PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28663087-3	2017	Inspired by the CD44-mediated tumor targeting ability of hyaluronate (HA), we developed HA-coated PMN-NCs (HA-NCs) via electrostatic layer-by-layer assembly.	hyaluronate	57-68	CD44 molecule (Indian blood group)	Homo sapiens	16-20
28477470-5	2017	Through the specific binding of hyaluronate on hollow spheres with CD44 receptors overexpressed on cancer cells, the drug-loaded hollow spheres can be specifically delivered to target cancer cells.	hyaluronate	32-43	CD44 molecule (Indian blood group)	Homo sapiens	67-71
28274796-4	2017	In this study, the vascular endothelial growth factor (VEGF)-specific siRNAs were first electrostatically condensed into a ternary nanocomplex composed of polycation and hyaluronate, which was subsequently enveloped by LipoMET through membrane fusion.	hyaluronate	170-181	vascular endothelial growth factor A	Homo sapiens	19-53
28274796-4	2017	In this study, the vascular endothelial growth factor (VEGF)-specific siRNAs were first electrostatically condensed into a ternary nanocomplex composed of polycation and hyaluronate, which was subsequently enveloped by LipoMET through membrane fusion.	hyaluronate	170-181	vascular endothelial growth factor A	Homo sapiens	55-59
22824530-0	2012	Flt1 peptide-hyaluronate conjugate micelle-like nanoparticles encapsulating genistein for the treatment of ocular neovascularization.	hyaluronate	13-24	Fms related receptor tyrosine kinase 1	Rattus norvegicus	0-4
27933820-2	2016	Here, hyaluronate-gold nanorod/death receptor 5 antibody (HA-AuNR/DR5 Ab) complex was developed for transdermal theranosis of skin cancer.	hyaluronate	6-17	TNF receptor superfamily member 10b	Homo sapiens	31-47
27933820-2	2016	Here, hyaluronate-gold nanorod/death receptor 5 antibody (HA-AuNR/DR5 Ab) complex was developed for transdermal theranosis of skin cancer.	hyaluronate	6-17	TNF receptor superfamily member 10b	Homo sapiens	66-69
26066970-3	2015	Binding of hyaluronate to CD44 HABD induces an allosteric conformational change, which results in CD44 shedding.	hyaluronate	11-22	CD44 molecule (Indian blood group)	Homo sapiens	26-30
26066970-3	2015	Binding of hyaluronate to CD44 HABD induces an allosteric conformational change, which results in CD44 shedding.	hyaluronate	11-22	CD44 molecule (Indian blood group)	Homo sapiens	98-102
26066970-4	2015	A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding.	hyaluronate	125-136	CD44 molecule (Indian blood group)	Homo sapiens	40-44
26066970-4	2015	A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding.	hyaluronate	125-136	CD44 molecule (Indian blood group)	Homo sapiens	148-152
26066970-4	2015	A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding.	hyaluronate	125-136	CD44 molecule (Indian blood group)	Homo sapiens	148-152
26066970-9	2015	The MEM-85 epitope is situated in the C-terminal part of CD44 HABD, rather than the hyaluronate-binding groove, and the binding of MEM-85 induces a structural reorganization similar to that induced by hyaluronate.	hyaluronate	201-212	CD44 molecule (Indian blood group)	Homo sapiens	57-61
24573205-5	2014	The selective localization of MCT1 and LYVE-1 suggests a high level of activity for lymphoid reticular cells in the uptake of carboxylate-modified and hyaluronate waste substances circulating in the body.	hyaluronate	151-162	modifier of curly tail 1	Mus musculus	30-34
24573205-5	2014	The selective localization of MCT1 and LYVE-1 suggests a high level of activity for lymphoid reticular cells in the uptake of carboxylate-modified and hyaluronate waste substances circulating in the body.	hyaluronate	151-162	lymphatic vessel endothelial hyaluronan receptor 1	Mus musculus	39-45
23658915-0	2013	Mechanisms underlying modulation of the pharmacological properties of pegylated erythropoietin by pegylated hyaluronate-endo-beta-N-acetylhexosaminidase.	hyaluronate	108-119	erythropoietin	Homo sapiens	80-94
23658915-0	2013	Mechanisms underlying modulation of the pharmacological properties of pegylated erythropoietin by pegylated hyaluronate-endo-beta-N-acetylhexosaminidase.	hyaluronate	108-119	O-GlcNAcase	Homo sapiens	125-152
24390942-1	2013	One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate.	hyaluronate	113-124	versican	Homo sapiens	79-87
23330143-0	2012	Effect of hyaluronate-endo-beta-N-acetylhexosaminidase pegylated by electron beam synthesis nanotechnology on the formation of hematological shifts in chronic hepatitis.	hyaluronate	10-21	O-GlcNAcase	Homo sapiens	27-54
28224886-3	2017	Hyaluronate, a main component of glycosaminoglycans, provides CD44-specific interactions with chondrocytes but typically requires chemical cross-linking agents to fabricate hydrogels, which may cause unexpected side effects in the body.	hyaluronate	0-11	CD44 antigen	Mus musculus	62-66
27775884-3	2016	Here, to improve the transdermal delivery efficiency, EGF was conjugated to hyaluronate (HA), which was formulated into a patch-type film for skin wound healing.	hyaluronate	76-87	epidermal growth factor	Homo sapiens	54-57
26228271-0	2015	Two-photon microscopy of a Flt1 peptide-hyaluronate conjugate.	hyaluronate	40-51	fms related receptor tyrosine kinase 1	Homo sapiens	27-31
26228271-1	2015	AIM: Two-photon microscopy was performed to visualize ocular distribution of Flt1 peptide-hyaluronate (HA) conjugate micelles for eye drop treatment of corneal neovascularization.	hyaluronate	90-101	fms related receptor tyrosine kinase 1	Homo sapiens	77-81
23397370-0	2013	Triiodothyronine (T3) inhibits hyaluronate synthesis in a human dermal equivalent by downregulation of HAS2.	hyaluronate	31-42	hyaluronan synthase 2	Homo sapiens	103-107
23397370-10	2013	The results from these experiments suggest that downregulation of HAS2 may be responsible for inhibition of hyaluronate synthesis in the self-assembled 2-nM T3 human dermal matrix.	hyaluronate	108-119	hyaluronan synthase 2	Homo sapiens	66-70
22824530-2	2012	In this work, Flt1 peptide-hyaluronate (HA) conjugates were successfully synthesized and the resulting micelle-like nanoparticles were exploited to encapsulate genistein, an inhibitor of tyrosine-specific protein kinases, for the treatment of ocular neovascularization.	hyaluronate	27-38	Fms related receptor tyrosine kinase 1	Rattus norvegicus	14-18
21179550-0	2010	Synergistic effect of hyaluronate fragments in retinaldehyde-induced skin hyperplasia which is a Cd44-dependent phenomenon.	hyaluronate	22-33	CD44 antigen	Mus musculus	97-101
22808503-0	2012	Hypoglycemic effects of hyaluronate-endo-beta-N-acetylhexosaminidase immobilized by electron beam synthesis nanotechnology.	hyaluronate	24-35	O-GlcNAcase	Homo sapiens	41-68
22808503-1	2012	Hypoglycemic effect of hyaluronate-endo-beta-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulin-dependent and insulin-independent diabetes mellitus.	hyaluronate	23-34	O-GlcNAcase	Homo sapiens	40-67
22808503-1	2012	Hypoglycemic effect of hyaluronate-endo-beta-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulin-dependent and insulin-independent diabetes mellitus.	hyaluronate	23-34	insulin	Homo sapiens	161-168
21788071-3	2011	As a model theranostic system on demand, cucurbit[6]uril-conjugated hyaluronate (CB[6]-HA) was synthesized and decorated with FITC-spermidine (spmd) and/or formyl peptide receptor like 1 (FPRL1) specific peptide-spmd by simple mixing in aqueous solution.	hyaluronate	68-79	formyl peptide receptor 2	Homo sapiens	156-186
21788071-3	2011	As a model theranostic system on demand, cucurbit[6]uril-conjugated hyaluronate (CB[6]-HA) was synthesized and decorated with FITC-spermidine (spmd) and/or formyl peptide receptor like 1 (FPRL1) specific peptide-spmd by simple mixing in aqueous solution.	hyaluronate	68-79	formyl peptide receptor 2	Homo sapiens	188-193
21277020-0	2011	Anti-Flt1 peptide - hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy.	hyaluronate	20-31	Fms related receptor tyrosine kinase 1	Rattus norvegicus	5-9
20035907-7	2010	In the present study the ratio of expression of TIMP1 to MMP1 was lower in foreskin fibroblast cells that were cultured on a hyaluronate-collagen composite nanofibrous matrix than in those cultured on an exclusively collagen nanofibrous matrix.	hyaluronate	125-136	TIMP metallopeptidase inhibitor 1	Homo sapiens	48-53
20035907-7	2010	In the present study the ratio of expression of TIMP1 to MMP1 was lower in foreskin fibroblast cells that were cultured on a hyaluronate-collagen composite nanofibrous matrix than in those cultured on an exclusively collagen nanofibrous matrix.	hyaluronate	125-136	matrix metallopeptidase 1	Homo sapiens	57-61
18214641-8	2008	The large amount of collagen fibrils and hyaluronate molecules which surround the cells scattered in WJ may prevent the access of extracting solution to TGF-beta causing a low extractability of this factor.	hyaluronate	41-52	transforming growth factor beta 1	Homo sapiens	153-161
19447215-0	2009	Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production.	hyaluronate	67-78	matrix metallopeptidase 1	Homo sapiens	93-96
19647313-0	2009	Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization.	hyaluronate	77-88	Fms related receptor tyrosine kinase 1	Rattus norvegicus	64-68
19647313-2	2009	In this work, a protocol to synthesize anti-Flt1 peptide-hyaluronate (HA) conjugate was successfully developed for the treatment of corneal neovascularization.	hyaluronate	57-68	Fms related receptor tyrosine kinase 1	Rattus norvegicus	44-48
18690645-3	2008	The CD44 variants modified by the sialyl Lewis a and sialyl Lewis x glycotopes are expected to have dual functions, serving as ligands for vascular selectins, and simultaneously having binding activity to vascular bed hyaluronate, and are expected to figure heavily in cancer metastasis.	hyaluronate	218-229	CD44 molecule (Indian blood group)	Homo sapiens	4-8
18654930-7	2008	Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7.	hyaluronate	91-102	solute carrier family 9 member A7	Homo sapiens	10-14
18654930-7	2008	Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7.	hyaluronate	91-102	CD44 molecule (Indian blood group)	Homo sapiens	44-48
18654930-7	2008	Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7.	hyaluronate	91-102	solute carrier family 9 member A7	Homo sapiens	156-160
17565391-8	2007	We propose that ground substance composed mainly of collagen fibrils and hyaluronate molecules, which surrounds the cells of Wharton"s jelly, prevents the access of the extracting solution to aFGF and bFGF.	hyaluronate	73-84	fibroblast growth factor 1	Homo sapiens	192-196
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	platelet and endothelial cell adhesion molecule 1	Homo sapiens	78-82
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	CD38 molecule	Homo sapiens	88-92
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	platelet and endothelial cell adhesion molecule 1	Homo sapiens	177-181
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	platelet and endothelial cell adhesion molecule 1	Homo sapiens	177-181
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	platelet and endothelial cell adhesion molecule 1	Homo sapiens	177-181
17875702-2	2007	The AML leukemic cells express platelet/endothelial cell adhesion molecule-1 (CD31) and CD38, two adhesion molecules that could interact with microenvironmental elements, i.e., CD31 on the surface of marrow endothelial cells (CD31/CD31 and CD38/CD31 interactions) and hyaluronate (CD38/hyaluronate interactions).	hyaluronate	268-279	platelet and endothelial cell adhesion molecule 1	Homo sapiens	177-181
17565391-8	2007	We propose that ground substance composed mainly of collagen fibrils and hyaluronate molecules, which surrounds the cells of Wharton"s jelly, prevents the access of the extracting solution to aFGF and bFGF.	hyaluronate	73-84	fibroblast growth factor 2	Homo sapiens	201-205
17177600-0	2006	Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism.	hyaluronate	0-11	CD44 molecule (Indian blood group)	Homo sapiens	48-52
16724877-4	2006	UVA (10 J/cm(2)) or UVB (1 J/cm(2)) irradiation significantly decreased the expression of CD44 and hyaluronate in the epidermis of hairless mice after 2 h. Expression of both epidermal CD44 and hyaluronate was reconstituted within 24 h. Topical application of retinaldehyde for 3 days prior to UVA or UVB irradiation prevented the decrease of CD44 and hyaluronate expression.	hyaluronate	194-205	CD44 antigen	Mus musculus	90-94
12379212-3	2002	An NF-kappaB decoy (NF-kappaB31: 5(")-TGGGGACTTTCCAGTTTCTGGAAAGTCCCCA-3), which contains a consensus sequence for NF-kappaB, was complexed to PLL-g-HA [hyaluronate-grafted poly(L-lysine) copolymer] that permits transfer of exogenous DNA selectively to the SEC.	hyaluronate	152-163	nuclear factor kappa B subunit 1	Homo sapiens	3-12
12949055-8	2003	OPN increased HepG2 in vitro adhesion to hyaluronate (HA); excess soluble HA extinguished OPN-mediated HepG2 adhesion, indicating CD44 dependence.	hyaluronate	41-52	secreted phosphoprotein 1	Homo sapiens	0-3
16713618-2	2006	One molecule playing a major role in these processes is the CD44 surface receptor, which is expressed in a wide range of cells including many cells of the hemopoietic system, where it mediates the interaction with its major ligand, hyaluronate.	hyaluronate	232-243	CD44 molecule (Indian blood group)	Homo sapiens	60-64
15844216-2	2005	In epithelia, among other functions, the adhesion protein CD44 promotes the contact to components of the extracellular matrix like hyaluronate.	hyaluronate	131-142	CD44 molecule (Indian blood group)	Homo sapiens	58-62
15383690-0	2004	Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.	hyaluronate	0-11	interleukin 1 beta	Homo sapiens	25-42
15383690-0	2004	Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.	hyaluronate	0-11	matrix metallopeptidase 1	Homo sapiens	65-97
15383690-0	2004	Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.	hyaluronate	0-11	matrix metallopeptidase 3	Homo sapiens	102-107
15124536-6	2004	Effect of CD44-specific antisense oligonucleotide on adhesion of trabecular meshwork cells to hyaluronate was determined by MTT assay.	hyaluronate	94-105	CD44 molecule (Indian blood group)	Homo sapiens	10-14
15124536-10	2004	Adhesion of trabecular meshwork cells to hyaluronate was inhibited by CD44-specific antisense oligonucleotide.	hyaluronate	41-52	CD44 molecule (Indian blood group)	Homo sapiens	70-74
12379212-3	2002	An NF-kappaB decoy (NF-kappaB31: 5(")-TGGGGACTTTCCAGTTTCTGGAAAGTCCCCA-3), which contains a consensus sequence for NF-kappaB, was complexed to PLL-g-HA [hyaluronate-grafted poly(L-lysine) copolymer] that permits transfer of exogenous DNA selectively to the SEC.	hyaluronate	152-163	nuclear factor kappa B subunit 1	Homo sapiens	20-29
12362105-5	2002	RESULTS: In the first group, the prothrombin index was predicted accurately by serum hyaluronate (R(2)= 0.67 at the first step by multiple regression).	hyaluronate	85-96	coagulation factor II, thrombin	Homo sapiens	33-44
12124794-0	2002	Hyaluronate-heparin conjugate gels for the delivery of basic fibroblast growth factor (FGF-2).	hyaluronate	0-11	fibroblast growth factor 2	Homo sapiens	87-92
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	hyaluronate	153-164	fibroblast growth factor 2	Homo sapiens	35-61
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	hyaluronate	153-164	fibroblast growth factor 2	Homo sapiens	63-68
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	hyaluronate	153-164	fibroblast growth factor 2	Homo sapiens	63-66
11853557-0	2002	Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.	hyaluronate	0-11	interleukin 1 beta	Bos taurus	99-116
12183839-4	2002	Although MA-8 and another anti-CD44 antibody, IM7.8.1, blocked adhesion of hematopoietic cells to hyaluronate, adhesion to BM stroma was notably increased by these mAb, suggesting minor roles for CD44/hyaluronate interaction and the triggering of additional adhesion pathways upon CD44 engagement.	hyaluronate	98-109	CD44 antigen	Mus musculus	31-35
11896162-12	2002	In rat brain, approximately half of the versican is bound to hyaluronate.	hyaluronate	61-72	versican	Rattus norvegicus	40-48
11850556-5	2002	Children with asthma or wheeze and those with serum IgE concentrations of 250 IU/ml or above showed differences in hyaluronate concentrations that related to the degree of air pollution in the communities.	hyaluronate	115-126	immunoglobulin heavy constant epsilon	Homo sapiens	52-55
11850556-6	2002	In children with higher serum IgE concentrations, the hyaluronate concentrations among subjects exposed to ETS were significantly higher than among those without exposure to ETS.	hyaluronate	54-65	immunoglobulin heavy constant epsilon	Homo sapiens	30-33
11464867-2	2001	CD44H is the major receptor for hyaluronate, and most if not all CD44H known functions are attributed to its ability to recognize hyaluronate.	hyaluronate	32-43	CD44 molecule (Indian blood group)	Homo sapiens	0-4
11320076-5	2001	CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion.	hyaluronate	36-47	CD44 molecule (Indian blood group)	Homo sapiens	0-4
11320076-5	2001	CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion.	hyaluronate	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11320076-5	2001	CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion.	hyaluronate	36-47	CD44 molecule (Indian blood group)	Homo sapiens	110-114
11316791-3	2001	At high cell density, merlin becomes hypo-phosphorylated and inhibits cell growth in response to hyaluronate (HA), a mucopolysaccharide that surrounds cells.	hyaluronate	97-108	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	22-28
11463496-4	2001	Hyaluronate (HA), a ligand of CD44, inhibited a number of lung metastases in a dose-dependent manner (0.5% HA, 3.0+/-1.1; 0.005% HA, 5.1+/-1.5; without HA, 8.6+/-1.7; N=10 for each; P<0.05, each group with HA versus the group without HA).	hyaluronate	0-11	CD44 antigen	Mus musculus	30-34
11464867-5	2001	PROCEDURE: In the present study we have compared the glycosylated structure of CD44 expressed by NMYC amplified vs. nonamplified cell lines in relation to their adhesive properties for hyaluronate.	hyaluronate	185-196	CD44 molecule (Indian blood group)	Homo sapiens	79-83
11464867-5	2001	PROCEDURE: In the present study we have compared the glycosylated structure of CD44 expressed by NMYC amplified vs. nonamplified cell lines in relation to their adhesive properties for hyaluronate.	hyaluronate	185-196	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	97-101
11464867-7	2001	RESULTS AND CONCLUSIONS: Our results indicate that increased sialylation, defective N-linked glycosylation, and substitution of the CD44 glycoprotein with keratan sulfate glycosaminoglycan might include modifications observed on neuroblastoma cells that could account for the inability of the receptor to bind hyaluronate.	hyaluronate	310-321	CD44 molecule (Indian blood group)	Homo sapiens	132-136
11426626-1	2000	Human CD34+ hematopoietic progenitor cells (HPCs) express CD44 and can directly adhere to hyaluronate (HA) via CD44.	hyaluronate	90-101	CD34 molecule	Homo sapiens	6-10
11149422-3	2001	In vitro studies showed a significantly reduced ability of the stable antisense transfectants (LS174TAS1 and LS174TAS2) to bind hyaluronate and osteopontin, ligands for CD44.	hyaluronate	128-139	CD44 molecule (Indian blood group)	Homo sapiens	169-173
11149422-8	2001	In vitro adhesion assays between the transfectants or controls and human peritoneal mesothelial cells revealed that the binding of LS174T cells to mesothelial cells was partly mediated by CD44-hyaluronate interaction.	hyaluronate	193-204	CD44 molecule (Indian blood group)	Homo sapiens	188-192
11149422-9	2001	These data suggest that CD44-hyaluronate interaction plays a crucial role in peritoneal dissemination in colorectal carcinoma.	hyaluronate	29-40	CD44 molecule (Indian blood group)	Homo sapiens	24-28
11121141-0	2000	Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus.	hyaluronate	76-87	CD44 molecule (Indian blood group)	Homo sapiens	22-26
11121141-3	2000	In a recent study we have observed a massive dermal accumulation of hyaluronate as a result of the in vivo selective suppression of CD44 in keratinocytes in mice expressing a keratin 5 promoter-driven CD44 anti-sense transgene.	hyaluronate	68-79	CD44 antigen	Mus musculus	132-136
11121141-3	2000	In a recent study we have observed a massive dermal accumulation of hyaluronate as a result of the in vivo selective suppression of CD44 in keratinocytes in mice expressing a keratin 5 promoter-driven CD44 anti-sense transgene.	hyaluronate	68-79	CD44 antigen	Mus musculus	201-205
11121141-5	2000	In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate.	hyaluronate	39-50	CD44 molecule (Indian blood group)	Homo sapiens	169-173
11121141-5	2000	In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate.	hyaluronate	230-241	CD44 molecule (Indian blood group)	Homo sapiens	169-173
11121141-8	2000	These results suggest that a decrease in CD44 in the keratinocytes may be correlated with an abnormal dermal accumulation of hyaluronate in the lesions of lichen sclerosus et atrophicus, and may play a pathogenetic role in this disease.	hyaluronate	125-136	CD44 molecule (Indian blood group)	Homo sapiens	41-45
10896935-5	2000	The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate.	hyaluronate	123-134	CD44 antigen	Mus musculus	38-42
10896935-5	2000	The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate.	hyaluronate	123-134	Harvey rat sarcoma virus oncogene	Mus musculus	71-77
11003990-5	2000	The binding capacity of NK cells to a CD44 ligand, hyaluronate, was reduced by the stimulation with norepinephrine (P < 0.01).	hyaluronate	51-62	CD44 molecule (Indian blood group)	Homo sapiens	38-42
11426626-1	2000	Human CD34+ hematopoietic progenitor cells (HPCs) express CD44 and can directly adhere to hyaluronate (HA) via CD44.	hyaluronate	90-101	CD44 molecule (Indian blood group)	Homo sapiens	111-115
10962384-8	2000	Finally, a significant negative correlation was found between hyaluronate and the prothrombin index (r =- 0.86, P <0.0001).	hyaluronate	62-73	coagulation factor II, thrombin	Homo sapiens	82-93
10699925-7	2000	HT29 transfectants expressing this mutant CD44s demonstrate an 84% reduction in growth of liver metastases, despite minimal binding to hyaluronate by the mutant CD44s.	hyaluronate	135-146	CD44 molecule (Indian blood group)	Homo sapiens	42-46
10880107-7	2000	CD44, a cell-surface glycoprotein that binds hyaluronate, was also expressed by these cells.	hyaluronate	45-56	CD44 antigen	Oryctolagus cuniculus	0-4
10857758-5	2000	Both hyaluronate, which binds CD44, and rat IgGs are also able to inhibit the induction of NO synthesis by the inflammatory mediators.	hyaluronate	5-16	CD44 antigen	Mus musculus	30-34
10594733-9	1999	We observed an increase in the migration ability of hyaluronate cDNA (HAS1 or HAS2)-transfected cells compared with control cells on glass plates covered with colloidal gold particles.	hyaluronate	52-63	hyaluronan synthase 1	Homo sapiens	70-74
10594733-9	1999	We observed an increase in the migration ability of hyaluronate cDNA (HAS1 or HAS2)-transfected cells compared with control cells on glass plates covered with colloidal gold particles.	hyaluronate	52-63	hyaluronan synthase 2	Homo sapiens	78-82
10232693-1	1999	Low molecular weight hyaluronate (LMW-HA) blocks interactions between T lymphocyte CD44 and hyaluronate (HA), a heteropolysaccharide that is expressed on the surface of endothelial cells and ubiquitously in the extracellular matrix.	hyaluronate	21-32	CD44 molecule (Indian blood group)	Rattus norvegicus	83-87
10419885-0	1999	Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages.	hyaluronate	0-11	interleukin 1 beta	Mus musculus	83-100
10419885-0	1999	Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages.	hyaluronate	0-11	interleukin 6	Mus musculus	105-118
10415022-5	1999	In contrast, the so-called blocking anti-CD44 mAbs (epitope group f) that can abrogate the binding of hyaluronate (HA) failed to induce apoptosis even after further cross-linking with the secondary Ab, indicating that a mere mAb-induced oligomerization of the chimeric proteins is insufficient for signal generation.	hyaluronate	102-113	CD44 molecule (Indian blood group)	Homo sapiens	41-45
10529137-0	1999	Effects of hyaluronate on CD44 expression of infiltrating cells in exudate of rat air pouch, induced by sensitization with lipopolysaccharide.	hyaluronate	11-22	CD44 molecule (Indian blood group)	Rattus norvegicus	26-30
10529137-1	1999	OBJECTIVE: To investigate the effects of hyaluronate (HA) on CD44 expression of infiltrating cells in vivo.	hyaluronate	41-52	CD44 molecule (Indian blood group)	Rattus norvegicus	61-65
10406188-9	1999	In the patients with chronic viral liver disease, serum MMP-2 concentration showed the best correlation with the degree of liver fibrosis and with serum hyaluronate level.	hyaluronate	153-164	matrix metallopeptidase 2	Homo sapiens	56-61
10232693-1	1999	Low molecular weight hyaluronate (LMW-HA) blocks interactions between T lymphocyte CD44 and hyaluronate (HA), a heteropolysaccharide that is expressed on the surface of endothelial cells and ubiquitously in the extracellular matrix.	hyaluronate	92-103	CD44 molecule (Indian blood group)	Rattus norvegicus	83-87
10199742-2	1999	METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection.	hyaluronate	65-76	CD44 molecule (Indian blood group)	Homo sapiens	59-63
10199742-2	1999	METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection.	hyaluronate	65-76	CD44 molecule (Indian blood group)	Homo sapiens	112-116
9614382-0	1998	Hyaluronate binding assay study of transfected CD44 V4-V7 isoforms into the human gastric carcinoma cell line SC-M1.	hyaluronate	0-11	CD44 molecule (Indian blood group)	Homo sapiens	47-51
10050880-9	1999	These results suggest that CD44 cleavage plays a critical role in an efficient cell-detachment from a hyaluronate substrate during the cell migration and consequently promotes CD44-mediated cancer cell migration.	hyaluronate	102-113	CD44 molecule (Indian blood group)	Homo sapiens	27-31
10050880-9	1999	These results suggest that CD44 cleavage plays a critical role in an efficient cell-detachment from a hyaluronate substrate during the cell migration and consequently promotes CD44-mediated cancer cell migration.	hyaluronate	102-113	CD44 molecule (Indian blood group)	Homo sapiens	176-180
10439835-5	1999	Most studies have reported that the regulation of CD44 binding to hyaluronate results from glycosylation of variably spliced exons.	hyaluronate	66-77	CD44 molecule (Indian blood group)	Homo sapiens	50-54
10439835-6	1999	Direct hyaluronate binding studies of CD44 V4-V7 isoforms transfected into the human gastric carcinoma cell line, SC-M1, have indicated that the V4-V7 isoforms themselves, in addition to glycosylation, can alter hyaluronate binding.	hyaluronate	7-18	CD44 molecule (Indian blood group)	Homo sapiens	38-42
9622073-4	1998	In this study, an investigation was made to resolve whether the ability of the standard CD44 isoform to suppress metastasis of the AT3.1 prostate cancer cells critically requires enhanced hyaluronate binding.	hyaluronate	188-199	CD44 molecule (Indian blood group)	Rattus norvegicus	88-92
9622073-8	1998	Expression of the wild-type standard CD44 isoform increased the hyaluronate binding of prostate cancer cells and suppressed their metastatic ability without suppressing their tumorigenicity.	hyaluronate	64-75	CD44 molecule (Indian blood group)	Rattus norvegicus	37-41
9739051-2	1998	CD44 on lymphocytes that has been "activated" to bind its principal ligand hyaluronate (HA) on endothelium can mediate the primary adhesion (rolling) of lymphocytes to vascular endothelial cells under conditions of physiologic shear stress, and this interaction is used for activated T cell extravasation into an inflamed site in vivo in mice (DeGrendele, H.C., P. Estess, L.J.	hyaluronate	75-86	CD44 antigen	Mus musculus	0-4
9839619-2	1998	Seeding and culturing L929 cells onto the matrix of serum fetuin and the hyaluronate-binding inter-alpha-inhibitor resulted in inhibition of hyaluronidase-enhanced TNF killing, suggesting that the release of these proteins from hyaluronidase-degraded matrix confers cellular TNF susceptibility.	hyaluronate	73-84	tumor necrosis factor	Mus musculus	164-167
9839619-2	1998	Seeding and culturing L929 cells onto the matrix of serum fetuin and the hyaluronate-binding inter-alpha-inhibitor resulted in inhibition of hyaluronidase-enhanced TNF killing, suggesting that the release of these proteins from hyaluronidase-degraded matrix confers cellular TNF susceptibility.	hyaluronate	73-84	tumor necrosis factor	Mus musculus	275-278
9618391-5	1998	Despite increased expression, neither fresh nor cytokine-cultured EOS adhered to immobilized hyaluronate, a ligand for CD44.	hyaluronate	93-104	CD44 molecule (Indian blood group)	Homo sapiens	119-123
9609138-2	1998	CD44, the principal cell-surface receptor for hyaluronate, and its numerous splice variants have been reported to play a crucial role in invasion and the metastatic process of different human neoplasms, including primary malignant melanoma (PMM).	hyaluronate	46-57	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9614382-2	1998	Among the numerous extracellular matrix components, hyaluronate, a CD44 ligand, is of increasing interest in relation to its role in cancer cell development and invasion.	hyaluronate	52-63	CD44 molecule (Indian blood group)	Homo sapiens	67-71
9614382-5	1998	The hyaluronate binding activity of V5 and V6-positive cells could be restored by pretreatment with anti-CD44 V5 and V6 monoclonal antibodies (MAbs).	hyaluronate	4-15	CD44 molecule (Indian blood group)	Homo sapiens	105-109
9399665-0	1997	Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III.	hyaluronate	64-75	CD44 antigen	Mus musculus	33-37
9560786-0	1998	Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis.	hyaluronate	65-76	hepatocyte growth factor	Rattus norvegicus	31-55
9560786-1	1998	Effects of the deleted form of hepatocyte growth factor (dHGF) on serum hyaluronate levels, an index for liver cirrhosis, were studied in rats.	hyaluronate	72-83	hepatocyte growth factor	Rattus norvegicus	31-55
9399665-4	1997	CD44-mediated adhesion to immobilized hyaluronate and the binding of fluorescence-labeled hyaluronate to the cell surface were increased in positive transfectants.	hyaluronate	38-49	CD44 antigen	Mus musculus	0-4
9242547-8	1997	The physiological impact of this upregulation was shown by the enhanced binding of EC to hyaluronate after pretreatment with bFGF.	hyaluronate	89-100	fibroblast growth factor 2	Homo sapiens	125-129
9399665-4	1997	CD44-mediated adhesion to immobilized hyaluronate and the binding of fluorescence-labeled hyaluronate to the cell surface were increased in positive transfectants.	hyaluronate	90-101	CD44 antigen	Mus musculus	0-4
9399665-7	1997	These results indicate that glycosylation of CD44 due to GnT-III causes enhanced adhesion to hyaluronate, local tumor growth and metastatic growth in spleen, suggesting that the CD44-mediated adhesion and tumor spread can be modified through introduction of a glycosyltransferase gene.	hyaluronate	93-104	CD44 antigen	Mus musculus	45-49
9399665-7	1997	These results indicate that glycosylation of CD44 due to GnT-III causes enhanced adhesion to hyaluronate, local tumor growth and metastatic growth in spleen, suggesting that the CD44-mediated adhesion and tumor spread can be modified through introduction of a glycosyltransferase gene.	hyaluronate	93-104	mannoside acetylglucosaminyltransferase 3	Mus musculus	57-64
9399665-7	1997	These results indicate that glycosylation of CD44 due to GnT-III causes enhanced adhesion to hyaluronate, local tumor growth and metastatic growth in spleen, suggesting that the CD44-mediated adhesion and tumor spread can be modified through introduction of a glycosyltransferase gene.	hyaluronate	93-104	CD44 antigen	Mus musculus	178-182
9395530-6	1997	A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface.	hyaluronate	47-58	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9395530-6	1997	A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface.	hyaluronate	47-58	CD44 molecule (Indian blood group)	Homo sapiens	324-328
9395530-6	1997	A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface.	hyaluronate	94-105	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9395530-6	1997	A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface.	hyaluronate	94-105	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9136928-0	1997	Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.	hyaluronate	137-148	CD44 antigen	Mus musculus	25-29
9143269-2	1997	A multifunctional adhesion molecule CD44 partially mediates binding of lymphocytes to the white matter by interacting with hyaluronate.	hyaluronate	123-134	CD44 molecule (Indian blood group)	Homo sapiens	36-40
9143269-7	1997	Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants.	hyaluronate	48-59	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9143269-7	1997	Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants.	hyaluronate	48-59	CD44 molecule (Indian blood group)	Homo sapiens	117-121
9143269-7	1997	Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants.	hyaluronate	48-59	CD44 molecule (Indian blood group)	Homo sapiens	117-121
9143269-7	1997	Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants.	hyaluronate	178-189	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9143269-10	1997	(b) The only ligand of CD44 in the central nervous system (CNS) white matter is hyaluronate.	hyaluronate	80-91	CD44 molecule (Indian blood group)	Homo sapiens	23-27
9136928-0	1997	Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.	hyaluronate	137-148	CD44 antigen	Mus musculus	76-80
9136928-1	1997	CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate.	hyaluronate	110-121	CD44 antigen	Mus musculus	0-4
9136928-2	1997	Although CD44-mediated cell interaction with hyaluronate has been implicated in a variety of physiologic events, including cell-cell and cell-substrate adhesion, cell migration, proliferation, and activation, as well as hyaluronate uptake and degradation, the biologic role of CD44 in vivo in various tissues remains to be determined.	hyaluronate	45-56	CD44 antigen	Mus musculus	9-13
9136928-2	1997	Although CD44-mediated cell interaction with hyaluronate has been implicated in a variety of physiologic events, including cell-cell and cell-substrate adhesion, cell migration, proliferation, and activation, as well as hyaluronate uptake and degradation, the biologic role of CD44 in vivo in various tissues remains to be determined.	hyaluronate	45-56	CD44 antigen	Mus musculus	277-281
9136928-6	1997	Our observations indicate that two major functions of CD44 in skin are the regulation of keratinocyte proliferation in response to extracellular stimuli and the maintenance of local hyaluronate homeostasis.	hyaluronate	182-193	CD44 antigen	Mus musculus	54-58
9085219-5	1997	Interestingly, we first revealed that CD44 molecules (hyaluronate receptor) on lymphocytes also participated in lymphocyte-HGF interactions and that hyaluronate anchored on the surface of HGF functioned as the ligand for CD44.	hyaluronate	54-65	CD44 molecule (Indian blood group)	Homo sapiens	38-42
21533413-0	1997	Hyaluronate activates tyrosine phosphorylation of cellular proteins including focal adhesion kinase via CD44 in human glioma cells.	hyaluronate	0-11	CD44 molecule (Indian blood group)	Homo sapiens	104-108
21533413-1	1997	To search for the signaling pathway of glioma cells relevant to its aggressive behavior, we examined hyaluronate-CD44 signaling.	hyaluronate	101-112	CD44 molecule (Indian blood group)	Homo sapiens	113-117
21533413-3	1997	Treatment of glioma cells with hyaluronate activated rapid and transient tyrosine phosphorylation of several proteins including p125(FAK), while neuroblastoma cells that express no detectable CD44 had no response to the treatment.	hyaluronate	31-42	SEC23 interacting protein	Homo sapiens	128-132
21533413-3	1997	Treatment of glioma cells with hyaluronate activated rapid and transient tyrosine phosphorylation of several proteins including p125(FAK), while neuroblastoma cells that express no detectable CD44 had no response to the treatment.	hyaluronate	31-42	protein tyrosine kinase 2	Homo sapiens	133-136
21533413-3	1997	Treatment of glioma cells with hyaluronate activated rapid and transient tyrosine phosphorylation of several proteins including p125(FAK), while neuroblastoma cells that express no detectable CD44 had no response to the treatment.	hyaluronate	31-42	CD44 molecule (Indian blood group)	Homo sapiens	192-196
21533413-4	1997	This hyaluronate-dependent tyrosine phosphorylation was blocked by anti-CD44 antibody, suggesting its direct mediation by CD44.	hyaluronate	5-16	CD44 molecule (Indian blood group)	Homo sapiens	72-76
21533413-4	1997	This hyaluronate-dependent tyrosine phosphorylation was blocked by anti-CD44 antibody, suggesting its direct mediation by CD44.	hyaluronate	5-16	CD44 molecule (Indian blood group)	Homo sapiens	122-126
21533413-6	1997	These results strongly suggest that hyaluronate-CD44 signaling may play a role in tumor invasion and proliferation by activation of p125(FAK) and MAP kinase in human glioma cells.	hyaluronate	36-47	CD44 molecule (Indian blood group)	Homo sapiens	48-52
9058839-6	1997	In binding studies sCD44 was able to adhere to hyaluronate and fibronectin, and moreover, sCD44 was able to block the binding of hyaluronate to CD44 on the cell surface and to block the binding of lymphocytes to high endothelial venules, suggesting that sCD44 retains its biological activity although it does not contain the cytoplasmic tail.	hyaluronate	47-58	CD44 molecule (Indian blood group)	Homo sapiens	20-24
21533413-6	1997	These results strongly suggest that hyaluronate-CD44 signaling may play a role in tumor invasion and proliferation by activation of p125(FAK) and MAP kinase in human glioma cells.	hyaluronate	36-47	protein tyrosine kinase 2	Homo sapiens	132-141
9085219-5	1997	Interestingly, we first revealed that CD44 molecules (hyaluronate receptor) on lymphocytes also participated in lymphocyte-HGF interactions and that hyaluronate anchored on the surface of HGF functioned as the ligand for CD44.	hyaluronate	54-65	hepatocyte growth factor	Homo sapiens	123-126
9641850-3	1997	For hyaluronate and chitosan, applying the Mark-Houwink correction to the calibration curve obtained by pullulan, the acceptable molecular weights could be estimated.	hyaluronate	4-15	microtubule affinity regulating kinase 1	Homo sapiens	43-47
9010911-4	1997	Osteopontin binds to naturally expressed and stably transfected CD44 in a manner that is specific, dose-dependent, inhibitable by anti-CD44 antibodies, insensitive to competition by Gly-Arg-Gly-Asp-Ser, and sensitive to competition by hyaluronate.	hyaluronate	235-246	secreted phosphoprotein 1	Homo sapiens	0-11
9010911-4	1997	Osteopontin binds to naturally expressed and stably transfected CD44 in a manner that is specific, dose-dependent, inhibitable by anti-CD44 antibodies, insensitive to competition by Gly-Arg-Gly-Asp-Ser, and sensitive to competition by hyaluronate.	hyaluronate	235-246	CD44 molecule (Indian blood group)	Homo sapiens	64-68
9010911-6	1997	In contrast, binding of CD44 to hyaluronate mediates aggregation or attachment but not chemotaxis.	hyaluronate	32-43	CD44 molecule (Indian blood group)	Homo sapiens	24-28
8858111-0	1996	O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells.	hyaluronate	49-60	CD44 molecule (Indian blood group)	Homo sapiens	32-36
9228671-1	1997	CD44 is the principal cell surface receptor for hyaluronate.	hyaluronate	48-59	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8977706-1	1996	CD44 is the major human cell surface receptor for hyaluronate and functions in a diverse range of physiological processes.	hyaluronate	50-61	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8981904-7	1996	In implants supplemented with 0.04 microg basic fibroblast growth factor in a hyaluronate gel carrier, the bone ingrowth distance was increased by 70% at 6 weeks, as compared with paired controls in the contralateral leg.	hyaluronate	78-89	fibroblast growth factor 2	Rattus norvegicus	42-72
8981904-9	1996	When the dose of basic fibroblast growth factor was increased to 1.0 microg, still using the hyaluronate carrier, there was no difference in bone ingrowth compared with controls, but this dose still increased the total tissue ingrowth.	hyaluronate	93-104	fibroblast growth factor 2	Rattus norvegicus	17-47
9178582-5	1996	Hyaluronate appears the main GAG represented while dermatan sulfate the minor one.	hyaluronate	0-11	uncharacterized LOC107052719	Gallus gallus	29-32
8858111-6	1996	Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44.	hyaluronate	129-140	CD44 molecule (Indian blood group)	Homo sapiens	28-32
8858111-6	1996	Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44.	hyaluronate	129-140	CD44 molecule (Indian blood group)	Homo sapiens	71-75
8858111-6	1996	Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44.	hyaluronate	129-140	CD44 molecule (Indian blood group)	Homo sapiens	71-75
8906122-0	1996	CD44-hyaluronate interaction participates in the adherence of T-lymphocytes to gingival fibroblasts.	hyaluronate	5-16	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8769429-1	1996	I. De-adhesion from hyaluronate by shedding of CD44.	hyaluronate	20-31	CD44 molecule (Indian blood group)	Homo sapiens	47-51
8769429-3	1996	Induction of apoptosis in adherent gamma interferon-stimulated HT-29 and COLO 205 colon carcinoma cells by cross-linking CD95 with anti-APO-1 monoclonal antibody resulted in detachment of the cells from hyaluronate starting about 1 h after antibody exposure.	hyaluronate	203-214	Fas cell surface death receptor	Homo sapiens	121-125
8769429-3	1996	Induction of apoptosis in adherent gamma interferon-stimulated HT-29 and COLO 205 colon carcinoma cells by cross-linking CD95 with anti-APO-1 monoclonal antibody resulted in detachment of the cells from hyaluronate starting about 1 h after antibody exposure.	hyaluronate	203-214	Fas cell surface death receptor	Homo sapiens	136-141
8906122-4	1996	It was confirmed that PMA-activated T-lymphocytes strongly adhered to plate-coated hyaluronate and that the hyaluronate binding was clearly inhibited by the addition of OS/37, a newly established mAb specific for the hyaluronate-binding epitope on CD44.	hyaluronate	108-119	CD44 molecule (Indian blood group)	Homo sapiens	248-252
8906122-4	1996	It was confirmed that PMA-activated T-lymphocytes strongly adhered to plate-coated hyaluronate and that the hyaluronate binding was clearly inhibited by the addition of OS/37, a newly established mAb specific for the hyaluronate-binding epitope on CD44.	hyaluronate	108-119	CD44 molecule (Indian blood group)	Homo sapiens	248-252
8906122-6	1996	Immunofluorescence staining revealed that hyaluronate was anchored along the cell surface of HGF.	hyaluronate	42-53	hepatocyte growth factor	Homo sapiens	93-96
8906122-8	1996	These results clearly demonstrated that CD44-hyaluronate interactions participated at least in part in the adhesiveness of T-lymphocytes to HGF.	hyaluronate	45-56	CD44 molecule (Indian blood group)	Homo sapiens	40-44
8906122-8	1996	These results clearly demonstrated that CD44-hyaluronate interactions participated at least in part in the adhesiveness of T-lymphocytes to HGF.	hyaluronate	45-56	hepatocyte growth factor	Homo sapiens	140-143
7537174-1	1995	CD44 is the transmembrane adhesion molecule which binds hyaluronate.	hyaluronate	56-67	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8674073-0	1996	Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells.	hyaluronate	0-11	CD44 molecule (Indian blood group)	Rattus norvegicus	47-51
8674073-2	1996	The CD44 proteins carry amino acid sequence motifs that confer the ability to bind to the extracellular matrix component hyaluronate (HA).	hyaluronate	121-132	CD44 molecule (Indian blood group)	Rattus norvegicus	4-8
8690089-0	1996	The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily.	hyaluronate	24-35	CD44 molecule (Indian blood group)	Homo sapiens	108-112
8629452-14	1996	Hyaluronate gel was effective as a slow-release carrier for bFGF.	hyaluronate	0-11	fibroblast growth factor 2	Homo sapiens	60-64
8570172-0	1995	CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas.	hyaluronate	5-16	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8570172-6	1995	Examination of several colon carcinoma cell lines and use of mutant CD44H reveal that this in vitro and in vivo growth reduction requires the ability of CD44H to bind hyaluronate.	hyaluronate	167-178	CD44 molecule (Indian blood group)	Homo sapiens	68-72
8570172-6	1995	Examination of several colon carcinoma cell lines and use of mutant CD44H reveal that this in vitro and in vivo growth reduction requires the ability of CD44H to bind hyaluronate.	hyaluronate	167-178	CD44 molecule (Indian blood group)	Homo sapiens	153-157
8526845-1	1995	Glial hyaluronate-binding protein (GHAP) is a 60 kDa glycoprotein with an amino acid sequence identical to that of the hyaluronate-binding region of versican, a large fibroblast aggregating proteoglycan found in the brain.	hyaluronate	6-17	versican	Homo sapiens	35-39
8750183-5	1995	Furthermore, we found that these cell lines bind hyaluronate, and that their cell surface hyaluronate binding correlates with CD44 expression.	hyaluronate	90-101	CD44 molecule (Indian blood group)	Rattus norvegicus	126-130
8750184-9	1995	We envisage that CD44 isoforms, in particular CD44s, may contribute to the invasive character of primary tumors by interacting with hyaluronate, one of the most abundant molecules in the extracellular matrix of the brain.	hyaluronate	132-143	CD44 molecule (Indian blood group)	Homo sapiens	17-21
8750184-9	1995	We envisage that CD44 isoforms, in particular CD44s, may contribute to the invasive character of primary tumors by interacting with hyaluronate, one of the most abundant molecules in the extracellular matrix of the brain.	hyaluronate	132-143	CD44 molecule (Indian blood group)	Homo sapiens	46-50
7545390-0	1995	Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type.	hyaluronate	42-53	CD44 molecule (Indian blood group)	Homo sapiens	34-38
7794051-0	1995	Synovial hyaluronate in rheumatoid arthritis binds C1q and is covalently bound to antibodies: a model for chronicity.	hyaluronate	9-20	complement C1q A chain	Homo sapiens	51-54
8621620-0	1996	Keratan sulfate modification of CD44 modulates adhesion to hyaluronate.	hyaluronate	59-70	CD44 molecule (Indian blood group)	Homo sapiens	32-36
8621620-3	1996	In the current study, we have demonstrated that keratan sulfate modification of CD44 significantly modulates its ability to bind to hyaluronate.	hyaluronate	132-143	CD44 molecule (Indian blood group)	Homo sapiens	80-84
8621620-7	1996	Removal of keratan sulfate from CD44 greatly enhanced CD44-mediated cell adhesion to hyaluronate.	hyaluronate	85-96	CD44 molecule (Indian blood group)	Homo sapiens	32-36
8621620-7	1996	Removal of keratan sulfate from CD44 greatly enhanced CD44-mediated cell adhesion to hyaluronate.	hyaluronate	85-96	CD44 molecule (Indian blood group)	Homo sapiens	54-58
8621620-10	1996	Use of site-directed CD44H cDNA mutants with arginine changed to alanine at position 41 indicated that keratan sulfate modification of CD44 modulates hyaluronate adhesion through its B loop domain.	hyaluronate	150-161	CD44 molecule (Indian blood group)	Homo sapiens	21-25
8621620-10	1996	Use of site-directed CD44H cDNA mutants with arginine changed to alanine at position 41 indicated that keratan sulfate modification of CD44 modulates hyaluronate adhesion through its B loop domain.	hyaluronate	150-161	CD44 molecule (Indian blood group)	Homo sapiens	135-139
8560266-3	1996	Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate.	hyaluronate	159-170	CD44 molecule (Indian blood group)	Homo sapiens	127-131
8560266-4	1996	The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth.	hyaluronate	78-89	CD44 molecule (Indian blood group)	Homo sapiens	39-43
8560266-4	1996	The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth.	hyaluronate	78-89	CD44 molecule (Indian blood group)	Homo sapiens	133-137
7542295-1	1995	CD44 is a principal cell-surface receptor for hyaluronate and is found on a wide variety of cells.	hyaluronate	46-57	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9815989-2	1995	CD44 is a major receptor for hyaluronate and exists as a standard 90-180-kDa form (CD44H), as well as several higher molecular mass variant forms produced by alternative splicing.	hyaluronate	29-40	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7528778-0	1995	Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain.	hyaluronate	30-41	CD44 molecule (Indian blood group)	Homo sapiens	53-57
7523494-11	1994	Serum with high concentrations of CD44 partially blocked the binding of one ligand, hyaluronate, to CD44-bearing hybridoma cells.	hyaluronate	84-95	CD44 antigen	Mus musculus	34-38
7523494-11	1994	Serum with high concentrations of CD44 partially blocked the binding of one ligand, hyaluronate, to CD44-bearing hybridoma cells.	hyaluronate	84-95	CD44 antigen	Mus musculus	100-104
8093047-0	1994	Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity.	hyaluronate	78-89	CD53 molecule	Homo sapiens	0-20
8093047-0	1994	Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity.	hyaluronate	78-89	CD38 molecule	Homo sapiens	21-25
8093047-0	1994	Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity.	hyaluronate	78-89	tripartite motif containing 33	Homo sapiens	40-44
8093047-6	1994	A putative hyaluronate (HA)-binding motif which has recently been identified in CD44 antigen existed in the extracellular domain and intracellular amino terminus of CD38 antigen.	hyaluronate	11-22	CD44 molecule (Indian blood group)	Homo sapiens	80-84
8093047-6	1994	A putative hyaluronate (HA)-binding motif which has recently been identified in CD44 antigen existed in the extracellular domain and intracellular amino terminus of CD38 antigen.	hyaluronate	11-22	CD38 molecule	Homo sapiens	165-169
7515923-0	1994	Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells.	hyaluronate	0-11	CD44 molecule (Indian blood group)	Homo sapiens	78-82
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	hyaluronate	19-30	CD44 molecule (Indian blood group)	Homo sapiens	39-43
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	hyaluronate	19-30	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	76-79
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	hyaluronate	19-30	interleukin 2	Homo sapiens	168-172
7525670-1	1994	CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate.	hyaluronate	214-225	CD44 molecule (Indian blood group)	Homo sapiens	0-4
8013670-5	1994	These results suggest that a hyaluronate-depolymerizing enzyme, endo-beta-N-acetylglucosaminidase, was induced by progesterone in cultured fibroblasts derived from human uterine cervix.	hyaluronate	29-40	endo-beta-N-acetylglucosaminidase	Homo sapiens	64-97
7514542-7	1994	Hyaluronate is known as the ligand of CD44, but neither hyaluronidase treatment nor addition of excess hyaluronate to the assay system affected rosette formation.	hyaluronate	0-11	CD44 antigen	Mus musculus	38-42
7514542-9	1994	Anti-CD44 antibody (KM81), which recognized the hyaluronate binding site of CD44, inhibited rosette formation.	hyaluronate	48-59	CD44 antigen	Mus musculus	5-9
7514542-9	1994	Anti-CD44 antibody (KM81), which recognized the hyaluronate binding site of CD44, inhibited rosette formation.	hyaluronate	48-59	CD44 antigen	Mus musculus	76-80
7514542-10	1994	But other monoclonal antibodies against different epitopes except for the hyaluronate binding site, even those against CD44"s hyaluronate binding site, did not inhibit rosette formation.	hyaluronate	126-137	CD44 antigen	Mus musculus	119-123
7513749-0	1994	CD44-hyaluronate interaction mediates in vitro lymphocyte binding to the white matter of the central nervous system.	hyaluronate	5-16	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7513749-1	1994	The cell adhesion molecule CD44 is expressed in the central nervous system, especially on glial cells in the white matter, the extracellular matrix of which also contains one of its ligands, hyaluronate.	hyaluronate	191-202	CD44 molecule (Indian blood group)	Homo sapiens	27-31
7513749-3	1994	Hermes-1 epitope, which recognizes the hyaluronate binding site of CD44, and Hermes-3 epitope, involved in lymphocyte binding to mucosal high endothelial venules, were both immunohistochemically expressed in the white matter.	hyaluronate	39-50	CD44 molecule (Indian blood group)	Homo sapiens	67-71
7508696-0	1993	Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.	hyaluronate	44-55	tenascin C	Rattus norvegicus	18-26
7506725-0	1994	Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis.	hyaluronate	42-53	CD44 molecule (Indian blood group)	Homo sapiens	58-62
7527678-3	1994	We found that very late antigen-4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) were major adhesion molecules in lymphoid and myeloid cells, whereas myeloma cells adhered to stromal cells through hyaluronate.	hyaluronate	205-216	vascular cell adhesion molecule 1	Homo sapiens	81-87
7531501-2	1994	CD44 properties in vitro include hyaluronate-mediated adhesion, motility, hyaluronate degradation, self-aggregation, and adhesion to lymphoid tissue.	hyaluronate	33-44	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7531501-2	1994	CD44 properties in vitro include hyaluronate-mediated adhesion, motility, hyaluronate degradation, self-aggregation, and adhesion to lymphoid tissue.	hyaluronate	74-85	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7508696-0	1993	Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.	hyaluronate	44-55	versican	Rattus norvegicus	32-40
7507884-3	1993	To examine the role of CD44 on these cells, and to ascertain its ligand, we analysed the ability of the early thymic precursor cells to bind hyaluronate (HA) which functions as a cell adhesion molecule and a ligand for CD44.	hyaluronate	141-152	CD44 antigen	Mus musculus	23-27
7515731-4	1993	CD44 isoforms belong to the family of cell adhesion molecules and to the sub-family of the hyaladherins in consideration of their affinity for hyaluronate and their structural homology with the cartilage link protein.	hyaluronate	143-154	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7515731-5	1993	The standard form of CD44, CD44H exhibits a high affinity for hyaluronate, plays a role in the uptake and degradation of this glycosaminoglycan and participates in cell locomotion in its presence.	hyaluronate	62-73	CD44 molecule (Indian blood group)	Homo sapiens	21-25
7515731-8	1993	The variant form CD44E exhibits low affinity for hyaluronate and its role in cell-cell adhesion in epithelia is suspected.	hyaluronate	49-60	CD44 molecule (Indian blood group)	Homo sapiens	17-21
8354694-9	1993	Dose-dependent inhibition of adhesion by hyaluronate and by anti-CD44 monoclonal antibody KM81 shows that CD44 is involved in the adhesive interactions between T cells and astrocytes.	hyaluronate	41-52	CD44 antigen	Mus musculus	106-110
7507884-3	1993	To examine the role of CD44 on these cells, and to ascertain its ligand, we analysed the ability of the early thymic precursor cells to bind hyaluronate (HA) which functions as a cell adhesion molecule and a ligand for CD44.	hyaluronate	141-152	CD44 antigen	Mus musculus	219-223
8353136-0	1993	Regulation of hyaluronate production by interleukin 1 in cultured human chorionic cells.	hyaluronate	14-25	interleukin 1 alpha	Homo sapiens	40-53
8353136-2	1993	When these cells were treated with human recombinant interleukin 1 alpha (hrIL-1), the biosynthesis and secretion of hyaluronate were predominantly accelerated, but those of sulfated glycosaminoglycans were not modulated.	hyaluronate	117-128	interleukin 1 alpha	Homo sapiens	53-72
7521750-8	1993	The binding of p80 to hyaluronate was pH dependent with a maximum at pH 6.4.	hyaluronate	22-33	coilin	Homo sapiens	15-18
8366214-1	1993	CD44 is the principal cell surface receptor for hyaluronate.	hyaluronate	48-59	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7678658-0	1993	Versican, a hyaluronate-binding proteoglycan of embryonal precartilaginous mesenchyma, is mainly expressed postnatally in rat brain.	hyaluronate	12-23	versican	Rattus norvegicus	0-8
8472428-1	1993	Hyaluronate (HA) is linear unbranched polysaccharide consisting of repeating disaccharide units of (1-4)-D-glucuronic acid-beta-(1-3)-D-N-acetylglucosamine.	hyaluronate	0-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	123-132
1429726-13	1992	We conclude that the protein-hyaluronate aggregates in brain ECM contain both GHAP and versican, that GHAP is only retained in the ECM by its interaction with hyaluronate, and that the proteoglycan is anchored in some other manner and probably connects cell surfaces with the ECM since it was not released by hyaluronidase digestion.	hyaluronate	29-40	versican	Homo sapiens	87-95
1429726-13	1992	We conclude that the protein-hyaluronate aggregates in brain ECM contain both GHAP and versican, that GHAP is only retained in the ECM by its interaction with hyaluronate, and that the proteoglycan is anchored in some other manner and probably connects cell surfaces with the ECM since it was not released by hyaluronidase digestion.	hyaluronate	29-40	versican	Homo sapiens	78-82
1469058-1	1992	We previously found that the CD44 glycoprotein on some lymphocytes can mediate adhesion to hyaluronate (HA) bearing cells.	hyaluronate	91-102	CD44 antigen	Mus musculus	29-33
1426053-1	1992	CD44 is an integral membrane glycoprotein of approximately 90 kDa which has been implicated in the binding of hyaluronate to the cell surface.	hyaluronate	110-121	CD44 molecule (Indian blood group)	Homo sapiens	0-4
1388188-3	1992	Analysis of CD45 by flow cytometry revealed that unstimulated and stimulated B cells expressed homogeneous amounts of total CD45 but that stimulation with IL-5 resulted in a CD44hi, hyaluronate-adherent subpopulation of activated B cells that expressed a markedly altered pattern of expression of exon-specific CD45R or B220 determinants.	hyaluronate	182-193	interleukin 5	Mus musculus	155-159
1388188-5	1992	In contrast, the CD45 proteins immunoprecipitated from the hyaluronate-adherent subpopulation of IL-5-activated B cells were predominantly lower m.w.	hyaluronate	59-70	protein tyrosine phosphatase, receptor type, C	Mus musculus	17-21
1388188-5	1992	In contrast, the CD45 proteins immunoprecipitated from the hyaluronate-adherent subpopulation of IL-5-activated B cells were predominantly lower m.w.	hyaluronate	59-70	interleukin 5	Mus musculus	97-101
1388188-8	1992	The highest molecular size PCR product, corresponding to expression of all three variably expressed CD45 exons (A, B, and C) was prominent in resting B cells and in LPS-activated B cells but was selectively reduced in hyaluronate-adherent IL-5-activated B cells, where lower molecular size PCR products predominated, corresponding to expression of one or two of the variable exons.	hyaluronate	218-229	protein tyrosine phosphatase, receptor type, C	Mus musculus	100-104
1388188-8	1992	The highest molecular size PCR product, corresponding to expression of all three variably expressed CD45 exons (A, B, and C) was prominent in resting B cells and in LPS-activated B cells but was selectively reduced in hyaluronate-adherent IL-5-activated B cells, where lower molecular size PCR products predominated, corresponding to expression of one or two of the variable exons.	hyaluronate	218-229	interleukin 5	Mus musculus	239-243
1577773-0	1992	Hyaluronate binding properties of versican.	hyaluronate	0-11	versican core protein	Cricetulus griseus	34-42
1380003-0	1992	CD44H regulates tumor cell migration on hyaluronate-coated substrate.	hyaluronate	40-51	CD44 molecule (Indian blood group)	Homo sapiens	0-4
1380003-6	1992	However, cells expressing CD44H cytoplasmic deletion mutants retain significant binding capacity to hyaluronate-coated substrate.	hyaluronate	100-111	CD44 molecule (Indian blood group)	Homo sapiens	26-30
1500863-1	1992	CD44H is the principal cell surface receptor for hyaluronate, which is a major glycosaminoglycan of the extracellular matrix.	hyaluronate	49-60	CD44 molecule (Indian blood group)	Homo sapiens	0-4
1500863-2	1992	Expression of CD44H is enhanced in a variety of malignant tumors and correlates with tumor aggressiveness, supporting the notion that interaction between CD44H and hyaluronate may play an important role in tumor growth and dissemination.	hyaluronate	164-175	CD44 molecule (Indian blood group)	Homo sapiens	14-18
1281019-14	1992	The affinity for hyaluronate can be experimentally regulated and depends on the cytoplasmic domain of CD44.	hyaluronate	17-28	CD44 molecule (Indian blood group)	Homo sapiens	102-106
1577773-2	1992	The primary sequence shows that the N terminus contains sequence homology with known hyaluronate-binding molecule, suggesting that versican can bind hyaluronate.	hyaluronate	85-96	versican core protein	Cricetulus griseus	131-139
1577773-2	1992	The primary sequence shows that the N terminus contains sequence homology with known hyaluronate-binding molecule, suggesting that versican can bind hyaluronate.	hyaluronate	149-160	versican core protein	Cricetulus griseus	131-139
1577773-6	1992	Using hyaluronate affinity chromatography, we show that recombinant versican specifically binds hyaluronate and does not bind to heparin or chondroitin sulfate.	hyaluronate	6-17	versican core protein	Cricetulus griseus	68-76
1577773-6	1992	Using hyaluronate affinity chromatography, we show that recombinant versican specifically binds hyaluronate and does not bind to heparin or chondroitin sulfate.	hyaluronate	96-107	versican core protein	Cricetulus griseus	68-76
1577773-7	1992	The transfected fibroblasts make a 78-kDa truncated form of versican that also binds hyaluronate and does not bind the related polysaccharides, showing that the hyaluronate binding activity resides at the N terminus of versican.	hyaluronate	85-96	versican core protein	Cricetulus griseus	60-68
1577773-7	1992	The transfected fibroblasts make a 78-kDa truncated form of versican that also binds hyaluronate and does not bind the related polysaccharides, showing that the hyaluronate binding activity resides at the N terminus of versican.	hyaluronate	161-172	versican core protein	Cricetulus griseus	60-68
1577773-8	1992	The binding of versican to hyaluronate is substrate-concentration dependent and time dependent and can be competed with unlabeled versican.	hyaluronate	27-38	versican core protein	Cricetulus griseus	15-23
1577773-8	1992	The binding of versican to hyaluronate is substrate-concentration dependent and time dependent and can be competed with unlabeled versican.	hyaluronate	27-38	versican core protein	Cricetulus griseus	130-138
1577773-9	1992	The dissociation constant for versican binding to hyaluronate was determined to be 4 x 10(-9) M.	hyaluronate	50-61	versican core protein	Cricetulus griseus	30-38
1919439-3	1991	Recently, two isoforms of CD44 have been identified: an 80-90 kD form, which has high affinity for cell bound hyaluronate and a 150 kD form which does not mediate attachment to hyaluronate-coated surfaces.	hyaluronate	110-121	CD44 molecule (Indian blood group)	Homo sapiens	26-30
1742741-6	1991	Homotypic aggregation of cells was increased in those cells expressing high levels of CD44, and these variants were also better able to adhere to hyaluronate substrates.	hyaluronate	146-157	CD44 molecule (Indian blood group)	Homo sapiens	86-90
1719988-1	1991	Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis.	hyaluronate	34-45	CD44 molecule (Indian blood group)	Homo sapiens	47-51
1730767-5	1992	The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.	hyaluronate	119-130	TNF alpha induced protein 6	Homo sapiens	39-44
1730767-5	1992	The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.	hyaluronate	119-130	hyaluronan and proteoglycan link protein 1	Homo sapiens	151-173
1730767-5	1992	The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.	hyaluronate	119-130	CD44 molecule (Indian blood group)	Homo sapiens	229-233
1730767-8	1992	Binding of the TSG-6 protein to hyaluronate was demonstrated by coprecipitation.	hyaluronate	32-43	TNF alpha induced protein 6	Homo sapiens	15-20
1922057-2	1991	One of these genes was identified as CD44, which encodes an integral membrane glycoprotein that serves as the principal receptor for hyaluronate and participates in specific cell-cell and cell-extracellular matrix interactions.	hyaluronate	133-144	CD44 molecule (Indian blood group)	Homo sapiens	37-41
1919439-3	1991	Recently, two isoforms of CD44 have been identified: an 80-90 kD form, which has high affinity for cell bound hyaluronate and a 150 kD form which does not mediate attachment to hyaluronate-coated surfaces.	hyaluronate	177-188	CD44 molecule (Indian blood group)	Homo sapiens	26-30
1917024-3	1991	The endothelial cell surface ligand for CD44 is probably a human equivalent of MECA-367 and hyaluronate.	hyaluronate	92-103	CD44 molecule (Indian blood group)	Homo sapiens	40-44
1703543-3	1990	These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44.	hyaluronate	40-51	CD44 molecule (Indian blood group)	Homo sapiens	144-164
2070821-11	1991	The hyaluronate producing cells were typically small, process-bearing, and GFAP+.	hyaluronate	4-15	glial fibrillary acidic protein	Rattus norvegicus	75-79
2070821-13	1991	Type 1 (GFAP+, A2B5-) astrocytes were also active in the synthesis of hyaluronate, to the extent that they were able to coat their substrate with hyaluronate.	hyaluronate	70-81	glial fibrillary acidic protein	Rattus norvegicus	8-12
2070821-13	1991	Type 1 (GFAP+, A2B5-) astrocytes were also active in the synthesis of hyaluronate, to the extent that they were able to coat their substrate with hyaluronate.	hyaluronate	146-157	glial fibrillary acidic protein	Rattus norvegicus	8-12
1871041-0	1991	Effects of viscous hyaluronate-sodium solutions on the nasal absorption of vasopressin and an analogue.	hyaluronate	19-30	arginine vasopressin	Rattus norvegicus	75-86
1871041-1	1991	The effects of viscous solutions of hyaluronate-sodium of various average molecular weights (MW) on the nasal absorption of vasopressin (AVP) and its analogue, 1-deamino-8-D-arginine vasopressin (1-d-8-DAVP), were examined in rats.	hyaluronate	36-47	arginine vasopressin	Rattus norvegicus	124-135
1993837-1	1991	Identification of a CD44hi population that binds specifically to hyaluronate.	hyaluronate	65-76	CD44 antigen	Mus musculus	20-24
1993837-3	1991	We recently demonstrated that IL-5 stimulation in vitro induces the appearance of a distinct CD44hi Ialow CD45Rlow B cell subpopulation that has aquired the ability to bind to hyaluronate (HA), one of the ligands for CD44, and that this B cell subpopulation is enriched in both proliferative and Ig-secretory responses.	hyaluronate	176-187	interleukin 5	Mus musculus	30-34
1993837-3	1991	We recently demonstrated that IL-5 stimulation in vitro induces the appearance of a distinct CD44hi Ialow CD45Rlow B cell subpopulation that has aquired the ability to bind to hyaluronate (HA), one of the ligands for CD44, and that this B cell subpopulation is enriched in both proliferative and Ig-secretory responses.	hyaluronate	176-187	CD44 antigen	Mus musculus	93-97
1993837-3	1991	We recently demonstrated that IL-5 stimulation in vitro induces the appearance of a distinct CD44hi Ialow CD45Rlow B cell subpopulation that has aquired the ability to bind to hyaluronate (HA), one of the ligands for CD44, and that this B cell subpopulation is enriched in both proliferative and Ig-secretory responses.	hyaluronate	176-187	CD44 antigen	Mus musculus	217-221
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	hyaluronate	189-200	glial fibrillary acidic protein	Homo sapiens	68-99
1914415-0	1991	Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells.	hyaluronate	27-38	interleukin 1 alpha	Homo sapiens	10-23
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	hyaluronate	52-63	interleukin 1 alpha	Homo sapiens	0-13
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	hyaluronate	52-63	interleukin 1 alpha	Homo sapiens	15-19
1713274-1	1991	Monoclonal antibodies were raised against human glial hyaluronate-binding protein (GHAP), a major CNS-specific glycoprotein known to bind hyaluronate in vitro.	hyaluronate	54-65	versican	Homo sapiens	83-87
1713274-13	1991	These findings imply that GHAP exists in association with hyaluronate in CNS white matter.	hyaluronate	58-69	versican	Homo sapiens	26-30
1991450-1	1991	CD44 is a polymorphic integral membrane protein which recognizes hyaluronate and whose proposed roles encompass lymphocyte activation, matrix adhesion and the attachment of lymphocytes to lymph node high endothelial venules (HEVs).	hyaluronate	65-76	CD44 molecule (Indian blood group)	Rattus norvegicus	0-4
1703543-3	1990	These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44.	hyaluronate	40-51	CD44 molecule (Indian blood group)	Homo sapiens	181-185
1703543-4	1990	In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells.	hyaluronate	100-111	CD44 antigen	Mus musculus	54-58
1703543-4	1990	In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells.	hyaluronate	142-153	CD44 antigen	Mus musculus	54-58
1703543-8	1990	Thus, CD44 appears to have at least two distinct functional domains, one for binding hyaluronate and another involved in interactions with mucosal high endothelial venules.	hyaluronate	85-96	CD44 antigen	Mus musculus	6-10
1696488-7	1990	These results demonstrate that TGF-beta 1 and TGF-beta 2 stimulate the production of not only collagenous extracellular matrix components, but also dramatically increase the in vivo synthesis of hyaluronate and chondroitin sulfate.	hyaluronate	195-206	transforming growth factor beta-1 proprotein	Cavia porcellus	31-41
2246506-0	1990	IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate.	hyaluronate	136-147	interleukin 5	Homo sapiens	0-4
2246506-0	1990	IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate.	hyaluronate	136-147	CD44 molecule (Indian blood group)	Homo sapiens	15-20
2246506-0	1990	IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate.	hyaluronate	136-147	CD44 molecule (Indian blood group)	Homo sapiens	22-26
2246506-6	1990	It was found that IL-5-activated B cells bound strongly to hyaluronate-coated surface, and this binding was specifically inhibited by anti-Pgp-1 Ab.	hyaluronate	59-70	interleukin 5	Homo sapiens	18-22
2246506-6	1990	It was found that IL-5-activated B cells bound strongly to hyaluronate-coated surface, and this binding was specifically inhibited by anti-Pgp-1 Ab.	hyaluronate	59-70	CD44 molecule (Indian blood group)	Homo sapiens	139-144
2246506-8	1990	Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells.	hyaluronate	66-77	CD44 molecule (Indian blood group)	Homo sapiens	14-19
2246506-8	1990	Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells.	hyaluronate	66-77	interleukin 5	Homo sapiens	37-41
2246506-8	1990	Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells.	hyaluronate	66-77	CD44 molecule (Indian blood group)	Homo sapiens	83-88
2246506-8	1990	Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells.	hyaluronate	66-77	CD44 molecule (Indian blood group)	Homo sapiens	83-88
2193100-0	1990	Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.	hyaluronate	78-89	CD44 molecule (Indian blood group)	Homo sapiens	57-61
2193100-3	1990	Further investigation has now revealed that hyaluronate is a potential ligand for CD44 and that hyaluronate recognition accounts for the adhesion between B lineage hybridoma and stromal cells.	hyaluronate	44-55	CD44 molecule (Indian blood group)	Homo sapiens	82-86
1696488-7	1990	These results demonstrate that TGF-beta 1 and TGF-beta 2 stimulate the production of not only collagenous extracellular matrix components, but also dramatically increase the in vivo synthesis of hyaluronate and chondroitin sulfate.	hyaluronate	195-206	transforming growth factor, beta 2	Mus musculus	46-56
34245737-3	2021	In this study, we designed and generated a novel nanocarrier composed of chitosan lactate nanoparticles (NPs) functionalized by HIV-1 derived TAT peptide (Transactivating transcriptional activator) and hyaluronate (HA) to deliver CD73 siRNA and doxorubicin to 4T1 and CT26 cancer cells, both in vivo and in vitro, as a novel combinatorial treatment strategy.	hyaluronate	202-213	5'-nucleotidase ecto	Homo sapiens	230-234
1688375-9	1990	Another class of hyaluronate-binding material (25-50% of that recovered) eluted from DEAE with 0.24 M NaCl; this material had the properties of a complex glycoprotein, did not contain chondroitin sulfate, and did not react with the antibodies against cartilage link protein and proteoglycan.	hyaluronate	17-28	hyaluronan and proteoglycan link protein 1	Mus musculus	251-273
34254791-5	2021	The supramolecular hydrogels were prepared to encapsulate fibroblasts by the host-guest interaction of cyclodextrin-modified gelatin (GE-CD) and adamantane-modified hyaluronate (Ad-HA) in conjugation with human growth hormone (hGH) for accelerated skin tissue regeneration.	hyaluronate	165-176	growth hormone 1	Homo sapiens	211-225
34254791-5	2021	The supramolecular hydrogels were prepared to encapsulate fibroblasts by the host-guest interaction of cyclodextrin-modified gelatin (GE-CD) and adamantane-modified hyaluronate (Ad-HA) in conjugation with human growth hormone (hGH) for accelerated skin tissue regeneration.	hyaluronate	165-176	gamma-glutamyl hydrolase	Homo sapiens	227-230
2820777-6	1987	Furthermore, a significant correlation was observed in the lavage fluid between hyaluronate and angiotensin-converting enzyme, a marker of monocyte/macrophage activity (p less than 0.01).	hyaluronate	80-91	angiotensin I converting enzyme	Homo sapiens	96-125
2774697-4	1989	Hyaluronate concentration and degree of polymerisation also correlated with the quality of mucin clot, though only HPLC provided more detailed quantitative information about this association.	hyaluronate	0-11	LOC100508689	Homo sapiens	91-96
2466850-9	1989	Indeed, in many cases, the distribution of hyaluronate closely paralleled that of the hyaluronate receptor.	hyaluronate	43-54	CD44 antigen	Mus musculus	86-106
2478346-0	1989	The interaction of hyaluronate with the cell surface: the hyaluronate receptor and the core protein.	hyaluronate	19-30	CD44 molecule (Indian blood group)	Rattus norvegicus	58-78
2458949-1	1988	To examine the role of the hyaluronate receptor in cell to cell adhesion, we have employed the K-3 monoclonal antibody (MAb) which specifically binds to the hyaluronate receptor and blocks its ability to interact with hyaluronate.	hyaluronate	27-38	CD44 antigen	Mus musculus	157-177
3421941-6	1988	The high resolution of the method allowed examination of the involvement in hyaluronate binding of the globular core-protein domains G1, G2 and G3 [Wiedemann, Paulsson, Timpl, Engel & Heinegard (1984) Biochem.	hyaluronate	76-87	proline rich protein BstNI subfamily 3	Homo sapiens	133-146
34357232-0	2021	Fabrication of Stromal Cell-Derived Factor-1 Contained in Gelatin/Hyaluronate Copo006Cymer Mixed with Hydroxyapatite for Use in Traumatic Bone Defects.	hyaluronate	66-77	C-X-C motif chemokine ligand 12	Rattus norvegicus	15-44
2509244-0	1989	Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells.	hyaluronate	89-100	transforming growth factor alpha	Rattus norvegicus	29-38
2509244-0	1989	Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells.	hyaluronate	89-100	transforming growth factor, beta 1	Rattus norvegicus	43-53
2559493-3	1989	In addition, hyaluronate with 100 micrograms/ml dose caused a displacement of newly formed proteoglycan from cultures into the medium.	hyaluronate	13-24	versican	Gallus gallus	91-103
2437135-10	1987	Thus, it is concluded that the high affinity of binding of hyaluronate to the plasma membrane of SV-3T3 cells is in part dependent on insertion of the HABP in the membrane, but that other interactions, not duplicated in our reconstitution experiments, must be necessary for the specificity of the HABP.	hyaluronate	59-70	hyaluronic acid binding protein 2	Mus musculus	151-155
2437135-6	1987	The characteristics of binding of hyaluronate to the reconstituted HABP were then compared with those studied previously for the original membrane-bound HABP and the detergent-extracted HABP (Underhill et al, J Biol Chem 258:8086-8091, 1983).	hyaluronate	34-45	hyaluronic acid binding protein 2	Mus musculus	67-71
2437135-7	1987	It was observed previously that binding of hyaluronate to HABP in the cell membranes was of higher affinity and specificity than to HABP in the detergent extracts of these membranes.	hyaluronate	43-54	hyaluronic acid binding protein 2	Mus musculus	58-62
2437135-7	1987	It was observed previously that binding of hyaluronate to HABP in the cell membranes was of higher affinity and specificity than to HABP in the detergent extracts of these membranes.	hyaluronate	43-54	hyaluronic acid binding protein 2	Mus musculus	132-136
2437135-10	1987	Thus, it is concluded that the high affinity of binding of hyaluronate to the plasma membrane of SV-3T3 cells is in part dependent on insertion of the HABP in the membrane, but that other interactions, not duplicated in our reconstitution experiments, must be necessary for the specificity of the HABP.	hyaluronate	59-70	hyaluronic acid binding protein 2	Mus musculus	297-301
3710427-7	1986	There was a significant correlation between serum hyaluronate and serum albumin, prothrombin time, factor V concentration and serum gamma-globulins.	hyaluronate	50-61	coagulation factor II, thrombin	Homo sapiens	81-92
3020940-4	1986	Hyaluronate-elicited macrophages show a decreased 5"-nucleotidase and an increased acid phosphatase activity as compared to resident macrophages.	hyaluronate	0-11	5' nucleotidase, ecto	Mus musculus	50-65
3876080-8	1985	Raised levels of beta-thromboglobulin were associated with the highest hyaluronate values.	hyaluronate	71-82	pro-platelet basic protein	Homo sapiens	17-37
3876080-9	1985	Platelet-derived growth factor, which stimulates connective tissue cells and is stored in the alpha-granules of platelets together with beta-thromboglobulin, was shown to enhance hyaluronate synthesis in fibroblast cultures.	hyaluronate	179-190	pro-platelet basic protein	Homo sapiens	136-156
4005166-5	1985	Serum hyaluronate positively correlated with the plasma concentrations of alpha 1-antitrypsin and haptoglobin and also with ESR, which may indicate a relationship between acute inflammation and increased production of hyaluronate.	hyaluronate	6-17	serpin family A member 1	Homo sapiens	74-93
4005166-5	1985	Serum hyaluronate positively correlated with the plasma concentrations of alpha 1-antitrypsin and haptoglobin and also with ESR, which may indicate a relationship between acute inflammation and increased production of hyaluronate.	hyaluronate	6-17	haptoglobin	Homo sapiens	98-109
3989479-4	1985	The sequential application of chondroitinase AC and ABC permits the determination of hyaluronate, the chondroitin sulphate isomers and the dermatan sulphate isomers by high performance liquid chromatographic separation of the products of enzymatic hydrolysis.	hyaluronate	85-96	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	52-55
3970970-5	1985	The substrate specificity of the enzyme was the same as for bovine testicular hyaluronidase; however, both the Km and V values were significantly lower for the pig liver enzyme with all of the substrates tested (hyaluronate, chondroitin 4-sulphate, chondroitin 6-sulphate).	hyaluronate	212-223	hemopexin	Sus scrofa	78-91
3970970-6	1985	A full kinetic analysis of the enzyme using hyaluronate as a substrate showed that the activity of pig liver hyaluronidase was uncompetitively activated by either protons or NaCl.	hyaluronate	44-55	hemopexin	Sus scrofa	109-122
6204647-0	1984	Hyaluronate binding proteins also bind to fibronectin, laminin and collagen.	hyaluronate	0-11	fibronectin 1	Mus musculus	42-53
28305109-4	1984	After degradation of glycosaminoglycans in the living organism, it is shown that this particular site, in fact, also contains fibronectin that is masked in vivo by, at least, hyaluronate.	hyaluronate	175-186	fibronectin 1	Gallus gallus	126-137
6332318-0	1984	Interleukin 1 enhances synovial cell hyaluronate synthesis.	hyaluronate	37-48	interleukin 1 alpha	Homo sapiens	0-13
6332318-3	1984	We report here that interleukin 1 from either source stimulates hyaluronate synthesis by synovial membrane cells.	hyaluronate	64-75	interleukin 1 alpha	Homo sapiens	20-33
6332318-4	1984	Upon gel filtration or isoelectric focusing of synovial cell supernatants, the hyaluronate-stimulatory activity co-fractionates with the interleukin 1 activity.	hyaluronate	79-90	interleukin 1 alpha	Homo sapiens	137-150
6332318-5	1984	Enhanced cell secretion of hyaluronate is a newly described metabolic effect of interleukin 1.	hyaluronate	27-38	interleukin 1 alpha	Homo sapiens	80-93
6870820-7	1983	Membrane-bound pyrophosphatases or 5"-nucleotidase are suggested as modulators of hyaluronate synthesis.	hyaluronate	82-93	5'-nucleotidase ecto	Homo sapiens	35-50
6466805-5	1984	The experimental technique is tested by measurements of the diffusion coefficient of albumin in hyaluronate gels of 0.5%-2.5% (w/v) concentrations and preliminary data are presented on the diffusion of rabbit lipoproteins in similar gels.	hyaluronate	96-107	albumin	Oryctolagus cuniculus	85-92
6411747-7	1983	Hyaluronate added in the medium significantly reduces the extent, speed and directionality of movement on fibronectin substrata.	hyaluronate	0-11	fibronectin 1	Homo sapiens	106-117
7151126-8	1982	Hyaluronate pretreatment also retarded adhesion to adsorbed fibronectin but only when adsorbed collagen was also present.	hyaluronate	0-11	fibronectin 1	Bos taurus	60-71
7340806-0	1981	A comparative study of the binding of cartilage link protein and the hyaluronate-binding region of the cartilage proteoglycan to hyaluronate-substituted Sepharose gel.	hyaluronate	129-140	hyaluronan and proteoglycan link protein 1	Bos taurus	38-60
238649-4	1975	The same was indicated by an increase in the percentage of the aforementioned amino acids and by the absence of sugar alditols in umbilical cord hyaluronate reduced eith NaBH4 -PdCl2, after alkali treatment.	hyaluronate	145-156	phosducin like 2	Homo sapiens	177-182
6459778-2	1981	Hyaluronate extracted from rooster comb was digested by a mixture of beta-N-acetylhexosaminidase and beta-glucuronidase with simultaneous dialysis for 96 h. 2.	hyaluronate	0-11	O-GlcNAcase	Homo sapiens	69-96
6459778-2	1981	Hyaluronate extracted from rooster comb was digested by a mixture of beta-N-acetylhexosaminidase and beta-glucuronidase with simultaneous dialysis for 96 h. 2.	hyaluronate	0-11	glucuronidase beta	Homo sapiens	101-119
6907018-1	1981	The nature of lipoprotein and elastin associated with hyaluronate in human atherosclerotic plaque tissue was studied by digesting the tissues with elastase.	hyaluronate	54-65	elastin	Homo sapiens	30-37
6459778-0	1981	Sequential hydrolysis of hyaluronate by beta-glucuronidase and beta-N-acetylhexosaminidase.	hyaluronate	25-36	glucuronidase beta	Homo sapiens	40-58
6459778-0	1981	Sequential hydrolysis of hyaluronate by beta-glucuronidase and beta-N-acetylhexosaminidase.	hyaluronate	25-36	O-GlcNAcase	Homo sapiens	63-90
33932413-9	2021	Combined with CD44 receptor targeting ability of hyaluronate and the merits of nanogel, the catechol modified hyaluronate nanogel exhibited as an efficient chemotherapeutic formulation of BTZ for cancer treatment.	hyaluronate	110-121	CD44 molecule (Indian blood group)	Homo sapiens	14-18
4349508-0	1973	Hyaluronate inhibition of chondrogenesis: antagonism of thyroxine, growth hormone, and calcitonin.	hyaluronate	0-11	growth hormone	Gallus gallus	67-81
4349508-2	1973	Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3",5"-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.	hyaluronate	125-136	growth hormone	Gallus gallus	34-48
31341151-3	2019	CD44 is a major cell surface receptor for hyaluronate and is known as a cancer stem cell marker.	hyaluronate	42-53	CD44 molecule (Indian blood group)	Homo sapiens	0-4
33187133-3	2020	These dots thus prepared ( 10 nm in diameter) enabled extensive cellular interactions such as hyaluronate (HA)-mediated CD44 receptor binding, ALN-mediated bone targeting, and cRGD-mediated tumor integrin alphavbeta3 binding, thus improving their tumor targeting efficiency, especially for metastasized MDA-MB-231 tumors.	hyaluronate	94-105	CD44 molecule (Indian blood group)	Homo sapiens	120-124
32941896-0	2020	Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression.	hyaluronate	40-51	interleukin 6	Mus musculus	27-30
32944844-0	2020	Codelivery of HIF-1alpha siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression.	hyaluronate	96-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
31502433-3	2019	Here, we developed a hyaluronate-gold nanoparticle/glucose oxidase (HA-AuNP/GOx) complex and an ultralow-power application-specific integrated circuit chip for noninvasive and robust wireless patch-type glucose sensors.	hyaluronate	21-32	hydroxyacid oxidase 1	Homo sapiens	76-79
29087002-2	2018	The fine distribution of hyaluronate in the regenerating tail blastemas has been assessed by ultrastructural immunolocalization of the Hyaluronate Binding Protein (HABP), a protein that indirectly reveals the presence of hyaluronate in tissues.	hyaluronate	25-36	TNF alpha induced protein 6	Homo sapiens	135-162
29616250-2	2018	Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells.	hyaluronate	54-65	epidermal growth factor	Homo sapiens	6-29
29616250-2	2018	Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells.	hyaluronate	54-65	epidermal growth factor	Homo sapiens	31-34
29087002-2	2018	The fine distribution of hyaluronate in the regenerating tail blastemas has been assessed by ultrastructural immunolocalization of the Hyaluronate Binding Protein (HABP), a protein that indirectly reveals the presence of hyaluronate in tissues.	hyaluronate	25-36	TNF alpha induced protein 6	Homo sapiens	164-168
29087002-2	2018	The fine distribution of hyaluronate in the regenerating tail blastemas has been assessed by ultrastructural immunolocalization of the Hyaluronate Binding Protein (HABP), a protein that indirectly reveals the presence of hyaluronate in tissues.	hyaluronate	221-232	TNF alpha induced protein 6	Homo sapiens	135-162
29087002-2	2018	The fine distribution of hyaluronate in the regenerating tail blastemas has been assessed by ultrastructural immunolocalization of the Hyaluronate Binding Protein (HABP), a protein that indirectly reveals the presence of hyaluronate in tissues.	hyaluronate	221-232	TNF alpha induced protein 6	Homo sapiens	164-168
29087002-4	2018	HABP appears, therefore, accumulated along the cell surface, indicating that hyaluronate coats these embryonic-like cells and their antigens.	hyaluronate	77-88	TNF alpha induced protein 6	Homo sapiens	0-4
29203426-11	2018	To confirm the wound healing capacity of newly developed materials (ST-EGF and ST-bFGF-loaded hyaluronate-collagen dressing [HCD] matrix), we applied these matrices in type I and type II diabetic wounds.	hyaluronate	94-105	fibroblast growth factor 2	Mus musculus	82-86