PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16302802-0	2005	Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.	hydroxyethylene dipeptide	23-48	beta-secretase 1	Homo sapiens	134-138
12444650-6	2002	The approach is demonstrated by the synthesis of a series of six hydroxyethylene dipeptide isosteres, including the diamino alcohol core of potent HIV-protease inhibitor ritonavir 18 and its C-2 epimer 11a.	hydroxyethylene dipeptide	65-90	complement C2	Homo sapiens	191-194
2404121-2	1990	The synthesis of a series of renin inhibitors in which the P2 and P3 amino acids are replaced with the hydroxyethylene dipeptide isostere is reported.	hydroxyethylene dipeptide	103-128	renin	Homo sapiens	29-34
1588555-3	1992	Introduction of basic substituents into modified hydroxyethylene dipeptide isosteres gave inhibitors with improved solubility as well as improved potency against human plasma renin.	hydroxyethylene dipeptide	49-74	renin	Homo sapiens	175-180