PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25640585-5	2015	For all synthesized compounds, the highest HtrA2-mediated hydrolysis efficiency and selectivity among tested HtrA family members was observed for ABZ-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2, which displayed a specificity constant kcat/KM value of 14,535M(-1)s(-1).	3-no2	182-187	HtrA serine peptidase 2	Homo sapiens	43-48
9448842-5	1998	For example, the substrate o-aminobenzoyl-Tbg-Tbg-Asn (NMe2)-Ala decreases Ser-Ser-Arg-Leu-Tyr(3-NO2)Arg-OH (2) displayed a kcat/K(m) value of 15,940 M-1 s-1 i.e., more than 60-fold greater than that of the equivalent, nonoptimized substrate 1 under identical conditions.	3-no2	95-100	serpin family A member 7	Homo sapiens	42-45
9448842-5	1998	For example, the substrate o-aminobenzoyl-Tbg-Tbg-Asn (NMe2)-Ala decreases Ser-Ser-Arg-Leu-Tyr(3-NO2)Arg-OH (2) displayed a kcat/K(m) value of 15,940 M-1 s-1 i.e., more than 60-fold greater than that of the equivalent, nonoptimized substrate 1 under identical conditions.	3-no2	95-100	serpin family A member 7	Homo sapiens	46-49
9448842-5	1998	For example, the substrate o-aminobenzoyl-Tbg-Tbg-Asn (NMe2)-Ala decreases Ser-Ser-Arg-Leu-Tyr(3-NO2)Arg-OH (2) displayed a kcat/K(m) value of 15,940 M-1 s-1 i.e., more than 60-fold greater than that of the equivalent, nonoptimized substrate 1 under identical conditions.	3-no2	95-100	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	55-59
2995954-1	1985	New syntheses of three thyrotropin releasing hormone (TRH) analogues ([Dopa2]THR, [Nic1]TRH, and [Tyr(30NO2)2]TRH) have been reported (Dopa stands for L-3,4-dihydroxyphenylalanine, Nic--for nicotinic acid and Tyr(3-NO2)--for L-3-nitrotyrosine).	3-no2	213-218	thyrotropin releasing hormone	Rattus norvegicus	23-52
2995954-1	1985	New syntheses of three thyrotropin releasing hormone (TRH) analogues ([Dopa2]THR, [Nic1]TRH, and [Tyr(30NO2)2]TRH) have been reported (Dopa stands for L-3,4-dihydroxyphenylalanine, Nic--for nicotinic acid and Tyr(3-NO2)--for L-3-nitrotyrosine).	3-no2	213-218	thyrotropin releasing hormone	Rattus norvegicus	54-57
24161741-5	2014	The iterative deconvolution of two libraries to define the specificity of matriptase-2 yielded to the identification of the substrate ABZ-Ile-Arg-Ala-Arg-Ser-Ala-Gly-Tyr(3-NO2)-NH2 with a k(cat)/K(m) value of 4.5 x 10(5) M(-1) x s(-1), i.e. the highest specificity constant reported so far for matriptase-2.	3-no2	170-175	transmembrane serine protease 6	Homo sapiens	74-86
25151941-1	2014	Internally quenched cathepsin L (Cat L) substrate ABZ-Bip-Arg-Ala-Gln-Tyr(3-NO2)-NH2 with high specificity constant (kcat/KM=2.6x10(7)M(-1)s(-1)) was synthesized.	3-no2	74-79	cathepsin L	Homo sapiens	20-31
25151941-1	2014	Internally quenched cathepsin L (Cat L) substrate ABZ-Bip-Arg-Ala-Gln-Tyr(3-NO2)-NH2 with high specificity constant (kcat/KM=2.6x10(7)M(-1)s(-1)) was synthesized.	3-no2	74-79	cathepsin L	Homo sapiens	33-38
25151941-1	2014	Internally quenched cathepsin L (Cat L) substrate ABZ-Bip-Arg-Ala-Gln-Tyr(3-NO2)-NH2 with high specificity constant (kcat/KM=2.6x10(7)M(-1)s(-1)) was synthesized.	3-no2	74-79	heat shock protein family A (Hsp70) member 5	Homo sapiens	54-57
25640585-5	2015	For all synthesized compounds, the highest HtrA2-mediated hydrolysis efficiency and selectivity among tested HtrA family members was observed for ABZ-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2, which displayed a specificity constant kcat/KM value of 14,535M(-1)s(-1).	3-no2	182-187	HtrA serine peptidase 1	Homo sapiens	43-47
24161741-5	2014	The iterative deconvolution of two libraries to define the specificity of matriptase-2 yielded to the identification of the substrate ABZ-Ile-Arg-Ala-Arg-Ser-Ala-Gly-Tyr(3-NO2)-NH2 with a k(cat)/K(m) value of 4.5 x 10(5) M(-1) x s(-1), i.e. the highest specificity constant reported so far for matriptase-2.	3-no2	170-175	transmembrane serine protease 6	Homo sapiens	294-306
23911525-3	2013	The iterative deconvolution of such a library allowed us to obtain the sequence ABZ-Tyr-Tyr-Abu-Asn-Glu-Pro-Tyr(3-NO2)-NH2 with a high specificity constant (kcat/KM=1534x10(3)M(-1)s(-1)) and superior selectivity over neutrophil elastase and other neutrophil-derived serine proteases.	3-no2	112-117	elastase, neutrophil expressed	Homo sapiens	217-236