PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12458962-2	2002	In 1985, N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was designed as a selective enzyme-activated irreversible inhibitor of polyamine oxidase (EC 1.5.3.11).	MDL 72527	54-63	polyamine oxidase	Homo sapiens	136-153
17088995-6	2006	MDL 72527, an inhibitor of polyamine oxidase, an enzyme of the polyamine catabolic pathway, potentiated the antiproliferative effects of 7beta-OHcholesterol by increasing the N1-acetylspermidine pool and enhanced the accumulation of apoptotic cells.	MDL 72527	0-9	polyamine oxidase	Homo sapiens	27-44
11739609-5	2001	Treatment of cultures with N1,N(2)-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527), an irreversible inhibitor of polyamine oxidase, resulted in a partial but significant neuronal protection, especially in CA1 region.	MDL 72527	74-83	polyamine oxidase	Homo sapiens	115-132
10519408-2	1999	Inhibition of polyamine oxidase in hematopoietic cells by a specific inhibitor, N,N"-bis(2,3-butadienyl)-1,4-butanediamine (MDL-72,527), reduces the levels of Put and Spd and induces the accumulation of N1-acetylated Spd.	MDL 72527	80-122	polyamine oxidase	Homo sapiens	14-31
10880565-12	2000	In contrast, the combination of N(1), N(11)-diethylnorspermine with MDL72527 dramatically activated SSAT, causing profound depletion of pancreatic polyamines and acute pancreatitis.	MDL 72527	68-76	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	100-104
10320741-2	1999	Pretreatment with the polyamine oxidase inhibitor MDL72527 caused an accumulation of N1-acetylspermidine and N1-acetylspermine in normal rats.	MDL 72527	50-58	polyamine oxidase	Rattus norvegicus	22-39
9486183-3	1998	A polyamine oxidase inhibitor, N,N"-bis(2,3-butadienyl)-1,4-butanediamine (MDL-72527), but not an ODC inhibitor, alpha-difluoromethylornithine (DFMO), inhibited the increases in putrescine level and DNA synthesis at 5 h. The inhibition of DNA synthesis by MDL-72527 was reversed by putrescine administration.	MDL 72527	31-73	polyamine oxidase	Rattus norvegicus	2-19
10368296-6	1999	The structure of PAO in complex with the inhibitor MDL72527 reveals the residues forming the catalytic machinery and unusual enzyme-inhibitor CH.O H bonds.	MDL 72527	51-59	polyamine oxidase 1	Zea mays	17-20
9326648-6	1997	Important to note, specific inhibition of PAO by N,N"-bis(2, 3-butadienyl)-1,4-butane-diamine results in a significant reduction of the formation of HMW DNA and nuclear fragmentation.	MDL 72527	49-93	polyamine oxidase	Homo sapiens	42-45
7554238-2	1995	Pretreatment of 7-day-old rats with the polyamine oxidase inhibitor, MDL 72527, induced a similar accumulation of N-acetylspermidine and N-acetylspermine in control and kainate-treated animals.	MDL 72527	69-78	polyamine oxidase	Rattus norvegicus	40-57
8832742-2	1996	MDL 72527, the specific inhibitor of mammalian polyamine oxidase, had no effect on the Ascaris suum enzyme, whereas its activity was inhibited in a time-dependent manner by the haloallylamine MDL 72145, originally designed as a specific inhibitor of monoamine oxidase A and B.	MDL 72527	0-9	polyamine oxidase	Homo sapiens	47-64
8689922-6	1996	Spermine was not metabolized in cytotoxic products: rat pretreatment with MDL72527 (an inhibitor of polyamine oxidase) did not avoid the decrease in disaccharidase activity and in DNA and protein content.	MDL 72527	74-82	polyamine oxidase	Rattus norvegicus	100-117
8243835-3	1993	Simultaneous administration of DFMO and MDL-72527 resulted in a significant inhibition of the camostate-induced increases in pancreatic putrescine, ODC and DNA over 5 days, while the initial significant inhibition of pancreatic weight, protein content, DNA-polymerase and especially spermidine was absent after 5 days and spermine as well as N1-acetylspermidine were even increased.	MDL 72527	40-49	ornithine decarboxylase 1	Rattus norvegicus	148-151
8119700-5	1994	Treatment of the animals with N1,N2-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527), a specific inhibitor of polyamine oxidase, caused large accumulation of N1-acetylspermidine in hepatoma cells and in the ascitic fluid; the maximal values were reached at day 14.	MDL 72527	76-85	polyamine oxidase	Rattus norvegicus	112-129
8243835-2	1993	Furthermore it was investigated whether the simultaneous inhibition of the polyamine interconversion pathway by the potent polyamine oxidase inhibitor MDL-72527 together with the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO) is able to enhance and prolong the only initial and transient inhibitory effects of DFMO on camostate-induced pancreatic growth.	MDL 72527	151-160	polyamine oxidase	Rattus norvegicus	123-140
2065821-2	1991	Treatment of mice and rats with the polyamine oxidase inhibitor N1,N4-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527) causes a gradual accumulation of spermine in the circulation and a decrease of spermidine concentration.	MDL 72527	110-119	polyamine oxidase	Rattus norvegicus	36-53
35458639-7	2022	Comparison with a reference SMOX inhibitor MDL72527 showed nine-fold better activity for the best performing HPG analog.	MDL 72527	43-51	spermine oxidase	Homo sapiens	28-32
2128509-3	1990	For this purpose, the urinary metabolic pattern of oral 14C-milacemide was determined in rats with and without pretreatment with the irreversible PAO inhibitor MDL 72527 and, for comparison, after inhibition of MAO-B by l-deprenyl.	MDL 72527	160-169	polyamine oxidase	Rattus norvegicus	146-149
35216248-5	2022	Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206.	MDL 72527	212-221	CD68 antigen	Mus musculus	126-157
35216248-5	2022	Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206.	MDL 72527	212-221	arginase, liver	Mus musculus	312-321
35216248-5	2022	Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206.	MDL 72527	212-221	mannose receptor, C type 1	Mus musculus	326-331
31991839-6	2020	Utilizing the streptozotocin-induced mouse model of diabetes, the impact of the SMOX inhibitor, MDL 72527, on neuronal damage and dysfunction in the diabetic retina was investigated.	MDL 72527	96-105	spermine oxidase	Mus musculus	80-84
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	MDL 72527	201-209	granzyme F	Mus musculus	69-74
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	MDL 72527	201-209	polyamine oxidase (exo-N4-amino)	Mus musculus	116-120
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	MDL 72527	201-209	spermine oxidase	Mus musculus	125-129
27239699-5	2016	New-born C57BL6/J mice were exposed to hyperoxia (70% O2) from postnatal day (P) 7 to 12 and were treated with the polyamine oxidase inhibitor MDL 72527 or vehicle starting at P6.	MDL 72527	143-152	polyamine oxidase	Rattus norvegicus	115-132
3923382-1	1985	N1,N2-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527) is an irreversible, specific inhibitor of polyamine oxidase, which allows one to completely inactivate this enzyme in all organs of an experimental animal.	MDL 72527	46-55	polyamine oxidase	Homo sapiens	99-116
32579679-11	2020	Generation of FDP-Lys and hydrogen peroxide increased in TR-MUL5 cells under hypoxic condition, which was abrogated by SMOX inhibitor MDL72527.	MDL 72527	134-142	spermine oxidase	Rattus norvegicus	119-123