens	180-183
22491429-0	2012	Non-dioxin-like AhR ligands in a mouse peanut allergy model.	Dioxins	4-10	aryl-hydrocarbon receptor	Mus musculus	16-19
22471748-1	2012	The aryl hydrocarbon receptor (AHR) mediates toxic effects of dioxin and xenobiotic metabolism.	Dioxins	62-68	aryl hydrocarbon receptor	Rattus norvegicus	4-29
22471748-1	2012	The aryl hydrocarbon receptor (AHR) mediates toxic effects of dioxin and xenobiotic metabolism.	Dioxins	62-68	aryl hydrocarbon receptor	Rattus norvegicus	31-34
22471748-11	2012	These data suggest considerable complexity in RBL2H3 responses to AHR ligands, with implications for understanding of both dioxin pathology and the immunological effects of endogenous AHR ligands.	Dioxins	123-129	aryl hydrocarbon receptor	Rattus norvegicus	66-69
22213127-11	2012	UGT1A transcriptional activation by dioxin, phenobarbital, and endotoxin was significantly reduced in SNP mice.	Dioxins	36-42	Ugt1a@	Mus musculus	0-5
22394336-3	2012	The toxic equivalency factors for higher chlorinated dioxin congeners in the TH assay (TH-TEF) exhibit the same tendency as those for the WHO-TEF, indicating that the activity of the TH assay is consistent with that of existing methods.	Dioxins	53-59	tyrosine hydroxylase	Homo sapiens	77-79
22394336-3	2012	The toxic equivalency factors for higher chlorinated dioxin congeners in the TH assay (TH-TEF) exhibit the same tendency as those for the WHO-TEF, indicating that the activity of the TH assay is consistent with that of existing methods.	Dioxins	53-59	tyrosine hydroxylase	Homo sapiens	87-89
22394336-3	2012	The toxic equivalency factors for higher chlorinated dioxin congeners in the TH assay (TH-TEF) exhibit the same tendency as those for the WHO-TEF, indicating that the activity of the TH assay is consistent with that of existing methods.	Dioxins	53-59	TEF transcription factor, PAR bZIP family member	Homo sapiens	90-93
22394336-3	2012	The toxic equivalency factors for higher chlorinated dioxin congeners in the TH assay (TH-TEF) exhibit the same tendency as those for the WHO-TEF, indicating that the activity of the TH assay is consistent with that of existing methods.	Dioxins	53-59	tyrosine hydroxylase	Homo sapiens	87-89
22234961-0	2012	Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner.	Dioxins	78-84	aryl-hydrocarbon receptor	Mus musculus	0-25
22234961-2	2012	Activation of AhR mediates the expression of target genes (e.g., CYP1A1) by binding to dioxin response element (DRE) sequences in their promoter region.	Dioxins	87-93	aryl-hydrocarbon receptor	Mus musculus	14-17
22234961-2	2012	Activation of AhR mediates the expression of target genes (e.g., CYP1A1) by binding to dioxin response element (DRE) sequences in their promoter region.	Dioxins	87-93	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	65-71
22653785-1	2012	The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin.	Dioxins	170-176	aryl hydrocarbon receptor	Homo sapiens	42-67
22430074-0	2012	Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.	Dioxins	111-117	prostaglandin E synthase	Mus musculus	17-54
23082663-1	2012	The indigenous people of coastal areas show a low percentage of low chlorinated and dioxin-like PCB congeners (as opposed to mainland aborigines) with a significant proportion of the "triad" in the amount of PCBs.	Dioxins	84-90	pyruvate carboxylase	Homo sapiens	96-99
22653785-1	2012	The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin.	Dioxins	170-176	aryl hydrocarbon receptor	Homo sapiens	69-72
22467650-1	2012	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates a variety of biological effects by binding to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin).	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	4-29
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	22-25
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	27-30
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	27-30
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	10-16	protein kinase C alpha	Homo sapiens	72-81
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	27-30
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	130-136	pyruvate carboxylase	Homo sapiens	22-25
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	130-136	pyruvate carboxylase	Homo sapiens	27-30
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	130-136	pyruvate carboxylase	Homo sapiens	27-30
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	130-136	protein kinase C alpha	Homo sapiens	72-81
24278597-7	2012	While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-alpha and -epsilon from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects.	Dioxins	130-136	pyruvate carboxylase	Homo sapiens	27-30
21958697-1	2012	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is a global environmental contaminant and the prototypical ligand for investigating aryl hydrocarbon receptor (AHR)-mediated toxicity.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	164-167
21958697-3	2012	To resolve the ecotoxicological relevance and human health risks posed by exposure to dioxin-like AHR agonists, a vertebrate model is needed that allows for toxicity studies at various levels of biological organization, assesses adverse reproductive and developmental effects and establishes appropriate integrative correlations between different levels of effects.	Dioxins	86-92	aryl hydrocarbon receptor	Homo sapiens	98-101
21958697-4	2012	Here we describe the reproductive and developmental toxicity of TCDD in feral fish species and summarize how using the zebrafish model to investigate TCDD toxicity has enabled us to characterize the AHR signaling in fish and to better understand how dioxin-like chemicals induce toxicity.	Dioxins	250-256	aryl hydrocarbon receptor	Homo sapiens	199-202
22344700-0	2012	p-Anilinoaniline enhancement of dioxin-induced CYP1A1 transcription and aryl hydrocarbon receptor occupancy of CYP1A1 promoter: role of the cell cycle.	Dioxins	32-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53
22407850-3	2012	Total PCB and dioxin-like PCB (DL-PCB) levels were not significantly different between wild-caught and farm-raised shrimp, and the distribution of total PCB levels did not vary considerably by country of origin although significant differences were observed in some cases.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
22407850-3	2012	Total PCB and dioxin-like PCB (DL-PCB) levels were not significantly different between wild-caught and farm-raised shrimp, and the distribution of total PCB levels did not vary considerably by country of origin although significant differences were observed in some cases.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
22407850-3	2012	Total PCB and dioxin-like PCB (DL-PCB) levels were not significantly different between wild-caught and farm-raised shrimp, and the distribution of total PCB levels did not vary considerably by country of origin although significant differences were observed in some cases.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
22467650-1	2012	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates a variety of biological effects by binding to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin).	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	31-34
22328528-0	2012	Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription.	Dioxins	113-119	estrogen receptor 1	Homo sapiens	15-22
22311706-1	2012	The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is known to regulate the toxicity of polyaromatic halogenated hydrocarbon environmental chemicals, most notably dioxin.	Dioxins	258-264	aryl hydrocarbon receptor	Homo sapiens	4-29
22311706-1	2012	The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is known to regulate the toxicity of polyaromatic halogenated hydrocarbon environmental chemicals, most notably dioxin.	Dioxins	258-264	aryl hydrocarbon receptor	Homo sapiens	31-34
22328528-0	2012	Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription.	Dioxins	113-119	nuclear receptor coactivator 1	Homo sapiens	63-67
22328528-0	2012	Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription.	Dioxins	113-119	nuclear receptor coactivator 1	Homo sapiens	76-80
22342509-8	2012	Using this uniquely consistent dataset, we show that the majority of TCDD-induced alterations in mRNA abundance are strain/line-specific: only 11 genes were affected by TCDD across all strains, including well-known dioxin-responsive genes such as Cyp1a1 and Nqo1.	Dioxins	215-221	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	247-253
22342509-8	2012	Using this uniquely consistent dataset, we show that the majority of TCDD-induced alterations in mRNA abundance are strain/line-specific: only 11 genes were affected by TCDD across all strains, including well-known dioxin-responsive genes such as Cyp1a1 and Nqo1.	Dioxins	215-221	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	258-262
22280929-9	2012	For the dioxin-like PCBs, PCB 118 was the dominant (0.97 ng/g lipid).	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
22476776-4	2012	AhRs are expressed in nearly every mammalian tissue, including the suprachiasmatic nuclei (SCN), and previous studies have suggested that activation of the AhR with dioxins affects rhythmicity in circadian clocks.	Dioxins	165-172	aryl hydrocarbon receptor	Homo sapiens	0-3
22394227-1	2012	UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins.	Dioxins	196-203	aryl hydrocarbon receptor	Homo sapiens	33-58
22394227-1	2012	UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins.	Dioxins	196-203	aryl hydrocarbon receptor	Homo sapiens	60-63
22476776-5	2012	In this study, the authors tested the hypothesis that activation of the aryl hydrocarbon receptor with the potent dioxin, TCDD, alters the organization of the mammalian circadian system by measuring bioluminescence from tissues explanted from PER2::LUCIFERASE mice.	Dioxins	114-120	aryl hydrocarbon receptor	Homo sapiens	72-97
22266287-1	2012	3,3",4,4",5-Pentachlorobiphenyl (PCB 126), an aryl hydrocarbon receptor (AhR) agonist and most potent dioxin-like PCB congener, significantly alters gene expression, lipid metabolism, and oxidative stress in the liver.	Dioxins	102-108	pyruvate carboxylase	Rattus norvegicus	33-36
22266287-8	2012	This study, the first describing the regulation of gene expression of PON1 by a PCB congener, raises interesting questions whether elevated PON1 is able to ameliorate PCB 126-induced lipid peroxidation and whether serum PON1 levels may serve as a new biomarker of exposure to dioxin-like compounds.	Dioxins	276-282	paraoxonase 1	Rattus norvegicus	70-74
21567390-2	2012	Since cigarette smoke (CS) contains numerous polycyclic aromatic hydrocarbons (PAHs), and since dioxins impair bone formation in vivo via the Aryl Hydrocarbon Receptor (AHR), we investigated the impact of PAH/AHR signaling on chondrogenesis and on healing in a mouse tibial fracture model.	Dioxins	96-103	aryl-hydrocarbon receptor	Mus musculus	169-172
22037238-1	2012	Dioxins are known to cause several human cancers through activation of the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	75-100
22037238-1	2012	Dioxins are known to cause several human cancers through activation of the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	102-105
22296185-0	2012	Sequence and in vitro function of chicken, ring-necked pheasant, and Japanese quail AHR1 predict in vivo sensitivity to dioxins.	Dioxins	120-127	aryl hydrocarbon receptor	Coturnix japonica	84-88
22037238-4	2012	Therefore, the aim of this study is to examine the effect of harmaline and its main metabolite, harmalol, on dioxin-mediated induction of CYP1A1 in human hepatoma HepG2 cells.	Dioxins	109-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-144
22037238-5	2012	Our results showed that harmaline and harmalol at concentrations of (0.5-12.5muM) significantly inhibited the dioxin-induced CYP1A1 at mRNA, protein and activity levels in a concentration-dependent manner.	Dioxins	110-116	latexin	Homo sapiens	77-80
22037238-5	2012	Our results showed that harmaline and harmalol at concentrations of (0.5-12.5muM) significantly inhibited the dioxin-induced CYP1A1 at mRNA, protein and activity levels in a concentration-dependent manner.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	125-131
22266287-1	2012	3,3",4,4",5-Pentachlorobiphenyl (PCB 126), an aryl hydrocarbon receptor (AhR) agonist and most potent dioxin-like PCB congener, significantly alters gene expression, lipid metabolism, and oxidative stress in the liver.	Dioxins	102-108	pyruvate carboxylase	Rattus norvegicus	114-117
22071320-7	2012	Changing the cellular level of RIP140 revealed coactivator or corepressor roles for this coregulator in E2- and dioxin-mediated gene regulation, the choice of which was determined by the presence or absence of ERalpha at gene regulatory sites.	Dioxins	112-118	nuclear receptor interacting protein 1	Homo sapiens	31-37
22215208-9	2012	Finally, KYNA has been reported as an agonist of aryl hydrocarbon receptor (AHR), a nuclear protein involved in the regulation of gene transcription and able to cause immunosuppression after binding with dioxin.	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	49-74
22215208-9	2012	Finally, KYNA has been reported as an agonist of aryl hydrocarbon receptor (AHR), a nuclear protein involved in the regulation of gene transcription and able to cause immunosuppression after binding with dioxin.	Dioxins	204-210	aryl hydrocarbon receptor	Homo sapiens	76-79
22071320-7	2012	Changing the cellular level of RIP140 revealed coactivator or corepressor roles for this coregulator in E2- and dioxin-mediated gene regulation, the choice of which was determined by the presence or absence of ERalpha at gene regulatory sites.	Dioxins	112-118	estrogen receptor 1	Homo sapiens	210-217
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	101-107	estrogen receptor 1	Homo sapiens	154-161
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	101-107	aryl hydrocarbon receptor	Homo sapiens	163-166
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	101-107	nuclear receptor interacting protein 1	Homo sapiens	172-178
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	101-107	estrogen receptor 1	Homo sapiens	182-189
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	239-245	estrogen receptor 1	Homo sapiens	154-161
22071320-8	2012	Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin.	Dioxins	239-245	nuclear receptor interacting protein 1	Homo sapiens	172-178
22718620-1	2012	The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways.	Dioxins	123-130	aryl hydrocarbon receptor	Homo sapiens	4-29
22718620-1	2012	The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways.	Dioxins	123-130	aryl hydrocarbon receptor	Homo sapiens	31-34
22001777-0	2012	Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.	Dioxins	52-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-87
22001777-1	2012	Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism.	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-115
22001777-1	2012	Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism.	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
22001777-1	2012	Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	136-161
22001777-1	2012	Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	163-166
22001777-2	2012	We previously demonstrated that harmine inhibits the dioxin-mediated induction of Cyp1a1 activity in murine hepatoma cells.	Dioxins	53-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
22001777-3	2012	Therefore, the aim of this study is to determine the effect of harmine and its main metabolite, harmol, on the dioxin-mediated induction of CYP1A1 in human HepG2 and murine Hepa 1c1c7 hepatoma cells.	Dioxins	111-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146
22001777-4	2012	Our results showed that harmine and harmol significantly inhibited the dioxin-mediated induction of CYP1A1 at mRNA, protein, and activity levels in a concentration-dependent manner in human and murine hepatoma cells.	Dioxins	71-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
22428884-1	2012	The transgenic tobacco plant XD4V-26 carrying the recombinant mouse aryl hydrocarbon receptor XD4V-mediated beta-glucuronidase (GUS) reporter gene expression system was used for assay of dioxins and dioxin-like compounds consisting of polychlorodibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls (Co-PCBs) in actually contaminated soils.	Dioxins	187-194	aryl-hydrocarbon receptor	Mus musculus	68-93
22185817-1	2012	Single nucleotide polymorphisms (SNPs) in genes coding for proteins that maintain the cytosolic aryl hydrocarbon receptor (AHR) complex may affect individual susceptibility to dioxin-like compound (DLC)-induced toxicity.	Dioxins	176-182	aryl hydrocarbon receptor	Homo sapiens	96-121
22185817-1	2012	Single nucleotide polymorphisms (SNPs) in genes coding for proteins that maintain the cytosolic aryl hydrocarbon receptor (AHR) complex may affect individual susceptibility to dioxin-like compound (DLC)-induced toxicity.	Dioxins	176-182	aryl hydrocarbon receptor	Homo sapiens	123-126
22022789-1	2012	The transgenic tobacco plant XD4V-26 carrying the recombinant mouse aryl hydrocarbon receptor XD4V-mediated beta-glucuronidase (GUS) reporter gene expression system was used for assay of dioxins and dioxin-like compounds consisting of polychlorinated dibenzeno-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls (Co-PCBs) in actually contaminated soils.	Dioxins	187-194	aryl-hydrocarbon receptor	Mus musculus	68-93
22022789-1	2012	The transgenic tobacco plant XD4V-26 carrying the recombinant mouse aryl hydrocarbon receptor XD4V-mediated beta-glucuronidase (GUS) reporter gene expression system was used for assay of dioxins and dioxin-like compounds consisting of polychlorinated dibenzeno-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls (Co-PCBs) in actually contaminated soils.	Dioxins	187-193	aryl-hydrocarbon receptor	Mus musculus	68-93
22022789-4	2012	When the tobacco plants were cultivated for up to 5 weeks on actually contaminated soils with dioxins and dioxin-like compounds collected from the periphery of an incinerator used for disposal of residential and industrial wastes, GUS activity in the leaves was dose-dependently increased.	Dioxins	94-101	glucuronidase, beta	Mus musculus	231-234
22022789-4	2012	When the tobacco plants were cultivated for up to 5 weeks on actually contaminated soils with dioxins and dioxin-like compounds collected from the periphery of an incinerator used for disposal of residential and industrial wastes, GUS activity in the leaves was dose-dependently increased.	Dioxins	94-100	glucuronidase, beta	Mus musculus	231-234
22022789-6	2012	There was a positive correlation between GUS activity and TEQ value of dioxins and dioxin-like compounds in the plants.	Dioxins	71-78	glucuronidase, beta	Mus musculus	41-44
22022789-6	2012	There was a positive correlation between GUS activity and TEQ value of dioxins and dioxin-like compounds in the plants.	Dioxins	71-77	glucuronidase, beta	Mus musculus	41-44
22509599-4	2012	The Dioxin concentrations in outflow water of bamboo, straw, reed, and bagasse pulping processes (chlorination alkaline extraction hypochlorite, CEH) are 41.8 pg x L(-1), 72.7 pg x L(-1), 7.46 pg x L(-1), and 19.7 pg x L(-1) respectively, which are all around the national waste water discharge standard (30 pg x L(-1)).	Dioxins	4-10	epoxide hydrolase 2	Homo sapiens	145-148
21753779-2	2012	Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery.	Dioxins	151-157	aryl hydrocarbon receptor	Homo sapiens	0-25
21753779-2	2012	Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery.	Dioxins	151-157	aryl hydrocarbon receptor	Homo sapiens	27-30
21753779-2	2012	Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery.	Dioxins	151-157	NFE2 like bZIP transcription factor 2	Homo sapiens	230-273
21753779-2	2012	Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery.	Dioxins	151-157	NFE2 like bZIP transcription factor 2	Homo sapiens	275-279
22428884-1	2012	The transgenic tobacco plant XD4V-26 carrying the recombinant mouse aryl hydrocarbon receptor XD4V-mediated beta-glucuronidase (GUS) reporter gene expression system was used for assay of dioxins and dioxin-like compounds consisting of polychlorodibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls (Co-PCBs) in actually contaminated soils.	Dioxins	187-193	aryl-hydrocarbon receptor	Mus musculus	68-93
22808131-6	2012	It included the repressor of the aryl hydrocarbon receptor (Ahrr), the chemokines Ccl5 and Cxcl4 previously shown to be regulated by dioxin in testis, Pgds2/Hpgds and 3 others uncharacterized.	Dioxins	133-139	aryl hydrocarbon receptor	Rattus norvegicus	33-58
22666488-0	2012	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.	Dioxins	25-31	insulin like growth factor 1	Homo sapiens	61-66
22615911-1	2012	Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	129-154
22615911-1	2012	Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	156-159
22615911-1	2012	Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl-hydrocarbon receptor	Mus musculus	129-154
22615911-1	2012	Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl-hydrocarbon receptor	Mus musculus	156-159
22615911-11	2012	Furthermore, other dioxin-like PCBs demonstrated similar effects on PEPCK expression in parallel with their ability to activate AhR.	Dioxins	19-25	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	68-73
22615911-11	2012	Furthermore, other dioxin-like PCBs demonstrated similar effects on PEPCK expression in parallel with their ability to activate AhR.	Dioxins	19-25	aryl-hydrocarbon receptor	Mus musculus	128-131
22615911-12	2012	It therefore appears that AhR activation mediates the suppression of PEPCK expression by dioxin-like PCBs, suggesting a role for these pollutants as disruptors of energy metabolism.	Dioxins	89-95	aryl-hydrocarbon receptor	Mus musculus	26-29
22615911-12	2012	It therefore appears that AhR activation mediates the suppression of PEPCK expression by dioxin-like PCBs, suggesting a role for these pollutants as disruptors of energy metabolism.	Dioxins	89-95	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	69-74
22235307-3	2012	Our data indicates that AHR and ARNT act independently from each other at non-dioxin response element sites.	Dioxins	78-84	aryl hydrocarbon receptor	Homo sapiens	24-27
22235307-3	2012	Our data indicates that AHR and ARNT act independently from each other at non-dioxin response element sites.	Dioxins	78-84	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	32-36
22235307-5	2012	Knockdown of AHR with siRNA abrogates dioxin-inducible repression of estrogen-dependent gene transcription.	Dioxins	38-44	aryl hydrocarbon receptor	Homo sapiens	13-16
22235307-11	2012	We have obtained experimental evidence demonstrating a dioxin-dependent repressor function for AHR and a dioxin-independent co-activator/co-repressor function for ARNT in estrogen signalling.	Dioxins	55-61	aryl hydrocarbon receptor	Homo sapiens	95-98
22235307-11	2012	We have obtained experimental evidence demonstrating a dioxin-dependent repressor function for AHR and a dioxin-independent co-activator/co-repressor function for ARNT in estrogen signalling.	Dioxins	105-111	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	163-167
22428884-4	2012	When the tobacco plants were cultivated for up to 5 weeks on actually contaminated soils with dioxins and dioxin-like compounds collected from the periphery of an incinerator used for disposal of life and industrial wastes, GUS activity in the leaves was dose-dependently increased.	Dioxins	94-101	glucuronidase, beta	Mus musculus	224-227
22428884-4	2012	When the tobacco plants were cultivated for up to 5 weeks on actually contaminated soils with dioxins and dioxin-like compounds collected from the periphery of an incinerator used for disposal of life and industrial wastes, GUS activity in the leaves was dose-dependently increased.	Dioxins	94-100	glucuronidase, beta	Mus musculus	224-227
22428884-6	2012	There was a positive correlation between GUS activity and TEQ value of dioxins and dioxin-like compounds in the plants.	Dioxins	71-78	glucuronidase, beta	Mus musculus	41-44
22428884-6	2012	There was a positive correlation between GUS activity and TEQ value of dioxins and dioxin-like compounds in the plants.	Dioxins	71-77	glucuronidase, beta	Mus musculus	41-44
22615911-0	2012	PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor.	Dioxins	18-24	pyruvate carboxylase	Mus musculus	0-3
22615911-0	2012	PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor.	Dioxins	18-24	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	65-70
22615911-0	2012	PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor.	Dioxins	18-24	aryl-hydrocarbon receptor	Mus musculus	90-115
22119029-6	2012	RESULTS: Three novel findings are elucidated: first, that up-regulation of CYP19 expression is associated with exposure to PCB groupings containing dioxin-like, potentially anti-estrogenic, immunotoxic congeners, including PCB IUPAC #74, #105, #118, #138, #156, #157, #158, #167, and #170 from this cohort.	Dioxins	148-154	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	75-80
22808131-6	2012	It included the repressor of the aryl hydrocarbon receptor (Ahrr), the chemokines Ccl5 and Cxcl4 previously shown to be regulated by dioxin in testis, Pgds2/Hpgds and 3 others uncharacterized.	Dioxins	133-139	C-C motif chemokine ligand 5	Rattus norvegicus	82-86
22808131-6	2012	It included the repressor of the aryl hydrocarbon receptor (Ahrr), the chemokines Ccl5 and Cxcl4 previously shown to be regulated by dioxin in testis, Pgds2/Hpgds and 3 others uncharacterized.	Dioxins	133-139	platelet factor 4	Rattus norvegicus	91-96
21775728-0	2011	Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness.	Dioxins	87-93	aryl-hydrocarbon receptor	Mus musculus	17-28
22036556-1	2011	The aryl hydrocarbon receptor (AhR) is responsible for the toxic effects of environmental pollutants such as dioxin, but little is known about its normal physiological functions.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	4-29
22036556-1	2011	The aryl hydrocarbon receptor (AhR) is responsible for the toxic effects of environmental pollutants such as dioxin, but little is known about its normal physiological functions.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	31-34
21976023-1	2011	Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular processes such as embryogenesis, transformation, tumorigenesis and inflammation.	Dioxins	137-143	aryl hydrocarbon receptor	Homo sapiens	18-43
21976023-1	2011	Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular processes such as embryogenesis, transformation, tumorigenesis and inflammation.	Dioxins	137-143	aryl hydrocarbon receptor	Homo sapiens	45-48
21767471-7	2011	The factorial design and PLS regression analyses of the effect of the PBDE-MIX indicated that BDE47 contributed the most to the observed CYP1A response, suggesting that this congener should be incorporated in the toxic equivalent (TEQ) concept in future risk assessment of dioxin-like chemicals.	Dioxins	273-279	cytochrome P450, family 1, subfamily A	Salmo salar	137-142
21858706-3	2011	PCB congeners pattern of marine organism were characterized by 5-6 CB chlorinated compounds, and the world health organization total dioxin equivalents of PCBs in organism ranged from 1.45 to 88.26 pg/g lipid.	Dioxins	133-139	pyruvate carboxylase	Homo sapiens	0-3
21777936-4	2011	Dioxin-like (DL-)PCB concentrations (1.7+-0.7 ng g(-1) fat, median 1.5 ng g(-1) fat, range 0.3-4.2 ng g(-1) fat) and the NDL-PCB to DL-PCB ratio (4.3) were similar to what is reported in EU for cow-based dairy products.	Dioxins	0-6	pyruvate carboxylase	Bos taurus	17-20
21168493-3	2011	Dioxins are unique compared to most chemicals that we are exposed to in the environment because they activate a high affinity receptor, aryl hydrocarbon receptor (AhR), that was identified more than three decades ago.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	136-161
21168493-3	2011	Dioxins are unique compared to most chemicals that we are exposed to in the environment because they activate a high affinity receptor, aryl hydrocarbon receptor (AhR), that was identified more than three decades ago.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	163-166
21168493-8	2011	Misregulation of AhR downstream pathways, such as conversion of arachidonic acid to prostanoids via cyclooxygenase-2, and altered Wnt/beta-catenin signaling downregulating Sox9, and signaling by receptors for inflammatory cytokines have been implicated in tissue-specific endpoints of dioxin toxicity.	Dioxins	285-291	aryl-hydrocarbon receptor	Mus musculus	17-20
21397018-1	2011	The arylhydrocarbon receptor (AhR) is a ligand-dependent transcription factor mediating the adverse effects of dioxins.	Dioxins	111-118	aryl hydrocarbon receptor	Homo sapiens	4-28
21397018-1	2011	The arylhydrocarbon receptor (AhR) is a ligand-dependent transcription factor mediating the adverse effects of dioxins.	Dioxins	111-118	aryl hydrocarbon receptor	Homo sapiens	30-33
21397018-3	2011	Recent studies showed that modulation of estrogen/androgen signaling by dioxins is exerted in part through direct association of AhR with estrogen (ER) or androgen (AR) receptors.	Dioxins	72-79	aryl hydrocarbon receptor	Homo sapiens	129-132
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	264-267
21775728-2	2011	The chemically activated luciferase expression (CALUX) system is an AhR-responsive recombinant luciferase reporter gene-based cell bioassay that has been used in combination with chemical extraction and cleanup methods for the relatively rapid and inexpensive detection and relative quantitation of dioxin and dioxin-like chemicals in a wide variety of sample matrices.	Dioxins	299-305	aryl-hydrocarbon receptor	Mus musculus	68-71
21775728-2	2011	The chemically activated luciferase expression (CALUX) system is an AhR-responsive recombinant luciferase reporter gene-based cell bioassay that has been used in combination with chemical extraction and cleanup methods for the relatively rapid and inexpensive detection and relative quantitation of dioxin and dioxin-like chemicals in a wide variety of sample matrices.	Dioxins	310-316	aryl-hydrocarbon receptor	Mus musculus	68-71
21726892-4	2011	The PCB baseline concentration (sum of seven PCB indicators (Sigma(7)PCB(ind))) determined on tree barks from a remote area in the Vosges mountains is 4 ng g(-1) and corresponds to 0.36 x 10(-3)ng toxic equivalent (TEQ) g(-1) for the dioxin-like PCBs (DL-PCBs).	Dioxins	234-240	pyruvate carboxylase	Homo sapiens	4-7
21726892-8	2011	However, very close to this incinerator lowest TEQ dioxin-like PCB (TEQ(DL-PCB)) values of 0.006 ng TEQ g(-1) have been found.	Dioxins	51-57	pyruvate carboxylase	Homo sapiens	63-66
21689841-2	2011	The toxicity of PAHs and dioxins are exclusively mediated through Aryl hydrocarbon Receptor (AhR).	Dioxins	25-32	aryl hydrocarbon receptor	Homo sapiens	66-91
21689841-2	2011	The toxicity of PAHs and dioxins are exclusively mediated through Aryl hydrocarbon Receptor (AhR).	Dioxins	25-32	aryl hydrocarbon receptor	Homo sapiens	93-96
21613234-1	2011	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.	Dioxins	199-206	aryl hydrocarbon receptor	Homo sapiens	4-29
21613234-1	2011	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.	Dioxins	199-206	aryl hydrocarbon receptor	Homo sapiens	31-34
21613234-2	2011	We hypothesized that polymorphisms of AHR may result in significant differences in sensitivity to toxic effects of PAHs or dioxins and contribute to susceptibility to male infertility.	Dioxins	123-130	aryl hydrocarbon receptor	Homo sapiens	38-41
22004731-3	2011	The sums of the concentrations of 56 non-dioxin-like PCB congeners that were measured in the subjects" blood and breast milk were 16-326 (mean: 107, median: 100) and 12-252 (mean: 73, median: 67) ng g(-1) lipid, respectively.	Dioxins	41-47	pyruvate carboxylase	Homo sapiens	53-56
22014662-0	2011	The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure - effects in reproductive organs.	Dioxins	68-74	aryl-hydrocarbon receptor	Mus musculus	39-45
22014662-1	2011	The dioxin/aryl hydrocarbon receptor (AhR) mediates most toxic effects of dioxins.	Dioxins	74-81	aryl-hydrocarbon receptor	Mus musculus	38-41
22014662-6	2011	Male and female reproductive tissues of CA-AhR mice were characterized for some of the effects commonly seen after dioxin exposure.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	40-46
22014662-11	2011	The results of the present study are in accordance with previous studies on dioxin-exposed rodents in that an activated AhR (here CA-AhR) leads to antiestrogenic effects in the presence of estrogen, but to estrogenic effects in the absence of estrogen.	Dioxins	76-82	aryl-hydrocarbon receptor	Mus musculus	120-123
22014662-11	2011	The results of the present study are in accordance with previous studies on dioxin-exposed rodents in that an activated AhR (here CA-AhR) leads to antiestrogenic effects in the presence of estrogen, but to estrogenic effects in the absence of estrogen.	Dioxins	76-82	aryl-hydrocarbon receptor	Mus musculus	130-136
21890736-8	2011	Furthermore, ChIP-chip analysis revealed AhR enrichment (up to 5.7-fold), and computational analysis identified 16 putative functional dioxin response elements (DREs) within Scd1 genomic loci.	Dioxins	135-141	stearoyl-Coenzyme A desaturase 1	Mus musculus	174-178
21787760-8	2011	Although, there have been very few studies that focus on the regulation of this important gene by physiological or exogenous factors, we recently found that the SOS1 gene was induced by the environmental toxin, dioxin, and that this effect was mediated by the aryl hydrocarbon receptor (AhR).	Dioxins	211-217	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	161-165
21787760-8	2011	Although, there have been very few studies that focus on the regulation of this important gene by physiological or exogenous factors, we recently found that the SOS1 gene was induced by the environmental toxin, dioxin, and that this effect was mediated by the aryl hydrocarbon receptor (AhR).	Dioxins	211-217	aryl hydrocarbon receptor	Homo sapiens	260-285
21787760-8	2011	Although, there have been very few studies that focus on the regulation of this important gene by physiological or exogenous factors, we recently found that the SOS1 gene was induced by the environmental toxin, dioxin, and that this effect was mediated by the aryl hydrocarbon receptor (AhR).	Dioxins	211-217	aryl hydrocarbon receptor	Homo sapiens	287-290
22052373-3	2011	The biological effects of dioxins are mediated via the aryl hydrocarbon receptor (AhR).	Dioxins	26-33	aryl hydrocarbon receptor	Homo sapiens	55-80
22052373-3	2011	The biological effects of dioxins are mediated via the aryl hydrocarbon receptor (AhR).	Dioxins	26-33	aryl hydrocarbon receptor	Homo sapiens	82-85
21684673-1	2011	The aryl hydrocarbon receptor (AHR) is an evolutionarily conserved ligand activated transcription factor best known for its role in mediating toxic responses to dioxin-like environmental contaminants.	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	4-29
21684673-1	2011	The aryl hydrocarbon receptor (AHR) is an evolutionarily conserved ligand activated transcription factor best known for its role in mediating toxic responses to dioxin-like environmental contaminants.	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	31-34
21470881-4	2011	On the same basis the dioxin-like PCB concentration in target milk decreased by 80% over the study period (from 0.95pg to 0.19pg TEQ/g fat).	Dioxins	22-28	pyruvate carboxylase	Bos taurus	34-37
21979385-1	2011	We have studied the effects of dioxin-like 3,3",4,4"-tetrachlorobiphenyl (PCB-77) on developmental effects related to angiogenesis and osteogenesis during early life-stages of salmon.	Dioxins	31-37	pyruvate carboxylase	Homo sapiens	74-77
21871440-0	2011	Human aryl-hydrocarbon receptor and its interaction with dioxin and physiological ligands investigated by molecular modelling and docking simulations.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	6-31
21871440-1	2011	Molecular structure of the ligand binding domain of hAhR has been modelled by homology modelling techniques and used for docking simulations with dioxin and nine more xenobiotics and endogenous ligands.	Dioxins	146-152	aryl hydrocarbon receptor	Homo sapiens	52-56
21705052-6	2011	In conclusion, it was found that the pituitary-ovarian axis in pigs is sensitive to TCDD, and the dioxin exhibited a profound ability to disrupt the ovarian actions of prolactin.	Dioxins	98-104	prolactin	Sus scrofa	168-177
21640702-1	2011	The aryl hydrocarbon receptor (AhR) has been best known for its role in mediating the toxicity of dioxin.	Dioxins	98-104	aryl hydrocarbon receptor	Homo sapiens	4-29
21640702-1	2011	The aryl hydrocarbon receptor (AhR) has been best known for its role in mediating the toxicity of dioxin.	Dioxins	98-104	aryl hydrocarbon receptor	Homo sapiens	31-34
21602191-2	2011	Using a model of contact-inhibited liver progenitor cells, we examined the interactions of Wnt/beta-catenin signaling with the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, which mediates the toxicity of dioxin-like compounds, including their effects on development and hepatocarcinogenesis.	Dioxins	232-238	aryl hydrocarbon receptor	Homo sapiens	127-152
21602191-2	2011	Using a model of contact-inhibited liver progenitor cells, we examined the interactions of Wnt/beta-catenin signaling with the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, which mediates the toxicity of dioxin-like compounds, including their effects on development and hepatocarcinogenesis.	Dioxins	232-238	aryl hydrocarbon receptor	Homo sapiens	154-157
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	242-253
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	255-258
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	264-267
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	242-253
21775728-1	2011	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	255-258
21493753-1	2011	The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities.	Dioxins	87-93	aryl hydrocarbon receptor	Homo sapiens	32-57
21762485-2	2011	Integration of TCDD-induced genome-wide AhR enrichment, differential gene expression and computational dioxin response element (DRE) analyses further elucidate the hepatic AhR regulatory network.	Dioxins	103-109	aryl-hydrocarbon receptor	Mus musculus	172-175
21600206-2	2011	Aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that mediates the toxicity of dioxins, controls T-cell responses.	Dioxins	103-110	aryl-hydrocarbon receptor	Mus musculus	0-25
21600206-2	2011	Aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that mediates the toxicity of dioxins, controls T-cell responses.	Dioxins	103-110	aryl-hydrocarbon receptor	Mus musculus	27-30
21534955-2	2011	TCDD is a ligand of the aryl hydrocarbon receptor (AhR), which is a key signaling molecule to fully understand the toxic and carcinogenic properties of dioxin.	Dioxins	152-158	aryl-hydrocarbon receptor	Mus musculus	24-49
21534955-2	2011	TCDD is a ligand of the aryl hydrocarbon receptor (AhR), which is a key signaling molecule to fully understand the toxic and carcinogenic properties of dioxin.	Dioxins	152-158	aryl-hydrocarbon receptor	Mus musculus	51-54
21493753-1	2011	The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities.	Dioxins	87-93	aryl hydrocarbon receptor	Homo sapiens	59-62
25213920-1	2011	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicological effects by binding to agonists such as dioxins.	Dioxins	146-153	aryl hydrocarbon receptor	Homo sapiens	4-29
21498875-1	2011	The expression of cytochrome P450 (CYP) 1a1 and other drug-metabolizing enzymes is controlled by the aryl hydrocarbon receptor (AhR), which is activated by dioxin-type inducers leading to transcriptional induction of target genes.	Dioxins	156-162	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	18-43
21498875-1	2011	The expression of cytochrome P450 (CYP) 1a1 and other drug-metabolizing enzymes is controlled by the aryl hydrocarbon receptor (AhR), which is activated by dioxin-type inducers leading to transcriptional induction of target genes.	Dioxins	156-162	aryl-hydrocarbon receptor	Mus musculus	101-126
21498875-1	2011	The expression of cytochrome P450 (CYP) 1a1 and other drug-metabolizing enzymes is controlled by the aryl hydrocarbon receptor (AhR), which is activated by dioxin-type inducers leading to transcriptional induction of target genes.	Dioxins	156-162	aryl-hydrocarbon receptor	Mus musculus	128-131
21616713-8	2011	Among the dioxin-like PCBs, PCB 118, PCB 156 and PCB 167 were detectable in 74-98% of all samples.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	22-25
21616713-8	2011	Among the dioxin-like PCBs, PCB 118, PCB 156 and PCB 167 were detectable in 74-98% of all samples.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	28-31
21616713-8	2011	Among the dioxin-like PCBs, PCB 118, PCB 156 and PCB 167 were detectable in 74-98% of all samples.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	28-31
25213920-1	2011	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicological effects by binding to agonists such as dioxins.	Dioxins	146-153	aryl hydrocarbon receptor	Homo sapiens	31-34
21441140-9	2011	CONCLUSION: The results suggest that CXCR2 mediates the atherogenic activity of environmental pollutants, such as dioxins, and contributes to the development of atherosclerosis through the induction of a vascular inflammatory response by activating the AhR-signaling pathway.	Dioxins	114-121	chemokine (C-X-C motif) receptor 2	Mus musculus	37-42
21354474-8	2011	The number of putative dioxin response elements found in each CYP1 gene promoter roughly reflected the induction levels of the genes.	Dioxins	23-29	peptidylprolyl isomerase Aa (cyclophilin A)	Danio rerio	62-66
20878756-2	2011	Dioxin-like compounds can activate the aryl hydrocarbon receptor (AhR) and alter macrophage function as well as T-cell polarization.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	39-64
21576463-2	2011	Development of Th17 can be enhanced by the activation of aryl hydrocarbon receptor (AHR) whose ligands include the environmental pollutant dioxin, potentially linking environmental factors to the increased prevalence of autoimmune disease.	Dioxins	139-145	aryl-hydrocarbon receptor	Mus musculus	57-82
21576463-2	2011	Development of Th17 can be enhanced by the activation of aryl hydrocarbon receptor (AHR) whose ligands include the environmental pollutant dioxin, potentially linking environmental factors to the increased prevalence of autoimmune disease.	Dioxins	139-145	aryl-hydrocarbon receptor	Mus musculus	84-87
20878756-2	2011	Dioxin-like compounds can activate the aryl hydrocarbon receptor (AhR) and alter macrophage function as well as T-cell polarization.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	66-69
21292640-6	2011	In contrast, the non-dioxin-like PCB153 recruits AHR to the Cyp1a1 enhancer causing a displacement of enhancer-associated histone H3 but does not cause the other observed histone mark changes nor does it induce transcription.	Dioxins	21-27	aryl hydrocarbon receptor	Homo sapiens	49-52
21292640-6	2011	In contrast, the non-dioxin-like PCB153 recruits AHR to the Cyp1a1 enhancer causing a displacement of enhancer-associated histone H3 but does not cause the other observed histone mark changes nor does it induce transcription.	Dioxins	21-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	60-66
21296121-0	2011	Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects.	Dioxins	0-6	CD34 molecule	Homo sapiens	25-29
21357386-1	2011	The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs.	Dioxins	173-179	aryl hydrocarbon receptor	Homo sapiens	111-136
21357386-1	2011	The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs.	Dioxins	173-179	aryl hydrocarbon receptor	Homo sapiens	138-141
21296121-7	2011	The transcriptional profile induced by TCDD treatment on human CD34+ cells strikingly reproduces the clinical and biological effects observed in individuals exposed to dioxin and in biological experimental systems.	Dioxins	168-174	CD34 molecule	Homo sapiens	63-67
21525997-0	2011	In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	8-14	interleukin 22	Homo sapiens	22-36
21525997-0	2011	In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	8-14	CD4 molecule	Homo sapiens	57-60
21525997-0	2011	In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	76-101
21525997-0	2011	In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner.	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	103-106
21525997-1	2011	BACKGROUND: The transcription factor aryl hydrocarbon receptor (AhR) mediates the effects of a group of chemicals known as dioxins, ubiquitously present in our environment.	Dioxins	123-130	aryl hydrocarbon receptor	Homo sapiens	37-62
21525997-1	2011	BACKGROUND: The transcription factor aryl hydrocarbon receptor (AhR) mediates the effects of a group of chemicals known as dioxins, ubiquitously present in our environment.	Dioxins	123-130	aryl hydrocarbon receptor	Homo sapiens	64-67
21356177-11	2011	Overall, our results show that dietary exposure to sublethal concentrations of brominated dioxins may impair reproductive physiology in fish and induce AHR-regulated genes.	Dioxins	90-97	aryl hydrocarbon receptor 1a	Danio rerio	152-155
21370876-1	2011	The aryl hydrocarbon receptor (AhR) mediates responses elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin by binding to dioxin response elements (DRE) containing the core consensus sequence 5"-GCGTG-3".	Dioxins	96-102	aryl hydrocarbon receptor	Homo sapiens	4-29
21370876-1	2011	The aryl hydrocarbon receptor (AhR) mediates responses elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin by binding to dioxin response elements (DRE) containing the core consensus sequence 5"-GCGTG-3".	Dioxins	96-102	aryl hydrocarbon receptor	Homo sapiens	31-34
21258071-3	2011	Cytochrome P450 (CYP) 1A1 proteins can metabolize some dioxins and PCBs by hydroxylation, but the activities of human and rat CYP1A1 proteins are very different.	Dioxins	55-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-25
21410761-5	2011	Aryl hydrocarbon receptor (AhR) protein expression, the receptor for dioxin, was detected in SZ95 sebocytes.	Dioxins	69-75	aryl hydrocarbon receptor	Homo sapiens	0-25
21410761-5	2011	Aryl hydrocarbon receptor (AhR) protein expression, the receptor for dioxin, was detected in SZ95 sebocytes.	Dioxins	69-75	aryl hydrocarbon receptor	Homo sapiens	27-30
21258071-3	2011	Cytochrome P450 (CYP) 1A1 proteins can metabolize some dioxins and PCBs by hydroxylation, but the activities of human and rat CYP1A1 proteins are very different.	Dioxins	55-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	126-132
21205634-0	2011	Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	49-60
21205634-3	2011	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the prototypical AHR ligand and dioxin congener and a model for many environmentally relevant organochlorinated compounds.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	63-66
21205634-4	2011	Research over the course of the last 30 years has made it evident that AHR activation in response to TCDD and other xenobiotic agonists directly affects multiple metabolic pathways, leading to the identification of many AHR-directed effects of dioxin involved in regulation of growth factor signaling, cell cycle proliferation, differentiation, arrest, and apoptosis.	Dioxins	244-250	aryl hydrocarbon receptor	Homo sapiens	71-74
21342125-6	2011	Several exogenous AhR ligands, such as PAHs, polychlorinated biphenyls and halogenated dioxins, can be found in the constituents of numerous commercial products, including insulators and flame retardants, or as products of combustion processes, including chimney soot, charbroiled foods and cigarette smoke, or as the product of waste incineration.	Dioxins	87-94	aryl hydrocarbon receptor	Homo sapiens	18-21
21479225-0	2011	RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.	Dioxins	57-63	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
21205634-4	2011	Research over the course of the last 30 years has made it evident that AHR activation in response to TCDD and other xenobiotic agonists directly affects multiple metabolic pathways, leading to the identification of many AHR-directed effects of dioxin involved in regulation of growth factor signaling, cell cycle proliferation, differentiation, arrest, and apoptosis.	Dioxins	244-250	aryl hydrocarbon receptor	Homo sapiens	220-223
20835891-0	2011	PCDD/F and dioxin-like PCB profiles in soils amended with sewage sludge, compost, farmyard manure, and mineral fertilizer since 1962.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
21237254-0	2011	Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins.	Dioxins	101-108	epidermal growth factor receptor	Homo sapiens	29-33
21237254-0	2011	Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins.	Dioxins	101-108	keratin 17	Homo sapiens	35-39
21237254-0	2011	Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins.	Dioxins	101-108	transglutaminase 1	Homo sapiens	44-47
21237254-3	2011	The aim of the present study was to investigate the role of EGFR, MAPK, CK17, and TGk in the pathogenesis of chloracne related to dioxin exposures.	Dioxins	130-136	epidermal growth factor receptor	Homo sapiens	60-64
21237254-3	2011	The aim of the present study was to investigate the role of EGFR, MAPK, CK17, and TGk in the pathogenesis of chloracne related to dioxin exposures.	Dioxins	130-136	keratin 17	Homo sapiens	72-76
21237254-3	2011	The aim of the present study was to investigate the role of EGFR, MAPK, CK17, and TGk in the pathogenesis of chloracne related to dioxin exposures.	Dioxins	130-136	transglutaminase 1	Homo sapiens	82-85
21237254-12	2011	CONCLUSIONS: The results demonstrate that in the human skin the activation of mitogen-activated protein kinase pathway and up-regulation of CK17 and TGK may play roles in the pathogenesis of chloracne related to dioxin exposures.	Dioxins	212-218	keratin 17	Homo sapiens	140-144
21237254-12	2011	CONCLUSIONS: The results demonstrate that in the human skin the activation of mitogen-activated protein kinase pathway and up-regulation of CK17 and TGK may play roles in the pathogenesis of chloracne related to dioxin exposures.	Dioxins	212-218	transglutaminase 1	Homo sapiens	149-152
21182907-1	2011	Activation of the aryl hydrocarbon receptor (AhR) by the highly toxic, prototypical ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or other dioxin-like compounds compromises ovarian function by altering follicle maturation and steroid synthesis.	Dioxins	121-127	aryl-hydrocarbon receptor	Mus musculus	18-43
21182907-1	2011	Activation of the aryl hydrocarbon receptor (AhR) by the highly toxic, prototypical ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or other dioxin-like compounds compromises ovarian function by altering follicle maturation and steroid synthesis.	Dioxins	121-127	aryl-hydrocarbon receptor	Mus musculus	45-48
21182907-2	2011	Although alteration of transcription after nuclear translocation and heterodimerization of AhR with its binding partner, aryl hydrocarbon nuclear transporter (ARNT), is often cited as a primary mechanism for mediating the toxic effects of dioxins, recent evidence indicates that crosstalk between AhR and several other signaling pathways also occurs.	Dioxins	239-246	aryl-hydrocarbon receptor	Mus musculus	91-94
21182907-2	2011	Although alteration of transcription after nuclear translocation and heterodimerization of AhR with its binding partner, aryl hydrocarbon nuclear transporter (ARNT), is often cited as a primary mechanism for mediating the toxic effects of dioxins, recent evidence indicates that crosstalk between AhR and several other signaling pathways also occurs.	Dioxins	239-246	aryl hydrocarbon receptor nuclear translocator	Mus musculus	121-157
21182907-2	2011	Although alteration of transcription after nuclear translocation and heterodimerization of AhR with its binding partner, aryl hydrocarbon nuclear transporter (ARNT), is often cited as a primary mechanism for mediating the toxic effects of dioxins, recent evidence indicates that crosstalk between AhR and several other signaling pathways also occurs.	Dioxins	239-246	aryl hydrocarbon receptor nuclear translocator	Mus musculus	159-163
21182907-2	2011	Although alteration of transcription after nuclear translocation and heterodimerization of AhR with its binding partner, aryl hydrocarbon nuclear transporter (ARNT), is often cited as a primary mechanism for mediating the toxic effects of dioxins, recent evidence indicates that crosstalk between AhR and several other signaling pathways also occurs.	Dioxins	239-246	aryl-hydrocarbon receptor	Mus musculus	297-300
21205633-2	2011	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) protein.	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	54-79
21205633-2	2011	It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) protein.	Dioxins	8-14	aryl hydrocarbon receptor	Homo sapiens	81-84
21215274-1	2011	The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR).	Dioxins	4-10	aryl hydrocarbon receptor	Rattus norvegicus	193-218
21215274-1	2011	The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR).	Dioxins	4-10	aryl hydrocarbon receptor	Rattus norvegicus	220-223
21215274-4	2011	Despite this large deletion, H/W rats are not entirely refractory to the effects of TCDD; the variant AHR in these animals remains fully competent to up-regulate well-known dioxin-inducible genes.	Dioxins	173-179	aryl hydrocarbon receptor	Rattus norvegicus	102-105
21204517-1	2011	To evaluate the sensitivity and responses to dioxins and related compounds (DRCs) via aryl hydrocarbon receptor (AHR) in Baikal seals (Pusa sibirica), we constructed an in vitro reporter gene assay system.	Dioxins	45-52	aryl-hydrocarbon receptor	Mus musculus	113-116
21204517-6	2011	The TCDD-EC50 for BS AHR was as high as that for dioxin sensitive C57BL/6 mouse AHR.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	80-83
21068195-1	2011	CYP2S1 is a recently described dioxin-inducible cytochrome P450.	Dioxins	31-37	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	0-6
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	80-83
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	Dioxins	13-19	telomerase reverse transcriptase	Homo sapiens	106-111
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	198-201
20950586-3	2011	Large-scale studies have shown that the expression of Son of Sevenless 1 (SOS1), the main mediator of Ras activation, is one of the targets of dioxin in human cultured cells.	Dioxins	143-149	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	54-72
21087821-0	2011	Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance.	Dioxins	57-64	insulin	Homo sapiens	101-108
21087821-6	2011	After adjusting for confounding factors, we found that insulin resistance increased with serum dioxins (b = 0.13, P < 0.001) and blood mercury (b = 0.01, P < 0.001).	Dioxins	95-102	insulin	Homo sapiens	55-62
21087821-7	2011	Moreover, participants with higher serum dioxins or blood mercury were at a significantly increasing risk for insulin resistance (P(trend) < 0.001).	Dioxins	41-48	insulin	Homo sapiens	110-117
21087821-9	2011	We hypothesize that simultaneous exposure to dioxins and mercury heightens the risk of insulin resistance more than does individual exposure.	Dioxins	45-52	insulin	Homo sapiens	87-94
20950586-3	2011	Large-scale studies have shown that the expression of Son of Sevenless 1 (SOS1), the main mediator of Ras activation, is one of the targets of dioxin in human cultured cells.	Dioxins	143-149	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	74-78
20950586-7	2011	We also showed that dioxin treatment leads to an activated Ras-GTP state, to ERK activation and to accelerated cellular proliferation.	Dioxins	20-26	mitogen-activated protein kinase 1	Homo sapiens	77-80
20950586-9	2011	Our data indicate that dioxin-induced cellular proliferation is mediated, at least partially, by SOS1 induction.	Dioxins	23-29	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	97-101
20965207-6	2011	The extent of CYP1 induction by PCB126 and betaNF was positively correlated to the number of putative dioxin response elements 0-20 kb upstream of the start codons.	Dioxins	102-108	cytochrome P450 family 1 subfamily A member 1	Xenopus tropicalis	14-18
20709182-1	2011	The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological responses via the arylhydrocarbon receptor (AhR).	Dioxins	4-11	aryl hydrocarbon receptor	Homo sapiens	106-130
20709182-1	2011	The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological responses via the arylhydrocarbon receptor (AhR).	Dioxins	4-11	aryl hydrocarbon receptor	Homo sapiens	132-135
20709182-1	2011	The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological responses via the arylhydrocarbon receptor (AhR).	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	106-130
20709182-1	2011	The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological responses via the arylhydrocarbon receptor (AhR).	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	132-135
21828933-2	2011	In the case of dioxin-like compounds (DLCs), it has been hypothesized that single nucleotide polymorphisms (SNPs) in genes associated with aryl hydrocarbon receptor (AHR)-regulated pathways may result in greater susceptibility to DLC toxicity.	Dioxins	15-21	aryl hydrocarbon receptor	Homo sapiens	139-164
22296395-2	2011	The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments.	Dioxins	117-124	aryl hydrocarbon receptor	Homo sapiens	4-29
22296395-2	2011	The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments.	Dioxins	117-124	aryl hydrocarbon receptor	Homo sapiens	31-34
21512261-2	2011	It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP).	Dioxins	55-61	aryl hydrocarbon receptor	Homo sapiens	105-108
21512261-2	2011	It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP).	Dioxins	55-61	aryl hydrocarbon receptor interacting protein	Homo sapiens	148-171
21512261-2	2011	It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP).	Dioxins	55-61	aryl hydrocarbon receptor interacting protein	Homo sapiens	173-176
21828933-2	2011	In the case of dioxin-like compounds (DLCs), it has been hypothesized that single nucleotide polymorphisms (SNPs) in genes associated with aryl hydrocarbon receptor (AHR)-regulated pathways may result in greater susceptibility to DLC toxicity.	Dioxins	15-21	aryl hydrocarbon receptor	Homo sapiens	166-169
21187307-7	2011	Boys in the highest exposure quintile of the sum of dioxin and PCB concentrations and total TEQs had a significant decrease in mean BMI z scores of 0.67 for dioxins and TEQs and 1.04 for PCBs, compared with boys in the lowest exposure quintile.	Dioxins	157-164	pyruvate carboxylase	Homo sapiens	63-66
21797774-1	2011	Smoking appears to enhance the body"s clearance of dioxins and dioxin-like polychlorinated biphenyls (PCB) by inducing CYP1A2 activity based on studies with a limited number of participants.	Dioxins	51-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
21797774-1	2011	Smoking appears to enhance the body"s clearance of dioxins and dioxin-like polychlorinated biphenyls (PCB) by inducing CYP1A2 activity based on studies with a limited number of participants.	Dioxins	51-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
21866765-6	2011	Effluents reused for irrigation exhibited ER and AhR activities at 38.5 +/- 9.9 ng estradiol-equivalent/L (ng E2-EQ/L) and 113.3 +/- 27.7 ng dioxin-equivalent/L (ng TCDD-EQ/L), respectively.	Dioxins	141-147	aryl hydrocarbon receptor	Homo sapiens	49-52
22312956-4	2011	Based on recent epidemiological studies, this article aims the mechanism by which dioxins exert their effect on tumors induction, formation of insulin-resistance, fertility in men and women as well as children development.	Dioxins	82-89	insulin	Homo sapiens	143-150
22194803-0	2011	A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity.	Dioxins	80-86	aryl hydrocarbon receptor 2	Danio rerio	30-34
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-70
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	84-90
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	aryl hydrocarbon receptor	Homo sapiens	128-131
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	estrogen receptor 1	Homo sapiens	133-140
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	162-168
20846786-3	2010	Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1.	Dioxins	36-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	173-179
21183436-9	2010	It binds to dioxin, translocates to nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1.Dioxins are classified as known human carcinogens, but they also cause noncancerous effects like atherosclerosis, hypertension, and diabetes.	Dioxins	12-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	170-176
21183436-9	2010	It binds to dioxin, translocates to nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1.Dioxins are classified as known human carcinogens, but they also cause noncancerous effects like atherosclerosis, hypertension, and diabetes.	Dioxins	12-18	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	96-100
20973933-3	2010	We show here that exposure of normal human melanocytes to the most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), results in activation of the AHR signaling pathway and an AHR-dependent induction of tyrosinase activity, the key enzyme of the melanogenic pathway.	Dioxins	74-80	aryl hydrocarbon receptor	Homo sapiens	155-158
20973933-3	2010	We show here that exposure of normal human melanocytes to the most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), results in activation of the AHR signaling pathway and an AHR-dependent induction of tyrosinase activity, the key enzyme of the melanogenic pathway.	Dioxins	74-80	aryl hydrocarbon receptor	Homo sapiens	184-187
20973933-3	2010	We show here that exposure of normal human melanocytes to the most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), results in activation of the AHR signaling pathway and an AHR-dependent induction of tyrosinase activity, the key enzyme of the melanogenic pathway.	Dioxins	74-80	tyrosinase	Homo sapiens	211-221
20819910-0	2010	Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific.	Dioxins	102-109	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
20840854-0	2010	Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis.	Dioxins	4-10	tumor protein p53	Homo sapiens	58-61
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Dioxins	2-8	pyruvate carboxylase	Homo sapiens	14-17
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Dioxins	2-8	pyruvate carboxylase	Homo sapiens	19-29
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Dioxins	2-8	tumor protein p53	Homo sapiens	145-148
20935161-1	2010	The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system.	Dioxins	105-112	aryl-hydrocarbon receptor	Mus musculus	4-29
20935161-1	2010	The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system.	Dioxins	105-112	aryl-hydrocarbon receptor	Mus musculus	31-34
20935161-5	2010	In an effort to clarify the role of ARNT in AHR-mediated dioxin hepatotoxicity, we generated a conditional Arnt mouse model.	Dioxins	57-63	aryl-hydrocarbon receptor	Mus musculus	44-47
20935161-7	2010	Using a hepatocyte-specific Arnt deletion, we were able to demonstrate that hepatocyte ARNT is required for major aspects of AHR-mediated dioxin toxicity in the liver.	Dioxins	138-144	aryl hydrocarbon receptor nuclear translocator	Mus musculus	28-32
20935161-7	2010	Using a hepatocyte-specific Arnt deletion, we were able to demonstrate that hepatocyte ARNT is required for major aspects of AHR-mediated dioxin toxicity in the liver.	Dioxins	138-144	aryl hydrocarbon receptor nuclear translocator	Mus musculus	87-91
20935161-7	2010	Using a hepatocyte-specific Arnt deletion, we were able to demonstrate that hepatocyte ARNT is required for major aspects of AHR-mediated dioxin toxicity in the liver.	Dioxins	138-144	aryl-hydrocarbon receptor	Mus musculus	125-128
20829355-0	2010	The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.	Dioxins	72-78	aryl hydrocarbon receptor interacting protein	Homo sapiens	4-49
20829355-0	2010	The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.	Dioxins	72-78	aryl hydrocarbon receptor interacting protein	Homo sapiens	51-54
20829355-1	2010	The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	4-29
20829355-1	2010	The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	31-34
20829355-6	2010	(ii) Expression of the AIP protein is essential for dioxin-induced hepatotoxicity.	Dioxins	52-58	aryl hydrocarbon receptor interacting protein	Homo sapiens	23-26
21183436-9	2010	It binds to dioxin, translocates to nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1.Dioxins are classified as known human carcinogens, but they also cause noncancerous effects like atherosclerosis, hypertension, and diabetes.	Dioxins	177-184	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	96-100
20829355-8	2010	The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not.	Dioxins	77-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	4-10
20829355-8	2010	The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not.	Dioxins	77-83	aryl hydrocarbon receptor repressor	Homo sapiens	15-19
21183436-9	2010	It binds to dioxin, translocates to nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1.Dioxins are classified as known human carcinogens, but they also cause noncancerous effects like atherosclerosis, hypertension, and diabetes.	Dioxins	177-184	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	170-176
20829355-8	2010	The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not.	Dioxins	77-83	aryl hydrocarbon receptor interacting protein	Homo sapiens	34-37
21079739-0	2010	Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	107-132
20829355-9	2010	This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.	Dioxins	235-241	aryl hydrocarbon receptor interacting protein	Homo sapiens	32-35
20829355-9	2010	This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.	Dioxins	235-241	aryl hydrocarbon receptor	Homo sapiens	112-115
20829355-9	2010	This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.	Dioxins	235-241	aryl hydrocarbon receptor interacting protein	Homo sapiens	164-167
20829355-9	2010	This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.	Dioxins	235-241	aryl hydrocarbon receptor	Homo sapiens	179-182
21079739-0	2010	Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor.	Dioxins	56-62	aryl-hydrocarbon receptor	Mus musculus	107-132
21079739-1	2010	The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne.	Dioxins	86-93	aryl-hydrocarbon receptor	Mus musculus	4-29
21079739-1	2010	The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne.	Dioxins	86-93	aryl-hydrocarbon receptor	Mus musculus	31-34
21079739-2	2010	Elimination of Ahr in mice eliminates dioxin toxicity but also produces adverse effects, some seemingly unrelated to dioxin.	Dioxins	38-44	aryl-hydrocarbon receptor	Mus musculus	15-18
21079739-2	2010	Elimination of Ahr in mice eliminates dioxin toxicity but also produces adverse effects, some seemingly unrelated to dioxin.	Dioxins	117-123	aryl-hydrocarbon receptor	Mus musculus	15-18
21079739-3	2010	Thus the relationship between the toxic and dioxin-independent functions of Ahr is not clear, which hampers understanding and treatment of dioxin toxicity.	Dioxins	44-50	aryl-hydrocarbon receptor	Mus musculus	76-79
21079739-3	2010	Thus the relationship between the toxic and dioxin-independent functions of Ahr is not clear, which hampers understanding and treatment of dioxin toxicity.	Dioxins	139-145	aryl-hydrocarbon receptor	Mus musculus	76-79
21079739-4	2010	Here we develop a Drosophila model to show that dioxin actually increases the in vivo dioxin-independent activity of Ahr.	Dioxins	48-54	spineless	Drosophila melanogaster	117-120
21079739-4	2010	Here we develop a Drosophila model to show that dioxin actually increases the in vivo dioxin-independent activity of Ahr.	Dioxins	86-92	spineless	Drosophila melanogaster	117-120
21079739-6	2010	Thus the two apparently different functions of Ahr, dioxin-mediated and dioxin-independent, are in fact two different levels (hyperactivated and basal, respectively) of a single function.	Dioxins	52-58	aryl-hydrocarbon receptor	Mus musculus	47-50
21079739-6	2010	Thus the two apparently different functions of Ahr, dioxin-mediated and dioxin-independent, are in fact two different levels (hyperactivated and basal, respectively) of a single function.	Dioxins	72-78	aryl-hydrocarbon receptor	Mus musculus	47-50
20868221-2	2010	One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds.	Dioxins	197-204	aryl hydrocarbon receptor	Homo sapiens	56-81
20868221-2	2010	One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds.	Dioxins	197-204	aryl hydrocarbon receptor	Homo sapiens	83-86
19969354-3	2010	The goal of the present study was to evaluate the effects of a single, very low dose of PCB 126 (3,3",4,4",5-pentachlorobiphenyl), a coplanar, dioxin-like PCB congener and aryl hydrocarbon receptor (AhR) agonist, on redox status, metals homeostasis, antioxidant enzymes, and cellular morphology.	Dioxins	143-149	pyruvate carboxylase	Rattus norvegicus	88-91
19261331-10	2010	These modified reaction conditions allow the synthesis of large quantities of pure, non-dioxin-like PCB congeners and their sulfur-containing metabolites for environmental and toxicological studies by overcoming problems associated with classical PCB synthesis strategies.	Dioxins	88-94	pyruvate carboxylase	Homo sapiens	100-103
19261331-10	2010	These modified reaction conditions allow the synthesis of large quantities of pure, non-dioxin-like PCB congeners and their sulfur-containing metabolites for environmental and toxicological studies by overcoming problems associated with classical PCB synthesis strategies.	Dioxins	88-94	pyruvate carboxylase	Homo sapiens	247-250
20938504-0	2010	Screening of dioxin-like compounds in bio-composts and their materials: chemical analysis and fractionation-directed evaluation of AhR ligand activities using an in vitro bioassay.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	131-134
21383778-2	2010	UNLABELLED: Dioxin Toxic Equivalency Factor Evaluation Overview- Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	TEF transcription factor, PAR bZIP family member	Homo sapiens	19-43
21383778-2	2010	UNLABELLED: Dioxin Toxic Equivalency Factor Evaluation Overview- Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl hydrocarbon receptor	Rattus norvegicus	242-267
21383778-2	2010	UNLABELLED: Dioxin Toxic Equivalency Factor Evaluation Overview- Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl hydrocarbon receptor	Rattus norvegicus	269-272
21383778-3	2010	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds"(DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
21383778-7	2010	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
21383778-8	2010	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
20801906-1	2010	Exposure to dioxin and other aryl hydrocarbon receptor (AhR) ligands results in multiple, specific developmental cardiovascular phenotypes including pericardial edema and circulatory failure in small aquarium fish models.	Dioxins	12-18	aryl hydrocarbon receptor 1b	Oryzias latipes	56-59
19969354-3	2010	The goal of the present study was to evaluate the effects of a single, very low dose of PCB 126 (3,3",4,4",5-pentachlorobiphenyl), a coplanar, dioxin-like PCB congener and aryl hydrocarbon receptor (AhR) agonist, on redox status, metals homeostasis, antioxidant enzymes, and cellular morphology.	Dioxins	143-149	pyruvate carboxylase	Rattus norvegicus	155-158
20959002-11	2010	In addition, the time independent gene expression signature of the AhR ligands may assist in identifying other agents with the potential to elicit dioxin-like hepatotoxic responses.	Dioxins	147-153	aryl hydrocarbon receptor	Rattus norvegicus	67-70
20631054-0	2010	Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes.	Dioxins	64-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
20924108-5	2010	Additionally, miR-191 was found to be upregulated by a dioxin, a known liver carcinogen, and was found to be a regulator of a variety of cancer-related pathways.	Dioxins	55-61	microRNA 191	Homo sapiens	14-21
20631054-0	2010	Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes.	Dioxins	64-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	98-104
20631054-1	2010	The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions.	Dioxins	110-116	aryl hydrocarbon receptor	Homo sapiens	4-29
20631054-1	2010	The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions.	Dioxins	110-116	aryl hydrocarbon receptor	Homo sapiens	31-34
20631054-1	2010	The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
20631054-1	2010	The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions.	Dioxins	110-116	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	69-75
20631054-2	2010	CYP1A1 and CYPIB1 were both inducible by dioxin in human MCF-7 cells.	Dioxins	41-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
20631054-2	2010	CYP1A1 and CYPIB1 were both inducible by dioxin in human MCF-7 cells.	Dioxins	41-47	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	11-17
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	34-37
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	E1A binding protein p300	Homo sapiens	75-79
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	E1A binding protein p300	Homo sapiens	84-88
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	lysine acetyltransferase 2B	Homo sapiens	162-166
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	175-181
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	TATA-box binding protein	Homo sapiens	275-295
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	TATA-box binding protein	Homo sapiens	297-300
20631054-6	2010	Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin.	Dioxins	30-36	E1A binding protein p300	Homo sapiens	8-12
20631054-6	2010	Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin.	Dioxins	30-36	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	98-104
20631054-6	2010	Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin.	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	203-206
20957046-1	2010	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals.	Dioxins	145-152	aryl hydrocarbon receptor 1a	Danio rerio	16-41
20957046-1	2010	BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals.	Dioxins	145-152	aryl hydrocarbon receptor 1a	Danio rerio	43-46
20655778-0	2010	Specific interactions between aryl hydrocarbon receptor and dioxin congeners: ab initio fragment molecular orbital calculations.	Dioxins	60-66	aryl hydrocarbon receptor	Rattus norvegicus	30-55
20631054-6	2010	Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin.	Dioxins	284-290	E1A binding protein p300	Homo sapiens	8-12
20541864-4	2010	The PCDD/F, dioxin-like PCB, PCB and PAH concentrations in this input waste mix were more than hundred times higher than in the usual waste feed of the incinerator (30% RFD and 70% WWT sludge).	Dioxins	12-18	pyruvate carboxylase	Homo sapiens	24-27
20720200-1	2010	The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after binding dioxin.	Dioxins	92-98	aryl-hydrocarbon receptor	Mus musculus	4-29
20720200-1	2010	The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after binding dioxin.	Dioxins	92-98	aryl-hydrocarbon receptor	Mus musculus	31-34
20805476-0	2010	In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1.	Dioxins	21-27	cyclin-dependent kinase inhibitor 1B	Mus musculus	81-88
20805476-6	2010	These results show that environmental pollutants may affect neocortical histogenesis through alterations of functions of specific gene(s)/protein(s) (in our case, dioxins), exerting adverse effects by altering functions of p27(Kip1).	Dioxins	163-170	cyclin-dependent kinase inhibitor 1B	Mus musculus	223-226
20696431-9	2010	All toxic, dioxin-like PCBs, with the exception of PCB 118 that overlaps with PCB 106, were resolved by the apolar/ionic liquid series while on the apolar/polar column series three toxic PCBs overlapped (105+127, 81+148 and 118+106).	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
20652238-1	2010	The angular dioxygenase, cytochrome P450, lignin peroxidase, and dehalogenase are known as dioxin-metabolizing enzymes.	Dioxins	91-97	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-59
20706985-1	2010	Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice.	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	15-40
20706985-1	2010	Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice.	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	42-45
20706985-3	2010	We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells.	Dioxins	54-60	aryl hydrocarbon receptor	Homo sapiens	43-46
20706985-3	2010	We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells.	Dioxins	54-60	interferon gamma	Homo sapiens	201-210
20706985-3	2010	We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells.	Dioxins	54-60	interleukin 22	Homo sapiens	226-231
20706985-3	2010	We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells.	Dioxins	54-60	interleukin 17A	Homo sapiens	264-270
20706985-3	2010	We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells.	Dioxins	54-60	CD4 molecule	Homo sapiens	285-288
20381523-11	2010	Lisa Opanashuk discussed how dioxin [TCDD] binding to the arylhydrocarbon receptor [AhR], a transcription factor that regulates xenobiotic metabolizing enzymes and growth factors, increased granule cell formation and apoptosis in the developing mouse cerebellum.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	58-82
20381523-11	2010	Lisa Opanashuk discussed how dioxin [TCDD] binding to the arylhydrocarbon receptor [AhR], a transcription factor that regulates xenobiotic metabolizing enzymes and growth factors, increased granule cell formation and apoptosis in the developing mouse cerebellum.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	84-87
20371273-0	2010	The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver.	Dioxins	65-71	period circadian clock 2	Mus musculus	4-37
20511231-1	2010	The aryl hydrocarbon receptor (AHR) is the ligand-activated transcription factor responsible for mediating the toxicological effects of dioxin and xenobiotic metabolism.	Dioxins	136-142	aryl hydrocarbon receptor	Homo sapiens	4-29
20511231-1	2010	The aryl hydrocarbon receptor (AHR) is the ligand-activated transcription factor responsible for mediating the toxicological effects of dioxin and xenobiotic metabolism.	Dioxins	136-142	aryl hydrocarbon receptor	Homo sapiens	31-34
20511231-6	2010	Here, we demonstrate that ligand-activated AHR is involved in priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream of the IL6 start site.	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	43-46
20511231-6	2010	Here, we demonstrate that ligand-activated AHR is involved in priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream of the IL6 start site.	Dioxins	119-125	interleukin 6	Homo sapiens	74-77
20511231-6	2010	Here, we demonstrate that ligand-activated AHR is involved in priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream of the IL6 start site.	Dioxins	119-125	interleukin 6	Homo sapiens	168-171
20511231-12	2010	It is likely that AHR-mediated priming is not restricted to the IL6 promoter and may contribute to the expression of a variety of genes, which do not have consensus dioxin response elements.	Dioxins	165-171	aryl hydrocarbon receptor	Homo sapiens	18-21
20231854-1	2010	The aryl hydrocarbon receptor (AhR) recognizes numerous small xenobiotic and natural molecules, such as dioxin and natural chemicals, and is involved in the metabolism of these compounds.	Dioxins	104-110	aryl-hydrocarbon receptor	Mus musculus	4-29
20231854-1	2010	The aryl hydrocarbon receptor (AhR) recognizes numerous small xenobiotic and natural molecules, such as dioxin and natural chemicals, and is involved in the metabolism of these compounds.	Dioxins	104-110	aryl-hydrocarbon receptor	Mus musculus	31-34
20460431-7	2010	By gene promoter analysis, chromatin immunoprecipitation, and electrophoretic mobility shift assays, an active, proximal dioxin-response element at -194/-190 base pairs upstream of the transcription start site of the human ABCG2 gene was identified.	Dioxins	121-127	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	223-228
20451541-1	2010	Dioxins such as 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) are common environmental contaminants known to regulate several genes via activation of the transcription factor aryl hydrocarbon receptor (AhR) associated with the development of numerous adverse biological effects.	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	171-196
20451541-1	2010	Dioxins such as 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) are common environmental contaminants known to regulate several genes via activation of the transcription factor aryl hydrocarbon receptor (AhR) associated with the development of numerous adverse biological effects.	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	198-201
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Dioxins	122-128	replication factor C subunit 1	Rattus norvegicus	73-77
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Dioxins	122-128	solute carrier family 19 member 1	Rattus norvegicus	79-86
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Dioxins	122-128	aryl hydrocarbon receptor	Rattus norvegicus	97-100
20451541-9	2010	As downregulation of pivotal Rfc1 activity results in functional folate deficiency associated with an elevated risk of cardiovascular diseases or carcinogenesis, our results indicate that deregulation of this essential transport pathway represents a novel regulatory mechanism how dioxins display their toxic effects through the Ah receptor.	Dioxins	281-288	replication factor C subunit 1	Rattus norvegicus	29-33
20451541-9	2010	As downregulation of pivotal Rfc1 activity results in functional folate deficiency associated with an elevated risk of cardiovascular diseases or carcinogenesis, our results indicate that deregulation of this essential transport pathway represents a novel regulatory mechanism how dioxins display their toxic effects through the Ah receptor.	Dioxins	281-288	aryl hydrocarbon receptor	Rattus norvegicus	329-340
20610613-3	2010	AhR detects various xenobiotics, such as drugs or endocrine disruptors (e.g. dioxin), and mediates transcriptional regulation of target genes such as those in the cytochrome P450 (CYP450) family.	Dioxins	77-83	aryl hydrocarbon receptor	Homo sapiens	0-3
20731829-11	2010	Evidence from this and other studies suggests that prenatal dioxin-like PCB exposure, including mono-ortho congeners, may interfere with brain development in utero.	Dioxins	60-66	pyruvate carboxylase	Homo sapiens	72-75
20449727-1	2010	The dioxin receptor, also known as arylhydrocarbon receptor (AhR), is a ligand-activated transcription factor that mediates the toxicity of dioxins and related environmental contaminants.	Dioxins	140-147	aryl hydrocarbon receptor	Homo sapiens	35-59
20449727-1	2010	The dioxin receptor, also known as arylhydrocarbon receptor (AhR), is a ligand-activated transcription factor that mediates the toxicity of dioxins and related environmental contaminants.	Dioxins	140-147	aryl hydrocarbon receptor	Homo sapiens	61-64
20106901-1	2010	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls.	Dioxins	188-195	aryl hydrocarbon receptor	Homo sapiens	4-29
20106901-1	2010	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls.	Dioxins	188-195	aryl hydrocarbon receptor	Homo sapiens	31-34
20598339-5	2010	The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs.	Dioxins	15-21	pyruvate carboxylase	Homo sapiens	27-30
20598339-5	2010	The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs.	Dioxins	116-122	pyruvate carboxylase	Homo sapiens	27-30
20598339-5	2010	The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs.	Dioxins	116-122	pyruvate carboxylase	Homo sapiens	27-30
20598339-5	2010	The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs.	Dioxins	116-122	pyruvate carboxylase	Homo sapiens	27-30
20598339-5	2010	The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs.	Dioxins	116-122	pyruvate carboxylase	Homo sapiens	27-30
20605043-1	2010	Dioxins are a group of highly toxic molecules that exert their toxicity through the activation of the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	102-127
20605043-1	2010	Dioxins are a group of highly toxic molecules that exert their toxicity through the activation of the aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	129-132
20371273-0	2010	The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver.	Dioxins	65-71	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	80-86
21787614-3	2010	Genetic variations in AhR result in different survivability under exposure to dioxin contamination, which might affect the genetic structure of wildlife populations through differential susceptibility to dioxin exposure.	Dioxins	78-84	aryl-hydrocarbon receptor	Mus musculus	22-25
20435334-1	2010	The exposure of Inuit people to polychlorinated biphenyls (PCBs) and chlorinated pesticides has been well characterised but little is known regarding their exposure to dioxin-like compounds, which induce toxic effects through binding to the aryl hydrocarbon receptor (AhR).	Dioxins	168-174	aryl hydrocarbon receptor	Homo sapiens	241-266
20435334-1	2010	The exposure of Inuit people to polychlorinated biphenyls (PCBs) and chlorinated pesticides has been well characterised but little is known regarding their exposure to dioxin-like compounds, which induce toxic effects through binding to the aryl hydrocarbon receptor (AhR).	Dioxins	168-174	aryl hydrocarbon receptor	Homo sapiens	268-271
20435334-7	2010	These results suggest that AhR-mediated transcriptional activity of Inuit plasma extracts is linked to their organochlorine body burden, most likely that of dioxin-like PCBs, polychlorinated dibenzo-p-dioxins and polychlorodibenzofurans.	Dioxins	157-163	aryl hydrocarbon receptor	Homo sapiens	27-30
20463971-5	2010	Within the interactome, many of these responses were connected to cytochrome P4501A (cyp1a) as well as other genes that were dioxin-regulated one day after exposure.	Dioxins	125-131	cytochrome P450, family 1, subfamily A	Danio rerio	85-90
20435555-2	2010	The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case of the method of concentration addition.	Dioxins	80-86	thyrotroph embryonic factor	Mus musculus	4-28
20435555-2	2010	The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case of the method of concentration addition.	Dioxins	80-86	thyrotroph embryonic factor	Mus musculus	30-33
20435556-4	2010	METHODS: AhR agonist activity was quantified in sera from dioxin-treated mice, commercial human sources, and polychlorinated biphenyl (PCB)-exposed Faroe Islanders using an AhR-driven reporter cell line.	Dioxins	58-64	aryl-hydrocarbon receptor	Mus musculus	9-12
20435556-7	2010	RESULTS: Mouse serum AhR agonist activity correlated with injected dioxin dose, thymic atrophy, and heptomegaly, validating the use of neat serum to assess AhR agonist activity.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	21-24
21787614-3	2010	Genetic variations in AhR result in different survivability under exposure to dioxin contamination, which might affect the genetic structure of wildlife populations through differential susceptibility to dioxin exposure.	Dioxins	204-210	aryl-hydrocarbon receptor	Mus musculus	22-25
21787614-4	2010	The aim of this study was to clarify the polymorphisms of AhR in Japanese field mice, Apodemus speciosus, and their functional differences in order to develop a molecular indicator for dioxin sensitivity.	Dioxins	185-191	aryl-hydrocarbon receptor	Mus musculus	58-61
20164297-3	2010	Pgrmc1 is induced by carcinogens, including dioxin, and is up-regulated in multiple types of cancer.	Dioxins	44-50	progesterone receptor membrane component 1	Homo sapiens	0-6
20354149-8	2010	These data also imply that human placentas and those fetal organs with high AhR expression (e.g., lung, kidney, liver, pancreas, and thymus gland) during fetal development are highly susceptible to environmental toxicants such as dioxin.	Dioxins	230-236	aryl hydrocarbon receptor	Homo sapiens	76-79
21787614-7	2010	In the functional analysis of AhR variants using transient reporter assays, a Gln to Arg mutation at amino acid 799 exhibited a significant decrease in the level of transactivational properties (p=0.015) which might modify the dioxin susceptibility of an individual.	Dioxins	227-233	aryl-hydrocarbon receptor	Mus musculus	30-33
19941261-2	2010	The detrimental effects of 2,3,7,8-tetrachlorodibenzo- P-dioxin (TCDD, one of the most common environmental dioxins) are mediated via the aryl hydrocarbon receptor (AhR).	Dioxins	108-115	aryl-hydrocarbon receptor	Mus musculus	165-168
20130022-1	2010	Experimental exposure of fish, birds, and rodents to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) causes multiple Ah receptor-mediated developmental abnormalities, an observation consistent with compelling evidence in human populations that TCDD exposure is responsible for a significant incidence of birth defects.	Dioxins	82-88	aryl-hydrocarbon receptor	Mus musculus	120-131
20130022-3	2010	We find that TCDD treatment causes expression changes in a number of homeobox genes concomitant with Ah receptor recruitment to the promoters of many of these genes, whether under naive or dioxin-activated conditions.	Dioxins	189-195	aryl-hydrocarbon receptor	Mus musculus	101-112
20130022-6	2010	These data identify potential pathways for dioxin to act as a developmental teratogen, possibly critical to cardiovascular development and disease, and provide molecular targets that may help us understand the molecular basis of Ah receptor-mediated developmental toxicity.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	229-240
20059580-1	2010	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates diverse dioxin toxicities.	Dioxins	101-107	aryl hydrocarbon receptor	Rattus norvegicus	4-29
20420666-0	2010	Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.	Dioxins	105-111	aryl hydrocarbon receptor	Rattus norvegicus	0-25
20420666-0	2010	Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.	Dioxins	105-111	aryl hydrocarbon receptor	Rattus norvegicus	27-30
20420666-4	2010	Rats expressing an AHR splice-variant lacking a portion of the transactivation domain are highly resistant to dioxin-induced toxicities.	Dioxins	110-116	aryl hydrocarbon receptor	Rattus norvegicus	19-22
20420666-7	2010	However, well-known AHR-regulated and dioxin-inducible genes such as CYP1A1, CYP1A2, and CYP1B1 remained fully responsive to TCDD in all strains/lines.	Dioxins	38-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	69-75
20420666-7	2010	However, well-known AHR-regulated and dioxin-inducible genes such as CYP1A1, CYP1A2, and CYP1B1 remained fully responsive to TCDD in all strains/lines.	Dioxins	38-44	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	77-83
20420666-7	2010	However, well-known AHR-regulated and dioxin-inducible genes such as CYP1A1, CYP1A2, and CYP1B1 remained fully responsive to TCDD in all strains/lines.	Dioxins	38-44	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	89-95
20384380-5	2010	In multivariate regression models where otoacoustic measures were modeled as a function of log (base 10) PCB concentrations with adjustment for gender, age, and site of examination, dioxin-like PCBs, nondioxin-like PCBs and a PCB grouping targeting upregulation of hepatic uridine 5"-diphospho-glucuronosyltransferase were significantly associated with lower TEOAE powers at 1000 and 1500 Hz.	Dioxins	182-188	pyruvate carboxylase	Homo sapiens	194-197
20116417-4	2010	The reverse is the case for the mouse embryonic fibroblast cell line C3H10T1/2, in which Cyp1b1 is induced to very high levels by dioxin, but the levels of Cyp1a1 mRNA are extremely low and not inducible by dioxin.	Dioxins	130-136	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	89-95
20116417-4	2010	The reverse is the case for the mouse embryonic fibroblast cell line C3H10T1/2, in which Cyp1b1 is induced to very high levels by dioxin, but the levels of Cyp1a1 mRNA are extremely low and not inducible by dioxin.	Dioxins	207-213	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	89-95
20116417-5	2010	However, dioxin treatment leads to the recruitment of AhR to the enhancer regions of both genes in both cell lines.	Dioxins	9-15	aryl-hydrocarbon receptor	Mus musculus	54-57
20359356-2	2010	This humoral immune response is suppressed by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds, which belong to the family of aryl hydrocarbon receptor (AhR) agonists.	Dioxins	105-111	aryl hydrocarbon receptor	Homo sapiens	182-207
20359356-2	2010	This humoral immune response is suppressed by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds, which belong to the family of aryl hydrocarbon receptor (AhR) agonists.	Dioxins	105-111	aryl hydrocarbon receptor	Homo sapiens	209-212
20153503-9	2010	Dioxin induced mRNAs of dioxin-responsive genes and EROD activity in an AhR-dependent manner.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	72-75
20153503-9	2010	Dioxin induced mRNAs of dioxin-responsive genes and EROD activity in an AhR-dependent manner.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	72-75
20176394-4	2010	Higher PCDD/F concentrations were observed in the winter, whereas higher dioxin-like PCB concentrations were found in the summer.	Dioxins	73-79	pyruvate carboxylase	Homo sapiens	85-88
20401977-1	2010	BACKGROUND: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like chemicals are mediated through binding-dependent activation of the cytosolic aryl hydrocarbon receptor (AHR).	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	164-189
20401977-1	2010	BACKGROUND: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like chemicals are mediated through binding-dependent activation of the cytosolic aryl hydrocarbon receptor (AHR).	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	191-194
20401977-2	2010	The human AHR is a low-affinity receptor relative to most rodents, but some reports suggest that there may be individuals with polymorphic high-affinity receptors, thereby possibly increasing the sensitivity to dioxins in such people.	Dioxins	211-218	aryl hydrocarbon receptor	Homo sapiens	10-13
19959279-10	2010	The dioxin-like PCB-TEQ had concentrations ranging from 0.03 to 0.08 pg TEQ g(-1) dw, mainly from PCB126.	Dioxins	4-10	pyruvate carboxylase	Homo sapiens	16-19
20116417-0	2010	Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.	Dioxins	31-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-52
20116417-0	2010	Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.	Dioxins	31-37	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	57-63
20116417-1	2010	The xenobiotic metabolizing enzymes Cyp1a1 and Cyp1b1 can be induced by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via the aryl hydrocarbon receptor (AhR).	Dioxins	133-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	36-42
20116417-1	2010	The xenobiotic metabolizing enzymes Cyp1a1 and Cyp1b1 can be induced by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via the aryl hydrocarbon receptor (AhR).	Dioxins	133-139	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	47-53
20116417-1	2010	The xenobiotic metabolizing enzymes Cyp1a1 and Cyp1b1 can be induced by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via the aryl hydrocarbon receptor (AhR).	Dioxins	133-139	aryl-hydrocarbon receptor	Mus musculus	157-182
20116417-1	2010	The xenobiotic metabolizing enzymes Cyp1a1 and Cyp1b1 can be induced by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via the aryl hydrocarbon receptor (AhR).	Dioxins	133-139	aryl-hydrocarbon receptor	Mus musculus	184-187
20116417-3	2010	In the mouse hepatoma cell line Hepa1c1c7 (Hepa-1), the Cyp1a1 gene is induced to very high levels by dioxin, but the levels of Cyp1b1 mRNA are extremely low and are not inducible by dioxin.	Dioxins	102-108	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	56-62
20116417-3	2010	In the mouse hepatoma cell line Hepa1c1c7 (Hepa-1), the Cyp1a1 gene is induced to very high levels by dioxin, but the levels of Cyp1b1 mRNA are extremely low and are not inducible by dioxin.	Dioxins	183-189	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	56-62
21918637-6	2010	The average profile resembles a mixture of Aroclor 1242 and Aroclor 1254, and includes many congeners that have been identified as being aryl hydrocarbon receptor (AhR) agonists (dioxin-like) and/or neurotoxins.	Dioxins	179-185	aryl hydrocarbon receptor	Homo sapiens	137-162
21918637-6	2010	The average profile resembles a mixture of Aroclor 1242 and Aroclor 1254, and includes many congeners that have been identified as being aryl hydrocarbon receptor (AhR) agonists (dioxin-like) and/or neurotoxins.	Dioxins	179-185	aryl hydrocarbon receptor	Homo sapiens	164-167
20059580-1	2010	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates diverse dioxin toxicities.	Dioxins	101-107	aryl hydrocarbon receptor	Rattus norvegicus	31-34
19896476-5	2010	Persistent AhR activation by dioxin, a potent xenobiotic AhR agonist, results in altered numbers and function of HSCs in mouse bone marrow.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	11-14
20572746-10	2010	An observed trend to an opposite direction between the dioxin-like AhR and ER activity supports the perception of that dioxins exert an antiestrogen effect.	Dioxins	55-61	aryl hydrocarbon receptor	Homo sapiens	67-70
20572746-10	2010	An observed trend to an opposite direction between the dioxin-like AhR and ER activity supports the perception of that dioxins exert an antiestrogen effect.	Dioxins	119-126	aryl hydrocarbon receptor	Homo sapiens	67-70
19896476-5	2010	Persistent AhR activation by dioxin, a potent xenobiotic AhR agonist, results in altered numbers and function of HSCs in mouse bone marrow.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	57-60
19941898-1	2010	The aryl-hydrocarbon-receptor (AHR) is involved as receptor and transcription factor in dioxin toxicity.	Dioxins	88-94	aryl hydrocarbon receptor	Homo sapiens	4-29
20152453-0	2010	Influence of the solvent quality on the AhR mediated Procept assay measurement of dioxin and dioxin-like compounds.	Dioxins	82-88	aryl hydrocarbon receptor	Homo sapiens	40-43
20152453-0	2010	Influence of the solvent quality on the AhR mediated Procept assay measurement of dioxin and dioxin-like compounds.	Dioxins	93-99	aryl hydrocarbon receptor	Homo sapiens	40-43
20152453-1	2010	Polychlorodibenzo-p-dioxins, polychorodibenzofurans and "dioxin-like" polychlorinated biphenyls are widespread persistent organic pollutants sharing a similar toxicological pathway mediated by the aryl-hydrocarbon receptor (AhR).	Dioxins	20-26	aryl hydrocarbon receptor	Homo sapiens	197-222
20152453-1	2010	Polychlorodibenzo-p-dioxins, polychorodibenzofurans and "dioxin-like" polychlorinated biphenyls are widespread persistent organic pollutants sharing a similar toxicological pathway mediated by the aryl-hydrocarbon receptor (AhR).	Dioxins	20-26	aryl hydrocarbon receptor	Homo sapiens	224-227
20152453-4	2010	In this study, the influence of solvent grade quality on the response of a DNA-binding AhR mediated assay used for screening dioxins has been investigated.	Dioxins	125-132	aryl hydrocarbon receptor	Homo sapiens	87-90
20007409-0	2010	Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.	Dioxins	98-104	aryl-hydrocarbon receptor	Mus musculus	32-57
19941898-1	2010	The aryl-hydrocarbon-receptor (AHR) is involved as receptor and transcription factor in dioxin toxicity.	Dioxins	88-94	aryl hydrocarbon receptor	Homo sapiens	31-34
19778576-1	2010	The aryl hydrocarbon receptor (AhR), in complex with its binding partner ARNT, mediates the cellular response to xenobiotic compounds such as the environmental pollutant dioxin.	Dioxins	170-176	aryl hydrocarbon receptor	Homo sapiens	4-29
19778576-1	2010	The aryl hydrocarbon receptor (AhR), in complex with its binding partner ARNT, mediates the cellular response to xenobiotic compounds such as the environmental pollutant dioxin.	Dioxins	170-176	aryl hydrocarbon receptor	Homo sapiens	31-34
19778576-1	2010	The aryl hydrocarbon receptor (AhR), in complex with its binding partner ARNT, mediates the cellular response to xenobiotic compounds such as the environmental pollutant dioxin.	Dioxins	170-176	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	73-77
19903824-4	2010	AHR-mediated toxicity is primarily derived from AHR binding to its dioxin response element (DRE) and driving expression of CYP1 family members, which have the capacity to metabolize procarcinogens to genotoxic carcinogens.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	0-3
20060563-0	2010	Effects of dioxin isomers on induction of AhRs and CYP1A1 in early developmental stage embryos of medaka (Oryzias latipes).	Dioxins	11-17	cytochrome P450 1A1	Oryzias latipes	51-57
20060563-1	2010	The aryl hydrocarbon receptor (AhR) binds to polyaromatic compounds, including dioxins, and enhances the expression of several target genes, including drug-metabolizing cytochrome P450s (CYP1As).	Dioxins	79-86	aryl hydrocarbon receptor 1b	Oryzias latipes	4-29
20060563-1	2010	The aryl hydrocarbon receptor (AhR) binds to polyaromatic compounds, including dioxins, and enhances the expression of several target genes, including drug-metabolizing cytochrome P450s (CYP1As).	Dioxins	79-86	aryl hydrocarbon receptor 1b	Oryzias latipes	31-34
20060563-6	2010	In this study, we investigated the toxicity of 13 dioxin isomers, including 2378T4CDD, and the induced expression of AhRs, AhRR, and CYP1A1 (CYP1A1_ORYLA) in the early life stages of medaka embryos.	Dioxins	50-56	cytochrome P450 1A1	Oryzias latipes	133-139
19903824-4	2010	AHR-mediated toxicity is primarily derived from AHR binding to its dioxin response element (DRE) and driving expression of CYP1 family members, which have the capacity to metabolize procarcinogens to genotoxic carcinogens.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	48-51
20190398-2	2010	Several reports have shown that the AhR plays an important role in the control of cell-cycle progression, and this function is thought to be partly associated with the tumor promotion activity of dioxin.	Dioxins	196-202	aryl hydrocarbon receptor	Homo sapiens	36-39
20146706-0	2010	Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	47-72
19850319-4	2010	The sums of the concentrations of 56 non-dioxin-like PCB congeners that were measured in the subjects" blood and breast milk were 43-445 (mean: 120, median: 106) and 34-366 (mean: 90, median: 81) ng g(-1)lipid, respectively, indicating that the total TEQ concentration and the total concentration of 56 non-dioxin-like PCB congeners in the maternal blood were notably higher than those in the breast milk.	Dioxins	41-47	pyruvate carboxylase	Homo sapiens	53-56
20057149-1	2010	The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by dioxin and related xenobiotics.	Dioxins	83-89	aryl hydrocarbon receptor	Homo sapiens	4-29
20057149-1	2010	The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by dioxin and related xenobiotics.	Dioxins	83-89	aryl hydrocarbon receptor	Homo sapiens	31-34
19850319-5	2010	Statistically significant correlations were observed between maternal age and the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs or the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and significant correlations were also observed between maternal age and the total TEQ concentration of these dioxin-like compounds or the total concentration of 56 PCB congeners in breast milk.	Dioxins	127-133	pyruvate carboxylase	Homo sapiens	139-142
19850319-5	2010	Statistically significant correlations were observed between maternal age and the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs or the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and significant correlations were also observed between maternal age and the total TEQ concentration of these dioxin-like compounds or the total concentration of 56 PCB congeners in breast milk.	Dioxins	181-187	pyruvate carboxylase	Homo sapiens	193-196
19850319-5	2010	Statistically significant correlations were observed between maternal age and the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs or the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and significant correlations were also observed between maternal age and the total TEQ concentration of these dioxin-like compounds or the total concentration of 56 PCB congeners in breast milk.	Dioxins	181-187	pyruvate carboxylase	Homo sapiens	193-196
19850319-6	2010	The total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs in maternal blood showed a close correlation to that in subjects" breast milk, and there was also good correlation between the total concentration of 56 non-dioxin-like PCB congeners in maternal blood and that in subjects" breast milk.	Dioxins	49-55	pyruvate carboxylase	Homo sapiens	61-64
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	121-127	pyruvate carboxylase	Homo sapiens	133-136
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	121-127	pyruvate carboxylase	Homo sapiens	188-191
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	176-182	pyruvate carboxylase	Homo sapiens	133-136
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	176-182	pyruvate carboxylase	Homo sapiens	188-191
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	176-182	pyruvate carboxylase	Homo sapiens	133-136
19850319-7	2010	Pearson and Spearman correlation analyses showed a relationship between the total TEQ concentration of PCDDs, PCDFs, and dioxin-like PCBs and the total concentration of 56 non-dioxin-like PCB congeners in maternal blood, and also showed an association between the total TEQ concentration of these dioxin-like compounds and the total concentration of 56 PCB congeners in breast milk.	Dioxins	176-182	pyruvate carboxylase	Homo sapiens	188-191
19850319-10	2010	These findings suggested that hexaCB-153 may be an indicator of total TEQ concentrations of PCDDs, PCDFs, and dioxin-like PCBs and total concentrations of 56 non-dioxin-like PCB congeners in blood and breast milk of primiparous mothers.	Dioxins	110-116	pyruvate carboxylase	Homo sapiens	122-125
20464981-3	2010	Following chemical-physical and mechanistics considerations, in particular the same AhR-mediated action, for two other dioxin-like compounds, the PCB126 and the PeCDF the classification in group 1 was suggested.	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	84-87
20010210-2	2010	Little is known about how serum dioxins might affect insulin resistance, a hallmark of type 2 diabetes.	Dioxins	32-39	insulin	Homo sapiens	53-60
20010210-3	2010	We examined the association between exposure to dioxins and insulin resistance.	Dioxins	48-55	insulin	Homo sapiens	60-67
20010210-7	2010	RESULTS: Participants with insulin resistance (index at or above the 75th percentile) had higher dioxin levels (24.3 vs. 19.8 pg WHO(98)-TEQ(DF)/g lipid) than those without insulin resistance.	Dioxins	97-103	insulin	Homo sapiens	27-34
20010210-10	2010	Groups with serum dioxin levels higher than 20.5 pg WHO(98)-TEQ(DF)/g lipid had higher insulin resistance (adjusted odds ratios of 2.7, 3.5, and 5.0 for 50th to <75th, 75th to <90th, and >or=90th percentile, respectively) compared with the reference group (<9.6 pg WHO(98)-TEQ(DF)/g lipid [< 10th percentile]).	Dioxins	18-24	insulin	Homo sapiens	87-94
20010210-11	2010	CONCLUSIONS: After adjusting for confounding factors, we found a positive association between serum dioxins and the prevalence of insulin resistance.	Dioxins	100-107	insulin	Homo sapiens	130-137
20020262-6	2010	Receptor-mediated mechanisms involving the reversible binding of xenobiotic substrates to a specific receptor are exemplified herein by the interaction of the environmental chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or "dioxin") with the cytosolic aryl hydrocarbon receptor (AHR), which translocates to the nucleus and, in association with other proteins, binds to AH-responsive elements (AHREs) in numerous genes, initiating changes in gene transcription that can perturb development.	Dioxins	211-217	aryl hydrocarbon receptor	Homo sapiens	256-281
19744782-3	2009	PCB-77 concentration was the highest among dioxin-like PCBs and PCB-126 contributed mostly to the WHO-TEQ.	Dioxins	43-49	pyruvate carboxylase	Homo sapiens	0-3
20020262-6	2010	Receptor-mediated mechanisms involving the reversible binding of xenobiotic substrates to a specific receptor are exemplified herein by the interaction of the environmental chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or "dioxin") with the cytosolic aryl hydrocarbon receptor (AHR), which translocates to the nucleus and, in association with other proteins, binds to AH-responsive elements (AHREs) in numerous genes, initiating changes in gene transcription that can perturb development.	Dioxins	211-217	aryl hydrocarbon receptor	Homo sapiens	283-286
19828881-5	2010	Therefore, we conducted a dioxin response element reporter-based screen to assess the AHR activity associated with a range of flavonoid compounds.	Dioxins	26-32	aryl hydrocarbon receptor	Homo sapiens	86-89
20373220-4	2010	The dioxin-like model predicts a mechanism that requires a favourable interaction with a receptor nucleophilic site in the central part of the ligand and with electrophilic sites at both sides of the principal molecular axis, whereas the biphenyl-like model predicted a stacking-type interaction with the aryl hydrocarbon receptor allowing electron charge transfer from the receptor to the ligand.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	305-330
19744782-3	2009	PCB-77 concentration was the highest among dioxin-like PCBs and PCB-126 contributed mostly to the WHO-TEQ.	Dioxins	43-49	pyruvate carboxylase	Homo sapiens	55-58
19744782-4	2009	The ratios of dioxin-like PCBs in the total PCB concentrations in the flue gas varied between 11.7% and 26.0% (the average value is 18.7%).	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
19751709-0	2009	Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells.	Dioxins	4-10	MDM2 proto-oncogene	Homo sapiens	35-39
19751709-0	2009	Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells.	Dioxins	4-10	tumor protein p53	Homo sapiens	68-71
19825792-4	2009	Supporting this concept, serum GGT within its normal range had clear dose-response associations with a variety of chemicals such as lead, cadmium, organochlorine pesticides, and dioxin.	Dioxins	178-184	gamma-glutamyltransferase light chain family member 3	Homo sapiens	31-34
19747074-0	2009	The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	14-44
19747074-1	2009	The mammalian Ah receptor (AhR) is a ligand-activated transcription factor with multiple functions in adaptive metabolism, development and dioxin toxicity in a variety of organs and cell systems.	Dioxins	139-145	aryl hydrocarbon receptor	Homo sapiens	14-25
19747074-1	2009	The mammalian Ah receptor (AhR) is a ligand-activated transcription factor with multiple functions in adaptive metabolism, development and dioxin toxicity in a variety of organs and cell systems.	Dioxins	139-145	aryl hydrocarbon receptor	Homo sapiens	27-30
19781569-0	2009	The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor"s alternative physiological roles.	Dioxins	18-24	aryl-hydrocarbon receptor	Mus musculus	70-95
19686824-6	2009	The levels of CYP1A1, CYP1A2, CY2C9 and CYP3A4 mRNAs were not altered by Zolpidem, whereas model inducers dioxin and rifampicin significantly induced CYP1A and CYP2/3 gene expression, respectively.	Dioxins	106-112	peptidylprolyl isomerase F	Homo sapiens	160-166
19759094-2	2009	Ahr-null mice are refractory to the toxic effects of dioxin exposure.	Dioxins	53-59	aryl-hydrocarbon receptor	Mus musculus	0-3
19648964-4	2009	Here, we show that dioxin-mediated activation of Ahr induces Nedd9/Hef1/Cas-L, a member of the Cas protein family recently identified as a metastasis marker.	Dioxins	19-25	aryl hydrocarbon receptor	Homo sapiens	49-52
19648964-4	2009	Here, we show that dioxin-mediated activation of Ahr induces Nedd9/Hef1/Cas-L, a member of the Cas protein family recently identified as a metastasis marker.	Dioxins	19-25	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	61-66
19648964-4	2009	Here, we show that dioxin-mediated activation of Ahr induces Nedd9/Hef1/Cas-L, a member of the Cas protein family recently identified as a metastasis marker.	Dioxins	19-25	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	67-71
19648964-4	2009	Here, we show that dioxin-mediated activation of Ahr induces Nedd9/Hef1/Cas-L, a member of the Cas protein family recently identified as a metastasis marker.	Dioxins	19-25	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	72-77
19648964-6	2009	Moreover, using RNA interference, we show that Nedd9/Hef1/Cas-L mediates the dioxin-elicited changes related to cell plasticity, including alterations of cellular adhesion and shape, cytoskeleton reorganization, and increased cell migration.	Dioxins	77-83	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	47-52
19648964-6	2009	Moreover, using RNA interference, we show that Nedd9/Hef1/Cas-L mediates the dioxin-elicited changes related to cell plasticity, including alterations of cellular adhesion and shape, cytoskeleton reorganization, and increased cell migration.	Dioxins	77-83	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	53-57
19648964-6	2009	Moreover, using RNA interference, we show that Nedd9/Hef1/Cas-L mediates the dioxin-elicited changes related to cell plasticity, including alterations of cellular adhesion and shape, cytoskeleton reorganization, and increased cell migration.	Dioxins	77-83	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	58-63
19736056-8	2009	CONCLUSIONS: CYP1B1 activates chemicals such as polycyclic aromatic hydrocarbons and dioxins to create oxidized, reactive intermediates, and higher gene activity has been shown for the G allele.	Dioxins	85-92	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	13-19
19759094-0	2009	Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	90-93
19759094-1	2009	The aryl hydrocarbon receptor (AHR) is a widely expressed ligand-dependent transcription factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons.	Dioxins	132-139	aryl-hydrocarbon receptor	Mus musculus	4-29
19759094-1	2009	The aryl hydrocarbon receptor (AHR) is a widely expressed ligand-dependent transcription factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons.	Dioxins	132-139	aryl-hydrocarbon receptor	Mus musculus	31-34
19759094-4	2009	To address the latter issue, we defined and compared transcriptional responses to dioxin exposure in the liver and kidney of wild-type and Ahr-null adult C57BL/6J mice treated with either 2,3,7,8-tetrachlorodibenzo-p-dioxin or corn-oil vehicle.	Dioxins	82-88	aryl-hydrocarbon receptor	Mus musculus	139-142
19759094-5	2009	In both tissues, essentially all effects of dioxin on hepatic mRNA levels were mediated by the AHR.	Dioxins	44-50	aryl-hydrocarbon receptor	Mus musculus	95-98
19759094-6	2009	Although 297 genes were altered by dioxin exposure in the liver, only 17 were changed in the kidney, including a number of well-established AHR target genes.	Dioxins	35-41	aryl-hydrocarbon receptor	Mus musculus	140-143
19640236-1	2009	INTRODUCTION: The aryl hydrocarbon receptor (AhR) is a cellular signaling molecule infamous for mediating the toxicity of dioxins and related compounds.	Dioxins	122-129	aryl hydrocarbon receptor	Homo sapiens	18-43
19716514-3	2009	It has been shown that the AhR bonds to a DNA sequence called the dioxin response element (DRE), which controls the expression of battery genes.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	27-30
19953395-4	2009	Epidemiologic data on human and ecological dioxin exposures have revealed a common pattern of biological response among vertebrate species, which is mediated through activation of the Aryl hydrocarbon Receptor (AhR).	Dioxins	43-49	aryl hydrocarbon receptor	Homo sapiens	184-209
19953395-4	2009	Epidemiologic data on human and ecological dioxin exposures have revealed a common pattern of biological response among vertebrate species, which is mediated through activation of the Aryl hydrocarbon Receptor (AhR).	Dioxins	43-49	aryl hydrocarbon receptor	Homo sapiens	211-214
19744969-3	2009	The aim of our review is to present a summary of the biological effects of dioxin and its aryl hydrocarbon receptor, and to reassess the evidence presented in published, in vitro, preclinical and epidemiological studies regarding the association between dioxins and endometriosis.	Dioxins	75-81	aryl hydrocarbon receptor	Homo sapiens	90-115
19574409-0	2009	Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	41-66
19574409-0	2009	Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	71-94
19574409-7	2009	Our findings demonstrate not only that dioxin induces the recruitment of ERalpha to AHR target genes but also that AHR is recruited to estrogen-responsive regions in a gene-specific manner, suggesting that AHR utilizes both of these mechanisms to modulate estrogen-dependent signaling.	Dioxins	39-45	estrogen receptor 1	Homo sapiens	73-80
19574409-7	2009	Our findings demonstrate not only that dioxin induces the recruitment of ERalpha to AHR target genes but also that AHR is recruited to estrogen-responsive regions in a gene-specific manner, suggesting that AHR utilizes both of these mechanisms to modulate estrogen-dependent signaling.	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	84-87
19628587-0	2009	Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.	Dioxins	95-101	aryl hydrocarbon receptor	Homo sapiens	41-44
19628587-0	2009	Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.	Dioxins	95-101	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
19699679-3	2009	AhR recognizes numerous small xenobiotic and natural molecules, such as dioxin and the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.	Dioxins	72-78	aryl hydrocarbon receptor	Homo sapiens	0-3
19699679-4	2009	Although AhR is best known for mediating dioxin toxicity, knockout studies have indicated that AhR also plays a role in normal physiology, including certain immune responses.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	9-12
19699679-4	2009	Although AhR is best known for mediating dioxin toxicity, knockout studies have indicated that AhR also plays a role in normal physiology, including certain immune responses.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	95-98
19667482-1	2009	A reporter gene assay (RGA) that uses a mouse liver recombinant Hepa1c1c7 containing the firefly luciferase gene was developed to screen for dioxins in human plasma.	Dioxins	141-148	solute carrier family 50 (sugar transporter), member 1	Mus musculus	23-26
19640236-1	2009	INTRODUCTION: The aryl hydrocarbon receptor (AhR) is a cellular signaling molecule infamous for mediating the toxicity of dioxins and related compounds.	Dioxins	122-129	aryl hydrocarbon receptor	Homo sapiens	45-48
19640236-3	2009	TOXICITY: The AhR is essential for the toxicity of dioxins and related chemicals.	Dioxins	51-58	aryl hydrocarbon receptor	Homo sapiens	14-17
19640236-4	2009	The AhR mediates the exquisite sensitivity of animals to dioxins, where as little as 2 ng/kg/day can yield striking adverse effects.	Dioxins	57-64	aryl hydrocarbon receptor	Homo sapiens	4-7
19640236-5	2009	PHYSIOLOGICAL ROLE OF AHR: The wide variety of adverse effects of dioxin argues for an important role of the AhR in a variety of physiological systems.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	22-25
19640236-5	2009	PHYSIOLOGICAL ROLE OF AHR: The wide variety of adverse effects of dioxin argues for an important role of the AhR in a variety of physiological systems.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	109-112
20021851-0	2009	[Construction of the dioxin bioassay method based on the clonal expressed aryl hydrocarbon receptor system].	Dioxins	21-27	aryl-hydrocarbon receptor	Mus musculus	74-99
19460354-0	2009	Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.	Dioxins	31-37	estrogen receptor 1	Homo sapiens	61-84
19460354-0	2009	Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.	Dioxins	31-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
19460354-0	2009	Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.	Dioxins	31-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	99-105
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	estrogen receptor 1	Homo sapiens	79-102
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	estrogen receptor 1	Homo sapiens	104-111
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	estrogen receptor 1	Homo sapiens	158-165
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	169-187
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	189-195
19460354-1	2009	We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells.	Dioxins	126-132	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	201-207
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	30-37
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	48-55
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	48-55
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	48-55
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	48-55
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-187
19460354-2	2009	Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1.	Dioxins	0-6	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	192-198
19460354-4	2009	Expression of ERalpha-WT increased dioxin-induced CYP1A1 and CYP1B1-regulated reporter activity, and CYP1A1 and CYP1B1 mRNA levels.	Dioxins	35-41	estrogen receptor 1	Homo sapiens	14-21
19460354-4	2009	Expression of ERalpha-WT increased dioxin-induced CYP1A1 and CYP1B1-regulated reporter activity, and CYP1A1 and CYP1B1 mRNA levels.	Dioxins	35-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
19460354-4	2009	Expression of ERalpha-WT increased dioxin-induced CYP1A1 and CYP1B1-regulated reporter activity, and CYP1A1 and CYP1B1 mRNA levels.	Dioxins	35-41	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	61-67
19460354-6	2009	Our data show that the AF2 domain contributes to dioxin-induced recruitment of ERalpha to AHR target genes, but that both the AF1 and AF2 domains are required for ERalpha-dependent increases in AHR activity.	Dioxins	49-55	estrogen receptor 1	Homo sapiens	79-86
19460354-6	2009	Our data show that the AF2 domain contributes to dioxin-induced recruitment of ERalpha to AHR target genes, but that both the AF1 and AF2 domains are required for ERalpha-dependent increases in AHR activity.	Dioxins	49-55	aryl hydrocarbon receptor	Homo sapiens	90-93
19604390-1	2009	BACKGROUND: Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants.	Dioxins	217-223	aryl hydrocarbon receptor	Homo sapiens	108-132
19604390-1	2009	BACKGROUND: Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants.	Dioxins	217-223	aryl hydrocarbon receptor	Homo sapiens	134-137
19584540-1	2009	Dioxins enter the body mainly through the diet, bind to the aryl hydrocarbon receptor (AhR), and cause various toxicological effects.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	60-85
19584540-1	2009	Dioxins enter the body mainly through the diet, bind to the aryl hydrocarbon receptor (AhR), and cause various toxicological effects.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	87-90
19182260-0	2009	Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization.	Dioxins	11-17	vascular endothelial growth factor A	Mus musculus	21-55
19182260-0	2009	Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization.	Dioxins	11-17	vascular endothelial growth factor A	Mus musculus	57-61
19182260-12	2009	CONCLUSIONS: The authors demonstrate that dioxins are among the factors inducing abnormal vascularization in the eye through VEGF production mediated by AhR signaling.	Dioxins	42-49	vascular endothelial growth factor A	Mus musculus	125-129
19182260-12	2009	CONCLUSIONS: The authors demonstrate that dioxins are among the factors inducing abnormal vascularization in the eye through VEGF production mediated by AhR signaling.	Dioxins	42-49	aryl-hydrocarbon receptor	Mus musculus	153-156
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-273	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	140-159
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-273	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	166-172
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-273	aryl-hydrocarbon receptor	Mus musculus	231-256
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-272	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	140-159
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-272	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	166-172
19653942-3	2009	The objective of this study was to determine whether the presence of cotton balls, provided to mice for enrichment, caused induction of the cytochrome P450 1A1 gene (Cyp1A1), which typically is stimulated through activation of the aryl hydrocarbon receptor (AhR) by dioxins and dioxin-like compounds.	Dioxins	266-272	aryl-hydrocarbon receptor	Mus musculus	231-256
19653942-6	2009	These results suggest that cotton balls are potentially contaminated with dioxins and/or dioxin-like compounds that act as potent inducers of Cyp1a1 in laboratory animals if used as nesting material.	Dioxins	74-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	142-148
19653942-6	2009	These results suggest that cotton balls are potentially contaminated with dioxins and/or dioxin-like compounds that act as potent inducers of Cyp1a1 in laboratory animals if used as nesting material.	Dioxins	74-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	142-148
19376845-0	2009	Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes.	Dioxins	21-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
19376845-0	2009	Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes.	Dioxins	21-27	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
19376845-0	2009	Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes.	Dioxins	21-27	aryl hydrocarbon receptor	Homo sapiens	107-132
19376845-2	2009	Resveratrol (3,4,5-trihydroxystelbine) is a naturally occurring compound that has been shown in a number of studies to inhibit the induction of CYP1A1 and CYP1B1 by dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin), but the mechanism(s) of resveratrol inhibition is controversial.	Dioxins	165-171	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-150
19376845-2	2009	Resveratrol (3,4,5-trihydroxystelbine) is a naturally occurring compound that has been shown in a number of studies to inhibit the induction of CYP1A1 and CYP1B1 by dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin), but the mechanism(s) of resveratrol inhibition is controversial.	Dioxins	165-171	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	155-161
19376845-3	2009	In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2.	Dioxins	28-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
19376845-3	2009	In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2.	Dioxins	28-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	82-88
19376845-3	2009	In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2.	Dioxins	28-34	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-100
19376845-3	2009	In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2.	Dioxins	28-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	161-167
19376845-3	2009	In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2.	Dioxins	28-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	172-178
19376845-5	2009	Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings.	Dioxins	87-93	aryl hydrocarbon receptor	Homo sapiens	121-146
19376845-5	2009	Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings.	Dioxins	87-93	aryl hydrocarbon receptor	Homo sapiens	148-151
19376845-5	2009	Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings.	Dioxins	87-93	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	197-201
19376845-5	2009	Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings.	Dioxins	87-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	296-302
19376845-5	2009	Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings.	Dioxins	87-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	307-313
19376845-7	2009	Our studies thus indicate that resveratrol inhibits dioxin induction of the CYP1 family members either by directly or indirectly inhibiting the recruitment of the transcription factors AHR and ARNT to the xenobiotic response elements of the corresponding genes.	Dioxins	52-58	aryl hydrocarbon receptor	Homo sapiens	185-188
19376845-7	2009	Our studies thus indicate that resveratrol inhibits dioxin induction of the CYP1 family members either by directly or indirectly inhibiting the recruitment of the transcription factors AHR and ARNT to the xenobiotic response elements of the corresponding genes.	Dioxins	52-58	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	193-197
19447539-1	2009	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a known disruptor of B-cell differentiation and a ligand for the aryl hydrocarbon receptor (AhR), induces binding of the AhR to dioxin responsive elements (DRE) in sensitive genes.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	109-134
19083138-4	2009	The sums of the six non-dioxin-like indicator PCB (NDL-PCB) congeners were 0.13 to 9.3 ng/g fw and 1.2 to 1.9 ng/g fw, respectively.	Dioxins	24-30	pyruvate carboxylase	Bos taurus	46-49
19447539-1	2009	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a known disruptor of B-cell differentiation and a ligand for the aryl hydrocarbon receptor (AhR), induces binding of the AhR to dioxin responsive elements (DRE) in sensitive genes.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	136-139
19447539-1	2009	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a known disruptor of B-cell differentiation and a ligand for the aryl hydrocarbon receptor (AhR), induces binding of the AhR to dioxin responsive elements (DRE) in sensitive genes.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	165-168
19375780-6	2009	Qualitative and quantitative measurements of 49 PCB congeners was obtained by HRGC-ECD analysis and total dioxin-like activity using the CAFLUX bioassay.	Dioxins	106-112	pyruvate carboxylase	Homo sapiens	48-51
19500377-0	2009	Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study.	Dioxins	10-17	aryl hydrocarbon receptor	Homo sapiens	75-100
19592671-1	2009	The aryl hydrocarbon receptor (AHR) mediates most, if not all, of the many toxicological effects of the environmental pollutant 2,3,7,8-tetrachlorodibenzo- p-dioxin [(TCDD) or dioxin].	Dioxins	158-164	aryl hydrocarbon receptor	Homo sapiens	4-29
19370474-5	2009	Supporting this concept, it was recently reported that serum GGT within its reference range was linearly associated with important environmental pollutants, including lead, cadmium, dioxin and organochlorine pesticides.	Dioxins	182-188	gamma-glutamyltransferase light chain family member 3	Homo sapiens	61-64
19592671-2	2009	The "classical" pathway of AHR action involves dimerization of the liganded AHR with the aryl hydrocarbon nuclear translocator (ARNT) protein, and the AHR-ARNT dimer specifically associates with the enhancer regions of dioxin-responsive genes, leading to their increased transcription.	Dioxins	219-225	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	155-159
19592671-1	2009	The aryl hydrocarbon receptor (AHR) mediates most, if not all, of the many toxicological effects of the environmental pollutant 2,3,7,8-tetrachlorodibenzo- p-dioxin [(TCDD) or dioxin].	Dioxins	158-164	aryl hydrocarbon receptor	Homo sapiens	31-34
19592671-3	2009	Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin-mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene.	Dioxins	88-94	epidermal growth factor	Homo sapiens	44-67
19592671-2	2009	The "classical" pathway of AHR action involves dimerization of the liganded AHR with the aryl hydrocarbon nuclear translocator (ARNT) protein, and the AHR-ARNT dimer specifically associates with the enhancer regions of dioxin-responsive genes, leading to their increased transcription.	Dioxins	219-225	aryl hydrocarbon receptor	Homo sapiens	27-30
19592671-3	2009	Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin-mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene.	Dioxins	88-94	epidermal growth factor	Homo sapiens	69-72
19592671-3	2009	Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin-mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene.	Dioxins	88-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
19592671-3	2009	Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin-mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene.	Dioxins	88-94	E1A binding protein p300	Homo sapiens	236-240
19592671-3	2009	Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin-mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene.	Dioxins	88-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	248-254
19592671-4	2009	EGF also inhibits the dioxin-dependent induction of certain parameters in keratinocytes that are reflective of dioxin-induced chloracne.	Dioxins	22-28	epidermal growth factor	Homo sapiens	0-3
19592671-4	2009	EGF also inhibits the dioxin-dependent induction of certain parameters in keratinocytes that are reflective of dioxin-induced chloracne.	Dioxins	111-117	epidermal growth factor	Homo sapiens	0-3
19592671-5	2009	These findings point to the potential usefulness of EGF for the treatment of chloracne and also describe a novel mechanism for repression of dioxin-induced gene transcription.	Dioxins	141-147	epidermal growth factor	Homo sapiens	52-55
19588848-1	2009	PCB and dioxin-like PCB (DL-PCB) in 28 umbilical cords preserved from the time when 3 Yusho victims and 11 healthy subjects gave birth were examined in order to investigate the pollution evaluation with both the compounds in Yusho victims on the basis of the analytical value.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
19268519-6	2009	A transient transfection assay using a dioxin response element (DRE)-linked luciferase reporter and an electrophoretic mobility shift assay revealed that AA reduced the amount of AhR that could form a complex with the DRE sequence in the promoter region of the CYP1A1 gene.	Dioxins	39-45	aryl hydrocarbon receptor	Homo sapiens	179-182
19428948-1	2009	The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.	Dioxins	147-154	aryl-hydrocarbon receptor	Mus musculus	4-29
19428948-1	2009	The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.	Dioxins	147-154	aryl-hydrocarbon receptor	Mus musculus	31-34
19588848-1	2009	PCB and dioxin-like PCB (DL-PCB) in 28 umbilical cords preserved from the time when 3 Yusho victims and 11 healthy subjects gave birth were examined in order to investigate the pollution evaluation with both the compounds in Yusho victims on the basis of the analytical value.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
19286049-1	2009	Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	108-115	aryl hydrocarbon receptor	Homo sapiens	0-25
19058852-0	2009	Dioxin and dioxin-like PCB profiles in the serum of industrial and municipal waste incinerator workers in Korea.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
19557242-0	2009	Estimation and characterization of PCDD/Fs and dioxin-like PCB emission from secondary zinc and lead metallurgies in China.	Dioxins	47-53	Pyruvate carboxylase	Drosophila melanogaster	59-62
19287966-1	2009	Cytochrome P450 (CYP) 1A1 (CYP1A1) and CYP1B1, dioxin-inducible CYP1s, are associated with carcinogenesis in extrahepatic tissues.	Dioxins	47-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-25
19287966-1	2009	Cytochrome P450 (CYP) 1A1 (CYP1A1) and CYP1B1, dioxin-inducible CYP1s, are associated with carcinogenesis in extrahepatic tissues.	Dioxins	47-53	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45
19167471-1	2009	This study investigates the dose-dependent expression of CYP1A1 and CYP1B1 in primary cultured bovine hepatocytes exposed to TCDD, several polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) congeners and fish oil used as animal feed ingredients to identify their dioxin-like potentials.	Dioxins	164-170	cytochrome P450 1A1	Bos taurus	57-63
19167471-1	2009	This study investigates the dose-dependent expression of CYP1A1 and CYP1B1 in primary cultured bovine hepatocytes exposed to TCDD, several polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) congeners and fish oil used as animal feed ingredients to identify their dioxin-like potentials.	Dioxins	164-170	cytochrome P450 1B1	Bos taurus	68-74
19261855-0	2009	The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.	Dioxins	16-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	62-68
19261855-0	2009	The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.	Dioxins	16-22	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	73-79
19261855-0	2009	The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.	Dioxins	16-22	aryl-hydrocarbon receptor	Mus musculus	88-113
19261855-1	2009	The aryl hydrocarbon receptor (AHR) plays a central role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development.	Dioxins	89-95	aryl-hydrocarbon receptor	Mus musculus	4-29
19261855-1	2009	The aryl hydrocarbon receptor (AHR) plays a central role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development.	Dioxins	89-95	aryl-hydrocarbon receptor	Mus musculus	31-34
19261855-2	2009	Each of these processes appears to be dependent on binding of the AHR to dioxin- responsive elements (DREs) within the genome.	Dioxins	73-79	aryl-hydrocarbon receptor	Mus musculus	66-69
19158084-1	2009	The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	250-256	aryl hydrocarbon receptor	Homo sapiens	4-29
19158084-1	2009	The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	250-256	aryl hydrocarbon receptor	Homo sapiens	31-34
19286049-1	2009	Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs).	Dioxins	108-115	aryl hydrocarbon receptor	Homo sapiens	27-30
19047483-8	2009	After dioxin or beta-naphthoflavone treatment of these mouse lines, the CYP1A1 protein was shown to be located in the mitochondria of the Cyp1a1(mtp/mtp) and Cyp1a1(mtt/mtt) lines and in microsomes of the Cyp1a1(mc/mc) line.	Dioxins	6-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-78
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	70-95
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	97-100
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	144-176
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	178-182
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	243-249
19255421-3	2009	Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1.	Dioxins	23-29	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	254-260
19255421-5	2009	We show that this acceleration is mediated by the AHR; also, that dioxin increases the expression of several genes known to be regulated by ARNT, which have critical roles in the cornification and epidermal barrier function of the skin.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	50-53
19255421-5	2009	We show that this acceleration is mediated by the AHR; also, that dioxin increases the expression of several genes known to be regulated by ARNT, which have critical roles in the cornification and epidermal barrier function of the skin.	Dioxins	66-72	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	140-144
19368229-3	2009	The potencies of 19 individual ClPAHs and 11 individual BrPAHs to induce aryl hydrocarbon receptor (AhR)-mediated activities (i.e., dioxin-like toxicity), relative to the potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were determined in vitro by use of a recombinant rat hepatoma cell (H4IIE-luc) assay.	Dioxins	132-138	aryl hydrocarbon receptor	Rattus norvegicus	73-98
19368229-3	2009	The potencies of 19 individual ClPAHs and 11 individual BrPAHs to induce aryl hydrocarbon receptor (AhR)-mediated activities (i.e., dioxin-like toxicity), relative to the potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were determined in vitro by use of a recombinant rat hepatoma cell (H4IIE-luc) assay.	Dioxins	132-138	aryl hydrocarbon receptor	Rattus norvegicus	100-103
19269596-2	2009	Environmental contaminants, dioxins, develop various adverse effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	28-35	aryl hydrocarbon receptor	Homo sapiens	107-132
19269596-2	2009	Environmental contaminants, dioxins, develop various adverse effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	28-35	aryl hydrocarbon receptor	Homo sapiens	134-137
19047483-8	2009	After dioxin or beta-naphthoflavone treatment of these mouse lines, the CYP1A1 protein was shown to be located in the mitochondria of the Cyp1a1(mtp/mtp) and Cyp1a1(mtt/mtt) lines and in microsomes of the Cyp1a1(mc/mc) line.	Dioxins	6-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	138-144
18838062-1	2009	The arylhydrocarbon receptor (AhR) mediates the adverse effects of dioxins, including modulation of sex steroid hormone signaling.	Dioxins	67-74	aryl hydrocarbon receptor	Homo sapiens	4-28
18838062-1	2009	The arylhydrocarbon receptor (AhR) mediates the adverse effects of dioxins, including modulation of sex steroid hormone signaling.	Dioxins	67-74	aryl hydrocarbon receptor	Homo sapiens	30-33
18955032-3	2009	The AhR/RelB dimer is capable of binding to DNA response elements including the dioxin response element (DRE) as well as NF-kappaB binding sites supporting the activation of target genes of the AhR as well as NF-kappaB pathway.	Dioxins	80-86	aryl hydrocarbon receptor	Homo sapiens	4-7
18955032-3	2009	The AhR/RelB dimer is capable of binding to DNA response elements including the dioxin response element (DRE) as well as NF-kappaB binding sites supporting the activation of target genes of the AhR as well as NF-kappaB pathway.	Dioxins	80-86	RELB proto-oncogene, NF-kB subunit	Homo sapiens	8-12
18955032-3	2009	The AhR/RelB dimer is capable of binding to DNA response elements including the dioxin response element (DRE) as well as NF-kappaB binding sites supporting the activation of target genes of the AhR as well as NF-kappaB pathway.	Dioxins	80-86	aryl hydrocarbon receptor	Homo sapiens	194-197
18983984-4	2009	For decades the AhR has been studied mainly for its toxic effects after artificial activation by man-made chemical pollutants such as dioxins.	Dioxins	134-141	aryl hydrocarbon receptor	Homo sapiens	16-19
18996358-1	2009	Evidence has been accumulating to indicate that the current classical model of dioxin"s action based on the ligand-activated aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) dimer directly activating its target genes is not robust enough to explain many of the major toxic effects of this compound.	Dioxins	79-85	aryl hydrocarbon receptor	Homo sapiens	125-150
18996358-1	2009	Evidence has been accumulating to indicate that the current classical model of dioxin"s action based on the ligand-activated aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) dimer directly activating its target genes is not robust enough to explain many of the major toxic effects of this compound.	Dioxins	79-85	aryl hydrocarbon receptor	Homo sapiens	152-155
18996358-1	2009	Evidence has been accumulating to indicate that the current classical model of dioxin"s action based on the ligand-activated aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) dimer directly activating its target genes is not robust enough to explain many of the major toxic effects of this compound.	Dioxins	79-85	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	161-185
18996358-1	2009	Evidence has been accumulating to indicate that the current classical model of dioxin"s action based on the ligand-activated aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) dimer directly activating its target genes is not robust enough to explain many of the major toxic effects of this compound.	Dioxins	79-85	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	187-191
18996358-2	2009	In this review, efforts have been made to analyze the results of recent investigations in our laboratory in comparison to already existing evidence on the patterns of toxic actions of dioxin (=TCDD) from other laboratories from a specific viewpoint of elicitation of cellular inflammatory signaling by the ligand-activated AHR.	Dioxins	184-190	aryl hydrocarbon receptor	Homo sapiens	323-326
18996358-7	2009	Together, the evidence strongly support the notion that the inflammatory action of the ligand-activated AHR that is mediated by the nongenomic pathway plays the major role in the inflammation inducing actions of dioxin-like chemicals.	Dioxins	212-218	aryl hydrocarbon receptor	Homo sapiens	104-107
19013136-3	2009	The environmental toxin dioxin binds with high affinity to AHR rendering it nuclear and leading to the activation of AHR sensitive genes.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	59-62
19013136-3	2009	The environmental toxin dioxin binds with high affinity to AHR rendering it nuclear and leading to the activation of AHR sensitive genes.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	117-120
19026991-0	2009	Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster.	Dioxins	68-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-41
19026991-0	2009	Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster.	Dioxins	68-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-52
19041680-2	2009	Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do.	Dioxins	11-18	aryl-hydrocarbon receptor	Mus musculus	75-100
19041680-2	2009	Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do.	Dioxins	11-18	aryl-hydrocarbon receptor	Mus musculus	102-105
18583386-0	2008	Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls.	Dioxins	114-120	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	53-72
19270430-1	2009	Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor.	Dioxins	44-51	aryl hydrocarbon receptor	Homo sapiens	109-134
19270430-1	2009	Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor.	Dioxins	44-51	aryl hydrocarbon receptor	Homo sapiens	136-139
18842620-0	2009	Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells.	Dioxins	33-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
18842620-0	2009	Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells.	Dioxins	33-39	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	64-70
18842620-1	2009	Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7.	Dioxins	83-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-25
18842620-1	2009	Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7.	Dioxins	83-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	30-36
18842620-3	2009	Dioxin treatment leads to recruitment of the aryl hydrocarbon receptor to the enhancer regions but not to the proximal promoter regions of both the CYP1A1 and CYP1B1 genes.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	45-70
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	nuclear receptor coactivator 1	Homo sapiens	80-110
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	nuclear receptor coactivator 1	Homo sapiens	112-117
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	nuclear receptor coactivator 2	Homo sapiens	155-160
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	E1A binding protein p300	Homo sapiens	166-170
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	256-262
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	264-267
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	294-299
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	378-384
18842620-5	2009	Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1.	Dioxins	0-6	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	397-403
18842620-6	2009	Small inhibitory RNA-mediated knockdown of p300 and SRC-2 adversely affected dioxin induction of both genes, whereas knockdown of BRM/BRG-1 reduced CYP1A1 induction but had little, if any, effect on CYP1B1 induction.	Dioxins	77-83	E1A binding protein p300	Homo sapiens	43-47
18842620-6	2009	Small inhibitory RNA-mediated knockdown of p300 and SRC-2 adversely affected dioxin induction of both genes, whereas knockdown of BRM/BRG-1 reduced CYP1A1 induction but had little, if any, effect on CYP1B1 induction.	Dioxins	77-83	nuclear receptor coactivator 2	Homo sapiens	52-57
18842620-7	2009	These results suggest that nucleosomal remodeling is less significant for dioxin-mediated induction of CYP1B1 than that of CYP1A1 and may be related to the more modest inducibility of the former.	Dioxins	74-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-109
18842620-7	2009	These results suggest that nucleosomal remodeling is less significant for dioxin-mediated induction of CYP1B1 than that of CYP1A1 and may be related to the more modest inducibility of the former.	Dioxins	74-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
18842620-9	2009	These observations provide novel insights into the functional roles of the endogenous coactivators in dioxin induction of the human CYP1A1 and CYP1B1 genes in their natural chromosomal configurations.	Dioxins	102-108	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
18842620-9	2009	These observations provide novel insights into the functional roles of the endogenous coactivators in dioxin induction of the human CYP1A1 and CYP1B1 genes in their natural chromosomal configurations.	Dioxins	102-108	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	143-149
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Dioxins	70-76	aryl hydrocarbon receptor	Homo sapiens	35-38
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Dioxins	70-76	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	39-43
18835618-2	2008	In this study, we have developed a highly sensitive AhR-mediated reporter cell line, DR-EcoScreen cells, which are mouse hepatoma Hepa1c1c7 cells stably transfected with a reporter plasmid containing seven copies of dioxin-responsive element.	Dioxins	216-222	aryl-hydrocarbon receptor	Mus musculus	52-55
19282623-2	2008	It has been shown that the binding of AhR to DNA depends on the dioxin response element (DRE) and controls xenobiotic-response genes.	Dioxins	64-70	aryl-hydrocarbon receptor	Mus musculus	38-41
17869316-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological actions of many aromatic environmental pollutants such as dioxins.	Dioxins	176-183	aryl hydrocarbon receptor	Homo sapiens	4-29
17869316-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological actions of many aromatic environmental pollutants such as dioxins.	Dioxins	176-183	aryl hydrocarbon receptor	Homo sapiens	31-34
17869316-2	2008	We investigated AhR activation by some vegetable constituents, including flavonoids, tannins, and related polyphenols, using an AhR-based in vitro bioassay for dioxins.	Dioxins	160-167	aryl hydrocarbon receptor	Homo sapiens	16-19
17869316-4	2008	On the other hand, some flavones such as apigenin, flavonols such as quercetin, and anthraquinones such as emodin, showed notable inhibitory effects on the in vitro activation of AhR induced by the dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)].	Dioxins	198-204	aryl hydrocarbon receptor	Homo sapiens	179-182
19257943-0	2008	[Regulation of dioxin on gene expression of insulin-like growth factor II in rat osteoblasts].	Dioxins	15-21	insulin-like growth factor 2	Rattus norvegicus	44-73
18928297-1	2008	Dioxins enter the body through the diet and cause various toxicological effects through transformation of an aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	109-134
18928297-1	2008	Dioxins enter the body through the diet and cause various toxicological effects through transformation of an aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	136-139
18465118-1	2008	Dioxins exert their major toxicologic effects by binding to the aryl hydrocarbon receptor (AHR) and altering gene transcription.	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	64-89
18465118-1	2008	Dioxins exert their major toxicologic effects by binding to the aryl hydrocarbon receptor (AHR) and altering gene transcription.	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	91-94
18465118-5	2008	The three dioxin-resistant strains/lines all harbor a large deletion in the transactivation domain of the aryl hydrocarbon receptor (AHR).	Dioxins	10-16	aryl hydrocarbon receptor	Rattus norvegicus	106-131
18465118-5	2008	The three dioxin-resistant strains/lines all harbor a large deletion in the transactivation domain of the aryl hydrocarbon receptor (AHR).	Dioxins	10-16	aryl hydrocarbon receptor	Rattus norvegicus	133-136
18465118-7	2008	Several genes that previously were well established as being dioxin-responsive or under AHR regulation emerged as Type-I responses (e.g. CYP1A1, CYP1A2, CYP1B1 and Gsta3).	Dioxins	61-67	aryl hydrocarbon receptor	Rattus norvegicus	88-91
18465118-7	2008	Several genes that previously were well established as being dioxin-responsive or under AHR regulation emerged as Type-I responses (e.g. CYP1A1, CYP1A2, CYP1B1 and Gsta3).	Dioxins	61-67	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	137-143
18465118-7	2008	Several genes that previously were well established as being dioxin-responsive or under AHR regulation emerged as Type-I responses (e.g. CYP1A1, CYP1A2, CYP1B1 and Gsta3).	Dioxins	61-67	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	145-151
18465118-7	2008	Several genes that previously were well established as being dioxin-responsive or under AHR regulation emerged as Type-I responses (e.g. CYP1A1, CYP1A2, CYP1B1 and Gsta3).	Dioxins	61-67	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	153-159
18465118-7	2008	Several genes that previously were well established as being dioxin-responsive or under AHR regulation emerged as Type-I responses (e.g. CYP1A1, CYP1A2, CYP1B1 and Gsta3).	Dioxins	61-67	glutathione S-transferase alpha 3	Rattus norvegicus	164-169
18950284-1	2008	BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation.	Dioxins	56-63	aryl hydrocarbon receptor	Homo sapiens	135-160
18950284-1	2008	BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation.	Dioxins	56-63	aryl hydrocarbon receptor	Homo sapiens	162-165
19158084-5	2009	Trichostatin A and suberoylanilide hydroxamic acid, two broad spectrum HDAC inhibitors, blocked PAH and dioxin-mediated induction of CYP1A1 and CYP1B1 in cell lines derived from the human aerodigestive tract.	Dioxins	104-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
19158084-5	2009	Trichostatin A and suberoylanilide hydroxamic acid, two broad spectrum HDAC inhibitors, blocked PAH and dioxin-mediated induction of CYP1A1 and CYP1B1 in cell lines derived from the human aerodigestive tract.	Dioxins	104-110	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	144-150
19038280-0	2009	Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver.	Dioxins	69-75	aryl-hydrocarbon receptor	Mus musculus	83-86
19041884-0	2009	Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds.	Dioxins	135-141	Cytochrome P450 1A1	Canis lupus familiaris	70-76
19041884-0	2009	Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds.	Dioxins	135-141	cytochrome P450 family 1 subfamily A member 2	Canis lupus familiaris	81-87
19691822-1	2009	The aryl hydrocarbon receptor is a ligand-activated transcriptional regulator that binds dioxin and other exogenous contaminants and is responsible for their toxic effects, including immunosuppression.	Dioxins	89-95	aryl hydrocarbon receptor	Homo sapiens	4-29
18948129-0	2009	Dioxin activation of CYP1A5 promoter/enhancer regions from two avian species, common cormorant (Phalacrocorax carbo) and chicken (Gallus gallus): association with aryl hydrocarbon receptor 1 and 2 isoforms.	Dioxins	0-6	cytochrome P450 1A5-like	Phalacrocorax carbo	21-27
18948129-0	2009	Dioxin activation of CYP1A5 promoter/enhancer regions from two avian species, common cormorant (Phalacrocorax carbo) and chicken (Gallus gallus): association with aryl hydrocarbon receptor 1 and 2 isoforms.	Dioxins	0-6	aryl hydrocarbon receptor 2	Gallus gallus	163-196
18948129-8	2009	Therefore, the structural difference in AHR, not the CYP1A5 regulatory region may be a major factor to account for the dioxin susceptibility in avian species.	Dioxins	119-125	aryl hydrocarbon receptor 1 alpha	Gallus gallus	40-43
18787049-0	2008	Aryl hydrocarbon receptor-interacting protein and pituitary adenomas: a population-based study on subjects exposed to dioxin after the Seveso, Italy, accident.	Dioxins	118-124	aryl hydrocarbon receptor interacting protein	Homo sapiens	0-45
18787049-3	2008	AIP is a chaperone protein with multifunction properties, including modulation of the transcriptional activity of the aryl hydrocarbon receptor, which mediates toxicological and carcinogenic dioxin effects.	Dioxins	191-197	aryl hydrocarbon receptor interacting protein	Homo sapiens	0-3
18787049-3	2008	AIP is a chaperone protein with multifunction properties, including modulation of the transcriptional activity of the aryl hydrocarbon receptor, which mediates toxicological and carcinogenic dioxin effects.	Dioxins	191-197	aryl hydrocarbon receptor	Homo sapiens	118-143
18930947-0	2008	Ah receptor binding to its cognate response element is required for dioxin-mediated toxicity.	Dioxins	68-74	aryl hydrocarbon receptor	Homo sapiens	0-11
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	15-21
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	26-32
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	137-143
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	aryl-hydrocarbon receptor	Mus musculus	153-156
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	125-130
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	214-220
18814841-3	2008	By quantifying CYP1A1 and CYP1A2 mRNA in liver, lung and kidney of dioxin-treated mice, we show that dose-response curves in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mice are shifted to the right of those in hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(b1) mice-similar to, but not as robust as, dose-response curves in DBA/2J versus C57BL/6J mice.	Dioxins	67-73	aryl-hydrocarbon receptor	Mus musculus	230-233
18704375-6	2008	The consequences are very different from those of AHR nuclear translocation mediated by its classic ligands (such as dioxin and many polycyclic aromatic hydrocarbons) and may represent the long-sought physiological function of the AHR.	Dioxins	117-123	aryl hydrocarbon receptor	Homo sapiens	50-53
18704375-6	2008	The consequences are very different from those of AHR nuclear translocation mediated by its classic ligands (such as dioxin and many polycyclic aromatic hydrocarbons) and may represent the long-sought physiological function of the AHR.	Dioxins	117-123	aryl hydrocarbon receptor	Homo sapiens	231-234
18704375-7	2008	The disturbance of this physiological function of AHR by extremely persistent high-affinity xenobiotic ligands such as dioxin may represent the most important contributing factor for their potent toxicity.	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	50-53
18583386-3	2008	Dioxin-like PCBs have been shown to tightly bind the active site of cytochrome P450 (CYP) 1A isoforms, primarily CYP1A1, resulting in inhibition of CYP activity and the generation of reactive oxygen species (ROS) as a result of uncoupling of the catalytic cycle.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
18583386-6	2008	It has been demonstrated previously that hCYP1B1 is inhibited by dioxin-like PCBs, but whether or not it is uncoupled has not been investigated.	Dioxins	65-71	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	41-48
18583386-7	2008	In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated.	Dioxins	43-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	181-188
18583386-7	2008	In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated.	Dioxins	43-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	279-286
18849443-3	2008	Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	17-41
18259752-5	2008	We found that xenobiotics that positively and negatively affect AhR"s activity as a transcription factor (e.g., dioxin and alpha-naphthoflavone, respectively), have similar effects on AhR"s ability to affect AD1-domain-dependent transcription.	Dioxins	112-118	aryl hydrocarbon receptor	Homo sapiens	64-67
18259752-5	2008	We found that xenobiotics that positively and negatively affect AhR"s activity as a transcription factor (e.g., dioxin and alpha-naphthoflavone, respectively), have similar effects on AhR"s ability to affect AD1-domain-dependent transcription.	Dioxins	112-118	aryl hydrocarbon receptor	Homo sapiens	184-187
18259752-5	2008	We found that xenobiotics that positively and negatively affect AhR"s activity as a transcription factor (e.g., dioxin and alpha-naphthoflavone, respectively), have similar effects on AhR"s ability to affect AD1-domain-dependent transcription.	Dioxins	112-118	amyloid beta precursor protein	Homo sapiens	208-211
18849443-3	2008	Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	43-46
18849443-3	2008	Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1.	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-92
18849443-3	2008	Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1.	Dioxins	0-7	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	97-103
18849443-12	2008	These results suggest an up-regulation of dioxin-inducible CYP1A1 and gamma-SYN occurs in endometriosis.	Dioxins	42-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
18849443-12	2008	These results suggest an up-regulation of dioxin-inducible CYP1A1 and gamma-SYN occurs in endometriosis.	Dioxins	42-48	synuclein gamma	Homo sapiens	70-79
18660548-2	2008	The classical AHR pathway involves ligand binding, nuclear translocation, heterodimerization with the AHR nuclear translocator (ARNT), and binding of the heterodimer to dioxin response elements (DREs), thereby modulating the transcription of an array of genes.	Dioxins	169-175	aryl-hydrocarbon receptor	Mus musculus	14-17
18649880-6	2008	Simple and partial correlation analyses revealed that HbA1c correlated with the accumulated TEQs of PCDDs+PCDFs, dioxin-like PCBs and total dioxins.	Dioxins	113-119	hemoglobin subunit alpha 1	Homo sapiens	54-58
18762178-1	2008	Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs.	Dioxins	145-152	aryl hydrocarbon receptor	Homo sapiens	30-55
18762178-1	2008	Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs.	Dioxins	145-152	aryl hydrocarbon receptor	Homo sapiens	57-60
18762178-1	2008	Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs.	Dioxins	145-151	aryl hydrocarbon receptor	Homo sapiens	30-55
18762178-1	2008	Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs.	Dioxins	145-151	aryl hydrocarbon receptor	Homo sapiens	57-60
18691609-3	2008	The AhR induces cell-specific changes in gene transcription via binding to the dioxin response element DRE; however, the underlying specificity-mechanisms, in particular with regard to the role of promoter element context, and possible transcription factor crosstalk remain poorly understood.	Dioxins	79-85	aryl hydrocarbon receptor	Homo sapiens	4-7
18718631-4	2008	Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the blood of pregnant women.	Dioxins	18-24	pyruvate carboxylase	Homo sapiens	30-33
18718631-5	2008	The arithmetic mean total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers in Sapporo City were 42.2-329.3 (mean: 114.5, median: 98.6) and 31.5-258.0 (mean: 100.3, median: 91.4)ngg(-1)lipid, respectively.	Dioxins	51-57	pyruvate carboxylase	Homo sapiens	63-66
18718631-11	2008	Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
18718631-11	2008	Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	207-210
18718631-11	2008	Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers.	Dioxins	195-201	pyruvate carboxylase	Homo sapiens	26-29
18718631-12	2008	With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly increased with increasing maternal age in both groups.	Dioxins	75-81	pyruvate carboxylase	Homo sapiens	87-90
18718631-12	2008	With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly increased with increasing maternal age in both groups.	Dioxins	75-81	pyruvate carboxylase	Homo sapiens	226-229
18768207-4	2008	Among 197 non-dioxin-like PCB congeners, 56 were identified in the blood of elderly residents.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
18342938-0	2008	Converting Toxic Equivalents (TEQ) of dioxins and dioxin-like compounds in fish from one Toxic Equivalency Factor (TEF) scheme to another.	Dioxins	38-45	TEF transcription factor, PAR bZIP family member	Homo sapiens	115-118
18342938-0	2008	Converting Toxic Equivalents (TEQ) of dioxins and dioxin-like compounds in fish from one Toxic Equivalency Factor (TEF) scheme to another.	Dioxins	38-44	TEF transcription factor, PAR bZIP family member	Homo sapiens	115-118
18936997-22	2008	The activity of persistent dioxin-like acting compounds in multilayer and carbon fractionated PCDD/F and PCB fractions was low if compared to corresponding crude extracts.	Dioxins	27-33	pyruvate carboxylase	Bos taurus	105-108
18939598-0	2008	Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species.	Dioxins	57-63	aryl hydrocarbon receptor 1 alpha	Gallus gallus	23-48
18708059-1	2008	Cyclophilin-40 (CyP40) promotes the formation of the gel shift complex that contains the aryl hydrocarbon receptor (AhR), AhR nuclear translocator (Arnt) and dioxin response element (DRE) using baculovirus expressed proteins.	Dioxins	158-164	peptidylprolyl isomerase D	Homo sapiens	0-14
18708059-1	2008	Cyclophilin-40 (CyP40) promotes the formation of the gel shift complex that contains the aryl hydrocarbon receptor (AhR), AhR nuclear translocator (Arnt) and dioxin response element (DRE) using baculovirus expressed proteins.	Dioxins	158-164	peptidylprolyl isomerase D	Homo sapiens	16-21
18640100-0	2008	Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	57-82
18640100-4	2008	Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone.	Dioxins	19-25	aryl hydrocarbon receptor	Homo sapiens	200-225
18640100-4	2008	Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone.	Dioxins	19-25	aryl hydrocarbon receptor	Homo sapiens	227-230
18606429-0	2008	Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin.	Dioxins	121-127	prostaglandin-endoperoxide synthase 2	Mus musculus	17-33
18795168-5	2008	OBJECTIVES: We aimed to identify the functional TR domain responsible for the PCB-mediated suppression of TR action by comparing the magnitude of suppression using several representative PCB/dioxin congeners.	Dioxins	191-197	pyruvate carboxylase	Homo sapiens	78-81
18649880-6	2008	Simple and partial correlation analyses revealed that HbA1c correlated with the accumulated TEQs of PCDDs+PCDFs, dioxin-like PCBs and total dioxins.	Dioxins	140-147	hemoglobin subunit alpha 1	Homo sapiens	54-58
18495758-1	2008	Exposure to dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes a wide array of toxicities in vertebrates, which are mostly considered to be mediated through the inappropriate activation of the aryl hydrocarbon receptor (AHR) signaling pathway.	Dioxins	12-19	aryl hydrocarbon receptor 1a	Danio rerio	212-237
18583386-10	2008	These data identify a novel mechanism of genotoxicity for dioxin-like PCBs, as well as providing further evidence that overexpression of hCYP1B1 is a risk factor for extrahepatic carcinogenesis.	Dioxins	58-64	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	137-144
18767702-5	2008	Total concentrations of dioxin-like PCBtoxic equivalents (TEQs), measured as the aryl hydrocarbon receptor (AhR)-mediated responses of the H4IIE-luc bioassay (TEQH4IIE-luc), were greatest in Hong Kong samples.	Dioxins	24-30	aryl hydrocarbon receptor	Egretta garzetta	81-106
18767702-5	2008	Total concentrations of dioxin-like PCBtoxic equivalents (TEQs), measured as the aryl hydrocarbon receptor (AhR)-mediated responses of the H4IIE-luc bioassay (TEQH4IIE-luc), were greatest in Hong Kong samples.	Dioxins	24-30	aryl hydrocarbon receptor	Egretta garzetta	108-111
18495758-1	2008	Exposure to dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes a wide array of toxicities in vertebrates, which are mostly considered to be mediated through the inappropriate activation of the aryl hydrocarbon receptor (AHR) signaling pathway.	Dioxins	12-19	aryl hydrocarbon receptor 1a	Danio rerio	239-242
18166985-4	2008	Adipose tissue samples were analyzed for PCDD/F and 12 dioxin-like PCB congeners using high-resolution gas chromatography/high-resolution mass spectrometry.	Dioxins	55-61	pyruvate carboxylase	Homo sapiens	67-70
18433817-6	2008	UGT1A4 transcription was dioxin inducible.	Dioxins	25-31	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	0-6
18166985-7	2008	Concentrations of each of the PCDD/F and dioxin-like PCB congeners were compared in fertile and infertile groups among themselves, and no statistical significance was obtained (p > 0.05), except 2,3,7,8-tetrachlorodibenzofuran (p = 0.0029) and 1,2,3,4,6,7,8,9-octachlorodibenzofuran (p = 0.01).	Dioxins	41-47	pyruvate carboxylase	Homo sapiens	53-56
18313043-9	2008	Serum TSH increased with hair and blood Hg concentrations and was highest among those in the highest 50th percentile for both Hg and dioxin-like PCB congeners compared to the others.	Dioxins	133-139	pyruvate carboxylase	Homo sapiens	145-148
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	200-206	aryl hydrocarbon receptor	Homo sapiens	159-162
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	200-206	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	193-199
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	63-70	aryl hydrocarbon receptor	Homo sapiens	159-162
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	200-206	aryl hydrocarbon receptor	Homo sapiens	274-277
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	63-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	193-199
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	159-162
18385208-0	2008	An aryl hydrocarbon receptor repressor from Xenopus laevis: function, expression, and role in dioxin responsiveness during frog development.	Dioxins	94-100	aryl-hydrocarbon receptor repressor L homeolog	Xenopus laevis	3-38
17912254-4	2008	These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis.	Dioxins	63-69	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	193-199
18063300-3	2008	The dioxin in the sediment samples was found to come from a mixture of the impurities of pentachlorophenol (PCP), chloronitrofen (CNP) and combustion based on the result of hierarchical cluster analysis (HCA).	Dioxins	4-10	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	130-133
18440119-7	2008	Deletion analysis localized the paradoxical induction response to a region between -1.8 kb and -1.3 kb, which contains a dioxin-responsive element (DRE) previously shown by us to be capable of binding activated AHR.	Dioxins	121-127	aryl hydrocarbon receptor	Homo sapiens	211-214
18358233-0	2008	Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings.	Dioxins	47-54	aryl hydrocarbon receptor	Homo sapiens	10-13
18358233-1	2008	The arylhydrocarbon receptor (AhR) mediates sex steroid hormone-related actions in both normal physiology and in dioxin toxicity.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	4-28
18358233-1	2008	The arylhydrocarbon receptor (AhR) mediates sex steroid hormone-related actions in both normal physiology and in dioxin toxicity.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	30-33
18295293-0	2008	Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver.	Dioxins	9-16	aryl-hydrocarbon receptor	Mus musculus	124-149
18313660-0	2008	Relationship between insulin sensitivity and exposure to dioxins and polychlorinated biphenyls in pregnant women.	Dioxins	57-64	insulin	Homo sapiens	21-28
18484306-1	2008	The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls.	Dioxins	92-99	aryl hydrocarbon receptor	Homo sapiens	4-29
18484306-1	2008	The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls.	Dioxins	92-99	aryl hydrocarbon receptor	Homo sapiens	31-34
18484306-1	2008	The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls.	Dioxins	92-98	aryl hydrocarbon receptor	Homo sapiens	4-29
18484306-1	2008	The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls.	Dioxins	92-98	aryl hydrocarbon receptor	Homo sapiens	31-34
18367304-4	2008	We found that both 2,2",4,4"-tetrachlorobiphenyl (PCB 47) and 2,2",4,4",5,5"-hexachlorobiphenyl (PCB 153), but not the dioxin-like, non-ortho-substituted, 3,3",4,4",5-pentachlorobiphenyl (PCB 126), induce a massive release of AA.	Dioxins	119-125	pyruvate carboxylase	Rattus norvegicus	50-53
18329192-0	2008	Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne.	Dioxins	75-81	aryl hydrocarbon receptor	Homo sapiens	14-17
18294953-1	2008	The aryl hydrocarbon receptor (AhR) mediates the toxicity of dioxins and related xenobiotics.	Dioxins	61-68	aryl-hydrocarbon receptor	Mus musculus	4-29
18294953-1	2008	The aryl hydrocarbon receptor (AhR) mediates the toxicity of dioxins and related xenobiotics.	Dioxins	61-68	aryl-hydrocarbon receptor	Mus musculus	31-34
18045642-8	2008	Twelve dioxin-like PCBs contributed around 8% of the total PCB exposure, and all were present in all study subjects.	Dioxins	7-13	pyruvate carboxylase	Homo sapiens	19-22
18329192-0	2008	Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne.	Dioxins	75-81	transforming growth factor alpha	Homo sapiens	44-53
18329192-3	2008	It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha.	Dioxins	20-27	aryl hydrocarbon receptor	Homo sapiens	81-106
18329192-3	2008	It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha.	Dioxins	20-27	aryl hydrocarbon receptor	Homo sapiens	108-111
18329192-3	2008	It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha.	Dioxins	20-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	165-171
18329192-3	2008	It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha.	Dioxins	20-27	glutathione S-transferase alpha 1	Homo sapiens	173-178
18329192-3	2008	It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha.	Dioxins	20-27	transforming growth factor alpha	Homo sapiens	183-192
18329192-6	2008	Compared with controls, AhR, CYP1A1, GSTA1 and c-fos transactivations were significantly induced in the skins of chloracne patients who had long-term exposure to dioxins and dibenzofuranes.	Dioxins	162-169	aryl hydrocarbon receptor	Homo sapiens	24-27
18329192-6	2008	Compared with controls, AhR, CYP1A1, GSTA1 and c-fos transactivations were significantly induced in the skins of chloracne patients who had long-term exposure to dioxins and dibenzofuranes.	Dioxins	162-169	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
18329192-6	2008	Compared with controls, AhR, CYP1A1, GSTA1 and c-fos transactivations were significantly induced in the skins of chloracne patients who had long-term exposure to dioxins and dibenzofuranes.	Dioxins	162-169	glutathione S-transferase alpha 1	Homo sapiens	37-42
18329192-6	2008	Compared with controls, AhR, CYP1A1, GSTA1 and c-fos transactivations were significantly induced in the skins of chloracne patients who had long-term exposure to dioxins and dibenzofuranes.	Dioxins	162-169	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-52
17991765-0	2008	The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.	Dioxins	213-219	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	25-71
18178667-1	2008	Activation of the aryl hydrocarbon receptor (AHR) by agonists and environmental contaminants like dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) leads to many adverse biological effects, including tumor promotion.	Dioxins	98-104	aryl hydrocarbon receptor	Homo sapiens	18-43
18178667-1	2008	Activation of the aryl hydrocarbon receptor (AHR) by agonists and environmental contaminants like dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) leads to many adverse biological effects, including tumor promotion.	Dioxins	98-104	aryl hydrocarbon receptor	Homo sapiens	45-48
18295415-2	2008	It has some properties that are typical for dioxin-like compounds that act mainly through the aryl hydrocarbon receptor (AhR) protein.	Dioxins	44-50	aryl hydrocarbon receptor	Rattus norvegicus	94-119
18295415-2	2008	It has some properties that are typical for dioxin-like compounds that act mainly through the aryl hydrocarbon receptor (AhR) protein.	Dioxins	44-50	aryl hydrocarbon receptor	Rattus norvegicus	121-124
18295415-3	2008	Upon dioxin binding, the AhR translocates to the nucleus and modulates gene expression.	Dioxins	5-11	aryl hydrocarbon receptor	Rattus norvegicus	25-28
17988715-9	2008	It was suggested that congeners of PCDD, especially highly substituted PCDDs, and PCDFs have a tendency to accumulate in the testis and dioxin-like PCB congeners accumulate readily in adipose tissue.	Dioxins	136-142	pyruvate carboxylase	Bos taurus	148-151
18001814-1	2008	PCDD/F and dioxin-like PCB were measured in 142 air samples of Hong Kong.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
18001814-4	2008	A higher WHO-TEQ value of dioxin-like PCB (mainly attributed to the relatively higher WHO-TEQ value of PCB 126) in Yuen Long during winter, compared with other months, could also be related to the regional transport by the winter monsoon wind and the low mixing height in winter.	Dioxins	26-32	pyruvate carboxylase	Homo sapiens	38-41
18001814-4	2008	A higher WHO-TEQ value of dioxin-like PCB (mainly attributed to the relatively higher WHO-TEQ value of PCB 126) in Yuen Long during winter, compared with other months, could also be related to the regional transport by the winter monsoon wind and the low mixing height in winter.	Dioxins	26-32	pyruvate carboxylase	Homo sapiens	103-106
18001814-5	2008	Spatially, air concentrations of PCDD/F and dioxin-like PCB demonstrated a west-to-east gradient (with Yuen Long>Tsuen Wan>Tap Mun).	Dioxins	44-50	pyruvate carboxylase	Homo sapiens	56-59
18001814-5	2008	Spatially, air concentrations of PCDD/F and dioxin-like PCB demonstrated a west-to-east gradient (with Yuen Long>Tsuen Wan>Tap Mun).	Dioxins	44-50	SEC14 like lipid binding 2	Homo sapiens	129-132
18001814-6	2008	It is suggested that PCDD/F and dioxin-like PCB were transported into the western airshed of Hong Kong from the Pearl River Delta by land-sea breeze circulation and confined to the northwestern part, due to the blocking effect of the northwestern airshed in Hong Kong.	Dioxins	32-38	pyruvate carboxylase	Homo sapiens	44-47
21783853-0	2008	The Belgian PCB/dioxin crisis-8 years later An overview.	Dioxins	16-22	pyruvate carboxylase	Homo sapiens	12-15
21783853-3	2008	This has resulted in a major food crisis, known worldwide as the "Belgian PCB/dioxin crisis".	Dioxins	78-84	pyruvate carboxylase	Homo sapiens	74-77
17973980-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons.	Dioxins	92-98	aryl hydrocarbon receptor	Homo sapiens	4-29
17973980-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons.	Dioxins	92-98	aryl hydrocarbon receptor	Homo sapiens	31-34
17973980-3	2008	In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-responsive gene expression and neurotoxicity.	Dioxins	80-86	aryl hydrocarbon receptor	Homo sapiens	67-70
17973980-4	2008	Our results show that activation of AhR by the selective agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induced dioxin-responsive gene expression and calcium entry, which were attenuated by AhR small interfering RNA, the NMDA receptor channel blocker MK801, and the action potential blocker tetrodotoxin (TTX).	Dioxins	94-100	aryl hydrocarbon receptor	Homo sapiens	36-39
17973980-4	2008	Our results show that activation of AhR by the selective agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induced dioxin-responsive gene expression and calcium entry, which were attenuated by AhR small interfering RNA, the NMDA receptor channel blocker MK801, and the action potential blocker tetrodotoxin (TTX).	Dioxins	94-100	aryl hydrocarbon receptor	Homo sapiens	187-190
17973980-9	2008	Together, the results suggest that neuronal activity may facilitate AhR-mediated calcium signaling, which in turn enhances AhR-mediated gene regulation and mediated maturation-dependent dioxin neurotoxicity.	Dioxins	186-192	aryl hydrocarbon receptor	Homo sapiens	68-71
18055878-3	2008	Analysis of the proximal promoter of the hIGFBP-1 gene reveals the presence of an aryl hydrocarbon binding/dioxin response element (DRE).	Dioxins	107-113	insulin like growth factor binding protein 1	Homo sapiens	41-49
18089838-0	2008	Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	33-58
18089838-0	2008	Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.	Dioxins	0-6	calcium/calmodulin dependent protein kinase I	Homo sapiens	111-121
18294692-0	2008	The common environmental pollutant dioxin-induced memory deficits by altering estrogen pathways and a major route of retinol transport involving transthyretin.	Dioxins	35-41	transthyretin	Mus musculus	145-158
18294692-8	2008	Attenuation of dioxin-induced memory deficits in mice lacking transthyretin (TTR) suggests that TCDD may be acting by affecting the major route of retinol transport involving TTR.	Dioxins	15-21	transthyretin	Mus musculus	62-75
18294692-8	2008	Attenuation of dioxin-induced memory deficits in mice lacking transthyretin (TTR) suggests that TCDD may be acting by affecting the major route of retinol transport involving TTR.	Dioxins	15-21	transthyretin	Mus musculus	77-80
18294692-8	2008	Attenuation of dioxin-induced memory deficits in mice lacking transthyretin (TTR) suggests that TCDD may be acting by affecting the major route of retinol transport involving TTR.	Dioxins	15-21	transthyretin	Mus musculus	175-178
18007012-2	2008	Activation of the aryl hydrocarbon receptor (AhR) by the pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) results in an increased number of neutrophils in the lung after influenza virus infection.	Dioxins	96-102	aryl-hydrocarbon receptor	Mus musculus	45-48
18007012-4	2008	In this study, we determined whether AhR activation increases neutrophil numbers systemically or only in the infected lung, and whether AhR-regulated events within the hematopoietic system underlie the dioxin-induced increase in pulmonary neutrophils observed during influenza virus infection.	Dioxins	202-208	aryl-hydrocarbon receptor	Mus musculus	136-139
18061397-2	2008	Binding to the AhR is widely assumed to activate the main pathway by which dioxins, like 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exert their toxicity.	Dioxins	75-82	aryl hydrocarbon receptor	Homo sapiens	15-18
18155262-4	2008	Firstly, salmon primary hepatocytes were exposed to the dioxin-like PCB126 at 1, 10 and 50 nM [corrected] and ER agonist nonylphenol (NP) at 5 and 10 microM, singly or in combination.	Dioxins	56-62	pyruvate carboxylase	Homo sapiens	68-71
18155262-15	2008	Although not conclusive, our findings represent the first study showing the activation of estrogenic responses by a dioxin-like PCB in fish in vitro system and resemble the "ER-hijacking" hypothesis that was recently proposed.	Dioxins	116-122	pyruvate carboxylase	Homo sapiens	128-131
18072750-4	2008	The AhR is activated by xenobiotica such as dioxins.	Dioxins	44-51	aryl hydrocarbon receptor	Homo sapiens	4-7
18179178-6	2008	Surprisingly, these drugs were shown to have minimal activity toward inducing classical dioxin responsive element-driven AhR-mediated CYP1A1 transcription.	Dioxins	88-94	aryl-hydrocarbon receptor	Mus musculus	121-124
18724896-0	2008	[Effect of dioxin on apoptosis of osteogenic sarcoma cells and regulation on gene expression of insulin-like growth factor binding protein 6].	Dioxins	11-17	insulin like growth factor binding protein 6	Homo sapiens	96-140
17991765-0	2008	The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.	Dioxins	213-219	estrogen receptor 2	Homo sapiens	88-110
17991765-1	2008	The biological effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR) and its dimerization partner, the AhR nuclear translocator (ARNT), and include interference with hormonal signaling pathways like the response to estrogens.	Dioxins	26-33	aryl hydrocarbon receptor	Homo sapiens	54-79
17991765-1	2008	The biological effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR) and its dimerization partner, the AhR nuclear translocator (ARNT), and include interference with hormonal signaling pathways like the response to estrogens.	Dioxins	26-33	aryl hydrocarbon receptor	Homo sapiens	81-84
17991765-1	2008	The biological effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR) and its dimerization partner, the AhR nuclear translocator (ARNT), and include interference with hormonal signaling pathways like the response to estrogens.	Dioxins	26-33	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	120-144
17991765-1	2008	The biological effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR) and its dimerization partner, the AhR nuclear translocator (ARNT), and include interference with hormonal signaling pathways like the response to estrogens.	Dioxins	26-33	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	146-150
17991765-6	2008	We show further that coactivation by ARNT as well as inhibition by dioxin acts stronger on ERbeta than on ERalpha activity.	Dioxins	67-73	estrogen receptor 2	Homo sapiens	91-97
17998243-0	2008	Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome changes in 5L rat hepatoma cells reveals novel targets of dioxin action including the mitochondrial apoptosis regulator VDAC2.	Dioxins	41-47	voltage-dependent anion channel 2	Rattus norvegicus	185-190
17991765-6	2008	We show further that coactivation by ARNT as well as inhibition by dioxin acts stronger on ERbeta than on ERalpha activity.	Dioxins	67-73	estrogen receptor 1	Homo sapiens	106-113
17991765-8	2008	Taken together, our studies show that recruitment of ARNT to the AhR after dioxin treatment can account for the antiestrogenic effect of dioxins.	Dioxins	75-81	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	53-57
17991765-8	2008	Taken together, our studies show that recruitment of ARNT to the AhR after dioxin treatment can account for the antiestrogenic effect of dioxins.	Dioxins	75-81	aryl hydrocarbon receptor	Homo sapiens	65-68
17991765-8	2008	Taken together, our studies show that recruitment of ARNT to the AhR after dioxin treatment can account for the antiestrogenic effect of dioxins.	Dioxins	137-144	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	53-57
17991765-8	2008	Taken together, our studies show that recruitment of ARNT to the AhR after dioxin treatment can account for the antiestrogenic effect of dioxins.	Dioxins	137-144	aryl hydrocarbon receptor	Homo sapiens	65-68
17991765-9	2008	Moreover, we show for the first time that the inhibitory effects of dioxin are more pronounced on ERbeta than on ERalpha.	Dioxins	68-74	estrogen receptor 2	Homo sapiens	98-104
17991765-9	2008	Moreover, we show for the first time that the inhibitory effects of dioxin are more pronounced on ERbeta than on ERalpha.	Dioxins	68-74	estrogen receptor 1	Homo sapiens	113-120
18652561-1	2008	Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity of particular xenobiotics such as the dioxins, the normal role of this transcription factor in a number of biological processes is just beginning to be recognized.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	13-38
18190939-21	2008	The results support the use of the TEF methodology and suggest that immune suppression by dioxin-like chemicals may be of concern at or near background human exposures.	Dioxins	90-96	TEF transcription factor, PAR bZIP family member	Homo sapiens	35-38
18652561-1	2008	Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity of particular xenobiotics such as the dioxins, the normal role of this transcription factor in a number of biological processes is just beginning to be recognized.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	40-43
18418030-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates diverse dioxin toxicities.	Dioxins	101-107	aryl-hydrocarbon receptor	Mus musculus	4-29
18685268-5	2008	There are several microbial mechanisms responsible for biodegradation of dioxins, including oxidative degradation by dioxygenase-containing aerobic bacteria, bacterial and fungal cytochrome P-450, fungal lignolytic enzymes, reductive dechlorination by anaerobic bacteria, and direct ether ring cleavage by fungi containing etherase-like enzymes.	Dioxins	73-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	179-195
17552871-5	2008	We analyzed the effects of dexamethasone (DEX) and dioxin (TCDD) on i) expression of AhR and GRalpha mRNAs; ii) levels of AhR and GR proteins; iii) transcriptional activities of AhR and GR in reporter assays; iv) 7-ethoxyresorufin-O-deethylase activity (EROD).	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	85-88
17552871-5	2008	We analyzed the effects of dexamethasone (DEX) and dioxin (TCDD) on i) expression of AhR and GRalpha mRNAs; ii) levels of AhR and GR proteins; iii) transcriptional activities of AhR and GR in reporter assays; iv) 7-ethoxyresorufin-O-deethylase activity (EROD).	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	122-125
17552871-5	2008	We analyzed the effects of dexamethasone (DEX) and dioxin (TCDD) on i) expression of AhR and GRalpha mRNAs; ii) levels of AhR and GR proteins; iii) transcriptional activities of AhR and GR in reporter assays; iv) 7-ethoxyresorufin-O-deethylase activity (EROD).	Dioxins	51-57	nuclear receptor subfamily 3 group C member 1	Homo sapiens	93-95
17552871-5	2008	We analyzed the effects of dexamethasone (DEX) and dioxin (TCDD) on i) expression of AhR and GRalpha mRNAs; ii) levels of AhR and GR proteins; iii) transcriptional activities of AhR and GR in reporter assays; iv) 7-ethoxyresorufin-O-deethylase activity (EROD).	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	122-125
18418030-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates diverse dioxin toxicities.	Dioxins	101-107	aryl-hydrocarbon receptor	Mus musculus	31-34
18438020-1	2008	A method for the determination of dioxin like polychlorinated biphenyl (DL-PCB) residues in milk has been developed using high resolution gas chromatography coupled with ion trap mass spectrometry (GC-MS/MS-IT).	Dioxins	34-40	pyruvate carboxylase	Homo sapiens	75-78
17722095-5	2007	Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
17722095-5	2007	Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	100-103
17722095-5	2007	Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos.	Dioxins	88-94	pyruvate carboxylase	Homo sapiens	20-23
17722095-5	2007	Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos.	Dioxins	88-94	pyruvate carboxylase	Homo sapiens	100-103
17872374-0	2007	Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	41-65
17890447-1	2007	The aryl hydrocarbon receptor repressor (AhRR) is a member of the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity and is involved in regulation of cell growth and differentiation.	Dioxins	132-138	aryl hydrocarbon receptor repressor	Homo sapiens	4-39
17890447-1	2007	The aryl hydrocarbon receptor repressor (AhRR) is a member of the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity and is involved in regulation of cell growth and differentiation.	Dioxins	132-138	aryl hydrocarbon receptor repressor	Homo sapiens	41-45
17890447-1	2007	The aryl hydrocarbon receptor repressor (AhRR) is a member of the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity and is involved in regulation of cell growth and differentiation.	Dioxins	132-138	aryl hydrocarbon receptor	Homo sapiens	4-29
17890447-1	2007	The aryl hydrocarbon receptor repressor (AhRR) is a member of the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity and is involved in regulation of cell growth and differentiation.	Dioxins	132-138	aryl hydrocarbon receptor	Homo sapiens	41-44
17720151-0	2007	Functional analysis of cis-regulatory regions within the dioxin-inducible CYP1A promoter/enhancer region from zebrafish (Danio rerio).	Dioxins	57-63	cytochrome P450, family 1, subfamily A	Danio rerio	74-79
17785579-0	2007	A dioxin-responsive enhancer 3" of the human CYP1A2 gene.	Dioxins	2-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	45-51
17785579-2	2007	Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	178-184	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27
17785579-2	2007	Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	178-184	aryl hydrocarbon receptor	Homo sapiens	65-90
17785579-2	2007	Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	178-184	aryl hydrocarbon receptor	Homo sapiens	92-95
18007995-9	2007	These data suggest that some tissues may be especially vulnerable to PCBs interfering directly with TH signaling due to their capacity to express CYP1A1 in response to coplanar PCBs (or other dioxin-like molecules) if sufficient mono-ortho PCBs are present.	Dioxins	192-198	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	146-152
17956617-12	2007	CONCLUSION: i) We observed that the proportion of dioxin like (DL) compounds in the POP mixture was the dominating factor affecting the level of serum AhR transcriptional activity even at very high level of non DL-PCBs; ii) The inverse association between the integrated serum AhR transactivity and sum of POPs might be explained by the higher level of compounds antagonizing the AhR function probably due to selective POP bioaccumulation in the food chain.	Dioxins	50-56	aryl-hydrocarbon receptor	Mus musculus	151-154
17950758-3	2007	Considering the report that dioxin, an aryl hydrocarbon receptor (AhR) agonist, disrupts the transcriptional activity of ER without binding to the ER, 14 flavonoids were examined for the transcriptional activity of AhR by the yeast reporter assay (AhR).	Dioxins	28-34	aryl hydrocarbon receptor	Homo sapiens	215-218
17950758-3	2007	Considering the report that dioxin, an aryl hydrocarbon receptor (AhR) agonist, disrupts the transcriptional activity of ER without binding to the ER, 14 flavonoids were examined for the transcriptional activity of AhR by the yeast reporter assay (AhR).	Dioxins	28-34	aryl hydrocarbon receptor	Homo sapiens	215-218
17712502-3	2007	Three dioxin-like PCB congeners had a mean value of TEQ of 0.24 pg-TEQ m(-3).	Dioxins	6-12	pyruvate carboxylase	Homo sapiens	18-21
17894822-7	2007	Post-transcriptional activation of TCTP expression was associated with the action of dioxin, nickel, cobalt (1.8-2.3-fold) and copper (2.5-3.0-fold), whereas stimulation of TCTP synthesis by copper was mediated by the TCTP mRNA 3"-UTR (3.2-fold) but not by the 5"-UTR (0.5-fold).	Dioxins	85-91	tumor protein, translationally-controlled 1	Homo sapiens	35-39
17652329-1	2007	The arylhydrocarbon receptor (AhR) mediates toxicities of dioxins, including the most potent congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), by being translocated to the nucleus upon ligand-binding and inducing expression of target genes.	Dioxins	58-65	aryl hydrocarbon receptor	Homo sapiens	4-28
17576166-11	2007	We first show that AHR functions as a transactivating receptor in osteoblasts, as evidenced by its ligand-dependent migration to the nucleus and its association with known dioxin response elements.	Dioxins	172-178	aryl hydrocarbon receptor	Rattus norvegicus	19-22
17652329-1	2007	The arylhydrocarbon receptor (AhR) mediates toxicities of dioxins, including the most potent congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), by being translocated to the nucleus upon ligand-binding and inducing expression of target genes.	Dioxins	58-65	aryl hydrocarbon receptor	Homo sapiens	30-33
17636048-0	2007	Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity.	Dioxins	49-55	aryl hydrocarbon receptor	Rattus norvegicus	0-25
17636048-1	2007	The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemicals.	Dioxins	153-159	aryl hydrocarbon receptor	Rattus norvegicus	4-7
17636048-1	2007	The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemicals.	Dioxins	153-159	aryl hydrocarbon receptor	Rattus norvegicus	26-51
17636048-1	2007	The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemicals.	Dioxins	153-159	aryl hydrocarbon receptor	Rattus norvegicus	53-56
17636048-5	2007	In dioxin-sensitive rat strains and lines that are homozygous for wild-type AHR alleles, wild-type AHR mRNA is the most abundant transcript but some IV transcripts are detectable.	Dioxins	3-9	aryl hydrocarbon receptor	Rattus norvegicus	76-79
17636048-5	2007	In dioxin-sensitive rat strains and lines that are homozygous for wild-type AHR alleles, wild-type AHR mRNA is the most abundant transcript but some IV transcripts are detectable.	Dioxins	3-9	aryl hydrocarbon receptor	Rattus norvegicus	99-102
17636048-7	2007	In silico modeling indicates that the DV mRNA has lost considerable secondary structure, whereas at the protein level, the transactivation domain of the IV in the dioxin-resistant H/W rat has greater alpha-helical content and a more hydrophobic terminus than wild-type AHR, which may produce a protein conformation that is less amenable to interaction with other regulatory proteins.	Dioxins	163-169	aryl hydrocarbon receptor	Rattus norvegicus	269-272
17698510-1	2007	Dioxin-like chemicals are well known for their ability to upregulate expression of numerous genes via the AH receptor (AHR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	106-117
17707585-0	2007	Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.	Dioxins	51-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-88
17707585-4	2007	The TCDD-activated aryl hydrocarbon receptor (AhR) induces the DRE-CALUX activation and CYP1A1 gene expression via binding to DRE in promoter regions of these dioxin-responsive genes.	Dioxins	159-165	aryl hydrocarbon receptor	Homo sapiens	19-44
17707585-4	2007	The TCDD-activated aryl hydrocarbon receptor (AhR) induces the DRE-CALUX activation and CYP1A1 gene expression via binding to DRE in promoter regions of these dioxin-responsive genes.	Dioxins	159-165	aryl hydrocarbon receptor	Homo sapiens	46-49
17707585-4	2007	The TCDD-activated aryl hydrocarbon receptor (AhR) induces the DRE-CALUX activation and CYP1A1 gene expression via binding to DRE in promoter regions of these dioxin-responsive genes.	Dioxins	159-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
17707585-7	2007	This finding indicates the differential effect of arecoline on the endogenous dioxin-responsive CYP1A1 and on a stably transfected DRE-driven reporter in human hepatoma cells.	Dioxins	78-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
17698510-1	2007	Dioxin-like chemicals are well known for their ability to upregulate expression of numerous genes via the AH receptor (AHR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	119-122
17698510-4	2007	We hypothesized that microRNAs (miRNAs), which have emerged as powerful negative regulators of mRNA levels in several systems, might be responsible for mRNA downregulation in dioxin/AHR pathways.	Dioxins	175-181	aryl hydrocarbon receptor	Rattus norvegicus	182-185
18063844-7	2007	Here we observed inhibitory effects of novel MIAs on dioxin-inducible expression of CYP1A1 mRNA in rat hepatocytes.	Dioxins	53-59	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	84-90
17690134-0	2007	Glucocorticoid-enhanced expression of dioxin target genes through regulation of the rat aryl hydrocarbon receptor.	Dioxins	38-44	aryl hydrocarbon receptor	Rattus norvegicus	88-113
17690134-7	2007	Surprisingly, AhR itself was upregulated by combined dioxin/glucocorticoid exposure in rat H4IIe cells but not in the human cells which could be explained by the presence of two putative glucocorticoid response elements in the rat AhR promoter, but not in the human AhR promoter.	Dioxins	53-59	aryl hydrocarbon receptor	Rattus norvegicus	14-17
17690134-7	2007	Surprisingly, AhR itself was upregulated by combined dioxin/glucocorticoid exposure in rat H4IIe cells but not in the human cells which could be explained by the presence of two putative glucocorticoid response elements in the rat AhR promoter, but not in the human AhR promoter.	Dioxins	53-59	aryl hydrocarbon receptor	Rattus norvegicus	231-234
17690134-7	2007	Surprisingly, AhR itself was upregulated by combined dioxin/glucocorticoid exposure in rat H4IIe cells but not in the human cells which could be explained by the presence of two putative glucocorticoid response elements in the rat AhR promoter, but not in the human AhR promoter.	Dioxins	53-59	aryl hydrocarbon receptor	Homo sapiens	231-234
17690134-8	2007	This GR-mediated expression of dioxin target genes through upregulation of the AhR in rat but not in human cells opens the possibility that dioxin responses in rodent-based models for toxicity differ from humans and provides new insight into the interactions of stress-related pathways, biological effects of dioxin-like compounds and may possibly have implications for risk assessment.	Dioxins	31-37	aryl hydrocarbon receptor	Rattus norvegicus	79-82
17690134-8	2007	This GR-mediated expression of dioxin target genes through upregulation of the AhR in rat but not in human cells opens the possibility that dioxin responses in rodent-based models for toxicity differ from humans and provides new insight into the interactions of stress-related pathways, biological effects of dioxin-like compounds and may possibly have implications for risk assessment.	Dioxins	140-146	aryl hydrocarbon receptor	Rattus norvegicus	79-82
17690134-8	2007	This GR-mediated expression of dioxin target genes through upregulation of the AhR in rat but not in human cells opens the possibility that dioxin responses in rodent-based models for toxicity differ from humans and provides new insight into the interactions of stress-related pathways, biological effects of dioxin-like compounds and may possibly have implications for risk assessment.	Dioxins	140-146	aryl hydrocarbon receptor	Rattus norvegicus	79-82
17894822-1	2007	Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt.	Dioxins	215-221	tumor protein, translationally-controlled 1	Homo sapiens	24-28
17894822-3	2007	PMA, forskolin, dioxin, cobalt and nickel induced TCTP expression in 24 h in both cell lines about 2.2-3.2-fold at the mRNA level and 1.6-2.2-fold at the protein level.	Dioxins	16-22	tumor protein, translationally-controlled 1	Homo sapiens	50-54
17894822-5	2007	TPT1 promoter assays showed transcriptional activation by PMA, forskolin and dioxin (2.0-3.1-fold) and a 7.0-8.0-fold increase by copper, whereas cobalt and nickel had no effect.	Dioxins	77-83	tumor protein, translationally-controlled 1	Homo sapiens	0-4
17517823-4	2007	We found that dioxin downregulated the messenger RNAs for the G-protein-coupled receptor, CXCR4, as well as its unique chemokine ligand, CXCL12, in MCF-7 breast cancer cells.	Dioxins	14-20	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
17556759-1	2007	Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induce various toxic effects through the aryl hydrocarbon receptor (AhR) signaling pathway.	Dioxins	0-7	aryl hydrocarbon receptor-like	Phalacrocorax carbo	102-127
17556759-1	2007	Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induce various toxic effects through the aryl hydrocarbon receptor (AhR) signaling pathway.	Dioxins	0-7	aryl hydrocarbon receptor-like	Phalacrocorax carbo	129-132
17517823-4	2007	We found that dioxin downregulated the messenger RNAs for the G-protein-coupled receptor, CXCR4, as well as its unique chemokine ligand, CXCL12, in MCF-7 breast cancer cells.	Dioxins	14-20	C-X-C motif chemokine ligand 12	Homo sapiens	137-143
17517823-7	2007	Utilizing an in vitro chemotaxis assay, we demonstrate that dioxin specifically inhibits the migration of MCF-7 cells toward CXCL12.	Dioxins	60-66	C-X-C motif chemokine ligand 12	Homo sapiens	125-131
17579044-2	2007	Aryl hydrocarbon receptor (AhR) activation by the pollutant dioxin during influenza virus infection decreases survival, which correlates with a 4-fold increase in pulmonary IFN-gamma levels.	Dioxins	60-66	aryl-hydrocarbon receptor	Mus musculus	27-30
17517823-8	2007	We also show that dioxin reduces CXCR4 under hypoxia and CXCL12 under estradiol-induced conditions in MCF-7 cells.	Dioxins	18-24	C-X-C motif chemokine receptor 4	Homo sapiens	33-38
17517823-8	2007	We also show that dioxin reduces CXCR4 under hypoxia and CXCL12 under estradiol-induced conditions in MCF-7 cells.	Dioxins	18-24	C-X-C motif chemokine ligand 12	Homo sapiens	57-63
17517823-9	2007	Finally, as the CXCR4/CXCL12 axis is implicated in the progression of numerous types of cancer, we identified several other cancer cell lines in which dioxin modulates CXCR4 and CXCL12 levels.	Dioxins	151-157	C-X-C motif chemokine receptor 4	Homo sapiens	16-21
17517823-9	2007	Finally, as the CXCR4/CXCL12 axis is implicated in the progression of numerous types of cancer, we identified several other cancer cell lines in which dioxin modulates CXCR4 and CXCL12 levels.	Dioxins	151-157	C-X-C motif chemokine ligand 12	Homo sapiens	22-28
17517823-9	2007	Finally, as the CXCR4/CXCL12 axis is implicated in the progression of numerous types of cancer, we identified several other cancer cell lines in which dioxin modulates CXCR4 and CXCL12 levels.	Dioxins	151-157	C-X-C motif chemokine receptor 4	Homo sapiens	168-173
17517823-9	2007	Finally, as the CXCR4/CXCL12 axis is implicated in the progression of numerous types of cancer, we identified several other cancer cell lines in which dioxin modulates CXCR4 and CXCL12 levels.	Dioxins	151-157	C-X-C motif chemokine ligand 12	Homo sapiens	178-184
17517823-10	2007	We therefore propose that one mechanism whereby dioxin may protect against breast cancer is via downregulation of CXCR4 and CXCL12, thereby inhibiting progression of the disease.	Dioxins	48-54	C-X-C motif chemokine receptor 4	Homo sapiens	114-119
17517823-10	2007	We therefore propose that one mechanism whereby dioxin may protect against breast cancer is via downregulation of CXCR4 and CXCL12, thereby inhibiting progression of the disease.	Dioxins	48-54	C-X-C motif chemokine ligand 12	Homo sapiens	124-130
17579044-2	2007	Aryl hydrocarbon receptor (AhR) activation by the pollutant dioxin during influenza virus infection decreases survival, which correlates with a 4-fold increase in pulmonary IFN-gamma levels.	Dioxins	60-66	interferon gamma	Mus musculus	173-182
17579044-5	2007	Bone marrow chimeric mice reveal that AhR-mediated events external to hemopoietic cells direct dioxin-enhanced IFN-gamma production.	Dioxins	95-101	aryl-hydrocarbon receptor	Mus musculus	38-41
17579044-5	2007	Bone marrow chimeric mice reveal that AhR-mediated events external to hemopoietic cells direct dioxin-enhanced IFN-gamma production.	Dioxins	95-101	interferon gamma	Mus musculus	111-120
17475378-6	2007	Here, we propose a scheme for developing relative potency estimates (REP) for the PCB congeners not considered in the TEF scheme used to assess the toxicity of coplanar and mono-ortho-PCBs and chlorinated dioxins and furans.	Dioxins	205-212	pyruvate carboxylase	Homo sapiens	82-85
17070097-1	2007	The aryl hydrocarbon receptor is a ligand activated transcription factor which regulates biological responses to a variety of environmental pollutants, such as dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and cigarette smoke.	Dioxins	160-166	aryl hydrocarbon receptor	Homo sapiens	4-29
17569696-4	2007	This giant step led to our current view that essentially all toxic effects of dioxins are AHR-mediated.	Dioxins	78-85	aryl hydrocarbon receptor	Homo sapiens	90-93
17654340-3	2007	With partial least squares (PLS) analysis and variable importance in the projection (VIP), the least significant descriptors were removed from the quantitative structure-activity relationship (QSAR), which was focused on exploring the influential factors responsible for the variance of binding affinities of dioxins to aryl hydrocarbon receptor (AhR).	Dioxins	309-316	aryl hydrocarbon receptor	Homo sapiens	320-345
17654340-3	2007	With partial least squares (PLS) analysis and variable importance in the projection (VIP), the least significant descriptors were removed from the quantitative structure-activity relationship (QSAR), which was focused on exploring the influential factors responsible for the variance of binding affinities of dioxins to aryl hydrocarbon receptor (AhR).	Dioxins	309-316	aryl hydrocarbon receptor	Homo sapiens	347-350
17569696-7	2007	In laboratory animals genetic differences in AHR gene structure lead to profound differences in responsiveness to dioxin-like chemicals.	Dioxins	114-120	aryl hydrocarbon receptor	Homo sapiens	45-48
17569696-9	2007	Dioxin toxicity is fundamentally due to AHR-mediated dysregulation of gene expression.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	40-43
17569696-11	2007	Mapping AHR-mediated gene expression in a variety of biological systems may help explain why dramatic differences in susceptibility to dioxin toxicity exist among laboratory species and why humans appear to be relatively resistant to adverse effects of dioxins.	Dioxins	135-141	aryl hydrocarbon receptor	Homo sapiens	8-11
17569696-11	2007	Mapping AHR-mediated gene expression in a variety of biological systems may help explain why dramatic differences in susceptibility to dioxin toxicity exist among laboratory species and why humans appear to be relatively resistant to adverse effects of dioxins.	Dioxins	253-260	aryl hydrocarbon receptor	Homo sapiens	8-11
17327465-1	2007	Expression of Cyp1a1 and its related enzyme activity have long been used as a biomarker for aryl hydrocarbon receptor (AhR) activation and a warning of dioxin-like toxicity.	Dioxins	152-158	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
16823400-0	2007	Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States population.	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	37-40
17266942-1	2007	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with important roles in metabolic adaptation, normal physiology and dioxin toxicology.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	4-29
17266942-1	2007	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with important roles in metabolic adaptation, normal physiology and dioxin toxicology.	Dioxins	147-153	aryl hydrocarbon receptor	Homo sapiens	31-34
17336149-5	2007	We present here first results on PCDD, PCDF and dioxin-like PCB (dl-PCB) concentrations in breast milk of 43 women living in Bavaria, Germany.	Dioxins	48-54	pyruvate carboxylase	Homo sapiens	60-63
17400515-10	2007	We propose that CYP1A5 mRNA expression may be a sensitive biomarker of exposure to dioxin-like compounds in some avian species.	Dioxins	83-89	cytochrome P450 1A2	Gallus gallus	16-22
17616719-1	2007	The arylhydrocarbon receptor (AhR) mediates the adverse effects of dioxin-like compounds.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	4-28
17616719-1	2007	The arylhydrocarbon receptor (AhR) mediates the adverse effects of dioxin-like compounds.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	30-33
17316563-0	2007	Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.	Dioxins	80-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-41
17277313-0	2007	A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.	Dioxins	147-153	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	120-138
17277313-1	2007	Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR).	Dioxins	127-133	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	0-18
17277313-1	2007	Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR).	Dioxins	127-133	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	20-26
17337447-1	2007	The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) causes numerous and diverse toxic events via activation of the aryl hydrocarbon receptor, including atrophy of the thymus.	Dioxins	57-63	aryl-hydrocarbon receptor	Mus musculus	142-167
17316563-0	2007	Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.	Dioxins	80-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
17277313-1	2007	Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR).	Dioxins	127-133	aryl-hydrocarbon receptor	Mus musculus	151-176
17277313-1	2007	Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR).	Dioxins	127-133	aryl-hydrocarbon receptor	Mus musculus	178-181
17258273-0	2007	PCB and dioxin-like PCB in indoor air of public buildings contaminated with different PCB sources--deriving toxicity equivalent concentrations from standard PCB congeners.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
17277313-3	2007	Approximately 400 nucleotides upstream of its translational initiation codon, mouse Cyp2s1 contains three overlapping xenobiotic-responsive element (XRE) sequences, which make a major contribution toward dioxin inducibility.	Dioxins	204-210	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	84-90
17277313-4	2007	Each XRE sequence in this trimeric XRE can bind the AHR/aryl hydrocarbon receptor nuclear translocator (ARNT) dimer in a dioxin-dependent fashion in vitro and can mediate dioxin-dependent transcription.	Dioxins	121-127	aryl hydrocarbon receptor nuclear translocator	Mus musculus	52-102
17277313-4	2007	Each XRE sequence in this trimeric XRE can bind the AHR/aryl hydrocarbon receptor nuclear translocator (ARNT) dimer in a dioxin-dependent fashion in vitro and can mediate dioxin-dependent transcription.	Dioxins	121-127	aryl hydrocarbon receptor nuclear translocator	Mus musculus	104-108
17277313-4	2007	Each XRE sequence in this trimeric XRE can bind the AHR/aryl hydrocarbon receptor nuclear translocator (ARNT) dimer in a dioxin-dependent fashion in vitro and can mediate dioxin-dependent transcription.	Dioxins	171-177	aryl hydrocarbon receptor nuclear translocator	Mus musculus	52-102
17277313-4	2007	Each XRE sequence in this trimeric XRE can bind the AHR/aryl hydrocarbon receptor nuclear translocator (ARNT) dimer in a dioxin-dependent fashion in vitro and can mediate dioxin-dependent transcription.	Dioxins	171-177	aryl hydrocarbon receptor nuclear translocator	Mus musculus	104-108
17277313-8	2007	AHR/ARNT and HIF-1alpha/ARNT dimers bind to the region containing the trimeric XRE segment of the endogenous Cyp2s1 gene in vivo in a dioxin-dependent fashion and hypoxia-dependent fashion, respectively.	Dioxins	134-140	aryl-hydrocarbon receptor	Mus musculus	0-3
17277313-8	2007	AHR/ARNT and HIF-1alpha/ARNT dimers bind to the region containing the trimeric XRE segment of the endogenous Cyp2s1 gene in vivo in a dioxin-dependent fashion and hypoxia-dependent fashion, respectively.	Dioxins	134-140	aryl hydrocarbon receptor nuclear translocator	Mus musculus	4-8
17277313-8	2007	AHR/ARNT and HIF-1alpha/ARNT dimers bind to the region containing the trimeric XRE segment of the endogenous Cyp2s1 gene in vivo in a dioxin-dependent fashion and hypoxia-dependent fashion, respectively.	Dioxins	134-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	13-23
17277313-8	2007	AHR/ARNT and HIF-1alpha/ARNT dimers bind to the region containing the trimeric XRE segment of the endogenous Cyp2s1 gene in vivo in a dioxin-dependent fashion and hypoxia-dependent fashion, respectively.	Dioxins	134-140	aryl hydrocarbon receptor nuclear translocator	Mus musculus	24-28
17277313-8	2007	AHR/ARNT and HIF-1alpha/ARNT dimers bind to the region containing the trimeric XRE segment of the endogenous Cyp2s1 gene in vivo in a dioxin-dependent fashion and hypoxia-dependent fashion, respectively.	Dioxins	134-140	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	109-115
17285236-1	2007	Dioxin and dioxin-like activity in sediments of the North Sea, along the Belgian coast, was assessed with the bioassay CALUX (Chemically Activated LUciferase gene eXpression).	Dioxins	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
17234249-13	2007	Sampling of household dust and water sediment within and outside of residences within a 2-mile radius of the plant revealed the presence of significantly elevated levels of dioxins, principally octachlorodibenzo-p-dioxin (OCDD) and 1,2,3,4,6,7,8-hepta-CDD.	Dioxins	173-180	natriuretic peptide A	Homo sapiens	223-226
17258273-0	2007	PCB and dioxin-like PCB in indoor air of public buildings contaminated with different PCB sources--deriving toxicity equivalent concentrations from standard PCB congeners.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
17258273-0	2007	PCB and dioxin-like PCB in indoor air of public buildings contaminated with different PCB sources--deriving toxicity equivalent concentrations from standard PCB congeners.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
17258273-1	2007	Data on dioxin-like PCB in indoor air of buildings with PCB-containing materials and on possible correlation between toxicity equivalent concentrations (TEQ) and levels of non-dioxin-like standard PCB is sparse.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
17258273-2	2007	As part of a larger survey on indoor-air contamination with PCB, the connection between the concentration of standard PCB congeners and the dioxin-like toxicity expressed as TEQ was investigated.	Dioxins	140-146	pyruvate carboxylase	Homo sapiens	118-121
17258273-7	2007	Linear regression analysis between PCB and TEQ indicated that PCB 118 might be used to calculate the total TEQ of dioxin-like PCB and PCDD/PCDF.	Dioxins	114-120	pyruvate carboxylase	Homo sapiens	35-38
17285236-0	2007	Dioxin and dioxin-like activity in sediments of the Belgian coastal area (Southern North Sea).	Dioxins	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
17258273-7	2007	Linear regression analysis between PCB and TEQ indicated that PCB 118 might be used to calculate the total TEQ of dioxin-like PCB and PCDD/PCDF.	Dioxins	114-120	pyruvate carboxylase	Homo sapiens	62-65
17285236-0	2007	Dioxin and dioxin-like activity in sediments of the Belgian coastal area (Southern North Sea).	Dioxins	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
17258273-7	2007	Linear regression analysis between PCB and TEQ indicated that PCB 118 might be used to calculate the total TEQ of dioxin-like PCB and PCDD/PCDF.	Dioxins	114-120	pyruvate carboxylase	Homo sapiens	62-65
16797713-0	2007	Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure.	Dioxins	83-89	receptor for activated C kinase 1	Homo sapiens	44-50
17222440-6	2007	Furthermore effects of dioxins, DDT and PCBs on the percentage of CD16+ T lymphocyte were more pronounced by the combined exposure of dioxins and PCBs or by the combined exposure of DDT and PCBs.	Dioxins	23-30	Fc gamma receptor IIIa	Homo sapiens	66-70
17222440-6	2007	Furthermore effects of dioxins, DDT and PCBs on the percentage of CD16+ T lymphocyte were more pronounced by the combined exposure of dioxins and PCBs or by the combined exposure of DDT and PCBs.	Dioxins	134-141	Fc gamma receptor IIIa	Homo sapiens	66-70
17223167-0	2007	Dioxin concentrations in sediments of the Baltic Sea--a survey of existing data.	Dioxins	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	49-52
17223168-3	2007	In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12 commercially available humic substances.	Dioxins	188-194	aryl hydrocarbon receptor	Homo sapiens	149-152
17223171-6	2007	In November 2000 the Scientific Committee on Food of the European Commission published an "Opinion of the SCF on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food" [SCF, Scientific Committee on Food 2000.	Dioxins	136-143	KIT ligand	Homo sapiens	106-109
17223171-6	2007	In November 2000 the Scientific Committee on Food of the European Commission published an "Opinion of the SCF on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food" [SCF, Scientific Committee on Food 2000.	Dioxins	136-143	KIT ligand	Homo sapiens	175-178
17223171-6	2007	In November 2000 the Scientific Committee on Food of the European Commission published an "Opinion of the SCF on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food" [SCF, Scientific Committee on Food 2000.	Dioxins	136-142	KIT ligand	Homo sapiens	106-109
17223171-6	2007	In November 2000 the Scientific Committee on Food of the European Commission published an "Opinion of the SCF on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food" [SCF, Scientific Committee on Food 2000.	Dioxins	136-142	KIT ligand	Homo sapiens	175-178
17223171-7	2007	Opinion of the SCF on the risk assessment of dioxins and dioxin-like PCBs in food.	Dioxins	45-52	KIT ligand	Homo sapiens	15-18
17223171-7	2007	Opinion of the SCF on the risk assessment of dioxins and dioxin-like PCBs in food.	Dioxins	45-51	KIT ligand	Homo sapiens	15-18
17223171-13	2007	The SCF stated that on a body weight basis, the dioxin intake of breast-fed infants has been estimated to be one to two orders of magnitude higher than the average adult intake.	Dioxins	48-54	KIT ligand	Homo sapiens	4-7
17134732-10	2007	While the concentration of PCB increased significantly in the primary combustion chamber, the value of toxicity equivalency quantity for dioxin-like PCB decreased in the secondary combustion chamber and the flue gas treatment equipments.	Dioxins	137-143	pyruvate carboxylase	Homo sapiens	149-152
17207841-5	2007	After adding dioxin-like mono-ortho-PCBs the total PCB-TEQ concentrations ranged from 3.8 to 13.3 pg WHO-TEQ/g fat (mean value: 8.7 pg WHO-TEQ/g fat).	Dioxins	13-19	pyruvate carboxylase	Homo sapiens	36-39
17207842-17	2007	PCDD/F and dioxin-like PCB in human blood and milk from German mothers.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
17208274-11	2007	In conclusion, the 1999 PCB/dioxin incident was traceable in the plasma profiles (rise of the two specific PCDF congeners), but comparison of the results for both years indicates that the changes were too small to cause an adverse public health effect.	Dioxins	28-34	pyruvate carboxylase	Homo sapiens	24-27
17012224-2	2007	The AHR/ARNT dimer regulates the expression of its target genes by binding to DNA recognition elements termed dioxin responsive elements (DREs).	Dioxins	110-116	aryl hydrocarbon receptor	Homo sapiens	4-7
17012224-2	2007	The AHR/ARNT dimer regulates the expression of its target genes by binding to DNA recognition elements termed dioxin responsive elements (DREs).	Dioxins	110-116	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	8-12
17624025-2	2007	In addition to several clones representing known dioxin-inducible genes, several clones were isolated that represented genes that were previously not known to be inducible by dioxin, including B94 (also known as tumour necrosis factor alpha-induced protein 2 (Tnfaip2), Seven in absentia homologue 2 (Siah2), the mouse homologue of Bob/Gpr15, and S-adenosyl-homocysteine hydrolase (Sahh, Ahcy).	Dioxins	175-181	tumor necrosis factor, alpha-induced protein 2	Mus musculus	212-258
17593761-6	2007	Dioxin-like and TTR-binding activities in sulfuric acid treatment extracts of house and office dust were investigated using Dioxin-Responsive Chemical-Activated LUciferase gene eXpression assay (DR-CALUX) and TTR-binding assay (in vitro competitive human TTR-binding assay).	Dioxins	0-6	transthyretin	Homo sapiens	209-212
17593761-6	2007	Dioxin-like and TTR-binding activities in sulfuric acid treatment extracts of house and office dust were investigated using Dioxin-Responsive Chemical-Activated LUciferase gene eXpression assay (DR-CALUX) and TTR-binding assay (in vitro competitive human TTR-binding assay).	Dioxins	0-6	transthyretin	Homo sapiens	209-212
17593761-6	2007	Dioxin-like and TTR-binding activities in sulfuric acid treatment extracts of house and office dust were investigated using Dioxin-Responsive Chemical-Activated LUciferase gene eXpression assay (DR-CALUX) and TTR-binding assay (in vitro competitive human TTR-binding assay).	Dioxins	124-130	transthyretin	Homo sapiens	16-19
17593761-6	2007	Dioxin-like and TTR-binding activities in sulfuric acid treatment extracts of house and office dust were investigated using Dioxin-Responsive Chemical-Activated LUciferase gene eXpression assay (DR-CALUX) and TTR-binding assay (in vitro competitive human TTR-binding assay).	Dioxins	124-130	transthyretin	Homo sapiens	209-212
17593761-6	2007	Dioxin-like and TTR-binding activities in sulfuric acid treatment extracts of house and office dust were investigated using Dioxin-Responsive Chemical-Activated LUciferase gene eXpression assay (DR-CALUX) and TTR-binding assay (in vitro competitive human TTR-binding assay).	Dioxins	124-130	transthyretin	Homo sapiens	209-212
17593761-7	2007	Dioxin-like activities in indoor dust were 38-1400 pg CALUX-TEQ (2,3,7,8-TCDD equivalent)/g (median 160 pg CALUX-TEQ/g) and TTR-binding potencies were 300-5000 pmol T4EQ (thyroxine (T4) equivalent)/g (median 1000 pmol T4EQ/g), which are higher values than those in other environmental samples, e.g., contaminated sediments.	Dioxins	0-6	transthyretin	Homo sapiens	124-127
16962637-6	2007	Samples were analyzed for PCDD/F and twelve dioxin-like PCB congeners using high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS).	Dioxins	44-50	pyruvate carboxylase	Homo sapiens	56-59
17223712-0	2007	Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.	Dioxins	36-42	C-terminal Src kinase	Homo sapiens	20-32
17223712-0	2007	Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.	Dioxins	36-42	cell division cycle 37, HSP90 cochaperone	Homo sapiens	62-67
17223712-0	2007	Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.	Dioxins	36-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-73
17223712-0	2007	Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.	Dioxins	36-42	aryl hydrocarbon receptor	Homo sapiens	93-104
17223712-1	2007	We investigated the mechanism by which activation of the Ah receptor by dioxin (TCDD) was accompanied by rapid activation of c-Src kinase activity.	Dioxins	72-78	aryl hydrocarbon receptor	Homo sapiens	57-68
17223712-1	2007	We investigated the mechanism by which activation of the Ah receptor by dioxin (TCDD) was accompanied by rapid activation of c-Src kinase activity.	Dioxins	72-78	C-terminal Src kinase	Homo sapiens	125-137
17137551-1	2007	Inducibility of the cytochrome P4501A4 (CYP1A4) enzyme, measured as ethoxyresorufin-O-deethylase (EROD) activity, has been used as a biomarker for sensitivity to the effects of dioxin-like compounds in avian species.	Dioxins	177-183	cytochrome P450 1A4	Gallus gallus	20-38
17137551-1	2007	Inducibility of the cytochrome P4501A4 (CYP1A4) enzyme, measured as ethoxyresorufin-O-deethylase (EROD) activity, has been used as a biomarker for sensitivity to the effects of dioxin-like compounds in avian species.	Dioxins	177-183	cytochrome P450 1A4	Gallus gallus	40-46
16962637-7	2007	This study is very important since it is the first report on PCDDs/Fs and dioxin-like PCB contamination in human adipose tissue from Turkey.	Dioxins	74-80	pyruvate carboxylase	Homo sapiens	86-89
17269455-7	2007	Kinetic parameters were used to predict the level of WHO-TEF dioxins and DLPCBs in Atlantic salmon reared in a large-scale facility under commercial conditions.	Dioxins	61-68	thyrotrophic embryonic factor	Salmo salar	57-60
21959539-4	2007	The aim with the present work was to identify compound groups with AhR agonistic properties that caused the previously reported increase in dioxin-like activity after anaerobic biodegradation METHODS: Firstly, chemical fractionation combined with dioxin bioassay testing was used to find bioactive classes of compounds.	Dioxins	140-146	aryl hydrocarbon receptor	Homo sapiens	67-70
21959539-4	2007	The aim with the present work was to identify compound groups with AhR agonistic properties that caused the previously reported increase in dioxin-like activity after anaerobic biodegradation METHODS: Firstly, chemical fractionation combined with dioxin bioassay testing was used to find bioactive classes of compounds.	Dioxins	247-253	aryl hydrocarbon receptor	Homo sapiens	67-70
21959539-7	2007	Two different dioxin-specific bioassays were used to analyse AhR agonists in the biodegraded material, the CELCAD and the DR-CALUX.	Dioxins	14-20	aryl hydrocarbon receptor	Homo sapiens	61-64
17185382-0	2007	Comments on "calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor".	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	87-112
17156822-2	2007	In this study, we tried to validate DRE (dioxin-response elements)-CALUX bioassay, which has been developed by cloning mouse cyp1a1 gene in front of luciferase reporter gene.	Dioxins	41-47	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	125-131
17020875-1	2007	The aryl hydrocarbon receptor (AhR) mediates adverse effects of dioxins, but its physiological role remains ambiguous.	Dioxins	64-71	aryl hydrocarbon receptor	Rattus norvegicus	4-29
17020875-1	2007	The aryl hydrocarbon receptor (AhR) mediates adverse effects of dioxins, but its physiological role remains ambiguous.	Dioxins	64-71	aryl hydrocarbon receptor	Rattus norvegicus	31-34
17035482-4	2007	We developed a transgenic (TG) mouse model to delineate the temporal and spatial context of transcriptionally active AhR by utilizing a dioxin responsive element-linked LacZ reporter system.	Dioxins	136-142	aryl-hydrocarbon receptor	Mus musculus	117-120
17112560-2	2006	For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers.	Dioxins	103-109	aryl hydrocarbon receptor 1a	Danio rerio	155-180
17112560-2	2006	For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers.	Dioxins	103-109	aryl hydrocarbon receptor 1a	Danio rerio	182-185
17112560-2	2006	For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers.	Dioxins	103-109	cytochrome P450, family 1, subfamily A	Danio rerio	258-275
17112560-2	2006	For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers.	Dioxins	103-109	cytochrome P450, family 1, subfamily A	Danio rerio	277-282
17112691-2	2006	Because endometriosis is an estrogen-dependent disease and since aromatase (CYP19), a key enzyme in estrogen biosynthesis, was recently demonstrated to be expressed in endometriotic lesions, we hypothesized that dioxin-like compounds could modulate local estrogen production through an up-regulation of aromatase.	Dioxins	212-218	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-81
16765418-0	2006	PCDD/F and "Dioxin-like" PCB emissions from iron ore sintering plants in the UK.	Dioxins	12-18	pyruvate carboxylase	Homo sapiens	25-28
17256505-5	2006	PCBs clustered into seven groups, five of which contained a single "dioxin like" PCB, one contained lighter congeners (2-4 chlorines), and one contained heavy congeners (5-10 chlorines).	Dioxins	68-74	pyruvate carboxylase	Homo sapiens	0-3
16985168-11	2006	These findings implicate AhR-dependent up-regulation of TGM1 mRNA in differentiating keratinocytes as one mechanism contributing toward chloracne in humans exposed to toxic levels of dioxin.	Dioxins	183-189	aryl hydrocarbon receptor	Homo sapiens	25-28
16985168-11	2006	These findings implicate AhR-dependent up-regulation of TGM1 mRNA in differentiating keratinocytes as one mechanism contributing toward chloracne in humans exposed to toxic levels of dioxin.	Dioxins	183-189	transglutaminase 1	Homo sapiens	56-60
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Dioxins	35-41	aryl hydrocarbon receptor	Homo sapiens	97-100
17090139-6	2006	It is proposed from these results that some flavonoids have the ability to suppress dioxin-induced AhR activity after permeating the human intestinal epithelial cell monolayer.	Dioxins	84-90	aryl hydrocarbon receptor	Homo sapiens	99-102
16597458-5	2006	Pregnant women residing in the study area >3 years had significantly higher PCDD (7.48 versus 5.13 pg-toxic equivalents [TEQ]/g-lipid) and dioxin-like PCB (6.70 versus 3.74 pg-TEQ/g-lipid) values as compared to those residing < or = 3 years.	Dioxins	142-148	pyruvate carboxylase	Homo sapiens	154-157
17107852-5	2006	RESULTS: We found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and nuclear transcription factor kappa B (NFkappaB), a marker of inflammation.	Dioxins	73-79	solute carrier family 2 member 4	Homo sapiens	124-145
17090139-0	2006	TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.	Dioxins	44-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Dioxins	35-42	aryl hydrocarbon receptor	Homo sapiens	70-95
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Dioxins	35-42	aryl hydrocarbon receptor	Homo sapiens	97-100
17107852-5	2006	RESULTS: We found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and nuclear transcription factor kappa B (NFkappaB), a marker of inflammation.	Dioxins	73-79	solute carrier family 2 member 4	Homo sapiens	147-152
17107852-5	2006	RESULTS: We found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and nuclear transcription factor kappa B (NFkappaB), a marker of inflammation.	Dioxins	73-79	nuclear factor kappa B subunit 1	Homo sapiens	158-194
17107852-5	2006	RESULTS: We found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and nuclear transcription factor kappa B (NFkappaB), a marker of inflammation.	Dioxins	73-79	nuclear factor kappa B subunit 1	Homo sapiens	196-204
17107852-8	2006	CONCLUSIONS: These results show that the GLUT4:NFkappaB ratio is a reliable marker for the diabetogenic action of dioxin, particularly at very low exposure levels that are not much higher than those found in the general public, implying a need to address current exposure levels.	Dioxins	114-120	solute carrier family 2 member 4	Homo sapiens	41-46
17107852-8	2006	CONCLUSIONS: These results show that the GLUT4:NFkappaB ratio is a reliable marker for the diabetogenic action of dioxin, particularly at very low exposure levels that are not much higher than those found in the general public, implying a need to address current exposure levels.	Dioxins	114-120	nuclear factor kappa B subunit 1	Homo sapiens	47-55
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	17-23	spineless	Drosophila melanogaster	54-79
16891617-0	2006	Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor.	Dioxins	21-27	aryl-hydrocarbon receptor	Mus musculus	74-99
17342196-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
17342196-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
17342196-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
17342196-4	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
17342196-8	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
17342196-9	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	60-66	pyruvate carboxylase	Rattus norvegicus	39-42
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	60-66	pyruvate carboxylase	Rattus norvegicus	103-106
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	60-66	pyruvate carboxylase	Rattus norvegicus	103-106
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	60-66	pyruvate carboxylase	Rattus norvegicus	103-106
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	60-66	pyruvate carboxylase	Rattus norvegicus	103-106
17342196-17	2006	Given the 1,000-fold higher potency of PCB 126 for inducing dioxin-like effects (based on the TEFs for PCB 126 and PCB 118 of 0.1 and 0.0001, respectively), it was expected that the effects of administration of this compound would be due to the combined dioxin-like effects of both PCB 126 and PCB 118.	Dioxins	254-260	pyruvate carboxylase	Rattus norvegicus	39-42
17342196-34	2006	Cytochrome P450 Enzyme Activities: CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activities were evaluated at the 14-, 31-, and 53-week interim evaluations to evaluate the expression of known dioxin-responsive genes.	Dioxins	256-262	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
17342196-34	2006	Cytochrome P450 Enzyme Activities: CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activities were evaluated at the 14-, 31-, and 53-week interim evaluations to evaluate the expression of known dioxin-responsive genes.	Dioxins	256-262	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-41
17342196-34	2006	Cytochrome P450 Enzyme Activities: CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activities were evaluated at the 14-, 31-, and 53-week interim evaluations to evaluate the expression of known dioxin-responsive genes.	Dioxins	256-262	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	95-101
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	17-23	spineless	Drosophila melanogaster	81-84
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	17-23	spineless	Drosophila melanogaster	138-141
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	17-23	tango	Drosophila melanogaster	143-167
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	17-23	tango	Drosophila melanogaster	169-173
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	54-79
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	81-84
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	138-141
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	tango	Drosophila melanogaster	143-167
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	tango	Drosophila melanogaster	169-173
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	54-79
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	81-84
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	spineless	Drosophila melanogaster	138-141
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	tango	Drosophila melanogaster	143-167
17037913-2	2006	It is known that dioxin ligand can bind heterodimeric aryl hydrocarbon receptor (AhR) and triggers the formation of the complex of dioxin-AhR, AhR nuclear translocator (ARNT), and dioxin-responsive element (DRE) region of the DNA.	Dioxins	131-137	tango	Drosophila melanogaster	169-173
16713074-3	2006	We also established a dioxin-responsive element (DRE)-mediated Chemical Activated LUciferase eXpression (CALUX) cell line, Huh7-DRE-Luc, by stable transfection of Huh7 with a DRE-driven firefly luciferase reporter plasmid (4xDRE-TATA-Luc).	Dioxins	22-28	MIR7-3 host gene	Homo sapiens	123-127
17040097-1	2006	The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively.	Dioxins	155-162	aryl hydrocarbon receptor	Homo sapiens	4-29
17040097-1	2006	The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively.	Dioxins	155-162	aryl hydrocarbon receptor	Homo sapiens	31-34
17009211-4	2006	Toxic equivalency factors have been established for the other PCDD, PCDF and dioxin-like PCB relative to TCDD, and the combined toxicity of a sample can be expressed as toxic equivalent (WHO-TEQ).	Dioxins	77-83	pyruvate carboxylase	Homo sapiens	89-92
16713074-3	2006	We also established a dioxin-responsive element (DRE)-mediated Chemical Activated LUciferase eXpression (CALUX) cell line, Huh7-DRE-Luc, by stable transfection of Huh7 with a DRE-driven firefly luciferase reporter plasmid (4xDRE-TATA-Luc).	Dioxins	22-28	MIR7-3 host gene	Homo sapiens	163-167
16759845-3	2006	Among these antibodies, ScFv showed excellent capability for dioxin detection using QCM immunosensors.	Dioxins	61-67	immunglobulin heavy chain variable region	Homo sapiens	24-28
16765350-1	2006	PCB 77 is a dioxin-like PCB that has been shown to reduce circulating thyroid hormone (TH) levels.	Dioxins	12-18	parathyroid hormone	Gallus gallus	70-85
16765350-1	2006	PCB 77 is a dioxin-like PCB that has been shown to reduce circulating thyroid hormone (TH) levels.	Dioxins	12-18	parathyroid hormone	Gallus gallus	87-89
16956419-3	2006	A major participant in the process of the dioxin-toxicity is the dioxin receptor, namely the aryl hydrocarbon receptor (AhR).	Dioxins	42-48	aryl hydrocarbon receptor	Homo sapiens	93-118
16750337-1	2006	The TEF system for dioxin-like compounds has included assignment of TEF values for mono-ortho polychlorinated biphenyls (MO-PCBs).	Dioxins	19-25	thyrotroph embryonic factor	Mus musculus	4-7
16750337-1	2006	The TEF system for dioxin-like compounds has included assignment of TEF values for mono-ortho polychlorinated biphenyls (MO-PCBs).	Dioxins	19-25	thyrotroph embryonic factor	Mus musculus	68-71
16956419-3	2006	A major participant in the process of the dioxin-toxicity is the dioxin receptor, namely the aryl hydrocarbon receptor (AhR).	Dioxins	42-48	aryl hydrocarbon receptor	Homo sapiens	120-123
16956419-5	2006	Since the AhR has also been detected in various regions of the brain, the AhR may play a key role in the developmental neurotoxicity of dioxins.	Dioxins	136-143	aryl-hydrocarbon receptor	Mus musculus	10-13
16956419-5	2006	Since the AhR has also been detected in various regions of the brain, the AhR may play a key role in the developmental neurotoxicity of dioxins.	Dioxins	136-143	aryl-hydrocarbon receptor	Mus musculus	74-77
16956419-20	2006	This result revealed that dioxins may affect the nervous system through the AhR-signaling pathway.	Dioxins	26-33	aryl-hydrocarbon receptor	Mus musculus	76-79
16489453-0	2006	Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant.	Dioxins	18-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	73-79
16972786-7	2006	This short overview summarizes the present knowledge about the AhRR and should stimulate research in the AhRR field to elucidate its physiological function and its toxicological importance in dioxin toxicity.	Dioxins	192-198	aryl hydrocarbon receptor repressor	Homo sapiens	63-67
16972786-7	2006	This short overview summarizes the present knowledge about the AhRR and should stimulate research in the AhRR field to elucidate its physiological function and its toxicological importance in dioxin toxicity.	Dioxins	192-198	aryl hydrocarbon receptor repressor	Homo sapiens	105-109
16922920-1	2006	Many of the effects of dioxins, which are potent environmental pollutants and teratogens, are mediated through the aryl hydrocarbon receptor, also known as the dioxin receptor.	Dioxins	23-30	aryl-hydrocarbon receptor	Mus musculus	115-140
16782256-4	2006	In this work we analyzed the effects of sanguinarine and chelerythrine on AhR activity in rat hepatoma cells HII4E.luc stably transfected with dioxin responsive element fused to luciferase gene (DRE-LUC).	Dioxins	143-149	aryl hydrocarbon receptor	Rattus norvegicus	74-77
16782256-7	2006	Chelerythrine (1 microM) but not sanguinarine caused moderate inhibition of AhR activation by 10 picomolar dioxin (exponential phase of receptor activation).	Dioxins	107-113	aryl hydrocarbon receptor	Rattus norvegicus	76-79
17160103-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
17160103-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
17160103-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
17160103-3	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
17160103-7	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
17160103-8	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
17160103-14	2006	The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds.	Dioxins	4-10	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	11-14
17160103-31	2006	Cytochrome P450 Enzyme Activities: To evaluate the expression of known dioxin-responsive genes, CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activity were evaluated at the 14-, 31-, and 53-week interim evaluations.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	96-102
17342195-4	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
17342195-4	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
17342195-4	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
17342195-5	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
16619036-5	2006	These dioxin-mediated effects are mimicked by constitutive expression and activation of the intracellular dioxin receptor (aryl hydrocarbon receptor (AhR)).	Dioxins	6-12	aryl hydrocarbon receptor	Homo sapiens	123-148
16619036-5	2006	These dioxin-mediated effects are mimicked by constitutive expression and activation of the intracellular dioxin receptor (aryl hydrocarbon receptor (AhR)).	Dioxins	6-12	aryl hydrocarbon receptor	Homo sapiens	150-153
17342195-9	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
16619036-7	2006	Dioxin-induced effects occur 48 h post-treatment initiation, a time scale, which argues for a genomic effect of the AhR, linked to induction of target genes.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	116-119
17342195-10	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
17342195-17	2006	The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLC"s, structurally related PCBs, and mixtures of these compounds.	Dioxins	4-10	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	11-14
17342195-33	2006	Cytochrome P450 Enzyme Activities: To evaluate the expression of known dioxin-responsive genes, CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activity were evaluated at the interim time points.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	96-102
16480812-10	2006	This ability of AhR to elicit spurious activation of retinoid receptors expands the scope of AhR ligands influence beyond ER antagonism and specific Dioxin-responsive genes.	Dioxins	149-155	aryl hydrocarbon receptor	Homo sapiens	16-19
16962184-2	2006	The AHR is activated by polycyclic aromatic hydrocarbon toxicants, including the pervasive teratogen and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin).	Dioxins	145-151	aryl-hydrocarbon receptor	Mus musculus	4-7
16885337-0	2006	Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer.	Dioxins	31-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-67
16885337-2	2006	We tested the hypothesis that cancer-related epigenetic changes suppress dioxin activation of the cytochrome P4501A1 (CYP1A1) gene.	Dioxins	73-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-116
16885337-2	2006	We tested the hypothesis that cancer-related epigenetic changes suppress dioxin activation of the cytochrome P4501A1 (CYP1A1) gene.	Dioxins	73-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
16885337-11	2006	This is the first report that shows that CYP1A1 is aberrantly hypermethylated in human prostate cancer and has an altered, inaccessible chromatin structure that suppresses its dioxin responsiveness.	Dioxins	176-182	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47
16955640-19	2006	PCB"s have similar properties to TCDD if they can exist in a planar configuration (dioxin-like PCB"s).	Dioxins	83-89	pyruvate carboxylase	Homo sapiens	0-3
16955640-19	2006	PCB"s have similar properties to TCDD if they can exist in a planar configuration (dioxin-like PCB"s).	Dioxins	83-89	pyruvate carboxylase	Homo sapiens	95-98
16955640-20	2006	The non-dioxin-like PCB"s always occur together with "dioxins"; their toxixty cannot be adequately determined although they occur in high concenrations.	Dioxins	8-14	pyruvate carboxylase	Homo sapiens	20-23
16955640-20	2006	The non-dioxin-like PCB"s always occur together with "dioxins"; their toxixty cannot be adequately determined although they occur in high concenrations.	Dioxins	54-61	pyruvate carboxylase	Homo sapiens	20-23
17160104-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
17160104-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
17160104-3	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
17160104-4	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
16679348-0	2006	Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds.	Dioxins	142-148	cytochrome P450 1A4	Phalacrocorax carbo	0-27
16762319-4	2006	Overexpression of NcoA4 enhanced AhR transcriptional activity 3.2-fold in the presence of dioxin, whereas overexpression of a splice variant, NcoA4beta, as well as a variant lacking the C-terminal region enhanced AhR transcriptional activity by only 1.6-fold.	Dioxins	90-96	nuclear receptor coactivator 4	Homo sapiens	18-23
16762319-6	2006	NcoA4 protein localized to cytoplasm in the absence of dioxin and in both the cytoplasm and nucleus following dioxin treatment.	Dioxins	55-61	nuclear receptor coactivator 4	Homo sapiens	0-5
16762319-6	2006	NcoA4 protein localized to cytoplasm in the absence of dioxin and in both the cytoplasm and nucleus following dioxin treatment.	Dioxins	110-116	nuclear receptor coactivator 4	Homo sapiens	0-5
16849560-12	2006	These results evidenced for the first time that cigarette smoke has unexpectedly high dioxin-like potential that triggers the AhR-XRE pathway in vitro and in vivo.	Dioxins	86-92	aryl-hydrocarbon receptor	Mus musculus	126-129
16636061-0	2006	For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.	Dioxins	4-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	49-55
16636061-6	2006	To fetuses carried by Cyp1a2(-/-) dams, however, this dose of dioxin was lethal; this effect was absolutely dependent on the maternal Cyp1a2 genotype and independent of the embryonic Cyp1a2 genotype.	Dioxins	62-68	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	22-28
16636061-6	2006	To fetuses carried by Cyp1a2(-/-) dams, however, this dose of dioxin was lethal; this effect was absolutely dependent on the maternal Cyp1a2 genotype and independent of the embryonic Cyp1a2 genotype.	Dioxins	62-68	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	134-140
16636061-6	2006	To fetuses carried by Cyp1a2(-/-) dams, however, this dose of dioxin was lethal; this effect was absolutely dependent on the maternal Cyp1a2 genotype and independent of the embryonic Cyp1a2 genotype.	Dioxins	62-68	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	134-140
16636061-8	2006	More dioxin reached the embryos from Cyp1a2(-/-) dams, compared with that from Cyp1(+/+) dams.	Dioxins	5-11	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	37-43
16636061-8	2006	More dioxin reached the embryos from Cyp1a2(-/-) dams, compared with that from Cyp1(+/+) dams.	Dioxins	5-11	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	37-41
16636061-10	2006	Using the humanized hCYP1A1_1A2 transgenic mouse (expressing the human CYP1A1 and CYP1A2 genes in the absence of mouse Cyp1a2 gene), the teratogenic effects of dioxin reverted to the wild-type phenotype.	Dioxins	160-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
16636061-10	2006	Using the humanized hCYP1A1_1A2 transgenic mouse (expressing the human CYP1A1 and CYP1A2 genes in the absence of mouse Cyp1a2 gene), the teratogenic effects of dioxin reverted to the wild-type phenotype.	Dioxins	160-166	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	82-88
16636061-11	2006	These data indicate that maternal mouse hepatic CYP1A2, by sequestering dioxin and thus altering the pharmacokinetics, protects the embryos from toxicity and birth defects; substitution of the human CYP1A2 trans-gene provides the same protection.	Dioxins	72-78	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	48-54
16636061-11	2006	These data indicate that maternal mouse hepatic CYP1A2, by sequestering dioxin and thus altering the pharmacokinetics, protects the embryos from toxicity and birth defects; substitution of the human CYP1A2 trans-gene provides the same protection.	Dioxins	72-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	199-205
16545780-0	2006	Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	0-11
16545780-4	2006	The AhR is also recognized as the culprit for most toxic responses observed after exposure to dioxins and related compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	94-101	aryl hydrocarbon receptor	Homo sapiens	4-7
16442144-0	2006	Dioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.	Dioxins	11-17	pyruvate carboxylase	Homo sapiens	23-26
16442144-5	2006	From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands.	Dioxins	27-33	pyruvate carboxylase	Homo sapiens	39-42
16442144-5	2006	From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands.	Dioxins	82-88	pyruvate carboxylase	Homo sapiens	39-42
16442144-5	2006	From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands.	Dioxins	82-88	pyruvate carboxylase	Homo sapiens	94-97
16442144-6	2006	The long-term PCDD/F and dioxin-like PCB exposure of the infants was calculated using the statistical exposure model (STEM).	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	37-40
16955640-1	2006	"Dioxins" are used to specify polychlorinated dibenzo-p-dioxins (PCDD), dibenzo-furanes (F) and dioxin-like polychlorinated biphenyls (PCB"s).	Dioxins	1-8	pyruvate carboxylase	Homo sapiens	135-138
16756989-4	2006	Of the genes upregulated by U0126, four are classically induced through the aryl hydrocarbon receptor (AhR) by dioxins suggesting that U0126 activates the xenobiotic response element in cardiac myocytes potentially independently of effects on ERK1/2 signalling.	Dioxins	111-118	aryl hydrocarbon receptor	Rattus norvegicus	76-101
16756989-4	2006	Of the genes upregulated by U0126, four are classically induced through the aryl hydrocarbon receptor (AhR) by dioxins suggesting that U0126 activates the xenobiotic response element in cardiac myocytes potentially independently of effects on ERK1/2 signalling.	Dioxins	111-118	aryl hydrocarbon receptor	Rattus norvegicus	103-106
17160104-8	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
17160104-9	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
16687390-1	2006	Planar halogenated aromatic hydrocarbons (pHAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are potent inducers of cytochrome P4501A (CYP1A).	Dioxins	87-93	aryl hydrocarbon receptor 1a	Danio rerio	141-166
16687390-1	2006	Planar halogenated aromatic hydrocarbons (pHAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are potent inducers of cytochrome P4501A (CYP1A).	Dioxins	87-93	aryl hydrocarbon receptor 1a	Danio rerio	168-171
16687390-1	2006	Planar halogenated aromatic hydrocarbons (pHAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are potent inducers of cytochrome P4501A (CYP1A).	Dioxins	87-93	cytochrome P450, family 1, subfamily A	Danio rerio	200-217
16687390-1	2006	Planar halogenated aromatic hydrocarbons (pHAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are potent inducers of cytochrome P4501A (CYP1A).	Dioxins	87-93	cytochrome P450, family 1, subfamily A	Danio rerio	219-224
16687390-2	2006	It is widely accepted that dioxin toxicity is largely AHR mediated; however, the role of CYP1A activity in causing that toxicity is less clear.	Dioxins	27-33	aryl hydrocarbon receptor 1a	Danio rerio	54-57
16766111-0	2006	The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for dioxin exposure--effects in vital organs.	Dioxins	78-84	aryl-hydrocarbon receptor	Mus musculus	26-37
16766111-1	2006	The dioxin/aryl hydrocarbon receptor (AhR) mediates most, if not all, toxic effects of dioxins and functions as a ligand-activated transcription factor regulating transcription of a battery of genes.	Dioxins	87-94	aryl-hydrocarbon receptor	Mus musculus	4-36
16766111-1	2006	The dioxin/aryl hydrocarbon receptor (AhR) mediates most, if not all, toxic effects of dioxins and functions as a ligand-activated transcription factor regulating transcription of a battery of genes.	Dioxins	87-94	aryl-hydrocarbon receptor	Mus musculus	38-41
16766111-11	2006	In conclusion, this characterization further support that the CA-AhR mouse is a useful model for life-long continuous low-level activity of the AhR, i.e. the dioxin exposure situation of humans of the general population.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	65-68
16766111-11	2006	In conclusion, this characterization further support that the CA-AhR mouse is a useful model for life-long continuous low-level activity of the AhR, i.e. the dioxin exposure situation of humans of the general population.	Dioxins	158-164	aryl-hydrocarbon receptor	Mus musculus	144-147
16903077-5	2006	In addition, the biochanin A treatment alone activated the DNA-binding capacity of the AhR for the dioxin-response element (DRE) of CYP1A1, as measured by the electrophoretic-mobility shift assay (EMSA).	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	87-90
16903077-5	2006	In addition, the biochanin A treatment alone activated the DNA-binding capacity of the AhR for the dioxin-response element (DRE) of CYP1A1, as measured by the electrophoretic-mobility shift assay (EMSA).	Dioxins	99-105	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
16337987-5	2006	The medians of total non-dioxin-like PCB concentration were 1,835 and 1,033 ng g(-1) lipid in males and females, respectively.	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	37-40
16337987-11	2006	Congeners 153, 138(+163), 180 and 170(+190) were the main contributors to total non-dioxin-like PCB concentrations.	Dioxins	84-90	pyruvate carboxylase	Homo sapiens	96-99
16582008-1	2006	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important roles in metabolic adaptation, dioxin toxicology, and vascular development.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	4-29
16582008-1	2006	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important roles in metabolic adaptation, dioxin toxicology, and vascular development.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	31-34
16601081-2	2006	Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties.	Dioxins	219-225	aryl hydrocarbon receptor	Homo sapiens	109-134
16601081-2	2006	Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties.	Dioxins	219-225	aryl hydrocarbon receptor	Homo sapiens	136-139
16601081-12	2006	In addition, a chromatin immunoprecipitation assay further confirmed that BDE-99 could bind to the AhR and activate the AhR nuclear translocation and dioxin responsive element (DRE) binding in the context of the CYP1A1 promoter.	Dioxins	150-156	homeobox D13	Homo sapiens	74-77
16765953-0	2006	Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor -- dioxin responsive element signaling pathway.	Dioxins	83-89	aryl hydrocarbon receptor	Homo sapiens	54-79
16545771-1	2006	The aryl hydrocarbon receptor (AhR) is best known as a mediator of toxicity of a diverse family of xenobiotic chemicals such as dioxins and PCBs.	Dioxins	128-135	aryl-hydrocarbon receptor	Mus musculus	4-29
16545771-1	2006	The aryl hydrocarbon receptor (AhR) is best known as a mediator of toxicity of a diverse family of xenobiotic chemicals such as dioxins and PCBs.	Dioxins	128-135	aryl-hydrocarbon receptor	Mus musculus	31-34
16545771-14	2006	AhR in Hepa1c1c7 cell cytosol bound [(3)H]ITE with high affinity and the AhR.ITE complex formed in vitro bound dioxin response element (DRE) oligonucleotide as potently as TCDD.AhR.	Dioxins	111-117	aryl-hydrocarbon receptor	Mus musculus	0-3
16545771-14	2006	AhR in Hepa1c1c7 cell cytosol bound [(3)H]ITE with high affinity and the AhR.ITE complex formed in vitro bound dioxin response element (DRE) oligonucleotide as potently as TCDD.AhR.	Dioxins	111-117	aryl-hydrocarbon receptor	Mus musculus	73-76
16545771-14	2006	AhR in Hepa1c1c7 cell cytosol bound [(3)H]ITE with high affinity and the AhR.ITE complex formed in vitro bound dioxin response element (DRE) oligonucleotide as potently as TCDD.AhR.	Dioxins	111-117	aryl-hydrocarbon receptor	Mus musculus	73-76
16690800-3	2006	Of particular concern are findings that developmental exposure to dioxins, chemicals that act through the aryl hydrocarbon receptor pathway, permanently alters sexually differentiated neural functions in animal models.	Dioxins	66-73	aryl hydrocarbon receptor	Homo sapiens	106-131
18648615-0	2006	Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.	Dioxins	43-49	aryl hydrocarbon receptor	Homo sapiens	75-100
16758706-6	2006	In this study, mechanism-specific dioxin bioassays were used to study photolytic formation of AhR agonists in toluene solutions of decaBDE.	Dioxins	34-40	aryl hydrocarbon receptor 1 alpha	Gallus gallus	94-97
16758706-22	2006	AhR agonist effect in the recalcitrant fractions of the soils corresponded to the levels of chemically derived TEQs, based only on chlorinated dioxin-like compounds in an earlier study.	Dioxins	143-149	aryl hydrocarbon receptor 1 alpha	Gallus gallus	0-3
16467188-0	2006	Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus.	Dioxins	0-6	estrogen receptor 1 (alpha)	Mus musculus	33-50
16835634-2	2006	UNLABELLED: DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	TEF transcription factor, PAR bZIP family member	Homo sapiens	19-43
16835634-2	2006	UNLABELLED: DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl hydrocarbon receptor	Rattus norvegicus	242-267
16835634-2	2006	UNLABELLED: DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	12-18	aryl hydrocarbon receptor	Rattus norvegicus	269-272
16835634-3	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
16835634-7	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
16835634-8	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	177-180
16835634-14	2006	PCB 153 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs).	Dioxins	83-89	pyruvate carboxylase	Rattus norvegicus	0-3
16835634-15	2006	The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds.	Dioxins	4-10	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	11-14
16484282-6	2006	Specifically, Sim2s exerts a less repressive effect on hypoxia-induced gene expression than full-length Sim2, but is just as effective as Sim2 at repressing TCDD-induced gene expression from a dioxin response element.	Dioxins	193-199	single-minded family bHLH transcription factor 2	Mus musculus	14-18
16606854-0	2006	The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor.	Dioxins	37-43	aryl hydrocarbon receptor 1 alpha	Gallus gallus	78-103
16606854-8	2006	These studies provide a molecular understanding of species differences in sensitivity to dioxin-like compounds and suggest an approach to using the AHR as a marker of dioxin susceptibility in wildlife.	Dioxins	167-173	aryl hydrocarbon receptor 1 alpha	Gallus gallus	148-151
16839212-1	2006	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands.	Dioxins	147-154	aryl hydrocarbon receptor	Rattus norvegicus	4-29
16839212-1	2006	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands.	Dioxins	147-154	aryl hydrocarbon receptor	Rattus norvegicus	31-34
16517565-4	2006	The regulatory mechanisms of dioxin and estrogen in the expression of CXCR1/IL-8 in the corresponding cells will help in elucidating roles of the chemokine in the aetiology of endometriosis.	Dioxins	29-35	C-X-C motif chemokine receptor 1	Homo sapiens	70-75
16517565-4	2006	The regulatory mechanisms of dioxin and estrogen in the expression of CXCR1/IL-8 in the corresponding cells will help in elucidating roles of the chemokine in the aetiology of endometriosis.	Dioxins	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16391242-0	2006	Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling.	Dioxins	86-92	nuclear receptor interacting protein 1	Homo sapiens	40-45
16391242-0	2006	Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling.	Dioxins	86-92	nuclear receptor interacting protein 1	Homo sapiens	46-52
16835633-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
16835633-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
16835633-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
16835633-3	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
16835633-7	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
16835633-8	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	177-180
16835633-14	2006	The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds.	Dioxins	4-10	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	11-14
16835633-34	2006	CYTOCHROME P450 ENZYME ACTIVITIES: To evaluate the expression of known dioxin-responsive genes, CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activity were evaluated at 14, 31, and 53 weeks.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	96-102
16835633-34	2006	CYTOCHROME P450 ENZYME ACTIVITIES: To evaluate the expression of known dioxin-responsive genes, CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide-4-hydroxylase (A4H) activity were evaluated at 14, 31, and 53 weeks.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	165-171
16431846-0	2006	Dioxin exerts anti-estrogenic actions in a novel dioxin-responsive telomerase-immortalized epithelial cell line of the porcine oviduct (TERT-OPEC).	Dioxins	0-6	telomerase reverse transcriptase	Homo sapiens	136-140
16431846-0	2006	Dioxin exerts anti-estrogenic actions in a novel dioxin-responsive telomerase-immortalized epithelial cell line of the porcine oviduct (TERT-OPEC).	Dioxins	49-55	telomerase reverse transcriptase	Homo sapiens	136-140
16480812-10	2006	This ability of AhR to elicit spurious activation of retinoid receptors expands the scope of AhR ligands influence beyond ER antagonism and specific Dioxin-responsive genes.	Dioxins	149-155	aryl hydrocarbon receptor	Homo sapiens	93-96
16528449-4	2006	Silybin and dehydrosylibin inhibited basal and dioxin-inducible CYP1A1 catalytic activity in both cell lines used.	Dioxins	47-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
16613807-0	2006	Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	26-51
16613807-0	2006	Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	53-56
16613807-0	2006	Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.	Dioxins	18-24	aryl hydrocarbon receptor	Homo sapiens	160-163
16451855-2	2006	In a 2002-2003 WHO exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 PCDD/F and dioxin-like PCB congeners.	Dioxins	198-204	pyruvate carboxylase	Homo sapiens	210-213
16115717-0	2006	Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins.	Dioxins	112-119	aryl hydrocarbon receptor	Homo sapiens	75-100
16115717-1	2006	Dioxins enter the body mainly through diet and cause the various toxicological effects by binding to the cytosolic aryl hydrocarbon receptor (AhR) followed by its transformation.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	115-140
16115717-1	2006	Dioxins enter the body mainly through diet and cause the various toxicological effects by binding to the cytosolic aryl hydrocarbon receptor (AhR) followed by its transformation.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	142-145
16187124-6	2006	RESULTS: The lymphocytic 8-OH-dG level showed a negative association with the serum dioxin level (total value of TEQ-PCDD, PCDF, and Co-PCB).	Dioxins	84-90	pyruvate carboxylase	Homo sapiens	136-139
16407087-5	2006	Data suggest that GPT activity levels may be modified by interaction of CYP1A1/Msp 1 genotype with dioxin after adjustment for age, alcohol consumption, and history of liver illness.	Dioxins	99-105	glutamic--pyruvic transaminase	Homo sapiens	18-21
16407087-5	2006	Data suggest that GPT activity levels may be modified by interaction of CYP1A1/Msp 1 genotype with dioxin after adjustment for age, alcohol consumption, and history of liver illness.	Dioxins	99-105	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
16291824-10	2006	Although dioxin in utero is well known to cause AHR-dependent cleft palate and hydronephrosis, cHBB did not; thus, chronic activation of the AHR appears to be necessary but not sufficient for AHR-mediated teratogenicity.	Dioxins	9-15	aryl-hydrocarbon receptor	Mus musculus	48-51
16291824-10	2006	Although dioxin in utero is well known to cause AHR-dependent cleft palate and hydronephrosis, cHBB did not; thus, chronic activation of the AHR appears to be necessary but not sufficient for AHR-mediated teratogenicity.	Dioxins	9-15	aryl-hydrocarbon receptor	Mus musculus	141-144
16291824-10	2006	Although dioxin in utero is well known to cause AHR-dependent cleft palate and hydronephrosis, cHBB did not; thus, chronic activation of the AHR appears to be necessary but not sufficient for AHR-mediated teratogenicity.	Dioxins	9-15	aryl-hydrocarbon receptor	Mus musculus	141-144
16291828-1	2006	The Ah receptor (AhR) is a ligand transcription factor mediating toxic effects of chemicals such as dioxins.	Dioxins	100-107	aryl hydrocarbon receptor	Homo sapiens	4-15
16291828-1	2006	The Ah receptor (AhR) is a ligand transcription factor mediating toxic effects of chemicals such as dioxins.	Dioxins	100-107	aryl hydrocarbon receptor	Homo sapiens	17-20
16291828-3	2006	In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model.	Dioxins	84-90	aryl hydrocarbon receptor	Homo sapiens	120-123
16291828-3	2006	In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model.	Dioxins	84-90	thyroid peroxidase	Homo sapiens	273-276
16291828-3	2006	In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model.	Dioxins	84-90	thyroid stimulating hormone receptor	Homo sapiens	314-326
16291828-3	2006	In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model.	Dioxins	84-90	thyroid stimulating hormone receptor	Homo sapiens	328-332
16233944-1	2006	Exposure to polychlorinated biphenyls (PCBs) is known to suppress immune system function and this action is usually ascribed to dioxin-like PCBs that act via the Ah receptor.	Dioxins	128-134	aryl-hydrocarbon receptor	Mus musculus	162-173
16233944-8	2006	These observations are consistent with previous results that suggest that ortho-substituted PCB congeners dissolve in cell membrane and cause greater disruption of function than do dioxin-like PCB congeners.	Dioxins	181-187	pyruvate carboxylase	Mus musculus	193-196
16214954-0	2006	Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries.	Dioxins	45-51	aryl-hydrocarbon receptor	Mus musculus	0-25
16214954-0	2006	Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries.	Dioxins	66-72	aryl-hydrocarbon receptor	Mus musculus	0-25
16214954-6	2006	In Ahr(-/-) mice, only 32 ProbeSets exhibited responses to TCDD, indicating that the AHR is required for virtually all transcriptional responses to dioxin exposure in liver.	Dioxins	148-154	aryl-hydrocarbon receptor	Mus musculus	85-88
16628245-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	TEF transcription factor, PAR bZIP family member	Homo sapiens	7-31
16414014-0	2006	Osteopontin: a rapid and sensitive response to dioxin exposure in the osteoblastic cell line UMR-106.	Dioxins	47-53	secreted phosphoprotein 1	Homo sapiens	0-11
16414014-2	2006	TCDD modulates the transcription of various genes, e.g., CYP1A1, and the present study is a part of a project aiming at developing an in vitro model system for identifying biomarkers specific for dioxin-induced effects in osteoblasts.	Dioxins	196-202	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-63
16628245-15	2006	The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds.	Dioxins	4-10	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	11-14
16628245-16	2006	PCB 126 was included since this is the most potent coplanar PCB that has dioxin-like activities.	Dioxins	73-79	pyruvate carboxylase	Rattus norvegicus	0-3
16628245-16	2006	PCB 126 was included since this is the most potent coplanar PCB that has dioxin-like activities.	Dioxins	73-79	pyruvate carboxylase	Rattus norvegicus	60-63
16628245-36	2006	CYTOCHROME P450 ENZYME ACTIVITIES: To evaluate the expression of known dioxin-responsive genes, CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide 4-hydroxylase (A-4-H) activity were evaluated at the 14-, 31-, and 53-week interim evaluations.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	96-102
16628245-36	2006	CYTOCHROME P450 ENZYME ACTIVITIES: To evaluate the expression of known dioxin-responsive genes, CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and CYP1A2-associated acetanilide 4-hydroxylase (A-4-H) activity were evaluated at the 14-, 31-, and 53-week interim evaluations.	Dioxins	71-77	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	165-171
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	328-352
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	354-357
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-80	aryl hydrocarbon receptor	Homo sapiens	372-375
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	328-352
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	354-357
16506649-3	2006	In this review, I have summarized and discussed the unique toxicities of dioxins and related compounds on the basis of our own experimental studies as well as those of others in the following four aspects: (1) endpoints at a low dioxin dose, (2) critical sensitivity window to dioxin exposure and disruption of homeostasis, (3) arylhydrocarbon receptor (AhR)-mediated and AhR-independent toxicities and (4) differences in susceptibility between humans and rodents, and that between strains of identical species.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	372-375
16506651-6	2006	Only a few Dutch studies have suggested that perinatal exposure to background level of PCB/dioxin confers immunity to allergy development.	Dioxins	91-97	pyruvate carboxylase	Homo sapiens	87-90
16862222-2	2006	AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds.	Dioxins	79-85	aryl hydrocarbon receptor	Homo sapiens	0-3
16862222-5	2006	Here we will discuss recent data revealing that dioxin bound AhR recruits ERalpha to AhR regulated genes.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	61-64
16862222-5	2006	Here we will discuss recent data revealing that dioxin bound AhR recruits ERalpha to AhR regulated genes.	Dioxins	48-54	estrogen receptor 1	Homo sapiens	74-81
16862222-5	2006	Here we will discuss recent data revealing that dioxin bound AhR recruits ERalpha to AhR regulated genes.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	85-88
16120753-1	2006	The toxic equivalency factor (TEF) approach has been widely accepted as the most feasible method available at present for evaluating potential health risks associated with exposure to mixtures of dioxin-like compounds (DLCs).	Dioxins	196-202	TEF transcription factor, PAR bZIP family member	Homo sapiens	4-28
16120753-1	2006	The toxic equivalency factor (TEF) approach has been widely accepted as the most feasible method available at present for evaluating potential health risks associated with exposure to mixtures of dioxin-like compounds (DLCs).	Dioxins	196-202	TEF transcription factor, PAR bZIP family member	Homo sapiens	30-33
16192470-7	2006	The promoter region of epiregulin has a dioxin responsive element (DRE) 56 nucleotides upstream of the transcription start site, along with three potential Sp1 binding sites.	Dioxins	40-46	epiregulin	Rattus norvegicus	23-33
20021027-1	2006	Endocrine systems of humans and animals are disturbed by dioxin-like compounds, which are ligands of the aryl hydrocarbon receptor (AhR).	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	132-135
18516253-5	2006	Our experiments show that in human, non-human primate, rat, trout, and zebrafish ovarian tissues, dioxin inhibits estrogen synthesis at some level of the steroid biosynthetic pathway, most likely by inhibiting transcription of mRNAs for or activity of side-chain cleavage (Cyp11a1 gene) and/or aromatase (Cyp19a1 gene) enzymes, or conceivably other steroidogenic enzymes/factors.	Dioxins	98-104	cytochrome P450, family 11, subfamily A, polypeptide 1	Danio rerio	273-280
18516253-5	2006	Our experiments show that in human, non-human primate, rat, trout, and zebrafish ovarian tissues, dioxin inhibits estrogen synthesis at some level of the steroid biosynthetic pathway, most likely by inhibiting transcription of mRNAs for or activity of side-chain cleavage (Cyp11a1 gene) and/or aromatase (Cyp19a1 gene) enzymes, or conceivably other steroidogenic enzymes/factors.	Dioxins	98-104	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	305-312
20021027-1	2006	Endocrine systems of humans and animals are disturbed by dioxin-like compounds, which are ligands of the aryl hydrocarbon receptor (AhR).	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	105-130
16054781-0	2005	Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.	Dioxins	102-108	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	8-14
16054781-0	2005	Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.	Dioxins	102-108	DNL-type zinc finger	Homo sapiens	93-98
16366731-1	2005	Suppressive effects of ethanolic extracts prepared from propolis group 12 and its main botanical origin (leaf bud of Baccharis dracunculifolia) on transformation of the aryl hydrocarbon receptor (AhR), the initial action of dioxin toxicity, were investigated.	Dioxins	224-230	aryl-hydrocarbon receptor	Mus musculus	196-199
16137648-7	2005	The consequences are very different from those of AHR nuclear translocation mediated by the classical ligands (enzyme inducers such as dioxin) and are likely to represent the long-sought physiological function of the AHR, its persistent disturbance by long-lived ligands such as dioxin may well be the reason for its high toxicity.	Dioxins	135-141	aryl hydrocarbon receptor	Homo sapiens	50-53
16137648-7	2005	The consequences are very different from those of AHR nuclear translocation mediated by the classical ligands (enzyme inducers such as dioxin) and are likely to represent the long-sought physiological function of the AHR, its persistent disturbance by long-lived ligands such as dioxin may well be the reason for its high toxicity.	Dioxins	135-141	aryl hydrocarbon receptor	Homo sapiens	217-220
16137648-7	2005	The consequences are very different from those of AHR nuclear translocation mediated by the classical ligands (enzyme inducers such as dioxin) and are likely to represent the long-sought physiological function of the AHR, its persistent disturbance by long-lived ligands such as dioxin may well be the reason for its high toxicity.	Dioxins	279-285	aryl hydrocarbon receptor	Homo sapiens	217-220
16301529-1	2005	The aryl hydrocarbon receptor (AHR) plays a role in three areas of biology that include the adaptive metabolism of xenobiotics, the toxic responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), and vascular remodeling of the developing embryo.	Dioxins	205-211	aryl hydrocarbon receptor	Homo sapiens	4-29
16301529-1	2005	The aryl hydrocarbon receptor (AHR) plays a role in three areas of biology that include the adaptive metabolism of xenobiotics, the toxic responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), and vascular remodeling of the developing embryo.	Dioxins	205-211	aryl hydrocarbon receptor	Homo sapiens	31-34
16301529-4	2005	Using this model, we provide evidence that AHR signaling in endothelial/hematopoietic cells is necessary for developmental closure of the ductus venosus, whereas AHR signaling in hepatocytes is necessary to generate adaptive and toxic responses of the liver in response to dioxin exposure.	Dioxins	273-279	aryl hydrocarbon receptor	Homo sapiens	43-46
16628245-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	230-255
16628245-2	2006	DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW: Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	257-260
16628245-3	2006	Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs).	Dioxins	128-134	aryl hydrocarbon receptor	Rattus norvegicus	48-51
16628245-7	2006	The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD that is the most potent congener.	Dioxins	64-70	TEF transcription factor, PAR bZIP family member	Rattus norvegicus	4-7
16263690-3	2005	Direct causal relationship between PCB and dioxin exposure and the observed detrimental effects on the immune system has yet to be fully established in humans.	Dioxins	43-49	pyruvate carboxylase	Homo sapiens	35-38
16263525-0	2005	In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns.	Dioxins	21-28	growth hormone 1	Homo sapiens	101-115
16552988-17	2005	Differences in AhR-responsiveness of granulosa and theca cells to TCDD and dioxin-like PCB 126 are probably connected with the differences of these cells in estradiol secretion and different proliferative potential.	Dioxins	75-81	aryl hydrocarbon receptor	Sus scrofa	15-18
16126234-1	2005	The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay.	Dioxins	177-183	aryl hydrocarbon receptor	Homo sapiens	13-38
16126234-5	2005	It is recommended that further work be performed to characterise the full range of stable dioxin like AhR agonists present in offshore produced water discharges using techniques such as bioassay-directed analysis.	Dioxins	90-96	aryl hydrocarbon receptor	Homo sapiens	102-105
16107549-3	2005	The present work has investigated the effects of individual components of a commercial PBDE mixture (DE71) on expression of CYP1A1, a biomarker for activation of the AhR (dioxin-like), and CYP2B and CYP3A, biomarkers for activation of the constitutive androstane and pregnanexreceptors (CAR and PXR), respectively, in the rat.	Dioxins	171-177	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	124-130
16107549-6	2005	Quantitative PCR analysis indicated up-regulation of CYP1A1 by DE71; however, the response was weak compared to that for dioxin-like PCB126.	Dioxins	121-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	53-59
16107549-8	2005	Representative PBDFs efficiently up-regulated CYP1A1; therefore, they, along with other PBDFs and polybrominated dibenzodioxins detected in DE71 and individual PBDE components, may be responsible for most, if not all, dioxin-like properties previously observed for PBDEs.	Dioxins	120-126	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	46-52
16182859-12	2005	Seven PCB congeners, (PCB 180, 153, 138, 170, 194, 118, and 156), including those at higher chlorination, were present in more than 30% of the subjects and contributed 99% of the total PCB levels, with a modest role of dioxin-like congeners.	Dioxins	219-225	pyruvate carboxylase	Homo sapiens	6-9
16054739-1	2005	Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which mediates most, if not all, of the toxic responses of these agents.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	75-100
16054739-1	2005	Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which mediates most, if not all, of the toxic responses of these agents.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	102-105
16054739-1	2005	Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which mediates most, if not all, of the toxic responses of these agents.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	75-100
16054739-1	2005	Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which mediates most, if not all, of the toxic responses of these agents.	Dioxins	12-18	aryl hydrocarbon receptor	Homo sapiens	102-105
16054739-2	2005	Since dioxins are not directly genotoxic their carcinogenic effect is likely the result of their tumor promoting activity produced by activation of the AhR.	Dioxins	6-13	aryl hydrocarbon receptor	Homo sapiens	152-155
16054739-7	2005	Dioxins may act in concert with endogenous ligands of the AhR, an effect which becomes particularly relevant at low toxicant concentrations.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	58-61
16046213-3	2005	Here we provide evidence that berberine activates the aryl hydrocarbon receptor (AhR) in human hepatoma (HepG2) and rat hepatoma cells stably transfected with a dioxin responsive element fused to the luciferase gene (H4IIE.luc).	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	54-79
16046213-3	2005	Here we provide evidence that berberine activates the aryl hydrocarbon receptor (AhR) in human hepatoma (HepG2) and rat hepatoma cells stably transfected with a dioxin responsive element fused to the luciferase gene (H4IIE.luc).	Dioxins	161-167	aryl hydrocarbon receptor	Homo sapiens	81-84
16628245-8	2006	This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.	Dioxins	48-54	aryl hydrocarbon receptor	Rattus norvegicus	178-181
16628245-14	2006	PCB 126 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs.	Dioxins	83-89	pyruvate carboxylase	Rattus norvegicus	0-3
15993909-5	2005	The aryl hydrocarbon receptor (AHR) mediates toxicity of dioxin-like compounds.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	4-29
15993909-5	2005	The aryl hydrocarbon receptor (AHR) mediates toxicity of dioxin-like compounds.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	31-34
16054184-6	2005	CYP2S1 is inducible by dioxin, the induction being mediated by the Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in a manner typical for CYP1 family members.	Dioxins	23-29	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	0-6
16054184-6	2005	CYP2S1 is inducible by dioxin, the induction being mediated by the Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in a manner typical for CYP1 family members.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	67-92
16054184-6	2005	CYP2S1 is inducible by dioxin, the induction being mediated by the Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in a manner typical for CYP1 family members.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	94-97
16054184-6	2005	CYP2S1 is inducible by dioxin, the induction being mediated by the Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in a manner typical for CYP1 family members.	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	103-140
16054184-6	2005	CYP2S1 is inducible by dioxin, the induction being mediated by the Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in a manner typical for CYP1 family members.	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	142-146
16115918-1	2005	PURPOSE: Cytochrome P450 1B1 (CYP1B1), a dioxin inducible member of the CYP supergene family, is overexpressed in various human malignancies including prostate cancer.	Dioxins	41-47	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	9-28
16115918-1	2005	PURPOSE: Cytochrome P450 1B1 (CYP1B1), a dioxin inducible member of the CYP supergene family, is overexpressed in various human malignancies including prostate cancer.	Dioxins	41-47	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	30-36
16115918-5	2005	MSP primers covered dioxin response elements (DRE) and Sp1 sites that are important for the expression of CYP1B1.	Dioxins	20-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-112
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	43-68
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	70-73
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	186-189
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	161-168	aryl hydrocarbon receptor	Homo sapiens	43-68
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	161-168	aryl hydrocarbon receptor	Homo sapiens	70-73
15913656-2	2005	Dioxins bind specifically to the cytosolic aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, and a majority of toxic effects of dioxins are mediated via AHR.	Dioxins	161-168	aryl hydrocarbon receptor	Homo sapiens	186-189
16084869-6	2005	MAIN OUTCOME MEASURE(S): Assessment of dioxin (PCDD), furan (PCDF), and dioxin-like PCB serum concentrations (picograms toxic equivalent [TEQ]/g lipids).	Dioxins	72-78	pyruvate carboxylase	Homo sapiens	84-87
16047776-3	2005	Especially, certain dioxin-like coplanar PCB congeners (Co-PCBs), such as CB-77 and CB-105, whose source is commercial PCBs,were significantly higher in crows from the dumping site than those from the reference sites.	Dioxins	20-26	pyruvate carboxylase	Homo sapiens	41-44
15837795-0	2005	ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription.	Dioxins	94-100	estrogen receptor 1	Homo sapiens	0-8
15837795-0	2005	ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription.	Dioxins	94-100	aryl hydrocarbon receptor	Homo sapiens	9-12
15837795-0	2005	ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription.	Dioxins	94-100	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	13-17
15930751-2	2005	CAIII gene which is highly suppressible by dioxins in vivo, was also suppressible in primary cultured hepatocytes of rats by an AhR ligand, 3-methylchlanthrene (3MC).	Dioxins	43-50	carbonic anhydrase 3	Rattus norvegicus	0-5
15930751-2	2005	CAIII gene which is highly suppressible by dioxins in vivo, was also suppressible in primary cultured hepatocytes of rats by an AhR ligand, 3-methylchlanthrene (3MC).	Dioxins	43-50	aryl hydrocarbon receptor	Rattus norvegicus	128-131
15746008-14	2005	The dioxin-resistance alleles, Ahr(hw) and B(hw) increase the resistance to these defects.	Dioxins	4-10	aryl hydrocarbon receptor	Rattus norvegicus	35-37
15857604-3	2005	Use of persistent agonists such as dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds demonstrated that the AhR mediates a plethora of species- and tissue-dependent toxicities, including chloracne, wasting, teratogenicity, immunotoxicity, liver tumor promotion and carcinogenicity.	Dioxins	35-42	aryl-hydrocarbon receptor	Mus musculus	140-143
15965093-0	2005	Bcl-2 gene family expression in the brain of rat offspring after gestational and lactational dioxin exposure.	Dioxins	93-99	BCL2, apoptosis regulator	Rattus norvegicus	0-5
15965093-3	2005	The expressions of dioxin-responsive gene cytochrome P450 1A1 (CYP1A1), apoptotic gene Bax, and anti-apoptotic genes Bcl-2 and Bcl-xL were examined in rat liver and brains using Western blot analysis and RT-PCR.	Dioxins	19-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	42-61
15965093-10	2005	These results indicate that early exposure of dioxin could affect the development of certain brain regions with gender difference, in terms of its differential effect on expressions of Bcl-xL, Bcl-2, and Bax.	Dioxins	46-52	Bcl2-like 1	Rattus norvegicus	185-191
15965093-10	2005	These results indicate that early exposure of dioxin could affect the development of certain brain regions with gender difference, in terms of its differential effect on expressions of Bcl-xL, Bcl-2, and Bax.	Dioxins	46-52	BCL2, apoptosis regulator	Rattus norvegicus	193-198
15965093-10	2005	These results indicate that early exposure of dioxin could affect the development of certain brain regions with gender difference, in terms of its differential effect on expressions of Bcl-xL, Bcl-2, and Bax.	Dioxins	46-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	204-207
15870332-1	2005	Mass spectrometry is a potentially attractive means of monitoring the survival and efficacy of bioaugmentation agents, such as the dioxin-mineralizing bacterium Sphingomonas wittichii strain RW1.	Dioxins	131-137	transmembrane protein 131	Mus musculus	191-194
15886252-2	2005	OBJECTIVE: The aim of the present study was to examine the effect of dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)] on GdA production in human endometrial cells.	Dioxins	69-75	guanine deaminase	Homo sapiens	124-127
15886252-9	2005	Because the action of dioxin is mediated by the aryl hydrocarbon receptor (AhR), we ascertained that primary epithelial and Ishikawa cells express AhR.	Dioxins	22-28	aryl hydrocarbon receptor	Homo sapiens	48-73
15886252-9	2005	Because the action of dioxin is mediated by the aryl hydrocarbon receptor (AhR), we ascertained that primary epithelial and Ishikawa cells express AhR.	Dioxins	22-28	aryl hydrocarbon receptor	Homo sapiens	75-78
15886252-9	2005	Because the action of dioxin is mediated by the aryl hydrocarbon receptor (AhR), we ascertained that primary epithelial and Ishikawa cells express AhR.	Dioxins	22-28	aryl hydrocarbon receptor	Homo sapiens	147-150
15886252-12	2005	CONCLUSIONS: We demonstrated a direct AhR-mediated effect of dioxin on GdA gene transcription and protein secretion that might influence human female fertility.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	38-41
15886252-12	2005	CONCLUSIONS: We demonstrated a direct AhR-mediated effect of dioxin on GdA gene transcription and protein secretion that might influence human female fertility.	Dioxins	61-67	guanine deaminase	Homo sapiens	71-74
15897893-1	2005	The aryl hydrocarbon receptor (AhR) has a fundamental role during postnatal liver development and is essential for mediating dioxin toxicity.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	4-29
15897893-1	2005	The aryl hydrocarbon receptor (AhR) has a fundamental role during postnatal liver development and is essential for mediating dioxin toxicity.	Dioxins	125-131	aryl hydrocarbon receptor	Homo sapiens	31-34
15897893-7	2005	Furthermore, increased p38-MAPK phosphorylation in response to dioxins does not require ongoing transcription.	Dioxins	63-70	mitogen-activated protein kinase 14	Homo sapiens	23-26
15897893-7	2005	Furthermore, increased p38-MAPK phosphorylation in response to dioxins does not require ongoing transcription.	Dioxins	63-70	mitogen-activated protein kinase 14	Homo sapiens	27-31
16051526-1	2005	Expression of cytochrome P4501A (CYP1A) has been used as a biomarker for possible exposure to contaminants such as PCBs and dioxins in teleost fish.	Dioxins	124-131	cytochrome P450, family 1, subfamily A	Salmo salar	33-38
15964790-0	2005	Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.	Dioxins	138-144	aryl hydrocarbon receptor	Homo sapiens	0-25
15964790-0	2005	Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.	Dioxins	138-144	estrogen receptor 1	Homo sapiens	82-105
15900503-0	2005	Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	54-79
15900503-7	2005	Essential steps in this adaptive mechanism include AhR binding of ligand in the cytoplasm of cells associated with two molecules of chaperone heatshock protein (Hsp90) and AhR interactive protein, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor (present in CYP1A) to dioxin-responsive elements upstream of promoters that regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	376-382	aryl hydrocarbon receptor	Homo sapiens	51-54
15900503-7	2005	Essential steps in this adaptive mechanism include AhR binding of ligand in the cytoplasm of cells associated with two molecules of chaperone heatshock protein (Hsp90) and AhR interactive protein, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor (present in CYP1A) to dioxin-responsive elements upstream of promoters that regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	376-382	heat shock protein 90 alpha family class A member 1	Homo sapiens	161-166
15872048-1	2005	CYP2S1 is a recently discovered dioxin-inducible member of the cytochrome P450 superfamily.	Dioxins	32-38	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	0-6
15681594-1	2005	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins.	Dioxins	247-254	aryl hydrocarbon receptor	Homo sapiens	4-29
15681594-1	2005	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins.	Dioxins	247-254	aryl hydrocarbon receptor	Homo sapiens	31-34
15722456-0	2005	Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines.	Dioxins	11-17	interleukin 1 complex	Mus musculus	43-56
15722456-2	2005	Most, if not all, of these responses are dependent upon the binding of dioxin to the aryl hydrocarbon receptor.	Dioxins	71-77	aryl-hydrocarbon receptor	Mus musculus	85-110
15722456-3	2005	Given their common roles in chemically induced toxicity, we asked whether interleukin 1 (IL1)-like cytokines play a role in acute aspects of the dioxin response.	Dioxins	145-151	interleukin 1 complex	Mus musculus	74-92
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-157	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-157	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-157	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-44
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-156	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-156	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
15659568-1	2005	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds.	Dioxins	150-156	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-44
15659568-11	2005	In addition, dioxin concentrations at which effects were observed in our in vitro study are about 10-fold higher than the human blood levels found in vivo, indicating that EROD activity and CYP1A1 and CYP1B1 expression in human lymphocytes might not be applicable as biomarkers of exposure to dioxin and dioxin-like compounds.	Dioxins	13-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	190-196
15659568-11	2005	In addition, dioxin concentrations at which effects were observed in our in vitro study are about 10-fold higher than the human blood levels found in vivo, indicating that EROD activity and CYP1A1 and CYP1B1 expression in human lymphocytes might not be applicable as biomarkers of exposure to dioxin and dioxin-like compounds.	Dioxins	13-19	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	201-207
15716480-6	2005	The cholecystokinin-A receptor (CCK-A receptor; CCKAR) and duodenal cholecystokinin 8 (CCK) revealed the associations of dioxin treatment with hormonal changes.	Dioxins	121-127	cholecystokinin A receptor	Rattus norvegicus	4-30
15716480-6	2005	The cholecystokinin-A receptor (CCK-A receptor; CCKAR) and duodenal cholecystokinin 8 (CCK) revealed the associations of dioxin treatment with hormonal changes.	Dioxins	121-127	cholecystokinin	Rattus norvegicus	68-85
15716480-6	2005	The cholecystokinin-A receptor (CCK-A receptor; CCKAR) and duodenal cholecystokinin 8 (CCK) revealed the associations of dioxin treatment with hormonal changes.	Dioxins	121-127	cholecystokinin	Rattus norvegicus	32-35
15655410-2	2005	Ligands for the AhR (i.e. dioxin) have also been shown to modulate the NF-kappaB signaling cascade, affecting physiological processes such as cellular immunity, inflammation, proliferation and survival.	Dioxins	26-32	aryl hydrocarbon receptor	Homo sapiens	16-19
15972329-0	2005	Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.	Dioxins	49-55	aryl hydrocarbon receptor	Homo sapiens	0-25
15972329-6	2005	Here, we show that the second messenger, cAMP (an endogenous mediator of hormones, neurotransmitters, and prostaglandins), activates the AHR, moving the receptor to the nucleus in some ways that are similar to and in other ways fundamentally different from AHR activation by dioxin.	Dioxins	275-281	aryl hydrocarbon receptor	Homo sapiens	137-140
15972329-7	2005	We suggest that this cAMP-mediated activation may reflect the true endogenous function of AHR; disruption of the cAMP-mediated activation by dioxin, binding chronically to the AHR for days, weeks, or months, might be pivotal in the mechanism of dioxin toxicity.	Dioxins	141-147	aryl hydrocarbon receptor	Homo sapiens	90-93
15972329-7	2005	We suggest that this cAMP-mediated activation may reflect the true endogenous function of AHR; disruption of the cAMP-mediated activation by dioxin, binding chronically to the AHR for days, weeks, or months, might be pivotal in the mechanism of dioxin toxicity.	Dioxins	141-147	aryl hydrocarbon receptor	Homo sapiens	176-179
15972329-7	2005	We suggest that this cAMP-mediated activation may reflect the true endogenous function of AHR; disruption of the cAMP-mediated activation by dioxin, binding chronically to the AHR for days, weeks, or months, might be pivotal in the mechanism of dioxin toxicity.	Dioxins	245-251	aryl hydrocarbon receptor	Homo sapiens	90-93
15972329-7	2005	We suggest that this cAMP-mediated activation may reflect the true endogenous function of AHR; disruption of the cAMP-mediated activation by dioxin, binding chronically to the AHR for days, weeks, or months, might be pivotal in the mechanism of dioxin toxicity.	Dioxins	245-251	aryl hydrocarbon receptor	Homo sapiens	176-179
15856391-0	2005	[Human biomonitoring investigations of organochlorine compounds -- PCB, DDE, HCB, beta- and gamma-HCH, PCDD/PCDF, Dioxin-like PCB"s and polybrominated biphenyl ethers].	Dioxins	114-120	pyruvate carboxylase	Homo sapiens	126-129
15668235-5	2005	We found that that the addition of TGFbeta3 to an in vitro palate culture model prevented the dioxin-induced reduction in filopodial density.	Dioxins	94-100	transforming growth factor, beta 3	Mus musculus	35-43
15668235-6	2005	Moreover, TGFbeta3 exposure completely prevented the dioxin-induced block of palatal fusion in this system.	Dioxins	53-59	transforming growth factor, beta 3	Mus musculus	10-18
15668235-7	2005	Although these data do not point to a direct cellular or molecular mechanism for TGFbeta3 dioxin antagonism, these results do suggest that TGFbeta3 or stimulators of this signaling pathway hold potential as antidotes for dioxin-induced terata and that this opposing pharmacology may extend to additional toxicological endpoints.	Dioxins	221-227	transforming growth factor, beta 3	Mus musculus	139-147
15659567-0	2005	Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals.	Dioxins	47-53	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	28-34
15914907-1	2005	Dioxins induce adverse effects through transformation of the cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	71-96
15914907-1	2005	Dioxins induce adverse effects through transformation of the cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	98-101
15659567-2	2005	The induction of CYP1A2 activity has been used as a noninvasive biomarker for human exposure to dioxins; while there is a consistent relationship between exposure and hepatic CYP1A2 induction in rodents, this relationship has only been observed in some of the highest exposed human populations.	Dioxins	96-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	175-181
15659567-3	2005	This may be explained by inhibition of CYP1A2 activity by dioxins as some rodent studies demonstrate that rodent CYP1A2 activity can in fact be inhibited by dioxins in vitro.	Dioxins	58-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
15659567-3	2005	This may be explained by inhibition of CYP1A2 activity by dioxins as some rodent studies demonstrate that rodent CYP1A2 activity can in fact be inhibited by dioxins in vitro.	Dioxins	58-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	113-119
15659567-3	2005	This may be explained by inhibition of CYP1A2 activity by dioxins as some rodent studies demonstrate that rodent CYP1A2 activity can in fact be inhibited by dioxins in vitro.	Dioxins	157-164	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
15659567-3	2005	This may be explained by inhibition of CYP1A2 activity by dioxins as some rodent studies demonstrate that rodent CYP1A2 activity can in fact be inhibited by dioxins in vitro.	Dioxins	157-164	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	113-119
15659567-4	2005	CYP1A2 activity was examined using a series of dioxins to inhibit human and rat CYP1A2 activity in species-specific CYP1A2 SUPERSOMES using three common CYP1A2 substrates.	Dioxins	47-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
15659567-4	2005	CYP1A2 activity was examined using a series of dioxins to inhibit human and rat CYP1A2 activity in species-specific CYP1A2 SUPERSOMES using three common CYP1A2 substrates.	Dioxins	47-54	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-86
15659567-4	2005	CYP1A2 activity was examined using a series of dioxins to inhibit human and rat CYP1A2 activity in species-specific CYP1A2 SUPERSOMES using three common CYP1A2 substrates.	Dioxins	47-54	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-86
15659567-4	2005	CYP1A2 activity was examined using a series of dioxins to inhibit human and rat CYP1A2 activity in species-specific CYP1A2 SUPERSOMES using three common CYP1A2 substrates.	Dioxins	47-54	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-86
15659567-7	2005	These data demonstrate that the in vitro metabolism of prototype substrates is similar between the rat and human CYP1A2 SUPERSOME preparations and that dioxins inhibit CYP1A2 activity in both species.	Dioxins	152-159	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	168-174
15659567-8	2005	Because of the potential for inhibition of CYP1A2 activity by TCDD and other dioxins, studies examining CYP1A2 induction in dioxin-exposed populations using these substrates should be viewed cautiously.	Dioxins	77-84	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
15659567-8	2005	Because of the potential for inhibition of CYP1A2 activity by TCDD and other dioxins, studies examining CYP1A2 induction in dioxin-exposed populations using these substrates should be viewed cautiously.	Dioxins	77-83	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
15792794-4	2005	Dioxin, a contaminant activating the aryl hydrocarbon receptor (AhR) like PAHs, was also shown to increase TNFalpha expression.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	37-62
15792794-4	2005	Dioxin, a contaminant activating the aryl hydrocarbon receptor (AhR) like PAHs, was also shown to increase TNFalpha expression.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	64-67
15792794-4	2005	Dioxin, a contaminant activating the aryl hydrocarbon receptor (AhR) like PAHs, was also shown to increase TNFalpha expression.	Dioxins	0-6	tumor necrosis factor	Homo sapiens	107-115
15868926-1	2005	BACKGROUND: The dioxin/Aryl hydrocarbon (Ah) receptor is a ligand-activated transcription factor known to mediate the toxic effects of the environmental pollutants dioxins.	Dioxins	164-171	aryl-hydrocarbon receptor	Mus musculus	16-53
15667840-9	2005	The pattern of non-ortho and mono-ortho PCBs in the blood of children was similar to the pattern reported for mother"s milk, and PCB 126 and PCB 156 contributed about 70% to the toxicity of dioxin-like PCBs and about one-third to total TEQ including PCDD/PCDFs.	Dioxins	190-196	pyruvate carboxylase	Homo sapiens	129-132
15728486-3	2005	Thymocyte development and T cell-dependent immune reactions are sensitive targets of AhR-dependent 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity.	Dioxins	128-134	aryl-hydrocarbon receptor	Mus musculus	85-88
15664268-0	2005	Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.	Dioxins	73-79	aldehyde oxidase 1	Mus musculus	18-36
15664268-0	2005	Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.	Dioxins	73-79	aldehyde oxidase 3	Mus musculus	41-69
15664268-2	2005	We have identified aldehyde oxidase 1 (AOX1) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) inducible gene in the mouse hepatoma cell line Hepa-1.	Dioxins	79-85	aldehyde oxidase 1	Mus musculus	19-37
15664268-2	2005	We have identified aldehyde oxidase 1 (AOX1) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) inducible gene in the mouse hepatoma cell line Hepa-1.	Dioxins	79-85	aldehyde oxidase 1	Mus musculus	39-43
15664268-4	2005	Dioxin induction of AOX1 mRNA was also observed in mouse liver.	Dioxins	0-6	aldehyde oxidase 1	Mus musculus	20-24
15664268-5	2005	In addition, levels of AOX1 protein as well as those of aldehyde oxidase homologue 1 (AOH1), a recently identified homolog of AOX1, were elevated in mouse liver in response to dioxin.	Dioxins	176-182	aldehyde oxidase 1	Mus musculus	23-27
15664268-5	2005	In addition, levels of AOX1 protein as well as those of aldehyde oxidase homologue 1 (AOH1), a recently identified homolog of AOX1, were elevated in mouse liver in response to dioxin.	Dioxins	176-182	aldehyde oxidase 3	Mus musculus	56-84
15664268-5	2005	In addition, levels of AOX1 protein as well as those of aldehyde oxidase homologue 1 (AOH1), a recently identified homolog of AOX1, were elevated in mouse liver in response to dioxin.	Dioxins	176-182	aldehyde oxidase 3	Mus musculus	86-90
15664268-5	2005	In addition, levels of AOX1 protein as well as those of aldehyde oxidase homologue 1 (AOH1), a recently identified homolog of AOX1, were elevated in mouse liver in response to dioxin.	Dioxins	176-182	aldehyde oxidase 1	Mus musculus	126-130
15664268-6	2005	Employing an aldehyde oxidase specific substrate, AOX1/AOH1 activity was shown to be induced by dioxin in mouse liver.	Dioxins	96-102	aldehyde oxidase 1	Mus musculus	50-54
15664268-6	2005	Employing an aldehyde oxidase specific substrate, AOX1/AOH1 activity was shown to be induced by dioxin in mouse liver.	Dioxins	96-102	aldehyde oxidase 3	Mus musculus	55-59
15596250-9	2005	The CYP1B1*3 variant may have affected CYP1B1 expression in subjects highly and acutely exposed to dioxin at the time of the accident.	Dioxins	99-105	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	4-10
15596250-9	2005	The CYP1B1*3 variant may have affected CYP1B1 expression in subjects highly and acutely exposed to dioxin at the time of the accident.	Dioxins	99-105	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45
15758562-0	2005	Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling.	Dioxins	118-124	aryl hydrocarbon receptor repressor	Homo sapiens	70-105
15758562-5	2005	The results suggest that the AHRR Pro185Ala polymorphism may constitute a susceptibility locus for the development of MP in response to dioxins.	Dioxins	136-143	aryl hydrocarbon receptor repressor	Homo sapiens	29-33
15496506-11	2005	Because IGFBP-1 modulates blood glucose levels, the up-regulation of IGFBP-1 by dioxins might account for the disruptive effects of these pollutants on glucose metabolism.	Dioxins	80-87	insulin like growth factor binding protein 1	Homo sapiens	8-15
15659567-1	2005	Dioxins have been shown to bind and induce rodent CYP1A2, producing a dose-dependent hepatic sequestration in vivo.	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
15659567-2	2005	The induction of CYP1A2 activity has been used as a noninvasive biomarker for human exposure to dioxins; while there is a consistent relationship between exposure and hepatic CYP1A2 induction in rodents, this relationship has only been observed in some of the highest exposed human populations.	Dioxins	96-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
15570619-0	2005	Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues.	Dioxins	80-86	progesterone receptor membrane component 1	Rattus norvegicus	34-70
15570619-0	2005	Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues.	Dioxins	80-86	progestin and adipoQ receptor family member VII	Mus musculus	72-75
15570619-1	2005	We originally identified the membrane-bound progesterone receptor (mPR) using a screening for genes differentially expressed in liver of rats exposed to dioxin.	Dioxins	153-159	progesterone receptor membrane component 1	Rattus norvegicus	29-65
15570619-1	2005	We originally identified the membrane-bound progesterone receptor (mPR) using a screening for genes differentially expressed in liver of rats exposed to dioxin.	Dioxins	153-159	progestin and adipoQ receptor family member VII	Mus musculus	67-70
15570619-3	2005	In this study, we examined the expression pattern of the mPR in liver of rats exposed to dioxin and identified possible mechanisms of its regulation.	Dioxins	89-95	progestin and adipoQ receptor family member VII	Mus musculus	57-60
15570619-4	2005	We observed that mPR expression was induced by dioxin, but was also dependent on the hormonal responsiveness of the tissue.	Dioxins	47-53	progestin and adipoQ receptor family member VII	Mus musculus	17-20
15570619-5	2005	In particular, in male, but not female liver, dioxin induced the expression of the mPR.	Dioxins	46-52	progestin and adipoQ receptor family member VII	Mus musculus	83-86
15570619-7	2005	Moreover, in breast cancer cells MCF-7 dioxin induced mPR expression.	Dioxins	39-45	progestin and adipoQ receptor family member VII	Mus musculus	54-57
15570619-8	2005	Promoter studies using the luciferase assay indicated that a fragment of approximately 350 bp of the mPR promoter was able to induce luciferase activity in the presence of dioxin, suggesting that the presumptive XREs sites contained in this mPR promoter region are responsive to dioxin.	Dioxins	172-178	progestin and adipoQ receptor family member VII	Mus musculus	101-104
15570619-8	2005	Promoter studies using the luciferase assay indicated that a fragment of approximately 350 bp of the mPR promoter was able to induce luciferase activity in the presence of dioxin, suggesting that the presumptive XREs sites contained in this mPR promoter region are responsive to dioxin.	Dioxins	172-178	progestin and adipoQ receptor family member VII	Mus musculus	241-244
15570619-8	2005	Promoter studies using the luciferase assay indicated that a fragment of approximately 350 bp of the mPR promoter was able to induce luciferase activity in the presence of dioxin, suggesting that the presumptive XREs sites contained in this mPR promoter region are responsive to dioxin.	Dioxins	279-285	progestin and adipoQ receptor family member VII	Mus musculus	101-104
15570619-8	2005	Promoter studies using the luciferase assay indicated that a fragment of approximately 350 bp of the mPR promoter was able to induce luciferase activity in the presence of dioxin, suggesting that the presumptive XREs sites contained in this mPR promoter region are responsive to dioxin.	Dioxins	279-285	progestin and adipoQ receptor family member VII	Mus musculus	241-244
15537747-0	2005	Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity.	Dioxins	118-124	aryl-hydrocarbon receptor	Mus musculus	0-25
15537747-3	2005	Upon ligand binding, AhR translocates to the nucleus, dimerizes with the AhR nuclear translocator protein (Arnt), and regulates transcription by interaction with dioxin-response elements (DREs) in target genes, most notably specific cytochrome P450 (CYP) family members.	Dioxins	162-168	aryl-hydrocarbon receptor	Mus musculus	21-24
15537747-3	2005	Upon ligand binding, AhR translocates to the nucleus, dimerizes with the AhR nuclear translocator protein (Arnt), and regulates transcription by interaction with dioxin-response elements (DREs) in target genes, most notably specific cytochrome P450 (CYP) family members.	Dioxins	162-168	aryl hydrocarbon receptor nuclear translocator	Mus musculus	107-111
15537747-7	2005	Transcriptionally active AhR was detected in immature cerebellar granule cells in a transgenic dioxin-responsive lacZ mouse model after acute TCDD exposure.	Dioxins	95-101	aryl-hydrocarbon receptor	Mus musculus	25-28
15642610-3	2005	The dioxin-like PCB congener 3,4,3",4"-tetrachlorobiphenyl (PCB 77) has estrogenic and anti-estrogenic properties, and has been shown to affect brain chemistry and behavior of developing rats when administered during gestation.	Dioxins	4-10	pyruvate carboxylase	Rattus norvegicus	16-19
15642610-3	2005	The dioxin-like PCB congener 3,4,3",4"-tetrachlorobiphenyl (PCB 77) has estrogenic and anti-estrogenic properties, and has been shown to affect brain chemistry and behavior of developing rats when administered during gestation.	Dioxins	4-10	pyruvate carboxylase	Rattus norvegicus	60-63
15627472-7	2005	The mammalian AHR maintains normal liver function in the absence of exogenous ligands and, when activated by dioxin, cross-talks with morphogenetic and developmental signals.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	14-17
15627472-8	2005	Toxic end points, such as the induction of cleft palate by dioxin in mice embryos, might be at the crossroads of these signals and provide important clues as to the developmental role of the AHR.	Dioxins	59-65	aryl-hydrocarbon receptor	Mus musculus	191-194
15620708-0	2005	A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.	Dioxins	2-8	WAPL cohesin release factor	Homo sapiens	35-39
15471898-9	2005	Co-transfected with luciferase reporter vectors containing either the regulatory upstream sequence of the CYP2B1 gene or three dioxin-responsive core elements were activated by S33Y-beta-catenin.	Dioxins	127-133	catenin (cadherin associated protein), beta 1	Mus musculus	182-194
15496506-11	2005	Because IGFBP-1 modulates blood glucose levels, the up-regulation of IGFBP-1 by dioxins might account for the disruptive effects of these pollutants on glucose metabolism.	Dioxins	80-87	insulin like growth factor binding protein 1	Homo sapiens	69-76
15626646-1	2005	Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on a potency-adjusted dose-additive combination of constituents of the mixture.	Dioxins	11-17	TEF transcription factor, PAR bZIP family member	Homo sapiens	18-42
15626646-1	2005	Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on a potency-adjusted dose-additive combination of constituents of the mixture.	Dioxins	11-17	TEF transcription factor, PAR bZIP family member	Homo sapiens	44-47
15626646-1	2005	Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on a potency-adjusted dose-additive combination of constituents of the mixture.	Dioxins	121-127	TEF transcription factor, PAR bZIP family member	Homo sapiens	18-42
15626646-1	2005	Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on a potency-adjusted dose-additive combination of constituents of the mixture.	Dioxins	121-127	TEF transcription factor, PAR bZIP family member	Homo sapiens	44-47
15626646-6	2005	These data support the use of the TEF approach for dioxin cancer risk assessments.	Dioxins	51-57	TEF transcription factor, PAR bZIP family member	Homo sapiens	34-37
15667070-4	2005	Light produced by the extracts is a function of the concentrations and potencies of those compounds with an affinity for Ah-receptor (certain polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins/ furans).	Dioxins	207-214	aryl hydrocarbon receptor	Homo sapiens	121-132
15915147-2	2005	Induction of the CYP1A gene is mediated by an aryl hydrocarbon receptor (AHR) which binds to a specific nucleotide sequence called a dioxin-responsive element (DRE) located in the 5" enhancer region of the gene.	Dioxins	133-139	cytochrome P450 1A1	Oryzias latipes	17-22
15915147-2	2005	Induction of the CYP1A gene is mediated by an aryl hydrocarbon receptor (AHR) which binds to a specific nucleotide sequence called a dioxin-responsive element (DRE) located in the 5" enhancer region of the gene.	Dioxins	133-139	aryl hydrocarbon receptor 1b	Oryzias latipes	46-71
15915147-2	2005	Induction of the CYP1A gene is mediated by an aryl hydrocarbon receptor (AHR) which binds to a specific nucleotide sequence called a dioxin-responsive element (DRE) located in the 5" enhancer region of the gene.	Dioxins	133-139	aryl hydrocarbon receptor 1b	Oryzias latipes	73-76
15857025-4	2005	Dioxin- and estrogen-linked genes (AhR, ERalpha, ERbeta, CYP1A1 and ARNT) expressed were determined with the RT-PCR method.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	35-38
15857025-4	2005	Dioxin- and estrogen-linked genes (AhR, ERalpha, ERbeta, CYP1A1 and ARNT) expressed were determined with the RT-PCR method.	Dioxins	0-6	estrogen receptor 1	Homo sapiens	40-47
15857025-4	2005	Dioxin- and estrogen-linked genes (AhR, ERalpha, ERbeta, CYP1A1 and ARNT) expressed were determined with the RT-PCR method.	Dioxins	0-6	estrogen receptor 2	Homo sapiens	49-55
15857025-4	2005	Dioxin- and estrogen-linked genes (AhR, ERalpha, ERbeta, CYP1A1 and ARNT) expressed were determined with the RT-PCR method.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-63
15857025-4	2005	Dioxin- and estrogen-linked genes (AhR, ERalpha, ERbeta, CYP1A1 and ARNT) expressed were determined with the RT-PCR method.	Dioxins	0-6	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	68-72
16358414-3	2005	Towards this end, we first performed equilibrium binding and dissociation rate analyses using a single dioxin response element (DRE-1).	Dioxins	103-109	kelch like family member 24	Homo sapiens	128-133
15934323-1	2005	A novel exonuclease protection mediated PCR assay (EPM-PCR) to detect the interaction of protein and DNA at a dioxin-responsive enhancer (DRE) upstream of the CYP1A1 gene in rat hepatic cytosol was established.	Dioxins	110-116	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	159-165
15961252-2	2005	Nevertheless, it appears that the receptor (AhR) itself causes the expression of oestrogen-regulated target genes (studied by binding of dioxin).	Dioxins	137-143	aryl hydrocarbon receptor	Homo sapiens	44-47
15773294-1	2005	The reporter gene expression method CALUX cell bioassay has proven to be a very valuable screening technique for assessing toxic equivalents of dioxin and dioxin-like compounds, because it detects all AhR ligands in a variety of sample matrices.	Dioxins	144-150	aryl hydrocarbon receptor	Homo sapiens	201-204
19003047-2	2005	The stable dioxin-responsive cell line was established by introducing a plasmid incorporating the human CYP1A1 promoter into human hepatic HepG2 genomic DNA upstream of the luciferase gene.	Dioxins	11-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
15773294-1	2005	The reporter gene expression method CALUX cell bioassay has proven to be a very valuable screening technique for assessing toxic equivalents of dioxin and dioxin-like compounds, because it detects all AhR ligands in a variety of sample matrices.	Dioxins	155-161	aryl hydrocarbon receptor	Homo sapiens	201-204
18248194-0	2005	Isolation and characterization of a dioxin-inducible CYP1A1 promoter/enhancer region from zebrafish (Danio rerio).	Dioxins	36-42	cytochrome P450, family 1, subfamily A	Danio rerio	53-59
15781987-12	2004	The spatio-temporal expression of AhR during the peri-implantation phase of the mouse uterus may indicate functional roles of this orphan receptor in fetomaternal interactions as well as substantiate the risk of exposure to chemicals such as dioxins during the reproductive period.	Dioxins	242-249	aryl-hydrocarbon receptor	Mus musculus	34-37
15483185-3	2005	The "dioxin-like" PCB congeners, PCB 126, PCB 105, and 4"-OH-PCB 79, a metabolite of the planar PCB 77 congener, induced cell proliferation in a concentration-dependent manner.	Dioxins	5-11	pyruvate carboxylase	Rattus norvegicus	18-21
15483185-3	2005	The "dioxin-like" PCB congeners, PCB 126, PCB 105, and 4"-OH-PCB 79, a metabolite of the planar PCB 77 congener, induced cell proliferation in a concentration-dependent manner.	Dioxins	5-11	pyruvate carboxylase	Rattus norvegicus	33-36
15483185-3	2005	The "dioxin-like" PCB congeners, PCB 126, PCB 105, and 4"-OH-PCB 79, a metabolite of the planar PCB 77 congener, induced cell proliferation in a concentration-dependent manner.	Dioxins	5-11	pyruvate carboxylase	Rattus norvegicus	33-36
15483185-3	2005	The "dioxin-like" PCB congeners, PCB 126, PCB 105, and 4"-OH-PCB 79, a metabolite of the planar PCB 77 congener, induced cell proliferation in a concentration-dependent manner.	Dioxins	5-11	pyruvate carboxylase	Rattus norvegicus	33-36
15483185-3	2005	The "dioxin-like" PCB congeners, PCB 126, PCB 105, and 4"-OH-PCB 79, a metabolite of the planar PCB 77 congener, induced cell proliferation in a concentration-dependent manner.	Dioxins	5-11	pyruvate carboxylase	Rattus norvegicus	33-36
15483185-5	2005	The concentrations of dioxin-like PCBs leading to cell proliferation corresponded with the levels inducing the expression of cytochrome P450 1A1 mRNA, suggesting that the release from contact inhibition was associated with AhR activation.	Dioxins	22-28	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	125-144
15483185-5	2005	The concentrations of dioxin-like PCBs leading to cell proliferation corresponded with the levels inducing the expression of cytochrome P450 1A1 mRNA, suggesting that the release from contact inhibition was associated with AhR activation.	Dioxins	22-28	aryl hydrocarbon receptor	Rattus norvegicus	223-226
15483185-10	2005	These results suggest that dioxin-like PCBs can induce cell proliferation of contact-inhibited rat liver epithelial cells by increasing cyclin A protein levels, a process that then leads to upregulation of cyclin A/cdk2 activity and initiation of DNA replication.	Dioxins	27-33	cyclin dependent kinase 2	Rattus norvegicus	215-219
15485806-0	2004	Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia.	Dioxins	186-192	thyroid hormone receptor interactor 11	Homo sapiens	15-78
15485806-0	2004	Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia.	Dioxins	186-192	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	86-132
15485806-1	2004	The aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor (ARNT/HIF-1 beta) mediates an organism"s response to various environmental cues, including those to chemical carcinogens, such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD or dioxin), via its formation of a functional transcription factor with the ligand activated aryl hydrocarbon receptor (AHR).	Dioxins	237-243	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	4-50
15485806-1	2004	The aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor (ARNT/HIF-1 beta) mediates an organism"s response to various environmental cues, including those to chemical carcinogens, such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD or dioxin), via its formation of a functional transcription factor with the ligand activated aryl hydrocarbon receptor (AHR).	Dioxins	237-243	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	77-81
15485806-1	2004	The aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor (ARNT/HIF-1 beta) mediates an organism"s response to various environmental cues, including those to chemical carcinogens, such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD or dioxin), via its formation of a functional transcription factor with the ligand activated aryl hydrocarbon receptor (AHR).	Dioxins	237-243	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	82-92
15485806-1	2004	The aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor (ARNT/HIF-1 beta) mediates an organism"s response to various environmental cues, including those to chemical carcinogens, such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD or dioxin), via its formation of a functional transcription factor with the ligand activated aryl hydrocarbon receptor (AHR).	Dioxins	237-243	aryl hydrocarbon receptor	Homo sapiens	4-29
15485806-1	2004	The aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor (ARNT/HIF-1 beta) mediates an organism"s response to various environmental cues, including those to chemical carcinogens, such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD or dioxin), via its formation of a functional transcription factor with the ligand activated aryl hydrocarbon receptor (AHR).	Dioxins	237-243	aryl hydrocarbon receptor	Homo sapiens	370-373
15581363-1	2004	The arylhydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that regulates the transcription of genes encoding xenobiotic metabolizing enzymes and also mediates most of the toxic effects caused by dioxins and polycyclic aromatic hydrocarbons.	Dioxins	225-232	aryl hydrocarbon receptor	Homo sapiens	4-28
15581363-1	2004	The arylhydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that regulates the transcription of genes encoding xenobiotic metabolizing enzymes and also mediates most of the toxic effects caused by dioxins and polycyclic aromatic hydrocarbons.	Dioxins	225-232	aryl hydrocarbon receptor	Homo sapiens	30-33
15781987-1	2004	The arylhydrocarbon receptor (AhR) is a nuclear transcription factor mediating toxic effects of chemicals such as dioxins.	Dioxins	114-121	aryl-hydrocarbon receptor	Mus musculus	4-28
15781987-1	2004	The arylhydrocarbon receptor (AhR) is a nuclear transcription factor mediating toxic effects of chemicals such as dioxins.	Dioxins	114-121	aryl-hydrocarbon receptor	Mus musculus	30-33
15649379-1	2005	Dioxin and related chemicals cause a variety of toxic and biological effects via the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	85-110
15649379-1	2005	Dioxin and related chemicals cause a variety of toxic and biological effects via the aryl hydrocarbon receptor (AhR).	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	112-115
15371557-9	2004	Promoter analysis revealed the presence of four dioxin-response elements within 1000 base pairs upstream of the Socs2 transcriptional start site, and a reporter gene regulated by the Socs2 promoter was inducible by TCDD.	Dioxins	48-54	suppressor of cytokine signaling 2	Mus musculus	112-117
15371557-9	2004	Promoter analysis revealed the presence of four dioxin-response elements within 1000 base pairs upstream of the Socs2 transcriptional start site, and a reporter gene regulated by the Socs2 promoter was inducible by TCDD.	Dioxins	48-54	suppressor of cytokine signaling 2	Mus musculus	183-188
15474616-2	2004	We have examined the effects of acute perfusion of 3,3",4,4"-tetrachlorobiphenyl (PCB 77), a coplanar, dioxin-like congener, on long-term potentiation (LTP) in the Schaffer collateral-CA1 and the mossy fiber-CA3 pathways in mouse hippocampus.	Dioxins	103-109	pyruvate carboxylase	Homo sapiens	82-85
15474616-6	2004	These observations provide evidence in support of the hypothesis that dioxin-like and non-dioxin-like PCB congeners are equally potent in causing the cognitive decrements seen in children exposed prenatally to PCBs.	Dioxins	90-96	pyruvate carboxylase	Homo sapiens	102-105
15545609-0	2004	Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development.	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	24-27
15545609-0	2004	Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development.	Dioxins	51-57	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	32-36
15545609-1	2004	The aryl hydrocarbon receptor (AHR) is commonly known for its role in the adaptive metabolism of xenobiotics and in the toxic events that follow exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	186-192	aryl hydrocarbon receptor	Homo sapiens	4-29
15545609-1	2004	The aryl hydrocarbon receptor (AHR) is commonly known for its role in the adaptive metabolism of xenobiotics and in the toxic events that follow exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	186-192	aryl hydrocarbon receptor	Homo sapiens	31-34
15545609-5	2004	By manipulating gestational exposure, the patent DV in AHR or ARNT hypomorphs could be efficiently closed by dioxin exposure as early as embryonic day 12.5 and as late as embryonic day 18.5.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	55-58
15545609-5	2004	By manipulating gestational exposure, the patent DV in AHR or ARNT hypomorphs could be efficiently closed by dioxin exposure as early as embryonic day 12.5 and as late as embryonic day 18.5.	Dioxins	109-115	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	62-66
15598615-7	2004	In summary, DNA microarray successfully identified dioxin-responsive genes expressed after exposure to AhR ligands (TCDD, PeCDF, PCB126) but not after exposure to the non-AhR ligand PCB153.	Dioxins	51-57	aryl hydrocarbon receptor	Rattus norvegicus	103-106
15598615-7	2004	In summary, DNA microarray successfully identified dioxin-responsive genes expressed after exposure to AhR ligands (TCDD, PeCDF, PCB126) but not after exposure to the non-AhR ligand PCB153.	Dioxins	51-57	aryl hydrocarbon receptor	Rattus norvegicus	171-174
15598615-8	2004	Together, these findings may help to elucidate some of the fundamental features of dioxin toxicity and may further clarify the biologic role of the AhR signaling pathway.	Dioxins	83-89	aryl hydrocarbon receptor	Rattus norvegicus	148-151
15592584-4	2004	Studies of realistic lifelong AhR activation by dioxins on the hypothalamic-pituitary-ovarian axis and its impact on the transition to reproductive senescence in the aging female are a previously neglected area of research that warrants further consideration.	Dioxins	48-55	aryl hydrocarbon receptor	Homo sapiens	30-33
15369848-1	2004	Dioxin-like polychlorinated biphenyls (PCBs) exert their toxicities by activating the arylhydrocarbon receptor (AhR), a ligand-dependent transcription factor, in a similar manner to the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	197-203	aryl-hydrocarbon receptor	Mus musculus	86-110
15369848-1	2004	Dioxin-like polychlorinated biphenyls (PCBs) exert their toxicities by activating the arylhydrocarbon receptor (AhR), a ligand-dependent transcription factor, in a similar manner to the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Dioxins	197-203	aryl-hydrocarbon receptor	Mus musculus	112-115
15369848-7	2004	These results indicate that dioxin-like PCBs, especially PCB169, shows deviating REPs against immune reactions, and also suggest that PCB169-liganded AhR behaves differently from TCDD-liganded AhR in immune cells.	Dioxins	28-34	aryl-hydrocarbon receptor	Mus musculus	150-153
15369848-7	2004	These results indicate that dioxin-like PCBs, especially PCB169, shows deviating REPs against immune reactions, and also suggest that PCB169-liganded AhR behaves differently from TCDD-liganded AhR in immune cells.	Dioxins	28-34	aryl-hydrocarbon receptor	Mus musculus	193-196
15450424-2	2004	Interestingly, even though the DNA sequence identifies it as the sole member of the new CYP2S family, CYP2S1 exhibits many features typical to CYP1 family members, e.g. dioxin-inducibility mediated by the aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	169-175	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	102-108
15450424-2	2004	Interestingly, even though the DNA sequence identifies it as the sole member of the new CYP2S family, CYP2S1 exhibits many features typical to CYP1 family members, e.g. dioxin-inducibility mediated by the aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	169-175	aryl hydrocarbon receptor	Homo sapiens	205-230
15450424-2	2004	Interestingly, even though the DNA sequence identifies it as the sole member of the new CYP2S family, CYP2S1 exhibits many features typical to CYP1 family members, e.g. dioxin-inducibility mediated by the aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	169-175	aryl hydrocarbon receptor	Homo sapiens	232-235
15450424-2	2004	Interestingly, even though the DNA sequence identifies it as the sole member of the new CYP2S family, CYP2S1 exhibits many features typical to CYP1 family members, e.g. dioxin-inducibility mediated by the aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	169-175	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	245-291
15450424-2	2004	Interestingly, even though the DNA sequence identifies it as the sole member of the new CYP2S family, CYP2S1 exhibits many features typical to CYP1 family members, e.g. dioxin-inducibility mediated by the aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	169-175	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	293-297
15386136-0	2004	Dioxins and related compounds in human breast milk collected around open dumping sites in Asian developing countries: bovine milk as a potential source.	Dioxins	0-7	Weaning weight-maternal milk	Bos taurus	46-50
15386136-1	2004	In this study, concentrations of dioxins and related compounds (DRCs)--such as polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls--were found in human breast milk from women living near dumping sites of municipal waste and reference sites in India, Cambodia, Vietnam, and the Philippines during 1999 to 2000.	Dioxins	33-40	Weaning weight-maternal milk	Bos taurus	213-217
15142886-6	2004	Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling.	Dioxins	198-204	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28
15142886-6	2004	Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling.	Dioxins	198-204	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40
15352264-4	2004	Together with our previous work, our results suggest that formation of the Ah receptor-ligand-DRE (dioxin response element) complex is the principal point of divergence in the mechanism between an AhR agonist and an AhR antagonist.	Dioxins	99-105	aryl hydrocarbon receptor	Rattus norvegicus	75-86
15352264-4	2004	Together with our previous work, our results suggest that formation of the Ah receptor-ligand-DRE (dioxin response element) complex is the principal point of divergence in the mechanism between an AhR agonist and an AhR antagonist.	Dioxins	99-105	aryl hydrocarbon receptor	Rattus norvegicus	197-200
15352264-4	2004	Together with our previous work, our results suggest that formation of the Ah receptor-ligand-DRE (dioxin response element) complex is the principal point of divergence in the mechanism between an AhR agonist and an AhR antagonist.	Dioxins	99-105	aryl hydrocarbon receptor	Rattus norvegicus	216-219
15474075-0	2004	Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins.	Dioxins	147-154	aryl hydrocarbon receptor repressor	Homo sapiens	67-102
15313166-3	2004	The AhR/Arnt heterodimer then binds to the dioxin-response elements (DREs) in the cyp1a1 enhancer and stimulates transcription of cyp1a1.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	4-7
15313166-3	2004	The AhR/Arnt heterodimer then binds to the dioxin-response elements (DREs) in the cyp1a1 enhancer and stimulates transcription of cyp1a1.	Dioxins	43-49	aryl hydrocarbon receptor nuclear translocator	Mus musculus	8-12
15313166-3	2004	The AhR/Arnt heterodimer then binds to the dioxin-response elements (DREs) in the cyp1a1 enhancer and stimulates transcription of cyp1a1.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
15313166-3	2004	The AhR/Arnt heterodimer then binds to the dioxin-response elements (DREs) in the cyp1a1 enhancer and stimulates transcription of cyp1a1.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	130-136
15313166-7	2004	Overexpression of dominant negative form of p42 MAPK suppressed TCDD-dependent transcription of a reporter gene controlled by dioxin-response elements (DREs), and pretreatment with PD98059 also blocked this transcription.	Dioxins	126-132	mitogen-activated protein kinase 1	Mus musculus	44-52
15288808-2	2004	The AhR-Arnt heterodimer binds to the dioxin response element (DRE) to regulate target gene expression.	Dioxins	38-44	aryl hydrocarbon receptor	Oryctolagus cuniculus	4-7
15288808-2	2004	The AhR-Arnt heterodimer binds to the dioxin response element (DRE) to regulate target gene expression.	Dioxins	38-44	aryl hydrocarbon receptor nuclear translocator	Oryctolagus cuniculus	8-12
15474075-10	2004	CONCLUSION(S): The Pro185Ala polymorphism in AHRR may constitute a susceptibility locus for dioxin-related male infertility.	Dioxins	92-98	aryl hydrocarbon receptor repressor	Homo sapiens	45-49
15474075-11	2004	It appears that the negative feedback effect of AHRR on dioxin-related signaling is weaker for the proline allele than for the alanine allele, and that the hypomorphic function of the proline allele exerts a recessive adverse effect on male fertility.	Dioxins	56-62	aryl hydrocarbon receptor repressor	Homo sapiens	48-52
18969555-4	2004	These differences are more marked for the dioxin like PCB compounds (CALUX TEQ values are lower than WHO TEQ values) than for the dioxin compounds (CALUX TEQ values are higher than WHO TEQ values).	Dioxins	42-48	pyruvate carboxylase	Homo sapiens	54-57
18969556-1	2004	The reporter gene expression method CALUX has proven to be a very valuable screening technique for assessing toxic equivalents of dioxins and dioxin-like compounds, because it detects all AhR ligands in a variety of sample matrices.	Dioxins	130-137	aryl hydrocarbon receptor	Homo sapiens	188-191
18969556-1	2004	The reporter gene expression method CALUX has proven to be a very valuable screening technique for assessing toxic equivalents of dioxins and dioxin-like compounds, because it detects all AhR ligands in a variety of sample matrices.	Dioxins	130-136	aryl hydrocarbon receptor	Homo sapiens	188-191
18969556-8	2004	Using only an acidic silica column, the classical dioxin-like compounds investigated here (PCB, PCT, PBB, PCN, HCB) as well as the dioxins are collected and analyzed altogether in one fraction.	Dioxins	50-56	pyruvate carboxylase	Homo sapiens	91-94
18969556-10	2004	An acidic silica column combined with an activated carbon column allows the separation of PCDD/F and dioxin-like PCB in two different fractions, PBB 169 is completely eluted in the dioxin fraction and PBB 77 is distributed between the PCB and dioxin fraction.	Dioxins	101-107	pyruvate carboxylase	Homo sapiens	113-116
18969559-4	2004	The chemical-activated luciferase bioassay (CALUX) bioassay uses a recombinant cell line, which responds to dioxins and dioxin-like molecules with Ah receptor (AhR)-dependent induction of firefly luciferase in a dose related response.	Dioxins	108-115	aryl hydrocarbon receptor	Homo sapiens	147-158
18969559-4	2004	The chemical-activated luciferase bioassay (CALUX) bioassay uses a recombinant cell line, which responds to dioxins and dioxin-like molecules with Ah receptor (AhR)-dependent induction of firefly luciferase in a dose related response.	Dioxins	108-115	aryl hydrocarbon receptor	Homo sapiens	160-163
18969559-4	2004	The chemical-activated luciferase bioassay (CALUX) bioassay uses a recombinant cell line, which responds to dioxins and dioxin-like molecules with Ah receptor (AhR)-dependent induction of firefly luciferase in a dose related response.	Dioxins	108-114	aryl hydrocarbon receptor	Homo sapiens	147-158
18969559-4	2004	The chemical-activated luciferase bioassay (CALUX) bioassay uses a recombinant cell line, which responds to dioxins and dioxin-like molecules with Ah receptor (AhR)-dependent induction of firefly luciferase in a dose related response.	Dioxins	108-114	aryl hydrocarbon receptor	Homo sapiens	160-163
15212819-1	2004	Our previous results describing the CH12.LX (AhR-expressing) and BCL-1 (AhR-deficient) B cell lines have supported an AhR/dioxin-responsive element (DRE)-mediated mechanism for TCDD-induced inhibition of micro heavy chain expression and thus of IgM secretion.	Dioxins	122-128	aryl-hydrocarbon receptor	Mus musculus	45-48
15212819-1	2004	Our previous results describing the CH12.LX (AhR-expressing) and BCL-1 (AhR-deficient) B cell lines have supported an AhR/dioxin-responsive element (DRE)-mediated mechanism for TCDD-induced inhibition of micro heavy chain expression and thus of IgM secretion.	Dioxins	122-128	cyclin D1	Mus musculus	65-70
15212819-1	2004	Our previous results describing the CH12.LX (AhR-expressing) and BCL-1 (AhR-deficient) B cell lines have supported an AhR/dioxin-responsive element (DRE)-mediated mechanism for TCDD-induced inhibition of micro heavy chain expression and thus of IgM secretion.	Dioxins	122-128	aryl-hydrocarbon receptor	Mus musculus	72-75
15212819-1	2004	Our previous results describing the CH12.LX (AhR-expressing) and BCL-1 (AhR-deficient) B cell lines have supported an AhR/dioxin-responsive element (DRE)-mediated mechanism for TCDD-induced inhibition of micro heavy chain expression and thus of IgM secretion.	Dioxins	122-128	aryl-hydrocarbon receptor	Mus musculus	72-75
15330552-5	2004	Relative to some dioxin-like PCB congeners (mono-ortho PCB 105, 118, and 156; non-ortho PCB 77, 126, and 169), the intakes calculated varied from less than 0.001 to 0.74 pg of toxic equivalency values (TEQ) per kg of body weight per day.	Dioxins	17-23	pyruvate carboxylase	Homo sapiens	29-32
15145931-1	2004	The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	176-182	aryl-hydrocarbon receptor	Mus musculus	4-29
15145931-1	2004	The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	176-182	aryl-hydrocarbon receptor	Mus musculus	46-49
15145931-3	2004	Using this strategy, we demonstrate that embryos from the Ahr(-/-) dams are 5-fold more sensitive to dioxin-induced cleft palate and hydronephrosis as compared with embryos from an Ahr(+/+) dam.	Dioxins	101-107	aryl-hydrocarbon receptor	Mus musculus	58-61
15145931-4	2004	Moreover, this increased teratogenic sensitivity extends beyond dioxin, because embryos from Ahr(-/-) dams exhibited a 9-fold increase in their sensitivity to the fetotoxic effects of the glucocorticoid, dexamethasone.	Dioxins	64-70	aryl-hydrocarbon receptor	Mus musculus	93-96
15145931-5	2004	In searching for an explanation for this increased sensitivity, we found that more dioxin and dexamethasone reached the embryos from Ahr(-/-) dams as compared with embryos from Ahr(+/+) dams.	Dioxins	83-89	aryl-hydrocarbon receptor	Mus musculus	133-136
15256435-4	2004	Although several lines of evidence indicate the involvement of the AhR in toxic effects mediated by polyhalogenated biphenyls and dioxins, its involvement in tumor promotion has not been unequivocally proven.	Dioxins	130-137	aryl-hydrocarbon receptor	Mus musculus	67-70
14599506-10	2004	These results suggest that the sperm functions may be more susceptible or adapt less readily than the thyroid functions to endocrine disruption caused by dioxin-like PCB congeners.	Dioxins	154-160	pyruvate carboxylase	Rattus norvegicus	166-169
15136141-1	2004	The mammalian aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of dioxins and related compounds.	Dioxins	124-131	aryl hydrocarbon receptor	Homo sapiens	14-39
15136141-1	2004	The mammalian aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of dioxins and related compounds.	Dioxins	124-131	aryl hydrocarbon receptor	Homo sapiens	41-44
15114261-10	2004	CONCLUSIONS: The presence of AHR in sperm provides a mechanism by which environmental dioxins, polycyclic aromatic hydrocarbons and polyhalogenated biphenyls could directly influence sperm function.	Dioxins	86-93	aryl hydrocarbon receptor	Homo sapiens	29-32
14764592-0	2004	Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele.	Dioxins	26-32	aryl hydrocarbon receptor nuclear translocator	Mus musculus	76-80
14764592-5	2004	In this regard, the AHR is also known to mediate two additional biological processes: the toxicological response to compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) and the developmental closure of a fetal vascular structure known as the ductus venosus.	Dioxins	163-169	aryl-hydrocarbon receptor	Mus musculus	20-23
14764592-8	2004	Parallel dioxin toxicity studies demonstrated that the ARNT hypomorphs exhibited resistance to the end points of dioxin exposure.	Dioxins	9-15	aryl hydrocarbon receptor nuclear translocator	Mus musculus	55-59
14764592-8	2004	Parallel dioxin toxicity studies demonstrated that the ARNT hypomorphs exhibited resistance to the end points of dioxin exposure.	Dioxins	113-119	aryl hydrocarbon receptor nuclear translocator	Mus musculus	55-59
14764592-10	2004	Taken in sum, these experiments demonstrate that ARNT is an essential component of AHR developmental signaling and shed light on the mechanism of dioxin toxicity.	Dioxins	146-152	aryl hydrocarbon receptor nuclear translocator	Mus musculus	49-53
15087408-1	2004	The polycyclic aromatic hydrocarbon 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) is related to the industrial byproduct dioxin and is a weak agonist and partial antagonist at the aryl hydrocarbon receptor (AhR).	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	178-203
15087408-1	2004	The polycyclic aromatic hydrocarbon 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) is related to the industrial byproduct dioxin and is a weak agonist and partial antagonist at the aryl hydrocarbon receptor (AhR).	Dioxins	119-125	aryl hydrocarbon receptor	Homo sapiens	205-208
14726445-1	2004	The arylhydrocarbon receptor (AhR) is known to mediate toxic responses to dioxin (2,3,7,8-tetrachlorodibenzo-p- dioxin) and related compounds and has been extensively characterized from a toxicological viewpoint.	Dioxins	74-80	LOC522736	Bos taurus	4-28
14726445-1	2004	The arylhydrocarbon receptor (AhR) is known to mediate toxic responses to dioxin (2,3,7,8-tetrachlorodibenzo-p- dioxin) and related compounds and has been extensively characterized from a toxicological viewpoint.	Dioxins	74-80	LOC522736	Bos taurus	30-33
15099767-2	2004	After the binding of HAHs, the AhR subsequently transforms its form in order to interact with a specific DNA sequence, the dioxin responsive element (DRE).	Dioxins	123-129	aryl hydrocarbon receptor	Homo sapiens	31-34
17191862-0	2004	Guanine 6-O-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding.	Dioxins	43-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
17191862-0	2004	Guanine 6-O-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding.	Dioxins	43-49	aryl hydrocarbon receptor	Homo sapiens	124-127
17191862-0	2004	Guanine 6-O-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding.	Dioxins	43-49	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	128-132
17191862-1	2004	The core-recognition motif for TCDD-liganded AhR/ARNT complex of the dioxin-responsive element (DRE) contains four guanine residues, three on the antisense (5"-T(T)/(A)GCGTG-3") and one on the sense (5"-CACGC(A)/(T)A-3") strand.	Dioxins	69-75	aryl hydrocarbon receptor	Homo sapiens	45-48
17191862-1	2004	The core-recognition motif for TCDD-liganded AhR/ARNT complex of the dioxin-responsive element (DRE) contains four guanine residues, three on the antisense (5"-T(T)/(A)GCGTG-3") and one on the sense (5"-CACGC(A)/(T)A-3") strand.	Dioxins	69-75	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	49-53
14762110-7	2004	AhR activation by dioxin (TCDD) downregulated Ltbp-1, again suggesting an AhR-regulated mechanism.	Dioxins	18-24	aryl-hydrocarbon receptor	Mus musculus	0-3
14762110-7	2004	AhR activation by dioxin (TCDD) downregulated Ltbp-1, again suggesting an AhR-regulated mechanism.	Dioxins	18-24	latent transforming growth factor beta binding protein 1	Mus musculus	46-52
14762110-7	2004	AhR activation by dioxin (TCDD) downregulated Ltbp-1, again suggesting an AhR-regulated mechanism.	Dioxins	18-24	aryl-hydrocarbon receptor	Mus musculus	74-77
14625279-3	2004	We have shown previously that exposure of mouse hepatoma Hepa-1 cells to chromate inhibits the induction of the Cyp1a1 and Nqo1 genes by dioxin.	Dioxins	137-143	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	112-118
14625279-3	2004	We have shown previously that exposure of mouse hepatoma Hepa-1 cells to chromate inhibits the induction of the Cyp1a1 and Nqo1 genes by dioxin.	Dioxins	137-143	NAD(P)H dehydrogenase, quinone 1	Mus musculus	123-127
15071172-1	2004	The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	178-184	aryl hydrocarbon receptor	Homo sapiens	4-33
15071172-1	2004	The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	178-184	aryl hydrocarbon receptor	Homo sapiens	35-38
15084753-13	2004	Thus, the intraspecies genetic differences in C-terminal transactivation domain of AHR appear to modify the sensitivity to only certain dioxin-induced male reproductive effects.	Dioxins	136-142	aryl hydrocarbon receptor	Rattus norvegicus	83-86
15111621-0	2004	Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a.	Dioxins	0-6	tumor protein p53	Homo sapiens	78-81
15111621-0	2004	Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a.	Dioxins	0-6	cyclin dependent kinase inhibitor 2A	Homo sapiens	86-94
15111621-1	2004	Dioxin, a potent tumor promoter, activates the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor belonging to the basic helix-loop-helix-PAS family, to enhance tumorigenesis via unknown mechanisms.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	47-72
15111621-1	2004	Dioxin, a potent tumor promoter, activates the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor belonging to the basic helix-loop-helix-PAS family, to enhance tumorigenesis via unknown mechanisms.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	74-77
15111621-3	2004	We have previously shown that in primary human keratinocytes, dioxin attenuates senescence while retaining the proliferative capacity and represses expression of the tumor suppressors, p16(INK4a) and p53.	Dioxins	62-68	cyclin dependent kinase inhibitor 2A	Homo sapiens	185-188
15111621-3	2004	We have previously shown that in primary human keratinocytes, dioxin attenuates senescence while retaining the proliferative capacity and represses expression of the tumor suppressors, p16(INK4a) and p53.	Dioxins	62-68	cyclin dependent kinase inhibitor 2A	Homo sapiens	189-194
15111621-3	2004	We have previously shown that in primary human keratinocytes, dioxin attenuates senescence while retaining the proliferative capacity and represses expression of the tumor suppressors, p16(INK4a) and p53.	Dioxins	62-68	tumor protein p53	Homo sapiens	200-203
15111621-4	2004	Here, we show that repression of p16(INK4a) and p53 transcriptional activity by dioxin absolutely requires the AHR and is accompanied by promoter methylation.	Dioxins	80-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	33-36
15111621-4	2004	Here, we show that repression of p16(INK4a) and p53 transcriptional activity by dioxin absolutely requires the AHR and is accompanied by promoter methylation.	Dioxins	80-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	37-42
15111621-4	2004	Here, we show that repression of p16(INK4a) and p53 transcriptional activity by dioxin absolutely requires the AHR and is accompanied by promoter methylation.	Dioxins	80-86	tumor protein p53	Homo sapiens	48-51
15111621-4	2004	Here, we show that repression of p16(INK4a) and p53 transcriptional activity by dioxin absolutely requires the AHR and is accompanied by promoter methylation.	Dioxins	80-86	aryl hydrocarbon receptor	Homo sapiens	111-114
15077192-9	2004	As shown for TCDD (dioxin), this effect appears to be mediated through the AhR-dependent expression of p27(KIP1).	Dioxins	19-25	aryl hydrocarbon receptor	Homo sapiens	75-78
15077192-9	2004	As shown for TCDD (dioxin), this effect appears to be mediated through the AhR-dependent expression of p27(KIP1).	Dioxins	19-25	zinc ribbon domain containing 2	Homo sapiens	103-106
15077192-9	2004	As shown for TCDD (dioxin), this effect appears to be mediated through the AhR-dependent expression of p27(KIP1).	Dioxins	19-25	cyclin dependent kinase inhibitor 1B	Homo sapiens	107-111
14978034-1	2004	We delineate a mechanism by which dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD)-mediated formation of the aryl hydrocarbon receptor (AhR) DNA binding complex is disrupted by a single mutation at the conserved AhR tyrosine 9.	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	113-138
14978034-1	2004	We delineate a mechanism by which dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD)-mediated formation of the aryl hydrocarbon receptor (AhR) DNA binding complex is disrupted by a single mutation at the conserved AhR tyrosine 9.	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	140-143
14978034-1	2004	We delineate a mechanism by which dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD)-mediated formation of the aryl hydrocarbon receptor (AhR) DNA binding complex is disrupted by a single mutation at the conserved AhR tyrosine 9.	Dioxins	34-40	aryl hydrocarbon receptor	Homo sapiens	216-219
14978034-2	2004	Replacement of tyrosine 9 with the structurally conservative phenylalanine (AhRY9F) abolished binding to dioxin response element (DRE) D, E, and A and abrogated DRE-driven gene induction mediated by the AhR with no effect on TCDD binding, TCDD-induced nuclear localization, or ARNT heterodimerization.	Dioxins	105-111	aryl hydrocarbon receptor	Homo sapiens	76-79
15110081-0	2004	The dioxin-like pollutant PCB 126 (3,3",4,4",5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats.	Dioxins	4-10	pyruvate carboxylase	Rattus norvegicus	26-29
15110081-3	2004	In the present pilot study, 40 female rats were subjected to either exposure to the dioxin-like 3,3",4,4",5-pentachlorobiphenyl (PCB 126) or vehicle, as well as ovariectomy (OVX) or sham operation in a 2 x 2 factorial design over 12 weeks to explore potential interactions between estrogen status and PCB 126 exposure on cardiovascular risk factors.	Dioxins	84-90	pyruvate carboxylase	Rattus norvegicus	129-132
15118327-0	2004	Suppression of dioxin mediated aryl hydrocarbon receptor transformation by ethanolic extracts of propolis.	Dioxins	15-21	aryl hydrocarbon receptor	Homo sapiens	31-56
14684744-0	2004	Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A.	Dioxins	0-6	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	17-26
14684744-0	2004	Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A.	Dioxins	0-6	cathelicidin antimicrobial peptide	Mus musculus	55-59
14684744-1	2004	The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD = dioxin) has been shown to increase the expression of C/EBPbeta.	Dioxins	57-63	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	125-134
14659948-8	2004	The total dioxin/PCB level in milk, venous and cord serum can be well predicted by that in placenta through regression functions.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	17-20
15075793-7	2004	The excess risk for exposed women with a Val CYP1B1 homo/heterozygous genotype could result from a higher exposure to activated metabolites of pesticides or dioxin-like substances.	Dioxins	157-163	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	45-51
14729976-4	2004	We detected three xenobiotic response elements (XREs) and one E-box consensus sequence in the rabbit Aldh1a1 upstream region; these elements are prevalent in other highly expressed corneal genes and can mediate stimulation by dioxin and repression by CoCl(2), which simulates hypoxia.	Dioxins	226-232	aldehyde dehydrogenase 1A1	Oryctolagus cuniculus	101-108
14729976-5	2004	The rabbit Aldh1a1 promoter was stimulated fourfold by dioxin in human hepatoma cells and repressed threefold by CoCl(2) treatment in rabbit corneal stromal and epithelial cells.	Dioxins	55-61	aldehyde dehydrogenase 1A1	Oryctolagus cuniculus	11-18
15077014-3	2004	Here, we report that the killifish AHR1 locus is highly polymorphic and that the frequencies of the major allele types differ between dioxin-sensitive and dioxin-resistant populations.	Dioxins	134-140	aryl hydrocarbon receptor-like	Fundulus heteroclitus	35-39
15077014-3	2004	Here, we report that the killifish AHR1 locus is highly polymorphic and that the frequencies of the major allele types differ between dioxin-sensitive and dioxin-resistant populations.	Dioxins	155-161	aryl hydrocarbon receptor-like	Fundulus heteroclitus	35-39
15077014-6	2004	AHR1*1 alleles were under-represented in a population of dioxin- and polychlorinated biphenyl (PCB)-resistant fish from a PCB-contaminated Superfund site (New Bedford Harbor, Massachusetts, USA) compared to dioxin-sensitive fish from a less contaminated reference site (Scorton Creek, Massachusetts, USA).	Dioxins	57-63	aryl hydrocarbon receptor-like	Fundulus heteroclitus	0-4
15077014-10	2004	We discuss the possibility of other functional differences in AHR1 variants or their interaction with other killifish loci (AHR2, AHRR) that may contribute to differences in dioxin sensitivity.	Dioxins	174-180	aryl hydrocarbon receptor-like	Fundulus heteroclitus	62-66
15077014-10	2004	We discuss the possibility of other functional differences in AHR1 variants or their interaction with other killifish loci (AHR2, AHRR) that may contribute to differences in dioxin sensitivity.	Dioxins	174-180	aryl hydrocarbon receptor repressor	Fundulus heteroclitus	130-134
14736496-1	2004	The toxic equivalency factor (TEF) method has been used to characterize the toxicity of human mixtures of dioxin-like compounds and is being considered for use with other classes of potentially toxic agents.	Dioxins	106-112	TEF transcription factor, PAR bZIP family member	Homo sapiens	4-28
14736496-1	2004	The toxic equivalency factor (TEF) method has been used to characterize the toxicity of human mixtures of dioxin-like compounds and is being considered for use with other classes of potentially toxic agents.	Dioxins	106-112	TEF transcription factor, PAR bZIP family member	Homo sapiens	30-33
15630228-1	2004	Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	79-104
15630228-1	2004	Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	106-109
15034205-0	2004	Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice.	Dioxins	65-71	aryl-hydrocarbon receptor	Mus musculus	112-115
15531779-1	2004	Epidemiological data and in vivo animal experiments have indicated that exposure to the Ah-receptor (AhR) ligand dioxin and other dioxin-like compounds can lead to cardiovascular toxicity and atherosclerosis.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	88-99
15531779-1	2004	Epidemiological data and in vivo animal experiments have indicated that exposure to the Ah-receptor (AhR) ligand dioxin and other dioxin-like compounds can lead to cardiovascular toxicity and atherosclerosis.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	101-104
15531779-1	2004	Epidemiological data and in vivo animal experiments have indicated that exposure to the Ah-receptor (AhR) ligand dioxin and other dioxin-like compounds can lead to cardiovascular toxicity and atherosclerosis.	Dioxins	130-136	aryl hydrocarbon receptor	Homo sapiens	88-99
15531779-1	2004	Epidemiological data and in vivo animal experiments have indicated that exposure to the Ah-receptor (AhR) ligand dioxin and other dioxin-like compounds can lead to cardiovascular toxicity and atherosclerosis.	Dioxins	130-136	aryl hydrocarbon receptor	Homo sapiens	101-104
14559260-0	2004	Concentrations of dioxin-like PCB congeners in unweathered Aroclors by HRGC/HRMS using EPA Method 1668A.	Dioxins	18-24	pyruvate carboxylase	Homo sapiens	30-33
14559260-2	2004	These Aroclor composition data should allow improved characterization and risk assessment of PCB contamination at hazardous waste sites, particularly for dioxin-like PCB congeners.	Dioxins	154-160	pyruvate carboxylase	Homo sapiens	166-169
15330441-4	2004	The decomposition and removal efficiency (DRE) of dioxins increased slightly with 20% CaO in an oxidative atmosphere, while it decreased obviously in an inert atmosphere.	Dioxins	50-57	mummy	Drosophila melanogaster	86-89
14744201-3	2004	In 9-year-old children of the Rotterdam PCB--dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982).	Dioxins	45-51	pyruvate carboxylase	Homo sapiens	40-43
14646185-1	2003	The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to environmental contaminants such as dioxins, which have many adverse health effects.	Dioxins	149-156	aryl hydrocarbon receptor	Homo sapiens	4-29
14646185-1	2003	The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to environmental contaminants such as dioxins, which have many adverse health effects.	Dioxins	149-156	aryl hydrocarbon receptor	Homo sapiens	31-34
14646185-2	2003	We performed a preliminary screening of the inhibitory effects of vegetable constituents on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of AhR using the AhR-based bioassay for dioxins, the Ah-Immunoassay.	Dioxins	194-201	aryl hydrocarbon receptor	Homo sapiens	157-160
15500064-0	2003	Flavonoids and resveratrol as regulators of Ah-receptor activity: protection from dioxin toxicity.	Dioxins	82-88	aryl hydrocarbon receptor	Homo sapiens	44-55
15500064-2	2003	The toxic effects of dioxin are realized via its interaction with the Ah-receptor.	Dioxins	21-27	aryl hydrocarbon receptor	Homo sapiens	70-81
14530333-0	2003	T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution.	Dioxins	138-144	aryl-hydrocarbon receptor	Mus musculus	30-54
14530333-0	2003	T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution.	Dioxins	138-144	aryl hydrocarbon receptor nuclear translocator	Mus musculus	77-81
14529743-2	2003	Since AhR binding of a prototypical ligand such as dioxin is the first step in a cascade pathway producing major changes in gene expression, we reasoned that PbTx-6 might produce similar genomic-wide changes in expression.	Dioxins	51-57	aryl-hydrocarbon receptor	Mus musculus	6-9
14984010-7	2003	Real-time PCR and Western blot analysis clearly revealed that dioxin significantly downregulated NMDAR1 mRNA and protein expression during the first postnatal month.	Dioxins	62-68	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	97-103
14550747-2	2003	Many of the effects of dioxin are mediated by the aryl hydrocarbon receptor (AHR), a ligand-activated bHLH (basic helix-loop-helix)/PAS transcription factor.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	50-75
14550747-2	2003	Many of the effects of dioxin are mediated by the aryl hydrocarbon receptor (AHR), a ligand-activated bHLH (basic helix-loop-helix)/PAS transcription factor.	Dioxins	23-29	aryl hydrocarbon receptor	Homo sapiens	77-80
14550747-6	2003	Finally, dioxin decreases SA (senescence associated) beta-galactosidase staining, an indicator of senescence, in the differentiating keratinocytes.	Dioxins	9-15	galactosidase beta 1	Homo sapiens	53-71
14578154-0	2003	Correspondence re: K. Toide et al., Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.	Dioxins	239-246	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-64
14514769-5	2003	Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3",4,4",5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC.	Dioxins	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
14514769-6	2003	Furthermore, these two dioxins markedly augmented IL-8 production stimulated with fimbriae from Porphyromonas gingivalis, which is well-known as a pathogenic factor in periodontal diseases.	Dioxins	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
14744201-3	2004	In 9-year-old children of the Rotterdam PCB--dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982).	Dioxins	45-51	pyruvate carboxylase	Homo sapiens	76-79
12951469-1	2003	The aryl hydrocarbon receptor (AhR) mediates a spectrum of toxicological and biological effects of dioxins.	Dioxins	99-106	aryl-hydrocarbon receptor	Mus musculus	4-29
12951469-1	2003	The aryl hydrocarbon receptor (AhR) mediates a spectrum of toxicological and biological effects of dioxins.	Dioxins	99-106	aryl-hydrocarbon receptor	Mus musculus	31-34
12842597-3	2003	Initial screening of Presque Isle Bay sediment samples by gene expression microarray in mouse hepatocytes revealed prototypical dioxin-response genes such as cytochrome P450 1A1 and 1B1 (CYP1A1 and CYP1B1).	Dioxins	128-134	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	169-185
12842597-3	2003	Initial screening of Presque Isle Bay sediment samples by gene expression microarray in mouse hepatocytes revealed prototypical dioxin-response genes such as cytochrome P450 1A1 and 1B1 (CYP1A1 and CYP1B1).	Dioxins	128-134	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	187-193
12842597-3	2003	Initial screening of Presque Isle Bay sediment samples by gene expression microarray in mouse hepatocytes revealed prototypical dioxin-response genes such as cytochrome P450 1A1 and 1B1 (CYP1A1 and CYP1B1).	Dioxins	128-134	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	198-204
12906918-3	2003	The major strategy adopted in analyzing its major signaling pathways is to view the toxic actions of dioxin as the result of the Ah receptor-mediated expression of a major cellular emergency stress response signal.	Dioxins	101-107	aryl hydrocarbon receptor	Homo sapiens	129-140
12906918-8	2003	In the case of hepatocytes for instance, transforming growth factor-alpha plays a pivotal role in the dioxin-induced activation of the epidermal growth factor receptor and the extracellular signal-related kinase pathway, which acts as a signal to suppress apoptosis induced by cellular stress.	Dioxins	102-108	tumor necrosis factor	Homo sapiens	41-73
12906918-8	2003	In the case of hepatocytes for instance, transforming growth factor-alpha plays a pivotal role in the dioxin-induced activation of the epidermal growth factor receptor and the extracellular signal-related kinase pathway, which acts as a signal to suppress apoptosis induced by cellular stress.	Dioxins	102-108	epidermal growth factor receptor	Homo sapiens	135-167
12859983-0	2003	3"-methoxy-4"-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.	Dioxins	112-118	aryl hydrocarbon receptor	Homo sapiens	39-64
12859983-0	2003	3"-methoxy-4"-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.	Dioxins	112-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-92
12859983-2	2003	Stably transfected luciferase with dioxin responsive elements (DRE) in its promoter region has been commonly used as a reporter gene to study the mechanism of AhR signaling and compare potencies of TCDD and related compounds.	Dioxins	35-41	aryl hydrocarbon receptor	Homo sapiens	159-162
12730383-0	2003	Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.	Dioxins	21-27	aryl-hydrocarbon receptor	Mus musculus	34-58
12902195-8	2003	MCF-10A cells were less responsive toward dioxin-like compounds and the apparent EC(50) values for CYP1A1 and CYP1B1 induction in this study were 10-100 fold higher than in MCF-7 cells.	Dioxins	42-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
12902195-8	2003	MCF-10A cells were less responsive toward dioxin-like compounds and the apparent EC(50) values for CYP1A1 and CYP1B1 induction in this study were 10-100 fold higher than in MCF-7 cells.	Dioxins	42-48	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	110-116
12729704-0	2003	Effects of dietary habits and CYP1A1 polymorphisms on blood dioxin concentrations in Japanese men.	Dioxins	60-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
12916746-4	2003	The estimated dioxin exposure concentrations were 0.5 to 7.2 pg TEQ/m3 in the daily operation and 0.2 to 92,000 pg TEQ/m3 in the periodic maintenance.	Dioxins	14-20	Tequila	Drosophila melanogaster	64-67
12916746-6	2003	The mean of blood dioxin concentration was 346 pg TEQ/g lipid in the highest exposed worker group of the Toyono-gun incineration plant and those were 11 to 40 pg TEQ/ g lipid in the other incineration plants.	Dioxins	18-24	Tequila	Drosophila melanogaster	50-53
12972062-1	2003	Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism.	Dioxins	26-33	aryl-hydrocarbon receptor	Mus musculus	112-137
12972062-1	2003	Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism.	Dioxins	26-33	aryl hydrocarbon receptor	Homo sapiens	139-142
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor	Homo sapiens	31-56
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor	Homo sapiens	58-61
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	67-91
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	93-97
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor	Homo sapiens	67-70
12761348-2	2003	Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element.	Dioxins	282-288	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	188-192
12774124-5	2003	A heterodimer of the dioxin receptor (AhR) and Arnt, which are basic helix-loop-helix/PAS-family transcription factors, mediates most of the toxic effects of dioxins.	Dioxins	158-165	aryl-hydrocarbon receptor	Mus musculus	38-41
12774124-5	2003	A heterodimer of the dioxin receptor (AhR) and Arnt, which are basic helix-loop-helix/PAS-family transcription factors, mediates most of the toxic effects of dioxins.	Dioxins	158-165	aryl hydrocarbon receptor nuclear translocator	Mus musculus	47-51
12774124-10	2003	Our findings suggest a novel mechanism by which ER-mediated oestrogen signalling is modulated by a co-regulatory-like function of activated AhR/Arnt, giving rise to adverse oestrogen-related actions of dioxin-type environmental contaminants.	Dioxins	202-208	aryl-hydrocarbon receptor	Mus musculus	140-143
12774124-10	2003	Our findings suggest a novel mechanism by which ER-mediated oestrogen signalling is modulated by a co-regulatory-like function of activated AhR/Arnt, giving rise to adverse oestrogen-related actions of dioxin-type environmental contaminants.	Dioxins	202-208	aryl hydrocarbon receptor nuclear translocator	Mus musculus	144-148
12730383-0	2003	Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.	Dioxins	21-27	aryl-hydrocarbon receptor	Mus musculus	60-63
12730383-3	2003	The diverse responses of mammals to dioxin are strongly influenced by functional polymorphisms of the arylhydrocarbon receptor (AHR).	Dioxins	36-42	aryl-hydrocarbon receptor	Mus musculus	102-126
12730383-3	2003	The diverse responses of mammals to dioxin are strongly influenced by functional polymorphisms of the arylhydrocarbon receptor (AHR).	Dioxins	36-42	aryl-hydrocarbon receptor	Mus musculus	128-131
12646272-0	2003	Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements.	Dioxins	106-112	aryl-hydrocarbon receptor	Mus musculus	33-58
12646272-1	2003	Tyrosine phosphorylation of the aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix/PER-ARNT-SIM transcription factor family, has been shown to regulate its dioxin response elements (DRE) binding ability, although no specific residues have been directly demonstrated to be phosphorylated.	Dioxins	177-183	aryl-hydrocarbon receptor	Mus musculus	32-57
12646272-1	2003	Tyrosine phosphorylation of the aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix/PER-ARNT-SIM transcription factor family, has been shown to regulate its dioxin response elements (DRE) binding ability, although no specific residues have been directly demonstrated to be phosphorylated.	Dioxins	177-183	aryl-hydrocarbon receptor	Mus musculus	59-62
12673023-1	2003	Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity.	Dioxins	89-96	aryl hydrocarbon receptor	Homo sapiens	0-25
12673023-1	2003	Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity.	Dioxins	89-96	aryl hydrocarbon receptor	Homo sapiens	27-30
12673038-2	2003	In this study, we investigated the activation of the AhR by some vegetable constituents using the AhR-based bioassay for dioxins, i.e., the chemical activated luciferase gene expression (CALUX) assay.	Dioxins	121-128	aryl hydrocarbon receptor	Homo sapiens	53-56
12727795-4	2003	To our knowledge, this is the most comprehensive investigation to date designed to evaluate the key genes in the pathway, including AhR, aryl hydrocarbon receptor nuclear translocator, CYP1A1 and CYP1B1 transcripts and CYP1A1-associated 7-ethoxyresorufin O-deethylase (EROD) activity in a population heavily exposed to dioxin.	Dioxins	319-325	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	137-183
12621046-2	2003	Essential steps in this adaptive mechanism include AHR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor to dioxin-responsive elements (DREs) upstream of promoters that regulate the expression of genes involved in xenobiotic metabolism.	Dioxins	249-255	aryl-hydrocarbon receptor	Mus musculus	51-54
12586752-1	2003	Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	66-91
12586752-1	2003	Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	93-96
12586752-1	2003	Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions.	Dioxins	0-7	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	98-144
12586752-1	2003	Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions.	Dioxins	0-7	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	146-150
12627635-0	2003	The use of carbon thirteen nuclear magnetic resonance spectra to predict dioxin and furan binding affinities to the aryl hydrocarbon receptor.	Dioxins	73-79	aryl hydrocarbon receptor	Homo sapiens	116-141
12642156-3	2003	The two non-ortho (dioxin-like) PCBs, PCB 126 and PCB 77, showed anti-androgenic properties.	Dioxins	19-25	pyruvate carboxylase	Homo sapiens	32-35
12642156-3	2003	The two non-ortho (dioxin-like) PCBs, PCB 126 and PCB 77, showed anti-androgenic properties.	Dioxins	19-25	pyruvate carboxylase	Homo sapiens	38-41
12644593-0	2003	Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.	Dioxins	185-191	aryl-hydrocarbon receptor	Mus musculus	142-167
12604351-1	2003	The dioxin/aryl hydrocarbon (Ah) receptor functions as a ligand-activated transcription factor that mediates toxicity of dioxins and related environmental pollutants.	Dioxins	121-128	aryl-hydrocarbon receptor	Mus musculus	4-41
12646511-0	2003	Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.	Dioxins	203-210	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-28
12646511-0	2003	Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.	Dioxins	203-210	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	174-180
12646511-1	2003	The expression level of mRNAs for cytochrome P450 (CYP) 1A1 and 1B1 in freshly prepared white cells from 72 subjects exposed to dioxins at waste incinerators was investigated.	Dioxins	128-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-67
12646511-2	2003	The amounts of CYP1B1 mRNA ranged from 0.16 to 671 molecules/10(7) molecules of 18S rRNA, whereas the amounts of CYP1A1 mRNA were <6 molecules/10 ng total RNA, indicating that CYP1A1 was not induced to a detectable level by environmentally exposed dioxins.	Dioxins	251-258	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	179-185
12646511-3	2003	The inducibility of CYP1B1 mRNA in leukocytes, defined as the ratio of CYP1B1 mRNA to the plasma concentration of dioxins, varied among the subjects.	Dioxins	114-121	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	20-26
12646511-5	2003	The amounts of CYP1B1 mRNA in leukocytes of the intermediate and high responders were highly correlated with the plasma concentrations of dioxins (P < 0.05 and <0.01).	Dioxins	138-145	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	15-21
12646511-6	2003	These results suggest that CYP1B1 with polymorphic inducibility by dioxins is involved in aromatic hydrocarbon hydroxylase activities in human lymphocytes.	Dioxins	67-74	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33
12649045-9	2003	The results support our previous concept of two different AHR-mediated signaling pathways leading to dioxin type I and type II endpoints.	Dioxins	101-107	aryl hydrocarbon receptor	Rattus norvegicus	58-61
12628580-8	2003	In addition, PCB52 inhibited TCDD-induced AhR DNA binding to a dioxin-responsive element.	Dioxins	63-69	pyruvate carboxylase	Mus musculus	13-18
12628580-8	2003	In addition, PCB52 inhibited TCDD-induced AhR DNA binding to a dioxin-responsive element.	Dioxins	63-69	aryl-hydrocarbon receptor	Mus musculus	42-45
12727795-4	2003	To our knowledge, this is the most comprehensive investigation to date designed to evaluate the key genes in the pathway, including AhR, aryl hydrocarbon receptor nuclear translocator, CYP1A1 and CYP1B1 transcripts and CYP1A1-associated 7-ethoxyresorufin O-deethylase (EROD) activity in a population heavily exposed to dioxin.	Dioxins	319-325	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	219-225
12559965-4	2003	The 5(") untranslated nucleotide sequences of rat, mouse, and human T-cadherin contain a conserved GCGTG motif which constitutes the invariant core sequence of dioxin- or xenobiotic-regulatory elements.	Dioxins	160-166	cadherin 13	Homo sapiens	68-78
12663056-0	2003	Up-regulation of methionine-enkephalin-like immunoreactivity by 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the forebrain of the Long-Evans rat.	Dioxins	93-99	proenkephalin	Rattus norvegicus	28-38
12413795-2	2003	Some of these pollutants, such as polychlorinated biphenyls and dioxins, are known to induce expression of the CYP1A subfamily of genes.	Dioxins	64-71	cytochrome P450, family 1, subfamily A	Salmo salar	111-116
12787599-4	2003	Principal component analysis indicates that the main source of dioxins in bottom sediment from the back of bay are herbicides such as CNP, while in the front of bay atmospheric deposition due to incineration activities are responsible.	Dioxins	63-70	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	134-137
12464257-0	2003	Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins.	Dioxins	22-28	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	32-38
12464257-0	2003	Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins.	Dioxins	118-125	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	32-38
12464257-2	2003	In substrate specificity and reaction specificity, considerable species differences between rats and humans were observed in both CYP1A1- and CYP1A2-dependent metabolism of dioxins.	Dioxins	173-180	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-136
12464257-2	2003	In substrate specificity and reaction specificity, considerable species differences between rats and humans were observed in both CYP1A1- and CYP1A2-dependent metabolism of dioxins.	Dioxins	173-180	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
12464257-4	2003	To reveal the mechanism of dioxin metabolism, we examined rat CYP1A1-dependent metabolism of 2-chloro-dibenzo-p-dioxin.	Dioxins	27-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-68
12464257-8	2003	The metabolic pathways contain most of the metabolites observed in vivo using experimental animals, suggesting that P450 monooxygenase systems including CYP1A1 are greatly responsible for dioxin metabolism in vivo.	Dioxins	188-194	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	153-159
14501033-1	2003	The aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, is the receptor for the polycyclic aromatic hydrocarbons found in tobacco smoke, polychlorinated biphenyls, and the environmental pollutant, dioxin.	Dioxins	219-225	aryl-hydrocarbon receptor	Mus musculus	4-29
14501033-1	2003	The aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, is the receptor for the polycyclic aromatic hydrocarbons found in tobacco smoke, polychlorinated biphenyls, and the environmental pollutant, dioxin.	Dioxins	219-225	aryl-hydrocarbon receptor	Mus musculus	31-34
12505299-1	2002	The dioxin (Aryl hydrocarbon) receptor (DR) is a unique bHLH transcription factor which is activated by binding of planar aromatic hydrocarbons typified by dioxin (TCDD).	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	12-38
12200463-0	2002	Dioxin stimulates RANTES expression in an in-vitro model of endometriosis.	Dioxins	0-6	C-C motif chemokine ligand 5	Homo sapiens	18-24
12485607-1	2002	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) activates the aryl hydrocarbon receptor (AhR) to mediate transcriptional activity of dioxin-responsive genes.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	57-82
12485607-1	2002	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) activates the aryl hydrocarbon receptor (AhR) to mediate transcriptional activity of dioxin-responsive genes.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	84-87
12485607-3	2002	Cotransfection of exogenous hAhR into BP8 cells with isolated subdomains of hAhR TAD fused to glutathione S-transferase exhibited squelching of TCDD-dependent dioxin-response element (DRE)-driven luciferase reporter-gene activity with each subdomain.	Dioxins	159-165	aryl hydrocarbon receptor	Homo sapiens	28-32
12485607-3	2002	Cotransfection of exogenous hAhR into BP8 cells with isolated subdomains of hAhR TAD fused to glutathione S-transferase exhibited squelching of TCDD-dependent dioxin-response element (DRE)-driven luciferase reporter-gene activity with each subdomain.	Dioxins	159-165	aryl hydrocarbon receptor	Homo sapiens	76-80
12215427-5	2002	Transfection of Nedd8 into a cell line stably transfected with a dioxin response element linked to a chloramphenicol acetyltransferase reporter gene demonstrated that Nedd8 amplified ligand-induced transcription.	Dioxins	65-71	neural precursor cell expressed, developmentally down-regulated gene 8	Mus musculus	16-21
12215427-5	2002	Transfection of Nedd8 into a cell line stably transfected with a dioxin response element linked to a chloramphenicol acetyltransferase reporter gene demonstrated that Nedd8 amplified ligand-induced transcription.	Dioxins	65-71	neural precursor cell expressed, developmentally down-regulated gene 8	Mus musculus	167-172
12398935-7	2002	Whereas dioxin caused a rise in succinate-stimulated mitochondrial H(2)O(2) production in the wt, Cyp1a1(-/-), and Cyp1a2(-/-) mice, this increase did not occur with the Ahr(-/-) knockout.	Dioxins	8-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	98-104
12398935-7	2002	Whereas dioxin caused a rise in succinate-stimulated mitochondrial H(2)O(2) production in the wt, Cyp1a1(-/-), and Cyp1a2(-/-) mice, this increase did not occur with the Ahr(-/-) knockout.	Dioxins	8-14	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	115-121
12398935-7	2002	Whereas dioxin caused a rise in succinate-stimulated mitochondrial H(2)O(2) production in the wt, Cyp1a1(-/-), and Cyp1a2(-/-) mice, this increase did not occur with the Ahr(-/-) knockout.	Dioxins	8-14	aryl-hydrocarbon receptor	Mus musculus	170-173
12487371-2	2002	The most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induces SOD1 in human liver cells.	Dioxins	15-21	superoxide dismutase 1	Homo sapiens	75-79
12487371-7	2002	These results also imply that the SOD1 can be induced by dioxin either in combination with or independently of these two regulatory elements to effectively defend cells from oxidative stress.	Dioxins	57-63	superoxide dismutase 1	Homo sapiens	34-38
12376470-9	2002	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced expression of CYP1B1 in MCF-7 cells is increased by Trx-1.	Dioxins	29-35	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	73-79
12376470-9	2002	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced expression of CYP1B1 in MCF-7 cells is increased by Trx-1.	Dioxins	29-35	thioredoxin	Homo sapiens	111-116
12193573-1	2002	3-Methylcholanthrene (3MC) is a ligand for arylhydrocarbon receptor (AhR), which binds dioxin.	Dioxins	87-93	aryl-hydrocarbon receptor	Mus musculus	43-67
12193573-1	2002	3-Methylcholanthrene (3MC) is a ligand for arylhydrocarbon receptor (AhR), which binds dioxin.	Dioxins	87-93	aryl-hydrocarbon receptor	Mus musculus	69-72
12398935-10	2002	Dioxin treatment increased mitochondrial glutathione levels in the wt, Cyp1a1(-/-), and Cyp1a2(-/-) mice, but not in Ahr(-/-) mice.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	71-77
12398935-10	2002	Dioxin treatment increased mitochondrial glutathione levels in the wt, Cyp1a1(-/-), and Cyp1a2(-/-) mice, but not in Ahr(-/-) mice.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	88-94
12398935-11	2002	These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2.	Dioxins	49-55	aryl-hydrocarbon receptor	Mus musculus	142-145
12398935-11	2002	These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2.	Dioxins	49-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	191-197
12398935-11	2002	These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2.	Dioxins	49-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	201-207
12200463-3	2002	The biochemical effects of dioxins are mediated by binding to aryl hydrocarbon receptors (AhR).	Dioxins	27-34	aryl hydrocarbon receptor	Homo sapiens	62-88
12200463-3	2002	The biochemical effects of dioxins are mediated by binding to aryl hydrocarbon receptors (AhR).	Dioxins	27-34	aryl hydrocarbon receptor	Homo sapiens	90-93
12200463-10	2002	This study has demonstrated that functional AhR are present in endometrial and endometriotic stromal cells and that TCDD up-regulates the expression of RANTES, providing a possible mechanistic link between dioxin exposure and chemokine expression in endometriosis.	Dioxins	206-212	aryl hydrocarbon receptor	Homo sapiens	44-47
12200463-10	2002	This study has demonstrated that functional AhR are present in endometrial and endometriotic stromal cells and that TCDD up-regulates the expression of RANTES, providing a possible mechanistic link between dioxin exposure and chemokine expression in endometriosis.	Dioxins	206-212	C-C motif chemokine ligand 5	Homo sapiens	152-158
12215666-1	2002	Determination of dioxin-like compounds utilizing in vitro bioassays such as ethoxyresorufin-O-deethylase (EROD) or chemical-activated luciferase expression (DR-CALUX) is an important tool to evaluate their Ah receptor-mediated toxic effects.	Dioxins	17-23	aryl hydrocarbon receptor	Rattus norvegicus	206-217
12130674-8	2002	zfAHR2 can dimerize with zfARNT2b and binds with specificity to dioxin-responsive elements (DREs).	Dioxins	64-70	aryl hydrocarbon receptor 2	Danio rerio	0-6
12130674-10	2002	In COS-7 cells expressing zfARNT2b and zfAHR2, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure leads to a significant induction of dioxin-responsive reporter genes.	Dioxins	76-82	aryl-hydrocarbon receptor nuclear translocator 2	Danio rerio	26-34
12130674-10	2002	In COS-7 cells expressing zfARNT2b and zfAHR2, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure leads to a significant induction of dioxin-responsive reporter genes.	Dioxins	76-82	aryl hydrocarbon receptor 2	Danio rerio	39-45
12107286-3	2002	Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor.	Dioxins	114-121	aryl-hydrocarbon receptor	Mus musculus	78-81
12139968-6	2002	Transient cotransfections of mammalian cells (Hepa1c1c7, MCF-7, and BG-1) with SMRT and a TCDD-inducible luciferase reporter containing the dioxin-responsive domain from the mouse CYP1A1 regulatory region revealed that SMRT does not repress, but enhances, AhR signaling.	Dioxins	140-146	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	180-186
12139968-6	2002	Transient cotransfections of mammalian cells (Hepa1c1c7, MCF-7, and BG-1) with SMRT and a TCDD-inducible luciferase reporter containing the dioxin-responsive domain from the mouse CYP1A1 regulatory region revealed that SMRT does not repress, but enhances, AhR signaling.	Dioxins	140-146	nuclear receptor co-repressor 2	Mus musculus	219-223
12139968-6	2002	Transient cotransfections of mammalian cells (Hepa1c1c7, MCF-7, and BG-1) with SMRT and a TCDD-inducible luciferase reporter containing the dioxin-responsive domain from the mouse CYP1A1 regulatory region revealed that SMRT does not repress, but enhances, AhR signaling.	Dioxins	140-146	aryl-hydrocarbon receptor	Mus musculus	256-259
12062155-14	2002	The characteristics of the AHR potentially can be used as a biomarker of susceptibility to dioxin-like compounds, contributing to the assessment of the risk of these compounds to marine mammals and other protected animals.	Dioxins	91-97	aryl-hydrocarbon receptor	Mus musculus	27-30
12193254-5	2002	Dioxins and polychlorinated biphenyls bind to the aryl hydrocarbon receptor, phenobarbital binds to the constitutive androstane receptor and peroxisome proliferators act via the their activated receptor alpha.	Dioxins	0-7	aryl-hydrocarbon receptor	Mus musculus	50-75
12049406-6	2002	The most toxic HAHs (dioxin-like compounds) act through an intracellular receptor protein, the aryl hydrocarbon receptor, which is present in humans and many, but not all, marine animals.	Dioxins	21-27	aryl hydrocarbon receptor	Homo sapiens	95-120
11805120-1	2002	The dioxin (aryl hydrocarbon) receptor is a ligand inducible transcription factor, which mediates cellular responses to a variety of xenobiotic compounds such as dioxins.	Dioxins	162-169	aryl hydrocarbon receptor	Homo sapiens	4-38
11993628-0	2002	Dioxin reservoirs in southern Viet Nam--a legacy of Agent Orange.	Dioxins	0-6	SH3 and cysteine rich domain 3	Homo sapiens	35-38
11883943-0	2002	Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.	Dioxins	0-6	scinderin	Mus musculus	15-24
11883943-0	2002	Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	99-124
11949948-3	2002	Dioxin-like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	78-103
12030840-8	2002	Treatment with dioxin, 24 h prior to ABP, decreased methemoglobin levels by about half at each of the time points in both the Cyp1a2(-/-) and Cyp1a2(+/+) mice.	Dioxins	15-21	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	126-132
12030840-8	2002	Treatment with dioxin, 24 h prior to ABP, decreased methemoglobin levels by about half at each of the time points in both the Cyp1a2(-/-) and Cyp1a2(+/+) mice.	Dioxins	15-21	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	142-148
12071573-3	2002	Several possible levels of interaction between the dioxin and the retinoid signaling pathways are discussed, including the involvement of the Ah receptor, altered retinoic acid homeostasis, and an altered set point for retinoid storage.	Dioxins	51-57	aryl hydrocarbon receptor	Homo sapiens	142-153
12068950-0	2002	Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth.	Dioxins	31-37	aryl-hydrocarbon receptor	Mus musculus	48-73
12068950-0	2002	Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth.	Dioxins	31-37	aryl-hydrocarbon receptor	Mus musculus	75-78
12068950-0	2002	Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth.	Dioxins	31-37	aryl hydrocarbon receptor nuclear translocator	Mus musculus	88-112
12068950-0	2002	Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth.	Dioxins	31-37	aryl hydrocarbon receptor nuclear translocator	Mus musculus	114-118
12068950-4	2002	The aryl hydrocarbon receptor (AHR) together with the AHR nuclear translocator (ARNT) protein is believed to mediate the toxic effects of dioxins.	Dioxins	138-145	aryl-hydrocarbon receptor	Mus musculus	4-29
12068950-4	2002	The aryl hydrocarbon receptor (AHR) together with the AHR nuclear translocator (ARNT) protein is believed to mediate the toxic effects of dioxins.	Dioxins	138-145	aryl-hydrocarbon receptor	Mus musculus	31-34
12068950-4	2002	The aryl hydrocarbon receptor (AHR) together with the AHR nuclear translocator (ARNT) protein is believed to mediate the toxic effects of dioxins.	Dioxins	138-145	aryl hydrocarbon receptor nuclear translocator	Mus musculus	54-78
12068950-4	2002	The aryl hydrocarbon receptor (AHR) together with the AHR nuclear translocator (ARNT) protein is believed to mediate the toxic effects of dioxins.	Dioxins	138-145	aryl hydrocarbon receptor nuclear translocator	Mus musculus	80-84
11809848-4	2002	The induction of mouse CYP2S1 mRNA by dioxin represents a primary response and required the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins.	Dioxins	38-44	cytochrome P450, family 2, subfamily s, polypeptide 1	Mus musculus	23-29
11861973-0	2002	Dioxin inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-beta expression.	Dioxins	0-6	proliferating cell nuclear antigen	Mus musculus	95-101
11854449-0	2002	Non-ahr gene susceptibility Loci for porphyria and liver injury induced by the interaction of "dioxin" with iron overload in mice.	Dioxins	95-101	aryl-hydrocarbon receptor	Mus musculus	4-7
11854449-3	2002	Evidence is consistent with the actions of dioxin being mediated through binding to the aryl hydrocarbon receptor (AHR) with different Ahr alleles in mouse strains apparently accounting for differential downstream gene expression and susceptibility.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	88-113
11854449-3	2002	Evidence is consistent with the actions of dioxin being mediated through binding to the aryl hydrocarbon receptor (AHR) with different Ahr alleles in mouse strains apparently accounting for differential downstream gene expression and susceptibility.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	115-118
11854449-3	2002	Evidence is consistent with the actions of dioxin being mediated through binding to the aryl hydrocarbon receptor (AHR) with different Ahr alleles in mouse strains apparently accounting for differential downstream gene expression and susceptibility.	Dioxins	43-49	aryl-hydrocarbon receptor	Mus musculus	135-138
11854449-10	2002	These findings show for the first time the location of genes, other than Ahr, that modulate the mechanism of hepatic porphyria and injury caused by dioxin in mice.	Dioxins	148-154	aryl-hydrocarbon receptor	Mus musculus	73-76
11809848-4	2002	The induction of mouse CYP2S1 mRNA by dioxin represents a primary response and required the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins.	Dioxins	38-44	aryl-hydrocarbon receptor	Mus musculus	92-117
11809848-4	2002	The induction of mouse CYP2S1 mRNA by dioxin represents a primary response and required the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins.	Dioxins	38-44	aryl-hydrocarbon receptor	Mus musculus	122-147
11809858-3	2002	AhR is a cytosolic ligand-dependent transcription factor that, in conjunction with the AhR nuclear translocator (Arnt), binds to dioxin response elements (DREs) located in the promoter region of target genes, such as CYP1A1, and induces their transcription.	Dioxins	129-135	aryl hydrocarbon receptor	Homo sapiens	0-3
11809858-3	2002	AhR is a cytosolic ligand-dependent transcription factor that, in conjunction with the AhR nuclear translocator (Arnt), binds to dioxin response elements (DREs) located in the promoter region of target genes, such as CYP1A1, and induces their transcription.	Dioxins	129-135	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	87-111
11809858-3	2002	AhR is a cytosolic ligand-dependent transcription factor that, in conjunction with the AhR nuclear translocator (Arnt), binds to dioxin response elements (DREs) located in the promoter region of target genes, such as CYP1A1, and induces their transcription.	Dioxins	129-135	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	113-117
11809858-3	2002	AhR is a cytosolic ligand-dependent transcription factor that, in conjunction with the AhR nuclear translocator (Arnt), binds to dioxin response elements (DREs) located in the promoter region of target genes, such as CYP1A1, and induces their transcription.	Dioxins	129-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	217-223
11896663-0	2002	The Belgian PCB/dioxin incident: analysis of the food chain contamination and health risk evaluation.	Dioxins	16-22	pyruvate carboxylase	Bos taurus	12-15
11790108-1	2002	The Ah receptor is a ligand-dependent transcription factor that mediates the biological and toxic effects of polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	217-223	aryl-hydrocarbon receptor	Mus musculus	4-15
12481307-4	2002	However, an endogenous role for AhR in development and homeostasis is supported by (1) the discovery of low affinity, endogenous ligands; (2) studies demonstrating a role for the receptor in development of liver and vascular systems, that were established using mice lacking AhR expression; and (3) the presence of functional dioxin-responsive elements in promoter regions of genes involved in cellular growth and differentiation.	Dioxins	326-332	aryl-hydrocarbon receptor	Mus musculus	32-35
12362388-6	2002	The method allows the chromatographic separation of at least 35 congeners and can therefore be applied to the routine monitoring of the general population for both dioxin-like and non-dioxin-like PCB congeners.	Dioxins	184-190	pyruvate carboxylase	Homo sapiens	196-199
11835227-3	2002	The effects of dioxins are mediated via the aryl hydrocarbon receptor (AHR) and its binding protein, aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	15-22	aryl hydrocarbon receptor	Homo sapiens	44-69
11835227-3	2002	The effects of dioxins are mediated via the aryl hydrocarbon receptor (AHR) and its binding protein, aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	15-22	aryl hydrocarbon receptor	Homo sapiens	71-74
11835227-3	2002	The effects of dioxins are mediated via the aryl hydrocarbon receptor (AHR) and its binding protein, aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	15-22	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	101-147
11835227-3	2002	The effects of dioxins are mediated via the aryl hydrocarbon receptor (AHR) and its binding protein, aryl hydrocarbon receptor nuclear translocator (ARNT).	Dioxins	15-22	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	149-153
11835227-11	2002	CONCLUSIONS: Homozygosity for the 185Pro allele of AHRR may increase the susceptibility of a fetus to the undermasculinizing effects of dioxin exposure in utero, presumably through the diminished inhibition of AHR-mediated signaling.	Dioxins	136-142	aryl hydrocarbon receptor repressor	Homo sapiens	51-55
11835227-11	2002	CONCLUSIONS: Homozygosity for the 185Pro allele of AHRR may increase the susceptibility of a fetus to the undermasculinizing effects of dioxin exposure in utero, presumably through the diminished inhibition of AHR-mediated signaling.	Dioxins	136-142	aryl hydrocarbon receptor	Homo sapiens	51-54
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-52
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	54-60
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	63-69
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	prohibitin 2	Mus musculus	238-241
11755109-0	2001	In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model.	Dioxins	94-100	aryl hydrocarbon receptor	Rattus norvegicus	25-50
11731439-2	2001	The intracellular Ah receptor, a ligand-dependent transcription factor of the basic region/helix-loop-helix/Per-Ahr/Arnt-Sim homology domain (bHLH-PAS) protein family, mediates responses to dioxins.	Dioxins	190-197	aryl hydrocarbon receptor	Homo sapiens	18-29
11731439-3	2001	Target genes of the Ah receptor that mediate dioxin toxicity and carcinogenicity are, however, mostly unknown.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	20-31
11731439-6	2001	N-myristoyltransferase 2 (NMT2) is one of the later dioxin-inducible genes.	Dioxins	52-58	N-myristoyltransferase 2	Homo sapiens	0-24
11731439-6	2001	N-myristoyltransferase 2 (NMT2) is one of the later dioxin-inducible genes.	Dioxins	52-58	N-myristoyltransferase 2	Homo sapiens	26-30
11731439-11	2001	Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity.	Dioxins	147-153	N-myristoyltransferase 2	Homo sapiens	115-119
11748833-1	2001	Induction patterns of cytochrome P4501A1 (CYP1A1), an early biochemical marker of exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) were investigated during zebrafish (Danio rerio) development.	Dioxins	150-156	cytochrome P450, family 1, subfamily A	Danio rerio	22-40
11748833-1	2001	Induction patterns of cytochrome P4501A1 (CYP1A1), an early biochemical marker of exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) were investigated during zebrafish (Danio rerio) development.	Dioxins	150-156	cytochrome P450, family 1, subfamily A	Danio rerio	42-48
11728448-0	2001	Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis.	Dioxins	0-6	gametogenetin binding protein 2	Homo sapiens	39-44
11551916-1	2001	The aryl hydrocarbon receptor (AhR), a basic helix-loop-helix/Per-Arnt-Sim transcription factor, mediates many of the toxic and biological effects of the environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin, which include the transcriptional activation of dioxin-responsive genes such as CYP1A1.	Dioxins	210-216	aryl hydrocarbon receptor	Homo sapiens	4-29
11551916-1	2001	The aryl hydrocarbon receptor (AhR), a basic helix-loop-helix/Per-Arnt-Sim transcription factor, mediates many of the toxic and biological effects of the environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin, which include the transcriptional activation of dioxin-responsive genes such as CYP1A1.	Dioxins	210-216	aryl hydrocarbon receptor	Homo sapiens	31-34
11551916-4	2001	Deletional analysis of the hAhR transactivation domain indicates that removal of the P/S/T-rich subdomain enhances transcriptional activity, whereas the Q-rich subdomain is critical for hAhR transactivation potential, and the acidic subdomain by itself fails to activate a dioxin response element-driven reporter gene.	Dioxins	273-279	aryl hydrocarbon receptor	Homo sapiens	27-31
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Dioxins	129-135	aryl-hydrocarbon receptor	Mus musculus	82-106
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Dioxins	129-135	aryl-hydrocarbon receptor	Mus musculus	108-111
11602686-0	2001	Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.	Dioxins	34-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
11606800-10	2001	In electrophoretic mobility shift assays, the beluga AHR exhibited sequence-specific, Arnt-dependent binding to a dioxin responsive enhancer (DRE).	Dioxins	114-120	aryl hydrocarbon receptor	Homo sapiens	53-56
11896663-1	2002	The Belgian PCB incident occurred at the end of January 1999 when a mixture of polychlorinated biphenyls (PCBs) contaminated with dioxins was accidentally added to a stock of recycled fat used in the production of animal feeds.	Dioxins	130-137	pyruvate carboxylase	Bos taurus	12-15
11896663-5	2002	When PCB concentrations exceeded the tolerance levels of 0.1 (milk), 0.2 (poultry, bovine, and pig meat), or 1 (animal feed) microg/g fat, dioxins (17 PCDD/Fs congeners) were also determined.	Dioxins	139-146	pyruvate carboxylase	Bos taurus	5-8
11896663-10	2002	This PCB mixture contained about 1g TEQ dioxins (more than 90- contributed by PCDFs) and about 2g TEQ dioxin-like PCBs.	Dioxins	40-47	pyruvate carboxylase	Bos taurus	5-8
11896663-10	2002	This PCB mixture contained about 1g TEQ dioxins (more than 90- contributed by PCDFs) and about 2g TEQ dioxin-like PCBs.	Dioxins	40-46	pyruvate carboxylase	Bos taurus	5-8
11737705-1	2001	BACKGROUND AND METHODS: The aim of this study was to assess the effect of lactational exposure to dioxins in neonates on the cytochrome P450 1A1 (CYP1A1) induction in the level of gene expression.	Dioxins	98-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	125-144
11585345-10	2001	The altered transactivation domain of AHR is associated with a lower sensitivity of bone to TCDD in H/W rats, suggesting that AHR plays a role in modulating the effects of dioxins on bone.	Dioxins	172-179	aryl hydrocarbon receptor	Rattus norvegicus	38-41
11585345-10	2001	The altered transactivation domain of AHR is associated with a lower sensitivity of bone to TCDD in H/W rats, suggesting that AHR plays a role in modulating the effects of dioxins on bone.	Dioxins	172-179	aryl hydrocarbon receptor	Rattus norvegicus	126-129
11737705-1	2001	BACKGROUND AND METHODS: The aim of this study was to assess the effect of lactational exposure to dioxins in neonates on the cytochrome P450 1A1 (CYP1A1) induction in the level of gene expression.	Dioxins	98-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	146-152
11516172-2	2001	In present work CYP1A1 mRNA was induced in a variety of cultured rat epithelial cells by suspension, but the induction was transient, with CYP1A1 mRNA reaching maximal levels by 5 h and disappearing by 12 h. Though the methylcellulose itself contained no detectable ligand, (a) suspension activated the AhR, as judged by mobility shift assays, (b) the AhR competitive inhibitor alpha-naphthoflavone inhibited suspension-mediated induction, and (c) induction was dependent upon dioxin responsive transcriptional elements in the CYP1A1 promoter.	Dioxins	477-483	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-22
11783634-2	2001	Using these values, release/inflow ratios of dioxin-like PCB congeners (ratio of the amount released from the incinerator to the amount flowing into the incinerator through waste) were calculated.	Dioxins	45-51	pyruvate carboxylase	Homo sapiens	57-60
11783634-7	2001	Deposition of dioxin-like PCB congeners 81, 126, 169, and 189 were also found in amounts similar to those released via the waste incinerator emissions.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	26-29
11478770-0	2001	The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor.	Dioxins	28-34	aryl hydrocarbon receptor	Cavia porcellus	4-15
11595506-4	2001	Although the mechanism of endocrine disruption is not clear, the actions of dioxins are known to be mediated by binding to the arylhydrocarbon receptor (AhR), and it is known that dioxins act as transcription factors to endocrine-associated gene expression.	Dioxins	76-83	aryl hydrocarbon receptor	Homo sapiens	127-151
11595506-4	2001	Although the mechanism of endocrine disruption is not clear, the actions of dioxins are known to be mediated by binding to the arylhydrocarbon receptor (AhR), and it is known that dioxins act as transcription factors to endocrine-associated gene expression.	Dioxins	76-83	aryl hydrocarbon receptor	Homo sapiens	153-156
11595506-4	2001	Although the mechanism of endocrine disruption is not clear, the actions of dioxins are known to be mediated by binding to the arylhydrocarbon receptor (AhR), and it is known that dioxins act as transcription factors to endocrine-associated gene expression.	Dioxins	180-187	aryl hydrocarbon receptor	Homo sapiens	153-156
11589571-2	2001	Here we have investigated the effect of the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on the promoter of the Cu/Zn superoxide dismutase (SOD1) gene in HepG2 and HeLa cells using the chloramphenicol acetyltransferase gene as a reporter.	Dioxins	55-61	superoxide dismutase 1	Homo sapiens	158-162
11589571-9	2001	The induced SOD1 may accelerate the neutralization of the superoxide anion and thus reduce the oxidative damage associated with dioxin toxicity.	Dioxins	128-134	superoxide dismutase 1	Homo sapiens	12-16
11509025-0	2001	Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effect on aryl hydrocarbon receptor expression in a dioxin-resistance model.	Dioxins	50-56	aryl hydrocarbon receptor	Rattus norvegicus	77-102
11509025-3	2001	Since environmental exposure to dioxins is typically of a repeated low-dose nature, we examined the effect of such exposure on AHR expression.	Dioxins	32-39	aryl hydrocarbon receptor	Rattus norvegicus	127-130
11478770-0	2001	The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor.	Dioxins	28-34	aryl hydrocarbon receptor	Homo sapiens	100-111
11478770-7	2001	The closest homolog of the Guinea pig receptor turned out to be the human AHR, which may be relevant for dioxin risk assessment.	Dioxins	105-111	aryl hydrocarbon receptor	Homo sapiens	74-77
11683414-0	2001	Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin.	Dioxins	164-170	aryl-hydrocarbon receptor	Mus musculus	0-24
11479202-0	2001	Dioxin suppresses the checkpoint protein, MAD2, by an aryl hydrocarbon receptor-independent pathway.	Dioxins	0-6	mitotic arrest deficient 2 like 1	Homo sapiens	42-46
11683414-0	2001	Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin.	Dioxins	164-170	aryl-hydrocarbon receptor	Mus musculus	26-29
11455387-5	2001	The Ahr is also activated by dioxin, one of the most intensively studied environmental contaminants.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	4-7
11455387-8	2001	Oocytes microinjected with a Bax promoter-reporter construct show Ahr-dependent transcriptional activation after PAH, but not dioxin, treatment, consistent with findings that dioxin is not cytotoxic to oocytes.	Dioxins	175-181	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32
11455387-8	2001	Oocytes microinjected with a Bax promoter-reporter construct show Ahr-dependent transcriptional activation after PAH, but not dioxin, treatment, consistent with findings that dioxin is not cytotoxic to oocytes.	Dioxins	175-181	aryl hydrocarbon receptor	Homo sapiens	66-69
11455387-9	2001	This difference in the action of PAHs versus dioxin is conveyed by a single base pair flanking each Ahr response element in the Bax promoter.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	100-103
11455387-9	2001	This difference in the action of PAHs versus dioxin is conveyed by a single base pair flanking each Ahr response element in the Bax promoter.	Dioxins	45-51	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Dioxins	58-64	pyruvate carboxylase	Homo sapiens	70-73
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	175-186
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Dioxins	58-64	aryl hydrocarbon receptor	Homo sapiens	214-225
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Dioxins	89-95	pyruvate carboxylase	Homo sapiens	70-73
11394885-3	2001	HIF-1beta is associated with HIF-1 functions as a dimerization partner of HIF-1alpha, and is on the other hand associated with carcinogenesis via dioxin signaling.	Dioxins	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	30-33
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	99-124
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	126-129
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	126-129
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	175-208
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	210-214
11469723-4	2001	Mechanistic studies reveal an AhR/DRE paradigm for the induction, which involves activation of the aryl hydrocarbon receptor (AhR) by an agonist, dimerization of AhR with the Ah recceptor nuclear translocator (Arnt), followed by binding of the AhR/Arnt heterodimer to the dioxin-responsive enhancer (DRE) and transcription of the gene.	Dioxins	272-278	aryl hydrocarbon receptor	Homo sapiens	126-129
11469723-6	2001	In addition to CYP1A1 induction, AhR mediates a broad range of biological responses to CYP1A1 inducers, typified by the environmental contaminant dioxin, via modulating gene expression.	Dioxins	146-152	aryl hydrocarbon receptor	Homo sapiens	33-36
11469723-6	2001	In addition to CYP1A1 induction, AhR mediates a broad range of biological responses to CYP1A1 inducers, typified by the environmental contaminant dioxin, via modulating gene expression.	Dioxins	146-152	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
11469723-7	2001	Thus, mechanistic studies of CYP1A1 induction have provided insights into P450 induction, PAH carcinogenesis, dioxin action, AhR function, and receptor-mediated mammalian gene expression.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
11375377-3	2001	Increased blood levels of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin), a PCB-like compound, have recently been reported among subjects with diabetes, suggesting that PCB levels could be similarly elevated.	Dioxins	26-32	pyruvate carboxylase	Homo sapiens	74-77
11375377-3	2001	Increased blood levels of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin), a PCB-like compound, have recently been reported among subjects with diabetes, suggesting that PCB levels could be similarly elevated.	Dioxins	26-32	pyruvate carboxylase	Homo sapiens	167-170
14961319-4	2001	Much of this work is focused on the aryl hydrocarbon receptor (AHR), a ligand-activated, bHLH-PAS transcription factor through which dioxins cause altered gene expression and toxicity.	Dioxins	133-140	aryl hydrocarbon receptor	Homo sapiens	63-66
11453109-0	2001	Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	0-25
11453109-0	2001	Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells.	Dioxins	120-126	aryl hydrocarbon receptor	Homo sapiens	27-30
14961319-5	2001	In contrast to mammals, which appear to express a single dioxin-binding AHR, many fish species possess at least two AHR genes.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	72-75
14961319-6	2001	Studies of these two fish AHRs may help to reveal the multiple functions of the single mammalian "AHR," its physiological ligand, and the molecular mechanisms involved in differential sensitivity to dioxin-like compounds.	Dioxins	199-205	aryl hydrocarbon receptor	Homo sapiens	26-29
11407940-8	2001	For dioxin-like compounds, using a surrogate marker of response CYP1A1 induction, this approach yields an estimate of the acceptable daily intake of 5-50 fg/kg/day.	Dioxins	4-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
11339810-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	4-29
11339810-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics.	Dioxins	109-115	aryl hydrocarbon receptor	Homo sapiens	31-34
11339810-3	2001	We investigated how AhR is retained in the cytosol and how dioxin induces AhR to move to the nucleus.	Dioxins	59-65	aryl hydrocarbon receptor	Homo sapiens	74-77
11339810-6	2001	Dioxin treatment caused a more rapid accumulation of AhR in the nucleus than LMB treatment.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	53-56
11339810-7	2001	In the presence of both dioxin and LMB, nuclear accumulation of AhR was more rapid than in the presence of dioxin alone.	Dioxins	24-30	aryl hydrocarbon receptor	Homo sapiens	64-67
11339810-7	2001	In the presence of both dioxin and LMB, nuclear accumulation of AhR was more rapid than in the presence of dioxin alone.	Dioxins	107-113	aryl hydrocarbon receptor	Homo sapiens	64-67
11358810-0	2001	Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.	Dioxins	75-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	27-54
11174852-3	2001	TCDD inhibited E2-induced Hsp 27 gene expression and analysis of the Hsp 27 gene promoter showed that the inhibitory response was associated with AhR interactions with a pentanucleotide motif at -3 to +2 in the promoter that corresponded to the core sequence of a dioxin responsive element.	Dioxins	264-270	heat shock protein family B (small) member 1	Homo sapiens	69-75
11369115-2	2001	The model included induction of P450 isozymes and suggested the presence of multiple binding sites with different affinities for the TCDD-liganded Ah receptor at CYP1A1 dioxin responsive elements.	Dioxins	169-175	aryl hydrocarbon receptor	Rattus norvegicus	147-158
11369115-2	2001	The model included induction of P450 isozymes and suggested the presence of multiple binding sites with different affinities for the TCDD-liganded Ah receptor at CYP1A1 dioxin responsive elements.	Dioxins	169-175	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	162-168
11369115-11	2001	The poorer induction of CYP1B1 was predicted to be due to lower affinity of the dioxin responsive elements for binding the liganded Ah receptor, suggesting the involvement of other regulatory factors, and a shorter poly(A) tail on CYP1B1 mRNA, leading to a shorter lifetime.	Dioxins	80-86	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	24-30
11369115-11	2001	The poorer induction of CYP1B1 was predicted to be due to lower affinity of the dioxin responsive elements for binding the liganded Ah receptor, suggesting the involvement of other regulatory factors, and a shorter poly(A) tail on CYP1B1 mRNA, leading to a shorter lifetime.	Dioxins	80-86	aryl hydrocarbon receptor	Rattus norvegicus	132-143
11239493-3	2001	The CYP1A1 gene is highly inducible by the environmental contaminants dioxin and benzo[a]pyrene.	Dioxins	70-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-10
11333188-3	2001	Dioxin measurements showed a clear predominance of polychlorinated dibenzofuran over polychlorinated dibenzodioxin congeners, a dioxin/PCB ratio of approximately 1:50,000 and a PCB fingerprint resembling that of an Aroclor mixture, thus confirming contamination by transformer oil rather than by other environmental sources.	Dioxins	0-6	pyruvate carboxylase	Bos taurus	135-138
11333188-3	2001	Dioxin measurements showed a clear predominance of polychlorinated dibenzofuran over polychlorinated dibenzodioxin congeners, a dioxin/PCB ratio of approximately 1:50,000 and a PCB fingerprint resembling that of an Aroclor mixture, thus confirming contamination by transformer oil rather than by other environmental sources.	Dioxins	0-6	pyruvate carboxylase	Bos taurus	177-180
11372828-2	2001	SRI is developing a continuous emissions monitor to study the emission levels of these most toxic dioxins, leading eventually to an improved understanding of the formation of these molecules and to improved means of monitoring and control.	Dioxins	98-105	sorcin	Homo sapiens	0-3
11372870-5	2001	Thus, we propose that measuring caspase-3 activation in the human T-lymphoblastic cell line, L-MAT, is a useful evaluation method for the immunotoxicity of dioxin compounds.	Dioxins	156-162	caspase 3	Homo sapiens	32-41
11323156-2	2001	The nuclear AhR complex is a heterodimer containing the AhR and AhR nuclear translocator (Arnt) proteins, and the molecular mechanism of AhR action is associated with binding of the heterodimer to dioxin responsive elements (DREs) in regulatory regions of Ah-responsive genes.	Dioxins	197-203	aryl hydrocarbon receptor	Homo sapiens	12-15
11323156-2	2001	The nuclear AhR complex is a heterodimer containing the AhR and AhR nuclear translocator (Arnt) proteins, and the molecular mechanism of AhR action is associated with binding of the heterodimer to dioxin responsive elements (DREs) in regulatory regions of Ah-responsive genes.	Dioxins	197-203	aryl hydrocarbon receptor	Homo sapiens	56-59
11323156-2	2001	The nuclear AhR complex is a heterodimer containing the AhR and AhR nuclear translocator (Arnt) proteins, and the molecular mechanism of AhR action is associated with binding of the heterodimer to dioxin responsive elements (DREs) in regulatory regions of Ah-responsive genes.	Dioxins	197-203	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	64-88
11323156-2	2001	The nuclear AhR complex is a heterodimer containing the AhR and AhR nuclear translocator (Arnt) proteins, and the molecular mechanism of AhR action is associated with binding of the heterodimer to dioxin responsive elements (DREs) in regulatory regions of Ah-responsive genes.	Dioxins	197-203	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	90-94
11323156-2	2001	The nuclear AhR complex is a heterodimer containing the AhR and AhR nuclear translocator (Arnt) proteins, and the molecular mechanism of AhR action is associated with binding of the heterodimer to dioxin responsive elements (DREs) in regulatory regions of Ah-responsive genes.	Dioxins	197-203	aryl hydrocarbon receptor	Homo sapiens	56-59
11257517-7	2001	P450 enzyme activities were assessed using 8 different substrates and increases were found after treatment with phenobarbitone, rifampicin, and dioxin.	Dioxins	144-150	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4
11165043-2	2001	Analysis of the cathepsin D gene promoter initially identified a pentanucleotide GCGTG core dioxin responsive element (DRE) that blocked E2 action by inhibiting formation of a transcriptionally active estrogen receptor (ER)-Sp1 complex.	Dioxins	92-98	cathepsin D	Homo sapiens	16-27
11275356-2	2001	Some PCBs exert dioxin-like activities mediated through the aryl hydrocarbon receptor.	Dioxins	16-22	aryl hydrocarbon receptor	Homo sapiens	60-85
11042205-8	2001	The differential sensitivity of mammalian species to toxic effects of AhR ligands, especially dioxin (TCDD), correlates with the expression of 7-hydroxycholesterol dehydrogenase, which synthesizes 7-KC from 7-hydroxycholesterol.	Dioxins	94-100	aryl hydrocarbon receptor	Homo sapiens	70-73
11174852-3	2001	TCDD inhibited E2-induced Hsp 27 gene expression and analysis of the Hsp 27 gene promoter showed that the inhibitory response was associated with AhR interactions with a pentanucleotide motif at -3 to +2 in the promoter that corresponded to the core sequence of a dioxin responsive element.	Dioxins	264-270	aryl hydrocarbon receptor	Homo sapiens	146-149
11163336-4	2001	2,3,7,8-Tetrachlorodibenzo-p-dioxin (dioxin; TCDD) is known to activate Cyp1a1 gene transcription by way of aromatic hydrocarbon response elements (AHREs).	Dioxins	29-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-78
11156691-1	2001	Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes.	Dioxins	50-56	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19
11156691-1	2001	Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes.	Dioxins	50-56	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27
11163336-5	2001	We found that AG879 also prevents, to a lesser extent, the AHRE-mediated induction of CYP1A1 and NQO1 mRNA by dioxin.	Dioxins	110-116	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	86-92
11163336-5	2001	We found that AG879 also prevents, to a lesser extent, the AHRE-mediated induction of CYP1A1 and NQO1 mRNA by dioxin.	Dioxins	110-116	NAD(P)H dehydrogenase, quinone 1	Mus musculus	97-101
23886312-9	2001	These data support the use of the RGS assay to detect the presence of CYP1Ainducing compounds, including retene as well as dioxins and furans, in sediments near pulp mills.	Dioxins	123-130	paired like homeodomain 2	Homo sapiens	34-37
12213967-4	2001	In addition, dioxin exposure led to an increase in triglycerides, but not in high-density lipoproteins, in both Apoe(+/+) mice and in hyperlipidemic Apoe(-/- mice.	Dioxins	13-19	apolipoprotein E	Mus musculus	112-116
12213967-4	2001	In addition, dioxin exposure led to an increase in triglycerides, but not in high-density lipoproteins, in both Apoe(+/+) mice and in hyperlipidemic Apoe(-/- mice.	Dioxins	13-19	apolipoprotein E	Mus musculus	149-153
12213967-5	2001	Dioxin exposure also led to an increase in low-density lipoproteins in Apoe(-/-) mice.	Dioxins	0-6	apolipoprotein E	Mus musculus	71-75
12213967-8	2001	Subchronic treatment of Apoe(-/-) mice with dioxin (150 ng/kg, three times weekly) for 7 or 26 wk caused a trend toward earlier onset and greater severity of atherosclerotic lesions compared to those of vehicle treated mice.	Dioxins	44-50	apolipoprotein E	Mus musculus	24-28
11748491-2	2001	PCB 126 because of its dioxin-like configuration and high toxicity while 153 because it is one of the most commonly detected congeners in breast milk.	Dioxins	23-29	pyruvate carboxylase	Homo sapiens	0-3
11820637-1	2001	The ahr gene product is a ligand-activated transcription factor which regulates the expression of a number of enzymes involved in the metabolism of aryl hydrocarbons and mediates the effects of dioxins on tumour promotion.	Dioxins	194-201	aryl-hydrocarbon receptor	Mus musculus	4-7
11673847-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a diverse range of chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	244-250	aryl-hydrocarbon receptor	Mus musculus	4-29
11673847-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a diverse range of chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	244-250	aryl-hydrocarbon receptor	Mus musculus	31-34
11393538-1	2001	The diversity of biological effects resulting from exposure to dioxin may reflect the ability of this environmental pollutant to alter gene expression by binding to the arylhydrocarbon receptor (AHR) gene and related genes.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	169-193
11393538-1	2001	The diversity of biological effects resulting from exposure to dioxin may reflect the ability of this environmental pollutant to alter gene expression by binding to the arylhydrocarbon receptor (AHR) gene and related genes.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	195-198
11134554-3	2001	Dioxin-like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor.	Dioxins	0-6	aryl hydrocarbon receptor	Macaca mulatta	78-103
11215685-4	2001	With the growth of new knowledge about the molecular basis of dioxin actions in humans and animals, it is clear that most of the responses produced by this agent are initiated by a specific recognition protein (designated the Ah receptor) found in almost all animal and human tissues and organs.	Dioxins	62-68	aryl hydrocarbon receptor	Homo sapiens	226-237
11215685-5	2001	The recognition event between the Ah receptor and environmental agents like dioxin is due to the formation of a complex.	Dioxins	76-82	aryl hydrocarbon receptor	Homo sapiens	34-45
11215685-6	2001	We have observed that in the presence of dioxin, the Ah receptor turns off proliferation in tumor cells and suppresses the ability of these cells to invade normal tissue.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	53-64
11280988-6	2001	Studies have shown that these dioxin-like compounds can react with the aryl hydrocarbon receptor.	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	71-96
11120824-7	2000	We show here that these DNA motifs, the so-called dioxin response elements, after binding to the liganded AHR are sufficient to transactivate luciferase expression in a reporter gene system.	Dioxins	50-56	aryl-hydrocarbon receptor	Mus musculus	106-109
11156390-13	2000	Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment.	Dioxins	131-137	aryl hydrocarbon receptor	Rattus norvegicus	56-81
11133348-11	2000	These results suggest that the majority of the tumor promotion potential of PCB mixtures resides in the non-dioxin-like fraction, which is not taken into account in the toxic equivalency factor (TEF) approach for risk assessment of PCBs.	Dioxins	108-114	pyruvate carboxylase	Rattus norvegicus	76-79
11133817-0	2000	Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway.	Dioxins	67-73	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	103-108
11187750-9	2000	Estimated total TEQ intakes of chlorinated dioxins and related chemicals from the breast milk correlated negatively with the percentages of CD8 positive lymphocytes.	Dioxins	43-50	CD8a molecule	Homo sapiens	140-143
11054704-1	2000	Dioxin exposure alters a variety of neural functions, most likely through activation of the arylhydrocarbon receptor (AhR) pathway.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	92-116
11187737-5	2000	Dioxins stimulate the expression of genes(e.g. cytochrome P450 1A1 and related drug metabolizing enzymes) via a ligand dependent transactivating factor, arylhydrocarbon receptor(Ah-R).	Dioxins	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-66
11054704-1	2000	Dioxin exposure alters a variety of neural functions, most likely through activation of the arylhydrocarbon receptor (AhR) pathway.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	118-121
11054704-8	2000	The most noteworthy regions in which we found AhR, ARNT, and ARNT2 mRNA were several hypothalamic and brainstem regions involved in the regulation of appetite and circadian rhythms, functions that are disrupted by dioxin exposure.	Dioxins	214-220	aryl hydrocarbon receptor	Rattus norvegicus	46-49
11054704-8	2000	The most noteworthy regions in which we found AhR, ARNT, and ARNT2 mRNA were several hypothalamic and brainstem regions involved in the regulation of appetite and circadian rhythms, functions that are disrupted by dioxin exposure.	Dioxins	214-220	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	51-55
11054704-8	2000	The most noteworthy regions in which we found AhR, ARNT, and ARNT2 mRNA were several hypothalamic and brainstem regions involved in the regulation of appetite and circadian rhythms, functions that are disrupted by dioxin exposure.	Dioxins	214-220	aryl hydrocarbon receptor nuclear translocator 2	Rattus norvegicus	61-66
10961990-3	2000	We show here that AIP associates with AhR homologues from mouse and fish, which can bind ligands such as dioxin, but nonligand binding homologues from Caenorhabditis elegans or Drosophila do not bind to AIP.	Dioxins	105-111	aryl-hydrocarbon receptor-interacting protein	Mus musculus	18-21
10961990-3	2000	We show here that AIP associates with AhR homologues from mouse and fish, which can bind ligands such as dioxin, but nonligand binding homologues from Caenorhabditis elegans or Drosophila do not bind to AIP.	Dioxins	105-111	aryl-hydrocarbon receptor	Mus musculus	38-41
11072074-7	2000	In COS-7 cells expressing zfARNT2b and zfAhR2, 10 nM TCDD causes a nine-fold induction of a dioxin responsive reporter gene.	Dioxins	92-98	aryl-hydrocarbon receptor nuclear translocator 2	Danio rerio	26-34
11072074-7	2000	In COS-7 cells expressing zfARNT2b and zfAhR2, 10 nM TCDD causes a nine-fold induction of a dioxin responsive reporter gene.	Dioxins	92-98	aryl hydrocarbon receptor 2	Danio rerio	39-45
11072074-10	2000	DNA gel shift analysis suggests that the decreased function of zfARNT2a is due to inefficient binding of zfARNT2a/zfAhR2 complexes to dioxin responsive elements.	Dioxins	134-140	aryl-hydrocarbon receptor nuclear translocator 2	Danio rerio	63-71
11072074-10	2000	DNA gel shift analysis suggests that the decreased function of zfARNT2a is due to inefficient binding of zfARNT2a/zfAhR2 complexes to dioxin responsive elements.	Dioxins	134-140	aryl-hydrocarbon receptor nuclear translocator 2	Danio rerio	105-113
11072074-10	2000	DNA gel shift analysis suggests that the decreased function of zfARNT2a is due to inefficient binding of zfARNT2a/zfAhR2 complexes to dioxin responsive elements.	Dioxins	134-140	aryl hydrocarbon receptor 2	Danio rerio	114-120
11018766-0	2000	Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol.	Dioxins	14-20	aryl hydrocarbon receptor	Rattus norvegicus	77-102
11061999-6	2000	Transient transfection assay using dioxin-response element (DRE)-linked luciferase revealed that bisphenol A reduced transformation of the aryl hydrocarbons (Ah) receptor to a form capable of specifically binding to the DRE sequence in the promoter of the Cyp1a-1 gene.	Dioxins	35-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	256-263
11068867-0	2000	Effects of dioxin and estrogen on collagenase-3 in UMR 106-01 osteosarcoma cells.	Dioxins	11-17	matrix metallopeptidase 13	Rattus norvegicus	34-47
11006353-0	2000	Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish Fundulus heteroclitus.	Dioxins	73-79	aryl hydrocarbon receptor-like	Fundulus heteroclitus	48-52
10702233-7	2000	Mutation of the aryl hydrocarbon receptor response elements (dioxin response elements) in this region showed that the dioxin response elements located at -833 is essential for constitutive gene expression in MCF-7 cells.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	16-41
11032419-2	2000	Phosphorylation is known to regulate the transformation process of unliganded AhR into functionally active AhR/ARNT heterodimer that has high affinity for dioxin-responsive elements (DRE) and transactivation activity.	Dioxins	155-161	aryl hydrocarbon receptor	Homo sapiens	78-81
11032419-2	2000	Phosphorylation is known to regulate the transformation process of unliganded AhR into functionally active AhR/ARNT heterodimer that has high affinity for dioxin-responsive elements (DRE) and transactivation activity.	Dioxins	155-161	aryl hydrocarbon receptor	Homo sapiens	107-110
11032419-2	2000	Phosphorylation is known to regulate the transformation process of unliganded AhR into functionally active AhR/ARNT heterodimer that has high affinity for dioxin-responsive elements (DRE) and transactivation activity.	Dioxins	155-161	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	111-115
10986007-1	2000	The Toxic Equivalency Factor (TEF) method is used to estimate potential health risks associated with exposure to dioxin-like chemicals.	Dioxins	113-119	thyrotroph embryonic factor	Mus musculus	4-28
10986007-1	2000	The Toxic Equivalency Factor (TEF) method is used to estimate potential health risks associated with exposure to dioxin-like chemicals.	Dioxins	113-119	thyrotroph embryonic factor	Mus musculus	30-33
10973493-2	2000	Although the aryl hydrocarbon receptor is more commonly studied for its role in regulating xenobiotic metabolism and dioxin toxicity, a developmental role of this protein is supported by the observation that Ah null mice display smaller livers, reduced fecundity, and decreased body weights.	Dioxins	117-123	aryl-hydrocarbon receptor	Mus musculus	13-38
11016874-2	2000	PCB 126 because of its dioxin-like configuration and high toxicity and PCB 153 because it is one of the most commonly detected PCB congeners in breast milk.	Dioxins	23-29	pyruvate carboxylase	Homo sapiens	0-3
11693948-19	2000	Both dioxin-like and non-dioxin-like PCB congeners have been shown to induce neurobehavioral alterations in animals.	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	37-40
10959609-10	2000	Correlation analyses between body burden, PCDD/PCDF TEQ, Co-PCB TEQ and various laboratory data showed significant positive correlations between dioxin levels and GGT, total protein, uric acid and calcium, and a negative correlation with Fe.	Dioxins	145-151	Pyruvate carboxylase	Drosophila melanogaster	60-63
14973392-6	2000	AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery.	Dioxins	192-198	aryl hydrocarbon receptor	Homo sapiens	0-3
14973392-6	2000	AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery.	Dioxins	192-198	cathepsin D	Homo sapiens	38-49
14973392-6	2000	AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery.	Dioxins	192-198	trefoil factor 1	Homo sapiens	51-54
14973392-6	2000	AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery.	Dioxins	192-198	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-61
14973392-6	2000	AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery.	Dioxins	192-198	aryl hydrocarbon receptor	Homo sapiens	140-143
10799651-8	2000	These data demonstrated that iron-chelating and hypoxic agents inhibited dioxin-induced Cyp1a1 transcription in Hepa-I cells.	Dioxins	73-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
10871357-0	2000	An aryl hydrocarbon receptor conformation acts as the functional core of nuclear dioxin signaling.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	3-28
10692565-1	2000	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin), the prototype agonist of the aromatic hydrocarbon (Ah) receptor, is a potent tumor promoter as well as a complete liver carcinogen that produces an oxidative stress response in rodents and in cultured cell lines.	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	81-115
10764452-2	2000	To understand the potential underlying molecular mechanisms we studied the expressions of cytochrome P-450 genes (CYP1A1, CYP1A2, and CYP1B1 ), which are induced by dioxin, and the expressions of cytosolic receptor for dioxin, aryl hydrocarbon receptor, and its nuclear translocator, aryl hydrocarbon receptor nuclear translocator protein, in endometriotic and eutopic endometrial tissues.	Dioxins	165-171	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	114-120
10764452-2	2000	To understand the potential underlying molecular mechanisms we studied the expressions of cytochrome P-450 genes (CYP1A1, CYP1A2, and CYP1B1 ), which are induced by dioxin, and the expressions of cytosolic receptor for dioxin, aryl hydrocarbon receptor, and its nuclear translocator, aryl hydrocarbon receptor nuclear translocator protein, in endometriotic and eutopic endometrial tissues.	Dioxins	165-171	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	122-128
10764452-2	2000	To understand the potential underlying molecular mechanisms we studied the expressions of cytochrome P-450 genes (CYP1A1, CYP1A2, and CYP1B1 ), which are induced by dioxin, and the expressions of cytosolic receptor for dioxin, aryl hydrocarbon receptor, and its nuclear translocator, aryl hydrocarbon receptor nuclear translocator protein, in endometriotic and eutopic endometrial tissues.	Dioxins	165-171	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	134-140
10764452-8	2000	On the other hand, levels of transcripts of another dioxin-induced gene, CYP1A1, were found to be strikingly higher in endometriotic tissues than in the eutopic endometrium.	Dioxins	52-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
10764452-11	2000	CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells.	Dioxins	65-71	aryl hydrocarbon receptor	Homo sapiens	102-127
10764452-11	2000	CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells.	Dioxins	65-71	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	132-178
10764452-11	2000	CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells.	Dioxins	65-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	204-210
10764452-11	2000	CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells.	Dioxins	65-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	212-218
10764452-11	2000	CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells.	Dioxins	65-71	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	224-230
10764452-13	2000	In fact, the proposed link between dioxin exposure and endometriosis may be explained in part by the up-regulation of the CYP1A1 gene expression in endometriotic tissues.	Dioxins	35-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-128
10912239-11	2000	Countries that started to implement measures to reduce dioxin emissions in the late 1980s, such as The Netherlands, United Kingdom and Germany, clearly show decreasing PCDD/PCDF and PCB levels in food and consequently a significantly lower dietary intake of these compounds by almost a factor of 2 within the past 7 years.	Dioxins	55-61	pyruvate carboxylase	Homo sapiens	182-185
10912241-1	2000	The toxicokinetic determinants of dioxin and related chemicals depend on three major properties: lipophilicity, metabolism, and binding to CYP1A2 in the liver.	Dioxins	34-40	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	139-145
10900145-0	2000	Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3, 3",4,4",5-pentachlorobiphenyl.	Dioxins	56-62	carbonic anhydrase 3	Rattus norvegicus	15-37
10913616-0	2000	Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin.	Dioxins	106-112	aryl hydrocarbon receptor	Homo sapiens	69-94
10913616-1	2000	Dioxins invade the body mainly through the diet, and produce toxicity through the transformation of aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	100-125
10913616-1	2000	Dioxins invade the body mainly through the diet, and produce toxicity through the transformation of aryl hydrocarbon receptor (AhR).	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	127-130
11048681-7	2000	Chicken AhR dimerized with human AhR nuclear translocator and bound the mammalian dioxin-response element in a ligand-dependent manner.	Dioxins	82-88	aryl hydrocarbon receptor 1 alpha	Gallus gallus	8-11
11026553-7	2000	This effect may be attributable to AHR interaction with dioxin-responsive elements present in the genes encoding these enzymes.	Dioxins	56-62	aryl hydrocarbon receptor	Rattus norvegicus	35-38
10823667-0	2000	Nitric oxide inhibits dioxin action for the stimulation of Cyp1a1 promoter activity.	Dioxins	22-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
10823667-8	2000	These data demonstrated that nitric oxide might be a mediator of iron chelating agents and hypoxic agents to inhibit dioxin induced Cyp1a1 promoter activity in Hepa I cells.	Dioxins	117-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
10779392-1	2000	The aryl hydrocarbon receptor (AHR) is known to mediate the toxic and carcinogenic effects of polycyclic aromatic hydrocarbons and dioxins.	Dioxins	131-138	aryl-hydrocarbon receptor	Mus musculus	4-29
10779392-1	2000	The aryl hydrocarbon receptor (AHR) is known to mediate the toxic and carcinogenic effects of polycyclic aromatic hydrocarbons and dioxins.	Dioxins	131-138	aryl-hydrocarbon receptor	Mus musculus	31-34
10788565-1	2000	The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biologic and toxicologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	174-180	aryl hydrocarbon receptor	Homo sapiens	4-33
10788565-1	2000	The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biologic and toxicologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	174-180	aryl hydrocarbon receptor	Homo sapiens	35-38
10702233-7	2000	Mutation of the aryl hydrocarbon receptor response elements (dioxin response elements) in this region showed that the dioxin response elements located at -833 is essential for constitutive gene expression in MCF-7 cells.	Dioxins	118-124	aryl hydrocarbon receptor	Homo sapiens	16-41
10702233-10	2000	Furthermore, at least one of the dioxin response elements in the enhancer region is required for constitutive expression of CYP1B1.	Dioxins	33-39	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	124-130
10597900-2	1999	We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity.	Dioxins	147-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	177-183
11216487-3	2000	Thus, suppression of the AhR transformation by food factors can suppress the dioxin toxicity.	Dioxins	77-83	aryl hydrocarbon receptor	Homo sapiens	25-28
11216487-5	2000	The transformed AhR was detected by an electrophoretic mobility shift assay with a DNA oligonucleotide consensus to dioxin response element.	Dioxins	116-122	aryl hydrocarbon receptor	Homo sapiens	16-19
10665428-2	2000	The optimum temperatures for dioxin formation were found at 350 degrees C for boiler ash, 300 degrees C for cyclone ash and 250 degrees C for ESP ash, respectively.	Dioxins	29-35	Epidermal stripes and patches	Drosophila melanogaster	142-145
10630420-6	2000	They diverged in the ability of the AhR-HAC complex to bind to a synthetic oligonucleotide containing the consensus dioxin response enhancer sequence, as studied by the gel retardation assay.	Dioxins	116-122	aryl hydrocarbon receptor	Rattus norvegicus	36-39
10593927-1	1999	The basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor (DR) translocates to the nucleus upon binding of aromatic hydrocarbon ligands typified by dioxin, whereupon it partners the Ah receptor nuclear translocator and initiates transcription.	Dioxins	56-62	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	31-35
10593927-1	1999	The basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor (DR) translocates to the nucleus upon binding of aromatic hydrocarbon ligands typified by dioxin, whereupon it partners the Ah receptor nuclear translocator and initiates transcription.	Dioxins	56-62	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	196-228
10605936-2	2000	This battery represents the Ah receptor (AHR)-mediated control of at least six, and probably many more, dioxin-inducible genes; two cytochrome P450 genes-P450 1A1 and 1A2 (Cypla1, Cypla2-and four non-P450 genes, have experimentally been documented to be members of this battery.	Dioxins	104-110	aryl hydrocarbon receptor	Homo sapiens	28-39
10605936-2	2000	This battery represents the Ah receptor (AHR)-mediated control of at least six, and probably many more, dioxin-inducible genes; two cytochrome P450 genes-P450 1A1 and 1A2 (Cypla1, Cypla2-and four non-P450 genes, have experimentally been documented to be members of this battery.	Dioxins	104-110	aryl hydrocarbon receptor	Homo sapiens	41-44
10605936-4	2000	Oxidative stress activates genes via the electrophile response element (EPRE) DNA motif, whereas dioxin (acutely) activates genes via the AHR-mediated aromatic hydrocarbon response element (AHRE) DNA motif.	Dioxins	97-103	aryl hydrocarbon receptor	Homo sapiens	138-141
10605936-5	2000	In contrast to dioxin, AHR ligands that are readily metabolized to ROMs (e.g. benzo[a]pyrene, beta-naphthoflavone) activate genes via both AHREs and the EPRE.	Dioxins	15-21	aryl hydrocarbon receptor	Homo sapiens	23-26
10667131-6	1999	Dioxins bind to and exert their effects through the cytoplasmic aryl hydrocarbon receptor, which acts as a transcription factor and regulates a number of cytokines and microsomal enzymes.	Dioxins	0-7	aryl hydrocarbon receptor	Homo sapiens	64-89
10667131-9	1999	Dioxins inhibit epidermal growth factor receptor, activate protein kinase C and other intracellular signal transducers, and activate transcription factors.	Dioxins	0-7	epidermal growth factor receptor	Homo sapiens	16-48
10496962-0	1999	Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity.	Dioxins	101-107	aryl hydrocarbon receptor	Homo sapiens	43-68
10544057-1	1999	The arylhydrocarbon receptor (AhR) and the arylhydrocarbon receptor nuclear translocator (ARNT) are members of the PAS gene family mediating toxic effects of xenobiotics such as dioxin and polychlorinated biphenyls.	Dioxins	178-184	aryl hydrocarbon receptor	Oryctolagus cuniculus	30-33
10544057-1	1999	The arylhydrocarbon receptor (AhR) and the arylhydrocarbon receptor nuclear translocator (ARNT) are members of the PAS gene family mediating toxic effects of xenobiotics such as dioxin and polychlorinated biphenyls.	Dioxins	178-184	aryl hydrocarbon receptor nuclear translocator	Oryctolagus cuniculus	43-88
10544057-1	1999	The arylhydrocarbon receptor (AhR) and the arylhydrocarbon receptor nuclear translocator (ARNT) are members of the PAS gene family mediating toxic effects of xenobiotics such as dioxin and polychlorinated biphenyls.	Dioxins	178-184	aryl hydrocarbon receptor nuclear translocator	Oryctolagus cuniculus	90-94
10496962-1	1999	Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	0-25
10496962-1	1999	Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	27-30
10496962-4	1999	Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo.	Dioxins	52-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-105
10496962-4	1999	Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo.	Dioxins	52-58	interleukin 1 beta	Homo sapiens	110-127
10591537-0	1999	Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression.	Dioxins	108-114	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	48-55
10591537-1	1999	The mouse cytosolic aldehyde dehydrogenase ALDH3A1 (encoded by the Aldh3a1 gene) has previously been shown in cell culture to be markedly inducible by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD; dioxin), downregulated by the metabolism of functional CYP1A1/1A2 enzymes, and upregulated by a gene on Chr 7 that leads to endogenous oxidative stress.	Dioxins	181-187	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	43-50
10591537-1	1999	The mouse cytosolic aldehyde dehydrogenase ALDH3A1 (encoded by the Aldh3a1 gene) has previously been shown in cell culture to be markedly inducible by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD; dioxin), downregulated by the metabolism of functional CYP1A1/1A2 enzymes, and upregulated by a gene on Chr 7 that leads to endogenous oxidative stress.	Dioxins	181-187	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	67-74
10591537-5	1999	Deletion fusion constructs containing regions of the Aldh3a1 gene 5" flanking sequence, ligated to chloramphenicol experiments suggested that the 5" flanking region of the gene contains a strong promoter, at least four functional AHREs appear to act cooperatively in causing dioxin-mediated upregulation, and a putative negative regulatory element (NRE) controls basal gene expression independent of dioxin inducibility.	Dioxins	275-281	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	53-60
10591537-5	1999	Deletion fusion constructs containing regions of the Aldh3a1 gene 5" flanking sequence, ligated to chloramphenicol experiments suggested that the 5" flanking region of the gene contains a strong promoter, at least four functional AHREs appear to act cooperatively in causing dioxin-mediated upregulation, and a putative negative regulatory element (NRE) controls basal gene expression independent of dioxin inducibility.	Dioxins	400-406	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	53-60
10591537-6	1999	The dioxin-mediated upregulation of Aldh3a1 expression in mouse hepatoma Hepa-1c1c7 cell cultures was shown to depend exclusively on the aromatic hydrocarbon receptor.	Dioxins	4-10	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	36-43
10591537-9	1999	The dioxin-mediated upregulation of Aldh3a1 expression in mouse hepatoma Hepa-1c1c7 cell cultures was shown to depend exclusively on the aromatic hydrocarbon receptor.	Dioxins	4-10	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	36-43
10433921-3	1999	Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	0-6	spineless	Drosophila melanogaster	61-64
10433921-3	1999	Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	0-6	spineless	Drosophila melanogaster	74-77
10433921-3	1999	Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	0-6	tango	Drosophila melanogaster	163-209
10433921-3	1999	Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	0-6	tango	Drosophila melanogaster	211-215
10465287-1	1999	Hexachlorobenzene (HCB) is a dioxin-type chemical that acts mainly through the aryl hydrocarbon receptor.	Dioxins	29-35	aryl hydrocarbon receptor	Rattus norvegicus	79-104
10458397-13	1999	Germ cell counts and estrogen receptor alpha mRNA expression in gubernaculum and epididymis were significantly reduced, and estrogen receptor a protein expression in testis appeared to be increased by dioxin exposure.	Dioxins	201-207	estrogen receptor 1	Sus scrofa	21-44
10458397-13	1999	Germ cell counts and estrogen receptor alpha mRNA expression in gubernaculum and epididymis were significantly reduced, and estrogen receptor a protein expression in testis appeared to be increased by dioxin exposure.	Dioxins	201-207	estrogen receptor 1	Sus scrofa	21-40
10458397-14	1999	Aberrant regulation of estrogen receptor a expression by dioxin may contribute to reproductive tract anomalies in male fetuses.	Dioxins	57-63	estrogen receptor 1	Sus scrofa	23-42
10478842-5	1999	The E2-responsive sequence (-1220 to -1155) in the c-fos gene promoter contains two putative core pentanucleotide dioxin-responsive elements (DREs) at -1206 to -1202 and -1163 to -1159.	Dioxins	114-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-56
10366545-1	1999	The arylhydrocarbon receptor (AhR) is a ligand-activated transcription factor and mediates carcinogenic, teratogenic, and toxic effects of xenobiotics such as dioxin and coplanar polychlorinated biphenyls.	Dioxins	159-165	aryl hydrocarbon receptor	Oryctolagus cuniculus	4-28
10471301-1	1999	The region of residues -145 to -119 (CD/L) of the cathepsin D gene promoter contains a GC-rich motif that binds Sp1 protein and an adjacent pentanucleotide (CACGC) that corresponds to the core sequence of a dioxin responsive element (DRE) and binds the aryl hydrocarbon receptor (AhR)-AhR nuclear translocator (Arnt) complex.	Dioxins	207-213	cathepsin D	Homo sapiens	50-61
10428779-4	1999	The sequence of events following the binding of the AhR/AhR nuclear translocator protein (ARNT) heterodimer to dioxin response elements has yet to be completely understood.	Dioxins	111-117	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	52-88
10428779-4	1999	The sequence of events following the binding of the AhR/AhR nuclear translocator protein (ARNT) heterodimer to dioxin response elements has yet to be completely understood.	Dioxins	111-117	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	90-94
10428779-6	1999	RIP140 enhanced TCDD-mediated, dioxin response element-driven reporter gene activity in three cell lines.	Dioxins	31-37	nuclear receptor interacting protein 1	Homo sapiens	0-6
10409767-2	1999	Upon binding of polycyclic aromatic hydrocarbons typified by dioxin, the dioxin receptor translocates from the cytoplasm to the nucleus to allow interaction with Arnt.	Dioxins	61-67	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	162-166
10409767-4	1999	Treatment of the nuclear receptor with dioxin induces dimerization with Arnt to form an active transcription factor complex, while in stark contrast, treatment with the hsp90 ligand geldanamycin results in rapid degradation of the receptor.	Dioxins	39-45	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	72-76
10409767-8	1999	Limited proteolysis of DR-Arnt heterodimers indicated different conformations for dioxin versus geldanamycin-transformed receptors.	Dioxins	82-88	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	23-30
10395741-3	1999	The AhR, AhR nuclear translocator (Arnt), and AhR/Arnt proteins were coimmunoprecipitated with 35S-ERAP 140 and 35S-SMRT and, in gel mobility shift assays, AhR/Arnt binding to 32P-dioxin response element (DRE) was enhanced by ERAP-140 and inhibited by SMRT; supershifted bands were not observed.	Dioxins	180-186	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	50-54
10395741-3	1999	The AhR, AhR nuclear translocator (Arnt), and AhR/Arnt proteins were coimmunoprecipitated with 35S-ERAP 140 and 35S-SMRT and, in gel mobility shift assays, AhR/Arnt binding to 32P-dioxin response element (DRE) was enhanced by ERAP-140 and inhibited by SMRT; supershifted bands were not observed.	Dioxins	180-186	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	50-54
10398686-1	1999	The Ah receptor (AhR), a bHLH/PAS transcription factor, mediates dioxin toxicity in the immune system, skin, testis and liver.	Dioxins	65-71	aryl-hydrocarbon receptor	Mus musculus	4-15
10398686-1	1999	The Ah receptor (AhR), a bHLH/PAS transcription factor, mediates dioxin toxicity in the immune system, skin, testis and liver.	Dioxins	65-71	aryl-hydrocarbon receptor	Mus musculus	17-20
10398686-5	1999	Kip1 causes dioxin-induced suppression of 5L hepatoma cell proliferation because Kip1 antisense-expressing cells are resistant to dioxins.	Dioxins	12-18	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-4
10398686-5	1999	Kip1 causes dioxin-induced suppression of 5L hepatoma cell proliferation because Kip1 antisense-expressing cells are resistant to dioxins.	Dioxins	12-18	cyclin-dependent kinase inhibitor 1B	Mus musculus	81-85
10398686-5	1999	Kip1 causes dioxin-induced suppression of 5L hepatoma cell proliferation because Kip1 antisense-expressing cells are resistant to dioxins.	Dioxins	130-137	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-4
10398686-6	1999	Kip1 is also induced by dioxins in cultures of fetal thymus glands concomitant with inhibition of proliferation and severe reduction of thymocyte recovery.	Dioxins	24-31	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-4
10366545-1	1999	The arylhydrocarbon receptor (AhR) is a ligand-activated transcription factor and mediates carcinogenic, teratogenic, and toxic effects of xenobiotics such as dioxin and coplanar polychlorinated biphenyls.	Dioxins	159-165	aryl hydrocarbon receptor	Oryctolagus cuniculus	30-33
10224119-5	1999	Here we demonstrate that Arnt is associated with a fibroblast-specific factor, forming a complex that is capable of binding the dioxin response element.	Dioxins	128-134	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	25-29
10224119-7	1999	Finally, the negative regulatory function of this factor appears to be restricted for dioxin signaling since Arnt was able to mediate, together with hypoxia-inducible factor-1alpha, transcriptional activation in hypoxic cells.	Dioxins	86-92	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	109-113
10224119-7	1999	Finally, the negative regulatory function of this factor appears to be restricted for dioxin signaling since Arnt was able to mediate, together with hypoxia-inducible factor-1alpha, transcriptional activation in hypoxic cells.	Dioxins	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-180
10224119-8	1999	Taken together, these data suggest that fibroblast-specific inhibition of dioxin responsiveness involves recruitment by Arnt of a cell type- and signaling pathway-specific corepressor associated with a histone deacetylase.	Dioxins	74-80	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	120-124
10323376-5	1999	Among nondiabetic veterans, we found the mean of the logarithm of insulin significantly increased in the high dioxin category.	Dioxins	110-116	insulin	Homo sapiens	66-73
10323376-6	1999	Additionally, in nondiabetic veterans the relation between SHBG and insulin interacted significantly with dioxin category on the log scale within strata defined by age and percent body fat.	Dioxins	106-112	sex hormone binding globulin	Homo sapiens	59-63
10323376-6	1999	Additionally, in nondiabetic veterans the relation between SHBG and insulin interacted significantly with dioxin category on the log scale within strata defined by age and percent body fat.	Dioxins	106-112	insulin	Homo sapiens	68-75
10323376-8	1999	These findings suggest a compensatory metabolic relationship between dioxin and insulin regulation.	Dioxins	69-75	insulin	Homo sapiens	80-87
10340472-0	1999	Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression.	Dioxins	85-91	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-41
10340472-2	1999	Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively.	Dioxins	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-56
10340472-2	1999	Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively.	Dioxins	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
10340472-2	1999	Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively.	Dioxins	131-137	aryl hydrocarbon receptor	Homo sapiens	74-103
10340472-2	1999	Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively.	Dioxins	131-137	aryl hydrocarbon receptor	Homo sapiens	105-108
10340472-9	1999	Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR"s function on the dioxin-responsive reporter gene and the endogenous gene.	Dioxins	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
10340472-9	1999	Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR"s function on the dioxin-responsive reporter gene and the endogenous gene.	Dioxins	98-104	aryl hydrocarbon receptor	Homo sapiens	113-116
10340472-9	1999	Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR"s function on the dioxin-responsive reporter gene and the endogenous gene.	Dioxins	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
10340472-9	1999	Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR"s function on the dioxin-responsive reporter gene and the endogenous gene.	Dioxins	135-141	aryl hydrocarbon receptor	Homo sapiens	113-116
10378784-5	1999	Electrophoretic mobility shift assay using nuclear extraction of cells revealed that alpha-Hederin reduced transformation of the Ah receptor to a form capable of specifically binding to an oligonucleotide containing a dioxin-response element (DRE) sequence of the Cyp1a-1 gene.	Dioxins	218-224	aryl-hydrocarbon receptor	Mus musculus	129-140
10207038-4	1999	ARNT complex binds to "dioxin responsive enhancers" (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1a1).	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
10207038-4	1999	ARNT complex binds to "dioxin responsive enhancers" (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1a1).	Dioxins	23-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-145
10207038-4	1999	ARNT complex binds to "dioxin responsive enhancers" (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1a1).	Dioxins	23-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	147-153
10207038-10	1999	These experiments outline conditions where inhibitory and additive cross-talk occur between the hypoxia and dioxin signal transduction pathways and identify Epo as an AHR-regulated gene.	Dioxins	108-114	erythropoietin	Homo sapiens	157-160
10378784-5	1999	Electrophoretic mobility shift assay using nuclear extraction of cells revealed that alpha-Hederin reduced transformation of the Ah receptor to a form capable of specifically binding to an oligonucleotide containing a dioxin-response element (DRE) sequence of the Cyp1a-1 gene.	Dioxins	218-224	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	264-271
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	61-67	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
10376761-1	1999	We studied the phenotype and the nucleotide sequence for the cDNAs of the Aldh3a1a and Aldh3a1c allelic forms of the dioxin-inducible cytosolic aldehyde dehydrogenase (ALDH3A1) present in inbred mouse strains.	Dioxins	117-123	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	168-175
10092435-5	1999	PCB 77 was the major "dioxin-like" congener in the fish, followed by PCB 126 and then PCB 169.	Dioxins	22-28	pyruvate carboxylase	Homo sapiens	0-3
10947077-3	1999	Although many details of the overall dioxin signal transduction have been elucidated, the transcriptional regulation of dioxin-induced genes like cyp1A1 is not yet completely understood.	Dioxins	120-126	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	146-152
10022276-5	1998	The results indicate that the nuclear AhR complex targets specific genomic core inhibitory dioxin responsive elements (iDREs) in promoter regions of some E2-responsive target genes to inhibit hormone-induced transactivation.	Dioxins	91-97	aryl hydrocarbon receptor	Homo sapiens	38-41
9864300-8	1998	Moreover, because the increase in the relative magnitude of CYP1A1 protein in response to LPS occurred in the absence of exogenous AhR ligand, these results suggest that B-cell activation is sufficient to induce AhR nuclear translocation and binding to dioxin-responsive elements in the promoter region of AhR-responsive genes.	Dioxins	253-259	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	60-66
9881947-0	1998	Epidermal growth factor receptor as a mediator of developmental toxicity of dioxin in mouse embryonic teeth.	Dioxins	76-82	epidermal growth factor receptor	Mus musculus	0-32
9881947-11	1998	Thus, EGFR may also play a role in the developmental defects that dioxins cause in human teeth.	Dioxins	66-73	epidermal growth factor receptor	Homo sapiens	6-10
10036221-7	1999	AHR from hepatic cytosol of both the L-E and H/W rats could be transformed to the DNA-binding state in the presence of TCDD or other dioxin congeners as assessed by gel mobility shift assays.	Dioxins	133-139	aryl hydrocarbon receptor	Rattus norvegicus	0-3
9920887-8	1999	Transfecting ECC-1 cells with a general transcription factor involved in CYP1A1 induction, nuclear factor-1, reversed 17beta-estradiol antagonism of dioxin induced-CYP1A1.	Dioxins	149-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
9920887-8	1999	Transfecting ECC-1 cells with a general transcription factor involved in CYP1A1 induction, nuclear factor-1, reversed 17beta-estradiol antagonism of dioxin induced-CYP1A1.	Dioxins	149-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	164-170
10067811-2	1999	Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen.	Dioxins	34-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19
10067811-2	1999	Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen.	Dioxins	34-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27
10067811-3	1999	Therefore, the analysis of CYP1B1 in humans may be useful in establishing relationships between dioxin exposure and adverse health effects.	Dioxins	96-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33
10067811-10	1999	These data define the suitability of CYP1B1 for use as a mechanistically based biomarker in ongoing molecular epidemiological studies of human populations exposed to dioxins and related chemicals that bind the aromatic hydrocarbon receptor.	Dioxins	166-173	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43
10903109-5	1999	New data on the dioxin-like PCB emissions are presented for cement kilns and sinter plants.	Dioxins	16-22	pyruvate carboxylase	Homo sapiens	28-31
10190573-2	1999	Induction of cytochrome P4501A1 (CYP1A1) in mammalian cell culture is widely used as a functional parameter for AHR activation providing an estimate for "dioxin-like" inducing equivalents in extracts from environmental samples.	Dioxins	154-160	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-31
10190573-2	1999	Induction of cytochrome P4501A1 (CYP1A1) in mammalian cell culture is widely used as a functional parameter for AHR activation providing an estimate for "dioxin-like" inducing equivalents in extracts from environmental samples.	Dioxins	154-160	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
10190573-2	1999	Induction of cytochrome P4501A1 (CYP1A1) in mammalian cell culture is widely used as a functional parameter for AHR activation providing an estimate for "dioxin-like" inducing equivalents in extracts from environmental samples.	Dioxins	154-160	aryl hydrocarbon receptor	Homo sapiens	112-115
9931422-9	1999	In vitro produced zfAhR2 protein dimerizes with the rainbow trout aryl hydrocarbon receptor nuclear translocator (rtARNTb) and binds dioxin response elements derived from the rainbow trout CYP1A gene.	Dioxins	133-139	aryl hydrocarbon receptor 2	Danio rerio	18-24
10352679-0	1999	Prepubertal regulation of the rat dioxin-inducible aldehyde dehydrogenase (ALDH3).	Dioxins	34-40	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	75-80
10331078-6	1999	Mechanistic analyses of cytochrome P4501A1 induction provide insights into ligand-dependent mammalian gene expression, basic helix-loop-helix/Per-Arnt-Sim protein function, and dioxin action; such studies also impact public health issues concerned with molecular epidemiology, carcinogenesis, and risk assessment.	Dioxins	177-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-42
9872716-13	1999	Breast-feeding for 6 months contributed to the cumulative PCB/dioxin TEQ intake until 25 years of age, 12% in boys and 14% in girls.	Dioxins	62-68	pyruvate carboxylase	Homo sapiens	58-61
9867872-0	1999	Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	0-11
9867872-0	1999	Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity.	Dioxins	66-72	nuclear factor kappa B subunit 1	Homo sapiens	16-25
10503953-9	1999	However, B[a]P induced a retarded band with the [32P]-dioxin responsive element in CL3 cells, but not in A427 cells.	Dioxins	54-60	adhesion G protein-coupled receptor L3	Homo sapiens	83-86
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	113-124
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	61-67	aryl hydrocarbon receptor	Homo sapiens	126-129
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	61-67	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	196-220
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	61-67	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	222-226
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	99-105	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	113-124
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	99-105	aryl hydrocarbon receptor	Homo sapiens	126-129
10373624-1	1999	: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences.	Dioxins	99-105	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	222-226
10373624-7	1999	All of our trout CYP1A3 promoter data are consistent with dioxin-inducible luciferase activity being controlled by two or more AHREs via cooperativity with a GC-rich region (-1852)-as has previously been demonstrated for AHREs in mammalian CYP1A1 promoters.	Dioxins	58-64	cytochrome P450 1A3	Oncorhynchus mykiss	17-23
10373624-7	1999	All of our trout CYP1A3 promoter data are consistent with dioxin-inducible luciferase activity being controlled by two or more AHREs via cooperativity with a GC-rich region (-1852)-as has previously been demonstrated for AHREs in mammalian CYP1A1 promoters.	Dioxins	58-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	240-246
10072167-4	1998	Electrophoretic mobility shift assay using nuclear extract of cells revealed that estradiol reduced transformation of the Ah receptor to the form capable of specifically binding to an oligonucleotide containing dioxin-response element (DRE) sequence.	Dioxins	211-217	aryl-hydrocarbon receptor	Mus musculus	122-133
9802319-11	1998	Of particular interest is the remarkably strong expression of the recently identified dioxin inducible CYP1B1, known to be present in a wide range of malignant tumors.	Dioxins	86-92	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-109
9972449-2	1998	Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR.	Dioxins	90-97	aryl hydrocarbon receptor	Homo sapiens	16-19
9972449-2	1998	Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR.	Dioxins	90-97	aryl hydrocarbon receptor	Homo sapiens	192-195
9799183-6	1998	For the estimation of the total dioxin activity in an environmental biological sample, the TEF value of a compound is multiplied by the concentration in the specific matrix.	Dioxins	32-38	TEF transcription factor, PAR bZIP family member	Homo sapiens	91-94
10366995-5	1998	Furthermore, the response obtained with a mixture of dioxins was additive, in accordance with the TEF-principle.	Dioxins	53-60	TEF transcription factor, PAR bZIP family member	Bos taurus	98-101
10366995-12	1998	Testing of 22 bovine milk samples, taken at different sites in The Netherlands, in the CALUX-assay showed combined dioxin and dioxin-like PCB levels equivalent to 1.6 pg TCDD/g fat (range 0.2-4.6).	Dioxins	126-132	pyruvate carboxylase	Bos taurus	138-141
9828293-4	1998	New experimental data has revealed that a variety of structural, functional and behaviourial alterations can be induced in rodent species following exposure to PHAHs while a Dutch collaborative PCB/dioxin study has illustrated subtle clinical, endocrine and mental/psychomotor development effects can occur in breast fed infants.	Dioxins	198-204	pyruvate carboxylase	Homo sapiens	194-197
9447995-10	1998	XAP2 enhanced the ability of endogenous murine and human AhR complexes to activate a dioxin-responsive element-luciferase reporter twofold, following transient expression of XAP2 in Hepa 1c1c7 and HeLa cells.	Dioxins	85-91	aryl-hydrocarbon receptor-interacting protein	Mus musculus	0-4
9874250-1	1998	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) induces gene transcription, a process that requires binding of the activated aryl hydrocarbon receptor (AhR) to dioxin-responsive elements (DREs) within the enhancer region of responsive genes.	Dioxins	59-65	aryl hydrocarbon receptor	Homo sapiens	160-185
9874250-1	1998	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) induces gene transcription, a process that requires binding of the activated aryl hydrocarbon receptor (AhR) to dioxin-responsive elements (DREs) within the enhancer region of responsive genes.	Dioxins	59-65	aryl hydrocarbon receptor	Homo sapiens	187-190
9874250-1	1998	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) induces gene transcription, a process that requires binding of the activated aryl hydrocarbon receptor (AhR) to dioxin-responsive elements (DREs) within the enhancer region of responsive genes.	Dioxins	75-81	aryl hydrocarbon receptor	Homo sapiens	160-185
9874250-1	1998	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) induces gene transcription, a process that requires binding of the activated aryl hydrocarbon receptor (AhR) to dioxin-responsive elements (DREs) within the enhancer region of responsive genes.	Dioxins	75-81	aryl hydrocarbon receptor	Homo sapiens	187-190
9783725-3	1998	The UGT1A6 gene (formerly known as UGT1*06 and UGT1A1) has been suggested to belong to the aryl hydrocarbon (Ah) gene battery, which consists of several genes encoding for drug-metabolising enzymes regulated by dioxin and other ligands of the Ah receptor.	Dioxins	211-217	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	4-10
9783725-3	1998	The UGT1A6 gene (formerly known as UGT1*06 and UGT1A1) has been suggested to belong to the aryl hydrocarbon (Ah) gene battery, which consists of several genes encoding for drug-metabolising enzymes regulated by dioxin and other ligands of the Ah receptor.	Dioxins	211-217	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	35-42
9783725-3	1998	The UGT1A6 gene (formerly known as UGT1*06 and UGT1A1) has been suggested to belong to the aryl hydrocarbon (Ah) gene battery, which consists of several genes encoding for drug-metabolising enzymes regulated by dioxin and other ligands of the Ah receptor.	Dioxins	211-217	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	47-53
9783725-3	1998	The UGT1A6 gene (formerly known as UGT1*06 and UGT1A1) has been suggested to belong to the aryl hydrocarbon (Ah) gene battery, which consists of several genes encoding for drug-metabolising enzymes regulated by dioxin and other ligands of the Ah receptor.	Dioxins	211-217	aryl hydrocarbon receptor	Rattus norvegicus	243-254
9708986-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	273-279	aryl hydrocarbon receptor	Homo sapiens	4-29
9708986-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	273-279	aryl hydrocarbon receptor	Homo sapiens	31-34
9744540-0	1998	Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor.	Dioxins	124-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	14-20
9687573-1	1998	The aryl hydrocarbon receptor (AHR) is believed to mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such as dioxins, polycyclic aromatic hydrocarbons, and polyhalogenated biphenyls.	Dioxins	154-161	aryl-hydrocarbon receptor	Mus musculus	4-29
9687573-1	1998	The aryl hydrocarbon receptor (AHR) is believed to mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such as dioxins, polycyclic aromatic hydrocarbons, and polyhalogenated biphenyls.	Dioxins	154-161	aryl-hydrocarbon receptor	Mus musculus	31-34
9745906-1	1998	Like dioxin, some polychlorinated biphenyl (PCB) congeners produce toxicity by binding to an aryl hydrocarbon (Ah) receptor.	Dioxins	5-11	aryl hydrocarbon receptor	Homo sapiens	93-123
9707505-12	1998	(1) A structure-activity relationship study with TCDD and three dioxin congeners revealed a rank order for their potency in activation of AhR-associated c-Src kinase from cervical cells which was identical to that of previously determined toxicity indices.	Dioxins	64-70	aryl hydrocarbon receptor	Homo sapiens	138-141
9707505-12	1998	(1) A structure-activity relationship study with TCDD and three dioxin congeners revealed a rank order for their potency in activation of AhR-associated c-Src kinase from cervical cells which was identical to that of previously determined toxicity indices.	Dioxins	64-70	C-terminal Src kinase	Homo sapiens	153-165
9617381-0	1998	Quantitation of the extracellular domain of epidermal growth factor receptor in the plasma of dioxin-exposed individuals.	Dioxins	94-100	epidermal growth factor receptor	Homo sapiens	44-76
9617381-1	1998	Animal models suggest that dioxins have a negative effect on the level of expression of the epidermal growth factor receptor in cells.	Dioxins	27-34	epidermal growth factor receptor	Homo sapiens	92-124
9617381-3	1998	We have determined the levels of the extracellular domain of the epidermal growth factor receptor in the plasma of 30 individuals: 10 with high blood dioxin levels (TEQ range = 318-673 ppt), 10 with medium blood dioxin levels (TEQ range = 16-60 ppt), and 10 with low background blood dioxin levels (TEQ range = 3-10 ppt).	Dioxins	150-156	epidermal growth factor receptor	Homo sapiens	65-97
9617381-3	1998	We have determined the levels of the extracellular domain of the epidermal growth factor receptor in the plasma of 30 individuals: 10 with high blood dioxin levels (TEQ range = 318-673 ppt), 10 with medium blood dioxin levels (TEQ range = 16-60 ppt), and 10 with low background blood dioxin levels (TEQ range = 3-10 ppt).	Dioxins	212-218	epidermal growth factor receptor	Homo sapiens	65-97
9617381-3	1998	We have determined the levels of the extracellular domain of the epidermal growth factor receptor in the plasma of 30 individuals: 10 with high blood dioxin levels (TEQ range = 318-673 ppt), 10 with medium blood dioxin levels (TEQ range = 16-60 ppt), and 10 with low background blood dioxin levels (TEQ range = 3-10 ppt).	Dioxins	212-218	epidermal growth factor receptor	Homo sapiens	65-97
9617381-4	1998	The levels of the epidermal growth factor receptor extracellular domain were lower in the high blood dioxin group (mean +/- SD = 45 +/- 26 fmol/ml) and the medium blood dioxin group (mean +/- SD = 41 +/- 23 fmol/ml) compared with the low blood dioxin group (mean +/- SD = 73 +/- 43 fmol/ml).	Dioxins	101-107	epidermal growth factor receptor	Homo sapiens	18-50
9617381-4	1998	The levels of the epidermal growth factor receptor extracellular domain were lower in the high blood dioxin group (mean +/- SD = 45 +/- 26 fmol/ml) and the medium blood dioxin group (mean +/- SD = 41 +/- 23 fmol/ml) compared with the low blood dioxin group (mean +/- SD = 73 +/- 43 fmol/ml).	Dioxins	169-175	epidermal growth factor receptor	Homo sapiens	18-50
9617381-4	1998	The levels of the epidermal growth factor receptor extracellular domain were lower in the high blood dioxin group (mean +/- SD = 45 +/- 26 fmol/ml) and the medium blood dioxin group (mean +/- SD = 41 +/- 23 fmol/ml) compared with the low blood dioxin group (mean +/- SD = 73 +/- 43 fmol/ml).	Dioxins	169-175	epidermal growth factor receptor	Homo sapiens	18-50
9617381-5	1998	These results suggest that the extracellular domain of the epidermal growth factor receptor may be a marker of the biological effect of dioxin exposure.	Dioxins	136-142	epidermal growth factor receptor	Homo sapiens	59-91
10048125-2	1998	Many of these chemicals are dioxin-like and their relative toxicity is related to their ability to bind and activate the Ah receptor.	Dioxins	28-34	aryl-hydrocarbon receptor	Mus musculus	121-132
9853009-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	272-278	aryl hydrocarbon receptor	Cavia porcellus	4-29
9853009-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	272-278	aryl hydrocarbon receptor	Cavia porcellus	31-34
9853009-8	1998	Not only was dioxin responsive element-driven luciferase gene expression induced by carbaryl in stably transfected mouse, rat, guinea pig, and human cells, gel retardation analysis revealed that carbaryl stimulated AhR transformation and DNA binding in vitro and in cells in culture.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	215-218
9721195-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	174-180	aryl hydrocarbon receptor	Rattus norvegicus	4-29
9721195-1	1998	The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	174-180	aryl hydrocarbon receptor	Rattus norvegicus	31-34
9705885-0	1998	Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice.	Dioxins	127-133	aryl-hydrocarbon receptor	Mus musculus	0-25
9705885-12	1998	These data indicate the ability of TCDD to initiate a signal transduction process leading to a transcriptionally active AhR in these tissues, thereby identifying potential targets of dioxin-induced toxicity during development.	Dioxins	183-189	aryl-hydrocarbon receptor	Mus musculus	120-123
9705900-0	1998	Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo.	Dioxins	58-64	cytochrome P450 1A2	Gallus gallus	75-81
9705900-1	1998	The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively.	Dioxins	27-33	cytochrome P450 1A4	Gallus gallus	73-79
9705900-1	1998	The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively.	Dioxins	27-33	cytochrome P450 1A2	Gallus gallus	84-90
9705900-1	1998	The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively.	Dioxins	144-150	cytochrome P450 1A4	Gallus gallus	73-79
9705900-1	1998	The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two dioxin-inducible forms of P450 previously designated as TCDDAHH and TCDDAA, respectively.	Dioxins	144-150	cytochrome P450 1A2	Gallus gallus	84-90
9705900-3	1998	The purpose of this study was to examine the developmental regulation of the second dioxin-inducible P450 gene, CYP1A5, in chick embryo liver.	Dioxins	84-90	cytochrome P450 1A2	Gallus gallus	112-118
9578599-1	1998	The Ah receptor (AhR) is a soluble ligand-dependent DNA regulatory protein that mediates many of the biological responses to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	155-161	aryl hydrocarbon receptor	Rattus norvegicus	4-15
9578599-1	1998	The Ah receptor (AhR) is a soluble ligand-dependent DNA regulatory protein that mediates many of the biological responses to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals.	Dioxins	155-161	aryl hydrocarbon receptor	Rattus norvegicus	17-20
21781868-2	1998	The aim of this study was to investigate whether a toxic dose of the dioxin-like coplanar PCB modifies enzyme activities in peroxisomes where plays an important role in lipid metabolism.	Dioxins	69-75	pyruvate carboxylase	Rattus norvegicus	90-93
9535862-4	1998	This interference was not only demonstrated by induction of a transfected dioxin-responsive reporter plasmid but also on the AhR-mediated up-regulation of the endogenous cytochrome P450-1A1 activity.	Dioxins	74-80	aryl hydrocarbon receptor	Homo sapiens	125-128
9535862-4	1998	This interference was not only demonstrated by induction of a transfected dioxin-responsive reporter plasmid but also on the AhR-mediated up-regulation of the endogenous cytochrome P450-1A1 activity.	Dioxins	74-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	170-189
9571985-6	1998	At lower dioxin concentrations, our results demonstrated an actual increase in CD8+ cells, whereas DES-treated fetal thymocytes were mainly enriched in CD4-CD8- double-negative cells.	Dioxins	9-15	CD8a molecule	Homo sapiens	79-82
9447995-10	1998	XAP2 enhanced the ability of endogenous murine and human AhR complexes to activate a dioxin-responsive element-luciferase reporter twofold, following transient expression of XAP2 in Hepa 1c1c7 and HeLa cells.	Dioxins	85-91	aryl hydrocarbon receptor	Homo sapiens	57-60
9464894-2	1998	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is the most toxic member of this class of halogenated aromatic hydrocarbons (HAH); mechanistic studies indicate that the toxic and biochemical effects associated with exposure to TCDD are mediated via initial binding to the cytosolic aryl hydrocarbon (Ah) receptor protein present in target tissues and organs.	Dioxins	29-35	aryl hydrocarbon receptor	Homo sapiens	285-315
9464894-5	1998	Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]).	Dioxins	160-166	TEF transcription factor, PAR bZIP family member	Homo sapiens	36-39
9464894-5	1998	Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]).	Dioxins	160-166	TEF transcription factor, PAR bZIP family member	Homo sapiens	143-146
9464896-1	1998	The major dioxin-related research activities in the United States Department of Agriculture are 1) a survey of dioxin levels in beef samples collected at 13 experiment stations throughout the United States, 2) a feeding study of eight dioxins, four furans, and three PCB at levels equal to or above levels expected at highly industrialized locations, and 3) metabolism studies of 14C-labeled dioxin congeners.	Dioxins	10-16	pyruvate carboxylase	Homo sapiens	267-270
9414485-5	1998	Results of experiments with Ah-receptor blockers and structure activity studies with different polychlorinated biphenyl (PCB) and dioxin congeners were consistent with reduction of LPL activity being mediated by the Ah receptor.	Dioxins	130-136	lipoprotein lipase	Mus musculus	181-184
9414485-5	1998	Results of experiments with Ah-receptor blockers and structure activity studies with different polychlorinated biphenyl (PCB) and dioxin congeners were consistent with reduction of LPL activity being mediated by the Ah receptor.	Dioxins	130-136	aryl-hydrocarbon receptor	Mus musculus	216-227
9418899-1	1998	The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery.	Dioxins	227-233	aryl-hydrocarbon receptor	Mus musculus	21-50
9418899-1	1998	The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery.	Dioxins	227-233	aryl-hydrocarbon receptor	Mus musculus	52-55
9418899-1	1998	The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery.	Dioxins	227-233	aryl hydrocarbon receptor nuclear translocator	Mus musculus	76-100
9418899-1	1998	The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery.	Dioxins	227-233	aryl hydrocarbon receptor nuclear translocator	Mus musculus	102-106
10224888-10	1998	These study strongly support the role of AhR in dioxin toxicity.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	41-44
9465260-10	1998	Increased expression of cytochrome P450 1A is a major biochemical consequence of TCDD exposure and is often used as a biomarker for exposure to dioxin-like compounds.	Dioxins	144-150	cytochrome P450 1A1	Oryzias latipes	24-42
9393671-0	1997	Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin.	Dioxins	132-138	prostaglandin-endoperoxide synthase 2	Mus musculus	67-83
9391097-9	1997	Overall, our analyses indicate that the AHR is a phylogenetically ancient protein present in all living vertebrate groups (with a possible invertebrate homolog), thus providing an evolutionary perspective to the study of dioxin toxicity and AHR function.	Dioxins	221-227	aryl hydrocarbon receptor	Homo sapiens	40-43
9415701-6	1997	Activated leukocytes exhibited an even greater enhancement of dioxin response element binding by the AhR in the presence of TCDD than in the absence of TCDD.	Dioxins	62-68	aryl hydrocarbon receptor	Homo sapiens	101-104
9374512-9	1997	A retarded band associated with formation of a [32P]dioxin-responsive element-AhR complex was observed in nuclear extracts from cells treated with TCDD or TCDD plus E2 (cotreated).	Dioxins	52-58	aryl-hydrocarbon receptor	Mus musculus	78-81
9240455-0	1997	Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	8-14
9380021-12	1997	Gel retardation assays demonstrated that bilirubin, but not hemin or biliverdin, was able to transform the AHR to a form capable of specifically binding to a 32P-labeled oligonucleotide containing a dioxin-response element sequence.	Dioxins	199-205	aryl-hydrocarbon receptor	Mus musculus	107-110
9328177-1	1997	Cytochrome P4501B1 (CYP1B1) is the most recently identified member of the dioxin-inducible CYP1 family.	Dioxins	74-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-18
9328177-1	1997	Cytochrome P4501B1 (CYP1B1) is the most recently identified member of the dioxin-inducible CYP1 family.	Dioxins	74-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	20-26
21781786-8	1997	In summary, the non dioxin-like PCB 153 can decrease gap junctional intercellular communication rapidly by reducing the phosphorylated isoform of Cx43, whereas the dioxin-like PCB 126 and TCDD reduce the communication slowly by decreasing the mRNA level of Cx43, resulting in a reduced Cx43 protein level (which includes the P(2)-band).	Dioxins	20-26	pyruvate carboxylase	Rattus norvegicus	32-35
21781786-8	1997	In summary, the non dioxin-like PCB 153 can decrease gap junctional intercellular communication rapidly by reducing the phosphorylated isoform of Cx43, whereas the dioxin-like PCB 126 and TCDD reduce the communication slowly by decreasing the mRNA level of Cx43, resulting in a reduced Cx43 protein level (which includes the P(2)-band).	Dioxins	20-26	gap junction protein, alpha 1	Rattus norvegicus	146-150
21781786-8	1997	In summary, the non dioxin-like PCB 153 can decrease gap junctional intercellular communication rapidly by reducing the phosphorylated isoform of Cx43, whereas the dioxin-like PCB 126 and TCDD reduce the communication slowly by decreasing the mRNA level of Cx43, resulting in a reduced Cx43 protein level (which includes the P(2)-band).	Dioxins	164-170	pyruvate carboxylase	Rattus norvegicus	32-35
21781786-8	1997	In summary, the non dioxin-like PCB 153 can decrease gap junctional intercellular communication rapidly by reducing the phosphorylated isoform of Cx43, whereas the dioxin-like PCB 126 and TCDD reduce the communication slowly by decreasing the mRNA level of Cx43, resulting in a reduced Cx43 protein level (which includes the P(2)-band).	Dioxins	164-170	pyruvate carboxylase	Rattus norvegicus	176-179
21781786-9	1997	The mixed inducing PCB-congener, PCB 118, can act both as the dioxin-like and the non dioxin-like PCBs in gap junction regulation.	Dioxins	62-68	pyruvate carboxylase	Rattus norvegicus	19-22
21781786-9	1997	The mixed inducing PCB-congener, PCB 118, can act both as the dioxin-like and the non dioxin-like PCBs in gap junction regulation.	Dioxins	62-68	pyruvate carboxylase	Rattus norvegicus	33-36
21781786-9	1997	The mixed inducing PCB-congener, PCB 118, can act both as the dioxin-like and the non dioxin-like PCBs in gap junction regulation.	Dioxins	86-92	pyruvate carboxylase	Rattus norvegicus	19-22
21781786-9	1997	The mixed inducing PCB-congener, PCB 118, can act both as the dioxin-like and the non dioxin-like PCBs in gap junction regulation.	Dioxins	86-92	pyruvate carboxylase	Rattus norvegicus	33-36
9299183-11	1997	Similarly, the toxicological effects of dioxins are mediated via the Ah receptor (AHR), another ligand-activated nuclear receptor.	Dioxins	40-47	aryl hydrocarbon receptor	Homo sapiens	69-80
9299183-11	1997	Similarly, the toxicological effects of dioxins are mediated via the Ah receptor (AHR), another ligand-activated nuclear receptor.	Dioxins	40-47	aryl hydrocarbon receptor	Homo sapiens	82-85
9464455-0	1997	Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	15-21
9464455-0	1997	Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	65-71
9464455-0	1997	Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.	Dioxins	43-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	91-97
9464455-4	1997	The differential inducibility of liver CYP1A1 mRNA by dioxin was therefore compared in Cyp1a2(+/+) wild-type mice, Cyp1a2(+/-) heterozygotes, and Cyp1a2(-/-) homozygous null mutants.	Dioxins	54-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	39-45
9230218-1	1997	Cytochrome P450 CYP1B1 is a recently cloned dioxin-inducible form of the cytochrome P450 family of xenobiotic metabolizing enzymes.	Dioxins	44-50	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-22
9199285-0	1997	Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.	Dioxins	62-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	79-85
21781780-6	1997	Since ARNT is a heterodimerization partner of the AhR required for binding of the ligand-activated AhR to dioxin-responsive elements on DNA in the nucleus to transactivate genes controlled by the AhR, an alternative mechanism for TCDD"s action is discussed which does not require ARNT.	Dioxins	106-112	aryl hydrocarbon receptor nuclear translocator	Mus musculus	6-10
21781780-6	1997	Since ARNT is a heterodimerization partner of the AhR required for binding of the ligand-activated AhR to dioxin-responsive elements on DNA in the nucleus to transactivate genes controlled by the AhR, an alternative mechanism for TCDD"s action is discussed which does not require ARNT.	Dioxins	106-112	aryl-hydrocarbon receptor	Mus musculus	50-53
21781780-6	1997	Since ARNT is a heterodimerization partner of the AhR required for binding of the ligand-activated AhR to dioxin-responsive elements on DNA in the nucleus to transactivate genes controlled by the AhR, an alternative mechanism for TCDD"s action is discussed which does not require ARNT.	Dioxins	106-112	aryl-hydrocarbon receptor	Mus musculus	99-102
21781780-6	1997	Since ARNT is a heterodimerization partner of the AhR required for binding of the ligand-activated AhR to dioxin-responsive elements on DNA in the nucleus to transactivate genes controlled by the AhR, an alternative mechanism for TCDD"s action is discussed which does not require ARNT.	Dioxins	106-112	aryl-hydrocarbon receptor	Mus musculus	99-102
9199285-1	1997	We have studied the transcriptional regulation of the dioxin-inducible mouse CYP1A1 gene in its native chromosomal setting.	Dioxins	54-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	77-83
9199285-2	1997	We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells.	Dioxins	99-105	aryl-hydrocarbon receptor	Mus musculus	27-56
9199285-2	1997	We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells.	Dioxins	99-105	aryl-hydrocarbon receptor	Mus musculus	58-61
9199285-2	1997	We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells.	Dioxins	99-105	aryl-hydrocarbon receptor	Mus musculus	75-78
9199285-2	1997	We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells.	Dioxins	99-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	128-134
9199285-2	1997	We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells.	Dioxins	99-105	aryl-hydrocarbon receptor	Mus musculus	75-78
9139728-8	1997	Consistent with this observation, both omeprazole and dioxin responsiveness of the dioxin receptor was inhibited in mutant yeast cells expressing low levels of the molecular chaperone hsp90 that is critical for ligand binding activity.	Dioxins	54-60	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	184-189
9241662-5	1997	The prototype AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) did not affect the rates of chronic alcohol consumption in B6 or D2 mice, suggesting that dioxin-inducible metabolism does not play a major role in alcohol drinking preference.	Dioxins	55-61	aryl-hydrocarbon receptor	Mus musculus	14-17
9145908-6	1997	Transfection studies with a plasmid containing a luciferase reporter gene under control of two dioxin-responsive elements indicate an effect on AHR protein expression.	Dioxins	95-101	aryl hydrocarbon receptor	Homo sapiens	144-147
9141435-3	1997	In the absence of EGF, the accumulation of CYP3A4 and CYP1A2 messenger RNAs (mRNAs) in response to their respective inducers (rifampicin and dioxin) was dramatically decreased in subconfluent culture with respect to confluent cultures.	Dioxins	141-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49
9141435-3	1997	In the absence of EGF, the accumulation of CYP3A4 and CYP1A2 messenger RNAs (mRNAs) in response to their respective inducers (rifampicin and dioxin) was dramatically decreased in subconfluent culture with respect to confluent cultures.	Dioxins	141-147	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	54-60
9141435-6	1997	In contrast, the accumulation of CYP1A1 mRNA in response to dioxin was similar in confluent and subconfluent cultures, irrespective of the presence of EGF.	Dioxins	60-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
9083006-1	1997	To identify new proteins involved in dioxin-dependent signal transduction and transcriptional regulation, we used a yeast two-hybrid system to identify proteins that interact with the Ah receptor (AhR).	Dioxins	37-43	aryl-hydrocarbon receptor	Mus musculus	184-195
9115019-7	1997	These results indicate an adverse relation between dioxin exposure and diabetes mellitus, glucose metabolism, and insulin production.	Dioxins	51-57	insulin	Homo sapiens	114-121
9083006-1	1997	To identify new proteins involved in dioxin-dependent signal transduction and transcriptional regulation, we used a yeast two-hybrid system to identify proteins that interact with the Ah receptor (AhR).	Dioxins	37-43	aryl-hydrocarbon receptor	Mus musculus	197-200
9102211-11	1997	These findings indicate that the ligand-dependent activation and dioxin-responsive element binding of the Ah receptor required for CYP1A1 induction in HepG2 cells also can occur in ACHN cells.	Dioxins	65-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	131-137
9144457-0	1997	Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced heart defects.	Dioxins	154-160	aryl hydrocarbon receptor 1 alpha	Gallus gallus	18-43
9170146-2	1997	AHR ligands include 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin), benzo[a]pyrene, and polychlorinated and polybrominated biphenyls; the endogenous ligand is not yet known.	Dioxins	49-55	aryl hydrocarbon receptor	Homo sapiens	0-3
9144457-0	1997	Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced heart defects.	Dioxins	154-160	aryl hydrocarbon receptor 1 alpha	Gallus gallus	45-48
9144457-0	1997	Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced heart defects.	Dioxins	154-160	aryl hydrocarbon receptor nuclear translocator	Gallus gallus	54-78
9056263-2	1997	We have previously reported the purification of the transformed TCDD.receptor complex from rat liver cytosol based on binding to its dioxin-responsive enhancer sequence (DRE) and that it comprises the AhR ligand-binding monomer and its dimerization partner, ARNT.	Dioxins	133-139	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	258-262
9079689-8	1997	The expression profiles of the AHR, MOP1, and MOP2 mRNAs, coupled with the observation that they all share ARNT as a common dimeric partner, suggests that the cellular pathways mediated by MOP1 and MOP2 may influence or respond to the dioxin signaling pathway.	Dioxins	235-241	aryl hydrocarbon receptor	Homo sapiens	31-34
9079689-8	1997	The expression profiles of the AHR, MOP1, and MOP2 mRNAs, coupled with the observation that they all share ARNT as a common dimeric partner, suggests that the cellular pathways mediated by MOP1 and MOP2 may influence or respond to the dioxin signaling pathway.	Dioxins	235-241	MOP-1	Homo sapiens	36-40
9079689-8	1997	The expression profiles of the AHR, MOP1, and MOP2 mRNAs, coupled with the observation that they all share ARNT as a common dimeric partner, suggests that the cellular pathways mediated by MOP1 and MOP2 may influence or respond to the dioxin signaling pathway.	Dioxins	235-241	endothelial PAS domain protein 1	Homo sapiens	46-50
9079689-8	1997	The expression profiles of the AHR, MOP1, and MOP2 mRNAs, coupled with the observation that they all share ARNT as a common dimeric partner, suggests that the cellular pathways mediated by MOP1 and MOP2 may influence or respond to the dioxin signaling pathway.	Dioxins	235-241	MOP-1	Homo sapiens	189-193
9079689-8	1997	The expression profiles of the AHR, MOP1, and MOP2 mRNAs, coupled with the observation that they all share ARNT as a common dimeric partner, suggests that the cellular pathways mediated by MOP1 and MOP2 may influence or respond to the dioxin signaling pathway.	Dioxins	235-241	endothelial PAS domain protein 1	Homo sapiens	198-202
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Dioxins	81-87	aryl-hydrocarbon receptor	Mus musculus	97-100
9134010-1	1997	The results demonstrate different modes of action by a dioxin-like polychlorinated biphenyl (PCB 126) and a non dioxin-like PCB (PCB 153) in the alteration of connexin (cx) 26 and cx 32 expression outside GST-P positive foci in liver of female Sprague-Dawley rats, treated according to an initiation-promotion protocol.	Dioxins	55-61	pyruvate carboxylase	Rattus norvegicus	93-96
9134010-1	1997	The results demonstrate different modes of action by a dioxin-like polychlorinated biphenyl (PCB 126) and a non dioxin-like PCB (PCB 153) in the alteration of connexin (cx) 26 and cx 32 expression outside GST-P positive foci in liver of female Sprague-Dawley rats, treated according to an initiation-promotion protocol.	Dioxins	55-61	glutathione S-transferase pi 1	Rattus norvegicus	205-210
9134010-1	1997	The results demonstrate different modes of action by a dioxin-like polychlorinated biphenyl (PCB 126) and a non dioxin-like PCB (PCB 153) in the alteration of connexin (cx) 26 and cx 32 expression outside GST-P positive foci in liver of female Sprague-Dawley rats, treated according to an initiation-promotion protocol.	Dioxins	112-118	pyruvate carboxylase	Rattus norvegicus	124-127
9134010-1	1997	The results demonstrate different modes of action by a dioxin-like polychlorinated biphenyl (PCB 126) and a non dioxin-like PCB (PCB 153) in the alteration of connexin (cx) 26 and cx 32 expression outside GST-P positive foci in liver of female Sprague-Dawley rats, treated according to an initiation-promotion protocol.	Dioxins	112-118	pyruvate carboxylase	Rattus norvegicus	124-127
9134010-1	1997	The results demonstrate different modes of action by a dioxin-like polychlorinated biphenyl (PCB 126) and a non dioxin-like PCB (PCB 153) in the alteration of connexin (cx) 26 and cx 32 expression outside GST-P positive foci in liver of female Sprague-Dawley rats, treated according to an initiation-promotion protocol.	Dioxins	112-118	glutathione S-transferase pi 1	Rattus norvegicus	205-210
9099515-2	1997	Genetic, biochemical, and molecular biology studies have revealed that the AhR mediates the toxic and biological effects of environmentally persistent dioxins and related compounds.	Dioxins	151-158	aryl hydrocarbon receptor	Homo sapiens	75-78
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Dioxins	81-87	aryl hydrocarbon receptor nuclear translocator	Mus musculus	145-149
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Dioxins	81-87	aryl hydrocarbon receptor nuclear translocator	Mus musculus	151-161
9027741-2	1997	To answer this question we investigated an ARNT-deficient mutant cell line (Hepa1C4), which has lost its capability of responding to dioxin.	Dioxins	133-139	aryl hydrocarbon receptor nuclear translocator	Mus musculus	43-47
9059605-0	1997	Mouse dioxin-inducible Ahd4 gene.	Dioxins	6-12	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	23-27
9388007-9	1997	These groups of chemicals have been identified as environmental contaminants with major dioxin-like effects that are mediated by a common receptor, the arylhydrocarbon (Ah) receptor.	Dioxins	88-94	aryl hydrocarbon receptor 1 alpha	Gallus gallus	152-181
9291492-5	1997	Our results indicate that the non-dioxin like PCB (ortho-substituted one) is active in vitro and perturbed signal transduction mechanism including Ca(2+)-homeostasis and PKC translocation.	Dioxins	34-40	pyruvate carboxylase	Rattus norvegicus	46-49
9068062-2	1997	The discovery of a DRE in the region raised the possibility that PHS-2 could be induced by TCDD, a dioxin compound.	Dioxins	99-105	dominant reduced ear	Mus musculus	19-22
9068062-2	1997	The discovery of a DRE in the region raised the possibility that PHS-2 could be induced by TCDD, a dioxin compound.	Dioxins	99-105	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
9149374-10	1997	In rat liver slices, at 72 h, CYP1A1/1A2 activity was induced 4-fold by beta NF and 37-fold by dioxin (TCDD) whereas in mouse liver slices, 1A1/1A2 activity was not inducible by beta NF but was induced 19-fold by TCDD.	Dioxins	95-101	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-36
9149374-10	1997	In rat liver slices, at 72 h, CYP1A1/1A2 activity was induced 4-fold by beta NF and 37-fold by dioxin (TCDD) whereas in mouse liver slices, 1A1/1A2 activity was not inducible by beta NF but was induced 19-fold by TCDD.	Dioxins	95-101	serine (or cysteine) peptidase inhibitor, clade A, member 3C	Mus musculus	33-36
8986142-3	1996	Certain ellipticine derivatives have been reported to bind to the AhR and inhibit the ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to transform the AhR to a form that recognizes a dioxin-responsive enhancer element (DRE) upstream of the cytochrome P4501A1 gene.	Dioxins	126-132	aryl hydrocarbon receptor	Homo sapiens	157-160
8950195-1	1996	The environmental contaminant dioxin exerts most of its effects by activating the aryl hydrocarbon receptor (AhR).	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	82-107
8950195-1	1996	The environmental contaminant dioxin exerts most of its effects by activating the aryl hydrocarbon receptor (AhR).	Dioxins	30-36	aryl hydrocarbon receptor	Homo sapiens	109-112
8948497-6	1996	Treatment with dioxin induced both CYP1A1 and CYP1A2 in liver, but only CYP1A1 in lung.	Dioxins	15-21	cytochrome P450 family 1 subfamily A member 1	Callithrix jacchus	35-41
8948497-6	1996	Treatment with dioxin induced both CYP1A1 and CYP1A2 in liver, but only CYP1A1 in lung.	Dioxins	15-21	cytochrome P450 1A2	Callithrix jacchus	46-52
8948497-6	1996	Treatment with dioxin induced both CYP1A1 and CYP1A2 in liver, but only CYP1A1 in lung.	Dioxins	15-21	cytochrome P450 family 1 subfamily A member 1	Callithrix jacchus	72-78
8937980-3	1996	Analysis of the CYP1A1 promoter has identified dioxin responsive enhancer elements which mediate the induction response.	Dioxins	47-53	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	16-22
8917696-0	1996	Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.	Dioxins	0-6	FBJ osteosarcoma oncogene	Mus musculus	32-35
8917696-0	1996	Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	53-64
8920755-8	1996	In the present study, all stimulated lymphocyte cultures showed a significant increase of CYP1A1 activity at dioxin concentrations of 10(-7) and 10(-9) M. In contrast, alterations in surface antigen expression or suppression of proliferative responses did not occur in the mitogen-activated PBL over the whole concentration range of TCDD.	Dioxins	109-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
8901557-7	1996	Complements of the xenobiotic-responsive element (XRE-AhR) in the dioxin-inducible human and rat CYP1A1 genes also exist in all four promoters, suggesting that these genes may be regulated by dioxin.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	54-57
8901557-7	1996	Complements of the xenobiotic-responsive element (XRE-AhR) in the dioxin-inducible human and rat CYP1A1 genes also exist in all four promoters, suggesting that these genes may be regulated by dioxin.	Dioxins	66-72	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	97-103
8901557-7	1996	Complements of the xenobiotic-responsive element (XRE-AhR) in the dioxin-inducible human and rat CYP1A1 genes also exist in all four promoters, suggesting that these genes may be regulated by dioxin.	Dioxins	192-198	aryl hydrocarbon receptor	Homo sapiens	54-57
8901557-7	1996	Complements of the xenobiotic-responsive element (XRE-AhR) in the dioxin-inducible human and rat CYP1A1 genes also exist in all four promoters, suggesting that these genes may be regulated by dioxin.	Dioxins	192-198	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	97-103
8816435-0	1996	Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.	Dioxins	44-50	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	116-120
8831706-0	1996	Dioxin activates human immunodeficiency virus-1 expression in chronically infected promonocytic U1 cells by enhancing NF-kappa B activity and production of tumor necrosis factor-alpha.	Dioxins	0-6	nuclear factor kappa B subunit 1	Homo sapiens	118-128
8831706-3	1996	This effect of dioxin is mediated, in part, via activation of nuclear factor kappa-B (NF-kappa B), a key cellular transcription factor that plays an important role in the induction of HIV genes and cytokine genes that regulate HIV-replication.	Dioxins	15-21	nuclear factor kappa B subunit 1	Homo sapiens	62-84
8831706-3	1996	This effect of dioxin is mediated, in part, via activation of nuclear factor kappa-B (NF-kappa B), a key cellular transcription factor that plays an important role in the induction of HIV genes and cytokine genes that regulate HIV-replication.	Dioxins	15-21	nuclear factor kappa B subunit 1	Homo sapiens	86-96
8831706-4	1996	Dioxin stimulated the production of tumor necrosis-alpha in U1 cells, and pentoxifylline, an inhibitor of TNF-alpha synthesis, inhibited dioxin induced HIV production and TNF-alpha.	Dioxins	137-143	tumor necrosis factor	Homo sapiens	106-115
8831706-4	1996	Dioxin stimulated the production of tumor necrosis-alpha in U1 cells, and pentoxifylline, an inhibitor of TNF-alpha synthesis, inhibited dioxin induced HIV production and TNF-alpha.	Dioxins	137-143	tumor necrosis factor	Homo sapiens	171-180
8765475-10	1996	TCDD treatment of splenocytes induced binding of the AhR nuclear complex to the dioxin-responsive enhancer (DRE) as detected by the electrophoretic mobility shift assay.	Dioxins	80-86	aryl-hydrocarbon receptor	Mus musculus	53-56
8806883-0	1996	Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.	Dioxins	87-93	aryl-hydrocarbon receptor	Mus musculus	0-25
8843409-2	1996	The PCBs, in common with other compounds such as the dioxins, have been shown to exert some biological actions mediated through the aryl hydrocarbon receptor.	Dioxins	53-60	aryl hydrocarbon receptor	Homo sapiens	132-157
8806843-1	1996	In the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals, the Ah receptor nuclear translocator (Arnt) forms a heterodimeric complex with the ligand-bound Ah receptor, leading to recognition of dioxin-responsive elements within the enhancer of the CYP1A1 gene and transcription activation by an unknown mechanism.	Dioxins	48-54	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	89-121
8806843-1	1996	In the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals, the Ah receptor nuclear translocator (Arnt) forms a heterodimeric complex with the ligand-bound Ah receptor, leading to recognition of dioxin-responsive elements within the enhancer of the CYP1A1 gene and transcription activation by an unknown mechanism.	Dioxins	48-54	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	123-127
8806843-1	1996	In the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals, the Ah receptor nuclear translocator (Arnt) forms a heterodimeric complex with the ligand-bound Ah receptor, leading to recognition of dioxin-responsive elements within the enhancer of the CYP1A1 gene and transcription activation by an unknown mechanism.	Dioxins	48-54	aryl hydrocarbon receptor	Homo sapiens	89-100
8806843-1	1996	In the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals, the Ah receptor nuclear translocator (Arnt) forms a heterodimeric complex with the ligand-bound Ah receptor, leading to recognition of dioxin-responsive elements within the enhancer of the CYP1A1 gene and transcription activation by an unknown mechanism.	Dioxins	48-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	274-280
8653805-2	1996	AhR complexes were incubated with [32P]dioxin responsive element (DRE) (26-mer) or bromodeoxyuridine (BrdU)-DRE and the resulting protein-DNA or crosslinked protein-DNA complexes were treated with trypsin or V8 protease and analyzed by electrophoresis.	Dioxins	39-45	aryl-hydrocarbon receptor	Mus musculus	0-3
8920755-2	1996	More recently, a dose-dependent decrease of specific subpopulations of mitogen-activated human peripheral blood lymphocytes (PBL), including helper-inducer/memory cells (CD4+CD29+) and B cells (CD20+), was reported after in vitro treatment with dioxin concentrations as low as 10(-12)-10(-14) M TCDD [1].	Dioxins	245-251	CD4 molecule	Homo sapiens	170-173
8920755-2	1996	More recently, a dose-dependent decrease of specific subpopulations of mitogen-activated human peripheral blood lymphocytes (PBL), including helper-inducer/memory cells (CD4+CD29+) and B cells (CD20+), was reported after in vitro treatment with dioxin concentrations as low as 10(-12)-10(-14) M TCDD [1].	Dioxins	245-251	keratin 20	Homo sapiens	194-198
8650695-0	1996	Overlapping but unique DNA binding specificities of the Ah receptor and constitutive dioxin-responsive element binding proteins from human keratinocytes.	Dioxins	85-91	aryl hydrocarbon receptor	Homo sapiens	56-67
8619634-7	1996	The ability of the AhR to specifically interact with dioxin-responsive elements (DRE) was demonstrated utilizing wild-type and two mutant DREs in gel shift assays.	Dioxins	53-59	aryl hydrocarbon receptor	Homo sapiens	19-22
8628610-11	1996	However, when corrected for confounders, the psychomotor score of the 66% highest-exposed breastfed infants ( > 756 pg total PCB-dioxin toxic equivalent) was negatively influenced by this postnatal exposure to PCBs and dioxins, and was comparable to the psychomotor score of the formula-fed infants.	Dioxins	132-138	pyruvate carboxylase	Homo sapiens	128-131
8626473-1	1996	Relationship to dioxin-induced CYP1A1 transcription in vivo.	Dioxins	16-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-37
8626473-4	1996	The AhR/Arnt heterodimer induces transcription by binding to dioxin-responsive elements (DREs) within an enhancer upstream of the CYP1A1 gene.	Dioxins	61-67	aryl-hydrocarbon receptor	Mus musculus	4-7
8626473-4	1996	The AhR/Arnt heterodimer induces transcription by binding to dioxin-responsive elements (DREs) within an enhancer upstream of the CYP1A1 gene.	Dioxins	61-67	aryl hydrocarbon receptor nuclear translocator	Mus musculus	8-12
8626473-4	1996	The AhR/Arnt heterodimer induces transcription by binding to dioxin-responsive elements (DREs) within an enhancer upstream of the CYP1A1 gene.	Dioxins	61-67	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	130-136
8812265-2	1996	Many of these responses are mediated by the Ah receptor (AhR) and are modulated by the interaction of the PCDH:AhR complex with its DNA recognition sequence (the dioxin-responsive element (DRE)).	Dioxins	162-168	aryl hydrocarbon receptor	Homo sapiens	44-55
8812265-2	1996	Many of these responses are mediated by the Ah receptor (AhR) and are modulated by the interaction of the PCDH:AhR complex with its DNA recognition sequence (the dioxin-responsive element (DRE)).	Dioxins	162-168	aryl hydrocarbon receptor	Homo sapiens	57-60
8812265-2	1996	Many of these responses are mediated by the Ah receptor (AhR) and are modulated by the interaction of the PCDH:AhR complex with its DNA recognition sequence (the dioxin-responsive element (DRE)).	Dioxins	162-168	aryl hydrocarbon receptor	Homo sapiens	111-114
8631128-1	1996	Cytochrome CYP1A1 gene expression, induced by polycyclic aromatic hydrocarbons and dioxins, eg.	Dioxins	83-90	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	11-17
8646792-3	1996	Here, by computer analysis of available promoter sequences, we identify dioxin-responsive elements in the promoter regions of many putative AhR regulated and therefore dioxin-inducible genes.	Dioxins	72-78	aryl hydrocarbon receptor	Homo sapiens	140-143
8646792-3	1996	Here, by computer analysis of available promoter sequences, we identify dioxin-responsive elements in the promoter regions of many putative AhR regulated and therefore dioxin-inducible genes.	Dioxins	168-174	aryl hydrocarbon receptor	Homo sapiens	140-143
8634152-7	1996	Mouse AHD3 mRNA levels are increased by dioxin in mouse Hepa-1c1c7 hepatoma wild-type (wt) cells but not in the Ah receptor nuclear translocator (ARNT)-defective (c4) mutant line, indicating that the induction process is mediated by the Ah (aromatic hydrocarbon) dioxin-binding receptor.	Dioxins	40-46	aldehyde dehydrogenase family 3, subfamily A2	Mus musculus	6-10
8619888-1	1996	Dioxin induces biological responses through interaction with a specific intracellular receptor, the Ah receptor, and the subsequent interaction of the Ah receptor with chromatin.	Dioxins	0-6	aryl hydrocarbon receptor	Oryctolagus cuniculus	100-111
8619888-1	1996	Dioxin induces biological responses through interaction with a specific intracellular receptor, the Ah receptor, and the subsequent interaction of the Ah receptor with chromatin.	Dioxins	0-6	aryl hydrocarbon receptor	Oryctolagus cuniculus	151-162
21781665-4	1996	In the PCB mixtures Arochlor 1254 and Clophen A50, potent dioxin-like non-ortho PCBs and polychlorinated dibenzofurans (PCDFs) were found in minor amounts.	Dioxins	58-64	pyruvate carboxylase	Rattus norvegicus	7-10
8907236-0	1996	Approach to risk assessment of chlorinated dioxins from Yusho PCB poisoning.	Dioxins	43-50	pyruvate carboxylase	Homo sapiens	62-65
8723035-4	1996	The AhR bioassay uses Hepa 1c1c7 wild-type cells transiently transfected with a dioxin response element regulated luciferase reporter gene.	Dioxins	80-86	aryl-hydrocarbon receptor	Mus musculus	4-7
8524325-0	1996	Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	15-21
8970722-5	1996	Our objective is to review the Ah receptor"s role in regulation of xenobiotic metabolism and use this model as a framework for understanding the less well-characterized mechanism of dioxin toxicity.	Dioxins	182-188	aryl hydrocarbon receptor	Homo sapiens	31-42
8806052-5	1996	Furthermore, to elucidate the role of the dioxin Ah locus on alterations of PC activity by TCDD, we utilized C57BL/6J (Ahb/b, Ah high TCDD affinity) mice and a congenic (Ahd/d, AH low TCDD affinity) mouse strain.	Dioxins	42-48	pyruvate carboxylase	Mus musculus	76-78
8524325-0	1996	Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	49-78
8524325-1	1996	We have analyzed the dioxin-inducible transcriptional control mechanism for the mouse CYP1A1 gene in its native chromosomal context.	Dioxins	21-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	86-92
8524325-7	1996	In addition, our studies demonstrate that dioxin-induced changes in chromatin structure occur by different mechanisms at the CYP1A1 enhancer and promoter and that events at an enhancer can be experimentally dissociated from events at the cognate promoter during mechanistic analyses of mammalian transcription in vivo.	Dioxins	42-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	125-131
7592839-4	1995	To validate the selection-amplification protocol, we demonstrated the preference of the AHR.ARNT complex for the sequence commonly found in dioxin-responsive enhancers in vivo (TNGCGTG).	Dioxins	140-146	aryl hydrocarbon receptor	Homo sapiens	88-91
8849333-1	1995	We have studied three Phase II genes in the mouse dioxin-inducible [Ah] battery: Nmo1 [encoding NAD(P)H:menadione oxidoreductase], Ahd4 (encoding the cytosolic aldehyde dehydrogenase ALDH3c), and Ugt1*06 (a UDP glucuronosyltransferase).	Dioxins	50-56	NAD(P)H dehydrogenase, quinone 1	Mus musculus	81-85
8849333-1	1995	We have studied three Phase II genes in the mouse dioxin-inducible [Ah] battery: Nmo1 [encoding NAD(P)H:menadione oxidoreductase], Ahd4 (encoding the cytosolic aldehyde dehydrogenase ALDH3c), and Ugt1*06 (a UDP glucuronosyltransferase).	Dioxins	50-56	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	196-203
8741762-3	1995	Dioxins exert their effects through a ligand activated transcription factor termed the dioxin or aryl hydrocarbon receptor (Ahr), which acts in concert with another structurally related protein: the aryl hydrocarbon nuclear translocator (Arnt).	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	97-122
8741762-3	1995	Dioxins exert their effects through a ligand activated transcription factor termed the dioxin or aryl hydrocarbon receptor (Ahr), which acts in concert with another structurally related protein: the aryl hydrocarbon nuclear translocator (Arnt).	Dioxins	0-7	aryl hydrocarbon receptor	Rattus norvegicus	124-127
8741762-3	1995	Dioxins exert their effects through a ligand activated transcription factor termed the dioxin or aryl hydrocarbon receptor (Ahr), which acts in concert with another structurally related protein: the aryl hydrocarbon nuclear translocator (Arnt).	Dioxins	0-7	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	238-242
7592839-4	1995	To validate the selection-amplification protocol, we demonstrated the preference of the AHR.ARNT complex for the sequence commonly found in dioxin-responsive enhancers in vivo (TNGCGTG).	Dioxins	140-146	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	92-96
8520928-3	1995	In order to investigate an association between dietary intake and PCB and dioxin levels in human milk and PCB levels in maternal and cord plasma, the food intake of 418 Dutch women during pregnancy was recorded using semi-quantitative food frequency questionnaires.	Dioxins	74-80	pyruvate carboxylase	Homo sapiens	66-69
8666036-3	1995	In contrast, all the cell lines expressed the nuclear Ah receptor complex (167.1-24.5 fmol/mg protein) which bound to a 32P-labeled consensus dioxin responsive element (DRE) in a gel mobility shift assay.	Dioxins	142-148	aryl hydrocarbon receptor	Homo sapiens	54-65
7488247-1	1995	The aryl hydrocarbon receptor (AHR) mediates dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin)-induced transcriptional activation of a battery of genes by interaction with a cofactor, called aryl hydrocarbon receptor nuclear translocator (ARNT) protein.	Dioxins	45-51	spineless	Drosophila melanogaster	31-34
7488247-1	1995	The aryl hydrocarbon receptor (AHR) mediates dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin)-induced transcriptional activation of a battery of genes by interaction with a cofactor, called aryl hydrocarbon receptor nuclear translocator (ARNT) protein.	Dioxins	45-51	aryl hydrocarbon receptor nuclear translocator	Mus musculus	234-238
7498094-5	1995	The toxic equivalency factor (TEF) method was used to calculate body burdens of dioxins in humans.	Dioxins	80-87	TEF transcription factor, PAR bZIP family member	Homo sapiens	4-28
8536350-0	1995	Toxicity of dioxins: role of an absolute hardness-absolute electronegativity diagram (eta-chi diagram) as a new measure in risk assessment.	Dioxins	12-19	endothelin receptor type A	Homo sapiens	86-89
8536350-2	1995	The absolute hardness, eta, of dioxins shows a good correlation with the potency of biological activity and the chlorine substitution pattern.	Dioxins	31-38	endothelin receptor type A	Homo sapiens	23-26
8536350-5	1995	Moreover, we show that the absolute hardness-absolute electronegativity (eta-chi) diagrams, as an activity coordinate, play an important role as a new measure in the assessment of the toxicity and potency of the biological activity of dioxins.	Dioxins	235-242	endothelin receptor type A	Homo sapiens	73-76
7498094-5	1995	The toxic equivalency factor (TEF) method was used to calculate body burdens of dioxins in humans.	Dioxins	80-87	TEF transcription factor, PAR bZIP family member	Homo sapiens	30-33
7980646-10	1994	Evidence from in vivo methylation protection indicated that two G residues flanking AhRE3, one of which is required for binding of the 95-kDa protein, may be protected from methylation in uninduced cells and become exposed upon dioxin treatment, suggesting that the 95-kDa protein may be constitutively bound to AhRE3, and be displaced by binding of the Ah receptor complex.	Dioxins	228-234	aryl-hydrocarbon receptor	Mus musculus	354-365
7492734-0	1995	Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: model validation and Ah receptor characterization.	Dioxins	67-74	aryl hydrocarbon receptor	Homo sapiens	123-134
7492734-0	1995	Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: model validation and Ah receptor characterization.	Dioxins	67-73	aryl hydrocarbon receptor	Homo sapiens	123-134
7540335-6	1995	In addition, the induction of the dioxin-responsive genes UDP-glucuronosyltransferase-1 (UGT1) and cytochrome P450 1A1 (CYP1A1) in liver were measured using reverse-transcriptase-polymerase chain reaction (RT-PCR).	Dioxins	34-40	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	58-87
7540335-6	1995	In addition, the induction of the dioxin-responsive genes UDP-glucuronosyltransferase-1 (UGT1) and cytochrome P450 1A1 (CYP1A1) in liver were measured using reverse-transcriptase-polymerase chain reaction (RT-PCR).	Dioxins	34-40	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	89-93
7540335-6	1995	In addition, the induction of the dioxin-responsive genes UDP-glucuronosyltransferase-1 (UGT1) and cytochrome P450 1A1 (CYP1A1) in liver were measured using reverse-transcriptase-polymerase chain reaction (RT-PCR).	Dioxins	34-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	99-118
7540335-6	1995	In addition, the induction of the dioxin-responsive genes UDP-glucuronosyltransferase-1 (UGT1) and cytochrome P450 1A1 (CYP1A1) in liver were measured using reverse-transcriptase-polymerase chain reaction (RT-PCR).	Dioxins	34-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-126
7732381-1	1995	The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin.	Dioxins	135-141	aryl-hydrocarbon receptor	Mus musculus	4-34
7732381-1	1995	The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin.	Dioxins	135-141	aryl-hydrocarbon receptor	Mus musculus	36-39
7601078-1	1995	The study investigated the effects of chronic inhalative low-level exposure to dioxins in day-care centers containing wood treated with preservatives on (1) the number of peripheral CD4 and CD8 cells and the CD4:CD8 ratio in peripheral blood and (2) the delayed-type hypersensitivity reaction of the skin (Multitest Mereux).	Dioxins	79-86	CD4 molecule	Homo sapiens	182-185
7601078-1	1995	The study investigated the effects of chronic inhalative low-level exposure to dioxins in day-care centers containing wood treated with preservatives on (1) the number of peripheral CD4 and CD8 cells and the CD4:CD8 ratio in peripheral blood and (2) the delayed-type hypersensitivity reaction of the skin (Multitest Mereux).	Dioxins	79-86	CD8a molecule	Homo sapiens	190-193
7601078-1	1995	The study investigated the effects of chronic inhalative low-level exposure to dioxins in day-care centers containing wood treated with preservatives on (1) the number of peripheral CD4 and CD8 cells and the CD4:CD8 ratio in peripheral blood and (2) the delayed-type hypersensitivity reaction of the skin (Multitest Mereux).	Dioxins	79-86	CD4 molecule	Homo sapiens	208-211
7601078-1	1995	The study investigated the effects of chronic inhalative low-level exposure to dioxins in day-care centers containing wood treated with preservatives on (1) the number of peripheral CD4 and CD8 cells and the CD4:CD8 ratio in peripheral blood and (2) the delayed-type hypersensitivity reaction of the skin (Multitest Mereux).	Dioxins	79-86	CD8a molecule	Homo sapiens	212-215
7784623-1	1995	The EPA-recommended toxicity equivalence factor (TEF) approach to estimating the lifetime incremental cancer risks for dioxins does not address (a) differences in the severity of toxicity according to the composition of chemical mixture and (b) potentials for modification of tissue-level doses of congeners in mixtures and consequently the cancer risk estimates.	Dioxins	119-126	TEF transcription factor, PAR bZIP family member	Homo sapiens	49-52
7600448-13	1995	The AHR in D2 fetal cells was able to activate a transfected chloramphenicol acetyltransferase linked to a dioxin-responsive element nucleotide sequence (DRE-CAT) when the cells were treated with TCDD or MC.	Dioxins	107-113	aryl-hydrocarbon receptor	Mus musculus	4-7
7494865-4	1995	Molecular biology studies show that TCDD inhibited 17 beta-estradiol-induced cathepsin D gene expression by targeted interaction of the nuclear Ah receptor with imperfect dioxin responsive elements strategically located within the estrogen receptor-Sp1 enhancer sequence of this gene.	Dioxins	171-177	cathepsin D	Homo sapiens	77-88
7718310-11	1994	In pregnant women, a significant negative correlation was found between some dioxin and PCB congeners in milk and plasma thyroid hormones, while newborn infants showed higher thyroid stimulating hormone (TSH) at higher levels of dioxin exposure.	Dioxins	77-83	pyruvate carboxylase	Homo sapiens	88-91
7969169-2	1994	The latent dioxin receptor responds to dioxin signalling by forming an activated heterodimeric complex with a specific bHLH partner, Arnt, an essential process for target DNA recognition.	Dioxins	11-17	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	133-137
7969169-10	1994	Moreover, within the context of the dioxin response element (xenobiotic response element), the C terminus of Arnt conferred a potent, dominating transactivation function onto the native bHLH heterodimeric complex.	Dioxins	36-42	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	109-113
7704040-0	1994	Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels.	Dioxins	6-12	NAD(P)H dehydrogenase, quinone 1	Mus musculus	58-62
7704040-6	1994	The Nmo1 gene is highly inducible by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (dioxin; TCDD) in mouse liver and mouse cell cultures.	Dioxins	67-73	NAD(P)H dehydrogenase, quinone 1	Mus musculus	4-8
7961644-1	1994	The genetic difference in the susceptibility of mice to environmental toxicities induced by dioxin and related chemicals is governed by polymorphism of the arylhydrocarbon receptor (AhR) (Poland, A., and Knutson, C. (1982) Annu.	Dioxins	92-98	aryl-hydrocarbon receptor	Mus musculus	156-180
7961644-1	1994	The genetic difference in the susceptibility of mice to environmental toxicities induced by dioxin and related chemicals is governed by polymorphism of the arylhydrocarbon receptor (AhR) (Poland, A., and Knutson, C. (1982) Annu.	Dioxins	92-98	aryl-hydrocarbon receptor	Mus musculus	182-185
7818291-6	1994	The PCB contribution to "dioxin-like" effects among high consumers of fish (calculated as Nordic TCDD equivalents) was almost 80%, whereas that from PCDD and PCDF was only 20%.	Dioxins	25-31	pyruvate carboxylase	Homo sapiens	4-7
7482546-8	1995	Comprehensive risk assessments of dioxins should include all Ah receptor ligands such as the halogenated dibenzofurans and biphenyls.	Dioxins	34-41	aryl hydrocarbon receptor	Homo sapiens	61-72
7628454-1	1995	Gene regulation by dioxins is mediated by the dioxin receptor-Arnt heterodimer, a ligand generated complex of two basic helix-loop-helix (bHLH)/Per-Arnt-Sim (PAS) transcription factors.	Dioxins	19-26	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	62-66
7628454-1	1995	Gene regulation by dioxins is mediated by the dioxin receptor-Arnt heterodimer, a ligand generated complex of two basic helix-loop-helix (bHLH)/Per-Arnt-Sim (PAS) transcription factors.	Dioxins	19-26	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	148-152
7541987-0	1995	The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.	Dioxins	113-119	aryl hydrocarbon receptor	Homo sapiens	4-15
7541987-0	1995	The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.	Dioxins	113-119	paired box 5	Homo sapiens	82-86
7541987-0	1995	The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.	Dioxins	113-119	CD19 molecule	Homo sapiens	143-147
7486986-6	1995	Dioxin-inducible cytochrome P450 activity was detected for up to 58 d in culture, and albumin, fibrinogen, transferrin, and soluble fibronectin were detected in the medium by enzyme-linked immunosorbent assay (ELISA) for 48 d in vitro.	Dioxins	0-6	transferrin	Rattus norvegicus	107-118
7791778-0	1995	Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
7791778-1	1995	In mouse hepatoma cells, the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) induces Cyp1A1 gene transcription, a process that requires two basic helix-loop-helix regulatory proteins, the aromatic hydrocarbon receptor (AhR) and the aromatic hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	84-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	117-123
7791778-1	1995	In mouse hepatoma cells, the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) induces Cyp1A1 gene transcription, a process that requires two basic helix-loop-helix regulatory proteins, the aromatic hydrocarbon receptor (AhR) and the aromatic hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	84-90	aryl-hydrocarbon receptor	Mus musculus	220-249
7791778-1	1995	In mouse hepatoma cells, the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) induces Cyp1A1 gene transcription, a process that requires two basic helix-loop-helix regulatory proteins, the aromatic hydrocarbon receptor (AhR) and the aromatic hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	84-90	aryl-hydrocarbon receptor	Mus musculus	251-254
7791778-1	1995	In mouse hepatoma cells, the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) induces Cyp1A1 gene transcription, a process that requires two basic helix-loop-helix regulatory proteins, the aromatic hydrocarbon receptor (AhR) and the aromatic hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	84-90	aryl hydrocarbon receptor nuclear translocator	Mus musculus	264-314
7791778-1	1995	In mouse hepatoma cells, the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) induces Cyp1A1 gene transcription, a process that requires two basic helix-loop-helix regulatory proteins, the aromatic hydrocarbon receptor (AhR) and the aromatic hydrocarbon receptor nuclear translocator (Arnt).	Dioxins	84-90	aryl hydrocarbon receptor nuclear translocator	Mus musculus	316-320
7791778-2	1995	We have used a ligation-mediated PCR technique to analyze dioxin-induced changes in protein-DNA interactions and chromatin structure of the Cyp1A1 enhancer-promoter in its native chromosomal setting.	Dioxins	58-64	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	140-146
7791778-3	1995	Dioxin-induced binding of the AhR/Arnt heteromer to enhancer chromatin is associated with a localized (about 200 bp) alteration in chromatin structure that is manifested by increased accessibility of the DNA; these changes probably reflect direct disruption of a nucleosome by AhR/Arnt.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	30-33
7791778-3	1995	Dioxin-induced binding of the AhR/Arnt heteromer to enhancer chromatin is associated with a localized (about 200 bp) alteration in chromatin structure that is manifested by increased accessibility of the DNA; these changes probably reflect direct disruption of a nucleosome by AhR/Arnt.	Dioxins	0-6	aryl hydrocarbon receptor nuclear translocator	Mus musculus	34-38
7791778-3	1995	Dioxin-induced binding of the AhR/Arnt heteromer to enhancer chromatin is associated with a localized (about 200 bp) alteration in chromatin structure that is manifested by increased accessibility of the DNA; these changes probably reflect direct disruption of a nucleosome by AhR/Arnt.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	277-280
7791778-3	1995	Dioxin-induced binding of the AhR/Arnt heteromer to enhancer chromatin is associated with a localized (about 200 bp) alteration in chromatin structure that is manifested by increased accessibility of the DNA; these changes probably reflect direct disruption of a nucleosome by AhR/Arnt.	Dioxins	0-6	aryl hydrocarbon receptor nuclear translocator	Mus musculus	281-285
7791778-4	1995	Dioxin induces analogous AhR/Arnt-dependent changes in chromatin structure and accessibility at the Cyp1A1 promoter.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	25-28
7791778-4	1995	Dioxin induces analogous AhR/Arnt-dependent changes in chromatin structure and accessibility at the Cyp1A1 promoter.	Dioxins	0-6	aryl hydrocarbon receptor nuclear translocator	Mus musculus	29-33
7791778-4	1995	Dioxin induces analogous AhR/Arnt-dependent changes in chromatin structure and accessibility at the Cyp1A1 promoter.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	100-106
7791778-6	1995	Dose-response experiments indicate that the changes in chromatin structure at the enhancer and promoter are graded and mirror the graded induction of Cyp1A1 transcription by dioxin.	Dioxins	174-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	150-156
7775458-3	1995	Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that enables the dioxin-(2,3,7,8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor complex to recognize dioxin response elements of target promoters.	Dioxins	58-64	tango	Drosophila melanogaster	0-4
7775458-3	1995	Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that enables the dioxin-(2,3,7,8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor complex to recognize dioxin response elements of target promoters.	Dioxins	58-64	tango	Drosophila melanogaster	157-161
7775458-3	1995	Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that enables the dioxin-(2,3,7,8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor complex to recognize dioxin response elements of target promoters.	Dioxins	102-108	tango	Drosophila melanogaster	0-4
7775458-3	1995	Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that enables the dioxin-(2,3,7,8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor complex to recognize dioxin response elements of target promoters.	Dioxins	102-108	tango	Drosophila melanogaster	157-161
7607137-0	1995	Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	109-115
7986070-2	1994	Incubation of the radiolabeled ([3H]TCDD) 9S cytosolic Ah receptor with nuclei from untreated wild-type Ah-responsive mouse Hepa 1c1c7 cells resulted in a time- and temperature-dependent formation of the nuclear Ah receptor complex as determined by either velocity sedimentation analysis or gel mobility shift assays using a consensus 32P-labeled dioxin-responsive element.	Dioxins	347-353	aryl-hydrocarbon receptor	Mus musculus	55-66
7940984-1	1994	The aromatic hydrocarbon (AH) (dioxin) receptor was discovered almost 20 years ago and achieved notoriety as the front-line site of action of highly toxic environmental chemicals such as halogenated dioxins and polychlorinated biphenyls.	Dioxins	199-206	aryl hydrocarbon receptor	Homo sapiens	4-47
7850370-0	1994	The Dutch PCB/Dioxin Study.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	10-13
7850374-0	1994	The Dutch PCB/Dioxin Study.	Dioxins	14-20	pyruvate carboxylase	Homo sapiens	10-13
7716743-5	1994	The ligand-AhR-ARNT complex interacts with a specific, nuclear DNA sequence, the dioxin response element (DRE), altering transcription of a regulated gene.	Dioxins	81-87	aryl hydrocarbon receptor	Homo sapiens	11-14
7716743-5	1994	The ligand-AhR-ARNT complex interacts with a specific, nuclear DNA sequence, the dioxin response element (DRE), altering transcription of a regulated gene.	Dioxins	81-87	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	15-19
7883760-7	1994	The human AhR expressed either in COS-7 cells or in a reticulocyte lysate in vitro translation system showed specific dioxin-binding activity and Arnt-dependent DNA-binding activity.	Dioxins	118-124	aryl hydrocarbon receptor	Homo sapiens	10-13
7812217-0	1994	Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor.	Dioxins	0-6	aryl hydrocarbon receptor	Rattus norvegicus	89-100
8089152-1	1994	Signal transduction by dioxin is mediated by the intracellular basic helix-loop-helix dioxin receptor which, in its ligand-activated state, binds to target DNA as a heteromeric complex with the partner factor Arnt.	Dioxins	23-29	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	209-213
8034660-10	1994	These chimeric receptor constructs show dioxin responsiveness upon transient transfection into mutant Arnt-deficient hepatoma cells and are, thus, functionally uncoupled from Arnt.	Dioxins	40-46	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	102-106
7940984-2	1994	Increasing evidence suggests that the AH receptor plays a key role in proliferation and differentiation of cells exposed to dioxins and, perhaps, to endogenous ligands.	Dioxins	124-131	aryl hydrocarbon receptor	Homo sapiens	38-49
7919753-4	1994	At 11 weeks of age, alanine aminotransferase and aspartate aminotransferase activities in plasma were significantly related to cumulative dioxin intake.	Dioxins	138-144	glutamic--pyruvic transaminase	Homo sapiens	20-44
8163516-6	1994	In addition, the transformed Ah receptor bound to a specific dioxin-responsive enhancer sequence with the same apparent affinity when MC was the ligand as when TCDD was the ligand.	Dioxins	61-67	aryl-hydrocarbon receptor	Mus musculus	29-40
7909315-7	1994	The loss of Ah responsiveness in the BaPR variant cells correlated with the failure of the nuclear or transformed cytosolic Ah receptor complex to bind genomic dioxin-responsive elements as determined in gel retardation assays.	Dioxins	160-166	aryl hydrocarbon receptor	Homo sapiens	124-135
8139547-1	1994	In response to dioxin, the nuclear basic helix-loop-helix (bHLH) dioxin receptor forms a complex with the bHLH partner factor Arnt that regulates target gene transcription by binding to dioxin-responsive sequence motifs.	Dioxins	65-71	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	126-130
8139547-5	1994	Addition of a specific fraction from wild-type hepatoma cells, however, to the in vitro-expressed receptor promoted dioxin-dependent release of hsp90.	Dioxins	116-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	144-149
8139547-1	1994	In response to dioxin, the nuclear basic helix-loop-helix (bHLH) dioxin receptor forms a complex with the bHLH partner factor Arnt that regulates target gene transcription by binding to dioxin-responsive sequence motifs.	Dioxins	15-21	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	126-130
8139547-9	1994	In support of this model, addition of in vitro-expressed wild-type Arnt, but not a mutated form of Arnt lacking the bHLH motif, promoted release of hsp90 from the dioxin receptor in the presence of dioxin.	Dioxins	163-169	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	67-71
8139547-9	1994	In support of this model, addition of in vitro-expressed wild-type Arnt, but not a mutated form of Arnt lacking the bHLH motif, promoted release of hsp90 from the dioxin receptor in the presence of dioxin.	Dioxins	163-169	heat shock protein 90 alpha family class A member 1	Homo sapiens	148-153
8033869-8	1994	We offer some simple molecular recognition models to account for the importance of these different structural features in the structure-activity relationships that permit one to express PCB reactivities in terms of dioxin, thyroxine, and estradiol equivalents.	Dioxins	215-221	pyruvate carboxylase	Homo sapiens	186-189
8120057-5	1994	One region located at -2532/-2423 contains an xenobiotic-responsive element-like sequence, termed X1, that binds a nuclear 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible protein in HepG2 and wild type mouse Hepa-1 cells, but not in the Ah receptor nuclear translocation defective mouse C- mutant c4 cells.	Dioxins	152-158	aryl-hydrocarbon receptor	Mus musculus	235-246
8106494-9	1994	Thus, both dioxin- and indolocarbazole-activated forms of dioxin receptor regulate target gene expression by the same mechanism involving recruitment of the bHLH factor Arnt and recognition of the XRE element.	Dioxins	11-17	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	169-173
8187704-11	1994	Because of substantial PCB contribution to dioxin toxic equivalents, total dioxinlike toxicity can only be determined if dioxins, dibenzofurans, and dioxinlike PCBs are measured.	Dioxins	43-49	pyruvate carboxylase	Homo sapiens	23-26
8308014-13	1994	These data demonstrate that Arnt plays a central role in control of dioxin receptor function by cooperatively modulating the DNA binding activity of the receptor in vitro and dioxin-dependent transactivation in vivo.	Dioxins	68-74	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	28-32
8004128-3	1994	Transcription of the NQO1 gene is increased in response to bifunctional [e.g. beta-naphthoflavone (beta-NF), 2,3,7,8,-tetrachlordibenzo-p-dioxin (dioxin)] and monofunctional [phenolic antioxidants/chemoprotectors e.g. 2(3)tert-butyl-4-hydroxy-anisole (BHA)] inducers.	Dioxins	138-144	NAD(P)H quinone dehydrogenase 1	Homo sapiens	21-25
8004128-12	1994	Dioxin induction of the NQO1 gene expression is mediated by XRE, an element best characterized in the case of the CYP1A1 gene.	Dioxins	0-6	NAD(P)H quinone dehydrogenase 1	Homo sapiens	24-28
8004128-12	1994	Dioxin induction of the NQO1 gene expression is mediated by XRE, an element best characterized in the case of the CYP1A1 gene.	Dioxins	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	114-120
7972244-0	1994	Evidence for the role of the Ah receptor in response to dioxin.	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	29-40
7826661-0	1994	Dioxin-enhanced expression of interleukin-1 beta in human epidermal keratinocytes: potential role in the modulation of immune and inflammatory responses.	Dioxins	0-6	interleukin 1 beta	Homo sapiens	30-48
8390353-3	1993	TCDD, or dioxin as it is frequently called, interacts with the Ah receptor (AhR), which functions in a manner analogous to receptors for steroids.	Dioxins	9-15	aryl hydrocarbon receptor	Homo sapiens	63-74
8148869-0	1993	Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels.	Dioxins	6-12	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	59-63
8148869-5	1993	Surprisingly, in contrast to the rat gene that is expressed in both cell cultures and the intact liver, the murine Ahd-4 gene is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) or benzo[a]pyrene in cell cultures but not in liver of the intact adult or newborn mouse.	Dioxins	171-177	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	115-120
8251506-0	1993	Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: evidence for two distinct heteromeric DNA-binding forms.	Dioxins	48-54	aryl hydrocarbon receptor	Cavia porcellus	23-34
8251506-1	1993	Guinea pig hepatic Ah receptor (AhR) complex was transformed in vitro to its DNA-binding form by incubation with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	142-148	aryl hydrocarbon receptor	Cavia porcellus	19-30
8251506-1	1993	Guinea pig hepatic Ah receptor (AhR) complex was transformed in vitro to its DNA-binding form by incubation with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin).	Dioxins	142-148	aryl hydrocarbon receptor	Cavia porcellus	32-35
8251506-2	1993	Transformed TCDD-AhR was covalently cross-linked by UV-irradiation to a bromodeoxyuridine-substituted oligonucleotide containing its specific DNA recognition site, the dioxin responsive element (DRE).	Dioxins	168-174	aryl hydrocarbon receptor	Cavia porcellus	17-20
8223432-1	1993	The dioxin receptor mediates signal transduction by dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) and binds to DNA target sequences as a heterodimer of the approximately 100 kDa ligand binding receptor and the approximately 85 kDa auxiliary factor, Arnt.	Dioxins	4-10	aryl hydrocarbon receptor nuclear translocator	Cricetulus griseus	248-252
7504659-1	1993	Polychlorinated hydrocarbons such as biphenyls or dioxins interfere with cellular processes by gene induction via ligand-activated binding of the cytosolic Ah-receptor to specific DNA elements.	Dioxins	50-57	aryl-hydrocarbon receptor	Mus musculus	156-167
8346970-6	1993	The results demonstrate that the apparent dioxin-like potency of PCB residues in Aroclors, seals, and humans is dominated by three congeners, 3,3",4,4"-tetra-, 2,3,3"-4,4"-, and 3,3",4,4",5-pentachlorobiphenyl (IUPAC nos.	Dioxins	42-48	pyruvate carboxylase	Homo sapiens	65-68
8390353-3	1993	TCDD, or dioxin as it is frequently called, interacts with the Ah receptor (AhR), which functions in a manner analogous to receptors for steroids.	Dioxins	9-15	aryl hydrocarbon receptor	Homo sapiens	76-79
8386305-2	1993	Ligand-dependent AhR activation leads to nuclear translocation and binding of the receptor to dioxin-responsive element (DRE) sequences, an event that initiates transcriptional activation of the CYP1A1 gene.	Dioxins	94-100	aryl hydrocarbon receptor	Homo sapiens	17-20
8516763-2	1993	These include: (i) the accumulation of TCDD in the target tissue, (ii) formation of a complex between dioxin and the Ah receptor, (iii) activation of transcription of growth regulatory genes by the TCDD-Ah receptor complex, (iv) cellular events on tumor initiation, promotion, and progression.	Dioxins	102-108	aryl hydrocarbon receptor	Homo sapiens	117-128
8516763-2	1993	These include: (i) the accumulation of TCDD in the target tissue, (ii) formation of a complex between dioxin and the Ah receptor, (iii) activation of transcription of growth regulatory genes by the TCDD-Ah receptor complex, (iv) cellular events on tumor initiation, promotion, and progression.	Dioxins	102-108	aryl hydrocarbon receptor	Homo sapiens	203-214
8394802-5	1993	Much has been learned about the mechanism of dioxin"s effects, especially for the induction of cytochrome P-450 enzymes.	Dioxins	45-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-111
8394802-10	1993	The sequence in events initiated by the Ah receptor interacting with dioxin-responsive genes and ending with altered patterns of differentiation and growth must be sought in order to understand tissue, species, sex, and interindividual variation in biological responses and the health risk posed by PCDDs and PCDFs.	Dioxins	69-75	aryl hydrocarbon receptor	Homo sapiens	40-51
8384309-5	1993	Arnt also functionally reconstituted in vitro the DNA binding activity of a mutant, nuclear translocation-deficient dioxin receptor phenotype in cytosolic extracts from a dioxin-resistant hepatoma cell line.	Dioxins	116-122	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
8337704-13	1993	The present model, which relied on measured values of CYP1A2 and specified CYP1A2 as the hepatic dioxin binding species, successfully describes the hepatic disposition of TBDD, providing further evidence that CYP1A2 is the primary hepatic binding species in the rat.	Dioxins	97-103	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	75-81
8337704-13	1993	The present model, which relied on measured values of CYP1A2 and specified CYP1A2 as the hepatic dioxin binding species, successfully describes the hepatic disposition of TBDD, providing further evidence that CYP1A2 is the primary hepatic binding species in the rat.	Dioxins	97-103	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	75-81
8384216-2	1993	The DNA upstream of the dioxin-inducible CYP1A1 gene contains six distinct sites to which the liganded Ah receptor binds in intact mouse hepatoma cells.	Dioxins	24-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-47
8384216-2	1993	The DNA upstream of the dioxin-inducible CYP1A1 gene contains six distinct sites to which the liganded Ah receptor binds in intact mouse hepatoma cells.	Dioxins	24-30	aryl-hydrocarbon receptor	Mus musculus	103-114
8384853-6	1993	The ability of 13C or DIM to cause in vitro transformation of the Ah receptor to a form able to bind to the dioxin-responsive element-3 (DRE3) was compared to that of TCDD and shown to parallel their abilities to compete for binding of [3H]TCDD to the Ah receptor.	Dioxins	108-114	aryl hydrocarbon receptor	Rattus norvegicus	66-77
8381508-5	1993	Incubation of rat hepatic cytosol with 10 microM alpha NF caused transformation of the Ah receptor, as determined in a gel retardation assay using a 32P-labeled oligonucleotide containing a single dioxin-responsive element (DRE).	Dioxins	197-203	aryl hydrocarbon receptor	Rattus norvegicus	87-98
8383868-2	1993	It functions in combination with a cellular protein, the Ah receptor, to alter gene regulation, and this resulting modulation of gene expression is believed to be obligatory for both dioxin toxicity and carcinogenicity.	Dioxins	183-189	aryl hydrocarbon receptor	Rattus norvegicus	57-68
8382788-1	1993	We have used a ligation-mediated polymerase chain reaction technique to analyze protein-DNA interactions at a dioxin-responsive enhancer upstream of the CYP1A1 gene in intact mouse hepatoma cells.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	153-159
8386305-2	1993	Ligand-dependent AhR activation leads to nuclear translocation and binding of the receptor to dioxin-responsive element (DRE) sequences, an event that initiates transcriptional activation of the CYP1A1 gene.	Dioxins	94-100	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	195-201
8381755-4	1993	Established effects of exposure to dioxin are the induction of cytochrome P450-1A1 and P450-1A2 and a reduction in the maximal binding of the epidermal growth factor receptor in rat livers.	Dioxins	35-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	63-82
8381755-4	1993	Established effects of exposure to dioxin are the induction of cytochrome P450-1A1 and P450-1A2 and a reduction in the maximal binding of the epidermal growth factor receptor in rat livers.	Dioxins	35-41	epidermal growth factor receptor	Rattus norvegicus	142-174
1335178-6	1992	There is also recent evidence that this process may be responsible for the immunotoxicity of dioxins and organotin compounds and involved in the killing of adenocarcinoma cells by tumor necrosis factor alpha.	Dioxins	93-100	tumor necrosis factor	Homo sapiens	180-207
1331752-0	1992	In vitro transformation of the human Ah receptor and its binding to a dioxin response element.	Dioxins	70-76	aryl hydrocarbon receptor	Homo sapiens	37-48
1318077-0	1992	DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer.	Dioxins	70-76	aryl-hydrocarbon receptor	Mus musculus	53-64
1318077-1	1992	We have utilized gel retardation analysis and DNA mutagenesis to examine the specific interaction of transformed guinea pig hepatic cytosolic TCDD.AhR complex with a dioxin-responsive element (DRE).	Dioxins	166-172	aryl hydrocarbon receptor	Cavia porcellus	147-150
1317573-0	1992	Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	28-39
1317573-1	1992	We have analyzed dioxin-inducible, Ah receptor-dependent changes in protein-DNA interactions at the CYP1A1 transcriptional promoter in intact mouse hepatoma cells.	Dioxins	17-23	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	100-106
1317573-3	1992	Dioxin induces, in Ah receptor-dependent fashion, an increase in promoter accessibility, which occurs rapidly and does not require ongoing transcription of the CYP1A1 gene.	Dioxins	0-6	aryl hydrocarbon receptor	Homo sapiens	19-30
1321524-1	1992	Dioxins and peroxisome proliferators represent two diverse classes of xenobiotic compounds that induce transcription of specific genes encoding cytochrome P-450 drug-metabolizing enzymes.	Dioxins	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	144-160
1605850-0	1992	Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.	Dioxins	0-6	FBJ osteosarcoma oncogene	Mus musculus	29-34
1605850-0	1992	Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.	Dioxins	0-6	jun proto-oncogene	Mus musculus	39-44
1605850-0	1992	Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.	Dioxins	0-6	jun proto-oncogene	Mus musculus	106-110
1313023-2	1992	The liganded Ah receptor activates transcription by binding to a specific DNA-recognition motif within a dioxin-responsive enhancer upstream of the CYP1A1 gene.	Dioxins	105-111	aryl hydrocarbon receptor	Homo sapiens	13-24
1313023-2	1992	The liganded Ah receptor activates transcription by binding to a specific DNA-recognition motif within a dioxin-responsive enhancer upstream of the CYP1A1 gene.	Dioxins	105-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	148-154
1313025-1	1992	DNA-protein interactions before and after transcriptional activation of the carcinogen- and dioxin-inducible enhancer of the murine CYP1A1 gene were detected in vivo by treatment with dimethyl sulfate followed by ligation-mediated, polymerase chain reaction-aided genomic sequencing.	Dioxins	92-98	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	132-138
8384852-1	1993	Dioxin induces biological responses through interaction with a specific intracellular receptor, the Ah receptor, and the subsequent interaction of the Ah receptor with chromatin.	Dioxins	0-6	aryl hydrocarbon receptor	Oryctolagus cuniculus	100-111
8384852-1	1993	Dioxin induces biological responses through interaction with a specific intracellular receptor, the Ah receptor, and the subsequent interaction of the Ah receptor with chromatin.	Dioxins	0-6	aryl hydrocarbon receptor	Oryctolagus cuniculus	151-162
1331752-1	1992	Many biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) are mediated by a soluble intracellular protein, the Ah receptor (AhR).	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	131-142
1331752-1	1992	Many biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) are mediated by a soluble intracellular protein, the Ah receptor (AhR).	Dioxins	56-62	aryl hydrocarbon receptor	Homo sapiens	144-147
1331752-3	1992	The binding of transformed AhR to a specific dioxin-responsive element (DRE) upstream of a given gene stimulates transcriptional activation of that gene.	Dioxins	45-51	aryl hydrocarbon receptor	Homo sapiens	27-30
1332880-0	1992	Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer.	Dioxins	57-63	aryl-hydrocarbon receptor	Mus musculus	40-51
1332880-1	1992	The Ah receptor (AhR) mediates many, if not all, of the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related halogenated aromatic hydrocarbons.	Dioxins	117-123	aryl-hydrocarbon receptor	Mus musculus	4-15
1332880-1	1992	The Ah receptor (AhR) mediates many, if not all, of the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related halogenated aromatic hydrocarbons.	Dioxins	117-123	aryl-hydrocarbon receptor	Mus musculus	17-20
1332880-3	1992	We have examined the ability of cytosolic AhR, from a variety of species (rat, rabbit, guinea pig, hamster, mouse, cow, sheep, fish, chicken and human), to transform and bind to its cognate DNA recognition sequence, the dioxin responsive enhancer (DRE), to evaluate the importance of these events in species variations in TCDD responsiveness.	Dioxins	220-226	aryl hydrocarbon receptor	Rattus norvegicus	42-45
1322109-3	1992	The chelator 1,10-phenanthroline and its nonchelating isomers 1,7- and 4,7-phenanthroline blocked, in a concentration-dependent manner, TCDD-elicited transformation of the AhR in rat hepatic cytosol to a form which bound a dioxin-response element (DRE; upstream of the structural gene for cytochrome P4501A1).	Dioxins	223-229	aryl hydrocarbon receptor	Rattus norvegicus	172-175
1322114-5	1992	A more quantitative measure of the structure-dependent transformation of the liganded cytosolic Ah receptor complex was determined using a gel retardation assay with a consensus synthetic dioxin-responsive element (DRE) (26-mer, duplex).	Dioxins	188-194	aryl hydrocarbon receptor	Rattus norvegicus	96-107
1322574-1	1992	The numerous toxic responses of dioxin-like compounds are mediated by the intracellular Ah (aryl hydrocarbon) receptor.	Dioxins	32-38	aryl hydrocarbon receptor	Homo sapiens	92-118
1567227-0	1992	Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2.	Dioxins	74-80	cytochrome P450 1A1	Oryctolagus cuniculus	31-37
1567227-0	1992	Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2.	Dioxins	74-80	cytochrome P450 1A2	Oryctolagus cuniculus	42-48
1572081-6	1992	Significant alterations in serum triglyceride and alanine aminotransferase levels were found in guinea pigs due to exposure to dioxins.	Dioxins	127-134	glutamic--pyruvic transaminase	Homo sapiens	50-74
1312672-0	1992	Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.	Dioxins	0-6	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	38-45
1312672-1	1992	Transcriptional activation of the murine Cyp1a-1 (cytochrome P(1)450) gene by inducers such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (dioxin) requires the aromatic hydrocarbon (Ah) receptor and the interaction of an inducer-receptor complex with one or more of the Ah-responsive elements (AhREs) located about 1 kb upstream from the transcriptional initiation site.	Dioxins	124-130	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-48
1312672-1	1992	Transcriptional activation of the murine Cyp1a-1 (cytochrome P(1)450) gene by inducers such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (dioxin) requires the aromatic hydrocarbon (Ah) receptor and the interaction of an inducer-receptor complex with one or more of the Ah-responsive elements (AhREs) located about 1 kb upstream from the transcriptional initiation site.	Dioxins	124-130	aryl-hydrocarbon receptor	Mus musculus	160-194
1536575-10	1992	An unexpected finding was the presence at position -403 to -385 of a putative dioxin responsive element, a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene (CYPIA1) and other genes involved in detoxification/activation of polycyclic aromatic hydrocarbons.	Dioxins	78-84	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	207-213
1510582-4	1992	To further investigate the mechanism whereby dioxins decrease PEPCK activity, Northern analysis was performed using a cDNA probe complementary to a portion of the PEPCK mRNA.	Dioxins	45-52	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	62-67
1311272-1	1992	In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P(1)450) and Nmo-1[NAD(P)H:menadione-oxidoreductase] genes, two members of the aromatic hydrocarbon (Ah)-responsive gene battery.	Dioxins	126-132	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	161-168
1311272-1	1992	In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P(1)450) and Nmo-1[NAD(P)H:menadione-oxidoreductase] genes, two members of the aromatic hydrocarbon (Ah)-responsive gene battery.	Dioxins	126-132	NAD(P)H dehydrogenase, quinone 1	Mus musculus	194-232
1510582-4	1992	To further investigate the mechanism whereby dioxins decrease PEPCK activity, Northern analysis was performed using a cDNA probe complementary to a portion of the PEPCK mRNA.	Dioxins	45-52	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	163-168
1754392-0	1991	Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice.	Dioxins	25-31	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-24
1754392-2	1991	The Cyp1a-1 dioxin-responsive enhancer region has been previously analyzed in vitro and found to induce expression of heterologous genes upon exposure of transfected cells to various aromatic hydrocarbons.	Dioxins	12-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	4-11
1657151-0	1991	Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.	Dioxins	76-82	NAD(P)H quinone dehydrogenase 1	Homo sapiens	38-42
1656877-6	1991	Incubation of the nuclear or transformed liganded cytosolic Ah receptor from wild-type cells with a consensus 32P-labeled dioxin responsive element (DRE) in a gel shift assay gave a retarded band associated with the receptor-DRE complex.	Dioxins	122-128	aryl-hydrocarbon receptor	Mus musculus	60-71
1925598-0	1991	Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.	Dioxins	12-18	serpin family B member 2	Homo sapiens	30-63
1925598-0	1991	Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.	Dioxins	12-18	interleukin 1 beta	Homo sapiens	68-86
1652054-5	1991	The presence of the constitutive DNase I-hypersensitive sites at the dioxin response elements correlates with the presence of a constitutive, labile factor which specifically recognizes these elements in vitro.	Dioxins	69-75	deoxyribonuclease 1	Rattus norvegicus	33-40
1669971-3	1991	It appears that "dioxin"-like properties of some PCB congeners are amenable to a TEF treatment that is compatible with that used for CDDs/CDFs.	Dioxins	17-23	pyruvate carboxylase	Homo sapiens	49-52
1669971-3	1991	It appears that "dioxin"-like properties of some PCB congeners are amenable to a TEF treatment that is compatible with that used for CDDs/CDFs.	Dioxins	17-23	TEF transcription factor, PAR bZIP family member	Homo sapiens	81-84
1669971-5	1991	Other non-"dioxin"-like toxic endpoints (e.g., neurotoxicity) appear to have a different structure-activity-related mechanism-of-action that requires a separate TEF scheme.	Dioxins	11-17	TEF transcription factor, PAR bZIP family member	Homo sapiens	161-164
1949034-16	1991	The neurotoxic action of PCBs may occur by a different mechanism than PCB hepato- and immunotoxicity since these effects are most sensitive to non-ortho-substituted, dioxin-like, congeners.	Dioxins	166-172	pyruvate carboxylase	Rattus norvegicus	25-28
1646595-0	1991	The Ah receptor and the mechanism of dioxin toxicity.	Dioxins	37-43	aryl hydrocarbon receptor	Homo sapiens	4-15
1844873-0	1991	Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.	Dioxins	106-112	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
1844873-8	1991	Expression of the CYP1A1 or CYP1A2 enzyme in mouse hepatoma Hepa-1 cells lacking endogenous CYP1A1 activity represses constitutive transcription of not only the endogenous Cyp1a-1 gene but other genes in the dioxin-inducible [Ah] battery.	Dioxins	208-214	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24
1844873-8	1991	Expression of the CYP1A1 or CYP1A2 enzyme in mouse hepatoma Hepa-1 cells lacking endogenous CYP1A1 activity represses constitutive transcription of not only the endogenous Cyp1a-1 gene but other genes in the dioxin-inducible [Ah] battery.	Dioxins	208-214	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-34
1844873-8	1991	Expression of the CYP1A1 or CYP1A2 enzyme in mouse hepatoma Hepa-1 cells lacking endogenous CYP1A1 activity represses constitutive transcription of not only the endogenous Cyp1a-1 gene but other genes in the dioxin-inducible [Ah] battery.	Dioxins	208-214	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	172-179
2082180-4	1990	Measurements of steady-state mRNA levels and of transcriptional rates in the transfectants reveal that expression of a functional, exogenous CYP1A1 protein is sufficient to restore the repression of the endogenous gene, as well as restore the inducibility by dioxin, and that this effect takes place primarily at the level of transcription.	Dioxins	259-265	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	141-147
2033054-0	1991	Dioxin induces transforming growth factor-alpha in human keratinocytes.	Dioxins	0-6	tumor necrosis factor	Homo sapiens	15-47
2033054-5	1991	These results suggest that induction of TGF-alpha could be an important part of the mechanism of dioxin-mediated toxicity and tumor promotion.	Dioxins	97-103	transforming growth factor alpha	Homo sapiens	40-49
1848780-0	1991	Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation.	Dioxins	72-78	aryl hydrocarbon receptor	Rattus norvegicus	42-53
1848780-6	1991	Using the chemical cross-linking agent dimethyl pimelimidate, we further established that the 100-kDa form of the receptor (peak 1) associates with a different protein to generate the receptor form (peak 2) that binds to the dioxin-responsive enhancer.	Dioxins	225-231	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	124-130
1852076-1	1991	The aryl hydrocarbon (Ah) receptor binds various environmental pollutants, such as polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic compounds (dioxins, dibenzofurans, and biphenyls), and mediates the carcinogenic effects of these agents.	Dioxins	178-185	aryl hydrocarbon receptor	Homo sapiens	4-34
1654803-6	1991	The functional activity of the photoaffinity-labeled nuclear TCDD-Ah receptor complexes from the cell lines was also determined by comparing relative binding affinities of the photolyzed and unphotolyzed complexes with a synthetic dioxin-responsive element (DRE) using a gel retardation assay.	Dioxins	231-237	aryl hydrocarbon receptor	Homo sapiens	66-77
1899380-0	1991	The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.	Dioxins	10-16	crystallin zeta	Homo sapiens	36-58
1899380-0	1991	The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.	Dioxins	10-16	NAD(P)H quinone dehydrogenase 1	Homo sapiens	121-133
1899380-3	1991	Recently we cloned and sequenced the cDNA encoding human 2.3,7,8-tetrachlorodibenzo-p-dioxin (dioxin)-inducible cytosolic NQO1 [Jaiswal et al.	Dioxins	86-92	NAD(P)H quinone dehydrogenase 1	Homo sapiens	122-126
1899380-14	1991	The immunoreactive protein detected in human Hep-G2 cells was induced approximately fourfold by exposure of the cultures to dioxin, an increase commensurate with the increased in quinone oxidoreductase activity.	Dioxins	124-130	DNL-type zinc finger	Homo sapiens	45-48
1899380-14	1991	The immunoreactive protein detected in human Hep-G2 cells was induced approximately fourfold by exposure of the cultures to dioxin, an increase commensurate with the increased in quinone oxidoreductase activity.	Dioxins	124-130	crystallin zeta	Homo sapiens	179-201
1899380-15	1991	These studies suggest that the protein encoded by NQO1 cDNA is indeed similar, if not identical, to the dioxin-inducible protein band detected in human Hep-G2 cells.	Dioxins	104-110	NAD(P)H quinone dehydrogenase 1	Homo sapiens	50-54
1899380-15	1991	These studies suggest that the protein encoded by NQO1 cDNA is indeed similar, if not identical, to the dioxin-inducible protein band detected in human Hep-G2 cells.	Dioxins	104-110	DNL-type zinc finger	Homo sapiens	152-155
2156826-2	1990	The liganded receptor activates transcription by binding to a specific recognition motif within a dioxin-responsive enhancer upstream of the target CYP1A1 gene.	Dioxins	98-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	148-154
1846511-0	1991	Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer.	Dioxins	92-98	aryl hydrocarbon receptor	Rattus norvegicus	73-84
1846511-1	1991	Many of the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), a highly toxic environmental contaminant, are mediated by a soluble intracellular protein (the Ah receptor (AhR)).	Dioxins	73-79	aryl hydrocarbon receptor	Rattus norvegicus	191-202
1846511-1	1991	Many of the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), a highly toxic environmental contaminant, are mediated by a soluble intracellular protein (the Ah receptor (AhR)).	Dioxins	73-79	aryl hydrocarbon receptor	Rattus norvegicus	204-207
1846511-2	1991	Following a poorly defined process of transformation, during which the TCDD:AhR complex acquires the ability to bind to DNA with high affinity, TCDD:AhR complexes activate gene transcription by binding to dioxin responsive enhancers (DREs) adjacent to the responsive gene.	Dioxins	205-211	aryl hydrocarbon receptor	Rattus norvegicus	76-79
1846511-2	1991	Following a poorly defined process of transformation, during which the TCDD:AhR complex acquires the ability to bind to DNA with high affinity, TCDD:AhR complexes activate gene transcription by binding to dioxin responsive enhancers (DREs) adjacent to the responsive gene.	Dioxins	205-211	aryl hydrocarbon receptor	Rattus norvegicus	149-152
1846511-3	1991	Here we have utilized gel retardation analysis to study the interaction of rat hepatic cytosolic TCDD:AhR complexes, transformed in vitro, with dioxin responsive enhancer DNA.	Dioxins	144-150	aryl hydrocarbon receptor	Rattus norvegicus	102-105
1691923-3	1990	We have previously described a complementary DNA that encodes a dioxin-inducible cytosolic form of human NAD(P)H:quinone oxidoreductase (NQO1).	Dioxins	64-70	crystallin zeta	Homo sapiens	113-135
1691923-3	1990	We have previously described a complementary DNA that encodes a dioxin-inducible cytosolic form of human NAD(P)H:quinone oxidoreductase (NQO1).	Dioxins	64-70	NAD(P)H quinone dehydrogenase 1	Homo sapiens	137-141
2157617-1	1990	The biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), a potent environmental contaminant, are mediated by a soluble intracellular protein, the aromatic hydrocarbon (Ah) receptor (AhR).	Dioxins	55-61	aryl hydrocarbon receptor	Homo sapiens	167-201
2157617-1	1990	The biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), a potent environmental contaminant, are mediated by a soluble intracellular protein, the aromatic hydrocarbon (Ah) receptor (AhR).	Dioxins	55-61	aryl hydrocarbon receptor	Homo sapiens	203-206
2157617-2	1990	TCDD:AhR complexes activate gene transcription by binding to specific DNA sequences termed dioxin-responsive elements adjacent to TCDD-responsive genes.	Dioxins	91-97	aryl hydrocarbon receptor	Homo sapiens	5-8
33763068-1	2021	Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.	Dioxins	118-125	aryl hydrocarbon receptor	Homo sapiens	18-43
2161840-1	1990	The dioxin-responsive enhancer upstream of the CYP1A1 gene contains four copies of the recognition motif for the liganded Ah receptor.	Dioxins	4-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53
2161840-1	1990	The dioxin-responsive enhancer upstream of the CYP1A1 gene contains four copies of the recognition motif for the liganded Ah receptor.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	122-133
2161840-3	1990	In the context of the dioxin-responsive enhancer, a GC box, representing the DNA binding site for Sp1 (or a related transcription factor), has no detectable intrinsic activity but enhances gene expression when linked to a recognition motif for the liganded Ah receptor, thereby producing a synergistic effect on enhancer function.	Dioxins	22-28	aryl hydrocarbon receptor	Homo sapiens	257-268
2155580-1	1990	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) produces many of its biological effects by binding to a soluble, intracellular protein (the Ah receptor (AhR].	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	143-154
2155580-1	1990	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) produces many of its biological effects by binding to a soluble, intracellular protein (the Ah receptor (AhR].	Dioxins	29-35	aryl-hydrocarbon receptor	Mus musculus	156-159
33763068-1	2021	Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.	Dioxins	118-125	aryl hydrocarbon receptor repressor	Homo sapiens	45-48
1314949-0	1992	Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.	Dioxins	38-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	68-74
34848246-2	2022	We previously described the sequence of events following exposure of male rats to a dioxin-like polychlorinated biphenyl (PCB) congener, 3,3",4,4",5-pentachlorobiphenyl (PCB126), that binds avidly to the AhR and causes various types of toxicity including metabolic syndrome, fatty liver, and disruption of energy homeostasis.	Dioxins	84-90	aryl hydrocarbon receptor	Rattus norvegicus	204-207
34746229-1	2021	The aryl hydrocarbon receptor (AhR) is an environmentally responsive ligand-activated transcription factor, identified in the "70s for its toxic responses to halogenated polycyclic aromatic hydrocarbons, such as dioxin.	Dioxins	212-218	aryl hydrocarbon receptor	Homo sapiens	4-29
34991250-0	2022	Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.	Dioxins	47-53	aldo-keto reductase family 1 member C3	Homo sapiens	72-78
34991250-0	2022	Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.	Dioxins	47-53	epidermal growth factor receptor	Homo sapiens	91-95
34991250-0	2022	Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.	Dioxins	47-53	aryl hydrocarbon receptor	Homo sapiens	150-153
34991250-1	2022	Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	218-243
34991250-1	2022	Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses.	Dioxins	41-47	aryl hydrocarbon receptor	Homo sapiens	245-248
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Dioxins	39-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-111
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Dioxins	39-45	epidermal growth factor receptor	Homo sapiens	140-144
34559251-1	2021	Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of various physiologic AHR functions.	Dioxins	68-74	aryl hydrocarbon receptor	Homo sapiens	0-25
34747641-0	2021	Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure.	Dioxins	99-105	aryl hydrocarbon receptor	Rattus norvegicus	47-72
34747641-11	2021	DISCUSSION: We identified an AHR regulatory pathway in rats activated by dioxin affecting uterine and trophoblast cell dynamics and the formation of the hemochorial placenta.	Dioxins	73-79	aryl hydrocarbon receptor	Rattus norvegicus	29-32
34743025-0	2021	Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.	Dioxins	61-67	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	124-127
34743025-0	2021	Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.	Dioxins	61-67	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	132-135
34848742-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate toxic responses to dioxin.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	4-29
34848742-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate toxic responses to dioxin.	Dioxins	115-121	aryl-hydrocarbon receptor	Mus musculus	31-34
34746229-1	2021	The aryl hydrocarbon receptor (AhR) is an environmentally responsive ligand-activated transcription factor, identified in the "70s for its toxic responses to halogenated polycyclic aromatic hydrocarbons, such as dioxin.	Dioxins	212-218	aryl hydrocarbon receptor	Homo sapiens	31-34
34746229-4	2021	In this review, we explore the mutual regulation of AhR and miRNA over the last decade of studies since many miRNAs have dioxin response elements (DRE) in their 3" UTR, as well as AhR might contain binding sites of miRNAs.	Dioxins	121-127	aryl hydrocarbon receptor	Homo sapiens	52-55
35568185-4	2022	Although the dioxin-like PCB 3,3",4,4"-tetrachlorobiphenyl (CB77) is abundant in the environment and accumulates in organisms, information on CB77 metabolism by CYP1A1s is limited.	Dioxins	13-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	161-167
34289609-8	2021	Most of the peer-reviewed articles reported dioxins/furans or mercury within the Houston Ship Channel (HSC); there was limited reporting of other organics and metals.	Dioxins	44-51	inositol polyphosphate-5-phosphatase D	Homo sapiens	89-93
34343493-7	2021	Because AHR plays critical roles in cellular response to dioxin and UVR, we explored links between this SNP and AHR expression after both 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and ultraviolet B (UVB) exposure.	Dioxins	57-63	aryl hydrocarbon receptor	Homo sapiens	8-11
34142198-0	2021	Correction to: Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.	Dioxins	136-142	aryl-hydrocarbon receptor	Mus musculus	38-63
34256052-2	2021	The toxicity of dioxin-like PCBs, such as PCB126, is mediated via the aryl hydrocarbon receptor (AHR) in non-ovarian tissues.	Dioxins	16-22	aryl hydrocarbon receptor	Rattus norvegicus	70-95
34256052-2	2021	The toxicity of dioxin-like PCBs, such as PCB126, is mediated via the aryl hydrocarbon receptor (AHR) in non-ovarian tissues.	Dioxins	16-22	aryl hydrocarbon receptor	Rattus norvegicus	97-100
34573025-2	2021	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, induces toxic effects by mediating aryl hydrocarbon receptor (AHR).	Dioxins	59-65	aryl hydrocarbon receptor	Rattus norvegicus	102-127
34573025-2	2021	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, induces toxic effects by mediating aryl hydrocarbon receptor (AHR).	Dioxins	59-65	aryl hydrocarbon receptor	Rattus norvegicus	129-132
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	Dioxins	61-67	tumor protein p53	Homo sapiens	116-120
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	Dioxins	61-67	ribosomal protein S27a	Homo sapiens	122-128
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	Dioxins	61-67	ubiquitin C	Homo sapiens	134-137
34227765-9	2021	Carbon-based adsorbents of the Chinese stilbene polymer porous microspheres GDX series, GDX-101, GDX-102, GDX-103, GDX-105, and GDX-203, can facilitate thermal desorption below 270 C, which is the maximum tolerance temperature for series 1 and 2, thus providing evidence for the feasibility of using these adsorbents for the thermal adsorption/desorption of dioxins.	Dioxins	358-365	ubiquitin like 4A	Homo sapiens	76-79
34349414-1	2021	Background: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that acts as a binding site for toxic chemicals, particularly the dioxin group of chemicals.	Dioxins	153-159	aryl hydrocarbon receptor	Homo sapiens	12-37
34349414-1	2021	Background: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that acts as a binding site for toxic chemicals, particularly the dioxin group of chemicals.	Dioxins	153-159	aryl hydrocarbon receptor	Homo sapiens	39-42
35500338-4	2022	Less than 15% AhR potencies could be explained by detected dioxin-like PAHs.	Dioxins	59-65	aryl hydrocarbon receptor	Homo sapiens	14-17
35486615-9	2022	The presence of reads for biphenyl degradation, dioxin degradation, PAH degradation pathways can be further correlated with the presence of PCB and PAH as detected in the MGB-2 and MGB-3 samples.	Dioxins	48-54	secretoglobin family 2A member 1	Homo sapiens	171-176
35405238-1	2022	Bien Hoa airbase is the most dioxin-polluted hotspot in Vietnam.	Dioxins	29-35	matrilin 3	Homo sapiens	5-8
35338935-1	2022	The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	78-103
35338935-1	2022	The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway.	Dioxins	4-10	aryl hydrocarbon receptor	Homo sapiens	105-108
35617319-0	2022	The involvement of CYP1A2 in biodegradation of dioxins in pigs.	Dioxins	47-54	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	19-25
35617319-3	2022	TCDD binding to AhR results in the activation of cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP1B1) involved in dioxin biodegradation.	Dioxins	110-116	aryl hydrocarbon receptor	Sus scrofa	16-19
35617319-3	2022	TCDD binding to AhR results in the activation of cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP1B1) involved in dioxin biodegradation.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 1	Sus scrofa	74-80
35617319-3	2022	TCDD binding to AhR results in the activation of cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP1B1) involved in dioxin biodegradation.	Dioxins	110-116	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	82-88
35617319-5	2022	We investigated a molecular structure of CYP1A2 and the binding selectivity and affinity between the pig CYP1A2 and: 1/ DiCDD or TCDD (dioxins differing in toxicity and biodegradability) or 2/ their selected metabolites.	Dioxins	135-142	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	105-111
35617319-8	2022	The calculated distances between the heme oxygen and the dioxin carbon nearest to the oxygen, reflecting the hydroxylating potential of CYP1A2, were higher than in other pCYP1 enzymes.	Dioxins	57-63	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	136-142
35617319-10	2022	However, the molecular dynamics simulations revealed that two access channels of CYP1A2 were closed upon binding the majority of the examined dioxins.	Dioxins	142-149	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	81-87
35404044-0	2022	Insight into the Transformation Behaviors of Dioxins from Sintering Flue Gas in the Cyclic Thermal Regeneration by the V2O5/AC Catalyst-sorbent.	Dioxins	45-52	gastrin	Homo sapiens	73-76
35404044-1	2022	Dioxins in the sintering flue gas are usually removed through integrated elimination technologies by carbonaceous catalysts.	Dioxins	0-7	gastrin	Homo sapiens	30-33
35367886-0	2022	Dioxin-like polychlorinated biphenyl 126 (PCB126) disrupts gut microbiota-host metabolic dysfunction in mice via aryl hydrocarbon receptor activation.	Dioxins	0-6	aryl-hydrocarbon receptor	Mus musculus	113-138
35172007-0	2022	Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis.	Dioxins	0-6	Kruppel like factor 9	Homo sapiens	64-68
35448550-0	2022	Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity.	Dioxins	57-63	flavin containing monooxygenase 3	Mus musculus	0-33
35448550-0	2022	Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity.	Dioxins	57-63	flavin containing monooxygenase 3	Mus musculus	35-39
35038666-1	2022	The suitability of the AhR reporter gene bioassays to screen the presence of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in sewage sludge (SL) and related hydrochar (HC) was here investigated.	Dioxins	132-138	aryl hydrocarbon receptor	Homo sapiens	23-26
35618242-2	2022	We have previously demonstrated that exposure of human preadipocytes to the dioxin-like PCB126 disrupts adipogenesis via the aryl hydrocarbon receptor (AhR).	Dioxins	76-82	aryl hydrocarbon receptor	Homo sapiens	125-150
35618242-2	2022	We have previously demonstrated that exposure of human preadipocytes to the dioxin-like PCB126 disrupts adipogenesis via the aryl hydrocarbon receptor (AhR).	Dioxins	76-82	aryl hydrocarbon receptor	Homo sapiens	152-155
35183049-0	2022	Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor.	Dioxins	66-72	aryl hydrocarbon receptor	Homo sapiens	132-157
35183049-6	2022	These findings demonstrate that MWCNTs can impact the potential detoxification of dioxin-induced toxicity through modulating AhR signaling pathway.	Dioxins	82-88	aryl hydrocarbon receptor	Homo sapiens	125-128
35051068-8	2022	In conclusion, exposure of Greenlandic Inuit pregnant women to dioxin-like compounds through traditional marine food can adversely influence the fetal growth via induced AhR activity.	Dioxins	63-69	aryl hydrocarbon receptor	Homo sapiens	170-173
34995713-3	2022	Our previous study reported that the IL-24 gene is a dioxin response gene during 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) treatment.	Dioxins	53-59	interleukin 24	Homo sapiens	37-42
35051068-3	2022	The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid (AhR-TEQ (pg/g lipid)).	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	85-88
35051068-3	2022	The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid (AhR-TEQ (pg/g lipid)).	Dioxins	13-19	aryl hydrocarbon receptor	Homo sapiens	188-191
2553691-2	1989	The liganded receptor interacts with a specific DNA recognition motif located within a dioxin-responsive enhancer upstream of the CYP1A1 gene.	Dioxins	87-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-136
2553691-7	1989	These findings imply that DNA methylation can diminish the response to dioxin by impeding the Ah receptor-enhancer interaction.	Dioxins	71-77	aryl hydrocarbon receptor	Homo sapiens	94-105
2477842-1	1989	The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively.	Dioxins	4-10	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-47
2477842-1	1989	The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively.	Dioxins	4-10	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	67-73
2744682-0	1989	[Effects of dioxin congeners on aryl hydrocarbon hydroxylase activity].	Dioxins	12-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	32-60
2548080-0	1989	Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.	Dioxins	46-52	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-26
2693891-3	1989	Activation of CYP1A1 transcription requires the binding of TCDD to an intracellular protein, the Ah receptor, followed by the binding of the liganded receptor to a dioxin-responsive enhancer that is located upstream from the CYP1A1 gene.	Dioxins	164-170	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
2693891-3	1989	Activation of CYP1A1 transcription requires the binding of TCDD to an intracellular protein, the Ah receptor, followed by the binding of the liganded receptor to a dioxin-responsive enhancer that is located upstream from the CYP1A1 gene.	Dioxins	164-170	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	225-231
2789688-5	1989	Our results indicate that the Ah receptor-dependent, dioxin-responsive enhancer can activate transcription when in a regulatory context and in a chromosomal location different from those of the cytochrome P450iA1 gene.	Dioxins	53-59	aryl-hydrocarbon receptor	Mus musculus	30-41
2709162-5	1989	Analyses by various indices of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexa- to octachlorinated dioxins did not show deaths from these cancers to have been disproportionately distributed among the workers considered to have had the highest exposures.	Dioxins	108-115	hexosaminidase subunit alpha	Homo sapiens	83-87
2536161-2	1989	To define the recognition sequence of the dioxin receptor and its relationship with that of the glucocorticoid receptor, oligonucleotides derived from dioxin-responsive elements of the rat cytochrome P-450c gene were tested for their ability to form specific protein-DNA complexes in a gel retardation assay.	Dioxins	42-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	96-119
2848187-7	1988	The availability of this 125I-labeled dioxin congener also permitted the characterization of Ah receptor-ligand binding over a range of ligand and receptor concentrations not possible with currently available 3H-ligands.	Dioxins	38-44	aryl-hydrocarbon receptor	Mus musculus	93-104
2839475-5	1988	The concentration of dioxin required to give half-maximal induction of AHH activity was 16-fold greater in c35-1 than in Hepa-1.	Dioxins	21-27	aryl-hydrocarbon receptor	Mus musculus	71-74
2672473-0	1989	The control of cytochrome P-450 gene expression by dioxin.	Dioxins	51-57	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	15-31
2672473-3	1989	Studies of the mechanism by which TCDD (dioxin) activates CYP1A1 gene transcription demonstrate the usefulness of applying recombinant DNA and gene transfer methods to analyse these fundamental problems.	Dioxins	40-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
3327428-8	1987	Dioxin, vinyl chloride, and polyhalogenated biphenyls induce an incipient subclinical stage of chronic hepatic porphyria in persons with normal red cell uroporphyrinogen decarboxylase.	Dioxins	0-6	uroporphyrinogen decarboxylase	Homo sapiens	153-183
2828621-3	1988	Binding of dioxin to a soluble intracellular protein (dioxin or Ah receptor) appears to be the initial step in their mechanism of toxicity and a stacking interaction model has been proposed at the molecular level.	Dioxins	11-17	aryl hydrocarbon receptor	Homo sapiens	64-75
15092651-4	1988	The recent isomer-specific analyses suggest that the intrinsic toxicity of PCBs principally resulted from the coplanar PCB congeners which may impose a greater toxic threat than chlorinated dioxins and furans to humans and wildlife.	Dioxins	190-197	pyruvate carboxylase	Homo sapiens	75-78
2536161-3	1989	We found that a previously defined sequence motif that is similar to the glucocorticoid-responsive element and exhibits strong enhancer activity in response to dioxin receptor ligands bound a dioxin-inducible factor with high specificity but was not recognized by the DNA-binding domain of the glucocorticoid receptor.	Dioxins	160-166	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	294-317
3040289-4	1987	PSP was purified from the rat ventral prostate and labeled in vitro with 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (dioxin).	Dioxins	106-112	reactive intermediate imine deaminase A homolog	Rattus norvegicus	0-3
3040289-5	1987	Dioxin-labeled PSP was then incubated with rat liver cytosol in the presence or absence of a 200-fold excess of nonradioactive competitor, 2,3,7,8-tetrachlorodibenzofuran.	Dioxins	0-6	reactive intermediate imine deaminase A homolog	Rattus norvegicus	15-18
3040289-6	1987	After 2 h of incubation, a complete in vitro transfer of ligand from PSP to the rat hepatic dioxin receptor was observed, as assessed by velocity sedimentation analysis of specific dioxin binding.	Dioxins	92-98	reactive intermediate imine deaminase A homolog	Rattus norvegicus	69-72
3629609-1	1987	A set of 5 anti-dioxin monoclonal antibodies (mAbs), named DD-1, DD-3, DD-4, DD-5 and DD-6, have been isolated.	Dioxins	16-22	aldo-keto reductase family 1 member C1	Homo sapiens	59-69
3327428-9	1987	In contrast, exposure to dioxin on the part of persons with inherited uroporphyrinogen decarboxylase deficiency can cause latent chronic hepatic porphyria to develop into PCT.	Dioxins	25-31	uroporphyrinogen decarboxylase	Homo sapiens	70-100
3681487-1	1987	P(1)450 and P(3)450 are the two members of the dioxin-inducible P450 gene family, one of at least eight families in the entire P450 gene superfamily.	Dioxins	47-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-7
3681487-1	1987	P(1)450 and P(3)450 are the two members of the dioxin-inducible P450 gene family, one of at least eight families in the entire P450 gene superfamily.	Dioxins	47-53	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-19
3681487-1	1987	P(1)450 and P(3)450 are the two members of the dioxin-inducible P450 gene family, one of at least eight families in the entire P450 gene superfamily.	Dioxins	47-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	64-68
3681487-1	1987	P(1)450 and P(3)450 are the two members of the dioxin-inducible P450 gene family, one of at least eight families in the entire P450 gene superfamily.	Dioxins	47-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	127-131
3963817-5	1986	Cytochrome P-450, isozyme 4, was not detected in the pulmonary microsomal fraction from untreated or 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rabbits.	Dioxins	130-136	cytochrome P450 1A2	Oryctolagus cuniculus	0-27
3000715-0	1985	Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.	Dioxins	68-74	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
3838385-0	1985	Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.	Dioxins	6-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
6714509-0	1984	Development of chronic hepatic porphyria (porphyria cutanea tarda) with inherited uroporphyrinogen decarboxylase deficiency under exposure to dioxin.	Dioxins	142-148	uroporphyrinogen decarboxylase	Homo sapiens	82-112
6714509-1	1984	Exposure to dioxin triggered a clinically manifest chronic hepatic porphyria (porphyria cutanea tarda) in two patients (brother and sister) with hereditary uroporphyrinogen decarboxylase deficiency.	Dioxins	12-18	uroporphyrinogen decarboxylase	Homo sapiens	156-186
6714509-13	1984	We conclude that a unique acute exposure to dioxin can trigger the chronic hepatic porphyria disease process in persons with an underlying genetic abnormality of uroporphyrinogen decarboxylase.	Dioxins	44-50	uroporphyrinogen decarboxylase	Homo sapiens	162-192
6584878-7	1983	Similar changes in steroid delta 4-5 alpha-reduction and cytochrome P-450-dependent chemical oxidations have been observed in circumstances in which the mixed-function oxidase system in liver is induced by agents such as phenobarbital, hexachlorobenzene, dioxin, and polyhalogenated biphenyls.	Dioxins	255-261	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-73
6412692-4	1983	Simultaneous treatment of cultures with dioxin and phenobarbital produced a synergistic response in delta-aminolaevulinate synthase induction, uroporphyrinogen decarboxylase inhibition and porphyrin accumulation.	Dioxins	40-46	uroporphyrinogen decarboxylase	Homo sapiens	143-173
6412692-5	1983	These data suggest that an inhibitor of uroporphyrinogen decarboxylase may be generated in the liver from polychlorinated biphenyl compounds or dioxin by metabolic activation.	Dioxins	144-150	uroporphyrinogen decarboxylase	Homo sapiens	40-70
4043593-5	1985	The induction of AHH activity in primary cultures of adult rat hepatocytes may represent a useful bioassay for screening extracts of foodstuffs, biological fluids, or environmental samples for dioxin-like activity.	Dioxins	193-199	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	17-20
6092439-0	1984	Location of Ah receptor for dioxin.	Dioxins	28-34	aryl hydrocarbon receptor	Homo sapiens	12-23
729578-1	1978	In the liver of perinatal rats or mice, the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon hydroxylase to total cytochrome P-450 content decreases, whereas the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced acetanilide 4-hydroxylase to total cytochrome P-450 content increases, between 18 or 19 days and 22 days following conception.	Dioxins	82-88	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	135-151
729578-1	1978	In the liver of perinatal rats or mice, the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon hydroxylase to total cytochrome P-450 content decreases, whereas the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced acetanilide 4-hydroxylase to total cytochrome P-450 content increases, between 18 or 19 days and 22 days following conception.	Dioxins	82-88	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	271-287