PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30988014-4 2019 Here, we demonstrate that pharmacological inhibition of Forkhead box subclass O (FoxO) transcription factors using the small-molecule inhibitor AS1842856 significantly blunts sGC alpha and beta mRNA expression by more than 90%. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 144-153 sarcoglycan alpha Homo sapiens 175-184 30805760-2 2019 Resveratrol (RSV) has been regarded as potent SIRT1 activator in the treatment of atherosclerosis and cardiovascular diseases. Resveratrol 13-16 sirtuin 1 Homo sapiens 46-51 21221775-3 2011 The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF) in the hippocampus of rat brain. Resveratrol 64-75 brain-derived neurotrophic factor Rattus norvegicus 110-143 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 63-66 sirtuin 1 Homo sapiens 44-49 21221775-3 2011 The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF) in the hippocampus of rat brain. Resveratrol 64-75 brain-derived neurotrophic factor Rattus norvegicus 145-149 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 63-66 sirtuin 1 Homo sapiens 112-117 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 63-66 sirtuin 1 Homo sapiens 112-117 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 63-66 sirtuin 1 Homo sapiens 112-117 21221775-7 2011 The findings suggest that the neuroprotective effects of resveratrol may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA. Resveratrol 57-68 brain-derived neurotrophic factor Rattus norvegicus 152-156 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 88-91 sirtuin 1 Homo sapiens 44-49 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 88-91 sirtuin 1 Homo sapiens 112-117 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 88-91 sirtuin 1 Homo sapiens 112-117 30805760-3 2019 Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function. Resveratrol 88-91 sirtuin 1 Homo sapiens 112-117 21239502-0 2011 Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Resveratrol 0-11 sirtuin 1 Homo sapiens 21-27 30805760-5 2019 Moreover, the dynamics properties of three RSV in the binding site of SIRT1 are still unknown. Resveratrol 43-46 sirtuin 1 Homo sapiens 70-75 30805760-14 2019 Our work elucidated the inequable contributions of three RSV on their binding interaction with SIRT1 and indicated that the binding sites of RSV1 and RSV2 should be enough to design more potent SIRT1 activator. Resveratrol 57-60 sirtuin 1 Homo sapiens 95-100 21239502-0 2011 Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Resveratrol 0-11 TNF superfamily member 11 Homo sapiens 60-98 30805760-14 2019 Our work elucidated the inequable contributions of three RSV on their binding interaction with SIRT1 and indicated that the binding sites of RSV1 and RSV2 should be enough to design more potent SIRT1 activator. Resveratrol 57-60 sirtuin 1 Homo sapiens 194-199 21239502-0 2011 Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Resveratrol 0-11 TNF superfamily member 11 Homo sapiens 100-105 30917543-4 2019 We found that resveratrol exhibits a more potent inhibitory capacity towards alpha-glucosidase than pancreatic lipase activity. Resveratrol 14-25 pancreatic lipase Homo sapiens 100-117 21239502-5 2011 In this study, we investigated the effects of resveratrol on RANKL during bone morphogenesis in high density bone cultures in vitro. Resveratrol 46-57 TNF superfamily member 11 Homo sapiens 61-66 30917533-5 2019 METHODS: We investigated the underlying molecular mechanisms of resveratrol on TNF-beta/TNF-betaR-induced EMT and migration of CRC cells (HCT116, RKO, SW480) in monolayer or 3D alginate cultures. Resveratrol 64-75 lymphotoxin alpha Homo sapiens 79-87 30917533-9 2019 Furthermore, we found that resveratrol suppressed TNF-beta-induced NF-kappaB and NF-kappaB-regulated gene biomarkers associated with growth, proliferation, and invasion. Resveratrol 27-38 lymphotoxin alpha Homo sapiens 50-58 30917533-11 2019 CONCLUSION: These results suggest that resveratrol down-regulates TNF-beta/TNF-betaR-induced EMT, at least in part via specific suppression of NF-kappaBeta and FAK in CRC cells. Resveratrol 39-50 lymphotoxin alpha Homo sapiens 66-74 21239502-10 2011 Resveratrol inhibited RANKL-induced acetylation and nuclear translocation of NF-kappaB in a time- and concentration-dependent manner. Resveratrol 0-11 TNF superfamily member 11 Homo sapiens 22-27 30697969-0 2019 Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/beta-catenin signaling pathway in breast cancer. Resveratrol 0-11 sirtuin 1 Homo sapiens 113-118 21239502-11 2011 In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and preosteoblastic cells, leading to deacetylation of RANKL-induced NF-kappaB, inhibition of NF-kappaB transcriptional activation, and osteoclastogenesis. Resveratrol 61-72 sirtuin 1 Homo sapiens 27-33 21239502-11 2011 In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and preosteoblastic cells, leading to deacetylation of RANKL-induced NF-kappaB, inhibition of NF-kappaB transcriptional activation, and osteoclastogenesis. Resveratrol 61-72 sirtuin 1 Homo sapiens 81-87 21239502-11 2011 In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and preosteoblastic cells, leading to deacetylation of RANKL-induced NF-kappaB, inhibition of NF-kappaB transcriptional activation, and osteoclastogenesis. Resveratrol 61-72 TNF superfamily member 11 Homo sapiens 176-181 21239502-12 2011 Co-treatment with resveratrol activated the bone transcription factors Cbfa-1 and Sirt-1 and induced the formation of Sirt-1-Cbfa-1 complexes. Resveratrol 18-29 sirtuin 1 Homo sapiens 82-88 21239502-12 2011 Co-treatment with resveratrol activated the bone transcription factors Cbfa-1 and Sirt-1 and induced the formation of Sirt-1-Cbfa-1 complexes. Resveratrol 18-29 sirtuin 1 Homo sapiens 118-124 30207743-3 2019 At present, polypeptides targeting G3BP1 have shown anti-tumour activity and G3BP1 also involved in anti-cancer effects of some polyphenolic compounds (resveratrol and EGCG). Resveratrol 152-163 G3BP stress granule assembly factor 1 Homo sapiens 35-40 21239502-13 2011 Overall, these results demonstrate that resveratrol-activated Sirt-1 plays pivotal roles in regulating the balance between the osteoclastic versus osteoblastic activity result in bone formation in vitro thereby highlighting its therapeutic potential for treating osteoporosis and rheumatoid arthritis-related bone loss. Resveratrol 40-51 sirtuin 1 Homo sapiens 62-68 30207743-3 2019 At present, polypeptides targeting G3BP1 have shown anti-tumour activity and G3BP1 also involved in anti-cancer effects of some polyphenolic compounds (resveratrol and EGCG). Resveratrol 152-163 G3BP stress granule assembly factor 1 Homo sapiens 77-82 21048045-4 2011 These effects were abolished by actinomycin D or cycloheximide or by the AhR antagonists resveratrol and alpha-naphthoflavone. Resveratrol 89-100 aryl hydrocarbon receptor Rattus norvegicus 73-76 30637441-6 2019 Metabolic labeling and pull-down assays to investigate de novo protein synthesis clearly demonstrated that intracellular pro-IL-1beta synthesis is rapidly repressed in monocytes after resveratrol treatment due to decreased phosphorylation of Syk and p38. Resveratrol 184-195 spleen associated tyrosine kinase Homo sapiens 242-245 30637441-10 2019 KEY MESSAGE: Resveratrol has negative effects on pro-IL-1beta synthesis through Syk and p38. Resveratrol 13-24 spleen tyrosine kinase Mus musculus 80-83 30840305-0 2019 Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway. Resveratrol 0-11 nitric oxide synthase 3 Rattus norvegicus 137-142 30840305-17 2019 CONCLUSIONS: RSV protects cardiomyocyte apoptosis from ischemia-reperfusion injury through regulating phosphorylation levels of proteins relative to PI3K/Akt/e-NOS pathway. Resveratrol 13-16 nitric oxide synthase 3 Rattus norvegicus 158-163 30600470-8 2019 In the in vitro experiment, the protein levels of SIRT1 were downregulated in PBMCs from IG patients exposed to MSU crystals and were restored by resveratrol in a dose-dependent manner. Resveratrol 146-157 sirtuin 1 Homo sapiens 50-55 30600470-12 2019 CONCLUSION: These findings suggest that resveratrol ameliorates gouty inflammation via upregulation of SIRT1 to promote autophagy in patients with gout. Resveratrol 40-51 sirtuin 1 Homo sapiens 103-108 30225723-0 2019 Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats. Resveratrol 11-22 uncoupling protein 2 Rattus norvegicus 40-44 30225723-13 2019 UCP2 mediated the protective effects of RES on diabetic hearts. Resveratrol 40-43 uncoupling protein 2 Rattus norvegicus 0-4 30535465-5 2019 Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the beta2-adrenergic receptor (ADRB-2); in addition, the protein expression of hypoxia-inducible factor (HIF)-1alpha was suppressed by resveratrol in a dose-dependent manner. Resveratrol 10-21 adrenoceptor beta 2 Homo sapiens 112-137 30535465-5 2019 Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the beta2-adrenergic receptor (ADRB-2); in addition, the protein expression of hypoxia-inducible factor (HIF)-1alpha was suppressed by resveratrol in a dose-dependent manner. Resveratrol 10-21 adrenoceptor beta 2 Homo sapiens 139-145 30787995-6 2019 In addition, Rev upregulated the expression of MMP9, VEGF, and Cadherin5, indicating that Rev promotes angiogenesis in ischemic flaps. Resveratrol 13-16 matrix metallopeptidase 9 Rattus norvegicus 47-51 30257140-4 2019 Hypothetically, the resveratrol-induced upregulation of gap junctions may improve the bystander effect that HSV-TK/GCV has on hepatoma cells. Resveratrol 20-31 transketolase Rattus norvegicus 112-114 30257140-8 2019 The present results demonstrate that resveratrol can enhance the bystander effect exerted by the HSV-TK/GCV system by enhancing connexin-mediated gap junctional communication. Resveratrol 37-48 transketolase Rattus norvegicus 101-103 30526144-0 2019 Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signalling pathway. Resveratrol 0-11 vascular endothelial growth factor B Rattus norvegicus 89-95 30526144-0 2019 Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signalling pathway. Resveratrol 0-11 nitric oxide synthase 3 Rattus norvegicus 101-105 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 35-46 vascular endothelial growth factor B Rattus norvegicus 200-236 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 35-46 vascular endothelial growth factor B Rattus norvegicus 238-244 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 48-51 vascular endothelial growth factor B Rattus norvegicus 200-236 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 48-51 vascular endothelial growth factor B Rattus norvegicus 238-244 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 53-79 vascular endothelial growth factor B Rattus norvegicus 200-236 30526144-1 2019 According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. Resveratrol 53-79 vascular endothelial growth factor B Rattus norvegicus 238-244 30526144-7 2019 Furthermore, it showed that RSV pretreatment increased VEGF-B, p-eNOS and p-AMPK expression, and NO production in ISO-treated rats. Resveratrol 28-31 vascular endothelial growth factor B Rattus norvegicus 55-61 30526144-7 2019 Furthermore, it showed that RSV pretreatment increased VEGF-B, p-eNOS and p-AMPK expression, and NO production in ISO-treated rats. Resveratrol 28-31 nitric oxide synthase 3 Rattus norvegicus 65-69 30526144-8 2019 Using Neonatal Rat Ventricular Myocytes (NRVM), we found that VEGF-B siRNA could abolish the cardio-protective effect of RSV. Resveratrol 121-124 vascular endothelial growth factor B Rattus norvegicus 62-68 30526144-9 2019 The enhanced ratios of eNOS phosphorylation to eNOS expression induced by RSV were markedly reversed by VEGF-B siRNA in NRVM also. Resveratrol 74-77 nitric oxide synthase 3 Rattus norvegicus 23-27 30526144-9 2019 The enhanced ratios of eNOS phosphorylation to eNOS expression induced by RSV were markedly reversed by VEGF-B siRNA in NRVM also. Resveratrol 74-77 nitric oxide synthase 3 Rattus norvegicus 47-51 30526144-9 2019 The enhanced ratios of eNOS phosphorylation to eNOS expression induced by RSV were markedly reversed by VEGF-B siRNA in NRVM also. Resveratrol 74-77 vascular endothelial growth factor B Rattus norvegicus 104-110 30526144-11 2019 L-NAME, a NOS inhibitor, could inhibit RSV enhanced eNOS phosphorylation but had no effect on VEGF-B expression in NRVM or in rats. Resveratrol 39-42 nitric oxide synthase 3 Rattus norvegicus 52-56 30526144-12 2019 Collectively, our results indicate that RSV exerts cardio-protection from ISO-induced myocardial infarction through VEGF-B/AMPK/eNOS/NO signalling pathway. Resveratrol 40-43 vascular endothelial growth factor B Rattus norvegicus 116-122 30526144-12 2019 Collectively, our results indicate that RSV exerts cardio-protection from ISO-induced myocardial infarction through VEGF-B/AMPK/eNOS/NO signalling pathway. Resveratrol 40-43 nitric oxide synthase 3 Rattus norvegicus 128-132 30244113-13 2018 In conclusion, our study revealed that resveratrol and DMF exerted promising antidepressant-like effects in CUMS rats that are mediated in part by suppressing the neuroinflammation, oxidative stress, apoptosis and up-regulating hippocampal BDNF and beta-catenin levels. Resveratrol 39-50 brain-derived neurotrophic factor Rattus norvegicus 240-244 30342188-0 2018 Resveratrol protects photoreceptors by blocking caspase- and PARP-dependent cell death pathways. Resveratrol 0-11 poly (ADP-ribose) polymerase family, member 1 Mus musculus 61-65 30342188-8 2018 The level of caspase-9 and caspase-3, upregulated following GD, were reduced by treatment with RSV. Resveratrol 95-98 caspase 3 Mus musculus 27-36 30342188-9 2018 Similarly, the level of PARP-1 and AIF, upregulated following light exposure, were decreased by treatment with RSV. Resveratrol 111-114 poly (ADP-ribose) polymerase family, member 1 Mus musculus 24-30 30464073-3 2018 Effect of resveratrol on IL-1beta-induced secretion of MMP-3 was investigated in rabbit articular chondrocytes using western blot analysis. Resveratrol 10-21 stromelysin-1 Oryctolagus cuniculus 55-60 30343279-3 2018 Our study aimed to examine the combined anticancer effects of As2O3 and resveratrol against human neuroblastoma SK-N-SH cells, and elucidate the underlying intracellular signaling. Resveratrol 72-83 hedgehog acyltransferase Homo sapiens 112-116 30399060-12 2018 Moreover, RSV-enhanced human umbilical vein endothelial cells healing through Sirt1/ER pathway may be involved in the prevention of leukocyte extravasation. Resveratrol 10-13 sirtuin 1 Homo sapiens 78-83 30184338-2 2018 In this study, two food factors, resveratrol (RSV) and genistein (GEN), that are able to regulate beta2 -AR promoter activity and may improve skeletal muscle function are identified. Resveratrol 33-44 hemoglobin, beta adult minor chain Mus musculus 98-103 30184338-2 2018 In this study, two food factors, resveratrol (RSV) and genistein (GEN), that are able to regulate beta2 -AR promoter activity and may improve skeletal muscle function are identified. Resveratrol 46-49 hemoglobin, beta adult minor chain Mus musculus 98-103 30184338-3 2018 METHODS AND RESULTS: Using luciferase reporter assay, 357 functional food factors as candidates for beta2 -AR promoter activity have been screened and subsequently RSV and GEN increase beta2 -AR promoter activity and beta2 -AR mRNA expression. Resveratrol 164-167 hemoglobin, beta adult minor chain Mus musculus 100-105 30132535-4 2018 Furthermore, relative expression of autophagy-related proteins Beclin1 and LC3 II/I ratio was increased while p62 expression was decreased by resveratrol treatment dose-dependently. Resveratrol 142-153 beclin 1 Homo sapiens 63-70 30132535-4 2018 Furthermore, relative expression of autophagy-related proteins Beclin1 and LC3 II/I ratio was increased while p62 expression was decreased by resveratrol treatment dose-dependently. Resveratrol 142-153 nucleoporin 62 Homo sapiens 110-113 30348945-7 2018 Resveratrol induced nuclear FoxO3a accumulation and the expression of autophagy-related genes, which are targets of FoxOs. Resveratrol 0-11 forkhead box O3 Mus musculus 28-34 30055241-5 2018 Furthermore, the expression of SIRT1 was markedly downregulated by Sb treatment, while overexpression of SIRT1 through resveratrol treatment or transfection with SIRT1-Flag plasmid attenuated the Sb-induced apoptosis. Resveratrol 119-130 sirtuin 1 Homo sapiens 105-110 30055241-5 2018 Furthermore, the expression of SIRT1 was markedly downregulated by Sb treatment, while overexpression of SIRT1 through resveratrol treatment or transfection with SIRT1-Flag plasmid attenuated the Sb-induced apoptosis. Resveratrol 119-130 sirtuin 1 Homo sapiens 105-110 30304866-9 2018 The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism. Resveratrol 162-173 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 233-237 30301188-8 2018 Both losartan and resveratrol restored hippocampal-dependent contextual memory by NADPH oxidase 2 (NOX2) deletion and superoxide dismutase 2 (SOD2) elevation. Resveratrol 18-29 cytochrome b-245 beta chain Rattus norvegicus 82-97 30301188-8 2018 Both losartan and resveratrol restored hippocampal-dependent contextual memory by NADPH oxidase 2 (NOX2) deletion and superoxide dismutase 2 (SOD2) elevation. Resveratrol 18-29 cytochrome b-245 beta chain Rattus norvegicus 99-103 30301188-8 2018 Both losartan and resveratrol restored hippocampal-dependent contextual memory by NADPH oxidase 2 (NOX2) deletion and superoxide dismutase 2 (SOD2) elevation. Resveratrol 18-29 superoxide dismutase 2 Rattus norvegicus 118-140 30301188-8 2018 Both losartan and resveratrol restored hippocampal-dependent contextual memory by NADPH oxidase 2 (NOX2) deletion and superoxide dismutase 2 (SOD2) elevation. Resveratrol 18-29 superoxide dismutase 2 Rattus norvegicus 142-146 30026090-0 2018 Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin alphavbeta3 and IGF-1R. Resveratrol 0-11 integrin subunit alpha V Homo sapiens 78-98 30026090-0 2018 Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin alphavbeta3 and IGF-1R. Resveratrol 0-11 insulin like growth factor 1 receptor Homo sapiens 103-109 30026090-4 2018 Resveratrol arrested cell proliferation via integrin alphavbeta3. Resveratrol 0-11 integrin subunit alpha V Homo sapiens 44-64 30026090-9 2018 The accumulation of insulin-like growth factor (IGF)-1 receptor (IGF-1R) was inhibited by resveratrol in primary myoma cells. Resveratrol 90-101 insulin like growth factor 1 receptor Homo sapiens 20-63 30026090-9 2018 The accumulation of insulin-like growth factor (IGF)-1 receptor (IGF-1R) was inhibited by resveratrol in primary myoma cells. Resveratrol 90-101 insulin like growth factor 1 receptor Homo sapiens 65-71 30027502-4 2018 Resveratrol is a stilbenoid phytoalexin which binds to a specific site on the cell surface integrin alphavbeta3 to trigger cancer cell death via nuclear translocation of COX-2. Resveratrol 0-11 integrin subunit alpha V Homo sapiens 91-111 20972827-0 2011 Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1. Resveratrol 0-11 sirtuin 1 Homo sapiens 90-99 30027502-7 2018 RRM2 downregulation, whether achieved by RNA interference or treatment with NDAT, enhanced resveratrol-induced COX-2 gene expression and nuclear uptake which is essential to integrin alphavbeta3-mediated-resveratrol-induced antiproliferation in cancer cells. Resveratrol 91-102 integrin subunit alpha V Homo sapiens 174-194 30027502-7 2018 RRM2 downregulation, whether achieved by RNA interference or treatment with NDAT, enhanced resveratrol-induced COX-2 gene expression and nuclear uptake which is essential to integrin alphavbeta3-mediated-resveratrol-induced antiproliferation in cancer cells. Resveratrol 204-215 integrin subunit alpha V Homo sapiens 174-194 20972827-5 2011 The role of SIRT1 in cell-cycle effects mediated by resveratrol was studied through changes in the expression of SIRT1 using western blot. Resveratrol 52-63 sirtuin 1 Homo sapiens 12-17 20972827-5 2011 The role of SIRT1 in cell-cycle effects mediated by resveratrol was studied through changes in the expression of SIRT1 using western blot. Resveratrol 52-63 sirtuin 1 Homo sapiens 113-118 30179628-0 2018 Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-kappaB activation. Resveratrol 0-11 sphingosine kinase 1 Rattus norvegicus 91-96 20972827-6 2011 Exposure to resveratrol decreased SIRT1 content, concomitant with an increase in the acetylated form of sirtuin substrates p53 and NFkappa-beta. Resveratrol 12-23 sirtuin 1 Homo sapiens 34-39 30179628-1 2018 AIMS: This study aims to explore the molecular mechanisms underlying sphingosine kinase 1 (SphK1) inducing pulmonary vascular remodeling and resveratrol suppressing pulmonary arterial hypertension (PAH). Resveratrol 141-152 sphingosine kinase 1 Rattus norvegicus 69-89 20972827-10 2011 Our results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis. Resveratrol 73-84 sirtuin 1 Homo sapiens 36-41 30179628-1 2018 AIMS: This study aims to explore the molecular mechanisms underlying sphingosine kinase 1 (SphK1) inducing pulmonary vascular remodeling and resveratrol suppressing pulmonary arterial hypertension (PAH). Resveratrol 141-152 sphingosine kinase 1 Rattus norvegicus 91-96 30179628-10 2018 In addition, resveratrol effectively inhibited the development of PAH by suppression of SphK1/S1P-mediated NF-kappaB activation and subsequent cyclin D1 expression. Resveratrol 13-24 sphingosine kinase 1 Rattus norvegicus 88-93 21304978-3 2011 The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice. Resveratrol 79-90 KRAS proto-oncogene, GTPase Homo sapiens 183-187 30179628-12 2018 Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. Resveratrol 0-11 sphingosine kinase 1 Rattus norvegicus 57-62 30179628-12 2018 Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. Resveratrol 0-11 sphingosine kinase 1 Rattus norvegicus 102-107 21304978-8 2011 Resveratrol inhibits the self-renewal capacity of pancreatic CSCs derived from human primary tumors and Kras(G12D) mice. Resveratrol 0-11 KRAS proto-oncogene, GTPase Homo sapiens 104-108 30179628-12 2018 Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. Resveratrol 125-136 sphingosine kinase 1 Rattus norvegicus 57-62 30179628-12 2018 Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. Resveratrol 125-136 sphingosine kinase 1 Rattus norvegicus 102-107 21304978-9 2011 Resveratrol induces apoptosis by activating capase-3/7 and inhibiting the expression of Bcl-2 and XIAP in human CSCs. Resveratrol 0-11 X-linked inhibitor of apoptosis Homo sapiens 98-102 21304978-10 2011 Resveratrol inhibits pluripotency maintaining factors (Nanog, Sox-2, c-Myc and Oct-4) and drug resistance gene ABCG2 in CSCs. Resveratrol 0-11 SRY (sex determining region Y)-box 2 Mus musculus 62-67 21304978-12 2011 Finally, resveratrol inhibits CSC"s migration and invasion and markers of epithelial-mesenchymal transition (Zeb-1, Slug and Snail). Resveratrol 9-20 snail family zinc finger 1 Mus musculus 125-130 21304978-13 2011 CONCLUSIONS/SIGNIFICANCE: These data suggest that resveratrol inhibits pancreatic cancer stem cell characteristics in human and Kras(G12D) transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. Resveratrol 50-61 KRAS proto-oncogene, GTPase Homo sapiens 128-132 30243024-7 2018 We found that activation of Sirt1 by resveratrol enhanced tau exon 10 inclusion, leading to 4R-tau expression. Resveratrol 37-48 sirtuin 1 Homo sapiens 28-33 21144831-7 2011 Moreover, we also examined the transcript levels of Mash1, Ngn2, and HB9 mRNA in the differentiated NPCs treated with the Sirt1 activator resveratrol (50 muM) or inhibitor nicotinamide (100 muM). Resveratrol 138-149 sirtuin 1 Homo sapiens 122-127 29964052-8 2018 With ROS elevation, resveratrol decreased DNMT1 and increased DLC1 expression significantly. Resveratrol 20-31 DNA methyltransferase 1 Homo sapiens 42-47 29964052-9 2018 However, after ROS scavenger NAC was added to the cancer cells treated by resveratrol, DNMT1, DLC1 and senescence-associated molecular markers were reversed. Resveratrol 74-85 DNA methyltransferase 1 Homo sapiens 87-92 29964052-12 2018 Moreover, DLC1 promoted senescence through FoxO3a/NF-kappaB signaling mediated by SIRT1 after resveratrol treatment. Resveratrol 94-105 sirtuin 1 Homo sapiens 82-87 20980258-3 2011 The stimulatory effect of RSV was not affected by knocking out Sirt1, but was diminished by suppressing the expression levels of DsbA-L, a recently identified adiponectin-interactive protein that promotes adiponectin multimerization. Resveratrol 26-29 sirtuin 1 Homo sapiens 63-68 20980258-7 2011 Taken together, our results demonstrate that RSV promotes adiponectin multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. Resveratrol 45-48 sirtuin 1 Homo sapiens 113-118 30213073-0 2018 Resveratrol Suppresses Matrix Metalloproteinase-2 Activation Induced by Lipopolysaccharide in Mouse Osteoblasts via Interactions with AMP-Activated Protein Kinase and Suppressor of Cytokine Signaling 1. Resveratrol 0-11 matrix metallopeptidase 2 Mus musculus 23-49 22112770-2 2011 To produce resveratrol in a food-grade yeast, the 4-coumarate:coenzyme A ligase gene (4CL1) from Arabidopsis thaliana and stilbene synthase gene (STS) from Arachis hypogaea were cloned and transformed into Saccharomyces cerevisiae W303-1A. Resveratrol 11-22 stachyose synthase Arabidopsis thaliana 122-144 30213073-0 2018 Resveratrol Suppresses Matrix Metalloproteinase-2 Activation Induced by Lipopolysaccharide in Mouse Osteoblasts via Interactions with AMP-Activated Protein Kinase and Suppressor of Cytokine Signaling 1. Resveratrol 0-11 suppressor of cytokine signaling 1 Mus musculus 167-201 30213073-10 2018 In addition, AMPK inhibition blocked the effects of resveratrol on MMP-2 expression and activity in LPS-induced MC3T3-E1 cells. Resveratrol 52-63 matrix metallopeptidase 2 Mus musculus 67-72 30213073-11 2018 Treatment with resveratrol also induced suppressor of cytokine signaling 1 (SOCS1) expression in MC3T3-E1 cells. Resveratrol 15-26 suppressor of cytokine signaling 1 Mus musculus 40-74 30213073-11 2018 Treatment with resveratrol also induced suppressor of cytokine signaling 1 (SOCS1) expression in MC3T3-E1 cells. Resveratrol 15-26 suppressor of cytokine signaling 1 Mus musculus 76-81 30213073-12 2018 SOCS1 siRNA negated the inhibitory effects of resveratrol on LPS-induced MMP-2 production. Resveratrol 46-57 suppressor of cytokine signaling 1 Mus musculus 0-5 30213073-12 2018 SOCS1 siRNA negated the inhibitory effects of resveratrol on LPS-induced MMP-2 production. Resveratrol 46-57 matrix metallopeptidase 2 Mus musculus 73-78 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 14-25 suppressor of cytokine signaling 1 Mus musculus 34-39 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 14-25 suppressor of cytokine signaling 1 Mus musculus 135-140 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 14-25 matrix metallopeptidase 2 Mus musculus 225-230 21130087-1 2011 One of the functions mediated by sirtuin 1 (SIRT1), the NAD(+)-dependent protein deacetylase, has been suggested to be neuroprotective since resveratrol, a SIRT1 activator, inhibits 1-methyl-4-phenylpyridinium ion (MPP(+))-induced cytotoxicity. Resveratrol 141-152 sirtuin 1 Homo sapiens 33-42 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 14-25 suppressor of cytokine signaling 1 Mus musculus 135-140 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 190-201 suppressor of cytokine signaling 1 Mus musculus 34-39 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 190-201 suppressor of cytokine signaling 1 Mus musculus 135-140 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 190-201 matrix metallopeptidase 2 Mus musculus 225-230 30213073-13 2018 Additionally, resveratrol-induced SOCS1 upregulation was reduced by treatment with compound C. These results demonstrate that AMPK and SOCS1 activation are important signaling events during resveratrol-mediated inhibition of MMP-2 production in response to LPS in MC3T3-E1 cells, and there is crosstalk between AMPK and SOCS1 signaling. Resveratrol 190-201 suppressor of cytokine signaling 1 Mus musculus 135-140 30030988-5 2018 Trans-resveratrol further downregulated the expression of these genes except Lpl, Rdh5, and Rdh12 but upregulated Cyp26b1. Resveratrol 0-17 retinol dehydrogenase 12 Rattus norvegicus 92-97 30030988-5 2018 Trans-resveratrol further downregulated the expression of these genes except Lpl, Rdh5, and Rdh12 but upregulated Cyp26b1. Resveratrol 0-17 cytochrome P450, family 26, subfamily b, polypeptide 1 Rattus norvegicus 114-121 21130087-1 2011 One of the functions mediated by sirtuin 1 (SIRT1), the NAD(+)-dependent protein deacetylase, has been suggested to be neuroprotective since resveratrol, a SIRT1 activator, inhibits 1-methyl-4-phenylpyridinium ion (MPP(+))-induced cytotoxicity. Resveratrol 141-152 sirtuin 1 Homo sapiens 44-49 30030988-7 2018 Trans-resveratrol normalized Rdh5 and increased Lrat and Rdh10 transcriptions compared to control and diabetic rats. Resveratrol 0-17 lecithin retinol acyltransferase Rattus norvegicus 48-52 21130087-1 2011 One of the functions mediated by sirtuin 1 (SIRT1), the NAD(+)-dependent protein deacetylase, has been suggested to be neuroprotective since resveratrol, a SIRT1 activator, inhibits 1-methyl-4-phenylpyridinium ion (MPP(+))-induced cytotoxicity. Resveratrol 141-152 sirtuin 1 Homo sapiens 156-161 30030988-8 2018 Trans-resveratrol amplified diabetes-induced inhibition of RPE65, but it inhibited the induced increase in Crabp1 transcription on 30d. Resveratrol 0-17 retinoid isomerohydrolase RPE65 Rattus norvegicus 59-64 30030988-9 2018 Trans-resveratrol reversed the diabetes-induced decrease in Cyp26b1 transcription on 14d and 30d and normalized Cyp3a9 transcription on 30d. Resveratrol 0-17 cytochrome P450, family 26, subfamily b, polypeptide 1 Rattus norvegicus 60-67 30030988-10 2018 Trans-resveratrol normalized the diabetes-induced increase in Rdh5, Rdh10, and Cyp3a9 protein levels, but it further increased Cyp26b1 protein level. Resveratrol 0-17 cytochrome P450, family 26, subfamily b, polypeptide 1 Rattus norvegicus 127-134 29715537-11 2018 Meanwhile the potential mechanism of resveratrol was associated with increased levels of Sirt1, CREB phosphorylation (p-CREB), CREB, BDNF and decreased levels of miR-134 in vivo and in vitro. Resveratrol 37-48 brain-derived neurotrophic factor Rattus norvegicus 133-137 21213405-8 2011 Furthermore, RSVL (final concentration 50 muM) remarkably depressed the activity of PKC in the membrane of platelets and the percentage of membrane PKC activity in total PKC activity. Resveratrol 13-17 protein kinase C iota Homo sapiens 84-87 29715537-12 2018 In conclusion, our study showed that the neuroprotective effect of resveratrol on CUMS-induced cognitive impairment may rely on activating Sirt1/miR-134 pathway and then upregulating its downstream CREB/BDNF expression in hippocampus. Resveratrol 67-78 brain-derived neurotrophic factor Rattus norvegicus 203-207 30103844-5 2018 Further studies reveal that resveratrol decreases the absorption of glutamine and glutathione content by reducing the expression of glutamine transporter ASCT2. Resveratrol 28-39 solute carrier family 1 member 5 Homo sapiens 154-159 21213405-8 2011 Furthermore, RSVL (final concentration 50 muM) remarkably depressed the activity of PKC in the membrane of platelets and the percentage of membrane PKC activity in total PKC activity. Resveratrol 13-17 protein kinase C iota Homo sapiens 148-151 29956753-10 2018 In addition, RSV induced the mRNA-decaying activity of TTP and inhibited the relative luciferase activity of baculoviral IAP repeat containing 3 (cIAP2), large tumor suppressor kinase 2 (LATS2), E2F1, and lin-28 homolog A (Lin28) in HCT116 and SNU81 cells. Resveratrol 13-16 large tumor suppressor kinase 2 Homo sapiens 154-185 21213405-8 2011 Furthermore, RSVL (final concentration 50 muM) remarkably depressed the activity of PKC in the membrane of platelets and the percentage of membrane PKC activity in total PKC activity. Resveratrol 13-17 protein kinase C iota Homo sapiens 148-151 29956753-10 2018 In addition, RSV induced the mRNA-decaying activity of TTP and inhibited the relative luciferase activity of baculoviral IAP repeat containing 3 (cIAP2), large tumor suppressor kinase 2 (LATS2), E2F1, and lin-28 homolog A (Lin28) in HCT116 and SNU81 cells. Resveratrol 13-16 large tumor suppressor kinase 2 Homo sapiens 187-192 29956753-11 2018 Therefore, RSV enhanced the inhibitory activity of TTP in HCT116 and SNU81 cells by negatively regulating cIAP2, E2F1, LATS2, and Lin28 expression. Resveratrol 11-14 large tumor suppressor kinase 2 Homo sapiens 119-124 21213405-9 2011 Taken together, these results suggested that RSVL suppressed U46619-induced platelet aggregation and PFig content partially through the inhibition of the activity of PKC in platelets. Resveratrol 45-49 protein kinase C iota Homo sapiens 166-169 30243369-11 2018 Resveratrol also increased stimulated TNF and IL-6 production with no effect on IL-10. Resveratrol 0-11 interleukin 6 Canis lupus familiaris 46-50 21261644-2 2011 We have demonstrated the existence of a plasma membrane receptor for resveratrol near the arginine-glycine-aspartate (RGD) recognition site on integrin alpha(v)beta3 that is involved in stilbene-induced apoptosis of cancer cells. Resveratrol 69-80 integrin subunit alpha V Homo sapiens 143-165 20844277-10 2011 The SIRT1 activators resveratrol and SRT1720 significantly decreased LPS-induced TNF, IL6, and IL8 gene expression and release and PTGS2 mRNA expression and resultant prostaglandin (PG) E(2) and PGF(2alpha) release from human gestational tissues. Resveratrol 21-32 sirtuin 1 Homo sapiens 4-9 30037068-0 2018 Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration. Resveratrol 173-184 sirtuin 1 Homo sapiens 19-28 30037068-2 2018 The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. Resveratrol 56-67 sirtuin 1 Homo sapiens 125-131 30037068-2 2018 The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. Resveratrol 69-72 sirtuin 1 Homo sapiens 125-131 20980646-11 2010 The oxLDL-induced alterations in levels of Bcl-2, Bax, and cytochrome c were completely normalized by resveratrol. Resveratrol 102-113 BCL2-associated X protein Mus musculus 50-53 30037068-6 2018 RSV and CR increased serum levels of Sirt-1, respectively, from 1.06 +- 0.71 ng/mL to 5.75 +- 2.98 ng/mL (p < 0.0001) and from 1.65 +- 1.81 ng/mL to 5.80 +- 2.23 ng/mL (p < 0.0001). Resveratrol 0-3 sirtuin 1 Homo sapiens 37-43 30037068-8 2018 Significant positive correlation was observed between gene expression changes of Sirt-1 and esRAGE in RSV (r = 0.86; p < 0.0001) and in CR (r = 0.71; p < 0.0001) groups, but not for the changes in serum concentrations. Resveratrol 102-105 sirtuin 1 Homo sapiens 81-87 30002278-7 2018 It is noteworthy that resveratrol strongly suppressed TNF-beta-induced activation of tumor-promoting factors (NF-kappaB, MMP-9, CXCR4) and epithelial-to-mesenchymal-transition-factors (increased vimentin and slug, decreased E-cadherin) in CRC cells. Resveratrol 22-33 lymphotoxin alpha Homo sapiens 54-62 20732460-7 2010 The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene, SirT1. Resveratrol 26-37 sirtuin 1 Homo sapiens 109-114 30002278-7 2018 It is noteworthy that resveratrol strongly suppressed TNF-beta-induced activation of tumor-promoting factors (NF-kappaB, MMP-9, CXCR4) and epithelial-to-mesenchymal-transition-factors (increased vimentin and slug, decreased E-cadherin) in CRC cells. Resveratrol 22-33 matrix metallopeptidase 9 Homo sapiens 121-126 30002278-7 2018 It is noteworthy that resveratrol strongly suppressed TNF-beta-induced activation of tumor-promoting factors (NF-kappaB, MMP-9, CXCR4) and epithelial-to-mesenchymal-transition-factors (increased vimentin and slug, decreased E-cadherin) in CRC cells. Resveratrol 22-33 C-X-C motif chemokine receptor 4 Homo sapiens 128-133 30002278-8 2018 Conclusion: Our results clearly demonstrate for the first time that resveratrol modulates the TNF-beta signaling pathway, induces apoptosis, suppresses NF-kappaB activation, epithelial-to-mesenchymal-transition (EMT), CSCs formation and chemosensitizes CRC cells to 5-FU in a tumor microenvironment. Resveratrol 68-79 lymphotoxin alpha Homo sapiens 94-102 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 154-165 sirtuin 1 Homo sapiens 61-70 29461680-5 2018 The cell apoptotic rate increased with the increasing concentration of resveratrol (0, 40, 80, 160, 320 muM), as detected by TdT-mediated dUTP nick-end labeling (TUNEL) staining and western blotting. Resveratrol 71-82 DNA nucleotidylexotransferase Homo sapiens 125-128 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 154-165 sirtuin 1 Homo sapiens 72-77 29461680-6 2018 Furthermore, the expression level of autophagy-related proteins (LC3A/B, ATG-5) decreased with the increased concentration of resveratrol, as determined by immunofluorescence and western blot analysis. Resveratrol 126-137 microtubule associated protein 1 light chain 3 alpha Homo sapiens 65-71 29845301-3 2018 Resveratrol inhibited cell proliferation and migration, and decreased the AngII-induced protein expression of alpha-smooth muscle actin (alpha-SMA), proliferating cell nuclear antigen (PCNA) and cyclin-dependent kinase 4 (CDK4). Resveratrol 0-11 proliferating cell nuclear antigen Rattus norvegicus 149-183 29845301-3 2018 Resveratrol inhibited cell proliferation and migration, and decreased the AngII-induced protein expression of alpha-smooth muscle actin (alpha-SMA), proliferating cell nuclear antigen (PCNA) and cyclin-dependent kinase 4 (CDK4). Resveratrol 0-11 proliferating cell nuclear antigen Rattus norvegicus 185-189 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 154-165 sirtuin 1 Homo sapiens 191-196 29514046-10 2018 Moreover, we show that the transcriptional activation potential of the c-Fos protein is increased in resveratrol-stimulated cells, indicating that the biological activity of c-Fos is elevated by resveratrol stimulation. Resveratrol 101-112 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 71-76 29514046-10 2018 Moreover, we show that the transcriptional activation potential of the c-Fos protein is increased in resveratrol-stimulated cells, indicating that the biological activity of c-Fos is elevated by resveratrol stimulation. Resveratrol 101-112 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 174-179 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 167-170 sirtuin 1 Homo sapiens 61-70 29514046-10 2018 Moreover, we show that the transcriptional activation potential of the c-Fos protein is increased in resveratrol-stimulated cells, indicating that the biological activity of c-Fos is elevated by resveratrol stimulation. Resveratrol 195-206 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 71-76 29514046-10 2018 Moreover, we show that the transcriptional activation potential of the c-Fos protein is increased in resveratrol-stimulated cells, indicating that the biological activity of c-Fos is elevated by resveratrol stimulation. Resveratrol 195-206 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 174-179 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 167-170 sirtuin 1 Homo sapiens 72-77 29514046-11 2018 Pharmacological and genetic experiments revealed that the protein kinase ERK1/2 is the signal transducer that connects resveratrol treatment with the c-Fos gene. Resveratrol 119-130 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 150-155 20531350-3 2010 Some of these effects are mediated through activation of the sirtuin 1 (Sirt1) enzyme, and in this study, we investigate whether the natural phytoalexin, resveratrol (RSV), which is a potent Sirt1 activator, has anti-inflammatory effects in human adipose tissue explants. Resveratrol 167-170 sirtuin 1 Homo sapiens 191-196 20531350-10 2010 CONCLUSION: This study is the first to show anti-inflammatory effects of RSV on adipokine expression and secretion in human adipose tissue in vitro through the SIRT1 pathway. Resveratrol 73-76 sirtuin 1 Homo sapiens 160-165 20610621-9 2010 Treatment of human endothelial cells with resveratrol led to an up-regulation of SOD1, SOD2, SOD3, GPx1, catalase, and GCH1. Resveratrol 42-53 glutathione peroxidase 1 Homo sapiens 99-103 29500887-9 2018 Furthermore, resveratrol, which decreases prostate cancer cell migration, inhibited TRPM7 expression and function including TGFbeta-induced cell migration and activation of TRPM7 function. Resveratrol 13-24 transient receptor potential cation channel subfamily M member 7 Homo sapiens 84-89 20651248-6 2010 Knockdown of SIRT1 expression abolished the inhibitory effect of resveratrol, and co-immunoprecipitation studies provide direct evidence of an interaction between acetylated Smad3 and SIRT1. Resveratrol 65-76 sirtuin 1 Homo sapiens 13-18 29500887-9 2018 Furthermore, resveratrol, which decreases prostate cancer cell migration, inhibited TRPM7 expression and function including TGFbeta-induced cell migration and activation of TRPM7 function. Resveratrol 13-24 transient receptor potential cation channel subfamily M member 7 Homo sapiens 173-178 29500887-10 2018 Together, these results suggest that Mg2+ influx via TRPM7 promotes cell migration by inducing EMT in prostate cancer cells and resveratrol negatively modulates TRPM7 function thereby inhibiting prostate cancer metastasis. Resveratrol 128-139 transient receptor potential cation channel subfamily M member 7 Homo sapiens 161-166 20622002-0 2010 Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD. Resveratrol 0-11 microRNA 155 Homo sapiens 36-43 20622002-7 2010 Finally, we show that resveratrol impairs the upregulation of miR-155 by LPS in a miR-663-dependent manner. Resveratrol 22-33 microRNA 155 Homo sapiens 62-69 20622002-8 2010 Given the role of miR-155 in the innate immune response and the fact that it is upregulated in many cancers, our results suggest that manipulating miR-663 levels may help to optimize the use of resveratrol as both an anti-inflammatory and anticancer agent against malignancies associated with high levels of miR-155. Resveratrol 194-205 microRNA 155 Homo sapiens 308-315 20542495-6 2010 The induction of mitochondrial SOD2 by resveratrol was mediated through the activation of the PI3K/Akt and GSK-3beta/beta-catenin signaling pathways. Resveratrol 39-50 catenin (cadherin associated protein), beta 1 Mus musculus 117-129 20238161-4 2010 It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice. Resveratrol 16-27 forkhead box O3 Mus musculus 119-125 20631324-0 2010 Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. Resveratrol 0-11 BRCA1 DNA repair associated Homo sapiens 45-51 20519497-6 2010 Oxidative stress and the Sirt1 activator resveratrol are thought to promote FoxO1 deacetylation and nuclear retention, thus increasing its activity. Resveratrol 41-52 sirtuin 1 Homo sapiens 25-30 20519497-9 2010 In contrast, the effect of resveratrol was independent of FoxO1 acetylation and its phosphorylation on Ser-253 and Thr-24, suggesting that resveratrol acts on FoxO1 in a Sirt1- and Akt-independent manner. Resveratrol 139-150 sirtuin 1 Homo sapiens 170-175 20712904-9 2010 Resveratrol had no effect on LPS-stimulated phosphorylation of ERK1/2 and p38 in microglia and astrocytes, but slightly inhibited LPS-stimulated phosphorylation of JNK in astrocytes. Resveratrol 0-11 mitogen-activated protein kinase 8 Mus musculus 164-167 20306310-4 2010 These studies show that the beneficial effects of resveratrol are not only limited to its antioxidant and anti-inflammatory action but also include activation of sirtuin 1 (SIRT1) and vitagenes, which can prevent the deleterious effects triggered by oxidative stress. Resveratrol 50-61 sirtuin 1 Homo sapiens 162-171 20306310-4 2010 These studies show that the beneficial effects of resveratrol are not only limited to its antioxidant and anti-inflammatory action but also include activation of sirtuin 1 (SIRT1) and vitagenes, which can prevent the deleterious effects triggered by oxidative stress. Resveratrol 50-61 sirtuin 1 Homo sapiens 173-178 20306310-5 2010 In fact, SIRT1 activation by resveratrol is gaining importance in the development of innovative treatment strategies for stroke and other neurodegenerative disorders. Resveratrol 29-40 sirtuin 1 Homo sapiens 9-14 20504360-0 2010 Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. Resveratrol 0-11 insulin like growth factor 1 receptor Homo sapiens 117-123 20504360-6 2010 Treatment with resveratrol suppressed IGF-1R protein levels and concurrently attenuated the downstream Akt/Wnt signaling pathways that play a critical role in cell proliferation. Resveratrol 15-26 insulin like growth factor 1 receptor Homo sapiens 38-44 20504360-9 2010 Our data suggests that resveratrol not only suppresses cell proliferation by inhibiting IGF-1R and its downstream signaling pathways similar to that of IGF-1R siRNA but also enhances apoptosis via activation of the p53 pathway. Resveratrol 23-34 insulin like growth factor 1 receptor Homo sapiens 88-94 20504360-9 2010 Our data suggests that resveratrol not only suppresses cell proliferation by inhibiting IGF-1R and its downstream signaling pathways similar to that of IGF-1R siRNA but also enhances apoptosis via activation of the p53 pathway. Resveratrol 23-34 insulin like growth factor 1 receptor Homo sapiens 152-158 20504360-10 2010 CONCLUSIONS: For the first time, we report that resveratrol suppresses colon cancer cell proliferation and elevates apoptosis even in the presence of IGF-1 via suppression of IGF-1R/Akt/Wnt signaling pathways and activation of p53, suggesting its potential role as a chemotherapeutic agent. Resveratrol 48-59 insulin like growth factor 1 receptor Homo sapiens 175-181 20372816-4 2010 Resveratrol markedly reduced RAGE expression via peroxisome proliferator-activated receptor (PPAR) gamma but not PPARalpha or AMP-activated protein kinase. Resveratrol 0-11 advanced glycosylation end-product specific receptor Homo sapiens 29-33 20372816-7 2010 Collectively, our results indicate that resveratrol prevents the impairment of AGE on macrophage lipid homeostasis partially by suppressing RAGE via PPARgamma activation, which might provide new insight into the protective role of resveratrol against diabetic atherosclerosis. Resveratrol 40-51 advanced glycosylation end-product specific receptor Homo sapiens 140-144 22966330-6 2010 When treated with resveratrol, glioma cells stably expressing GFP fused to LC3, recruited more GFP-LC3-labeled autophagosomes, and the percentage of cells with GFP-LC3-labeled autophagosomes increased. Resveratrol 18-29 microtubule associated protein 1 light chain 3 alpha Homo sapiens 75-78 22966330-6 2010 When treated with resveratrol, glioma cells stably expressing GFP fused to LC3, recruited more GFP-LC3-labeled autophagosomes, and the percentage of cells with GFP-LC3-labeled autophagosomes increased. Resveratrol 18-29 microtubule associated protein 1 light chain 3 alpha Homo sapiens 99-102 22966330-6 2010 When treated with resveratrol, glioma cells stably expressing GFP fused to LC3, recruited more GFP-LC3-labeled autophagosomes, and the percentage of cells with GFP-LC3-labeled autophagosomes increased. Resveratrol 18-29 microtubule associated protein 1 light chain 3 alpha Homo sapiens 99-102 19959541-8 2010 Although resveratrol attenuated the activation of mTOR complex 1, low-dose resveratrol significantly induced the expression of Rictor, a component of mTOR complex 2, and activated its downstream survival kinase Akt (Ser 473). Resveratrol 9-20 mechanistic target of rapamycin kinase Rattus norvegicus 50-54 19959541-8 2010 Although resveratrol attenuated the activation of mTOR complex 1, low-dose resveratrol significantly induced the expression of Rictor, a component of mTOR complex 2, and activated its downstream survival kinase Akt (Ser 473). Resveratrol 75-86 mechanistic target of rapamycin kinase Rattus norvegicus 150-154 19959541-9 2010 Resveratrol-induced Rictor was found to bind with mTOR. Resveratrol 0-11 mechanistic target of rapamycin kinase Rattus norvegicus 50-54 19959541-11 2010 CONCLUSION: Our results indicate that at lower dose, resveratrol-mediated cell survival is, in part, mediated through the induction of autophagy involving the mTOR-Rictor survival pathway. Resveratrol 53-64 mechanistic target of rapamycin kinase Rattus norvegicus 159-163 20026400-8 2010 Similarly, PTP1B(-/-) brown adipocytes were protected against resveratrol-induced apoptosis. Resveratrol 62-73 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 11-16 20068143-14 2010 Glucose- and palmitate-mediated effects on NAMPT and SIRT1 were prevented by resveratrol in vitro. Resveratrol 77-88 sirtuin 1 Homo sapiens 53-58 20960276-7 2010 Resveratrol treatment increased the expression of SIRT1 and the secretion of NO. Resveratrol 0-11 sirtuin 1 Homo sapiens 50-55 20960276-8 2010 After interfering the expression of SIRT1 using SIRT1 siRNA, the effects of resveratrol on the NO secretion induced by insulin was impaired. Resveratrol 76-87 sirtuin 1 Homo sapiens 36-41 20960276-8 2010 After interfering the expression of SIRT1 using SIRT1 siRNA, the effects of resveratrol on the NO secretion induced by insulin was impaired. Resveratrol 76-87 sirtuin 1 Homo sapiens 48-53 20960276-10 2010 Resveratrol can improve the NO stimulating function of insulin in high glucose cultured HUVEC in SIRT1-dependent manner. Resveratrol 0-11 sirtuin 1 Homo sapiens 97-102 20002210-7 2010 Resveratrol-treated DCs lost the ability to produce interleukin (IL)-12p70 after activation, but had an increased ability to produce IL-10. Resveratrol 0-11 interleukin 10 Homo sapiens 133-138 20002210-9 2010 Furthermore, treated cells were able to generate allogeneic IL-10-secreting T cells, but were not competent in inducing FoxP3 expression These tolerogenic effects are probably associated with the effect of resveratrol on multiple molecular targets through which it interferes with DC differentiation and nuclear factor (NF)-kappaB translocation. Resveratrol 206-217 interleukin 10 Homo sapiens 60-65 19810103-0 2010 Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. Resveratrol 0-11 metastasis associated 1 Homo sapiens 84-88 20379461-9 2010 RESULTS: In both in vivo and in vitro OIR, the expression of iNOS antibody and mRNA was increased and of eNOS and nNOS were reduced in the resveratrol-treated group. Resveratrol 139-150 nitric oxide synthase 3 Rattus norvegicus 105-109 20379461-9 2010 RESULTS: In both in vivo and in vitro OIR, the expression of iNOS antibody and mRNA was increased and of eNOS and nNOS were reduced in the resveratrol-treated group. Resveratrol 139-150 nitric oxide synthase 1 Rattus norvegicus 114-118 20089784-10 2010 Our experiments identify MRP2 and BCRP as the 2 apical transporters involved in the efflux of resveratrol conjugates. Resveratrol 94-105 ATP binding cassette subfamily C member 2 Rattus norvegicus 25-29 28420272-0 2018 Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro. Resveratrol 0-11 sirtuin 1 Homo sapiens 72-77 28420272-1 2018 OBJECTIVE: By assessing silent mating-type information regulation 2 homolog 1 (SIRT1) nucleocytoplasmic shuttling and reactive oxygen species (ROS) levels in peripheral blood mononuclear cells (PBMCs), this study aimed to explore the role of SIRT1 in premature infants after exposure to hyperoxia and assess the protective effects of resveratrol (Res). Resveratrol 334-345 sirtuin 1 Homo sapiens 79-84 28420272-1 2018 OBJECTIVE: By assessing silent mating-type information regulation 2 homolog 1 (SIRT1) nucleocytoplasmic shuttling and reactive oxygen species (ROS) levels in peripheral blood mononuclear cells (PBMCs), this study aimed to explore the role of SIRT1 in premature infants after exposure to hyperoxia and assess the protective effects of resveratrol (Res). Resveratrol 347-350 sirtuin 1 Homo sapiens 79-84 19940103-5 2010 After resveratrol treatment, the percentage of CD4(+) T cells in mesenteric lymph nodes (MLN) of colitis mice was restored to normal levels, and there was a decrease in these cells in the colon lamina propria (LP). Resveratrol 6-17 CD4 antigen Mus musculus 47-50 20102704-0 2010 SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Resveratrol 100-111 sirtuin 1 Homo sapiens 0-5 20102704-7 2010 Pre-treatment of endothelial cells with resveratrol significantly attenuated the CSE- and oxidant-mediated SIRT1 levels and eNOS acetylation. Resveratrol 40-51 sirtuin 1 Homo sapiens 107-112 19928762-0 2010 Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. Resveratrol 0-11 sirtuin 1 Homo sapiens 75-80 20067468-7 2010 KEY RESULTS: Resveratrol significantly aggravated damage from indomethacin-induced gastric ulcers, and delayed healing, as shown by increased DS and MPO activity. Resveratrol 13-24 myeloperoxidase Mus musculus 149-152 19968965-3 2010 Here, we show that diverse vasoprotective stimuli including an atheroprotective shear stress waveform, simvastatin, and resveratrol induce the expression of KLF4 in cultured human endothelial cells. Resveratrol 120-131 Kruppel like factor 4 Homo sapiens 157-161 19968965-4 2010 We further demonstrate that the induction of KLF4 by resveratrol and atheroprotective shear stress occurs via a MEK5/MEF2-dependent signaling pathway. Resveratrol 53-64 Kruppel like factor 4 Homo sapiens 45-49 20023410-4 2010 Our data indicate that the activation of Sirtuin-1 (by the pharmacological agent resveratrol and/or genetic means) per se ignites autophagy, and that Sirtuin-1 is required for the autophagic response to nutrient deprivation, in both human and nematode cells, but not for autophagy triggered by downstream signals such as the inhibition of mTOR or p53. Resveratrol 81-92 sirtuin 1 Homo sapiens 41-50 20023410-5 2010 Since the life spanextending effects of Sirtuin-1 activators are lost in autophagy-deficient C. elegans, our results suggest that caloric restriction and resveratrol extend longevity, at least in experimental settings, by activating autophagy. Resveratrol 154-165 sirtuin 1 Homo sapiens 40-49 21364612-0 2010 Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Resveratrol 24-35 sirtuin 1 Homo sapiens 66-75 21364612-3 2010 The knockdown or knockout of Sirtuin-1 prevented the induction of autophagy by resveratrol and by nutrient deprivation in human cells as well as by dietary restriction in C. elegans. Resveratrol 79-90 sirtuin 1 Homo sapiens 29-38 21364612-6 2010 Along similar lines, resveratrol and dietary restriction only prolonged the lifespan of autophagy-proficient nematodes, whereas these beneficial effects on longevity were abolished by the knockdown of the essential autophagic modulator Beclin-1. Resveratrol 21-32 beclin 1 Homo sapiens 236-244 20160399-2 2010 A natural polyphenolic compound resveratrol is also shown to increases SIRT1 activity and extends lifespan. Resveratrol 32-43 sirtuin 1 Homo sapiens 71-76 19796711-4 2010 Our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (Jurkat, SUP-B15, and Kasumi-1), and reducing the phosphorylation of STAT3, meanwhile modulating the expression of Bcl-2 and Bax. Resveratrol 23-34 BCL2-associated X protein Mus musculus 268-271 19843076-1 2009 Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are thought to be mediated in large by the activation of the NAD(+)-dependent protein deacetylase SIRT1. Resveratrol 0-11 sirtuin 1 Sus scrofa 187-192 19843076-2 2009 Although resveratrol has been claimed to be a bona fide SIRT1 activator using a peptide substrate (Fluor de Lys-SIRT1 peptide substrate), recent reports indicate that this finding might be an experimental artifact and need to be clarified. Resveratrol 9-20 sirtuin 1 Sus scrofa 56-61 19843076-2 2009 Although resveratrol has been claimed to be a bona fide SIRT1 activator using a peptide substrate (Fluor de Lys-SIRT1 peptide substrate), recent reports indicate that this finding might be an experimental artifact and need to be clarified. Resveratrol 9-20 sirtuin 1 Sus scrofa 112-117 19843076-5 2009 In consequence, our data challenge the overall utility of resveratrol as a pharmacological tool to directly activate SIRT1. Resveratrol 58-69 sirtuin 1 Sus scrofa 117-122 28936721-0 2018 A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation. Resveratrol 8-19 KRAS proto-oncogene, GTPase Homo sapiens 102-106 28936721-7 2018 These results suggest that the resveratrol derivative inhibits the growth of HCT116 cell spheroids via inhibition of an oncogenic KRAS-mediated signaling pathway. Resveratrol 31-42 KRAS proto-oncogene, GTPase Homo sapiens 130-134 29578301-4 2018 The results show that RSV supplementation improves muscle atrophy and muscle function, attenuates the increase in ubiquitin and muscle RING-finger protein-1 (MuRF-1), and simultaneously attenuates LC3-II and cleaved caspase-3 in the skeletal muscle of diabetic mice. Resveratrol 22-25 tripartite motif-containing 63 Mus musculus 128-156 29578301-4 2018 The results show that RSV supplementation improves muscle atrophy and muscle function, attenuates the increase in ubiquitin and muscle RING-finger protein-1 (MuRF-1), and simultaneously attenuates LC3-II and cleaved caspase-3 in the skeletal muscle of diabetic mice. Resveratrol 22-25 tripartite motif-containing 63 Mus musculus 158-164 28989083-0 2018 Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress. Resveratrol 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 26-30 28989083-5 2018 Resveratrol is a potent activator of AMPK suggesting it may have therapeutic potential against AD. Resveratrol 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 37-41 28989083-6 2018 Therefore, we will test the hypothesis that the AMPK activator resveratrol protects against Abeta mediated neuronal impairment (inflammation and oxidative stress) in hNSCs. Resveratrol 63-74 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 48-52 28989083-8 2018 Co-treatment with resveratrol significantly abrogated the Abeta-mediated effects in hNSCs, and was effectively blocked by the addition of the AMPK-specific antagonist (Compound C). Resveratrol 18-29 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 142-146 28989083-9 2018 These results suggest the neuroprotective effects of resveratrol are mediated by an AMPK-dependent pathway. Resveratrol 53-64 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 84-88 28989083-14 2018 Furthermore, hNSCs co-treated with resveratrol were significantly rescued from Abeta-induced oxidative stress, which correlated with reversal of the Abeta-induced mRNA decrease in oxidative defense genes (SOD-1, NRF2, Gpx1, Catalase, GSH and HO-1). Resveratrol 35-46 glutathione peroxidase 1 Homo sapiens 218-222 28989083-15 2018 Taken together, these novel findings show that activation of AMPK-dependent signaling by resveratrol rescues Abeta-mediated neurotoxicity in hNSCs, and provides evidence supporting a neuroprotective role for AMPK activating drugs in Abeta-related diseases such as AD. Resveratrol 89-100 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 61-65 29710384-5 2018 Resveratrol (50 mg L-1 ) was administered in drinking water from weaning to 3 months of age. Resveratrol 0-11 ribosomal protein L4 Rattus norvegicus 19-22 29854071-7 2018 Moreover, RSV or N-acetyl-L-cysteine (NAC) administration or miR-21 knockdown in PSCs reduced the invasion and migration of PCCs in coculture, and the effects of RSV were partly reversed by miR-21 upregulation. Resveratrol 162-165 X-linked Kx blood group Homo sapiens 38-41 29713468-16 2018 Dietary resveratrol regulates placental antioxidant gene expression by the Keap1-Nrf2 pathway and Sirt1 in placenta. Resveratrol 8-19 sirtuin 1 Homo sapiens 98-103 29849897-7 2018 Furthermore, resveratrol, an activator of SIRT1, decreased the acetylation of BMAL1 and inhibited its binding with CRY1, thereby reversing the impaired antioxidative activity induced by 6-OHDA. Resveratrol 13-24 sirtuin 1 Homo sapiens 42-47 29849897-7 2018 Furthermore, resveratrol, an activator of SIRT1, decreased the acetylation of BMAL1 and inhibited its binding with CRY1, thereby reversing the impaired antioxidative activity induced by 6-OHDA. Resveratrol 13-24 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 78-83 29624568-11 2018 In addition, resveratrol increased expression of Sirt1 and PGC-1alpha in MC3T3-E1 cells treated with LPS. Resveratrol 13-24 sirtuin 1 Sus scrofa 49-54 29477771-8 2018 Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 94-99 29477771-9 2018 In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Resveratrol 13-24 SRY-box transcription factor 2 Homo sapiens 35-39 29339083-6 2018 We also treated some REC with resveratrol to determine if resveratrol could increase miR15a expression, since resveratrol is protective to the diabetic retina. Resveratrol 58-69 microRNA 15a Mus musculus 85-91 29339083-6 2018 We also treated some REC with resveratrol to determine if resveratrol could increase miR15a expression, since resveratrol is protective to the diabetic retina. Resveratrol 58-69 microRNA 15a Mus musculus 85-91 29339083-8 2018 Treatment with resveratrol increased miR15a expression in REC grown in high glucose. Resveratrol 15-26 microRNA 15a Mus musculus 37-43 28975701-7 2018 Treatment with resveratrol, a SIRT1 agonist, can also reverse this ROS-induced adipogenesis/osteogenesis lineage imbalance. Resveratrol 15-26 sirtuin 1 Homo sapiens 30-35 29257276-6 2018 Resveratrol pretreatment also inhibited the activation of NLRP3 and caspase-1, and reduced the production of inflammatory cytokines and ROS. Resveratrol 0-11 caspase 1 Rattus norvegicus 68-77 28676015-0 2018 Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging. Resveratrol 11-22 sirtuin 1 Homo sapiens 48-53 29371621-6 2018 Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage. Resveratrol 59-70 phospholipase A2 group IIA Homo sapiens 374-378 29371621-6 2018 Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage. Resveratrol 221-232 phospholipase A2 group IIA Homo sapiens 374-378 29096276-3 2018 However, both the durations of resveratrol treatment (6 h or 24 h) significantly increased the expression levels of SIRT1. Resveratrol 31-42 sirtuin 1 Bos taurus 116-121 29316653-5 2018 Resveratrol and valproate restored the acetylation of histone H3 (K9/18), and they reduced the RelA(K310) acetylation and the Bim level in neurons exposed to OGD. Resveratrol 0-11 BCL2-like 11 (apoptosis facilitator) Mus musculus 126-129 29492205-5 2018 Furthermore, it was proved that resveratrol can activate the LKB1/AMPK/mTOR/p70s6k pathway in vivo and in vitro, and the LKB1/AMPK/mTOR/p70s6k pathway plays a vital role in activating the autophagic flux mediated by resveratrol in PC12 cells. Resveratrol 32-43 mechanistic target of rapamycin kinase Rattus norvegicus 71-75 29492205-5 2018 Furthermore, it was proved that resveratrol can activate the LKB1/AMPK/mTOR/p70s6k pathway in vivo and in vitro, and the LKB1/AMPK/mTOR/p70s6k pathway plays a vital role in activating the autophagic flux mediated by resveratrol in PC12 cells. Resveratrol 32-43 mechanistic target of rapamycin kinase Rattus norvegicus 131-135 29492205-5 2018 Furthermore, it was proved that resveratrol can activate the LKB1/AMPK/mTOR/p70s6k pathway in vivo and in vitro, and the LKB1/AMPK/mTOR/p70s6k pathway plays a vital role in activating the autophagic flux mediated by resveratrol in PC12 cells. Resveratrol 216-227 mechanistic target of rapamycin kinase Rattus norvegicus 131-135 29492205-6 2018 Thus, resveratrol enables to ameliorate neuronal autophagic flux via the LKB1/AMPK/mTOR/p70s6k pathway to alleviate apoptosis, and finally ameliorating functional recovery after acute SCI in SD rats. Resveratrol 6-17 mechanistic target of rapamycin kinase Rattus norvegicus 83-87 28770830-8 2018 Furthermore, manganese superoxide dismutase (SOD) activity, ATP content, mitochondrial DNA copy number, mitochondrial membrane potential and the expression of nuclear respiration factor (NRF) were all significantly increased in diabetic hearts by RSV administration, whereas the levels of malondialdehvde (MDA) and uncoupling protein 2 (UCP2) were significantly decreased. Resveratrol 247-250 uncoupling protein 2 Rattus norvegicus 315-335 28770830-8 2018 Furthermore, manganese superoxide dismutase (SOD) activity, ATP content, mitochondrial DNA copy number, mitochondrial membrane potential and the expression of nuclear respiration factor (NRF) were all significantly increased in diabetic hearts by RSV administration, whereas the levels of malondialdehvde (MDA) and uncoupling protein 2 (UCP2) were significantly decreased. Resveratrol 247-250 uncoupling protein 2 Rattus norvegicus 337-341 28770830-9 2018 Moreover, RSV administration significantly activated SIRT1 expression and increased PGC-1alpha deacetylation. Resveratrol 10-13 sirtuin 1 Sus scrofa 53-58 29183727-0 2018 Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells. Resveratrol 0-11 cytochrome b-245 beta chain Homo sapiens 108-117 29183727-4 2018 Semiquantitative RT-PCR showed that co-treatment with RA and resveratrol strongly enhanced transcription of the gp91-phox compared with those of the RA-treatment only. Resveratrol 61-72 cytochrome b-245 beta chain Homo sapiens 112-121 30537742-5 2018 The effects of RSV on the expression levels of LD-associated genes (ATF6, Fsp27beta/CIDEC, CREBH, and PLIN1) were measured by qRT-PCR and western blot assays, followed by KD or overexpression of SIRT1 and ATF6 with small interfering RNAs or overexpressed plasmids, respectively. Resveratrol 15-18 cAMP responsive element binding protein 3-like 3 Mus musculus 91-96 30537742-8 2018 RSV notably activated SIRT1 expression and decreased the expression levels of ATF6, Fsp27beta/CIDEC, CREBH, and PLIN1, which are associated with LD accumulation. Resveratrol 0-3 cAMP responsive element binding protein 3-like 3 Mus musculus 101-106 29723857-9 2018 Moreover, resveratrol activated AMPK and JNK1, thereby suppressing mTOR and its downstream effectors p70S6K1 and 4EBP1, as well as disrupting the Beclin1-Bcl-2 complex. Resveratrol 10-21 mechanistic target of rapamycin kinase Rattus norvegicus 67-71 28385009-2 2017 In this study, the anticarcinogenic effects of resveratrol against hepatitis B virus (HBV)-induced HCC were investigated by using HBV X-protein-overexpressing Huh7 (Huh7-HBx) human hepatoma cells. Resveratrol 47-58 MIR7-3 host gene Homo sapiens 159-163 28385009-2 2017 In this study, the anticarcinogenic effects of resveratrol against hepatitis B virus (HBV)-induced HCC were investigated by using HBV X-protein-overexpressing Huh7 (Huh7-HBx) human hepatoma cells. Resveratrol 47-58 MIR7-3 host gene Homo sapiens 165-173 28385009-8 2017 Collectively, the results indicate that resveratrol inhibits Huh7-HBx proliferation by decreasing cyclin D1 expression through blockade of Akt signaling. Resveratrol 40-51 MIR7-3 host gene Homo sapiens 61-69 28983625-7 2017 This demonstrated that resveratrol inhibited the PI3K/AKT pathway by SIRT1 activation. Resveratrol 23-34 sirtuin 1 Homo sapiens 69-74 28983625-9 2017 These findings suggested that resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT pathway in HCC cells. Resveratrol 30-41 sirtuin 1 Homo sapiens 87-92 29340064-5 2017 After treatment with resveratrol, the expression of related Wnt/beta-catenin signaling pathway target genes, such as beta-catenin, c-myc, cyclin D1, MMP-2 and MMP-9, was downregulated and an increased E-cadherin level was observed as well. Resveratrol 21-32 matrix metallopeptidase 9 Homo sapiens 159-164 29095837-1 2017 While Lymphotoxin alpha (TNF-beta), a product of lymphocytes, is known to play a pivotal role in inflammatory joint environment, resveratrol has been shown to possess anti-inflammatory and chondroprotective effects via activation of the histondeacetylase Sirt1. Resveratrol 129-140 sirtuin 1 Homo sapiens 255-260 29095837-2 2017 Whether TNF-beta induction of inflammatory pathways in primary human chondrocytes (PCH) can be modulated by resveratrol, was investigated. Resveratrol 108-119 lymphotoxin alpha Homo sapiens 8-16 29095837-4 2017 We found that resveratrol suppressed, similar to anti-TNF-beta, TNF-beta-induced increased adhesiveness in an inflammatory microenvironment of T-lymphocytes and PCH. Resveratrol 14-25 lymphotoxin alpha Homo sapiens 64-72 29095837-5 2017 In contrast, knockdown of Sirt1 by mRNA abolished the inhibitory effects of resveratrol on the TNF-beta-induced adhesiveness, suggesting the essential role of this enzyme for resveratrol-mediated anti-inflammatory signaling. Resveratrol 76-87 sirtuin 1 Homo sapiens 26-31 29095837-5 2017 In contrast, knockdown of Sirt1 by mRNA abolished the inhibitory effects of resveratrol on the TNF-beta-induced adhesiveness, suggesting the essential role of this enzyme for resveratrol-mediated anti-inflammatory signaling. Resveratrol 76-87 lymphotoxin alpha Homo sapiens 95-103 29095837-5 2017 In contrast, knockdown of Sirt1 by mRNA abolished the inhibitory effects of resveratrol on the TNF-beta-induced adhesiveness, suggesting the essential role of this enzyme for resveratrol-mediated anti-inflammatory signaling. Resveratrol 175-186 sirtuin 1 Homo sapiens 26-31 29095837-5 2017 In contrast, knockdown of Sirt1 by mRNA abolished the inhibitory effects of resveratrol on the TNF-beta-induced adhesiveness, suggesting the essential role of this enzyme for resveratrol-mediated anti-inflammatory signaling. Resveratrol 175-186 lymphotoxin alpha Homo sapiens 95-103 29095837-8 2017 Moreover, resveratrol reversed the TNF-beta-, NAM-, T-lymphocytes-induced up-regulation of various NF-kappaB-regulated gene products. Resveratrol 10-21 lymphotoxin alpha Homo sapiens 35-43 29095837-9 2017 Down-regulation of Sirt1 by mRNA interference abrogated the effect of resveratrol on TNF-beta-induced effects. Resveratrol 70-81 sirtuin 1 Homo sapiens 19-24 29095837-9 2017 Down-regulation of Sirt1 by mRNA interference abrogated the effect of resveratrol on TNF-beta-induced effects. Resveratrol 70-81 lymphotoxin alpha Homo sapiens 85-93 29095837-10 2017 Ultrastructural and cell viability assay investigations revealed that resveratrol revoked TNF-beta-induced dose-dependent degradative/apoptotic morphological changes, cell viability and proliferation in PCH. Resveratrol 70-81 lymphotoxin alpha Homo sapiens 90-98 29095837-11 2017 Taken together, suppression of TNF-beta-induced inflammatory microenvironment in PCH by resveratrol/Sirt1 might be a novel therapeutic approach for targeting inflammation during rheumatoid arthritis. Resveratrol 88-99 lymphotoxin alpha Homo sapiens 31-39 29118980-5 2017 Results: Our results show that SIRT1 activators resveratrol and BML-278 increased H3K9 methylation and suppressed H3K9 acetylation in both the paternal and maternal pronucleus. Resveratrol 48-59 sirtuin 1 Homo sapiens 31-36 27256583-0 2017 Resveratrol suppressed seizures by attenuating IL-1beta, IL1-Ra, IL-6, and TNF-alpha in the hippocampus and cortex of kindled mice. Resveratrol 0-11 interleukin 1 receptor antagonist Mus musculus 57-63 29138567-0 2017 Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/beta-catenin pathway in rats. Resveratrol 0-11 brain-derived neurotrophic factor Rattus norvegicus 143-147 29073244-0 2017 Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/beta-catenin signaling pathway mediated by Sirt1. Resveratrol 0-11 sirtuin 1 Homo sapiens 124-129 29073244-5 2017 We found that 10 muM resveratrol improved the proliferation of porcine PSCs, increased the expression of A-beta-catenin (active beta-catenin), Pcna, C-Myc, Bcl-2 and sirtuin-1 (Sirt1), and decreased the expression of P53, Caspase3. Resveratrol 21-32 sirtuin 1 Homo sapiens 166-175 29073244-5 2017 We found that 10 muM resveratrol improved the proliferation of porcine PSCs, increased the expression of A-beta-catenin (active beta-catenin), Pcna, C-Myc, Bcl-2 and sirtuin-1 (Sirt1), and decreased the expression of P53, Caspase3. Resveratrol 21-32 sirtuin 1 Homo sapiens 177-182 29073244-7 2017 The utilization of Dickkopf-related protein 1 (DKK1, Wnt signaling pathway inhibitor) and nicotinamide (Sirt1 inhibitor) suggested that resveratrol regulated cell proliferation by controlling Wnt signaling pathway and this effect was mediated by Sirt1. Resveratrol 136-147 sirtuin 1 Homo sapiens 104-109 29073244-7 2017 The utilization of Dickkopf-related protein 1 (DKK1, Wnt signaling pathway inhibitor) and nicotinamide (Sirt1 inhibitor) suggested that resveratrol regulated cell proliferation by controlling Wnt signaling pathway and this effect was mediated by Sirt1. Resveratrol 136-147 sirtuin 1 Homo sapiens 246-251 28823883-3 2017 The objective of the present study is to investigate the inhibition of resveratrol on neurosteroidogenic enzymes rat 5alpha-reductase 1 (SRD5A1), 3alpha-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RDH2). Resveratrol 71-82 aldo-keto reductase family 1, member C14 Rattus norvegicus 146-181 28823883-3 2017 The objective of the present study is to investigate the inhibition of resveratrol on neurosteroidogenic enzymes rat 5alpha-reductase 1 (SRD5A1), 3alpha-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RDH2). Resveratrol 71-82 aldo-keto reductase family 1, member C14 Rattus norvegicus 183-189 28823883-4 2017 The IC50 values of resveratrol on SRD5A1, AKR1C9, and RDH2 were >100muM, 0.436+-0.070muM, and 4.889+-0.062muM, respectively. Resveratrol 19-30 aldo-keto reductase family 1, member C14 Rattus norvegicus 42-48 28823883-5 2017 Resveratrol competitively inhibited rat AKR1C9 and RDH2 against steroid substrates. Resveratrol 0-11 aldo-keto reductase family 1, member C14 Rattus norvegicus 40-46 28455791-4 2017 Resveratrol abolished HSC-induced angiogenesis and suppressed ROS production and IL-6 and CXCR4 receptor expression in HepG2 cells by down-regulating Gli-1 expression. Resveratrol 0-11 C-X-C motif chemokine receptor 4 Homo sapiens 90-95 28455791-4 2017 Resveratrol abolished HSC-induced angiogenesis and suppressed ROS production and IL-6 and CXCR4 receptor expression in HepG2 cells by down-regulating Gli-1 expression. Resveratrol 0-11 GLI family zinc finger 1 Homo sapiens 150-155 28523759-9 2017 This lower SULT1A1 activity resulted in an increased antilipolytic effect of resveratrol on adipocytes, as demonstrated by lower glycerol accumulation, which could be attributed to lower activity of the lipolytic protein, perilipin. Resveratrol 77-88 perilipin 1 Homo sapiens 222-231 28608449-0 2017 Resveratrol suppresses lipoprotein-associated phospholipase A2 expression by reducing oxidative stress in macrophages and animal models. Resveratrol 0-11 phospholipase A2 group VII Homo sapiens 23-62 28608449-3 2017 Here, we investigated the effects of resveratrol on Lp-PLA2 expression in vitro and in vivo and explored the underlying mechanisms. Resveratrol 37-48 phospholipase A2 group VII Homo sapiens 52-59 28608449-5 2017 Resveratrol suppressed Lp-PLA2 expression and reduced inflammation; lipopolysaccharide (LPS, 1 mug/mL), tumor necrosis factor-alpha (TNF-alpha, 10 ng/mL) and reactive oxygen species (ROS) were employed to stimulate an increase in Lp-PLA2 expression and ROS levels, and the stimulation was inhibited by resveratrol (50 muM) and other antioxidants. Resveratrol 0-11 phospholipase A2 group VII Homo sapiens 23-30 28608449-5 2017 Resveratrol suppressed Lp-PLA2 expression and reduced inflammation; lipopolysaccharide (LPS, 1 mug/mL), tumor necrosis factor-alpha (TNF-alpha, 10 ng/mL) and reactive oxygen species (ROS) were employed to stimulate an increase in Lp-PLA2 expression and ROS levels, and the stimulation was inhibited by resveratrol (50 muM) and other antioxidants. Resveratrol 0-11 phospholipase A2 group VII Homo sapiens 230-237 28849139-7 2017 The resveratrol treatment significantly inhibited the invasive ability of RA FLS (P<0.01) and reduced MMP1 and MMP13 expression (P<0.01). Resveratrol 4-15 matrix metallopeptidase 13 Rattus norvegicus 114-119 28849139-9 2017 Resveratrol also reduced the swelling and damage and decreased MMP1 and MMP13 expression levels in CIA rats (P<0.01). Resveratrol 0-11 matrix metallopeptidase 13 Rattus norvegicus 72-77 28849139-10 2017 The resveratrol-induced upregulation of Sirt1 in RA FLS may significantly inhibit the invasion of these cells and reduce the degree of joint damage, which may be mediated through the inhibition of MMP1 and MMP13 expression. Resveratrol 4-15 matrix metallopeptidase 13 Rattus norvegicus 206-211 29065794-8 2017 Resveratrol also reduced cell viability, altered the expression of apoptotic markers (Bax and Bcl2), and increased expression of gamma-H2A.x (indicative marker of DNA fragmentation) and p53 (a critical DNA damage response protein). Resveratrol 0-11 BCL2-associated X protein Mus musculus 86-89 28947831-0 2017 Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox. Resveratrol 0-11 nuclear receptor subfamily 1 group I member 3 Homo sapiens 60-92 28545897-5 2017 Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-gamma, interleukin (IL)-5, IL-33, and tumor necrosis factor-alpha levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability. Resveratrol 10-21 interleukin 33 Mus musculus 116-121 28545897-5 2017 Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-gamma, interleukin (IL)-5, IL-33, and tumor necrosis factor-alpha levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability. Resveratrol 10-21 claudin 5 Mus musculus 200-209 28815614-5 2017 Resveratrol is a potent activator of SIRT1, and thus may mimic caloric restriction to prevent diseases of aging. Resveratrol 0-11 sirtuin 1 Homo sapiens 37-42 27578011-9 2017 Resveratrol (20 and 40 mg/kg) treatment to B6 and BTBR mice showed substantial induction of Foxp3+ and reduction of T-bet+, GATA-3+, and IL-17A+ expression in CD4+ cells when compared with the respective control groups. Resveratrol 0-11 T-box 21 Mus musculus 116-121 27578011-9 2017 Resveratrol (20 and 40 mg/kg) treatment to B6 and BTBR mice showed substantial induction of Foxp3+ and reduction of T-bet+, GATA-3+, and IL-17A+ expression in CD4+ cells when compared with the respective control groups. Resveratrol 0-11 interleukin 17A Mus musculus 137-143 27578011-10 2017 Moreover, resveratrol treatment resulted in upregulated expression of Foxp3 mRNA and decreased expression levels of T-bet, GATA-3, RORgammat, and IL-17A in the spleen and brain tissues. Resveratrol 10-21 T-box 21 Mus musculus 116-121 27578011-10 2017 Moreover, resveratrol treatment resulted in upregulated expression of Foxp3 mRNA and decreased expression levels of T-bet, GATA-3, RORgammat, and IL-17A in the spleen and brain tissues. Resveratrol 10-21 interleukin 17A Mus musculus 146-152 27578011-11 2017 Western blot analysis confirmed that resveratrol treatment decreased the protein expression of T-bet, GATA-3, RORgamma, and IL-17 and that it increased Foxp3 in B6 and BTBR mice. Resveratrol 37-48 T-box 21 Mus musculus 95-100 27578011-11 2017 Western blot analysis confirmed that resveratrol treatment decreased the protein expression of T-bet, GATA-3, RORgamma, and IL-17 and that it increased Foxp3 in B6 and BTBR mice. Resveratrol 37-48 interleukin 17A Mus musculus 124-129 28713934-10 2017 AMPK expression was increased, whereas mTOR expression was reduced in the resveratrol treatment groups. Resveratrol 74-85 mechanistic target of rapamycin kinase Rattus norvegicus 39-43 28827661-6 2017 Significantly, resveratrol activates SIRT7 deacetylase activity, inhibits breast cancer lung metastases, and increases survival. Resveratrol 15-26 sirtuin 7 Homo sapiens 37-42 28656303-10 2017 In conclusion, the present study demonstrated that resveratrol may be a potential therapeutic agent for the treatment of chronic stress-induced cognitive impairments, and its underlying molecular mechanism may be associated with the increased levels of hippocampal BDNF. Resveratrol 51-62 brain-derived neurotrophic factor Rattus norvegicus 265-269 28412652-0 2017 During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent. Resveratrol 33-44 sirtuin 1 Homo sapiens 96-100 28412652-1 2017 Resveratrol (RSV) is a naturally occurring polyphenolic compound endowed with interesting biological properties/functions amongst which are its activity as an antioxidant and as Sirtuin activating compound towards SIRT1 in mammals. Resveratrol 0-11 sirtuin 1 Homo sapiens 214-219 28412652-1 2017 Resveratrol (RSV) is a naturally occurring polyphenolic compound endowed with interesting biological properties/functions amongst which are its activity as an antioxidant and as Sirtuin activating compound towards SIRT1 in mammals. Resveratrol 13-16 sirtuin 1 Homo sapiens 214-219 28412652-4 2017 In the field of aging researches, it is well known that Sir2 is a positive regulator of replicative lifespan and, in this context, the RSV effects have been already examined. Resveratrol 135-138 sirtuin 1 Homo sapiens 56-60 28412652-5 2017 Here, we analyzed RSV effects during chronological aging, in which Sir2 acts as a negative regulator of chronological lifespan (CLS). Resveratrol 18-21 sirtuin 1 Homo sapiens 67-71 28744004-5 2017 Moreover, a Sirt1 activator resveratrol stimulated the inhibitory AMPK axis, with reciprocal suppression of the stimulatory PTP1B/Syk axis, thus potently inhibiting anaphylaxis. Resveratrol 28-39 sirtuin 1 Homo sapiens 12-17 28744004-5 2017 Moreover, a Sirt1 activator resveratrol stimulated the inhibitory AMPK axis, with reciprocal suppression of the stimulatory PTP1B/Syk axis, thus potently inhibiting anaphylaxis. Resveratrol 28-39 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 124-129 28744004-5 2017 Moreover, a Sirt1 activator resveratrol stimulated the inhibitory AMPK axis, with reciprocal suppression of the stimulatory PTP1B/Syk axis, thus potently inhibiting anaphylaxis. Resveratrol 28-39 spleen associated tyrosine kinase Homo sapiens 130-133 28819432-5 2017 Moreover, after treatment of the BCa cells using PPARgamma antagonist (GW9662) and SIRT1 agonist (resveratrol, RSV) respectively, thee phenotypes of cell cycle arrest, increased ROS production and inhibited proliferation rate were all rescued. Resveratrol 98-109 sirtuin 1 Homo sapiens 83-88 28669597-7 2017 Resveratrol treatment increased Unc-51-like kinase1, Beclin1, microtubule-associated protein light chain 3, hypoxia inducible factor-1alpha, phosphorylated AMPK, collagen-2A1, Aggrecan expressions, but decreased hypoxia inducible factor-2alpha, phosphorylated mTOR, matrix metalloproteinases13 and a disintegrin and metalloproteinase with thrombospondin motifs 5 expressions. Resveratrol 0-11 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Mus musculus 266-362 28150875-0 2017 ATP2A3 gene as an important player for resveratrol anticancer activity in breast cancer cells. Resveratrol 39-50 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 0-6 28150875-5 2017 In this work, we used breast cancer cell lines (MCF-7 and MDA-MB-231) to evaluate mRNA levels of ATP2A2 and ATP2A3 genes in response to RSV treatment. Resveratrol 136-139 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 108-114 28150875-6 2017 Our results demonstrate that RSV treatment induced the expression of ATP2A3 gene in both cell lines in a time and concentration-dependent manner, while the expression of ATP2A2 gene remained unaffected. Resveratrol 29-32 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 69-75 28150875-7 2017 The RSV-induced expression of SERCA3 in these breast cancer cell lines produced decreased cell viability, triggered apoptosis and changes in cytosolic Ca2+ levels, as well as changes in the capacity for Ca2+ release by the ER. Resveratrol 4-7 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 30-36 28150875-8 2017 These data suggest an important participation of SERCA3 genes in RSV-mediated anti-tumor effect in breast cancer cell lines. Resveratrol 65-68 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 49-55 28534975-0 2017 Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells. Resveratrol 0-11 bone morphogenetic protein 7 Homo sapiens 64-68 27792110-8 2017 Besides, when resveratrol activated Sirt1, nucleus pulposus cells proliferation increased while the cell apoptosis ratio decreased; the expression of type II collagen increased while MMP-13, ADAMTS-5 decreased. Resveratrol 14-25 sirtuin 1 Homo sapiens 36-41 27792110-8 2017 Besides, when resveratrol activated Sirt1, nucleus pulposus cells proliferation increased while the cell apoptosis ratio decreased; the expression of type II collagen increased while MMP-13, ADAMTS-5 decreased. Resveratrol 14-25 ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens 191-199 28666466-13 2017 RSV upregulated Sirt1 and its activity, and reduced the expression of leptin. Resveratrol 0-3 sirtuin 1 Homo sapiens 16-21 28666466-20 2017 CONCLUSION: These data indicate that RSV promotes Sirt1 levels, inhibits the endogenous expression of leptin by OA osteoblasts and can promote the Wnt/beta-catenin and Erk1/2 signaling pathways, which are altered in these cells. Resveratrol 37-40 sirtuin 1 Homo sapiens 50-55 28706491-8 2017 Morris water maze test, Western blotting, immunohistofluorescence staining and RT-qPCR indicated that resveratrol ameliorated spatial learning and memory deficits with alterations in hippocampal BDNF-TrkB signaling, promoted nuclear localization and phosphorylation of hippocampal SIRT1, partly increased protein levels of AMPK and PGC-1alpha involving in modulation of antioxidant response in Pb-exposed mice. Resveratrol 102-113 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 200-204 28578410-9 2017 Moreover, resveratrol suppressed the elevation of p66shc in the liver by reversing Con-A-mediated downregulation of SIRT1. Resveratrol 10-21 src homology 2 domain-containing transforming protein C1 Mus musculus 50-56 28578410-10 2017 The findings suggest that resveratrol protected against Con A-induced hepatitis in aged mice by attenuating an aberration of immune response and liver regeneration, partially via the mechanism of SIRT1-mediated repression of p66shc expression. Resveratrol 26-37 src homology 2 domain-containing transforming protein C1 Mus musculus 225-231 27058985-9 2017 Some of the gene-regulating effects of resveratrol are mediated by the histone/protein deacetylase sirtuin 1 or by the nuclear factor-E2-related factor-2. Resveratrol 39-50 sirtuin 1 Homo sapiens 99-108 28389348-5 2017 And the anti-inflammatory effect of resveratrol was measured by histopathological examination, MPO assay, real-time PCR and western blotting analysis. Resveratrol 36-47 myeloperoxidase Mus musculus 95-98 28580300-0 2017 Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes. Resveratrol 0-11 sirtuin 1 Homo sapiens 81-86 28580300-7 2017 RESULTS: Rsv dose dependently enhanced Sirt1 expression and reduced TG accumulation. Resveratrol 9-12 sirtuin 1 Homo sapiens 39-44 28580300-8 2017 Rsv-induced reduction of TG accumulation was abolished by inhibition of Sirt1 and PGC1alpha. Resveratrol 0-3 sirtuin 1 Homo sapiens 72-77 28286268-0 2017 Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1alpha and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells. Resveratrol 0-11 forkhead box O3 Mus musculus 134-140 28286268-6 2017 Meanwhile, resveratrol remarkably reduced mROS generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2. Resveratrol 11-22 forkhead box O3 Mus musculus 143-149 28286268-8 2017 Taken together, our data suggest a novel mechanism of action for resveratrol-attenuated Cd-induced cellular damage, which, in part, was mediated through the activation of the Sirt3/FoxO3a signaling pathway. Resveratrol 65-76 forkhead box O3 Mus musculus 181-187 28473882-7 2017 SIRT1 activator resveratrol significantly reduced the expression of MMP-13 and SIRT1 inhibitor EX-527 enhanced the expression of MMP-13. Resveratrol 16-27 sirtuin 1 Homo sapiens 0-5 28473882-7 2017 SIRT1 activator resveratrol significantly reduced the expression of MMP-13 and SIRT1 inhibitor EX-527 enhanced the expression of MMP-13. Resveratrol 16-27 sirtuin 1 Homo sapiens 79-84 28473882-8 2017 Moreover, SIRT1 activation with resveratrol inhibited acetylation of NF-kappaB p65 and NF-kappaB transcriptional activity, which were enhanced by P.e LPS. Resveratrol 32-43 sirtuin 1 Homo sapiens 10-15 28420192-6 2017 After administration of TXNIP inhibitor-resveratrol (60 mg/kg), TXNIP small interfering RNA (siRNA) and the PERK inhibitor GSK2656157, TXNIP expression was significantly reduced, accompanied by an attenuation of apoptosis and prognostic indicators, including SAH grade, neurological deficits, brain water content, and blood-brain barrier (BBB) permeability. Resveratrol 40-51 thioredoxin interacting protein Rattus norvegicus 24-29 28406974-0 2017 Resveratrol reduces the apoptosis induced by cigarette smoke extract by upregulating MFN2. Resveratrol 0-11 mitofusin 2 Homo sapiens 85-89 28406974-4 2017 RESULTS: A 24 h incubation in 3.5% CSE induced apoptosis in HBE cells, and pretreatment of HBE cells with RSV (20 muM) significantly suppressed the CSE-induced apoptosis, prevented the CSE-induced decrease in MFN2 levels, suppressed BAX translocation to the mitochondria, and prevented mitochondrial membrane potential loss and cytochrome C release. Resveratrol 106-109 mitofusin 2 Homo sapiens 209-213 28406974-5 2017 However, following the transfection of MFN2 siRNA, the anti-apoptotic effects of RSV were significantly attenuated. Resveratrol 81-84 mitofusin 2 Homo sapiens 39-43 28406974-6 2017 CONCLUSION: The results of the present study demonstrated that RSV may protect bronchial epithelial cells from CS-induced apoptosis in vitro by preventing mitochondrial dysfunction, and MFN2 may be associated with the anti-apoptotic functions of RSV in HBE cells. Resveratrol 246-249 mitofusin 2 Homo sapiens 186-190 28267984-0 2017 Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer"s disease. Resveratrol 11-22 monoamine oxidase B Homo sapiens 93-98 28024794-3 2017 The aim of the present study was to investigate the effects of resveratrol treatment on the expression of the genes involved in insulin signalling cascade, such as Forkhead box protein O1 (FoxO1), 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and mammalian target of rapamycin (mTOR). Resveratrol 63-74 3-phosphoinositide dependent protein kinase 1 Homo sapiens 197-242 28024794-3 2017 The aim of the present study was to investigate the effects of resveratrol treatment on the expression of the genes involved in insulin signalling cascade, such as Forkhead box protein O1 (FoxO1), 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and mammalian target of rapamycin (mTOR). Resveratrol 63-74 3-phosphoinositide dependent protein kinase 1 Homo sapiens 244-249 28024794-7 2017 RESULTS: Resveratrol increased the expression of PDPK1, mTOR and FoxO1. Resveratrol 9-20 3-phosphoinositide dependent protein kinase 1 Homo sapiens 49-54 27787915-4 2017 Among the several potential candidates responsible for the anti-invasive effect promoted by Resveratrol, here we focused our attention on ARH-I (DIRAS3), that encodes a Ras homolog GTPase of 26-kDa. Resveratrol 92-103 DIRAS family GTPase 3 Homo sapiens 138-143 27787915-4 2017 Among the several potential candidates responsible for the anti-invasive effect promoted by Resveratrol, here we focused our attention on ARH-I (DIRAS3), that encodes a Ras homolog GTPase of 26-kDa. Resveratrol 92-103 DIRAS family GTPase 3 Homo sapiens 145-151 27787915-7 2017 On opposite, Resveratrol could counteract the IL-6 induction of cell migration in ovarian cancer cells through induction of autophagy in the cells at the migration front, which was paralleled by up-regulation of ARH-I and down-regulation of STAT3 expression. Resveratrol 13-24 DIRAS family GTPase 3 Homo sapiens 212-217 27787915-8 2017 Spautin 1-mediated disruption of BECLIN 1-dependent autophagy abrogated the effects of Resveratrol, while promoting cell migration. Resveratrol 87-98 beclin 1 Homo sapiens 33-41 28108221-6 2017 In order to understand the interaction of Sirt1 and mTOR cascade activity with Resv-induced changes in the INS-1E cell line, we generated stable Sirt1-down-regulated INS-1E cells, and analysed Sirt1-dependent effects of Resv with respect to mTOR cascade activity. Resveratrol 79-83 mechanistic target of rapamycin kinase Rattus norvegicus 52-56 28202018-3 2017 RESULTS: We identified a resveratrol O-methyltransferase (ROMT) function from a multifunctional caffeic acid O-methyltransferase (COMT) originating from Arabidopsis, which catalyzes the transfer of a methyl group to resveratrol resulting in pterostilbene production. Resveratrol 25-36 O-methyltransferase 1 Arabidopsis thaliana 96-128 28202018-3 2017 RESULTS: We identified a resveratrol O-methyltransferase (ROMT) function from a multifunctional caffeic acid O-methyltransferase (COMT) originating from Arabidopsis, which catalyzes the transfer of a methyl group to resveratrol resulting in pterostilbene production. Resveratrol 25-36 O-methyltransferase 1 Arabidopsis thaliana 130-134 28202018-3 2017 RESULTS: We identified a resveratrol O-methyltransferase (ROMT) function from a multifunctional caffeic acid O-methyltransferase (COMT) originating from Arabidopsis, which catalyzes the transfer of a methyl group to resveratrol resulting in pterostilbene production. Resveratrol 216-227 O-methyltransferase 1 Arabidopsis thaliana 96-128 28202018-3 2017 RESULTS: We identified a resveratrol O-methyltransferase (ROMT) function from a multifunctional caffeic acid O-methyltransferase (COMT) originating from Arabidopsis, which catalyzes the transfer of a methyl group to resveratrol resulting in pterostilbene production. Resveratrol 216-227 O-methyltransferase 1 Arabidopsis thaliana 130-134 27798117-9 2017 The major molecular targets of the action of resveratrol are growth factors and their signaling pathways, phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways, transcription factors, and SIRT-1. Resveratrol 45-56 sirtuin 1 Homo sapiens 209-215 27998828-3 2017 Human granulocytes and monocytes were stimulated with phorbol myristate acetate (PMA) and the ability of resveratrol, hydroxytyrosol and oleuropein to inhibit the oxidative burst and CD11b expression was measured. Resveratrol 105-116 integrin subunit alpha M Homo sapiens 183-188 27998828-7 2017 All the tested compounds inhibited granulocytes oxidative burst in a concentration dependent manner and CD11b expression was also significantly counteracted by resveratrol and hydroxytyrosol. Resveratrol 160-171 integrin subunit alpha M Homo sapiens 104-109 28000862-7 2017 Activation of SIRT1 by resveratrol significantly reversed the effects of LPS on A549 cells. Resveratrol 23-34 sirtuin 1 Homo sapiens 14-19 28025035-8 2017 CONCLUSION: The major finding of the study is that resveratrol restored the core and associated symptoms of autistic phenotype by suppressing oxidative-nitrosative stress, mitochondrial dysfunction, TNF-alpha and MMP-9 expression in PPA induced ASD in rats. Resveratrol 51-62 matrix metallopeptidase 9 Rattus norvegicus 213-218 28000876-10 2017 As an miR-196b/miR-1290 inhibitor, resveratrol was further demonstrated to exert antitumor effects on ALL cells including antiproliferation, cell cycle arrest, apoptosis and inhibition of migration. Resveratrol 35-46 microRNA 1290 Homo sapiens 15-23 28000876-13 2017 Taken together, the present study provides evidence that resveratrol targets miR-196b and miR-1290 for its antitumor activity in T-ALL and B-ALL, respectively. Resveratrol 57-68 microRNA 1290 Homo sapiens 90-98 28957797-3 2017 Given that resveratrol activates sirtuin (Sirt)1, the present study examined whether this is mediated by Shh signaling. Resveratrol 11-22 sirtuin 1 Homo sapiens 42-48 28957797-10 2017 CONCLUSIONS: Resveratrol reduces neuronal injury following OGD/R injury and enhances neurite outgrowth and synaptogenesis by activating Shh signaling, which in turn induces Sirt1. Resveratrol 13-24 sirtuin 1 Homo sapiens 173-178 27705937-0 2016 Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway. Resveratrol 43-54 vascular endothelial growth factor B Homo sapiens 98-104 27705937-1 2016 Our previous study showed that resveratrol (RSV) exhibited not only anti-tumor effect, but also had potential tumor promotion effect on pancreatic cancer (Paca) cells through up-regulation of VEGF-B. Resveratrol 31-42 vascular endothelial growth factor B Homo sapiens 192-198 27705937-1 2016 Our previous study showed that resveratrol (RSV) exhibited not only anti-tumor effect, but also had potential tumor promotion effect on pancreatic cancer (Paca) cells through up-regulation of VEGF-B. Resveratrol 44-47 vascular endothelial growth factor B Homo sapiens 192-198 27705937-6 2016 Combination treatment significantly decreased VEGF-B expression and inhibited activity of GSK-3beta when compared to the RSV alone treatment. Resveratrol 121-124 vascular endothelial growth factor B Homo sapiens 46-52 27530621-8 2016 Using the activator of SIRT1, resveratrol, could promote the above-mentioned process of osteogenic differentiation. Resveratrol 30-41 sirtuin 1 Homo sapiens 23-28 27590234-5 2016 Compared with the LC-induced mouse, the level of inflammatory cytokines (IL-17, IL-6, TNF-alpha, and TGF-beta) of the BALF in the resveratrol + cigarette smoke-treated mouse had obviously decreased. Resveratrol 130-141 interleukin 17A Mus musculus 73-78 27878240-3 2016 In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)-tolerant THP-1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF-alpha. Resveratrol 157-168 sirtuin 1 Homo sapiens 140-145 27697644-6 2016 A subset of these compounds, such as curcumin and resveratrol, affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation. Resveratrol 50-61 DNA methyltransferase 1 Homo sapiens 111-115 27275930-7 2016 In platelets isolated from SIRT1-TG mice as well as in platelets treated with resveratrol or reSIRT1, PAFR expression was decreased, whereas this expressional downregulation by SIRT1 activators was inhibited in platelets treated with MG132 (a proteasome inhibitor) or NH4Cl (a lysosome inhibitor). Resveratrol 78-89 platelet-activating factor receptor Mus musculus 102-106 27901083-0 2016 Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation. Resveratrol 0-11 sirtuin 1 Homo sapiens 74-79 27901083-1 2016 Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD+-dependent deacetylases. Resveratrol 0-11 sirtuin 1 Homo sapiens 140-145 27901083-2 2016 SIRT1 has emerged as an attractive therapeutic target for many aging related diseases, however, how its activity can only be activated toward some specific substrates by resveratrol has been poorly understood. Resveratrol 170-181 sirtuin 1 Homo sapiens 0-5 27901083-3 2016 Herein, by employing extensive molecular dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we have clarified current controversies in the literature and elucidated that resveratrol plays an important activation role by stabilizing SIRT1/peptide interactions in a substrate-specific manner. Resveratrol 213-224 sirtuin 1 Homo sapiens 275-280 27901083-4 2016 This new mechanism highlights the importance of the N-terminal domain in substrate recognition, explains the activity restoration role of resveratrol toward some "loose-binding" substrates of SIRT1, and has significant implications for the rational design of new substrate-specific SIRT1 modulators. Resveratrol 138-149 sirtuin 1 Homo sapiens 192-197 27901083-4 2016 This new mechanism highlights the importance of the N-terminal domain in substrate recognition, explains the activity restoration role of resveratrol toward some "loose-binding" substrates of SIRT1, and has significant implications for the rational design of new substrate-specific SIRT1 modulators. Resveratrol 138-149 sirtuin 1 Homo sapiens 282-287 27276511-0 2016 Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice. Resveratrol 14-25 collapsin response mediator protein 1 Mus musculus 34-38 27276511-4 2016 RESULTS: Metformin and resveratrol inhibited ROS-associated mitochondrial fission by upregulating Drp1 phosphorylation (Ser 637) in an AMPK-dependent manner, and then suppressed ER stress indicated by dephosphorylation of IRE1alpha and eIF2alpha in the adipose tissue. Resveratrol 23-34 collapsin response mediator protein 1 Mus musculus 98-102 27276511-6 2016 CONCLUSION: Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult. Resveratrol 26-37 collapsin response mediator protein 1 Mus musculus 86-90 27716232-11 2016 Resveratrol inhibited the expression of PPAR-gamma and promoted FSP27 expression, thus fundamentally improving IR. Resveratrol 0-11 peroxisome proliferator-activated receptor gamma Rattus norvegicus 40-50 27716232-13 2016 Resveratrol can correct fat formation and storage imbalance status by up-regulating FSP27 and down-regulating PPAR-gamma expression level, ameliorating insulin sensitivity. Resveratrol 0-11 peroxisome proliferator-activated receptor gamma Rattus norvegicus 110-120 27591219-2 2016 This study examined whether resveratrol could protect against LPS-induced cardiac dysfunction by improving the sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA2a) activity. Resveratrol 28-39 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 159-166 27591219-9 2016 Resveratrol treatment upregulated SERCA2a, the oligomer form of PLB, and Nrf-2 expression and function, and downregulated MDA, 4-HNE, and the monomer form of PLB. Resveratrol 0-11 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 34-41 27591219-11 2016 Resveratrol protects the heart from LPS-induced injuries at least in part through promoting the oligomerization of PLB that leads to enhanced SERCA2a activity. Resveratrol 0-11 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 142-149 27332935-4 2016 RSV administration alleviated MI/R injury in diabetic mice, as evidenced by reduced infarct size, cardiomyocyte apoptosis, and caspase-3 activity, and improved cardiac function. Resveratrol 0-3 caspase 3 Mus musculus 127-136 26118420-2 2016 Resveratrol has previously shown to decrease DNA-methyltransferase (DNMT) enzymes expression and to reactivate silenced tumor suppressor genes. Resveratrol 0-11 DNA methyltransferase 1 Homo sapiens 45-66 26118420-2 2016 Resveratrol has previously shown to decrease DNA-methyltransferase (DNMT) enzymes expression and to reactivate silenced tumor suppressor genes. Resveratrol 0-11 DNA methyltransferase 1 Homo sapiens 68-72 26118420-4 2016 Recently, we reported the synthesis of resveratrol-salicylate derivatives and by examining the chemical structure of these analogs, we proposed that these compounds could exhibit DNMT inhibition especially that they resembled NSC 14778, a compound we previously identified as a DNMT inhibitor by virtual screening. Resveratrol 39-50 DNA methyltransferase 1 Homo sapiens 179-183 26118420-4 2016 Recently, we reported the synthesis of resveratrol-salicylate derivatives and by examining the chemical structure of these analogs, we proposed that these compounds could exhibit DNMT inhibition especially that they resembled NSC 14778, a compound we previously identified as a DNMT inhibitor by virtual screening. Resveratrol 39-50 DNA methyltransferase 1 Homo sapiens 278-282 26118420-5 2016 Indeed, using in vitro DNMT inhibition assay, some of the resveratrol-salicylate analogs we screened in this work that showed selective inhibition against DNMT3 enzymes which were greater than resveratrol. Resveratrol 58-69 DNA methyltransferase 1 Homo sapiens 23-27 27385446-0 2016 Resveratrol administration increases Transthyretin protein levels ameliorating AD features- importance of transthyretin tetrameric stability. Resveratrol 0-11 transthyretin Mus musculus 37-50 27385446-0 2016 Resveratrol administration increases Transthyretin protein levels ameliorating AD features- importance of transthyretin tetrameric stability. Resveratrol 0-11 transthyretin Mus musculus 106-119 27385446-1 2016 Previous in vivo work showed that resveratrol has beneficial effects in the AD pathology, resulting in increased expression of transthyretin (TTR). Resveratrol 34-45 transthyretin Mus musculus 127-140 27385446-1 2016 Previous in vivo work showed that resveratrol has beneficial effects in the AD pathology, resulting in increased expression of transthyretin (TTR). Resveratrol 34-45 transthyretin Mus musculus 142-145 27385446-3 2016 Further, resveratrol binds TTR, stabilizing the native TTR tetrameric structure. Resveratrol 9-20 transthyretin Mus musculus 27-30 27385446-3 2016 Further, resveratrol binds TTR, stabilizing the native TTR tetrameric structure. Resveratrol 9-20 transthyretin Mus musculus 55-58 27385446-7 2016 To further understand the mechanism(s) underlying such improvement in AD features, we measured TTR plasma levels showing that TTR increased in resveratrol-treated mice, whereas liver TTR gene transcription was not altered. Resveratrol 143-154 transthyretin Mus musculus 126-129 27385446-7 2016 To further understand the mechanism(s) underlying such improvement in AD features, we measured TTR plasma levels showing that TTR increased in resveratrol-treated mice, whereas liver TTR gene transcription was not altered. Resveratrol 143-154 transthyretin Mus musculus 126-129 27385446-9 2016 Therefore, resveratrol which stabilizes the TTR tetramer results in TTR normalized clearance, thus increasing the protein plasma levels. Resveratrol 11-22 transthyretin Mus musculus 44-47 27385446-9 2016 Therefore, resveratrol which stabilizes the TTR tetramer results in TTR normalized clearance, thus increasing the protein plasma levels. Resveratrol 11-22 transthyretin Mus musculus 68-71 27677845-5 2016 Here we show for the first time that resveratrol decreases expression of pro-inflammatory mediators in airway epithelial cells and in the lung of mice by enhancing NTHi-induced MyD88 short, a negative regulator of inflammation, via inhibition of ERK1/2 activation. Resveratrol 37-48 myeloid differentiation primary response gene 88 Mus musculus 177-182 27489133-7 2016 Furthermore, RSV pretreatment substantially upregulated the expression of the SIRT1 gene by 6.8 fold, reduced the acetylation level of the forkhead transcription factor FOXO3a, and decreased the expression ratio of Bax/Bcl-2. Resveratrol 13-16 sirtuin 1 Homo sapiens 78-83 27489133-8 2016 All these results demonstrated that RSV exhibited significant protective effects on ZEA-induced cell damage, and this effect may be attributed to the upregulation of SIRT1 and activation of FOXO3a-mediated pathways to enhance the resistance of cells to oxidative stress induced by ZEA exposure. Resveratrol 36-39 sirtuin 1 Homo sapiens 166-171 27611176-8 2016 Resveratrol could suppress oxidative stress in AA rats and increase mtROS production by reducing autophagy protein Beclin1, LC3A/B and oxidative stress protein MnSOD to promoted the apoptosis of FLSs. Resveratrol 0-11 superoxide dismutase 2 Rattus norvegicus 160-165 27343375-6 2016 Metformin and resveratrol inhibited lipolysis through prevention of PKA/HSL activation by decreasing the accumulation of cAMP via preserving PDE3B. Resveratrol 14-25 lipase, hormone sensitive Mus musculus 72-75 27343375-7 2016 Metformin and resveratrol reduced FFAs influx and DAG accumulation, and thus improved insulin signaling in the muscle by inhibiting PKCtheta translocation. Resveratrol 14-25 protein kinase C, theta Mus musculus 132-140 27278736-12 2016 High glucose-modulated expression of uPA, E-cadherin and Glut-1 were inhibited by resveratrol. Resveratrol 82-93 solute carrier family 2 member 1 Homo sapiens 57-63 27162022-0 2016 Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling. Resveratrol 0-11 activating transcription factor 2 Homo sapiens 109-113 27162022-7 2016 Resveratrol also down-regulated B(a)P-induced testicular iNOS production through suppressing the activation of p38 MAPK and ATF2, thus improved the oxidative status of the testis and prevented apoptosis. Resveratrol 0-11 activating transcription factor 2 Homo sapiens 124-128 27513408-0 2016 Effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 expression in the hypercholesterolemic condition: a preliminary study. Resveratrol 11-22 nitric oxide synthase, endothelial Oryctolagus cuniculus 56-60 27513408-1 2016 BACKGROUND/AIM: The aim of this study was to determine the effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 mRNA expression in the hypercholesterolemic condition. Resveratrol 70-81 nitric oxide synthase, endothelial Oryctolagus cuniculus 115-119 27513408-9 2016 Mean eNOS mRNA expression level in the resveratrol group was similar to that in the control group but significantly higher than that in the hypercholesterolemia group (P < 0.001). Resveratrol 39-50 nitric oxide synthase, endothelial Oryctolagus cuniculus 5-9 27513408-10 2016 CONCLUSION: This preliminary study demonstrates the beneficial effects of resveratrol on cavernosal eNOS expression. Resveratrol 74-85 nitric oxide synthase, endothelial Oryctolagus cuniculus 100-104 27286657-7 2016 Resveratrol increased the phosphorylation of AMPK and silent information regulator T1 (SIRT1), and decreased phosphorylation of downstream effectors class O forkhead box (FoxO)1 and FoxO3a via increasing AdipoR1 and AdipoR2 in the renal cortex. Resveratrol 0-11 forkhead box O3 Mus musculus 182-188 23000914-9 2012 Furthermore, resveratrol, a well-known activator of SIRT1, mimicked the action of PPARdelta on Ang II-induced premature senescence and ROS generation. Resveratrol 13-24 sirtuin 1 Homo sapiens 52-57 23000914-9 2012 Furthermore, resveratrol, a well-known activator of SIRT1, mimicked the action of PPARdelta on Ang II-induced premature senescence and ROS generation. Resveratrol 13-24 peroxisome proliferator activated receptor delta Homo sapiens 82-91 22467433-10 2012 Resveratrol exerted a biphasic effect on adherent cells by enriching the ASC and OPC populations and enhancing osteogenic differentiation. Resveratrol 0-11 PYD and CARD domain containing Rattus norvegicus 73-76 22898769-8 2012 Endoplasmic reticulum (ER) stress was increased in response to RSV, as indicated by increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) and increased expression of CCAAT/enhancer binding protein homologous protein (CHOP). Resveratrol 63-66 eukaryotic translation initiation factor 2A Homo sapiens 150-159 22884509-0 2012 Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+CD25+ regulatory T cells in FM3A tumor bearing mice. Resveratrol 0-11 CD4 antigen Mus musculus 72-75 23127402-0 2012 [Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1]. Resveratrol 1-12 sirtuin 1 Homo sapiens 114-119 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Resveratrol 106-117 beclin 1 Homo sapiens 288-296 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Resveratrol 106-117 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 310-317 22252971-6 2012 RSV significantly also enhances BMP7-promoted proteoglycan synthesis as assessed by (35) S-sulfate incorporation. Resveratrol 0-3 bone morphogenetic protein 7 Homo sapiens 32-36 22252971-7 2012 Protein-DNA interaction arrays suggest that RSV inhibits the activation of transcription factors involved in inflammation and cartilage catabolic signaling pathways, including direct downstream regulators of MAPK (e.g., AP-1, PEA3) and NFkappaB. Resveratrol 44-47 ETS variant transcription factor 4 Homo sapiens 226-230 22197621-0 2012 BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 cells. Resveratrol 121-132 BRCA1 DNA repair associated Homo sapiens 0-6 22197621-8 2012 Conversely, the phytoalexin resveratrol, selected as a prototype dietary AhR antagonist, antagonized at physiologically relevant doses (1 mumol/L) the TCDD-induced repression of BRCA-1 protein, BRCA-1 promoter methylation and the recruitment of the AhR, MBD2, H3K9me3 and DNMTs (1, 3a and 3b). Resveratrol 28-39 BRCA1 DNA repair associated Homo sapiens 178-184 22197621-8 2012 Conversely, the phytoalexin resveratrol, selected as a prototype dietary AhR antagonist, antagonized at physiologically relevant doses (1 mumol/L) the TCDD-induced repression of BRCA-1 protein, BRCA-1 promoter methylation and the recruitment of the AhR, MBD2, H3K9me3 and DNMTs (1, 3a and 3b). Resveratrol 28-39 BRCA1 DNA repair associated Homo sapiens 194-200 22945685-8 2012 In mature adipocytes, resveratrol increased ATGL, CPT-1, deacetylase sirtuin 1 (SIRT-1), and PGC1-alpha expression. Resveratrol 22-33 sirtuin 1 Homo sapiens 69-78 22945685-8 2012 In mature adipocytes, resveratrol increased ATGL, CPT-1, deacetylase sirtuin 1 (SIRT-1), and PGC1-alpha expression. Resveratrol 22-33 sirtuin 1 Homo sapiens 80-86 23084643-0 2012 Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet. Resveratrol 0-11 uncoupling protein 2 Rattus norvegicus 33-53 23084643-10 2012 Our data might indicate that an increased number of mitochondria and, particularly, an increase in hepatic uncoupling protein 2 expression are involved in normalizing the hepatic fat content due to resveratrol supplementation in rodents fed a high-fat diet. Resveratrol 198-209 uncoupling protein 2 Rattus norvegicus 107-127 22272775-4 2012 Herein, we show that resveratrol, a natural phytoalexin, induces premature senescence in human A431 SCC cells, and that resveratrol-induced premature senescence is associated with a blockade of autolysosome formation, as assessed by the absence of colocalization of LC3 and Lamp-2, markers for autophagosomes and lysosomes, respectively. Resveratrol 120-131 microtubule associated protein 1 light chain 3 alpha Homo sapiens 266-269 22272775-4 2012 Herein, we show that resveratrol, a natural phytoalexin, induces premature senescence in human A431 SCC cells, and that resveratrol-induced premature senescence is associated with a blockade of autolysosome formation, as assessed by the absence of colocalization of LC3 and Lamp-2, markers for autophagosomes and lysosomes, respectively. Resveratrol 120-131 lysosomal associated membrane protein 2 Homo sapiens 274-280 22706671-0 2012 Resveratrol-poor red wines modulate SIRT1 in human renal cells. Resveratrol 0-11 sirtuin 1 Homo sapiens 36-41 22706671-2 2012 One of the most interesting biological properties of RSV and other naturally occurring phenols is the regulation of the expression and activity of SIRT1 (silent mating type information regulation 2 homolog). Resveratrol 53-56 sirtuin 1 Homo sapiens 147-152 22706671-3 2012 In view of the role of SIRT1 in acute and chronic renal diseases, we decided to study the effects of RSV-poor red wines on the expression of SIRT1 and HIF-2alpha (hypoxia-inducible factor 2alpha) to be compared with a nanomolar concentration of RSV or malvidin in proximal tubular cells of human kidneys (PTEC). Resveratrol 101-104 sirtuin 1 Homo sapiens 141-146 22706671-5 2012 PTEC cells were incubated in the presence of RSV-poor wines diluted 1:1,000 for 30", 90", 120" and 24 h. Expression of SIRT1 and HIF-2alpha, and activation of ERK and AMPK were analyzed by Western Blot. Resveratrol 45-48 sirtuin 1 Homo sapiens 119-124 22980652-9 2012 Western blotting showed that resveratrol reduced the expressions of perilipin, adipophilin and TIP-47 in the primary hepatocytes, especially the perilipin. Resveratrol 29-40 perilipin 2 Mus musculus 79-90 22692956-5 2012 Additionally, the repressive effect of resveratrol on in vitro malignant properties including invasiveness/anchorage-independent growth was mediated by regulating productions of EMT markers Slug, ZEB1, N-cadherin, E-cadherin, and Vimentin. Resveratrol 39-50 cadherin 2 Mus musculus 202-212 22692956-5 2012 Additionally, the repressive effect of resveratrol on in vitro malignant properties including invasiveness/anchorage-independent growth was mediated by regulating productions of EMT markers Slug, ZEB1, N-cadherin, E-cadherin, and Vimentin. Resveratrol 39-50 vimentin Mus musculus 230-238 22943042-25 2012 Results indicated some genes had large differences in the EGCG (e.g., Hsd3b and Sts) and the resveratrol (e.g., Hsd3b and Hrmt12) groups. Resveratrol 93-104 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 112-117 22689577-7 2012 In contrast, Sirt-1 activator resveratrol inhibited interleukin-1beta (IL-1beta)- and nicotinamide-induced NF-kappaB activation and p65 acetylation and suppressed the activation of IkappaB-alpha kinase. Resveratrol 30-41 sirtuin 1 Homo sapiens 13-19 22689577-8 2012 Resveratrol also reversed the IL-1beta- or nicotinamide-induced up-regulation of various gene products that mediate inflammation (cyclooxygenase-2) and matrix degradation (matrix metalloproteinase-9) that are known to be regulated by NF-kappaB. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 172-198 22689577-9 2012 Knockdown of Sirt-1 by using ASO abolished the inhibitory effects of resveratrol on inflammatory and apoptotic signaling including Akt activation and SCAX suppression. Resveratrol 69-80 sirtuin 1 Homo sapiens 13-19 22689577-10 2012 Down-regulation of histone deacetylase Sirt-1 by mRNA interference abrogated the effect of resveratrol on NF-kappaB suppression, thus highlighting the crucial homeostatic role of this enzyme. Resveratrol 91-102 sirtuin 1 Homo sapiens 39-45 22689577-11 2012 Overall, these results suggest for the first time that Sirt-1 can regulate p53 and NF-kappaB signaling via deacetylation, demonstrating a novel role for resveratrol in the treatment of tendinitis/tendinopathy. Resveratrol 153-164 sirtuin 1 Homo sapiens 55-61 22397755-10 2012 Resveratrol, a known Bcr-Abl inhibitor, reduced Gli-1 activation and inhibited the viability of CML cells. Resveratrol 0-11 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 21-28 22397755-10 2012 Resveratrol, a known Bcr-Abl inhibitor, reduced Gli-1 activation and inhibited the viability of CML cells. Resveratrol 0-11 GLI family zinc finger 1 Homo sapiens 48-53 22397755-12 2012 Novel compounds inhibiting both Shh signaling and Bcr-Abl expression, such as resveratrol, may have potential to be effective agents against CML independent of IM resistance. Resveratrol 78-89 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 50-57 22288422-11 2012 Furthermore, resveratrol inhibited the H(2)O(2)-induced translocation of PKC-alpha from the cytosol to the cell membrane; this translocation is believed to activate NHE. Resveratrol 13-24 protein kinase C, alpha Rattus norvegicus 73-82 22104698-11 2012 The growth-inhibitory effect of resveratrol was accompanied by decreased expression of cyclin D3 and pRb. Resveratrol 32-43 RB transcriptional corepressor 1 Rattus norvegicus 101-104 22385246-5 2012 The SIRT1 inducers resveratrol and isonicotinamide attenuated MS-induced cytokine and chemokine expression, but enhanced the expression of defensins and TLRs. Resveratrol 19-30 sirtuin 1 Homo sapiens 4-9 22475539-4 2012 AREAS COVERED: Areas covered in this paper include a review of the patent literature associated with SIRT1 activators, with a focus on therapeutic applications, primarily related to the use of pharmaceuticals and nutraceuticals containing resveratrol (RSV), and the development of second-generation activators unrelated to RSV. Resveratrol 239-250 sirtuin 1 Homo sapiens 101-106 22475539-4 2012 AREAS COVERED: Areas covered in this paper include a review of the patent literature associated with SIRT1 activators, with a focus on therapeutic applications, primarily related to the use of pharmaceuticals and nutraceuticals containing resveratrol (RSV), and the development of second-generation activators unrelated to RSV. Resveratrol 252-255 sirtuin 1 Homo sapiens 101-106 22475539-4 2012 AREAS COVERED: Areas covered in this paper include a review of the patent literature associated with SIRT1 activators, with a focus on therapeutic applications, primarily related to the use of pharmaceuticals and nutraceuticals containing resveratrol (RSV), and the development of second-generation activators unrelated to RSV. Resveratrol 323-326 sirtuin 1 Homo sapiens 101-106 23554738-0 2012 Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Resveratrol 0-11 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 80-99 23554738-1 2012 Our previous studies showed that resveratrol could inhibit the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2). Resveratrol 33-44 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 160-179 23554738-1 2012 Our previous studies showed that resveratrol could inhibit the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2). Resveratrol 33-44 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 181-185 21706162-3 2012 In this study, we analyzed the effect of resveratrol on the gene expression levels of SIRT1, SIRT3, SIRT4, PGC1alpha, and NAMPT, as well as its effect on NAD(+) and NADH levels, in the liver of non stressed or non impaired wild-type zebrafish. Resveratrol 41-52 sirtuin 1 Danio rerio 86-91 22876687-8 2012 20-80 micromol/L resveratrol also induced apoptosis and apoptotic morphology change in Hepa 1-6 cells accompanied with caspase-3 activation and ROS generation. Resveratrol 17-28 caspase 3 Mus musculus 119-128 22876687-9 2012 CONCLUSION: Resveratrol could inhibit cell proliferation, induce apoptosis in murine hepatocarcinoma Hepa 1-6 cells, and the mechanism may associated with caspase-3 activation and ROS production. Resveratrol 12-23 caspase 3 Mus musculus 155-164 22304906-4 2012 now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1alpha. Resveratrol 14-25 sirtuin 1 Homo sapiens 183-188 21852339-2 2012 Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT)1 activity. Resveratrol 0-11 sirtuin 1 Homo sapiens 144-150 22056336-5 2012 Resveratrol significantly inhibited ethanol metabolism by regulating alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) mRNA expressions. Resveratrol 0-11 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 69-93 22056336-5 2012 Resveratrol significantly inhibited ethanol metabolism by regulating alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) mRNA expressions. Resveratrol 0-11 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 95-100 22037246-5 2012 At the same time, resveratrol treatment slowed the cell cycle in the S phase without inducing apoptosis, and increased Sirt1 expression, also affecting its intracellular localisation. Resveratrol 18-29 sirtuin 1 Homo sapiens 119-124 22037246-6 2012 CONCLUSIONS: Our results show that the metabolomic analysis of the exometabolome of resveratrol-treated HepG2 cells indicates a metabolic switch from glucose and amino acid utilisation to fat utilisation for the production of energy, and seem in agreement with an effect mediated via AMPK- and Sirt1-activation. Resveratrol 84-95 sirtuin 1 Homo sapiens 294-299 22382311-2 2012 Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Resveratrol 14-25 sirtuin 1 Homo sapiens 275-280 23251493-6 2012 This occurs as a consequence of the inhibition of EBV-induced NFkappaB and STAT-3 signaling pathways and a resveratrol-induced decrease in the expression of the oncogenic viral product LMP1 in EBV-infected B cells. Resveratrol 107-118 PDZ and LIM domain 7 Homo sapiens 185-189 23251493-7 2012 In addition, resveratrol decreased the expression of miR-155 and miR-34a in EBV-infected B cells, blocked the expression of the anti-apoptotic viral gene BHRF1, and thus interrupted events that are critical for EBV transformation and the survival of EBV-transformed cells. Resveratrol 13-24 microRNA 155 Homo sapiens 53-60 22815866-11 2012 Serial (99m)Tc-Annexin V imaging showed clear increases in pulmonary and cardiac apoptosis when compared to baseline, which regressed following resveratrol treatment. Resveratrol 144-155 annexin A5 Rattus norvegicus 15-24 22363816-11 2012 In addition, mTOR inhibition partially abolished the inhibitory effect of resveratrol on the phosphorylation of IkappaB-alpha, CREB, extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal protein kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK). Resveratrol 74-85 mitogen-activated protein kinase 8 Mus musculus 185-216 22363816-11 2012 In addition, mTOR inhibition partially abolished the inhibitory effect of resveratrol on the phosphorylation of IkappaB-alpha, CREB, extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal protein kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK). Resveratrol 74-85 mitogen-activated protein kinase 8 Mus musculus 218-221 20697895-0 2012 Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner. Resveratrol 0-11 sirtuin 1 Homo sapiens 82-91 20697895-5 2012 Resveratrol upregulated the expression of the NAD-dependent deacetylase sirtuin 1 mRNA and downregulated the expression of the Bcl-X(L) mRNA, and resveratrol-induced MH7A cell death, mitochondrial damage, and caspase-3/-9 activation were prevented by sirtinol, an inhibitor of sirtuin 1. Resveratrol 0-11 sirtuin 1 Homo sapiens 72-81 20697895-5 2012 Resveratrol upregulated the expression of the NAD-dependent deacetylase sirtuin 1 mRNA and downregulated the expression of the Bcl-X(L) mRNA, and resveratrol-induced MH7A cell death, mitochondrial damage, and caspase-3/-9 activation were prevented by sirtinol, an inhibitor of sirtuin 1. Resveratrol 0-11 sirtuin 1 Homo sapiens 277-286 20697895-6 2012 The results of the present study show that resveratrol induces MH7A cell apoptosis by activating caspase-9 and the effector caspase-3 along mitochondrial disruption as a result of reduced Bcl-X(L) expression, allowing cytochrome c release from the mitochondria into the cytosol, in a sirtuin 1-dependent manner. Resveratrol 43-54 sirtuin 1 Homo sapiens 284-293 22146233-0 2012 Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Resveratrol 0-11 F-box protein 32 Homo sapiens 108-117 22146233-2 2012 Resveratrol, a sirtuin-1 (SIRT1) pathway activator, can prevent the development of PH in a commonly used animal model, but it is unclear whether it can reverse established PH pathophysiology. Resveratrol 0-11 sirtuin 1 Homo sapiens 15-24 22146233-2 2012 Resveratrol, a sirtuin-1 (SIRT1) pathway activator, can prevent the development of PH in a commonly used animal model, but it is unclear whether it can reverse established PH pathophysiology. Resveratrol 0-11 sirtuin 1 Homo sapiens 26-31 22146233-4 2012 Therefore, we hypothesized that monocrotaline (MCT)-induced PH would attenuate atrophy pathways in the PA while, conversely, SIRT1 activation (resveratrol) would reverse indices of PH and restore atrophic gene expression. Resveratrol 143-154 sirtuin 1 Homo sapiens 125-130 22146233-8 2012 Resveratrol also normalized PA atrogin-1 mRNA expression, which was significantly reduced by MCT. Resveratrol 0-11 F-box protein 32 Homo sapiens 31-40 22146233-9 2012 In cultured human PA smooth muscle cells (hPASMC), resveratrol significantly inhibited PDGF-stimulated proliferation and cellular hypertrophy, which was also associated with improvements in atrogin-1 levels. Resveratrol 51-62 F-box protein 32 Homo sapiens 190-199 22058332-9 2011 Administration of resveratrol to diabetic mice significantly reduced diabetes-induced retinal leukocyte adhesion, together with retinal expression of ICAM-1 and VEGF. Resveratrol 18-29 vascular endothelial growth factor A Mus musculus 161-165 21942447-6 2011 Pretreatment of resveratrol, but not pterostlbene, suppressed EGF-mediated migration and expression of MED28 and matrix metalloproteinase (MMP)-9 in MDA-MB-231 cells. Resveratrol 16-27 matrix metallopeptidase 9 Homo sapiens 113-145 22055504-4 2011 In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Resveratrol 11-22 sirtuin 1 Homo sapiens 49-54 21188630-0 2011 Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Resveratrol 0-11 fatty acid synthase Homo sapiens 70-89 21188630-5 2011 This inhibitory effect of resveratrol is accompanied by a significant reduction in lipid synthesis which is caused by the down-regulation of the fatty acid synthase (FAS) gene followed by up-regulation of pro-apoptotic genes, DAPK2 and BNIP3. Resveratrol 26-37 fatty acid synthase Homo sapiens 145-164 21188630-5 2011 This inhibitory effect of resveratrol is accompanied by a significant reduction in lipid synthesis which is caused by the down-regulation of the fatty acid synthase (FAS) gene followed by up-regulation of pro-apoptotic genes, DAPK2 and BNIP3. Resveratrol 26-37 fatty acid synthase Homo sapiens 166-169 21188630-6 2011 The activation of apoptotic pathway in the cancer stem-like cells was suppressed by TOFA and by Fumonisin B1, suggesting that resveratrol-induced apoptosis is indeed through the modulation of FAS-mediated cell survival signaling. Resveratrol 126-137 fatty acid synthase Homo sapiens 192-195 21188630-8 2011 Taken together, the results of this study indicate that resveratrol is capable of inducing apoptosis in the cancer stem-like cells through suppression of lipogenesis by modulating FAS expression, which highlights a novel mechanism of anti-tumor effect of resveratrol. Resveratrol 56-67 fatty acid synthase Homo sapiens 180-183 21188630-8 2011 Taken together, the results of this study indicate that resveratrol is capable of inducing apoptosis in the cancer stem-like cells through suppression of lipogenesis by modulating FAS expression, which highlights a novel mechanism of anti-tumor effect of resveratrol. Resveratrol 255-266 fatty acid synthase Homo sapiens 180-183 20730501-6 2011 RSV also enhanced the CD4+CD25+ population in old mice. Resveratrol 0-3 CD4 antigen Mus musculus 22-25 20730501-6 2011 RSV also enhanced the CD4+CD25+ population in old mice. Resveratrol 0-3 interleukin 2 receptor, alpha chain Mus musculus 26-30 21719763-9 2011 Activation of SIRT1 by resveratrol significantly reduced the senescence-associated calcification. Resveratrol 23-34 sirtuin 1 Homo sapiens 14-19 21620820-7 2011 Changes induced by trans resveratrol could be correlated well with alterations in the expression of Bax, Bcl(2), Caspase-3 and HIF-1alpha. Resveratrol 25-36 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 127-137 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Resveratrol 184-187 glutathione peroxidase 1 Homo sapiens 45-50 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Resveratrol 184-187 sirtuin 1 Homo sapiens 112-121 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Resveratrol 184-187 sirtuin 1 Homo sapiens 123-128 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Resveratrol 184-187 glutathione peroxidase 1 Homo sapiens 229-234 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Resveratrol 184-187 sirtuin 1 Homo sapiens 239-244 21892612-10 2011 In conclusion, RSV, probably by activating SIRT1 signaling pathway, inhibits the oxidative-stress-dependent phenotypical shift of ECs induced by HSS and proinflammatory factors in vitro. Resveratrol 15-18 sirtuin 1 Homo sapiens 43-48 21109418-0 2011 Resveratrol enhances fatty acid oxidation capacity and reduces resistin and Retinol-Binding Protein 4 expression in white adipocytes. Resveratrol 0-11 retinol binding protein 4, plasma Mus musculus 76-101 21109418-2 2011 Here, we sought to get further insight into the impact of resveratrol on adipocyte biology by studying its effects on oxidative metabolism and the expression of the insulin resistance-related adipokines resistin and Retinol-Binding Protein 4 (RBP4) in mature adipocytes. Resveratrol 58-69 retinol binding protein 4, plasma Mus musculus 216-241 21652783-2 2011 We previously showed that resveratrol (3,5,4"-trihydroxy-trans-stilbene), an antioxidant and activator of the NAD(+)-dependent protein deacetylase SIRT1, delays the progression of heart failure and prolongs the lifespan of delta-sarcoglycan-deficient hamsters. Resveratrol 26-37 sarcoglycan, delta (dystrophin-associated glycoprotein) Mus musculus 223-240 21652783-3 2011 Because a defect of dystroglycan complex causes muscular dystrophies, and delta-sarcoglycan is a component of this complex, we hypothesized that resveratrol might be a new therapeutic tool for muscular dystrophies. Resveratrol 145-156 sarcoglycan, delta (dystrophin-associated glycoprotein) Mus musculus 74-91 21652783-6 2011 In the muscles of these mice, resveratrol significantly decreased oxidative damage shown by the immunostaining of nitrotyrosine and 8-hydroxy-2"-deoxyguanosine and suppressed the up-regulation of NADPH oxidase subunits Nox4, Duox1, and p47(phox). Resveratrol 30-41 dual oxidase 1 Mus musculus 225-230 21689630-0 2011 Resveratrol inhibits genistein-induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells. Resveratrol 0-11 ATP binding cassette subfamily C member 2 Homo sapiens 72-76 21689630-2 2011 In this study, the effects of genistein and resveratrol on the multidrug resistance protein 2 (MRP2) expression and the underlying molecular mechanisms were investigated using HepG2-C3 cells that are stably transfected with a construct containing human MRP2 promoter region conjugated with luciferase reporter gene. Resveratrol 44-55 ATP binding cassette subfamily C member 2 Homo sapiens 63-93 21689630-2 2011 In this study, the effects of genistein and resveratrol on the multidrug resistance protein 2 (MRP2) expression and the underlying molecular mechanisms were investigated using HepG2-C3 cells that are stably transfected with a construct containing human MRP2 promoter region conjugated with luciferase reporter gene. Resveratrol 44-55 ATP binding cassette subfamily C member 2 Homo sapiens 95-99 21689630-3 2011 A 3-fold induction of MRP2 luciferase activity was observed after genistein (50muM) treatment to HepG2-C3 cells, but was diminished by the resveratrol (50muM) cotreatment. Resveratrol 139-150 ATP binding cassette subfamily C member 2 Homo sapiens 22-26 21689630-4 2011 This observation was further validated by Western blot analysis and RT-PCR analysis as resveratrol also inhibited genistein-induced MRP2 protein synthesis and mRNA expression. Resveratrol 87-98 ATP binding cassette subfamily C member 2 Homo sapiens 132-136 21689630-5 2011 Immunofluorescence study revealed that genistein-induced formation of MRP2 vacuoles was dramatically reduced by resveratrol. Resveratrol 112-123 ATP binding cassette subfamily C member 2 Homo sapiens 70-74 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 24-35 retinoid X receptor alpha Homo sapiens 79-87 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 24-35 ATP binding cassette subfamily C member 2 Homo sapiens 116-120 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 24-35 ATP binding cassette subfamily C member 2 Homo sapiens 214-218 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 233-244 retinoid X receptor alpha Homo sapiens 79-87 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 233-244 ATP binding cassette subfamily C member 2 Homo sapiens 116-120 21689630-7 2011 The results showed that resveratrol inhibited the genistein-induced binding of RXRalpha to the promoter sequence of MRP2 gene, and this mechanism could potentially contribute to the inhibition of genistein-induced MRP2 expression by resveratrol. Resveratrol 233-244 ATP binding cassette subfamily C member 2 Homo sapiens 214-218 21705453-2 2011 EXPERIMENTAL DESIGN: Resveratrol efficacy was evaluated against the HNSCC cells FaDu, Cal27, Det562, and Cal27-Smad4 for viability, DNA damage, cell-cycle progression, and apoptosis, as well as gamma-H2AX expression, and focus formation (gamma-H2AX and Brca1). Resveratrol 21-32 BRCA1 DNA repair associated Homo sapiens 253-258 21705453-7 2011 Furthermore, resveratrol caused S-phase arrest and apoptotic death of FaDu and Cal27 cells together with induction of Brca1 and gamma-H2AX foci. Resveratrol 13-24 BRCA1 DNA repair associated Homo sapiens 118-123 21705453-8 2011 Resveratrol (50 mg/kg body weight) treatment also inhibited FaDu tumor growth in nude mice, and gamma-H2AX and cleaved caspase-3 were strongly increased in xenografts from resveratrol-treated mice compared with controls. Resveratrol 172-183 caspase 3 Mus musculus 119-128 21530968-9 2011 The increased mRNA expression of monocyte chemotactic protein-1, tumor necrosis factor-alpha, intercellular adhesion molecule-1, CD68, vascular endothelial growth factor-A, p47, glutathione peroxidase (GPX)1 and GPX3 were attenuated by resveratrol treatment (all p<0.05). Resveratrol 236-247 chemokine (C-C motif) ligand 2 Mus musculus 33-92 21447053-10 2011 In contrast, resveratrol almost completely reduced the release of all cytokines and MMP-9 without significant differences between the cohorts. Resveratrol 13-24 matrix metallopeptidase 9 Homo sapiens 84-89 21467134-6 2011 Interestingly, extracellular signal-regulated kinases (ERK), c-Jun NH(2)-terminal kinases (JNK), and Akt also accumulate in lipid rafts on resveratrol exposure (IC(50) at 48 h 30 mumol/L in SW480 and U937 cells). Resveratrol 139-150 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 61-66 21467134-7 2011 In these rafts also, resveratrol promotes the recruitment, by the integrin alpha(V)beta(3) (revealed by coimmunoprecipitation with an anti-integrin alpha(V)beta(3) antibody), of signaling molecules that include the FAK (focal adhesion kinase), Fyn, Grb2, Ras, and SOS proteins. Resveratrol 21-32 integrin subunit alpha V Homo sapiens 66-90 21467134-7 2011 In these rafts also, resveratrol promotes the recruitment, by the integrin alpha(V)beta(3) (revealed by coimmunoprecipitation with an anti-integrin alpha(V)beta(3) antibody), of signaling molecules that include the FAK (focal adhesion kinase), Fyn, Grb2, Ras, and SOS proteins. Resveratrol 21-32 integrin subunit alpha V Homo sapiens 139-163 21966552-0 2011 Resveratrol inhibits mTOR signaling by targeting DEPTOR. Resveratrol 0-11 DEP domain containing MTOR interacting protein Homo sapiens 49-55 21966552-3 2011 The underlying mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1- and AMPK-independent mechanism. Resveratrol 112-115 sirtuin 1 Homo sapiens 189-194 21453744-5 2011 Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol. Resveratrol 176-187 solute carrier family 25 member 5 Homo sapiens 56-59 21306906-3 2011 In particular, much attention has been raised by neuroprotective effects attributed to SIRT1 activation due to genetically induced sirtuin overexpression or administration of resveratrol, a natural compound found in the skin of red grapes and also in wine. Resveratrol 175-186 sirtuin 1 Homo sapiens 87-92 21277758-0 2011 GADD45alpha and annexin A1 are involved in the apoptosis of HL-60 induced by resveratrol. Resveratrol 77-88 annexin A1 Homo sapiens 16-26 21277758-4 2011 Resveratrol treatment resulted in a gradual time-dependent decrease in the expression of anti-apoptotic Bcl-2 and increase in that of Bax, annexin A1, growth arrest- and DNA damage-induced gene 45alpha (GADD45alpha), and cleaved caspase-3. Resveratrol 0-11 annexin A1 Homo sapiens 139-149 21277758-6 2011 Our results suggest that resveratrol could inhibit the proliferation and induce apoptosis of HL-60 cells through a GADD45alpha and annexin A1/caspase-3 pathway. Resveratrol 25-36 annexin A1 Homo sapiens 131-141 21466813-0 2011 Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Resveratrol 0-11 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 103-109 21466813-12 2011 Resveratrol at its IC(50) mediated a four-fold induction of UGT1A1 mRNA in a concentration independent manner. Resveratrol 0-11 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 60-66 21439945-4 2011 In comparison with HFD-fed mice, mice fed with a 0.4% resveratrol-supplemented diet (RSD) showed significantly lower body weight gain (-48%), visceral fat-pad weights (-58%), and plasma levels of triglyceride, FFA, total cholesterol, glucose, tumor necrosis factor (TNF) alpha, and monocyte chemoattractant protein-1 (MCP1). Resveratrol 54-65 chemokine (C-C motif) ligand 2 Mus musculus 282-316 21439945-4 2011 In comparison with HFD-fed mice, mice fed with a 0.4% resveratrol-supplemented diet (RSD) showed significantly lower body weight gain (-48%), visceral fat-pad weights (-58%), and plasma levels of triglyceride, FFA, total cholesterol, glucose, tumor necrosis factor (TNF) alpha, and monocyte chemoattractant protein-1 (MCP1). Resveratrol 54-65 chemokine (C-C motif) ligand 2 Mus musculus 318-322 21439945-5 2011 Resveratrol significantly reversed the HFD-induced up-regulation of galanin-mediated signaling molecules (GalR1/2, PKCdelta, Cyc-D, E2F1, and p-ERK) and key adipogenic genes (PPARgamma2, C/EBPalpha, SREBP-1c, FAS, LPL, aP2, and leptin) in the epididymal adipose tissues of mice. Resveratrol 0-11 protein kinase C, delta Mus musculus 115-123 21439945-5 2011 Resveratrol significantly reversed the HFD-induced up-regulation of galanin-mediated signaling molecules (GalR1/2, PKCdelta, Cyc-D, E2F1, and p-ERK) and key adipogenic genes (PPARgamma2, C/EBPalpha, SREBP-1c, FAS, LPL, aP2, and leptin) in the epididymal adipose tissues of mice. Resveratrol 0-11 lipoprotein lipase Mus musculus 214-217 21439945-6 2011 Furthermore, resveratrol significantly attenuated the HFD-induced up-regulation of pro-inflammatory cytokines (TNFalpha, IFNalpha, IFNbeta, and IL-6) and their upstream signaling molecules (TLR2/4, MyD88, Tirap, TRIF, TRAF6, IRF5, p-IRF3, and NF-kappaB) in the adipose tissues of mice. Resveratrol 13-24 interferon alpha Mus musculus 121-129 21439945-6 2011 Furthermore, resveratrol significantly attenuated the HFD-induced up-regulation of pro-inflammatory cytokines (TNFalpha, IFNalpha, IFNbeta, and IL-6) and their upstream signaling molecules (TLR2/4, MyD88, Tirap, TRIF, TRAF6, IRF5, p-IRF3, and NF-kappaB) in the adipose tissues of mice. Resveratrol 13-24 interferon beta 1, fibroblast Mus musculus 131-138 21439945-6 2011 Furthermore, resveratrol significantly attenuated the HFD-induced up-regulation of pro-inflammatory cytokines (TNFalpha, IFNalpha, IFNbeta, and IL-6) and their upstream signaling molecules (TLR2/4, MyD88, Tirap, TRIF, TRAF6, IRF5, p-IRF3, and NF-kappaB) in the adipose tissues of mice. Resveratrol 13-24 myeloid differentiation primary response gene 88 Mus musculus 198-203 21439945-6 2011 Furthermore, resveratrol significantly attenuated the HFD-induced up-regulation of pro-inflammatory cytokines (TNFalpha, IFNalpha, IFNbeta, and IL-6) and their upstream signaling molecules (TLR2/4, MyD88, Tirap, TRIF, TRAF6, IRF5, p-IRF3, and NF-kappaB) in the adipose tissues of mice. Resveratrol 13-24 toll-like receptor adaptor molecule 2 Mus musculus 212-216 21460620-3 2011 The deacetylase sirtuin 1 (SIRT1) and its orthologs are required for the autophagy induction by resveratrol but dispensable for autophagy stimulation by spermidine in human cells, Saccharomyces cerevisiae and C. elegans. Resveratrol 96-107 sirtuin 1 Homo sapiens 16-25 21460620-3 2011 The deacetylase sirtuin 1 (SIRT1) and its orthologs are required for the autophagy induction by resveratrol but dispensable for autophagy stimulation by spermidine in human cells, Saccharomyces cerevisiae and C. elegans. Resveratrol 96-107 sirtuin 1 Homo sapiens 27-32 21332948-2 2011 Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively. Resveratrol 0-11 carbonic anhydrase 1 Homo sapiens 110-115 21332948-2 2011 Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively. Resveratrol 0-11 carbonic anhydrase 2 Homo sapiens 145-151 21419119-0 2011 Extracellular HIV-1 Tat upregulates TNF-alpha dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: inhibition by resveratrol, a polyphenolic phytostilbene. Resveratrol 160-171 Tat Human immunodeficiency virus 1 20-23 21480283-8 2011 RESULTS: Resveratrol(100 muM) significantly increased CFTR-mediated Cl- transport (change in short-circuit current, DeltaI(SC) ) in both MNSE (13.51 +- 0.77 vs. 4.4 +- 0.66 [control]; P < .05) and HSNE (12.28 +- 1.08 vs. 0.69 +- 0.32 [control]; P < .05). Resveratrol 9-20 cystic fibrosis transmembrane conductance regulator Mus musculus 54-58 21595514-8 2011 In addition, resveratrol"s ability to activate the sirtuin1 (SIRT1) pathway has been heavily implicated in the mechanisms controlling longevity and quality of life in the aged population. Resveratrol 13-24 sirtuin 1 Homo sapiens 51-59 21595514-8 2011 In addition, resveratrol"s ability to activate the sirtuin1 (SIRT1) pathway has been heavily implicated in the mechanisms controlling longevity and quality of life in the aged population. Resveratrol 13-24 sirtuin 1 Homo sapiens 61-66 21932511-3 2011 Moreover, resveratrol (RSV), a plant derived polyphenol, was shown to increase SIRT1 catalytic activity and mimics many aspects of CR in all eukaryotes tested. Resveratrol 10-21 sirtuin 1 Homo sapiens 79-84 21932511-3 2011 Moreover, resveratrol (RSV), a plant derived polyphenol, was shown to increase SIRT1 catalytic activity and mimics many aspects of CR in all eukaryotes tested. Resveratrol 23-26 sirtuin 1 Homo sapiens 79-84 20872255-0 2011 Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARgamma1-3 mRNA expression in human visceral adipocytes. Resveratrol 0-11 sirtuin 1 Homo sapiens 24-29 20872255-5 2011 This study was undertaken to investigate whether resveratrol can regulate SIRT1, FOXO1, adiponectin, PPARgamma1-3, and PPARbeta/delta in human AT. Resveratrol 49-60 sirtuin 1 Homo sapiens 74-79 20872255-5 2011 This study was undertaken to investigate whether resveratrol can regulate SIRT1, FOXO1, adiponectin, PPARgamma1-3, and PPARbeta/delta in human AT. Resveratrol 49-60 peroxisome proliferator activated receptor delta Homo sapiens 119-127 20872255-8 2011 RESULTS: Ours results show that resveratrol modulates the studied genes, increasing SIRT1 (p = 0.021), FOXO1 (p = 0.001), and adiponectin (p = 0.025) mRNA expression and decreasing PPARgamma1-3 (p = 0.003) mRNA in human visceral adipocytes. Resveratrol 32-43 sirtuin 1 Homo sapiens 84-89 20740479-4 2011 RSV and its analogues inhibited, albeit differentially, the protein and mRNA expression levels of inducible cell adhesion molecules, ICAM-1 and VCAM-1, in cultured endothelial cells. Resveratrol 0-3 intercellular adhesion molecule 1 Homo sapiens 133-139 21163946-0 2011 Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. Resveratrol 0-11 sirtuin 1 Homo sapiens 109-114 21163946-11 2011 Conversely, inhibition of SIRT1 achieved either by expression of an inactive mutant or by using the EX-527 inhibitor, both abolished resveratrol effects on glucose responses. Resveratrol 133-144 sirtuin 1 Homo sapiens 26-31 21339330-2 2011 Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). Resveratrol 26-37 sirtuin 1 Homo sapiens 107-116 21339330-2 2011 Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). Resveratrol 26-37 sirtuin 1 Homo sapiens 118-123 21149440-10 2011 Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression. Resveratrol 10-21 sirtuin 1 Homo sapiens 55-60 21149440-10 2011 Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression. Resveratrol 10-21 sirtuin 1 Homo sapiens 88-93 21118843-6 2011 SIRT1 activator resveratrol decreased, whereas endogenous SIRT1 inhibitor nicotinamide increased Nox1 expression in A7r5 VSMCs. Resveratrol 16-27 sirtuin 1 Homo sapiens 0-5 21062970-0 2011 Spontaneous mutagenesis in Csb(m/m)Ogg1-(/)- mice is attenuated by dietary resveratrol. Resveratrol 75-86 8-oxoguanine DNA-glycosylase 1 Mus musculus 35-39 21062970-3 2011 Here, we describe that the phytoalexin resveratrol, applied either for 7 days per gavage (100 mg/kg body wt) or for 3-9 months in the diet (0.04% ad libitum), reduces the endogenous oxidative DNA base damage in the livers of the Csb(m/m)Ogg1-(/)- mice by 20-30% (P < 0.01). Resveratrol 39-50 8-oxoguanine DNA-glycosylase 1 Mus musculus 237-241 21062970-5 2011 The spontaneous mutation frequencies determined in the lacI gene of BigBlue Csb(m/m)Ogg1-(/)- mice are concomitantly reduced by resveratrol to similar extents. Resveratrol 129-140 8-oxoguanine DNA-glycosylase 1 Mus musculus 85-89 21187340-7 2011 Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53. Resveratrol 113-124 tumor protein p53 inducible protein 3 Homo sapiens 252-256 21205742-0 2011 Resveratrol-induced apoptosis is mediated by early growth response-1, Kruppel-like factor 4, and activating transcription factor 3. Resveratrol 0-11 Kruppel like factor 4 Homo sapiens 70-91 21205742-5 2011 Analysis of the ATF3 promoter revealed the importance of early growth response-1 (Egr-1; located at -245 to -236) and Kruppel-like factor 4 (KLF4; located at -178 to -174) putative binding sites in resveratrol-mediated ATF3 transactivation. Resveratrol 198-209 Kruppel like factor 4 Homo sapiens 118-139 21205742-5 2011 Analysis of the ATF3 promoter revealed the importance of early growth response-1 (Egr-1; located at -245 to -236) and Kruppel-like factor 4 (KLF4; located at -178 to -174) putative binding sites in resveratrol-mediated ATF3 transactivation. Resveratrol 198-209 Kruppel like factor 4 Homo sapiens 141-145 21205742-7 2011 Resveratrol increased Egr-1 and KLF4 expression, which preceded ATF3 expression, and further suggests Egr-1 and KLF4 involvement in resveratrol-mediated activity. Resveratrol 0-11 Kruppel like factor 4 Homo sapiens 32-36 21205742-7 2011 Resveratrol increased Egr-1 and KLF4 expression, which preceded ATF3 expression, and further suggests Egr-1 and KLF4 involvement in resveratrol-mediated activity. Resveratrol 132-143 Kruppel like factor 4 Homo sapiens 112-116 21205742-8 2011 We provide evidence for Egr-1 and KLF4 interaction in the presence of resveratrol, which may facilitate ATF3 transcriptional regulation by this compound. Resveratrol 70-81 Kruppel like factor 4 Homo sapiens 34-38 21778691-0 2011 Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson"s disease. Resveratrol 0-11 sirtuin 1 Homo sapiens 27-32 21778691-6 2011 We found that suppression of AMPK and/or SIRT1 caused decrease of protein level of LC3-II, indicating that AMPK and/or SIRT1 are required in resveratrol-mediated autophagy induction. Resveratrol 141-152 sirtuin 1 Homo sapiens 41-46 21778691-6 2011 We found that suppression of AMPK and/or SIRT1 caused decrease of protein level of LC3-II, indicating that AMPK and/or SIRT1 are required in resveratrol-mediated autophagy induction. Resveratrol 141-152 sirtuin 1 Homo sapiens 119-124 21778691-7 2011 Moreover, suppression of AMPK caused inhibition of SIRT1 activity and attenuated protective effects of resveratrol on rotenone-induced apoptosis, further suggesting that AMPK-SIRT1-autophagy pathway plays an important role in the neuroprotection by resveratrol on PD cellular models. Resveratrol 103-114 sirtuin 1 Homo sapiens 175-180 21778691-7 2011 Moreover, suppression of AMPK caused inhibition of SIRT1 activity and attenuated protective effects of resveratrol on rotenone-induced apoptosis, further suggesting that AMPK-SIRT1-autophagy pathway plays an important role in the neuroprotection by resveratrol on PD cellular models. Resveratrol 249-260 sirtuin 1 Homo sapiens 175-180 22301921-4 2011 By interfering Gli1 expression in PANC-1 cells and overexpressing Gli1 in BxPC-3 cells, we detected the expressions of Gli1-targeted genes, such as Ptc1, CCND1 and BCL-2, compared with resveratrol experimental group. Resveratrol 185-196 GLI family zinc finger 1 Homo sapiens 15-19 22301921-4 2011 By interfering Gli1 expression in PANC-1 cells and overexpressing Gli1 in BxPC-3 cells, we detected the expressions of Gli1-targeted genes, such as Ptc1, CCND1 and BCL-2, compared with resveratrol experimental group. Resveratrol 185-196 GLI family zinc finger 1 Homo sapiens 66-70 22301921-4 2011 By interfering Gli1 expression in PANC-1 cells and overexpressing Gli1 in BxPC-3 cells, we detected the expressions of Gli1-targeted genes, such as Ptc1, CCND1 and BCL-2, compared with resveratrol experimental group. Resveratrol 185-196 GLI family zinc finger 1 Homo sapiens 66-70 22301921-5 2011 We further used the luciferase reporter assay to explore the correlation between resveratrol and Gli1. Resveratrol 81-92 GLI family zinc finger 1 Homo sapiens 97-101 22301921-8 2011 Low concentration of resveratrol decreased the expression of the Hedgehog pathway members including Gli1, Ptc1 and Smo. Resveratrol 21-32 GLI family zinc finger 1 Homo sapiens 100-104 22301921-9 2011 The expression of downstream target genes of the Hedgehog pathway such as Gli1, Ptc1, CCND1 and BCL-2 were significantly decreased after 12.5 muM resveratrol treatment, which demonstrated a similar change of gene expression when Gli1 was knocked down by the RNAi technique in PANC-1 cells. Resveratrol 146-157 GLI family zinc finger 1 Homo sapiens 74-78 22301921-9 2011 The expression of downstream target genes of the Hedgehog pathway such as Gli1, Ptc1, CCND1 and BCL-2 were significantly decreased after 12.5 muM resveratrol treatment, which demonstrated a similar change of gene expression when Gli1 was knocked down by the RNAi technique in PANC-1 cells. Resveratrol 146-157 GLI family zinc finger 1 Homo sapiens 229-233 22301921-10 2011 Resveratrol also downregulated the expression of Gli1, Ptc1, CCND1 and BCL-2 in Gli1-overexpressed BxPC-3 cells. Resveratrol 0-11 GLI family zinc finger 1 Homo sapiens 49-53 22301921-10 2011 Resveratrol also downregulated the expression of Gli1, Ptc1, CCND1 and BCL-2 in Gli1-overexpressed BxPC-3 cells. Resveratrol 0-11 GLI family zinc finger 1 Homo sapiens 80-84 22220203-8 2011 These findings strongly implicate that iNOS is involved in the Abeta-induced lipid peroxidation and HO-1 downregulation, and resveratrol protects animals from Abeta-induced neurotoxicity by suppressing iNOS production. Resveratrol 125-136 amyloid beta precursor protein Rattus norvegicus 159-164 22242130-7 2011 Resveratrol inhibited mTOR self-phosphorylation and the phosphorylation of mTOR targets S6K1 and eIF4E-BP1. Resveratrol 0-11 mechanistic target of rapamycin kinase Rattus norvegicus 22-26 22242130-7 2011 Resveratrol inhibited mTOR self-phosphorylation and the phosphorylation of mTOR targets S6K1 and eIF4E-BP1. Resveratrol 0-11 mechanistic target of rapamycin kinase Rattus norvegicus 75-79 22242130-11 2011 We conclude that resveratrol is an inhibitor of global protein synthesis, and that this effect is mediated through modulation of mTOR-dependent and independent signaling. Resveratrol 17-28 mechanistic target of rapamycin kinase Rattus norvegicus 129-133 21980390-14 2011 Finally, resveratrol-treated mice showed significant inhibition in tumor growth which was associated with reduced phosphorylation of ERK, PI3K, AKT, FOXO1 and FOXO3a, and induction of apoptosis and FOXO target genes. Resveratrol 9-20 forkhead box O3 Mus musculus 159-165 21695150-6 2011 Rsv induced the formation of autophagosomes in three human GBM cell lines, accompanied by an upregulation of autophagy proteins Atg5, beclin-1 and LC3-II. Resveratrol 0-3 beclin 1 Homo sapiens 134-142 21209944-0 2010 Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. Resveratrol 0-11 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 43-48 21209944-2 2010 We have recently shown that resveratrol can enhance the apoptosis-inducing potential of TRAIL in prostate cancer cells through multiple mechanisms in vitro. Resveratrol 28-39 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 88-93 21078299-4 2010 Treatment of primary cultured hepatocytes with resveratrol increased insulin-repressed PEPCK and G6Pase mRNA levels, which depend on SIRT1 activity. Resveratrol 47-58 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 87-92 21078299-4 2010 Treatment of primary cultured hepatocytes with resveratrol increased insulin-repressed PEPCK and G6Pase mRNA levels, which depend on SIRT1 activity. Resveratrol 47-58 sirtuin 1 Homo sapiens 133-138 21078299-5 2010 We found that the resveratrol treatment resulted in a decrease in the phosphorylation of Akt and FOXO1, which are independent of SIRT1 action. Resveratrol 18-29 sirtuin 1 Homo sapiens 129-134 21078299-8 2010 Our results indicate that resveratrol upregulates the expression of gluconeogenic genes by attenuating insulin signaling and by deacetylating FOXO1, which are SIRT1-independent in the cytosol and SIRT1-dependent in the nucleus, respectively. Resveratrol 26-37 sirtuin 1 Homo sapiens 159-164 21078299-8 2010 Our results indicate that resveratrol upregulates the expression of gluconeogenic genes by attenuating insulin signaling and by deacetylating FOXO1, which are SIRT1-independent in the cytosol and SIRT1-dependent in the nucleus, respectively. Resveratrol 26-37 sirtuin 1 Homo sapiens 196-201 20943792-8 2010 Quercetin attenuated TNF-alpha-mediated phosphorylation of extracellular signal-related kinase and c-Jun-NH2 terminal kinase, whereas trans-RSV attenuated only c-Jun-NH2 terminal kinase phosphorylation. Resveratrol 134-143 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 160-165 20943792-9 2010 Quercetin and trans-RSV attenuated TNF-alpha-mediated phosphorylation of c-Jun and degradation of inhibitory kappaB protein. Resveratrol 14-23 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 73-78 20812964-6 2010 The known agonists of Sirt1, resveratrol and metformin, also significantly inhibited MMP-9 expression and appeared to protect collagen from degradation after UVR. Resveratrol 29-40 sirtuin 1 Homo sapiens 22-27 20812964-6 2010 The known agonists of Sirt1, resveratrol and metformin, also significantly inhibited MMP-9 expression and appeared to protect collagen from degradation after UVR. Resveratrol 29-40 matrix metallopeptidase 9 Homo sapiens 85-90 20797428-0 2010 Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation. Resveratrol 0-11 myocardin Homo sapiens 39-48 20797428-7 2010 In an effort to identify the molecular mechanisms whereby RSVL represses VSMC differentiation, we found that RSVL inhibits the transcription of Myocardin (myocd) and Srf, the key VSMC transcriptional regulators. Resveratrol 58-62 myocardin Homo sapiens 144-153 20797428-7 2010 In an effort to identify the molecular mechanisms whereby RSVL represses VSMC differentiation, we found that RSVL inhibits the transcription of Myocardin (myocd) and Srf, the key VSMC transcriptional regulators. Resveratrol 58-62 serum response factor Homo sapiens 166-169 20797428-7 2010 In an effort to identify the molecular mechanisms whereby RSVL represses VSMC differentiation, we found that RSVL inhibits the transcription of Myocardin (myocd) and Srf, the key VSMC transcriptional regulators. Resveratrol 109-113 myocardin Homo sapiens 144-153 20797428-7 2010 In an effort to identify the molecular mechanisms whereby RSVL represses VSMC differentiation, we found that RSVL inhibits the transcription of Myocardin (myocd) and Srf, the key VSMC transcriptional regulators. Resveratrol 109-113 serum response factor Homo sapiens 166-169 20797428-9 2010 This study provides the first evidence showing that RSVL induces VSMC dedifferentiation by regulating Myocardin and SRF-mediated VSMC gene transcription. Resveratrol 52-56 myocardin Homo sapiens 102-111 20797428-9 2010 This study provides the first evidence showing that RSVL induces VSMC dedifferentiation by regulating Myocardin and SRF-mediated VSMC gene transcription. Resveratrol 52-56 serum response factor Homo sapiens 116-119 20626250-3 2010 We hypothesized that resveratrol (RSV), a polyphenolic molecule that enhances mammalian NAD(+)-dependent SIRT1 deacetylases and may increase life span, would improve motor function and survival in the SOD1 mouse model via modulation of p53 acetylation. Resveratrol 21-32 sirtuin 1 Homo sapiens 105-110 20626250-3 2010 We hypothesized that resveratrol (RSV), a polyphenolic molecule that enhances mammalian NAD(+)-dependent SIRT1 deacetylases and may increase life span, would improve motor function and survival in the SOD1 mouse model via modulation of p53 acetylation. Resveratrol 34-37 sirtuin 1 Homo sapiens 105-110 20644332-0 2010 Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation. Resveratrol 0-11 sirtuin 1 Homo sapiens 97-102 20644332-3 2010 Resveratrol (RV)-induced SirT1 activation also improves endothelial dysfunction and suppresses vascular inflammation. Resveratrol 0-11 sirtuin 1 Homo sapiens 25-30 20644332-3 2010 Resveratrol (RV)-induced SirT1 activation also improves endothelial dysfunction and suppresses vascular inflammation. Resveratrol 13-15 sirtuin 1 Homo sapiens 25-30 20651248-5 2010 Resveratrol, an activator of the Nicotinamide adenine dinucleotide (NAD) dependent protein deacetylase SIRT1, reversed acetylation but not phosphorylation of Smad3 and inhibited TGF-beta1-induced up-regulation of collagen IV and fibronectin mRNA levels. Resveratrol 0-11 sirtuin 1 Homo sapiens 103-108 20848560-1 2010 The natural phytocompound resveratrol has been considered for many years a potential anticancer drug, but recently it has come to the attention of neuroscientist too, as it displays neuroprotective actions and activates the sirtuins" family member SIRT1. Resveratrol 26-37 sirtuin 1 Homo sapiens 248-253 23554653-10 2010 The molecular mechanism by which resveratrol inhibited iNOS gene expression appeared to involve increased PPAR-gamma activity, which resulted in the inhibition of NF-kappaB activation. Resveratrol 33-44 peroxisome proliferator-activated receptor gamma Rattus norvegicus 106-116 20507922-5 2010 Resveratrol supplementation blunted the exercise-induced increase in xanthine oxidase activity in muscles from young (25%) and aged (53%) mice. Resveratrol 0-11 xanthine dehydrogenase Mus musculus 69-85 20461740-7 2010 Resveratrol significantly inhibited HO-1-mediated MMP-9 (35% inhibition) and MMP-2 (28% inhibition) expression in lung cancer cells. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 50-55 20461740-10 2010 Our results suggest that resveratrol inhibited HO-1 and subsequently MMP-9 and MMP-2 expression in lung cancer cells. Resveratrol 25-36 matrix metallopeptidase 9 Homo sapiens 69-74 20085812-4 2010 In mammals, the mammalian SIR2 ortholog SIRT1 has been most studied, and small molecule SIRT1 activators (STACs), including a plant-derived polyphenolic compound resveratrol, have been developed. Resveratrol 162-173 sirtuin 1 Homo sapiens 88-93 20117814-0 2010 Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Resveratrol 58-69 heme oxygenase 1 Rattus norvegicus 39-54 20117814-3 2010 The aim of this study is to elucidate whether Akt/HO-1 plays any role in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Resveratrol 73-84 heme oxygenase 1 Rattus norvegicus 50-54 20117814-9 2010 Resveratrol treatment also increased hepatic Akt activation and HO-1 expression as compared with vehicle-treated trauma hemorrhaged rats. Resveratrol 0-11 heme oxygenase 1 Rattus norvegicus 64-68 20117814-11 2010 CONCLUSION: These findings collectively suggest that the salutary effects of resveratrol administration on attenuation of hepatic injury after trauma hemorrhage are likely mediated via up-regulation of Akt-dependent HO-1 expression. Resveratrol 77-88 heme oxygenase 1 Rattus norvegicus 216-220 20097879-0 2010 Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. Resveratrol 51-62 sirtuin 1 Homo sapiens 77-82 20097879-1 2010 The phytochemical resveratrol has recently gained attention for its protection against metabolic disease and for extension of life span, which have been linked to its metabolic effects and SIRT1 activation in fat cells. Resveratrol 18-29 sirtuin 1 Homo sapiens 189-194 20097879-3 2010 Here, we identify a novel, SIRT1-independent mechanism by which resveratrol regulates fat cell numbers. Resveratrol 64-75 sirtuin 1 Homo sapiens 27-32 20097879-7 2010 The synergistic interaction of resveratrol and TRAIL depends on the intrinsic apoptosis pathway and caspases, since Bcl-2 overexpression and the caspase inhibitor zVAD.fmk inhibit apoptosis, whereas knockdown of SIRT1 by RNA interference has no effect. Resveratrol 31-42 sirtuin 1 Homo sapiens 212-217 20348297-1 2010 Resveratrol synthesis from p-coumarate was analyzed in different Saccharomyces cerevisiae strains expressing the 4-coumaroyl-coenzyme A ligase (4CL1) from Arabidopsis thaliana and the stilbene synthase (STS) from Vitis vinifera and compared between yeast cultures growing in rich or synthetic medium. Resveratrol 0-11 stachyose synthase Arabidopsis thaliana 184-201 20132235-2 2010 It has been reported that resveratrol exerts the inhibitory effects on aging through activation of sirtuin 1 (SIRT1) and dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric dimethylarginine (ADMA) pathway involved in the high glucose-induced endothelial cell senescence. Resveratrol 26-37 sirtuin 1 Homo sapiens 99-108 20132235-2 2010 It has been reported that resveratrol exerts the inhibitory effects on aging through activation of sirtuin 1 (SIRT1) and dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric dimethylarginine (ADMA) pathway involved in the high glucose-induced endothelial cell senescence. Resveratrol 26-37 sirtuin 1 Homo sapiens 110-115 19969063-11 2010 Interestingly, resveratrol, an AhR antagonist, protected the cells from TCDD-induced hypertrophy. Resveratrol 15-26 aryl hydrocarbon receptor Rattus norvegicus 31-34 19969063-12 2010 In conclusion, AhR ligands caused a hypertrophic effect in H9c2 cells which was associated with induction of several CYP genes which can be prevented by resveratrol. Resveratrol 153-164 aryl hydrocarbon receptor Rattus norvegicus 15-18 20080969-2 2010 The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK). Resveratrol 23-34 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 157-161 20080969-5 2010 Here we show that AMPK signaling controls Abeta metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons. Resveratrol 105-116 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 18-22 20080969-6 2010 Resveratrol increased cytosolic calcium levels and promoted AMPK activation by the calcium/calmodulin-dependent protein kinase kinase-beta. Resveratrol 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 60-64 20080969-6 2010 Resveratrol increased cytosolic calcium levels and promoted AMPK activation by the calcium/calmodulin-dependent protein kinase kinase-beta. Resveratrol 0-11 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 83-138 20080969-7 2010 Direct pharmacological and genetic activation of AMPK lowered extracellular Abeta accumulation, whereas AMPK inhibition reduced the effect of resveratrol on Abeta levels. Resveratrol 142-153 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 104-108 20080969-8 2010 Furthermore, resveratrol inhibited the AMPK target mTOR (mammalian target of rapamycin) to trigger autophagy and lysosomal degradation of Abeta. Resveratrol 13-24 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 39-43 20080969-9 2010 Finally, orally administered resveratrol in mice was detected in the brain where it activated AMPK and reduced cerebral Abeta levels and deposition in the cortex. Resveratrol 29-40 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 94-98 20026255-2 2010 A commonly cited mechanism of resveratrol action is via the activation of the longevity factor Sir2/Sirt1, whose deacetylase activity on several transcription factors has stress resistance and pro-survival effects. Resveratrol 30-41 sirtuin 1 Homo sapiens 95-99 20026255-2 2010 A commonly cited mechanism of resveratrol action is via the activation of the longevity factor Sir2/Sirt1, whose deacetylase activity on several transcription factors has stress resistance and pro-survival effects. Resveratrol 30-41 sirtuin 1 Homo sapiens 100-105 20026255-3 2010 Resveratrol has been shown to be beneficial in various in vitro and in vivo models of central nervous system (CNS) neuron death and degeneration, presumably acting through Sirt1. Resveratrol 0-11 sirtuin 1 Homo sapiens 172-177 20026255-9 2010 Furthermore, resveratrol may indirectly increase Sirt1 activity in recovering or spared cells via AMPK"s elevation of NAD levels, which then translates into an overall beneficial outcome. Resveratrol 13-24 sirtuin 1 Homo sapiens 49-54 20089851-7 2010 Nuclear but not cytoplasmic SIRT1-induced manganese superoxide dismutase (Mn-SOD), which was further enhanced by resveratrol, and increased the resistance of C2C12 myoblasts to oxidative stress. Resveratrol 113-124 sirtuin 1 Homo sapiens 28-33 20089851-8 2010 Resveratrol"s enhancement of Mn-SOD levels depended on the level of nuclear SIRT1, and it suppressed the cell death induced by antimycin A or angiotensin II. Resveratrol 0-11 sirtuin 1 Homo sapiens 76-81 20089851-9 2010 The cell-protective effects of nuclear SIRT1 or resveratrol were canceled by the Mn-SOD small interfering RNA or SIRT1 small interfering RNA. Resveratrol 48-59 sirtuin 1 Homo sapiens 113-118 20089851-11 2010 Thus, Mn-SOD induced by resveratrol via nuclear SIRT1 reduced oxidative stress and participated in cardiomyocyte protection. Resveratrol 24-35 sirtuin 1 Homo sapiens 48-53 20089851-12 2010 SIRT1 activators such as resveratrol could be novel therapeutic tools for the treatment of chronic heart failure. Resveratrol 25-36 sirtuin 1 Homo sapiens 0-5 20131808-7 2010 Upon incubation of PMA-treated HepG2 cells with resveratrol (0-50 microM) or MR-3 (0-50 microM), the MMP-9 activity decreased but TIMP-1 protein increased in a dose-dependent manner. Resveratrol 48-59 matrix metallopeptidase 9 Homo sapiens 101-106 20131808-8 2010 With resveratrol (0-50 microM) or MR-3 (0-1 microM) treatment on PMA-untreated Hep3B cells, both of the MMP-9 and MMP-2 activities decreased but TIMP-2 protein increased in a dose-dependent manner. Resveratrol 5-16 matrix metallopeptidase 9 Homo sapiens 104-109 20131808-8 2010 With resveratrol (0-50 microM) or MR-3 (0-1 microM) treatment on PMA-untreated Hep3B cells, both of the MMP-9 and MMP-2 activities decreased but TIMP-2 protein increased in a dose-dependent manner. Resveratrol 5-16 TIMP metallopeptidase inhibitor 2 Homo sapiens 145-151 20131808-9 2010 These results suggest that resveratrol and its related methoxy analogue MR-3 might exert anti-invasive activity against hepatoma cells through regulation of MMP-2, MMP-9, TIMP-1, and TIMP-2. Resveratrol 27-38 matrix metallopeptidase 9 Homo sapiens 164-169 20131808-9 2010 These results suggest that resveratrol and its related methoxy analogue MR-3 might exert anti-invasive activity against hepatoma cells through regulation of MMP-2, MMP-9, TIMP-1, and TIMP-2. Resveratrol 27-38 TIMP metallopeptidase inhibitor 2 Homo sapiens 183-189 20131808-10 2010 Further analysis with semiquantitative RT-PCR showed that the regulation of MMP-9 and TIMP-2 expressions by resveratrol and MR-3 in hepatoma cells may be on the transcriptional level but on the translational or post-translational level for TIMP-1. Resveratrol 108-119 matrix metallopeptidase 9 Homo sapiens 76-81 20131808-10 2010 Further analysis with semiquantitative RT-PCR showed that the regulation of MMP-9 and TIMP-2 expressions by resveratrol and MR-3 in hepatoma cells may be on the transcriptional level but on the translational or post-translational level for TIMP-1. Resveratrol 108-119 TIMP metallopeptidase inhibitor 2 Homo sapiens 86-92 20008278-3 2010 This study was designed to examine the effect of resveratrol (RSV), a potent activator of SIRT1, on cardiac function and SERCA2a expression in chronic type 1 diabetes. Resveratrol 49-60 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 121-128 20008278-3 2010 This study was designed to examine the effect of resveratrol (RSV), a potent activator of SIRT1, on cardiac function and SERCA2a expression in chronic type 1 diabetes. Resveratrol 62-65 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 121-128 20008278-5 2010 STZ administration produced progressive decline in cardiac function, associated with markedly reduced SERCA2a and SIRT1 protein levels and increased collagen deposition; RSV treatment to these mice had a tremendous beneficial effect both in terms of improving SERCA2a expression and on cardiac function. Resveratrol 170-173 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 260-267 20008278-6 2010 In cultured cardiomyocytes, RSV restored SERCA2 promoter activity, which was otherwise highly repressed in high-glucose media. Resveratrol 28-31 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 41-47 20008278-11 2010 The data demonstrate that, in chronic diabetes, 1) the enzymatic activity of cardiac SIRT1 is reduced, which contributes to reduced expression of SERCA2a and 2) through activation of SIRT1, RSV enhances expression of SERCA2a and improves cardiac function. Resveratrol 190-193 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 146-159 20008278-11 2010 The data demonstrate that, in chronic diabetes, 1) the enzymatic activity of cardiac SIRT1 is reduced, which contributes to reduced expression of SERCA2a and 2) through activation of SIRT1, RSV enhances expression of SERCA2a and improves cardiac function. Resveratrol 190-193 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 146-153 20028942-7 2010 Moreover, resveratrol treatment of hyperglycemic IRS2(-/-) mice decreased hepatic PTP1B mRNA and inhibited PTP1B activity, thereby restoring IRS1-mediated PI 3-kinase/Akt/Foxo1 signaling and peripheral insulin sensitivity. Resveratrol 10-21 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 82-87 20028942-7 2010 Moreover, resveratrol treatment of hyperglycemic IRS2(-/-) mice decreased hepatic PTP1B mRNA and inhibited PTP1B activity, thereby restoring IRS1-mediated PI 3-kinase/Akt/Foxo1 signaling and peripheral insulin sensitivity. Resveratrol 10-21 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 107-112 20190133-0 2010 SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Resveratrol 75-86 sirtuin 1 Homo sapiens 0-5 20103647-0 2010 Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Resveratrol 0-11 sequestosome 1 Homo sapiens 98-101 20103647-0 2010 Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Resveratrol 0-11 sequestosome 1 Homo sapiens 102-108 20103647-3 2010 Here, we report that the plant phytoalexin resveratrol (RSV) triggers autophagy in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia (CML) cells via JNK-dependent accumulation of p62. Resveratrol 43-54 sequestosome 1 Homo sapiens 200-203 20103647-3 2010 Here, we report that the plant phytoalexin resveratrol (RSV) triggers autophagy in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia (CML) cells via JNK-dependent accumulation of p62. Resveratrol 56-59 sequestosome 1 Homo sapiens 200-203 20103647-4 2010 JNK inhibition or p62 knockdown prevented RSV-mediated autophagy and antileukemic effects. Resveratrol 42-45 sequestosome 1 Homo sapiens 18-21 20103647-7 2010 Lastly, p62 expression and autophagy in CD34+ progenitors from patients with CML was induced by RSV, and disrupting autophagy protected CD34+ CML cells from RSV-mediated cell death. Resveratrol 96-99 sequestosome 1 Homo sapiens 8-11 20103647-7 2010 Lastly, p62 expression and autophagy in CD34+ progenitors from patients with CML was induced by RSV, and disrupting autophagy protected CD34+ CML cells from RSV-mediated cell death. Resveratrol 157-160 sequestosome 1 Homo sapiens 8-11 20103647-8 2010 We concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AMPK activation. Resveratrol 18-21 sequestosome 1 Homo sapiens 89-92 20103723-6 2010 All combinations of resveratrol with other compounds showed a synergistic effect on hyperplasia and Ha-ras mutations. Resveratrol 20-31 Harvey rat sarcoma virus oncogene Mus musculus 100-106 19815564-0 2010 Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Resveratrol 23-34 sirtuin 1 Homo sapiens 14-19 19815564-1 2010 AIMS: Resveratrol activates Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase which modulates metabolic homeostasis and improves several pathophysiological features present in diseases of ageing. Resveratrol 6-17 sirtuin 1 Homo sapiens 28-37 19815564-1 2010 AIMS: Resveratrol activates Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase which modulates metabolic homeostasis and improves several pathophysiological features present in diseases of ageing. Resveratrol 6-17 sirtuin 1 Homo sapiens 39-44 19815564-5 2010 METHODS AND RESULTS: We demonstrate that SIRT1 activation by resveratrol increases the expression of the transcription factor Kruppel-like factor 2 (KLF2) in human vascular endothelial cells, resulting in the orchestrated regulation of transcriptional programs critical for conferring an endothelial vasoprotective phenotype. Resveratrol 61-72 sirtuin 1 Homo sapiens 41-46 21086752-5 2010 Both resveratrol (5 mg kg(-1) day(-1)) and vitamin E (80 mg kg(-1) day(-1)) treatment significantly reduced AST, ALT, GST, IL-10, TNF-alpha, IFN-gamma, VEGF-A and TGF-beta1 activities and levels of TBARS and nitrite, and elevated albumin content, GSH level and activities of SOD, CAT, GR and GPx, compared to ethanol-treated group. Resveratrol 5-16 vascular endothelial growth factor A Mus musculus 152-158 20014068-0 2010 Resveratrol derivative, trans-3,5,4"-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. Resveratrol 0-11 kinase insert domain receptor like Danio rerio 154-160 20014068-3 2010 The aim of this study was to evaluate the antiangiogenic activity of resveratrol and its derivative trans-3,5,4"-trimethoxystilbene in vitro using human umbilical vein endothelial cells (HUVECs) and in vivo using transgenic zebrafish, and to clarify their mechanisms of action in zebrafish by gene expression analysis of the vascular endothelial growth factor (VEGF) receptor (VEGFR2/KDR) and cell-cycle analysis. Resveratrol 69-80 kinase insert domain receptor like Danio rerio 377-383 20014068-3 2010 The aim of this study was to evaluate the antiangiogenic activity of resveratrol and its derivative trans-3,5,4"-trimethoxystilbene in vitro using human umbilical vein endothelial cells (HUVECs) and in vivo using transgenic zebrafish, and to clarify their mechanisms of action in zebrafish by gene expression analysis of the vascular endothelial growth factor (VEGF) receptor (VEGFR2/KDR) and cell-cycle analysis. Resveratrol 69-80 kinase insert domain receptor (a type III receptor tyrosine kinase) Danio rerio 384-387 19923004-4 2010 SIRT1 activity suppressed by the exogenous Zn(2+) can be fully recovered by the metal chelator EDTA but not by the activator resveratrol. Resveratrol 125-136 sirtuin 1 Homo sapiens 0-5 27274843-4 2016 RESULTS: Supplementation with resveratrol (2.0 mumol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos" PA from oocytes that underwent HS by increasing their glutathione (GSH) level, reducing reactive oxygen species (ROS) and up-regulating the expression of Sirtuin 1 (SIRT1). Resveratrol 30-41 sirtuin 1 Homo sapiens 307-316 27274843-4 2016 RESULTS: Supplementation with resveratrol (2.0 mumol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos" PA from oocytes that underwent HS by increasing their glutathione (GSH) level, reducing reactive oxygen species (ROS) and up-regulating the expression of Sirtuin 1 (SIRT1). Resveratrol 30-41 sirtuin 1 Homo sapiens 318-323 27064016-9 2016 Treatment with the protein tyrosine phosphatase (PTP) inhibitor pervanadate reversed the resveratrol-induced down-regulation of STAT3, thereby indicating a critical role for a PTP. Resveratrol 89-100 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 19-47 27064016-9 2016 Treatment with the protein tyrosine phosphatase (PTP) inhibitor pervanadate reversed the resveratrol-induced down-regulation of STAT3, thereby indicating a critical role for a PTP. Resveratrol 89-100 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 49-52 27064016-9 2016 Treatment with the protein tyrosine phosphatase (PTP) inhibitor pervanadate reversed the resveratrol-induced down-regulation of STAT3, thereby indicating a critical role for a PTP. Resveratrol 89-100 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 176-179 27016191-5 2016 Our data revealed that Resveratrol ameliorated rotenone-induced ER stress by downregulating CHOP and GRP78 genes expression and hampered caspase-3 activity in the brain of rotenone exposed rats. Resveratrol 23-34 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 101-106 27148684-3 2016 Sirtuin 1 and phosphodiesterases have so far been found as the direct molecular targets of resveratrol. Resveratrol 91-102 sirtuin 1 Homo sapiens 0-32 27138844-4 2016 In addition, resveratrol treatment abolished the Rac1-induced increases in the activity of the NADPH oxidase subunits p22-phox and reduced the activity of SOD2, while treatment with an AMPK inhibitor (compound C, 40 muM/day) had the opposite effect, in the fructose-fed rats. Resveratrol 13-24 superoxide dismutase 2 Rattus norvegicus 155-159 26465873-7 2016 SIRT1 activation by resveratrol augmented hyperoxia-induced death in cells with NRF2 deficiency. Resveratrol 20-31 sirtuin 1 Homo sapiens 0-5 25917875-4 2016 RSV treatment decreases STIM1 expression in a time-dependent manner and attenuates STIM1 association with TRPC1 and Orai1. Resveratrol 0-3 transient receptor potential cation channel subfamily C member 1 Homo sapiens 106-111 25917875-4 2016 RSV treatment decreases STIM1 expression in a time-dependent manner and attenuates STIM1 association with TRPC1 and Orai1. Resveratrol 0-3 ORAI calcium release-activated calcium modulator 1 Homo sapiens 116-121 27035424-3 2016 The present study aimed to measure the inhibitory effects of resveratrol and genistein on tumor necrosis factor (TNF)-alpha and matrix metalloproteinase (MMP)-9 concentration in patients with COPD. Resveratrol 61-72 matrix metallopeptidase 9 Homo sapiens 128-160 27035424-11 2016 All three factors were significantly reduced in lymphocytes treated with resveratrol and genistein, and the inhibitory effects of resveratrol on NF-kappaB, TNF-alpha and MMP-9 were more potent than the effects of genistein. Resveratrol 130-141 matrix metallopeptidase 9 Homo sapiens 170-175 27035424-12 2016 In conclusion, resveratrol and genistein may inhibit the NF-kappaB, TNF-alpha and MMP-9-associated pathways in patients with COPD. Resveratrol 15-26 matrix metallopeptidase 9 Homo sapiens 82-87 27035673-8 2016 Resveratrol increased the SIRT1 protein expression levels and decreased the number of GFAP-positive and Iba-1-positive cells in LPS-treated mice. Resveratrol 0-11 allograft inflammatory factor 1 Mus musculus 104-109 26677078-0 2016 Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina. Resveratrol 0-11 glutamate-ammonia ligase Rattus norvegicus 79-99 26677078-12 2016 RSV (10, 20, and 30 mmol/l) significantly inhibited the HG-induced decreases in glutamate uptake, GS activity, GLAST and GS expression (at least P < 0.05). Resveratrol 0-3 glutamate-ammonia ligase Rattus norvegicus 98-100 27145432-3 2016 Resveratrol (50 muM or 5-50 muM) inhibited the production of interleukin-10 and monocyte chemoattractant protein-1 in M2 macrophages, whereas it promoted that of transforming growth factor-beta1. Resveratrol 0-11 interleukin 10 Homo sapiens 61-75 26789275-7 2016 In all resveratrol-treated rats, a significant increase in dendritic length and spine density in pyramidal neurons of the PFC, CA1, and CA3 of DH was observed. Resveratrol 7-18 carbonic anhydrase 3 Rattus norvegicus 136-139 27136581-3 2016 More recently, resveratrol has also been shown to potentially target many mitochondrial metabolic pathways, including fatty acid beta-oxidation or oxidative phosphorylation, leading to the up-regulation of the energy metabolism via signaling pathways involving PGC-1alpha, SIRT1, and/or AMP-kinase, which are not yet fully delineated. Resveratrol 15-26 sirtuin 1 Homo sapiens 273-278 26953552-8 2016 Similar to the protective effect of USP22 knockdown, resveratrol (RSV) depressed not only high d-glucose- and USP22 overexpression-induced cytotoxicity, but also the secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1. Resveratrol 53-64 ubiquitin specific peptidase 22 Rattus norvegicus 110-115 26953552-8 2016 Similar to the protective effect of USP22 knockdown, resveratrol (RSV) depressed not only high d-glucose- and USP22 overexpression-induced cytotoxicity, but also the secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1. Resveratrol 66-69 ubiquitin specific peptidase 22 Rattus norvegicus 110-115 27098390-0 2016 Resveratrol enhances HBV replication through activating Sirt1-PGC-1alpha-PPARalpha pathway. Resveratrol 0-11 sirtuin 1 Homo sapiens 56-61 27098390-5 2016 We found that RSV activates Sirt1, which in turn deacetylates PGC-1alpha and subsequently increases the transcriptional activity of PPARalpha, leading to the enhanced HBV transcription and replication in vitro and in vivo. Resveratrol 14-17 sirtuin 1 Homo sapiens 28-33 27098390-7 2016 Taken together, this study identifies that RSV enhances HBV transcription and replication especially acting on the core promoter, which depends on Sirt1-PGC-1alpha-PPARalpha pathway. Resveratrol 43-46 sirtuin 1 Homo sapiens 147-152 27093858-10 2016 RESULTS: We found that resveratrol significantly attenuated trigeminal allodynia dose-dependently and decreased the increased expression of CGRP and c-Fos in the STN. Resveratrol 23-34 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 149-154 26873964-9 2016 Resveratrol treatment also attenuated the expression levels of C3 protein in cultured neonatal rat ventricular cardiomyocytes. Resveratrol 0-11 complement C3 Rattus norvegicus 63-65 26943043-2 2016 The purpose of this study was to determine MTA1- targeted chemopreventive and therapeutic efficacy of pterostilbene, a natural potent analog of resveratrol, in pre-clinical models of prostate cancer. Resveratrol 144-155 metastasis associated 1 Homo sapiens 43-47 26777630-10 2016 At a high concentration (100 muM), Resveratrol significantly inhibited all parameters analyzed except Syk phosphorylation. Resveratrol 35-46 spleen associated tyrosine kinase Homo sapiens 102-105 26801825-0 2016 Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Resveratrol 0-11 mechanistic target of rapamycin kinase Rattus norvegicus 139-143 26801825-3 2016 The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring oxidative stress parameters and phosphorylation of AKT/mTOR pathway in the rat hippocampus and prefrontal cortex (PFC) exposed to the chronic unpredictable mild stress (CUMS). Resveratrol 98-109 mechanistic target of rapamycin kinase Rattus norvegicus 178-182 26801825-8 2016 In conclusion, our study showed that resveratrol exerted antidepressant-like effects in CUMS rats, which was mediated in part by its antioxidant action, up-regulation of phosphor-Akt and mTOR levels in the hippocampus and PFC. Resveratrol 37-48 mechanistic target of rapamycin kinase Rattus norvegicus 187-191 27041235-6 2016 (2013) A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. Resveratrol 28-39 sirtuin 1 Homo sapiens 122-127 26502886-0 2016 Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Resveratrol 41-52 ATP binding cassette subfamily C member 2 Homo sapiens 92-96 26502886-9 2016 CONCLUSIONS: These results suggest that curcumin alters the phase II distribution of resveratrol through inhibiting efflux transporters including MRP2 and BCRP. Resveratrol 85-96 ATP binding cassette subfamily C member 2 Homo sapiens 146-150 26911335-0 2016 Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPepsilon and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. Resveratrol 0-11 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 99-104 26446263-7 2016 In addition, resveratrol stimulation upregulated the transcriptional activation potentials of the CRE-binding proteins (CREB) and activating transcription factor 2 (ATF2). Resveratrol 13-24 activating transcription factor 2 Homo sapiens 120-124 26446263-7 2016 In addition, resveratrol stimulation upregulated the transcriptional activation potentials of the CRE-binding proteins (CREB) and activating transcription factor 2 (ATF2). Resveratrol 13-24 activating transcription factor 2 Homo sapiens 130-163 26446263-7 2016 In addition, resveratrol stimulation upregulated the transcriptional activation potentials of the CRE-binding proteins (CREB) and activating transcription factor 2 (ATF2). Resveratrol 13-24 activating transcription factor 2 Homo sapiens 165-169 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 14-25 activating transcription factor 2 Homo sapiens 128-132 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 14-25 activating transcription factor 2 Homo sapiens 137-141 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 14-25 activating transcription factor 2 Homo sapiens 267-271 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 14-25 activating transcription factor 2 Homo sapiens 277-281 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 207-218 activating transcription factor 2 Homo sapiens 128-132 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 207-218 activating transcription factor 2 Homo sapiens 137-141 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 207-218 activating transcription factor 2 Homo sapiens 267-271 26446263-9 2016 The fact that resveratrol upregulates CRE-mediated gene transcription and enhances the transcriptional activation potentials of CREB and ATF2 suggests that cytoprotective and tumor suppressive activities of resveratrol may rely-at least in part-on the stimulation of CREB- and ATF2-controlled target genes. Resveratrol 207-218 activating transcription factor 2 Homo sapiens 277-281 26706021-7 2016 Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus, and metabolic syndrome, suggesting that it may augment BDNF synthesis and action. Resveratrol 0-11 brain derived neurotrophic factor Homo sapiens 130-134 26799794-8 2016 Thus, our study provides a mechanistic link between resveratrol and the activation of SIRT1, the latter of which is involved in resveratrol-mediated repression of the p38 MAPK/NF-kappaB pathway and ROS production in TNF-alpha-treated HUVECs. Resveratrol 52-63 sirtuin 1 Homo sapiens 86-91 26799794-8 2016 Thus, our study provides a mechanistic link between resveratrol and the activation of SIRT1, the latter of which is involved in resveratrol-mediated repression of the p38 MAPK/NF-kappaB pathway and ROS production in TNF-alpha-treated HUVECs. Resveratrol 128-139 sirtuin 1 Homo sapiens 86-91 26592738-7 2016 On the contrary, resveratrol, a mitochondrial nutrient, efficiently reversed dexamethasone-induced mitochondrial dysfunction and muscle atrophy in both C2C12 myotubes and mice, by improving mitochondrial function and blocking AMPK/FOXO3 signaling. Resveratrol 17-28 forkhead box O3 Mus musculus 231-236 26497626-10 2016 Specifically, resveratrol alone augmented HO-1 induction via Nrf2-mediated signaling. Resveratrol 14-25 heme oxygenase 1 Rattus norvegicus 42-46 26497626-13 2016 Furthermore, resveratrol suppressed LPS-mediated decreases in HO-1 and Nrf2 levels in the inflamed periodontal tissues. Resveratrol 13-24 heme oxygenase 1 Rattus norvegicus 62-66 27582325-0 2016 Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1. Resveratrol 0-11 sirtuin 1 Homo sapiens 111-116 26461115-4 2016 Antibody functionalized nanoparticles synthesized to deliver the antioxidant resveratrol are effective in reducing oxidative damage to DNA, AQP4 immunoreactivity and preserving visual function. Resveratrol 77-88 aquaporin 4 Homo sapiens 140-144 28116292-9 2016 These results indicate that rehabilitation raining plus resveratrol can significantly improve the recovery of motor function in rats after cerebral ischemic injury, which is likely related to the upregulation of the BDNF/TrkB signaling pathway. Resveratrol 56-67 brain-derived neurotrophic factor Rattus norvegicus 216-220 26445217-8 2016 High concentrations of resveratrol also increased LDL receptor expression, while all concentrations of resveratrol activated the histone deacetylase sirtuin1. Resveratrol 103-114 sirtuin 1 Homo sapiens 149-157 25207479-4 2016 In particular, resveratrol seems to play a positive effect on longevity because it increases the expression level of Sirt1, besides its antioxidant, anti-inflammatory and anticarcinogenic properties. Resveratrol 15-26 sirtuin 1 Homo sapiens 117-122 26781417-0 2016 [Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo]. Resveratrol 1-12 sirtuin 1 Homo sapiens 23-32 26781417-1 2016 OBJECTIVE: To explore the effect of resveratrol on the levels of sirtuin 1 (SIRT1) and reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) of premature infants exposed to hyperoxia. Resveratrol 36-47 sirtuin 1 Homo sapiens 65-74 26781417-1 2016 OBJECTIVE: To explore the effect of resveratrol on the levels of sirtuin 1 (SIRT1) and reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) of premature infants exposed to hyperoxia. Resveratrol 36-47 sirtuin 1 Homo sapiens 76-81 26781417-7 2016 RESULTS: Compared with the control group, the level of SIRT1 in the air+resveratrol group increased significantly (P<0.05). Resveratrol 72-83 sirtuin 1 Homo sapiens 55-60 26781417-9 2016 The levels of ROS and MDA and the SIRT1 transposition rate decreased significantly (P<0.05), and the expression level of SIRT1 increased significantly in the hyperoxia+resveratrol group (P<0.05). Resveratrol 171-182 sirtuin 1 Homo sapiens 124-129 26781417-10 2016 CONCLUSIONS: Resveratrol can increase SIRT1 expression in PBMCs and inhibit SIRT1 shuttle from nucleus to cytoplasm in order to increase the ability of antioxidative stress in premature infants exposed to hyperoxia, thereby reducing the oxidative stress injury in premature infants. Resveratrol 13-24 sirtuin 1 Homo sapiens 38-43 26781417-10 2016 CONCLUSIONS: Resveratrol can increase SIRT1 expression in PBMCs and inhibit SIRT1 shuttle from nucleus to cytoplasm in order to increase the ability of antioxidative stress in premature infants exposed to hyperoxia, thereby reducing the oxidative stress injury in premature infants. Resveratrol 13-24 sirtuin 1 Homo sapiens 76-81 32309575-3 2015 Indirect AMPK activators, such as resveratrol, metformin and exercise, are currently in clinical trials for studying their impact on human aging-related characteristics, tissue homeostasis and metabolic dysfunctions. Resveratrol 34-45 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 9-13 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 95-106 brain-derived neurotrophic factor Rattus norvegicus 142-175 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 95-106 brain-derived neurotrophic factor Rattus norvegicus 177-181 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 95-106 brain-derived neurotrophic factor Rattus norvegicus 223-227 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 108-111 brain-derived neurotrophic factor Rattus norvegicus 142-175 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 108-111 brain-derived neurotrophic factor Rattus norvegicus 177-181 26703578-1 2015 We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. Resveratrol 108-111 brain-derived neurotrophic factor Rattus norvegicus 223-227 26703578-3 2015 However, co-administration of Eth 0.25 g/kg BW/day and Rsv led to increased expression of BDNF exons I, III and IV and to a small but significant increase in the level of pro-BDNF protein in maternal rats. Resveratrol 55-58 brain-derived neurotrophic factor Rattus norvegicus 90-94 26703578-3 2015 However, co-administration of Eth 0.25 g/kg BW/day and Rsv led to increased expression of BDNF exons I, III and IV and to a small but significant increase in the level of pro-BDNF protein in maternal rats. Resveratrol 55-58 brain-derived neurotrophic factor Rattus norvegicus 175-179 26674205-0 2015 Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. Resveratrol 0-11 microRNA 34c Homo sapiens 64-71 26674205-0 2015 Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. Resveratrol 0-11 KIT ligand Homo sapiens 72-77 26468275-4 2015 A main finding of this investigation was the highly preferential binding of resveratrol and thyroxine, both characterized by negative binding cooperativity, to distinct sites in TTR, consistent with the data of x-ray analysis of TTR in complex with both ligands. Resveratrol 76-87 transthyretin Homo sapiens 178-181 26468275-4 2015 A main finding of this investigation was the highly preferential binding of resveratrol and thyroxine, both characterized by negative binding cooperativity, to distinct sites in TTR, consistent with the data of x-ray analysis of TTR in complex with both ligands. Resveratrol 76-87 transthyretin Homo sapiens 229-232 26667767-3 2015 Inhibitor of DNA binding 1 (ID1), histidine-rich glycoprotein (HRG), NADPH oxidase (NOX1) and sprouty homolog 1 (SPRY), were upregulated by LPS treatment, but significantly blocked by trans-resveratrol pre-treatment (padj< 0.05, after adjusting for Benjamini-Hocheberg procedure). Resveratrol 184-201 histidine rich glycoprotein Homo sapiens 34-61 26667767-3 2015 Inhibitor of DNA binding 1 (ID1), histidine-rich glycoprotein (HRG), NADPH oxidase (NOX1) and sprouty homolog 1 (SPRY), were upregulated by LPS treatment, but significantly blocked by trans-resveratrol pre-treatment (padj< 0.05, after adjusting for Benjamini-Hocheberg procedure). Resveratrol 184-201 histidine rich glycoprotein Homo sapiens 63-66 26667767-5 2015 Other genes involved in fat turnover, but also in cell death and survival function, such as transcription factors Kruppel-like factor 5 (KLF5) and amphiregulin (AREG), were also significantly inhibited by trans-resveratrol pre-treatment. Resveratrol 205-222 amphiregulin Homo sapiens 147-159 26667767-5 2015 Other genes involved in fat turnover, but also in cell death and survival function, such as transcription factors Kruppel-like factor 5 (KLF5) and amphiregulin (AREG), were also significantly inhibited by trans-resveratrol pre-treatment. Resveratrol 205-222 amphiregulin Homo sapiens 161-165 26522222-11 2015 In old rats treated with resveratrol, the expression levels of BDNF and TrkB were up-regulated. Resveratrol 25-36 brain-derived neurotrophic factor Rattus norvegicus 63-67 26629991-0 2015 Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway. Resveratrol 14-25 sirtuin 1 Homo sapiens 108-113 26629991-9 2015 Furthermore, we found that RSV or MET treatment prevented senescent "memory" by modulating SIRT1/p300/p53/p21 pathway. Resveratrol 27-30 sirtuin 1 Homo sapiens 91-96 26046675-0 2015 Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells. Resveratrol 0-11 X-ray repair cross complementing 1 Homo sapiens 100-137 26046675-0 2015 Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells. Resveratrol 0-11 X-ray repair cross complementing 1 Homo sapiens 139-144 26046675-7 2015 Resveratrol inhibited the expression of XRCC1 and enhanced the etoposide-induced cell death and anti-proliferation effect in NSCLC cells. Resveratrol 0-11 X-ray repair cross complementing 1 Homo sapiens 40-45 26457480-4 2015 Acrolein reacted with resveratrol at the C-2 and C-3 positions through nucleophilic addition and formed an additional heterocyclic ring. Resveratrol 22-33 complement C3 Homo sapiens 49-52 26456774-3 2015 Resveratrol induces p53-dependent apoptosis via plasma membrane integrin alphavbeta3. Resveratrol 0-11 integrin subunit alpha V Homo sapiens 64-84 26296578-8 2015 Resveratrol exerted a high, dose-dependent, antiviral activity against HRV-16 replication and reduced virus-induced secretion of IL-6, IL-8 and RANTES to levels similar to that of uninfected nasal epithelia. Resveratrol 0-11 C-C motif chemokine ligand 5 Homo sapiens 144-150 26296578-10 2015 HRV-induced expression of ICAM-1 was reversed by resveratrol. Resveratrol 49-60 intercellular adhesion molecule 1 Homo sapiens 26-32 26243699-0 2015 Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model. Resveratrol 69-80 vascular endothelial growth factor A Mus musculus 50-55 26243699-3 2015 Previously, authors of the present report demonstrated that cis-resveratrol (c-RSV)-induced heat-shock protein 70 (HSP70) promoter-regulated VEGFA expression promoted neovascularization of genetically modified mesenchymal stem cells (HSP-VEGFA-MSC) in a mouse model of ischemic disease. Resveratrol 60-75 vascular endothelial growth factor A Mus musculus 141-146 26243699-3 2015 Previously, authors of the present report demonstrated that cis-resveratrol (c-RSV)-induced heat-shock protein 70 (HSP70) promoter-regulated VEGFA expression promoted neovascularization of genetically modified mesenchymal stem cells (HSP-VEGFA-MSC) in a mouse model of ischemic disease. Resveratrol 60-75 vascular endothelial growth factor A Mus musculus 238-243 26243699-3 2015 Previously, authors of the present report demonstrated that cis-resveratrol (c-RSV)-induced heat-shock protein 70 (HSP70) promoter-regulated VEGFA expression promoted neovascularization of genetically modified mesenchymal stem cells (HSP-VEGFA-MSC) in a mouse model of ischemic disease. Resveratrol 77-82 vascular endothelial growth factor A Mus musculus 141-146 26243699-3 2015 Previously, authors of the present report demonstrated that cis-resveratrol (c-RSV)-induced heat-shock protein 70 (HSP70) promoter-regulated VEGFA expression promoted neovascularization of genetically modified mesenchymal stem cells (HSP-VEGFA-MSC) in a mouse model of ischemic disease. Resveratrol 77-82 vascular endothelial growth factor A Mus musculus 238-243 26243699-5 2015 Results of this study showed that c-RSV-treatment of HSP-VEGFA-MSC exhibited synergy between HSP70 transcription activity and induced expression of anti-oxidant-related genes when challenged by cigarette smoke extracts. Resveratrol 34-39 vascular endothelial growth factor A Mus musculus 57-62 26505388-0 2015 Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro. Resveratrol 0-11 sirtuin 1 Homo sapiens 44-49 26505388-5 2015 Resveratrol could reverse these effects, thereby increasing the expression of SIRT1 (0.87 +- 0.07 vs 0.54 +- 0.04), Coll2alpha1 (0.90 +- 0.08 vs 0.38 +- 0.01), and aggrecan (0.69 +- 0.07 vs 0.42 +- 0.05) and decreasing the expression of MMP-1 (0.61 +- 0.03 vs 0.93 +- 0.08). Resveratrol 0-11 sirtuin 1 Homo sapiens 78-83 25833683-0 2015 Resveratrol Regulates the Quiescence-Like Induction of Activated Stellate Cells by Modulating the PPARgamma/SIRT1 Ratio. Resveratrol 0-11 sirtuin 1 Homo sapiens 108-113 25401496-0 2015 Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 35-61 25401496-6 2015 Zymography, reverse-transcriptase polymerase chain reaction (PCR), and promoter assays confirmed the inhibitory effects of resveratrol on matrix metalloproteinase-9 (MMP-9) expression in oral cancer cells. Resveratrol 123-134 matrix metallopeptidase 9 Homo sapiens 138-164 25401496-6 2015 Zymography, reverse-transcriptase polymerase chain reaction (PCR), and promoter assays confirmed the inhibitory effects of resveratrol on matrix metalloproteinase-9 (MMP-9) expression in oral cancer cells. Resveratrol 123-134 matrix metallopeptidase 9 Homo sapiens 166-171 25401496-8 2015 Zymography and Western blot analyses suggested that resveratrol inhibited TPA-induced MMP-9 gelatinolytic activity and protein expression. Resveratrol 52-63 matrix metallopeptidase 9 Homo sapiens 86-91 25401496-9 2015 In addition, the results indicated that resveratrol inhibited the phosphorylation of c-Jun N-terminal kinase (JNK)1/2 and extracellular-signal-regulated kinase (ERK)1/2 involved in downregulating protein expression and the transcription of MMP-9. Resveratrol 40-51 matrix metallopeptidase 9 Homo sapiens 240-245 25401496-10 2015 CONCLUSION: In summary, resveratrol inhibited MMP-9 expression and oral cancer cell metastasis by downregulating JNK1/2 and ERK1/2 signals pathways and, thus, exerts beneficial effects in chemoprevention. Resveratrol 24-35 matrix metallopeptidase 9 Homo sapiens 46-51 26491826-0 2015 [Preliminary data on the effectiveness of resveratrol in a new formulation in treatment of hot flushes]. Resveratrol 42-53 alcohol dehydrogenase iron containing 1 Homo sapiens 91-94 26491826-1 2015 AIM: We conducted a pilot study to evaluate the effectiveness of resveratrol absorbed orally, conveyed through a new patented technology that increases the absorption through the oral mucosa in treatment of hot flushes (HF) during menopause. Resveratrol 65-76 alcohol dehydrogenase iron containing 1 Homo sapiens 207-210 26384348-10 2015 In vitro, the inhibitory effects of resveratrol on AII/AT1/NADPH-oxidase activity were confirmed in primary mesencephalic cultures, the N9 microglial cell line, and the dopaminergic neuron cell line MES 23.5, and they were blocked by the SIRT1 specific inhibitor EX527. Resveratrol 36-47 arginase type II Mus musculus 51-54 26122960-9 2015 Drug combination of BCNU + Resveratrol decreased the cell survival and NECTIN-4 expressions in 5-FU-R cells and NECTIN-4-over-expressed cells. Resveratrol 27-38 nectin cell adhesion molecule 4 Homo sapiens 71-79 26122960-9 2015 Drug combination of BCNU + Resveratrol decreased the cell survival and NECTIN-4 expressions in 5-FU-R cells and NECTIN-4-over-expressed cells. Resveratrol 27-38 nectin cell adhesion molecule 4 Homo sapiens 112-120 26044349-0 2015 Resveratrol suppresses persistent airway inflammation and hyperresponsivess might partially via nerve growth factor in respiratory syncytial virus-infected mice. Resveratrol 0-11 nerve growth factor Mus musculus 96-115 26212257-0 2015 Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. Resveratrol 0-11 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 135-138 26212257-0 2015 Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. Resveratrol 0-11 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 139-143 26212257-0 2015 Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. Resveratrol 0-11 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 144-148 26212257-5 2015 Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells. Resveratrol 0-11 BCL2-associated X protein Mus musculus 64-67 26212257-5 2015 Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells. Resveratrol 0-11 poly (ADP-ribose) polymerase family, member 1 Mus musculus 123-127 26212257-5 2015 Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells. Resveratrol 0-11 caspase 3 Mus musculus 132-141 26212257-11 2015 Thus, our findings revealed resveratrol and curcumin synergistically caused apoptosis in cigarette smoke induced breast cancer cells through p2(Waf/Cip1) mediated inhibition of Hedgehog-Gli cascade. Resveratrol 28-39 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 148-152 26044505-0 2015 Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts. Resveratrol 0-11 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 39-54 26044505-3 2015 The present study aimed to investigate the effects of resveratrol on BMP-4-induced osteoprotegerin (OPG) synthesis in MC3T3-E1 cells. Resveratrol 54-65 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 83-98 26044505-3 2015 The present study aimed to investigate the effects of resveratrol on BMP-4-induced osteoprotegerin (OPG) synthesis in MC3T3-E1 cells. Resveratrol 54-65 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 100-103 26044505-4 2015 Resveratrol alone had no effect on OPG expression levels, but significantly enhanced BMP-4-induced OPG release. Resveratrol 0-11 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 99-102 26044505-5 2015 In addition, resveratrol markedly amplified the mRNA expression levels of BMP-4-induced OPG. Resveratrol 13-24 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 88-91 26044505-8 2015 Furthermore, SB203580 significantly reduced the resveratrol-induced amplification of BMP-4-stimulated OPG release. Resveratrol 48-59 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 102-105 26044505-9 2015 These results suggested that resveratrol was able to upregulate BMP-4-stimulated OPG synthesis via the amplification of p38 MAP kinase activity in osteoblasts. Resveratrol 29-40 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 81-84 25967595-3 2015 In VSMCs stimulated with resveratrol, SIRT1 activator, PAF receptor (PAFR) was internalized and then its protein levels were diminished. Resveratrol 25-36 platelet-activating factor receptor Mus musculus 55-67 25967595-3 2015 In VSMCs stimulated with resveratrol, SIRT1 activator, PAF receptor (PAFR) was internalized and then its protein levels were diminished. Resveratrol 25-36 platelet-activating factor receptor Mus musculus 69-73 25967595-6 2015 In cells treated with nicotinamide, SIRT1 deacetylase inhibitor, PAFR internalization by resveratrol or reSIRT1 was inhibited, demonstrating that deacetylation of SIRT1 is an important step in SIRT1-induced PAFR down-regulation. Resveratrol 89-100 platelet-activating factor receptor Mus musculus 65-69 25967595-6 2015 In cells treated with nicotinamide, SIRT1 deacetylase inhibitor, PAFR internalization by resveratrol or reSIRT1 was inhibited, demonstrating that deacetylation of SIRT1 is an important step in SIRT1-induced PAFR down-regulation. Resveratrol 89-100 platelet-activating factor receptor Mus musculus 207-211 25967595-7 2015 Moreover, PAF-induced MMP-2 production in VSMCs and aorta was attenuated by resveratrol. Resveratrol 76-87 patchy fur Mus musculus 10-13 25967595-7 2015 Moreover, PAF-induced MMP-2 production in VSMCs and aorta was attenuated by resveratrol. Resveratrol 76-87 matrix metallopeptidase 2 Mus musculus 22-27 26348076-7 2015 Administration of resveratrol increased anti-oxidants, sucrose intake, weight gain, serotonin, StAR and cytochrome P450scc gene expression, testosterone, sperm count and motility, and decreased malondialdehyde and corticosterone in stressed rats with or without fluoxetine. Resveratrol 18-29 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 104-122 26063426-8 2015 Treatment of cells with resveratrol shunted Tax activity in a SIRT1-dependent manner. Resveratrol 24-35 sirtuin 1 Homo sapiens 62-67 26063426-9 2015 The activation of SIRT1 in HTLV-1-transformed T cells by resveratrol potently inhibited HTLV-1 proviral transcription and Tax expression, whereas compromising SIRT1 by specific inhibitors augmented HTLV-1 mRNA expression. Resveratrol 57-68 sirtuin 1 Homo sapiens 18-23 26063426-12 2015 Treatment with resveratrol prevented the interaction of Tax with CREB and the recruitment of CREB, CRTC1, and p300 to Tax-responsive elements in the LTR. Resveratrol 15-26 cAMP responsive element binding protein 1 Homo sapiens 65-69 26063426-12 2015 Treatment with resveratrol prevented the interaction of Tax with CREB and the recruitment of CREB, CRTC1, and p300 to Tax-responsive elements in the LTR. Resveratrol 15-26 cAMP responsive element binding protein 1 Homo sapiens 93-97 26063426-14 2015 Small-molecule activators of SIRT1 such as resveratrol might be considered new prophylactic and therapeutic agents in HTLV-1-associated diseases. Resveratrol 43-54 sirtuin 1 Homo sapiens 29-34 25808216-2 2015 Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral insulin sensitivity of these mice. Resveratrol 54-65 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 0-31 25808216-2 2015 Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral insulin sensitivity of these mice. Resveratrol 54-65 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 33-38 25808216-8 2015 Interestingly, resveratrol decreased PTP1B in both tissues, thereby restoring IRS1-mediated insulin signaling. Resveratrol 15-26 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 37-42 25808216-11 2015 CONCLUSION: Resveratrol improves peripheral insulin signaling independently of Sirt1 in diabetic mice in association with the inhibition of PTP1B and, therefore, this polyphenol could be an effective adjuvant for the treatment of diabetes. Resveratrol 12-23 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 140-145 25936796-3 2015 Co-treatment using resveratrol and 5-FU inhibited cell proliferation more efficiently compared with use of either drug alone and the antiproliferative effect coincided with changes in the expression levels of AMP-activated protein kinase (AMPK), cyclooxygenase-2, vasodilator-stimulated phosphoprotein (VASP) and vascular endothelial growth factor (VEGF). Resveratrol 19-30 vascular endothelial growth factor A Mus musculus 313-347 25936796-3 2015 Co-treatment using resveratrol and 5-FU inhibited cell proliferation more efficiently compared with use of either drug alone and the antiproliferative effect coincided with changes in the expression levels of AMP-activated protein kinase (AMPK), cyclooxygenase-2, vasodilator-stimulated phosphoprotein (VASP) and vascular endothelial growth factor (VEGF). Resveratrol 19-30 vascular endothelial growth factor A Mus musculus 349-353 25936796-4 2015 Furthermore, co-treatment with resveratrol and 5-FU reduced tumor growth compared with that in the control group and this growth-inhibitory effect was associated with changes in the expression levels of AMPK, VASP and VEGF. Resveratrol 31-42 vascular endothelial growth factor A Mus musculus 218-222 25943029-6 2015 Moreover, RSV increased cAMP levels and the levels of SIRT1 (sirtuin 1), pPRKA (phosphorylated protein kinase A), and pAMPK (phosphorylated AMP-activated protein kinase), as well as SIRT1 activity in HepG2 cells. Resveratrol 10-13 sirtuin 1 Homo sapiens 54-59 25943029-6 2015 Moreover, RSV increased cAMP levels and the levels of SIRT1 (sirtuin 1), pPRKA (phosphorylated protein kinase A), and pAMPK (phosphorylated AMP-activated protein kinase), as well as SIRT1 activity in HepG2 cells. Resveratrol 10-13 sirtuin 1 Homo sapiens 61-70 25943029-6 2015 Moreover, RSV increased cAMP levels and the levels of SIRT1 (sirtuin 1), pPRKA (phosphorylated protein kinase A), and pAMPK (phosphorylated AMP-activated protein kinase), as well as SIRT1 activity in HepG2 cells. Resveratrol 10-13 sirtuin 1 Homo sapiens 182-187 25943029-7 2015 Incubation with inhibitors of AC (adenylyl cyclase), PRKA, AMPK, SIRT1, or with AC, PRKA, AMPK, or SIRT1 siRNA abolished RSV-mediated autophagy. Resveratrol 121-124 sirtuin 1 Homo sapiens 65-70 25943029-7 2015 Incubation with inhibitors of AC (adenylyl cyclase), PRKA, AMPK, SIRT1, or with AC, PRKA, AMPK, or SIRT1 siRNA abolished RSV-mediated autophagy. Resveratrol 121-124 sirtuin 1 Homo sapiens 99-104 25943029-9 2015 CONCLUSION: RSV improved hepatic steatosis partially by inducing autophagy via the cAMP-PRKA-AMPK-SIRT1 signaling pathway, which provides new evidence regarding RSV"s effects on NAFLD treatment. Resveratrol 12-15 sirtuin 1 Homo sapiens 98-103 25943029-9 2015 CONCLUSION: RSV improved hepatic steatosis partially by inducing autophagy via the cAMP-PRKA-AMPK-SIRT1 signaling pathway, which provides new evidence regarding RSV"s effects on NAFLD treatment. Resveratrol 161-164 sirtuin 1 Homo sapiens 98-103 26955731-11 2015 Ang II significantly decreased MnSOD expression of cardiomyocytes compared with control group (P < 0.05), which was reversed by RSV (25 micromol/L). Resveratrol 131-134 superoxide dismutase 2 Rattus norvegicus 31-36 25815440-0 2015 Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells. Resveratrol 0-11 C-X-C motif chemokine receptor 4 Homo sapiens 86-110 25819224-5 2015 Resveratrol supported significantly higher cleavage and blastocyst formation rates than the control (80.3% and 38.0% vs. 71.1% and 22.4%, respectively) by downregulating Bax/Bcl-2, Caspase-3, and Bak. Resveratrol 0-11 BCL2 antagonist/killer 1 Homo sapiens 196-199 26046330-3 2015 We previously showed that resveratrol, an antioxidant and an activator of the protein deacetylase Sirt1, enhanced hematopoiesis in Fancd2 mutant mice and improved the impaired stem cell quiescence observed in this disease. Resveratrol 26-37 Fanconi anemia, complementation group D2 Mus musculus 131-137 26454959-8 2015 However, the resveratrol 40, 80 mg/kg and estradiol valerate treated groups showed a decrease in the expression of GFAP compared with the model group (P < 0.01). Resveratrol 13-24 glial fibrillary acidic protein Rattus norvegicus 115-119 26454959-9 2015 Moreover, with the increasing of resveratrol concentration, the expression of GFAP decreased gradually. Resveratrol 33-44 glial fibrillary acidic protein Rattus norvegicus 78-82 24998844-0 2015 Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Resveratrol 0-11 G3BP stress granule assembly factor 1 Homo sapiens 52-110 24998844-3 2015 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of resveratrol, and in vitro binding assay results using resveratrol-conjugated Sepharose 4B beads confirmed their direct binding. Resveratrol 117-128 G3BP stress granule assembly factor 1 Homo sapiens 10-68 24998844-3 2015 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of resveratrol, and in vitro binding assay results using resveratrol-conjugated Sepharose 4B beads confirmed their direct binding. Resveratrol 117-128 G3BP stress granule assembly factor 1 Homo sapiens 70-75 24998844-3 2015 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of resveratrol, and in vitro binding assay results using resveratrol-conjugated Sepharose 4B beads confirmed their direct binding. Resveratrol 171-182 G3BP stress granule assembly factor 1 Homo sapiens 10-68 24998844-3 2015 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of resveratrol, and in vitro binding assay results using resveratrol-conjugated Sepharose 4B beads confirmed their direct binding. Resveratrol 171-182 G3BP stress granule assembly factor 1 Homo sapiens 70-75 24998844-4 2015 Depletion of G3BP1 significantly diminishes resveratrol-induced p53 expression and apoptosis. Resveratrol 44-55 G3BP stress granule assembly factor 1 Homo sapiens 13-18 24998844-7 2015 Resveratrol, on the other hand, directly binds to G3BP1 and prevents the G3BP1/USP10 interaction, resulting in enhanced USP10-mediated deubiquitination of p53, and consequently increased p53 expression. Resveratrol 0-11 G3BP stress granule assembly factor 1 Homo sapiens 50-55 24998844-7 2015 Resveratrol, on the other hand, directly binds to G3BP1 and prevents the G3BP1/USP10 interaction, resulting in enhanced USP10-mediated deubiquitination of p53, and consequently increased p53 expression. Resveratrol 0-11 G3BP stress granule assembly factor 1 Homo sapiens 73-78 24998844-8 2015 These findings disclose a novel mechanism of resveratrol-induced p53 activation and resveratrol-induced apoptosis by direct targeting of G3BP1. Resveratrol 45-56 G3BP stress granule assembly factor 1 Homo sapiens 137-142 24998844-8 2015 These findings disclose a novel mechanism of resveratrol-induced p53 activation and resveratrol-induced apoptosis by direct targeting of G3BP1. Resveratrol 84-95 G3BP stress granule assembly factor 1 Homo sapiens 137-142 25965695-3 2015 The Sirtuin1 enzyme thought to mediate the effects of resveratrol is present in skin and resveratrol is known to down regulate NF-kappaB; an important contributor in the development of psoriasis. Resveratrol 89-100 sirtuin 1 Homo sapiens 4-12 25965695-11 2015 The RNA microarray revealed a psoriasis-like gene expression-profile in the Imiquimod treated group, and highlighted several resveratrol dependent changes in relevant genes, such as increased expression of genes associated with retinoic acid stimulation and reduced expression of genes involved in IL-17 dependent pathways. Resveratrol 125-136 interleukin 17A Homo sapiens 298-303 25965695-12 2015 Quantitative PCR confirmed a resveratrol dependent decrease in mRNA levels of IL-17A and IL-19; both central in developing psoriasis. Resveratrol 29-40 interleukin 17A Homo sapiens 78-84 25965695-12 2015 Quantitative PCR confirmed a resveratrol dependent decrease in mRNA levels of IL-17A and IL-19; both central in developing psoriasis. Resveratrol 29-40 interleukin 19 Homo sapiens 89-94 25965695-13 2015 CONCLUSIONS: Resveratrol ameliorates psoriasis, and changes expression of retinoic acid stimulated genes, IL-17 signalling pathways, IL-17A and IL-19 mRNA levels in a beneficial manner, which suggests resveratrol, might have a role in the treatment of psoriasis and should be explored further in a human setting. Resveratrol 13-24 interleukin 17A Homo sapiens 106-111 25965695-13 2015 CONCLUSIONS: Resveratrol ameliorates psoriasis, and changes expression of retinoic acid stimulated genes, IL-17 signalling pathways, IL-17A and IL-19 mRNA levels in a beneficial manner, which suggests resveratrol, might have a role in the treatment of psoriasis and should be explored further in a human setting. Resveratrol 13-24 interleukin 17A Homo sapiens 133-139 25965695-13 2015 CONCLUSIONS: Resveratrol ameliorates psoriasis, and changes expression of retinoic acid stimulated genes, IL-17 signalling pathways, IL-17A and IL-19 mRNA levels in a beneficial manner, which suggests resveratrol, might have a role in the treatment of psoriasis and should be explored further in a human setting. Resveratrol 13-24 interleukin 19 Homo sapiens 144-149 25961718-0 2015 Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/beta-Catenin Is Protective in Vessel Graft Models. Resveratrol 0-11 catenin (cadherin associated protein), beta 1 Mus musculus 99-111 25961718-10 2015 Both the inhibition of miR-21 and the knockdown of beta-catenin were able to recapitulate the effect of resveratrol application. Resveratrol 104-115 catenin (cadherin associated protein), beta 1 Mus musculus 51-63 25961718-13 2015 CONCLUSIONS AND IMPLICATIONS: We provide the first evidence that oral administration of resveratrol can reduce neointimal formation in a model of vascular graft and elucidated the underpinning miR-21/Akt/beta-catenin dependent mechanism. Resveratrol 88-99 catenin (cadherin associated protein), beta 1 Mus musculus 204-216 25640634-0 2015 Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation. Resveratrol 0-11 nitric oxide synthase, endothelial Oryctolagus cuniculus 113-117 25640634-11 2015 PI3K, AKT, and eNOS messenger RNA and protein expression were upregulated by resveratrol but were inhibited by the coadministration of wortmannin and DPI. Resveratrol 77-88 nitric oxide synthase, endothelial Oryctolagus cuniculus 15-19 25640634-12 2015 CONCLUSION: Resveratrol decreases left atrial fibrosis and regulates variation in ion channels to reduce AF through the PI3K/AKT/eNOS signaling pathway. Resveratrol 12-23 nitric oxide synthase, endothelial Oryctolagus cuniculus 129-133 25666415-0 2015 Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters. Resveratrol 22-33 nicotinamide phosphoribosyltransferase Rattus norvegicus 99-107 25683371-7 2015 Moreover, small molecules embelin, LY294002 and resveratrol improved the cytotoxicity of ZD55-TRAIL. Resveratrol 48-59 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 94-99 25909427-10 2015 We further found that injured mice treated with a SIRT1 activator, resveratrol, showed significantly decreased polymorphonuclear leukocytes (PMN) in the BAL in response to intratracheal LPS and increased survival from CLP. Resveratrol 67-78 hyaluronan and proteoglycan link protein 1 Mus musculus 218-221 25909427-12 2015 Treatment of injured mice with a SIRT1 activator, resveratrol, decreased LPS inflammatory response and increased survival after CLP. Resveratrol 50-61 hyaluronan and proteoglycan link protein 1 Mus musculus 128-131 25220663-2 2014 We hypothesized that ethanol extract of Smilax china root (EESC) rich in resveratrol (RES) and oxyresveratrol (OXY) could reduce ROS caused by nicotine and promoting nicotine turnover by induction of CYP2A6. Resveratrol 73-84 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 200-206 25220663-2 2014 We hypothesized that ethanol extract of Smilax china root (EESC) rich in resveratrol (RES) and oxyresveratrol (OXY) could reduce ROS caused by nicotine and promoting nicotine turnover by induction of CYP2A6. Resveratrol 86-89 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 200-206 25149975-0 2014 The effect of resveratrol and its methylthio-derivatives on NF-kappaB and AP-1 signaling pathways in HaCaT keratinocytes. Resveratrol 14-25 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 74-78 25156660-2 2014 The effects of resveratrol (trans-3,5,4"-trihydroxystilbene) that can protect T lymphocytes in various disease conditions on the HFD-induced apoptosis of CD4(+) CD25(+) CD127(low/-) regulatory T cells (Tregs) were studied, and the possible mechanism was postulated. Resveratrol 15-26 CD4 antigen Mus musculus 154-157 25156660-2 2014 The effects of resveratrol (trans-3,5,4"-trihydroxystilbene) that can protect T lymphocytes in various disease conditions on the HFD-induced apoptosis of CD4(+) CD25(+) CD127(low/-) regulatory T cells (Tregs) were studied, and the possible mechanism was postulated. Resveratrol 15-26 interleukin 2 receptor, alpha chain Mus musculus 161-165 24813642-0 2014 Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. Resveratrol 15-26 prostaglandin D2 synthase (brain) Mus musculus 30-46 24582596-6 2014 We show that resveratrol regulates energy homeostasis through activation of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) and raise of mRNA expression of a number of PGC-1alpha"s target genes resulting in enhanced mitochondrial oxidative function, likely related to a decrease of oxidative stress and to an increase of mitochondrial biogenesis. Resveratrol 13-24 sirtuin 1 Homo sapiens 116-125 24582596-6 2014 We show that resveratrol regulates energy homeostasis through activation of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) and raise of mRNA expression of a number of PGC-1alpha"s target genes resulting in enhanced mitochondrial oxidative function, likely related to a decrease of oxidative stress and to an increase of mitochondrial biogenesis. Resveratrol 13-24 sirtuin 1 Homo sapiens 127-132 24582596-8 2014 Moreover, resveratrol treatment caused an enhanced macro-autophagic flux through activation of an LC3-independent pathway. Resveratrol 10-21 microtubule associated protein 1 light chain 3 alpha Homo sapiens 98-101 24753227-0 2014 Resveratrol stimulates AP-1-regulated gene transcription. Resveratrol 0-11 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 23-27 24753227-2 2014 Here, we have analyzed the impact of resveratrol on the activity of the transcription factor activator protein-1 (AP-1). Resveratrol 37-48 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 93-112 24753227-2 2014 Here, we have analyzed the impact of resveratrol on the activity of the transcription factor activator protein-1 (AP-1). Resveratrol 37-48 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 114-118 24753227-3 2014 METHODS AND RESULTS: Using a chromosomally embedded AP-1-responsive reporter gene, we show that the AP-1 activity was significantly elevated in resveratrol-treated 293 human embryonic kidney and HepG2 hepatoma cells. Resveratrol 144-155 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 52-56 24753227-3 2014 METHODS AND RESULTS: Using a chromosomally embedded AP-1-responsive reporter gene, we show that the AP-1 activity was significantly elevated in resveratrol-treated 293 human embryonic kidney and HepG2 hepatoma cells. Resveratrol 144-155 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 100-104 24753227-4 2014 The 12-O-tetradecanoylphorbol-13-acetate-responsive element, a binding site for c-Jun and c-Fos, was identified as resveratrol-responsive element. Resveratrol 115-126 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 80-85 24753227-4 2014 The 12-O-tetradecanoylphorbol-13-acetate-responsive element, a binding site for c-Jun and c-Fos, was identified as resveratrol-responsive element. Resveratrol 115-126 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 90-95 24753227-5 2014 Expression of c-Jun and c-Fos, two proteins that constitute AP-1, is upregulated in resveratrol-stimulated HEK293 cells. Resveratrol 84-95 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 14-19 24753227-5 2014 Expression of c-Jun and c-Fos, two proteins that constitute AP-1, is upregulated in resveratrol-stimulated HEK293 cells. Resveratrol 84-95 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 24-29 24753227-5 2014 Expression of c-Jun and c-Fos, two proteins that constitute AP-1, is upregulated in resveratrol-stimulated HEK293 cells. Resveratrol 84-95 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 60-64 24753227-6 2014 On the transcriptional level, c-Jun and the ternary complex factor Elk-1 are essential for the activation of AP-1 in resveratrol-treated cells. Resveratrol 117-128 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 30-35 24753227-6 2014 On the transcriptional level, c-Jun and the ternary complex factor Elk-1 are essential for the activation of AP-1 in resveratrol-treated cells. Resveratrol 117-128 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 109-113 24753227-7 2014 In addition, mitogen-activated protein kinases and protein kinase C are required to connect resveratrol stimulation with enhanced AP-1 controlled transcription. Resveratrol 92-103 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 130-134 24753227-8 2014 Finally, we show that resveratrol increased the activities of the AP-1 responsive cyclin D1 and tumor necrosis factor alpha promoters. Resveratrol 22-33 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 66-70 24753227-9 2014 CONCLUSION: Resveratrol regulates gene transcription via activation of stimulus-regulated protein kinases and the stimulus-responsive AP-1 transcription factors. Resveratrol 12-23 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-138 24753227-10 2014 The fact that resveratrol regulates AP-1 activity may explain many of the pleiotropic intracellular alterations induced by resveratrol. Resveratrol 14-25 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 36-40 24753227-10 2014 The fact that resveratrol regulates AP-1 activity may explain many of the pleiotropic intracellular alterations induced by resveratrol. Resveratrol 123-134 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 36-40 24818579-0 2014 Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway. Resveratrol 21-32 myeloid differentiation primary response gene 88 Mus musculus 108-113 24818579-3 2014 The present study investigated whether the protective effect of resveratrol on ALI induced by LPS was via inhibiting the myeloid differentiation primary response gene (myd88)-dependent toll-like receptor (TLR)4 signaling pathway. Resveratrol 64-75 myeloid differentiation primary response gene 88 Mus musculus 168-173 24818579-9 2014 Additionally, resveratrol markedly decreased the expression of TLR4, myd88 and NF-kappaB and decreased the concentration of inflammatory cytokines, including IL-6 and COX-2. Resveratrol 14-25 myeloid differentiation primary response gene 88 Mus musculus 69-74 24818579-10 2014 Therefore, it can be concluded that resveratrol has a protective effect against ALI induced by LPS, at least in part by inhibiting the myd88-dependent TLR4 signaling pathway. Resveratrol 36-47 myeloid differentiation primary response gene 88 Mus musculus 135-140 24841706-7 2014 Treatment with SP600125, a JNK inhibitor, attenuated the effects of resveratrol on MMP-2 and MMP-9, and accelerated resveratrol-induced effects on type II collagen, SOX-9 and sulfated proteoglycan production. Resveratrol 68-79 matrix metallopeptidase 9 Homo sapiens 93-98 24639483-10 2014 In contrast, resveratrol restored SIRT1 activity and suppressed elevations of Foxo1 acetylation, Bim and pro-apoptotic signalling in the aged heart. Resveratrol 13-24 BCL2-like 11 (apoptosis facilitator) Mus musculus 97-100 24639483-12 2014 In conclusion, these novel data demonstrate that resveratrol mitigates pro-apoptotic signalling in senescent heart through a deacetylation mechanism of SIRT1 that represses the Foxo1-Bim-associated pro-apoptotic signalling axis. Resveratrol 49-60 BCL2-like 11 (apoptosis facilitator) Mus musculus 183-186 24547812-9 2014 Treatment with the AMPK activator resveratrol decreased levels of NADPH oxidase subunits and ROS, and increased NO and SOD2 levels in the NTS of fructose-fed rats. Resveratrol 34-45 superoxide dismutase 2 Rattus norvegicus 119-123 24547812-11 2014 CONCLUSIONS AND IMPLICATIONS: Collectively, resveratrol decreased BP through the phosphorylation of AMPK, Akt and neuronal NOS in fructose-fed rats. Resveratrol 44-55 nitric oxide synthase 1 Rattus norvegicus 114-126 24675227-11 2014 Treatment with the ALDH2 activator Alda-1 accentuated aging-induced O2(-) generation and mechanical dysfunction in cardiomyocytes, the effects of which were mitigated by cotreatment with activators of AMPK and Sirt1, AICAR, resveratrol, and SRT1720. Resveratrol 224-235 sirtuin 1 Homo sapiens 210-215 24722352-10 2014 Resveratrol significantly decreases mRNA expression of Lpl, Scd1, Ppar-gamma, Acc1, and Fas related to fatty acids synthesis, adipogenesis and lipogenesis, which may be driven by increased Fiaf expression. Resveratrol 0-11 lipoprotein lipase Mus musculus 55-58 24722352-10 2014 Resveratrol significantly decreases mRNA expression of Lpl, Scd1, Ppar-gamma, Acc1, and Fas related to fatty acids synthesis, adipogenesis and lipogenesis, which may be driven by increased Fiaf expression. Resveratrol 0-11 stearoyl-Coenzyme A desaturase 1 Mus musculus 60-64 24682241-11 2014 OGD induced cell apoptosis, the expression of Bax and the activation of caspase-3 and ERK, inhibited the expression of Bcl-2 and increased the expression of MMP-9, while these effects were reversed by treatment with resveratrol. Resveratrol 216-227 BCL2-associated X protein Mus musculus 46-49 24682241-11 2014 OGD induced cell apoptosis, the expression of Bax and the activation of caspase-3 and ERK, inhibited the expression of Bcl-2 and increased the expression of MMP-9, while these effects were reversed by treatment with resveratrol. Resveratrol 216-227 caspase 3 Mus musculus 72-81 24604347-3 2014 Herein, we aimed to examine whether the anticancer effect of RSV was related to the VEGF-B. Resveratrol 61-64 vascular endothelial growth factor B Homo sapiens 84-90 24604347-8 2014 The mRNA and protein levels of VEGF-B were up-regulated after RSV treatment. Resveratrol 62-65 vascular endothelial growth factor B Homo sapiens 31-37 24464877-7 2014 After resveratrol induction, MSCs acquire neuronal-like cell morphologies and phenotypes, Smo translocates to the primary cilia, Gli1 enters the nucleus, and expressions of Smo and Gli1 proteins increase, which can be inhibited by cyclopamine, a Smo antagonist. Resveratrol 6-17 GLI family zinc finger 1 Homo sapiens 129-133 24464877-7 2014 After resveratrol induction, MSCs acquire neuronal-like cell morphologies and phenotypes, Smo translocates to the primary cilia, Gli1 enters the nucleus, and expressions of Smo and Gli1 proteins increase, which can be inhibited by cyclopamine, a Smo antagonist. Resveratrol 6-17 GLI family zinc finger 1 Homo sapiens 181-185 24799987-3 2014 An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1). Resveratrol 51-62 sirtuin 1 Homo sapiens 142-183 24799987-3 2014 An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1). Resveratrol 51-62 sirtuin 1 Homo sapiens 185-190 24799987-3 2014 An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1). Resveratrol 64-67 sirtuin 1 Homo sapiens 142-183 24799987-3 2014 An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1). Resveratrol 64-67 sirtuin 1 Homo sapiens 185-190 24390595-1 2014 The aim of the present study was to address the effect of resveratrol-mediated upregulation of sirtuin 1 (SIRT1) during oocyte maturation on mitochondrial function, the developmental ability of oocytes and on mechanisms responsible for blockage of polyspermic fertilization. Resveratrol 58-69 sirtuin 1 Bos taurus 95-104 24390595-1 2014 The aim of the present study was to address the effect of resveratrol-mediated upregulation of sirtuin 1 (SIRT1) during oocyte maturation on mitochondrial function, the developmental ability of oocytes and on mechanisms responsible for blockage of polyspermic fertilization. Resveratrol 58-69 sirtuin 1 Bos taurus 106-111 24747689-1 2014 The present study assessed the effect of resveratrol on the expression of SIRT1 and mitochondrial quality and quantity in porcine oocytes. Resveratrol 41-52 sirtuin 1 Homo sapiens 74-79 24747689-2 2014 Supplementing the maturation medium with 20 microM resveratrol increased the expression of SIRT1, and enhanced mitochondrial functions, as observed from the increased ATP content and mitochondrial membrane potential. Resveratrol 51-62 sirtuin 1 Homo sapiens 91-96 24747689-7 2014 In addition, when resveratrol was added to the medium containing MG132, the Mt number increased significantly by 39%, this effect was diminished by the addition of the SIRT1 inhibitor EX527. Resveratrol 18-29 sirtuin 1 Homo sapiens 168-173 24747689-11 2014 In addition, activation of SIRT1 by resveratrol enhances the biosynthesis and degradation of mitochondria in oocytes, thereby replenishing and improving mitochondrial function and the developmental ability of oocytes. Resveratrol 36-47 sirtuin 1 Homo sapiens 27-32 24694235-10 2014 Resveratrol protected brain neurons against high-fat diet-induced caspase-3 activation and genomic DNA fragmentation. Resveratrol 0-11 caspase 3 Mus musculus 66-75 24498857-0 2014 Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2). Resveratrol 0-11 solute carrier family 10 member 2 Homo sapiens 68-72 24498857-0 2014 Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2). Resveratrol 0-11 solute carrier family 10 member 2 Homo sapiens 74-81 24498857-4 2014 In the present study, we investigated the possible involvement of ASBT in RSV-mediated cholesterol-lowering effects. Resveratrol 74-77 solute carrier family 10 member 2 Homo sapiens 66-70 24498857-5 2014 We demonstrate that RSV inhibits ASBT protein expression and function via a SIRT1 (sirtuin 1)-independent mechanism. Resveratrol 20-23 solute carrier family 10 member 2 Homo sapiens 33-37 24498857-5 2014 We demonstrate that RSV inhibits ASBT protein expression and function via a SIRT1 (sirtuin 1)-independent mechanism. Resveratrol 20-23 sirtuin 1 Homo sapiens 76-81 24498857-5 2014 We demonstrate that RSV inhibits ASBT protein expression and function via a SIRT1 (sirtuin 1)-independent mechanism. Resveratrol 20-23 sirtuin 1 Homo sapiens 83-92 24498857-7 2014 ASBT inhibition by RSV was reversed by proteasome inhibitors (MG-132 and lactacystin) and the ubiquitin inhibitor LDN57444, suggesting involvement of the ubiquitin-proteasome pathway. Resveratrol 19-22 solute carrier family 10 member 2 Homo sapiens 0-4 24498857-8 2014 Immunoprecipitation revealed high levels of ubiquitinated ASBT after RSV treatment. Resveratrol 69-72 solute carrier family 10 member 2 Homo sapiens 58-62 24498857-11 2014 Combined, our data indicate that RSV promotes ASBT degradation via the ubiquitin-proteasome pathway without requiring phosphorylation. Resveratrol 33-36 solute carrier family 10 member 2 Homo sapiens 46-50 24498857-12 2014 We conclude that regulation of ASBT expression by RSV may have clinical relevance with regard to the observed cholesterol-lowering effects of RSV. Resveratrol 50-53 solute carrier family 10 member 2 Homo sapiens 31-35 24498857-12 2014 We conclude that regulation of ASBT expression by RSV may have clinical relevance with regard to the observed cholesterol-lowering effects of RSV. Resveratrol 142-145 solute carrier family 10 member 2 Homo sapiens 31-35 24722566-0 2014 Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. Resveratrol 42-53 sirtuin 1 Homo sapiens 83-88 24722566-4 2014 As a polyphenolic compound, resveratrol is frequently used as an activator of Sirt1 (Sirtuin 1). Resveratrol 28-39 sirtuin 1 Homo sapiens 78-83 24722566-4 2014 As a polyphenolic compound, resveratrol is frequently used as an activator of Sirt1 (Sirtuin 1). Resveratrol 28-39 sirtuin 1 Homo sapiens 85-94 24722566-5 2014 The present study was designed to explore the radioprotective and antioxidant effect of resveratrol on Sirt1 expression and activity induced by radiation and to provide a new target for the development of radiation protection drugs. Resveratrol 88-99 sirtuin 1 Homo sapiens 103-108 24722566-6 2014 Our results demonstrate that resveratrol inhibits apoptosis induced by radiation via the activation of Sirt1. Resveratrol 29-40 sirtuin 1 Homo sapiens 103-108 24722566-7 2014 We demonstrated an increase in Sirt1 mRNA that was present on 21 days of resveratrol treatment following irradiation in a concentration-dependent manner. Resveratrol 73-84 sirtuin 1 Homo sapiens 31-36 24705375-10 2014 However, the enzyme activities of caspase 3 and caspase 9 showed a significant increase upon treatment with curcumin and resveratrol. Resveratrol 121-132 caspase 3 Mus musculus 34-43 24423486-0 2014 Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke. Resveratrol 0-11 scavenger receptor class B member 1 Homo sapiens 21-26 24423486-7 2014 In this study, we demonstrate that resveratrol at doses ranging from 0.5 to 10 muM is not toxic and is able to increase SR-B1 protein levels in a dose-dependent manner in human keratinocytes. Resveratrol 35-46 scavenger receptor class B member 1 Homo sapiens 120-125 24423486-8 2014 Moreover, when the cells that were pretreated with various doses of resveratrol were exposed to CS, the loss of SR-B1 was prevented in a dose-dependent manner. Resveratrol 68-79 scavenger receptor class B member 1 Homo sapiens 112-117 24423486-10 2014 In particular resveratrol was able to prevent HNE-SR-B1 adduct formation. Resveratrol 14-25 scavenger receptor class B member 1 Homo sapiens 50-55 24423486-11 2014 Thus, resveratrol seems to be a natural compound that could provide skin with a defense against exogenous stressors by protecting the essential cholesterol receptor, SR-B1. Resveratrol 6-17 scavenger receptor class B member 1 Homo sapiens 166-171 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 28-39 suppressor of cytokine signaling 1 Mus musculus 85-119 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 28-39 suppressor of cytokine signaling 1 Mus musculus 121-127 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 28-39 suppressor of cytokine signaling 1 Mus musculus 291-297 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 161-172 suppressor of cytokine signaling 1 Mus musculus 85-119 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 161-172 suppressor of cytokine signaling 1 Mus musculus 121-127 23764428-5 2014 Consistent with these data, resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resveratrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS-1 induction. Resveratrol 161-172 suppressor of cytokine signaling 1 Mus musculus 291-297 24435444-0 2014 Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase. Resveratrol 0-11 vascular endothelial growth factor A Mus musculus 38-42 24435444-3 2014 In the present study, we investigated the effect of resveratrol on the BMP-4-stimulated VEGF synthesis in MC3T3-E1 cells. Resveratrol 52-63 vascular endothelial growth factor A Mus musculus 88-92 24518759-8 2014 Transient SIRT1 overexpression or chemical induction by resveratrol treatment reverses senescence phenotype, and rescues in vitro PT-ECFC angiogenic defect in a SIRT1-dependent manner. Resveratrol 56-67 sirtuin 1 Homo sapiens 161-166 24433070-4 2014 Resveratrol significantly decreased the plasma total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) concentrations, apoB/apoA-I ratio, hepatic cholesterol, and triglyceride (TG) contents, whereas significantly it increased the plasma HDL-C concentration compared with the control and lovastatin groups. Resveratrol 0-11 apolipoprotein A-I Mus musculus 195-201 24320086-0 2014 Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway. Resveratrol 0-11 sirtuin 1 Homo sapiens 126-135 24039193-6 2014 Inhibition of resveratrol targets sirtuin-1, cyclic AMP production and the c-Jun N-terminal, phosphoinositide 3 and AMP-activated kinases did not block induction of CAMP by resveratrol or synergy with 1alpha,25(OH)2 D3. Resveratrol 14-25 sirtuin 1 Homo sapiens 34-43 24439680-6 2014 The fact that two-thirds of people in the USA who consume multiple dietary supplements consume resveratrol, a SIRT1 activator, underscores the importance of understanding the biochemical mechanism, physiological effects, and safety of STACs. Resveratrol 95-106 sirtuin 1 Homo sapiens 110-115 24587049-7 2014 The results revealed that 2 h 150 microM or 200 microM resveratrol treatment leaded to remarkable S phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of STAT3, down-regulation of STAT3 downstream genes (survivin, cyclinD1, c-Myc and VEGF) and nuclear translocations of Sirt1 and p53. Resveratrol 55-66 cyclin D1 Mus musculus 295-303 24587049-7 2014 The results revealed that 2 h 150 microM or 200 microM resveratrol treatment leaded to remarkable S phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of STAT3, down-regulation of STAT3 downstream genes (survivin, cyclinD1, c-Myc and VEGF) and nuclear translocations of Sirt1 and p53. Resveratrol 55-66 vascular endothelial growth factor A Mus musculus 315-319 24551237-3 2014 Here we show that leucine exerts a direct effect on Sirt1 kinetics, reducing its Km for NAD(+) by >50% and enabling low doses of resveratrol to further activate the enzyme (p = 0.012). Resveratrol 132-143 sirtuin 1 Homo sapiens 52-57 23975182-0 2014 Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Resveratrol 0-11 forkhead box O3 Mus musculus 62-67 23975182-8 2014 These data indicate that resveratrol inhibits Akt resulting in FoxO3 activation with upregulation of cytoprotective systems enabling the pathological erythroid precursors to resist the oxidative damage and continue to differentiate. Resveratrol 25-36 forkhead box O3 Mus musculus 63-68 23975182-9 2014 Our data suggest that the dual effect of resveratrol on erythropoiesis through activation of FoxO3 transcriptional factor combined with the amelioration of oxidative stress in circulating red cells may be considered as a potential novel therapeutic strategy in treating beta-thalassemia. Resveratrol 41-52 forkhead box O3 Mus musculus 93-98 23918588-0 2014 Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. Resveratrol 11-22 sirtuin 1 Homo sapiens 84-89 23918588-1 2014 OBJECTIVES: The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression and energy expenditure in subjects with Type 2 diabetes mellitus (T2DM). Resveratrol 72-83 sirtuin 1 Homo sapiens 103-108 23918588-2 2014 BACKGROUND: Animal and in vivo studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1alpha activity. Resveratrol 53-64 sirtuin 1 Homo sapiens 75-80 23918588-8 2014 CONCLUSIONS: In patients with T2DM, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. Resveratrol 51-62 sirtuin 1 Homo sapiens 126-131 24254769-6 2014 Moreover, decreased expression of SIRT1 and its activity by Abeta were significantly reversed by cilostazol as by resveratrol. Resveratrol 114-125 sirtuin 1 Homo sapiens 34-39 23255428-7 2014 Two proteins, actin and Hsp60, were previously shown in other cell culture systems to be affected by resveratrol, validating our approach. Resveratrol 101-112 heat shock protein family D (Hsp60) member 1 Homo sapiens 24-29 24454277-5 2014 Resveratrol, a SIRT1 activator reduced hyperglycemia likely through activation of vagal output; however, the cellular mechanisms of action have not been determined. Resveratrol 0-11 sirtuin 1 Homo sapiens 15-20 24454277-6 2014 In this study, whole-cell patch-clamp electrophysiology on acute brainstem slices was used to test the hypothesis that activation of SIRT1 with resveratrol enhances neurotransmission in DMV neurons. Resveratrol 144-155 sirtuin 1 Homo sapiens 133-138 24454277-11 2014 In conclusion, our data demonstrate that resveratrol via SIRT1 increases excitatory neurotransmission to DMV neurons. Resveratrol 41-52 sirtuin 1 Homo sapiens 57-62 24165878-7 2014 Therefore, the ability of resveratrol and epigallocatechin gallate to bind miR-33a and miR-122 was measured using (1)H NMR spectroscopy. Resveratrol 26-37 microRNA 122 Homo sapiens 87-94 24895526-4 2014 Resveratrol-pretreated human monocyte-derived M1 and M2 macrophages were challenged with 7-oxo-cholesterol and analyzed for phenotype and endocytic ability by flow cytometry, for metalloproteinase- (MMP-) 2 and MMP-9 by gelatin zymography, and for cytokine, chemokine, and growth factor secretome by a multiplex immunoassay. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 211-216 24895526-6 2014 In the M1 subset, resveratrol prevented the downregulation of CD16 and the upregulation of MMP-2 in response to 7-oxo-cholesterol, whereas in M2 macrophages it prevented the upregulation of CD14, MMP-2, and MMP-9 and the downregulation of endocytosis. Resveratrol 18-29 matrix metallopeptidase 9 Homo sapiens 207-212 25147862-5 2014 Moreover we found that SIRT1 activator resveratrol (SRV) stimulated significantly the protective effects of moderate Vit C, provided the property of antioxidative stress for the lower and higher concentration of Vit C in ARPE-19 cells as well. Resveratrol 39-50 sirtuin 1 Homo sapiens 23-28 24376725-7 2013 Furthermore, pretreatment with resveratrol depressed motility and tube formation of HCMV-infected ECs, which could be reversed by SIRT1 siRNA. Resveratrol 31-42 sirtuin 1 Homo sapiens 130-135 24330680-3 2013 FINDINGS: Using mouse alpha-cells (alphaTC9), we showed that resveratrol induces expression of pancreatic beta-cell genes such as Pdx1 and Ins2 in a SirT1-dependent manner. Resveratrol 61-72 insulin II Mus musculus 139-143 24095927-7 2013 Resveratrol, a well-known SIRT1 agonist, further enhanced ethanol-induced expression of autophagy-related genes, likely via increased deacetylation of FoxO3a. Resveratrol 0-11 forkhead box O3 Mus musculus 151-157 24145604-10 2013 Furthermore, autophagy inhibitors 3-methyladenine (3-MA), chloroquine as well as ATG5 and BECN1 siRNA significantly attenuated RSV-induced autophagy, which, subsequently, suppressed the downregulation of RSV-induced inflammatory factors expression. Resveratrol 127-130 beclin 1 Homo sapiens 90-95 24145604-10 2013 Furthermore, autophagy inhibitors 3-methyladenine (3-MA), chloroquine as well as ATG5 and BECN1 siRNA significantly attenuated RSV-induced autophagy, which, subsequently, suppressed the downregulation of RSV-induced inflammatory factors expression. Resveratrol 204-207 beclin 1 Homo sapiens 90-95 24145604-11 2013 RSV also increased cAMP (cyclic adenosine monophosphate) content, the expression of PRKA (protein kinase A) and SIRT1 (sirtuin 1), as well as the activity of AMPK (AMP-activated protein kinase). Resveratrol 0-3 sirtuin 1 Homo sapiens 112-117 24145604-11 2013 RSV also increased cAMP (cyclic adenosine monophosphate) content, the expression of PRKA (protein kinase A) and SIRT1 (sirtuin 1), as well as the activity of AMPK (AMP-activated protein kinase). Resveratrol 0-3 sirtuin 1 Homo sapiens 119-128 24145604-12 2013 RSV-induced autophagy in HUVECs was abolished in the presence of inhibitors of ADCY (adenylyl cyclase, KH7), PRKA (H-89), AMPK (compound C), or SIRT1 (nicotinamide and EX-527), as well as ADCY, PRKA, AMPK, and SIRT1 siRNA transfection, indicating that the effects of RSV on autophagy induction were dependent on cAMP, PRKA, AMPK and SIRT1. Resveratrol 0-3 sirtuin 1 Homo sapiens 144-149 24145604-12 2013 RSV-induced autophagy in HUVECs was abolished in the presence of inhibitors of ADCY (adenylyl cyclase, KH7), PRKA (H-89), AMPK (compound C), or SIRT1 (nicotinamide and EX-527), as well as ADCY, PRKA, AMPK, and SIRT1 siRNA transfection, indicating that the effects of RSV on autophagy induction were dependent on cAMP, PRKA, AMPK and SIRT1. Resveratrol 0-3 sirtuin 1 Homo sapiens 210-215 24145604-12 2013 RSV-induced autophagy in HUVECs was abolished in the presence of inhibitors of ADCY (adenylyl cyclase, KH7), PRKA (H-89), AMPK (compound C), or SIRT1 (nicotinamide and EX-527), as well as ADCY, PRKA, AMPK, and SIRT1 siRNA transfection, indicating that the effects of RSV on autophagy induction were dependent on cAMP, PRKA, AMPK and SIRT1. Resveratrol 0-3 sirtuin 1 Homo sapiens 210-215 24145604-13 2013 In conclusion, RSV attenuates endothelial inflammation by inducing autophagy, and the autophagy in part was mediated through the activation of the cAMP-PRKA-AMPK-SIRT1 signaling pathway. Resveratrol 15-18 sirtuin 1 Homo sapiens 162-167 23750556-0 2013 Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Resveratrol 179-190 sirtuin 1 Homo sapiens 116-121 23750556-4 2013 The expression levels of eNOS and silent mating type information regulation 2 homologue 1 (SIRT1) were up-regulated in HUVEC by repeated treatments with 1 muM-resveratrol for 6 d, but not with fenofibrate. Resveratrol 159-170 sirtuin 1 Homo sapiens 91-96 23750556-5 2013 Moreover, resveratrol treatment increased the expression of autophagy-regulated genes such as gamma-aminobutyric acid A receptor-associated protein (GABARAP), microtubule-associated protein 1 light chain 3B (LC3B) and autophagy-related protein 3 (ATG3), the radical scavenger activity-related metallothionein-1X (MT1X) gene and the anti-inflammatory activity-related annexin A2 (ANXA) gene. Resveratrol 10-21 autophagy related 3 Homo sapiens 218-245 23750556-5 2013 Moreover, resveratrol treatment increased the expression of autophagy-regulated genes such as gamma-aminobutyric acid A receptor-associated protein (GABARAP), microtubule-associated protein 1 light chain 3B (LC3B) and autophagy-related protein 3 (ATG3), the radical scavenger activity-related metallothionein-1X (MT1X) gene and the anti-inflammatory activity-related annexin A2 (ANXA) gene. Resveratrol 10-21 autophagy related 3 Homo sapiens 247-251 23943159-3 2013 Recently, integrin alphavbeta3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrotestosterone, and for resveratrol, a polyphenol that has certain estrogen-like features. Resveratrol 196-207 integrin subunit alpha V Homo sapiens 10-30 24064760-0 2013 Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1. Resveratrol 0-11 sirtuin 1 Homo sapiens 129-134 24064760-5 2013 The aim of the present study was to investigate the effects of resveratrol on STAT3 and SIRT1 regarding the proliferation of high glucose-exposed HepG2 cells. Resveratrol 63-74 sirtuin 1 Homo sapiens 88-93 24064760-11 2013 This effect was suppressed by resveratrol (100 microM), and the effect on the p-STAT3 signaling pathway was found to be SIRT1-dependent. Resveratrol 30-41 sirtuin 1 Homo sapiens 120-125 23897750-7 2013 Treatment of BOEC from COPD patients with the SIRT1 activator resveratrol or an ATM inhibitor (KU-55933) also rescued the senescent phenotype. Resveratrol 62-73 sirtuin 1 Homo sapiens 46-51 24282612-10 2013 Using inside out patches from apical membranes of murine cells, resveratrol stimulated an ~8 picosiemens chloride channel consistent with CFTR. Resveratrol 64-75 cystic fibrosis transmembrane conductance regulator Mus musculus 138-142 23878368-2 2013 Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity. Resveratrol 0-11 sirtuin 1 Homo sapiens 185-194 22990594-8 2013 After SIRT1 siRNA was transfected, NP cells decreased phosphorylation of Akt, while resveratrol phosphorylated Akt. Resveratrol 84-95 sirtuin 1 Homo sapiens 6-11 24093677-4 2013 Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kappaB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. Resveratrol 0-11 sirtuin 1 Macaca mulatta 128-137 23884882-9 2013 Similar changes were observed in human islets where the effects of resveratrol were mediated through Sirtuin 1. Resveratrol 67-78 sirtuin 1 Homo sapiens 101-110 24127549-11 2013 Remarkably, inhibition of sirtuin 1 with nicotinamide, increased H2A.Z levels, whereas activation of sirtuin 1 by resveratrol led to an abrupt decrease in H2A.Z. Resveratrol 114-125 sirtuin 1 Homo sapiens 101-110 23902767-6 2013 Here we demonstrate that resveratrol, a naturally occurring polyphenol, increases apoptosis and inhibits adipogenesis along with disruption of PKCdelta alternative splicing during 3T3L1 differentiation. Resveratrol 25-36 protein kinase C, delta Mus musculus 143-151 23272906-3 2013 It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. Resveratrol 23-34 DEP domain containing MTOR interacting protein Homo sapiens 171-177 24147347-0 2013 CFTR chloride channel is a molecular target of the natural cancer preventive agent resveratrol. Resveratrol 83-94 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 24023672-0 2013 Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells. Resveratrol 0-11 histone deacetylase 9 Homo sapiens 21-25 24023672-4 2013 We could show by in silico docking studies that resveratrol has the chemical structure to inhibit the activity of different human HDAC enzymes. Resveratrol 48-59 histone deacetylase 9 Homo sapiens 130-134 24023672-5 2013 In vitro analyses of overall HDAC inhibition and a detailed HDAC profiling showed that resveratrol inhibited all eleven human HDACs of class I, II and IV in a dose-dependent manner. Resveratrol 87-98 histone deacetylase 9 Homo sapiens 29-33 24023672-5 2013 In vitro analyses of overall HDAC inhibition and a detailed HDAC profiling showed that resveratrol inhibited all eleven human HDACs of class I, II and IV in a dose-dependent manner. Resveratrol 87-98 histone deacetylase 9 Homo sapiens 60-64 24023672-8 2013 Testing of resveratrol on hepatoma cell lines HepG2, Hep3B and HuH7 revealed a dose-dependent antiproliferative effect on all cell lines. Resveratrol 11-22 MIR7-3 host gene Homo sapiens 63-67 24023672-13 2013 Moreover, resveratrol may serve as a lead structure for chemical optimization of bioavailability, pharmacology or HDAC inhibition. Resveratrol 10-21 histone deacetylase 9 Homo sapiens 114-118 23651738-0 2013 Resveratrol inhibits LXRalpha-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. Resveratrol 0-11 sestrin 2 Mus musculus 86-94 23651738-10 2013 Moreover, resveratrol up-regulated Sesn2 expression, but not Sesn1 and Sesn3. Resveratrol 10-21 sestrin 2 Mus musculus 35-40 23651738-12 2013 Finally, Sesn2 knockdown using siRNA abolished the effect of resveratrol in LXRalpha-induced FAS luciferase gene transactivation. Resveratrol 61-72 sestrin 2 Mus musculus 9-14 23651738-13 2013 We conclude that resveratrol affects Sesn2 gene induction and contributes to the inhibition of LXRalpha-mediated hepatic lipogenesis. Resveratrol 17-28 sestrin 2 Mus musculus 37-42 23814050-0 2013 Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. Resveratrol 98-109 methionine adenosyltransferase 2B Homo sapiens 0-38 23814050-0 2013 Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. Resveratrol 98-109 sirtuin 1 Homo sapiens 44-53 23814050-3 2013 Interestingly, crystal structure analysis of MAT2B protein (MATbeta) protomer revealed two resveratrol binding pockets, which raises the question of the role of MAT2B in resveratrol biological activities. Resveratrol 91-102 methionine adenosyltransferase 2B Homo sapiens 45-50 23814050-5 2013 Following resveratrol treatment, HuR expression increased first, followed by SIRT1 and MAT2B. Resveratrol 10-21 sirtuin 1 Homo sapiens 77-82 23814050-5 2013 Following resveratrol treatment, HuR expression increased first, followed by SIRT1 and MAT2B. Resveratrol 10-21 methionine adenosyltransferase 2B Homo sapiens 87-92 23814050-10 2013 Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression. Resveratrol 49-60 methionine adenosyltransferase 2B Homo sapiens 13-18 23814050-10 2013 Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression. Resveratrol 102-113 methionine adenosyltransferase 2B Homo sapiens 13-18 23814050-12 2013 In conclusion, resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition. Resveratrol 15-26 sirtuin 1 Homo sapiens 40-45 23814050-12 2013 In conclusion, resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition. Resveratrol 15-26 methionine adenosyltransferase 2B Homo sapiens 51-56 23583951-0 2013 Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Resveratrol 69-80 sirtuin 1 Homo sapiens 8-13 23583951-6 2013 Knockdown of the NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1) by siRNA prevented the upregulation of eNOS mRNA and protein by resveratrol. Resveratrol 136-147 sirtuin 1 Homo sapiens 54-63 23583951-6 2013 Knockdown of the NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1) by siRNA prevented the upregulation of eNOS mRNA and protein by resveratrol. Resveratrol 136-147 sirtuin 1 Homo sapiens 65-70 23583951-13 2013 The SIRT1/FOXO factor axis is involved in resveratrol-induced eNOS transcriptional activation. Resveratrol 42-53 sirtuin 1 Homo sapiens 4-9 23594881-7 2013 In addition, the expression of thyroid-specific genes including TTF1, TTF2, Pax8, and sodium iodide symporter (NIS) was upregulated in both ATC cell lines with resveratrol treatment. Resveratrol 160-171 transcription termination factor 2 Homo sapiens 70-74 23479127-6 2013 Activation of SIRT1 by resveratrol (RSV) or overexpression of SIRT1 attenuated TNF-alpha-induced VAF apoptosis by decreasing the percentage of apoptotic cells and cleaved caspase-3 protein expression and increasing the Bcl-2/Bax ratio. Resveratrol 23-34 sirtuin 1 Homo sapiens 14-19 23479127-6 2013 Activation of SIRT1 by resveratrol (RSV) or overexpression of SIRT1 attenuated TNF-alpha-induced VAF apoptosis by decreasing the percentage of apoptotic cells and cleaved caspase-3 protein expression and increasing the Bcl-2/Bax ratio. Resveratrol 36-39 sirtuin 1 Homo sapiens 14-19 23358928-0 2013 Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway. Resveratrol 0-11 sirtuin 1 Homo sapiens 110-115 23772162-8 2013 MMP-13 mRNA levels in the resveratrol group were significantly decreased than those in the DMSO group at 8 and 16 weeks (P = 0.006 and P = 0.048, respectively). Resveratrol 26-37 collagenase 3 Oryctolagus cuniculus 0-6 23377959-4 2013 Our results revealed that the antioxidant pharmacophore of 2,4-DHS and 2,4,4"-THS, exhibiting higher antioxidant activity than resveratrol, is the 2-hydroxystilbene, rather than 4-hydroxystilbene. Resveratrol 127-138 DHS Homo sapiens 63-66 23022493-0 2013 Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. Resveratrol 0-11 methionine sulfoxide reductase A Homo sapiens 38-71 23022493-3 2013 Here, we firstly provided evidence that pretreatment with a natural polyphenol resveratrol (RSV) up-regulated the expression of MsrA in human neuroblastoma SH-SY5Y cells. Resveratrol 92-95 methionine sulfoxide reductase A Homo sapiens 128-132 23022493-4 2013 It was also observed that the expression and nuclear translocation of forkhead box group O 3a (FOXO3a), a transcription factor that activates the human MsrA promoter, increased after RSV pretreatment. Resveratrol 183-186 methionine sulfoxide reductase A Homo sapiens 152-156 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 81-84 sirtuin 1 Homo sapiens 31-61 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 81-84 sirtuin 1 Homo sapiens 63-68 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 81-84 methionine sulfoxide reductase A Homo sapiens 117-121 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 81-84 sirtuin 1 Homo sapiens 186-191 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 164-167 sirtuin 1 Homo sapiens 31-61 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 164-167 sirtuin 1 Homo sapiens 63-68 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 164-167 methionine sulfoxide reductase A Homo sapiens 117-121 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Resveratrol 164-167 sirtuin 1 Homo sapiens 186-191 23022493-7 2013 In addition, the enhancement of cell resistance to neurotoxins caused by RSV preconditioning can be largely prevented by MsrA inhibitor dimethyl sulfoxide. Resveratrol 73-76 methionine sulfoxide reductase A Homo sapiens 121-125 23022493-8 2013 Our findings suggest that treatment with polyphenols such as RSV can be used as a potential regulatory strategy for MsrA expression and function. Resveratrol 61-64 methionine sulfoxide reductase A Homo sapiens 116-120 23717386-8 2013 These results reveal NAF-1 as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs like pioglitazone and of the natural product resveratrol, both of which interact with the protein and stabilize its labile [2Fe-2S] cluster. Resveratrol 154-165 CDGSH iron sulfur domain 2 Homo sapiens 21-26 23548308-0 2013 Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol. Resveratrol 93-104 sirtuin 1 Homo sapiens 56-61 23548308-3 2013 It regulates nuclear functions such as chromatin remodelling and gene transcription, and it appears to mediate beneficial effects of a low calorie diet which can partly be mimicked by the Sirt1 activating polyphenol resveratrol. Resveratrol 216-227 sirtuin 1 Homo sapiens 188-193 23548308-5 2013 It has a unique N-terminal domain and CTD (C-terminal domain) flanking a conserved Sirtuin catalytic core and these extensions are assumed to mediate Sirt1-specific features such as homo-oligomerization and activation by resveratrol. Resveratrol 221-232 sirtuin 1 Homo sapiens 150-155 23548308-11 2013 Resveratrol, in contrast, activates the Sirt1 catalytic core independent of the terminal domains, indicating a binding site within the catalytic core and suggesting that small molecule activators for other isoforms might also exist. Resveratrol 0-11 sirtuin 1 Homo sapiens 40-45 23592202-1 2013 RATIONALE: The recent discovery of resveratrol"s capability to inhibit cAMP-specific phosphodiesterases (PDEs) and, as a consequence, to enhance particularly the activity of Sirt1 in animal models has reinforced the interest of preventive doping research organizations, especially in PDE4 inhibitors. Resveratrol 35-46 sirtuin 1 Homo sapiens 174-179 23663735-1 2013 Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. Resveratrol 31-42 sirtuin 1 Homo sapiens 103-108 23667712-4 2013 We hypothesized that treatment of endothelial nitric oxide synthase knockout mice (eNOS-/-) and catechol-O-methyltransferase knockout mice (COMT-/-) with resveratrol during pregnancy would improve uterine artery blood flow and therefore ameliorate the PE-like phenotype and FGR in these murine models. Resveratrol 154-165 catechol-O-methyltransferase Mus musculus 96-124 23667712-4 2013 We hypothesized that treatment of endothelial nitric oxide synthase knockout mice (eNOS-/-) and catechol-O-methyltransferase knockout mice (COMT-/-) with resveratrol during pregnancy would improve uterine artery blood flow and therefore ameliorate the PE-like phenotype and FGR in these murine models. Resveratrol 154-165 catechol-O-methyltransferase Mus musculus 140-144 23667712-6 2013 Resveratrol supplementation significantly increased uterine artery blood flow velocity and fetal weight in COMT-/- but not in eNOS-/- mice. Resveratrol 0-11 catechol-O-methyltransferase Mus musculus 107-111 23667712-8 2013 In conclusion, resveratrol increased uterine artery blood flow velocity and fetal weight in COMT-/- mice, suggesting potential as a therapeutic strategy for PE and FGR. Resveratrol 15-26 catechol-O-methyltransferase Mus musculus 92-96 23422569-6 2013 Inhibition of SIRT1 significantly increased vascular superoxide production, enhanced NADPH oxidase activity, and mRNA expression of its subunits p22(phox) and NOX4, which were prevented by resveratrol. Resveratrol 189-200 NADPH oxidase 4 Rattus norvegicus 159-163 23414091-8 2013 Here, we report that carbonylated WT TTR is less amenable to resveratrol-mediated tetramer stabilization than WT TTR. Resveratrol 61-72 transthyretin Homo sapiens 37-40 23262029-10 2013 Further, over-expression of Sirt1 or treatment with the Sirt1 activator resveratrol blocked the increase in Il-6 transcription by MVNP. Resveratrol 72-83 sirtuin 1 Homo sapiens 56-61 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 23-32 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 34-39 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 180-185 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 180-185 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 180-185 23296834-1 2013 To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). Resveratrol 196-207 sirtuin 1 Homo sapiens 180-185 23662249-7 2013 In C2C12 fibroblasts, resveratrol and curcumin can efficiently inhibit myogenic expression and differentiation, for which LSD1 is required. Resveratrol 22-33 lysine demethylase 1A Homo sapiens 122-126 23662249-8 2013 Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds. Resveratrol 94-105 lysine demethylase 1A Homo sapiens 31-35 23662249-8 2013 Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds. Resveratrol 94-105 lysine demethylase 1A Homo sapiens 162-166 23248098-0 2013 Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Resveratrol 8-19 sirtuin 1 Homo sapiens 116-121 23248098-2 2013 Anecdotal and epidemiologic observations provide evidence for beneficial effects of the calorie restriction mimetic resveratrol (RES), a SIRT1 activator in preventing cardiovascular diseases and cancer. Resveratrol 116-127 sirtuin 1 Homo sapiens 137-142 23363613-8 2013 Activation of SIRT1 by exposure to resveratrol significantly reversed the effects of LPS on A549 cells. Resveratrol 35-46 sirtuin 1 Homo sapiens 14-19 23548481-7 2013 In contrast, resveratrol, a SIRT1 activator, induced an alteration in ECs similar to the application of NSS. Resveratrol 13-24 sirtuin 1 Homo sapiens 28-33 23992306-4 2013 The results showed that resveratrol not only inhibited cell proliferation, migration, and invasion in a dose-dependent manner, but also mediated the expression of EMT-related genes (E-cadherin, N-cadherin, vimentin, MMP-2, and MMP-9) which are important for cancer cellular motility, invasiveness and metastasis during tumorigenesis. Resveratrol 24-35 cadherin 2 Homo sapiens 194-204 23992306-4 2013 The results showed that resveratrol not only inhibited cell proliferation, migration, and invasion in a dose-dependent manner, but also mediated the expression of EMT-related genes (E-cadherin, N-cadherin, vimentin, MMP-2, and MMP-9) which are important for cancer cellular motility, invasiveness and metastasis during tumorigenesis. Resveratrol 24-35 matrix metallopeptidase 9 Homo sapiens 227-232 23432678-11 2013 Resveratrol is known to activate cascades involving Wnt and NAD-dependent deacetylase sirtuin-1 (Sirt1). Resveratrol 0-11 sirtuin 1 Homo sapiens 97-102 23090186-8 2013 Furthermore, resveratrol decreased the activity of phosphatidylinositol-3 kinase (PI3K)-Akt phosphorylation and class O forkhead box (FOXO)3a phosphorylation, which resulted in a decrease in B cell leukaemia/lymphoma 2 (BCL-2)-associated X protein (BAX) and increases in BCL-2, superoxide dismutase (SOD)1 and SOD2 production. Resveratrol 13-24 BCL2-associated X protein Mus musculus 249-252 23762150-5 2013 The upregulated expression of alpha -MSH signaling-related molecules beta -catenin, c-Kit, and MITF was suppressed by resveratrol and/or STI571 treatment. Resveratrol 118-129 catenin (cadherin associated protein), beta 1 Mus musculus 69-82 23533494-8 2013 Resveratrol significantly decreased CSC-related Shh expression, Gli-1 nuclear translocation, and cell viability in IL-6-treated HL-60 cells and had synergistic effect with Shh inhibitor cyclopamine on inhibiting cell growth. Resveratrol 0-11 GLI family zinc finger 1 Homo sapiens 64-69 23724859-3 2013 In vitro studies using Caco-2 cells have shown that some polyphenols (quercetin, genistein, resveratrol) may impair OTA efflux through competitive inhibition of MRP2, possibly resulting in an increased systemic availability of OTA. Resveratrol 92-103 ATP binding cassette subfamily C member 2 Homo sapiens 161-165 23936610-4 2013 The aim of this study was to investigate whether resveratrol, a polyphenolic antioxidant compound with tolerogenic effects on DCs, was able to counteract the mechanisms triggered by AGE/RAGE interaction on DCs. Resveratrol 49-60 long intergenic non-protein coding RNA 914 Homo sapiens 186-190 23936610-6 2013 We found that resveratrol exerts an inhibitory effect on DC surface maturation marker and RAGE up-regulation in response to AGE-albumin. Resveratrol 14-25 long intergenic non-protein coding RNA 914 Homo sapiens 90-94 23936610-8 2013 We suggest that resveratrol, by dismantling AGE/RAGE signaling on DCs may prevent or reduce increased reactivity to self-molecules in aging. Resveratrol 16-27 long intergenic non-protein coding RNA 914 Homo sapiens 48-52 24379901-3 2013 In addition to scavenging ROS, resveratrol may have numerous protective effects against age-related disorders, including renal diseases, through the activation of SIRT1. Resveratrol 31-42 sirtuin 1 Homo sapiens 163-168 24379901-5 2013 Previous reports have shown that resveratrol can ameliorate several types of renal injury, such as diabetic nephropathy, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, sepsis-related injury, and unilateral ureteral obstruction, in animal models through its antioxidant effect or SIRT1 activation. Resveratrol 33-44 sirtuin 1 Homo sapiens 310-315 24489988-2 2013 Resveratrol can promote transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) activation, increase the expression level of SIRT-1, which is a sirtuin family protein, and reduce mTOR pathway signaling. Resveratrol 0-11 sirtuin 1 Homo sapiens 141-147 23418481-10 2013 Compounds that were established to increase FXN gene expression and frataxin levels included several anti-cancer agents, the iron-chelator deferiprone and the phytoalexin resveratrol. Resveratrol 171-182 frataxin Mus musculus 44-47 23476126-2 2013 Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. Resveratrol 4-15 tyrosinase Homo sapiens 56-66 23070521-2 2012 At least part of the beneficial effect of resveratrol on human health stems from its capacity to promote autophagy by activating the NAD-dependent deacetylase sirtuin 1. Resveratrol 42-53 sirtuin 1 Homo sapiens 159-168 23070521-7 2012 Inhibition of sirtuin 1 by both pharmacological and genetic means abolished protein deacetylation and autophagy as stimulated by resveratrol, but not by piceatannol, indicating that these compounds act through distinct molecular pathways. Resveratrol 129-140 sirtuin 1 Homo sapiens 14-23 22713680-7 2012 Resveratrol pretreatment provided a significant antinociceptive effect of morphine in morphine-tolerant rats, and it was associated with reversal of the up-regulated NR1 and NR2B subunits in the synaptosome fraction of morphine-tolerant rat spinal cords. Resveratrol 0-11 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 174-178 22713680-9 2012 Furthermore, an increase of postsynaptic density-95/NR1/NR2B complex immunoprecipitation in morphine-tolerant rat spinal cord was also inhibited by resveratrol pretreatment. Resveratrol 148-159 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 56-60 22713680-11 2012 CONCLUSIONS: Resveratrol attenuates morphine tolerance by inhibiting neuroinflammation and down-regulating NMDAR NR1 and NR2B subunit expression. Resveratrol 13-24 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 121-125 23302675-8 2012 Resveratrol also significantly upregulated the protein expression of VASP and increased GSK-3beta Ser(9) phosphorylation, which could lead the inactivation of GSK-3beta. Resveratrol 0-11 vasodilator-stimulated phosphoprotein Rattus norvegicus 69-73 22917537-4 2012 Resveratrol inhibited LPS-induced production of nitric oxide (NO); the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1beta), and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play critical roles in innate immunity, by astrocytes. Resveratrol 0-11 chemokine (C-C motif) ligand 2 Mus musculus 181-211 22917537-4 2012 Resveratrol inhibited LPS-induced production of nitric oxide (NO); the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1beta), and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play critical roles in innate immunity, by astrocytes. Resveratrol 0-11 chemokine (C-C motif) ligand 2 Mus musculus 213-218 22917537-5 2012 Resveratrol also suppressed astrocyte production of IL-12p40 and IL-23, which are known to alter the phenotype of T cells involved in adaptive immunity. Resveratrol 0-11 interleukin 12b Mus musculus 52-60 22917537-6 2012 Finally resveratrol inhibited astrocyte production of C-reactive protein (CRP), which plays a role in a variety of chronic inflammatory disorders. Resveratrol 8-19 C-reactive protein, pentraxin-related Mus musculus 54-72 22917537-6 2012 Finally resveratrol inhibited astrocyte production of C-reactive protein (CRP), which plays a role in a variety of chronic inflammatory disorders. Resveratrol 8-19 C-reactive protein, pentraxin-related Mus musculus 74-77 22883555-4 2012 In order to increase the pool of malonyl-CoA, a key precursor in resveratrol biosynthesis, the acetyl-CoA carboxylase (ACC1) gene was additionally overexpressed in the yeast by replacing the native promoter of the ACC1 gene with the stronger GAL1 promoter and this resulted in enhanced production of resveratrol (4.3 mg/L). Resveratrol 65-76 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 119-123 22883555-4 2012 In order to increase the pool of malonyl-CoA, a key precursor in resveratrol biosynthesis, the acetyl-CoA carboxylase (ACC1) gene was additionally overexpressed in the yeast by replacing the native promoter of the ACC1 gene with the stronger GAL1 promoter and this resulted in enhanced production of resveratrol (4.3 mg/L). Resveratrol 300-311 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 119-123 22497970-7 2012 Resveratrol, as well, also had a beneficial effect on the ratios of expressions of Bcl-2/Bax and levels of malondialdehyde/glutathione peroxidase. Resveratrol 0-11 BCL2-associated X protein Mus musculus 89-92 22608985-9 2012 Similarly, overexpression of silent mating type information regulation 2 homolog 1 (SIRT1), a gene upstream of PGC-1alpha, or the SIRT1 activator resveratrol restored Aldo-induced MtD and EMT by upregulating PGC-1alpha. Resveratrol 146-157 sirtuin 1 Homo sapiens 130-135 22784284-8 2012 The experimental results indicated that RSV significantly decreased oxidative stress (superoxide anion content, protein carbonyl level and Mn-SOD expression) in both tissues and hepatic inflammation (NF- kappaB and IL-1 beta ), but implicated proinflammatory potential of RSV in diabetic spleen (TNF-alpha and IL-6). Resveratrol 40-43 superoxide dismutase 2 Rattus norvegicus 139-145 22640743-4 2012 The ectopic expression of either SIRT1 or resveratrol (an activator of SIRT1) suppressed levels of beta-catenin protein and its transcriptional activity in Panc-PAUF cells. Resveratrol 42-53 sirtuin 1 Homo sapiens 71-76 22564731-4 2012 Treatment with resveratrol, a SIRT1 activator significantly inhibited palmitate-induced ER stress, leading to the protection against palmitate-induced ER stress and insulin resistance. Resveratrol 15-26 sirtuin 1 Homo sapiens 30-35 22564731-5 2012 Resveratrol and SIRT1 overexpression induced the expression of oxygen-regulated protein (ORP) 150 in HepG2 cells. Resveratrol 0-11 hypoxia up-regulated 1 Homo sapiens 63-97 22822544-8 2012 Literature has reported that resveratrol led to post-transcriptional regulation of tyrosinase. Resveratrol 29-40 tyrosinase Homo sapiens 83-93 22822544-10 2012 Surprisingly, the combination of 4-n-butylresorcinol and resveratrol reduced tyrosinase levels. Resveratrol 57-68 tyrosinase Homo sapiens 77-87 22822544-11 2012 Therefore, these results indicate that the synergistic hypopigmentary effect of 4-n-butylresorcinol and resveratrol results from a decreased level of tyrosinase possibly resulting from synergistic action of 4-n-butylresorcinol on tyrosinase alteration by resveratrol. Resveratrol 104-115 tyrosinase Homo sapiens 150-160 22331300-8 2012 Importantly, dietary supplementation of resveratrol (RSV), a naturally occurring antioxidant/anti-inflammatory polyphenol, markedly reduced the levels of T(H)17 cells, IL-17A and MMPs, and elevated the levels of tight junction proteins, which improved the BBB integrity in Ppt1-KO mice. Resveratrol 40-51 interleukin 17A Mus musculus 168-174 22331300-8 2012 Importantly, dietary supplementation of resveratrol (RSV), a naturally occurring antioxidant/anti-inflammatory polyphenol, markedly reduced the levels of T(H)17 cells, IL-17A and MMPs, and elevated the levels of tight junction proteins, which improved the BBB integrity in Ppt1-KO mice. Resveratrol 40-51 palmitoyl-protein thioesterase 1 Mus musculus 273-277 22331300-8 2012 Importantly, dietary supplementation of resveratrol (RSV), a naturally occurring antioxidant/anti-inflammatory polyphenol, markedly reduced the levels of T(H)17 cells, IL-17A and MMPs, and elevated the levels of tight junction proteins, which improved the BBB integrity in Ppt1-KO mice. Resveratrol 53-56 interleukin 17A Mus musculus 168-174 22331300-8 2012 Importantly, dietary supplementation of resveratrol (RSV), a naturally occurring antioxidant/anti-inflammatory polyphenol, markedly reduced the levels of T(H)17 cells, IL-17A and MMPs, and elevated the levels of tight junction proteins, which improved the BBB integrity in Ppt1-KO mice. Resveratrol 53-56 palmitoyl-protein thioesterase 1 Mus musculus 273-277 22331300-9 2012 Intriguingly, we found that RSV suppressed the differentiation of CD4(+) T lymphocytes to IL-17A-positive T(H)17 cells. Resveratrol 28-31 CD4 antigen Mus musculus 66-69 22331300-9 2012 Intriguingly, we found that RSV suppressed the differentiation of CD4(+) T lymphocytes to IL-17A-positive T(H)17 cells. Resveratrol 28-31 interleukin 17A Mus musculus 90-96 22560207-3 2012 establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012). Resveratrol 130-141 sirtuin 1 Homo sapiens 108-113 22245142-0 2012 Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells. Resveratrol 0-11 BCL2 antagonist/killer 1 Homo sapiens 36-39 22245142-6 2012 Collectively, our findings for the first time demonstrate that RV induces apoptosis dominantly via a Bak- but not Bax-mediated AIF-dependent mitochondrial apoptotic signaling pathway in which Bim but not Puma and Noxa may supply the force to trigger Bak activation and subsequent apoptosis in both ASTC-a-1 and A549 cell lines. Resveratrol 63-65 BCL2 antagonist/killer 1 Homo sapiens 101-104 22245142-6 2012 Collectively, our findings for the first time demonstrate that RV induces apoptosis dominantly via a Bak- but not Bax-mediated AIF-dependent mitochondrial apoptotic signaling pathway in which Bim but not Puma and Noxa may supply the force to trigger Bak activation and subsequent apoptosis in both ASTC-a-1 and A549 cell lines. Resveratrol 63-65 BCL2 antagonist/killer 1 Homo sapiens 250-253 22327552-5 2012 In addition, resveratrol strongly stimulates SIRT1 deacetylase activity in a dose-dependent manner by increasing its binding affinity to both the acetylated substrate and NAD(+). Resveratrol 13-24 sirtuin 1 Homo sapiens 45-50 22403148-5 2012 DEVELOPMENT: It has been suggested that the daily consumption of red wine, and therefore of resveratrol, could account for the so-called "French paradox", according to which the population in the south of France, despite eating a diet that is relatively high in saturated fats, presents a low risk of heart disease. Resveratrol 92-103 chromosome 10 open reading frame 90 Homo sapiens 272-276 22015446-5 2012 We found that pretreatment with resveratrol (10muM) 6h prior to high glucose treatment significantly reduced hyperglycemia-induced increase in reactive oxygen species (ROS) production and mitochondrial superoxide generation, as well as stimulated MnSOD activity. Resveratrol 32-43 superoxide dismutase 2 Rattus norvegicus 247-252 22330808-8 2012 Further, treatment of cisplatin-treated HK2 cells with resveratrol, a SIRT1 activator, also decreased acetylation of NF-kappaB p65 subunit and cisplatin-induced increase of the cell viability in HK2 cells. Resveratrol 55-66 sirtuin 1 Homo sapiens 70-75 22436213-2 2012 In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Resveratrol 92-103 sirtuin 1 Homo sapiens 116-121 22125309-0 2012 Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Resveratrol 95-106 sirtuin 1 Homo sapiens 0-9 23450206-10 2012 Resveratrol reduces the extent of atherosclerosis in animal model of atherosclerosis (apolipoprotein [Apo] E-deficient and Apo E(-/-)/low-density lipoprotein receptor-deficient mice and macrophage). Resveratrol 0-11 low density lipoprotein receptor Mus musculus 134-166 23554738-8 2012 The inhibitory effect of resveratrol (10 and 50 micromol/L) on the proliferation of rat VSMCs in the NQO2 siRNA group was significantly weaker than that in the normal and scrambled siRNA group (P < 0.01). Resveratrol 25-36 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 101-105 23554738-11 2012 In conclusion, high concentration of resveratrol inhibits angiotensin II-induced ERK1/2 phosphorylation and subsequent proliferation by down-regulation of NQO2 in cultured rat VSMCs. Resveratrol 37-48 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 155-159 21191669-3 2012 In this study, we investigated a putative role of NHE-1 and NHE-3 isoforms in the RSVL-induced cell death using MDA-MB-231 estrogen receptor-negative [ER-] and MCF-7 [ER+] human breast cancer cell lines. Resveratrol 82-86 solute carrier family 9 member A3 Homo sapiens 60-65 21191669-6 2012 RSVL caused a dose- and time-dependent induction of NHE-1 and NHE-3 proteins in both cancer cell lines as shown by ECL Western blot analysis and fluorescence measurement. Resveratrol 0-4 solute carrier family 9 member A3 Homo sapiens 62-67 21191669-8 2012 Thus, it is concluded that RSVL-inhibited cell growth and viability, increased cell size, and volume along with an increased apoptotic activity are due to the induction of NHE-1 and NHE-3 isoforms in the present breast cancer cell lines. Resveratrol 27-31 solute carrier family 9 member A3 Homo sapiens 182-187 22245592-2 2012 In this study, we investigated the role of SIRT1 signaling in the hypoxic down-regulations of c-Myc and beta-catenin and hypoxic preconditioning effect of the red wine polyphenols such as piceatannol, myricetin, quercetin and resveratrol. Resveratrol 226-237 sirtuin 1 Homo sapiens 43-48 22245592-6 2012 We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning. Resveratrol 57-68 sirtuin 1 Homo sapiens 157-162 21914146-0 2012 Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas. Resveratrol 0-11 vascular endothelial growth factor A Mus musculus 63-97 21914146-3 2012 The aim of this study is to investigate the effects of resveratrol, a natural plant-derived phytoalexin, on vascular damage and VEGF induction in mouse retinas of early diabetes. Resveratrol 55-66 vascular endothelial growth factor A Mus musculus 128-132 21914146-8 2012 RESULTS: Diabetes led to increase vessel leakage, pericyte loss and VEGF protein level in the mouse retinas compared with controls; however, these changes were effectively blocked by resveratrol treatment. Resveratrol 183-194 vascular endothelial growth factor A Mus musculus 68-72 21914146-9 2012 CONCLUSION: Our data suggest that resveratrol is effective to decrease vascular lesions and VEGF induction in mouse retinas of early diabetes. Resveratrol 34-45 vascular endothelial growth factor A Mus musculus 92-96 21369944-0 2012 Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation. Resveratrol 28-39 interleukin 17A Homo sapiens 66-71 21369944-5 2012 We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro. Resveratrol 36-47 interleukin 17A Homo sapiens 92-97 22118570-6 2012 Consequently, downstream phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3 upon LPS stimulation was also inhibited by resveratrol. Resveratrol 154-165 signal transducer and activator of transcription 1 Homo sapiens 44-100 22118570-8 2012 Resveratrol treatment also prevented the pro-inflammatory effect of fibrillar Abeta on macrophages by potently inhibiting the effect of Abeta on IkappaB phosphorylation, activation of STAT1 and STAT3, and on tumor necrosis factor-alpha and interleukin-6 secretion. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 184-189 22041555-0 2012 Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Resveratrol 41-52 solute carrier family 6 member 3 Homo sapiens 74-94 22044919-0 2012 Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity. Resveratrol 0-11 sirtuin 1 Homo sapiens 131-136 22044919-1 2012 In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-kappaB). Resveratrol 17-28 sirtuin 1 Homo sapiens 40-45 22044919-2 2012 Given that SIRT1 inhibits the transactivation potential of NF-kappaB by deacetylating acetylated lysines in p65, the NF-kappaB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. Resveratrol 167-178 sirtuin 1 Homo sapiens 11-16 22044919-2 2012 Given that SIRT1 inhibits the transactivation potential of NF-kappaB by deacetylating acetylated lysines in p65, the NF-kappaB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. Resveratrol 167-178 sirtuin 1 Homo sapiens 189-194 22044919-4 2012 Resveratrol-activated SIRT1 mediated this suppression. Resveratrol 0-11 sirtuin 1 Homo sapiens 22-27 22044919-8 2012 Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis. Resveratrol 0-11 sirtuin 1 Homo sapiens 32-37 22166204-0 2012 Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Resveratrol 0-11 F-box protein 32 Homo sapiens 102-111 22166204-0 2012 Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Resveratrol 0-11 sirtuin 1 Homo sapiens 153-158 22166204-3 2012 In addition, the role of the deacetylase SIRT1 in the effects of resveratrol was determined by transfecting myotubes with SIRT1 siRNA. Resveratrol 65-76 sirtuin 1 Homo sapiens 41-46 22166204-3 2012 In addition, the role of the deacetylase SIRT1 in the effects of resveratrol was determined by transfecting myotubes with SIRT1 siRNA. Resveratrol 65-76 sirtuin 1 Homo sapiens 122-127 22166204-4 2012 The catabolic effects of dexamethasone were prevented by resveratrol and the protective effects of resveratrol on dexamethasone-induced atrogin-1 and MuRF1 expression were abolished in myotubes transfected with SIRT1 siRNA. Resveratrol 99-110 F-box protein 32 Homo sapiens 136-145 22166204-4 2012 The catabolic effects of dexamethasone were prevented by resveratrol and the protective effects of resveratrol on dexamethasone-induced atrogin-1 and MuRF1 expression were abolished in myotubes transfected with SIRT1 siRNA. Resveratrol 99-110 sirtuin 1 Homo sapiens 211-216 22166204-5 2012 Results suggest that resveratrol can prevent glucocorticoid-induced muscle wasting and that this effect is at least in part SIRT1-dependent. Resveratrol 21-32 sirtuin 1 Homo sapiens 124-129 22760199-6 2012 RESULTS: XIAP KD cells were more sensitive to etoposide, Rsv, vincristine and doxorubicin compared to wild-type (WT) cells. Resveratrol 57-60 X-linked inhibitor of apoptosis Homo sapiens 9-13 22953035-5 2012 For example, the natural antioxidant and sirtuin 1 activator resveratrol has been shown to have beneficial effects in animal models of disease. Resveratrol 61-72 sirtuin 1 Homo sapiens 41-50 23185430-4 2012 Here we show that resveratrol inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1, against fluorophore-labeled peptide substrates but also against peptides and proteins lacking the non-physiological fluorophore modification. Resveratrol 18-29 sirtuin 1 Homo sapiens 88-93 23056585-5 2012 The effect of SIRT1 was mimicked by treatment with resveratrol, a well known activator of SIRT1, which has no effect in neurons overexpressing SIRT1H363Y indicating that the effect of resveratrol was specifically mediated by SIRT1. Resveratrol 51-62 sirtuin 1 Homo sapiens 14-19 23056585-5 2012 The effect of SIRT1 was mimicked by treatment with resveratrol, a well known activator of SIRT1, which has no effect in neurons overexpressing SIRT1H363Y indicating that the effect of resveratrol was specifically mediated by SIRT1. Resveratrol 51-62 sirtuin 1 Homo sapiens 90-95 23056585-5 2012 The effect of SIRT1 was mimicked by treatment with resveratrol, a well known activator of SIRT1, which has no effect in neurons overexpressing SIRT1H363Y indicating that the effect of resveratrol was specifically mediated by SIRT1. Resveratrol 51-62 sirtuin 1 Homo sapiens 90-95 23056585-5 2012 The effect of SIRT1 was mimicked by treatment with resveratrol, a well known activator of SIRT1, which has no effect in neurons overexpressing SIRT1H363Y indicating that the effect of resveratrol was specifically mediated by SIRT1. Resveratrol 184-195 sirtuin 1 Homo sapiens 14-19 22962611-7 2012 We found that mice fed resveratrol showed reduced OVA-specific serum IgE production, anaphylactic reaction, and OVA-induced IL-13 and IFN-a production from the mesenteric lymph nodes (MLNs) and spleens in comparison to the control mice, following oral sensitization with OVA plus CT. Resveratrol 23-34 interferon alpha Mus musculus 134-139 22962611-8 2012 In addition, resveratrol inhibited OVA plus CT-induced IL-4, IL-13, and IFN-a production in splenocytes from DO11.10 mice associated with inhibition of GATA-3 and T-bet expression. Resveratrol 13-24 interferon alpha Mus musculus 72-77 22962611-8 2012 In addition, resveratrol inhibited OVA plus CT-induced IL-4, IL-13, and IFN-a production in splenocytes from DO11.10 mice associated with inhibition of GATA-3 and T-bet expression. Resveratrol 13-24 T-box 21 Mus musculus 163-168 22962611-9 2012 Furthermore, resveratrol suppressed the OVA plus CT-induced CD25 expression and IL-2 production in DO11.10 mice-splenocytes in association with decreases in CD80 and CD86 expression levels. Resveratrol 13-24 interleukin 2 receptor, alpha chain Mus musculus 60-64 22539994-0 2012 Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. Resveratrol 0-11 sirtuin 1 Homo sapiens 35-41 22539994-2 2012 This study determined whether activation of Sirt-1 (a NAD(+)-dependent histone deacetylase) by the phytoestrogen resveratrol affects osteogenic differentiation. Resveratrol 113-124 sirtuin 1 Homo sapiens 44-50 22539994-7 2012 Activation of Sirt-1 by resveratrol in MSCs increased its binding to PPAR-gamma and repressed PPAR-gamma activity by involving its cofactor NCoR (nuclear receptor co-repressor). Resveratrol 24-35 sirtuin 1 Homo sapiens 14-20 22539994-8 2012 The modulatory effects of resveratrol on nicotinamide-induced expression of PPAR-gamma and its cofactor NCoR were found to be mediated, at least in part, by Sirt-1/Runx2 association and deacetylation of Runx2. Resveratrol 26-37 sirtuin 1 Homo sapiens 157-163 22539994-9 2012 Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. Resveratrol 152-163 sirtuin 1 Homo sapiens 22-28 22493735-6 2012 Stimulation of Sirt1 by resveratrol or virus-driven overexpression robustly diminished resistin mRNA and protein expression in macrophages, whereas down-regulation of Sirt1 triggered a large increase in resistin expression. Resveratrol 24-35 sirtuin 1 Homo sapiens 15-20 22074828-3 2011 We aimed to investigate the different effects of three representative flavonoids-hesperidin, naringin, and resveratrol-on intracellular adhesion molecule-1 (ICAM-1) induction in human umbilical vein endothelial cells (HUVECs) by using high-glucose (HG) concentrations and the possible underlying molecular mechanisms. Resveratrol 107-118 intercellular adhesion molecule 1 Homo sapiens 122-155 22074828-3 2011 We aimed to investigate the different effects of three representative flavonoids-hesperidin, naringin, and resveratrol-on intracellular adhesion molecule-1 (ICAM-1) induction in human umbilical vein endothelial cells (HUVECs) by using high-glucose (HG) concentrations and the possible underlying molecular mechanisms. Resveratrol 107-118 intercellular adhesion molecule 1 Homo sapiens 157-163 22074828-10 2011 This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells. Resveratrol 55-66 intercellular adhesion molecule 1 Homo sapiens 90-96 21225623-5 2011 Resveratrol and triacetyl-resveratrol interacted avidly and specifically with integrin alphavbeta3 through binding at the site targeted by the high affinity cyclic Arg-Gly-Asp (RGD) peptide. Resveratrol 0-11 integrin subunit alpha V Homo sapiens 78-98 21850487-0 2011 Resveratrol pretreatment attenuates cerebral ischemic injury by upregulating expression of transcription factor Nrf2 and HO-1 in rats. Resveratrol 0-11 heme oxygenase 1 Rattus norvegicus 121-125 21850487-15 2011 Resveratrol pretreatment significantly ameliorated neurological scores, reduced infarct volume and brain water content, decreased MDA levels, restored the SOD activity, upregulated the protein and mRNA expression of Nrf2 and HO-1, downregulated the protein expression of caspase-3. Resveratrol 0-11 heme oxygenase 1 Rattus norvegicus 225-229 22029500-5 2011 The anti-inflammatory effects of resveratrol were indicated by lowered myeloperoxidase activity, and by suppressing ICAM-1 and VCAM-1 levels in the colon and serum. Resveratrol 33-44 intercellular adhesion molecule 1 Rattus norvegicus 116-122 21946130-2 2011 In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and aging, by modulating the mammalian silent information regulator 1 (SIRT1) of the sirtuin family. Resveratrol 13-24 sirtuin 1 Homo sapiens 136-166 21946130-2 2011 In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and aging, by modulating the mammalian silent information regulator 1 (SIRT1) of the sirtuin family. Resveratrol 13-24 sirtuin 1 Homo sapiens 168-173 21896316-0 2011 Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis. Resveratrol 22-33 sirtuin 1 Homo sapiens 63-68 21896316-1 2011 Resveratrol has recently been widely reported to be an age-delaying and neuroprotective compound, and it appears to produce these benefits by activating silent mating type information regulation 2 homolog 1 (SIRT1). Resveratrol 0-11 sirtuin 1 Homo sapiens 208-213 21896316-6 2011 These findings suggest that resveratrol can protect the ALS cell model from mutant SOD1-mediated toxicity through up-regulating the expression of SIRT1, which represents a potential therapeutic target for preventing the motor neuron degeneration in ALS patients. Resveratrol 28-39 sirtuin 1 Homo sapiens 146-151 21683516-3 2011 Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol 0-11 CD8a molecule Homo sapiens 180-183 21905824-3 2011 Resveratrol, a polyphenol found in many plant species, exerts protective effects on endothelial cells through activation of SIRT1. Resveratrol 0-11 sirtuin 1 Homo sapiens 124-129 21905824-4 2011 The aims of this work were to explore whether BTM-0512, a novel derivative of resveratrol, is able to exert beneficial effects on high glucose-induced dysfunction of endothelial cells through regulation of SIRT1. Resveratrol 78-89 sirtuin 1 Homo sapiens 206-211 21723843-11 2011 Luciferase assays indicated that resveratrol suppressed the transcriptional activity of XBP1s through sirtuin 1, a downstream molecular target of resveratrol. Resveratrol 33-44 sirtuin 1 Homo sapiens 102-111 21723843-11 2011 Luciferase assays indicated that resveratrol suppressed the transcriptional activity of XBP1s through sirtuin 1, a downstream molecular target of resveratrol. Resveratrol 146-157 sirtuin 1 Homo sapiens 102-111 21723843-12 2011 Chromatin immunoprecipitation studies revealed that resveratrol decreased the DNA binding capacity of XBP1 and increased the enrichment of sirtuin 1 at the XBP1 binding region in the XBP1 promoter. Resveratrol 52-63 sirtuin 1 Homo sapiens 139-148 21713995-0 2011 Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. Resveratrol 0-11 sirtuin 1 Homo sapiens 112-117 21713995-1 2011 Reports of the bone-protective effects of resveratrol, a naturally occurring phytoestrogen and agonist for the longevity gene SIRT1, have highlighted this compound as a candidate for therapy of osteoporosis. Resveratrol 42-53 sirtuin 1 Homo sapiens 126-131 21713995-3 2011 There has been speculation that resveratrol can promote osteogenesis through SIRT1, but the mechanism remains unclear. Resveratrol 32-43 sirtuin 1 Homo sapiens 77-82 21713995-7 2011 Furthermore, we found that the osteogenic effect of resveratrol was mediated mainly through SIRT1/FOXO3A with a smaller contribution from the estrogenic pathway. Resveratrol 52-63 sirtuin 1 Homo sapiens 92-97 21713995-8 2011 Resveratrol activated SIRT1 activity and enhanced FOXO3A protein expression, a known target of SIRT1, in an independent manner. Resveratrol 0-11 sirtuin 1 Homo sapiens 22-27 21713995-8 2011 Resveratrol activated SIRT1 activity and enhanced FOXO3A protein expression, a known target of SIRT1, in an independent manner. Resveratrol 0-11 sirtuin 1 Homo sapiens 95-100 21713995-9 2011 As a result, resveratrol increased the amount of the SIRT1-FOXO3A complex and enhanced FOXO3A-dependent transcriptional activity. Resveratrol 13-24 sirtuin 1 Homo sapiens 53-58 21713995-10 2011 Ectopic overexpression or silencing of SIRT1/FOXO3A expression regulated RUNX2 promoter activity, suggesting an important role for SIRT1-FOXO3A complex in regulating resveratrol-induced RUNX2 gene transcription. Resveratrol 166-177 sirtuin 1 Homo sapiens 39-44 21713995-10 2011 Ectopic overexpression or silencing of SIRT1/FOXO3A expression regulated RUNX2 promoter activity, suggesting an important role for SIRT1-FOXO3A complex in regulating resveratrol-induced RUNX2 gene transcription. Resveratrol 166-177 sirtuin 1 Homo sapiens 131-136 21713995-11 2011 Further mutational RUNX2 promoter analysis and chromatin immunoprecipitation assay revealed that resveratrol-induced SIRT1-FOXO3A complex bound to a distal FOXO response element (-1269/-1263), an action that transactivated RUNX2 promoter activity in vivo. Resveratrol 97-108 sirtuin 1 Homo sapiens 117-122 21713995-12 2011 Taken together, our results describe a novel mechanism of resveratrol in promoting osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. Resveratrol 58-69 sirtuin 1 Homo sapiens 174-179 21189227-0 2011 Resveratrol down-regulates interferon-gamma-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 123-129 21189227-6 2011 Moreover, resveratrol diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10 or MIG as well as inhibited IFN-gamma-induced promoter activity of iNOS gene, indicating that the phytoalexin could down-regulate inflammatory genes at the transcription level. Resveratrol 10-21 C-X-C motif chemokine ligand 10 Homo sapiens 131-136 21189227-7 2011 To understand a mechanism of the action, we tested resveratrol could affect the signal transducers and activation of transcription-1 (STAT-1), a pivotal transcription factor in IFN-gamma-induced expression of inflammatory genes. Resveratrol 51-62 signal transducer and activator of transcription 1 Homo sapiens 80-132 21189227-7 2011 To understand a mechanism of the action, we tested resveratrol could affect the signal transducers and activation of transcription-1 (STAT-1), a pivotal transcription factor in IFN-gamma-induced expression of inflammatory genes. Resveratrol 51-62 signal transducer and activator of transcription 1 Homo sapiens 134-140 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 68-74 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 157-163 21189227-11 2011 Taken together, this study proposes a new mechanism of resveratrol, blocking JAK/STAT-1 pathway that controls inflammatory responses in IFN-gamma-activated macrophages. Resveratrol 55-66 signal transducer and activator of transcription 1 Homo sapiens 81-87 21856773-8 2011 LMP1 oncogene, which is expressed in latency III phenotype, is involved with the higher resistance to the antiproliferative effect of resveratrol because siRNA-mediated inhibition of LMP1 greatly increased the sensitivity of latency III BL cells as well as that of lymphoblastoid cell lines to the polyphenol. Resveratrol 134-145 PDZ and LIM domain 7 Homo sapiens 0-4 21856773-8 2011 LMP1 oncogene, which is expressed in latency III phenotype, is involved with the higher resistance to the antiproliferative effect of resveratrol because siRNA-mediated inhibition of LMP1 greatly increased the sensitivity of latency III BL cells as well as that of lymphoblastoid cell lines to the polyphenol. Resveratrol 134-145 PDZ and LIM domain 7 Homo sapiens 183-187 20730501-5 2011 RSV reversed surface phenotypes of old mice to that of young mice by maintaining the CD4+ and CD8+ population in splenocytes as well as reducing CD8+CD44+ (CD8M) cells in the aged. Resveratrol 0-3 CD4 antigen Mus musculus 85-88 20730501-5 2011 RSV reversed surface phenotypes of old mice to that of young mice by maintaining the CD4+ and CD8+ population in splenocytes as well as reducing CD8+CD44+ (CD8M) cells in the aged. Resveratrol 0-3 CD44 antigen Mus musculus 149-153 21666113-3 2011 We measured the responses of cerebral arterioles in untreated and resveratrol-treated (10 mg kg(-1) day(-1)) nondiabetic and diabetic rats to endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase (NOS)-dependent agonists and to a NOS-independent agonist. Resveratrol 66-77 nitric oxide synthase 3 Rattus norvegicus 155-159 21666113-3 2011 We measured the responses of cerebral arterioles in untreated and resveratrol-treated (10 mg kg(-1) day(-1)) nondiabetic and diabetic rats to endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase (NOS)-dependent agonists and to a NOS-independent agonist. Resveratrol 66-77 nitric oxide synthase 1 Rattus norvegicus 175-179 21666113-7 2011 While resveratrol did not alter responses in nondiabetic rats, resveratrol prevented T1D-induced impairment in eNOS- and nNOS-dependent vasodilation. Resveratrol 63-74 nitric oxide synthase 3 Rattus norvegicus 111-115 21666113-7 2011 While resveratrol did not alter responses in nondiabetic rats, resveratrol prevented T1D-induced impairment in eNOS- and nNOS-dependent vasodilation. Resveratrol 63-74 nitric oxide synthase 1 Rattus norvegicus 121-125 21666113-9 2011 Furthermore, eNOS and nNOS protein were increased in diabetic rats and resveratrol produced a further increased eNOS and nNOS proteins. Resveratrol 71-82 nitric oxide synthase 3 Rattus norvegicus 112-116 21666113-9 2011 Furthermore, eNOS and nNOS protein were increased in diabetic rats and resveratrol produced a further increased eNOS and nNOS proteins. Resveratrol 71-82 nitric oxide synthase 1 Rattus norvegicus 121-125 21666113-10 2011 SOD-1 and SOD-2 proteins were not altered by T1D, but resveratrol treatment produced a decrease in SOD-2 protein. Resveratrol 54-65 superoxide dismutase 2 Rattus norvegicus 99-104 21633290-0 2011 Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. Resveratrol 13-24 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 51-54 21633290-1 2011 This study explored the efficacy of curcumin and resveratrol in maintaining adequate zinc levels to regulate p21 and cyclooxygenase-2 (cox-2) during benzo[a]pyrene (BP)-induced lung carcinogenesis. Resveratrol 49-60 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 109-112 21633290-5 2011 Interestingly, combined supplementation of curcumin and resveratrol to BP-treated mice resulted in an appreciable improvement in the zinc levels and protein expression of p21. Resveratrol 56-67 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 171-174 21633290-7 2011 This study, therefore, concludes that combined treatment with curcumin and resveratrol maintains adequate zinc levels and regulates inflammation by cox-2 and cell cycle arrest by p21 during lung carcinogenesis in mice. Resveratrol 75-86 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 179-182 21109418-6 2011 Expression of resistin and RBP4 was reduced in both adipocyte models following resveratrol treatment. Resveratrol 79-90 retinol binding protein 4, plasma Mus musculus 27-31 21689891-4 2011 We hypothesize that resveratrol treatment and subsequent activation of SIRT1 pathway might be highly beneficial for patients with DFS. Resveratrol 20-31 sirtuin 1 Homo sapiens 71-76 21736731-0 2011 Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Resveratrol 0-11 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 57-60 21736731-4 2011 The aim of our present study was to test whether resveratrol, a polyphenolic compound with known analgesic activity, can regulate Cdk5/p35 activity. Resveratrol 49-60 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 135-138 21736731-6 2011 Our studies demonstrate that resveratrol inhibits p35 promoter activity and also blocks the TNF-alpha mediated increase in Cdk5 activity in PC12 cells. Resveratrol 29-40 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 50-53 21736731-7 2011 Resveratrol also inhibits p35 expression and blocks the TNF-alpha mediated increase in Cdk5 activity in DRG neurons. Resveratrol 0-11 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 26-29 21736731-8 2011 In the presence of resveratrol, the MEK inhibitor decreased p35 promoter activity, whereas the inhibitors of p38 MAPK, JNK and NF-kappaB increased p35 promoter activity, indicating that these pathways regulate p35 expression differently. Resveratrol 19-30 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 60-63 21736731-10 2011 CONCLUSIONS: We demonstrate here that resveratrol regulates p35 promoter activity in PC12 cells and DRG neurons. Resveratrol 38-49 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 60-63 21736731-11 2011 Most importantly, resveratrol blocks the TNF-alpha-mediated increase in p35 promoter activity, thereby reducing p35 expression and subsequent Cdk5 kinase activity. Resveratrol 18-29 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 72-75 21736731-11 2011 Most importantly, resveratrol blocks the TNF-alpha-mediated increase in p35 promoter activity, thereby reducing p35 expression and subsequent Cdk5 kinase activity. Resveratrol 18-29 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 112-115 21810449-6 2011 After interfering with the expression of SIRT1 using SIRT1 siRNA, the effects of resveratrol on NO secretion were impaired. Resveratrol 81-92 sirtuin 1 Homo sapiens 41-46 21810449-5 2011 Compared with control cells, high glucose decreased nitric oxide (NO) secretion, but resveratrol treatment increased the expression of SIRT1 and the secretion of NO. Resveratrol 85-96 sirtuin 1 Homo sapiens 135-140 21439372-6 2011 Similarly, mRNA and protein analyses substantiated that resveratrol treatment notably normalizes the renal expression of Nrf2/Keap1and its downstream regulatory proteins in the diabetic group of rats. Resveratrol 56-67 Kelch-like ECH-associated protein 1 Rattus norvegicus 126-131 21966552-4 2011 RSV treatment has no effect on the expression levels of mTOR, raptor and DEPTOR, but greatly promotes the interaction between mTOR and its inhibitor DEPTOR. Resveratrol 0-3 DEP domain containing MTOR interacting protein Homo sapiens 149-155 21378393-7 2011 Inhibition of sirtuin 1 (SIRT1) by Sirtinol and the use of peroxisome proliferator-activated receptor gamma co-activator-1-alpha (PGC-1alpha) small interfering RNAs demonstrate that the RSV-induced stimulation of FAO requires the presence of PGC-1alpha and SIRT1. Resveratrol 186-189 sirtuin 1 Homo sapiens 14-23 21378393-7 2011 Inhibition of sirtuin 1 (SIRT1) by Sirtinol and the use of peroxisome proliferator-activated receptor gamma co-activator-1-alpha (PGC-1alpha) small interfering RNAs demonstrate that the RSV-induced stimulation of FAO requires the presence of PGC-1alpha and SIRT1. Resveratrol 186-189 sirtuin 1 Homo sapiens 25-30 21378393-7 2011 Inhibition of sirtuin 1 (SIRT1) by Sirtinol and the use of peroxisome proliferator-activated receptor gamma co-activator-1-alpha (PGC-1alpha) small interfering RNAs demonstrate that the RSV-induced stimulation of FAO requires the presence of PGC-1alpha and SIRT1. Resveratrol 186-189 sirtuin 1 Homo sapiens 257-262 21340626-7 2011 Gene array analysis indicated a dramatic decrease in expression of Ccr6, which encodes chemokine (C-C motif) receptor (CCR) 6, in the splenocytes from resveratrol-treated mice. Resveratrol 151-162 chemokine (C-C motif) receptor 6 Mus musculus 67-71 21340626-7 2011 Gene array analysis indicated a dramatic decrease in expression of Ccr6, which encodes chemokine (C-C motif) receptor (CCR) 6, in the splenocytes from resveratrol-treated mice. Resveratrol 151-162 chemokine (C-C motif) receptor 6 Mus musculus 98-125 21340626-8 2011 CCR6 abundance on IL-17-producing cells and CD11b(+)F4/80(hi) macrophages was inhibited by resveratrol treatment. Resveratrol 91-102 chemokine (C-C motif) receptor 6 Mus musculus 0-4 21340626-8 2011 CCR6 abundance on IL-17-producing cells and CD11b(+)F4/80(hi) macrophages was inhibited by resveratrol treatment. Resveratrol 91-102 interleukin 17A Mus musculus 18-23 21340626-9 2011 Interestingly, CCR6(+) IL-17-producing cells and CD11b(+)F4/80(hi) macrophages accumulated in the spleens and pancreatic lymph nodes, but their presence in the pancreas was reduced, suggesting that resveratrol blocks their migration from peripheral lymphoid organs to the pancreas. Resveratrol 198-209 chemokine (C-C motif) receptor 6 Mus musculus 15-19 21340626-12 2011 CONCLUSIONS/INTERPRETATION: Inhibition of CCR6-mediated migration of inflammatory cells by resveratrol may provide a powerful approach for treatment of type 1 diabetes and possibly of other inflammatory diseases. Resveratrol 91-102 chemokine (C-C motif) receptor 6 Mus musculus 42-46 21541654-11 2011 Altogether, the present data demonstrate that resveratrol (1) induces apoptosis of tumoral cardiac HL1-NB cells, (2) does not induce cell death on normal cardiomyocytes, and (3) prevents norepinephrine-induced apoptosis on normal cardiomyocytes. Resveratrol 46-57 asialoglycoprotein receptor 1 Mus musculus 99-102 21192278-0 2011 Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. Resveratrol 81-92 heme oxygenase 1 Rattus norvegicus 61-77 21192278-3 2011 Thus, we set out to determine whether resveratrol-mediated estrogen receptor-dependent p38 mitogen-activated protein kinase (MAPK)/heme oxygenase 1 activation protects the intestine after trauma-hemorrhage. Resveratrol 38-49 heme oxygenase 1 Rattus norvegicus 131-147 21192278-12 2011 Resveratrol treatment also increased intestinal heme oxygenase 1 expression as compared with vehicle-treated trauma-hemorrhaged rats. Resveratrol 0-11 heme oxygenase 1 Rattus norvegicus 48-64 21192278-15 2011 These results suggest that estrogen receptor-dependent upregulation of the p38 MAPK/heme oxygenase 1 pathway plays a critical role in mediating the salutary effects of resveratrol on shock-induced intestinal injury. Resveratrol 168-179 heme oxygenase 1 Rattus norvegicus 84-100 21282584-9 2011 The reduction of vascular lesions in resveratrol-treated Vldlr(-/-) mice is associated with the suppression of retinal Vegf transcription. Resveratrol 37-48 vascular endothelial growth factor A Mus musculus 119-123 21282584-12 2011 CONCLUSIONS: Oral administration of resveratrol is protective against retinal neovascular lesions in Vldlr(-/-) mice by inhibiting Vegf expression and angiogenic activation of retinal endothelial cells. Resveratrol 36-47 vascular endothelial growth factor A Mus musculus 131-135 21544240-7 2011 Like the mTOR/S6K1 inhibitor rapamycin, resveratrol inhibited S6K1 signalling, resulting in decreased superoxide generation and enhanced NO levels in the senescent cells. Resveratrol 40-51 mechanistic target of rapamycin kinase Rattus norvegicus 9-13 21277951-6 2011 Our findings reveal a strong link between resveratrol-dependent SIRT1 signaling and hippocampal plasticity in the mammalian brain. Resveratrol 42-53 sirtuin 1 Homo sapiens 64-69 21483037-0 2011 Resveratrol-activated SIRT1 in liver and pancreatic beta-cells: a Janus head looking to the same direction of metabolic homeostasis. Resveratrol 0-11 sirtuin 1 Homo sapiens 22-27 21483037-3 2011 SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance. Resveratrol 31-42 sirtuin 1 Homo sapiens 0-5 21483037-4 2011 The beneficial effects of resveratrol mediated by SIRT1 activation can be contributed by different organs. Resveratrol 26-37 sirtuin 1 Homo sapiens 50-55 21483037-5 2011 Among them, the liver and pancreatic beta-cells have been shown to be responsive to resveratrol in a SIRT1-dependent manner. Resveratrol 84-95 sirtuin 1 Homo sapiens 101-106 21612158-8 2011 Resveratrol diminished the translocation or activation of IRF-3 at 90min, c-Jun, a subunit of AP-1, and STAT-1 at 120 min, and p50, a subunit of NF-KB, at 60 and 90 min. Resveratrol 0-11 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 74-79 21224254-0 2011 Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol. Resveratrol 129-140 palmitoyl-protein thioesterase 1 Mus musculus 92-96 21224254-9 2011 Most importantly, resveratrol (RSV), an antioxidant polyphenol, elevated the NAD(+)/NADH ratio, levels of ATP, p-AMPK, PGC-1alpha and SIRT1 while decreasing the level of p-S6K1 in both INCL fibroblasts and in Ppt1-KO mice, which showed a modest increase in lifespan. Resveratrol 18-29 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 172-176 21224254-9 2011 Most importantly, resveratrol (RSV), an antioxidant polyphenol, elevated the NAD(+)/NADH ratio, levels of ATP, p-AMPK, PGC-1alpha and SIRT1 while decreasing the level of p-S6K1 in both INCL fibroblasts and in Ppt1-KO mice, which showed a modest increase in lifespan. Resveratrol 18-29 palmitoyl-protein thioesterase 1 Mus musculus 209-213 21224254-9 2011 Most importantly, resveratrol (RSV), an antioxidant polyphenol, elevated the NAD(+)/NADH ratio, levels of ATP, p-AMPK, PGC-1alpha and SIRT1 while decreasing the level of p-S6K1 in both INCL fibroblasts and in Ppt1-KO mice, which showed a modest increase in lifespan. Resveratrol 31-34 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 172-176 21224254-9 2011 Most importantly, resveratrol (RSV), an antioxidant polyphenol, elevated the NAD(+)/NADH ratio, levels of ATP, p-AMPK, PGC-1alpha and SIRT1 while decreasing the level of p-S6K1 in both INCL fibroblasts and in Ppt1-KO mice, which showed a modest increase in lifespan. Resveratrol 31-34 palmitoyl-protein thioesterase 1 Mus musculus 209-213 21224254-10 2011 Our results show that disruption of adaptive energy metabolism and increased levels of p-S6K1 are contributing factors in INCL pathogenesis and provide the proof of principle that small molecules such as RSV, which alleviate these abnormalities, may have therapeutic potential. Resveratrol 204-207 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 89-93 21238464-0 2011 Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells. Resveratrol 0-11 sirtuin 1 Homo sapiens 90-95 21238464-1 2011 AIMS: Resveratrol, a silent information regulator 1 (SIRT1) activator, has been reported to act as an antioxidant contained in red wine and prevent the development of cardiovascular diseases. Resveratrol 6-17 sirtuin 1 Homo sapiens 21-51 21238464-1 2011 AIMS: Resveratrol, a silent information regulator 1 (SIRT1) activator, has been reported to act as an antioxidant contained in red wine and prevent the development of cardiovascular diseases. Resveratrol 6-17 sirtuin 1 Homo sapiens 53-58 21238464-5 2011 Western blot analysis and RT-PCR assay were used to determine the effect of resveratrol on the expression level of MMP-9, MAPK and SIRT1 proteins and genes, respectively. Resveratrol 76-87 matrix metallopeptidase 9 Homo sapiens 115-120 21238464-5 2011 Western blot analysis and RT-PCR assay were used to determine the effect of resveratrol on the expression level of MMP-9, MAPK and SIRT1 proteins and genes, respectively. Resveratrol 76-87 sirtuin 1 Homo sapiens 131-136 21238464-7 2011 Furthermore, it was found that treatment with resveratrol decreased the level of MMP-9 expression via down-regulation of p-ERK, c-fos and p65. Resveratrol 46-57 matrix metallopeptidase 9 Homo sapiens 81-86 21238464-7 2011 Furthermore, it was found that treatment with resveratrol decreased the level of MMP-9 expression via down-regulation of p-ERK, c-fos and p65. Resveratrol 46-57 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 128-133 21238464-8 2011 In addition, the level of SIRT1 gene expression was also enhanced by treatment of resveratrol alone but the level of MMP-9 gene expression was decreased. Resveratrol 82-93 sirtuin 1 Homo sapiens 26-31 21238464-9 2011 SIGNIFICANCE: These results suggest that the activation of SIRT1 in the presence of resveratrol especially inhibits the expression of MMP-9 in HT1080 cells, providing evidence that resveratrol can be a potential candidate for chemoprevention of cancer. Resveratrol 84-95 sirtuin 1 Homo sapiens 59-64 21238464-9 2011 SIGNIFICANCE: These results suggest that the activation of SIRT1 in the presence of resveratrol especially inhibits the expression of MMP-9 in HT1080 cells, providing evidence that resveratrol can be a potential candidate for chemoprevention of cancer. Resveratrol 84-95 matrix metallopeptidase 9 Homo sapiens 134-139 21238464-9 2011 SIGNIFICANCE: These results suggest that the activation of SIRT1 in the presence of resveratrol especially inhibits the expression of MMP-9 in HT1080 cells, providing evidence that resveratrol can be a potential candidate for chemoprevention of cancer. Resveratrol 181-192 sirtuin 1 Homo sapiens 59-64 21238464-9 2011 SIGNIFICANCE: These results suggest that the activation of SIRT1 in the presence of resveratrol especially inhibits the expression of MMP-9 in HT1080 cells, providing evidence that resveratrol can be a potential candidate for chemoprevention of cancer. Resveratrol 181-192 matrix metallopeptidase 9 Homo sapiens 134-139 21196497-5 2011 The SIRT1-selective inhibitors EX-527 and nicotinamide stimulated Nrf2-dependent gene transcription, whereas resveratrol, a putative activator of SIRT1, was inhibitory, mimicking the effect of SIRT1. Resveratrol 109-120 sirtuin 1 Homo sapiens 4-9 21196497-5 2011 The SIRT1-selective inhibitors EX-527 and nicotinamide stimulated Nrf2-dependent gene transcription, whereas resveratrol, a putative activator of SIRT1, was inhibitory, mimicking the effect of SIRT1. Resveratrol 109-120 sirtuin 1 Homo sapiens 146-151 21196497-5 2011 The SIRT1-selective inhibitors EX-527 and nicotinamide stimulated Nrf2-dependent gene transcription, whereas resveratrol, a putative activator of SIRT1, was inhibitory, mimicking the effect of SIRT1. Resveratrol 109-120 sirtuin 1 Homo sapiens 146-151 21235286-7 2011 Resveratrol and piceatannol restored DDAH activity even in the presence of splitomicin, a specific inhibitor of Sirtuin 1. Resveratrol 0-11 sirtuin 1 Bos taurus 112-121 21207142-3 2011 As assessed by zymography and RT-PCR, RSV and Oliplus, but not QRC and GTE, dose-dependently inhibited the LPS-induced levels and mRNA expression of MMP-2 and MMP-9. Resveratrol 38-41 matrix metallopeptidase 9 Rattus norvegicus 159-164 21114990-8 2011 Plasma levels of VEGF were significantly reduced in groups treated with resveratrol or curcumin and their combination with carboplatin on day 7 post-inoculation. Resveratrol 72-83 vascular endothelial growth factor A Mus musculus 17-21 20714724-7 2011 However, the rates of apoptosis caused by resveratrol combined with purine analogues were independent of ZAP-70 and CD38 expression and the clinical state of the disease; they were only dependent on the presence of high-risk cytogenetic abnormalities. Resveratrol 42-53 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 105-111 21204775-2 2011 Resveratrol (Rsv), a polyphenol that extends the lifespan of diverse species is an activator of SIRT1, a NAD(+) dependent deacetylating enzyme in mammalian cells. Resveratrol 0-11 sirtuin 1 Homo sapiens 96-101 21204775-2 2011 Resveratrol (Rsv), a polyphenol that extends the lifespan of diverse species is an activator of SIRT1, a NAD(+) dependent deacetylating enzyme in mammalian cells. Resveratrol 13-16 sirtuin 1 Homo sapiens 96-101 21878744-9 2011 This effect of resveratrol was independent of nuclear factor (NF)-kappaB and sirtuin 1, but was abrogated in the presence of Rho kinase inhibitors. Resveratrol 15-26 sirtuin 1 Homo sapiens 77-86 20720562-0 2011 Resveratrol targets transforming growth factor-beta2 signaling to block UV-induced tumor progression. Resveratrol 0-11 transforming growth factor beta 2 Homo sapiens 20-52 21845215-5 2011 Recently, resveratrol (trans-3,4",5-trihydroxystilbene), a natural polyphenol with antioxidant, anti-inflammatory, and anticancer properties, currently at the stage of preclinical studies for human cancer prevention, has been shown to induce the expression of miR-663, a tumor-suppressor and anti-inflammatory microRNA, while downregulating miR-155 and miR-21. Resveratrol 10-21 microRNA 155 Homo sapiens 341-348 21845215-6 2011 In this paper we will discuss how the use of resveratrol in therapeutics may benefit from the preanalyses on the status of expression of miR-155 or miR-21 as well as of TGFbeta1. Resveratrol 45-56 microRNA 155 Homo sapiens 137-144 22220203-0 2011 Resveratrol protects rats from Abeta-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation. Resveratrol 0-11 amyloid beta precursor protein Rattus norvegicus 31-36 22220203-3 2011 The present study is aimed to elucidate the cellular effect of resveratrol, a natural phytoestrogen with neuroprotective activities, on Abeta-induced hippocampal neuron loss and memory impairment. Resveratrol 63-74 amyloid beta precursor protein Rattus norvegicus 136-141 22220203-5 2011 By combining the treatment with Abeta, resveratrol was able to confer a significant improvement in spatial memory, and protect animals from Abeta-induced neurotoxicity. Resveratrol 39-50 amyloid beta precursor protein Rattus norvegicus 32-37 22220203-5 2011 By combining the treatment with Abeta, resveratrol was able to confer a significant improvement in spatial memory, and protect animals from Abeta-induced neurotoxicity. Resveratrol 39-50 amyloid beta precursor protein Rattus norvegicus 140-145 22220203-6 2011 These neurological protection effects of resveratrol were associated with a reduction in the cellular levels of iNOS and lipid peroxidation and an increase in the production of HO-1. Resveratrol 41-52 heme oxygenase 1 Rattus norvegicus 177-181 22174926-5 2011 We found that 20 microg/ml and 50 microg/ml of resveratrol affected exon inclusion of SRp20 and SMN2 pre-mRNAs, but not CD44v5 or tau pre-mRNAs. Resveratrol 47-58 serine and arginine rich splicing factor 3 Homo sapiens 86-91 22174926-8 2011 By means of siRNA-mediated knockdown we depleted cells of SIRT1, regarded as a major target of resveratrol, and showed that the effect on splicing was not dependent on SIRT1. Resveratrol 95-106 sirtuin 1 Homo sapiens 58-63 22205977-6 2011 While Idebenone acts by downregulating the integrated stress response, Resveratrol acts by attenuating apoptosis at the level of Bax. Resveratrol 71-82 BCL2-associated X protein Mus musculus 129-132 21673955-6 2011 RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice. Resveratrol 0-3 glucagon-like peptide 1 receptor Mus musculus 51-65 21673955-6 2011 RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice. Resveratrol 0-3 glucagon-like peptide 1 receptor Mus musculus 67-72 21209944-3 2010 Therefore, the present study was designed to validate whether resveratrol can enhance the apoptosis-inducing potential of TRAIL in a xenograft model of prostate cancer. Resveratrol 62-73 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 122-127 21209944-6 2010 In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and p27(/KIP1), and inhibited the expression of Bcl-2 and cyclin D1. Resveratrol 23-34 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 66-71 21209944-6 2010 In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and p27(/KIP1), and inhibited the expression of Bcl-2 and cyclin D1. Resveratrol 23-34 BCL2-associated X protein Mus musculus 94-97 21209944-6 2010 In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and p27(/KIP1), and inhibited the expression of Bcl-2 and cyclin D1. Resveratrol 23-34 cyclin-dependent kinase inhibitor 1B Mus musculus 102-105 21209944-6 2010 In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and p27(/KIP1), and inhibited the expression of Bcl-2 and cyclin D1. Resveratrol 23-34 cyclin-dependent kinase inhibitor 1B Mus musculus 107-111 21209944-6 2010 In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and p27(/KIP1), and inhibited the expression of Bcl-2 and cyclin D1. Resveratrol 23-34 cyclin D1 Mus musculus 156-165 21209944-7 2010 Treatment of mice with resveratrol and TRAIL alone inhibited angiogenesis (as demonstrated by reduced number of blood vessels, and VEGF and VEGFR2 positive cells) and markers of metastasis (MMP-2 and MMP-9). Resveratrol 23-34 vascular endothelial growth factor A Mus musculus 131-135 21209944-7 2010 Treatment of mice with resveratrol and TRAIL alone inhibited angiogenesis (as demonstrated by reduced number of blood vessels, and VEGF and VEGFR2 positive cells) and markers of metastasis (MMP-2 and MMP-9). Resveratrol 23-34 matrix metallopeptidase 2 Mus musculus 190-195 21209944-9 2010 Furthermore, resveratrol inhibited the cytoplasmic phosphorylation of FKHRL1 resulting in its enhanced activation as demonstrated by increased DNA binding activity. Resveratrol 13-24 forkhead box O3 Mus musculus 70-76 21209944-10 2010 CONCLUSIONS/SIGNIFICANCE: These data suggest that resveratrol can enhance the apoptosis-inducing potential of TRAIL by activating FKHRL1 and its target genes. Resveratrol 50-61 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 110-115 21209944-10 2010 CONCLUSIONS/SIGNIFICANCE: These data suggest that resveratrol can enhance the apoptosis-inducing potential of TRAIL by activating FKHRL1 and its target genes. Resveratrol 50-61 forkhead box O3 Mus musculus 130-136 21209944-11 2010 The ability of resveratrol to inhibit tumor growth, metastasis and angiogenesis, and enhance the therapeutic potential of TRAIL suggests that resveratrol alone or in combination with TRAIL can be used for the management of prostate cancer. Resveratrol 142-153 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 122-127 21179458-15 2010 Inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/KIP1 and apoptosis, and inhibition of cyclin D1 by resveratrol. Resveratrol 58-69 major histocompatibility complex, class II, DR beta 4 Homo sapiens 106-109 20826722-0 2010 Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol. Resveratrol 77-88 Fanconi anemia, complementation group D2 Mus musculus 0-6 20826722-6 2010 Treatment with Sirt1-mimetic and the antioxidant drug, resveratrol, maintained Fancd2(-/-) KSL cells in quiescence, improved the marrow microenvironment, partially corrected the abnormal cell cycle status, and significantly improved the spleen colony-forming capacity of Fancd2(-/-) bone marrow cells. Resveratrol 55-66 Fanconi anemia, complementation group D2 Mus musculus 79-85 20826722-6 2010 Treatment with Sirt1-mimetic and the antioxidant drug, resveratrol, maintained Fancd2(-/-) KSL cells in quiescence, improved the marrow microenvironment, partially corrected the abnormal cell cycle status, and significantly improved the spleen colony-forming capacity of Fancd2(-/-) bone marrow cells. Resveratrol 55-66 Fanconi anemia, complementation group D2 Mus musculus 271-277 20861279-7 2010 Resveratrol increased gastrocnemius catalase activity, MnSOD activity, and MnSOD protein content following HLS. Resveratrol 0-11 superoxide dismutase 2 Rattus norvegicus 55-60 20861279-7 2010 Resveratrol increased gastrocnemius catalase activity, MnSOD activity, and MnSOD protein content following HLS. Resveratrol 0-11 superoxide dismutase 2 Rattus norvegicus 75-80 21368872-8 2010 Pharmacological manipulation of Lys310 acetylation by the sirtuin 1 activator resveratrol repressed the activity of the Bim promoter and reduced the neuronal cell loss. Resveratrol 78-89 BCL2-like 11 (apoptosis facilitator) Mus musculus 120-123 20823772-4 2010 RECENT FINDINGS: Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome. Resveratrol 93-104 sirtuin 1 Homo sapiens 82-91 20823772-4 2010 RECENT FINDINGS: Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome. Resveratrol 93-104 sirtuin 1 Homo sapiens 221-230 20878097-6 2010 The results showed that resveratrol up-regulated levels of cyclin-dependent kinase inhibitor p57, egr-1, forkhead box A2 and c-jun in HAECs, and elevated expression of cathepsin D, ICAM-1, c-jun and patched 1 in HPAECs. Resveratrol 24-35 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 125-130 20878097-6 2010 The results showed that resveratrol up-regulated levels of cyclin-dependent kinase inhibitor p57, egr-1, forkhead box A2 and c-jun in HAECs, and elevated expression of cathepsin D, ICAM-1, c-jun and patched 1 in HPAECs. Resveratrol 24-35 intercellular adhesion molecule 1 Homo sapiens 181-187 20878097-6 2010 The results showed that resveratrol up-regulated levels of cyclin-dependent kinase inhibitor p57, egr-1, forkhead box A2 and c-jun in HAECs, and elevated expression of cathepsin D, ICAM-1, c-jun and patched 1 in HPAECs. Resveratrol 24-35 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 189-194 20878097-7 2010 In addition, treatment by resveratrol also resulted in attenuated expression of bcl-xl, fibronectin-1, HIP, mdm2, PIG3 and WSB1/SWIP-1 in HAECs, and CDX1, engrailed homolog 1, FASN, fibronectin-1, forkhead box A2, Hoxa-1, hsp27, PIG3, ELAM-1/E-selectin and WSB1/SWIP-1 in HPAECs. Resveratrol 26-37 MDM2 proto-oncogene Homo sapiens 108-112 20878097-7 2010 In addition, treatment by resveratrol also resulted in attenuated expression of bcl-xl, fibronectin-1, HIP, mdm2, PIG3 and WSB1/SWIP-1 in HAECs, and CDX1, engrailed homolog 1, FASN, fibronectin-1, forkhead box A2, Hoxa-1, hsp27, PIG3, ELAM-1/E-selectin and WSB1/SWIP-1 in HPAECs. Resveratrol 26-37 engrailed homeobox 1 Homo sapiens 155-174 20878097-7 2010 In addition, treatment by resveratrol also resulted in attenuated expression of bcl-xl, fibronectin-1, HIP, mdm2, PIG3 and WSB1/SWIP-1 in HAECs, and CDX1, engrailed homolog 1, FASN, fibronectin-1, forkhead box A2, Hoxa-1, hsp27, PIG3, ELAM-1/E-selectin and WSB1/SWIP-1 in HPAECs. Resveratrol 26-37 fatty acid synthase Homo sapiens 176-180 21031621-8 2010 Simultaneously, resveratrol regulated the expression of the antiapoptotic proteins Bcl-2, Bcl-xL and XIAP and the proapoptotic protein Bax. Resveratrol 16-27 X-linked inhibitor of apoptosis Homo sapiens 101-105 20426787-7 2010 Moreover, treatment with a SIRT1 activator, resveratrol, significantly suppressed IL-1beta-mediated induction of MMP-1, which was attenuated by pretreatment with EX-527. Resveratrol 44-55 sirtuin 1 Homo sapiens 27-32 20832999-9 2010 Another reported non-selective PKD inhibitor, resveratrol stimulated differentiation and inhibited proliferation. Resveratrol 46-57 protein kinase D1 Homo sapiens 31-34 20832999-11 2010 CONCLUSION: Our results support the idea that relatively selective PKD inhibitors, such as Go6976, H89 and resveratrol, might be useful for preventing/treating epidermal tumorigenesis without affecting keratinocyte differentiation. Resveratrol 107-118 protein kinase D1 Homo sapiens 67-70 20486211-4 2010 In cultured vascular smooth muscle cells, trans-resveratrol inhibited platelet-derived growth factor-stimulated DNA synthesis and cell proliferation with down-regulation of cyclin D and pRB. Resveratrol 42-59 RB transcriptional corepressor 1 Mus musculus 186-189 19897059-5 2010 Many of these effects are consistent with modulation of SIRT1 targets, such as PGC1alpha and NFkappaB, however, resveratrol can also activate AMPK, inhibit cyclooxygenases, and influence a variety of other enzymes. Resveratrol 112-123 sirtuin 1 Homo sapiens 56-61 19897059-7 2010 At present, further studies are needed to more directly test the role of SIRT1 in mediating beneficial effects of resveratrol, to evaluate other strategies for SIRT1 activation, and to confirm the specific targets of SIRT1 that are relevant in vivo. Resveratrol 114-125 sirtuin 1 Homo sapiens 73-78 21090107-6 2010 The expression of sirt1, caspase-3, and bax was up-regulated markedly in response to resveratrol; in contrast, apoptotic inhibitor bcl-2, p53, NF-kappaB down-regulated. Resveratrol 85-96 sirtuin 1 Homo sapiens 18-23 21090107-7 2010 We further proved fact that resveratrol can specifically promote the activity of sirt1; moreover, activated sirt1 modulates the activity of caspase-3 and bcl-2 family, involving in transcriptional regulation of p53 and NF-kappaB through antagonizing factor-induced acetylation. Resveratrol 28-39 sirtuin 1 Homo sapiens 81-86 21090107-7 2010 We further proved fact that resveratrol can specifically promote the activity of sirt1; moreover, activated sirt1 modulates the activity of caspase-3 and bcl-2 family, involving in transcriptional regulation of p53 and NF-kappaB through antagonizing factor-induced acetylation. Resveratrol 28-39 sirtuin 1 Homo sapiens 108-113 21090107-8 2010 Taken together, our data established resveratrol as new regulator in porcine primary preadipocyte apoptosis via activating the expression of sirt1, modulating activity of apoptotic-associated factor. Resveratrol 37-48 sirtuin 1 Homo sapiens 141-146 19908231-7 2010 Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF. Resveratrol 0-11 matrix metallopeptidase 9 Homo sapiens 228-233 19908231-10 2010 As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin. Resveratrol 32-43 intercellular adhesion molecule 1 Homo sapiens 121-127 19908231-10 2010 As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin. Resveratrol 32-43 matrix metallopeptidase 9 Homo sapiens 129-134 20418481-5 2010 Accordingly, resveratrol significantly upregulates the expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1, gamma-glutamylcysteine synthetase, and heme oxygenase-1. Resveratrol 13-24 NAD(P)H dehydrogenase, quinone 1 Mus musculus 91-123 20418481-9 2010 In HFD-fed Nrf2(+/+) mice, resveratrol treatment attenuates oxidative stress (assessed by the Amplex red assay), improves acetylcholine-induced vasodilation, and inhibits apoptosis (assessed by measuring caspase-3 activity and DNA fragmentation) in branches of the femoral artery. Resveratrol 27-38 caspase 3 Mus musculus 204-213 20463039-0 2010 Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Resveratrol 0-11 sirtuin 1 Homo sapiens 63-68 20463039-2 2010 This effect of caloric restriction can be mimicked by resveratrol, a natural plant product present in grapes and red wine, which is known as a potent activator of sirtuin 1 [silent mating type information regulation 2 homolog 1 (Sirt1)]. Resveratrol 54-65 sirtuin 1 Homo sapiens 163-227 20463039-2 2010 This effect of caloric restriction can be mimicked by resveratrol, a natural plant product present in grapes and red wine, which is known as a potent activator of sirtuin 1 [silent mating type information regulation 2 homolog 1 (Sirt1)]. Resveratrol 54-65 sirtuin 1 Homo sapiens 229-234 20463039-4 2010 We sought to identify the effects of resveratrol on fat cell biology and to elucidate whether Sirt1 is involved in resveratrol-mediated changes. Resveratrol 115-126 sirtuin 1 Homo sapiens 94-99 20463039-6 2010 Sirt1-deficient human preadipocytes were generated by using a lentiviral small hairpin RNA system to study the role of Sirt1 in resveratrol-mediated changes. Resveratrol 128-139 sirtuin 1 Homo sapiens 0-5 20463039-7 2010 RESULTS: Resveratrol inhibited preadipocyte proliferation and adipogenic differentiation in a Sirt1-dependent manner. Resveratrol 9-20 sirtuin 1 Homo sapiens 94-99 20463039-11 2010 Sirt1 was only partially responsible for the regulation of resveratrol-mediated changes in adipokine secretion. Resveratrol 59-70 sirtuin 1 Homo sapiens 0-5 20458181-0 2010 AMPK- and p62/SQSTM1-dependent autophagy mediate resveratrol-induced cell death in chronic myelogenous leukemia. Resveratrol 49-60 sequestosome 1 Homo sapiens 10-13 20458181-0 2010 AMPK- and p62/SQSTM1-dependent autophagy mediate resveratrol-induced cell death in chronic myelogenous leukemia. Resveratrol 49-60 sequestosome 1 Homo sapiens 14-20 20458181-3 2010 Our recent data reveals that RSV triggered autophagic cell death (ACD) in Chronic Myelogenous Leukemia (CML) cells, via both AMPK activation and JNK-mediated p62/SQSTM1 expression. Resveratrol 29-32 sequestosome 1 Homo sapiens 158-161 20458181-3 2010 Our recent data reveals that RSV triggered autophagic cell death (ACD) in Chronic Myelogenous Leukemia (CML) cells, via both AMPK activation and JNK-mediated p62/SQSTM1 expression. Resveratrol 29-32 sequestosome 1 Homo sapiens 162-168 20458181-4 2010 Here we discuss how Resveratrol can mediate ACD in CML cells and the possibility of utilizing the AMPK/mTOR and JNK/p62 pathways via Resveratrol to combat CML and other hematopoietic malignancies. Resveratrol 133-144 sequestosome 1 Homo sapiens 116-119 20466593-8 2010 Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene. Resveratrol 34-45 aryl hydrocarbon receptor Rattus norvegicus 10-13 20466593-8 2010 Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene. Resveratrol 34-45 aryl hydrocarbon receptor Rattus norvegicus 142-145 20169165-5 2010 The SIRT1 activator resveratrol reduces, whereas SIRT1 inhibitor nicotinamide enhances mTOR activity in a SIRT1 dependent manner. Resveratrol 20-31 sirtuin 1 Homo sapiens 4-9 19928762-8 2010 Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. Resveratrol 55-66 sirtuin 1 Homo sapiens 121-135 19928762-8 2010 Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. Resveratrol 55-66 sirtuin 1 Homo sapiens 137-142 19928762-9 2010 To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. Resveratrol 62-73 sirtuin 1 Homo sapiens 100-105 19928762-11 2010 Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases. Resveratrol 34-45 sirtuin 1 Homo sapiens 10-15 20090934-0 2010 Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70. Resveratrol 41-52 heat shock protein family A (Hsp70) member 4 Homo sapiens 130-135 20090934-1 2010 BACKGROUND: Resveratrol is known to downregulate the high endogenous level of Heat shock protein 70 (Hsp70) in Chronic Myelogenous Leukemia (CML) K562 cells and induce apoptosis. Resveratrol 12-23 heat shock protein family A (Hsp70) member 4 Homo sapiens 78-99 20090934-1 2010 BACKGROUND: Resveratrol is known to downregulate the high endogenous level of Heat shock protein 70 (Hsp70) in Chronic Myelogenous Leukemia (CML) K562 cells and induce apoptosis. Resveratrol 12-23 heat shock protein family A (Hsp70) member 4 Homo sapiens 101-106 20090934-10 2010 Therefore, increase in ERK1/2 activity by Resveratrol provided another negative influence on Hsp70 levels through negative regulation of HSF1 activity. Resveratrol 42-53 heat shock protein family A (Hsp70) member 4 Homo sapiens 93-98 20090934-15 2010 CONCLUSION/SIGNIFICANCE: Thus our study comprehensively illustrates that Resveratrol acts downstream of Bcr-Abl and inhibits Akt activity but stimulates ERK1/2 activity. Resveratrol 73-84 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 104-111 20090934-17 2010 Additionally, Resveratrol can be used in combination with chemotherapeutic agents such as 17AAG, an Hsp90 inhibitor reported to induce Hsp70 and hence compromise its chemotherapeutic potential. Resveratrol 14-25 heat shock protein family A (Hsp70) member 4 Homo sapiens 135-140 20825639-8 2010 Such effects of resveratrol were likely mediated through inhibiting IKK-IkappaBalpha-NF-kappaB and JNK/ERK-AP-1 signaling pathways induced by AGEs. Resveratrol 16-27 mitogen-activated protein kinase 8 Sus scrofa 99-102 19765649-6 2010 Resveratrol inhibited high glucose-induced changes in association of eIF4E with eIF4G, phosphorylation of eIF4E, eEF2, eEF2 kinase and, p70S6 kinase, indicating that it affects important events in both initiation and elongation phases of mRNA translation. Resveratrol 0-11 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 80-85 20299793-0 2010 Prominent chemopreventive and chemoenhancing effects for resveratrol: unraveling molecular targets and the role of C-reactive protein. Resveratrol 57-68 C-reactive protein, pentraxin-related Mus musculus 115-133 20299793-5 2010 RSVL (20 or 40 mg/kg) elicited significant, dose-dependent reductions in tumor size (58 and 78%, respectively), as well as in LC (normalized), CRP (down to 2 fold), TNF-alpha (down to near control levels) and MDA levels (normalized). Resveratrol 0-4 C-reactive protein, pentraxin-related Mus musculus 143-146 20061622-3 2010 The most widely investigated and best known sirtuin is SIRT1, which can be activated by the natural phytocompound resveratrol and plays a role in several physiologic (embryogenesis, glucose metabolism, apoptosis, autophagy, chromatin integrity, and transcriptional state) and pathologic (diabetes, cancer, cardiovascular disorders, and neurodegeneration) conditions. Resveratrol 114-125 sirtuin 1 Homo sapiens 55-60 19934257-7 2010 Activation of SIRT1 with resveratrol promotes binding of APE1 to the BER protein X-ray cross-complementing-1 (XRCC1), while inhibition of SIRT1 with nicotinamide (NAM) decreases this interaction. Resveratrol 25-36 sirtuin 1 Homo sapiens 14-19 19934257-7 2010 Activation of SIRT1 with resveratrol promotes binding of APE1 to the BER protein X-ray cross-complementing-1 (XRCC1), while inhibition of SIRT1 with nicotinamide (NAM) decreases this interaction. Resveratrol 25-36 X-ray repair cross complementing 1 Homo sapiens 81-108 19934257-7 2010 Activation of SIRT1 with resveratrol promotes binding of APE1 to the BER protein X-ray cross-complementing-1 (XRCC1), while inhibition of SIRT1 with nicotinamide (NAM) decreases this interaction. Resveratrol 25-36 X-ray repair cross complementing 1 Homo sapiens 110-115 19934257-9 2010 Finally, resveratrol increases APE activity in XRCC1-associated protein complexes, while NAM or knockdown of SIRT1 suppresses this DNA repair activity. Resveratrol 9-20 X-ray repair cross complementing 1 Homo sapiens 47-52 19934264-6 2010 The suppression was dependent on the deacetylase activity of SIRT1 and was enhanced by a SIRT1 activator, resveratrol. Resveratrol 106-117 sirtuin 1 Homo sapiens 61-66 19934264-6 2010 The suppression was dependent on the deacetylase activity of SIRT1 and was enhanced by a SIRT1 activator, resveratrol. Resveratrol 106-117 sirtuin 1 Homo sapiens 89-94 19956893-0 2010 Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells. Resveratrol 0-11 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 87-94 19956893-2 2010 Human multidrug-resistant SPC-A-1/CDDP cells were treated with resveratrol at a concentration of 25, 50, or 100 microM in in vitro studies and nude mice were implanted with multidrug-resistant SPC-A-1/and fed a special diet that included resveratrol at a dose of either 1 g/kg/day or 3 g/kg/day in in vivo studies. Resveratrol 63-74 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 26-33 19956893-5 2010 Resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, arrested the cell cycle phase between G0-G1 and S phase or at the G2/M phase, decreased the IC50 values of multiple chemotherapeutic drugs, and showed anti-tumour effects in nude mice that had been implanted with SPC-A-1/CDDP cells. Resveratrol 0-11 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 57-64 19956893-5 2010 Resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, arrested the cell cycle phase between G0-G1 and S phase or at the G2/M phase, decreased the IC50 values of multiple chemotherapeutic drugs, and showed anti-tumour effects in nude mice that had been implanted with SPC-A-1/CDDP cells. Resveratrol 0-11 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 309-316 19956893-6 2010 In additional, resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner. Resveratrol 15-26 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 57-64 19956893-7 2010 Expression of survivin in SPC-A-1/CDDP cells decreased after they were treated with all concentrations of resveratrol and resveratrol was also found to have a dose-dependent effect on survivin expression. Resveratrol 106-117 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 26-33 19956893-7 2010 Expression of survivin in SPC-A-1/CDDP cells decreased after they were treated with all concentrations of resveratrol and resveratrol was also found to have a dose-dependent effect on survivin expression. Resveratrol 122-133 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 26-33 19956893-8 2010 Resveratrol can induce apoptosis in multidrug-resistant human NSCLC SPC-A-1/CDDP cells by down-regulating the expression of survivin. Resveratrol 0-11 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 68-75 21113404-7 2010 Under hypoxia, Resveratrol induced SIRT1, RXR-alpha, PPAR-alpha mRNA, and PPAR-gamma and UCP-2 protein. Resveratrol 15-26 sirtuin 1 Homo sapiens 35-40 21113404-7 2010 Under hypoxia, Resveratrol induced SIRT1, RXR-alpha, PPAR-alpha mRNA, and PPAR-gamma and UCP-2 protein. Resveratrol 15-26 retinoid X receptor alpha Homo sapiens 42-51 21062536-6 2010 Resveratrol induced a significant increase in manganese superoxide dismutase activity (160 +- 11.78%; P < 0.0001) and a decrease in ROS generation (P < 0.05 to P < 0.0001). Resveratrol 0-11 superoxide dismutase 2 Rattus norvegicus 46-76 22219708-6 2010 Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. Resveratrol 67-78 sirtuin 1 Homo sapiens 14-19 22219708-9 2010 Importantly, the anti-oxidant effects of resveratrol in H(2)O(2)-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1). Resveratrol 41-52 sirtuin 1 Homo sapiens 137-142 22219708-9 2010 Importantly, the anti-oxidant effects of resveratrol in H(2)O(2)-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1). Resveratrol 41-52 sirtuin 1 Homo sapiens 158-163 22219708-11 2010 Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression. Resveratrol 0-11 sirtuin 1 Homo sapiens 86-91 20157579-6 2009 Genetic and functional studies indicate that spermidine inhibits histone acetylases, while resveratrol activates the histone deacetylase Sirtuin 1 to confer cytoprotection/longevity. Resveratrol 91-102 sirtuin 1 Homo sapiens 137-146 27713233-6 2009 By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFkappabeta. Resveratrol 25-36 sirtuin 1 Homo sapiens 14-23 19568959-3 2009 The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. Resveratrol 146-157 sirtuin 1 Homo sapiens 61-66 19552907-6 2009 Respect to its effect on cholesterol homeostasis, resveratrol also enhanced apoA-1-mediated cholesterol efflux (r(2)=0.907, p<0.05, linear regression) by up-regulating ABCA-1 receptors, and reduced cholesterol influx or uptake in J774 macrophages (r(2)=0.89, p<0.05, linear regression). Resveratrol 50-61 ATP binding cassette subfamily A member 1 Homo sapiens 171-177