PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31460020-5 2019 TPP or HPCTP can generate active phosphorous species and phenoxyl radicals to enhance the gas phase flame-retardant effect; therefore, the flame-retarded PS foams (with 25 wt % MP/EG) achieve HF1 and V-0 ratings, with limiting oxygen index (LOI) values of 30.1 or 29.6%, respectively. triphenyl phosphate 0-3 complement factor H Homo sapiens 192-195 31724879-10 2019 One of the chemicals, TPHP, was able to promote the development of atherosclerotic lesions in the ApoE-/- mouse model. triphenyl phosphate 22-26 apolipoprotein E Mus musculus 98-102 31032947-6 2019 Additionally, DNA damage was detected in mESCs after a short-term treatment with TPHP, which in turn, activated DNA damage responses, leading to cell cycle arrest by changing the expression levels of p53, proliferating cell nuclear antigen, and Y15-phosphorylated Cdk I. triphenyl phosphate 81-85 tumor protein p53 Danio rerio 200-203 31032947-7 2019 Furthermore, our results revealed that short-term treatment with TPHP disturbed cardiac differentiation by decreasing the expression levels of Oct4, Sox2, and Nanog and transiently reduced the glycolysis capacity in mESCs. triphenyl phosphate 65-69 POU domain, class 5, transcription factor 3 Danio rerio 143-147 31032947-7 2019 Furthermore, our results revealed that short-term treatment with TPHP disturbed cardiac differentiation by decreasing the expression levels of Oct4, Sox2, and Nanog and transiently reduced the glycolysis capacity in mESCs. triphenyl phosphate 65-69 SRY-box transcription factor 2 Danio rerio 149-153 31032947-7 2019 Furthermore, our results revealed that short-term treatment with TPHP disturbed cardiac differentiation by decreasing the expression levels of Oct4, Sox2, and Nanog and transiently reduced the glycolysis capacity in mESCs. triphenyl phosphate 65-69 nanog homeobox Danio rerio 159-164 31268531-3 2019 Because hCE1 is critical for the activation of imidapril, an angiotensin-converting enzyme (ACE)-inhibitor prodrug prescribed to treat hypertension, the most potent inhibitors, TPHP and 4tBPDPP, and an environmentally relevant mixture (house dust) were further evaluated for their effect on imidapril bioactivation in vitro. triphenyl phosphate 177-181 carboxylesterase 1 Homo sapiens 8-12 31268531-4 2019 TPHP and 4tBPDPP were potent inhibitors of hCE1-mediated imidapril activation (Ki = 49.0 and 17.9 nM, respectively). triphenyl phosphate 0-4 carboxylesterase 1 Homo sapiens 43-47 31751126-1 2019 Since triphenyl phosphate (TPhP) elicits both anti-estrogenic activity via blocking estrogen receptor (ER) and estrogenic activity by elevating 17beta-estradiol (17beta-E2) synthesis, its adverse effects on female reproduction is uncertain. triphenyl phosphate 6-25 estrogen receptor Oryzias latipes 84-101 31751126-1 2019 Since triphenyl phosphate (TPhP) elicits both anti-estrogenic activity via blocking estrogen receptor (ER) and estrogenic activity by elevating 17beta-estradiol (17beta-E2) synthesis, its adverse effects on female reproduction is uncertain. triphenyl phosphate 6-25 estrogen receptor Oryzias latipes 103-105 31751126-1 2019 Since triphenyl phosphate (TPhP) elicits both anti-estrogenic activity via blocking estrogen receptor (ER) and estrogenic activity by elevating 17beta-estradiol (17beta-E2) synthesis, its adverse effects on female reproduction is uncertain. triphenyl phosphate 27-31 estrogen receptor Oryzias latipes 84-101 31751126-1 2019 Since triphenyl phosphate (TPhP) elicits both anti-estrogenic activity via blocking estrogen receptor (ER) and estrogenic activity by elevating 17beta-estradiol (17beta-E2) synthesis, its adverse effects on female reproduction is uncertain. triphenyl phosphate 27-31 estrogen receptor Oryzias latipes 103-105 31751126-5 2019 Considering 17beta-E2 was only significantly decreased in 1773 ng/L exposure group, ER antagonism could be the dominant contributor to the inhibition of vtg transcription and female reproductive toxicity of TPhP. triphenyl phosphate 207-211 estrogen receptor Oryzias latipes 84-86 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 49-68 peroxisome proliferator activated receptor gamma Mus musculus 190-199 30862559-7 2019 The number of CD8+IL-17 + cells was significantly correlated with the CSF RPR and CSF TPPA levels. triphenyl phosphate 86-90 CD8a molecule Homo sapiens 14-23 30421920-4 2018 Our in vitro study shows that TPHP is metabolized into its diester metabolite DPHP and mono- and dihydroxylated metabolites by cytochromes P450 (CYP) in human liver microsomes, while CYP1A2 and CYP2E1 isoforms are mainly involved in such processes. triphenyl phosphate 30-34 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 183-189 30421920-4 2018 Our in vitro study shows that TPHP is metabolized into its diester metabolite DPHP and mono- and dihydroxylated metabolites by cytochromes P450 (CYP) in human liver microsomes, while CYP1A2 and CYP2E1 isoforms are mainly involved in such processes. triphenyl phosphate 30-34 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 194-200 28595143-4 2017 Polybrominated diphenyl ether congener 209 (BDE 209) and decabromodiphenyl ethane (DBDPE) were the most abundant brominated flame retardants (BFRs), and tris(chloroisopropyl) phosphate (TCIPP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and triphenyl phosphate (TPHP) were the most abundant phosphate flame retardants (PFRs). triphenyl phosphate 246-265 homeobox D13 Homo sapiens 44-47 28595143-4 2017 Polybrominated diphenyl ether congener 209 (BDE 209) and decabromodiphenyl ethane (DBDPE) were the most abundant brominated flame retardants (BFRs), and tris(chloroisopropyl) phosphate (TCIPP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and triphenyl phosphate (TPHP) were the most abundant phosphate flame retardants (PFRs). triphenyl phosphate 267-271 homeobox D13 Homo sapiens 44-47 28934090-12 2017 Further, using global gene expression analysis we showed that both TPP and IPTP likely exert their effects through PPARG to induce adipogenesis. triphenyl phosphate 67-70 peroxisome proliferator activated receptor gamma Homo sapiens 115-120 30974155-7 2019 On the other hand, cells treated with TCEP and TPP showed opposite trends between cyp1a1 mRNA and enzymatic activities. triphenyl phosphate 47-50 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 82-88 30561715-8 2019 The expression of Sox9, the master regulator of chondrogenesis, was altered by BDE-47, TPHP, and BPDP. triphenyl phosphate 87-91 SRY (sex determining region Y)-box 9 Mus musculus 18-22 29529285-5 2018 As these data suggested that TPHP may be activating RXR (a heterodimer for both RARs and PPARgamma), we coexposed embryos to HX 531-a pan-RXR antagonist-from 24 to 72 hpf and, contrary to our hypothesis, found that coexposure to HX 531 significantly enhanced TPHP-induced cardiotoxicity. triphenyl phosphate 29-33 retinoid x receptor, gamma a Danio rerio 52-55 29529285-5 2018 As these data suggested that TPHP may be activating RXR (a heterodimer for both RARs and PPARgamma), we coexposed embryos to HX 531-a pan-RXR antagonist-from 24 to 72 hpf and, contrary to our hypothesis, found that coexposure to HX 531 significantly enhanced TPHP-induced cardiotoxicity. triphenyl phosphate 29-33 arginyl-tRNA synthetase 1 Danio rerio 80-84 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 peroxisome proliferator activated receptor gamma Homo sapiens 234-243 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 CCAAT enhancer binding protein alpha Homo sapiens 277-289 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 294-335 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 sterol regulatory element binding transcription factor 1 Homo sapiens 337-345 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 fatty acid binding protein 4 Homo sapiens 380-385 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 lipoprotein lipase Homo sapiens 386-389 28934090-9 2017 RESULTS: FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARgamma, CCAAT enhancer binding protein (C/EBP) alpha and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. triphenyl phosphate 15-34 perilipin 1 Homo sapiens 394-403 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 49-68 fatty acid binding protein 4, adipocyte Mus musculus 208-227 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 49-68 fatty acid binding protein 4, adipocyte Mus musculus 229-232 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 73-92 peroxisome proliferator activated receptor gamma Mus musculus 190-199 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 73-92 fatty acid binding protein 4, adipocyte Mus musculus 208-227 28437481-0 2017 Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter. triphenyl phosphate 73-92 fatty acid binding protein 4, adipocyte Mus musculus 229-232 28437481-2 2017 Animal and in vitro studies suggest that FM550, TPP and IPTP may have adipogenic effects and may exert these effects through PPARgamma activation. triphenyl phosphate 48-51 peroxisome proliferator activated receptor gamma Mus musculus 125-134 28437481-11 2017 Exposure to FM550, IPTP, and TPP significantly increased PPARgamma mediated aP2 enhancer activity. triphenyl phosphate 29-32 peroxisome proliferator activated receptor gamma Mus musculus 57-66 28437481-11 2017 Exposure to FM550, IPTP, and TPP significantly increased PPARgamma mediated aP2 enhancer activity. triphenyl phosphate 29-32 fatty acid binding protein 4, adipocyte Mus musculus 76-79 28437481-12 2017 Furthermore, we show that TPP- and IPTP-dependent upregulation of aP2 was significantly inhibited by the selective PPARgamma antagonist GW9662. triphenyl phosphate 26-29 fatty acid binding protein 4, adipocyte Mus musculus 66-69 28437481-12 2017 Furthermore, we show that TPP- and IPTP-dependent upregulation of aP2 was significantly inhibited by the selective PPARgamma antagonist GW9662. triphenyl phosphate 26-29 peroxisome proliferator activated receptor gamma Mus musculus 115-124 28437481-13 2017 In addition, chromatin immunoprecipitation experiments showed that IPTP and TPP treatment led to the recruitment of PPARgamma to the regulatory region of aP2. triphenyl phosphate 76-79 peroxisome proliferator activated receptor gamma Mus musculus 116-125 28437481-13 2017 In addition, chromatin immunoprecipitation experiments showed that IPTP and TPP treatment led to the recruitment of PPARgamma to the regulatory region of aP2. triphenyl phosphate 76-79 fatty acid binding protein 4, adipocyte Mus musculus 154-157 29492305-10 2017 Exposure to triphenyl phosphate was associated with hypermethylation at the GRB10 DMR; and tris(1,3-dichloro-2-propyl) phosphate exposure was associated with altered methylation at the MEG3 and H19 DMRs. triphenyl phosphate 12-31 growth factor receptor bound protein 10 Homo sapiens 76-81 26979758-5 2016 Triphenyl phosphate, tris(1,3-dichloro-2-propyl) phosphate, tris(butyl) phosphate, hexabromocyclododecane, and tetrabromobisphenol A showed statistically significant estrogenic activity, with hexabromocyclododecane being the most potent of the five (EC20 of 5.5 muM). triphenyl phosphate 0-19 latexin Homo sapiens 262-265 26183808-5 2015 In addition, the hepatic activities of antioxidant enzymes including glutathione peroxidase (GPX), catalase (CAT) and glutathione S-transferase (GST) as well as their related gene expression were affected by TPP or TECP exposure. triphenyl phosphate 208-211 catalase Mus musculus 99-107 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 estrogen receptor 2 Homo sapiens 61-67 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 nuclear receptor subfamily 1 group I member 2 Homo sapiens 129-148 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 nuclear receptor subfamily 1 group I member 2 Homo sapiens 150-153 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 androgen receptor Homo sapiens 185-202 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 androgen receptor Homo sapiens 204-206 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 nuclear receptor subfamily 3 group C member 1 Homo sapiens 212-235 26778350-5 2016 In addition, these hydroxylated TPHP-metabolites also showed ERbeta antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. triphenyl phosphate 32-36 nuclear receptor subfamily 3 group C member 1 Homo sapiens 237-239 26049154-3 2015 Significant increases in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione S-transferase (GST) activities and their respective gene expressions in a dose-dependent and/or time-dependent manner in TPP or TCEP groups. triphenyl phosphate 235-238 hematopoietic prostaglandin D synthase Mus musculus 129-132 26049154-6 2015 Furthermore, co-treatments of hCG with TPP or TCEP could inhibit hCG-induced changes in the expression of P450scc, P450-17alpha and 17beta-HSD and T levels. triphenyl phosphate 39-42 cytochrome P450, family 11, subfamily a, polypeptide 1 Mus musculus 106-113 26049154-6 2015 Furthermore, co-treatments of hCG with TPP or TCEP could inhibit hCG-induced changes in the expression of P450scc, P450-17alpha and 17beta-HSD and T levels. triphenyl phosphate 39-42 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 132-142 26183808-5 2015 In addition, the hepatic activities of antioxidant enzymes including glutathione peroxidase (GPX), catalase (CAT) and glutathione S-transferase (GST) as well as their related gene expression were affected by TPP or TECP exposure. triphenyl phosphate 208-211 catalase Mus musculus 109-112 26183808-5 2015 In addition, the hepatic activities of antioxidant enzymes including glutathione peroxidase (GPX), catalase (CAT) and glutathione S-transferase (GST) as well as their related gene expression were affected by TPP or TECP exposure. triphenyl phosphate 208-211 hematopoietic prostaglandin D synthase Mus musculus 118-143 26183808-5 2015 In addition, the hepatic activities of antioxidant enzymes including glutathione peroxidase (GPX), catalase (CAT) and glutathione S-transferase (GST) as well as their related gene expression were affected by TPP or TECP exposure. triphenyl phosphate 208-211 hematopoietic prostaglandin D synthase Mus musculus 145-148 34890987-4 2022 The results showed that TPhP acted as an ERalpha agonist and recruited steroid receptor co-activator 1 (SRC1) and 3 (SRC3), which was found for the first time. triphenyl phosphate 24-28 estrogen receptor 1 Homo sapiens 41-48 25725299-1 2015 Using zebrafish as a model, we previously reported that developmental exposure to triphenyl phosphate (TPP) - a high-production volume organophosphate-based flame retardant - results in dioxin-like cardiac looping impairments that are independent of the aryl hydrocarbon receptor. triphenyl phosphate 82-101 aryl hydrocarbon receptor 1a Danio rerio 254-279 25725299-1 2015 Using zebrafish as a model, we previously reported that developmental exposure to triphenyl phosphate (TPP) - a high-production volume organophosphate-based flame retardant - results in dioxin-like cardiac looping impairments that are independent of the aryl hydrocarbon receptor. triphenyl phosphate 103-106 aryl hydrocarbon receptor 1a Danio rerio 254-279 25725299-5 2015 Using real-time PCR, we then quantified the relative change in expression of cytochrome P450 26a1 (cyp26a1) - a major target gene for RA-induced RAR activation in zebrafish - and found that RA and TPP exposure resulted in a ~5-fold increase and decrease in cyp26a1 expression, respectively, relative to vehicle-exposed embryos. triphenyl phosphate 197-200 cytochrome P450, family 26, subfamily A, polypeptide 1 Danio rerio 77-97 25725299-5 2015 Using real-time PCR, we then quantified the relative change in expression of cytochrome P450 26a1 (cyp26a1) - a major target gene for RA-induced RAR activation in zebrafish - and found that RA and TPP exposure resulted in a ~5-fold increase and decrease in cyp26a1 expression, respectively, relative to vehicle-exposed embryos. triphenyl phosphate 197-200 cytochrome P450, family 26, subfamily A, polypeptide 1 Danio rerio 99-106 25725299-5 2015 Using real-time PCR, we then quantified the relative change in expression of cytochrome P450 26a1 (cyp26a1) - a major target gene for RA-induced RAR activation in zebrafish - and found that RA and TPP exposure resulted in a ~5-fold increase and decrease in cyp26a1 expression, respectively, relative to vehicle-exposed embryos. triphenyl phosphate 197-200 cytochrome P450, family 26, subfamily A, polypeptide 1 Danio rerio 257-264 25725299-7 2015 Overall, our findings suggest that zebrafish RARs may be involved in mediating TPP-induced developmental toxicity, a mechanism of action that may have relevance to humans. triphenyl phosphate 79-82 arginyl-tRNA synthetase 1 Danio rerio 45-49 14667932-7 2004 Among steroid hormone receptors, the human androgen receptor was inhibited by triphenyl phosphate and di-ortho-isopropylated phenyl phosphate (40-50%) and activated by di- and tri-para-substituted phenyl phosphates (2-fold). triphenyl phosphate 78-97 androgen receptor Homo sapiens 43-60 34627810-0 2022 In vitro biotransformation of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate by mouse liver microsomes: Kinetics and key CYP isoforms. triphenyl phosphate 72-91 peptidyl-prolyl isomerase G (cyclophilin G) Mus musculus 136-139 25646720-4 2015 In the GH3 cells, TPP up-regulated the expression of the tshbeta, tralpha, and trbeta genes, while T3, a positive control, down-regulated the expression of these genes. triphenyl phosphate 18-21 thyroid hormone receptor beta Rattus norvegicus 79-85 25062436-6 2014 Solvent mapping was used to model TPP in the PPARgamma binding site. triphenyl phosphate 34-37 peroxisome proliferator activated receptor gamma Homo sapiens 45-54 25062436-9 2014 RESULTS: FM550 bound human PPARgamma, and binding appeared to be driven primarily by TPP. triphenyl phosphate 85-88 peroxisome proliferator activated receptor gamma Homo sapiens 27-36 25062436-10 2014 Solvent mapping revealed that TPP interacted with binding hot spots within the PPARgamma ligand binding domain. triphenyl phosphate 30-33 peroxisome proliferator activated receptor gamma Homo sapiens 79-88 24051214-3 2013 Of the 11 OPFRs tested, triphenyl phosphate (TPhP) and tricrecyl phosphate (TCP) showed ERalpha and/or ERbeta agonistic activity. triphenyl phosphate 24-43 estrogen receptor 1 Homo sapiens 88-95 24051214-3 2013 Of the 11 OPFRs tested, triphenyl phosphate (TPhP) and tricrecyl phosphate (TCP) showed ERalpha and/or ERbeta agonistic activity. triphenyl phosphate 24-43 estrogen receptor 2 Homo sapiens 103-109 24051214-3 2013 Of the 11 OPFRs tested, triphenyl phosphate (TPhP) and tricrecyl phosphate (TCP) showed ERalpha and/or ERbeta agonistic activity. triphenyl phosphate 45-49 estrogen receptor 1 Homo sapiens 88-95 24051214-3 2013 Of the 11 OPFRs tested, triphenyl phosphate (TPhP) and tricrecyl phosphate (TCP) showed ERalpha and/or ERbeta agonistic activity. triphenyl phosphate 45-49 estrogen receptor 2 Homo sapiens 103-109 23603146-4 2013 After 21 d of exposure to TDCPP or TPP, significant decrease in fecundity along with significant increases of plasma 17beta-estradiol (E2) concentrations, vitellogenin (VTG) levels, and E2/testosterone (T) and E2/11-ketotestosterone (11-KT) ratios were observed. triphenyl phosphate 35-38 vitellogenin Danio rerio 155-167 23603146-4 2013 After 21 d of exposure to TDCPP or TPP, significant decrease in fecundity along with significant increases of plasma 17beta-estradiol (E2) concentrations, vitellogenin (VTG) levels, and E2/testosterone (T) and E2/11-ketotestosterone (11-KT) ratios were observed. triphenyl phosphate 35-38 vitellogenin Danio rerio 169-172 23306105-10 2013 The PPARalpha- and TRalpha-centered gene networks might be the primary pathways affected by TPP. triphenyl phosphate 92-95 peroxisome proliferator-activated receptor alpha b Danio rerio 4-13 23306105-10 2013 The PPARalpha- and TRalpha-centered gene networks might be the primary pathways affected by TPP. triphenyl phosphate 92-95 thyroid hormone receptor alpha a Danio rerio 19-26 17421051-9 2007 Activity of AChE, CarE or GST could be strongly inhibited, in vivo, by PB, TPP or DEM, depending on the insect species and enzyme inhibitors. triphenyl phosphate 75-78 glutathione S-transferase kappa 1 Homo sapiens 26-29 20693065-6 1994 TPP led to a concentration-dependent suppression of macrophage TNF activity as well as NK activity of spleen cells. triphenyl phosphate 0-3 tumor necrosis factor Mus musculus 63-66 34562708-6 2022 Nano-TiO2 also exacerbated the TPhP-induced inhibition of the axonal growth on the secondary motor neuron, and aggravated the TPhP-induced decrease on expressions of neuron-specific green fluorescent protein (GFP) and neuronal marker genes (ngn1 and elavl3). triphenyl phosphate 31-35 neurogenin 1 Danio rerio 241-245 34562708-6 2022 Nano-TiO2 also exacerbated the TPhP-induced inhibition of the axonal growth on the secondary motor neuron, and aggravated the TPhP-induced decrease on expressions of neuron-specific green fluorescent protein (GFP) and neuronal marker genes (ngn1 and elavl3). triphenyl phosphate 31-35 ELAV like neuron-specific RNA binding protein 3 Danio rerio 250-256 34562708-6 2022 Nano-TiO2 also exacerbated the TPhP-induced inhibition of the axonal growth on the secondary motor neuron, and aggravated the TPhP-induced decrease on expressions of neuron-specific green fluorescent protein (GFP) and neuronal marker genes (ngn1 and elavl3). triphenyl phosphate 126-130 neurogenin 1 Danio rerio 241-245 34562708-6 2022 Nano-TiO2 also exacerbated the TPhP-induced inhibition of the axonal growth on the secondary motor neuron, and aggravated the TPhP-induced decrease on expressions of neuron-specific green fluorescent protein (GFP) and neuronal marker genes (ngn1 and elavl3). triphenyl phosphate 126-130 ELAV like neuron-specific RNA binding protein 3 Danio rerio 250-256 34890987-4 2022 The results showed that TPhP acted as an ERalpha agonist and recruited steroid receptor co-activator 1 (SRC1) and 3 (SRC3), which was found for the first time. triphenyl phosphate 24-28 nuclear receptor coactivator 1 Homo sapiens 71-102 34890987-4 2022 The results showed that TPhP acted as an ERalpha agonist and recruited steroid receptor co-activator 1 (SRC1) and 3 (SRC3), which was found for the first time. triphenyl phosphate 24-28 nuclear receptor coactivator 1 Homo sapiens 104-108 34890987-4 2022 The results showed that TPhP acted as an ERalpha agonist and recruited steroid receptor co-activator 1 (SRC1) and 3 (SRC3), which was found for the first time. triphenyl phosphate 24-28 nuclear receptor coactivator 3 Homo sapiens 117-121 34890987-6 2022 However, both TPhP and TDCIPP activated the estrogen pathway by GPER in SKBR3 cells which were lack of ERalpha. triphenyl phosphate 14-18 G protein-coupled estrogen receptor 1 Homo sapiens 64-68 34890987-7 2022 Although molecular docking results revealed that both TPhP and TDCIPP could dock into ERalpha and GPER, their substituent groups and combination mode might affect the receptor activation. triphenyl phosphate 54-58 estrogen receptor 1 Homo sapiens 86-93 34890987-7 2022 Although molecular docking results revealed that both TPhP and TDCIPP could dock into ERalpha and GPER, their substituent groups and combination mode might affect the receptor activation. triphenyl phosphate 54-58 G protein-coupled estrogen receptor 1 Homo sapiens 98-102 34358932-12 2021 AR, mTOR and DDIT3 in the PC-3 and LNCap cells were significantly upregulated with 10-6 M TPP treated. triphenyl phosphate 90-93 mechanistic target of rapamycin kinase Homo sapiens 4-8 34843233-8 2021 Among environmental compounds, several molecules activated the PPARgamma of the four species similarly, e.g., phthalates (MEHP), perfluorinated compounds (PFOA, PFOS), and halogenated derivatives of BPA (TBBPA, TCBPA), but some of them like diclofenac and the organophosphorus compounds tri-o-tolyl phosphate and triphenyl phosphate were most active on zfPPARgamma. triphenyl phosphate 313-332 peroxisome proliferator activated receptor gamma Homo sapiens 63-72 34488164-0 2021 Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist. triphenyl phosphate 0-19 estrogen receptor 1 (alpha) Mus musculus 97-114 34488164-4 2021 An estrogen-responsive reporter transgenic mice assay demonstrated that TPhP significantly downregulated the estrogen receptor (ER) signaling by 45.1% in the whole body in the 50 mg/kg group, and by 14.7-43.7% in the uterus for all exposure groups compared with the control. triphenyl phosphate 72-76 estrogen receptor 1 (alpha) Mus musculus 109-126 34488164-4 2021 An estrogen-responsive reporter transgenic mice assay demonstrated that TPhP significantly downregulated the estrogen receptor (ER) signaling by 45.1% in the whole body in the 50 mg/kg group, and by 14.7-43.7% in the uterus for all exposure groups compared with the control. triphenyl phosphate 72-76 estrogen receptor 1 (alpha) Mus musculus 128-130 34488164-5 2021 This strong antagonistic activity of TPhP toward ER explained the delay in pubertal timing. triphenyl phosphate 37-41 estrogen receptor 1 (alpha) Mus musculus 49-51 34488164-7 2021 The elevation of the follicle-stimulating hormone concentration may have contributed to this phenomenon, as controlled by the antagonistic activity of TPhP toward ER in the brain. triphenyl phosphate 151-155 estrogen receptor 1 (alpha) Mus musculus 163-165 34358932-12 2021 AR, mTOR and DDIT3 in the PC-3 and LNCap cells were significantly upregulated with 10-6 M TPP treated. triphenyl phosphate 90-93 DNA damage inducible transcript 3 Homo sapiens 13-18 35612000-3 2022 Herein, through a simple solvothermal synthesis method, TpPa-1-COF, a typical 2D COF, which displays a wide light absorption region, is rationally combined with transition metal phosphides (TMPs) to fabricate three TMPs/TpPa-1-COF hybrid materials, named Ni12 P5 (Ni2 P or CoP)/TpPa-1-COF. triphenyl phosphate 278-282 caspase recruitment domain family member 16 Homo sapiens 273-276 34323617-11 2021 3T3-L1 cells treated with two known environmental PPARgamma ligands, tetrabromobisphenol A and triphenyl phosphate, which sorted distinctly from therapeutic ligands, had higher expression of white adipocyte genes but no difference in Pgc1a and Ucp1 expression, and higher fatty acid uptake but not mitochondrial biogenesis. triphenyl phosphate 95-114 peroxisome proliferator activated receptor gamma Mus musculus 50-59 34323617-11 2021 3T3-L1 cells treated with two known environmental PPARgamma ligands, tetrabromobisphenol A and triphenyl phosphate, which sorted distinctly from therapeutic ligands, had higher expression of white adipocyte genes but no difference in Pgc1a and Ucp1 expression, and higher fatty acid uptake but not mitochondrial biogenesis. triphenyl phosphate 95-114 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 234-239 34323617-11 2021 3T3-L1 cells treated with two known environmental PPARgamma ligands, tetrabromobisphenol A and triphenyl phosphate, which sorted distinctly from therapeutic ligands, had higher expression of white adipocyte genes but no difference in Pgc1a and Ucp1 expression, and higher fatty acid uptake but not mitochondrial biogenesis. triphenyl phosphate 95-114 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 244-248 35192884-0 2022 Prenatal exposure to triphenyl phosphate activated PPARgamma in placental trophoblasts and impaired pregnancy outcomes. triphenyl phosphate 21-40 peroxisome proliferator activated receptor gamma Mus musculus 51-60 35192884-2 2022 Using placental trophoblast cell line JEG-3, we demonstrated that TPhP could induce endoplasmic reticulum stress (ERS) and cell apoptosis through PPARgamma-mediated lipid metabolism. triphenyl phosphate 66-70 peroxisome proliferator activated receptor gamma Mus musculus 146-155 35192884-9 2022 Different with the effect on hormone level or angiogenesis, TPhP significantly increased PPARgamma and its regulated lipid transport proteins FABP, FATP, and CD36, and induced lipid accumulation in placental trophoblasts of both low- and high-exposure group. triphenyl phosphate 60-64 peroxisome proliferator activated receptor gamma Mus musculus 89-98 35192884-13 2022 The results showed that GW9662 could ameliorate the effect of TPhP on placental lipid accumulation, ERS and cell apoptosis, suggesting that PPARgamma mediated the placental toxicity of TPhP. triphenyl phosphate 62-66 peroxisome proliferator activated receptor gamma Mus musculus 140-149 35192884-13 2022 The results showed that GW9662 could ameliorate the effect of TPhP on placental lipid accumulation, ERS and cell apoptosis, suggesting that PPARgamma mediated the placental toxicity of TPhP. triphenyl phosphate 185-189 peroxisome proliferator activated receptor gamma Mus musculus 140-149 35192884-14 2022 Overall, our results indicated that prenatal TPhP exposure impaired pregnancy outcomes, at least partly through PPARgamma regulated function of trophoblast. triphenyl phosphate 45-49 peroxisome proliferator activated receptor gamma Mus musculus 112-121 32763690-6 2021 However, at the molecular level, the expression of ZHE1 and mmp9 was affected by the presence of the chorion in zebrafish embryos exposed to tributyl phosphate and triphenyl phosphate (TPHP), respectively. triphenyl phosphate 164-183 matrix metallopeptidase 9 Danio rerio 60-64 33189059-7 2021 Immunoblot and immunofluorescence analysis showed that exposure to TPHP reduced the protein levels of TUBB3 and SYP in the synapses of hippocampal neurons. triphenyl phosphate 67-71 tubulin, beta 3 class III Mus musculus 102-107 33189059-7 2021 Immunoblot and immunofluorescence analysis showed that exposure to TPHP reduced the protein levels of TUBB3 and SYP in the synapses of hippocampal neurons. triphenyl phosphate 67-71 synaptophysin Mus musculus 112-115 33189059-8 2021 TPHP exposure also downregulated the gene expression of neurotransmitter receptors including Grins, Htr1alpha, and Adra1alpha in a dose-dependent fashion. triphenyl phosphate 0-4 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 100-109 33189059-8 2021 TPHP exposure also downregulated the gene expression of neurotransmitter receptors including Grins, Htr1alpha, and Adra1alpha in a dose-dependent fashion. triphenyl phosphate 0-4 adrenergic receptor, alpha 1a Mus musculus 115-125 33189059-9 2021 Moreover, the calcium-dependent synaptic exocytosis governed by synaptic vesicle proteins STX1A and SYT1 was inhibited in the TPHP-treated hippocampus. triphenyl phosphate 126-130 syntaxin 1A (brain) Mus musculus 90-95 33189059-9 2021 Moreover, the calcium-dependent synaptic exocytosis governed by synaptic vesicle proteins STX1A and SYT1 was inhibited in the TPHP-treated hippocampus. triphenyl phosphate 126-130 synaptotagmin I Mus musculus 100-104 35007573-9 2022 Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. triphenyl phosphate 95-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 33662732-3 2021 TPP can disturb placental hormone secretion through the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. triphenyl phosphate 0-3 peroxisome proliferator activated receptor gamma Homo sapiens 56-104 33662732-3 2021 TPP can disturb placental hormone secretion through the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. triphenyl phosphate 0-3 peroxisome proliferator activated receptor gamma Homo sapiens 106-115 33662732-5 2021 In this study, we used JEG-3 cells to investigate the role of PPARgamma-regulated lipid metabolism in TPP-mediated placental toxicity. triphenyl phosphate 102-105 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 33662732-8 2021 Although PPARgamma and its target CCAAT/enhancer binding proteins (C/EBPalpha) was decreased, the TG content and gene expression of SREBP1, ACC, and CD36 decreased when TPP was co-exposed to the PPARgamma antagonist GW9662. triphenyl phosphate 169-172 peroxisome proliferator activated receptor gamma Homo sapiens 9-18 33662732-8 2021 Although PPARgamma and its target CCAAT/enhancer binding proteins (C/EBPalpha) was decreased, the TG content and gene expression of SREBP1, ACC, and CD36 decreased when TPP was co-exposed to the PPARgamma antagonist GW9662. triphenyl phosphate 169-172 peroxisome proliferator activated receptor gamma Homo sapiens 195-204 33662732-11 2021 Together, these results show that TPP can disturb lipid metabolism and cause lipid accumulation through PPARgamma, induce ERS, and cell apoptosis. triphenyl phosphate 34-37 peroxisome proliferator activated receptor gamma Homo sapiens 104-113 34023725-4 2021 In this work, an approach integrated in silico and in vitro was used to investigate the underlying toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway induced by triphenyl phosphate (TPP). triphenyl phosphate 206-225 poly(ADP-ribose) polymerase 1 Homo sapiens 160-165 34023725-4 2021 In this work, an approach integrated in silico and in vitro was used to investigate the underlying toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway induced by triphenyl phosphate (TPP). triphenyl phosphate 227-230 poly(ADP-ribose) polymerase 1 Homo sapiens 160-165 34023725-5 2021 Docking view showed that TPP could interact with helix alphaJ to affect the activation of PARP1 as a molecular initial event. triphenyl phosphate 25-28 poly(ADP-ribose) polymerase 1 Homo sapiens 90-95 33454525-8 2021 In addition, molecular docking revealed that TPHP, TCP, CDP and CPF bound to AChE with glide scores of - 7.8, - 8.3, - 8.1 and - 7.3, respectively. triphenyl phosphate 45-49 acetylcholinesterase Danio rerio 77-81 32763690-6 2021 However, at the molecular level, the expression of ZHE1 and mmp9 was affected by the presence of the chorion in zebrafish embryos exposed to tributyl phosphate and triphenyl phosphate (TPHP), respectively. triphenyl phosphate 185-189 matrix metallopeptidase 9 Danio rerio 60-64 32763690-7 2021 Furthermore, in zebrafish embryos exposed to TPHP, the increased expression of miR-137 and miR-141 was abolished by the presence of the chorion. triphenyl phosphate 45-49 microRNA 137-1 Danio rerio 79-86 32763690-7 2021 Furthermore, in zebrafish embryos exposed to TPHP, the increased expression of miR-137 and miR-141 was abolished by the presence of the chorion. triphenyl phosphate 45-49 microRNA 141 Danio rerio 91-98 32683515-0 2020 Triphenyl phosphate is a selective PPARgamma modulator that does not induce brite adipogenesis in vitro and in vivo. triphenyl phosphate 0-19 peroxisome proliferator activated receptor gamma Mus musculus 35-44 32683515-1 2020 Triphenyl phosphate (TPhP) is an environmental PPARgamma ligand, and growing evidence suggests that it is a metabolic disruptor. triphenyl phosphate 0-19 peroxisome proliferator activated receptor gamma Mus musculus 47-56 32683515-1 2020 Triphenyl phosphate (TPhP) is an environmental PPARgamma ligand, and growing evidence suggests that it is a metabolic disruptor. triphenyl phosphate 21-25 peroxisome proliferator activated receptor gamma Mus musculus 47-56 32683515-3 2020 Here, using in vivo and in vitro models, we tested the hypothesis that TPhP is a selective PPARgamma ligand, which fails to induce brite adipogenesis. triphenyl phosphate 71-75 peroxisome proliferator activated receptor gamma Mus musculus 91-100 32683515-13 2020 We conclude that TPhP is a selective PPARgamma modulator that fails to protect PPARgamma from phosphorylation at ser273. triphenyl phosphate 17-21 peroxisome proliferator activated receptor gamma Mus musculus 37-46 32216303-8 2020 Two examples are chosen to demonstrate the synergy advantage in elucidation of metabolic mechanism of triphenyl phosphate and atrazine catalyzed by CYP, respectively, which shows the interplay between experiments and computations allows gaining greater insight than the isolated methods. triphenyl phosphate 102-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-151 32259740-3 2020 The expression of the gene encoding lysophosphatidylcholine acyltransferase 3 (Lpcat3) was significantly downregulated by 0.76 +- 0.03 and 0.70 +- 0.08-fold in 10 and 20 muM TPHP exposure groups, relative to the control group. triphenyl phosphate 174-178 lysophosphatidylcholine acyltransferase 3 Mus musculus 36-77 32259740-3 2020 The expression of the gene encoding lysophosphatidylcholine acyltransferase 3 (Lpcat3) was significantly downregulated by 0.76 +- 0.03 and 0.70 +- 0.08-fold in 10 and 20 muM TPHP exposure groups, relative to the control group. triphenyl phosphate 174-178 lysophosphatidylcholine acyltransferase 3 Mus musculus 79-85 33618456-7 2020 GO and TPhP coexposure activated the mTOR signaling pathway and subsequently promoted apoptosis in zebrafish by potentiating the oxidative stress induced by TPhP, presenting synergistic toxicity. triphenyl phosphate 7-11 mechanistic target of rapamycin kinase Danio rerio 37-41 32379252-7 2020 Fe3O4@SiO2@TpPa-Ti4+ nanoparticles also demonstrate high sensitivity (above 0.2 fmol muL-1) and selectivity (alpha-casein : BSA = 1 : 5000). triphenyl phosphate 11-15 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 85-90 32443217-0 2020 miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP). triphenyl phosphate 73-92 microRNA 137-1 Danio rerio 0-7 32443217-0 2020 miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP). triphenyl phosphate 73-92 microRNA 141 Danio rerio 12-19 32443217-0 2020 miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP). triphenyl phosphate 94-98 microRNA 137-1 Danio rerio 0-7 32443217-0 2020 miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP). triphenyl phosphate 94-98 microRNA 141 Danio rerio 12-19 32443217-6 2020 Also, we identified two microRNAs (i.e., miR-137 and miR-141) and observed their differential over-expression in TPHP-exposed zebrafish embryos. triphenyl phosphate 113-117 microRNA 137-1 Danio rerio 41-48 32443217-6 2020 Also, we identified two microRNAs (i.e., miR-137 and miR-141) and observed their differential over-expression in TPHP-exposed zebrafish embryos. triphenyl phosphate 113-117 microRNA 141 Danio rerio 53-60 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 103-107 microRNA 137-1 Danio rerio 25-32 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 103-107 microRNA 141 Danio rerio 37-44 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 103-107 matrix metallopeptidase 9 Danio rerio 83-87 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 103-107 SRY-box transcription factor 9b Danio rerio 92-97 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 258-262 microRNA 137-1 Danio rerio 25-32 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 258-262 microRNA 141 Danio rerio 37-44 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 258-262 matrix metallopeptidase 9 Danio rerio 83-87 32443217-7 2020 In the microinjection of miR-137 and miR-141 inhibitors, the reduced expression of mmp9 and sox9b upon TPHP exposure was compensated, indicating that epigenetic deregulation of miRNAs modulated putative genes involved in phenotypic tail defects triggered by TPHP in developing zebrafish embryos. triphenyl phosphate 258-262 SRY-box transcription factor 9b Danio rerio 92-97 31940434-4 2020 Reaction with N-bromosuccinimide (NBS)/triphenyl phosphine (PPh3) regioselectively brominates the sole primary alcohol of linear, unbranched dextran (which is an -1-6 linked homopolymer of glucose) at C-6 of the non-reducing end monosaccharide. triphenyl phosphate 39-58 caveolin 1 Homo sapiens 60-64 31796355-0 2020 Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice. triphenyl phosphate 0-19 adiponectin, C1Q and collagen domain containing Mus musculus 98-109 31796355-3 2020 Herein, we observed the insulin-sensitizing hormone (adiponectin) was inhibited in female serum while stimulated in males after oral administration of TPhP. triphenyl phosphate 151-155 adiponectin, C1Q and collagen domain containing Mus musculus 53-64 31796355-8 2020 Comparably, TPhP upregulated the AdipoR 1/2 and induced the downstream (pAMPK and PPAR signaling) in males. triphenyl phosphate 12-16 adiponectin receptor 1 Mus musculus 33-43 31796355-8 2020 Comparably, TPhP upregulated the AdipoR 1/2 and induced the downstream (pAMPK and PPAR signaling) in males. triphenyl phosphate 12-16 peroxisome proliferator activated receptor alpha Mus musculus 82-86 31796355-11 2020 Our research firstly revealed TPhP-induced hepatic nutrient metabolism was partially mediated by the adiponectin/AdipoR pathway in sexual-dependent manner during pubertal. triphenyl phosphate 30-34 adiponectin, C1Q and collagen domain containing Mus musculus 101-112