PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12458962-2 2002 In 1985, N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was designed as a selective enzyme-activated irreversible inhibitor of polyamine oxidase (EC 1.5.3.11). MDL 72527 54-63 polyamine oxidase Homo sapiens 136-153 17088995-6 2006 MDL 72527, an inhibitor of polyamine oxidase, an enzyme of the polyamine catabolic pathway, potentiated the antiproliferative effects of 7beta-OHcholesterol by increasing the N1-acetylspermidine pool and enhanced the accumulation of apoptotic cells. MDL 72527 0-9 polyamine oxidase Homo sapiens 27-44 11739609-5 2001 Treatment of cultures with N1,N(2)-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527), an irreversible inhibitor of polyamine oxidase, resulted in a partial but significant neuronal protection, especially in CA1 region. MDL 72527 74-83 polyamine oxidase Homo sapiens 115-132 10519408-2 1999 Inhibition of polyamine oxidase in hematopoietic cells by a specific inhibitor, N,N"-bis(2,3-butadienyl)-1,4-butanediamine (MDL-72,527), reduces the levels of Put and Spd and induces the accumulation of N1-acetylated Spd. MDL 72527 80-122 polyamine oxidase Homo sapiens 14-31 10880565-12 2000 In contrast, the combination of N(1), N(11)-diethylnorspermine with MDL72527 dramatically activated SSAT, causing profound depletion of pancreatic polyamines and acute pancreatitis. MDL 72527 68-76 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 100-104 10320741-2 1999 Pretreatment with the polyamine oxidase inhibitor MDL72527 caused an accumulation of N1-acetylspermidine and N1-acetylspermine in normal rats. MDL 72527 50-58 polyamine oxidase Rattus norvegicus 22-39 9486183-3 1998 A polyamine oxidase inhibitor, N,N"-bis(2,3-butadienyl)-1,4-butanediamine (MDL-72527), but not an ODC inhibitor, alpha-difluoromethylornithine (DFMO), inhibited the increases in putrescine level and DNA synthesis at 5 h. The inhibition of DNA synthesis by MDL-72527 was reversed by putrescine administration. MDL 72527 31-73 polyamine oxidase Rattus norvegicus 2-19 10368296-6 1999 The structure of PAO in complex with the inhibitor MDL72527 reveals the residues forming the catalytic machinery and unusual enzyme-inhibitor CH.O H bonds. MDL 72527 51-59 polyamine oxidase 1 Zea mays 17-20 9326648-6 1997 Important to note, specific inhibition of PAO by N,N"-bis(2, 3-butadienyl)-1,4-butane-diamine results in a significant reduction of the formation of HMW DNA and nuclear fragmentation. MDL 72527 49-93 polyamine oxidase Homo sapiens 42-45 7554238-2 1995 Pretreatment of 7-day-old rats with the polyamine oxidase inhibitor, MDL 72527, induced a similar accumulation of N-acetylspermidine and N-acetylspermine in control and kainate-treated animals. MDL 72527 69-78 polyamine oxidase Rattus norvegicus 40-57 8832742-2 1996 MDL 72527, the specific inhibitor of mammalian polyamine oxidase, had no effect on the Ascaris suum enzyme, whereas its activity was inhibited in a time-dependent manner by the haloallylamine MDL 72145, originally designed as a specific inhibitor of monoamine oxidase A and B. MDL 72527 0-9 polyamine oxidase Homo sapiens 47-64 8689922-6 1996 Spermine was not metabolized in cytotoxic products: rat pretreatment with MDL72527 (an inhibitor of polyamine oxidase) did not avoid the decrease in disaccharidase activity and in DNA and protein content. MDL 72527 74-82 polyamine oxidase Rattus norvegicus 100-117 8243835-3 1993 Simultaneous administration of DFMO and MDL-72527 resulted in a significant inhibition of the camostate-induced increases in pancreatic putrescine, ODC and DNA over 5 days, while the initial significant inhibition of pancreatic weight, protein content, DNA-polymerase and especially spermidine was absent after 5 days and spermine as well as N1-acetylspermidine were even increased. MDL 72527 40-49 ornithine decarboxylase 1 Rattus norvegicus 148-151 8119700-5 1994 Treatment of the animals with N1,N2-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527), a specific inhibitor of polyamine oxidase, caused large accumulation of N1-acetylspermidine in hepatoma cells and in the ascitic fluid; the maximal values were reached at day 14. MDL 72527 76-85 polyamine oxidase Rattus norvegicus 112-129 8243835-2 1993 Furthermore it was investigated whether the simultaneous inhibition of the polyamine interconversion pathway by the potent polyamine oxidase inhibitor MDL-72527 together with the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO) is able to enhance and prolong the only initial and transient inhibitory effects of DFMO on camostate-induced pancreatic growth. MDL 72527 151-160 polyamine oxidase Rattus norvegicus 123-140 2065821-2 1991 Treatment of mice and rats with the polyamine oxidase inhibitor N1,N4-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527) causes a gradual accumulation of spermine in the circulation and a decrease of spermidine concentration. MDL 72527 110-119 polyamine oxidase Rattus norvegicus 36-53 35458639-7 2022 Comparison with a reference SMOX inhibitor MDL72527 showed nine-fold better activity for the best performing HPG analog. MDL 72527 43-51 spermine oxidase Homo sapiens 28-32 2128509-3 1990 For this purpose, the urinary metabolic pattern of oral 14C-milacemide was determined in rats with and without pretreatment with the irreversible PAO inhibitor MDL 72527 and, for comparison, after inhibition of MAO-B by l-deprenyl. MDL 72527 160-169 polyamine oxidase Rattus norvegicus 146-149 35216248-5 2022 Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206. MDL 72527 212-221 CD68 antigen Mus musculus 126-157 35216248-5 2022 Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206. MDL 72527 212-221 arginase, liver Mus musculus 312-321 35216248-5 2022 Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206. MDL 72527 212-221 mannose receptor, C type 1 Mus musculus 326-331 31991839-6 2020 Utilizing the streptozotocin-induced mouse model of diabetes, the impact of the SMOX inhibitor, MDL 72527, on neuronal damage and dysfunction in the diabetic retina was investigated. MDL 72527 96-105 spermine oxidase Mus musculus 80-84 29477597-2 2018 N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes. MDL 72527 201-209 granzyme F Mus musculus 69-74 29477597-2 2018 N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes. MDL 72527 201-209 polyamine oxidase (exo-N4-amino) Mus musculus 116-120 29477597-2 2018 N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes. MDL 72527 201-209 spermine oxidase Mus musculus 125-129 27239699-5 2016 New-born C57BL6/J mice were exposed to hyperoxia (70% O2) from postnatal day (P) 7 to 12 and were treated with the polyamine oxidase inhibitor MDL 72527 or vehicle starting at P6. MDL 72527 143-152 polyamine oxidase Rattus norvegicus 115-132 3923382-1 1985 N1,N2-bis-(2,3-butadienyl)-1,4-butanediamine (MDL 72527) is an irreversible, specific inhibitor of polyamine oxidase, which allows one to completely inactivate this enzyme in all organs of an experimental animal. MDL 72527 46-55 polyamine oxidase Homo sapiens 99-116 32579679-11 2020 Generation of FDP-Lys and hydrogen peroxide increased in TR-MUL5 cells under hypoxic condition, which was abrogated by SMOX inhibitor MDL72527. MDL 72527 134-142 spermine oxidase Rattus norvegicus 119-123