PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9852385-3	1999	Multiple regression analysis confirmed that the significant independent determinants of NAG/creatinine ratio were age, parity, gestation and fasting state.	Creatinine	92-102	N-acetyl-alpha-glucosaminidase	Homo sapiens	88-91
10075598-13	1999	The mean serum creatinine was 1.1+/-0.5 mg/dl, and the corresponding calculated creatinine clearance was 88+/-25 ml/min/1.73 m2.	Creatinine	80-90	CD59 molecule (CD59 blood group)	Homo sapiens	116-121
10427952-5	1999	Serum chromogranin A level was positively correlated to serum creatinine and age, but not to tumour stage or grade.	Creatinine	62-72	chromogranin A	Homo sapiens	6-20
10570897-8	1999	The latest serum creatinine and creatinine clearance averages were respectively 66 mumol/l and 105 ml/min/1.73 m2.	Creatinine	32-42	CD59 molecule (CD59 blood group)	Homo sapiens	102-107
10668953-8	1999	Serum creatinine level significantly correlated only with the level of IGF-1 (p=0.02), BMI was significantly correlated with serum endogenous Epo (p<0.01), leptin (p=0.004) and FAI (p<0.005) both in men and women.	Creatinine	6-16	insulin like growth factor 1	Homo sapiens	71-76
9918249-8	1999	vWF:Ag levels were elevated in patients (median 296% vs. controls 109%; p<0.001) and correlated with disease activity, ESR, CRP, ANCA titers, and serum creatinine levels.	Creatinine	155-165	von Willebrand factor	Homo sapiens	0-3
9690223-5	1998	They were analyzed at steady state with a single-pool variable-volume model that determined the creatinine generation rate (GCr) by a methodology that we have previously described.	Creatinine	96-106	nuclear receptor subfamily 3 group C member 1	Homo sapiens	124-127
9884428-6	1999	Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower.	Creatinine	91-101	interleukin 6	Homo sapiens	32-45
9884428-6	1999	Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower.	Creatinine	218-228	interleukin 6	Homo sapiens	32-45
9884428-7	1999	In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy.	Creatinine	70-80	interleukin 6	Homo sapiens	7-20
9884428-7	1999	In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy.	Creatinine	155-165	interleukin 6	Homo sapiens	7-20
9884428-8	1999	Steroid therapy improved 24-hour urinary protein excretion, serum creatinine, and creatinine clearance in the interleukin-6-positive patients, while these parameters worsened without steroid therapy.	Creatinine	82-92	interleukin 6	Homo sapiens	110-123
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Creatinine	155-165	tumor necrosis factor	Homo sapiens	34-43
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Creatinine	155-165	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
9879598-5	1998	Urine collagenase activity was higher in the group of patients than in the control group (8.59 +/- 4.26 pmol AMC/mg creatinine per min-1 vs control 3.84 +/- 2.09 pmol AMC/mg creatinine per min-1 P < 0.02).	Creatinine	116-126	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
9879598-6	1998	Urine excretion of fibronectin (45.60 ng/mg creatinine vs control 10.30 ng/mg creatinine; P < 0.04) and TGF-beta 1 levels in the urine were higher than in controls (283.55 +/- 248.13 pg/ml vs 36.11 +/- 48.01 pg/ml; P < 0.01).	Creatinine	44-54	fibronectin 1	Homo sapiens	19-30
9879598-6	1998	Urine excretion of fibronectin (45.60 ng/mg creatinine vs control 10.30 ng/mg creatinine; P < 0.04) and TGF-beta 1 levels in the urine were higher than in controls (283.55 +/- 248.13 pg/ml vs 36.11 +/- 48.01 pg/ml; P < 0.01).	Creatinine	78-88	fibronectin 1	Homo sapiens	19-30
9822513-9	1998	0-12148, P =.01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P =.005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P =.005).	Creatinine	49-59	interleukin 6	Homo sapiens	17-30
9853701-10	1998	A significant correlation was found between IL-6 values and CRP, ALT, total bilirubin, GGT and creatinine, but not amylase.	Creatinine	95-105	interleukin 6	Homo sapiens	44-48
9702469-4	1998	There was a significant correlation between soluble VCAM-1 and log10 (urinary albumin excretion) in 69 patients with normal serum creatinine levels (r = 0.51, p < 0.0001) and a significant correlation between soluble VCAM-1 and log10 (serum creatinine) in all the patients (r = 0.83, p < 0.0001).	Creatinine	130-140	vascular cell adhesion molecule 1	Homo sapiens	52-58
9745872-4	1998	Elevated urinary microalbumin/creatinine ratios (U Alb/Cr) >20 mg/g Cr are reported in 39%-43% of adults with HbSS, and studies are ongoing in this age group to assess the effect of attenuated proteinuria by ACEI on long-term renal function.	Creatinine	30-40	albumin	Homo sapiens	51-54
10023646-9	1999	Multiple regression analysis identified that black race and weight were positively associated, whereas dialysate/plasma creatinine ratio (D/P(Creat)) and age had a negative effect on serum albumin level.	Creatinine	120-130	albumin	Homo sapiens	189-196
9810145-4	1998	Pretreatment of rats with iNOS inhibitor aminoguanidine, however, suppressed the development of proximal tubule epithelial cell injury and prevented an increase in blood urea nitrogen and serum creatinine as well as resulting in a marked fall in iNOS mRNA and protein in rats with HgCl2-induced ARF.	Creatinine	194-204	nitric oxide synthase 2	Rattus norvegicus	26-30
9830237-9	1998	Plasma endothelin-1 concentration had a negative correlation with creatinine clearance (r = -0.65, p < 0.001), as did atrial natriuretic peptide concentrations (r = -0.44, p = 0.012).	Creatinine	66-76	endothelin 1	Homo sapiens	7-19
9785916-3	1998	Creatinine clearance (mean 56 +/- 7.6 ml/min) showed an inverse correlation with plasma ET-1 levels (p < 0.05) in cirrhotics.	Creatinine	0-10	endothelin 1	Homo sapiens	88-92
9702931-3	1998	In subjects with LVH (SV1 + R(V5, V6) > or = 3.5mV), a stepwise multiple regression analysis revealed that SV1 + R(V5, V6) was associated with plasma renin activity (PRA) in both males and females, and with creatinine concentration (Cr) in males.	Creatinine	210-220	renin	Homo sapiens	153-158
9706420-5	1998	The MMP-3 levels were significantly higher in SLE patients who had a history of the following abnormalities: persistent proteinuria, cellular casts, anti-double stranded DNA antibodies, decreased C3, decreased creatinine clearance (p < 0.001), circulating immune complex (p < 0.01), malar rash, hypoalbuminemia, or decreased C4 (p < 0.05).	Creatinine	210-220	matrix metallopeptidase 3	Homo sapiens	4-9
9661594-6	1998	Serum osteocalcin concentrations were significantly lower, both in patients of group 1 and group 2, compared with healthy subjects (5.1 +/- 0.6 and 4.5 +/- 0.3 vs. 7.9 +/- 0.2 micrograms/L, P < 0.05), whereas urinary cross-linked N-telopeptide of type I collagen concentrations were similar in the three groups of subjects (72.8 +/- 2.2, 71.6 +/- 2.7, and 64.6 +/- 1.7 nmol bone collagen equivalent/mmol creatinine).	Creatinine	407-417	bone gamma-carboxyglutamate protein	Homo sapiens	6-17
9649959-12	1998	A specific renal protective effect of ACE-inhibitors in diabetic nephropathy has been demonstrated in IDDM patients with moderately reduced kidney function (s-creatinine > 133 mumol/l) while the data conflict with NIDDM patients.	Creatinine	159-169	angiotensin I converting enzyme	Homo sapiens	38-41
9621288-3	1998	In a group of animals given the angiotensin-converting enzyme inhibitor enalapril (Enal; 100 mg/L) in their drinking water for 4 wk, beginning 1 wk before BEA injection, creatinine clearance improved significantly (BEA 0.33 versus Enal + BEA 0.52 ml/min per 100 g body wt, P = 0.01) and albumin excretion fell to zero.	Creatinine	170-180	angiotensin I converting enzyme	Rattus norvegicus	32-61
9650466-2	1998	Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr).	Creatinine	75-85	endothelin 1	Homo sapiens	8-12
9650466-5	1998	Plasma ET-1 concentrations were elevated in children with ARF during the period of peak serum creatinine concentration.	Creatinine	94-104	endothelin 1	Homo sapiens	7-11
9650466-6	1998	During the course of ARF, the lowest urinary ET-1/Cr value occurred during the period of peak serum creatinine, whereas the plasma ET-1 concentration declined after the peak.	Creatinine	100-110	endothelin 1	Homo sapiens	45-49
9597940-3	1998	The rapid falls in serum creatinine concentrations and increased creatinine clearances the first weeks after grafting were accompanied by rapidly reversed hypercalcemia and hypermagnesemia, induced hypophosphatemia, maintained parathyroid hormone (PTH) excess and calcitriol deficiency, and decreased alkaline phosphatases.	Creatinine	25-35	parathyroid hormone	Homo sapiens	227-246
9597940-3	1998	The rapid falls in serum creatinine concentrations and increased creatinine clearances the first weeks after grafting were accompanied by rapidly reversed hypercalcemia and hypermagnesemia, induced hypophosphatemia, maintained parathyroid hormone (PTH) excess and calcitriol deficiency, and decreased alkaline phosphatases.	Creatinine	65-75	parathyroid hormone	Homo sapiens	227-246
9690231-7	1998	Serum albumin and prealbumin concentrations both correlated with the serum creatinine concentration (r = 0.378 and r = 0.347, respectively; P"s < 0.001), and were inversely associated with the CRP (r = -0.254 and r = -0.354, respectively; P"s < 0.001).	Creatinine	75-85	albumin	Homo sapiens	0-13
9690231-9	1998	Using multiple regression analysis to further explore these relationships, the serum creatinine concentration was inversely associated with CRP (r = -0.140; P < 0.001).	Creatinine	85-95	C-reactive protein	Homo sapiens	140-143
9690231-10	1998	However, after adjustment for the linkage of the serum creatinine with the serum albumin concentration (r = -0.378; P < 0.001), no relationship with creatinine was observed.	Creatinine	55-65	albumin	Homo sapiens	75-88
9690231-16	1998	A logistic regression analysis performed using the laboratory variables revealed a strong, independent, and inverse relationships between the serum albumin and creatinine concentrations, total lymphocyte count, and the odds risk of death.	Creatinine	160-170	albumin	Homo sapiens	142-155
9678681-8	1998	Blood PSP levels were also elevated in patients who had renal impairment with a decreased creatinine clearance.	Creatinine	90-100	regenerating family member 1 alpha	Homo sapiens	6-9
9705035-8	1998	In the 22 hypertensive patients, TNFalpha levels were negatively correlated with serum creatinine (r=0.60; P < 0.01), and ET-1 levels were positively correlated with UAE (r=0.47, P < 0.05).	Creatinine	87-97	tumor necrosis factor	Homo sapiens	33-41
9579608-7	1998	At 1 month, the patients with suboptimal graft function (n=9) (with creatinine levels above 200 micromol/mL) showed higher number of CD4+ T cells, delayed recovery of CD8+ lymphocytes, and higher percentage of activated lymphocytes from month +3 on than well-functioning kidney recipients.	Creatinine	68-78	CD4 molecule	Homo sapiens	133-136
9551397-12	1998	Tumor necrosis factor-alpha excretion was significantly increased in MGN (41 +/- 8 pg/mg creatinine) compared with the controls (13 +/- 2; P = 0.001), and in particular, it correlated with the interstitial expression of LFA-1 (r = 0.71, P = 0.002).	Creatinine	89-99	tumor necrosis factor	Homo sapiens	0-27
9579608-9	1998	Interestingly, the mean percentage of CD4+CD25+ T cells found 36 and 48 months after Tx were positively correlated with creatinine concentration at these times.	Creatinine	120-130	CD4 molecule	Homo sapiens	38-41
9551410-6	1998	Angiotensin converting enzyme inhibition induced a significant reduction in MABP, albuminuria and kidney function in all three groups (II/ID/DD; P < 0.05): (1) MABP (mean +/- SD) 12 +/- 7/5 +/- 7/8 +/- 9 mm Hg (ANOVA, P = 0.02); (2) albuminuria [mean (95% CI)] 61 (34 to 77)/22 (3 to 37)/31 (13 to 46) %, (ANOVA, P < 0.01); and (3) increasing serum creatinine [mean (95% CI)] 8 (4 to 12)/9 (3 to 16)/8 (0 to 16) % (ANOVA, NS), respectively.	Creatinine	355-365	angiotensin I converting enzyme	Homo sapiens	0-29
9691663-5	1998	RESULTS: 1) Height, body weight, body surface area, GOT, GPT and creatinine were found to significantly differ according to serum PG I level; body surface area, GPT and ALP significantly differed according to serum PG II level.	Creatinine	65-75	biglycan	Homo sapiens	130-134
9525348-7	1998	Serum PTH was inversely correlated with serum 25(OH)D (r = -0.25, r = -034,p < 0.001), and positively correlated with serum creatinine (r = 0.14, r = 0.17,p < 0.01) in men and women.	Creatinine	127-137	parathyroid hormone	Homo sapiens	6-9
9557921-7	1998	In contrast, urinary excretion of vasopressin from angiotensinogen-gene knockout mice (0.7+/-0.1 ng/mg creatinine) was greater than that from control mice (0.3+/-0.1 ng/mg creatinine), and those of adrenaline and of noradrenaline were similar for knockout and control mice.	Creatinine	103-113	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	51-66
9574455-7	1998	Serum TATI increased in patients with renal failure (GFR < 20 mL/min) 12.4 times with respect to subjects with normal renal function (p < 0.001, non-parametric Mann-Whitney test), beta 2M increased 7.6 times (p < 0.001) and creatinine 4.7 times (p < 0.001).	Creatinine	233-243	serine peptidase inhibitor Kazal type 1	Homo sapiens	6-10
9623340-9	1998	Creatinine clearance was in negative correlation with TNF alpha concentrations in urine of our patients with IgAN.	Creatinine	0-10	tumor necrosis factor	Homo sapiens	54-63
9599895-2	1998	Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr).	Creatinine	75-85	endothelin 1	Homo sapiens	8-12
9491949-6	1998	Multivariate analysis suggested no change in the prescribing biases previously observed; ACE inhibitor use was related to lower ejection fraction, lower serum creatinine, documentation of left ventricular systolic function, younger patient age, prescription of any diuretic drug, and nonprescription of alternate vasodilators and calcium blockers.	Creatinine	159-169	angiotensin I converting enzyme	Homo sapiens	89-92
9594044-7	1998	Specificity for cTnT was 96% [78-100] in patients with renal impairment (creatinine > 150 mumol/l), 95% [75-100] in continuous ambulatory peritoneal dialysis patients, but in hemodialysis patients it was 75% [53-92] for short-term hemodialysis (< 1 year) and 46% [24-68] for long-term hemodialysis (> 1 year).	Creatinine	73-83	troponin T2, cardiac type	Homo sapiens	16-20
9588580-7	1998	TNF-alpha correlated closely with TNF soluble receptor II (r = 0.8, p < 0.0001) and modestly with serum creatinine (r = 0.6, p < 0.0001), whereas IL-6 plasma levels were not statistically related to kidney function.	Creatinine	107-117	tumor necrosis factor	Homo sapiens	0-9
9509452-7	1998	RESULTS: The D/P creatinine ratio, daily peritoneal and urine protein losses, and extracellular fluid volume (Vecf% LBM and Vecf% Vtbw) were all significantly greater in patients with serum albumin < 37 g/l as compared to those > or = 37 g/l; P < 0.05.	Creatinine	17-27	albumin	Homo sapiens	190-197
9509459-18	1998	PTH was positively correlated with serum creatinine (r = 0.81, P < 0.001).	Creatinine	41-51	parathyroid hormone	Homo sapiens	0-3
9458826-2	1998	After bilateral renal pedicle occlusion for 60 min, serum creatinine increased, peaking at 72 h, and returned to sham levels after 120 h. ANG II levels in ischemic kidneys were significantly increased 24 h after reperfusion but did not differ from levels in sham kidneys after 120 h. Both renal cortical angiotensinogen mRNA and proximal tubular AT1 receptor mRNA were significantly reduced early after reperfusion, returning to sham levels by 120 and 72 h, respectively.	Creatinine	58-68	angiotensinogen	Rattus norvegicus	138-144
9583095-6	1998	We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance.	Creatinine	77-87	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9462378-8	1998	Increased renin levels were observed in ten of the 43 patients and were associated with impaired creatinine clearance.	Creatinine	97-107	renin	Homo sapiens	10-15
9463746-6	1998	Positive relationships were also observed between CA19-9 and both CEA and creatinine.	Creatinine	74-84	CEA cell adhesion molecule 3	Homo sapiens	66-69
9568830-6	1998	Of the many variables analysed, creatinine (r=0.43; P=0.001) and pre-transplant PTH (r=0.31; P=0.02) significantly correlated with post-transplant PTH.	Creatinine	32-42	parathyroid hormone	Homo sapiens	147-150
9458299-0	1998	Serum erythropoietin and creatinine concentrations as predictive factors for response to recombinant human erythropoietin treatment in anaemic tumour patients on chemotherapy.	Creatinine	25-35	erythropoietin	Homo sapiens	107-121
9458299-10	1998	The rate of the response to rHuEPO is high when the baseline serum EPO level is <75 U/l and the serum creatinine concentration is greater than normal (or the estimated creatinine clearance <60 ml/min).	Creatinine	105-115	erythropoietin	Homo sapiens	31-34
9458299-10	1998	The rate of the response to rHuEPO is high when the baseline serum EPO level is <75 U/l and the serum creatinine concentration is greater than normal (or the estimated creatinine clearance <60 ml/min).	Creatinine	171-181	erythropoietin	Homo sapiens	31-34
10453749-6	1998	Significant differences in the time courses of Ccr and C(PF) due to marked intra-individual fluctuations were found in tubular creatinine secretion.	Creatinine	127-137	nuclear receptor subfamily 5 group A member 2	Homo sapiens	55-60
10453749-9	1998	The large intra-individual fluctuations in tubular creatinine secretion in the kidney graft result in significant differences in the time courses of Ccr and C(PF) and a possibility of erroneous evaluation of graft function if based exclusively on Ccr.	Creatinine	51-61	nuclear receptor subfamily 5 group A member 2	Homo sapiens	157-162
10216370-16	1998	Patients with higher concentrations of serum creatinine during UTI had high urine levels of IL-8.	Creatinine	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9487998-9	1997	In contrast to the presurgical findings, at 8 weeks after hypophysectomy there were significant positive correlations between baseline urinary corticoid/creatinine ratios and basal levels and responses for ACTH, indicating return to normal function of the pituitary-adrenocortical axis.	Creatinine	153-163	proopiomelanocortin	Canis lupus familiaris	206-210
9425858-9	1997	On multivariate logistic regression modeling, the following key clinical variables were positively related to the prescription of ACE inhibitors: low ejection fraction, dyspnea and orthopnea, normal creatinine levels, high diastolic blood pressure, cardiomegaly, and increasing age.	Creatinine	199-209	angiotensin I converting enzyme	Homo sapiens	130-133
9532515-8	1997	The Collaborative Study pilot trial has already shown that the angiotensin II receptor antagonist irbesartan is significantly more effective than the calcium antagonist amlodipine on creatinine clearance in hypertensive NIDDM patients.	Creatinine	183-193	angiotensinogen	Homo sapiens	63-77
9453997-5	1997	Serum TATI increased 12.4 times in patients with renal failure (GFR < 20 ml/min) with respect to subjects with normal renal function (P < 0.001, non-parametric Mann-Whitney test), while beta(2m) increased 7.3 times (P < 0.001) and creatinine 4.7 times (P < 0.001).	Creatinine	240-250	serine peptidase inhibitor Kazal type 1	Homo sapiens	6-10
9430852-5	1997	RESULTS: The median urinary TGF-beta 1 excretion (pg/mg creatinine) was significantly higher (1730; range 60-16,970) in MGN patients than in the healthy controls (300; 30-1330; P < 0.0001).	Creatinine	56-66	transforming growth factor beta 1	Homo sapiens	28-38
9430852-9	1997	Immunosuppressive therapy significantly decreased urinary TGF-beta 1 from 2800 (1610-16,960) to 840 (170-1600) pg/mg creatinine (P = 0.028).	Creatinine	117-127	transforming growth factor beta 1	Homo sapiens	58-68
9430873-7	1997	Thus, urinary IL-6/EGF ratio was markedly increased in the former group (> 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P < 0.0001), and was only slightly increased in the latter group (< 3-fold).	Creatinine	145-155	interleukin 6	Homo sapiens	14-18
9436372-1	1997	To determine whether urinary albumin to creatinine ratio (Albumin index) and urinary N-acetyl-beta-D-glucosaminidase (NAG) to creatinine ratio (NAG index) in random spot urine samples can be sued to predict the early stage of diabetic nephropathy in the elderly non-insulin dependent diabetic patients, we measured these concentrations in 150 non-diabetics, 61 diabetics without retinopathy and 56 diabetics with retinopathy.	Creatinine	40-50	albumin	Homo sapiens	29-36
9425392-11	1997	A linear relationship was found only between the 3-month values of serum osteocalcin and the urine hydroxyproline/creatinine ratio in both pre-menopausal (r = 0.87, P < 0.01) and post-menopausal (r = 0.72, P < 0.05) patients.	Creatinine	114-124	bone gamma-carboxyglutamate protein	Homo sapiens	73-84
9350678-8	1997	Serum creatinine correlated with TNF-alpha soluble receptors but not with the TNF-alpha.	Creatinine	6-16	tumor necrosis factor	Homo sapiens	33-42
9323090-7	1997	Adrenomedullin increased urine sodium (threefold, P<.05), creatinine (P<.05) and cAMP excretion (P<.01), creatinine clearance (P<.05), and renal production of cAMP (P<.05), whereas urine output was maintained during infusion and raised after infusion (P<.05).	Creatinine	61-71	pro-adrenomedullin	Ovis aries	0-14
9323090-7	1997	Adrenomedullin increased urine sodium (threefold, P<.05), creatinine (P<.05) and cAMP excretion (P<.01), creatinine clearance (P<.05), and renal production of cAMP (P<.05), whereas urine output was maintained during infusion and raised after infusion (P<.05).	Creatinine	114-124	pro-adrenomedullin	Ovis aries	0-14
9323090-11	1997	Despite the clear fall in arterial pressure, adrenomedullin increased creatinine clearance and sodium excretion and maintained urine output.	Creatinine	70-80	pro-adrenomedullin	Ovis aries	45-59
9267943-12	1997	Rectal temperature and creatinine concentrations correlated significantly with sTNFR 60, sTNFR 80, sIL-6R, and IL-6 concentrations.	Creatinine	23-33	interleukin 6	Homo sapiens	100-104
9256171-13	1997	IGF-I also ameliorated the nephrotoxicity of cyclosporine, with better values of creatinine and blood urea nitrogen (P<0.05).	Creatinine	81-91	insulin like growth factor 1	Homo sapiens	0-5
11669950-0	1997	H(+)/AuPPh(3)(+) Exchange for the Hydride Complexes CpMoH(CO)(2)(L) (L = PMe(3), PPh(3), CO).	Creatinine	34-41	caveolin 1	Homo sapiens	7-13
9249777-7	1997	Serum albumin was correlated with serum creatinine (r = 0.45, P = 0.01), daily urine protein excretion (r = -0.42, P = 0.02) and uncorrected weekly creatinine clearance (r = -0.39) in females, but not with any index of body composition in either gender.	Creatinine	40-50	albumin	Homo sapiens	0-13
9249777-7	1997	Serum albumin was correlated with serum creatinine (r = 0.45, P = 0.01), daily urine protein excretion (r = -0.42, P = 0.02) and uncorrected weekly creatinine clearance (r = -0.39) in females, but not with any index of body composition in either gender.	Creatinine	148-158	albumin	Homo sapiens	0-13
9203185-2	1997	Urinary TGF-beta, expressed as a ratio to urinary creatinine (ng/mg creatinine), was elevated in patients with IgA nephritis and focal glomerulosclerosis, and was significantly higher than in patients with other types of glomerular diseases and healthy controls.	Creatinine	50-60	transforming growth factor beta 1	Homo sapiens	8-16
9203185-2	1997	Urinary TGF-beta, expressed as a ratio to urinary creatinine (ng/mg creatinine), was elevated in patients with IgA nephritis and focal glomerulosclerosis, and was significantly higher than in patients with other types of glomerular diseases and healthy controls.	Creatinine	68-78	transforming growth factor beta 1	Homo sapiens	8-16
9211022-3	1997	Relatively few patients with left ventricular systolic dysfunction and a serum creatinine > or = 2 mg/dl receive an ACE inhibitor in clinical practice.	Creatinine	79-89	angiotensin I converting enzyme	Homo sapiens	119-122
9133555-7	1997	Urinary levels of bioassayable TGF-beta were also significantly increased in diabetic patients compared with nondiabetic patients (2.435 +/- 0.385 vs. 0.569 +/- 0.190 ng/mg creatinine, respectively; P < 0.001).	Creatinine	173-183	transforming growth factor beta 1	Homo sapiens	31-39
9161853-2	1997	We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women.	Creatinine	12-22	interleukin 6	Homo sapiens	51-55
9161853-2	1997	We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women.	Creatinine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9054845-7	1997	Patients with ischemia had an increase in urine bFGF compared with nonischemic patients (1052 +/- 245 versus -278 +/- 130 pg/g creatinine, P < .0001).	Creatinine	127-137	fibroblast growth factor 2	Homo sapiens	48-52
9179469-8	1997	Patients treated with insulin had greater square root of lipoprotein (a) levels, even after adjusting for serum creatinine and total cholesterol (5.87 +/- 0.35 vs. 4.76 +/- 0.36 (mean +/- S.E.	Creatinine	112-122	insulin	Homo sapiens	22-29
9179469-11	1997	Significant and independent relationships have been found between this variable and serum creatinine, total cholesterol and insulin therapy.	Creatinine	90-100	insulin	Homo sapiens	124-131
9649287-10	1998	Levels of serum soluble interleukin-2 receptor correlated significantly with levels of creatinine (r=0.616, p <0.0001) and beta2-microglobulin (r=0.803, p <0.0001), and levels of urinary alpha1-microglobulin (r=0.753, p <0.0001) and microalbumin (r=0.673, p <0.0001).	Creatinine	87-97	interleukin 2	Homo sapiens	24-37
9481731-7	1998	The mass transfer area coefficient of creatinine, representing effective peritoneal surface area, decreased from 10.7 +/- 1.3 ml/min/1.73 m2 (recumbent) to 9.9 +/- 1.4 (upright; P = 0.08).	Creatinine	38-48	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
9245950-3	1997	RESULTS: An increased urinary excretion of NEP as well as microproteins was found only in subjects excreting more than 5 micrograms Cd/g creatinine.	Creatinine	137-147	membrane metalloendopeptidase	Homo sapiens	43-46
9245950-6	1997	CONCLUSIONS: The data suggest that NEP enzymuria is high even at low exposures to Cd (with a threshold of urinary cadmium excretion (U-Cd) at 5 micrograms/g creatinine), indicating early structural alterations.	Creatinine	157-167	membrane metalloendopeptidase	Homo sapiens	35-38
9201373-4	1997	U-EPX levels were increased in children with asthma compared with controls (median 68.4 vs 35.3 micrograms/mmol creatinine; P < 0.0001).	Creatinine	112-122	eosinophil peroxidase	Homo sapiens	2-5
9201373-5	1997	In addition, U-EPX levels were higher in symptomatic than in asymptomatic patients (median 123.5 vs 48.9 micrograms/mmol creatinine; P < 0.0001) independent of treatment modalities (i.e., inhaled steroids or disodium cromoglycate) or atopy (median 65.1 vs 86.0 micrograms/mmol creatinine).	Creatinine	121-131	eosinophil peroxidase	Homo sapiens	15-18
9205939-6	1997	The effect of atenolol on ANP positively correlated with duration of hypertension (r = 0.74), ECG score for LVH (r = 0.73) and serum creatinine (r = 0.68).	Creatinine	133-143	natriuretic peptide A	Homo sapiens	26-29
9205939-7	1997	Individual changes in ANP by zofenopril negatively correlated with pretreatment ANP (r = -0.69), ECG score for LVH (r = -0.44) and serum creatinine (r = -0.41).	Creatinine	137-147	natriuretic peptide A	Homo sapiens	22-25
21590110-2	1997	The median bFGF value in the patient group was 3.41 ng bFGF/g creatinine (range: 0-153.6), significantly higher than the median levels in the control group (1.39 ng/g creatinine; range: 0-4.5).	Creatinine	62-72	fibroblast growth factor 2	Homo sapiens	11-15
21590110-2	1997	The median bFGF value in the patient group was 3.41 ng bFGF/g creatinine (range: 0-153.6), significantly higher than the median levels in the control group (1.39 ng/g creatinine; range: 0-4.5).	Creatinine	62-72	fibroblast growth factor 2	Homo sapiens	55-59
21590110-2	1997	The median bFGF value in the patient group was 3.41 ng bFGF/g creatinine (range: 0-153.6), significantly higher than the median levels in the control group (1.39 ng/g creatinine; range: 0-4.5).	Creatinine	167-177	fibroblast growth factor 2	Homo sapiens	11-15
21590110-3	1997	On the basis of the optimal cut-off point of 2.64 ng bFGF/g creatinine, the sensitivity of the test for detecting bladder cancer was 61.5% and the specificity 76.9%.	Creatinine	60-70	fibroblast growth factor 2	Homo sapiens	53-57
9100037-3	1997	As creatinine clearance decreased below 80 mL/m, there was a significant decrease in plasma calcitriol and a slow and progressive significant increment in plasma parathyroid hormone (PTH).	Creatinine	3-13	parathyroid hormone	Homo sapiens	162-181
9815721-11	1997	The only significant difference in toxicities occurring through the eighth dose of IL-2 was in the maximum elevation of serum creatinine (mean, 1.7 +/- 0.8 for placebo versus 1.5 +/- 0.6 mg/dl for LSF, P = 0.013).	Creatinine	126-136	interleukin 2	Homo sapiens	83-87
9105763-6	1997	IgAN patients with positive TXS mRNA had significantly reduced GFR with elevated serum creatinine and serum beta 2-microglobulin levels.	Creatinine	87-97	thromboxane A synthase 1	Homo sapiens	28-31
9148377-4	1997	In the recently completed trial of angiotensin converting enzyme (ACE) inhibition in diabetic nephropathy, ACE inhibitors were specifically shown to decrease dramatically the risk of doubling of serum creatinine or reaching a combined outcome of end-stage renal disease or death independent of their effect on systemic blood pressure.	Creatinine	201-211	angiotensin I converting enzyme	Homo sapiens	35-64
9148377-4	1997	In the recently completed trial of angiotensin converting enzyme (ACE) inhibition in diabetic nephropathy, ACE inhibitors were specifically shown to decrease dramatically the risk of doubling of serum creatinine or reaching a combined outcome of end-stage renal disease or death independent of their effect on systemic blood pressure.	Creatinine	201-211	angiotensin I converting enzyme	Homo sapiens	66-69
9148377-4	1997	In the recently completed trial of angiotensin converting enzyme (ACE) inhibition in diabetic nephropathy, ACE inhibitors were specifically shown to decrease dramatically the risk of doubling of serum creatinine or reaching a combined outcome of end-stage renal disease or death independent of their effect on systemic blood pressure.	Creatinine	201-211	angiotensin I converting enzyme	Homo sapiens	107-110
9040425-1	1997	Normalization of blood pressure--and use of an ACE inhibitor or AT1-receptor blocker for patients with abnormal albumin or creatinine levels--can prevent or significantly slow the rate of progression toward end-stage renal disease.	Creatinine	123-133	angiotensin I converting enzyme	Homo sapiens	47-50
9124404-4	1997	IGF-I- and placebo-treated groups were well matched for sex, age, type of surgery, renal ischemic time during surgery (ischemic index), baseline creatinine clearance, and baseline serum creatinine.	Creatinine	145-155	insulin like growth factor 1	Homo sapiens	0-5
9124404-4	1997	IGF-I- and placebo-treated groups were well matched for sex, age, type of surgery, renal ischemic time during surgery (ischemic index), baseline creatinine clearance, and baseline serum creatinine.	Creatinine	186-196	insulin like growth factor 1	Homo sapiens	0-5
9085256-9	1997	The inhibition of renal MIF expression was paralleled by a significant inhibition of glomerular and interstitial macrophage infiltration (p < 0.001 versus saline treated), a significant suppression of renal injury (proteinuria and serum creatinine), and a marked reduction in histologic damage (glomerular hypercellularity, crescent formation, and interstitial fibrosis; all p < 0.01 versus saline treated).	Creatinine	240-250	macrophage migration inhibitory factor	Rattus norvegicus	24-27
9166938-5	1997	Receiver-operating characteristic (ROC) curves were used to determine the optimal cut-off values of TGF-beta1 (50 microg g(-1) creatinine) and AFP (100 ng ml(-1)).	Creatinine	127-137	transforming growth factor beta 1	Homo sapiens	100-109
9453448-6	1997	In contrast, urinary ir-ET-1 excretion was significantly greater in uremic rats and was correlated with the elevation of serum creatinine and proteinuria (r = 0.795, and 0.922, p < 0.01, respectively).	Creatinine	127-137	endothelin 1	Rattus norvegicus	24-28
9195205-5	1997	In short-term samples urinary GH excretion depends on urinary volume and should thus be expressed in nanograms per gram creatinine, whereas 24-hour samples correlate best when urinary GH is expressed as nanograms per period.	Creatinine	120-130	growth hormone 1	Homo sapiens	30-32
9387136-8	1997	Decreased renal formation of cytokines was reflected by a lower urinary excretion ratio of transforming growth factor (TGF)-beta/ creatinine (C: 0.363 +/- 0.183, P: 0.232 +/- 0.085 ng TGF-beta/mg creatinine, p < 0.05).	Creatinine	196-206	transforming growth factor, beta 1	Rattus norvegicus	119-128
8995745-10	1997	Considering the data from control and CHN patients, NEP enzymuria positively correlated with individual creatinine clearance values (r = 0.76; P = 0.0001) and negatively correlated with urinary microproteins levels (r = -0.55; P = 0.00001).	Creatinine	104-114	membrane metalloendopeptidase	Homo sapiens	52-55
8995745-14	1997	A direct correlation between creatinine clearance and NEP excretion was found longitudinally in each case.	Creatinine	29-39	membrane metalloendopeptidase	Homo sapiens	54-57
9381389-3	1997	Mechanisms of nephrotoxic action of RPS involve disturbances of Ca metabolism (hypercalcemia), high concentration of blood endothelin-1 which directly correlated with baseline creatinine in the serum and deterioration of renal function after RPS introduction.	Creatinine	176-186	endothelin 1	Homo sapiens	123-135
8981662-6	1996	The maximum increase of TATI was from a mean basal value of 8.51 +/- 5.58 micrograms l-1 in subjects with normal renal function to 107.27 +/- 63.34 micrograms l-1 in patients with renal failure; beta 2M increased from 1.45 +/- 0.38 to 11.16 +/- 5.73 mg l-1 and creatinine from 1.05 +/- 0.17 to 5.07 +/- 1.93 mg dl-1.	Creatinine	261-271	serine peptidase inhibitor Kazal type 1	Homo sapiens	24-28
9058369-6	1997	Creatinine clearance was also increased with the highest calcitonin concentrations.	Creatinine	0-10	calcitonin related polypeptide alpha	Homo sapiens	57-67
8990356-12	1996	The mean serum creatinine level was 1.2+/-0.8 mg/dl, and the calculated creatinine clearance was 82+/-26 ml/min/1.73 m2.	Creatinine	72-82	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
8957048-12	1996	PTH level correlated with serum creatinine and serum albumin in HD but only with serum creatinine in PD, supporting the inference that patients with high enrollment PTH were better nourished than those with lower PTH.	Creatinine	32-42	parathyroid hormone	Homo sapiens	0-3
8967668-13	1996	In the growth hormone group, significant increases were seen in the following markers of bone turnover: osteocalcin (4.4 +/- 3.6 mg/L to 7.2 +/- 4.6 mg/L) and urinary pyridinoline (39.0 +/- 19.8 nmol/mmol of creatinine to 55.7 +/- 25.5 nmol/mmol of creatinine) and deoxypyridinoline (8.4 +/- 7.1 nmol/mmol of creatinine to 14.9 +/- 9.4 nmol/mmol of creatinine).	Creatinine	208-218	growth hormone 1	Homo sapiens	7-21
8967668-13	1996	In the growth hormone group, significant increases were seen in the following markers of bone turnover: osteocalcin (4.4 +/- 3.6 mg/L to 7.2 +/- 4.6 mg/L) and urinary pyridinoline (39.0 +/- 19.8 nmol/mmol of creatinine to 55.7 +/- 25.5 nmol/mmol of creatinine) and deoxypyridinoline (8.4 +/- 7.1 nmol/mmol of creatinine to 14.9 +/- 9.4 nmol/mmol of creatinine).	Creatinine	249-259	growth hormone 1	Homo sapiens	7-21
8967668-13	1996	In the growth hormone group, significant increases were seen in the following markers of bone turnover: osteocalcin (4.4 +/- 3.6 mg/L to 7.2 +/- 4.6 mg/L) and urinary pyridinoline (39.0 +/- 19.8 nmol/mmol of creatinine to 55.7 +/- 25.5 nmol/mmol of creatinine) and deoxypyridinoline (8.4 +/- 7.1 nmol/mmol of creatinine to 14.9 +/- 9.4 nmol/mmol of creatinine).	Creatinine	249-259	growth hormone 1	Homo sapiens	7-21
8967668-13	1996	In the growth hormone group, significant increases were seen in the following markers of bone turnover: osteocalcin (4.4 +/- 3.6 mg/L to 7.2 +/- 4.6 mg/L) and urinary pyridinoline (39.0 +/- 19.8 nmol/mmol of creatinine to 55.7 +/- 25.5 nmol/mmol of creatinine) and deoxypyridinoline (8.4 +/- 7.1 nmol/mmol of creatinine to 14.9 +/- 9.4 nmol/mmol of creatinine).	Creatinine	249-259	growth hormone 1	Homo sapiens	7-21
9034934-4	1996	In CCl4-treated cirrhotic rats, the osteoid volume decreased while the urinary calcium/creatinine ratio increased.	Creatinine	87-97	C-C motif chemokine ligand 4	Rattus norvegicus	3-7
8943482-9	1996	IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level.	Creatinine	128-138	interleukin 6	Homo sapiens	0-4
8943482-9	1996	IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level.	Creatinine	237-247	interleukin 6	Homo sapiens	0-4
9139274-4	1996	Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine).	Creatinine	127-137	interleukin 6	Homo sapiens	21-25
9139274-4	1996	Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine).	Creatinine	189-199	interleukin 6	Homo sapiens	21-25
9139274-5	1996	Urinary excretion of TGF-beta was also higher (but not significantly in IDDM patients with albuminuria or microalbuminuria (mean = 42.0 +/- 30.0 pg/mg creatinine) than in control group (mean = 27.0 +/- 20.0 pg/mg creatinine).	Creatinine	151-161	transforming growth factor beta 1	Homo sapiens	21-29
9139274-5	1996	Urinary excretion of TGF-beta was also higher (but not significantly in IDDM patients with albuminuria or microalbuminuria (mean = 42.0 +/- 30.0 pg/mg creatinine) than in control group (mean = 27.0 +/- 20.0 pg/mg creatinine).	Creatinine	213-223	transforming growth factor beta 1	Homo sapiens	21-29
8900380-5	1996	The fractional excretion of AVP, plasma atrial natriuretic peptide (ANP) and endothelin-1 (ET-1), urinary ET-1, and FE(ET-1) correlated with the decrease of creatinine clearance (Ccr).	Creatinine	157-167	arginine vasopressin	Homo sapiens	28-31
8900380-5	1996	The fractional excretion of AVP, plasma atrial natriuretic peptide (ANP) and endothelin-1 (ET-1), urinary ET-1, and FE(ET-1) correlated with the decrease of creatinine clearance (Ccr).	Creatinine	157-167	endothelin 1	Homo sapiens	77-89
8914485-7	1996	The reagentless planar sensors for creatinine and creatine have fast response time (t95 = 1 min), linear response up to 1.2 mM in batch-type and 2.0 mM in flow injection analysis and a detection limit of 10-20 muM.	Creatinine	35-45	latexin	Homo sapiens	210-213
8933637-11	1996	In male and female mice of the 20% erythritol group, the creatinine-normalized urinary excretion of protein, K-glutamyltransferase (GGT), and electrolytes (Na+, K+, Ca2+, Pi, citrate) was significantly increased while urinary N-acetylglucosaminidase (NAG) remained unchanged.	Creatinine	57-67	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	226-249
8933637-11	1996	In male and female mice of the 20% erythritol group, the creatinine-normalized urinary excretion of protein, K-glutamyltransferase (GGT), and electrolytes (Na+, K+, Ca2+, Pi, citrate) was significantly increased while urinary N-acetylglucosaminidase (NAG) remained unchanged.	Creatinine	57-67	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	251-254
8933637-13	1996	In rats, the creatinine-normalized urinary excretion of GGT, NAG, and some electrolytes (Na+, K+, and Ca2+) was increased in some erythritol groups but a clear dose-response relationship was evident only for calcium.	Creatinine	13-23	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	61-64
8968688-4	1996	Multiple logistic regression analyses showed that duration of diabetes, glycosylated haemoglobin, type of treatment (insulin treatment versus non-insulin treatment), systolic and diastolic blood pressures and serum creatinine, showed a positive association with retinopathy while body mass index (BMI) showed an inverse association.	Creatinine	215-225	insulin	Homo sapiens	146-153
8872976-9	1996	A significant correlation between creatinine and LVM indexed for height was found in the CRF group.	Creatinine	34-44	modulator of VRAC current 1	Homo sapiens	49-52
9122011-2	1996	The aim of this study was to analyse the relationship between glucose, insulin and changes of creatinine clearance and proteinuria in patients with primary glomerulonephritis and normal renal function.	Creatinine	94-104	insulin	Homo sapiens	71-78
8694207-4	1996	The overall mean (SD) urea clearance was 26.6 (6.0) ml.min-1 and the overall creatinine clearance was 30.1 (6.3) ml.min-1.	Creatinine	77-87	CD59 molecule (CD59 blood group)	Homo sapiens	116-121
8642619-9	1996	Catalase and Cu2+/Zn2+ SOD activities were increased in the groups of workers with higher creatinine-corrected urinary Hg concentrations when compared with the group of lower creatinine-corrected urinary Hg concentrations.	Creatinine	90-100	catalase	Homo sapiens	0-8
8642619-9	1996	Catalase and Cu2+/Zn2+ SOD activities were increased in the groups of workers with higher creatinine-corrected urinary Hg concentrations when compared with the group of lower creatinine-corrected urinary Hg concentrations.	Creatinine	90-100	superoxide dismutase 1	Homo sapiens	13-26
8642619-9	1996	Catalase and Cu2+/Zn2+ SOD activities were increased in the groups of workers with higher creatinine-corrected urinary Hg concentrations when compared with the group of lower creatinine-corrected urinary Hg concentrations.	Creatinine	175-185	catalase	Homo sapiens	0-8
8642619-9	1996	Catalase and Cu2+/Zn2+ SOD activities were increased in the groups of workers with higher creatinine-corrected urinary Hg concentrations when compared with the group of lower creatinine-corrected urinary Hg concentrations.	Creatinine	175-185	superoxide dismutase 1	Homo sapiens	13-26
8642619-10	1996	Catalase activity was positively correlated with the creatinine-corrected concentration of Hg in urine, and Cu2+/Zn2+ SOD activity was slightly correlated with the creatinine-corrected concentration of Hg in urine.	Creatinine	53-63	catalase	Homo sapiens	0-8
8642619-10	1996	Catalase activity was positively correlated with the creatinine-corrected concentration of Hg in urine, and Cu2+/Zn2+ SOD activity was slightly correlated with the creatinine-corrected concentration of Hg in urine.	Creatinine	164-174	superoxide dismutase 1	Homo sapiens	108-121
8651241-5	1996	NO2-/NO3- urinary excretion (0.45 +/- 0.14 v 0.25 +/- 0.04 micromol/micromol urinary creatinine [controls], P < 0.005, v 0.28 +/- 0.05 [pseudo-Bartters], P < 0.01) and cyclic GMP urinary excretion (0.057 +/- 0.028 v 0.022 +/- 0.01 micromol/micromol of urinary creatinine [controls], P < 0.009, v 0.024 +/- 0.004 [pseudo-Bartters], P < 0.02) were increased in patients with Bartter"s syndrome in comparison with controls and pseudo-Bartters, and a linear correlation between these two parameters was also present (P < 0.001).	Creatinine	85-95	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
8651241-5	1996	NO2-/NO3- urinary excretion (0.45 +/- 0.14 v 0.25 +/- 0.04 micromol/micromol urinary creatinine [controls], P < 0.005, v 0.28 +/- 0.05 [pseudo-Bartters], P < 0.01) and cyclic GMP urinary excretion (0.057 +/- 0.028 v 0.022 +/- 0.01 micromol/micromol of urinary creatinine [controls], P < 0.009, v 0.024 +/- 0.004 [pseudo-Bartters], P < 0.02) were increased in patients with Bartter"s syndrome in comparison with controls and pseudo-Bartters, and a linear correlation between these two parameters was also present (P < 0.001).	Creatinine	266-276	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
8793228-5	1996	Urinary IGF-I level was significantly increased in CRF (4.0 +/- 0.5 ng/mg creatinine) compared with CRD (2.8 +/- 0.6 ng/mg creatinine) and C (1.8 +/- 1.0 ng/mg) creatinine).	Creatinine	74-84	insulin like growth factor 1	Homo sapiens	8-13
8793228-5	1996	Urinary IGF-I level was significantly increased in CRF (4.0 +/- 0.5 ng/mg creatinine) compared with CRD (2.8 +/- 0.6 ng/mg creatinine) and C (1.8 +/- 1.0 ng/mg) creatinine).	Creatinine	123-133	insulin like growth factor 1	Homo sapiens	8-13
8793228-5	1996	Urinary IGF-I level was significantly increased in CRF (4.0 +/- 0.5 ng/mg creatinine) compared with CRD (2.8 +/- 0.6 ng/mg creatinine) and C (1.8 +/- 1.0 ng/mg) creatinine).	Creatinine	123-133	insulin like growth factor 1	Homo sapiens	8-13
8793228-7	1996	Urinary IGF-I, but not serum IGF-I, demonstrated a significant negative correlation with creatinine clearance.	Creatinine	89-99	insulin like growth factor 1	Homo sapiens	8-13
8793228-10	1996	In contrast, urinary IGF-I level in NIDDM (1.93 +/- 0.31 ng/mg creatinine) did not differ from that in controls (2.00 +/- 0.31 ng/mg creatinine).	Creatinine	63-73	insulin like growth factor 1	Homo sapiens	21-26
8927462-9	1996	When the urine GH was expressed as ng GH/mmol creatinine, the coefficient of variation ranged between 12 and 92% (median, 35%), accounting for approximately 60% of the inter-individual coefficient of variation (mean CV, 56%) and 47% when the urine GH is expressed as ng GH/mmol creatinine.	Creatinine	46-56	growth hormone 1	Homo sapiens	15-17
8927462-9	1996	When the urine GH was expressed as ng GH/mmol creatinine, the coefficient of variation ranged between 12 and 92% (median, 35%), accounting for approximately 60% of the inter-individual coefficient of variation (mean CV, 56%) and 47% when the urine GH is expressed as ng GH/mmol creatinine.	Creatinine	278-288	growth hormone 1	Homo sapiens	15-17
8735680-18	1996	Patients with less than 30 ml min-1 creatinine clearance may require less frequent administration of transnasal butorphanol as compared with subjects with normal or moderately impaired renal function.	Creatinine	36-46	CD59 molecule (CD59 blood group)	Homo sapiens	30-35
8800625-8	1996	The available results from large-scale studies suggest that abnormalities in kidney function (namely an increase in serum creatinine) are observed in 0.9 to 2.4% of patients with MI who, nevertheless, experience some benefit from treatment with ACE inhibitors.	Creatinine	122-132	angiotensin I converting enzyme	Homo sapiens	245-248
8770173-6	1996	Control and L-selectin groups had similar elevations of serum creatinine (1.8 +/- 0.3 vs. 1.7 +/- 0.2 mg/dl) and blood urea nitrogen (111 +/- 17 vs. 128 +/- 12 mg/dl) 24 h postischemia.	Creatinine	62-72	selectin, lymphocyte	Mus musculus	12-22
8707068-5	1996	For hypertension control and renal protection, start ACE inhibitors when serum creatinine is less than 2 mg/dl.	Creatinine	79-89	angiotensin I converting enzyme	Homo sapiens	53-56
8831085-1	1996	UNLABELLED: Raised urinary levels of albumin and N-acetyl-beta-D-glucosaminidase (NAG) are predictive of abnormal renal function and excretion of these substances is often expressed as a creatinine ratio.	Creatinine	187-197	albumin	Homo sapiens	37-44
8694207-6	1996	Creatinine clearance was significantly lower in filters that failed within 24 h (filters < 24 h 27.5 (6.3) ml.min-1; filters > 24 h 32.2 (5.5) ml.min-1).	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
8694207-6	1996	Creatinine clearance was significantly lower in filters that failed within 24 h (filters < 24 h 27.5 (6.3) ml.min-1; filters > 24 h 32.2 (5.5) ml.min-1).	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	152-157
8644056-4	1996	ACEI, however, may not completely inhibit the production of angiotensin II and its effects, and adverse effects like cough and rise in creatinine have been associated with ACEI and reduced degradation of bradykinin.	Creatinine	135-145	kininogen 1	Homo sapiens	204-214
8659493-3	1996	We observed three patients with hereditary glomerulonephritis with plasma creatinine concentrations ranging from 1.7 to 2.0 mg/dL who were treated with angiotensin-converting enzyme inhibitors (ACEIs) for 3.5 to 6 years.	Creatinine	74-84	angiotensin I converting enzyme	Homo sapiens	152-181
8703817-2	1996	Calmodulin excretion was significantly elevated in IMF (0.29 +/- 0.04 microgram/mmol creatinine) (P < 0.001), when compared to polycythaemia vera (PV) (0.14 +/- 0.02), essential thrombocythaemia (ET) (0.13 +/- 0.04), chronic myeloid leukaemia (CML) (0.16 +/- 0.02), unclassified myeloproliferative disorders (UMPD) (0.11 +/- 0.02) and age-matched controls (0.1 +/- 0.02) (P < 0.001).	Creatinine	85-95	calmodulin 1	Homo sapiens	0-10
8659493-4	1996	Angiotensin-converting enzyme inhibitor therapy was accompanied by a decrease in the mean arterial pressure (MAP) from 115 +/- 10 mm Hg to 93 +/- 2 mm Hg (+/- SD), a decrease in the mean urinary protein/creatinine ratio from 2,910 +/- 1,720 mg/g to 391 +/- 355 mg/g, and stabilization of the decline of creatinine clearance with time in two of the three patients.	Creatinine	203-213	angiotensin I converting enzyme	Homo sapiens	0-29
8659493-4	1996	Angiotensin-converting enzyme inhibitor therapy was accompanied by a decrease in the mean arterial pressure (MAP) from 115 +/- 10 mm Hg to 93 +/- 2 mm Hg (+/- SD), a decrease in the mean urinary protein/creatinine ratio from 2,910 +/- 1,720 mg/g to 391 +/- 355 mg/g, and stabilization of the decline of creatinine clearance with time in two of the three patients.	Creatinine	303-313	angiotensin I converting enzyme	Homo sapiens	0-29
8558640-5	1996	Baseline pre-therapy cytokine levels were 3.9 +/- 4.7 pg./mumol creatinine for interleukin-6 and 0.1 +/- 0.2 pg./mumol creatinine for tumor necrosis factor-alpha (all measured by enzyme-linked immunosorbent assay).	Creatinine	119-129	tumor necrosis factor	Homo sapiens	134-161
8821818-10	1996	Both the inhibitors of cytochrome P-450 provided functional (as measured by BUN and creatinine) and histological protection against glycerol-induced acute renal failure.	Creatinine	84-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	23-39
8761013-7	1996	In addition, multiple regression analysis with a forward elimination procedure showed that only the ACE genotype was associated with RI of arcuate arteries (R2 = 0.24, p < 0.01) among the parameters of sex, age, IDDM duration, body mass index, HbA1c, plasma glucose levels, serum levels of total cholesterol and creatinine, urinary albumin excretion index, mean blood pressure and ACE genotype.	Creatinine	315-325	angiotensin I converting enzyme	Homo sapiens	100-103
8804001-1	1996	Hyperkalaemia as well as increased predialysis values for creatinine and phosphate have been reported in many clinical recombinant human erythropoietin (rHu-EPO) trials in haemodialysis patients.	Creatinine	58-68	erythropoietin	Homo sapiens	137-151
8773334-0	1996	Serum albumin for estimating creatinine clearance in the elderly with muscle atrophy.	Creatinine	29-39	albumin	Homo sapiens	0-13
8773334-1	1996	The present study was conducted to develop a special formula to predict creatinine clearance (CCr, ml/min) in the elderly with chronic muscle atrophy using serum albumin (Alb, g/dl).	Creatinine	72-82	albumin	Homo sapiens	162-169
8773334-1	1996	The present study was conducted to develop a special formula to predict creatinine clearance (CCr, ml/min) in the elderly with chronic muscle atrophy using serum albumin (Alb, g/dl).	Creatinine	72-82	albumin	Homo sapiens	171-174
8856262-4	1996	Treatment with vasopressin V1 antagonist significantly reduced the rate of increase in the levels of triglyceride, systolic blood pressure, serum creatinine and BUN, and prevented a significant deterioration in creatinine clearance.	Creatinine	146-156	arginine vasopressin	Rattus norvegicus	15-26
8856262-4	1996	Treatment with vasopressin V1 antagonist significantly reduced the rate of increase in the levels of triglyceride, systolic blood pressure, serum creatinine and BUN, and prevented a significant deterioration in creatinine clearance.	Creatinine	211-221	arginine vasopressin	Rattus norvegicus	15-26
8685020-15	1996	This increased is due to either an increase value of plasmatic creatinine that is present in normal situations or in physiopathologic role played by the ET1 in course of acute renal failure after asphyxia.	Creatinine	63-73	endothelin 1	Homo sapiens	153-156
8766781-5	1996	The suspension of the treatment by erythropoietin permitted the restoration of the creatinine values to levels similar to the ones pointed out before the treatment and a reduction of the blood pressure values.	Creatinine	83-93	erythropoietin	Homo sapiens	35-49
9102924-10	1996	Correlation between TNF alpha level and proteinuria degree and creatinine clearance rate has revealed (statistically) significant relationship (p < 0.05).	Creatinine	63-73	tumor necrosis factor	Homo sapiens	20-29
8525532-6	1995	However, the presence of the C3F allele predicted an increased risk of graft dysfunction (defined as serum creatinine > 150 mumol/L): 61/105 versus 36/78, with a relative risk of 1.4 (P < 0.05).	Creatinine	107-117	lysophosphatidylcholine acyltransferase 3	Homo sapiens	29-32
7503062-4	1995	The mean current creatinine clearance was 88.5 +/- 21.2 mL/min/1.73 m2, which is 92.9% of that in healthy age- and sex-matched controls with two kidneys.	Creatinine	17-27	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
8789184-11	1995	Low serum albumin was also independent of haemoglobin and creatinine: F = 19.52 (P < 0.001), but Hb was not significantly different after adjustment for Alb and creatinine.	Creatinine	58-68	albumin	Homo sapiens	10-17
8749676-6	1995	In the recently completed trial of ACE inhibition in diabetic nephropathy, ACE inhibitors were specifically shown to decrease dramatically the risk of doubling of serum creatinine or reaching a combined outcome of end-stage renal disease or death.	Creatinine	169-179	angiotensin I converting enzyme	Homo sapiens	35-38
8749676-6	1995	In the recently completed trial of ACE inhibition in diabetic nephropathy, ACE inhibitors were specifically shown to decrease dramatically the risk of doubling of serum creatinine or reaching a combined outcome of end-stage renal disease or death.	Creatinine	169-179	angiotensin I converting enzyme	Homo sapiens	75-78
8750167-8	1995	On the other hand, modest negative correlations were found between endothelin-1 and creatinine clearance or effective renal plasma flow.	Creatinine	84-94	endothelin 1	Homo sapiens	67-79
8808225-13	1995	The overestimation of GFR by creatinine (Clc-Cli) decreased during DI-1 from 1.35 +/- 1.69 ml/min to 0.26 +/- 0.60 (P < 0.05) and during DI-2 from 1.01 +/- 1.33 ml/min to 0.10 +/- 0.67 (P < 0.01).	Creatinine	29-39	arginine vasopressin receptor 2	Homo sapiens	67-71
8748403-4	1995	The change in urinary albumin:creatinine and transferrin:creatinine ratios between allocation and 6 months of treatment did not correlate significantly with the lithium dosing schedule (multiple linear regression), but did correlate with total lithium carbonate dose.	Creatinine	57-67	transferrin	Homo sapiens	45-56
7485127-8	1995	Urea and creatinine levels were higher in patients with RLS (P = 0.04 and P = 0.08, respectively); otherwise, no other metabolic or demographic variable was associated with specific sleep disorders or disturbance.	Creatinine	9-19	RLS1	Homo sapiens	56-59
8564794-2	1995	Using an immunoradiometric assay to measure intact PTH levels, we found elevations in intact PTH levels as creatinine clearance approaches 60 ml/minute (serum creatinine near 1.8) and a significant inverse relationship between indices of renal function and intact PTH levels (r = -0.60, P < 0.001 for intact PTH and creatinine clearance.)	Creatinine	107-117	parathyroid hormone	Homo sapiens	51-54
8564794-2	1995	Using an immunoradiometric assay to measure intact PTH levels, we found elevations in intact PTH levels as creatinine clearance approaches 60 ml/minute (serum creatinine near 1.8) and a significant inverse relationship between indices of renal function and intact PTH levels (r = -0.60, P < 0.001 for intact PTH and creatinine clearance.)	Creatinine	107-117	parathyroid hormone	Homo sapiens	93-96
8564794-2	1995	Using an immunoradiometric assay to measure intact PTH levels, we found elevations in intact PTH levels as creatinine clearance approaches 60 ml/minute (serum creatinine near 1.8) and a significant inverse relationship between indices of renal function and intact PTH levels (r = -0.60, P < 0.001 for intact PTH and creatinine clearance.)	Creatinine	107-117	parathyroid hormone	Homo sapiens	93-96
8564794-2	1995	Using an immunoradiometric assay to measure intact PTH levels, we found elevations in intact PTH levels as creatinine clearance approaches 60 ml/minute (serum creatinine near 1.8) and a significant inverse relationship between indices of renal function and intact PTH levels (r = -0.60, P < 0.001 for intact PTH and creatinine clearance.)	Creatinine	107-117	parathyroid hormone	Homo sapiens	93-96
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Creatinine	261-271	tumor necrosis factor	Rattus norvegicus	48-75
8634677-3	1995	Urinary TGF beta activity (reported in relation to urine creatinine concentration, Ucr, mean +/- SD) was higher in patients with focal glomerular sclerosis (mean = 17.32 +/- 15.75/10 micrograms Ucr) and patients with membranous glomerulonephritis (mean = 17.78 +/- 11.53/10 micrograms Ucr) than in normal individuals (mean = 0.8 +/- 0.44/10 micrograms Ucr).	Creatinine	57-67	transforming growth factor beta 1	Homo sapiens	8-16
8634677-4	1995	We also observed that TGF beta activity in urine from patients with focal glomerular sclerosis correlated with their plasma creatinine levels (r = 0.85), suggesting that TGF beta activity may be correlated with other indices of disease progression.	Creatinine	124-134	transforming growth factor beta 1	Homo sapiens	22-30
8634677-4	1995	We also observed that TGF beta activity in urine from patients with focal glomerular sclerosis correlated with their plasma creatinine levels (r = 0.85), suggesting that TGF beta activity may be correlated with other indices of disease progression.	Creatinine	124-134	transforming growth factor beta 1	Homo sapiens	170-178
7551838-5	1995	RESULTS: Median urinary bFGF was higher in patients with active bladder cancer than in those with a clear cystoscopy (5.20 and 2.13 ng/g creatinine, respectively; P < 0.005).	Creatinine	137-147	fibroblast growth factor 2	Homo sapiens	24-28
8770627-10	1995	A significant positive correlation was found between osteocalcin and the hydroxyproline/creatinine ratio in premenopausal and postmenopausal patients, but not in controls.	Creatinine	88-98	bone gamma-carboxyglutamate protein	Homo sapiens	53-64
7551838-6	1995	Median urinary bFGF was also elevated in patients about to undergo TURP (4.52 ng/g creatinine).	Creatinine	83-93	fibroblast growth factor 2	Homo sapiens	15-19
7748016-11	1995	A significant relation was noted between urinary albumin to creatinine ratio and CRP, and the duration of disease.	Creatinine	60-70	C-reactive protein	Homo sapiens	81-84
8530694-6	1995	VEGF:creatinine ratios in early morning urine samples were used to monitor daily urinary VEGF concentrations based on its high correlation (r = 0.77, P < 0.001) with VEGF concentrations in 24 h urine collections.	Creatinine	5-15	vascular endothelial growth factor A	Homo sapiens	89-93
8530694-6	1995	VEGF:creatinine ratios in early morning urine samples were used to monitor daily urinary VEGF concentrations based on its high correlation (r = 0.77, P < 0.001) with VEGF concentrations in 24 h urine collections.	Creatinine	5-15	vascular endothelial growth factor A	Homo sapiens	89-93
8530694-10	1995	A significant increase (P < 0.005, n = 25) was observed in VEGF:creatinine ratios following human chorionic gonadotrophin (HCG) administration.	Creatinine	67-77	vascular endothelial growth factor A	Homo sapiens	62-66
7652762-6	1995	Systolic right ventricular pressure was moderately raised (36 to 48 mmHg) in 5 children; mean creatinine clearance was 99 ml/min/1.73 m2.	Creatinine	94-104	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
7652762-14	1995	Mean creatinine clearance is 101 ml/min/1.73 m2.	Creatinine	5-15	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
7586587-7	1995	In renovascular hypertension chromogranin A correlated positively with serum creatinine; chromogranin A was strongly elevated especially in chronic renal failure.	Creatinine	77-87	chromogranin A	Homo sapiens	29-43
7611253-3	1995	The serum creatinine concentration after 1 year of treatment with erythropoietin was 3.7 mg/dL, which was unchanged from the baseline value of 3.5 mg/dL.	Creatinine	10-20	erythropoietin	Homo sapiens	66-80
7537863-9	1995	In the six other normal subjects, an infusion of desmopressin (1-desamino-8-D-arginine vasopressin) increased the urinary excretion of aquaporin-2 from 0.8 +/- 0.3 to 11.2 +/- 1.6 pmol per milligram of creatinine (P < 0.001).	Creatinine	202-212	arginine vasopressin	Homo sapiens	87-98
7771489-7	1995	The urinary ET-1 excretion correlated directly with creatinine clearance and inversely with tubulointerstitial damage.	Creatinine	52-62	endothelin 1	Rattus norvegicus	12-16
7666599-5	1995	The amount of U-FN, assessed as microgram/g creatinine/24 h, was significantly greater in the patients as a group (348.1 +/- 48.3), than in the controls (108.6 +/- 22.7, p < 0.01).	Creatinine	44-54	fibronectin 1	Homo sapiens	14-18
7666599-8	1995	A highly significant negative correlation existed between endogenous creatinine clearance values and the amounts of U-FN in the patients (r = -0.642, p < 0.01), while there was no such relationship in the controls (r = 0.167, p = NS).	Creatinine	69-79	fibronectin 1	Homo sapiens	116-120
7669872-1	1995	Plasma glucose, glycated hemoglobin lc (HbAlc), urinary albumin excretion rate (AER) and urinary N-acetyl-glucosaminidase (NAG): creatinine ratio were studied in 100 normotensive diabetic patients with no evidence of overt renal disease and in 45 controls, to find out whether the glycaemic control and incipient nephropathy may influence the urinary excretion of NAG.	Creatinine	129-139	N-acetyl-alpha-glucosaminidase	Homo sapiens	123-126
7669872-6	1995	Multiple regression analysis was performed in the whole of diabetics and significant association were identified between urinary NAG excretion and plasma glucose, AER and plasma creatinine (p < 0.0005, r = 0.42).	Creatinine	178-188	N-acetyl-alpha-glucosaminidase	Homo sapiens	129-132
7669872-7	1995	The diabetics with plasma glucose lower to 140 mg/dl had more important correlation NAG: creatinine ratio-AER (p < 0.0001, r = 0.70).	Creatinine	89-99	N-acetyl-alpha-glucosaminidase	Homo sapiens	84-87
8530694-11	1995	VEGF:creatinine ratios correlated poorly (r < 0.34) with plasma oestradiol, follicle number and size.	Creatinine	5-15	vascular endothelial growth factor A	Homo sapiens	0-4
8585420-8	1995	Serum SHBG, an inverse measure of estrogen activity, was positively related to osteocalcin levels (p = 0.004) and the urinary hydroxyproline/creatinine ratio (p = 0.002) and negatively related to the BMD of the trochanter (left trochanter p = 0.02) and the distal radius (p = 0.001).	Creatinine	141-151	sex hormone binding globulin	Homo sapiens	6-10
7544219-6	1995	urinary nitrogen:creatinine ratio was significantly reduced in patients who received IGF-I compared with those given placebo (275.0(17.1) compared with 386.3(23.6), P < 0.01).	Creatinine	17-27	insulin like growth factor 1	Homo sapiens	85-90
7544219-7	1995	The mean urinary 3-methylhistidine:creatinine ratio and nitrogen balance were lower in the IGF-I group, but not significantly so.	Creatinine	35-45	insulin like growth factor 1	Homo sapiens	91-96
7752579-9	1995	At the end of the experiment, elevated plasma renin activity and pCO2, significantly decreased creatinine clearance, blood pH, pO2, base excess, HCO3-, oxygen saturation (P < 0.01), a distinct glomerular proteinuria, and a final anuria were observated.	Creatinine	95-105	PCO2	Sus scrofa	65-69
7479241-6	1995	Only in PHP patients a significant negative correlation was found preoperatively between plasma EPO level and Hct value or creatinine clearance respectively.	Creatinine	123-133	erythropoietin	Homo sapiens	96-99
7736672-2	1995	In this prospective study, we have evaluated the accuracy of the urinary protein/creatinine ratio (UP/UCreat), determined in morning urine specimens, in assessing 24-hour proteinuria (P24).	Creatinine	81-91	transmembrane p24 trafficking protein 2	Homo sapiens	184-187
7752504-6	1995	There was a weak correlation between the urinary level of FN and serum creatinine level and a weak inverse correlation between the urinary level of FN and creatinine clearance.	Creatinine	71-81	fibronectin 1	Homo sapiens	58-60
7752504-6	1995	There was a weak correlation between the urinary level of FN and serum creatinine level and a weak inverse correlation between the urinary level of FN and creatinine clearance.	Creatinine	155-165	fibronectin 1	Homo sapiens	148-150
7732485-5	1995	Serum MMP-3 significantly correlated with serum BUN or serum creatinine levels in SLE patients but not in RA patients.	Creatinine	61-71	matrix metallopeptidase 3	Homo sapiens	6-11
21559679-6	1994	Soluble Ecad urinary level per urinary creatinine level was found to be significantly elevated in 53% of patients suffering from various types of cancers including lung, liver, stomach, colon and rectal cancers, as compared with those in the age-matched healthy subjects.	Creatinine	39-49	cadherin 1	Homo sapiens	8-12
7607760-7	1995	Creatinine generation rate, Gcr, was calculated as the sum of urinary creatinine excretion rate, creatinine accumulation rate within body fluids and extra-renal creatinine excretion rate.	Creatinine	0-10	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-31
7607760-7	1995	Creatinine generation rate, Gcr, was calculated as the sum of urinary creatinine excretion rate, creatinine accumulation rate within body fluids and extra-renal creatinine excretion rate.	Creatinine	70-80	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-31
7607760-7	1995	Creatinine generation rate, Gcr, was calculated as the sum of urinary creatinine excretion rate, creatinine accumulation rate within body fluids and extra-renal creatinine excretion rate.	Creatinine	97-107	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-31
7607760-7	1995	Creatinine generation rate, Gcr, was calculated as the sum of urinary creatinine excretion rate, creatinine accumulation rate within body fluids and extra-renal creatinine excretion rate.	Creatinine	97-107	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-31
8731961-2	1995	It was found that (1) the mean BMC was obviously lower in patients with CRF than that in the normal controls; (2) PTH and CT obviously rose in patients with CRF; (3) the decrease of BMC was strongly correlated with that of creatinine clearance (Ccr).	Creatinine	223-233	calcitonin related polypeptide alpha	Homo sapiens	122-124
8695968-8	1995	Bone GLA protein (BGP) was significantly higher in the KS group (12.7 +/- 4.8 vs 8.9 +/- 5.2 ng/ml; p < 0.02), while serum calcium, serum phosphate, calciotrophic hormones and the fasting urinary hydroxyproline/creatinine ratio (OHP/Creat) were similar in the two groups.	Creatinine	214-224	bone gamma-carboxyglutamate protein	Homo sapiens	0-16
7989949-4	1994	Creatinine values (mean pretherapy, 1.2 mg/dL) increased during therapy and peaked (mean, 2.7 mg/dL) approximately 1 day after discontinuation of the second cycle of IL-2.	Creatinine	0-10	interleukin 2	Homo sapiens	166-170
8534715-1	1995	The association between the use of erythropoietin and urea or creatinine clearance was studied in two populations on continuous peritoneal dialysis (CPD) residing either at an altitude of 1600 m (n = 194) or at sea level (n = 108).	Creatinine	62-72	erythropoietin	Homo sapiens	35-49
8534715-7	1995	Whether inadequate total urea or creatinine clearance is also associated with more frequent erythropoietin use requires further study.	Creatinine	33-43	erythropoietin	Homo sapiens	92-106
7987859-8	1994	Hypercalcemic subjects with increased IL-6 had higher urinary Ca/creatinine levels than patients with normal IL-6 levels (P < 0.005) but this was not the case in normocalcemic subjects.	Creatinine	65-75	interleukin 6	Homo sapiens	38-42
7851030-2	1994	Plasma endothelin-1 (ET-1) was extremely high in all patients on admission (12.1 +/- 1.0 pg/ml, normal 1.5 +/- 0.5 pg/ml), and changed in parallel with the serum creatinine level.	Creatinine	162-172	endothelin 1	Homo sapiens	7-19
7851030-2	1994	Plasma endothelin-1 (ET-1) was extremely high in all patients on admission (12.1 +/- 1.0 pg/ml, normal 1.5 +/- 0.5 pg/ml), and changed in parallel with the serum creatinine level.	Creatinine	162-172	endothelin 1	Homo sapiens	21-25
7807770-10	1994	A significant positive liner correlation was noted between plasma ET-1 and serum creatinine during the first week following living transplantation.	Creatinine	81-91	endothelin 1	Homo sapiens	66-70
7695067-7	1994	A higher urinary cotinine/creatinine ratio was associated with higher total IgE level.	Creatinine	26-36	immunoglobulin heavy constant epsilon	Homo sapiens	76-79
7858333-4	1994	The following results were obtained: 1) GSHPx-P activity was significantly decreased in renal impairment patients; 2) GSHPx-P activity negatively correlated with serum creatinine values in renal impairment patients (r = -0.55; p < 0.001); and 3) the enzyme activity slightly increased after the session in hemodialysis patients.	Creatinine	168-178	glutathione peroxidase 3	Homo sapiens	118-125
7918315-6	1994	Fasting insulin concentration was significantly associated with levels of glucose, triglycerides, uric acid, serum albumin, creatinine, and fibrinogen as well as resting heart rate.	Creatinine	124-134	insulin	Homo sapiens	8-15
7527629-5	1994	A positive correlation was found between serum creatinine levels and excretion of the tubular enzyme beta NAG (r = 0.36; p < 0.05), but not between creatinine levels and alpha 1-MG or the glomerular markers.	Creatinine	47-57	N-acetyl-alpha-glucosaminidase	Homo sapiens	106-109
7988037-5	1994	This EIA system revealed that the amount of pS2-like immunoreactivity (LI) in human urine was 13.6 ng/mg creatinine (median, n = 416) and that there was no correlation between the pS2-LI concentration in urine and sex or aging.	Creatinine	105-115	taste 2 receptor member 64 pseudogene	Homo sapiens	44-47
7949538-9	1994	The erythropoietin peak appeared to be efficient only when creatinine at the time of the peak was under 200 mumol/l according to the inhibition of erythropoiesis during renal failure.	Creatinine	59-69	erythropoietin	Homo sapiens	4-18
7981655-3	1994	The urinary excretion of urea and creatinine is increased following TNF treatment.	Creatinine	34-44	tumor necrosis factor	Rattus norvegicus	68-71
8015825-4	1994	The NAG values obtained with each substrate decreased with age as a result of a concomitant rise in the urinary creatinine concentration.	Creatinine	112-122	N-acetyl-alpha-glucosaminidase	Homo sapiens	4-7
7520380-4	1994	Urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after, and 2 weeks after cis-platinum treatment was significantly higher than before cis-platinum.	Creatinine	43-53	endothelin 1	Homo sapiens	8-20
7520380-7	1994	Among the four parameters, urinary endothelin-1-like immunoreactivity/creatinine showed the highest level after cis-platinum treatment.	Creatinine	70-80	endothelin 1	Homo sapiens	35-47
8074908-8	1994	In the 12 months before treatment with growth hormone, mean creatinine clearance decreased from 19.3 mL/min per 1.73 m2 to 16.7 mL/min per 1.73 m2.	Creatinine	60-70	growth hormone 1	Homo sapiens	39-53
8181289-0	1994	Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome: correlation with plasma creatinine values.	Creatinine	119-129	tumor necrosis factor	Homo sapiens	43-64
8181289-11	1994	CONCLUSIONS: In the population studied, plasma-soluble TNF receptor concentrations correlated with outcome as well as with plasma creatinine concentrations.	Creatinine	130-140	tumor necrosis factor	Homo sapiens	55-58
8189461-7	1994	Interleukin 6 levels correlated positively with protein turnover (phenylalaninemia) and catabolism (3-methylhistidine/creatinine ratio) and negatively with levels of fibronectin and transthyretin.	Creatinine	118-128	interleukin 6	Homo sapiens	0-13
7974726-7	1994	There was a strong correlation between serum creatinine and plasma TNF-sR55 (r = 0.7, P < 0.001) and TNF-sR75 (r = 0.7, P < 0.001), but not with TNF alpha.	Creatinine	45-55	tumor necrosis factor	Homo sapiens	67-70
7974726-7	1994	There was a strong correlation between serum creatinine and plasma TNF-sR55 (r = 0.7, P < 0.001) and TNF-sR75 (r = 0.7, P < 0.001), but not with TNF alpha.	Creatinine	45-55	tumor necrosis factor	Homo sapiens	151-160
8310408-7	1994	Anti-ET-1 antibody administration (5 nmol/kg body, four times intravenously) decreased plasma creatinine concentration and BUN level and increased urine volume and urinary sodium excretion 3 hours after endotoxin injection (creatinine, p = 0.07; BUN, p < 0.05; urine volume, p < 0.01; urinary sodium excretion, p < 0.01; anti-ET-1 vs shams).	Creatinine	94-104	endothelin 1	Rattus norvegicus	5-9
8310408-7	1994	Anti-ET-1 antibody administration (5 nmol/kg body, four times intravenously) decreased plasma creatinine concentration and BUN level and increased urine volume and urinary sodium excretion 3 hours after endotoxin injection (creatinine, p = 0.07; BUN, p < 0.05; urine volume, p < 0.01; urinary sodium excretion, p < 0.01; anti-ET-1 vs shams).	Creatinine	224-234	endothelin 1	Rattus norvegicus	5-9
8181249-2	1994	Creatinine excretion was 55% higher in men than women (geometric mean 8.9 mumol min-1 (95% confidence limits 4.7-17.0) compared with 5.7 (3.0-10.9); p < 0.001).	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
8181249-5	1994	Likewise, the relationship between AER and albumin:creatinine ratio differed between men and women such that a ratio of 4.0 mg mmol-1 corresponded to a predicted AER of 35 micrograms min-1 in men and 23 micrograms min-1 in women.	Creatinine	51-61	CD59 molecule (CD59 blood group)	Homo sapiens	183-188
8026916-3	1994	Despite elevated basal BE level, that correlated positively with serum creatinine, uraemic patients showed a normal BE secretory pattern.	Creatinine	71-81	proopiomelanocortin	Homo sapiens	23-25
8126998-6	1994	The NPCR was significantly correlated with normalized models of dialysis adequacy including KT/V (urea), total weekly creatinine clearance and the dialysis index.	Creatinine	118-128	nasopharyngeal carcinoma-related protein	Homo sapiens	4-8
7930960-6	1994	Serum MDA correlated with gamma-glutamyl transpeptidase (GGT), while PLA2 correlated with alanine-phosphodiesterase (ALP), GGT, alanine-aminotransferase (ALT) and creatinine.	Creatinine	163-173	phospholipase A2 group IB	Homo sapiens	69-73
7845322-7	1994	An asymptomatic increase in serum creatinine in patients administered ACE inhibitors should raise the possibility of RAS; however, more common renal diseases should be considered.	Creatinine	34-44	angiotensin I converting enzyme	Homo sapiens	70-73
7800207-2	1994	The mean creatinine clearance at the beginning of the study was 89 +/- 13 ml/min/1.73 m2 in patients with type I and 81 +/- 6 ml/min/1.73 m2 in those with type II diabetes.	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
7885789-2	1994	The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients.	Creatinine	126-136	interleukin 6	Homo sapiens	10-14
7885789-2	1994	The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients.	Creatinine	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
8165642-5	1994	When the patients were stratified according to creatinine clearance rate, significant differences between the subgroups with severely and moderately impaired renal function were noted: the baseline levels of PAI activity and VWF were higher in patients with severe renal failure and the VWF response to DDAVP was significantly lower.	Creatinine	47-57	von Willebrand factor	Homo sapiens	287-290
8111177-9	1993	In six patients with a mean observation period of 14 months before and 16 months after the start of EPO, the mean slope of the reciprocal serum creatinine concentration curve improved slightly (p = 0.05).	Creatinine	144-154	erythropoietin	Homo sapiens	100-103
8279220-8	1993	Serum alkaline phosphatase remained unchanged (187.8 U/l vs 186.9 U/l, NS) but serum osteocalcin demonstrated a significant rise (3.94 nmol/l vs 10.53 nmol/l, p < 0.001), parallel to changes in the hydroxyproline/creatinine ratio (19.2 molar ratio x 10(-3) vs 25.2 molar ratio x 10(-3), p < 0.001).	Creatinine	216-226	bone gamma-carboxyglutamate protein	Homo sapiens	85-96
8111143-2	1993	Data suggest insulin-like growth factor 1 (IGF-1) can increase creatinine clearance in healthy humans.	Creatinine	63-73	insulin like growth factor 1	Homo sapiens	13-41
8111143-2	1993	Data suggest insulin-like growth factor 1 (IGF-1) can increase creatinine clearance in healthy humans.	Creatinine	63-73	insulin like growth factor 1	Homo sapiens	43-48
8212212-7	1993	Serum creatinine was higher in CTR (159 +/- 52 mumol/L) than in LTR (117 +/- 24.7, P < 0.05) and values in both groups were above controls (83 +/- 14.1, P < 0.05).	Creatinine	6-16	calcitonin receptor	Homo sapiens	31-34
7923434-4	1993	It was demonstrated that ET-1 correlated negatively to PaO2 and PH and correlated positively to PaCO2 and blood creatinine.	Creatinine	112-122	endothelin 1	Homo sapiens	25-29
8358985-3	1993	In SLE patients, hANP levels correlated with serum creatinine concentration and the patients with proteinuria showed high levels of hANP.	Creatinine	51-61	natriuretic peptide A	Homo sapiens	17-21
8041965-4	1994	The creatinine clearance (mean +/- SD) of the patients was 81 +/- 6 mL/min/1.73 m2 at the beginning of the study.	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
8301063-3	1993	In patients with cirrhosis ET-1 was directly correlated to serum creatinine (r = 0.70, P < 0.0001) and aspartate aminotransferase (r = 0.44, P < 0.03) and negatively correlated to serum sodium (r = -0.58, P < 0.003).	Creatinine	65-75	endothelin 1	Homo sapiens	27-31
8338046-4	1993	Multiple-regression analysis identified serum creatinine as the strongest predictor variable for serum PTH (multiple r = 0.73, P < 0.001).	Creatinine	46-56	parathyroid hormone	Homo sapiens	103-106
7902884-5	1993	Blood urea nitrogen and serum creatinine were significantly elevated in rats with anti-Thy 1 nephritis at weeks 4 and 6 compared to normal rats.	Creatinine	30-40	Thy-1 cell surface antigen	Rattus norvegicus	87-92
8501150-5	1993	Urinary hydroxyproline/creatinine excretion was increased in all except 1 patient and correlated with plasma IGF-I levels (r = 0.49; P < 0.02; n = 22).	Creatinine	23-33	insulin like growth factor 1	Homo sapiens	109-114
8361034-6	1993	5) Among DM patients with nephropathy the correlation was present between s-SOD activities and levels of creatinine.	Creatinine	105-115	superoxide dismutase 1	Homo sapiens	76-79
8465834-8	1993	Comparisons of randomized groups in the MRFIT or TOMHS did not demonstrate improved renal function with more aggressive BP lowering, but in MRFIT average on-treatment DBP < 95 mm Hg was associated with more favorable slopes of reciprocal creatinine.	Creatinine	241-251	D-box binding PAR bZIP transcription factor	Homo sapiens	167-170
8257476-9	1993	These toxicities were accompanied by increases in hepatocellular enzymes and creatinine previously described with IL-2.	Creatinine	77-87	interleukin 2	Homo sapiens	114-118
8327642-9	1993	There was significant correlation between serum creatinine and systolic blood pressure at time of biopsy (p = 0.01) and between serum creatinine and serum albumin (p = 0.001).	Creatinine	134-144	albumin	Homo sapiens	155-162
8468114-6	1993	Only one patient (BID group) showed a rise of serum creatinine during the observation period.	Creatinine	52-62	BH3 interacting domain death agonist	Homo sapiens	18-21
1582013-5	1992	In healthy individuals (ages 20-80 years) the IAP concentrations, expressed as urinary creatinine ratios, ranged from 0.1 to 2.0 U/g (5-95 percentiles) without major differences related to sex and age.	Creatinine	87-97	alkaline phosphatase, intestinal	Homo sapiens	46-49
8452322-0	1993	Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients.	Creatinine	83-93	angiotensin I converting enzyme	Homo sapiens	32-61
8452322-16	1993	CONCLUSIONS: In normotensive patients with diabetes mellitus type II, the institution of angiotensin-converting enzyme inhibition during early stages of diabetic nephropathy results in long-term stabilization of plasma creatinine levels and of the degree of urinary loss of albumin.	Creatinine	219-229	angiotensin I converting enzyme	Homo sapiens	89-118
8289999-4	1993	Plasma levels of BNP correlated significantly with urinary protein excretion (UPrV) and urinary protein/creatinine ratio (UPrV/UcrV).	Creatinine	104-114	natriuretic peptide B	Rattus norvegicus	17-20
8399651-6	1993	Total weekly creatinine clearances correlated with NPCR (r = 0.59; p < 0.0002), which supports the hypothesis that dietary protein intake is dependent on the delivered dialysis dose.	Creatinine	13-23	nasopharyngeal carcinoma-related protein	Homo sapiens	51-55
1294957-1	1992	This study of serum erythropoietin levels and reticulocytes counts in the first month after kidney transplantation shows that the erythropoietin peak is efficient only when serum creatinine level at the time of the peak is under 200 mumol/l.	Creatinine	179-189	erythropoietin	Homo sapiens	130-144
1283730-11	1992	The mean change in serum creatinine following IGF-I (-6.3 +/- 3.0 mmol/l) was significantly different from that in the control group (+7.2 +/- 6.2, P = 0.03).	Creatinine	25-35	insulin like growth factor 1	Homo sapiens	46-51
1283730-12	1992	Creatinine clearance rose from a mean of 71.6 +/- 7.5 ml/min to 83.2 +/- 7.6 ml/min after IGF-I treatment (P = 0.02).	Creatinine	0-10	insulin like growth factor 1	Homo sapiens	90-95
1468818-2	1992	Men with a urinary albumin:creatinine ratio above the 90th percentile had higher systolic and diastolic blood pressures, fasting plasma glucose, 2-h glucose after a 75 g oral glucose load, and fasting serum insulin.	Creatinine	27-37	insulin	Homo sapiens	207-214
1468818-3	1992	Women with high urinary albumin:creatinine values had higher systolic and diastolic blood pressures, body mass index, waist-hip ratio, fasting insulin and triglycerides.	Creatinine	32-42	insulin	Homo sapiens	143-150
1468818-4	1992	Multivariate analysis showed that only systolic blood pressure and fasting glucose in men, and diastolic blood pressure and fasting insulin in women, independently contributed to urinary albumin:creatinine.	Creatinine	195-205	insulin	Homo sapiens	132-139
1468818-5	1992	When the effect of blood pressure was eliminated by excluding subjects with systolic blood pressure > 140 and diastolic > 90 mm Hg, only fasting insulin was associated with urinary albumin:creatinine in women.	Creatinine	195-205	insulin	Homo sapiens	151-158
1472664-4	1992	Preoperative plasma ANP did not correlate with hemodynamics, but was negatively correlated with creatinine clearance (r = -0.76, P < .01).	Creatinine	96-106	natriuretic peptide A	Homo sapiens	20-23
1472664-7	1992	Postoperative plasma ANP was not correlated with hemodynamics, but was negatively correlated with both creatinine clearance (r = -0.65, P < .05) and content of ANP in the native atria (r = -0.75, P < .01).	Creatinine	103-113	natriuretic peptide A	Homo sapiens	21-24
1451221-7	1992	Creatinine clearance was increased by hANP infusion, but did not change in the nicardipine group.	Creatinine	0-10	natriuretic peptide A	Homo sapiens	38-42
1424122-9	1992	The correlation of serum Cg A to creatinine and parathyroid hormone is described.	Creatinine	33-43	chromogranin A	Homo sapiens	25-29
1393477-4	1992	A positive correlation was found (r = 0.66, P < 0.001) between the highest serum PLA2 activity, as measured early in the course of acute pancreatitis, and the highest N-acetyl-beta-glucosaminidase (NAG):creatinine ratio in the urine.	Creatinine	206-216	phospholipase A2 group IB	Homo sapiens	84-88
1393477-5	1992	The correlation between the highest serum concentration of immunoreactive pancreatic PLA2 and the highest urinary NAG:creatinine ratio was weaker (r = 0.36, P < 0.05).	Creatinine	118-128	phospholipase A2 group IB	Homo sapiens	85-89
1355071-1	1992	A novel NcoI polymorphism has been detected in the 3" untranslated region of the creatinine kinase (CKM) gene.	Creatinine	81-91	creatine kinase, M-type	Homo sapiens	100-103
1639950-12	1992	IN CONCLUSION: elderly patients with normal serum creatinine had a small (+30%) but significant increase in intact serum PTH concentration but the mean concentration still remained within the normal range.	Creatinine	50-60	parathyroid hormone	Homo sapiens	121-124
8105967-1	1993	The creatinine generation was measured (GCr) in 132 continuous ambulatory peritoneal dialysis (CAPD) patients from the product of total daily peritoneal plus renal creatinine clearance and plasma creatinine (CpCr) plus the product of estimated gut clearance of 0.036 L/kg/day and CpCr.	Creatinine	4-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	40-43
8277359-3	1993	In healthy volunteers (age 20-55 years), the mean value of the PSP concentration, expressed as ratios to urine creatinine, was 129 +/- 88 (mean +/- SD) micrograms/g without any differences for sex.	Creatinine	111-121	regenerating family member 1 alpha	Homo sapiens	63-66
8094434-3	1993	The median urinary concentration of growth hormone in the stunted children with chronic inflammatory bowel disease was 15.8 ng/g creatinine (range 4.3-32.6), compared with 11.7 ng/g creatinine (range 4.1-35.9) in those with normal growth.	Creatinine	129-139	growth hormone 1	Homo sapiens	36-50
8468935-5	1993	Comparison of clinical data showed that patients who expressed 5-LO and FLAP had a lower glomerular filtration rate and an increased level of blood urea nitrogen, serum creatinine, and proteinuria.	Creatinine	169-179	arachidonate 5-lipoxygenase activating protein	Homo sapiens	72-76
8390011-10	1993	Circulating GH and GH-BP activity were influenced by serum creatinine and haematocrit.	Creatinine	59-69	growth hormone 1	Homo sapiens	12-14
8333281-9	1993	The change of ANF levels was positively correlated with the body weight change and creatinine change after HD.	Creatinine	83-93	natriuretic peptide A	Homo sapiens	14-17
1478191-3	1992	There was a positive correlation (r = 0.785, P < 0.001) between IGF-I values in early morning urine and those of 24 h urine when they were corrected by urinary Cr.	Creatinine	163-165	insulin like growth factor 1	Homo sapiens	67-72
1281137-3	1992	Significantly higher levels of maternal serum AFP were found in 101 women who had more than 1.0 microgram cotinine/mg urinary creatinine compared with 180 women whose urinary cotinine levels were below this level [(mean +/- SD) 1.23 +/- 0.64 and 1.06 +/- 0.54 respectively; 95 per cent CI of difference of means 0.01-0.31; P < 0.05].	Creatinine	126-136	alpha fetoprotein	Homo sapiens	46-49
1456082-5	1992	In young men, there were unexpected but significant associations between lower femoral neck BMD and higher serum osteocalcin and urinary calcium/creatinine excretion after age adjustment.	Creatinine	145-155	bone gamma-carboxyglutamate protein	Homo sapiens	113-124
1431569-7	1992	Despite finding no correlation between serum apoA-IV and triglyceride levels (in either the d less than 1.006 g/ml or 1.006 less than d less than 1.019 g/ml fraction), serum apoA-IV was positively correlated with the renal function parameters of blood urea nitrogen (r = 0.949, P less than 0.001), creatinine (r = 0.952, P less than 0.001), and uric acid (r = 0.903, P less than 0.001).	Creatinine	298-308	apolipoprotein A4	Rattus norvegicus	174-181
1526365-10	1992	Furthermore, Ca2+ channel blockers markedly inhibited increases in the serum urea nitrogen and creatinine concentrations and development of the tubular necrosis and the lesions of the arterial walls, which were induced by DQ-2556.	Creatinine	95-105	carbonic anhydrase 2	Rattus norvegicus	13-16
1578305-0	1992	Effect of growth hormone treatment on serum creatinine concentration in patients with cystinosis and chronic renal disease.	Creatinine	44-54	growth hormone 1	Homo sapiens	10-24
1578305-1	1992	Three patients with nephropathic cystinosis and chronic renal disease, treated since early childhood with orally administered cysteamine, had an accelerated rate of rise of serum creatinine values after receiving recombinant human growth hormone.	Creatinine	179-189	growth hormone 1	Homo sapiens	231-245
1578305-3	1992	The slope of the plot of reciprocal serum creatinine values versus age for each patient after growth hormone treatment was significantly steeper than the pretreatment slope.	Creatinine	42-52	growth hormone 1	Homo sapiens	94-108
1374948-12	1992	These data suggest that the release of TNF may be responsible for the increasing of BUN and creatinine levels seen after renal I/R and that pretreatment of renal donors with FK506 may improve renal function in the immediate post-transplant period.	Creatinine	92-102	tumor necrosis factor	Rattus norvegicus	39-42
1735820-5	1992	During growth hormone treatment, serum creatinine concentration rose from 140 +/- 50 to 190 +/- 80 mumol/L (1.6 +/- 0.6 to 2.1 +/- 0.9 mg/dl) (p less than 0.05), and creatinine clearances decreased from 0.79 +/- 0.37 to 0.58 +/- 0.30 ml/sec per 1.73 m2 (47 +/- 22 to 35 +/- 18 ml/min per 1.73 m2) (p less than 0.05) but then remained stable.	Creatinine	39-49	growth hormone 1	Homo sapiens	7-21
1482257-6	1992	As compared to normotensives and hypertensives with normal IGF-I levels, patients with increased IGF-I levels were characterized by lower (P < 0.01) fractional Na+ excretion and higher (P < 0.05) creatinine clearance.	Creatinine	202-212	insulin like growth factor 1	Homo sapiens	97-102
1330455-3	1992	The serum EDF concentration was significantly elevated with decrease of renal function and was positively correlated with the levels of BUN and blood creatinine.	Creatinine	150-160	inhibin subunit beta A	Homo sapiens	10-13
1596306-5	1992	Multiple regression analysis revealed that age, gender, systolic blood pressure and insulin resistance independently accounted for 37% of the variability in albumin/creatinine ratios.	Creatinine	165-175	insulin	Homo sapiens	84-91
1546024-9	1992	Elevation in the serum creatinine level of a patient taking an angiotensin-converting enzyme (ACE) inhibitor suggests bilateral renovascular hypertension.	Creatinine	23-33	angiotensin I converting enzyme	Homo sapiens	63-92
1546024-9	1992	Elevation in the serum creatinine level of a patient taking an angiotensin-converting enzyme (ACE) inhibitor suggests bilateral renovascular hypertension.	Creatinine	23-33	angiotensin I converting enzyme	Homo sapiens	94-97
1735820-7	1992	Growth hormone treatment may be useful as adjunctive therapy for increasing growth rates in selected children with renal allografts who have poor growth; however, serum creatinine concentrations should be closely monitored during such treatment.	Creatinine	169-179	growth hormone 1	Homo sapiens	0-14
1735820-5	1992	During growth hormone treatment, serum creatinine concentration rose from 140 +/- 50 to 190 +/- 80 mumol/L (1.6 +/- 0.6 to 2.1 +/- 0.9 mg/dl) (p less than 0.05), and creatinine clearances decreased from 0.79 +/- 0.37 to 0.58 +/- 0.30 ml/sec per 1.73 m2 (47 +/- 22 to 35 +/- 18 ml/min per 1.73 m2) (p less than 0.05) but then remained stable.	Creatinine	166-176	growth hormone 1	Homo sapiens	7-21
1735820-6	1992	Growth rates of two patients returned to pretreatment rates when growth hormone treatment was discontinued after 5 and 7 months because of increased serum creatinine values.	Creatinine	155-165	growth hormone 1	Homo sapiens	65-79
1539484-7	1992	Creatinine clearances per 1.73 m2 body surface area (CCreat) in Group I were 78 +/- 14 ml.min-1, and in Group II 78 +/- 11 ml.min-1 before hypotension.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	90-95
1415281-9	1992	Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week.	Creatinine	43-53	chorionic somatomammotropin hormone 2	Homo sapiens	117-120
1739346-5	1992	In the prepubertal children (n = 17), in both groups 1 and 2, there was a significant correlation between mean serum growth hormone and total uGHng/g creatinine.	Creatinine	150-160	growth hormone 1	Homo sapiens	117-131
1739346-6	1992	There were also significant correlations between total uGHng/g creatinine and both peak serum growth hormone and mean amplitude of the pulses in the growth hormone profile.	Creatinine	63-73	growth hormone 1	Homo sapiens	94-108
1739346-6	1992	There were also significant correlations between total uGHng/g creatinine and both peak serum growth hormone and mean amplitude of the pulses in the growth hormone profile.	Creatinine	63-73	growth hormone 1	Homo sapiens	149-163
1739346-8	1992	In group 3 there were significant correlations between total uGHng/g creatinine and both the mean serum growth hormone and mean amplitude of the pulses in the profile.	Creatinine	69-79	growth hormone 1	Homo sapiens	104-118
1539484-7	1992	Creatinine clearances per 1.73 m2 body surface area (CCreat) in Group I were 78 +/- 14 ml.min-1, and in Group II 78 +/- 11 ml.min-1 before hypotension.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
1618252-3	1992	For women the creatinine clearance (ml.min-1) was [150-(years)].body weight (kg)/serum creatinine (mumol.l-1).	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
1600330-4	1992	There were significant inverse correlations of plasma C-peptide, GIP, and gastrin immunoreactivity to endogenous creatinine clearance (kidney function).	Creatinine	113-123	insulin	Homo sapiens	54-63
1618252-3	1992	For women the creatinine clearance (ml.min-1) was [150-(years)].body weight (kg)/serum creatinine (mumol.l-1).	Creatinine	87-97	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
1309855-7	1992	Comparison of 78 plasma samples collected during 26 episodes of biopsy-proven acute cellular rejection with samples collected during periods of stable renal function (n = 349) showed that TNF levels rose significantly (390 +/- 242 pg/ml, p less than 0.01) above background levels 3 days before rising serum creatinine concentrations, and peaked (2,426 +/- 978 pg/ml) on the day of clinical rejection.	Creatinine	307-317	tumor necrosis factor	Homo sapiens	188-191
1451711-7	1992	Creatinine clearance was 13.2 (95% CI 6.0 to 20.4) ml.min-1 lower in users than non-users of non-aspirin non-steroidal anti-inflammatory drugs.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
1778109-2	1991	The corrected value calculated as 24 h-UCP/(urinary C-peptide to creatinine clearance (CCP/CCR) ratio in the fasting state x 10) was correlated with the sum of day-long serum C-peptide levels (r = 0.93) more closely than the measured value of 24 h-UCP (r = 0.79) in 9 patients.	Creatinine	65-75	insulin	Homo sapiens	175-184
1306570-5	1992	Basel serum BE concentration was significantly higher in patients with CRF than in healthy subjects and correlation positively with creatinine.	Creatinine	132-142	proopiomelanocortin	Homo sapiens	12-14
1918399-4	1991	In both antibiotic groups increases in prothrombin time were more likely following surgery and in patients who were older, with a high platelet count, low albumin, or higher urea and creatinine concentrations.	Creatinine	183-193	coagulation factor II, thrombin	Homo sapiens	39-50
1308626-8	1992	The NAG: creatinine ratio was shown to be elevated after 2 days of treatment at 63 mg/kg.	Creatinine	9-19	N-acetyl-alpha-glucosaminidase	Homo sapiens	4-7
1951337-4	1991	The D/P creatinine (Cr) at 4 hours was also significantly reduced in the patients on EPO at 3 (.70 +/- .1), 6 (.66 +/- .12) months when compared with baseline (.76 +/- .11).	Creatinine	8-18	erythropoietin	Homo sapiens	85-88
1951337-4	1991	The D/P creatinine (Cr) at 4 hours was also significantly reduced in the patients on EPO at 3 (.70 +/- .1), 6 (.66 +/- .12) months when compared with baseline (.76 +/- .11).	Creatinine	20-22	erythropoietin	Homo sapiens	85-88
1756686-2	1991	Urinary C-peptide clearance expressed as the ratio of urinary C-peptide to creatinine clearance (CCP/CCR) in the fasting state did not differ in control subjects and RD patients, and was higher equally in NIDDM patients with and without proteinuria.	Creatinine	75-85	insulin	Homo sapiens	8-17
1762297-2	1991	A highly significant correlation was found between urinary albumin and transferrin excretion over a wide range of urinary albumin excretion (0.005 to 18 g/g creatinine) (r = 0.972).	Creatinine	157-167	albumin	Homo sapiens	59-66
1762297-2	1991	A highly significant correlation was found between urinary albumin and transferrin excretion over a wide range of urinary albumin excretion (0.005 to 18 g/g creatinine) (r = 0.972).	Creatinine	157-167	transferrin	Homo sapiens	71-82
1762297-2	1991	A highly significant correlation was found between urinary albumin and transferrin excretion over a wide range of urinary albumin excretion (0.005 to 18 g/g creatinine) (r = 0.972).	Creatinine	157-167	albumin	Homo sapiens	122-129
1762297-8	1991	In patients with both subnephrotic and nephrotic range proteinuria, approximately 35 to 40 micrograms Fe/g creatinine was present in the urine with an excess of transferrin.	Creatinine	107-117	transferrin	Homo sapiens	161-172
1914227-9	1991	The patients with IL-6 in the urine had a mean serum creatinine significantly higher than those without IL-6.	Creatinine	53-63	interleukin 6	Homo sapiens	18-22
1761280-6	1991	The results demonstrated that creatinine, creatine and glycocyamine have a direct suppressive effect on insulin binding of postdialyzed plasma (p less than 0.05) in concentration of 1 mmol/l.	Creatinine	30-40	insulin	Homo sapiens	104-111
1893640-5	1991	Side effects believed to be related to the pharmacologic action of ACE inhibitors as a class include symptomatic hypotension, which occurred at a relatively low rate with benazepril, and hyperkalemia and elevation of serum creatinine, which occurred to the same extent with benazepril as has been noted with other ACE inhibitors.	Creatinine	223-233	angiotensin I converting enzyme	Homo sapiens	67-70
1720421-2	1991	Amylase to creatinine clearance (Cam/Ccr) was studied in 17 normals and 14 patients with renal failure, 10 benign and 4 with malignant diseases.	Creatinine	11-21	calmodulin 3	Homo sapiens	33-36
1683549-8	1991	The creatinine clearance was 48.2 +/- 17.4 ml min-1 (mean +/- s.d.).	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	46-51
1919393-7	1991	In UOX sheep with plasma creatinine levels in the range 100-440 mumol/l, there was a linear relationship between osteocalcin PCR and ERPF; the osteocalcin RCR was related to the osteocalcin PCR (RCR = 0.9 x PCR - 0.50).	Creatinine	25-35	osteocalcin	Ovis aries	113-124
1919393-7	1991	In UOX sheep with plasma creatinine levels in the range 100-440 mumol/l, there was a linear relationship between osteocalcin PCR and ERPF; the osteocalcin RCR was related to the osteocalcin PCR (RCR = 0.9 x PCR - 0.50).	Creatinine	25-35	osteocalcin	Ovis aries	143-154
1919393-7	1991	In UOX sheep with plasma creatinine levels in the range 100-440 mumol/l, there was a linear relationship between osteocalcin PCR and ERPF; the osteocalcin RCR was related to the osteocalcin PCR (RCR = 0.9 x PCR - 0.50).	Creatinine	25-35	osteocalcin	Ovis aries	143-154
1794250-6	1991	(5) CD 4/CD 8 was negatively correlated with the serum creatinine level (r = -0.524).	Creatinine	55-65	CD4 molecule	Homo sapiens	4-8
1921154-2	1991	We now report that the administration of anti-TNF antiserum to rats with the AA-NTSN reduces albuminuria in a dose related manner (day 8 postinduction) and limits glomerular necrosis (P less than 0.05) without affecting the endogenous creatinine clearance (CCr).	Creatinine	235-245	tumor necrosis factor	Rattus norvegicus	46-49
1904959-4	1991	High values just before onset of rejection (increase of serum creatinine value), deterioration at onset phase and gradual elevation from peak phase toward recovery phase were observed in urinary tPA of 6 reversible acute rejection episodes.	Creatinine	62-72	plasminogen activator, tissue type	Homo sapiens	195-198
1998407-3	1991	In septic patients elevated plasma concentrations of endothelin-1 were inversely correlated with cardiac index (r = -0.80, p less than 0.005) and positively correlated the severity of illness as documented by APACHE II score (r = 0.74, p less than 0.01) and plasma creatinine levels (r = 0.80, p less than 0.005).	Creatinine	265-275	endothelin 1	Homo sapiens	53-65
1900537-6	1991	The excretion of C-peptide was elevated to three times the normal both in absolute terms and when normalized to creatinine excretion.	Creatinine	112-122	insulin	Homo sapiens	17-26
2044224-4	1991	IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin.	Creatinine	239-249	interleukin 6	Homo sapiens	0-4
2042807-1	1991	We have studied 122 patients, all younger than 12 months of age, to whom we check the N-acetylglucosaminidase/creatinine (NAG/creatinine) ratio in the first morning urine.	Creatinine	110-120	N-acetyl-alpha-glucosaminidase	Homo sapiens	122-125
2042807-3	1991	The NAG/creatinine values were inversely correlated with age, height and weight.	Creatinine	8-18	N-acetyl-alpha-glucosaminidase	Homo sapiens	4-7
1842557-8	1991	Slight decreases in serum insulin, uric acid, and creatinine were observed after the seventh administration of IGF-I.	Creatinine	50-60	insulin like growth factor 1	Homo sapiens	111-116
1992932-5	1991	Bone Gla-protein also correlated significantly with urinary beta 2-microglobulin in the men and with serum creatinine in the women.	Creatinine	107-117	bone gamma-carboxyglutamate protein	Homo sapiens	0-16
1996485-3	1991	However, patients with markedly elevated serum creatinine levels (6.0 to 14.0 mg/dL [530-1240 mumol/L]) had a significantly greater average hemoglobin loss (-0.82 +/- 1.3 g/dL [-8 +/- 13 g/L], n = 11) than patients with normal serum creatinine levels (-0.12 +/- 0.88 g/dL [-1 +/- 9 g/L], n = 450) (p = 0.011).	Creatinine	47-57	l(1)2Fd	Drosophila melanogaster	173-199
1906396-3	1991	Throughout the whole period a correlation (r = -0.65, P less than 0.05) was found between the CD4+/CD8+ ratio and serum, creatinine.	Creatinine	121-131	CD4 molecule	Homo sapiens	94-97
2050182-2	1991	There was a high correlation between the measured and predicted creatinine clearance as shown by the regression equation: measured creatinine clearance = 0.84 predicted creatinine clearance +4.5 ml.min-1 (r2 = 0.74).	Creatinine	64-74	CD59 molecule (CD59 blood group)	Homo sapiens	198-203
1815970-6	1991	In uraemic patients, Cmax and tmax were slightly increased and t1/2 was increased to 12-14 h in patients with an endogenous creatinine clearance below 20 ml.min-1.	Creatinine	124-134	CD59 molecule (CD59 blood group)	Homo sapiens	157-162
2050182-2	1991	There was a high correlation between the measured and predicted creatinine clearance as shown by the regression equation: measured creatinine clearance = 0.84 predicted creatinine clearance +4.5 ml.min-1 (r2 = 0.74).	Creatinine	131-141	CD59 molecule (CD59 blood group)	Homo sapiens	198-203
2050182-2	1991	There was a high correlation between the measured and predicted creatinine clearance as shown by the regression equation: measured creatinine clearance = 0.84 predicted creatinine clearance +4.5 ml.min-1 (r2 = 0.74).	Creatinine	131-141	CD59 molecule (CD59 blood group)	Homo sapiens	198-203
1830872-5	1991	Per cent and absolute changes in plasma ANP level correlated significantly with concomitant changes in body weight (r = 0.764; p less than 0.001 and r = 0.558; p less than 0.01, resp.) but not with changes in serum creatinine, blood pressure or serum electrolytes.	Creatinine	215-225	natriuretic peptide A	Homo sapiens	40-43
2339855-8	1990	In patients with alcoholic hepatitis, tumor necrosis factor levels correlated positively with serum bilirubin (r = 0.74; P = 0.0009) and serum creatinine (r = 0.81; P = 0.0003).	Creatinine	143-153	tumor necrosis factor	Homo sapiens	38-59
1779936-6	1991	iPTH and osteocalcin were positively correlated with serum creatinine, osteoblast surface and the eroded surface, but did not correlate with IGF-1.	Creatinine	59-69	bone gamma-carboxyglutamate protein	Homo sapiens	9-20
2151149-1	1990	The aim of the study was the search for the correlation between the degree of impairment renal function (measured by creatinine clearance) and plasma concentration of atrial natriuretic peptide (ANP) and urinary fractional sodium excretion (FENa) in patients with chronic renal diseases.	Creatinine	117-127	natriuretic peptide A	Homo sapiens	167-193
2151149-1	1990	The aim of the study was the search for the correlation between the degree of impairment renal function (measured by creatinine clearance) and plasma concentration of atrial natriuretic peptide (ANP) and urinary fractional sodium excretion (FENa) in patients with chronic renal diseases.	Creatinine	117-127	natriuretic peptide A	Homo sapiens	195-198
2127316-6	1990	In the anaemic MM patients with severe renal failure (S-creatinine levels greater than 400 mumol/l) the compensatory secretion of EPO was inadequate in relation to the degree of anaemia.	Creatinine	56-66	erythropoietin	Homo sapiens	130-133
1793103-3	1991	This study reports on the relationship of PCE in breath and estimates of chronic exposure with the urinary ratios of total urinary protein, albumin, and n-acetyl-glucosaminidase (NAG) to creatinine in dry cleaning workers exposed to PCE.	Creatinine	187-197	N-acetyl-alpha-glucosaminidase	Homo sapiens	179-182
1977540-5	1990	In those diabetic subjects with clinical retinopathy only Alb/Cr ratio was higher.	Creatinine	62-64	albumin	Homo sapiens	58-61
2379384-7	1990	Mean clearance in two patients with creatinine clearance values greater than 150 ml/min/1.73 m2 was 17.7 L/hr/1.73 m2.	Creatinine	36-46	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
2379384-8	1990	Mean clearance in two patients with creatinine clearance values less than 50 ml/min/1.73 m2 was 8.5 L/hr/1.73 m2.	Creatinine	36-46	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
2379384-10	1990	Creatinine clearance ranged from 17 to 218 ml/min/1.73 m2.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	46-51
2380336-7	1990	Only in men was there a significant but modest inverse relationship between creatinine clearance and PTH (r = -0.212; P less than 0.05), which was multicollinear with age.	Creatinine	76-86	parathyroid hormone	Homo sapiens	101-104
2143594-2	1990	The existence of tissue renin angiotensin system (RAS) has been widely suggested in the recent literature by 2 main approaches: first, a dissociation between antihypertensive effects of angiotensin converting enzyme (ACE) inhibitors and the levels of stimulation of the circulating RAS; secondly, by the demonstration of the presence of the 3 key-proteins of the system (angiotensinogen, creatinine, and converting enzyme) within the 3 main target-organs of hypertension (i.e. kidney, heart and vessels).	Creatinine	388-398	renin	Homo sapiens	24-29
2373550-1	1990	Treatment of renal anemia with recombinant human erythropoietin in chronic hemodialysis patients has been reported to lead to increased appetite, and in several studies, to an increase in predialysis serum urea, potassium and creatinine values.	Creatinine	226-236	erythropoietin	Homo sapiens	49-63
2161692-8	1990	Baseline fasting urinary excretion of OH-proline increased during hPTH 1-38 treatment from 30.5 +/- 13.9 mol/mmol creatinine to 43.4 +/- 17.5 immediately after hPTH 1-38 infusion (P less than 0.025), and mean excretion was persistently higher than baseline during intermittent treatment; the increased urine calcium and OH-proline excretion are consistent with PTH-induced activation of bone resorption.	Creatinine	114-124	parathyroid hormone	Homo sapiens	66-72
2161692-8	1990	Baseline fasting urinary excretion of OH-proline increased during hPTH 1-38 treatment from 30.5 +/- 13.9 mol/mmol creatinine to 43.4 +/- 17.5 immediately after hPTH 1-38 infusion (P less than 0.025), and mean excretion was persistently higher than baseline during intermittent treatment; the increased urine calcium and OH-proline excretion are consistent with PTH-induced activation of bone resorption.	Creatinine	114-124	parathyroid hormone	Homo sapiens	67-70
2348646-3	1990	In patients with normal creatinine, a positive correlation was found between parathyroid hormone and age (r = 0.41; P less than 0.01).	Creatinine	24-34	parathyroid hormone	Homo sapiens	77-96
2107743-8	1990	Administration of indomethacin, 50 mg bid, resulted in a significant decrease in 2,3-dinor-6-keto-PGF1 alpha from 65 +/- 6 ng/g to 37 +/- 8 ng/g of creatinine.	Creatinine	148-158	BH3 interacting domain death agonist	Homo sapiens	38-41
2323111-7	1990	Urinary DAP IV activity of healthy controls was 4.94 +/- 0.12 U/l (DCR: 0.46 +/- 0.30 U/mmol creatinine) with only small day to day variations.	Creatinine	93-103	Down syndrome chromosome region	Homo sapiens	67-70
2323111-9	1990	In patients with chronic glomerulonephritis urinary DAP IV activity was 9.6 +/- 5.6 U/l, p less than 0.05 (DCR: 1.22 +/- 0.75 U/mmol creatinine, p less than 0.05 vs controls).	Creatinine	133-143	Down syndrome chromosome region	Homo sapiens	107-110
2405136-5	1990	Mean creatinine clearance was 49.5 +/- 20 ml/min/1.73 m2.	Creatinine	5-15	CD59 molecule (CD59 blood group)	Homo sapiens	45-50
1706805-7	1990	Nevertheless, there was a significant correlation between the decline in arterial pressure and fall in creatinine clearance induced by ACE inhibition (r = 0.65, p less than 0.05), with evidence that drug accumulation may potentiate hypotension and renal impairment should arterial pressure be reduced below the threshold for renal autoregulation.	Creatinine	103-113	angiotensin I converting enzyme	Homo sapiens	135-138
2302775-5	1990	The normal reference interval (mean +/- 2 SD) for NAG: 1.6-15.0 (mean 4.9) U per gram of creatinine.	Creatinine	89-99	N-acetyl-alpha-glucosaminidase	Homo sapiens	50-53
2227126-9	1990	However, after controlling for duration of diabetes, glycosylated hemoglobin, diastolic blood pressure, and the presence of proteinuria and/or creatinine greater than or equal to 265 microM in a multiple logistic regression model, IGF-I was not significantly associated with PDR.	Creatinine	143-153	insulin like growth factor 1	Homo sapiens	231-236
2347659-4	1990	PTH levels were above normal when creatinine clearance was below 45 ml/min in the intact PTH assay and 66 ml/min in the i-PTH assay.	Creatinine	34-44	parathyroid hormone	Homo sapiens	0-3
2405137-6	1990	By standard correlation techniques, there appeared to be an inverse correlation between calculated creatinine clearance and serum osteocalcin concentration, and a direct correlation between serum osteocalcin and parathyroid hormone values.	Creatinine	99-109	bone gamma-carboxyglutamate protein	Homo sapiens	130-141
2301413-5	1990	After logarithmic transformation of the data, the following linear regression equation was found: log (TTCA) = 0.84 log (CS2) - 1.10, wherein TTCA is expressed as mmol/mol creatinine and CS2 as mg/m3.	Creatinine	172-182	chorionic somatomammotropin hormone 2	Homo sapiens	121-124
2350891-7	1990	Measurement of the calcium: creatinine clearance ratio provides a good method of identifying hypercalcaemic patients who might have FHH.	Creatinine	28-38	calcium sensing receptor	Homo sapiens	132-135
2361353-5	1990	Of the remaining patients (normoproteinuria), 25.5% have elevated transferrin (greater than 0.9 mg/g creatinine) while 18.8% have elevated albumin (greater than 32 mg/g creatinine).	Creatinine	101-111	transferrin	Homo sapiens	66-77
2253254-5	1990	A significantly inverse correlation between urinary GH excretion and creatinine clearance was found (r = -0.55; p less than 0.05).	Creatinine	69-79	growth hormone 1	Homo sapiens	52-54
2361354-10	1990	(4) In streptozotocin-induced diabetes, the concentration of albumin and transferrin expressed as milligrams per liter decreases; however, the output/24 h or per gram creatinine is increased with a greater increase in transferrin output relative to that of albumin.	Creatinine	167-177	transferrin	Rattus norvegicus	218-229
2340852-4	1990	Patients whose creatinine clearance was below about 30-40 ml.min-1 were had the highest concentrations.	Creatinine	15-25	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
1688749-2	1990	Urinary transferrin excretion was significantly elevated in diabetic (median (range) 186 (18-1671) mg mol-creatinine-1) compared with normal (85 (27-668) mg mol-creatinine-1) children (p less than 0.001).	Creatinine	106-116	transferrin	Homo sapiens	8-19
1688749-2	1990	Urinary transferrin excretion was significantly elevated in diabetic (median (range) 186 (18-1671) mg mol-creatinine-1) compared with normal (85 (27-668) mg mol-creatinine-1) children (p less than 0.001).	Creatinine	161-171	transferrin	Homo sapiens	8-19
2352577-7	1990	Negative correlations were found between serum FN and the ratio of serum urea to serum creatinine (Surea/Scr) in CAPD and HD patients.	Creatinine	87-97	fibronectin 1	Homo sapiens	47-49
2136743-6	1990	The changes in urinary clearance of AVP in all three experiments occurred even in relation to creatinine clearance.	Creatinine	94-104	arginine vasopressin	Homo sapiens	36-39
2271512-4	1990	The urine plasminogen activator activity correlated with the osmolality (r = 0.51, P less than 0.001) and creatinine (r = 0.56, P less than 0.001) of the urine, suggesting that it is concentrated at distal nephrons.	Creatinine	106-116	plasminogen activator, urokinase	Homo sapiens	4-31
2345589-2	1990	For both insulin-dependent and non-insulin-dependent diabetes, serum creatinine exhibited a more rapid rise in those individuals whose BP remained elevated above 140 mm Hg despite therapy.	Creatinine	69-79	insulin	Homo sapiens	9-16
2345591-4	1990	Median serum creatinine levels in the ACE group rose acutely from 2.33 to 2.7 mg/dl after 1 month of therapy and remained stable thereafter.	Creatinine	13-23	angiotensin I converting enzyme	Homo sapiens	38-41
2138254-9	1990	In these patients there was a highly significant correlation between serum creatinine and plasma ANP concentrations (p less than 0.01; r = 0.75; y = 0.2x + 3).	Creatinine	75-85	natriuretic peptide A	Homo sapiens	97-100
2353535-3	1990	An inverse correlation was found between the FN concentration and other blood biochemical parameters (LDH, creatinine, and urea).	Creatinine	107-117	fibronectin 1	Homo sapiens	45-47
33779452-2	2021	Because the procedure is cumbersome, GFR is estimated (eGFR) using algorithms based on the observed relationship between measured GFR (mGFR) and more accessible biomarkers such as creatinine and cystatin C.	Creatinine	180-190	epidermal growth factor receptor	Homo sapiens	55-59
33767704-4	2021	Here, by using a mouse model of renal ischemia-reperfusion, we found that myeloid cell-specific TSC1 knockout mice (termed Lyz-TSC1 cKO mice) had higher serum creatinine levels, more severe histological damage, and greater proinflammatory cytokine production than wild-type (WT) mice during the early phase after renal ischemia-reperfusion.	Creatinine	159-169	lysozyme 1	Mus musculus	123-126
2403005-4	1990	Urinary GH levels were significantly lower in the eight children with complete GH deficiency (3.1 +/- 2.3 ng/g creatinine) than in the normal children (13.8 +/- 11.2 ng/g creatinine).	Creatinine	111-121	growth hormone 1	Homo sapiens	8-10
2403005-4	1990	Urinary GH levels were significantly lower in the eight children with complete GH deficiency (3.1 +/- 2.3 ng/g creatinine) than in the normal children (13.8 +/- 11.2 ng/g creatinine).	Creatinine	171-181	growth hormone 1	Homo sapiens	8-10
2403005-6	1990	However, when the cut-off point for defining GH insufficiency was set at 5 ng/g creatinine, 87.5% (21 out of 24) of the short children with low urinary GH levels were suitable subjects for GH treatment (i.e. had complete GH deficiency, partial GH deficiency or impaired GH secretion during sleep).	Creatinine	80-90	growth hormone 1	Homo sapiens	45-47
2183472-4	1990	The authors found significantly higher levels of serum creatinine in low-renin EH.	Creatinine	55-65	renin	Homo sapiens	73-78
3899153-5	1985	The fraction AUCu/AUC was closely related to serum albumin and creatinine concentrations determined at the time of study (multilinear regression correlation coefficient r2 = 0.830, P less than 0.0001); elevated serum creatinine and low albumin concentrations were associated with a higher % free.	Creatinine	217-227	albumin	Homo sapiens	45-58
33765901-5	2021	VCAM-1 level correlated with proteinuria, serum creatinine, and anti-dsDNA antibodies, and inversely correlated with C3.	Creatinine	48-58	vascular cell adhesion molecule 1	Homo sapiens	0-6
33973994-6	2021	RESULTS: Urinary ACE activity was significantly higher in patients with SCD than in healthy children (median 0.01; range 0.00-0.07 vs median 0.00; range 0.00-0.01 mU/mL creatinine, p < 0.001.	Creatinine	169-179	angiotensin I converting enzyme	Homo sapiens	17-20
33820760-3	2021	Nrf2 overexpression was associated with increased blood glucose, glomerular filtration rate, urinary albumin-creatinine ratio, tubulointerstitial fibrosis and Sglt2 expression in Akita Nrf2-/-/Nrf2RPTC Tg mice compared to their Akita Nrf2-/- littermates.	Creatinine	109-119	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
33820694-12	2022	CONCLUSIONS: Medical director"s practice of recommending an increase in DPI for HD patients with low albumin and high phosphate levels was associated with higher serum creatinine levels and potentially lower all-cause mortality.	Creatinine	168-178	albumin	Homo sapiens	101-108
33034916-5	2021	Urinary NGF and BDNF were normalized to creatinine (NGF/Cr, BDNF/Cr).	Creatinine	40-50	nerve growth factor	Homo sapiens	52-55
30445029-2	2019	Commonly used GFR estimation (eGFR) equations are based on serum creatinine (Cr) concentrations and display suboptimal precision and accuracy.	Creatinine	65-75	epidermal growth factor receptor	Homo sapiens	30-34
30445029-2	2019	Commonly used GFR estimation (eGFR) equations are based on serum creatinine (Cr) concentrations and display suboptimal precision and accuracy.	Creatinine	77-79	epidermal growth factor receptor	Homo sapiens	30-34
27698766-11	2016	The mean systolic blood pressure, urinary protein and creatinine in ApoE-/- group were significantly higher than ApoE+/- group and WT group (P&lt;0.05).	Creatinine	54-64	apolipoprotein E	Mus musculus	68-72
24728489-6	2015	U-AGT levels were not different between the daytime and nighttime in individuals without CKD, but were significantly higher in the daytime in CKD patients (log U-AGT/creatinine: daytime, 2.39 +- 0.99; nighttime, 2.24 +- 1.06; p = 0.001).	Creatinine	166-176	angiotensinogen	Homo sapiens	2-5
24907068-0	2015	Serum albumin, but not glycated albumin was a potent factor affecting the performance of GFR equation based on serum creatinine.	Creatinine	117-127	albumin	Homo sapiens	6-13
24792728-6	2015	However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared with that in full-term neonates (P = 0.0011).	Creatinine	40-50	angiotensinogen	Homo sapiens	21-36
24907068-2	2015	reported that high HbA1C or high glycated albumin (GA) level is a major factor in overestimation of GFR by Japanese GFR equation based on serum creatinine (Eq-cr).	Creatinine	144-154	albumin	Homo sapiens	42-49
24817138-8	2015	Renal ischemia increased phosphorylation of ERK 1/2 and NF-kappaB proteins as early as at 6 h. There was a significant increase in AGT and Ang II levels at 24 and 48 h. Prior saline loading prevented the increase in serum creatinine at 48 h (5.36 +- 1.26 vs. 3.38 +- 1.74 mg/dL, p &lt; 0.05), and suppressed the increases in renal (P)RR, AGT and Ang II contents.	Creatinine	222-232	angiotensinogen	Rattus norvegicus	131-134
24033747-7	2013	On univariate analysis, peak AST correlated with peak creatinine (P &lt; 0.001) and peak change in creatinine from baseline (P &lt; 0.001).	Creatinine	54-64	solute carrier family 17 member 5	Homo sapiens	29-32
24033747-7	2013	On univariate analysis, peak AST correlated with peak creatinine (P &lt; 0.001) and peak change in creatinine from baseline (P &lt; 0.001).	Creatinine	99-109	solute carrier family 17 member 5	Homo sapiens	29-32
24102663-7	2013	The median serum creatinine in pregnant women (46 micromol/L) was significantly lower and the median creatinine clearance (163 ml/min/1.73 m(2) ) was significantly higher than other groups (P &lt; 0.001 and P = 0.004, respectively).	Creatinine	101-111	CD59 molecule (CD59 blood group)	Homo sapiens	130-135
34146618-6	2022	OUTCOMES: Incident CKD defined as a recorded diagnosis of kidney replacement therapy (KRT), a recorded diagnosis of CKD, or by an estimated glomerular filtration rate <60 ml/min/1.73 m2 for >=90 days, or a urinary albumin-creatinine ratio >3 mg/mmol for >=90 days.	Creatinine	222-232	albumin	Homo sapiens	214-221
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	80-90	urate oxidase	Mus musculus	14-17
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	92-94	urate oxidase	Mus musculus	14-17
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	165-167	urate oxidase	Mus musculus	14-17
34583361-6	2022	Correction of SNa (from 127 +- 2.3 mEq/L to 139 +- 2.8 mEq/L) for >3 months, in the 12 patients (mean age 58 +- 18), was associated with an increase in 24-h creatinine excretion (from 986 +- 239 to 1,238 +- 220 mg; p < 0.02) and in patients treated with a vaptan (n = 5) solute excretion increased from 656 +- 207 mmol/24 h to 960 +- 193 mmol/24 h (p < 0.02).	Creatinine	157-167	snail family transcriptional repressor 1	Homo sapiens	14-17
34645988-0	2022	Urinary albumin-to-creatinine ratio and the risk of first stroke in Chinese hypertensive patients treated with angiotensin-converting enzyme inhibitors.	Creatinine	19-29	angiotensin I converting enzyme	Homo sapiens	111-140
34964416-7	2022	RESULTS: The application of CCl4 led to tubular necrosis, inflammation, vascular congestion, and increased Serum BUN and creatinine values.	Creatinine	121-131	C-C motif chemokine ligand 4	Rattus norvegicus	28-32
34936716-4	2022	Our data showed that increased expression of NDUFV1 improves kidney function as evidenced by the decreases in blood urea nitrogen and serum creatinine in UUO mice.	Creatinine	140-150	NADH:ubiquinone oxidoreductase core subunit V1	Mus musculus	45-51
34960089-10	2021	Multiple regression analysis, which included serum creatinine, albumin, and log CRP, simultaneously, in addition to sex, age, diabetic kidney disease or not, log HD duration, body mass index, systolic blood pressure, and Kt/V, as independent variables, revealed an independent and significant positive association of serum creatinine, but not serum albumin or CRP, with the serum FT3/FT4 ratio.	Creatinine	323-333	C-reactive protein	Homo sapiens	80-83
34960089-12	2021	The lack of association of the serum FT3/FT4 ratio with serum albumin and CRP suggested the presence of a creatinine-specific mechanism to associate with serum FT3/FT4 ratio.	Creatinine	106-116	C-reactive protein	Homo sapiens	74-77
1378179-6	1992	The microsuspension assay on XAD-2 or, even better, on C18 urine extracts was very sensitive in detecting up to 5 micrograms/g of creatinine of 1-OH PYR.	Creatinine	130-140	Bardet-Biedl syndrome 9	Homo sapiens	55-58
34956220-9	2021	Levels of serum pig IL-6, TNF-alpha, IL-1beta were also significantly increased on day 1 and at euthanasia, and serum pig IL-6 and IL-1beta correlated with serum creatinine and SAA.	Creatinine	162-172	interleukin-6	Sus scrofa	122-126
34948109-5	2021	After orthotopic delivery of PD-L1 gene into the kidneys, cisplatin-exposed mice displayed lower levels of both serum urea nitrogen and creatinine upon PD-L1 expression.	Creatinine	136-146	CD274 antigen	Mus musculus	29-34
34948109-5	2021	After orthotopic delivery of PD-L1 gene into the kidneys, cisplatin-exposed mice displayed lower levels of both serum urea nitrogen and creatinine upon PD-L1 expression.	Creatinine	136-146	CD274 antigen	Mus musculus	152-157
34956220-9	2021	Levels of serum pig IL-6, TNF-alpha, IL-1beta were also significantly increased on day 1 and at euthanasia, and serum pig IL-6 and IL-1beta correlated with serum creatinine and SAA.	Creatinine	162-172	interleukin 1 alpha	Sus scrofa	131-139
34943527-2	2021	Existing eGFR equations, usually based on serum levels of creatinine and/or cystatin C, are not uniformly accurate across patient populations.	Creatinine	58-68	epidermal growth factor receptor	Homo sapiens	9-13
34176389-6	2021	RESULTS: The TREM-1/TREM-2 ratio was decreased in CKD patients and correlated with serum creatinine, estimated glomerular filtration rate and cystatin c.	Creatinine	89-99	triggering receptor expressed on myeloid cells 2	Homo sapiens	20-26
34716603-8	2021	The main determinants of higher PENK concentrations were lower estimated glomerular filtration rate (eGFR), lower urinary creatinine excretion, and lower body mass index (all p < .001).	Creatinine	122-132	proenkephalin	Homo sapiens	32-36
34785062-6	2021	The top tertile of copeptin was, compared with reference tertile 1, significantly associated with both high CACS and high c-f PWV after adjustment for age, sex, hypertension, diabetes mellitus, HDL, triglycerides, BMI, smoking status, creatinine and high sensitive CRP with an odds ratio (OR) of 1.260 (95% confidence interval (CI): 1.022-1.555) for CACS and OR 1.389 (95% CI: 1.069-1.807) for PWV.	Creatinine	235-245	arginine vasopressin	Homo sapiens	19-27
34907424-1	2021	BACKGROUND: The ratio of creatinine to cystatin C (Cr:Cyc) has been proposed as a biomarker of sarcopenia, as greater Cr:Cyc is typically associated with greater muscle mass.	Creatinine	25-35	cytochrome c, somatic	Homo sapiens	54-57
34907424-1	2021	BACKGROUND: The ratio of creatinine to cystatin C (Cr:Cyc) has been proposed as a biomarker of sarcopenia, as greater Cr:Cyc is typically associated with greater muscle mass.	Creatinine	25-35	cytochrome c, somatic	Homo sapiens	121-124
34481845-7	2021	RESULTS: The final multivariable model was characterized by (1) additional variables of female sex and serum albumin, (2) interactions between bilirubin and sodium and between albumin and creatinine, and (3) an upper bound for creatinine at 3.0mg/dL.	Creatinine	188-198	albumin	Homo sapiens	176-183
34302440-10	2021	Changes in creatinine-to-cystatin C ratio showed inverse correlation with blood pressure, HbA1c, lipids, and C-reactive protein at the 4-year follow-up.	Creatinine	11-21	C-reactive protein	Homo sapiens	109-127
34583616-6	2021	The mean CIMT, right CIMT, left CIMT, blood urea, CRP, urinary albumin excretion creatinine and age show a negative linear relationship with fetuin-A.	Creatinine	81-91	alpha 2-HS glycoprotein	Homo sapiens	141-149
34261952-3	2021	METHODS: A total of 13 082 middle-aged and older individuals with SBP/DBP of less than 160/100 mmHg and urinary albumin-to-creatinine ratios (UACRs) of less than 300 mg/g, and who were free from ASCVD events, were followed to investigate the incidence of ASCVD.	Creatinine	123-133	albumin	Homo sapiens	112-119
34850142-3	2021	Our objective is to provide reference values for TmP/GFR from childhood to adulthood, using the gold-standard of GFR assessment and IDMS-standardized creatinine values.	Creatinine	150-160	epithelial membrane protein 1	Homo sapiens	49-52
33896334-8	2021	In addition, the expression of HDAC6 positively correlated with Masson trichrome positive area, serum urea, serum creatinine, beta2 macroglobulin, and cystatin C, while negatively correlated with eGFR and acetyl histone H3.	Creatinine	114-124	histone deacetylase 6	Homo sapiens	31-36
34332740-8	2021	In vivo, compared with untreated septic animals, MitoTEMPO reduced systemic IL-1beta (P=0.01), reduced renal oxidative stress as determined by urine isoprostane levels (P=0.04), and ameliorated renal dysfunction (reduced serum urea (P<0.001) and creatinine (P=0.05).	Creatinine	246-256	interleukin 1 alpha	Rattus norvegicus	76-84
34775475-0	2021	Urinary C-peptide and urinary C-peptide creatinine ratio as markers for insulin resistance in obese children and adolescents.	Creatinine	40-50	insulin	Homo sapiens	72-79
34643861-3	2022	The purpose of this study is to assess the association between urinary arsenic and metals and a higher albumin to creatinine ratio (ACR) among adults in the general US population.	Creatinine	114-124	albumin	Homo sapiens	103-110
34635505-6	2022	Pharmacological FLT3-ITD inhibition reduces intracellular creatinine levels through transcriptional down-regulation of genes in the de novo creatine biosynthesis pathway.	Creatinine	58-68	fms related receptor tyrosine kinase 3	Homo sapiens	16-20
34568976-4	2021	Compared to control mice, conditional disruption of tlr4 from myeloid cells, largely macrophages (> 85%), suppressed glomerular crescent formation and attenuated progressive renal injury by lowering serum creatinine and 24-h urine protein excretion while improving creatinine clearance.	Creatinine	205-215	toll-like receptor 4	Mus musculus	52-56
34568976-4	2021	Compared to control mice, conditional disruption of tlr4 from myeloid cells, largely macrophages (> 85%), suppressed glomerular crescent formation and attenuated progressive renal injury by lowering serum creatinine and 24-h urine protein excretion while improving creatinine clearance.	Creatinine	265-275	toll-like receptor 4	Mus musculus	52-56
34463730-5	2021	Serum albumin was added as covariate on the maximum binding capacity and endogenous creatinine clearance (CLCR) as covariate for renal function.	Creatinine	84-94	albumin	Homo sapiens	0-13
34798372-4	2022	RESULTS: Urinary angiotensinogen in preeclampsia patients (2.0 +- 1.1 ng/mg creatinine) was suppressed (*p < 0.05) compared to normal pregnant (2.7 +- 1.5 ng/mg creatinine).	Creatinine	76-86	angiotensinogen	Homo sapiens	17-32
34560070-5	2021	Notably, the 5-HT2AR antagonist sarpogrelate hydrochloride (SH) and the AADC inhibitor carbidopa (CDP) significantly attenuated cisplatin-induced increases in serum creatinine and blood urea nitrogen levels, renal ROS levels, oxidative stress (SOD activity and MDA), proinflammatory cytokine levels (NF-kappaB, TNF-alpha and IL-1beta), proapoptotic factor levels (Bax, Bcl-2, C-caspase 3 and C-caspase 9) and the phosphorylation of p38 and STAT3, as well as renal lesions and apoptosis.	Creatinine	165-175	5-hydroxytryptamine receptor 2A	Homo sapiens	13-20
34171450-12	2021	TNF-alpha demonstrated positive association with creatinine (r = 0.4,p = 0.006), BUN (r = 0.63,p = 0.003), sodium (r = 0.44, p = 0.04), potassium (r = 0.41, p = 0.04), and was negatively associated with RVFAC (r = -0.38,p = 0.03) and 6MWT distance (r = -0.54, p = 0.004).	Creatinine	49-59	tumor necrosis factor	Homo sapiens	0-9
34555645-8	2021	Positive correlation between creatinine with IFN-gamma, CCL-2/MCP-1, and CXCL-10/IP-10, and negative correlation with IL-10 was identified in patients with Kt/V < 1.2 (P < 0.05).	Creatinine	29-39	interferon gamma	Homo sapiens	45-54
34499310-0	2021	Comparison of urine albumin creatinine ratio with the pediatric index of mortality 2 score for prediction of pediatric intensive care unit outcomes.	Creatinine	28-38	albumin	Homo sapiens	20-27
34499310-2	2021	AIM: We compared the urine albumin creatinine ratio (ACR) with the established PICU score, pediatric index of mortality 2 (PIM 2) for predicting PICU outcomes.	Creatinine	35-45	albumin	Homo sapiens	27-34
34698914-6	2022	Gal-9 deficiency did not affect the LPS-induced increase in plasma tumor necrosis factor-alpha levels at 1 h or vascular permeability at 6 h. Lower urine volume and reduced creatinine clearance were observed in Gal-9-KO mice compared with wild-type mice after LPS administration.	Creatinine	173-183	lectin, galactose binding, soluble 9	Mus musculus	211-216
34815797-6	2021	T-cell-specific BPI transgenic (Lck-BPI Tg) mice showed multi-tissue inflammation with early induction of serum IL-1beta levels, as well as serum triglyceride and creatinine levels.	Creatinine	163-173	bactericidal permeablility increasing protein	Mus musculus	16-19
34686554-11	2021	By multivariable regression, on average, liver cirrhosis was associated with a reduced potassium lowering effect of 0.42 mmol/L (95% CI 0.22 to 0.63 mmol/L, p<0.001) from insulin-glucose treatment, after adjusting for age, serum creatinine, cancer, pretreatment potassium level, beta-blocker use and cotreatments (sodium polystyrene sulfonate, salbutamol, sodium bicarbonate).	Creatinine	229-239	insulin	Homo sapiens	171-178
34566512-6	2021	Case Report: A 56-year-old male with a long-standing history of CD treated with a tumor necrosis factor-alpha inhibitor presented with an acute elevation of creatinine in association with clinical and laboratory markers of nephrotic syndrome.	Creatinine	157-167	tumor necrosis factor	Homo sapiens	82-109
34508738-0	2021	Urine Albumin-Creatinine Ratio Is Associated with Prognosis in Patients with Diabetic Foot Osteomyelitis.	Creatinine	14-24	albumin	Homo sapiens	6-13
34508738-3	2021	Based on urine albumin-creatinine ratio (UACR), the patients were divided into three groups: normoalbuminuria group, microalbuminuria group and macroalbuminuria group.	Creatinine	23-33	albumin	Homo sapiens	15-22
34526412-10	2021	Urinary L-FABP was significantly correlated with serum creatinine (r=0.4674, P<0.01), urea nitrogen (r=0.4907, P<0.01), urine specific gravity (r=-0.5100, P<0.01), and urine protein/creatinine ratio (r=0.7216, P<0.01), but not with serum ALT.	Creatinine	55-65	fatty acid binding protein 1	Homo sapiens	8-14
34526412-10	2021	Urinary L-FABP was significantly correlated with serum creatinine (r=0.4674, P<0.01), urea nitrogen (r=0.4907, P<0.01), urine specific gravity (r=-0.5100, P<0.01), and urine protein/creatinine ratio (r=0.7216, P<0.01), but not with serum ALT.	Creatinine	182-192	fatty acid binding protein 1	Homo sapiens	8-14
34402675-4	2021	Clinically, GFR is estimated (eGFR) from serum creatinine or cystatin C levels.	Creatinine	47-57	epidermal growth factor receptor	Homo sapiens	30-34
34530560-5	2021	Exclusion criteria: (1) genetic testing revealed a D842V mutation in exon 18 of the PDGFRA gene; (2) alanine aminotransferase and/or aspartate aminotransferase > 2.5 times the normal upper limit; (3) serum total bilirubin >1.5 times of normal upper limit; (4) neutrophil count < 1.5x10(9)/L, or platelet count < 75x10(9)/L, or hemoglobin < 60 g/L; (5) creatinine > normal upper limit; (6) patients had serious cardiovascular and cerebrovascular diseases within 12 months before enrollment; (7) female patients were pregnant or lactating; (8) patients suffered from other serious acute and chronic physical or mental problems, and were not suitable for participating in this study judged by researchers.	Creatinine	352-362	platelet derived growth factor receptor alpha	Homo sapiens	84-90
34630276-5	2021	Results: Creatinine-based eGFR was 242 (+-80) and Cystatin C-based eGFR was 110 (+-23) mL/min/1.73 m2.	Creatinine	9-19	epidermal growth factor receptor	Homo sapiens	26-30
34630276-6	2021	Cystatin C-based eGFR was associated with age (beta -0.63 p < 0.0001) and galectin-3 levels (beta -0.43 p < 0.01), while creatinine-based eGFR was not (beta -0.22 p = 0.20; beta -0.28 p = 0.10).	Creatinine	121-131	epidermal growth factor receptor	Homo sapiens	138-142
34630276-7	2021	Sensitivity analyses in Duchenne and Becker patients revealed the same results: Cystatin C-based eGFR was associated with age (beta -0.61 p < 0.01) and galectin-3 levels (beta -0.43 p = 0.05), while creatinine-based eGFR was not (beta -0.32 p = 0.13; beta -0.34 p = 0.14).	Creatinine	199-209	epidermal growth factor receptor	Homo sapiens	216-220
34498313-8	2021	Urinary VEGFA was higher in male patients accompanied with higher serum creatinine, larger proportion of hypertension and recurrent hematuria than in female patients.	Creatinine	72-82	vascular endothelial growth factor A	Homo sapiens	8-13
34402675-6	2021	The creatinine-based equations calculate higher eGFR values (suggesting better kidney function) for black individuals.	Creatinine	4-14	epidermal growth factor receptor	Homo sapiens	48-52
34402675-7	2021	This upward adjustment for all black individuals is embedded in eGFR calculations on the belief of higher serum creatinine concentrations among black individuals than among white individuals.	Creatinine	112-122	epidermal growth factor receptor	Homo sapiens	64-68
34454731-15	2021	CONCLUSIONS: Living kidney donors practicing a day fast showed a different pattern regarding the change in creatinine levels.	Creatinine	107-117	Fas activated serine/threonine kinase	Homo sapiens	51-55
34487756-0	2021	Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus.	Creatinine	55-65	albumin	Homo sapiens	47-54
34487756-1	2021	AIM: To detect the expression levels of fasting serum fructose and ketohexokinase (KHK) in patients with type 2 diabetes mellitus (T2DM) at different stages of urinary albumin creatinine ratios (UACR) and serum uric acid (sUA).	Creatinine	176-186	albumin	Homo sapiens	168-175
34463135-6	2021	High plasma CX3CL1 was negatively correlated with platelet count (r = -0.5844, p < 0.0001) and positively correlated with blood urea nitrogen (r = 0.3668, p = 0.0039), creatinine (r = 0.42, p = 0.0008), and white blood cells (r = 0.2646, p = 0.0411).	Creatinine	168-178	C-X3-C motif chemokine ligand 1	Homo sapiens	12-18
34358031-6	2021	One of these IgA-dominant COVID-19 patients, concurrently with IgA nephropathy (IgAN), presented with elevated serum creatinine and worse proteinuria during the infection, which continued until seven months post-infection.	Creatinine	117-127	CD79a molecule	Homo sapiens	13-16
34507663-5	2021	Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine.	Creatinine	100-110	membrane metalloendopeptidase	Homo sapiens	6-9
34353366-10	2021	RESULTS: Plasma creatinine, blood urea nitrogen, and cystatin C were decrease by MSCp infusion as well as kidney injury molecule (KIM)-1 on histological kidney sections.	Creatinine	16-26	musculin	Rattus norvegicus	81-85
34532431-5	2021	Results: At baseline, the maximum creatine kinase-MB (CK-MB), plasma glucose, hemoglobin A1c, high-sensitivity C-reactive protein (CRP), and creatinine levels were higher, while the left ventricular ejection fraction (LVEF) was lower, in the insulin therapy group than in the OHA group.	Creatinine	141-151	insulin	Homo sapiens	242-249
34278443-3	2021	The levels of blood urea nitrogen (BUN) and serum creatinine (SCR) were increased by Ang II in the rats, and these were reversed by sinigrin in a dose-dependent manner.	Creatinine	50-60	angiotensinogen	Rattus norvegicus	85-91
34296783-12	2021	Transforming growth factor-beta and connective tissue growth factor were both positively correlated with homocysteine and creatinine.	Creatinine	122-132	tumor necrosis factor	Homo sapiens	0-31
34092512-0	2021	Role of the urinary N-acetyl-beta-D-glucosaminidase/creatinine (NAG/Cr) ratio in discriminating between true and false pyuria in sterile urine bag specimens.	Creatinine	52-62	N-acetyl-alpha-glucosaminidase	Homo sapiens	64-67
34238104-6	2021	RESULTS: LPS-induced AKI mice injected with the miR-494 antagomir showed reduced blood urea nitrogen (BUN) and serum creatinine (Cr) with improved kidney histopathology.	Creatinine	117-127	microRNA 494	Mus musculus	48-55
34238104-6	2021	RESULTS: LPS-induced AKI mice injected with the miR-494 antagomir showed reduced blood urea nitrogen (BUN) and serum creatinine (Cr) with improved kidney histopathology.	Creatinine	129-131	microRNA 494	Mus musculus	48-55
34471466-11	2021	Treatment of mice with PSF-SOD1 inhibited CP-induced serum creatinine, blood urea nitrogen elevation, and JNK/p38 MAPK activation.	Creatinine	59-69	interleukin 3	Mus musculus	23-26
34471466-11	2021	Treatment of mice with PSF-SOD1 inhibited CP-induced serum creatinine, blood urea nitrogen elevation, and JNK/p38 MAPK activation.	Creatinine	59-69	superoxide dismutase 1, soluble	Mus musculus	27-31
34414940-6	2021	Amounts of circulating GRP78 correlated directly with serum fasting c-peptide, cystatin-c (Cys-c), creatinine (Cr), blood urea nitrogen (BUN), and uric acid, and inversely with glomerular filtration rates.	Creatinine	99-109	heat shock protein family A (Hsp70) member 5	Homo sapiens	23-28
34414940-6	2021	Amounts of circulating GRP78 correlated directly with serum fasting c-peptide, cystatin-c (Cys-c), creatinine (Cr), blood urea nitrogen (BUN), and uric acid, and inversely with glomerular filtration rates.	Creatinine	111-113	heat shock protein family A (Hsp70) member 5	Homo sapiens	23-28
34414940-7	2021	Circulating CHOP level was positively correlated with age, Cr, BUN, Cys-c, and urinary microalbumin/creatinine (UmALB/Cr).	Creatinine	59-61	DNA damage inducible transcript 3	Homo sapiens	12-16
34414940-7	2021	Circulating CHOP level was positively correlated with age, Cr, BUN, Cys-c, and urinary microalbumin/creatinine (UmALB/Cr).	Creatinine	100-110	DNA damage inducible transcript 3	Homo sapiens	12-16
34414940-7	2021	Circulating CHOP level was positively correlated with age, Cr, BUN, Cys-c, and urinary microalbumin/creatinine (UmALB/Cr).	Creatinine	118-120	DNA damage inducible transcript 3	Homo sapiens	12-16
34414940-8	2021	Circulating GRP78 was predicted independently by Cr, BUN, serum uric acid, estimated glomerular filtration rate, and Cys-c, while CHOP depended on age, Cr, BUN, estimated glomerular filtration rate, UmALB/Cr, and Cys-c.	Creatinine	49-51	heat shock protein family A (Hsp70) member 5	Homo sapiens	12-17
34414940-8	2021	Circulating GRP78 was predicted independently by Cr, BUN, serum uric acid, estimated glomerular filtration rate, and Cys-c, while CHOP depended on age, Cr, BUN, estimated glomerular filtration rate, UmALB/Cr, and Cys-c.	Creatinine	152-154	heat shock protein family A (Hsp70) member 5	Homo sapiens	12-17
34414940-8	2021	Circulating GRP78 was predicted independently by Cr, BUN, serum uric acid, estimated glomerular filtration rate, and Cys-c, while CHOP depended on age, Cr, BUN, estimated glomerular filtration rate, UmALB/Cr, and Cys-c.	Creatinine	205-207	heat shock protein family A (Hsp70) member 5	Homo sapiens	12-17
34407760-9	2021	rAAV9-miR-29b delivery significantly reversed renal injury as indicated by decreased serum creatinine and injury related gene expression in AngII-infused mice.	Creatinine	91-101	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	140-145
34294186-9	2022	Angiotensin-converting enzyme inhibitors were used by 48% of patients and their use was associated with creatinine clearance <90 ml/min (p = 0.007), as was Fontan completion at an older age (p = 0.007).	Creatinine	104-114	angiotensin I converting enzyme	Homo sapiens	0-29
34246297-9	2021	Five of those miRNAs (hsa-miR-126-3p, hsa-miR-142-3p, hsa-miR-146a-5p, hsa-miR-155-5p, and hsa-miR-222-3p) also had a positive correlation with serum creatinine and therefore a negative correlation with eGFR.	Creatinine	150-160	epidermal growth factor receptor	Homo sapiens	203-207
34584354-0	2021	Spot Urine Albumin Creatinine Ratio can be a Predictor of Cognitive Function in Type 2 Diabetes Mellitus.	Creatinine	19-29	albumin	Homo sapiens	11-18
34171186-11	2021	In addition, there were significant higher percentage of ATN, higher levels of plasma urea and creatinine, and higher levels of cathepsin B and cathepsin D, in kidneys of cisplatin-treated GAL-3 KO mice than cisplatin-treated GAL-3 wild mice.	Creatinine	95-105	lectin, galactose binding, soluble 3	Mus musculus	189-194
34088317-9	2021	The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI).	Creatinine	63-73	interleukin 6	Homo sapiens	14-18
34118794-8	2021	Those with high levels of U-BPA (U-BPA >=2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine).	Creatinine	51-61	insulin	Homo sapiens	89-96
34088317-9	2021	The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI).	Creatinine	63-73	tumor necrosis factor	Homo sapiens	23-32
31895114-11	2021	Significant correlations were observed between sclerostin levels and serum creatinine, proteinuria, consumed C3 and C4 complement, and corrected Ca.	Creatinine	75-85	sclerostin	Homo sapiens	47-57
34472785-8	2021	The glomerular filtration rate showed significant negative correlation with the levels of podocin excreted in urine whereas urinary podocin positively correlated with the fasting blood sugar, post prandial sugar, glycosylated haemoglobin, triglyceride levels and the duration of diabetes along with systolic and diastolic blood pressure, body mass index, microalbumin and urine albumin-creatinine ratio.	Creatinine	386-396	NPHS2 stomatin family member, podocin	Homo sapiens	132-139
34093028-0	2021	Lipid Accumulation Product is Associated with Urinary Albumin-creatinine Ratio in Chinese Prediabitic Population: A Report from the REACTION Study.	Creatinine	62-72	albumin	Homo sapiens	54-61
34093028-5	2021	Elevated albuminuria was defined by urinary albumin-creatinine ratio (uACR) >=30 mg/g.	Creatinine	52-62	albumin	Homo sapiens	44-51
34150128-8	2021	The relative expression level of miRNA-192-5p in the serum of patients with high beta2-MG and creatinine levels was markedly reduced compared to that in patients with low beta2-MG levels (P < 0.05); the relative expression level of miRNA-192-5p in the serum of patients with low hemoglobin and albumin levels was markedly reduced compared to that in patients with normal hemoglobin and albumin (P < 0.05); and there was significantly negative correlation between the relative expression level of miRNA-192-5p in the serum of MM patients and IgG and IgA levels, respectively (P < 0.05).	Creatinine	94-104	microRNA 192	Homo sapiens	33-42
34136707-0	2021	Arginine Vasopressin as an Important Mediator of Fluctuations in the Serum Creatinine Concentration Under Decongestion Treatment in Heart Failure Patients.	Creatinine	75-85	arginine vasopressin	Homo sapiens	9-20
34316721-9	2021	Urinary cAMP normalized to creatinine positively correlated with eGFR.	Creatinine	27-37	epidermal growth factor receptor	Homo sapiens	65-69
34150128-8	2021	The relative expression level of miRNA-192-5p in the serum of patients with high beta2-MG and creatinine levels was markedly reduced compared to that in patients with low beta2-MG levels (P < 0.05); the relative expression level of miRNA-192-5p in the serum of patients with low hemoglobin and albumin levels was markedly reduced compared to that in patients with normal hemoglobin and albumin (P < 0.05); and there was significantly negative correlation between the relative expression level of miRNA-192-5p in the serum of MM patients and IgG and IgA levels, respectively (P < 0.05).	Creatinine	94-104	microRNA 192	Homo sapiens	232-241
34150128-8	2021	The relative expression level of miRNA-192-5p in the serum of patients with high beta2-MG and creatinine levels was markedly reduced compared to that in patients with low beta2-MG levels (P < 0.05); the relative expression level of miRNA-192-5p in the serum of patients with low hemoglobin and albumin levels was markedly reduced compared to that in patients with normal hemoglobin and albumin (P < 0.05); and there was significantly negative correlation between the relative expression level of miRNA-192-5p in the serum of MM patients and IgG and IgA levels, respectively (P < 0.05).	Creatinine	94-104	microRNA 192	Homo sapiens	496-505
34801997-10	2021	(2) A negative correlation between the eGFR and MMP-2, MMP-3, and TIMP-2 and a positive correlation between creatinine and MMP-3 levels indicate the role of MMPs and TIMP-2 in renal dysfunction.	Creatinine	108-118	matrix metallopeptidase 3	Homo sapiens	123-128
34496361-5	2021	RESULTS: TGF-beta1 expression correlated positively with segmental glomerulosclerosis (p= 0.025) and creatinine level at diagnosis (p = 0.002), while pSmad3 expression with interstitial inflammation (p = 0.024).	Creatinine	101-111	transforming growth factor beta 1	Homo sapiens	9-18
35447340-5	2022	db/db mice at 12-month-old without FGF1DeltaHBS treatment exhibited high blood glucose level and elevated urine albumin-to-creatinine ratio.	Creatinine	123-133	fibroblast growth factor 1	Mus musculus	35-39
35000065-7	2022	In ESRD patients, we found a trend of negative correlation between the increased FiCD values of bilateral middle frontal gyrus and serum creatinine, urea, parathyroid hormone(PTH) levels and dialysis duration.	Creatinine	137-147	FIC domain protein adenylyltransferase	Homo sapiens	81-85
35113370-5	2022	The results showed that the odds ratios of ALT and AST in the highest quartiles of urinary Cd were 1.40 (95% confidence interval (CI), 1.07-1.82) and 1.64 (95% CI, 1.10-2.44), respectively, compared with the lowest quartiles, which were similar to using urinary creatinine as the covariate.	Creatinine	262-272	solute carrier family 17 member 5	Homo sapiens	51-54
34242326-8	2021	Regarding laboratory data, adiponectin level was associated with creatinine, and chemerin level was associated with creatinine, albumin, and erythrocyte sedimentation rate (ESR).	Creatinine	65-75	adiponectin, C1Q and collagen domain containing	Homo sapiens	27-38
35359021-3	2022	The serum levels of creatinine (SCr), blood urea nitrogen (BUN), IL-6, and TNF-alpha were measured by ELISA test, as well as the levels of the kidney tissue malondialdehyde (MDA), and glutathione (GSH) were also estimated spectrophotometrically.	Creatinine	20-30	scruffy	Mus musculus	32-35
35634998-4	2022	Spearman correlation test was used to analyze the correlation of the IL-6 with C-reactive protein(CRP), erythrocyte sedimentation rate (ESR), creatinine, and cystatin C.	Creatinine	142-152	interleukin 6	Homo sapiens	69-73
35508416-0	2022	Estimating urine albumin to creatinine ratio from protein to creatinine ratio using same day measurement: validation of equations.	Creatinine	61-71	albumin	Homo sapiens	17-24
35634998-7	2022	Correlation analysis showed that IL-6 in the group with disease course >= 5 years had a positive correlation with ESR (Rs=0.438, P=0.022) and CRP (Rs=0.825, P<0.001), whereas it was negatively correlated with creatinine (Rs=-0.481, P=0.011).	Creatinine	209-219	interleukin 6	Homo sapiens	33-37
35610700-7	2022	Apelin levels showed significantly negative correlation with diabetes duration, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C, creatinine and high sensitivity C-reactive protein (hs-CRP), and positive correlation with high-density lipoprotein cholesterol (HDL-C) and brain-derived neurotrophic factor (BDNF).	Creatinine	167-177	apelin	Homo sapiens	0-6
35610700-8	2022	Multivariable logistic regression analysis indicated that serum apelin (OR = 0.304, 95%CI: 0.104-0.886, P = 0.029), as well as education levels, diabetes duration, cardiovascular disease, serum HbA1c, HDL-C, creatinine, and BDNF, were independent risk factors of MCI in patients with T2DM.	Creatinine	208-218	apelin	Homo sapiens	64-70
35579574-7	2022	Moreover, in cisplatin- or ischemia/reperfusion (I/R) induced AKI mouse model, detection of creatinine and urea nitrogen in blood showed that Cpd-2 improved kidney function.	Creatinine	92-102	Ca2+-dependent activator protein for secretion 2	Mus musculus	142-147
35631220-6	2022	Moreover, oral administration of Lactobacillus plantarum NK151, Bifidobacterium longum NK173, and Bifidobacterium bifidum NK175, which inhibited LPS-induced IL-6 expression in macrophages, alleviated cGm-induced depression-like behaviors, hippocampal NF-kappaB+Iba1+ cell numbers and IL-1beta and IL-6 expression, blood LPS, IL-6, and creatinine levels, and colonic NF-kappaB+CD11c+ number and IL-1beta and IL-6 expression in mice.	Creatinine	335-345	interleukin 6	Mus musculus	157-161
35549355-6	2022	Urinary albumin excretion was calculated from the albumin-creatinine ratio in fresh spot urine (urinary albumin-creatinine ratio (UACR)).	Creatinine	58-68	albumin	Homo sapiens	8-15
35549355-6	2022	Urinary albumin excretion was calculated from the albumin-creatinine ratio in fresh spot urine (urinary albumin-creatinine ratio (UACR)).	Creatinine	112-122	albumin	Homo sapiens	8-15
35128589-10	2022	Anti-tubulin-alpha-1c detected significant direct correlation with the presence of posterior uveitis, panuveitis, and venous thrombosis as well as BVAS, C4, and protein/creatinine ratio.	Creatinine	169-179	tubulin alpha 1c	Homo sapiens	5-21
35522589-8	2022	The median (IQR) urinary podocalyxin levels were 0.81 (0.27, 3.68), 0.92 (0.44, 5.49) and 64.7 (30.5, 106.3) ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (p<0.0001).	Creatinine	115-125	podocalyxin like	Homo sapiens	25-36
35522589-9	2022	Patients with hematuria during labor had higher levels of urinary podocalyxin (128.6 (79.8, 169.6) ng/mg creatinine.	Creatinine	105-115	podocalyxin like	Homo sapiens	66-77
35369322-13	2022	FGF21 was positively correlated with NT-proBNP, BUN, AST, creatinine and cholesterol, and negatively correlated with ALB and HDL.	Creatinine	58-68	fibroblast growth factor 21	Homo sapiens	0-5
35393388-7	2022	ALB was positively correlated with total cholesterol (TC) (r=0.359, P<0.05), low-density lipoprotein cholesterol (LDL-C) (r=0.283, P<0.05), and serum apolipoprotein A1 (APOA1) (r=0.429, P<0.05) and was negatively correlated with serum creatinine (SCr) (r=0.129, P<0.05) in patients with AF.	Creatinine	235-245	albumin	Homo sapiens	0-3
35453583-10	2022	Using three combined biomarkers, serum CA125, urinary VDBP, and A1AT creatinine ratio, provided good detection power (AUC 0.913, p = 0.001, sensitivity 90.9%, specificity 76.5%).	Creatinine	69-79	serpin family A member 1	Homo sapiens	64-68
35197257-0	2022	Variations in Deceased Donor Terminal Creatinine Values Reported in the OPTN Data Registry.	Creatinine	38-48	optineurin	Homo sapiens	72-76
35581050-12	2022	Meanwhile, the meta-regression results of the random effect model showed that HbA1c (P = 0.021), BMI (P = 0.029), and creatinine levels (P = 0.003) had significant effects on the heterogeneity of the relationship between IDFU, and serum CRP levels.	Creatinine	118-128	C-reactive protein	Homo sapiens	237-240
35249274-12	2022	Insulin resistance and inflammation appeared to be key mediators accounting for the observed relationship between normalized creatinine-to-cystatin C ratio and risk of diabetes, with their mediating effect being 93.1% and 22.0%, respectively.	Creatinine	125-135	insulin	Homo sapiens	0-7
35072877-14	2022	Also, there was a negative correlation between the AChE level and each of SGPT, SGOT, ALP, globulin, blood urea, and serum creatinine for the exposed group reaching a statistically significant level with each of SGPT and SGOT (P < 0.05).	Creatinine	123-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
35373950-1	2022	OBJECTIVE: Bladder wall thickness (BWTh) measurements and Nerve Growth Factor (NGF) /creatinine (Cr) values, as noninvasive tools, were found to predict daytime voiding problems in children with overactive bladder (OAB).	Creatinine	97-99	nerve growth factor	Homo sapiens	58-77
35373950-14	2022	In receiver operating characteristic analysis, bladder wall thickness was found to have sensitivity of 85% and specificity of 84.2% (3,20 AUC ,913; 95 %) and NGF/Cr had sensitivity of 90% and specificity of 92.1% (1,595; AUC ,947; 95 %) in predicting treatment outcome in children with OAB.	Creatinine	162-164	nerve growth factor	Homo sapiens	158-161
35199942-10	2022	The NT-proANP/corin levels were positively correlated with LAD, creatinine, and urine protein, and negatively correlated with eGFR in HDP group (p < .05 each).	Creatinine	64-74	corin, serine peptidase	Homo sapiens	4-19
35199942-11	2022	Multiple regressions demonstrated that NT-proANP was an independent risk factor of LAD and urine protein, and corin was an independent risk factor of creatinine and eGFR in HDP group.	Creatinine	150-160	corin, serine peptidase	Homo sapiens	110-115
35277788-7	2022	However, negative correlations were found between IL-33 and urea and sodium concentrations and between Bcl-2 and HbA1c% and creatinine levels.	Creatinine	124-134	BCL2 apoptosis regulator	Homo sapiens	103-108
35626276-3	2022	We recently reported the clinical performance of a new eGFR equation (GFRNMR) based on the nuclear magnetic resonance (NMR) measurement of serum myo-inositol, valine, and creatinine, in addition to the immunoturbidometric quantification of serum cystatin C, age and sex.	Creatinine	171-181	epidermal growth factor receptor	Homo sapiens	55-59
35629898-7	2022	Regarding therapeutics, TNF inhibitors may increase the levels of tryptophan, valine, lysine, creatinine and alanine, whereas JAK/STAT inhibitors may modulate exclusively fatty acids.	Creatinine	94-104	tumor necrosis factor	Homo sapiens	24-27
35468098-5	2022	METHODS: We recruited 157 type 2 diabetes patients over 55 years old and investigated the prevalence of sarcopenia in diabetes patients and examined the association of ET-1 alterations with HbA1c, creatinine, or AMS/ht2.	Creatinine	197-207	endothelin 1	Homo sapiens	168-172
35467153-11	2022	For centres with no access to cystatin C, a creatinine-based equation, eGFR (mL/min/1.73 m2) = 89.674 (height(m)/Scr(mg/dL)/2.7)0.579 ( 1.007male) (height(m)/1.4)0.187, was derived, with P30 and P15 73.60% and 49.20%, respectively.	Creatinine	44-54	epidermal growth factor receptor	Homo sapiens	71-75
35625671-10	2022	The expression levels of TNFalpha, IL-2, IL-4, IL-6, IL-8, and IL-10 were higher in patients treated with continuous renal replacement therapy (CRRT) (p < 0.05), and the levels of the maximum plasma creatinine and TNFalpha Spearman"s rank-order correlation coefficient (rho = 0.51, p < 0.05) and IL-8 (rho = 0.44, p < 0.05) correlated.	Creatinine	199-209	tumor necrosis factor	Homo sapiens	25-33
35498429-11	2022	Univariate and multivariate logistic regression analysis determined that lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were independent risk factors for predicting POF in APIP.	Creatinine	117-127	POF1B actin binding protein	Homo sapiens	192-195
35498429-16	2022	Lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were the independent risk factors of POF in APIP.	Creatinine	44-54	POF1B actin binding protein	Homo sapiens	111-114
35496306-5	2022	The creatinine-adjusted concentrations of glutamic and succinic acids and succinylcarnitine significantly increased, whereas that of glycolic acid significantly decreased with advancing age.	Creatinine	4-14	renin binding protein	Homo sapiens	186-189
35422637-7	2022	Mean decreased change of eGFR calculated by serum creatinine proved the same conclusion.	Creatinine	50-60	epidermal growth factor receptor	Homo sapiens	25-29
35354439-8	2022	RESULTS: NSD2 was poorly expressed in the serum of patients with DN and was negatively correlated with the levels of fasting blood sugar (FBG), serum creatinine (SCr), serum cystatin C (S-Cys-C), the 24-h urine protein (24-h U-protein) and the urine cystatin C (U-Cys-C).	Creatinine	150-160	nuclear receptor binding SET domain protein 2	Homo sapiens	9-13
35368529-8	2022	These increasing of urea and creatinine levels caused consequently the turbulence of the oxidative stress as well as the rising of hs-CRP, IL-6, and TNF-alpha levels in the serum.	Creatinine	29-39	C-reactive protein	Rattus norvegicus	134-137
35368529-8	2022	These increasing of urea and creatinine levels caused consequently the turbulence of the oxidative stress as well as the rising of hs-CRP, IL-6, and TNF-alpha levels in the serum.	Creatinine	29-39	interleukin 6	Rattus norvegicus	139-143
35368529-8	2022	These increasing of urea and creatinine levels caused consequently the turbulence of the oxidative stress as well as the rising of hs-CRP, IL-6, and TNF-alpha levels in the serum.	Creatinine	29-39	tumor necrosis factor	Rattus norvegicus	149-158
35298547-2	2022	Some patients with IC experience a rise in Urinary N-acetyl-beta-D-Glucosaminidase (NAG)/ Creatinine (Cr) ratio, a marker of renal injury, following exercise.	Creatinine	102-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	84-87
35260678-8	2022	When cross-classified by the presence of proteinuria and serum creatinine level, the mean eGFR slopes significantly differed between the febuxostat and placebo groups (P = 0.040) in cross-classified subcohorts without proteinuria and with serum creatinine level >= median, but not in the cross-classified subcohorts with proteinuria and serum creatinine level < median.	Creatinine	63-73	epidermal growth factor receptor	Homo sapiens	90-94
35278147-5	2022	Overall, there was a significantly lower estimated glomerular filtration rate (eGFR) in IgA nephropathy patients with BMI in the overweight/obese range than in those with normal BMI (mean difference 6.01, 95% CI 2.78-9.24 ml/min/1.73 m2, P < 0.001), but no significant difference in serum creatinine or proteinuria levels.	Creatinine	289-299	CD79a molecule	Homo sapiens	88-91
35443444-17	2022	CONCLUSION: We found out that both serum creatinine and serum cystatin C were significantly increased across CKD groups but cystatin C is a better predictor of CKD than creatinine in stages with eGFR>=60 ml/min/1.73 m2 as serum cystatin C was found to be raised contrary to serum creatinine which was within normal limits, although in stages with eGFR<60 ml/min/1.73 m2 there was no significant difference between the two.	Creatinine	41-51	epidermal growth factor receptor	Homo sapiens	195-199
35443444-18	2022	We found out that normal serum creatinine levels during the stage of kidney disease with eGFR>=60 ml/min/1.73 m2 does not necessarily mean normal renal function.	Creatinine	31-41	epidermal growth factor receptor	Homo sapiens	89-93
35402074-3	2022	In the current study, we observed that the long non-coding RNA (lncRNA) MIAT was noticeably upregulated in the plasma and kidney tissues of patients with diabetic nephropathy, and this upregulation was accompanied by higher albumin/creatinine ratios and serum creatinine levels.	Creatinine	232-242	myocardial infarction associated transcript	Homo sapiens	72-76
35402074-3	2022	In the current study, we observed that the long non-coding RNA (lncRNA) MIAT was noticeably upregulated in the plasma and kidney tissues of patients with diabetic nephropathy, and this upregulation was accompanied by higher albumin/creatinine ratios and serum creatinine levels.	Creatinine	260-270	myocardial infarction associated transcript	Homo sapiens	72-76
35260678-8	2022	When cross-classified by the presence of proteinuria and serum creatinine level, the mean eGFR slopes significantly differed between the febuxostat and placebo groups (P = 0.040) in cross-classified subcohorts without proteinuria and with serum creatinine level >= median, but not in the cross-classified subcohorts with proteinuria and serum creatinine level < median.	Creatinine	245-255	epidermal growth factor receptor	Homo sapiens	90-94
35260678-8	2022	When cross-classified by the presence of proteinuria and serum creatinine level, the mean eGFR slopes significantly differed between the febuxostat and placebo groups (P = 0.040) in cross-classified subcohorts without proteinuria and with serum creatinine level >= median, but not in the cross-classified subcohorts with proteinuria and serum creatinine level < median.	Creatinine	343-353	epidermal growth factor receptor	Homo sapiens	90-94
35249010-7	2022	Patients having longer PBT had more AKI complicating the course of STEMI (7 % vs. 8 % vs. 13 %, p<0.001) and had significantly higher serum creatinine changes throughout hospitalization (0.08 mg/dl vs. 0.11 mg/dl vs.0.17 mg/dl p<0.001).	Creatinine	140-150	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-26
35295167-7	2022	(3) For IgA nephropathy patients with serum creatinine less than 1.50 mg/dl, the curative effect of glucocorticoid treatment was better than that of the control group (P < 0.01).	Creatinine	44-54	CD79a molecule	Homo sapiens	8-11
35247980-8	2022	Logistic regression analysis indicated that diabetes (OR2.908, 95%CI1.844 ~ 4.231), pulmonary infection(OR3.755, 95%CI2.831 ~ 4.987), albumin <= 24 g/L (OR1.923, 95%CI1.214 ~ 2.355), serum creatinine >= 90 mumol/L (OR2.517, 95%CI2.074 ~ 3.182), blood urea nitrogen >= 6.5 mmol/L (OR1.686, 95%CI1.208 ~ 2.123), uric acid >= 390 mumol/L (OR2.755, 95%CI2.131 ~ 3.371), renal tubular casts(OR1.796, 95%CI1.216 ~ 2.208) were the independently influencing factors of AKI in PNS patients (all P < 0.05).	Creatinine	189-199	albumin	Homo sapiens	134-141
35370932-4	2021	Non-invasive diabetic detection technology was used to detect AGEs in the upper arm skin of all participants, AGE accumulations were classified as <=P25, P25~P50, P50~P75, and >P75; HbA1c, insulin, C-peptide, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), creatinine, urea, and other indicators were measured at the same time.	Creatinine	298-308	renin binding protein	Homo sapiens	110-113
35244046-9	2022	Subgroup analyses revealed that pre-operative EPO treatment significantly reduced the incidence of CSA-AKI, intra-operative RBC transfusion, serum creatinine, and length of hospital and ICU stay.	Creatinine	147-157	erythropoietin	Homo sapiens	46-49
35308545-7	2022	Regression analysis revealed that albumin (OR: 0.0311; p = 0.023), CRP (OR: 3.234; p = 0.034) and FABP2 levels (OR:1.000, p = 0.040), CP score (OR: 2.504; p = 0.016), CP creatinine score (OR: 2.366; p = 0.008), end-stage liver disease model (MELD), Na (OR: 1.283; p = 0.033), portal vein thrombosis (OR: 0.075; p = 0.008), hepatocellular carcinoma (OR: 0.060; p = 0.003) and encephalopathy (OR: 0.179; p = 0.045) were significantly associated with 6-week mortality.	Creatinine	170-180	fatty acid binding protein 2	Homo sapiens	98-103
35309508-9	2022	Results: Urinary levels of angiotensinogen were significantly higher in the gestational diabetes (angiotensinogen/creatinine ratio median (25th, 75th): 0.11 (0.07, 0.18)) and preeclampsia (0.08 (0.06, 0.18)) groups than in those with healthy pregnancy (0.05(0.04, 0.06); 6-sulfatoxymelatonin levels were significantly lower in the gestational diabetes (ug/h: median (25th, 75th): 0.12(0.08, 0.17)) and preeclampsia (0.12 (0.09, 0.15)) groups than in those with healthy pregnancy (0.20 (0.15, 0.27).	Creatinine	114-124	angiotensinogen	Homo sapiens	27-42
35120907-11	2022	There were positive correlations between the levels of CXCL16 and serum creatinine, IL-6, CRP, and TNF-alpha and negative correlations with eGFR.	Creatinine	72-82	C-X-C motif chemokine ligand 16	Homo sapiens	55-61
35268356-6	2022	The concentration of vanin/creatinine correlates positively with the level of IgA and negatively with the serum level of C3 at the end of the observation.	Creatinine	27-37	CD79a molecule	Homo sapiens	78-81
35293346-7	2022	NLR positively correlated with C-reactive protein (CRP), complement 3(C3), C4, and serum creatinine (SCr) (CRP: r=0.337, p=0.007; C3: r=0.222, p=0.042; C4: r=0.230, p=0.035; SCr: r=0.408, p<0.0001) but negatively correlated with total serum IgG (r=-0.226, p=0.041).	Creatinine	89-99	C-reactive protein	Homo sapiens	107-110
35051728-9	2022	Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months).	Creatinine	67-77	tumor necrosis factor	Homo sapiens	49-52
35051728-9	2022	Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months).	Creatinine	67-77	interleukin 6	Homo sapiens	57-61
35220678-0	2022	Metabolic Score for Insulin Resistance, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin-to-creatinine ratio in Chinese adults: A cross-sectional REACTION study.	Creatinine	129-139	insulin	Homo sapiens	66-73
35189851-2	2022	METHODS: In a national cohort of 855,133 veterans with T2D seen at Veteran Affairs clinics between Jan 1, 2008 and December 31, 2010 with at least two serum creatinine measurements, we defined insulin use from pharmacy records and serious hypoglycemic events by ICD-9/10 codes from emergency room visits or hospitalizations that occurred until December 31, 2016.	Creatinine	157-167	insulin	Homo sapiens	193-200
35215419-12	2022	However, if creatinine blood levels increased within the PN group, lower overall survival was found (HR = 2.046, p = 0.007).	Creatinine	12-22	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	57-59
35138387-6	2022	RESULTS: At 20-weeks post-5/6Nx, L34-treated mice showed significantly lesser renal injuries, as evaluated by i) kidney fibrosis area (P < 0.01) with lower serum creatinine and proteinuria, ii) GDUT including trimethylamine-N-oxide (TMAO) (P = 0.02) and indoxyl sulfate (P < 0.01), and iii) endotoxin (P = 0.03) and serum TNF-alpha (P = 0.01), than 5/6Nx-controls.	Creatinine	162-172	lectin, galactose binding, soluble 3	Mus musculus	33-36
35204773-6	2022	In both groups there was a significant correlation between IGFBP7 and serum parameters of kidney function (creatinine concentration: population gr.	Creatinine	107-117	insulin like growth factor binding protein 7	Homo sapiens	59-65
35204773-13	2022	Multivariate regression analysis in joint both revealed that the IGFBP7 concentration is independently associated with urea, creatinine and TnT concentrations (R2 for the model 0.76).	Creatinine	125-135	insulin like growth factor binding protein 7	Homo sapiens	65-71
35094407-12	2022	CONCLUSIONS: For patients with renal dysfunction and mildly reduced eGFR (60<=GFR < 90 ml/min/1.73 m2 ), improved cardiac function after CABG surgery can reduce the serum creatinine level and reduce the risk for postoperative AKI.	Creatinine	171-181	epidermal growth factor receptor	Homo sapiens	68-72
35197735-5	2022	In renal samples of rats treated with CCl4, the antioxidant enzymes (POD, SOD, CAT), PH level, protein level, and glutathione contents were significantly (p < 0.05) declined whereas renal biochemicals (H2O2, TBARS, and nitrite), specific gravity, level of urea, urobilinogen, serum BUN and creatinine were markedly (p < 0.05) increased relative to control group.	Creatinine	290-300	C-C motif chemokine ligand 4	Rattus norvegicus	38-42
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	242-252	interleukin 6	Mus musculus	0-13
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	242-252	tumor necrosis factor	Mus musculus	25-52
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	242-252	tumor necrosis factor	Homo sapiens	54-63
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	254-256	interleukin 6	Mus musculus	0-13
35083252-9	2021	Arterial flow, pH, NGAL and L-FABP correlated with donor creatinine and eGFR.	Creatinine	57-67	fatty acid binding protein 1	Homo sapiens	28-34
35097010-9	2021	Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR).	Creatinine	254-264	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
35308655-9	2022	An inverse correlation was found between creatinine clearance and highly sensitive C-reactive protein (p 0.0174).	Creatinine	41-51	C-reactive protein	Homo sapiens	83-101
35283570-7	2022	Children with lower CD4 counts had significant higher mean Albumin Creatinine Ratio (ACR) and mean uNGAL; P = 0.03, P = 0.01.	Creatinine	67-77	CD4 molecule	Homo sapiens	20-23
34975301-8	2022	Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin.	Creatinine	97-107	fatty acid binding protein 3	Homo sapiens	22-27
35173546-5	2022	CD137-positive lymphatic vessels were involved in the development process of IgA nephropathy and positively correlated with serum creatinine, serum urea nitrogen, serum uric acid, and urinary 24 h total protein.	Creatinine	130-140	CD79a molecule	Homo sapiens	77-80
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	254-256	tumor necrosis factor	Mus musculus	25-52
35173832-4	2022	Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in mouse serum were detected by Enzyme-linked immunosorbent assay (ELISA); fibronectin (FN) and type I collagen (Col-I) in renal tissue were detected by Western blotting; serum creatinine (Cr) and blood urea nitrogen (BUN) were analyzed by kits.	Creatinine	254-256	tumor necrosis factor	Homo sapiens	54-63
35582189-3	2022	Methods: In a longitudinal cohort study of older persons without prior cardiovascular disease, we estimated the associations between baseline eGFR (in ml/min per 1.73 m2) and albuminuria, measured as urine albumin-creatinine ratio (UACR; in mg/mmol) and cognitive test scores, declines in cognitive test scores, and incident dementia using adjusted linear and linear mixed models.	Creatinine	214-224	epidermal growth factor receptor	Homo sapiens	142-146
35291613-7	2022	Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations.	Creatinine	108-118	interleukin 2	Homo sapiens	57-61
35291613-10	2022	The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy.	Creatinine	99-109	interleukin 2	Homo sapiens	28-32
35419273-9	2022	While there was a significant elevation of the aspartate amino transferase (AST) (n = 6, SMD; 0.76; 95%CI; (0.41, 1.11), p = 0.0001, I2 = 89%), alkaline phosphatase (ALP) (n = 5, SMD; 1.92; 95% CI; (0.02, 3.83), p = 0.05, I2 = 92%), and creatinine (n = 4, SMD = 1.56; 95% CI; (0.05, 3.07), p = 0.04, I2 = 90%) concentrations in comparison to the control.	Creatinine	237-247	solute carrier family 17 member 5	Homo sapiens	76-79
34843183-9	2022	Urine albumin/creatinine-ratios correlated positively with plasma IL-6 at baseline.	Creatinine	14-24	interleukin 6	Homo sapiens	66-70
2775040-7	1989	All patients experienced some impairment in renal function with mean creatinine clearance decreasing from 129 +/- 19 to 91 +/- 13 ml/min/1.73m2 (p less than 0.05).	Creatinine	69-79	CD59 molecule (CD59 blood group)	Homo sapiens	133-138
2684712-4	1989	The mean 24-h urinary GH in NIDDM subjects was 11.1 +/- 1.9 ng/g creatinine (Cr), which was not significantly different from that in nondiabetic control subjects (9.2 +/- 2.7 ng/g Cr).	Creatinine	65-75	growth hormone 1	Homo sapiens	22-24
2684712-4	1989	The mean 24-h urinary GH in NIDDM subjects was 11.1 +/- 1.9 ng/g creatinine (Cr), which was not significantly different from that in nondiabetic control subjects (9.2 +/- 2.7 ng/g Cr).	Creatinine	77-79	growth hormone 1	Homo sapiens	22-24
2530666-6	1989	In the six patients with functioning grafts, ANF declined in parallel with the fall in serum creatinine (658 +/- 35 to 210 +/- 34 mumol/L).	Creatinine	93-103	natriuretic peptide A	Homo sapiens	45-48
2530666-8	1989	There was overall a significant linear relation between serum creatinine and plasma ANF (r = 0.527, P less than 0.001).	Creatinine	62-72	natriuretic peptide A	Homo sapiens	84-87
2635250-3	1989	Creatinine clearance declined to 75% (88 ml.min-1) of the resting values for all three exercises.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
2527663-10	1989	Among the diabetic patients, ANF was directly related to HbA1 (r = 0.49, P less than 0.005) and urinary albumin excretion (r = 0.40, P less than 0.02), and was inversely related to PRA (r = 0.36, P less than 0.04) and plasma creatinine (r = -0.42, P less than 0.02).	Creatinine	225-235	natriuretic peptide A	Homo sapiens	29-32
2782944-5	1989	Four workers had clinically elevated activity of NAG (greater than 4 mU/mg creatinine) in any of their urine collections after baseline.	Creatinine	75-85	N-acetyl-alpha-glucosaminidase	Homo sapiens	49-52
2788617-3	1989	Urinary IL-2-IN activity ranged between 0 and 1.97 units/mg urine creatinine (U/mg u.c.).	Creatinine	66-76	interleukin 2	Homo sapiens	8-12
2556952-6	1989	MEASUREMENTS: Serum immunoreactive osteocalcin: hydroxylapatite binding (HAB) capacity of serum immunoreactive osteocalcin; excretion of calcium, hydroxyproline, and creatinine in the urine during the last 2 h of a 16-h fasting period.	Creatinine	166-176	bone gamma-carboxyglutamate protein	Homo sapiens	35-46
2636655-11	1989	There were positive correlations between the GFR and the serum transferrin and creatinine:height ratio.	Creatinine	79-89	transferrin	Homo sapiens	63-74
2586008-4	1989	A significant relationship was also found between TATI and serum creatinine levels.	Creatinine	65-75	serine peptidase inhibitor Kazal type 1	Homo sapiens	50-54
2789924-5	1989	The best fit to the data was obtained when drug clearance (1 h-1) was related linearly to creatinine clearance (proportionality constant: 0.059 +/- 0.002 x CLcr (ml min-1)) and initial volume of distribution (1) was related linearly to body weight (proportionality constant: 0.327 +/- 0.014 x body weight (kg)).	Creatinine	90-100	CD59 molecule (CD59 blood group)	Homo sapiens	165-171
2591065-11	1989	A significant increase in 24 h UGH occurred in the post-menopausal women given cyclical oestrogen replacement therapy (9.7 +/- 2.6 (mean +/- SE) to 24.6 +/- 1.0 muIU/mmol creatinine, P less than 0.02), reflecting the increase in their mean 24 h serum GH levels (0.8 +/- 0.3 to 5.3 +/- 0.7 mIU/l, P less than 0.01).	Creatinine	171-181	growth hormone 1	Homo sapiens	32-34
2591065-12	1989	Twenty-four hour UGH increased from 4.6 +/- 0.6 to 17.1 +/- 2.1 muIU/mmol creatinine (P less than 0.002) in the men given biosynthetic GH.	Creatinine	74-84	growth hormone 1	Homo sapiens	18-20
2656961-6	1989	For children whose initial creatinine clearance was less than 100 ml/min/1.75 m2, creatinine clearance also improved significantly (57.5 +/- 11 to 121 +/- 24.5 ml/min/1.75 m2; p less than 0.05).	Creatinine	27-37	CD59 molecule (CD59 blood group)	Homo sapiens	163-168
2736884-12	1989	ANG II also reduced fractional distal delivery [(sodium clearance plus free water clearance) divided by creatinine clearance], another measure of proximal tubular outflow.	Creatinine	104-114	angiotensinogen	Homo sapiens	0-6
2656961-6	1989	For children whose initial creatinine clearance was less than 100 ml/min/1.75 m2, creatinine clearance also improved significantly (57.5 +/- 11 to 121 +/- 24.5 ml/min/1.75 m2; p less than 0.05).	Creatinine	82-92	CD59 molecule (CD59 blood group)	Homo sapiens	69-74
2656961-6	1989	For children whose initial creatinine clearance was less than 100 ml/min/1.75 m2, creatinine clearance also improved significantly (57.5 +/- 11 to 121 +/- 24.5 ml/min/1.75 m2; p less than 0.05).	Creatinine	82-92	CD59 molecule (CD59 blood group)	Homo sapiens	163-168
2795975-6	1989	The ANP level and the creatinine clearance showed significant negative correlation, indicating that one of the reasons for impaired renal function among aged patients could be the decreased ANP level in blood.	Creatinine	22-32	natriuretic peptide A	Homo sapiens	190-193
2706418-3	1989	This increase in AlS was significantly (0.025 less than p less than 0.05) correlated with the pretreatment serum creatinine level (mean value for the whole group 80.5 (SEM 4.7) mumol/l) but showed no correlation with the predicted creatinine clearance.	Creatinine	113-123	superoxide dismutase 1	Homo sapiens	17-20
2706418-3	1989	This increase in AlS was significantly (0.025 less than p less than 0.05) correlated with the pretreatment serum creatinine level (mean value for the whole group 80.5 (SEM 4.7) mumol/l) but showed no correlation with the predicted creatinine clearance.	Creatinine	231-241	superoxide dismutase 1	Homo sapiens	17-20
2929062-1	1989	Lysozyme in the urine in concentrations greater than 3 micrograms per milligram of creatinine reflects renal tubular disease or dysfunction in patients without bowel disease or leukemia.	Creatinine	83-93	lysozyme	Homo sapiens	0-8
2523266-4	1989	Moreover, a negative correlation was found between plasma ANP levels and creatinine clearance.	Creatinine	73-83	natriuretic peptide A	Homo sapiens	58-61
2527765-8	1989	On the other hand, a positive correlation (r = 0.65, p less than 0.05) between alpha hANP and creatinine in blood was found only in the group of chronic renal failure before maintenance hemodialysis.	Creatinine	94-104	natriuretic peptide A	Homo sapiens	85-89
2522705-6	1989	Angiotensin II and arginine vasopressin during basal conditions were significantly higher before than after the operation (angiotensin II: 17 (median) to 10 pmol/l, P less than 0.02; arginine vasopressin: 2.9 to 1.9 pmol/l, P less than 0.01), whereas aldosterone, atrial natriuretic peptide, and creatinine clearance were unchanged.	Creatinine	296-306	angiotensinogen	Homo sapiens	0-14
2649143-9	1989	The age adjusted mean urinary NAG excretion showed a significant rise with urinary cadmium of above 3 micrograms/g creatinine.	Creatinine	115-125	N-acetyl-alpha-glucosaminidase	Homo sapiens	30-33
2783983-5	1989	The over-all peak serum creatinine values and the percentage increase of serum creatinine over baseline for all patients studied were significantly higher in cycle 2 of interleukin-2 therapy than in cycle 1: 3.8 +/- 0.2 versus 2.6 +/- 0.1 mg. per dl.	Creatinine	24-34	interleukin 2	Homo sapiens	169-182
2783983-5	1989	The over-all peak serum creatinine values and the percentage increase of serum creatinine over baseline for all patients studied were significantly higher in cycle 2 of interleukin-2 therapy than in cycle 1: 3.8 +/- 0.2 versus 2.6 +/- 0.1 mg. per dl.	Creatinine	79-89	interleukin 2	Homo sapiens	169-182
2644824-4	1989	Moreover, the decline in the reciprocal of serum creatinine over time observed during triple drug therapy was arrested during therapy with the ACE inhibitor.	Creatinine	49-59	angiotensin I converting enzyme	Homo sapiens	143-146
2918959-0	1989	Erythropoietin treatment: influence of haemoglobin concentration on dialyser creatinine clearance in haemodialysed patients.	Creatinine	77-87	erythropoietin	Homo sapiens	0-14
2919032-9	1989	This was confirmed by the exaggerated response to frusemide reflected by urinary flow measurements in patients with a creatinine clearance of 10 ml min-1 or less.	Creatinine	118-128	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
2475310-4	1989	The ratios of amylase clearance to creatinine clearance (Cam/Ccr) and S-type clearance to creatinine clearance (Cs-amy/Ccr) rose significantly in ESRD(Cam/Ccr: 5.7 +/- 0.6%; Cs-amy/Ccr: 4.3 +/- 0.55%) compared to controls (Cam/Ccr: 3.2 +/- 0.24%, P less than 0.01; Cs-amy/Ccr: 2.1 +/- 0.17%, P less than 0.01).	Creatinine	90-100	calmodulin 3	Homo sapiens	151-154
2475310-4	1989	The ratios of amylase clearance to creatinine clearance (Cam/Ccr) and S-type clearance to creatinine clearance (Cs-amy/Ccr) rose significantly in ESRD(Cam/Ccr: 5.7 +/- 0.6%; Cs-amy/Ccr: 4.3 +/- 0.55%) compared to controls (Cam/Ccr: 3.2 +/- 0.24%, P less than 0.01; Cs-amy/Ccr: 2.1 +/- 0.17%, P less than 0.01).	Creatinine	90-100	calmodulin 3	Homo sapiens	151-154
2521490-5	1989	Renal plasma ANF clearance in human subjects was 78 +/- 12 ml/min per kidney and correlated well with each kidney"s creatinine clearance (r = 0.58, P less than 0.05).	Creatinine	116-126	natriuretic peptide A	Homo sapiens	13-16
2715368-2	1989	The terminal elimination half-life was significantly prolonged in subjects with a creatinine clearance (ClCr) less than 30 mL/min/1.73 m2 (19.2 +/- 16.8 h) compared to 3.7 +/- 1.9 h in subjects with a ClCr greater than 80 mL/min/1.73 m2.	Creatinine	82-92	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
2670141-3	1989	In group I patients with normal i-PTH serum level had an significant lower serum level of creatinine than Group II with elevated abnormal i-PTH.	Creatinine	90-100	parathyroid hormone	Homo sapiens	34-37
2541802-3	1989	Levels of urinary and nephrogenous cAMP (expressed both as a function of creatinine excretion as well as glomerular filtration rate) rose from birth to 1 year of age, whereas plasma cAMP levels did not change significantly.	Creatinine	73-83	cathelicidin antimicrobial peptide	Homo sapiens	35-39
2527539-6	1989	There was a significant correlation between ACE inhibition at 24 h and creatinine clearance (CrCL).	Creatinine	71-81	angiotensin I converting enzyme	Homo sapiens	44-47
2702965-3	1989	Mean creatinine clearance of the healthy subjects was 129.7 +/- 3.3 ml min-1 (mean +/- SEM), that of the patients was 25.6 +/- 20.4 ml min-1.	Creatinine	5-15	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
2737228-6	1989	Endogenous creatinine clearance normalized to 70 kg in burned children was 190 ml.min-1.	Creatinine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
2473351-3	1989	In a multivariate analysis, plasma ANP was independently and positively related to age (p less than 0.001), urinary sodium excretion (p less than 0.01), and inversely related to creatinine clearance (p less than 0.02).These variables explained more than 12% of the variability of plasma levels of ANP.	Creatinine	178-188	natriuretic peptide A	Homo sapiens	35-38
2628691-4	1989	The concentration of mercury in blood and urine of 15 +/- 13 micrograms l-1 and 44 +/- 43 micrograms x g creatinine-1, respectively was found.	Creatinine	105-115	immunoglobulin kappa variable 1-16	Homo sapiens	72-82
2533973-5	1989	In healthy volunteers, however, the same dose of ANF increased urinary excretion of sodium, potassium, calcium, chloride and phosphorus as well as water, and creatinine clearances, and decreased plasma aldosterone.	Creatinine	158-168	natriuretic peptide A	Homo sapiens	49-52
2544817-4	1989	On the control day, creatinine clearance increased from 114.3 +/- 4.7 before the meal to 137.1 +/- 4.7 ml/min/1.73 m2 after the meal (p less than 0.001).	Creatinine	20-30	CD59 molecule (CD59 blood group)	Homo sapiens	106-111
2565539-3	1989	The mean NAG value corrected for creatinine in the higher cadmium group (2.95 U/g creatinine) is significantly different from the mean low cadmium group value (0.92 U/g creatinine, p = 0.0083).	Creatinine	82-92	N-acetyl-alpha-glucosaminidase	Homo sapiens	9-12
2565539-3	1989	The mean NAG value corrected for creatinine in the higher cadmium group (2.95 U/g creatinine) is significantly different from the mean low cadmium group value (0.92 U/g creatinine, p = 0.0083).	Creatinine	82-92	N-acetyl-alpha-glucosaminidase	Homo sapiens	9-12
2565539-9	1989	The analysis of this relationship gives estimates of a 10% chance of observing an elevated NAG value at a cadmium level of 6.3 micrograms/g creatinine (8.0 micrograms/l) and a 10% chance of observing an elevated AAP at a cadmium level of 5.0 micrograms/g creatinine (3.4 micrograms/l).	Creatinine	140-150	N-acetyl-alpha-glucosaminidase	Homo sapiens	91-94
2454413-4	1988	Transplant patients with normal kidney function (creatinine 1.25 +/- 0.1 mg/dl) showed significantly lower PSTI values (16.7 +/- 2.1 ng/ml) than transplant patients with impaired renal function (creatinine 4.7 +/- 0.5 mg/dl; PSTI 72.8 +/- 11.8 ng/ml; p less than 0.01).	Creatinine	49-59	serine peptidase inhibitor Kazal type 1	Homo sapiens	107-111
3291531-7	1988	Excretion rate of C-peptide fell progressively from basal (11.2 +/- 4.2 nmol/12 h) to a nadir value of 1.3 +/- 0.8 nmol/12 h (P less than 0.0005); similarly, the C-peptide to creatinine clearance ratio fell from 0.062 +/- 0.035 to 0.028 +/- 0.015 (P less than 0.05).	Creatinine	175-185	insulin	Homo sapiens	18-27
3131046-3	1988	A close correlation was found between serum concentration of free A-1 and creatinine in patients with varying degrees of chronic renal failure (r = 0.717, p less than 0.001).	Creatinine	74-84	BCL2 related protein A1	Homo sapiens	66-69
3242582-8	1988	Creatinine clearances for the 21 patients ranged from 6-162 ml min-1.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	63-68
2847885-3	1988	In the patients with renal parenchymal hypertension, plasma ANP correlated negatively with creatinine clearance (r = -0.76, p less than 0.001).	Creatinine	91-101	natriuretic peptide A	Homo sapiens	60-63
3243040-7	1988	In contrast, creatinine clearances (mean +/- SEM, ml/min/1.73 m2) in men significantly decreased over both 1 year (110 +/- 4 to 95 +/- 5, n = 21, p = 0.0126) and 3 years (107 +/- 4 to 80 +/- 11, n = 8, p = 0.0385) of evaluation.	Creatinine	13-23	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
2975995-4	1988	Atrial natriuretic factor caused a significant increase in sodium excretion (UNaV) [+56%], urinary flow rate (V) [+17%] and free water clearance (CH2O) [+23%]; creatinine clearance (Ccr) did not change.	Creatinine	160-170	natriuretic peptide A	Homo sapiens	0-25
2855193-6	1988	The urinary calcium-creatinine ratio (0.74 compared with 0.034 in controls) was increased (p less than 0.03) in mice infused with PTHrP (5.0 micrograms/day), but the urinary phosphorus-creatinine ratio was not different from that in controls.	Creatinine	20-30	parathyroid hormone-like peptide	Mus musculus	130-135
2855193-6	1988	The urinary calcium-creatinine ratio (0.74 compared with 0.034 in controls) was increased (p less than 0.03) in mice infused with PTHrP (5.0 micrograms/day), but the urinary phosphorus-creatinine ratio was not different from that in controls.	Creatinine	185-195	parathyroid hormone-like peptide	Mus musculus	130-135
2855193-7	1988	The urinary cAMP-creatinine ratio was increased (1.6-fold) in mice infused with PTHrP (5.0 micrograms/day).	Creatinine	17-27	parathyroid hormone-like peptide	Mus musculus	80-85
3241258-8	1988	Urinary calcium (creatinine) was negatively correlated with SBP in males, and with SBP and DBP in the south.	Creatinine	17-27	D-box binding PAR bZIP transcription factor	Homo sapiens	91-94
3241258-10	1988	Urinary potassium (creatinine) was negatively correlated with DBP only in the south.	Creatinine	19-29	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
3263237-4	1988	The median nadir urinary uric acid to urinary creatinine ratio during IL-2 therapy was 0.2.	Creatinine	46-56	interleukin 2	Homo sapiens	70-74
3180518-3	1988	The MANOVA analysis (multivariate analysis of variance) showed that all 3 considered factors (sex, age, creatinine) have a systematic effect on PRL values, that of creatinine being the most prominent.	Creatinine	104-114	prolactin	Homo sapiens	144-147
3180518-3	1988	The MANOVA analysis (multivariate analysis of variance) showed that all 3 considered factors (sex, age, creatinine) have a systematic effect on PRL values, that of creatinine being the most prominent.	Creatinine	164-174	prolactin	Homo sapiens	144-147
3064276-2	1988	With increasing urine flow rate the amount of lysozyme excreted per hour or per millimole creatinine increased more markedly than that of beta 2-microglobulin while at the same time the excretion rate of ribonuclease decreased.	Creatinine	90-100	lysozyme	Homo sapiens	46-54
3342732-4	1988	In type I diabetics, mean creatinine clearance was inversely related to systolic blood pressure (P less than 0.001), glycosylated haemoglobin (P less than 0.05), fasting plasma glucose (P less than 0.05) and to the renal clearance of albumin (P less than 0.001), transferrin (P less than 0.01) and IgG (P less than 0.05).	Creatinine	26-36	transferrin	Homo sapiens	263-274
3069478-8	1988	A linear correlation was found between creatinine clearance and the renal clearance of the ceftazidime, the mean values being 108 and 95 ml.min-1, respectively.	Creatinine	39-49	CD59 molecule (CD59 blood group)	Homo sapiens	140-145
2821056-10	1987	alpha hANP also increased urine volume [176 +/- 31 (+/- SEM) vs. 113 +/- 19 mL/mmol creatinine with placebo; P less than 0.03] and sodium excretion (2.14 +/- 0.48 vs. 0.58 +/- 0.22 mmol/mmol creatinine with placebo; P less than 0.004) on the ACTH infusion days.	Creatinine	84-94	natriuretic peptide A	Homo sapiens	6-10
2970166-7	1988	In this subgroup, increased creatinine clearance tended to be found more frequently among patients with increased hANP levels.	Creatinine	28-38	natriuretic peptide A	Homo sapiens	114-118
2890304-3	1987	The median urinary concentrations of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase in women without preeclampsia increased progressively through the first, second, and third trimesters and reached maximum values of 1.12 and 0.77 U/mmol creatinine, respectively.	Creatinine	249-259	carboxypeptidase Q	Homo sapiens	81-95
2821091-5	1987	By stepwise logistic analysis, only hyponatremia (or an elevated plasma renin activity) and enalapril therapy independently predicted the decline in creatinine clearance during converting enzyme inhibition.	Creatinine	149-159	renin	Homo sapiens	72-77
2821056-10	1987	alpha hANP also increased urine volume [176 +/- 31 (+/- SEM) vs. 113 +/- 19 mL/mmol creatinine with placebo; P less than 0.03] and sodium excretion (2.14 +/- 0.48 vs. 0.58 +/- 0.22 mmol/mmol creatinine with placebo; P less than 0.004) on the ACTH infusion days.	Creatinine	191-201	natriuretic peptide A	Homo sapiens	6-10
2821056-11	1987	With angiotensin II, urine volume was also significantly increased by alpha hANP (150 +/- 27 vs. 81 +/- 15 mL/mmol creatinine with placebo; P less than 0.03), and urine sodium excretion doubled.	Creatinine	115-125	angiotensinogen	Homo sapiens	5-19
3621614-4	1987	However, apo A-IV was significantly correlated with serum creatinine, BUN, and beta 2-microglobulin levels (p less than 0.05) in the patients.	Creatinine	58-68	apolipoprotein A4	Homo sapiens	9-17
3672075-5	1987	In high risk patients it is therefore recommended that serum creatinine be checked after initiating therapy with an ACE inhibitor.	Creatinine	61-71	angiotensin I converting enzyme	Homo sapiens	116-119
3037893-9	1987	Significant correlations between serum creatinine levels and plasma renin activity have been observed.	Creatinine	39-49	renin	Homo sapiens	68-73
3300293-5	1987	In 23 patients receiving CyA in whom the serum creatinine concentration was less than 2.0 mg/dL, the mean DTPA clearance was 49.5 +/- 2.83 mL/min/1.73 m2.	Creatinine	47-57	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
3304720-5	1987	The molecular weight of hIL-1 beta in normal urine was shown to be 17,000 by gel filtration, and levels of urine hIL-1 beta in healthy subjects aged 19-87 yr were 0-146 ng/1 or 0-88 ng/g of creatinine.	Creatinine	190-200	interleukin 1 beta	Homo sapiens	24-34
3304720-5	1987	The molecular weight of hIL-1 beta in normal urine was shown to be 17,000 by gel filtration, and levels of urine hIL-1 beta in healthy subjects aged 19-87 yr were 0-146 ng/1 or 0-88 ng/g of creatinine.	Creatinine	190-200	interleukin 1 beta	Homo sapiens	113-123
3297497-3	1987	A significant improvement in creatinine clearance was seen when the perfusate was treated with superoxide dismutase (SOD) and catalase (CAT), with values of 261 +/- 82 ml/hr vs control values of 203 +/- 72 ml/hr, P less than 0.05.	Creatinine	29-39	catalase	Oryctolagus cuniculus	126-134
3297497-3	1987	A significant improvement in creatinine clearance was seen when the perfusate was treated with superoxide dismutase (SOD) and catalase (CAT), with values of 261 +/- 82 ml/hr vs control values of 203 +/- 72 ml/hr, P less than 0.05.	Creatinine	29-39	catalase	Oryctolagus cuniculus	136-139
3552792-3	1987	Urinary insulin-to-creatinine clearance ratio in the proband and her affected family members was 0.22 X 10(-3) +/- 0.07 (mean +/- SD, n = 4) and was markedly reduced compared with those of other groups: 1.73 X 10(-3) in two unaffected family members, 2.77 X 10(-3) in two other hyperinsulinemic patients with obesity, 2.99 X 10(-3) +/- 1.48 in five non-insulin-dependent diabetic patients, and 2.54 X 10(-3) +/- 0.67 in five normal control subjects.	Creatinine	19-29	insulin	Homo sapiens	8-15
3496655-9	1987	Non-linear regression analysis showed that plasma BGP was within the normal range when 24-h creatinine clearance was greater than 30 ml/min, and large increases in plasma BGP did not occur until the 24-h creatinine clearance was below 20 ml/min.	Creatinine	92-102	bone gamma-carboxyglutamate protein	Homo sapiens	50-53
3496655-9	1987	Non-linear regression analysis showed that plasma BGP was within the normal range when 24-h creatinine clearance was greater than 30 ml/min, and large increases in plasma BGP did not occur until the 24-h creatinine clearance was below 20 ml/min.	Creatinine	204-214	bone gamma-carboxyglutamate protein	Homo sapiens	171-174
3552792-3	1987	Urinary insulin-to-creatinine clearance ratio in the proband and her affected family members was 0.22 X 10(-3) +/- 0.07 (mean +/- SD, n = 4) and was markedly reduced compared with those of other groups: 1.73 X 10(-3) in two unaffected family members, 2.77 X 10(-3) in two other hyperinsulinemic patients with obesity, 2.99 X 10(-3) +/- 1.48 in five non-insulin-dependent diabetic patients, and 2.54 X 10(-3) +/- 0.67 in five normal control subjects.	Creatinine	19-29	insulin	Homo sapiens	283-290
2435656-7	1987	The Mg2+ infusion produced a significant increase in the excretion of the stable prostaglandin I2 (PGI2) metabolite 6-keto-PGF1 alpha (from 96 +/- 12 to 154 +/- 16 ng/g creatinine; p less than 0.01).	Creatinine	169-179	mucolipin TRP cation channel 1	Homo sapiens	4-7
2951044-3	1987	In 13 non-HD patients with serum creatinine values from 2.0 to 8.3 mg/dl, mean plasma hANP (+/- SE) was 404 +/- 23 pg/ml, while it was 236 +/- 11 pg/ml in the normal control group (n = 15) and the difference was significant (p less than 0.001).	Creatinine	33-43	natriuretic peptide A	Homo sapiens	86-90
3670226-5	1987	When the C-PTH values were plotted against the logarithm of creatinine clearance values, both groups showed a significant linear relationship reflecting the progressive increase in PTH when GFR fell.	Creatinine	60-70	parathyroid hormone	Homo sapiens	181-184
3788870-6	1987	The effects of calcitriol on renal function were tested by creatinine clearance values, which were 127 +/- 22 mL/min/1.73 m2 (2.12 +/- 0.37 mL/s/1.73 m2) at the conclusion of the study, compared with 128 +/- 25 mL/min/1.73 m2 (2.13 +/- 0.41 mL/s/1.73 m2) obtained at the initiation of calcitriol therapy.	Creatinine	59-69	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
3110677-2	1987	Met-enkephalin was markedly higher (P less than 0.001) in uraemic patients than in a group of 13 normal subjects, and was directly related to plasma creatinine (r = 0.60; P less than 0.01) and to plasma urea (r = 0.36; P = 0.06).	Creatinine	149-159	proopiomelanocortin	Homo sapiens	0-14
3498115-6	1987	There was a significant (r = 0.84, p less than 0.001) positive correlation between serum BGP and serum creatinine for the nonhemodialysis group alone, but not for hemodialysis patients alone.	Creatinine	103-113	bone gamma-carboxyglutamate protein	Homo sapiens	89-92
3685911-5	1987	The difference in AlS levels might be due not only to the intestinal absorption of Al from Al-containing drugs, but also to a slightly impaired renal function, serum creatinine being slightly but significantly higher (p less than 0.05) in the Al-treated RA group than in non-Al-treated one.	Creatinine	166-176	superoxide dismutase 1	Homo sapiens	18-21
2431086-1	1986	The mechanism of the increased renal clearance of amylase and the amylase to creatinine clearance ratio (CAM/CCR) in acute pancreatitis remains controversial with both renal tubular dysfunction and altered glomerular permeability being invoked as explanations.	Creatinine	77-87	calmodulin 3	Homo sapiens	105-108
3534324-8	1986	The ratio of the end-diastolic to peak systolic velocities in the renal artery (EDR) tended to decrease with increasing serum creatinine levels, presumably because renal vascular resistance increases with end-stage parenchymal disease.	Creatinine	126-136	paternally expressed 10	Homo sapiens	80-83
3019586-3	1986	Among the 29 patients with a pretreatment renal perfusion pressure under 70 mm Hg, patients with preserved renal function (creatinine clearance greater than 50 ml/min/1.73 m2) had markedly elevated values for plasma renin activity (11.8 +/- 3.8 ng/ml/hr) and showed a significant decline in creatinine clearance after converting-enzyme inhibition (61.1 +/- 3.0 to 45.9 +/- 5.3 ml/min/1.73 m2; p less than .05).	Creatinine	123-133	renin	Homo sapiens	216-221
3019586-3	1986	Among the 29 patients with a pretreatment renal perfusion pressure under 70 mm Hg, patients with preserved renal function (creatinine clearance greater than 50 ml/min/1.73 m2) had markedly elevated values for plasma renin activity (11.8 +/- 3.8 ng/ml/hr) and showed a significant decline in creatinine clearance after converting-enzyme inhibition (61.1 +/- 3.0 to 45.9 +/- 5.3 ml/min/1.73 m2; p less than .05).	Creatinine	291-301	renin	Homo sapiens	216-221
3019586-4	1986	In contrast, although similar with respect to all pretreatment demographic, hemodynamic, and clinical variables, patients with a creatinine clearance under 50 ml/min/1.73 m2 had low values for plasma renin activity (3.4 +/- 0.8 ng/ml/hr) and, despite similar drug-induced decreases in systemic blood pressure, showed no change in creatinine clearance after therapy with captopril or enalapril (32.6 +/- 2.5 to 41.4 +/- 3.8 ml/min/1.73 m2).	Creatinine	129-139	CD59 molecule (CD59 blood group)	Homo sapiens	162-167
3019586-4	1986	In contrast, although similar with respect to all pretreatment demographic, hemodynamic, and clinical variables, patients with a creatinine clearance under 50 ml/min/1.73 m2 had low values for plasma renin activity (3.4 +/- 0.8 ng/ml/hr) and, despite similar drug-induced decreases in systemic blood pressure, showed no change in creatinine clearance after therapy with captopril or enalapril (32.6 +/- 2.5 to 41.4 +/- 3.8 ml/min/1.73 m2).	Creatinine	129-139	renin	Homo sapiens	200-205
3019586-4	1986	In contrast, although similar with respect to all pretreatment demographic, hemodynamic, and clinical variables, patients with a creatinine clearance under 50 ml/min/1.73 m2 had low values for plasma renin activity (3.4 +/- 0.8 ng/ml/hr) and, despite similar drug-induced decreases in systemic blood pressure, showed no change in creatinine clearance after therapy with captopril or enalapril (32.6 +/- 2.5 to 41.4 +/- 3.8 ml/min/1.73 m2).	Creatinine	129-139	CD59 molecule (CD59 blood group)	Homo sapiens	426-431
3019586-5	1986	Changes in creatinine clearance varied linearly and inversely with pretreatment values for plasma renin activity (r = - .64, p less than .001); converting-enzyme inhibition effectively abolished the pretreatment difference in renal function seen in the high- and low-renin subgroups.	Creatinine	11-21	renin	Homo sapiens	98-103
3019586-5	1986	Changes in creatinine clearance varied linearly and inversely with pretreatment values for plasma renin activity (r = - .64, p less than .001); converting-enzyme inhibition effectively abolished the pretreatment difference in renal function seen in the high- and low-renin subgroups.	Creatinine	11-21	renin	Homo sapiens	267-272
3530612-7	1986	Creatinine adjusted rates of whole body glucose disposal were 30-40% lower in the myotonic dystrophy group at all three doses of insulin compared with the normals.	Creatinine	0-10	insulin	Homo sapiens	129-136
3089817-2	1986	In fifty-three patients with decreased kidney function plasma VIP was significantly increased (median 15.0 pmol l-1, range 0.5-70, P less than 0.0001) and positively correlated to serum creatinine concentration (r = 0.51, P less than 0.001).	Creatinine	186-196	vasoactive intestinal peptide	Homo sapiens	62-65
3524197-4	1986	Parathyroid hormone assays and studies of urinary calcium excretion, especially the calcium-creatinine clearance ratio, distinguish parathyroid hormone excess from hypocalciuric forms of hypercalcemia.	Creatinine	92-102	parathyroid hormone	Homo sapiens	132-151
3740319-4	1986	Urinary and metabolic clearances of AVP also increased linearly with the maximum urinary clearance being 60.6% of the creatinine clearance.	Creatinine	118-128	arginine vasopressin	Homo sapiens	36-39
3488088-3	1986	There was a positive correlation between osteocalcin and fasting mucopolysaccharide/creatinine ratio in both sexes, and between osteocalcin and fasting hydroxyproline/creatinine ratio in women.	Creatinine	84-94	bone gamma-carboxyglutamate protein	Homo sapiens	41-52
3734452-5	1986	With control for age, body mass index and pulse in multivariate analyses, only the relationship of Na:K and Na:creatinine to SBP and DBP remained significant for men; a similar, though less strong and consistent, trend was found for women, and K was inversely related to SBP for women.	Creatinine	111-121	D-box binding PAR bZIP transcription factor	Homo sapiens	133-136
3789636-3	1986	Urine concentration, however, was an important variable as NAG concentration (per mL urine) and lysozyme excretion (per mumol creatinine) were significantly elevated and reduced, respectively, in samples with a higher specific gravity.	Creatinine	126-136	lysozyme	Homo sapiens	96-104
3514728-3	1986	Plasma vasopressin concentration correlated with the percent decrease of systemic vascular resistance (r = 0.70, p less than 0.025), serum sodium (r = 0.72, p less than 0.02) and serum creatinine (r = 0.85, p less than 0.005).	Creatinine	185-195	arginine vasopressin	Homo sapiens	7-18
3514728-6	1986	Levels of plasma renin activity ranged between 1 and 46 ng/ml per h (average 14.7 +/- 5.7) and correlated with serum sodium (r = 0.77, p less than 0.025), serum creatinine (r = 0.73, p less than 0.025) and right atrial pressure (r = 0.67, p less than 0.05).	Creatinine	161-171	renin	Homo sapiens	17-22
3510938-8	1986	Finally, creatinine clearance corrected excretion of PGI-M, as an estimation of relative plasma levels correlates both with plasma renin activity and plasma aldosterone in the 31 subjects who presented with ascites.	Creatinine	9-19	renin	Homo sapiens	131-136
2943055-5	1986	Plasma ANP level was conversely correlated with creatinine clearance (r = -0.812, p less than 0.001) in patients with renal diseases (n = 29).	Creatinine	48-58	natriuretic peptide A	Homo sapiens	7-10
3079774-6	1986	A positive correlation was found between the DIs of total and little PRL and creatinine clearance in group CRF.	Creatinine	77-87	prolactin	Homo sapiens	69-72
3484903-7	1986	A positive correlation (r = 0.907, p less than 0.002) was also demonstrated between the maximal prolactin response and the 5-hydroxyindoleacetic acid/creatinine ratio.	Creatinine	150-160	prolactin	Homo sapiens	96-105
3540692-3	1986	Significant correlations between high serum creatinine values and low plasma FN levels were found in renal transplant patients.	Creatinine	44-54	fibronectin 1	Homo sapiens	77-79
3080101-7	1986	Mean (SEM) plasma creatinine concentration rose slightly in the insulin infusion group only (93 (5) to 109 (11) mumol/l (1.1 (0.06) to 1.2 (0.1) mg/100 ml), 0.1 greater than p greater than 0.05; controls 94 (6) to 96 (6) mumol/l (1.1 (0.07) and 1.1 (0.07) mg/100 ml].	Creatinine	18-28	insulin	Homo sapiens	64-71
3742714-5	1986	The change in serum creatinine from baseline to peak correlated inversely with pretreatment serum albumin (r = -0.73; P less than 0.01) and with pretreatment uric acid (r = 0.76; P less than 0.01).	Creatinine	20-30	albumin	Homo sapiens	98-105
3154426-4	1986	In rather small numbers of patients, the daily average serum creatinine values were not different with HLA-DR mismatching and HLA-B,DR mismatching, but were lower in the better matched transplants for the HLA-A,B loci and the HLA-A,B,DR loci.	Creatinine	61-71	major histocompatibility complex, class I, A	Homo sapiens	205-212
3154426-4	1986	In rather small numbers of patients, the daily average serum creatinine values were not different with HLA-DR mismatching and HLA-B,DR mismatching, but were lower in the better matched transplants for the HLA-A,B loci and the HLA-A,B,DR loci.	Creatinine	61-71	major histocompatibility complex, class I, A	Homo sapiens	226-233
3714354-4	1986	Mean urine vasopressin was higher in the assisted ventilation group on the first day (360 +/- 86 versus 123 +/- 30 pg/mg creatinine; p less than 0.02) and correlated with higher urine osmolality.	Creatinine	121-131	arginine vasopressin	Homo sapiens	11-22
3528886-5	1986	Changes in creatinine were markedly higher in cases with bilateral renal artery stenosis and/or in those with a very high initial plasma renin activity (greater than 15 ng/ml X 3 h).	Creatinine	11-21	renin	Homo sapiens	137-142
3904407-4	1985	At follow-up, the group mean (+/- SD) serum creatinine concentration in 14 patients with functioning grafts was nearly double the expected mean value for normal children of similar age and sex (1.13 +/- 0.38 vs 0.61 +/- 0.07 mg/dL), and the mean +/- SD glomerular filtration rate was 76.5 +/- 20.0 mL/min/1.73 sq m (range, 40 to 115.5 mL/min/1.73 sq m).	Creatinine	44-54	CD59 molecule (CD59 blood group)	Homo sapiens	301-306
2998675-3	1985	In six patients with plasma creatinine levels greater than or equal to 3 mg/dl, aldosterone excretion decreased after 4 weeks of captopril, from 7.5 +/- 3.1 to 1.8 +/- 0.5 micrograms/24 hr, whereas plasma renin activity increased from 0.6 +/- 0.2 to 4.4 +/- 1.1 ng/ml/hr (P less than 0.05).	Creatinine	28-38	renin	Homo sapiens	205-210
4085913-1	1985	An infusion with Ornipressin (8-ornithin vasopressin) in a patient with decompensated alcoholic liver cirrhosis increased urinary volume from 30 ml/h to 500 ml/h, creatinine clearance from 24 to 65 ml/min, and fractional sodium excretion from 0.86% to 11.1%.	Creatinine	163-173	arginine vasopressin	Homo sapiens	41-52
3904407-4	1985	At follow-up, the group mean (+/- SD) serum creatinine concentration in 14 patients with functioning grafts was nearly double the expected mean value for normal children of similar age and sex (1.13 +/- 0.38 vs 0.61 +/- 0.07 mg/dL), and the mean +/- SD glomerular filtration rate was 76.5 +/- 20.0 mL/min/1.73 sq m (range, 40 to 115.5 mL/min/1.73 sq m).	Creatinine	44-54	CD59 molecule (CD59 blood group)	Homo sapiens	338-343
3878905-6	1985	In the untreated patients, serum BGP was higher than normal and showed a positive correlation with creatinine levels (P less than 0.001).	Creatinine	99-109	bone gamma-carboxyglutamate protein	Homo sapiens	33-36
3903090-3	1985	Creatinine clearance was less than or equal to 80 ml/min/1.73 m2 in four patients.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
4094035-1	1985	The effects of administration of angiotensin II (ANG II) and antidiuretic hormone (ADH) on the glomerular filtration rate (GFR, measured as creatinine clearance) were examined in patients with mesangial proliferation.	Creatinine	140-150	arginine vasopressin	Homo sapiens	83-86
3008050-9	1985	Normal creatinine clearance range in children (80 to 120 ml min-1/1.73 m2) allowed determination of normal uptake range (36 to 60%).	Creatinine	7-17	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
2860493-3	1985	The average creatinine clearance was 83.9 +/- 16.5 ml/min/1.73 m2 or 74.3% of that in healthy controls with two kidneys; it was a value similar to that reported 3 to 6 months postnephrectomy in kidney donors.	Creatinine	12-22	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
3981057-7	1985	The mean serum erythropoietin concentration was significantly (P less than 0.025) higher in children with anemia of renal disease (32.4 +/- 2.4 mU/ml) in comparison with serum values in normal children (19.6 +/- 1.5 mU/ml), but serum erythropoietin levels did not correlate with hematocrit level, creatinine clearance, or serum inhibition of in vitro erythropoiesis.	Creatinine	297-307	erythropoietin	Homo sapiens	15-29
3891172-6	1985	Close positive correlations between angiotensin II and plasma levels of urea and creatinine (P less than 0.01) were observed.	Creatinine	81-91	angiotensinogen	Homo sapiens	36-50
3987216-6	1985	For volunteers with a creatinine clearance of less than 15 mL/min/1.73 sq m, the mean half-life was 15.6 hours.	Creatinine	22-32	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
3987216-7	1985	For subjects with a creatinine clearance of 31-60 mL/min/1.73 sq m, the mean half-life was 11.9 hours.	Creatinine	20-30	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
2857638-5	1985	Injection of PTH (15 U/kg iv) produced an increase in U cAMP from 1.7 +/- 0.3 to 7.4 +/- 0.7 nmol cAMP/mumol creatinine (n = 6), (P less than 0.001).	Creatinine	109-119	parathyroid hormone	Rattus norvegicus	13-16
2857638-7	1985	Infusion of the alpha 2-adrenergic agonist clonidine at 1 microgram/kg X min caused a decrease in the cAMP response to PTH to 3.6 +/- 0.5 nmol cAMP/mumol creatinine (n = 12) (P less than 0.001).	Creatinine	154-164	parathyroid hormone	Rattus norvegicus	119-122
3973451-1	1985	We reported in a previous paper that the pattern of change in the lysozyme content of normal amniotic fluid during pregnancy resembles indices of fetal maturity such as L/S ratio, creatinine concentration and amylase activity.	Creatinine	180-190	lysozyme	Homo sapiens	66-74
3873250-6	1985	Creatinine clearance (GFR) declined by 0.9 ml/min/yr and correlated with both BGP (r = -0.21, P less than 0.001) and AP (r = -0.21, P less than 0.001).	Creatinine	0-10	bone gamma-carboxyglutamate protein	Homo sapiens	78-81
3873250-9	1985	In 48 patients with known parenchymal renal disease studied for comparison, plasma BGP was increased at a serum creatinine of greater than or equal to 1.8 mg/dl.	Creatinine	112-122	bone gamma-carboxyglutamate protein	Homo sapiens	83-86
2988827-4	1985	ACTH increased water consumption, Na+ and K+ excretion and creatinine clearance by the 4th day of infusion and these effects were not significantly altered when adrenaline was also infused.	Creatinine	59-69	proopiomelanocortin	Canis lupus familiaris	0-4
3880820-5	1985	Currently the group mean (+/- SE) serum creatinine concentration is 1.22 +/- 0.11 mg/dl and creatinine clearance is 69.3 +/- 4.79 ml/min/1.73 m2.	Creatinine	92-102	CD59 molecule (CD59 blood group)	Homo sapiens	133-138
6520066-4	1984	In five patients with a creatinine clearance greater than 1 ml min-1 kg-1, a mean plasma elimination half-life of 7.8 +/- 2.8 h was calculated.	Creatinine	24-34	CD59 molecule (CD59 blood group)	Homo sapiens	63-73
6501997-2	1984	In patients with renal insufficiency not receiving dialysis, a significant curvilinear relationship between serum parathyroid hormone and creatinine concentrations was present (r = 65, p less than 0.001).	Creatinine	138-148	parathyroid hormone	Homo sapiens	114-133
6501997-5	1984	On the other hand, when a restricted population of patients with creatinine values between 1 and 4 mg/dl was analyzed separately, controlling for the effect of creatinine, there was still a significant correlation between hematocrit level and m-parathyroid hormone, but no such relationship was seen when participants with parathyroid hormone levels of less than or equal to 1000 pg/ml were analyzed.	Creatinine	65-75	parathyroid hormone	Homo sapiens	245-264
6363436-4	1984	In five patients with primary hyperaldosteronism, PGI-M fell from 199 +/- 34 ng g creatinine-1 preoperatively to 120 +/- 26 pg/mg creatinine-1 after removal of the adenoma.	Creatinine	82-92	biglycan	Homo sapiens	50-53
6743589-4	1984	The correlation between the increase in TTCA concentrations during the workshift and the atmospheric CS2 concentrations was found to be higher when urine samples at the end of the workshift with creatinine concentrations below 1 mg/ml and above 3 mg/ml were disregarded (from r = 0.61; n = 20 to r = 0.84; n = 14).	Creatinine	195-205	chorionic somatomammotropin hormone 2	Homo sapiens	101-104
6499094-0	1984	Elimination of creatinine following intravenous administration to chronically CCl4-treated rats.	Creatinine	15-25	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
6741518-1	1984	Plasma branched-chain amino acids and urinary C-peptide-creatinine excretion was determined at 3, 4 1/2 and 6 months of age in a group of 50 infants who were either breast-fed or artificially fed and selected at random.	Creatinine	56-66	insulin	Homo sapiens	46-55
6741518-3	1984	Plasma valine values correlated significantly with the urinary C-peptide/creatinine ratio (r = 0.76, p less than 0.01), which suggests that the enhanced insulin response induced by the artificial formula is related to its protein content.	Creatinine	73-83	insulin	Homo sapiens	153-160
3899461-5	1985	The correlation of initial pressure with plasma insulin remained significant even when allowing for age, surface area, BMI, and plasma concentrations of glucose, urea, creatinine, sodium and urate.	Creatinine	168-178	insulin	Homo sapiens	48-55
6387263-8	1984	Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml X 3 h were compared separately.	Creatinine	122-132	renin	Homo sapiens	171-176
6377004-13	1984	Although not important as a prognostic factor on its own, the NSE index significantly improved the prognostic performance of serum Cr.	Creatinine	131-133	enolase 2	Homo sapiens	62-65
6323289-5	1984	In the case of treated females, urinary c-AMP/creatinine also showed a decrease and recovery in 1 wk but no subsequent decrease was observed.	Creatinine	46-56	cathelicidin antimicrobial peptide	Rattus norvegicus	40-45
6363436-4	1984	In five patients with primary hyperaldosteronism, PGI-M fell from 199 +/- 34 ng g creatinine-1 preoperatively to 120 +/- 26 pg/mg creatinine-1 after removal of the adenoma.	Creatinine	130-140	biglycan	Homo sapiens	50-53
6416853-5	1983	Before treatment, plasma parathyroid hormone was related to plasma creatinine but not to 25-hydroxyvitamin D, and the change in absorption on treatment correlated inversely with plasma creatinine.	Creatinine	67-77	parathyroid hormone	Homo sapiens	25-44
6630414-3	1983	The urinary CT level ranged from 420-1000 pg/mg creatinine (Cr; mean +/- SD, 631 +/- 229) in PHP (n = 6), from 50-270 (131 +/- 92) in IHP (n = 6), and from 35-93 (66 +/- 27) in SHP (n = 6), and was 185 pg/mg Cr in one patient with PPHP.	Creatinine	48-58	calcitonin related polypeptide alpha	Homo sapiens	12-14
6630414-3	1983	The urinary CT level ranged from 420-1000 pg/mg creatinine (Cr; mean +/- SD, 631 +/- 229) in PHP (n = 6), from 50-270 (131 +/- 92) in IHP (n = 6), and from 35-93 (66 +/- 27) in SHP (n = 6), and was 185 pg/mg Cr in one patient with PPHP.	Creatinine	60-62	calcitonin related polypeptide alpha	Homo sapiens	12-14
6630414-5	1983	In each patient with PHP and IHP before and after treatment with 1 alpha-hydroxycholecalciferol, urinary CT levels fluctuated between 700-1370 pg/mg Cr in PHP and from 43-195 pg/mg Cr in IHP.	Creatinine	149-151	calcitonin related polypeptide alpha	Homo sapiens	105-107
6630414-5	1983	In each patient with PHP and IHP before and after treatment with 1 alpha-hydroxycholecalciferol, urinary CT levels fluctuated between 700-1370 pg/mg Cr in PHP and from 43-195 pg/mg Cr in IHP.	Creatinine	181-183	calcitonin related polypeptide alpha	Homo sapiens	105-107
6190763-5	1983	In the reference population, the median urinary concentration of TATI was 22 micrograms/g creatinine and the central 95% reference interval was 7-50 micrograms/g creatinine.	Creatinine	90-100	serine peptidase inhibitor Kazal type 1	Homo sapiens	65-69
6190763-7	1983	The highest urinary TATI level (11,000 micrograms/g creatinine) was over 200 times the upper limit of the reference range.	Creatinine	52-62	serine peptidase inhibitor Kazal type 1	Homo sapiens	20-24
6618768-3	1983	The patient"s creatinine clearance decreased from 25 ml/min/1.73 m2 to 10-13 ml/min/1.73 m2 following the acute nephritic episode and chronic dialysis therapy was required thereafter.	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
6618768-3	1983	The patient"s creatinine clearance decreased from 25 ml/min/1.73 m2 to 10-13 ml/min/1.73 m2 following the acute nephritic episode and chronic dialysis therapy was required thereafter.	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
6881896-3	1983	The highest mean urinary cortisol/creatinine ratio (UCCR) was found in subjects after an insulin tolerance test (ITT).	Creatinine	34-44	insulin	Homo sapiens	89-96
6645209-3	1983	However, after furosemide infusion the calcium/creatinine ratio is no longer lower in FHH than in PHP (1.12 vs. 1.14, respectively, P greater than 0.05).	Creatinine	47-57	calcium sensing receptor	Homo sapiens	86-89
6604833-5	1983	Serum levels of bone Gla protein (BGP), a biochemical marker for bone metabolism, correlated negatively with 1/serum creatinine (r = -0.39, P less than 0.02) and positively with PTH (r = 0.57, P less than 0.001) and age (r = 0.33, P less than 0.05).	Creatinine	117-127	bone gamma-carboxyglutamate protein	Homo sapiens	16-32
6604833-5	1983	Serum levels of bone Gla protein (BGP), a biochemical marker for bone metabolism, correlated negatively with 1/serum creatinine (r = -0.39, P less than 0.02) and positively with PTH (r = 0.57, P less than 0.001) and age (r = 0.33, P less than 0.05).	Creatinine	117-127	bone gamma-carboxyglutamate protein	Homo sapiens	34-37
6347435-1	1983	The ratio between urinary clearance of cathodic trypsin-like immunoreactivity and creatinine clearance (CTr/CCr ratio) was evaluated as a test for pancreatic cancer in patients with chronic pancreatic diseases and gastrointestinal diseases clinically mistakable for pancreatic cancer.	Creatinine	82-92	calcitonin receptor	Homo sapiens	104-107
6369515-5	1983	Renin and angiotensin II levels were both related to creatinine clearance, which was often reduced, but it is not clear as to which was cause and which effect.	Creatinine	53-63	renin	Homo sapiens	0-5
6369515-5	1983	Renin and angiotensin II levels were both related to creatinine clearance, which was often reduced, but it is not clear as to which was cause and which effect.	Creatinine	53-63	angiotensinogen	Homo sapiens	10-24
6601547-4	1983	The ratio of urinary Gla/creatinine as a function of age parallels the pattern of serum osteocalcin.	Creatinine	25-35	bone gamma-carboxyglutamate protein	Homo sapiens	88-99
6822131-5	1983	The changes in renin activity correlated significantly (p less than 0.01) with the small changes in endogenous creatinine clearance (r = 0.84).	Creatinine	111-121	renin	Homo sapiens	15-20
6341140-5	1983	There was a good correlation between the levels of plasma C-peptide and urinary C-peptide values as related to creatinine (r = 0.89; p = less than 0.001).	Creatinine	111-121	insulin	Homo sapiens	58-67
6341140-5	1983	There was a good correlation between the levels of plasma C-peptide and urinary C-peptide values as related to creatinine (r = 0.89; p = less than 0.001).	Creatinine	111-121	insulin	Homo sapiens	80-89
6840929-2	1983	The half-life of CPIB was prolonged in proportion to the serum creatinine level (r = 0.818 p less than 0.001).	Creatinine	63-73	cystatin B	Homo sapiens	17-21
6292254-3	1983	PTH stimulated nephrogenous cAMP [185 +/- 31 nmol/100 ml glomerular filtrate (GF)], cyclic guanosine monophosphate (0.44 +/- 0.09 mumol/g creatinine), and phosphate (367 +/- 59 mg P/g creatinine) excretion.	Creatinine	138-148	parathyroid hormone	Homo sapiens	0-3
6292254-3	1983	PTH stimulated nephrogenous cAMP [185 +/- 31 nmol/100 ml glomerular filtrate (GF)], cyclic guanosine monophosphate (0.44 +/- 0.09 mumol/g creatinine), and phosphate (367 +/- 59 mg P/g creatinine) excretion.	Creatinine	184-194	parathyroid hormone	Homo sapiens	0-3
6180850-5	1982	Urine values varied between 3.8 and 7121 micrograms colipase/g creatinine; in serum levels up to 664 micrograms/1 were found.	Creatinine	63-73	colipase	Homo sapiens	52-60
7172448-2	1982	Larger amounts were found in serum from patients with impaired renal function, and there was a good correlation between serum creatinine and serum CuZn superoxide dismutase content.	Creatinine	126-136	superoxide dismutase 1	Homo sapiens	147-172
6878259-4	1983	CAPD treatment was terminated as renal function improved and a creatinine clearance of 20 ml/min/1.73m2 was achieved.	Creatinine	63-73	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
7151647-7	1982	SOD levels varied directly with serum creatinine levels obtained at the time of SOD administration but other factors such as skin perfusion were not controlled.	Creatinine	38-48	superoxide dismutase 1	Homo sapiens	0-3
6754152-4	1982	Creatinine clearance, albumin concentration and hematocrit were lower in low renin patients than in patients with medium renin activity.	Creatinine	0-10	renin	Homo sapiens	77-82
7072619-1	1982	The present study shows that growth hormone administration to 30 growth hormone-deficient children significantly increased their hair zinc concentration (147.0 +/- 31.9 micrograms/ml before, and 168.7 +/- 30.4 micrograms/g after) and decreased their urinary zinc excretion (514 +/- 170 micrograms/g creatine before and 353 +/- 162 micrograms/g creatinine after), suggesting a role for growth hormone in zinc metabolism in children.	Creatinine	344-354	growth hormone 1	Homo sapiens	29-43
7151647-7	1982	SOD levels varied directly with serum creatinine levels obtained at the time of SOD administration but other factors such as skin perfusion were not controlled.	Creatinine	38-48	superoxide dismutase 1	Homo sapiens	80-83
6751731-0	1981	Urine cortisol/creatinine ratio in controlled insulin-induced hypoglycemia.	Creatinine	15-25	insulin	Homo sapiens	46-53
7084275-9	1982	Under such conditions, it seems advisable to reduce the dose to one-half only in patients with a creatinine clearance of less than 10-20 ml/min/1.73 m2.	Creatinine	97-107	CD59 molecule (CD59 blood group)	Homo sapiens	140-145
7032555-7	1981	Decreases in creatinine clearance correlated with lower blood pressure during captopril and were most obvious in patients with high baseline plasma renin activity.	Creatinine	13-23	renin	Homo sapiens	148-153
7329141-2	1981	Urine N-Acetyl-b-d-glucosaminidase (NAG) was expressed in units/mg creatinine in urine.	Creatinine	67-77	N-acetyl-alpha-glucosaminidase	Homo sapiens	6-34
7329141-2	1981	Urine N-Acetyl-b-d-glucosaminidase (NAG) was expressed in units/mg creatinine in urine.	Creatinine	67-77	N-acetyl-alpha-glucosaminidase	Homo sapiens	36-39
7288550-7	1981	On the other hand, k10 was larger in creatinine.	Creatinine	37-47	keratin 10	Rattus norvegicus	19-22
7467586-2	1980	The application of thiazides, which possess a long-term effect, is indicated only up to a value of the creatinine clearance of about 25 ml/min/1.73 m2.	Creatinine	103-113	CD59 molecule (CD59 blood group)	Homo sapiens	139-144
6788125-7	1981	Haemoglobin concentration was strongly correlated with creatinine clearance (r=0.70), particularly with clearances below 100 ml/min/1.73 m2 (r=0.96; p less than 0.001).	Creatinine	55-65	CD59 molecule (CD59 blood group)	Homo sapiens	128-133
6259595-6	1981	With microbiological assay, the elimination serum half-life (T 1/2) increased in patients according to their degree of renal insufficiency and reached 10 hours when creatinine clearance fell below 10 ml.min-1.	Creatinine	165-175	CD59 molecule (CD59 blood group)	Homo sapiens	203-208
7323650-3	1981	Serum calcitonin was increased in most of the studied patients, especially in the dialysed ones and with a creatinine clearance below 10 ml/min.	Creatinine	107-117	calcitonin related polypeptide alpha	Homo sapiens	6-16
6180066-3	1981	About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells.	Creatinine	68-78	interferon alpha 1	Homo sapiens	22-31
6180066-3	1981	About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells.	Creatinine	68-78	interferon alpha 1	Homo sapiens	22-25
7219641-4	1981	Creatinine clearance was related to age, serum albumin and hematocrit.	Creatinine	0-10	albumin	Homo sapiens	41-54
6109414-4	1980	Before the corresponding increase of the serum creatinine we could establish an increase of the enzyme activity in the alanine aminopeptidase in 45% and in the lactate dehydrogenase in 65% of the cases.	Creatinine	47-57	carboxypeptidase Q	Homo sapiens	127-141
6998798-2	1980	--In patients without albuminuria intravenous injection of insulin resulted in changes similar to but less pronounced than those previously observed in short-term diabetics: albumin excretion, plasma noradrenaline and heart rate increased, creatinine excretion decreased significantly.	Creatinine	240-250	insulin	Homo sapiens	59-66
6998798-6	1980	There was a marked decrease in urinary excretion rates of beta-2-microglobulin and creatinine (55 and 17 per cent, respectively) after insulin.	Creatinine	83-93	insulin	Homo sapiens	135-142
6153508-3	1980	The Cam/Ccr% was lower (p less than 0.05) throughout pregnancy and was a function of increased creatinine clearance.	Creatinine	95-105	calmodulin 3	Homo sapiens	4-7
474191-3	1979	In the non-dialysed patient group a highly significant inverse correlation was found between serum calcitonin and creatinine clearance.	Creatinine	114-124	calcitonin related polypeptide alpha	Homo sapiens	99-109
227300-6	1979	Sequential creatinine clearances were reduced to 74 to 90 mL/min.1.73 m2 in five patients for the duration of follow-up.	Creatinine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
542182-0	1979	[Plasma creatinine determination by means of the Greiner selective analyzer GSA II with special attention to the glomerular filtrate].	Creatinine	8-18	GNAS complex locus	Homo sapiens	76-79
7337425-4	1981	The levels of enzyme activities of arginase, ornithine transcarbamoylase, aspartate aminotransferase and alanine aminotransferase were also found to be significantly increased along with that of urea and creatinine, The possible role of GGTI on the altered levels of the above-mentioned parameters is discussed.	Creatinine	204-214	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	74-100
6243611-3	1980	Furthermore, plasma concentrations of PTH and glucagon correlated with the serum creatinine concentration to a significant extent.	Creatinine	81-91	parathyroid hormone	Homo sapiens	38-41
7385802-3	1980	Lysozyme level in urine is in a correlation dependence on serum creatinine level.	Creatinine	64-74	lysozyme	Homo sapiens	0-8
525074-5	1979	Despite the in most cases not measurable lysozyme concentrations in the haemofiltrate a decrease of the serum lysozyme level taking place parallel to creatinine could be proved during dialysis.	Creatinine	150-160	lysozyme	Homo sapiens	110-118
455818-3	1979	In 2 who developed acute renal failure without porto-systemic encephalopathy, plasma renin activity was noted to rise before serum creatinine and to return to initial levels after 3 or 4 days while renal failure persisted.	Creatinine	131-141	renin	Homo sapiens	85-90
762789-2	1979	Progression of renal failure, represented by rising serum creatinine concentrations, was correlated with progressive elevation of serum parathyroid hormone (PTH) concentrations in 23 children.	Creatinine	58-68	parathyroid hormone	Homo sapiens	136-155
696180-6	1978	Creatinine clearance during the first 3 days of life increased from 5.3 to 21.9 ml/min/1.73 m2.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	83-88
637662-7	1978	When the clearance was less than 10 ml/min/1.73 m2, the urinary creatinine excretion for children under the age of 2 was 58% of the normal for the age and for children over 2, it was 86% of the expected mean.	Creatinine	64-74	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
709894-4	1978	A significant correlation was observed between prolactin and creatinine concentrations in these patients (r = 0.45 P less than 0.005) and prolactin reverted towards normal after successful renal transplantation.	Creatinine	61-71	prolactin	Homo sapiens	47-56
709894-7	1978	The positive correlation between prolactin and creatinine reversion of prolactin towards normal after successful transplantation and arteriovenous hormone concentration differences across the normal kidney suggests that the kidney has a important role in prolactin metabolism.	Creatinine	47-57	prolactin	Homo sapiens	71-80
709894-7	1978	The positive correlation between prolactin and creatinine reversion of prolactin towards normal after successful transplantation and arteriovenous hormone concentration differences across the normal kidney suggests that the kidney has a important role in prolactin metabolism.	Creatinine	47-57	prolactin	Homo sapiens	71-80
663820-7	1978	Patients with the greatest increase in creatinine clearance showed the largest rise in substrate concentration and fall in renin and aldosterone secretion, suggesting a dynamic relationship between these factors.	Creatinine	39-49	renin	Homo sapiens	123-128
84347-3	1978	In relation to endogenous clearance of creatinine the clearance of transferrin, IgG and alpha2-macroglobulin increased significantly.	Creatinine	39-49	transferrin	Homo sapiens	67-78
556365-3	1978	The experiences with this case suggest that, if the creatinine clearance is decreased in an insulin-dependent patient irrespective of the serum creatinine value, one must be aware of the possible hazard of acute renal failure and irreversible renal damage following the IVP.	Creatinine	52-62	insulin	Homo sapiens	92-99
336168-3	1977	A patient is described who had a baseline creatinine clearance of about 35 mL/min-1.73 m2 and two successful pregnancies.	Creatinine	42-52	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
918844-4	1977	The renal amylase clearance to creatinine clearance (CAM/CCR) ratio confirms this hyperamylasemic entity.	Creatinine	31-41	calmodulin 3	Homo sapiens	53-56
207364-5	1978	Creatinine values were closely reflected by the c-AMP levels.	Creatinine	0-10	cathelicidin antimicrobial peptide	Homo sapiens	48-53
328218-6	1977	When the data from the three groups were pooled, plasma calcitonin was found to be inversely correlated with total calcium and directly correlated with plasma creatinine.	Creatinine	159-169	calcitonin related polypeptide alpha	Homo sapiens	56-66
69936-2	1977	Ten of the thirteen patients in shock had raised angiotensin-II concentrations in peripheral blood and acute renal failure manifested by oliguria, increasing serum-creatinine, a urine osmolality of less than 400 mos-mol/kg and a urine/plasma osmolality ratio of less than 1-5.	Creatinine	164-174	angiotensinogen	Homo sapiens	49-63
324138-8	1977	Serum lysozyme levels showed a strong correlation with serum correlation with serum creatinine concentrations.	Creatinine	84-94	lysozyme	Homo sapiens	6-14
327148-4	1977	In patients with a healthy carbohydrate metabolism a clear correlation exists between the concentration of creatinine on the one hand, the creatinine-clearance and the fasting C-peptide concentration respectively the measured amount of C-peptide on the other hand.	Creatinine	107-117	insulin	Homo sapiens	176-185
327148-4	1977	In patients with a healthy carbohydrate metabolism a clear correlation exists between the concentration of creatinine on the one hand, the creatinine-clearance and the fasting C-peptide concentration respectively the measured amount of C-peptide on the other hand.	Creatinine	107-117	insulin	Homo sapiens	236-245
327148-4	1977	In patients with a healthy carbohydrate metabolism a clear correlation exists between the concentration of creatinine on the one hand, the creatinine-clearance and the fasting C-peptide concentration respectively the measured amount of C-peptide on the other hand.	Creatinine	139-149	insulin	Homo sapiens	236-245
870227-3	1977	In this group, hypertension was significantly reduced by the 1-hour intravenous infusion of 1,000 ng/kg of an angiotensin II antagonist or by correcting the volume depletion with a high Na intake, which also decreased renin activity and creatinine.	Creatinine	237-247	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	218-223
5101300-3	1971	The presence of endogenous vasopressin was indicated by the patient"s ability to concentrate the urine to as high as 710 mOsm/kg of water with a creatinine clearance of 84 cc/min, and by dilution of the urine in response to alcohol.	Creatinine	145-155	arginine vasopressin	Homo sapiens	27-38
189549-1	1977	The present studies demonstrate that the administration of pharmacologic amounts of ACTH is associated with small but significant increases in urinary cyclic AMP excretion and in urinary cyclic AMP/creatinine ratios which are most likely related to a release of cyclic AMP from adrenocortical tissue.	Creatinine	198-208	proopiomelanocortin	Homo sapiens	84-88
809852-3	1975	The creatinine height index was more sensitive than other measures of nutritional status in this study, which included weight for height, nitrogen balance and serum albumin levels.	Creatinine	4-14	albumin	Homo sapiens	165-172
239344-3	1975	Treatment during the last nine weeks of gestation with large doses of vitamin B12 given to the mother reversed the increasing maternal excretion of methylmalonic acid, which was 23 mug per milligram of creatinine at 31 weeks" gestation.	Creatinine	202-212	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
1149362-5	1975	When %FD was regressed simultaneously against Alb and Cr or BUN, Alb emerged as the sole determinant of %FD (p less than 0.001), indicating that creatinine or BUN correlated with %FD by their inverse correlation to Alb rather than by an effect on drug protein binding.	Creatinine	145-155	albumin	Homo sapiens	65-68
1149362-5	1975	When %FD was regressed simultaneously against Alb and Cr or BUN, Alb emerged as the sole determinant of %FD (p less than 0.001), indicating that creatinine or BUN correlated with %FD by their inverse correlation to Alb rather than by an effect on drug protein binding.	Creatinine	145-155	albumin	Homo sapiens	65-68
1120781-8	1975	Similarly, infusion of angiotensin II amide led to a significantly increased ipsilateral excretion rate of prostaglandin E2 and F2a in spite of a simultaneous decrease in the creatinine clearance.	Creatinine	175-185	angiotensinogen	Homo sapiens	23-37
1173015-10	1975	Patients with primary hyperparathyroidism and increased S-creatinine had higher PTH levels than those with normal S-creatinine.	Creatinine	58-68	parathyroid hormone	Homo sapiens	80-83
1117758-7	1975	The increase of plasma renin substrate was interpreted as mainly due to the impairment of renal function, since a positive correlation was found between plasma creatinine and plasma renin substrate.	Creatinine	160-170	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	23-28
1117758-7	1975	The increase of plasma renin substrate was interpreted as mainly due to the impairment of renal function, since a positive correlation was found between plasma creatinine and plasma renin substrate.	Creatinine	160-170	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	182-187
1171565-6	1975	Creatinine clearance was studied during calcitonin treatment in 2 patients and showed an increase.	Creatinine	0-10	calcitonin related polypeptide alpha	Homo sapiens	40-50
892276-3	1977	A good correlation between values of creatinine and MD clearances and between their ratio and serum albumin levels was verified.	Creatinine	37-47	albumin	Homo sapiens	100-107
960882-2	1976	It exists a highly significant correlation between the alanine aminopeptidase activity and the creatinine concentration in the urine.	Creatinine	95-105	carboxypeptidase Q	Homo sapiens	63-77
960882-4	1976	The creatinine in the urine may be regarded as a favourable reference parameter for the excretion of alanine aminopeptidase.	Creatinine	4-14	carboxypeptidase Q	Homo sapiens	109-123
940620-4	1976	Parathyroid hormone levels were correlated with the creatinine levels, but the inverse relationship with ionized calcium was not significant.	Creatinine	52-62	parathyroid hormone	Homo sapiens	0-19
935120-1	1976	Hypertensive patients with various renal lesions and a mean plasma creatinine of 2mg/100ml showed increases (p is less than 0.05) in mean exchangeable sodium and plasma renin activity, while blood volume was not altered significantly.	Creatinine	67-77	renin	Homo sapiens	169-174
951347-3	1976	The association of DIP to 4 other fundamental histological varieties of diseases of the pulmonary interstitium (UIP, BIP, LIP, GIP) is at the origin of Liebow"s classification.	Creatinine	19-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	117-120
951347-3	1976	The association of DIP to 4 other fundamental histological varieties of diseases of the pulmonary interstitium (UIP, BIP, LIP, GIP) is at the origin of Liebow"s classification.	Creatinine	19-22	gastric inhibitory polypeptide	Homo sapiens	127-130
6023776-5	1967	Concomitant measurements of endogenous creatinine clearance and the rates of excretion of sodium and potassium suggest that a fall in renal arterial perfusion resulting from upright posture induces increased release of renin and the subsequent secondary stimulation of aldosterone secretion.	Creatinine	39-49	renin	Homo sapiens	219-224
13106045-0	1953	[Research on the ACTH-induced variations in blood iron in relation to the uric acid and creatinine content and the eosinophil count of the blood].	Creatinine	88-98	proopiomelanocortin	Homo sapiens	17-21
20344111-0	1947	Urinary uric acid-creatinine ratio following administration of pituitary adrenocorticotropic hormone (ACTH) as a simple test for adrenal cortical function.	Creatinine	18-28	proopiomelanocortin	Homo sapiens	73-100
20344111-0	1947	Urinary uric acid-creatinine ratio following administration of pituitary adrenocorticotropic hormone (ACTH) as a simple test for adrenal cortical function.	Creatinine	18-28	proopiomelanocortin	Homo sapiens	102-106
33940096-10	2021	CONCLUSION: Although interaction terms are not statistically significant, the associations of temporal patterns of NT-proBNP, HsTnT, and CRP appear more outspoken in women than in men with HFrEF, whereas associations seem similar for temporal patterns of creatinine, eGFR, Cystatin C, KIM-1 and NAG.	Creatinine	255-265	C-reactive protein	Homo sapiens	137-140
32919390-10	2021	1AVERAGE ENRICHMENT OF URINE D3-CREATININE (D3CRN) ENRICHMENT MEASURED FROM URINE-SATURATED FILTER PAPER PLACED IN DIAPERS FROM IMMEDIATELY AFTER DOSING OF D3-CREATINE THROUGH 72 H.: Urine D3Crn enrichment achieved isotopic steady state after ~10 h and remained unchanged through 72 h.Fig.	Creatinine	32-42	iodothyronine deiodinase 3	Homo sapiens	156-167
1193311-0	1975	Relationship between insulin response to oral glucose load and creatinine clearance.	Creatinine	63-73	insulin	Homo sapiens	21-28
1193311-5	1975	Insulin area during oral glucose load increased in proportion to the decrease in creatinine clearance.	Creatinine	81-91	insulin	Homo sapiens	0-7
1193311-6	1975	The ratio of insulin area to glucose area correlated closely with creatinine clearance and a linear relationship was obtained (y = 1.46 - 0.01x, r = -0.82, p less than 0.001).	Creatinine	66-76	insulin	Homo sapiens	13-20
33754453-7	2021	Hs-cTnT was statistically significantly reduced at 12 weeks in a model adjusted for randomization group, centre and VO2peak , and after further adjustment in the final model that also included age, sex, creatinine concentrations, N-terminal pro-brain natriuretic peptide, smoking, and heart failure treatment.	Creatinine	203-213	troponin T2, cardiac type	Homo sapiens	3-7
33850533-6	2021	MPO-AAV patients had higher levels of serum creatinine and proteinuria at baseline.	Creatinine	44-54	myeloperoxidase	Homo sapiens	0-3
34051046-0	2021	Urinary C-peptide/Creatinine Ratio: A Useful Biomarker of Insulin Resistance and Refined Classification of Type 2 Diabetes Mellitus.	Creatinine	18-28	insulin	Homo sapiens	58-65
34051046-1	2021	BACKGROUND: The urinary C-peptide/creatinine ratio (UCPCR) is low in patients with type 1 diabetes (T1DM), but it has not been well characterized in patients with type 2 diabetes (T2DM).	Creatinine	34-44	insulin	Homo sapiens	24-33
34044856-7	2021	The urinary liver-type fatty acid binding protein (L-FABP)/creatinine ratio was significantly decreased at 3 and 6 months after switching to TAF compared with that before switching to TAF (- 0.5 mug/g Cr at 3 months, and - 0.8 mug/g Cr at 6 months; p < 005 for both at 3 and 6 months).	Creatinine	59-69	fatty acid binding protein 1	Homo sapiens	12-49
34044856-7	2021	The urinary liver-type fatty acid binding protein (L-FABP)/creatinine ratio was significantly decreased at 3 and 6 months after switching to TAF compared with that before switching to TAF (- 0.5 mug/g Cr at 3 months, and - 0.8 mug/g Cr at 6 months; p < 005 for both at 3 and 6 months).	Creatinine	59-69	fatty acid binding protein 1	Homo sapiens	51-57
33624028-6	2021	The risk of AKI, CD, and their combination was increased in patients with higher neutrophil count/creatinine (heart rate (HR) = 3.7, 95% cardiac index (CI) 1.9-7.1; HR = 2.7, 95% CI 1.6-4.6; HR = 3.2, 95% CI 2.1-4.9); NL-ratio/creatinine (HR = 2.1, 95% CI 1.6-4.1; HR = 2.2, 95% CI 1.3-3.8; HR = 2.3, 95% CI 1.5-3.5); and hsCRP (HR = 1.8, 95% CI 0.9-3.5; HR = 2.2, 95% CI 1.3-3.6; HR = 1.9, 95% CI 1.2-2.8) after adjustment for age, diabetes, hypertension, previous heart failure, kidney function, haemodynamic instability at admission, statin, and renin-angiotensin-aldosterone antagonists use.	Creatinine	98-108	renin	Homo sapiens	549-554
34029542-4	2021	Our results showed that GAA improved renal damage by decreasing the serum levels of creatinine, urea, uric acid and alleviating kidney fibrosis.	Creatinine	84-94	glucosidase, alpha, acid	Mus musculus	24-27
33377278-12	2021	Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX-2-dependent normalization of creatinine clearance and sodium excretion.	Creatinine	97-107	angiotensinogen	Rattus norvegicus	0-14
33636416-9	2021	Baseline plasma ET-1 levels were associated with older age, higher NT-proBNP levels, higher serum creatinine levels, and higher prevalence of atrial fibrillation.	Creatinine	98-108	endothelin 1	Homo sapiens	16-20
4502451-4	1972	Lysozyme catabolism varied with the endogenous creatinine clearance; in addition however, extrarenal sites of catabolism were demonstrated since lysozyme could be broken down in the anephric patients, although only at a rate amounting to about 15% of the rate found in persons with intact kidneys.	Creatinine	47-57	lysozyme	Homo sapiens	0-8
34020444-7	2021	RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [beta (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (beta = 0.076; 95% CI: 0.042, 0.109), homocysteine (beta = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (beta = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (beta = 0.068; 95% CI: 0.023, 0.114), insulin (beta = 0.068; 95% CI: 0.043, 0.093), and IL-6 (beta = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (beta = -0.146; 95% CI: -0.188, -0.104), insulin (beta = -0.106; 95% CI: -0.130, -0.082), homocysteine (beta = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (beta = -0.074; 95% CI: -0.102, -0.047).	Creatinine	100-110	insulin	Homo sapiens	501-508
34020444-7	2021	RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [beta (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (beta = 0.076; 95% CI: 0.042, 0.109), homocysteine (beta = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (beta = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (beta = 0.068; 95% CI: 0.023, 0.114), insulin (beta = 0.068; 95% CI: 0.043, 0.093), and IL-6 (beta = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (beta = -0.146; 95% CI: -0.188, -0.104), insulin (beta = -0.106; 95% CI: -0.130, -0.082), homocysteine (beta = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (beta = -0.074; 95% CI: -0.102, -0.047).	Creatinine	100-110	interleukin 6	Homo sapiens	551-555
34020444-7	2021	RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [beta (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (beta = 0.076; 95% CI: 0.042, 0.109), homocysteine (beta = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (beta = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (beta = 0.068; 95% CI: 0.023, 0.114), insulin (beta = 0.068; 95% CI: 0.043, 0.093), and IL-6 (beta = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (beta = -0.146; 95% CI: -0.188, -0.104), insulin (beta = -0.106; 95% CI: -0.130, -0.082), homocysteine (beta = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (beta = -0.074; 95% CI: -0.102, -0.047).	Creatinine	100-110	insulin	Homo sapiens	699-706
33988730-6	2021	nPCR significantly correlated with  BW,  BW%,  BMI, spKT/V, and preHD serum creatinine, and negatively correlated with age, DBP SDS (r=-0.466, p=0.025) and RI (r=-0.435, p=0.043).	Creatinine	76-86	nasopharyngeal carcinoma-related protein	Homo sapiens	0-4
33988730-8	2021	At multivariable analysis, nPCR remained positively correlated with creatinine and spKt/V, and inversely correlated with RI.	Creatinine	68-78	nasopharyngeal carcinoma-related protein	Homo sapiens	27-31
33988730-9	2021	CONCLUSIONS: nPCR is a significant predictor of weight change in adolescents on maintenance HD, and seems associated with creatinine and dialysis adequacy.	Creatinine	122-132	nasopharyngeal carcinoma-related protein	Homo sapiens	13-17
33978827-5	2021	eGFR was calculated using both creatinine- and cystatin-based equations.	Creatinine	31-41	epidermal growth factor receptor	Homo sapiens	0-4
33994138-3	2021	The presence of risk factors, including the existence of a renal failure defined by a creatinine clearance (eGFR) of less than 60 mL/min/1.73 m2, requires to take prevention measures including hydration.	Creatinine	86-96	epidermal growth factor receptor	Homo sapiens	108-112
33963937-8	2021	The median urine protein-to-creatinine ratio was 1.24 g/gCr.	Creatinine	28-38	nuclear receptor subfamily 3 group C member 1	Homo sapiens	56-59
33591234-10	2021	Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019).	Creatinine	80-90	C-reactive protein	Homo sapiens	286-304
33834262-3	2021	It is estimated (eGFR) from the serum creatinine, the age and gender of the patient.	Creatinine	38-48	epidermal growth factor receptor	Homo sapiens	17-21
33987209-6	2021	eGFR was calculated according to the combined Creatinine/Cystatin C CKD-EPI formula.	Creatinine	46-56	epidermal growth factor receptor	Homo sapiens	0-4
33894740-12	2021	Delayed cTnT peak (peak cTnT elevated after 24 h after operation) was correlated with lower creatinine clearance rate (69.36 +- 21.67 vs. 82.18 +- 25.17 ml/min/1.73 m2), body mass index (24.35 +- 2.58 vs. 25.27 +- 3.26 kg/m2), less arterial grafts (1.24 +- 0.77 vs. 1.45 +- 0.86), higher EuroSCORE II (2.22 +- 1.12 vs.1.72 +- 0.91) and mid-term mortality (26.5 vs.7.9%).	Creatinine	92-102	troponin T2, cardiac type	Homo sapiens	8-12
33894740-12	2021	Delayed cTnT peak (peak cTnT elevated after 24 h after operation) was correlated with lower creatinine clearance rate (69.36 +- 21.67 vs. 82.18 +- 25.17 ml/min/1.73 m2), body mass index (24.35 +- 2.58 vs. 25.27 +- 3.26 kg/m2), less arterial grafts (1.24 +- 0.77 vs. 1.45 +- 0.86), higher EuroSCORE II (2.22 +- 1.12 vs.1.72 +- 0.91) and mid-term mortality (26.5 vs.7.9%).	Creatinine	92-102	troponin T2, cardiac type	Homo sapiens	24-28
33895898-2	2021	Data regarding measured GFR (mGFR) in this population is restricted to a single study of 77 individuals, which suggested that a GFR estimation (eGFR) method based on creatinine and cystatin C (eGFR-CKiD2) performed better than Schwartz"s equation (eGFR-Schwartz).	Creatinine	166-176	epidermal growth factor receptor	Homo sapiens	144-148
33888780-4	2021	We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation.	Creatinine	100-110	epidermal growth factor receptor	Homo sapiens	117-121
33879836-6	2021	Comparison with 11 plasma biomarkers for age-related disease showed that plasma EC-SOD concentration correlated with adiponectin and estimated glomerular filtration rate with creatinine correction; therefore, we deduced that EC-SOD co-operates with adiponectin and possesses beneficial functions for DM in the Oldest Old.	Creatinine	175-185	superoxide dismutase 3	Homo sapiens	225-231
33882512-5	2021	For in vitro assessment, human renal epithelium HK-2 cells were cultured under serum starvation conditions or with tacrolimus.The administration of SLPI (250 mug/kg, i.p) reduced elevated plasma creatinine and blood urea nitrogen levels, tissue myeloperoxidase content, and acute tubular necrosis induced by kidney damage.	Creatinine	195-205	secretory leukocyte peptidase inhibitor	Homo sapiens	148-152
33953981-7	2021	Albumin creatinine ratio on admission (ACR1) and albumin creatinine ratio after 24 hours (ACR2) were significantly lower in survivors than nonsurvivors (P values were <0.001 for both).	Creatinine	8-18	albumin	Homo sapiens	0-7
33953981-7	2021	Albumin creatinine ratio on admission (ACR1) and albumin creatinine ratio after 24 hours (ACR2) were significantly lower in survivors than nonsurvivors (P values were <0.001 for both).	Creatinine	57-67	albumin	Homo sapiens	49-56
33829897-7	2022	CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2 IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.	Creatinine	275-285	insulin like growth factor binding protein 7	Homo sapiens	75-81
33568433-1	2021	Globally, nearly 10% of the population has chronic kidney disease (CKD), defined as a glomerular filtration rate less than 60 mL/min/1.73 m2 and/or a urinary albumin to creatinine ratio greater than 30 mg/g (3 mg/mmol).	Creatinine	169-179	albumin	Homo sapiens	158-165
33938370-8	2022	Serum catestatin levels had positive correlations with systolic and diastolic blood pressure, urea, uric acid, and creatinine.	Creatinine	115-125	chromogranin A	Homo sapiens	6-16
33558151-5	2021	We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (DeltaeGFR).	Creatinine	43-53	adiponectin, C1Q and collagen domain containing	Homo sapiens	77-81
33904662-4	2021	NHE3 KO kidneys had lower creatinine clearance suggesting reduced GFR, but urinary oxalate excretion rates (micromol/24 h) were similar compared to the WT but doubled when expressed as a ratio of creatinine.	Creatinine	26-36	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	0-4
33904662-4	2021	NHE3 KO kidneys had lower creatinine clearance suggesting reduced GFR, but urinary oxalate excretion rates (micromol/24 h) were similar compared to the WT but doubled when expressed as a ratio of creatinine.	Creatinine	196-206	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	0-4
33706697-7	2021	BTP correlated inversely with residual diuresis (rs = - 0.58, p < 0.001), residual creatinine clearance (ClCr) (rs = - 0.69, p < 0.001) and total urea clearance (Clurea) (rs = - 0.56, p < 0.001).	Creatinine	83-93	prostaglandin D2 synthase	Homo sapiens	0-3
33706697-9	2021	Finally, serum BTP inversely correlated with alterations in residual diuresis (r = - 0.41, p = 0.035) and renal creatinine clearance over time (r = - 0.79, p = p < 0.001).	Creatinine	112-122	prostaglandin D2 synthase	Homo sapiens	15-18
33682262-10	2021	FINDINGS: Comparisons between groups revealed the following clinically relevant results in favor of REG: lower limb muscle strength (mean difference [MD] = -1.99, 95% confidence interval [CI] = -2.77 to -1.21; d = -0.53), distance walked in the 6MWT (MD = -26.27, 95% CI = -45.40 to -7.14; d = -0.46), creatinine (MD = -1.52, 95% CI = -2.49 to -0.54; d = -0.66), and calcium (MD = -0.44, 95% CI = -0.78 to -0.10; d = -0.49).	Creatinine	302-312	regenerating family member 1 alpha	Homo sapiens	100-103
33693944-12	2021	Lower creatinine was predictive of higher sNa correction rate within 24 hours (p=0.01).	Creatinine	6-16	snail family transcriptional repressor 1	Homo sapiens	42-45
33664275-8	2021	Stratified analysis suggested that ZNF76 rs10947540 C carriers were more likely to develop relatively high levels of serum creatinine (Scr) than noncarriers (CC + CT vs. TT, p = 9.94 x 10-4).	Creatinine	123-133	zinc finger protein 76	Homo sapiens	35-40
33459166-4	2021	Slc16a12 KO rats displayed lower plasma and urinary creatinine levels, but GFR was normal.	Creatinine	52-62	solute carrier family 16, member 12	Rattus norvegicus	0-8
33850878-11	2021	However, only ANG II alleviated CLP-induced abnormalities in serum creatinine and lactic acid concentrations, renal blood flow, the renal resistant index, renal histopathology, the production of proinflammatory cytokines, and oxidative stress markers in rats.	Creatinine	67-77	angiotensinogen	Rattus norvegicus	14-20
33752499-7	2021	PEBP4 had higher sensitivity for diagnosis of CKD than common indexes including blood urea nitrogen, creatinine and C-reactive protein.	Creatinine	101-111	phosphatidylethanolamine binding protein 4	Homo sapiens	0-5
31257958-12	2021	Correlation analysis revealed a significant positive correlation of serum CXCL 16 level with serum ALT level (r = 0.320, p &lt;= .001) and serum AST level (r = 0.373, p &lt;= .001) and serum creatinine level (r = 0.279, p = .01) in both groups.	Creatinine	191-201	C-X-C motif chemokine ligand 16	Homo sapiens	74-81
33664330-8	2021	MMP-3 significantly and positively correlated with serum creatinine concentration (r = 0.51, p = 0.011; r = 0.44, p = 0.009; r =  -0.66, p < 0.001) and negatively with eGFR (r =  -0.5, p = 0.012; r =  -0.35, p = 0.039; r =  -0.63, p < 0.001) in the Short R, Long R and Control Groups.	Creatinine	57-67	matrix metallopeptidase 3	Homo sapiens	0-5
33478971-6	2021	EXT1/EXT2-positive patients were significantly younger (P=0.01), had significantly lower serum creatinine levels (P=0.02), were significantly more likely to present with proteinuria >=3.5 g/24 h (P=0.009), and had significantly less chronicity features (glomerulosclerosis, P=0.001 or interstitial fibrosis and tubular atrophy, P<0.001) on kidney biopsy.	Creatinine	95-105	exostosin glycosyltransferase 2	Homo sapiens	5-9
33658826-13	2021	Plasma levels of blood urea nitrogen, creatinine, indoxyl sulfate, IL-1beta and renal tubular injury were increased in mice after renal I/R and were decreased by AST-120 treatment.	Creatinine	38-48	solute carrier family 17 member 5	Homo sapiens	162-165
33654443-7	2021	In the third example, the results from an interventional ARIMA analysis show that numbers of creatinine clearance tests decreased significantly within months of the start of eGFR reporting, with a magnitude of drop equal to -0.93 (95% CI, -1.22 to -0.64) tests per 100,000 adults and a rate of drop equal to 0.97 (95% CI, 0.95 to 0.99) tests per 100,000 per adults per month.	Creatinine	93-103	epidermal growth factor receptor	Homo sapiens	174-178
33611767-1	2022	BACKGROUND: Studies on the association between urinary albumin to creatinine ratio (ACR) and bone mineral density (BMD) are still controversial.	Creatinine	66-76	albumin	Homo sapiens	55-62
33496327-8	2021	IL-10-/- miceshowed a higher survival associated with lower renal damage reflected by reduced plasma urea and creatinine levels than control mice.	Creatinine	110-120	interleukin 10	Mus musculus	0-5
33578883-1	2021	Erroneous conclusions may result from normalization of urine cadmium and N-acetyl-beta-D-glucosaminidase concentrations ([Cd]u and [NAG]u) to the urine creatinine concentration ([cr]u).	Creatinine	152-162	N-acetyl-alpha-glucosaminidase	Homo sapiens	132-135
33547567-6	2021	RESULTS: At week 12, high-fat dieted IL-10 KO mice showed 1) severe lipid accumulation in kidneys, cholesterol elevation (in total, serum kidney) and low-density lipoprotein increasion through the SCAP-SREBP2-LDLr pathway; (2) serious histopathologic alterations showing glomerulosclerosis, tubulointerstitial fibrosis and immune cell infiltration; (3) increased pro-inflammatory cytokines and chemokines expression; (4) enhanced renal fibrosis; and (5) serious functional failure with high serum creatinine and BUN and proteinuria excretion compared to other groups.	Creatinine	497-507	interleukin 10	Mus musculus	37-42
34003905-8	2021	Conclusions: The albumin to creatinine ratio, blood uric acid, blood creatinine, blood albumin, and estimated glomerular filtration rate have significant correlation with the progression of moderate to proliferative DR.	Creatinine	28-38	albumin	Homo sapiens	17-24
33541266-2	2021	CASE PRESENTATION: We report a patient with familial autosomal INF2 mutation manifesting nephritic syndromes and elevated serum creatinine levels.	Creatinine	128-138	inverted formin 2	Homo sapiens	63-67
33613527-11	2020	Cellular immune dysregulation with EBNA-1 immunization in mCD40-LMP1 Tg mice was accompanied by enhanced splenomegaly, increased serum blood urea nitrogen (BUN) and creatinine levels, and elevated anti-dsDNA and antinuclear antibody (ANA) levels (p<0.0001 compared to mCD40 WT mice).	Creatinine	165-175	EBNA-1	Human gammaherpesvirus 4	35-41
33915606-3	2021	Objective: model the relationship between relative changes in hs-cTnT (Deltahs-cTnT) and variations in creatinine (Deltacre) or estimated glomerular filtration rate (DeltaeGFR), using a quantile generalized additive model (qgam).	Creatinine	103-113	troponin T2, cardiac type	Homo sapiens	65-69
33915606-3	2021	Objective: model the relationship between relative changes in hs-cTnT (Deltahs-cTnT) and variations in creatinine (Deltacre) or estimated glomerular filtration rate (DeltaeGFR), using a quantile generalized additive model (qgam).	Creatinine	103-113	troponin T2, cardiac type	Homo sapiens	79-83
32892508-10	2021	Multivariate survival analysis showed that the urinary EGF level was associated with time to doubling of the serum creatinine level (DSCr), a marker of future end-stage kidney disease (ESKD) (hazard ratio 0.88, 95% confidence interval 0.77-0.99, P = 0.045).	Creatinine	115-125	Down syndrome chromosome region	Homo sapiens	133-137
33456520-5	2021	Metabolic parameters, such as low-density lipoprotein-cholesterol, total cholesterol and creatinine levels were higher in the ApoE-/- HD mice compared with those in the ApoE-/- HD + E mice.	Creatinine	89-99	apolipoprotein E	Mus musculus	126-130
32667055-5	2021	The mortality rate was significantly higher in participants with urinary beta2 -MG concentrations >1000 mug/g creatinine (Cr) for men and >300 mug/g Cr for women.	Creatinine	110-120	ATPase H+ transporting V0 subunit a2	Homo sapiens	73-78
32667055-5	2021	The mortality rate was significantly higher in participants with urinary beta2 -MG concentrations >1000 mug/g creatinine (Cr) for men and >300 mug/g Cr for women.	Creatinine	122-124	ATPase H+ transporting V0 subunit a2	Homo sapiens	73-78
33535417-8	2021	Patients with elevated IL-6 presented more frequently with anemia mellitus (64.3% vs. 41.7%; p = 0.046), atrial fibrillation (83.3% vs. 61.9% p = 0.036), dyslipidemia (76.2% vs. 58.2%; p = 0.03), higher creatinine levels (1.35 mg/dL vs. 1.08 mg/dL; p = 0.024), lower glomerular filtration rate (43.6 mL/min/m2 vs. 59.9 mL/min/m2; p = 0.007), and anemia 25% vs. 52.4% p = 0.014.	Creatinine	203-213	interleukin 6	Homo sapiens	23-27
32813143-11	2021	This association between VPO1 and kidney function withstood the multivariable adjustment for traditional CVRF including baseline eGFR and urine albumin-to-creatinine ratio (UACR), (adjOR per one SD VPO1 1.73 (1.14-2.61); p = 0.046).	Creatinine	155-165	peroxidasin	Homo sapiens	25-29
33214214-9	2021	Similarly, in a rat model of ischemia-reperfusion injury, M-DDAH significantly improved renal function as measured by reduction in serum creatinine (vehicle: 3.14{plus minus}0.74 mg/dL vs M-DDAH: 1.1{plus minus}0.75 mg/dL; p<0.01), inflammation and injured tubules (vehicle: 73.1{plus minus}11.1% vs M-DDAH: 22.1{plus minus}18.4%; p<0.001).	Creatinine	137-147	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	60-64
33451753-6	2021	Serum creatinine and urea nitrogen levels, incidence of oliguria, and histological score of tubular necrosis at 24 h after I/R were attenuated by Ang II-pretreatment.	Creatinine	6-16	angiotensinogen	Rattus norvegicus	146-152
33098209-10	2021	Spearman correlation showed a positive correlation between AFP, age, AST, Bilirubin, creatinine, INR.	Creatinine	85-95	alpha fetoprotein	Homo sapiens	59-62
33355379-8	2021	The metabolic characteristics of blood creatinine (CRE) levels were lower in the AngII + Lut group compared with in the AngII group.	Creatinine	39-49	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	81-86
33254398-4	2021	Each unit increase in maternal urinary lead concentration (mug/g creatinine) was associated with reduced IL-10 (beta = -5.93%, 95%CI: -11.82%, -0.03%) and reduced IL-4 levels (beta = -5.62%, 95%CI: -10.44%, -0.80%).	Creatinine	65-75	interleukin 4	Homo sapiens	163-167
33993663-6	2021	The correlation analysis revealed a significant positive correlation between the level of TNF-alpha and uric acid (r<0,000001), between the concentration of TNF-alpha and the content of beta-Cross Laps (degradation products of type I collagen) (r=0,0001), as well as serum creatinine (r=0,002) and urea (p=0,00004) levels.	Creatinine	273-283	tumor necrosis factor	Homo sapiens	157-166
33355379-8	2021	The metabolic characteristics of blood creatinine (CRE) levels were lower in the AngII + Lut group compared with in the AngII group.	Creatinine	51-54	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	81-86
33168411-8	2021	Treatment with BTK inhibitor, Ibrutinib causes attenuation in AKI associated dysfunction in biochemical parameters (serum creatinine/blood urea nitrogen, renal myeloperoxidase activity) and oxidative stress in immune cells and kidney (iNOS/NOX2/lipid peroxides/nitrotyrosine/protein carbonyls).	Creatinine	122-132	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	15-18
33168411-6	2021	Our data reveal that BTK is activated in DCs, neutrophils, and B cells which causes an increase in AKI associated biochemical markers such as serum creatinine/blood urea nitrogen, renal myeloperoxidase activity, and histopathological disturbances in renal tubular structures.	Creatinine	148-158	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	21-24
33120421-14	2021	Continuous subcutaneous insulin infusion was associated independently with lower non-HDL cholesterol and lower urinary albumin/creatinine.	Creatinine	127-137	insulin	Homo sapiens	24-31
33280241-9	2021	Treatment with AhR agonist FICZ significantly alleviated the elevation of serum creatinine and urea in AKI.	Creatinine	80-90	aryl-hydrocarbon receptor	Mus musculus	15-18
33184842-5	2021	CCl4 induced considerable increases (p < .05) in the levels of serum ALT, AST, urea and creatinine, total lipid, and triglycerides coupled with significant reductions (p < .05) in serum antioxidant enzymes and some liver histopathological deformations compared to the negative control (group 1).	Creatinine	88-98	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
32882263-15	2021	Significantly, angiotensin II prevented changes in kidney blood flow, creatinine, and urine output compared to vehicle.	Creatinine	70-80	angiotensinogen	Homo sapiens	15-29
33121989-8	2021	In the UUO-Gas5+/- group, the serum levels of uric acid, serum creatinine, and the urine levels of albumin-to-creatinine ratio were higher.	Creatinine	63-73	growth arrest specific 5	Mus musculus	11-15
33121989-8	2021	In the UUO-Gas5+/- group, the serum levels of uric acid, serum creatinine, and the urine levels of albumin-to-creatinine ratio were higher.	Creatinine	110-120	growth arrest specific 5	Mus musculus	11-15
33129879-8	2021	We found that STZ-induced ATF4 KO mice showed significant improvement in urinary albumin, serum creatinine and blood urea nitrogen and the pathological changes of renal tubulointerstitial fibrosis compared with STZ-induced WT mice.	Creatinine	96-106	activating transcription factor 4	Mus musculus	26-30
33397848-0	2021	Correlation of eGFR By MDRD and CKD-EPI Formula with Creatinine Clearance Estimation in CKD Patients and Healthy Subjects.	Creatinine	53-63	epidermal growth factor receptor	Homo sapiens	15-19
33397848-18	2021	CKD EPI eGFR and MDRD eGFR formula had fairly good correlation with conventional 24 hours creatinine clearance in both CKD patient and healthy subjects, there was even more strong correlation especially in CKD patients.	Creatinine	90-100	epidermal growth factor receptor	Homo sapiens	8-12
33397848-18	2021	CKD EPI eGFR and MDRD eGFR formula had fairly good correlation with conventional 24 hours creatinine clearance in both CKD patient and healthy subjects, there was even more strong correlation especially in CKD patients.	Creatinine	90-100	epidermal growth factor receptor	Homo sapiens	22-26
33362965-0	2020	Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.	Creatinine	69-79	albumin	Homo sapiens	61-68
33348538-9	2020	The method showed optimal precision and accuracy, whereas stability was adequate up to 4 h at 20  C, 24 h at 4  C and 6 months at -20  C. PTH was positively associated with creatinine, phosphorus and IRIS stage.	Creatinine	173-183	parathyroid hormone	Homo sapiens	138-141
33362965-9	2020	Through multivariate analysis, MMP-9/UCr was found to be associated with albumin concentration and albumin to creatinine ratio.	Creatinine	110-120	albumin	Homo sapiens	99-106
33305706-0	2021	Renal Function, Albumin-Creatinine Ratio and Pulse Wave Velocity Predicts Silent Coronary Artery Disease and Renal Outcome in type 2 Diabetic and Prediabetic subjects.	Creatinine	24-34	albumin	Homo sapiens	16-23
33658413-10	2021	According to the results of the one-way regression analysis, it was revealed that in hypertensive patients with a TGF-beta1 value, the most significant interactions are between myocardial mass (MM) (p<0,05), CAVI (p<0,05) and creatinine (p<0,05).	Creatinine	226-236	transforming growth factor beta 1	Homo sapiens	114-123
33305706-3	2021	AIMS: To evaluate the incidence of coronary artery disease (CAD) and the relationship between urinary albumin-creatinine ratio, glomerular filtration rate (GFR) and PWV in type 2 DM with silent CAD.	Creatinine	110-120	albumin	Homo sapiens	102-109
33298030-8	2020	At a cut-off value of 3.43, admission Cr/Alb values were indicative of a worse clinical state, including impaired laboratory test values, APACHE II scores, rates of post-operative complications and re-operation, and mortality (P < 0.05).	Creatinine	38-40	albumin	Homo sapiens	41-44
33276745-8	2020	RESULTS: Compared with sham group, the aortic root of ApoE-/- mice in the UAAS group developed early atherosclerosis, the levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol, serum creatinine and urea nitrogen were also higher than that in the sham group.	Creatinine	208-218	apolipoprotein E	Mus musculus	54-58
33275197-12	2021	Coronary angiography was associated with a 43 times increase in the urinary DKK3/creatinine ratio.	Creatinine	81-91	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	76-80
32682697-1	2020	RATIONALE & OBJECTIVE: In prior research and in practice, the difference between eGFR calculated from cystatin C and from creatinine has not been assessed for clinical significance and relevance.	Creatinine	122-132	epidermal growth factor receptor	Homo sapiens	81-85
32342614-3	2020	CXCL9/creatinine increased in UTI and BKV viremia with or without nephropathy (BKVN) (no UTI/leukocyturia/UTI: -0.10/1.61/2.09, P=0.0001 and no BKV/viremia/BKVN: -0.10/1.90/2.29, P<0.001) as well as CXCL10/creatinine (1.17/2.09/1.98, P<0.0001 and 1.13/2.21/2.51, P<0.001, respectively).	Creatinine	206-216	C-X-C motif chemokine ligand 9	Homo sapiens	0-5
32878689-7	2020	RESULTS: Percent lysis(LY30) on POD1 the t-PA TEG was significantly correlated to change creatinine from pre-op to POD-1(p = 0.006).	Creatinine	89-99	plasminogen activator, tissue type	Homo sapiens	41-45
33261565-11	2020	After adjustment for age, gender, urine albumin/creatinine ratio, diabetes, BMI, CRP, WHR, alcohol consumption, cholesterol and triglycerides, low serum albumin (p < 0.001), haemoglobin (p = 0.012) and bilirubin (p = 0.011) were associated with annual decline in eGFR.	Creatinine	48-58	albumin	Homo sapiens	153-160
32909541-1	2020	We report a unique case of an immunosuppressed 67-year-old female with homozygous Z-allele mutation A1AT deficiency and liver transplant with baseline chronic kidney disease (CKD) stage IIIa with creatinine of 1 mg/dL and glomerular filtration rate (GFR) of 49 mL/min/1.73m2 ~ 6 months before the presentation.	Creatinine	196-206	serpin family A member 1	Homo sapiens	100-104
32896803-9	2020	A number of potential causal relationships were identified, e.g., a negative effect of ICAM-1 on MCP-1, or a positive effect of the level of creatinine on the subsequent VCAM-1 concentration (P < 0.001).	Creatinine	141-151	vascular cell adhesion molecule 1	Homo sapiens	170-176
33256349-7	2020	After adjustment of age, the IGF-I/IGFBP-3 ratio was significantly negatively associated with blood pressure and free thyroxine and positively associated with weight, hemoglobin, creatinine, alanine transferase, fasting glucose, and thyroid stimulating hormone.	Creatinine	179-189	insulin like growth factor 1	Homo sapiens	29-34
32981368-1	2020	Multiple clinical guidelines recommend an ACE (angiotensin-converting enzyme) inhibitor or angiotensin II receptor blocker (ARB) in patients with elevated albuminuria, which can be measured through urine albumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, or dipstick.	Creatinine	215-225	angiotensin I converting enzyme	Homo sapiens	42-45
32981368-1	2020	Multiple clinical guidelines recommend an ACE (angiotensin-converting enzyme) inhibitor or angiotensin II receptor blocker (ARB) in patients with elevated albuminuria, which can be measured through urine albumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, or dipstick.	Creatinine	215-225	angiotensin I converting enzyme	Homo sapiens	47-76
32981368-1	2020	Multiple clinical guidelines recommend an ACE (angiotensin-converting enzyme) inhibitor or angiotensin II receptor blocker (ARB) in patients with elevated albuminuria, which can be measured through urine albumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, or dipstick.	Creatinine	250-260	angiotensin I converting enzyme	Homo sapiens	42-45
32981368-5	2020	We applied similar methods to investigate the association of protein-to-creatinine ratio and dipstick measurement results with the prescription of ACE inhibitor/ARB.	Creatinine	72-82	angiotensin I converting enzyme	Homo sapiens	147-150
33136753-3	2020	METHODS: We evaluated cross-sectional and longitudinal accuracy and bias of eGFR, based on creatinine and cystatin C, relative to disappearance of infused iohexol from plasma (iGFR) in a cohort of participants followed annually for up to 7 years.	Creatinine	91-101	epidermal growth factor receptor	Homo sapiens	76-80
33425103-10	2020	Compared with that in normal mice, the expression of Stim1 in the kidney tissues of LN mice was significantly increased, and Stim1 expression was positively correlated with fibronectin, urine protein, blood urea nitrogen and serum creatinine levels.	Creatinine	231-241	stromal interaction molecule 1	Mus musculus	125-130
33009952-10	2020	When controlling for age and CPR duration, multivariable logistic regression with pre-procedural risk factors identified pre-arrest serum creatinine as an independent predictor of mortality [OR 3.25 (95% CI 1.22-8.70), p = 0.019] and higher pre-arrest serum albumin as protective [OR 0.32 (95% CI 0.14-0.74), p = 0.007].	Creatinine	138-148	albumin	Homo sapiens	252-265
32845540-9	2020	Additionally, miR-146b was negatively correlated with serum creatinine, white blood cell, C-reactive protein, APACHE II score, and SOFA score, while positively correlated with albumin.	Creatinine	60-70	microRNA 146b	Homo sapiens	14-22
32500969-0	2020	A study on the correlation between remnant cholesterol and urinary albumin to creatinine ratio in Chinese community adults: a report from the REACTION study.	Creatinine	78-88	albumin	Homo sapiens	67-74
32500969-1	2020	BACKGROUND: The correlation between remnant cholesterol (RC) and urinary albumin to creatinine ratio (UACR) has not been illustrated.	Creatinine	84-94	albumin	Homo sapiens	73-80
33299497-7	2020	Serum creatinine (P = 0.006) and serum cystatin C (P = 0.001) were positively correlated with serum TNF-alpha level, while albumin (P = 0.014) and eGFR (P = 0.021) were negatively correlated with serum TNF-alpha level.	Creatinine	6-16	tumor necrosis factor	Homo sapiens	100-109
33581704-11	2020	Copeptin was positively correlated with daytime systolic and diastolic load, aldosterone, BNP, and urine microalbumin/creatinine levels (p<0.05).	Creatinine	118-128	arginine vasopressin	Homo sapiens	0-8
33343341-5	2020	While pre-administration of gastrin ameliorated I/R-induced renal pathological damage, as reflected by the levels of serum creatinine and blood urea nitrogen, hematoxylin and eosin staining and periodic acid-Schiff staining.	Creatinine	123-133	gastrin	Mus musculus	28-35
32707041-6	2020	PRMT5 knockdown increased the levels of amino acids and carbohydrates, particularly related to the arginine metabolism such as glutamate, glutamine (Gln), proline, creatine, creatinine and phosphocreatine (PCr).	Creatinine	174-184	protein arginine methyltransferase 5	Homo sapiens	0-5
32730761-13	2020	Spearman"s correlation analysis showed that plasma IL-20 was positively correlated with plasma TNF-alpha and IL-6, D-dimer, C-reaction protein (CRP), creatinine, fasting blood glucose, systolic blood pressure (SBP), and diastolic blood pressure (DBP).	Creatinine	150-160	interleukin 20	Homo sapiens	51-56
32557963-6	2020	A lower-than-median level of serum creatinine (Hazard Ratio [HR] =1.67; 95% confidence interval [CI] =1.31-2.12) or albumin (1.49, 1.13-1.96), whereas a higher-than-median level of log-transformed CRP (1.33, 1.04-1.71) or glucose (1.34, 1.01-1.78), at baseline was associated with a higher mortality risk.	Creatinine	35-45	C-reactive protein	Homo sapiens	197-200
32841436-5	2020	Urine-values of NAG and KIM-1 got related to urinary creatinine.	Creatinine	53-63	N-acetyl-alpha-glucosaminidase	Homo sapiens	16-19
32402458-17	2020	Thirty-five patients with postoperative PTH < 15 pg/mL displayed a mean postoperative creatinine of 5.5 mg/dL (range, 4.3-6.8), similar to other patients.	Creatinine	86-96	parathyroid hormone	Homo sapiens	40-43
33293895-10	2020	Conclusions: Predialysis serum albumin, high-sensitivity C-reactive protein, ferritin, and creatinine were independent correlated factors of EPO responsiveness among maintenance hemodialysis patients.	Creatinine	91-101	erythropoietin	Homo sapiens	141-144
33182592-2	2020	We sought to investigate the impact and threshold value of the hemoglobin to creatinine (Hgb/Cr) ratio, on in-hospital adverse outcomes among non-dialysis patients in a Japanese nationwide registry.	Creatinine	77-87	cytoglobin	Homo sapiens	89-92
33172086-7	2020	In addition, folate and creatinine were elevated in the EVs from prostate and CTCL cancer cell lines.	Creatinine	24-34	TSPY like 2	Homo sapiens	78-82
33171965-5	2020	We performed microarray experiments and identified that ubiquitin protein ligase E3C (UBE3C) is differentially expressed in two DKD patient groups with extreme (low and high) urine protein-to-creatinine ratios.	Creatinine	192-202	ubiquitin protein ligase E3C	Homo sapiens	56-84
33171965-5	2020	We performed microarray experiments and identified that ubiquitin protein ligase E3C (UBE3C) is differentially expressed in two DKD patient groups with extreme (low and high) urine protein-to-creatinine ratios.	Creatinine	192-202	ubiquitin protein ligase E3C	Homo sapiens	86-91
33141880-7	2021	In a cross-sectional analysis, adiponectin was positively associated with urinary albumin:creatinine ratio at baseline (P = 0.009).	Creatinine	90-100	adiponectin, C1Q and collagen domain containing	Homo sapiens	31-42
32952646-9	2020	The concentrations of CD68 and TGF-beta1 in the study group positively correlated with the renal injury indexes, such as blood urea nitrogen (BUN), serum creatinine (SCR), uric acid (UA) and the 24-h urinary protein quantity (P<0.05).	Creatinine	154-164	transforming growth factor beta 1	Homo sapiens	31-40
32968444-10	2020	Additionally, CT genotype at rs1799724 of TNF-alpha gene was related to the 24-h urine protein level (P=0.035), GG genotype at rs1800872 of IL-10 gene was associated with the plasma albumin level (P=0.031), and GG genotype at rs141219090 was related to the serum creatinine level (P=0.047).	Creatinine	263-273	tumor necrosis factor	Homo sapiens	42-51
32524496-4	2020	Preoperative levels of NGF/Cr (0.13 vs 0.08, p = 0.005) and MMP-1/Cr (0.11 vs 0.04, p = 0.021) were predictors of persistent DO 12 months after surgery.	Creatinine	27-29	nerve growth factor	Homo sapiens	23-26
32971570-4	2020	Furthermore, compared to a single ACE2 or Mas KO mice, mice lacking ACE2/Mas developed more severe renal injury including higher levels of serum creatinine and a further reduction in creatinine clearance, and progressive renal inflammation and fibrosis.	Creatinine	145-155	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	68-72
32971570-4	2020	Furthermore, compared to a single ACE2 or Mas KO mice, mice lacking ACE2/Mas developed more severe renal injury including higher levels of serum creatinine and a further reduction in creatinine clearance, and progressive renal inflammation and fibrosis.	Creatinine	183-193	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	68-72
33565431-7	2020	There was a statistically significant positive correlation between SLE disease activity index score, protein/creatinine ratio, and urinary podocalyxin (P <0.001, r = 0.98) (P <0.001, r = 0.765).	Creatinine	109-119	podocalyxin like	Homo sapiens	139-150
33122776-10	2020	S100B concentration was associated with inflammation markers (Ferritin, C-Reactive Protein, Procalcitonin), and organ damage markers (Alanine Aminotransferase, Creatinine).	Creatinine	160-170	S100 calcium binding protein B	Homo sapiens	0-5
33093616-8	2021	For non-CKD patients in ACCORD trial, risk of doubling of serum creatinine (SCr) or >20 mL/min decrease in eGFR among intensive group patients with DBP <= 70 mmHg was significantly higher than the group with DBP between 71 and 85 mmHg (OR = 1.49, 95% CI = 1.12-1.99).	Creatinine	64-74	D-box binding PAR bZIP transcription factor	Homo sapiens	148-151
33093616-8	2021	For non-CKD patients in ACCORD trial, risk of doubling of serum creatinine (SCr) or >20 mL/min decrease in eGFR among intensive group patients with DBP <= 70 mmHg was significantly higher than the group with DBP between 71 and 85 mmHg (OR = 1.49, 95% CI = 1.12-1.99).	Creatinine	64-74	D-box binding PAR bZIP transcription factor	Homo sapiens	208-211
33195588-10	2020	On the other hand, ALT, AST, urea, and creatinine were significantly (P < 0.05) decreased by increasing LZM supplementation.	Creatinine	39-49	lysozyme	Homo sapiens	104-107
32557963-7	2020	Taking all available measurements after ALS diagnosis into account, we found an association between per SD decrease in serum creatinine (2.23, 1.81-2.75) or albumin (1.83, 1.43-2.36) as well as per SD increase of log(CRP) (1.96, 1.58-2.43) or glucose (1.61, 1.21-2.12) and a higher mortality risk.	Creatinine	125-135	C-reactive protein	Homo sapiens	217-220
33134397-11	2020	Plasma levels of GDF-15 and TFF3 were highly positively correlated with serum creatinine levels and 24-hour urine protein levels.	Creatinine	78-88	trefoil factor 3	Homo sapiens	28-32
33083054-13	2020	Conclusions: The combination of plasma NGAL and creatinine D1 on the first day at admission had a high accuracy of predictive model for CRS1.	Creatinine	48-58	twist family bHLH transcription factor 1	Homo sapiens	136-140
33002152-4	2020	Urine albumin to creatinine ratio is a key marker of early renal damage.	Creatinine	17-27	albumin	Homo sapiens	6-13
33002152-11	2020	:: The percentage of urine albumin, creatinine, and albumin to creatinine ratio results for quality assurance point-of-care testing that were within assigned allowable limits of performance averaged 96.9%, 95.9%, and 97.5%, respectively.	Creatinine	63-73	albumin	Homo sapiens	52-59
33002152-15	2020	:: For 16 years the DCA system has proven to be reliable and robust and operators at Aboriginal medical services have demonstrated they are able to conduct point-of-care testing for urine albumin to creatinine ratio that consistently meets analytic performance standards.	Creatinine	199-209	albumin	Homo sapiens	188-195
32430905-3	2020	Familial hypocalcuric hypercalcemia (FHH) is a benign disorder of hypercalcaemia associated with an inappropriately low urinary calcium excretion which is quantified by the calcium creatinine clearance ratio (CCCR).	Creatinine	181-191	calcium sensing receptor	Homo sapiens	37-40
32430905-14	2020	A significant difference in the mean calcium creatinine clearance ratio (CCCR) in those patients with an identified CASR pathogenic variant versus those without (p=0.0001) was demonstrated in this study.	Creatinine	45-55	calcium sensing receptor	Homo sapiens	116-120
31950345-1	2020	This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD).	Creatinine	96-106	microRNA 154	Homo sapiens	62-69
32694216-1	2020	BACKGROUND: Traditionally, clinical trials evaluating effects of a new therapy with creatinine-based renal end points use doubling of serum creatinine (equivalent to a 57% eGFR reduction), requiring large sample sizes.	Creatinine	84-94	epidermal growth factor receptor	Homo sapiens	172-176
32694216-1	2020	BACKGROUND: Traditionally, clinical trials evaluating effects of a new therapy with creatinine-based renal end points use doubling of serum creatinine (equivalent to a 57% eGFR reduction), requiring large sample sizes.	Creatinine	140-150	epidermal growth factor receptor	Homo sapiens	172-176
32688168-3	2020	We aimed to compare the performance of serum cystatin C- and serum creatinine-based eGFR against a reference GFR using 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) in survivors of critical illness.	Creatinine	67-77	epidermal growth factor receptor	Homo sapiens	84-88
32588279-11	2020	The levels of creatinine on discharge day were higher in patients with high Wnt5a levels, compared to those with low Wnt5a levels (P = 0.030); however, no difference in Wnt5a levels was observed on day 0 and 5.	Creatinine	14-24	Wnt family member 5A	Homo sapiens	76-81
33091682-11	2020	Increased plasma CD59 concentrations correlated with decreased platelet count and increased lactate dehydrogenase, creatinine, aspartate transaminase, urine protein/creatinine ratio, systolic blood pressure and diastolic blood pressure (P < 0.01, all correlations).	Creatinine	115-125	CD59 molecule (CD59 blood group)	Homo sapiens	17-21
33091682-11	2020	Increased plasma CD59 concentrations correlated with decreased platelet count and increased lactate dehydrogenase, creatinine, aspartate transaminase, urine protein/creatinine ratio, systolic blood pressure and diastolic blood pressure (P < 0.01, all correlations).	Creatinine	165-175	CD59 molecule (CD59 blood group)	Homo sapiens	17-21
33103102-8	2020	Results: Compared to the control animals, CCl4 administration caused kidney damage as evidenced by significant (P < 0.05) increase in the evaluated indices (urea, creatinine, Na+ and K+).	Creatinine	163-173	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
33063034-16	2020	Compared with controls, angiotensin-II-treated patients had significantly faster improvement in mean arterial pressure, hypercapnia, acidosis, baseline-corrected creatinine, and d-dimer.	Creatinine	162-172	angiotensinogen	Homo sapiens	24-38
32533679-1	2020	OBJECTIVES: This study was conducted to compare the urinary levels of intestinal fatty acid binding protein (I-FABP) and I-FABP: Cr (creatinine) between neonates with necrotising enterocolitis and gestation matched healthy controls.	Creatinine	129-131	fatty acid binding protein 2	Homo sapiens	121-127
32533679-5	2020	Urinary I-FABP: Cr levels of 3.6 pg/mmoL had a sensitivity and specificity of 96% and 99.5%, respectively in diagnosing stage 2/3 NEC.	Creatinine	16-18	fatty acid binding protein 2	Homo sapiens	8-14
32631086-3	2020	eGFR was calculated using the CKD-EPI creatinine formula utilizing all follow-up creatinine values.	Creatinine	38-48	epidermal growth factor receptor	Homo sapiens	0-4
32631086-3	2020	eGFR was calculated using the CKD-EPI creatinine formula utilizing all follow-up creatinine values.	Creatinine	81-91	epidermal growth factor receptor	Homo sapiens	0-4
32147922-0	2020	Urinary orosomucoid 1 protein to creatinine ratio as a potential biomarker for early screening of kidney impairment in type-2 diabetes patients.	Creatinine	33-43	orosomucoid 1	Homo sapiens	8-21
32155236-9	2020	Patients with urinary L-FABP levels higher than the upper limit (8.4 mug/g creatinine) were more likely to reach the primary (30.43% vs. 9.77%; P = 0.003) and secondary end-points (56.52% vs. 16.67%; P < 0.001) than those with urinary L-FABP levels within the normal limits.	Creatinine	75-85	fatty acid binding protein 1	Homo sapiens	22-28
33042337-8	2020	The expression of ERalpha in the glomeruli of IgAN renal tissue decreased gradually (P = 0.001, P < 0.05) with the increasing severity of disease and its expression was associated with estimated glomerular filtration rate (eGFR), serum creatinine (Scr) and pathological grade (r = 0.876, -0.818 and -0.736, P < 0.05).	Creatinine	236-246	estrogen receptor 1	Homo sapiens	18-25
31741027-6	2020	The average urinary level of NGF/Cr was significantly higher in MS patients compared to other neurologic populations (8 vs. 0.56 vs. 1.25 pg/mg of creatinine; p = 0.001) as well for the average urinary level of BDNF (88.3 vs. 5 vs. 4.8 pg/mg of creatinine; p &lt; 0.0001).	Creatinine	147-157	nerve growth factor	Homo sapiens	29-32
31741027-6	2020	The average urinary level of NGF/Cr was significantly higher in MS patients compared to other neurologic populations (8 vs. 0.56 vs. 1.25 pg/mg of creatinine; p = 0.001) as well for the average urinary level of BDNF (88.3 vs. 5 vs. 4.8 pg/mg of creatinine; p &lt; 0.0001).	Creatinine	245-255	nerve growth factor	Homo sapiens	29-32
32867176-6	2020	The qualitative glomerulonephritic score was less severe and there was significantly less serum creatinine in MRL/lpr properdin-deficient mice compared to MRL/lpr properdin wildtype littermate mice.	Creatinine	96-106	Fas (TNF receptor superfamily member 6)	Mus musculus	114-117
32826075-6	2021	Renal function, represented by serum creatinine, urea nitrogen and cystatin-C, was significantly decreased in the low-eGFR group (P<0.001 for all) at the time of renal biopsy.	Creatinine	37-47	epidermal growth factor receptor	Homo sapiens	118-122
32737207-0	2020	The Estimation Formula for the Urinary Albumin-Creatinine Ratio Based on the Protein-Creatinine Ratio Are Not Valid for a Kidney Transplant and a Living Donor Cohort.	Creatinine	47-57	albumin	Homo sapiens	39-46
32737207-0	2020	The Estimation Formula for the Urinary Albumin-Creatinine Ratio Based on the Protein-Creatinine Ratio Are Not Valid for a Kidney Transplant and a Living Donor Cohort.	Creatinine	85-95	albumin	Homo sapiens	39-46
32869948-9	2020	In addition, urinary vanin-1 had a significant positive correlation with the urinary protein-to-creatinine ratio (UPCR) (r = 0.21; P = .021) and albumin-to-creatinine ratio (UACR) (r = 0.61; P < .01).	Creatinine	96-106	vanin 1	Homo sapiens	21-28
32869948-9	2020	In addition, urinary vanin-1 had a significant positive correlation with the urinary protein-to-creatinine ratio (UPCR) (r = 0.21; P = .021) and albumin-to-creatinine ratio (UACR) (r = 0.61; P < .01).	Creatinine	156-166	vanin 1	Homo sapiens	21-28
32702804-7	2020	After adjustment for age, BMI, menstrual cycle, and parity history, creatinine-adjusted BPA was significantly associated with increases in 8-isoprostane (beta = 0.74, 95% CI = 0.07, 1.41; p = 0.031) and IFN-gamma (beta = 0.18, 95% CI = 0.00, 0.36; p = 0.046).	Creatinine	68-78	interferon gamma	Homo sapiens	203-212
33824114-7	2020	CCl4 administration to the rats resulted to acute kidney injury with significantly increased Urea, Creatinine, K+ and MDA levels and decreased SOD activity (p<0.05, p<0.01 or p<0.001).	Creatinine	99-109	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
32908083-5	2020	Multivariable regression demonstrated rising odds of in-hospital death related with age (odds ratio (OR) = 1.055, p = 0.002), levels of C-reactive protein (CRP) (OR = 2.915, p < 0.001), creatinine (OR = 1.740, p = 0.023), lymphocyte count (OR = 0.999, p = 0.008), and magnesium level (OR = 0.032, p < 0.001) on admission.	Creatinine	186-196	C-reactive protein	Homo sapiens	136-154
32908083-5	2020	Multivariable regression demonstrated rising odds of in-hospital death related with age (odds ratio (OR) = 1.055, p = 0.002), levels of C-reactive protein (CRP) (OR = 2.915, p < 0.001), creatinine (OR = 1.740, p = 0.023), lymphocyte count (OR = 0.999, p = 0.008), and magnesium level (OR = 0.032, p < 0.001) on admission.	Creatinine	186-196	C-reactive protein	Homo sapiens	156-159
32870355-3	2021	RESULTS: In contrast to previous reports correlating NGF to OAB symptoms, we found that proNGF/NGF ratio in the OAB group was twice as high compared to controls (p = 0.009) with a lower NGF levels in women with OAB without statistical significance [1.36 (Q1, Q3: 0.668, 2.39) vs. 1.7 (Q1, Q3: 1.27, 3.045) pg/mg creatinine in control group, p = 0.05].	Creatinine	312-322	nerve growth factor	Homo sapiens	88-98
32870355-3	2021	RESULTS: In contrast to previous reports correlating NGF to OAB symptoms, we found that proNGF/NGF ratio in the OAB group was twice as high compared to controls (p = 0.009) with a lower NGF levels in women with OAB without statistical significance [1.36 (Q1, Q3: 0.668, 2.39) vs. 1.7 (Q1, Q3: 1.27, 3.045) pg/mg creatinine in control group, p = 0.05].	Creatinine	312-322	nerve growth factor	Homo sapiens	91-94
33163723-7	2020	Results: Urinary CD80/creatinine values were highest in MCD compared to other glomerular diseases and were increased in DN with proteinuria >2 compared to controls (control = 36 ng/g; MCD = 139 ng/g, P < 0.01; LN = 90 ng/g, P < 0.12; FSGS = 66 ng/g, P = 0.18; DN = 63, P = 0.03; MN = 69 ng/g, P = 0.33; ng/g, P = 0.07; IgA = 19 ng/g, P = 0.09; ADPKD = 42, P = 0.36; and pyuria 31, P = 0.20; GEE, median, P vs. control).	Creatinine	22-32	CD79a molecule	Homo sapiens	319-322
32713225-7	2022	In addition, AST, ALT, and creatinine values were found to be statistically significantly higher in the anti-TNF group compared to the IL inhibitor group.	Creatinine	27-37	tumor necrosis factor	Homo sapiens	109-112
32710733-11	2020	The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage.	Creatinine	197-207	interleukin 6	Homo sapiens	38-42
32710733-11	2020	The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage.	Creatinine	197-207	signal transducer and activator of transcription 3	Homo sapiens	52-57
32710733-11	2020	The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage.	Creatinine	197-207	nuclear factor kappa B subunit 1	Homo sapiens	70-79
32505416-11	2020	Copeptin levels were also correlated with HbA1c r = 0.171 (p = 0.101), BUN r = 0.244 (p = 0.007), creatinine r = 0.215 (p = 0.018), UACR r = 0.375 (p = <0.001) and GFR r = 0.215 (p = <0.019).	Creatinine	98-108	arginine vasopressin	Homo sapiens	0-8
32538218-8	2020	Our results indicated that the mouse antibody of CXCL4 treatment reduced the expression of urine creatinine and urea nitrogen in sepsis model.	Creatinine	97-107	platelet factor 4	Mus musculus	49-54
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Creatinine	365-367	cystatin C	Mus musculus	49-59
32863825-7	2020	Big ET-1 was positively correlated with NYHA class (r = 0.165, P = 0.018), serum creatinine concentration (Scr; r = 0.147, P = 0.034), high-sensitivity C-reactive protein (hs-CRP; r = 0.217, P = 0.002), Lg NT-pro BNP (r = 0.463, P < 0.001), left ventricular end diastolic diameter (LVEDD; r = 0.234, P = 0.039) and negatively correlated with left ventricular ejection fraction (LVEF; r = -0.181, P = 0.032).	Creatinine	81-91	endothelin 1	Homo sapiens	4-8
32699192-4	2020	The intensities of both intrarenal TLR7 and CD19 proteins were closely associated with kidney function (estimated glomerular filtration rate [eGFR] and serum creatinine concentration) and renal histopathology (tubular atrophy, leukocyte infiltration, tubulointerstitial fibrosis, and global glomerulosclerosis) in patients with IgAN.	Creatinine	158-168	toll like receptor 7	Homo sapiens	35-39
32728369-9	2020	Hypertension and creatinine clearance were associated with cTnI and hFABP.	Creatinine	17-27	fatty acid binding protein 3	Homo sapiens	68-73
32774701-5	2020	The serum creatinine and renal weight ratio was increased with obvious lesions and upregulated STAT3 and p-mTOR level.	Creatinine	10-20	signal transducer and activator of transcription 3	Mus musculus	95-100
32774708-4	2020	RESULTS: The results indicated that the levels of serum creatinine, blood urea nitrogen and serum iron, the renal iron content, and the kidney injury score were significantly decreased in the hepcidin group (P<0.05).	Creatinine	56-66	hepcidin antimicrobial peptide	Rattus norvegicus	192-200
32657163-4	2022	Administration of CCl4 resulted in a marked increase in hepatic (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase) and renal (blood urea nitrogen and creatinine) markers.	Creatinine	176-186	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
32765027-7	2020	In patients with DN, expression of miR-216a was significantly negatively correlated with creatinine (r=-0.4, P=0.04) and positively correlated with eGFR using creatinine (r=0.5, P=0.03).	Creatinine	89-99	microRNA 216a	Homo sapiens	35-43
32765027-7	2020	In patients with DN, expression of miR-216a was significantly negatively correlated with creatinine (r=-0.4, P=0.04) and positively correlated with eGFR using creatinine (r=0.5, P=0.03).	Creatinine	159-169	microRNA 216a	Homo sapiens	35-43
32207310-9	2020	Furthermore, a correlation was observed between insulin and homeostasis model assessment of insulin resistance levels with the NGAL/creatinine ratio in the overweight group (r = 0.515; p = 0.008, and r = 0.483; p = 0.014, respectively).	Creatinine	132-142	insulin	Homo sapiens	48-55
32207310-9	2020	Furthermore, a correlation was observed between insulin and homeostasis model assessment of insulin resistance levels with the NGAL/creatinine ratio in the overweight group (r = 0.515; p = 0.008, and r = 0.483; p = 0.014, respectively).	Creatinine	132-142	insulin	Homo sapiens	92-99
32057092-8	2020	Overall, 70 (9.0%) fulfilled the Cr AKI definition by CrP measurement.	Creatinine	33-35	C-reactive protein	Homo sapiens	54-57
32057092-10	2020	AUC (95% CI) for delta-Cr-% to predict AKI on day 2 was 0.82 (95% CI 0.78-0.86), and 0.74 (95% CI 0.69-0.80) when patients with AKI based on the CrP were excluded.	Creatinine	23-25	C-reactive protein	Homo sapiens	145-148
32857720-9	2020	RESULTS: CKD evolution in hypertensive patients followed by higher systolic and diastolic blood pressure (SBP, DBP) values increased creatinine, cystatin-C, and aldosterone serum concentrations by 28.76%, 28.41% and 29.43% (r<0.05), respectively.	Creatinine	133-143	D-box binding PAR bZIP transcription factor	Homo sapiens	111-114
32857720-10	2020	Polymorphic site of CYP11B2 (rs1799998) gene is associated with SBP and DBP increase (p<0.05), reduced GFR preferably calculated by CKDEPI-cystatin C (F=10.79-14.45; p<0.001) and elevated aldosterone content (F=55.84; p<0.001), creatinine and cystatin-S as well (F=4.16-5.08; p<0.05) mainly in the TT-genotype female carriers (p<0.001).	Creatinine	228-238	D-box binding PAR bZIP transcription factor	Homo sapiens	72-75
33024521-11	2020	eGFR based on cystatin C and based on both cystatin C and creatinine in CCA was low with significantly different from those of control (p<0.001).	Creatinine	58-68	epidermal growth factor receptor	Homo sapiens	0-4
33024521-12	2020	Although there was no difference in eGFR using three equations in control, creatinine based eGFR was high with significantly different from eGFR based on cystatin C and on both creatinine and cystatin C in CCA (P=0.000).	Creatinine	75-85	epidermal growth factor receptor	Homo sapiens	92-96
33024521-12	2020	Although there was no difference in eGFR using three equations in control, creatinine based eGFR was high with significantly different from eGFR based on cystatin C and on both creatinine and cystatin C in CCA (P=0.000).	Creatinine	75-85	epidermal growth factor receptor	Homo sapiens	92-96
32681069-3	2020	Results demonstrated that urine albumin to creatinine ratio and epithelial-to-mesenchymal transition (EMT) were increased in kidneys of ZnT8-KO-STZ and ZnT8-KO-db/db mice compared with C57BL/6 J and ZnT8-KO mice, while serum TGF-beta1, IL-6, and TNF-alpha levels were elevated in parallel.	Creatinine	43-53	solute carrier family 30 (zinc transporter), member 8	Mus musculus	136-140
32681069-3	2020	Results demonstrated that urine albumin to creatinine ratio and epithelial-to-mesenchymal transition (EMT) were increased in kidneys of ZnT8-KO-STZ and ZnT8-KO-db/db mice compared with C57BL/6 J and ZnT8-KO mice, while serum TGF-beta1, IL-6, and TNF-alpha levels were elevated in parallel.	Creatinine	43-53	solute carrier family 30 (zinc transporter), member 8	Mus musculus	152-156
32681069-3	2020	Results demonstrated that urine albumin to creatinine ratio and epithelial-to-mesenchymal transition (EMT) were increased in kidneys of ZnT8-KO-STZ and ZnT8-KO-db/db mice compared with C57BL/6 J and ZnT8-KO mice, while serum TGF-beta1, IL-6, and TNF-alpha levels were elevated in parallel.	Creatinine	43-53	solute carrier family 30 (zinc transporter), member 8	Mus musculus	152-156
32677951-9	2020	The urine klotho-to-creatinine ratio (UrKl/Cr) was significantly lower in stage 3 dogs than the control group and was significantly lower in dogs with stage 3 and 4 CKD than in those with stage 1 and 2 disease.	Creatinine	20-30	klotho	Canis lupus familiaris	10-16
32661220-15	2020	When CRP apheresis was restarted, CRP levels and creatinine kinases (CK/CK-MB) declined again.	Creatinine	49-59	C-reactive protein	Homo sapiens	5-8
32468592-7	2020	Transcript levels of MMP7 (P = .05) and TIMP1 (P = .005) were positively associated with serum creatinine in cats with CKD, but not in control cats.	Creatinine	95-105	TIMP metallopeptidase inhibitor 1	Felis catus	40-45
32684830-11	2020	Also, there was a significant positive correlation between serum levels of TNF-alpha with FBG (fasting blood glucose), creatinine, total cholesterol, LDL-C, HbA1c, and microalbumin/creatinine ratio (ACR) among the DN group (p = 0.042, <0.001, <0.001, <0.001, 0.027, and 0.043, respectively).	Creatinine	119-129	tumor necrosis factor	Homo sapiens	75-84
32684830-11	2020	Also, there was a significant positive correlation between serum levels of TNF-alpha with FBG (fasting blood glucose), creatinine, total cholesterol, LDL-C, HbA1c, and microalbumin/creatinine ratio (ACR) among the DN group (p = 0.042, <0.001, <0.001, <0.001, 0.027, and 0.043, respectively).	Creatinine	181-191	tumor necrosis factor	Homo sapiens	75-84
32286129-5	2020	Patients with a higher ratio of C5a to C5 had higher neutrophil percentage and serum immunoglobulin G levels, and significantly lower creatinine levels.	Creatinine	134-144	complement C5a receptor 1	Homo sapiens	32-35
32583487-5	2020	Analyzing sepsis-induced AKI rats and the cell model, our results revealed that miR-152-3p was upregulated in septic AKI patients and positively correlated with serum creatinine, urea nitrogen, interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha).	Creatinine	167-177	microRNA 152	Rattus norvegicus	80-87
32508065-2	2020	Urinary angiotensinogen to creatinine ratio (AGT/Cr) was suggested as a novel biomarker to reflect intrarenal RAS activity.	Creatinine	27-37	angiotensinogen	Homo sapiens	8-23
32508065-2	2020	Urinary angiotensinogen to creatinine ratio (AGT/Cr) was suggested as a novel biomarker to reflect intrarenal RAS activity.	Creatinine	27-37	angiotensinogen	Homo sapiens	45-48
32695298-7	2020	Urine volume and creatinine excretion were significantly modulated by insulin and oral INP in diabetic groups (P-value<0.05), although the effects of INP on the modulation of execration of urea, acid uric, and albumin was more dramatic.	Creatinine	17-27	insulin	Homo sapiens	70-77
32481361-8	2020	Besides, MiR-146a and miR-146b expressions were positively correlated with acute pathologic and chronic health evaluation II score, sequential organ failure assessment score, serum creatinine, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-17, while negatively correlated with albumin.	Creatinine	181-191	microRNA 146b	Homo sapiens	22-30
31841263-14	2020	The AUC of urinary CXCL-9/creatinine ratios comparatively reached 0.79.	Creatinine	26-36	C-X-C motif chemokine ligand 9	Homo sapiens	19-25
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	136-146	microRNA 20a	Homo sapiens	16-23
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	136-146	microRNA 195	Homo sapiens	42-49
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	159-169	microRNA 20a	Homo sapiens	16-23
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	159-169	microRNA 195	Homo sapiens	42-49
32078076-8	2020	This retrospective study of MPO-AAV patients in a single Chinese center suggests that treatment resistance was positively associated with lung involvement and the initial serum creatinine level and was negatively associated with platelet and serum C3 levels.	Creatinine	177-187	myeloperoxidase	Homo sapiens	28-31
32268368-6	2020	Among participants without diabetes, there were also significant associations of NT-proBNP (OR, 1.40 [95% CI, 1.08-1.81]) and urine albumin-to-creatinine ratio (OR, 1.55 [95% CI, 1.22-1.97]) with PN.	Creatinine	143-153	albumin	Homo sapiens	132-139
31908003-5	2020	For clinical parameters, miR-146b was positively correlated with serum creatinine (P = .047), beta-2-microglobulin (P &lt; .001), lactate dehydrogenase (P &lt; .001), bone lesion (P = .027), International Staging System (ISS) stage (P &lt; .001), and t (4; 14; P = .006), while negatively correlated with albumin (P = .004) in MM patients.	Creatinine	71-81	microRNA 146b	Homo sapiens	25-33
31769936-0	2020	Insulin resistance is associated with urinary albumin-creatinine ratio in normal weight individuals with hypertension and diabetes: the REACTION study.	Creatinine	54-64	insulin	Homo sapiens	0-7
31957090-6	2020	RESULTS: After initiating ACTH treatment, urinary calcium (Ca)/creatinine ratio and urinary pH increased within 2 weeks.	Creatinine	63-73	proopiomelanocortin	Homo sapiens	26-30
32170349-0	2020	Correction to: Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA.	Creatinine	176-186	epidermal growth factor receptor	Homo sapiens	188-192
32107682-10	2020	CONCLUSIONS: Levels of urinary I-FABP and urinary I-FABP/creatinine were significantly elevated in patients with confirmed AL following colorectal surgery, suggesting their potential as a non-invasive biomarker for colorectal anastomotic leakage.	Creatinine	57-67	fatty acid binding protein 2	Homo sapiens	50-56
32349632-6	2021	MDA, serum TNF-alpha, AST, ALT, urea, and creatinine levels (p < 0.05) were significantly higher, and SOD activity and GSH level were significantly (p < 0.05) lower in the CCl4 group than in the control group.	Creatinine	42-52	C-C motif chemokine ligand 4	Rattus norvegicus	172-176
32349632-7	2021	Treatment with chrysin in the chrysin + CCl4 group decreased MDA, AST, ALT, creatinine, and TNF-alpha levels (p < 0.05), and increased SOD activity, GSH levels (p < 0.05), and serum TNF-alpha levels (p < 0.05).	Creatinine	76-86	C-C motif chemokine ligand 4	Rattus norvegicus	40-44
33543033-10	2020	Renal function as measured by the urinary albumin/creatinine ratio was improved in the mice with knockdown of CRT as compared to diabetic mice injected with saline or subjected to ultrasound and injected with control GFP plasmid.	Creatinine	50-60	calreticulin	Mus musculus	110-113
32186370-0	2020	Paper-Based Device for Naked Eye Urinary Albumin-Creatinine Ratio Evaluation.	Creatinine	49-59	albumin	Homo sapiens	41-48
32293409-7	2020	Postoperative exogenous ALB infusion positively correlated with blood urea nitrogen, creatinine, complication grade, postoperative intraperitoneal hemorrhage and pancreatic fistula.	Creatinine	85-95	albumin	Homo sapiens	24-27
32296091-6	2020	There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC).	Creatinine	149-159	interleukin 6	Homo sapiens	84-88
32296091-6	2020	There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC).	Creatinine	222-232	interleukin 6	Homo sapiens	84-88
32296091-10	2020	Dialysis effluent IL-6 and COX-2 levels correlate with the concomitant D/P4 and MTAC of creatinine.	Creatinine	88-98	interleukin 6	Homo sapiens	18-22
32260098-6	2020	AhR-/- females survived and developed a less severe renal insufficiency that WT mice, reflected by urea, creatinine, and IS measurement in serum.	Creatinine	105-115	aryl-hydrocarbon receptor	Mus musculus	0-3
31489594-8	2020	eGFR was calculated using the creatinine-based formula.	Creatinine	30-40	epidermal growth factor receptor	Homo sapiens	0-4
31732838-13	2020	Renal manifestations (proteinuria and decreased creatinine in urine) were successfully mitigated by RP-1 and Res-2 and high dose combination of resveratrol and piperine.	Creatinine	48-58	retinitis pigmentosa 1 (human)	Mus musculus	100-114
32094096-6	2020	In parallel, ABCB1 variant allele carriers had higher creatinine in combination therapy with a median creatinine (mg/dL) of 0.74 vs. 0.56 for variant allele carriers vs. reference; P = 0.003.	Creatinine	54-64	ATP binding cassette subfamily B member 1	Homo sapiens	13-18
32094096-6	2020	In parallel, ABCB1 variant allele carriers had higher creatinine in combination therapy with a median creatinine (mg/dL) of 0.74 vs. 0.56 for variant allele carriers vs. reference; P = 0.003.	Creatinine	102-112	ATP binding cassette subfamily B member 1	Homo sapiens	13-18
31954161-3	2020	We showed that CYP2J2 significantly decreased I/R-induced upregulation of blood urea nitrogen and serum creatinine and enhanced autophagy during I/R treatment.	Creatinine	104-114	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	15-21
32131418-6	2020	An increased urinary level of Cd to the median level of 0.38 mug/L (0.44 mug/g of creatinine) was associated with a decrease in the eGFR by 4.94 mL/min/1.73 m2 (p = 0.011).	Creatinine	82-92	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
32332681-4	2020	In the correlation analysis, serum UA/Cr showed a significantly positive correlation with age, hypertension, systolic pressure (SBP), diastolic pressure (DBP), Waist, body mass index (BMI), TG, UA and negative correlation with type 2 diabetes mellitus (T2DM) and Cr (P all < .001).	Creatinine	38-40	D-box binding PAR bZIP transcription factor	Homo sapiens	154-157
31125398-6	2020	Individuals in the CNS-IMP cluster were the oldest, with the worst function and more likely to live in a nursing home; those in the HEART cluster had the highest number of co-occurring diseases and drugs, and they exhibited the highest mean values of serum creatinine and C-reactive protein.	Creatinine	257-267	C-reactive protein	Homo sapiens	272-290
32221363-8	2020	Serum adiponectin level was inversely associated with eGFR (p < 0.001) and positively correlated with urine albumin-creatinine ratio.	Creatinine	116-126	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
32044349-9	2020	Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05).	Creatinine	234-244	albumin	Homo sapiens	157-160
31554598-7	2020	RESULTS: Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12).	Creatinine	102-112	TIMP metallopeptidase inhibitor 1	Homo sapiens	24-30
32044349-9	2020	Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05).	Creatinine	246-248	albumin	Homo sapiens	157-160
31688312-9	2020	The random effect model analysis revealed a mean reduction of 2.63 ng/ml/h (95% CI: -4.46 to -0.8; P = 0.005) in plasma renin activity (PRA), mean reduction of 255.37 pg/ml (95% CI: -441.23 to -69.5; P = 0.007) in plasma aldosterone levels, and a mean increase of 0.14 mg/dl (95% CI: -0.13 to 0.41; P = 0.32) in serum creatinine levels favouring add-on alpha agonist group.	Creatinine	318-328	renin	Homo sapiens	120-125
32024663-0	2020	Estimating Urine Albumin-to-Creatinine Ratio from Protein-to-Creatinine Ratio: Development of Equations using Same-Day Measurements.	Creatinine	28-38	albumin	Homo sapiens	17-24
32008434-5	2020	In contrast, urine albumin adjusted for creatinine showed significant positive associations with atrial fibrillation, coronary artery disease, heart failure, hemorrhagic stroke, lipid-lowering medication, and T2D.	Creatinine	40-50	albumin	Homo sapiens	19-26
32008434-7	2020	After correcting for potential horizontal pleiotropy, we found evidence of causal associations of UNa/UK and albumin with BP (beta systolic BP >=2.63; beta diastolic BP >=0.85 SD increase in BP per SD change in UNa/UK and urine albumin adjusted for creatinine; P<=0.04), and of albumin with T2D (odds ratio=1.33 per SD change in albumin, P=0.02).	Creatinine	249-259	albumin	Homo sapiens	109-116
32024663-1	2020	BACKGROUND: Urine albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) are used to measure urine protein.	Creatinine	29-39	albumin	Homo sapiens	18-25
32097414-4	2020	RESULTS: eGFR was consistently lower when creatinine-based rather than cystatin C-based estimating equations were used.	Creatinine	42-52	epidermal growth factor receptor	Homo sapiens	9-13
32728357-14	2020	A significant correlation was found between the level of CRP and haemoglobin (r = -0.3; p < 0.0001), red cell distribution width (r = 0.22; p < 0.0001), ejection fraction (r = -0.24, p = 0.007), troponin T (r = 0.3; p < 0.0001), creatinine (r = 0.26; p = 0.001) and body mass index (r = -0.29; p = 0.005).	Creatinine	229-239	C-reactive protein	Homo sapiens	57-60
32097414-5	2020	eGFR was lower when creatinine-based or cystatin C-based equations were indexed to 1.73m2 BSA than when they were indexed to actual BSA.	Creatinine	20-30	epidermal growth factor receptor	Homo sapiens	0-4
32097414-8	2020	CONCLUSIONS: With severe obesity, high fat-free mass and BSA result in low estimates of eGFR indexed to 1.73m2 BSA, especially when creatinine-based estimating equations are used.	Creatinine	132-142	epidermal growth factor receptor	Homo sapiens	88-92
31974286-5	2020	The primary outcome was change in urinary TGF-beta1-to-creatinine from baseline to months 3 and 6.	Creatinine	55-65	transforming growth factor beta 1	Homo sapiens	42-51
32226931-9	2020	Treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in serum creatinine (SCr) compared with ACE inhibitors or ARBs alone (MD: -9.87; 95% CI: -13.76, -5.97).	Creatinine	101-111	angiotensin I converting enzyme	Homo sapiens	15-18
31843715-9	2020	SAP-drug (anti-TNF-alpha/HGF in SAP hydrogel) treatment reduced the level of serum creatinine (Scr), blood urea nitrogen (BUN), tubular apoptosis, renal inflammatory factors, and macrophage infiltration compared to Free-drug (anti-TNF-alpha/HGF in solution) or SAP alone.	Creatinine	83-93	tumor necrosis factor	Mus musculus	15-24
31843715-9	2020	SAP-drug (anti-TNF-alpha/HGF in SAP hydrogel) treatment reduced the level of serum creatinine (Scr), blood urea nitrogen (BUN), tubular apoptosis, renal inflammatory factors, and macrophage infiltration compared to Free-drug (anti-TNF-alpha/HGF in solution) or SAP alone.	Creatinine	83-93	SH2 domain containing 1A	Mus musculus	0-3
31843715-9	2020	SAP-drug (anti-TNF-alpha/HGF in SAP hydrogel) treatment reduced the level of serum creatinine (Scr), blood urea nitrogen (BUN), tubular apoptosis, renal inflammatory factors, and macrophage infiltration compared to Free-drug (anti-TNF-alpha/HGF in solution) or SAP alone.	Creatinine	83-93	SH2 domain containing 1A	Mus musculus	32-35
32050627-11	2020	Thus, urinary L-FABP levels on admission are potent and independent predictors of long-term adverse outcomes, and they might improve the long-term risk stratification of patients admitted at medical CICUs, when used in combination with creatinine-defined AKI.	Creatinine	236-246	fatty acid binding protein 1	Homo sapiens	14-20
31564018-6	2020	Concomitant amiodarone, an antiarrhythmic agent and moderate CYP3A/ABCB1 inhibitor, the impaired-function variant ABCG2 c.421C > A, and sex predicted higher apixaban concentrations when controlling for age, weight and serum creatinine (multivariate regression; R2 = 0.34).	Creatinine	224-234	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	114-119
32095231-8	2020	Total bilirubin and creatinine clearance were the most predictive covariates for apparent riociguat metabolic clearance to M1 (CLf,M1/F) and for apparent riociguat clearance through remaining pathways (CLe,r/F), respectively.	Creatinine	20-30	myoregulin	Homo sapiens	123-125
31857443-3	2020	Important changes include: 1) the decision to treat high-risk individuals with a glucagon-like peptide 1 (GLP-1) receptor agonist or sodium-glucose cotransporter 2 (SGLT2) inhibitor to reduce major adverse cardiovascular events (MACE), hospitalization for heart failure (hHF), cardiovascular death, or chronic kidney disease (CKD) progression should be considered independently of baseline HbA1c or individualized HbA1c target; 2) GLP-1 receptor agonists can also be considered in patients with type 2 diabetes without established cardiovascular disease (CVD) but with the presence of specific indicators of high risk; and 3) SGLT2 inhibitors are recommended in patients with type 2 diabetes and heart failure, particularly those with heart failure with reduced ejection fraction, to reduce hHF, MACE, and CVD death, as well as in patients with type 2 diabetes with CKD (estimated glomerular filtration rate 30 to <=60 mL min-1 [1.73 m]-2 or urinary albumin-to-creatinine ratio >30 mg/g, particularly >300 mg/g) to prevent the progression of CKD, hHF, MACE, and cardiovascular death.	Creatinine	961-971	glucagon	Homo sapiens	81-104
31568610-7	2020	According to receiver operating characteristic (ROC) analysis, combining NAG and creatinine showed a significantly increased area under the curve (AUC) compared to creatinine alone (AUC: 0.75 vs 0.87; P < .001).	Creatinine	164-174	N-acetyl-alpha-glucosaminidase	Homo sapiens	73-76
31557362-8	2020	Logistic regression analysis revealed that initial serum sodium concentration (odds ratio, 95% confidence interval: 18.475, 3.967-86.035; P = .000) was a risk factor for reduced serum concentration, and that albumin level (1.105, 1.012-1.207; P = .026), serum creatinine level (0.975, 0.952-0.997; P = .028) and hyponatremia duration (1.297, 1.064-1.583; P = .010) were risk factors of severe hyponatremia.	Creatinine	260-270	albumin	Homo sapiens	208-215
31557362-11	2020	The initial albumin level is a risk factor for severe hyponatremia as is serum creatinine, although the latter is negatively correlated with the occurrence of the condition.	Creatinine	79-89	albumin	Homo sapiens	12-19
31568610-11	2020	NAG presented as an independent AKI predictor beside creatinine, age, the diagnosis of myocardial infarction and mean arterial pressure.	Creatinine	53-63	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-3
31792084-1	2020	OBJECTIVE: To describe discrepancies in calculated and measured glomerular filtration rate in patients using PARP (poly ADP ribose polymerase) inhibitors who had an elevation in serum creatinine levels.	Creatinine	184-194	poly(ADP-ribose) polymerase 1	Homo sapiens	109-113
32038102-9	2020	Age- and sex-adjusted analysis of FABP1 showed positive associations with body mass index (BMI), waist circumference, homeostasis model assessment estimate of beta-cell function, creatinine, and fatty liver index, but showed negative associations with albumin and estimated glomerular filtration rate (eGFR).	Creatinine	179-189	fatty acid binding protein 1	Homo sapiens	34-39
31936687-10	2020	After adjustment for patients" age, body mass index, white blood cell count, the requirement of antibiotics during hospitalization, diabetes, RDW, and peak creatinine, serum albumin was independently associated with massive APE (OR 0.234, 95% CI 0.129-0.4242, P < 0.001).	Creatinine	156-166	albumin	Homo sapiens	174-181
32933312-4	2020	Both EASM and Tan-IIA significantly decreased serum uric acid (SUA), serum creatinine (SCR), urine uric acid (UUA), and increased urine creatinine (UCR), and blood urea nitrogen (BUN) levels in experimental UAN mice.	Creatinine	75-85	ATPase, class II, type 9A	Mus musculus	18-21
32933312-4	2020	Both EASM and Tan-IIA significantly decreased serum uric acid (SUA), serum creatinine (SCR), urine uric acid (UUA), and increased urine creatinine (UCR), and blood urea nitrogen (BUN) levels in experimental UAN mice.	Creatinine	136-146	ATPase, class II, type 9A	Mus musculus	18-21
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 9	Homo sapiens	129-132
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 9	Homo sapiens	133-138
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	145-150
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	tumor necrosis factor	Homo sapiens	152-155
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	interleukin 6	Homo sapiens	168-172
31800161-5	2020	Decreased levels of renal KLF4 were positively correlated with dietary-induced renal dysfunction, including increased levels of creatinine and blood urea nitrogen.	Creatinine	128-138	Kruppel-like factor 4 (gut)	Mus musculus	26-30
31800161-9	2020	In clinical renal biopsies and plasma, the renal Klf4 level was negatively associated with circulating levels of creatinine but positively associated with renal creatinine clearance.	Creatinine	113-123	Kruppel-like factor 4 (gut)	Mus musculus	49-53
31800161-9	2020	In clinical renal biopsies and plasma, the renal Klf4 level was negatively associated with circulating levels of creatinine but positively associated with renal creatinine clearance.	Creatinine	161-171	Kruppel-like factor 4 (gut)	Mus musculus	49-53
31448496-9	2020	RESULTS: Cystatin C and BTP showed excellent correlations with creatinine values at baseline and follow-up.	Creatinine	63-73	prostaglandin D2 synthase	Homo sapiens	24-27
31956139-8	2020	Age- and sex-adjusted ADPN levels were positively associated with heart rate, QTc interval, left ventricular mass index, and creatinine but negatively associated with left ventricular ejection fraction, waist circumference, current smoking, total cholesterol, triglycerides, low-density lipoprotein cholesterol, albumin, and estimated glomerular filtration rate.	Creatinine	125-135	adiponectin, C1Q and collagen domain containing	Homo sapiens	22-26
32076606-1	2020	Several studies show that even a level of urine albumin/creatinine ratio (UACR) within the normal range (below 30 mg/g) increases the risk of cardiovascular diseases.	Creatinine	56-66	albumin	Homo sapiens	48-55
33083794-8	2020	Moreover, the low Pearson correlations (r- values) between ALP level with age (r=0.179), gender, body mass index (r=0.236), creatinine (r=0.044) or estimated glomerular filtration rate (r=0.048) suggest that ALP may be an independent biomarker which is relatively unaffected by other individual-level variables.	Creatinine	124-134	alkaline phosphatase, placental	Homo sapiens	59-62
31303349-12	2020	LIMITATIONS: Creatinine results were not blinded, making it possible that ACE-inhibitor/placebo dosing was influenced by creatinine level.	Creatinine	13-23	angiotensin I converting enzyme	Homo sapiens	74-77
31303349-12	2020	LIMITATIONS: Creatinine results were not blinded, making it possible that ACE-inhibitor/placebo dosing was influenced by creatinine level.	Creatinine	121-131	angiotensin I converting enzyme	Homo sapiens	74-77
31606352-6	2020	In this respect, calculators (or formulas) for the estimation of Glomerular Filtration Rate (eGFR) and Albumin to Creatinine Ratio (ACR) are simple, practical and easily available methods for this purpose.	Creatinine	114-124	albumin	Homo sapiens	103-110
31671464-9	2020	RESULTS: Elevated serum creatinine and BUN, hypokalemia, and hypophosphatemia, in addition, to an increase in urine glucose, protein, gamma-GT, and alkaline phosphatase (ALP), were evident in IFO-treated animals.	Creatinine	24-34	alkaline phosphatase, placental	Homo sapiens	148-168
31671464-9	2020	RESULTS: Elevated serum creatinine and BUN, hypokalemia, and hypophosphatemia, in addition, to an increase in urine glucose, protein, gamma-GT, and alkaline phosphatase (ALP), were evident in IFO-treated animals.	Creatinine	24-34	alkaline phosphatase, placental	Homo sapiens	170-173
33378070-3	2020	With regard to daily medical practice, the only existing prognostic biomarkers in DKD remain urine albumin-creatinine ratio based on the urinary assessment of albumin and creatinine, and estimated glomerular filtration rate - on the basis of serum creatinine concentration.	Creatinine	107-117	albumin	Homo sapiens	99-106
33378070-3	2020	With regard to daily medical practice, the only existing prognostic biomarkers in DKD remain urine albumin-creatinine ratio based on the urinary assessment of albumin and creatinine, and estimated glomerular filtration rate - on the basis of serum creatinine concentration.	Creatinine	107-117	albumin	Homo sapiens	159-166
33378070-3	2020	With regard to daily medical practice, the only existing prognostic biomarkers in DKD remain urine albumin-creatinine ratio based on the urinary assessment of albumin and creatinine, and estimated glomerular filtration rate - on the basis of serum creatinine concentration.	Creatinine	171-181	albumin	Homo sapiens	99-106
33378070-3	2020	With regard to daily medical practice, the only existing prognostic biomarkers in DKD remain urine albumin-creatinine ratio based on the urinary assessment of albumin and creatinine, and estimated glomerular filtration rate - on the basis of serum creatinine concentration.	Creatinine	171-181	albumin	Homo sapiens	99-106
31901345-0	2020	Variation in serum creatinine methodology and eGFR equations confound longitudinal eGFR data.	Creatinine	19-29	epidermal growth factor receptor	Homo sapiens	83-87
31918915-11	2020	ALX/FPR2 dysfunction magnified obesogenic cardiomyopathy and renal inflammation ( NGAL,  TNF-alpha,  CCL2,  IL-1beta) with elevated plasma creatinine levels in aging mice.	Creatinine	139-149	formyl peptide receptor 3	Mus musculus	0-3
31915360-9	2020	eGFR was also significantly associated with CKD stages (p=0.001), serum creatinine (p=0.001), BMI (r = -0.330, p=0.005), and negatively associated with age group, duration of hypertension, smoking.	Creatinine	72-82	epidermal growth factor receptor	Homo sapiens	0-4
31792084-1	2020	OBJECTIVE: To describe discrepancies in calculated and measured glomerular filtration rate in patients using PARP (poly ADP ribose polymerase) inhibitors who had an elevation in serum creatinine levels.	Creatinine	184-194	poly(ADP-ribose) polymerase 1	Homo sapiens	115-141
31792084-12	2020	CONCLUSIONS: Serum creatinine elevation in patients taking PARP inhibitors may not be associated with a true decrease in glomerular filtration rate.	Creatinine	19-29	poly(ADP-ribose) polymerase 1	Homo sapiens	59-63
31792084-13	2020	A high index of suspicion should be maintained for alternative causes of elevated serum creatinine in patients treated with PARP inhibitors who lack other sources of renal injury.	Creatinine	88-98	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
32961538-0	2020	Creatinine at Birth Correlates with Gestational Age and Birth Weight: Another Factor of the Imbroglio in Early Neonatal Life.	Creatinine	0-10	renin binding protein	Homo sapiens	48-51
31843209-7	2020	eGFR by MDRD and the 2009 CKD-EPI equation correlated better with 51Cr-EDTA than CKD-EPI with creatinine and/or cystatin C.	Creatinine	94-104	epidermal growth factor receptor	Homo sapiens	0-4
32129207-11	2020	When we correlated the NPHS2 mutation status with disease progression, there was a statistically significant increase in serum creatinine, proteinuria, and serum albumin values in patients with NPHS2 gene mutations compared to the group without mutation (P <0.05).	Creatinine	127-137	NPHS2 stomatin family member, podocin	Homo sapiens	23-28
31949468-9	2019	The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde.	Creatinine	309-319	C-C motif chemokine ligand 4	Rattus norvegicus	17-21
31857626-4	2019	In an angiotensin II (Ang II)-induced renal injury mouse model, we found that blocking AT1R and AT2R effectively mitigates Ang II-induced increases in necroptotic tubular epithelial cell percentages, necroptosis-related RIP3 and MLKL protein expression, serum creatinine and blood urea nitrogen levels, and tubular damage scores.	Creatinine	260-270	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-28
31857626-4	2019	In an angiotensin II (Ang II)-induced renal injury mouse model, we found that blocking AT1R and AT2R effectively mitigates Ang II-induced increases in necroptotic tubular epithelial cell percentages, necroptosis-related RIP3 and MLKL protein expression, serum creatinine and blood urea nitrogen levels, and tubular damage scores.	Creatinine	260-270	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	123-129
31791262-6	2019	Compared with negative group, patients in the serum PLA2R antibody -positive group had lower serum albumin [SMD = -1.11, 95% CI (- 1.82, - 0.40), P &lt; 0.00001], higher age [MD = 2.71, 95% CI (1.94, 3.48), P &lt; 0.00001], and lower estimated glomerular filtration rate (eGFR) [MD = -10.34, 95% CI (- 12.09, - 8.60), P &lt; 0.00001]; no significant between-group difference was observed with respect to 24-h urine protein and serum creatinine.	Creatinine	433-443	albumin	Homo sapiens	99-106
31861139-9	2019	Moreover, ACE2 activity was recovered in harvested kidneys from ACE2-deficient mice infused with 1-619, but not in controls (23.1 +- 4.3 RFU/microg creatinine/h and 1.96 +- 0.73 RFU/microg protein/hr, respectively).	Creatinine	148-158	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	10-14
31764746-8	2019	However, median [interquartile range] urinary PlGF/creatinine concentrations (pg/mg) measured at mid-pregnancy (22-26 weeks of gestation) were significantly lower among women who developed composite adverse outcome at less than 34 weeks of gestation (42.7 [32.4-80.8] vs 255.6 [118.7-391.8] P&lt;.001) and significantly lower among women who developed preeclampsia at less than 34 weeks of gestation (42.7 [27.5-80.7] vs 244.6 [112.9-390.6] P&lt;.001).	Creatinine	51-61	placental growth factor	Homo sapiens	46-50
31819578-2	2019	Urinary C-peptide creatinine ratio (UCPCR) represents a non-invasive and practical method for assessing endogenous insulin production to facilitate diabetes classification.	Creatinine	18-28	insulin	Homo sapiens	115-122
31601454-9	2019	However, after LPS, Xbp1 knockdown mice displayed lower renal NGAL, pro-apoptotic factor CHOP, serum creatinine levels, and a tendency towards lower Tlr4 compared to LPS-treated mice with intact Xbp1s.	Creatinine	101-111	X-box binding protein 1	Mus musculus	20-24
31890681-9	2019	Results: Descriptive analysis of the data demonstrates a slight increase in the serum creatinine measured by Jaffe assay which leads to a substantial decrease in the levels of eGFR compared to the eGFR calculated by the enzymatic assay.	Creatinine	86-96	epidermal growth factor receptor	Homo sapiens	176-180
31890681-9	2019	Results: Descriptive analysis of the data demonstrates a slight increase in the serum creatinine measured by Jaffe assay which leads to a substantial decrease in the levels of eGFR compared to the eGFR calculated by the enzymatic assay.	Creatinine	86-96	epidermal growth factor receptor	Homo sapiens	197-201
31215071-6	2019	Multivariable analyses showed that renal function and PTH were significant predictors of calciuria and urinary calcium/creatinine, whilst 25D remained a predictor only of urinary calcium/creatinine ratio.	Creatinine	119-129	parathyroid hormone	Homo sapiens	54-57
31659787-6	2019	The main study outcome was an eGFR less than 60 mL/min * 1.73 m2 based on the creatinine nadir during the first year following diagnosis.	Creatinine	78-88	epidermal growth factor receptor	Homo sapiens	30-34
31684160-10	2019	The muscle RING-finger protein-1 expression was decreased in tibialis and urinary 3-methyl-histidine to creatinine ratio slightly lower with the supply of NCP.	Creatinine	104-114	tripartite motif containing 63	Rattus norvegicus	4-32
31799876-6	2019	Blood urea nitrogen (BUN) and creatinine were higher in UCP2-/-+IR mouse serum than in IR mouse serum.	Creatinine	30-40	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	56-60
31717603-9	2019	In a subgroup, the increase in serum SLPI was evident before AKI was diagnosed on the basis of serum creatinine or urine output (24 h, VC: OR = 4.89 (1.54-19.92)).	Creatinine	101-111	secretory leukocyte peptidase inhibitor	Homo sapiens	37-41
31511257-12	2019	N1-methyladenosine (m1A) was found as the novel substrate of renal cationic drug transporters, OCT2 and MATE2-K. m1A was revealed to have some advantages compared to other OCT2/MATEs substrate, creatinine and N1-methylnicotinamide.	Creatinine	194-204	POU domain, class 2, transcription factor 2	Mus musculus	95-99
31511257-12	2019	N1-methyladenosine (m1A) was found as the novel substrate of renal cationic drug transporters, OCT2 and MATE2-K. m1A was revealed to have some advantages compared to other OCT2/MATEs substrate, creatinine and N1-methylnicotinamide.	Creatinine	194-204	POU domain, class 2, transcription factor 2	Mus musculus	172-176
31557418-9	2019	As the serum creatinine, serum BUN levels increased, the expression of HMGB2 decreased; Besides, the HMGB2 expression was positively correlated with serum complement 3(C3) levels, and it also had a negative correlation with the diastolic blood pressure, but not reach statistical significance.	Creatinine	13-23	high mobility group box 2	Homo sapiens	71-76
31321875-4	2019	The primary endpoint was the evolution of the serum creatinine-based estimated glomerular filtration rate (eGFR-scr).	Creatinine	52-62	epidermal growth factor receptor	Homo sapiens	107-111
31557418-9	2019	As the serum creatinine, serum BUN levels increased, the expression of HMGB2 decreased; Besides, the HMGB2 expression was positively correlated with serum complement 3(C3) levels, and it also had a negative correlation with the diastolic blood pressure, but not reach statistical significance.	Creatinine	13-23	high mobility group box 2	Homo sapiens	101-106
31660882-8	2019	A cut-off value for optimal sensitivity and specificity of salivary creatinine to diagnose CKD with glomerular filtration rate (GFR) &lt; 60 mL/min/1.73 m2 was obtained.	Creatinine	68-78	CD59 molecule (CD59 blood group)	Homo sapiens	144-149
31321875-10	2019	CONCLUSIONS: Similar eGFR-scr decreases were observed in patients using different antiretroviral drugs inhibiting the tubular transport of creatinine, separately or in combination, with no alterations in proteinuria or cystatin C-based eGFR.	Creatinine	139-149	epidermal growth factor receptor	Homo sapiens	21-25
31073091-2	2019	Aspartate aminotransferase (AST), commonly ordered with alanine aminotransferase (ALT) and blood urea nitrogen (BUN), commonly ordered with creatinine (Cr), often add little value to patient management at significant cost.	Creatinine	140-150	solute carrier family 17 member 5	Homo sapiens	0-26
31482669-8	2019	Higher VWF levels were observed among RTx with creatinine &gt;=1.4mg/dL compared to other RTx, P=0.01.	Creatinine	47-57	von Willebrand factor	Homo sapiens	7-10
31773054-5	2019	In children with s-creatinine increase, IL-6 values were significantly different between AR and cAMR.	Creatinine	19-29	interleukin 6	Homo sapiens	40-44
30560432-0	2019	Cystatin C and creatinine-based eGFR levels and their correlation to long-term morbidity and mortality in older adults.	Creatinine	15-25	epidermal growth factor receptor	Homo sapiens	32-36
31073091-2	2019	Aspartate aminotransferase (AST), commonly ordered with alanine aminotransferase (ALT) and blood urea nitrogen (BUN), commonly ordered with creatinine (Cr), often add little value to patient management at significant cost.	Creatinine	152-154	solute carrier family 17 member 5	Homo sapiens	28-31
31268920-9	2019	RESULTS: A positive association between MLXIPL and UA level was observed in the total sample of women after control for confounding covariates, including FM, TGs, and creatinine (P = 0.027).	Creatinine	167-177	MLX interacting protein like	Homo sapiens	40-46
31250147-12	2019	Fetuin-A levels positively correlated with serum creatinine (r 0.326, p = 0.014), and negatively correlated with estimated glomerular filtration rate (r - 0.297, p = 0.026).	Creatinine	49-59	alpha 2-HS glycoprotein	Homo sapiens	0-8
31370677-9	2019	SIRP-alphamut mice were protected from renal IR compared with WT animals, demonstrating improved serum creatinine, less histologic damage, reduced proinflammatory cytokine production, and diminished production of reactive oxygen species (ROS).	Creatinine	103-113	signal-regulatory protein alpha	Mus musculus	0-4
31530601-13	2019	CONCLUSIONS: Cystatin C and creatinine derived eGFR are powerful and independent predictors of long-term mortality following cardiac surgery.	Creatinine	28-38	epidermal growth factor receptor	Homo sapiens	47-51
31146836-8	2019	Under the optimum condition, the linear range of urea and creatinine were 30-240 mg L-1 and 10-500 mg L-1, with limits of detection of 9.0 mg L-1 and 0.9 mg L-1, respectively.	Creatinine	58-68	L1 cell adhesion molecule	Homo sapiens	84-105
31409673-6	2019	However, mice carrying both Adamts13-/-  and cfhW/R  exhibit thrombocytopenia, low plasma haptoglobin, increased fragmentation of erythrocytes in peripheral blood smear, increased plasma levels of lactate dehydrogenase activity, BUN, and creatinine, as well as an increased mortality rate, consistent with the development of thrombotic microangiopathy.	Creatinine	238-248	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	28-36
31719297-8	2019	ACE inhibitors protected carriers of alleles that supposedly decrease serum ACE levels (rs1800764-T, rs4291-A, Alu II) regarding creatinine clearance variations (P <0.005), but carriers of Alu DD (P <0.02), rs1800764-C (P <0.05), or rs4291-AT (P <0.04) showed better blood pressure lowering effects.	Creatinine	129-139	angiotensin I converting enzyme	Homo sapiens	0-3
31339777-5	2019	ANG II induced similar elevations of systolic blood pressure in Trpa1-/- and wild-type (WT) mice but led to higher levels of blood urea nitrogen (P < 0.05), serum creatinine (P < 0.05), and renal fibrosis (P < 0.01) in Trpa1-/- mice than WT mice.	Creatinine	163-173	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
31719297-8	2019	ACE inhibitors protected carriers of alleles that supposedly decrease serum ACE levels (rs1800764-T, rs4291-A, Alu II) regarding creatinine clearance variations (P <0.005), but carriers of Alu DD (P <0.02), rs1800764-C (P <0.05), or rs4291-AT (P <0.04) showed better blood pressure lowering effects.	Creatinine	129-139	angiotensin I converting enzyme	Homo sapiens	76-79
31719297-11	2019	Interpretation & conclusions: Pharmacological response of blood pressure and creatinine clearance to ACE inhibitors and statins may be genetically mediated.	Creatinine	77-87	angiotensin I converting enzyme	Homo sapiens	101-104
31356560-6	2019	Expression of DcR3 was correlated with a 2-fold increase in serum creatinine or failure of kidney allograft.	Creatinine	66-76	TNF receptor superfamily member 6b	Homo sapiens	14-18
31400547-8	2019	The OCN levels were correlated with the eGFR (p = 0.002), tooth loss (p = 0.023), blood urea nitrogen (p = 0.040), and creatinine levels (p = 0.031).	Creatinine	119-129	bone gamma-carboxyglutamate protein	Homo sapiens	4-7
31347464-6	2019	Urine NAG index was significantly correlated with urinary fractional excretion of sodium (FENa; rho = 0.76, p < 0.001) and plasma creatinine (rho = 0.74, p = 0.001).	Creatinine	130-140	N-acetyl-alpha-glucosaminidase	Homo sapiens	6-9
31381195-12	2019	There was a strong correlation between vWF:Ag:vWF:CBA and creatinine (r = 0.859; P < .001), but no other variables.	Creatinine	58-68	von Willebrand factor	Homo sapiens	39-42
31381195-12	2019	There was a strong correlation between vWF:Ag:vWF:CBA and creatinine (r = 0.859; P < .001), but no other variables.	Creatinine	58-68	von Willebrand factor	Homo sapiens	46-49
31517819-8	2019	Both the frequency of AR and levels of creatinine (3 and 6 months after KTx) were significantly higher in patients with an increased CD200R1/CD200 ratio (median: 126 vs 78, P = .008).	Creatinine	39-49	CD200 receptor 1	Homo sapiens	133-140
30010903-5	2019	RESULTS: The plasma fractalkine levels in IgAN patients were significantly correlated with the creatinine level and 24-h urine protein by both univariate and multivariate analysis.	Creatinine	95-105	C-X3-C motif chemokine ligand 1	Homo sapiens	20-31
31339657-8	2019	CSN6 expression was significantly correlated with patients with high pathological stage (P = .006), male gender (P = .025), and high serum creatinine levels (P = .014).	Creatinine	139-149	COP9 signalosome subunit 6	Homo sapiens	0-4
30010903-11	2019	CONCLUSIONS: Plasma fractalkine levels were associated with creatinine level, 24-h urine protein, mesangial hypercellularity pathological damage, the CD68+ macrophage and CD20+ B cell infiltration in renal tissue and renal outcome in IgAN patients.	Creatinine	60-70	C-X3-C motif chemokine ligand 1	Homo sapiens	20-31
31485275-7	2019	The expression of mTOR was correlated with serum creatinine, blood urea nitrogen, estimated glomerular filtration rate, 24 h proteinuria, and cystatin C.	Creatinine	49-59	mechanistic target of rapamycin kinase	Homo sapiens	18-22
31470789-7	2019	After excluding patients who were diagnosed as AKI for creatinine level at admission, urinary L-FABP could predict the onset of AKI after admission (p &lt; 0.001).	Creatinine	55-65	fatty acid binding protein 1	Homo sapiens	94-100
31534958-3	2019	FcgRIII-/- diabetic mice and FcgRIIb-/- diabetic mice had elevated levels of serum creatinine compared with wildtype (WT) diabetic mice.	Creatinine	83-93	Fc receptor, IgG, low affinity IIb	Mus musculus	29-36
31406124-9	2019	In diabetic mice, PRR knockdown decreased urine albumin to creatinine ratio and the renal expressions of PRR, NOX4, UCP2, caspase3, phos-FOXO3a, phos-NF-kappaB, collagen, and fibronectin, while increased the renal mitochondria expression and activity of SOD2, ATP production, and the renal expressions of Sirt1 and total-FOXO3a.	Creatinine	59-69	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	18-21
31202596-5	2019	The association between the ratio of preoperative urinary concentrations of DKK3 to creatinine (DKK3:creatinine) and postoperative AKI, defined according to the Kidney Disease Improving Global Outcomes criteria, and subsequent kidney function loss, as determined by estimated glomerular filtration rate, was assessed.	Creatinine	84-94	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	96-100
31202596-6	2019	FINDINGS: In the 733 patient in the derivation cohort, urinary concentrations of DKK3 to creatinine that were higher than 471 pg/mg were associated with significantly increased risk for AKI (odds ratio [OR] 1 65, 95% CI 1 10-2 47, p=0 015), independent of baseline kidney function.	Creatinine	89-99	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	81-85
31202596-7	2019	Compared with clinical and other laboratory measurements, urinary concentrations of DKK3:creatinine significantly improved AKI prediction (net reclassification improvement 0 32, 95% CI 0 23-0 42, p&lt;0 0001).	Creatinine	89-99	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	84-88
31202596-8	2019	High urinary DKK3:creatinine concentrations were independently associated with significantly lower kidney function at hospital discharge and after a median follow-up of 820 days (IQR 733-910).	Creatinine	18-28	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	13-17
31202596-9	2019	In the RenalRIP trial, preoperative urinary DKK3:creatinine concentrations higher than 471 pg/mg were associated with a significantly higher risk for AKI (OR 1 94, 95% CI 1 08-3 47, p=0 026), persistent renal dysfunction (OR 6 67, 1 67-26 61, p=0 0072), and dialysis dependency (OR 13 57, 1 50-122 77, p=0 020) after 90 days compared with DKK3:creatinine concentrations of 471 pg/mg or less.	Creatinine	49-59	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	44-48
31202596-9	2019	In the RenalRIP trial, preoperative urinary DKK3:creatinine concentrations higher than 471 pg/mg were associated with a significantly higher risk for AKI (OR 1 94, 95% CI 1 08-3 47, p=0 026), persistent renal dysfunction (OR 6 67, 1 67-26 61, p=0 0072), and dialysis dependency (OR 13 57, 1 50-122 77, p=0 020) after 90 days compared with DKK3:creatinine concentrations of 471 pg/mg or less.	Creatinine	49-59	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	339-343
31202596-9	2019	In the RenalRIP trial, preoperative urinary DKK3:creatinine concentrations higher than 471 pg/mg were associated with a significantly higher risk for AKI (OR 1 94, 95% CI 1 08-3 47, p=0 026), persistent renal dysfunction (OR 6 67, 1 67-26 61, p=0 0072), and dialysis dependency (OR 13 57, 1 50-122 77, p=0 020) after 90 days compared with DKK3:creatinine concentrations of 471 pg/mg or less.	Creatinine	344-354	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	44-48
31202596-10	2019	Urinary DKK3:creatinine concentrations higher than 471 pg/mg were associated with significantly higher risk for AKI (OR 2 79, 95% CI 1 45-5 37) and persistent renal dysfunction (OR 3 82, 1 32-11 05) only in patients having a sham procedure, but not remote ischaemic preconditioning (AKI OR 1 35, 0 76-2 39 and persistent renal dysfunction OR 1 05, 0 12-9 45).	Creatinine	13-23	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	8-12
31248950-12	2019	CONCLUSIONS: Adding esaxerenone at 1.25, 2.5, and 5 mg/d for 12 weeks to an ongoing renin-angiotensin system inhibitor significantly reduces urinary albumin-to-creatinine ratio in patients with type 2 diabetes mellitus and microalbuminuria.	Creatinine	160-170	renin	Homo sapiens	84-89
31485449-1	2019	Introduction: Urinary C-peptide creatinine ratio (UCPCR) is used as a marker of endogenous insulin secretion.	Creatinine	32-42	insulin	Homo sapiens	91-98
31447785-0	2019	Correlation Between Serum miR-154-5p and Osteocalcin in Males and Postmenopausal Females of Type 2 Diabetes With Different Urinary Albumin Creatinine Ratios.	Creatinine	139-149	bone gamma-carboxyglutamate protein	Homo sapiens	41-52
31287495-9	2019	IGFBP7 knockdown effectively attenuated renal fibrosis, concentrations of Cr, BUN and ALB, and activation of ERK1/2 signaling in CLP-induced mice.	Creatinine	74-76	insulin-like growth factor binding protein 7	Mus musculus	0-6
31187425-8	2019	At PET, dialysate copeptin negatively correlated with D/P creatinine (Rs = - 0.35, p = 0.033), and positively with D/D0 glucose (Rs = 0.33, p = 0.045) and ultrafiltration (Rs = 0.37, p = 0.024).	Creatinine	58-68	arginine vasopressin	Homo sapiens	18-26
31187425-9	2019	Multivariate analysis showed that low dialysate copeptin (beta = -0.30, p = 0.049) and high dialysate IL-6 (beta = + 0.40, p = 0.012) were independent determinants of higher D/P creatinine.	Creatinine	178-188	interleukin 6	Homo sapiens	102-106
31187425-10	2019	CONCLUSIONS: Dialysate copeptin was negatively associated with D/P creatinine in incident PD patients suggesting a potential influence of copeptin or AVP on peritoneal solute transport rate that might involve vasoactive mechanisms.	Creatinine	67-77	arginine vasopressin	Homo sapiens	23-31
30126709-8	2019	IGF-1 was positively correlated with body mass index, hemoglobin, albumin, pre-albumin, retinol-binding protein (RBP), transferrin, serum creatinine (Scr) and cholesterol (p &lt; 0.05 for all).	Creatinine	138-148	insulin like growth factor 1	Homo sapiens	0-5
31222653-6	2019	The results revealed that the two actinomycete extracts S19 and G30 could significantly (p < 0.01) lower the elevated levels of serum creatinine, urea, and uric acid caused by the CCl4 administration.	Creatinine	134-144	C-C motif chemokine ligand 4	Rattus norvegicus	180-184
31151073-12	2019	We further proved that plasma HDL cholesterol and homocysteine level, in addition to eGFR by serum creatinine, were associated with VPA-induced HA risk independently from rs1047891 polymorphism.	Creatinine	99-109	epidermal growth factor receptor	Homo sapiens	85-89
31501383-5	2019	The examination of protein/creatinine ratio was useful for continuing anti-VEGF therapy.	Creatinine	27-37	vascular endothelial growth factor A	Homo sapiens	75-79
31250339-7	2019	The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P &lt; 0.001).	Creatinine	42-52	interleukin 6	Homo sapiens	156-169
31250339-7	2019	The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P &lt; 0.001).	Creatinine	42-52	tumor necrosis factor	Homo sapiens	182-209
31144454-2	2019	After chromatographic separation on an ACE Excel 2 AQ column, high abundant creatinine and uric acid and the other low abundant purines were sequentially detected by ultraviolet and quadrupole time-of-flight mass spectrometry within a single run.	Creatinine	76-86	angiotensin I converting enzyme	Homo sapiens	39-42
31204473-7	2019	The mean concentration of BaP-3-S was 0.67 ng g-1 creatinine (<LOD to 10.20 ng g-1 creatinine), about 10-fold lower than that of BaP-3-G (6.73 ng g-1 creatinine, < LOD to 52.64 ng g-1 creatinine).	Creatinine	50-60	BAI1 associated protein 3	Homo sapiens	26-31
31204473-7	2019	The mean concentration of BaP-3-S was 0.67 ng g-1 creatinine (<LOD to 10.20 ng g-1 creatinine), about 10-fold lower than that of BaP-3-G (6.73 ng g-1 creatinine, < LOD to 52.64 ng g-1 creatinine).	Creatinine	83-93	BAI1 associated protein 3	Homo sapiens	26-31
31204473-7	2019	The mean concentration of BaP-3-S was 0.67 ng g-1 creatinine (<LOD to 10.20 ng g-1 creatinine), about 10-fold lower than that of BaP-3-G (6.73 ng g-1 creatinine, < LOD to 52.64 ng g-1 creatinine).	Creatinine	83-93	BAI1 associated protein 3	Homo sapiens	26-31
31204473-7	2019	The mean concentration of BaP-3-S was 0.67 ng g-1 creatinine (<LOD to 10.20 ng g-1 creatinine), about 10-fold lower than that of BaP-3-G (6.73 ng g-1 creatinine, < LOD to 52.64 ng g-1 creatinine).	Creatinine	83-93	BAI1 associated protein 3	Homo sapiens	26-31
31391726-6	2019	eGFR was negatively correlated with visfatin (r = -0.323, p = 0.034), irisin (r = -0.324, p = 0.034), urine albumin (r = -0.443, p = 0.003) and albumin creatinine ratio (r = -0.419, p = 0.005) in patients with diabetic nephropathy.	Creatinine	152-162	epidermal growth factor receptor	Homo sapiens	0-4
31288784-15	2019	Quantitative PCR detected AQP1 in both kidney-transplanted and non-transplanted individuals during the phase of creatinine decline.	Creatinine	112-122	aquaporin 1 (Colton blood group)	Homo sapiens	26-30
31308681-14	2019	Only urinary orosomucoid and urinary orosomucoid/urinary creatinine (u-ORM/u-CREAT) ratio showed significant correlation with QRISK score (u-ORM, r=0.245; u-ORM/u-CREAT, r=0.309).	Creatinine	57-67	orosomucoid 1	Homo sapiens	71-74
31079532-4	2019	Active renin was increased in urine samples from patients with DKD (n=36), compared with those without DKD (n=38; 3.2 versus 1.3 pg/mg creatinine; P&lt;0.001).	Creatinine	135-145	renin	Homo sapiens	7-12
31091125-7	2019	Seventy-two hours after cisplatin injection, increased serum creatinine concentrations and renal tubular injury accompanied by apoptosis and oxidative stress were more prominent in VASH1+/- mice than in WT mice.	Creatinine	61-71	LOC105242496	Mus musculus	181-186
30817089-9	2019	More importantly, Akt and CD9 levels in urinary exosomes were higher in UTI patients than in ABU patients, which was also observed after correction by urine creatinine.	Creatinine	157-167	AKT serine/threonine kinase 1	Homo sapiens	18-21
30637733-8	2019	The upregulation of miR-424 improved renal lesion and DN symptoms of blood glucose level, urine protein level, body weight, creatinine level, blood urea nitrogen, and KW/BW ratio.	Creatinine	124-134	microRNA 424	Homo sapiens	20-27
31077989-3	2019	For GF-1, PFOA, PFOS, and PFHxS were positively and significantly associated with serum creatinine.	Creatinine	88-98	GATA binding protein 1	Homo sapiens	4-8
31173609-5	2019	Patients with CRS were older (p<0.001), with more diabetes mellitus (p<0.001), coronary heart history (p<0.001), higher estimated glomerular filtration rate (eGFR) (p<0.001), lower serum creatinine (p<0.001) and phosphorus levels (p = 0.003) compared to non-CRS patients.	Creatinine	187-197	twist family bHLH transcription factor 1	Homo sapiens	14-17
30720852-7	2019	RESULTS: The results of this study showed that MIF antagonist (p425) significantly decreased urine protein and GAG excretion, urine protein/creatinine ratio, and serum BUN and Cr in the streptozotocin-induced DN in the rats.	Creatinine	140-150	macrophage migration inhibitory factor	Rattus norvegicus	47-50
31497427-12	2019	Of the five individuals in whom anti-myeloperoxidase (MPO) antibody was strongly positive, all had renal involvement defined by an elevated creatinine with three having biopsy-proven lupus nephritis.	Creatinine	140-150	myeloperoxidase	Homo sapiens	37-52
31497427-12	2019	Of the five individuals in whom anti-myeloperoxidase (MPO) antibody was strongly positive, all had renal involvement defined by an elevated creatinine with three having biopsy-proven lupus nephritis.	Creatinine	140-150	myeloperoxidase	Homo sapiens	54-57
30778862-5	2019	RESULTS: Median urine protein to creatinine ratios in the MMF and IVCY groups significantly decreased from 2.2 to 0.7 g/gCr and from 3.3 to 0.5 g/gCr, respectively.	Creatinine	33-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	120-123
29729954-6	2019	Also, urinary levels of C3a and C5a were significantly correlated with serum creatinine, urinary protein and estimated glomerular filtration rate, whereas urinary sC5b-9 was significantly correlated with the latter two (and not serum creatinine).	Creatinine	77-87	complement C5a receptor 1	Homo sapiens	32-35
30762290-2	2019	As BW may affect muscle mass, creatinine-based eGFR can be altered independently of kidney function.	Creatinine	30-40	epidermal growth factor receptor	Homo sapiens	47-51
29895473-5	2019	Increased urinary albumin excretion was defined as albumin-to-creatinine ratio (ACR) 30 mg/g or greater.	Creatinine	62-72	albumin	Homo sapiens	18-25
29895473-5	2019	Increased urinary albumin excretion was defined as albumin-to-creatinine ratio (ACR) 30 mg/g or greater.	Creatinine	62-72	albumin	Homo sapiens	51-58
30889420-10	2019	Urinary beta2-MG levels &lt;300 mug/g creatinine were associated with 4.66 (95% CI: 1.92, 11.32) fold increase in the POR for low GFR, compared with urinary beta2-MG levels &lt;100 mug/g creatinine.	Creatinine	38-48	cytochrome p450 oxidoreductase	Homo sapiens	118-121
30378108-11	2019	Furthermore, VEGF-C decreased the urinary albumin/creatinine ratio and blood pressure as well as glomerular and tubular damages.	Creatinine	50-60	vascular endothelial growth factor C	Mus musculus	13-19
30099700-8	2019	TLR4 deficiency ameliorated renal dysfunction (serum BUN and creatinine) and tubular endothelial apoptosis determined by immunofluorescence staining of CD31 and TUNEL, and western blot of apoptotic protein (caspase-3, c-caspase-3, and Bax/Bcl-2 ratio).	Creatinine	61-71	toll-like receptor 4	Mus musculus	0-4
30968541-3	2019	Clinically, plasma and urinary MIF levels were largely elevated at the onset of AKI, declined to normal levels when AKI was resolved and correlated tightly with serum creatinine independent of disease causes.	Creatinine	167-177	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	31-34
30968541-4	2019	Experimentally, MIF levels in plasma and urine were rapidly elevated after IRI-AKI and associated with the elevation of serum creatinine and the severity of tubular necrosis, which were suppressed in MIF KO mice.	Creatinine	126-136	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	16-19
30968541-4	2019	Experimentally, MIF levels in plasma and urine were rapidly elevated after IRI-AKI and associated with the elevation of serum creatinine and the severity of tubular necrosis, which were suppressed in MIF KO mice.	Creatinine	126-136	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	200-203
31144038-8	2019	Fluorescence drops in the 0 to 20 muM creatinine concentration range, and the limit of detection is 0.14 muM.	Creatinine	38-48	latexin	Homo sapiens	34-37
30676168-4	2019	CCl4 showed an increase of serum hepatic and renal markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine.	Creatinine	135-145	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
30801542-4	2019	METHODS: Urine excretion of 6 AngII-regulated proteins was quantified using selected reaction monitoring and normalized by urine creatinine.	Creatinine	129-139	angiotensinogen	Homo sapiens	30-35
31245009-6	2019	Results: The urinary adiponectin levels were 14.88+-3.16 (ng/mg creatinine, mean+-SEM) for patients with DM, and 3.06+-0.33 (ng/mg creatinine) for normal subjects.	Creatinine	64-74	adiponectin, C1Q and collagen domain containing	Homo sapiens	21-32
31144038-8	2019	Fluorescence drops in the 0 to 20 muM creatinine concentration range, and the limit of detection is 0.14 muM.	Creatinine	38-48	latexin	Homo sapiens	105-108
31183108-2	2019	We demonstrate that in newly diagnosed CMML patients, plasma lysozyme levels are positively correlated with both absolute monocyte count and serum creatinine.	Creatinine	147-157	lysozyme	Homo sapiens	61-69
30713297-5	2019	The dose of S-1 was determined by the body surface area and creatinine clearance.	Creatinine	60-70	proteasome 26S subunit, non-ATPase 1	Homo sapiens	12-15
30638235-0	2019	Transformation of the hydride-containing dinitrosyl iron complex [(NO)2Fe(eta2-BH4)]- into [(NO)2Fe(eta3-HCS2)]-via reaction with CS2.	Creatinine	22-29	chorionic somatomammotropin hormone 2	Homo sapiens	106-109
31134161-5	2019	Blocking the C5a-C5aR1 axis resulted in a decrease in the albumin-to-creatinine ratio, and the attenuation of kidney damage in IgAN and RSV-IgAN mice might be partly attributed to the inhibition of Th cell and cytokine dysfunction.	Creatinine	69-79	complement C5a receptor 1	Homo sapiens	17-22
30529215-10	2019	Significant TR was associated with increased maximum postoperative plasma creatinine (median [interquartile range], 2.2 [1.5 to 3.2] mg/dL vs 1.8 [1.4 to 2.6] mg/dL, p = 0.008), prolonged postoperative stay (median [interquartile range], 12 [9 to 21] days vs 10 [8 to 14] days; p < 0.001), and decreased adjusted survival.	Creatinine	74-84	coagulation factor II thrombin receptor	Homo sapiens	12-14
31053735-5	2019	Moreover, urinary Gremlin levels were correlated with the number of glomerular crescents (r = 0.53; p &lt; 0.001), renal CD68 positive cells (r = 0.71; p &lt; 0.005), tubulointerstitial fibrosis (r = 0.50; p &lt; 0.05), and serum creatinine levels (r = 0.60; p &lt; 0.001).	Creatinine	230-240	gremlin 1, DAN family BMP antagonist	Homo sapiens	18-25
30847568-4	2019	The probe NCP-Pd displays excellent detecting performance with respect to creatinine such as good water solubility, high selectivity, and a low detection limit (0.16 muM).	Creatinine	74-84	latexin	Homo sapiens	166-169
31101169-10	2019	We propose that predonation serum creatinine is positively correlated with 8-0HdG/dG ratio and negatively correlated with antioxidant PON activity.	Creatinine	34-44	paraoxonase 1	Homo sapiens	134-137
31091993-10	2019	Using correlation heatmaps and hierarchical cluster analyses, PENK clustered with estimated glomerular filtration rate, creatinine, NGAL, galectin-3, and urea.	Creatinine	120-130	proenkephalin	Homo sapiens	62-66
30700847-5	2019	Compared to wild-type (WT) mice with a renal IRI, IL-10 knockout (IL-10 KO) mice with IRI demonstrated decreased renal function as represented by blood urea nitrogen and serum creatinine, upregulated early acute kidney injury (AKI) biomarkers such as kidney injury molecule-1 (Kim-1), increased mRNA expression of the pro-inflammatory cytokines IL-1beta, IL-6, and IL-18 and a chemokine (regulated on activation, normal T cell expressed and secreted; RANTES), and increased expression of the pro-apoptosis factors Bax and cleaved caspase-3.	Creatinine	176-186	interleukin 10	Mus musculus	50-55
29718360-7	2019	A targeted metabolite panel eGFR developed in the AASK and validated in the MESA was more accurate (1-P30 3.7 and 1.9%, respectively) than eGFRcr [11.2 and 18.5%, respectively (P < 0.001 for both)] and estimating GFR using cystatin C (eGFRcys) [10.6% (P = 0.02) and 9.1% (P < 0.05), respectively] but was not consistently better than eGFR using both creatinine and cystatin C [3.7% (P > 0.05) and 9.1% (P < 0.05), respectively].	Creatinine	350-360	epidermal growth factor receptor	Homo sapiens	28-32
31101174-14	2019	The rejection group maintained higher levels of IL-8 for 11 days (range: 7-30) compared to the SGF group (P = .002) and the IL-8 levels correlated with serum creatinine levels (r = 0.621, P = .001).	Creatinine	158-168	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
31040360-4	2019	BMF-Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice.	Creatinine	70-80	BCL2 modifying factor	Mus musculus	0-3
31249229-12	2019	There was a significant difference between the eGFR-Cr and eGFR-cystatin C in the obese participants (97.4 +- 21.4 vs. 75.4 +- 38.9 mL/min/1.73 m2), P = 0.019).	Creatinine	52-54	epidermal growth factor receptor	Homo sapiens	47-51
31139647-11	2019	PSP/REG Ialpha was negatively correlated with eGFR (r = -0.402, p &lt; 0.001) and positively associated with serum Cr (r = 0.468, p &lt; 0.001), BUN (r = 0.166, p &lt; 0.001), and UA (r = 0.207, p &lt; 0.001).	Creatinine	115-117	regenerating family member 1 alpha	Homo sapiens	0-3
31034503-6	2019	FSTL1 concentration was positively correlated with high-sensitivity C-reactive protein (hsCRP), serum creatinine, and N-terminal pro b-type natriuretic peptide (all P &lt; 0.01).	Creatinine	102-112	follistatin like 1	Homo sapiens	0-5
30958432-9	2019	Fibrinogen was significantly associated with all-cause mortality according to multivariate Cox regression (hazard ratio 1.339, 95% confidence interval: 1.109-1.763, P = 0.005), together with traditional risk factors including age, sex, diabetes mellitus, left ventricular ejection fraction, creatinine clearance, and low-density lipoprotein cholesterol.	Creatinine	291-301	fibrinogen beta chain	Homo sapiens	0-10
30996242-4	2019	Ang II-infused mice exhibited hypertension, cardiac hypertrophy, increases in blood urea nitrogen and serum creatinine, moderate albuminuria and renal pathological changes such as mild urinary cast, interstitial macrophage infiltration and modest interstitial fibrosis.	Creatinine	108-118	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
31139647-11	2019	PSP/REG Ialpha was negatively correlated with eGFR (r = -0.402, p &lt; 0.001) and positively associated with serum Cr (r = 0.468, p &lt; 0.001), BUN (r = 0.166, p &lt; 0.001), and UA (r = 0.207, p &lt; 0.001).	Creatinine	115-117	regenerating family member 1 alpha	Homo sapiens	4-7
30951521-15	2019	Over a median (IQR) 36 (24 to 37) months of follow-up, 9 patients on octreotide-LAR and 21 patients on placebo progressed to a doubling of serum creatinine or ESRD (composite endpoint) (hazard ratio [HR] [95% CI] adjusted for age, sex, baseline serum creatinine, and baseline TKV: 0.307 [0.127 to 0.742], p = 0.009).	Creatinine	145-155	protein tyrosine phosphatase receptor type F	Homo sapiens	80-83
30920848-4	2019	Results: NAG showed among others significant correlation with N-terminal pro brain natriuretic peptide (NTproBNP), troponin I and creatinine.	Creatinine	130-140	N-acetyl-alpha-glucosaminidase	Homo sapiens	9-12
30969095-7	2019	Multivariate stepwise principal component regression analysis indicated that calcifediol, hemoglobin A1c, and serum creatinine were independent risk factors for elevated CEA in T2DM.	Creatinine	116-126	CEA cell adhesion molecule 3	Homo sapiens	170-173
31303142-10	2019	The creatinine-based estimated glomerular filtration rate decreased by a mean of -8.4 ml/min/1.73 m2, but tubular renal parameters improved.	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
30970397-4	2019	The eGFR was calculated using an equation combined serum creatinine and cystatin C.	Creatinine	57-67	epidermal growth factor receptor	Homo sapiens	4-8
30984258-6	2019	For predicting POF, serum creatinine level &gt;= 1.8 mg/dl had the highest specificity (98%).	Creatinine	26-36	POF1B actin binding protein	Homo sapiens	15-18
30984258-8	2019	Conclusions: In this large, hospital-based retrospective study, we demonstrated that an APACHE-II score &gt;= 8 and a serum creatinine level &gt;= 1.8 mg/dl within 24 h of admission can positively predict POF in AP and that serum creatinine levels &lt; 1.8 mg/dl within 24 h of admission can be useful for negatively predicting POF in AP.	Creatinine	124-134	POF1B actin binding protein	Homo sapiens	205-208
30984258-8	2019	Conclusions: In this large, hospital-based retrospective study, we demonstrated that an APACHE-II score &gt;= 8 and a serum creatinine level &gt;= 1.8 mg/dl within 24 h of admission can positively predict POF in AP and that serum creatinine levels &lt; 1.8 mg/dl within 24 h of admission can be useful for negatively predicting POF in AP.	Creatinine	124-134	POF1B actin binding protein	Homo sapiens	328-331
30984258-8	2019	Conclusions: In this large, hospital-based retrospective study, we demonstrated that an APACHE-II score &gt;= 8 and a serum creatinine level &gt;= 1.8 mg/dl within 24 h of admission can positively predict POF in AP and that serum creatinine levels &lt; 1.8 mg/dl within 24 h of admission can be useful for negatively predicting POF in AP.	Creatinine	230-240	POF1B actin binding protein	Homo sapiens	205-208
30845182-3	2019	Administration of CPE at doses of 100, 200, and 400 mg/kg for 45 days has produced significant attenuation of elevated biochemical parameters including serum glucose, lipid and creatinine levels.	Creatinine	177-187	carboxypeptidase E	Rattus norvegicus	18-21
30845182-4	2019	CPE has also reserved albuminuria and elevated creatinine clearance in treated diabetic rats.	Creatinine	47-57	carboxypeptidase E	Rattus norvegicus	0-3
30304543-8	2019	MiR-101a mimics significantly improved GFR and inhibited AngII-induced increase in the ratio of urine albumin to creatinine, BUN and Scr.	Creatinine	113-123	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	57-62
31041219-9	2019	CD4 count had a significant positive correlation with creatinine clearance, hyponatremia and total leukocyte count, and significant negative correlation with duration of disease and proteinuria.	Creatinine	54-64	CD4 molecule	Homo sapiens	0-3
30994004-7	2019	CvEO (100 mg/kg) caused significant reductions in CCl4-elevated levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, total cholesterol, triglycerides, low-density lipoprotein, urea, and creatinine and increased the level of high-density lipoprotein compared with the untreated group.	Creatinine	262-272	C-C motif chemokine ligand 4	Rattus norvegicus	50-54
30632900-5	2019	In pulmonary arterial hypertension patients, the urinary albumin to creatinine ratio was associated with older age, lower six-minute walking distance, elevated levels of C-reactive protein and hemoglobin A1c, but there was no correlation between the urinary albumin to creatinine ratio and hemodynamic variables.	Creatinine	68-78	C-reactive protein	Homo sapiens	170-188
30909873-9	2019	In multivariable linear regression analysis, the urinary AGT/creatinine (Cr) ratio was negatively correlated with the serum potassium level (beta = - 0.058, P = 0.017) and positively correlated with the transtubular potassium gradient (TTKG, beta = 0.087, P = 0.001).	Creatinine	61-71	angiotensinogen	Homo sapiens	57-60
30936736-3	2019	Methods: We retrospectively examined the effects of ACEI/A2RB usage and CRS1 development (in-hospital change in serum creatinine &gt;=0.3 mg/dL or &gt;=0.5 mg/dL), as well as their potential interaction, on in-hospital mortality among elderly ADCHF patients (aged &gt;=65 years).	Creatinine	118-128	twist family bHLH transcription factor 1	Homo sapiens	72-76
30866052-4	2019	eGFR was calculated by a four-variable MDRD equation (eGFRMDRD ), CKD-EPI creatinine equations (eGFRC r ), CKD-EPI Cystatin C equation (eGFRC ys ), and CKD-EPI Creatinine-Cystatin equation (eGFRC rC ys ).	Creatinine	74-84	epidermal growth factor receptor	Homo sapiens	0-4
30866052-4	2019	eGFR was calculated by a four-variable MDRD equation (eGFRMDRD ), CKD-EPI creatinine equations (eGFRC r ), CKD-EPI Cystatin C equation (eGFRC ys ), and CKD-EPI Creatinine-Cystatin equation (eGFRC rC ys ).	Creatinine	160-170	epidermal growth factor receptor	Homo sapiens	0-4
30787165-7	2019	Creatinine concentrations were significantly reduced in SBMA, and strongly and significantly correlated with disease severity.	Creatinine	0-10	androgen receptor	Homo sapiens	56-60
30787165-9	2019	Creatinine, but not CK, correlated with disease severity, confirming its role as a valuable biomarker in SBMA.	Creatinine	0-10	androgen receptor	Homo sapiens	105-109
31074416-10	2019	The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine.	Creatinine	101-111	interleukin 2	Homo sapiens	14-18
31074416-10	2019	The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine.	Creatinine	101-111	interleukin 4	Homo sapiens	20-24
31074416-10	2019	The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine.	Creatinine	101-111	interferon gamma	Homo sapiens	33-42
30575313-12	2019	The gld.apoE- / - mice have high levels of serum creatinine.	Creatinine	49-59	apolipoprotein E	Mus musculus	8-12
29464358-0	2019	Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture.	Creatinine	31-41	epidermal growth factor receptor	Homo sapiens	48-52
30949530-8	2019	Bivariate analysis identified only baseline creatinine clearance &gt;80 mL min-1 (Cockcroft-Gault) as a possible predictor of SVR12 failure (P = .026).	Creatinine	44-54	CD59 molecule (CD59 blood group)	Homo sapiens	75-80
31086503-8	2019	Excluding dialysis patients, Creatinine clearance was 21.1+-6.6ml/min/1.73m2.	Creatinine	29-39	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
30949530-9	2019	In the multivariate analysis, pretreatment creatinine clearance &gt;80 mL min-1 remained independently associated with SVR12 failure (odds ratio, 2.95; 95% confidence interval, 1.17-7.46; P = .023).	Creatinine	43-53	CD59 molecule (CD59 blood group)	Homo sapiens	74-79
30949530-10	2019	Conclusions: In hepatitis C patients treated with LDV/SOF, a pretreatment creatinine clearance of &gt;80 mL min-1 was associated with SVR12 failure.	Creatinine	74-84	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
30853986-10	2019	The alkaline picrate color on muPAD changed from yellow to orange in the presence of creatinine and the orange intensity is directly proportional to the creatinine amount in a linearity range of 0.20-6.0 mM as a detection limit of 180 muM.	Creatinine	153-163	latexin	Homo sapiens	235-238
30761853-7	2019	Fetuin-A was negatively correlated with creatinine (P &lt; 0.001), Ca x P product (P &lt; 0.001), hs-CRP (P = 0.01), vascular calcification score (P &lt; 0.001), and CIMT (P &lt; 0.001), and positively correlated with BMI (P &lt; 0.001, r = 0.30) and serum albumin (P &lt; 0.001).	Creatinine	40-50	alpha 2-HS glycoprotein	Homo sapiens	0-8
30551062-3	2019	The normal level of creatinine in the serum and its excretion through urine in apparently healthy individuals is 45-140 muM and 0.8-2.0 gm/day respectively.	Creatinine	20-30	latexin	Homo sapiens	120-123
30551062-4	2019	The level of creatinine reaches &gt;1000 muM in serum during renal, thyroid and kidney dysfunction or muscle disorder.	Creatinine	13-23	latexin	Homo sapiens	41-44
30536192-7	2019	In vivo, elevated serum PEDF led to proteinuria, increased serum creatinine, and podocyte foot process fusion in normal or diabetic mice.	Creatinine	65-75	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	24-28
30193001-6	2019	RESULTS: Baseline urinary Hcy-thiolactone/creatinine was significantly associated with plasma tHcy, ApoA1, glomerular filtration rate, potassium and pyridoxal 5"-phosphate (positively) and with age, hypertension, smoking, urinary creatinine, plasma bilirubin and kynurenine (negatively).	Creatinine	42-52	apolipoprotein A1	Homo sapiens	100-105
30320415-5	2019	The correlation analysis analyzed the correlations of CD62P and P10 markers with serum creatinine (Scr), blood urea nitrogen (BUN), and subjective score; and logistic regression analysis was performed to reveal factors affecting the efficacy of HD.	Creatinine	87-97	S100 calcium binding protein A10	Homo sapiens	64-67
30809550-9	2019	The multivariate logistic regression showed that cyt c was an independent risk factor for the occurrence of CIN (OR, 7.421; 95% CI, 6.471-20.741; P = 0.034) after adjusting for age, history of hypertension and diabetes mellitus, levels of creatinine, uric acid, and glucose.	Creatinine	239-249	cytochrome c, somatic	Homo sapiens	49-54
30641999-6	2019	A correlation analysis showed that plasma zonulin level was positively correlated to body mass index (BMI), creatinine, fasting plasma glucose, baseline, first hour, and two hours glucose levels and the OGTT, hemoglobin A1C (HbA1C), homeostatic model assessment for insulin resistance (HOMA-IR), and alanine aminotransferase (ALT) levels.	Creatinine	108-118	haptoglobin	Homo sapiens	42-49
31583093-14	2019	Strikingly, L-FABP >9.8 microg/g creatinine had 100% accuracy in predicting post-PTX-related AKI.	Creatinine	33-43	fatty acid binding protein 1	Homo sapiens	12-18
30634720-5	2019	The in vivo investigation showed that NGR1 treatment increased serum lipid, beta2-microglobulin, serum creatinine, and blood urea nitrogen levels of db/db mice.	Creatinine	103-113	reticulon 4 receptor	Mus musculus	38-42
31334040-9	2019	Hexosaminidase was correlated with the level of proteinuria, while COX-2 was correlated with interstitial inflammation and serum creatinine level in the disease group.	Creatinine	129-139	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-72
31405691-8	2019	Abnormal Albumin: Creatinine Ratios (Alb/Cr), were found in 23%.	Creatinine	18-28	albumin	Homo sapiens	9-12
30303710-8	2019	Higher serum and urinary SOD3 levels were observed in the group of patients with diabetes and CKD, which had higher albuminuria and serum creatinine levels.	Creatinine	138-148	superoxide dismutase 3	Homo sapiens	25-29
30303710-9	2019	The serum SOD3 levels were significantly positively correlated with renal function, according to the serum creatinine level.	Creatinine	107-117	superoxide dismutase 3	Homo sapiens	10-14
30303710-11	2019	Furthermore, albuminuria can positively predict the serum SOD3 level for the ratio of urinary albumin to urinary creatinine (ACR) >1,190.769 mg/g and the urinary SOD3 level for ACR >=300 mg/g.	Creatinine	113-123	superoxide dismutase 3	Homo sapiens	58-62
30384070-10	2019	Children in the highest urinary TDGA quartile (&gt;=160.0 mug/g creatinine) exhibited significantly elevated median AST levels compared with those in the lowest quartiles (&lt;35.4 mug/g creatinine, p = 0.033).	Creatinine	64-74	solute carrier family 17 member 5	Homo sapiens	116-119
30651805-4	2019	The correlation of in vivo creatinine (Cr) with C-reactive protein (CRP), TNF-alpha, BMD and vitamin D deficiency were analyzed.	Creatinine	39-41	C-reactive protein	Homo sapiens	48-66
30651805-8	2019	Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P&lt;0.001), as well as between Cr and TNF-alpha (r=0.8969, P&lt;0.001); and negative correlation between Cr and BMD (r=0.5472, P&lt;0.001), and between Cr and 25(OH)D (r=0.4733, P&lt;0.001).	Creatinine	59-61	C-reactive protein	Homo sapiens	66-69
30651805-8	2019	Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P&lt;0.001), as well as between Cr and TNF-alpha (r=0.8969, P&lt;0.001); and negative correlation between Cr and BMD (r=0.5472, P&lt;0.001), and between Cr and 25(OH)D (r=0.4733, P&lt;0.001).	Creatinine	113-115	tumor necrosis factor	Homo sapiens	120-129
30651805-8	2019	Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P&lt;0.001), as well as between Cr and TNF-alpha (r=0.8969, P&lt;0.001); and negative correlation between Cr and BMD (r=0.5472, P&lt;0.001), and between Cr and 25(OH)D (r=0.4733, P&lt;0.001).	Creatinine	113-115	tumor necrosis factor	Homo sapiens	120-129
30651805-8	2019	Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P&lt;0.001), as well as between Cr and TNF-alpha (r=0.8969, P&lt;0.001); and negative correlation between Cr and BMD (r=0.5472, P&lt;0.001), and between Cr and 25(OH)D (r=0.4733, P&lt;0.001).	Creatinine	113-115	tumor necrosis factor	Homo sapiens	120-129
32362306-7	2019	MMP-3, MMP-7, TIMP-1, and PAPP-A correlated with serum creatinine.	Creatinine	55-65	matrix metallopeptidase 3	Homo sapiens	0-5
32362306-7	2019	MMP-3, MMP-7, TIMP-1, and PAPP-A correlated with serum creatinine.	Creatinine	55-65	TIMP metallopeptidase inhibitor 1	Homo sapiens	14-20
29799059-7	2019	Interestingly, the creatinine clearance rate was between 30 and 80 mL/min in 87 (87.9%) of the patients suggesting that S-1 dose modification should be considered.	Creatinine	19-29	proteasome 26S subunit, non-ATPase 1	Homo sapiens	120-123
31519530-9	2019	This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine).	Creatinine	85-95	interleukin 6	Homo sapiens	150-154
31332994-10	2019	Linear regression analysis revealed that, eGFR, CRP, thrombocytopenia, and serum creatinine were independently correlated with TGF-beta1 among lupus nephritis patients (P &lt; 0.001).	Creatinine	81-91	transforming growth factor beta 1	Homo sapiens	127-136
31230050-10	2019	Furthermore, when challenged with lethal doses of systemic LPS, pathologic abnormalities in renal structure, increased serum and kidney interleukin-1beta, increased serum creatinine, and animal death were observed in wild-type mice but prevented in caspase-11-/- mice.	Creatinine	171-181	toll-like receptor 4	Mus musculus	59-62
30571562-0	2019	Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus.	Creatinine	25-35	angiotensin I converting enzyme	Homo sapiens	51-80
30571562-1	2019	Discontinuation of angiotensin-converting enzyme (ACE) inhibitor is recommended if patients experience &gt;=30% acute increase in serum creatinine after starting this therapy.	Creatinine	136-146	angiotensin I converting enzyme	Homo sapiens	19-48
30571562-1	2019	Discontinuation of angiotensin-converting enzyme (ACE) inhibitor is recommended if patients experience &gt;=30% acute increase in serum creatinine after starting this therapy.	Creatinine	136-146	angiotensin I converting enzyme	Homo sapiens	50-53
30309264-8	2019	Copeptin remained as a predictor at discharge and after 3 months in the final multiple model (including: heart failure/age/creatinine clearance).	Creatinine	123-133	arginine vasopressin	Homo sapiens	0-8
31285802-10	2019	Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively).	Creatinine	6-16	C-X-C motif chemokine ligand 9	Homo sapiens	64-69
30785340-1	2019	Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine.	Creatinine	156-166	selenophosphate synthetase 1	Homo sapiens	24-27
30584253-10	2018	The combined set LMM showed that only CYP3A7 rs2257401 was associated with tacrolimus C0/D after adjusting for patient age, albumin, and creatinine.	Creatinine	137-147	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	38-44
30619076-3	2018	In this mini-review, we provide the main findings of metabolomics studies in ALS and discuss the most relevant therapeutics attempts that targeted some prominent alterations found in ALS, like glutamate excitotoxicity, oxidative stress, alterations in energetic metabolism, and creatinine levels.	Creatinine	278-288	superoxide dismutase 1	Homo sapiens	183-186
30545066-10	2018	The addition of baseline creatinine to  hs-cTnT improved the AUC to 0.87 (0.76-0.99), and addition of diabetes improved the AUC to 0.93 (0.88-0.99).	Creatinine	25-35	troponin T2, cardiac type	Homo sapiens	43-47
30348828-5	2018	Furthermore, the urine ADRP content significantly increased in DKD patients compared with the control, which positively correlated with abnormal lipid metabolism, serum creatinine, urine N-acetyl-beta-glucosaminidase (NAG), albumin excretion (albumin-to-creatinine ratio (ACR)), and tumor necrosis factor-alpha (TNF-alpha) expression.	Creatinine	169-179	perilipin 2	Homo sapiens	23-27
30450602-7	2018	IGFBP7 knockdown effectively alleviated the severity of the renal injury, evidenced by decreases in the urinary levels of creatinine, blood urea nitrogen, and albumin, cell apoptosis, and activation of ERK1/2 signaling in CLP mice.	Creatinine	122-132	insulin-like growth factor binding protein 7	Mus musculus	0-6
30546836-9	2018	Finally, the inhibition of HPSE in vivo almost restored renal function as measured by BUN, plasma creatinine and albuminuria.	Creatinine	98-108	heparanase	Mus musculus	27-31
30487748-9	2018	Analysis of primary outcomes showed that patients carrying MTOR c.1437CC and FOXP3 c.-23+2882CC genotypes had higher serum creatinine than non-carriers (p &lt; 0.05) at 1-year post-transplant.	Creatinine	123-133	mechanistic target of rapamycin kinase	Homo sapiens	59-63
30173364-6	2018	RESULTS: Using clinical-metabolomics models, we identified associations of decreased eGFR with body mass index (BMI), uric acid and C10:2 levels; albuminuria was associated to years of T2D duration, A1C, uric acid, creatinine, protein intake and serum C0, C10:2 and urinary C12:1 levels.	Creatinine	215-225	epidermal growth factor receptor	Homo sapiens	85-89
29391267-4	2018	We aimed to identify factors associated with response to treatment with terlipressin and albumin in patients with type 1 HRS (reduction in serum level of creatinine to below 1.5 mg/dL at the end of treatment) and factors associated with death within 90 days of HRS diagnosis (90-day mortality).	Creatinine	154-164	albumin	Homo sapiens	89-96
30766810-8	2018	There was a statistically significant positive correlation found between PTH and S. creatinine (P &lt;= 0.001; r = 0.596), whereas the statistically significant negative correlation found between PTH and eGFR (P &lt;= 0.001; r = -0.525).	Creatinine	84-94	parathyroid hormone	Homo sapiens	73-76
30279273-5	2018	RESULTS: Median urinary DKK3-to-creatinine concentration at baseline was significantly higher in patients with CKD than the general population sample (431 versus 33 pg/mg).	Creatinine	32-42	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	24-28
30279273-6	2018	In the CKD cohort, having a urinary DKK3-to-creatinine level &gt;4000 pg/mg was independently and significantly associated after multiple adjustments with mean annual decline in eGFR of 7.6% over 12 months.	Creatinine	44-54	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	36-40
30279273-6	2018	In the CKD cohort, having a urinary DKK3-to-creatinine level &gt;4000 pg/mg was independently and significantly associated after multiple adjustments with mean annual decline in eGFR of 7.6% over 12 months.	Creatinine	44-54	epidermal growth factor receptor	Homo sapiens	178-182
30279273-8	2018	Urinary DKK3-to-creatinine levels were related to the extent of tubulointerstitial fibrosis in kidney biopsies.	Creatinine	16-26	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	8-12
29926959-9	2019	RESULTS: Uric acid to creatinine ratio was significantly correlated with Crohn"s disease activity index (rho = 0.184, P = 0.002) and Harvey Bradshaw index (rho = 0.154, P = 0.010) and C-reactive protein (rho = 0.591, P &lt; 0.001) in CD group.	Creatinine	22-32	C-reactive protein	Homo sapiens	184-202
31117091-10	2019	Podocin and podocalyxin were negatively correlated with eGFR and positively correlated with urine protein to creatinine ratio in ADPKD patients.	Creatinine	109-119	NPHS2 stomatin family member, podocin	Homo sapiens	0-7
31117091-10	2019	Podocin and podocalyxin were negatively correlated with eGFR and positively correlated with urine protein to creatinine ratio in ADPKD patients.	Creatinine	109-119	podocalyxin like	Homo sapiens	12-23
29894413-9	2019	There was a significant improvement of urine protein to creatinine ratio from a mean +- SD of 8.6 +- 7.6 g/g before ACTH gel to 3.3 +- 2.3 g/g after the use of ACTH gel (P = 0.004).	Creatinine	56-66	proopiomelanocortin	Homo sapiens	160-164
30370838-7	2019	In affected dogs, significant upregulation of kidney miR-21 was first detected at the milestone corresponding with increased serum creatinine.	Creatinine	131-141	microRNA 21	Canis lupus familiaris	53-59
30370838-8	2019	Furthermore, miR-21 expression correlated significantly with urine protein: urine creatinine ratio, serum creatinine concentration, glomerular filtration rate, and histologic lesions (glomerular damage, tubular damage, chronic inflammation, and fibrosis).	Creatinine	82-92	microRNA 21	Canis lupus familiaris	13-19
30370838-8	2019	Furthermore, miR-21 expression correlated significantly with urine protein: urine creatinine ratio, serum creatinine concentration, glomerular filtration rate, and histologic lesions (glomerular damage, tubular damage, chronic inflammation, and fibrosis).	Creatinine	106-116	microRNA 21	Canis lupus familiaris	13-19
30692319-7	2018	The volume of the collected ascitic fluid was 7.0+-2.6 L, and the albumin(Alb)concentration in the reinfused ascitic fluid was 52.6+-31.4 g. Serum Alb level after KM-CART did not decrease from the pretreatment level, while serum creatinine(Cr)level decreased significantly.	Creatinine	229-239	albumin	Homo sapiens	147-150
29707997-9	2018	There was a significant positive correlation between creatinine and TNF-alpha when combining GI and GII while there were significant negative correlation between creatinine and other tissue markers in same groups.	Creatinine	53-63	tumor necrosis factor	Homo sapiens	68-77
29619870-7	2018	Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26-6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine.	Creatinine	215-225	epidermal growth factor receptor	Homo sapiens	20-24
29698843-0	2018	Creatinine downregulates TNF-alpha in macrophage and T cell lines.	Creatinine	0-10	tumor necrosis factor	Homo sapiens	25-34
30359254-9	2018	Several genes, including UMOD, SHROOM3 and ELMO1 have been strongly associated with renal diseases, and some of their traits, such as eGFR and serum creatinine.	Creatinine	149-159	shroom family member 3	Homo sapiens	31-38
30359254-9	2018	Several genes, including UMOD, SHROOM3 and ELMO1 have been strongly associated with renal diseases, and some of their traits, such as eGFR and serum creatinine.	Creatinine	149-159	engulfment and cell motility 1	Homo sapiens	43-48
30009473-12	2018	Delta PENK accelerates the detection of creatinine-blind AKI by 24 hours.	Creatinine	40-50	proenkephalin	Homo sapiens	6-10
29807686-8	2018	With increasing Sfrp5 tertiles, the patients had higher frequencies of hypertension, stage 4 or 5 CKD, and waist-to-hip ratio, incrementally lower eGFRs and serum hemoglobin levels, and higher levels of blood urine nitrogen (BUN), creatinine, and adiponectin.	Creatinine	231-241	secreted frizzled related protein 5	Homo sapiens	16-21
29807686-10	2018	Sfrp5 was also significantly positively related to BUN, creatinine, and adiponectin, and significantly negatively related to eGFR and hemoglobin.	Creatinine	56-66	secreted frizzled related protein 5	Homo sapiens	0-5
29807686-12	2018	In addition, Sfrp5 was significantly positively related to BUN, creatinine, and adiponectin, and significantly negatively related to eGFR and hemoglobin in patients >65 years old.	Creatinine	64-74	secreted frizzled related protein 5	Homo sapiens	13-18
30214507-6	2018	Blood sample analysis revealed that B-type natriuretic peptide (BNP), troponin T, C-reactive protein (CRP), creatinine and phosphorus concentrations were increased in the PTH-untreated CM group compared with that in the control group, whereas PTH and calcium concentrations were decreased.	Creatinine	108-118	parathyroid hormone	Rattus norvegicus	171-174
30214507-7	2018	Administration of PTH dose-dependently decreased BNP, CRP, creatinine and phosphorus levels, and increased PTH and calcium levels.	Creatinine	59-69	parathyroid hormone	Rattus norvegicus	18-21
30016681-6	2018	DIO mice receiving Stx2 injections lost more body weight, and had significantly higher (p &lt; 0.001) BUN, serum creatinine, and neutrophil counts compared to WT mice or DIO mice receiving saline injections.	Creatinine	113-123	syntaxin 2	Mus musculus	19-23
30252923-3	2018	eGFR was calculated by means of the CKD-EPI formulas (CKD-EPI-creatinine: eGFRcrea; CKD-EPI-cystatin C: eGFRcyst).	Creatinine	62-72	epidermal growth factor receptor	Homo sapiens	0-4
30267533-6	2018	RESULTS Serum prolactin concentrations were significantly higher in elderly people ($65 vs. &gt;65) and in men (70.65+-58.02 vs. 150.82+-114.05 mIU/L), as well as in patients with lower renal function (156.70+-127.23 vs. 72.53+-37.25 mIU/L, the bottom vs. top quartile of creatinine clearance), higher serum homocysteine and TSH concentrations, and in those who used NSAID and statins.	Creatinine	272-282	prolactin	Homo sapiens	14-23
30267533-7	2018	Parameters indicating chronic inflammation (CRP) and renal function decline (creatinine clearance) were significantly and independently correlated with increased serum prolactin concentrations in multiple regression analysis.	Creatinine	77-87	prolactin	Homo sapiens	168-177
30268122-7	2018	In contrast, platelet count and high-sensitivity C-reactive protein were only associated with peak thrombin generation potential, and body mass index and serum creatinine were only associated with AUC of thrombin generation potential after adjustment for covariates by multivariate linear regression analyses (all p &lt; 0.05).	Creatinine	160-170	coagulation factor II, thrombin	Homo sapiens	204-212
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Creatinine	253-263	nitric oxide synthase 2	Rattus norvegicus	174-178
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Creatinine	265-269	nitric oxide synthase 2	Rattus norvegicus	174-178
30205620-7	2018	PE concentrations of ENA-78/VEGF/IL-8/MDC/PCS/indoxyl sulphate correlate with serum creatinine concentrations.	Creatinine	84-94	vascular endothelial growth factor A	Homo sapiens	28-32
30205620-7	2018	PE concentrations of ENA-78/VEGF/IL-8/MDC/PCS/indoxyl sulphate correlate with serum creatinine concentrations.	Creatinine	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
30106306-4	2018	The reaction was found to begin with the C(sp2)-H oxidative addition of the pyridine ligand to give the Ir(III) hydride intermediate, from which the isomerization further takes place via the insertion/elimination pathway.	Creatinine	112-119	Sp2 transcription factor	Homo sapiens	41-46
29790392-10	2018	Compared with WT mice, IL-1R1 KO mice had attenuated AKI as measured by serum creatinine and BUN, renal NGAL mRNA levels, and blinded histological analysis of kidney pathology.	Creatinine	78-88	interleukin 1 receptor, type I	Mus musculus	23-29
29199440-3	2018	Results The urinary adiponectin concentrations in patients with diabetes (3.3 +- 10.7 ng/mg creatinine) were significantly higher than those in obese subjects (0.54 +- 0.44; P &lt; 0.01) and healthy subjects (0.46 +- 0.42; P &lt; 0.001).	Creatinine	92-102	adiponectin, C1Q and collagen domain containing	Homo sapiens	20-31
30130521-7	2018	Also, significant negative correlation was found between paraoxonase activity of PON1 in serum and creatinine concentration (rho=-0.373, p&lt;0.01).	Creatinine	99-109	paraoxonase 1	Homo sapiens	81-85
32055559-1	2018	Adding to the complexity of caring for critically ill patients is the fact that many of them have a creatinine clearance that exceeds 130 mL/min/1.73 m2.	Creatinine	100-110	CD59 molecule (CD59 blood group)	Homo sapiens	141-146
30143691-7	2018	The addition of urinary cMet to serum creatinine and proteinuria provided the highest net reclassification improvement.	Creatinine	38-48	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	24-28
30186149-6	2018	BCSFB disruption to creatinine, a larger molecule governed by active transport, had a full model r2 = 0.78, and large standardized dominance weights for monocyte inhibitor protein-1b in CSF and tumor necrosis factor-alpha in serum.	Creatinine	20-30	tumor necrosis factor	Homo sapiens	194-221
29850782-0	2018	Association Between Change in Central Nocturnal Blood Pressure and Urine Albumin-Creatinine Ratio by a Valsartan/Amlodipine Combination: A CPET Study.	Creatinine	81-91	albumin	Homo sapiens	73-80
29850782-1	2018	BACKGROUND: We aimed to assess the association of changes in brachial or central nocturnal systolic blood pressure (SBP) with change in urine albumin-creatinine ratio (UACR) by a valsartan/amlodipine combination (80/5 mg) therapy in hypertensive patients.	Creatinine	150-160	albumin	Homo sapiens	142-149
30026130-5	2018	Patients with a urinary L-FABP level above the upper normal limit (8.4 microg/g creatinine) (n = 49; 35.5%) were more likely than those with a urinary L-FABP level within normal limits (n = 89; 64.5%) to develop WRF (n = 26 [53.1%] vs n = 11 [12.4%]; P &lt; .001).	Creatinine	80-90	fatty acid binding protein 1	Homo sapiens	24-30
30030497-5	2018	Using a mouse model of angiotensin II (Ang II)-induced renal damage, we demonstrate that PI3Kgamma inhibitor AS605240 effectively mitigates Ang II-induced increases in serum creatinine and blood urea nitrogen, renal interstitial collagen deposition, the accumulation of ECM proteins and the expression of alpha-Sma and fibrosis-related genes in vivo.	Creatinine	174-184	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	140-146
29858267-7	2018	Patients with D-ATIN/TINU carrying HLA-DQA1*0104/DQB1*0503/DRB1*1405 had higher peak serum creatinine and more severe renal tubulointerstitial inflammatory impairment.	Creatinine	91-101	major histocompatibility complex, class II, DR beta 1	Homo sapiens	59-63
30377595-9	2018	Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p&lt;0.001).	Creatinine	30-40	C-C motif chemokine ligand 4	Rattus norvegicus	9-13
30377595-9	2018	Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p&lt;0.001).	Creatinine	56-66	C-C motif chemokine ligand 4	Rattus norvegicus	9-13
29504280-7	2018	SUA/creatinine also positively correlates with insulin resistance (HOMA-IR: r = 0.161, P &lt; 0.001).	Creatinine	4-14	insulin	Homo sapiens	47-54
29684255-8	2018	Fold changes in the gene expression of ET-1, interleukin (IL) 18, and tumor necrosis factor alpha (TNF-alpha) were associated with creatinine peak value.	Creatinine	131-141	tumor necrosis factor	Homo sapiens	70-97
29684255-8	2018	Fold changes in the gene expression of ET-1, interleukin (IL) 18, and tumor necrosis factor alpha (TNF-alpha) were associated with creatinine peak value.	Creatinine	131-141	tumor necrosis factor	Homo sapiens	99-108
29988557-7	2018	Compared with sham-treated animals, mice subjected to Stx2 developed profound weight loss, kidney dysfunction (elevation of plasma urea, creatinine, and neutrophil gelatinase-associated lipocalin), kidney injury (tubular injury and loss of endothelial cells), thrombotic microangiopathy (arteriolar microthrombi), and hemolysis (elevation of plasma bilirubin, lactate dehydrogenase, and free hemoglobin).	Creatinine	137-147	syntaxin 2	Mus musculus	54-58
30323640-1	2018	Background: Several clinical studies have shown increased level of urinary TGF-beta1 in diabetic nephropathy patients and its correlation with urine albumin-to-creatinine ratio (UACR), but other studies showed different results.	Creatinine	160-170	transforming growth factor beta 1	Homo sapiens	75-84
28703928-7	2018	RESULTS: We have found a peak of regulatory cytokines in RTR with low creatinine levels as well as a peak of IL-6 pro-inflammatory cytokine in patients with high creatinine levels.	Creatinine	162-172	interleukin 6	Homo sapiens	109-113
30167324-2	2018	Methods: We did a retrospective cohort study using Chinese elder patients with high cardiovascular risks (n = 1474) to identify the association of albumin-to-creatinine ratio (ACR) and the incidence of MACE and all-cause mortality.	Creatinine	158-168	albumin	Homo sapiens	147-154
28718073-9	2018	Both OC3 and placebo groups demonstrated a decrease in Uox/urinary creatinine ratio, but the difference was not statistically significant.	Creatinine	67-77	one cut homeobox 3	Homo sapiens	5-8
31431971-11	2018	CYC (within 100 mg of the target dose calculated for age, weight and creatinine) was administered in 58% of patients.	Creatinine	69-79	cytochrome c, somatic	Homo sapiens	0-3
30093945-9	2018	In kidney, the expressions of tubular injury markers of kidney injury molecule-1 (KIM-1) and gelatinase-associated lipocalin (NGAL) were further upregulated along with higher levels of blood urea nitrogen (BUN), creatinine (Cr), and MDA in celastrol-treated mice.	Creatinine	212-222	hepatitis A virus cellular receptor 1	Mus musculus	56-80
30093945-9	2018	In kidney, the expressions of tubular injury markers of kidney injury molecule-1 (KIM-1) and gelatinase-associated lipocalin (NGAL) were further upregulated along with higher levels of blood urea nitrogen (BUN), creatinine (Cr), and MDA in celastrol-treated mice.	Creatinine	212-222	hepatitis A virus cellular receptor 1	Mus musculus	82-87
30093945-9	2018	In kidney, the expressions of tubular injury markers of kidney injury molecule-1 (KIM-1) and gelatinase-associated lipocalin (NGAL) were further upregulated along with higher levels of blood urea nitrogen (BUN), creatinine (Cr), and MDA in celastrol-treated mice.	Creatinine	224-226	hepatitis A virus cellular receptor 1	Mus musculus	56-80
30093945-9	2018	In kidney, the expressions of tubular injury markers of kidney injury molecule-1 (KIM-1) and gelatinase-associated lipocalin (NGAL) were further upregulated along with higher levels of blood urea nitrogen (BUN), creatinine (Cr), and MDA in celastrol-treated mice.	Creatinine	224-226	hepatitis A virus cellular receptor 1	Mus musculus	82-87
30123048-8	2018	U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol).	Creatinine	30-40	orosomucoid 1	Homo sapiens	2-5
30123048-8	2018	U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol).	Creatinine	30-40	orosomucoid 1	Homo sapiens	44-47
30342848-8	2018	RESULTS: CCl4 caused a significant elevation of liver enzymes, lactic acid dehydrogenase, blood glucose, uric acid, blood urea and serum creatinine as compared to the control group.	Creatinine	137-147	C-C motif chemokine ligand 4	Rattus norvegicus	9-13
29803073-5	2018	Exposure to Cis and IRR significantly induced renal damage manifested by a significant increase in levels of urea and creatinine.	Creatinine	118-128	insulin receptor-related receptor	Mus musculus	20-23
29915248-0	2018	Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1.	Creatinine	58-68	solute carrier family 47 member 1	Rattus norvegicus	72-77
29915248-1	2018	Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1).	Creatinine	0-10	solute carrier family 47 member 1	Rattus norvegicus	108-139
29915248-1	2018	Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1).	Creatinine	0-10	solute carrier family 47 member 1	Rattus norvegicus	141-146
29345404-1	2018	AIMS: To assess variability in systolic blood pressure (SBP) and albuminuria (urinary albumin creatinine ratio [UACR]) responses in patients with type 2 diabetes mellitus initiating renin angiotensin aldosterone system (RAAS) inhibition, and to assess the association of response variability with cardiovascular outcomes.	Creatinine	94-104	renin	Homo sapiens	182-187
29915248-3	2018	In the present work, we examined the inhibitory potency of TKIs, including crizotinib, on MATE1-mediated transport of creatinine.	Creatinine	118-128	solute carrier family 47 member 1	Rattus norvegicus	90-95
29915248-5	2018	Crizotinib inhibited [14C]creatinine uptake by MATE1-overexpressing cells, and the inhibitory effect increased with incubation time, being greater in the case of pre-incubation or combined pre-incubation/co-incubation (pre/co-incubation) than in the case of co-incubation alone.	Creatinine	26-36	solute carrier family 47 member 1	Rattus norvegicus	47-52
29915248-8	2018	Gefitinib, imatinib, pazopanib, sorafenib, and sunitinib also inhibited MATE1-mediated creatinine uptake.	Creatinine	87-97	solute carrier family 47 member 1	Rattus norvegicus	72-77
29998125-5	2018	After 3 months of AST-120 therapy, eGFR was increased to 17.8 mL/min/1.73 m2 (serum creatinine of 2.90-2.72 mg/dL).	Creatinine	84-94	epidermal growth factor receptor	Homo sapiens	35-39
30074212-9	2018	The estimated glomerular filtration rate was positively correlated with the TGF-beta1 level, and the serum creatinine level was negatively correlated with the TGF-beta1 level.	Creatinine	107-117	transforming growth factor beta 1	Homo sapiens	159-168
29728506-7	2018	Compared with SLE mice, AIDG23S MRL/lpr mice exhibited decreased proteinuria, blood urea nitrogen, and creatinine, indicating that the loss of SHM contributed to the recovery of renal functions.	Creatinine	103-113	Fas (TNF receptor superfamily member 6)	Mus musculus	36-39
29633144-6	2018	RESULTS: CgA correlated positively with serum BUN, creatinine, alpha2-globulin, red-cell distribution width, erythrocyte sedimentation rate, plasma glucose and correlated inversely with hemoglobin, thrombocytes and serum albumin.	Creatinine	51-61	chromogranin A	Homo sapiens	9-12
29656357-6	2018	The concentration of OH-PCBs in PCB transport workers" urine (0.55~11 mug/g creatinine (Cre)) was higher than in PCB researchers" urine (&lt; 0.20 mug/g Cre).	Creatinine	76-86	pyruvate carboxylase	Homo sapiens	24-27
29656357-6	2018	The concentration of OH-PCBs in PCB transport workers" urine (0.55~11 mug/g creatinine (Cre)) was higher than in PCB researchers" urine (&lt; 0.20 mug/g Cre).	Creatinine	76-86	pyruvate carboxylase	Homo sapiens	32-35
29656357-6	2018	The concentration of OH-PCBs in PCB transport workers" urine (0.55~11 mug/g creatinine (Cre)) was higher than in PCB researchers" urine (&lt; 0.20 mug/g Cre).	Creatinine	88-91	pyruvate carboxylase	Homo sapiens	24-27
29656357-6	2018	The concentration of OH-PCBs in PCB transport workers" urine (0.55~11 mug/g creatinine (Cre)) was higher than in PCB researchers" urine (&lt; 0.20 mug/g Cre).	Creatinine	88-91	pyruvate carboxylase	Homo sapiens	32-35
29888290-7	2018	Significant positive correlations of VDBP clearance ratio were found with age, WC, SBP, DBP, TG, glucose, HbA1c, urine VDBP, urine microalbumin, and urine microalbumin/creatinine, and a significant negative correlation was found with the steady-state estimate of beta cell function (B%).	Creatinine	168-178	D-box binding PAR bZIP transcription factor	Homo sapiens	38-41
29452170-8	2018	Furthermore, Sirt1 expression was negatively correlated with the 24-h urinary protein excretion and serum creatinine levels, Banff score sums, mononuclear cell infiltration and IF severity, and TGF-beta1, MCP-1 and ICAM-1 expression levels.	Creatinine	106-116	sirtuin 1	Rattus norvegicus	13-18
29669385-5	2018	The overexpression of apoM improved the survival rate and ameliorated the elevated plasma alanine aminotransferase (ALT) and creatinine levels, while the knockout or knockdown of apoM deteriorated these parameters in mice treated with LPS.	Creatinine	125-135	apolipoprotein M	Mus musculus	22-26
29405987-5	2018	Creatinine elicited visibly-discernable color changes of the cc-AgNPs colloids in a concentration-dependent manner up to 10 muM.	Creatinine	0-10	latexin	Homo sapiens	124-127
29405987-8	2018	The cc-AgNP sensor exhibited a linear correlation between the A670/A403 extinction ratio and creatinine concentration range of 0-4.2 muM in aqueous solutions (R2 = 0.996), and a low detection limit of 53.4 nM.	Creatinine	93-103	latexin	Homo sapiens	133-136
28990417-11	2018	The relation between CD4 counts and creatinine was statistically significant, p &lt; .01, as was the association between CD4 counts and BMI, p &lt; .01.	Creatinine	36-46	CD4 molecule	Homo sapiens	21-24
29476732-1	2018	BACKGROUND: Beta trace protein (BTP) is a novel renal biomarker that has emerged as potential alternative or addition to serum creatinine (Scr) and serum cystatin C (ScysC).	Creatinine	127-137	prostaglandin D2 synthase	Homo sapiens	12-30
29526051-4	2018	Graft function, assessed using the creatinine reduction ratio on postoperative day 2 (CCR2), was evaluated by multivariable linear regression analysis and in a propensity-matched cohort.	Creatinine	35-45	C-C motif chemokine receptor 2	Homo sapiens	86-90
29526625-9	2018	Greater yearly eGFR decline was associated with higher albumin/creatinine ratio at follow-up, lower age, and baseline SBP not being at target (p = 0.005, with an R2 of 0.197).	Creatinine	63-73	epidermal growth factor receptor	Homo sapiens	15-19
29398132-2	2018	eGFR slopes estimated from serial measurements of serum creatinine during 5-12 years of follow-up were used to define early renal decline.	Creatinine	56-66	epidermal growth factor receptor	Homo sapiens	0-4
29572281-8	2018	The mean serum creatinine concentration was 0.56 mg/dL at the onset of weakness in patients with SBMA compared to 0.88 +- 0.10 mg/dL on final evaluation in healthy controls.	Creatinine	15-25	androgen receptor	Homo sapiens	97-101
29572281-11	2018	CONCLUSIONS: Our findings suggest that serum creatinine begins to decrease before the onset of clinical symptoms and is a biomarker for disease progression and the efficacy of therapeutics in preclinical SBMA.	Creatinine	45-55	androgen receptor	Homo sapiens	204-208
29653513-14	2018	The BTP/Cr ratio was higher in those with more advanced cirrhosis as compared to those with less severe cirrhosis (1.20 vs 1.03, p &lt; 0.01).	Creatinine	8-10	prostaglandin D2 synthase	Homo sapiens	4-7
29796221-4	2018	Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P&lt;=0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman"s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups.	Creatinine	60-70	C-C motif chemokine ligand 4	Rattus norvegicus	16-20
29881418-8	2018	BUN (blood urea nitrogen) and creatinine (Cr) concentrations were significantly increased in BRI+V group 24 h after reperfusion.	Creatinine	30-40	integral membrane protein 2B	Rattus norvegicus	93-96
29881418-8	2018	BUN (blood urea nitrogen) and creatinine (Cr) concentrations were significantly increased in BRI+V group 24 h after reperfusion.	Creatinine	42-44	integral membrane protein 2B	Rattus norvegicus	93-96
29371417-6	2018	Gene delivery of IDH2 before injury attenuated the injury-induced rise in serum creatinine (P&lt;0.05) observed in controls and increased the mitochondria membrane potential (P&lt;0.05), maximal respiratory capacity (P&lt;0.05), and intracellular ATP levels (P&lt;0.05) above those in controls.	Creatinine	80-90	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	17-21
29332011-2	2018	This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular filtration rate (eGFR) of 45-59 mL/min/1.73 m2 (CKD stage 3a).	Creatinine	83-93	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
29527508-5	2018	However, serum copeptin is strongly correlated with creatinine, and its additional value as a prognostic biomarker over estimated glomerular filtration rate and TKV is not certain.	Creatinine	52-62	arginine vasopressin	Homo sapiens	15-23
29782204-6	2018	Carriers of the PON1-192R allele had significantly lower Hcy-thiolactone/creatinine levels than individuals carrying the PON1-192Q allele.	Creatinine	73-83	paraoxonase 1	Homo sapiens	16-20
29782204-7	2018	Individuals with low serum PON1 paraoxonase activity had significantly higher Hcy-thiolactone/creatinine levels compared with individuals with high paraoxonase activity.	Creatinine	94-104	paraoxonase 1	Homo sapiens	27-31
29596409-9	2018	IFN-gamma/IL-10 ratio and CRP values marked the immune biosignature of vivax malaria patients, and could distinguish subjects with elevated creatinine levels who did not survive from those who did.	Creatinine	140-150	interferon gamma	Homo sapiens	0-9
29331592-3	2018	GFR was measured by 51Cr-EDTA and estimated (eGFR) by the following equations using creatinine, cysC or both markers: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Caucasian Asian Pediatrics and Adults (CAPA), CKD-EPI creatinine-cystatin C (CKDEPI-CC), and CKD-EPI cystatin C (CKDEPIcysC).	Creatinine	84-94	epidermal growth factor receptor	Homo sapiens	45-49
29287218-11	2018	Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol.	Creatinine	178-188	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
29390980-14	2018	All creatinine-based eGFR equations overestimated GFR (p &lt; 0.01 for each creatinine based eGFR equation).	Creatinine	4-14	epidermal growth factor receptor	Homo sapiens	21-25
29390980-14	2018	All creatinine-based eGFR equations overestimated GFR (p &lt; 0.01 for each creatinine based eGFR equation).	Creatinine	76-86	epidermal growth factor receptor	Homo sapiens	93-97
29079359-10	2018	In multivariate models, race time, serum sodium, creatinine and cortisol were significant predictors of copeptin levels.	Creatinine	49-59	arginine vasopressin	Homo sapiens	104-112
28939943-2	2018	Childhood CKD is predominantly defined by a decrease in glomerular filtration rate, estimated (eGFR) by a single serum measurement of endogenous biomarkers, e.g. creatinine.	Creatinine	162-172	epidermal growth factor receptor	Homo sapiens	95-99
28939943-6	2018	RESULTS: Updated Schwartz eGFR was correlated reasonably well with concentrations of creatinine (r = -0.98), urea (rs = -0.84), SDMA (r = -0.82) and middle molecules CfD and beta2M (both rs = -0.90).	Creatinine	85-95	epidermal growth factor receptor	Homo sapiens	26-30
29367621-12	2018	OPTN expression also negatively correlated with serum creatinine levels, and positively correlated with eGFR.	Creatinine	54-64	optineurin	Mus musculus	0-4
29310594-11	2018	Compared with controls, the median (inter-quartile) LL-37 level in plasma [2.100 (1.700-2.700) vs. 1.800 (1.000-2.200) ng/ml, P = 0.002] and in urine [0.900 (0.300-1.600) vs. 0.000 (0.000-1.000) ng/mg creatinine, P &lt; 0.001] was significantly higher in cases.	Creatinine	201-211	cathelicidin antimicrobial peptide	Homo sapiens	52-57
29920491-7	2018	The lack of CD117 expression was associated with elevated creatinine levels (p = 0.037).	Creatinine	58-68	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	12-17
29782204-5	2018	Here we show that the PON1-192 genotype, which affects the enzymatic activity of the PON1 protein, also affected urinary Hcy-thiolactone levels, normalized to creatinine.	Creatinine	159-169	paraoxonase 1	Homo sapiens	22-26
29782204-5	2018	Here we show that the PON1-192 genotype, which affects the enzymatic activity of the PON1 protein, also affected urinary Hcy-thiolactone levels, normalized to creatinine.	Creatinine	159-169	paraoxonase 1	Homo sapiens	85-89
29661427-9	2018	Pretreatment, intra-treatment, and post-treatment creatinine clearances were 61.4, 60.6, and 60.7 mL/min/1.73 m2, respectively (not significant [NS]).	Creatinine	50-60	CD59 molecule (CD59 blood group)	Homo sapiens	101-106
29543590-0	2018	Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity.	Creatinine	36-46	insulin	Homo sapiens	58-65
29657937-9	2018	The creatinine clearance (insignificantly) and urine flow (significantly; P &lt; 0.05) were decreased in both non-RDN and RDN male and female rats treated with Ang II.	Creatinine	4-14	angiotensinogen	Rattus norvegicus	160-166
29632491-6	2018	Pharmacological inhibition of HDAC6 by 23BB pretreatment significantly reduced serum creatinine and serum blood urea nitrogen (BUN) levels as well as attenuated renal tubular damage in GL-injured kidneys.	Creatinine	85-95	histone deacetylase 6	Mus musculus	30-35
29540159-6	2018	For each patient, hemato-chemical data have been retrieved, including the uric acid level and the creatinine-based eGFR.	Creatinine	98-108	epidermal growth factor receptor	Homo sapiens	115-119
29167164-6	2018	ANG II increased the mean arterial pressure (112 +- 5 vs. 145 +- 5 mmHg; P &lt; 0.01) and excretion of 8-isoprostane F2alpha (2.8 +- 0.3 vs. 3.8 +- 0.3 ng/mg creatinine; P &lt; 0.05) at 12-14 days.	Creatinine	158-168	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
29459508-7	2018	Plasma levels of creatinine and urea increased significantly in CCl4 control, while creatinine clearance was reduced significantly in the same group.	Creatinine	17-27	C-C motif chemokine ligand 4	Rattus norvegicus	64-68
28978530-4	2018	The VEGF-A concentration correlated with the dialysate-to-plasma ratio of creatinine (D/P Cr) ( P &lt; 0.001) and TGF-beta1 ( P &lt; 0.001) in human PD effluent.	Creatinine	74-84	vascular endothelial growth factor A	Homo sapiens	4-10
28962537-13	2018	Dose reductions of ~30% for creatinine clearance &lt;=30 mL/min/1.73 m2 are required.	Creatinine	28-38	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
29211853-4	2018	Genetic deletion of Nrf2 or pharmacological inhibition of Nrf2 in Akita mice attenuated hypertension, renal injury, tubulointerstitial fibrosis, and the urinary albumin/creatinine ratio.	Creatinine	169-179	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-24
29211853-4	2018	Genetic deletion of Nrf2 or pharmacological inhibition of Nrf2 in Akita mice attenuated hypertension, renal injury, tubulointerstitial fibrosis, and the urinary albumin/creatinine ratio.	Creatinine	169-179	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
28456135-7	2018	Baseline serum creatinine, new bacterial infection and new acute kidney injury during hospitalization, maximum rising rates of CLIF-C ACLF score, and Model for End-stage Liver Disease score were independent predictors of EASL-CLIF ACLF after enrollment.	Creatinine	15-25	aryl hydrocarbon receptor nuclear translocator like 2	Homo sapiens	226-230
29303781-9	2018	CONCLUSIONS: Our results suggest that sodium intake, as estimated by the urinary sodium to urinary creatinine ratio, may be independently associated with insulin resistance in children and adolescents.	Creatinine	99-109	insulin	Homo sapiens	154-161
29340241-7	2018	Binary logistic regression analysis for factors including age, BMI, creatinine, hs-CRP, smoking, steroid use, and forced expiratory volume in one second (FEV1) revealed that an hs-CRP level &gt;=5 and decreased creatinine level were independent risk factors for osteoporosis in COPD patients.	Creatinine	68-78	C-reactive protein	Homo sapiens	180-183
29340241-7	2018	Binary logistic regression analysis for factors including age, BMI, creatinine, hs-CRP, smoking, steroid use, and forced expiratory volume in one second (FEV1) revealed that an hs-CRP level &gt;=5 and decreased creatinine level were independent risk factors for osteoporosis in COPD patients.	Creatinine	211-221	C-reactive protein	Homo sapiens	180-183
29672317-8	2018	In multivariate analysis, paricalcitol and dialysate/plasma ratio of creatinine (D/P creatinine) were independently related to PPL (OR 4.270 [1.437-12.684], p = 0.009 and OR 0.205 [0.064-0.659], p = 0.008, respectively), adjusted for diabetes.	Creatinine	69-79	periplakin	Homo sapiens	127-130
29672317-8	2018	In multivariate analysis, paricalcitol and dialysate/plasma ratio of creatinine (D/P creatinine) were independently related to PPL (OR 4.270 [1.437-12.684], p = 0.009 and OR 0.205 [0.064-0.659], p = 0.008, respectively), adjusted for diabetes.	Creatinine	85-95	periplakin	Homo sapiens	127-130
29672317-9	2018	CONCLUSION: Paricalcitol and D/P creatinine were independently related to PPL.	Creatinine	33-43	periplakin	Homo sapiens	74-77
29421771-11	2018	Furthermore, the reciprocal concentrations of BTP was associated with the reciprocal concentrations of serum creatinine level (r = 0.365, P = .009).	Creatinine	109-119	prostaglandin D2 synthase	Homo sapiens	46-49
28729031-5	2018	Renal dysfunction (elevated serum creatinine and blood urea nitrogen) and glomerular/tubular lesions were observed in these Uox-knockout mice.	Creatinine	34-44	urate oxidase	Mus musculus	124-127
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	Creatinine	179-189	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	Creatinine	179-189	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	44-49
29794446-9	2018	Both ACE inhibitors and ARBs reduced the risk of doubling of the serum creatinine level (0.60, 0.39-0.91 for ACE inhibitors; 0.75, 0.64-0.88 for ARBs), and subgroup analyses for patients with macroalbuminuria or microalbuminuria showed similar results.	Creatinine	71-81	angiotensin I converting enzyme	Homo sapiens	5-8
29794446-9	2018	Both ACE inhibitors and ARBs reduced the risk of doubling of the serum creatinine level (0.60, 0.39-0.91 for ACE inhibitors; 0.75, 0.64-0.88 for ARBs), and subgroup analyses for patients with macroalbuminuria or microalbuminuria showed similar results.	Creatinine	71-81	angiotensin I converting enzyme	Homo sapiens	109-112
29268263-8	2018	RESULTS: Low PGC1alpha expression was associated with a significantly longer time on dialysis after transplant (median of 35.5 vs. 16 days, p &lt; 0.05) and a significantly higher serum creatinine (sCr) at 4 weeks after transplantation among those who discontinued dialysis (5 vs. 1.65 mg/dL, p &lt; 0.0001).	Creatinine	186-196	PPARG coactivator 1 alpha	Homo sapiens	13-22
29391892-9	2018	Alterations in creatinine concentrations (post-/pre-chemotherapy) due to chemotherapy were higher in patients with high levels of PTH regardless of Mg supplementation (P&lt;0.01).	Creatinine	15-25	parathyroid hormone	Homo sapiens	130-133
29743906-7	2018	CIN-AKI, diagnosed by the modified Schwartz formula, occurred in 16 (32%) patients after 24 h and in 8 (16%) after 48 h. Subsequent analysis showed that serum creatinine significantly rose in the first 2 h of the study with simultaneous reduction in the eGFR.	Creatinine	159-169	epidermal growth factor receptor	Homo sapiens	254-258
29390596-6	2017	Results: CKDu patients had significantly elevated urinarylevels of fibrinogen (198.2 ng/mg creatinine p&lt;0.001),clusterin (3479 ng/mg creatinine p&lt;0.001), cystatin-C(5124.8 ng/mg creatinine p&lt;0.001) and beta2-microglobulin(9913.4 ng/mg creatinine p&lt;0.001) compared to the controlgroups.	Creatinine	91-101	fibrinogen beta chain	Homo sapiens	67-77
29333147-1	2017	Creatinine-based glomerular filtration rate estimation (eGFRcr) has been improved and refined since the 1970s through both the Modification of Diet in Renal Disease (MDRD) Study equation in 1999 and the CKD Epidemiology Collaboration (CKD-EPI) equation in 2009, with current clinical practice dependent primarily on eGFR for accurate assessment of GFR.	Creatinine	0-10	epidermal growth factor receptor	Homo sapiens	56-60
28903970-5	2017	RESULTS: Median (interquartile range) urinary fibrinogen-to-creatinine ratio was 536 (191-1461) ng/mg for patients with CKD, significantly higher than 2 (2-3) ng/mg for healthy controls (P&lt;0.001).	Creatinine	60-70	fibrinogen beta chain	Homo sapiens	46-56
28903970-8	2017	Higher urinary fibrinogen level was associated with increased risk of ESRD (hazard ratio, 2.12; 95% confidence interval, 1.31 to 3.26) per log10 higher urinary fibrinogen-to-creatinine ratio (P=0.003) adjusting for age, sex, BP, urine protein, disease type, eGFR, and interstitial fibrosis and tubular atrophy.	Creatinine	174-184	fibrinogen beta chain	Homo sapiens	15-25
28903970-8	2017	Higher urinary fibrinogen level was associated with increased risk of ESRD (hazard ratio, 2.12; 95% confidence interval, 1.31 to 3.26) per log10 higher urinary fibrinogen-to-creatinine ratio (P=0.003) adjusting for age, sex, BP, urine protein, disease type, eGFR, and interstitial fibrosis and tubular atrophy.	Creatinine	174-184	fibrinogen beta chain	Homo sapiens	160-170
29216208-3	2017	Baseline eGFR was defined from the last serum creatinine measurement before study entry.	Creatinine	46-56	epidermal growth factor receptor	Homo sapiens	9-13
28847893-5	2017	To predict prolongation, PlGF showed the highest incremental value (R2=0.72) on top of traditional predictors (gestational age at inclusion, diastolic blood pressure, proteinuria, creatinine, uric acid, alanine transaminase, lactate dehydrogenase, and platelets) compared with R2=0.53 for the traditional predictors only.	Creatinine	180-190	placental growth factor	Homo sapiens	25-29
27792213-14	2017	Insulin-treated patients had lower hemoglobin, higher creatinine and discharged B-type natriuretic peptide (BNP) levels (816.6 [289.2-1805.8] vs. 613.3 [205.6-1110.8]; P=0.02).	Creatinine	54-64	insulin	Homo sapiens	0-7
27792213-17	2017	After multivariate adjustment accounting for hemoglobin, creatinine and discharge BNP, HR for 1-, 2-, 3-, and 5-year all-cause death in insulin-treated patients were 1.48 (0.62-3.54); P=0.38, 1.11 (0.55-2.25); P=0.77, 1.08 (0.56-2.08); P=0.28 and 1.24 (0.70-2.19); P=0.46, respectively.	Creatinine	57-67	insulin	Homo sapiens	136-143
29218078-6	2017	By 27 h after IR, creatinine level/MCP-1 + area was significantly higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1 (all P&lt;0.0001).	Creatinine	18-28	mast cell protease 1-like 1	Rattus norvegicus	35-40
29226648-8	2017	A statistically significant positive correlation was found between fibulin 1 and creatinine (r = 0.377, p = 0.001).	Creatinine	81-91	fibulin 1	Homo sapiens	67-76
28102614-11	2017	Patients with CD4+ CD28null T-cells &gt;=10% had higher HbA1c, urinary albumin creatinine ratio, aortic stiffness, and CIMT.	Creatinine	79-89	CD4 molecule	Homo sapiens	14-17
29105594-1	2017	BACKGROUND: In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, &gt;=60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed the growth in total kidney volume and the decline in the estimated glomerular filtration rate (GFR) but also caused more elevations in aminotransferase and bilirubin levels.	Creatinine	125-135	arginine vasopressin receptor 2	Homo sapiens	175-198
29163550-4	2017	AAT showed negative correlation with red blood cells, hemoglobin (Hb), hematocrit, high-density lipoprotein cholesterol, urea, creatinine, and albumin and was positively correlated with mean corpuscular Hb concentration, white blood cells, neutrophils, Hb S, bilirubin, lactate dehydrogenase, ferritin, and C-reactive protein.	Creatinine	127-137	serpin family A member 1	Homo sapiens	0-3
27832731-9	2017	The creatinine clearance of 77.3% of patients was below 60 mL/min/1.73 m2, 8.4% had proteinuria, and 2.5% had isolated microscopic hematuria.	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
28494217-5	2017	The IL-8 concentration determined on day 1 was significantly negatively correlated with creatinine clearance early after renal transplantation (on days 1, 7, 14 and 30), as well as during long-term observations.	Creatinine	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
28787643-10	2017	At 3year follow-up, elevated cTnT was related to attenuated urine norepinephrine:creatinine ratio in Blacks [OR 1.46 (95% CI 1.01-2.10); P=0.04].	Creatinine	81-91	troponin T2, cardiac type	Homo sapiens	29-33
29149950-6	2017	RESULTS: Creatinine clearance decreased from 94.3 +- 23 (t0) to 52.4 +- 22 mL/min/1.73 m2 (t0.1) and increased to 78.2 +- 19 mL/min/1.73 m2 after 10 years (t10).	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
29149950-6	2017	RESULTS: Creatinine clearance decreased from 94.3 +- 23 (t0) to 52.4 +- 22 mL/min/1.73 m2 (t0.1) and increased to 78.2 +- 19 mL/min/1.73 m2 after 10 years (t10).	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	128-133
29025775-3	2017	Creatinine levels at the time of gadolinium exposure were 0.9-1.2 mg/dL, with a corresponding estimated glomerular filtration rate of 64 mL/min/1.73m2 by modification of diet in renal disease equation.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	140-145
29228758-7	2017	Patients with higher serum fibrinogen levels had elevated serum creatinine levels, 24-hour urinary protein, and blood pressure compared with patients with the lowest levels of serum fibrinogen as well as severe renal damage at the time of renal biopsy.	Creatinine	64-74	fibrinogen beta chain	Homo sapiens	27-37
28197733-7	2017	When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength ([Formula: see text] and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 +- 1.43 mug/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 +- 0.76 mug/g creatinine).	Creatinine	299-309	fatty acid binding protein 1	Homo sapiens	173-179
28197733-7	2017	When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength ([Formula: see text] and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 +- 1.43 mug/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 +- 0.76 mug/g creatinine).	Creatinine	426-436	fatty acid binding protein 1	Homo sapiens	173-179
28392226-0	2017	The relationship of plasma creatinine (as eGFR) and high-sensitivity cardiac troponin and NT-proBNP concentrations in a hospital and community outpatient population.	Creatinine	27-37	epidermal growth factor receptor	Homo sapiens	42-46
28808068-3	2017	We found that compared with wild-type animals, mice lacking ACE2 developed much more severe hypertensive nephropathy in response to chronic angiotensin II infusion, including higher levels of blood pressure, urinary protein excretion, serum creatinine, and progressive renal fibrosis and inflammation.	Creatinine	241-251	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	60-64
28973352-9	2017	LRG1 independently predicted albuminuria progression above traditional risk factors, including baseline eGFR and urine albumin to creatinine ratio.	Creatinine	130-140	leucine rich alpha-2-glycoprotein 1	Homo sapiens	0-4
27269276-2	2017	The widespread use of ACE inhibitors has been associated with several notable adverse effects such as hyperkalemia and an increased serum creatinine.	Creatinine	138-148	angiotensin I converting enzyme	Homo sapiens	22-25
28429121-7	2017	Mean preoperative creatinine clearance was 80 ml/min/1.73 m2.	Creatinine	18-28	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
28429121-13	2017	The mean creatinine clearance at last follow-up was 104.3 ml/min/1.73 m2.	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
29036954-10	2017	Age, sepsis, serum creatinine were independent risk factors affecting hs-cTn T by multivariate linear regression analyses.	Creatinine	19-29	troponin T2, cardiac type	Homo sapiens	73-78
29018490-6	2017	In spite of the limited TLR4 activation with Pg-LPS, the TLR4 blocker eritoran decreased blood urea nitrogen and creatinine, and raised the survival rate of the Pg-LPS-administered diabetic mice slightly.	Creatinine	113-123	toll-like receptor 4	Mus musculus	57-61
28926966-8	2017	ARC is currently defined as an increased creatinine clearance of greater than 130 mL/min/1.73 m2 best measured by 8-24 h urine collection.	Creatinine	41-51	CD59 molecule (CD59 blood group)	Homo sapiens	85-90
29285224-3	2017	Median CXCL16 levels in urine was significantly higher in UC patients (273.2 pg/mg creatinine) compared to hospital (148.1 pg/mg) and population controls (85.1 pg/mg) with a particular preference for high grade (460.8 pg/mg), muscle invasive (535.7 pg/mg) and primary UC (327.8 pg/mg) (all p&lt;0.0001).	Creatinine	83-93	C-X-C motif chemokine ligand 16	Homo sapiens	7-13
28877681-5	2017	Urinary protein and serum creatinine levels were 3.38 g/gCr and 0.73 mg/dL.	Creatinine	26-36	nuclear receptor subfamily 3 group C member 1	Homo sapiens	56-59
28809733-5	2017	A positive correlation was found between PTX3 and serum creatinine (r = 0.220; p = 0.012), Chronic Liver Failure - Sequential Organ Failure Assessment score (CLIF-SOFA) (r = 0.220; p = 0.010), MELD (r = 0.279; p = 0.001) and Child-Pugh score (r = 0.224; p = 0.010).	Creatinine	56-66	pentraxin 3	Homo sapiens	41-45
28776340-7	2017	We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7 x 10-8) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine).	Creatinine	214-224	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-66
29021652-13	2017	CONCLUSIONS: Patients with urolithiasis have lower urine fetuin-A and creatinine-adjusted serum fetuin-A levels.	Creatinine	70-80	alpha 2-HS glycoprotein	Homo sapiens	96-104
28667079-4	2017	Notably, 2 weeks after the induction of GN with nephrotoxic serum, mice with a heterozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN, and serum creatinine levels significantly lower than those of wild-type animals.	Creatinine	174-184	gap junction protein, alpha 1	Mus musculus	108-119
28667079-4	2017	Notably, 2 weeks after the induction of GN with nephrotoxic serum, mice with a heterozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN, and serum creatinine levels significantly lower than those of wild-type animals.	Creatinine	174-184	gap junction protein, alpha 1	Mus musculus	126-141
28382566-12	2017	CONCLUSION: These results demonstration that TIMP-2*IGFBP-7 concentration can be used in infants to predict subsequent serum creatinine-defined AKI following CPB.	Creatinine	125-135	insulin like growth factor binding protein 7	Homo sapiens	52-59
28102552-7	2017	Among the studies considered, patients with OAB had a significant higher baseline urinary NGF/Cr (NGF normalized to urine creatinine) level compared to those of controls (SMD = 0.74, 95%CI = 0.43-1.04, P &lt; 0.00001).	Creatinine	122-132	nerve growth factor	Homo sapiens	90-93
28778164-20	2017	Treatment of rats with CCl4 markedly (P &lt; 0.01) increased the count of urinary red blood cells and leucocytes, concentration of urea, creatinine and urobilinogen and specific gravity whereas creatinine clearance was reduced.	Creatinine	137-147	C-C motif chemokine ligand 4	Rattus norvegicus	23-27
28847915-7	2017	In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein.	Creatinine	316-326	beta-1,3-glucuronyltransferase 1	Homo sapiens	63-67
28778164-20	2017	Treatment of rats with CCl4 markedly (P &lt; 0.01) increased the count of urinary red blood cells and leucocytes, concentration of urea, creatinine and urobilinogen and specific gravity whereas creatinine clearance was reduced.	Creatinine	194-204	C-C motif chemokine ligand 4	Rattus norvegicus	23-27
28778164-21	2017	Serum level of total protein, albumin, globulin, nitrite, creatinine and blood urea nitrogen (BUN) was significantly increased (P &lt; 0.01) by CCl4 treatment.	Creatinine	58-68	C-C motif chemokine ligand 4	Rattus norvegicus	144-148
27514393-7	2017	RESULTS: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios.	Creatinine	148-158	adiponectin, C1Q and collagen domain containing	Homo sapiens	39-50
28554541-10	2017	Albumin:creatinine ratio obtained by test strip and by wet chemistry showed a good correlation (r=0.59).	Creatinine	8-18	albumin	Homo sapiens	0-7
28554541-12	2017	CONCLUSIONS: Dye-binding based albumin test strip assay in combination with a CMOS based reader would potentially allow quantitative analysis of albuminuria and determination of albumin:creatinine ratio.	Creatinine	186-196	albumin	Homo sapiens	31-38
28593615-9	2017	Post-hoc analysis revealed significant differences in mean glucose to creatinine ratio change between type 2 diabetes and each monogenic diabetes in response to dapagliflozin (p = 0.02, p = 0.003 for HNF1-A and GCK MODY, respectively), but not between the two MODY forms (p = 0.7231).	Creatinine	70-80	HNF1 homeobox A	Homo sapiens	200-206
28110852-5	2017	Only in hypertensive women, was cTnT independently associated with urinary albumin-to-creatinine ratio (beta=0.25; p=0.019), pulse pressure (beta=0.31; p=0.019), Nt-proBNP (beta=0.47; p&lt;0.0001) and Cornell product (beta=0.31; p=0.018).	Creatinine	86-96	troponin T2, cardiac type	Homo sapiens	32-36
28110852-6	2017	An independent association between albumin-to-creatinine ratio and cTnT was also evident in normotensive women (beta=0.34; p=0.037).	Creatinine	46-56	troponin T2, cardiac type	Homo sapiens	67-71
28385297-4	2017	Fluid intake, urinary flow rate, urinary sodium/creatinine, and pH were significantly elevated in NHE3loxloxCre mice, while urine osmolality and GFR were significantly lower.	Creatinine	48-58	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	98-102
28934516-7	2017	Conclusion: Variability was found in AST:ALT and Urea:Crea, which resulted in a significant unnecessary financial burden and suggests the need to promote the optimal requesting rate.	Creatinine	54-58	solute carrier family 17 member 5	Homo sapiens	37-40
28752734-7	2017	Furthermore, there was a significant positive correlation between adiponectin and serum creatinine &amp;blood urea levels in both conservative and dialysis groups with P &lt;0.05.	Creatinine	88-98	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
28747177-10	2017	RESULTS: Positive correlations of DeltaCr were found with BUN, admission Cr, GRACE score, IL-1beta, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4.	Creatinine	39-41	interleukin 1 beta	Homo sapiens	90-98
28747177-10	2017	RESULTS: Positive correlations of DeltaCr were found with BUN, admission Cr, GRACE score, IL-1beta, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4.	Creatinine	39-41	interleukin 6	Homo sapiens	100-104
28924378-7	2017	Moreover, the amplification of the renal functional changes (decreased creatinine clearance and tubular injury with systemic inflammation, renal oxidative stress, and mitochondrial dysfunction) were prevented by the blockade of V1a and V2 vasopressin receptors with conivaptan.	Creatinine	71-81	arginine vasopressin	Rattus norvegicus	239-250
27638106-5	2017	Fabricated devices show high selectivity to CRP when compared with other target molecules, such as urea or creatinine, while maintaining a low detection limit (0.0625mg/L) and fast response time (61s).	Creatinine	107-117	C-reactive protein	Homo sapiens	44-47
28495930-6	2017	Adamts13-/- diabetic mice exhibited deterioration of kidney function (increased albuminuria, plasma creatinine, and urea; P&lt;0.05 versus WT diabetic mice), independent of hyperglycemia and hypertension.	Creatinine	100-110	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	0-8
28315733-8	2017	Notably, WT1 exhibited clinical and biological relevance as it was linked to dropped serum creatinine, decreased proteinuria and elevated estimated glomerular filtration rate (eGFR).	Creatinine	91-101	WT1 transcription factor	Homo sapiens	9-12
28648037-22	2017	Conclusions: Activating SIRT1 on early stage of severe burn in rats can decrease levels of creatinine and urea nitrogen, thus improving the kidney function.	Creatinine	91-101	sirtuin 1	Rattus norvegicus	24-29
28662085-8	2017	Metabolites such as allantoin, creatinine, proline, and methylamine could be predictive of AII/R injury.	Creatinine	31-41	NLR family pyrin domain containing 3	Homo sapiens	91-94
28637442-7	2017	Patients presenting with creatinine of &gt;120 mumol/L (1.36 mg/dL; corresponding to an eGFR of &lt;=60 ml/min in non-Black males) had an increased rate of ESRF and a faster decline.	Creatinine	25-35	epidermal growth factor receptor	Homo sapiens	88-92
28418911-7	2017	PSP/reg levels correlated positively with glycated hemoglobin (HbA1c) (p &lt; 0.001) and serum creatinine (p &lt; 0.001).	Creatinine	95-105	regenerating family member 1 alpha	Homo sapiens	0-3
28610620-4	2017	The eGFR was calculated from the creatinine level.	Creatinine	33-43	epidermal growth factor receptor	Homo sapiens	4-8
28344130-4	2017	After mild renal ischemia-reperfusion (IR), AQP3 null mice had significantly greater blood urea nitrogen (57mg/dl) and creatinine (136muM) than wild-type mice (35mg/dl and 48muM, respectively), and showed renal morphological changes, including tubular dilatation, erythrocyte diapedesis and collecting duct incompletion.	Creatinine	119-129	aquaporin 3	Mus musculus	44-48
28233611-8	2017	Both NKG2D and CDKN2A mRNA expression were significantly correlated with creatinine levels at 24 months after transplantation.	Creatinine	73-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	15-21
28570595-14	2017	In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index.	Creatinine	81-91	C-reactive protein	Homo sapiens	29-32
28506221-5	2017	Reduced renal function was defined as eGFR of less than 60 mL/min/1.73 m2 measured using serum creatinine concentration (mg/dL).	Creatinine	95-105	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
28572883-3	2017	RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0.918) between the Jaffe serum creatinine- and enzymatic serum creatinine-based CKD-EPI-eGFR, with 9% of discordant cases.	Creatinine	149-159	epidermal growth factor receptor	Homo sapiens	174-178
28302903-8	2017	Moreover, among individuals with baseline urinary albumin-to-creatinine ratio &gt;=30 mg/g, placebo-adjusted reductions in urinary albumin-to-creatinine ratio were larger in the lowest eGFR subgroup (P value interaction &lt;0.001).	Creatinine	61-71	epidermal growth factor receptor	Homo sapiens	185-189
28302903-8	2017	Moreover, among individuals with baseline urinary albumin-to-creatinine ratio &gt;=30 mg/g, placebo-adjusted reductions in urinary albumin-to-creatinine ratio were larger in the lowest eGFR subgroup (P value interaction &lt;0.001).	Creatinine	142-152	epidermal growth factor receptor	Homo sapiens	185-189
28418911-7	2017	PSP/reg levels correlated positively with glycated hemoglobin (HbA1c) (p &lt; 0.001) and serum creatinine (p &lt; 0.001).	Creatinine	95-105	regenerating family member 1 alpha	Homo sapiens	4-7
28575886-3	2017	This study aimed to investigate the association between donors" and recipients" GSTM1 and GSTT1 polymorphisms and DGF, creatinine clearance, and oxidative stress parameters in kidney allograft recipients.	Creatinine	119-129	glutathione S-transferase mu 1	Homo sapiens	80-85
28658750-3	2017	The estimation of eGFR by creatinine based formulae is known to be a rapid and reliable means of approximation of creatinine clearance.	Creatinine	26-36	epidermal growth factor receptor	Homo sapiens	18-22
28658750-3	2017	The estimation of eGFR by creatinine based formulae is known to be a rapid and reliable means of approximation of creatinine clearance.	Creatinine	114-124	epidermal growth factor receptor	Homo sapiens	18-22
28575886-11	2017	The recipients" GSTM1 polymorphism, alone and in combination with donors" GSTM1 and GSTT1, significantly affected the creatinine clearance on discharge day.	Creatinine	118-128	glutathione S-transferase mu 1	Homo sapiens	16-21
28575886-11	2017	The recipients" GSTM1 polymorphism, alone and in combination with donors" GSTM1 and GSTT1, significantly affected the creatinine clearance on discharge day.	Creatinine	118-128	glutathione S-transferase mu 1	Homo sapiens	74-79
28378551-5	2017	Changes in urinary levels of AGT (DeltaAGT) were calculated by subtracting urinary AGT/creatinine (Cr) at baseline from urinary AGT/Cr after 1 year.	Creatinine	87-97	angiotensinogen	Homo sapiens	29-32
28378551-5	2017	Changes in urinary levels of AGT (DeltaAGT) were calculated by subtracting urinary AGT/creatinine (Cr) at baseline from urinary AGT/Cr after 1 year.	Creatinine	87-97	angiotensinogen	Homo sapiens	39-42
28378551-5	2017	Changes in urinary levels of AGT (DeltaAGT) were calculated by subtracting urinary AGT/creatinine (Cr) at baseline from urinary AGT/Cr after 1 year.	Creatinine	87-97	angiotensinogen	Homo sapiens	39-42
28188955-8	2017	The number of cells per milligram of creatinine was significantly positively correlated with expression of all three mRNAs with correlation coefficients (R-value) of 0.442, 0.481, and 0.561 for Pod-, Nep-, and AQP2-mRNA, respectively.	Creatinine	37-47	membrane metalloendopeptidase	Homo sapiens	200-203
28653915-5	2017	The administration of CCl4 and AAP caused significant (p&lt;0.05) elevation in liver enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and other biochemical parameters, bilirubin, glucose, triglyceride and kidney function markers: urea and creatinine.	Creatinine	321-331	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
28658750-8	2017	RESULTS: The eGFR by MDRD formulae had a statistically insignificant p-value (p &gt; 0.05) i.e., good approximation in the IInd, IIIrd, IVth and Vth stages of CKD on comparison with 24 hour creatinine clearance.	Creatinine	190-200	epidermal growth factor receptor	Homo sapiens	13-17
30603346-5	2017	The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching.	Creatinine	22-32	epidermal growth factor receptor	Homo sapiens	169-173
30603346-5	2017	The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching.	Creatinine	22-32	epidermal growth factor receptor	Homo sapiens	169-173
28507917-4	2017	Glomerular filtration rate (GFR) and serum creatinine were significantly better in mTOR inhibitor group with equivalent survival at 12 mo, even though Biopsy Proven Acute rejection was significantly higher in mTOR-inhibitor group.	Creatinine	43-53	mechanistic target of rapamycin kinase	Homo sapiens	83-87
28507917-6	2017	The mTOR inhibitors such as everolimus and sirolimus, due to their complementary mechanism of action and favourable nephrotoxicity profile; better glomerular filtration, lower serum creatinine with equivalent survival.	Creatinine	182-192	mechanistic target of rapamycin kinase	Homo sapiens	4-8
28571184-9	2017	There were statistically significant positive correlations between serum levels of L-FABP and Aspartate Aminotransferases (AST), Alanine Aminotransferases (ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT) (p&lt;0.001, p&lt;0.001, p&lt;0.001 and p&lt;0.001, respectively).	Creatinine	162-172	fatty acid binding protein 1	Homo sapiens	83-89
28406086-0	2017	Postprandial serum C-peptide level is associated with increased urinary albumin-to-creatinine ratio in patients with type 2 diabetes mellitus.	Creatinine	83-93	insulin	Homo sapiens	19-28
28344754-5	2017	A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric (&gt;= 30 and &lt; 300 mg/g creatinine) or macro-albuminuric (&gt;= 300 mg/g creatinine) at the time of enrollment.	Creatinine	171-181	angiotensin I converting enzyme	Homo sapiens	70-73
28031343-5	2017	eGFR was estimated with the CKD-EPI creatinine-cystatin C equation.	Creatinine	36-46	epidermal growth factor receptor	Homo sapiens	0-4
27894952-3	2017	METHODS: Using a cross-sectional analysis from the eGFR Study of 654 Indigenous Australians at high risk of ESKD, eGFR was calculated using the CKD-EPI equations for serum creatinine (eGFRcr), cystatin C (eGFRcysC) and combined creatinine and cystatin C (eGFRcysC+cr).	Creatinine	172-182	epidermal growth factor receptor	Homo sapiens	114-118
27894952-3	2017	METHODS: Using a cross-sectional analysis from the eGFR Study of 654 Indigenous Australians at high risk of ESKD, eGFR was calculated using the CKD-EPI equations for serum creatinine (eGFRcr), cystatin C (eGFRcysC) and combined creatinine and cystatin C (eGFRcysC+cr).	Creatinine	228-238	epidermal growth factor receptor	Homo sapiens	114-118
27894952-12	2017	CKD-EPI eGFR based on serum creatinine remains the preferred equation in Indigenous Australians.	Creatinine	28-38	epidermal growth factor receptor	Homo sapiens	8-12
28344754-5	2017	A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric (&gt;= 30 and &lt; 300 mg/g creatinine) or macro-albuminuric (&gt;= 300 mg/g creatinine) at the time of enrollment.	Creatinine	220-230	angiotensin I converting enzyme	Homo sapiens	70-73
28277542-10	2017	Notably, miR-27a exhibited clinical and biological relevance as it was linked to elevated serum creatinine, proteinuria and reduced creatinine clearance rate.	Creatinine	96-106	microRNA 27a	Homo sapiens	9-16
28277542-10	2017	Notably, miR-27a exhibited clinical and biological relevance as it was linked to elevated serum creatinine, proteinuria and reduced creatinine clearance rate.	Creatinine	132-142	microRNA 27a	Homo sapiens	9-16
28148558-10	2017	CONCLUSIONS: The histopathologic classification of ANCA-associated GN in combination with serum creatinine and serum albumin levels and treatment regimen is associated with renal outcome in myeloperoxidase-ANCA-associated GN.	Creatinine	96-106	myeloperoxidase	Homo sapiens	190-205
28270222-12	2017	The ABCG2 associations persisted in the Western Polynesian group after adjusting for serum urate, creatinine, and disease duration, and when including both ABCG2 variants in the regression models.	Creatinine	98-108	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	4-9
28148558-11	2017	The evaluation of serum creatinine level and percentage of global sclerotic glomeruli provides additional information on the risk of renal survival in the sclerotic class of myeloperoxidase-ANCA-associated GN.	Creatinine	24-34	myeloperoxidase	Homo sapiens	174-189
27557726-7	2017	Elevations in serum creatinine concentrations postoperative 48 h were significantly suppressed in the programmed insulin group.	Creatinine	20-30	insulin	Homo sapiens	113-120
27988799-8	2017	The separation time for hippuric acid, mandelic acid, and creatinine was less than 70 s. The evaluation of some analytical parameters of the method for the three analytes showed good linearity (R 2 &gt; 0.99), limit of detections of 0.21 to 0.63 mg L-1, inter-day precision better than 3.0% (peak area), and recovery in the range of 98 to 106%.	Creatinine	58-68	immunoglobulin kappa variable 1-16	Homo sapiens	249-252
28279964-0	2017	Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study.	Creatinine	6-16	renin	Homo sapiens	33-38
28081262-7	2017	Hazard ratios (HRs) [95% confidence intervals (CIs)] for statin treatment for the doubling of serum creatinine levels were significant only in CKD patients with an estimated glomerular filtration rate (eGFR) &gt;=30 mL/min/1.73 m2, and were 0.744 (0.635-0.873) in the unmatched cohort and 0.767 (0.596-0.986) in the matched cohort.	Creatinine	100-110	CD59 molecule (CD59 blood group)	Homo sapiens	219-224
28125604-6	2017	Glomerular filtration rate (eGFR) was estimated based on creatinine levels.	Creatinine	57-67	epidermal growth factor receptor	Homo sapiens	28-32
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	fibronectin 1	Homo sapiens	63-76
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	fibronectin 1	Homo sapiens	78-81
28088951-12	2017	The dynamic level of urinary Fractalkine in AR patients within 3 weeks after transplantation fluctuated above 300 ng/mmol creatine, which is remarkably higher than patients with stable renal function (below 200 ng/mmol creatinine).	Creatinine	219-229	C-X3-C motif chemokine ligand 1	Homo sapiens	29-40
27537378-9	2017	Multivariate analysis revealed that the norepinephrine level at 24-hour collected urine (24 h U-NE) and the serum creatinine level were independent determinants of %NBPF (adjusted R2 = 0.20; 24 h U-NE, p = 0.0001; serum creatinine, p = 0.04).	Creatinine	114-124	NBPF member 1	Homo sapiens	165-169
27827312-15	2017	Jaffe assays yield higher Cr values than enzymatic assays, leading to lower eGFR-EPIs and more frequent CKD diagnoses.	Creatinine	26-28	epidermal growth factor receptor	Homo sapiens	76-80
28972944-5	2017	Peak creatinine levels were &gt;4 times above the baseline and estimated glomerular filtration rates were reduced to &lt;30 mL/min/1.73 m2.	Creatinine	5-15	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
28614813-4	2017	Treatment with vasopressin V2-receptor antagonist tolvaptan has been shown to inhibit disease progression in experimental studies, as well as in a large randomized controlled trial involving 1,445 patients with autosomal dominant PKD, lowering total kidney volume growth from 5.5 to 2.8%, and the slope of the reciprocal of the serum creatinine level from -3.81 to -2.61 mg per mL-1/year.	Creatinine	334-344	arginine vasopressin receptor 2	Homo sapiens	15-38
28577875-6	2017	Creatinine correlated with miR-192 (r = 0.414, p = 0.036) and miR-423-3p (r = -0.431, p = 0.028).	Creatinine	0-10	microRNA 192	Homo sapiens	27-34
28577875-6	2017	Creatinine correlated with miR-192 (r = 0.414, p = 0.036) and miR-423-3p (r = -0.431, p = 0.028).	Creatinine	0-10	microRNA 423	Homo sapiens	62-69
28601119-12	2017	CONCLUSIONS: The urinary VEGF/creatinine ratio in 24-hour urine seems to independently predict worsening of chronic kidney disease in patients with glomerular diseases.	Creatinine	30-40	vascular endothelial growth factor A	Homo sapiens	25-29
27287302-7	2017	However, both counts, of eotaxin-1 and eosinophils, were related to the cotinine/creatinine ratio.	Creatinine	81-91	C-C motif chemokine ligand 11	Homo sapiens	25-34
28154269-4	2017	Results A multiple logistic regression analysis adjusted for age, duration of diabetes, observation period, body mass index, HbA1c, serum creatinine, and the bone mineral density at the lumbar spine showed that the serum IGF-I level was significantly and inversely associated with the incidence of non-vertebral osteoporotic fractures in postmenopausal women (odds ratio =0.48, 95% confidential interval [CI] 0.23-0.99 per SD increase; p=0.047), but not in men.	Creatinine	138-148	insulin like growth factor 1	Homo sapiens	221-226
28321056-6	2017	The urinary albumin/creatinine ratio (U-ACR) was significantly reduced in the patients whose U-ACR levels were 30-300 mg/gCr at the baseline.	Creatinine	20-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	121-124
27401687-4	2017	Participants with baseline pro-ENK levels in the highest tertile had significantly greater yearly mean decline of eGFR (Ptrend&lt;0.001) and rise of cystatin C (Ptrend=0.01) and creatinine (Ptrend&lt;0.001) levels.	Creatinine	178-188	proenkephalin	Homo sapiens	27-34
27218216-7	2017	The expressions of serum IGF-1, TNF-alpha and VEGF165 in the type 2 DN patients were positively correlated with UALB/Cr (all P &lt; 0.05).	Creatinine	117-119	insulin like growth factor 1	Homo sapiens	25-30
27218216-7	2017	The expressions of serum IGF-1, TNF-alpha and VEGF165 in the type 2 DN patients were positively correlated with UALB/Cr (all P &lt; 0.05).	Creatinine	117-119	tumor necrosis factor	Homo sapiens	32-41
28074703-8	2017	Results Postoperative creatinine clearance was lower in patients who underwent surgery &lt;=3 days after coronary angiography (63.57 +- 38.52 mL min-1) compared to &gt;=8 days after coronary angiography (74.56 +- 54.25 mL min-1, p = 0.015).	Creatinine	22-32	CD59 molecule (CD59 blood group)	Homo sapiens	145-150
28074703-8	2017	Results Postoperative creatinine clearance was lower in patients who underwent surgery &lt;=3 days after coronary angiography (63.57 +- 38.52 mL min-1) compared to &gt;=8 days after coronary angiography (74.56 +- 54.25 mL min-1, p = 0.015).	Creatinine	22-32	CD59 molecule (CD59 blood group)	Homo sapiens	222-227
28074703-9	2017	Patients who underwent surgery &lt;=3 days after coronary angiography had higher hospital mortality when preoperative creatinine clearance was &lt;=60 mL min-1 (12% vs. 4% for creatinine clearance &lt;=and &gt;60 mL min-1, respectively; p = 0.039).	Creatinine	118-128	CD59 molecule (CD59 blood group)	Homo sapiens	154-159
28230891-8	2017	CONCLUSIONS: PTH is significantly elevated in non-ischaemic HF patients compared to non-HF volunteers and correlates with established factors of worse prognosis, including age, estimated glomerular filtration rate (eGFR), aspartate aminotransferase (AST), serum concentrations of creatinine, and NT-proBNP.	Creatinine	280-290	parathyroid hormone	Homo sapiens	13-16
28596788-6	2017	We were able to construct the following model to predict the log-transformed CEA level: log (CEA + 0.51) = -0.204 - 0.051 (gender) + 0.005 (age) - 0.006 (BMI) + 0.008 (WBC count) + 0.016 (HB) + 0.002 (AST) + 0.062 (creatinine) + 0.054 (HbA1c).	Creatinine	215-225	CEA cell adhesion molecule 3	Homo sapiens	77-80
28596788-6	2017	We were able to construct the following model to predict the log-transformed CEA level: log (CEA + 0.51) = -0.204 - 0.051 (gender) + 0.005 (age) - 0.006 (BMI) + 0.008 (WBC count) + 0.016 (HB) + 0.002 (AST) + 0.062 (creatinine) + 0.054 (HbA1c).	Creatinine	215-225	CEA cell adhesion molecule 3	Homo sapiens	93-96
27783968-5	2017	RESULTS: In the FMH treated patients, eGFR improved following the procedure from 37ml/min per 1.73m2 at baseline to 39ml/min per 1.73m2 (p&lt;0.001); the net creatinine decreased from 1.85mg/dl to 1.78mg/dl (p&lt;0.001).	Creatinine	158-168	epidermal growth factor receptor	Homo sapiens	38-42
27783968-6	2017	Among the matched control group, eGFR deteriorated from a baseline value of 36.7ml/min per 1.73m2 to 33.2ml/min per 1.73m2 post procedurally (p&lt;0.001); the net creatinine increased from 1.88mg/dl to 2.14mg/dl (p&lt;0.001).	Creatinine	163-173	epidermal growth factor receptor	Homo sapiens	33-37
27783968-10	2017	CONCLUSIONS: In patients undergoing coronary angiography, angioplasty or TAVR, who are considered high risk to develop post procedural AKI, forced diuresis with matched controlled hydration resulted in a significant net creatinine decrease, eGFR increase and a decrease in the incidence of AKI.	Creatinine	220-230	epidermal growth factor receptor	Homo sapiens	241-245
28057871-10	2017	During follow-up, the highest tertile of baseline copeptin was positively associated with the incidence of the composite renal outcome as well as with the individual components of doubling of creatinine, ESRD and start of immunosuppressive therapy.	Creatinine	192-202	arginine vasopressin	Homo sapiens	50-58
28867699-3	2017	Creatinine clearance is generally between 10 and 40 mL/min in Japanese patients, so TAZ/PIPC is given at a dose of 2.25 g three times daily or 4.5 g twice daily.	Creatinine	0-10	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	84-87
28966268-4	2017	The patients who exhibited high serum creatinine (SCr) levels before administration, exhibited significant increases of AST (p=0.0121).	Creatinine	38-48	solute carrier family 17 member 5	Homo sapiens	120-123
27992580-10	2016	UPodo/gCr was directly related to urine protein creatinine ratio (r = 0.33; p = 0.04) in all Fabry patients.	Creatinine	48-58	nuclear receptor subfamily 3 group C member 1	Homo sapiens	6-9
28828166-6	2017	Glomerular filtration rate (GFR) and serum creatinine were better in mTOR inhibitor group at 12 months.	Creatinine	43-53	mechanistic target of rapamycin kinase	Homo sapiens	69-73
28828166-9	2017	The mTOR inhibitors are more favorable due to their complementary mechanism of action and favorable nephrotoxicity profile, better glomerular filtration, and lower serum creatinine with equivalent survival.	Creatinine	170-180	mechanistic target of rapamycin kinase	Homo sapiens	4-8
29043138-2	2016	In particular, crescentic IgA nephropathy has a poor prognosis in patients with a higher initial serum creatinine level.	Creatinine	103-113	CD79a molecule	Homo sapiens	26-29
27663042-7	2016	BTP was associated less strongly with age, similar in direction with sex, and opposite in direction with race than creatinine level.	Creatinine	115-125	prostaglandin D2 synthase	Homo sapiens	0-3
28164545-6	2016	RESULTS: In the AICD cohort, zonulin associated inversely with serum creatinine (p = 0.013), carboxymethyl-lysine calprotectin (p &lt; 0.001), and kynurenine (p = 0.009) and positively with homoarginine (p &lt; 0.001).	Creatinine	69-79	haptoglobin	Homo sapiens	29-36
27779570-4	2017	RESULTS: Glomerular filtration rate estimated by serum creatinine was significantly higher in recipients carrying allograft with the A allele at rs17319721 in SHROOM3 (shroom family member 3) than those in the group with the GG genotype from month 1 to month 6 after transplantation (P=0.020).	Creatinine	55-65	shroom family member 3	Homo sapiens	159-166
27779570-4	2017	RESULTS: Glomerular filtration rate estimated by serum creatinine was significantly higher in recipients carrying allograft with the A allele at rs17319721 in SHROOM3 (shroom family member 3) than those in the group with the GG genotype from month 1 to month 6 after transplantation (P=0.020).	Creatinine	55-65	shroom family member 3	Homo sapiens	168-190
28164545-9	2016	CONCLUSIONS: The inverse associations of zonulin with creatinine and markers of cardio-vascular risk (high CMLcalprotectin and kynurenine, low homoarginine) are novel findings that need further experimental and clinical clarification.	Creatinine	54-64	haptoglobin	Homo sapiens	41-48
27059513-8	2016	Decline in eGFR was superior to other surrogates, including acute rejection, doubling of serum creatinine level, and eGFR at year 1 or year 2.	Creatinine	95-105	epidermal growth factor receptor	Homo sapiens	11-15
27906636-9	2016	In the absence of allopurinol, plasma creatinine levels of some Urat1-Uox-DKO mice were higher than those of Uox-KO mice.	Creatinine	38-48	urate oxidase	Mus musculus	70-73
27425010-4	2016	RESULTS: A significant reduction in urine C-peptide/creatinine ratio, measured after a mixed-meal, was reached at 9 months (-45.4%), whilst the reduction in stimulated serum C-peptide level reached significance after 3 months (-54.7%) in placebo-treated participants.	Creatinine	52-62	insulin	Homo sapiens	42-51
27930558-5	2016	Urinary excretion of BTP and albumin was expressed as mg/g urinary creatinine.	Creatinine	67-77	prostaglandin D2 synthase	Homo sapiens	21-24
27930558-6	2016	Fractional clearance of BTP was calculated as the ratio of BTP clearance to creatinine clearance (%).Urinary excretion of BTP is mainly determined by its serum concentration and by the level of GFR, and to a lower extent by urinary albumin excretion.	Creatinine	76-86	prostaglandin D2 synthase	Homo sapiens	24-27
27707584-11	2016	There was a positive correlation between fibronectin in the tubulointerstitial compartment and creatinine levels, between alpha-SMA and vimentin in both tubulointerstitial and glomerular compartments, and between urea and creatinine levels of patients, regardless of their nephropathy (p&lt;0.05 for all results).	Creatinine	95-105	fibronectin 1	Homo sapiens	41-52
27425010-0	2016	Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of beta-cell function in the first year after diagnosis of Type 1 diabetes.	Creatinine	27-37	insulin	Homo sapiens	17-26
27813552-6	2016	The Asp298 and 4a alleles of the eNOS gene were found to be significantly associated with increased levels of urea and creatinine, and a decreased glomerular filtration rate in FD patients, and this association behaved in a co-dominant fashion.	Creatinine	119-129	nitric oxide synthase 3	Homo sapiens	33-37
27404700-9	2016	Copeptin values significantly increased with decreasing eGFR (p&lt;0.001) and were strongly correlated with creatinine values (r=0.567, p&lt;0.001).	Creatinine	108-118	arginine vasopressin	Homo sapiens	0-8
27812309-8	2016	Within 10 to 60 years of age, a preliminary reference range for urinary orosomucoid/creatinine ratio (u-ORM/u-CREAT) was found to be 0.08 (0.01-0.24) mg/mmol [median (2.5-97.5 percentiles)].	Creatinine	84-94	orosomucoid 1	Homo sapiens	104-107
27621181-7	2016	RESULTS: At baseline follistatin levels were correlated with creatinine (r=0.24; p=0.01), creatine phosphokinase (rs=0.22; p=0.02), and with lean body mass (rs=0.19; p=0.04) and were higher in males than females (p=0.004) after adjustment for leptin, which was its major predictor.	Creatinine	61-71	follistatin	Homo sapiens	21-32
27208798-6	2016	Moreover, the mice in the GLP-M and GLP-H groups had longer survival times compared with the mice in the TCG and PCG.The levels of creatinine and serum blood urea nitrogen, which are up-regulated by cisplatin, were significantly reduced by GLP-M and GLP-H.	Creatinine	131-141	psoriasis susceptibility 1 candidate 2 (human)	Mus musculus	113-116
27324913-5	2016	Among them, seven patients had a baseline creatinine clearance (CrCl) &lt;50 ml min(-1) (case).	Creatinine	42-52	CD59 molecule (CD59 blood group)	Homo sapiens	80-86
27499050-11	2016	An inverse correlation was found between TGF-beta levels and dialysate/plasmatic creatinine values (r = -0.83; p = 0.03).	Creatinine	81-91	transforming growth factor beta 1	Homo sapiens	41-49
26609639-8	2016	RESULTS: Serum creatinine measured was significantly lower after IPC and even lower in combination with Gal-9 injection.	Creatinine	15-25	lectin, galactose binding, soluble 9	Mus musculus	104-109
26980004-3	2016	Of the 20 participants in this study, the urinary NAG/creatinine (Cr) rose from a pre-exercise level of 8.9, 6.7 to 14.3 (mumol/L/mmol Cr; median, IQR) to 12.9, 9.1 to 17.7 post exercise (p = 0.0003, Mann Whitney U test).	Creatinine	54-64	N-acetyl-alpha-glucosaminidase	Homo sapiens	50-53
27340283-7	2016	eGFR creatinine overestimated measured GFR by 3.1% (percentage of estimates within 30% of measured GFR of 80.4%), and eGFR Modification of Diet in Renal Disease underestimated measured GFR by 2.2% (percentage of estimates within 30% of measured GFR of 80.4%).	Creatinine	5-15	epidermal growth factor receptor	Homo sapiens	0-4
27340283-8	2016	eGFR cystatin C underestimated measured GFR by -13.7% (percentage of estimates within 30% of measured GFR of 77.1%), and eGFR creatinine-cystatin C underestimated measured GFR by -8.1% (percentage of estimates within 30% of measured GFR of 86.5%).	Creatinine	126-136	epidermal growth factor receptor	Homo sapiens	121-125
27340283-11	2016	CONCLUSIONS: Thus, eGFR creatinine and eGFR creatinine-cystatin C are preferred over eGFR cystatin C in kidney transplant recipients because they are less biased, more accurate, and more consistently reflect the same risk factor associations seen with measured GFR.	Creatinine	24-34	epidermal growth factor receptor	Homo sapiens	19-23
27340283-11	2016	CONCLUSIONS: Thus, eGFR creatinine and eGFR creatinine-cystatin C are preferred over eGFR cystatin C in kidney transplant recipients because they are less biased, more accurate, and more consistently reflect the same risk factor associations seen with measured GFR.	Creatinine	44-54	epidermal growth factor receptor	Homo sapiens	39-43
27340283-11	2016	CONCLUSIONS: Thus, eGFR creatinine and eGFR creatinine-cystatin C are preferred over eGFR cystatin C in kidney transplant recipients because they are less biased, more accurate, and more consistently reflect the same risk factor associations seen with measured GFR.	Creatinine	44-54	epidermal growth factor receptor	Homo sapiens	39-43
27115790-7	2016	Severe renal impairment (creatinine clearance &lt;30 ml min(-1) ; n = 3) decreased ADC exposures (0.71 [0.54, 0.94]) and increased MMAE exposures (1.90 [0.85, 4.21]).	Creatinine	25-35	CD59 molecule (CD59 blood group)	Homo sapiens	56-62
27353644-4	2016	RESULTS: The urinary IL-6 concentrations increased from uACR &lt;10 (97.2+-26.4pg/ml) to uACR 10-30 (113.6+-28.0pg/ml) and to uACR &gt;30mg/g creatinine (163.5+-25.6pg/ml) (P&lt;0.05 and P&lt;0.001, respectively) patients.	Creatinine	142-152	interleukin 6	Homo sapiens	21-25
27270293-7	2016	RESULTS: In pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {beta = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [beta = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)].	Creatinine	70-80	epidermal growth factor receptor	Homo sapiens	145-149
27270293-7	2016	RESULTS: In pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {beta = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [beta = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)].	Creatinine	70-80	CD59 molecule (CD59 blood group)	Homo sapiens	174-179
27242017-0	2016	Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study.	Creatinine	30-40	parathyroid hormone	Homo sapiens	81-100
27400799-5	2016	At the early stage of AKI, serum miR-146b levels exhibited a rapid increase that was even faster than that of two conventional renal function indexes: serum creatinine and blood urea nitrogen levels.	Creatinine	157-167	microRNA 146b	Rattus norvegicus	33-41
27349183-7	2016	In Cox regression analyses adjusted for age, duration of diabetes, body mass index, HbA1c, and serum creatinine, serum IGF-I was inversely associated with the mortality [men, hazard ratio (HR)=0.40, 95% confidence interval (CI)=0.25-0.64 per SD increase, p&lt;0.001; women, HR=0.28, 95%CI 0.08-0.96, p=0.043].	Creatinine	101-111	insulin like growth factor 1	Homo sapiens	119-124
27742310-9	2016	A urine protein-creatinine ratio &gt;=0.3 g/gCr was found in 14 patients and was more common in the ECLDs than in the standard-criteria living donors.	Creatinine	16-26	nuclear receptor subfamily 3 group C member 1	Homo sapiens	44-47
27866548-11	2016	The levels of the plasma Bun and Cr in Poisoned and intervention group were significantly higher than that in Control group in the six to seventy-two hours (P&lt;0.01) ; Whereas the increases of Bun and Cr were markedly intibited in PEP-1/HO-1 intervention group, in which, the levels of Bun and Cr in the six to seventy-two hours were significantly lower than Poisoned group (P&lt;0.05).	Creatinine	203-205	neuronal vesicle trafficking associated 1	Rattus norvegicus	233-238
27866548-11	2016	The levels of the plasma Bun and Cr in Poisoned and intervention group were significantly higher than that in Control group in the six to seventy-two hours (P&lt;0.01) ; Whereas the increases of Bun and Cr were markedly intibited in PEP-1/HO-1 intervention group, in which, the levels of Bun and Cr in the six to seventy-two hours were significantly lower than Poisoned group (P&lt;0.05).	Creatinine	203-205	neuronal vesicle trafficking associated 1	Rattus norvegicus	233-238
27530158-15	2016	MBM administration significantly alleviated the toxic effect of CCl4 in rat and decreased the elevated level of RBCs, pus and epithelial cells, specific gravity, creatinine, urobilinogen, urea and albumin while increased the pH and urinary protein.	Creatinine	162-172	C-C motif chemokine ligand 4	Rattus norvegicus	64-68
27515948-9	2016	Median Gal-9 levels were higher in patients with blood urea nitrogen to creatinine ratio (BUN/creatinine) &gt;=20 (mg/dL) than in patients with BUN/creatinine &lt;20 (mg/dL) at day 0 (817.3 vs 576.2 pg/mL, P = 0.007).	Creatinine	72-82	galectin 9	Homo sapiens	7-12
27561093-5	2016	Our second aim was to find an association between MMPs, TIMP and creatinine.	Creatinine	65-75	TIMP metallopeptidase inhibitor 1	Homo sapiens	56-60
27561093-15	2016	MMP-7 and TIMP-1 correlated weakly with creatinine (Rho = 0.221 and 0.243).	Creatinine	40-50	TIMP metallopeptidase inhibitor 1	Homo sapiens	10-16
27515948-9	2016	Median Gal-9 levels were higher in patients with blood urea nitrogen to creatinine ratio (BUN/creatinine) &gt;=20 (mg/dL) than in patients with BUN/creatinine &lt;20 (mg/dL) at day 0 (817.3 vs 576.2 pg/mL, P = 0.007).	Creatinine	94-104	galectin 9	Homo sapiens	7-12
27515948-9	2016	Median Gal-9 levels were higher in patients with blood urea nitrogen to creatinine ratio (BUN/creatinine) &gt;=20 (mg/dL) than in patients with BUN/creatinine &lt;20 (mg/dL) at day 0 (817.3 vs 576.2 pg/mL, P = 0.007).	Creatinine	94-104	galectin 9	Homo sapiens	7-12
27189318-8	2016	C statistic for traditional predictors of eGFR decline was 0.70, which improved significantly to 0.74 with monocyte chemotactic protein-1-to-creatinine ratio.	Creatinine	141-151	epidermal growth factor receptor	Homo sapiens	42-46
27307060-7	2016	Urinary and plasmatic levels of TNF-alpha were positively correlated with plasma levels of cystatin C, creatinine, urea and albuminuria, while they were negatively correlated with estimated glomerular filtration rate.	Creatinine	103-113	tumor necrosis factor	Homo sapiens	32-41
27181911-13	2016	For the alkaline picrate methods, a measured change of creatinine of 0.23mg/dL for AP1 or 0.11mg/dL for AP2 would indicate that a physiologic change in serum/plasma creatinine has occurred.	Creatinine	55-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-86
27181911-13	2016	For the alkaline picrate methods, a measured change of creatinine of 0.23mg/dL for AP1 or 0.11mg/dL for AP2 would indicate that a physiologic change in serum/plasma creatinine has occurred.	Creatinine	165-175	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-86
27233528-9	2016	Furthermore, a simple regression analysis has shown that serum PTX3 concentrations in patients with T2DM were negatively correlated with body mass index, and positively correlated with blood urea nitrogen, serum creatinine, and UAE.	Creatinine	212-222	pentraxin 3	Homo sapiens	63-67
27540462-4	2016	RESULTS: Compared with human insulin, multiple regression analysis taking into account possible confounders revealed that treatment with insulin analogs was associated with increased eGFR (+7.1 ml/min; P=0.0002), lower urinary albumin/creatinine ratio (ratio logarithm -0.4; P=0.003) and higher hemoglobin concentration (+0.31 g/dl; P=0.04).	Creatinine	235-245	insulin	Homo sapiens	137-144
27446345-9	2016	Multivariate analysis showed that the serum expression levels of creatinine [micromol/l; odds radio (OR), 1.003; 95% confidence interval (CI), 1.002-1.004; P=0.001] and phosphorus (mmol/l; OR, 2.19; 95% CI, 1.254-3.826; P=0.006) in patients with CKD significantly influenced serum PTH expression levels.	Creatinine	65-75	parathyroid hormone	Homo sapiens	281-284
27540462-7	2016	CONCLUSIONS: Present results suggest that treatment of type 1 diabetic patients with normal and impaired renal function with insulin analogs, especially Glargine and Lispro, is associated with better kidney function, lower urinary albumin/creatinine ratio and lower hemoglobin concentration compared to therapy with human insulin.	Creatinine	239-249	insulin	Homo sapiens	125-132
24467624-7	2016	Also, urinary adiponectin/creatinine ratio was significantly higher in the former group (221.72 +- 414.58 vs. 19.99 +- 41.19, P = 0.019).	Creatinine	26-36	adiponectin, C1Q and collagen domain containing	Homo sapiens	14-25
26830660-2	2016	Unlike previous reports, both types of isomer species, hydride [PC(EHn-1Ph4-n)P]PdH or [PC(Bpin)P]PdH and silyl/germyl [PC(H)P]Pd(EHn-1Ph4-n), were observed depending on the substrate and the phosphine ligand, showing that the polarity of the Pd-C bond can be tuned by the phosphine substituents.	Creatinine	55-62	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	80-83
26895008-10	2016	Serum myostatin levels were significantly and positively associated with lean body mass measured by the creatinine kinetic method and negatively associated with the use of VDRAs after adjustment for potential confounding factors.	Creatinine	104-114	myostatin	Homo sapiens	6-15
27253174-8	2016	Serum creatinine levels were significantly correlated with serum IGF-1 levels.	Creatinine	6-16	insulin like growth factor 1	Homo sapiens	65-70
26538632-8	2016	mTOR pathway inhibition in KIM-1-overexpressing transgenic mice also significantly ameliorated serum creatinine level, proteinuria, tubular injury, and kidney inflammation.	Creatinine	101-111	mechanistic target of rapamycin kinase	Homo sapiens	0-4
27546928-0	2016	Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease.	Creatinine	94-104	angiotensin I converting enzyme	Homo sapiens	27-56
27398022-6	2016	Similarly, urinary NAG levels increased significantly at three hours (3.9 vs. 2.2 IU/mg creatinine; P &lt; 0.001).	Creatinine	88-98	N-acetyl-alpha-glucosaminidase	Homo sapiens	19-22
27330813-9	2016	L-FABP levels were 601.5 +- 341.7 and 233.8 +- 127.2 mug/g Cr in the AKI and non-AKI groups, respectively.	Creatinine	59-61	fatty acid binding protein 1	Homo sapiens	0-6
27076636-13	2016	Across baseline eGFR categories, annual eGFR decline was greatest among adults with baseline albumin-to-creatinine ratio (ACR) &gt;265 mg/g (30 mg/mmol).	Creatinine	104-114	epidermal growth factor receptor	Homo sapiens	16-20
27358912-8	2016	Thus, 14 days after ischemia/reperfusion injury, the renal expression of profibrotic factors, serum creatinine, and blood pressure were lower in mice infused with DRD2 AAV than in those infused with control AAV.	Creatinine	100-110	dopamine receptor D2	Mus musculus	163-167
27386484-6	2016	Using the median value for ALP as cut-off (74 IU/L), plasma creatinine was significantly higher in patients with higher values for ALP.	Creatinine	60-70	alkaline phosphatase, placental	Homo sapiens	27-30
27386484-6	2016	Using the median value for ALP as cut-off (74 IU/L), plasma creatinine was significantly higher in patients with higher values for ALP.	Creatinine	60-70	alkaline phosphatase, placental	Homo sapiens	131-134
27076636-13	2016	Across baseline eGFR categories, annual eGFR decline was greatest among adults with baseline albumin-to-creatinine ratio (ACR) &gt;265 mg/g (30 mg/mmol).	Creatinine	104-114	epidermal growth factor receptor	Homo sapiens	40-44
27438982-13	2016	The patient received corticotherapy and strict control of glycemia with insulin, with marked improvement of symptoms and creatinine levels.	Creatinine	121-131	insulin	Homo sapiens	72-79
26445954-6	2016	Univariate linear regression analysis showed that the serum adiponectin concentrations were correlated with age, the albumin-to-creatinine ratio, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, whereas they were negatively correlated with body mass index, the estimated glomerular filtration rate, and serum albumin and triglyceride levels.	Creatinine	128-138	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
26649562-1	2016	BACKGROUND: The urinary protein/creatinine ratio [Up/Ucr (g/gCr)] has been used in the clinical management of patients with chronic kidney disease (CKD).	Creatinine	32-42	nuclear receptor subfamily 3 group C member 1	Homo sapiens	60-63
27317936-7	2016	Urinary vanin-1, but not KIM-1, NGAL and NAG, significantly elevated early on day 3 after cisplatin, which preceded the elevation of serum creatinine on day 6.	Creatinine	139-149	vanin 1	Homo sapiens	8-15
27001371-7	2016	Sclerostin correlated with parameters of dialysis adequacy, such as creatinine levels and Kt/V values, and it was significantly associated with atherosclerotic disease.	Creatinine	68-78	sclerostin	Homo sapiens	0-10
27077596-9	2016	Serum creatinine was lower in TLR4 allografts at day 14 posttransplantation compared with WT allografts, but this was not sustained by day 100.	Creatinine	6-16	toll-like receptor 4	Mus musculus	30-34
26053785-8	2016	Creatinine at 1 year increased by 0.121 mg/dL, which represents a 12.99% decrease in renal function from baseline (preoperative creatinine 0.823 mg/dL, estimated glomerular filtration rate = 93.9 mL/min/1.73 m(2) ).	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	199-204
27496426-7	2016	Analysis of the rs2630578 BICD1 gene polymorphism genotypes revealed statistically significant differences in long-term creatinine concentrations.	Creatinine	120-130	BICD cargo adaptor 1	Homo sapiens	26-31
27080317-6	2016	Urinary C-peptide creatinine ratio (UCPCR) measures endogenous insulin production.	Creatinine	18-28	insulin	Homo sapiens	63-70
26055553-4	2016	Compared with CCR5+/+ mice, CCR5-/- mice showed increased mortality and renal injury, including elevated creatinine and blood urea nitrogen levels, following LPS challenge.	Creatinine	105-115	chemokine (C-C motif) receptor 5	Mus musculus	28-32
26626599-7	2016	The mean levels of BP-1, BP-3, and 4-OH-BP were 0.87, 5.87, and 0.13 ng/g creatinine, respectively.	Creatinine	74-84	BP1	Homo sapiens	19-29
27275161-6	2016	RESULTS: PlGF and sFlt-1 levels were significantly correlated with the dialysate-to-plasma ratio of creatinine (r = 0.342, p = 0.04 and r = 0.554, p &lt; 0.001) although PlGF and sFlt-1 levels were not correlated with total creatinine clearance and total Kt/V.	Creatinine	100-110	placental growth factor	Homo sapiens	9-13
27275161-6	2016	RESULTS: PlGF and sFlt-1 levels were significantly correlated with the dialysate-to-plasma ratio of creatinine (r = 0.342, p = 0.04 and r = 0.554, p &lt; 0.001) although PlGF and sFlt-1 levels were not correlated with total creatinine clearance and total Kt/V.	Creatinine	224-234	placental growth factor	Homo sapiens	9-13
26471129-5	2016	However, after renal ischemia-reperfusion injury, Klf4 cKO mice exhibited elevated serum levels of urea nitrogen and creatinine and aggravated renal histology compared with those of Klf4 floxed controls.	Creatinine	117-127	Kruppel-like factor 4 (gut)	Mus musculus	50-54
26948921-9	2016	Serum anti-MPO antibody was correlated significantly with decrease in visual acuity (F=48.40, p&lt;0.001), increase in serum urea (F=128.13, p&lt;0.001) and creatinine (F=77.10, p&lt;0.001).	Creatinine	157-167	myeloperoxidase	Homo sapiens	11-14
27016778-8	2016	PlGF serum concentrations positively correlated with urinary tetrahydroaldosterone corrected for creatinine in these two independent cohorts.	Creatinine	97-107	placental growth factor	Homo sapiens	0-4
26831744-6	2016	There were no significant differences in rates of HTN or left ventricular hypertrophy, but subjects with ARPKD had a greater percent on &gt;= 3 blood pressure medications (32% vs 0%, P &lt; .0001), more angiotensin-converting enzyme inhibitor use (82% vs 27% vs 36%, P &lt; .0005), and less proteinuria (urine protein: creatinine = 0.1 vs 0.6, P &lt; .005).	Creatinine	319-329	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	105-110
27196444-4	2016	Laboratory tests showed serum creatinine at 2.3 mg/dL with an estimated glomerular filtration rate of 26 mL/min/1.73m, and gamma-glutamyl transpeptidase and alkaline phosphatase at 3 and 1.5 times the upper normal limit.	Creatinine	30-40	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
27093923-7	2016	Consistent with the in vitro data, low NLRP3 mRNA expression in kidney biopsies was associated with a linear trend of higher risk of composite endpoint of doubling serum creatinine and end stage renal disease in patients with IgAN.	Creatinine	170-180	NLR family pyrin domain containing 3	Homo sapiens	39-44
26916537-7	2016	Participants with higher proENK levels were older and had higher serum creatinine and lower estimated glomerular filtration rate, lower ejection fraction, and higher rates of hypertension and diabetes (p &lt;=0.009).	Creatinine	71-81	proenkephalin	Homo sapiens	25-31
27114803-8	2016	RESULTS: Our results revealed that transplantation of Nrf2-overexpressed MSCs into AKI-induced rats decreased blood urea nitrogen and creatinine and ameliorated kidney regeneration throughout 14 days.	Creatinine	134-144	NFE2 like bZIP transcription factor 2	Rattus norvegicus	54-58
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	44-54	interleukin 6	Homo sapiens	188-192
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	56-58	interleukin 6	Homo sapiens	188-192
27605722-14	2016	Serum creatinine, BMI, triglyceride and atherogenic index of plasma correlated positively with CRP.	Creatinine	6-16	C-reactive protein	Homo sapiens	95-98
26438387-11	2016	Polymorphisms of CLNK also affected levels of albumin, triglycerides, and creatinine.	Creatinine	74-84	cytokine dependent hematopoietic cell linker	Homo sapiens	17-21
26928779-10	2016	In the human ATCMR cases, the group with higher MCP expression in the grafts showed improved serum creatinine levels after the ATCMR treatment as well as a better 5-year graft survival rate.	Creatinine	99-109	CD46 molecule	Homo sapiens	48-51
26268515-9	2016	Four months after consolidation, urine fetuin-A directly correlated with serum creatinine (r = 0.54, P = 0.004) and inversely correlated with the eGFR (r = -0.66, P &lt; 0.0001).	Creatinine	79-89	alpha 2-HS glycoprotein	Homo sapiens	39-47
27051593-7	2016	The CD89xTG2 formula had a high ability to discriminate active from inactive IgAN/HSPN in both situations: CD89xTG2/proteinuria ratio (AUC: 0.84, P &lt; 0.001, sensitivity: 76%, specificity: 74%) and CD89xTG2/urinary creatinine ratio (AUC: 0.82, P &lt; 0.001, sensitivity: 75%, specificity: 74%).	Creatinine	217-227	Fc alpha receptor	Homo sapiens	4-12
27051593-7	2016	The CD89xTG2 formula had a high ability to discriminate active from inactive IgAN/HSPN in both situations: CD89xTG2/proteinuria ratio (AUC: 0.84, P &lt; 0.001, sensitivity: 76%, specificity: 74%) and CD89xTG2/urinary creatinine ratio (AUC: 0.82, P &lt; 0.001, sensitivity: 75%, specificity: 74%).	Creatinine	217-227	Fc alpha receptor	Homo sapiens	107-115
27051593-7	2016	The CD89xTG2 formula had a high ability to discriminate active from inactive IgAN/HSPN in both situations: CD89xTG2/proteinuria ratio (AUC: 0.84, P &lt; 0.001, sensitivity: 76%, specificity: 74%) and CD89xTG2/urinary creatinine ratio (AUC: 0.82, P &lt; 0.001, sensitivity: 75%, specificity: 74%).	Creatinine	217-227	Fc alpha receptor	Homo sapiens	107-115
26863224-7	2016	C18 ceramide is correlated to bilirubin, INR, and creatinine after transplant in DCD.	Creatinine	50-60	Bardet-Biedl syndrome 9	Homo sapiens	0-3
26798476-8	2016	RESULTS: Patients with IGF-1 levels in the lowest tertile were characterized by female sex, low creatinine, hypoalbuminemia and high C-reactive protein (CRP) levels.	Creatinine	96-106	insulin like growth factor 1	Homo sapiens	23-28
26668020-1	2016	BACKGROUND AND OBJECTIVES: eGFR on the basis of creatinine (eGFRcre) associates differently with cardiovascular disease and mortality than eGFR on the basis of cystatin C (eGFRcys).	Creatinine	48-58	epidermal growth factor receptor	Homo sapiens	27-31
26668020-1	2016	BACKGROUND AND OBJECTIVES: eGFR on the basis of creatinine (eGFRcre) associates differently with cardiovascular disease and mortality than eGFR on the basis of cystatin C (eGFRcys).	Creatinine	48-58	epidermal growth factor receptor	Homo sapiens	60-64
26668020-2	2016	This may be related to risk factors affecting the level of creatinine and cystatin C along non-GFR pathways, which may confound the association between eGFR and outcome.	Creatinine	59-69	epidermal growth factor receptor	Homo sapiens	152-156
26837280-2	2016	We demonstrated that plasma miR-130b downregulation exhibited clinical and biological relevance as it was linked to increased serum creatinine, beta2-microglobulin and proteinuria, increased Snail expression and tubulointerstitial fibrosis in renal biopsies of DN patients.	Creatinine	132-142	microRNA 130b	Homo sapiens	28-36
26909149-8	2016	Serum sclerostin levels were positively correlated with age (P&lt;0.001), body mass index (BMI) (P=0.01) and lumbar spine Z-score (P=0.001) and negatively with creatinine clearance (P=0.001).	Creatinine	160-170	sclerostin	Homo sapiens	6-16
26420894-5	2016	Genome-wide association studies were conducted to relate the SNPs to creatinine-based estimated glomerular filtration rate (eGFR crea) and proteinuria (urinary albumin- or protein-to-creatinine ratio &gt;= 300 and &gt;= 500 mg/g, respectively).	Creatinine	69-79	epidermal growth factor receptor	Homo sapiens	124-128
26784512-5	2016	The ABCB1 3435 CC genotype in donor was significantly associated with lower estimated glomerular filtration in recipients within 1 month (p &lt; 0.05) and correlated with delayed creatinine recovery (p = 0.007).	Creatinine	179-189	ATP binding cassette subfamily B member 1	Homo sapiens	4-9
26784512-6	2016	CONCLUSIONS: ABCB1 3435 CC genotype in donor influences early renal function and creatinine recovery in tacrolimus-treated kidney transplant recipients.	Creatinine	81-91	ATP binding cassette subfamily B member 1	Homo sapiens	13-18
26820468-7	2016	We observed that plasma creatinine levels were increased in Pla2g5-/- mice following by a decrease in creatinine clearance.	Creatinine	24-34	phospholipase A2, group V	Mus musculus	60-66
26725683-5	2016	RANTES deficient (RANTES(-/-)) mice showed better renal function by reducing the acute tubular necrosis, serum creatinine levels, infiltration of inflammatory cells and cytokine expressions compared to wild type.	Creatinine	111-121	chemokine (C-C motif) ligand 5	Mus musculus	0-6
26780111-9	2016	Probability of survival is found to be significantly reduced where AST &gt;1130U/l, ALT &gt;490U/l, CPK &gt;505U/l, LDH &gt;980U/l, platelet count &lt;23x10(3)/l, creatinine &gt;1.4mg/dl, INR &gt;1.3, d-dimer &gt;7100ng/dl, and viral load &gt;1.03x10(8)copy/ml.	Creatinine	163-173	solute carrier family 17 member 5	Homo sapiens	67-70
26725683-5	2016	RANTES deficient (RANTES(-/-)) mice showed better renal function by reducing the acute tubular necrosis, serum creatinine levels, infiltration of inflammatory cells and cytokine expressions compared to wild type.	Creatinine	111-121	chemokine (C-C motif) ligand 5	Mus musculus	18-24
27268630-10	2016	MVD showed a significant positive correlation with blood urea, lactate dehydrogenase, serum creatinine, beta2 microglobulin and skeletal lesions.	Creatinine	92-102	mevalonate diphosphate decarboxylase	Homo sapiens	0-3
26454686-9	2016	RESULTS: Mean iohexol, iothalamate, and creatinine clearances were 52+-28 (SD), 60+-34, and 74+-40 mL/min/1.73 m(2), respectively.	Creatinine	40-50	CD59 molecule (CD59 blood group)	Homo sapiens	102-107
26635084-5	2016	Urinary podocalyxin levels were also significantly related to albumin-to-creatinine ratio.	Creatinine	73-83	podocalyxin like	Homo sapiens	8-19
27847811-10	2016	There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values" p = 0.049, 0.01, and 0.004, resp.).	Creatinine	144-154	fatty acid binding protein 1	Sus scrofa	166-172
27833443-12	2016	The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1.	Creatinine	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
27833443-12	2016	The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1.	Creatinine	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
27594733-7	2016	There was positive correlation between NAG/Cr and Alb/Cr (r = 0.49, p &lt; 0.001) and between NAG/Cr and serum creatinine (r = 0.441, p &lt; 0.001).	Creatinine	43-45	albumin	Homo sapiens	50-53
27594733-8	2016	A negative correlation was found between NAG/Cr and eGFR (r = -0.432, p &lt; 0.05).	Creatinine	45-47	epidermal growth factor receptor	Homo sapiens	52-56
27433370-3	2016	The urinary neopterin/creatinine ratio can quantify the systemic interferon-gamma effect in patients with M. tuberculosis infection.	Creatinine	22-32	interferon gamma	Homo sapiens	65-81
27593903-4	2016	The proportion of patients was evaluated in each creatinine-calculated eGFR category for which the category was reclassified based on either cystatin C or the combined measurement.	Creatinine	49-59	epidermal growth factor receptor	Homo sapiens	71-75
26602114-4	2016	Early diagnosis of microalbuminuria (30-300 mg/24 h urine albumin excretion or 30-300 mg/g creatinine in random collections) has prognostic value for monitoring disease progression and early clinical management of diabetic nephropathy in prediabetic patients.	Creatinine	91-101	albumin	Homo sapiens	24-31
26411359-10	2016	The positive rates of beta1-AABs in patients with abnormal blood level of Cr, eGFR, Cys-C, and NGAL were significantly higher than those with normal levels (P = 0.03, P = 0.02, P = 0.001, P = 0.007, respectively).	Creatinine	74-76	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	22-27
26627016-3	2016	In CKD, interleukin-6 and hypersensitive C-reactive protein are known to be used for the evaluation of inflammation and serum levels increase with decreased creatinine clearance.	Creatinine	157-167	interleukin 6	Homo sapiens	8-21
26627016-3	2016	In CKD, interleukin-6 and hypersensitive C-reactive protein are known to be used for the evaluation of inflammation and serum levels increase with decreased creatinine clearance.	Creatinine	157-167	C-reactive protein	Homo sapiens	41-59
26707134-1	2016	BACKGROUND: Recently, it has been reported that urinary angiotensinogen levels is a specific index of the intrarenal renin-angiotensin-aldosterone system (RAAS) status and it is significantly correlated with urinary albumin:creatinine (Cr) ratio in hypertensive patients.	Creatinine	224-234	angiotensinogen	Homo sapiens	56-71
26130680-7	2016	Blockade of the endothelin 1 receptor A significantly decreased hypertension (P = .001), circulating endothelin 1, and interleukin 17 (P = .004 and .003), placental preproendothelin mRNA expression (P = .016), and urinary protein:creatinine ratio (P = .007) in rats with hemolysis-elevated liver enzymes-low platelet syndrome.	Creatinine	230-240	endothelin 1	Rattus norvegicus	16-28
27801416-12	2016	There was also a direct correlation of urinary podocin concentrations with blood creatinine levels (r=0.35; p&lt;0.05) and that of NGAL with albuminuria (r=0.35; p&lt;0.05) in recipients after transplantation.	Creatinine	81-91	NPHS2 stomatin family member, podocin	Homo sapiens	47-54
26915869-7	2016	The negative correlations between TGF-beta1 and creatinine and AST achieved statistical significance (P &lt; .05).	Creatinine	48-58	transforming growth factor beta 1	Homo sapiens	34-43
26915869-7	2016	The negative correlations between TGF-beta1 and creatinine and AST achieved statistical significance (P &lt; .05).	Creatinine	48-58	solute carrier family 17 member 5	Homo sapiens	63-66
26450935-5	2015	Two primary outcomes were development of urinary albumin excretion &gt;30 mg/24 h and eGFR (creatinine/cystatin C-based CKD Epidemiology Collaboration) &lt;60 ml/min per 1.73 m(2).	Creatinine	92-102	epidermal growth factor receptor	Homo sapiens	86-90
26014304-4	2015	Acute kidney injury was diagnosed within three days of life when the creatinine clearance was &lt;=16 mL/min/1.73 m2.	Creatinine	69-79	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
26790786-4	2015	Increased postoperative serum creatinine was considered indicative of postoperative renal injury according to RIFLE criteria.	Creatinine	30-40	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	110-115
26669781-10	2015	Urinary [TIMP-2]*[IGFBP7] increased significantly as early as 4 h after CABG in patients with AKI 2/3 (1.83 +- 2.15 vs. 0.23 +- 0.45, p &lt; 0.05) whereas serum creatinine did not increase until 48 h after surgery.	Creatinine	161-171	insulin like growth factor binding protein 7	Homo sapiens	18-24
26627205-5	2015	RESULTS: Creatinine-based equations generally overestimated GFR in patients with cirrhosis and showed a bias (average difference between mGFR and eGFR) of -40 (CG), -12 (MDRD) and -9 (CKD-EPI-Cr) ml/min/1.73 m(2).	Creatinine	9-19	epidermal growth factor receptor	Homo sapiens	146-150
26881255-0	2016	The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio.	Creatinine	109-119	microRNA 192	Homo sapiens	18-25
26881255-9	2016	CONCLUSIONS: These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.	Creatinine	120-130	microRNA 192	Homo sapiens	56-63
26881255-9	2016	CONCLUSIONS: These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.	Creatinine	120-130	microRNA 192	Homo sapiens	172-179
27083170-6	2016	Urine C-peptide creatinine ratio measured in a single post stimulated sample has been shown to be a robust, reproducible measure of endogenous C-peptide which is stable for three days at room temperature when collected in boric acid.	Creatinine	16-26	insulin	Homo sapiens	6-15
27083170-6	2016	Urine C-peptide creatinine ratio measured in a single post stimulated sample has been shown to be a robust, reproducible measure of endogenous C-peptide which is stable for three days at room temperature when collected in boric acid.	Creatinine	16-26	insulin	Homo sapiens	143-152
26627016-9	2016	In patient groups, while hepcidin, NGAL, interleukin-6, hypersensitive C-reactive protein levels were correlated with creatinine and glomerular filtration rate, iron metabolism parameters were not correlated with the inflammation biomarkers.	Creatinine	118-128	C-reactive protein	Homo sapiens	71-89
27486379-7	2015	In CCl4 treated rats the results showed significant (p&lt;0.05) increases in serum Na+, K+, Cl(-), urea and creatinine.	Creatinine	108-118	C-C motif chemokine ligand 4	Rattus norvegicus	3-7
26509856-0	2015	COMBINING CREATININE-BASED eGFR WITH CYSTATIN C-BASED EGFR TO BETTER ASSESS RENAL FUNCTION IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE 3A: IMPLICATIONS FOR DRUG SELECTION AND DOSAGE IN TYPE 2 DIABETES.	Creatinine	10-20	epidermal growth factor receptor	Homo sapiens	27-31
26116142-8	2015	Furthermore, urinary angiotensinogen was significantly increased in neonates with a urinary cystatin-C-to-creatinine ratio &gt;=2500 ng/mg, which was the optimal cut-off value to predict acute kidney injury in our previous study.	Creatinine	106-116	angiotensinogen	Homo sapiens	21-36
26444029-2	2015	Insulin resistance is common in patients with end-stage renal disease but also occurs in patients with chronic kidney disease (CKD), even when the serum creatinine is minimally increased.	Creatinine	153-163	insulin	Homo sapiens	0-7
26427353-5	2015	Before the appearance of the tentative symptoms of renal failure, which is apparent by morphological damage in the kidney and increases in blood creatinine levels, both the expression level and activity of TG1 rapidly increased mainly at the proximal tubule.	Creatinine	145-155	triglyceride level 1	Mus musculus	206-209
27493857-7	2015	The pilot study showed that the urinary adiponectin levels, which were corrected by the creatinine concentration, were 0.73+-0.50 (ng/mg creatinine, N=6) for healthy subjects, versus 12.02+-3.85 (ng/mg creatinine, N=3) for patients with diabetes mellitus (DM).	Creatinine	88-98	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
27493857-7	2015	The pilot study showed that the urinary adiponectin levels, which were corrected by the creatinine concentration, were 0.73+-0.50 (ng/mg creatinine, N=6) for healthy subjects, versus 12.02+-3.85 (ng/mg creatinine, N=3) for patients with diabetes mellitus (DM).	Creatinine	137-147	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
27493857-7	2015	The pilot study showed that the urinary adiponectin levels, which were corrected by the creatinine concentration, were 0.73+-0.50 (ng/mg creatinine, N=6) for healthy subjects, versus 12.02+-3.85 (ng/mg creatinine, N=3) for patients with diabetes mellitus (DM).	Creatinine	137-147	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
26742964-9	2015	Ratio of urinary HER2/neu to urinary creatinine was significantly higher in group 2 than group 1, (p=0,021).	Creatinine	37-47	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
26742964-11	2015	HER2/neu, the sensitivity of the test was found to be 20.5%, and the specificity was 97.5%, also for the urinary HER2/neu/urinary creatinine ratio, the sensitivity and specificity of the test were found to be 31.8% and 87.5%, respectively.	Creatinine	130-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
26742964-11	2015	HER2/neu, the sensitivity of the test was found to be 20.5%, and the specificity was 97.5%, also for the urinary HER2/neu/urinary creatinine ratio, the sensitivity and specificity of the test were found to be 31.8% and 87.5%, respectively.	Creatinine	130-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
26823757-2	2015	According to the etiology, Sepsis-induced AKI (SAKI) is a leading contributor to AKI and significantly has very poor prognosis, which might be related to the late detection when the elevation of BUN and serum creatinine (SCr) is used.	Creatinine	209-219	NOP2/Sun RNA methyltransferase 2	Homo sapiens	47-51
26823757-5	2015	Therefore, extensive research efforts over this past decade have been directed at the discovery and validation of novel SAKI biomarkers to detect injury prior to changes in kidney function, a number of serum and urinary proteins, including NGAL, KIM-1, cystatin-C, IL-18, and L-FABP, have been identified for predicting SAKI before a rise in BUN and serum creatinine in several experimental and clinical trainings.	Creatinine	356-366	NOP2/Sun RNA methyltransferase 2	Homo sapiens	120-124
26793755-1	2015	Glomerular filtration rate (eGFR) by serum creatinine (eGFRCr) or standardized cystatin C (eGFRCysC) were estimated in Japanese patients with Graves  disease (GD) of different sex.	Creatinine	43-53	epidermal growth factor receptor	Homo sapiens	28-32
25883071-1	2015	The development and widespread use of serum creatinine concentration-based prediction equations to calculate eGFR have been major advances for detection of patients with CKD and the epidemiologic study of CKD and its outcomes.	Creatinine	44-54	epidermal growth factor receptor	Homo sapiens	109-113
26342047-6	2015	Kinetic eGFR was calculated on day 1 according to serum creatinine evolution.	Creatinine	56-66	epidermal growth factor receptor	Homo sapiens	8-12
26509856-0	2015	COMBINING CREATININE-BASED eGFR WITH CYSTATIN C-BASED EGFR TO BETTER ASSESS RENAL FUNCTION IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE 3A: IMPLICATIONS FOR DRUG SELECTION AND DOSAGE IN TYPE 2 DIABETES.	Creatinine	10-20	epidermal growth factor receptor	Homo sapiens	54-58
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Creatinine	312-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26823823-7	2015	Meanwhile, during the follow-up, the urine protein, mean serum creatinine and eGFR in patients with positive PKC were all higher than those in negative expression group (P &lt; 0.05).	Creatinine	63-73	proline rich transmembrane protein 2	Homo sapiens	109-112
26131743-7	2015	Furthermore, DNA autoantibody production, proteinuria, and serum creatinine levels were significantly lower in the anti-IL-3 group.	Creatinine	65-75	interleukin 3	Mus musculus	120-124
26115618-7	2015	Serum adiponectin (baseline mean 14.3 +- 6.6 mug/ml) and urine adiponectin:creatinine (Uadp/cr) (baseline mean 126.8 +- 178.9 mug/ml) directly correlated with proteinuria at all time points (r = 0.37-0.81; all p &lt; 0.05).	Creatinine	75-85	adiponectin, C1Q and collagen domain containing	Homo sapiens	63-74
26680048-2	2015	OBJECTIVE: The objective of this study was to compare the direct measurement of glomerular filtration rate (GFR) using EDTA-Cr51 and the estimations based on creatinine (eGFR): Cr clearance (CCr) with 24-hour urine and estimated using Cockroft-Gault (adjusted by using body surface area-Mosteller formula-SC), MDRD-4, MDRD-6, and CKD-EPI to determine the usefulness of different methods from EDTA-Cr51to evaluate the kidney function.	Creatinine	158-168	epidermal growth factor receptor	Homo sapiens	170-174
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Creatinine	312-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
25877916-8	2015	Our data suggest that the widely used estimated baseline creatinine clearance value of 120 mL/min/1.73 m(2) underestimates actual baseline function in patients admitted to paediatric intensive care units.	Creatinine	57-67	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
26255708-5	2015	The glomerular filtration rate was estimated (eGFR) using serum creatinine and cystatin C concentrations.	Creatinine	64-74	epidermal growth factor receptor	Homo sapiens	46-50
26870118-3	2015	AKI was defined according to RIFLE criteria with sudden rise in creatinine or decline in urine output or both.	Creatinine	64-74	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	29-34
26198480-7	2015	Genetic deletion of NLRP3 reversed the CLP-induced reduction in blood pressure and increases in serum creatinine level and neutrophil infiltration, and attenuated the CLP-induced upregulation of apoptosis-associated speck-like protein, caspase-1 expression and activity, and the secretion of IL-1beta and IL-18, similarly to the effects of caspase-1 inhibition.	Creatinine	102-112	NLR family pyrin domain containing 3	Homo sapiens	20-25
26061548-4	2015	Compared to vehicle-treated mice, blockade of TNF-alpha with a murine anti-TNF-alpha antibody conferred kidney protection in Ins2(Akita) mice as indicated by reductions in albuminuria, plasma creatinine, histopathologic changes, kidney macrophage recruitment, and plasma inflammatory cytokine levels at 18 weeks of age.	Creatinine	192-202	tumor necrosis factor	Mus musculus	46-55
26061548-4	2015	Compared to vehicle-treated mice, blockade of TNF-alpha with a murine anti-TNF-alpha antibody conferred kidney protection in Ins2(Akita) mice as indicated by reductions in albuminuria, plasma creatinine, histopathologic changes, kidney macrophage recruitment, and plasma inflammatory cytokine levels at 18 weeks of age.	Creatinine	192-202	tumor necrosis factor	Mus musculus	75-84
26061548-6	2015	Conditional ablation of TNF-alpha in macrophages significantly reduced albuminuria, the increase in plasma creatinine and blood urea nitrogen, histopathologic changes, and kidney macrophage recruitment compared to diabetic TNF-alpha(Flox/Flox) control mice after 12 weeks of streptozotocin-induced diabetes.	Creatinine	107-117	tumor necrosis factor	Mus musculus	24-33
26435827-12	2015	The study revealed significant positive correlation of hemostatic factors (TM, vWf, PAI-1 &amp; t-PA) with creatinine, urea, hsCRP &amp; CIMT.	Creatinine	107-117	von Willebrand factor	Homo sapiens	79-82
26399271-10	2015	MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores.	Creatinine	59-69	TIMP metallopeptidase inhibitor 1	Homo sapiens	24-30
26628791-10	2015	In conclusion, u-LFABP levels were elevated in patients with reduced eGFR and showed a positive correlation with systolic blood pressure and protein to creatinine ratio in the total study subjects.	Creatinine	152-162	fatty acid binding protein 1	Homo sapiens	17-22
25134440-5	2015	METHODS: AKI was defined by RIFLE criteria as an increase in serum creatinine greater than or equal to 50% from the reference creatinine.	Creatinine	67-77	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	28-33
26831550-9	2015	The pre-treatment urine albumin: creatinine ratio was positively correlated with pre-treatment MIG levels (r=0.41, p&lt;0.05).	Creatinine	33-43	C-X-C motif chemokine ligand 9	Homo sapiens	95-98
26013249-5	2015	Plasma creatinine level was used to measure the estimated glomerular filtration rate ([eGFR] by Modification of Diet in Renal Disease equation).	Creatinine	7-17	epidermal growth factor receptor	Homo sapiens	87-91
26013249-10	2015	Creatinine inversely correlated with CD4 (r = -.228, P = .025).	Creatinine	0-10	CD4 molecule	Homo sapiens	37-40
26013249-11	2015	CD4 predicts creatinine (odds ratio 1.6, 95% confidence interval 1.0-1.8, P = .003).	Creatinine	13-23	CD4 molecule	Homo sapiens	0-3
25830762-7	2015	These relationships persisted after adjustment for change in serum creatinine (for first postoperative log(H-FABP)) and biomarkers of cardiac and kidney injury, including brain natriuretic peptide, cardiac troponin-I, interleukin-18, liver fatty acid binding protein, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin.	Creatinine	67-77	fatty acid binding protein 3	Homo sapiens	107-113
26123683-8	2015	Urine vascular endothelial growth factor concentration was determined using enzyme-linked immunosorbant assay and creatinine-corrected.	Creatinine	114-124	vascular endothelial growth factor A	Homo sapiens	6-40
25934442-8	2015	RESULTS: Among urinary biomarkers only angiotensinogen in patients with scarring (median 14.6 mug/gm creatinine) demonstrated significantly higher levels than in patients without scarring (3.6 mug/gm creatinine, p &lt;0.001).	Creatinine	101-111	angiotensinogen	Homo sapiens	39-54
25934442-8	2015	RESULTS: Among urinary biomarkers only angiotensinogen in patients with scarring (median 14.6 mug/gm creatinine) demonstrated significantly higher levels than in patients without scarring (3.6 mug/gm creatinine, p &lt;0.001).	Creatinine	200-210	angiotensinogen	Homo sapiens	39-54
26416975-5	2015	Furthermore, 4 weeks after 5/6 nephrectomy with continuous low-dose angiotensin II infusion, C3HeOuJ (TLR4 WT) mice developed progressive CKD with albuminuria, increased serum levels of BUN and creatinine, glomerulosclerosis, and interstitial fibrosis, whereas TLR4 mutant mice were significantly protected from CKD progression.	Creatinine	194-204	toll-like receptor 4	Mus musculus	102-106
26832708-7	2015	And compared to the control group, activity of serum alanine aminotransferase (ALT) and aspartic acid transaminase (AST) decreased significantly in group of paraquat poisoning with triple application of SB, the level of serum urea nitrogen (BUN) and creatinine (Cr) significantly decreased, the difference is statistically significant (P&lt;0.01).	Creatinine	250-260	solute carrier family 17 member 5	Homo sapiens	116-119
26832708-7	2015	And compared to the control group, activity of serum alanine aminotransferase (ALT) and aspartic acid transaminase (AST) decreased significantly in group of paraquat poisoning with triple application of SB, the level of serum urea nitrogen (BUN) and creatinine (Cr) significantly decreased, the difference is statistically significant (P&lt;0.01).	Creatinine	262-264	solute carrier family 17 member 5	Homo sapiens	116-119
26361683-4	2015	The patient had a remarkable response to adrenocorticotropic hormone (ACTH) gel and achieved complete remission (UPCR, 0.5; serum albumin, 4.1 g/dL; serum creatinine, 1.0 mg/dL) which was maintained over 10 months on this treatment.	Creatinine	155-165	proopiomelanocortin	Homo sapiens	70-74
25281008-1	2015	BACKGROUND: We reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine.	Creatinine	158-168	albumin	Homo sapiens	40-47
26270596-0	2015	Reactivity of Hydride Bridges in High-Spin [3M-3(mu-H)] Clusters (M = FeII, CoII).	Creatinine	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
26316797-8	2015	The difference in urinary L-FABP levels (DeltaL-FABP &gt;=11.0 mug/g creatinine) between before CCP and at 24 hours after CCP was a risk factor for the occurrence of cardiovascular events (hazard ratio, 4.93; 95% confidence interval, 1.27-19.13; P=0.021).	Creatinine	69-79	fatty acid binding protein 1	Homo sapiens	26-32
26301504-4	2015	METHODS: We examined the association between the urine albumin/creatinine ratio (UACR) and hs-cTnT levels in 1354 participants without overt cardiovascular disease in a community-based, cross-sectional study in Beijing, China.	Creatinine	63-73	troponin T2, cardiac type	Homo sapiens	94-98
25281008-1	2015	BACKGROUND: We reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine.	Creatinine	158-168	albumin	Homo sapiens	49-52
25281008-1	2015	BACKGROUND: We reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine.	Creatinine	158-168	albumin	Homo sapiens	67-74
25326724-1	2015	BACKGROUND: The present study was performed to determine the reference values of glomerular filtration rate (GFR) in children by age using the new eGFR equations derived from serum creatinine (Cr) and cystatine C (cysC).	Creatinine	181-191	epidermal growth factor receptor	Homo sapiens	147-151
25977070-7	2015	RESULTS: At the population level, 17,113 cTnT and creatinine measurements from 10,418 patients demonstrated rising cTnT with falling eGFR, with no eGFR threshold for this effect.	Creatinine	50-60	troponin T2, cardiac type	Homo sapiens	115-119
25977070-10	2015	Within individuals, the magnitude of changes in cTnT approximated 33% of changes in creatinine.	Creatinine	84-94	troponin T2, cardiac type	Homo sapiens	48-52
25977070-12	2015	The modest association between changes in cTnT and creatinine within individuals in the short term further highlights the need for caution when interpreting troponin elevations in this setting.	Creatinine	51-61	troponin T2, cardiac type	Homo sapiens	42-46
26193292-7	2015	Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP.	Creatinine	130-140	C-reactive protein	Homo sapiens	178-181
25648880-7	2015	Glomerular IFN-gamma and IL-17 staining grades correlated with the urinary protein/creatinine ratio (r = 0.62, p = 0.02 and r = 0.507, p = 0.016, respectively).	Creatinine	83-93	interferon gamma	Homo sapiens	11-20
25651307-11	2015	The urine level of trp 2 weeks after transplantation predicted the serum creatinine 6 months and the estimated creatinine clearance 2 years after transplantation.	Creatinine	73-83	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	19-24
25651307-11	2015	The urine level of trp 2 weeks after transplantation predicted the serum creatinine 6 months and the estimated creatinine clearance 2 years after transplantation.	Creatinine	111-121	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	19-24
26187318-4	2015	IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine.	Creatinine	168-178	interleukin 6	Homo sapiens	0-4
26187318-4	2015	IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine.	Creatinine	168-178	C-reactive protein	Homo sapiens	9-12
25647584-7	2015	Moreover, serum DcR3 levels were closely related to the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and parameters reflecting kidney injury including BUN, creatinine (Cr) and proteinuria.	Creatinine	188-198	TNF receptor superfamily member 6b	Homo sapiens	16-20
25647584-7	2015	Moreover, serum DcR3 levels were closely related to the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and parameters reflecting kidney injury including BUN, creatinine (Cr) and proteinuria.	Creatinine	200-202	TNF receptor superfamily member 6b	Homo sapiens	16-20
26066674-10	2015	In men (n = 691), positive correlations between me-NAM and fasting glucose, low-density lipoprotein, liver function, and serum creatinine levels were also observed in both simple and multivariate adjusted correlation analyses.	Creatinine	127-137	SH3 and cysteine rich domain 3	Homo sapiens	51-54
26107422-7	2015	Subjects showing the expected fall in EPO demonstrated a higher increase in creatinine clearance, similar to that observed in control subjects.	Creatinine	76-86	erythropoietin	Homo sapiens	38-41
26200468-9	2015	Multivariate analyses failed to reveal any correctable clinical features associated with postoperative uNGAL changes, whereas preoperative serum creatinine levels and the onset of AKI correlated with eGFR at 6 months postoperatively.	Creatinine	145-155	epidermal growth factor receptor	Homo sapiens	200-204
26126806-6	2015	However, an increased risk of graft loss (relative risk (RR) = 1.20) and inferior graft function (creatinine clearance, weighted mean difference (WMD) = -2.41 mumol/L) were demonstrated in mTOR-I-treated patients.	Creatinine	98-108	mechanistic target of rapamycin kinase	Homo sapiens	189-193
25901093-5	2015	The annual rate of change in the eGFR was calculated in 4940 participants using creatinine measurements during the in-trial period and classified into quintiles (Q) on the basis of the following eGFR changes: rapid decline (Q1), decline (Q2), stable (Q3), increase (Q4), and rapid increase (Q5).	Creatinine	80-90	epidermal growth factor receptor	Homo sapiens	33-37
25384728-9	2015	CONCLUSIONS: These results suggest that IL6-174G&gt;C may contribute to T1DM and increased albumin-to-creatinine ratio as well as to poor glycemic control and hyperlipidemia.	Creatinine	102-112	interleukin 6	Homo sapiens	40-43
25857767-6	2015	RESULTS: Renal filtration function (eGFR) declined and urinary albumin-to-creatinine ratio (ACR) levels increased progressively with the increase in plasma VCAM-1 levels.	Creatinine	74-84	vascular cell adhesion molecule 1	Homo sapiens	156-162
26314441-12	2015	The grade II serum creatinine was elevated in 2 cases of ASP+CHOP group and in 1 case of CHOP group who was inproved after symptomatic therapy.	Creatinine	19-29	DNA damage inducible transcript 3	Homo sapiens	61-65
26314441-12	2015	The grade II serum creatinine was elevated in 2 cases of ASP+CHOP group and in 1 case of CHOP group who was inproved after symptomatic therapy.	Creatinine	19-29	DNA damage inducible transcript 3	Homo sapiens	89-93
26393116-13	2015	MPO had a positive correlation with creatinine and urine protein-creatinine ratio in Nephrotic syndrome.	Creatinine	36-46	myeloperoxidase	Homo sapiens	0-3
26393116-13	2015	MPO had a positive correlation with creatinine and urine protein-creatinine ratio in Nephrotic syndrome.	Creatinine	65-75	myeloperoxidase	Homo sapiens	0-3
25956757-5	2015	Urine podocyte (podocin) mRNA expressed in relation to either urine creatinine concentration or a kidney tubular marker (aquaporin 2) was tested as markers.	Creatinine	68-78	NPHS2 stomatin family member, podocin	Homo sapiens	16-23
26112018-7	2015	The presence of the two-risk allele increased serum creatinine with a corresponding reduction in eGFR (either MDRD or CKD-EPI based).	Creatinine	52-62	epidermal growth factor receptor	Homo sapiens	97-101
26088750-9	2015	Expression of SLLP1 was associated with adverse cytogenetics and with negative prognostic factors including the patient"s age, number of BM-infiltrating plasma cells, serum albumin, beta2-microglobulin, creatinine, and hemoglobin.	Creatinine	203-213	sperm acrosome associated 3	Homo sapiens	14-19
26092580-0	2015	Increased urinary Angiotensinogen/Creatinine (AGT/Cr) ratio may be associated with reduced renal function in autosomal dominant polycystic kidney disease patients.	Creatinine	34-44	angiotensinogen	Homo sapiens	46-49
25825481-1	2015	BACKGROUND AND OBJECTIVES: Kidney disease progression, assessed by change in eGFR on the basis of creatinine, is an independent risk factor for cardiovascular disease and death.	Creatinine	98-108	epidermal growth factor receptor	Homo sapiens	77-81
25825481-6	2015	Cox regression models were adjusted for established risk factors for cardiovascular disease and mortality and first measurement of eGFR on the basis of creatinine.	Creatinine	152-162	epidermal growth factor receptor	Homo sapiens	131-135
26194833-11	2015	After modeling of 2 h, AMS, BUN and CR in group B increased significantly and reached the peak value at 6 h. After modeling of 12 h, serum level of TNF-alpha and IL-6 were significantly lower than that of in control group, while after 24 h of modeling, serum level of AMS, BUN, CR, TNF-alpha and IL-6 were significantly lower than that of in control group (P &lt; 0.05).	Creatinine	278-280	tumor necrosis factor	Rattus norvegicus	148-157
26054506-7	2015	Renal function, assessed as eGFR based on serum creatinine, was estimated following the MDRD-4 formula.	Creatinine	48-58	epidermal growth factor receptor	Homo sapiens	28-32
25933946-3	2015	RESULTS: Administration of CCl4 significantly (p&lt;0.001) increased the levels of renal function test such as creatinine and blood urea nitrogen (BUN).	Creatinine	111-121	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
25384728-0	2015	Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.	Creatinine	103-113	interleukin 6	Homo sapiens	32-35
25384728-7	2015	In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers.	Creatinine	114-124	interleukin 6	Homo sapiens	19-22
25707524-4	2015	Different eGFR formulas using creatinine (MDRD, CKD-EPI, Cockrauft Gault); cystatin-C (eGFR1, eGFR2) or a combination of creatinine and cystatin-C (eGFR 3) were used to calculate estimated glomerular filtration rates (eGFRs).	Creatinine	30-40	epidermal growth factor receptor	Homo sapiens	10-14
26093727-9	2015	Serum Fetuin-A levels were positively correlated with blood urea nitrogen level (r = .241, P = .025) and serum creatinine level (r = .262, P = .014), whereas it was negatively correlated with serum phosphorus level (r = -.409, P &lt; .001).	Creatinine	111-121	alpha 2-HS glycoprotein	Homo sapiens	6-14
26010898-8	2015	Urinary L-FABP levels correlated with urinary albumin-to-creatinine ratios, estimated glomerular filtration rates, body mass index, and hemoglobin levels.	Creatinine	57-67	fatty acid binding protein 1	Homo sapiens	8-14
25964218-5	2015	RESULTS: The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-beta levels in both the pretransplantation and early post-transplantation period.	Creatinine	13-23	transforming growth factor beta 1	Homo sapiens	98-106
26000752-7	2015	RESULTS: ACE I/D polymorphism was found to be associated with acute rejection (AR) in genotypes DD+ID versus II (OR = 1.62, 95% CI = 1.14-2.29) and with serum creatinine concentration after renal transplantation in genotypes DD versus ID (WMD = 13.12, 95% CI = 8.09-18.16).	Creatinine	159-169	angiotensin I converting enzyme	Homo sapiens	9-12
25945124-6	2015	RESULTS: Patients receiving a graft carrying CAV1 rs4730751 AA genotype displayed a significant decrease in estimated glomerular filtration rate and a significant increase in serum creatinine in both univariate and multivariate analyzes.	Creatinine	181-191	caveolin 1	Homo sapiens	45-49
25977378-16	2015	The only significant differences found when comparing biochemical parameters between groups were higher serum levels of both creatinine and gamma-glutamyl transferase in the experimental group with preoperative administration of MAB-TGFbeta.	Creatinine	125-135	transforming growth factor beta 1	Homo sapiens	233-240
26036542-7	2015	Metformin and insulin use seemed to significantly reduce the protein excretion and creatinine clearance decline in the studied group.	Creatinine	83-93	insulin	Homo sapiens	14-21
24626813-5	2015	Urinary L-FABP showed significant correlation with urinary albumin-to-creatinine ratio (ACR) (r = 0.51, p &lt; 0.0001).	Creatinine	70-80	fatty acid binding protein 1	Homo sapiens	8-14
25639483-1	2015	Monitoring of allograft function entails methods more accurate than serum creatinine and creatinine-based GFR equations (eGFR).	Creatinine	89-99	epidermal growth factor receptor	Homo sapiens	121-125
25710085-7	2015	Elevated serum TGF-beta1 and IL-31 levels were positively associated with albumin, alpha-fetoprotein, creatinine, white blood cell count, and platelet levels.	Creatinine	102-112	transforming growth factor beta 1	Homo sapiens	15-24
25710085-7	2015	Elevated serum TGF-beta1 and IL-31 levels were positively associated with albumin, alpha-fetoprotein, creatinine, white blood cell count, and platelet levels.	Creatinine	102-112	interleukin 31	Homo sapiens	29-34
25923243-10	2015	Serum creatinine fully normalized by twelve weeks after cessation of telaprevir in 83% of patients, however experiencing a significant creatinine rise during telaprevir use was associated with a 6.6mL/min/1.73m2 decrease in estimated glomerular filtration rate at twelve months in an adjusted model.	Creatinine	135-145	CD59 molecule (CD59 blood group)	Homo sapiens	201-206
25927214-14	2015	Patients with hAPLN were more hypertensive (OR = 3.8; 95% CI, 1.2 to 12.3; P = 0.03) and had higher levels of creatinine as compared to lupus nephritis patients (median 116 versus 75 mumol/L; P &lt; 0.0001).	Creatinine	110-120	apelin	Homo sapiens	14-19
26131190-10	2015	A positive correlation was identified between the serum creatinine (Scr) concentrations and CT, PTH, while the correlation with 25(OH)-Vit was considered to be negative.	Creatinine	56-66	parathyroid hormone	Homo sapiens	96-99
25635034-8	2015	Among normotensive children, larger GFR declines were associated with larger baseline urine protein-to-creatinine ratios; eGFR declines of 0.8 and 1.8 ml/min per 1.73 m(2) per year were associated with urine protein-to-creatinine ratio &lt;0.5 and &gt;=0.5 mg/mg, respectively.	Creatinine	219-229	epidermal growth factor receptor	Homo sapiens	122-126
25291501-12	2015	Further studies are required in Indigenous patients with creatinine clearance &lt;30 ml min(-1) .	Creatinine	57-67	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
25999961-11	2015	Patients with an elevated podocin/Cr ratio were more likely to have received &lt;=50% of the maximum dose of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (p = 0.04) than patients with a podocin/Cr ratio in the normal range.	Creatinine	34-36	NPHS2 stomatin family member, podocin	Homo sapiens	26-33
25999961-11	2015	Patients with an elevated podocin/Cr ratio were more likely to have received &lt;=50% of the maximum dose of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (p = 0.04) than patients with a podocin/Cr ratio in the normal range.	Creatinine	34-36	NPHS2 stomatin family member, podocin	Homo sapiens	215-222
25999961-11	2015	Patients with an elevated podocin/Cr ratio were more likely to have received &lt;=50% of the maximum dose of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (p = 0.04) than patients with a podocin/Cr ratio in the normal range.	Creatinine	223-225	NPHS2 stomatin family member, podocin	Homo sapiens	26-33
25999961-12	2015	CONCLUSIONS: CRS-2 may be associated with glomerular damage as evidenced by an elevated urinary podocin/Cr ratio.	Creatinine	104-106	msh homeobox 2	Homo sapiens	13-18
25388849-9	2015	p-Akt expression correlated significantly with 24-h urinary protein excretion, serum creatinine levels, tubulointerstitial mononuclear cells infiltration, smooth muscle cells (SMCs) migration in vascular wall, and IF.	Creatinine	85-95	AKT serine/threonine kinase 1	Rattus norvegicus	2-5
25894138-7	2015	Metformin and insulin use seemed to significantly reduce the protein excretion, and creatinine clearance decline in the studied group.	Creatinine	84-94	insulin	Homo sapiens	14-21
24986443-8	2015	Meanwhile, decreased serum creatinine and urea induced by PF4 were also reversed by recombinant mouse IL-17 (rmIL-17).	Creatinine	27-37	platelet factor 4	Mus musculus	58-61
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	epidermal growth factor receptor	Homo sapiens	40-44
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	epidermal growth factor receptor	Homo sapiens	40-44
25524550-7	2015	The serum concentration of creatinine was significantly (P = 0.0065) greater and eGFR was significantly (P = 0.0009) lower in individuals with the TC or CC genotype of IL6R than in those with the TT genotype.	Creatinine	27-37	interleukin 6 receptor	Homo sapiens	168-172
25888842-5	2015	Measurement by ELISA revealed that urinary Fetuin-A levels were significantly higher in 66 ADPKD patients (17.5 +- 12.5 mug/mmol creatinine) compared to 17 healthy volunteers (8.5 +- 3.8 mug/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2 +- 2.9 mug/mmol creatinine).	Creatinine	129-139	alpha 2-HS glycoprotein	Homo sapiens	43-51
25888842-5	2015	Measurement by ELISA revealed that urinary Fetuin-A levels were significantly higher in 66 ADPKD patients (17.5 +- 12.5 mug/mmol creatinine) compared to 17 healthy volunteers (8.5 +- 3.8 mug/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2 +- 2.9 mug/mmol creatinine).	Creatinine	196-206	alpha 2-HS glycoprotein	Homo sapiens	43-51
25888842-5	2015	Measurement by ELISA revealed that urinary Fetuin-A levels were significantly higher in 66 ADPKD patients (17.5 +- 12.5 mug/mmol creatinine) compared to 17 healthy volunteers (8.5 +- 3.8 mug/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2 +- 2.9 mug/mmol creatinine).	Creatinine	196-206	alpha 2-HS glycoprotein	Homo sapiens	43-51
25888842-6	2015	Receiver operating characteristics (ROC) analysis of urinary Fetuin-A levels for ADPKD rendered an optimum cut-off value of 12.2 mug/mmol creatinine, corresponding to 94% of sensitivity and 60% of specificity (area under the curve 0.74 ; p = 0.0019).	Creatinine	138-148	alpha 2-HS glycoprotein	Homo sapiens	61-69
25794135-6	2015	BRAF V600E-positive patients had no characteristic clinical phenotype except for significantly higher levels of serum creatinine (125 versus 86 mumol/l) Seven of eleven patients responded with at least very good partial response to alkylators, immunomodulatory agents or proteasome inhibitors.	Creatinine	118-128	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
25874010-9	2015	Multivariate logistic regression analysis revealed that S-1 discontinuation was significantly associated with an initial overdose of S-1, having stage I cancer, creatinine clearance &lt;66 mL/min, and a side effect of nausea.	Creatinine	161-171	proteasome 26S subunit, non-ATPase 1	Homo sapiens	56-59
25725314-3	2015	Because expression of CD55 but not CD46 and CD59 in mesothelial cells was significantly correlated to value of dialysate-to-plasma creatinine concentration ratio (D/P Cre) (p&lt;0.005) as an indicator of peritoneal function, we focused on analysis of CD55 expression of HPMCs in comparison with levels of C activation products in the PDF of the PD patients, and their background factors.	Creatinine	131-141	CD59 molecule (CD59 blood group)	Homo sapiens	44-48
25748698-5	2015	Significant decreases in serum creatinine levels were observed by -14.0% +- 14.2% in the hANP + DA group compared with the hANP + furosemide group (4.5% +- 9.6%, P = 0.0011) without increases in the renotubular and myocardial markers.	Creatinine	31-41	natriuretic peptide A	Homo sapiens	89-93
25461166-6	2015	The eFBG sensors show high specificity to CRP even in the presence of other interfering factors such as urea, creatinine and glucose.	Creatinine	110-120	C-reactive protein	Homo sapiens	42-45
25236582-11	2015	MEASUREMENTS: eGFR assessed using creatinine, cystatin C (eGFRcys), and a combination of both values (eGFRcr-cys).	Creatinine	34-44	epidermal growth factor receptor	Homo sapiens	14-18
25878372-4	2015	The study aims to compare ACE inhibitors and ARBs in terms of delaying or preventing the progression of diabetic nephropathy, association between blood pressure (B.P) and urinary albumin and also B.P and serum creatinine with ACE inhibitor and ARB, know the percentage of hyperkalemia in patients of diabetic nephropathy receiving ACE inhibitor or ARB.	Creatinine	210-220	angiotensin I converting enzyme	Homo sapiens	226-229
25878372-4	2015	The study aims to compare ACE inhibitors and ARBs in terms of delaying or preventing the progression of diabetic nephropathy, association between blood pressure (B.P) and urinary albumin and also B.P and serum creatinine with ACE inhibitor and ARB, know the percentage of hyperkalemia in patients of diabetic nephropathy receiving ACE inhibitor or ARB.	Creatinine	210-220	angiotensin I converting enzyme	Homo sapiens	226-229
25135658-9	2015	Serum IL-6 levels (pg/mL) were higher in the fatigued group (5.1 +- 3.4) than in the nonfatigued group (1.6 +- 1.5; P &lt; 0.001); serum albumin and creatinine levels were significantly lower.	Creatinine	149-159	interleukin 6	Homo sapiens	6-10
25229339-8	2015	Thus, modest early changes in serum creatinine can help target biomarker measurement for determining prognosis with urine L-FABP, providing independent and additive prognostic information when combined with clinical predictors.	Creatinine	36-46	fatty acid binding protein 1	Homo sapiens	122-128
25810785-10	2015	Significant correlations were observed between serum creatinine and Log PTH (r=0.704, p&lt;0.0001) and a negative correlation between creatinine and log vitamin D (r=-0.373, p=0.001).	Creatinine	53-63	parathyroid hormone	Homo sapiens	72-75
25700182-1	2015	BACKGROUND: Chronic kidney disease (CKD) diagnosis relies on glomerular filtration rate (eGFR) estimation, traditionally using the creatinine-based Modification of Diet in Renal Disease (MDRD) equation.	Creatinine	131-141	epidermal growth factor receptor	Homo sapiens	89-93
25689147-3	2015	We investigated whether transcript levels in mononuclear cells including IL-8 on the first postoperative day may be involved in immediate allograft dysfunction as defined by reduced relative change in plasma creatinine at the first postoperative day.	Creatinine	208-218	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
25444744-5	2015	The calculations were demonstrated by comparing eGFR values based on creatinine values determined using the enzymatic method (existing method) and Jaffe method (new method).	Creatinine	69-79	epidermal growth factor receptor	Homo sapiens	48-52
25689147-7	2015	RESULTS: Transcript levels of IL-8 and S100A8 were significantly lower in patients with relative change in plasma creatinine less than 10% at the first postoperative day.	Creatinine	114-124	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
25689147-8	2015	Receiver-operator characteristic curves showed that IL-8 predicted the relative change in plasma creatinine less than 10% (area under curve (AUC), 0.80; P = 0.0007).	Creatinine	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
25689147-9	2015	Multivariate analyses showed that lower IL-8 transcripts, longer time on dialysis, higher recipient body mass index and deceased donor type were associated with relative change in plasma creatinine at the first postoperative day less than 10%.	Creatinine	187-197	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
25461394-6	2015	Multivariate analysis revealed that gestational age at blood sampling, triglycerides (TG), and creatinine independently and positively predicted Pref-1 levels (p&lt;0.05).	Creatinine	95-105	delta like non-canonical Notch ligand 1	Homo sapiens	145-151
25461406-13	2015	Multivariable analysis showed that lower clearance of TNF-alpha remained independently associated with high mortality after adjustment for sex, age, use of vasoactive drugs, APACHE II score sepsis, creatinine and lactate before CVVHDF (HR: 0.179, 95% IC: 0.049-0.661, p&lt;0.01).	Creatinine	198-208	tumor necrosis factor	Homo sapiens	54-63
25624376-7	2015	Urine interleukin-1beta level was significantly lower in colostrum group at 2 weeks (55.3 vs 91.8 mug/g creatinine, P = .01).	Creatinine	104-114	interleukin 1 beta	Homo sapiens	6-23
25688259-6	2015	We found a significant (p &lt; 1.58 x 10(-7)) association for a SNP in a novel gene for serum creatinine (PTPLAD2).	Creatinine	94-104	3-hydroxyacyl-CoA dehydratase 4	Homo sapiens	106-113
25592634-8	2015	Also, CRP levels strongly correlated with the value of PaO2/FiO2 ratio (r = -0.69, p &lt; 0.001) and creatinine (r = 0.60, p &lt; 0.001).	Creatinine	101-111	C-reactive protein	Homo sapiens	6-9
26381887-2	2015	Among persons with preserved kidney function by creatinine-based eGFR (eGFRcreat&gt;60 ml/min/1.73 m2), tools to guide cystatin C testing are needed.	Creatinine	48-58	epidermal growth factor receptor	Homo sapiens	65-69
25192677-12	2015	Patients with FioPTH &lt;40 were younger, with lower preoperative serum calcium, PTH, and creatinine (all p &lt;= 0.001).	Creatinine	90-100	parathyroid hormone	Homo sapiens	17-20
25612475-7	2015	RESULTS: Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), the L-arginine/ADMA ratio and insulin resistance were associated with creatinine-based eGFR after accounting for measured GFR in multivariable adjusted analyses.	Creatinine	150-160	insulin	Homo sapiens	110-117
25792473-10	2015	Mean urine VEGF values were minimum in the control group (22.75 +- 15.41 pg/mg creatinine) and maximum in stage IV patients (180.15 +- 75.93 pg/mg creatinine).	Creatinine	79-89	vascular endothelial growth factor A	Homo sapiens	11-15
25792473-10	2015	Mean urine VEGF values were minimum in the control group (22.75 +- 15.41 pg/mg creatinine) and maximum in stage IV patients (180.15 +- 75.93 pg/mg creatinine).	Creatinine	147-157	vascular endothelial growth factor A	Homo sapiens	11-15
25341894-5	2015	In multiple regression, age, creatinine, and clinical signs of increased cerebral ischaemia were independent predictors of FPR2/ALX expression.	Creatinine	29-39	formyl peptide receptor 3	Mus musculus	128-131
26299069-8	2015	Higher urine PRL levels were associated with lower glomerular filtration rates, higher serum creatinine, and higher urinary albumin-to-creatinine ratios (UACR).	Creatinine	93-103	prolactin	Homo sapiens	13-16
26299069-8	2015	Higher urine PRL levels were associated with lower glomerular filtration rates, higher serum creatinine, and higher urinary albumin-to-creatinine ratios (UACR).	Creatinine	135-145	prolactin	Homo sapiens	13-16
25792383-1	2015	BACKGROUND: The urinary C-peptide/creatinine ratio (UCPCR) and fasting C-peptide level can assess beta-cell function in clinical practice.	Creatinine	34-44	insulin	Homo sapiens	24-33
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p &lt; 0.001).	Creatinine	176-186	C-reactive protein	Homo sapiens	90-93
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p &lt; 0.001).	Creatinine	176-186	interleukin 6	Homo sapiens	95-108
26106251-7	2015	Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-alpha, while correlating negatively and significantly with eGFR.	Creatinine	256-266	granulin precursor	Homo sapiens	6-10
26106251-7	2015	Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-alpha, while correlating negatively and significantly with eGFR.	Creatinine	268-271	granulin precursor	Homo sapiens	6-10
25593826-11	2015	The albumin concentration (r = -0.114) accounted for 0.3% (P &lt; 0.05) of the total variance in HbA1c independent of age, body mass index, FPG, Hb, creatinine, total protein and globulin.	Creatinine	149-159	albumin	Homo sapiens	4-11
25039814-11	2015	As telaprevir has been shown to inhibit mostly the drug transporter OCT2 which interacts with creatinine transport, the early decrease of eGFR observed could be a benign phenomenon.	Creatinine	94-104	epidermal growth factor receptor	Homo sapiens	138-142
26226964-7	2015	In elderly men, plasma TNF-alpha level was positively associated with age, white blood cell count, monocyte count, plasma CRP level, serum creatinine, ureic acid, and triacylglycerol levels, and negatively associated with albumin/globulin ratio, eGFR, and serum HDL-cholesterol level.	Creatinine	139-149	tumor necrosis factor	Homo sapiens	23-32
25792135-7	2015	The graft rs2630578 BICD1 gene polymorphism CC genotype was associated with lower creatinine concentrations in the first month (CC vs. GC: 1.11+-0.06 vs. 2.0+-1.25 mg/dL, p=0.03).	Creatinine	82-92	BICD cargo adaptor 1	Homo sapiens	20-25
25572193-5	2015	RESULTS: Median concentrations of urine AQP1 and PLIN2 in patients with clear cell and papillary RCC (n=47) were 29 and 36 relative absorbance units/mg urine creatinine, respectively.	Creatinine	158-168	aquaporin 1 (Colton blood group)	Homo sapiens	40-44
25572193-5	2015	RESULTS: Median concentrations of urine AQP1 and PLIN2 in patients with clear cell and papillary RCC (n=47) were 29 and 36 relative absorbance units/mg urine creatinine, respectively.	Creatinine	158-168	perilipin 2	Homo sapiens	49-54
26663989-6	2015	Additionally, Gal-9 was found to be independently associated with hs-CRP, lipoprotein(a), and creatinine.	Creatinine	94-104	galectin 9	Homo sapiens	14-19
25142083-0	2015	The ratios of urinary beta2-microglobulin and NAG to creatinine vary with age in children.	Creatinine	53-63	N-acetyl-alpha-glucosaminidase	Homo sapiens	46-49
26727745-11	2015	The correlations between serum creatinine and eGFR, gender and age were studied.	Creatinine	31-41	epidermal growth factor receptor	Homo sapiens	46-50
26517083-11	2015	RESULTS: Using CKD-EPI creatinine-cystatin C formula the eGFR in patients was 7-130 ml/min/1.73 m2 (mean 32.6; SD+-24.6).	Creatinine	23-33	epidermal growth factor receptor	Homo sapiens	57-61
25826492-8	2015	Percentage of TLR4-positive tubes correlated inversely to markers of kidney damage: to proteinuria (r=-0.55, p=0.02), serum creatinine (r=-0.53, p=0.01); percentage of glomeruli with glomerulosclerosis (r=-0.54, p=0.01) and tubulointerstitial score (r=-0.36, p=0.01).	Creatinine	124-134	toll-like receptor 4	Rattus norvegicus	14-18
25521113-7	2014	Elevation of urinary LTE4 levels (&gt;=500 pg/mg of creatinine) significantly discriminated high serum total IgE levels (&gt;=100 kU/L) at age 2 (P = 0.027).	Creatinine	52-62	immunoglobulin heavy constant epsilon	Homo sapiens	109-112
25271041-4	2014	RESULTS: Mortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.	Creatinine	58-68	fatty acid binding protein 1	Homo sapiens	107-113
25297990-10	2014	CONCLUSIONS: A CCr &lt; 60 ml/min was a significant risk factor for the 6-month discontinuation of S-1 adjuvant chemotherapy in pancreatic cancer patients, even though the renal function was judged to be normal based on the serum creatinine level.	Creatinine	230-240	proteasome 26S subunit, non-ATPase 1	Homo sapiens	99-102
24939145-7	2014	MMF administration decreased the gene expression of TNF-alpha and TGF-beta1 in kidney tissues, serum glucose, fructosamine, urea, creatinine, C-reactive protein, malondialdehyde, urinary microalbumin and total protein.	Creatinine	130-140	tumor necrosis factor	Rattus norvegicus	52-61
25039474-8	2014	Urinary nerve growth factor/creatinine was significantly decreased after dutasteride from 2.61 +- 2.50 to 1.64 +- 1.68.	Creatinine	28-38	nerve growth factor	Homo sapiens	8-27
25039474-9	2014	The change of urinary nerve growth factor/creatinine significantly correlated only with the change of prostatic volume (r = 0.38) and bladder outlet obstruction index (r = 0.36).	Creatinine	42-52	nerve growth factor	Homo sapiens	22-41
25070937-10	2014	The pro-renin level correlated positively with serum creatinine at presentation (correlation coefficient 0.671, P-value&lt;0.001), blood urea at initial presentation (correlation coefficient 0.684, P-value&lt;0.001), serum creatinine at follow-up (correlation coefficient 0.546, P-value&lt;0.001) and blood urea at follow-up (correlation 0.603, P-value&lt;0.001).	Creatinine	53-63	renin	Homo sapiens	8-13
25070937-10	2014	The pro-renin level correlated positively with serum creatinine at presentation (correlation coefficient 0.671, P-value&lt;0.001), blood urea at initial presentation (correlation coefficient 0.684, P-value&lt;0.001), serum creatinine at follow-up (correlation coefficient 0.546, P-value&lt;0.001) and blood urea at follow-up (correlation 0.603, P-value&lt;0.001).	Creatinine	223-233	renin	Homo sapiens	8-13
24423482-9	2014	The urinary ET-1 concentrations in patients with CIN decreased significantly more than in patients without CIN (-0.26+-1.42 pg/ml vs. -0.79+-1.69 pg/ml, p=0.041), whereas the decrease of the urinary ET-1/creatinine ratio was not significantly different (non-CIN patients: -0.05+-0.30; CIN patients: -0.11+-0.21, p=0.223).	Creatinine	204-214	endothelin 1	Homo sapiens	12-16
25052363-11	2014	A positive correlation was found between urinary HMGB1/creatinine ratio and CD4(+) T cells/creatinine ratio (P = 0 028) and effector memory T cells/creatinine ratio (P = 0 039) in urine.	Creatinine	55-65	CD4 molecule	Homo sapiens	76-79
25406080-8	2014	In total, 36.5% of patients had self-referred to the nephrologist; patients with diabetes or serum creatinine above 220 micromol/l (eGFR&lt;40 ml/min/1.73 m2) were more likely to have been referred by a physician.	Creatinine	99-109	epidermal growth factor receptor	Homo sapiens	132-136
28509189-2	2014	His creatinine clearance levels had fallen to 76.3 mL/min/1.73 m2.	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
25071077-3	2014	We hypothesized that measured insulin sensitivity (glucose infusion rate [GIR]) would be associated with early markers of DN reflected by estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR) in adolescents with type 2 diabetes.	Creatinine	194-204	insulin	Homo sapiens	30-37
25312351-8	2014	RESULTS: In this trial, levetiracetam total clearance decreased proportionally with creatinine clearance: 52, 31, 25, 20 and 11 mL/min/1.73 m(2) in healthy controls and in patients with mild, moderate, severe renal impairment, and ESRD, respectively.	Creatinine	84-94	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
24929205-7	2014	Both natural logarithm of urinary AGT/creatinine (ln [urinary AGT/Cr]) and ln (urinary renin/Cr) showed positive correlations with urinary P/Cr.	Creatinine	38-48	angiotensinogen	Homo sapiens	34-37
25168126-5	2014	Baseline serum hs-CRP levels were significantly associated with the urinary albumin-to-creatinine ratio at baseline (P &lt; 0.001).	Creatinine	87-97	C-reactive protein	Homo sapiens	18-21
24866276-8	2014	Urinary NGF and creatinine-normalized NGF levels were significantly increased in those with OAB (201.90 and 4.08, respectively) and BPS/IC (173.71 and 2.72) compared with controls (77.77 and 1.29) and those with frequency (67.76 and 1.23).	Creatinine	16-26	nerve growth factor	Homo sapiens	38-41
25484928-6	2014	Pearson correlation analyses adjusted for the covariates age, sex, apolipoprotein E (ApoE), education and creatinine levels showed neuroimaging ROIs were associated with Abeta levels.	Creatinine	106-116	amyloid beta precursor protein	Homo sapiens	170-175
25484928-9	2014	RESULTS: The left hippocampus was the brain region most correlated with Abeta(1-40) bound to blood cell pellets (partial correlation (pcor) = -0.37, P = 0.0007) after adjustment for the covariates age, gender and education, ApoE and creatinine levels.	Creatinine	233-243	amyloid beta precursor protein	Homo sapiens	72-77
24702136-9	2014	A logistic regression model revealed that the odds of having aortic stiffness were increased by 56% with a 1-SD increase of log albumin:creatinine ratio after adjustment for age, gender, duration of diabetes, HbA1c , blood pressure, HDL and LDL cholesterol, estimated glomerular filtration rate, BMI, usage of renin-angiotensin system antagonists, statins and insulin.	Creatinine	136-146	renin	Homo sapiens	310-315
24854162-9	2014	Furthermore, we found that the decreased serum creatinine level and the reduced expression of collagen and smooth muscle actin induced by PTX3 were abolished by additional administration of IL-6.	Creatinine	47-57	pentraxin related gene	Mus musculus	138-142
24854162-9	2014	Furthermore, we found that the decreased serum creatinine level and the reduced expression of collagen and smooth muscle actin induced by PTX3 were abolished by additional administration of IL-6.	Creatinine	47-57	interleukin 6	Mus musculus	190-194
25371529-11	2014	We did observe a direct relationship between TNF-alpha and creatinine.	Creatinine	59-69	tumor necrosis factor	Homo sapiens	45-54
25356114-7	2014	IL-6 significantly reduced LVDP and average +-dP/dt, increased the activities of ALT and AST, and increased the concentration of creatinine in the sepsis rats.	Creatinine	129-139	interleukin 6	Rattus norvegicus	0-4
25151892-3	2014	Significant correlations in eGFR and urinary 20-HETE/creatinine and 19-HETE/creatinine levels were observed.	Creatinine	53-63	epidermal growth factor receptor	Homo sapiens	28-32
25151892-3	2014	Significant correlations in eGFR and urinary 20-HETE/creatinine and 19-HETE/creatinine levels were observed.	Creatinine	76-86	epidermal growth factor receptor	Homo sapiens	28-32
25215505-4	2014	After verification by western blotting, the urinary levels of ORM1 were quantified with enzyme-linked immunosorbent assay (ELISA) by correcting for creatinine expression.	Creatinine	148-158	orosomucoid 1	Homo sapiens	62-66
24984169-6	2014	Creatinine was lower in subjects with lower revised ALS Functional Rating Scale (ALSFRS-R) scores.	Creatinine	0-10	superoxide dismutase 1	Homo sapiens	52-55
25105834-6	2014	Ang II increased plasma creatinine, urinary NAG activity, and histological changes, and enhanced RSNA compared with the IR group (p &lt; 0.05).	Creatinine	24-34	angiotensinogen	Rattus norvegicus	0-6
25485543-8	2014	Plasma levels of IL-6 were positively related to sCD14 and serum creatinine.	Creatinine	65-75	interleukin 6	Homo sapiens	17-21
24126695-10	2014	Multiple regression analysis showed that gender (p = 0.022), presence of diabetes (p &lt; 0.001), albumin (p = 0.010), and serum creatinine (p = 0.037) were independent factors for circulating sclerostin level.	Creatinine	129-139	sclerostin	Homo sapiens	193-203
25048026-10	2014	Multivariable analysis showed that serum albumin (men: hazard ratio [HR], 1.39; 95% CI, 1.05-1.90; P = .02; women: HR, 1.73; 95 % CI, 1.35-2.39; P = .001) and creatinine (men: HR, 1.47; 95% CI, 1.11-1.95; P = .007; women: HR, 1.49; 95% CI, 1.07-2.05; P = .02) were independent predictors of survival in both sexes; no other hematological factor was retained in the model.	Creatinine	159-169	albumin	Homo sapiens	41-48
24059745-10	2014	Multivariate regression analysis showed that hs-cTnT was independently associated with LV geometry (beta = 0.326, p = 0.001) as well as LVMI (beta = 0.228, p = 0.010) and creatinine level beta = 0.132, p = 0.012).	Creatinine	171-181	troponin T2, cardiac type	Homo sapiens	48-52
25337473-9	2014	There was a significant association between the history of high blood pressure, C-reactive protein and preoperative creatinine levels in both cognitive disorder and control groups.	Creatinine	116-126	C-reactive protein	Homo sapiens	80-98
25349694-8	2014	A rise of serum creatinine was noted during fasting in 60.4% of patients by Day 7 and was associated with intake of renin angiotensin aldosterone system antagonists [relative risk (RR) 2, P = 0.002].	Creatinine	16-26	renin	Homo sapiens	116-121
25852909-6	2014	RESULTS: Urinary angiotensinogen was higher in microalbuminuric and macroalbuminuric diabetes than in controls [63.44 (interquartile range, IQR: 22.08, 174.8) versus 398.38 (IQR: 205.03, 673.68) versus 9.12 (IQR: 3.76, 23.82) ng/mg creatinine, respectively, P &lt; 0.001].	Creatinine	232-242	angiotensinogen	Homo sapiens	17-32
25852909-7	2014	In diabetes with normoalbuminuria, urinary angiotensinogen was also higher than in controls [16.42 (IQR: 7.69, 34.71) versus 9.12 (IQR: 3.76, 23.82) ng/mg creatinine, P = 0.047].	Creatinine	155-165	angiotensinogen	Homo sapiens	43-58
25852909-9	2014	The areas under the curve for the diagnosis of established normoalbuminuric, microalbuminuric and macroalbuminuric type 2 diabetes using urine angiotensinogen (ng/mg creatinine) were 0.62 (95% CI: 0.48-0.77), 0.85 (95% CI: 0.76-0.94) and 0.96 (95% CI: 0.92-1.00), respectively.	Creatinine	166-176	angiotensinogen	Homo sapiens	143-158
24085462-4	2014	External and internal CS2 exposure of the employees decreased from 1992 (medians 4.0 ppm and 1.63 mgTTCA/g creatinine) to 2009 (medians 2.5 ppm and 0.86 mg/g).	Creatinine	107-117	chorionic somatomammotropin hormone 2	Homo sapiens	22-25
24315756-7	2014	MEASUREMENTS AND MAIN RESULTS: The mean preoperative eGFR (s-creatinine) was 67+-24 mL/min/1.73 m2 compared to 45+-21 mL/min/1.73 m2 with eGFR (cystatin C) (p&lt;0.001).	Creatinine	61-71	epidermal growth factor receptor	Homo sapiens	53-57
24846444-5	2014	RESULTS: Compared with the controls, urinary [angiotensinogen:creatinine] were significantly higher in T2DM patients without nephropathy (4.70 +- 2.22 vs. 8.31 +- 5.27 mug/g, p=0.037).	Creatinine	62-72	angiotensinogen	Homo sapiens	46-61
24251918-9	2014	There was significant benefit on creatinine clearance in patients with impaired renal function at 6 months [+12.23 (+5.26, +18.82) ml min(-1) , P = 0.0003] and at 12 months 4.63 [-4.55, 13.82] P = 0.32 I(2)  = 75%.	Creatinine	33-43	CD59 molecule (CD59 blood group)	Homo sapiens	134-140
24903387-4	2014	Kidney function was measured by serum creatinine-based eGFR at a core laboratory.	Creatinine	38-48	epidermal growth factor receptor	Homo sapiens	55-59
24846444-6	2014	Age, hemoglobin A1c (HbA1c) and fasting plasma glucose correlated significantly and positively with the log{urinary [angiotensinogen:creatinine]} (r=0.632, p=0.007; r=0.405, p=0.027; r=0.583, p=0.003, respectively) in T2DM patients without nephropathy.	Creatinine	133-143	angiotensinogen	Homo sapiens	117-132
24777983-4	2014	Urinary angiotensinogen to creatinine ratio (angiotensinogen/creat) was correlated with plasma angiotensinogen concentrations (P&lt;0.0005) but not with indexes of salt intake.	Creatinine	27-37	angiotensinogen	Homo sapiens	45-60
24846719-9	2014	In multivariate logistic regression models, PGE-MUM was a significant independent predictor of histologic remission (sensitivity/specificity, 0.82/0.82) when the cutoff value was set to 17.0 mug/g creatinine, but CRP was not (0.69/0.69) (P &lt; 0.01).	Creatinine	197-207	latexin	Homo sapiens	48-51
24777983-4	2014	Urinary angiotensinogen to creatinine ratio (angiotensinogen/creat) was correlated with plasma angiotensinogen concentrations (P&lt;0.0005) but not with indexes of salt intake.	Creatinine	27-37	angiotensinogen	Homo sapiens	45-60
25317609-7	2014	Positive association was observed between the levels of NGAL, creatinine and C-reactive protein.	Creatinine	62-72	C-reactive protein	Homo sapiens	77-95
24596064-1	2014	BACKGROUND: Different serum creatinine (sCr) assays may obtain different values in the same patient, causing discrepancies in estimated glomerular filtration rate (eGFR) and sCr-based vancomycin dosing calculations.	Creatinine	28-38	epidermal growth factor receptor	Homo sapiens	164-168
24887412-8	2014	Treatments with either TNF-alpha antibodies or 2-APB also significantly improved the compromised GFR, elevated serum urea nitrogen and creatinine levels, and reversed the decrease in glomerular inulin space and the increase in glomerular calcium content in GalN/LPS-exposed rats.	Creatinine	135-145	tumor necrosis factor	Rattus norvegicus	23-32
25170411-1	2014	OBJECTIVES: To assess urinary NAG/ urinary creatinine (NAG/ Cr) ratio in patients with urological abnormalities (normal and abnormal ultrasonography) and compare it with normal healthy children.	Creatinine	43-53	N-acetyl-alpha-glucosaminidase	Homo sapiens	55-58
25178592-2	2014	The aim of the study was to explore the status of serum albumin &amp; creatinine clearance levels in smear positive Bangladeshi pulmonary tuberculosis patients as a means to monitor the possibility of management of these patients as these levels decrease significantly.	Creatinine	70-80	albumin	Homo sapiens	50-63
25178592-12	2014	It is evident from the study that serum albumin &amp; creatinine clearance rate levels significantly decrease in smear positive Bangladeshi pulmonary tuberculosis patients.	Creatinine	54-64	albumin	Homo sapiens	34-47
25170411-8	2014	The current results revealed that NAG/creatinine index was significantly higher in all patients with (vesicoureteral reflux, hydronephrosis and pyelonephritis) in comparison with cystitis.	Creatinine	38-48	N-acetyl-alpha-glucosaminidase	Homo sapiens	34-37
24867503-7	2014	Given at the above doses conferred significant protection against the hepatotoxic actions of CCl4 in rats, reducing serum markers like SGOT, SGPT, ALP, creatinine and urea levels back to near normal (p&lt;0.05) compared to untreated rats.	Creatinine	152-162	C-C motif chemokine ligand 4	Rattus norvegicus	93-97
24794250-14	2014	In a general linear model, adjusting for bladder volume and urinary creatinine, increasing Log10 NGF was associated with higher Gleason score (Gleason category &lt;=6, 7, and &gt;=8; P = 0.003).	Creatinine	68-78	nerve growth factor	Homo sapiens	97-100
25177848-16	2014	Average 24 hours creatinine clearance was 98.64 +- 22 mL/min/1.73 m2, with chronic renal failure data in 6 patients.	Creatinine	17-27	CD59 molecule (CD59 blood group)	Homo sapiens	57-62
24326128-4	2014	Adjusted odds ratios for an elevated urinary NAG index (&gt;5.8U/g creatinine) according to the HbA1c (&lt;=5.4%, 5.5%-5.9%, and 6.0%-6.4%) and 1,5-AG tertiles were calculated.	Creatinine	67-77	N-acetyl-alpha-glucosaminidase	Homo sapiens	45-48
24623023-0	2014	Home urine C-peptide creatinine ratio can be used to monitor islet transplant function.	Creatinine	21-31	insulin	Homo sapiens	11-20
24511990-4	2014	Results showed that pre-treatment with SMAD7 prevented AngII-induced progressive renal injury by inhibiting an increase in proteinuria and serum creatinine while improving the glomerular filtration rate.	Creatinine	145-155	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	55-60
24612017-9	2014	Furthermore, relative changes of FGF-21 were independently and positively predicted by relative changes of creatinine.	Creatinine	107-117	fibroblast growth factor 21	Homo sapiens	33-39
24623023-2	2014	We assessed whether urine C-peptide creatinine ratio (UCPCR) sent from home could provide a viable alternative.	Creatinine	36-46	insulin	Homo sapiens	26-35
24819446-6	2014	In particular, the inhibition of creatinine secretion by the proximal renal tubule will require the acquisition of competences in estimating the real glomerular filtration rate, since studies with iohexol clearance have shown that the eGFR reduction is cosmetic.	Creatinine	33-43	epidermal growth factor receptor	Homo sapiens	235-239
24727856-12	2014	The ERK inhibitor U0126 resulted in lower BUN and serum creatinine, suggesting a mechanistic role of ERK in AKI.	Creatinine	56-66	mitogen-activated protein kinase 1	Mus musculus	4-7
24793984-6	2014	Median (IQR) urine AGT concentrations were 226.0 (82.1, 550.3) and 13.0 (7.8, 20.0) mug/g creatinine in type 1 diabetes with and without DKD, respectively (P &lt; 0.001).	Creatinine	90-100	angiotensinogen	Homo sapiens	19-22
26625365-6	2014	Acute kidney injury was defined using adapted pediatric RIFLE criteria as an increase in serum creatinine from baseline of 50% or more.	Creatinine	95-105	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	56-61
24319012-5	2014	RESULTS: Serum creatinine in the anti-moesin autoantibody-positive group was higher than that in the negative group.	Creatinine	15-25	moesin	Homo sapiens	38-44
24362637-2	2014	Of 332 patients who received an ACE inhibitor as inpatients at our institution from 1 January 2010 to 1 July 2012, 20 patients had a doubling of serum creatinine (SCr) within 72 h after initiation or dose uptitration of an ACE inhibitor (AKI group).	Creatinine	151-161	angiotensin I converting enzyme	Homo sapiens	32-35
24206243-3	2014	Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and urea levels (P&lt;0.01) in patients with AKI, which then fell after recovery from AKI.	Creatinine	91-101	C-reactive protein	Homo sapiens	27-30
24569419-8	2014	In contrast, a gene-family analysis considering the joint impact of all 61 SNPs reveals significant associations of the nAChR gene family with kidney function variables including estimated glomerular filtration rate, urinary albumin/creatinine ratio, and albuminuria (all Ps &lt;= 0.0001) after adjusting for established risk factors including cigarette smoking.	Creatinine	233-243	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	120-125
24759300-6	2014	We used residual analyses and graphical methods to model the functional relationship of spot urine phosphate and creatinine measurements with 24hUrP.	Creatinine	113-123	urotensin 2B	Homo sapiens	144-148
24759300-12	2014	CONCLUSION: We describe a novel equation to predict 24hUrP excretion using spot urine phosphate and creatinine, age, sex, and weight.	Creatinine	100-110	urotensin 2B	Homo sapiens	54-58
24482023-9	2014	IFN-gamma immunostaining correlated positively with serum creatinine and negatively with albumin levels and glomerular filtration rate (GFR).	Creatinine	58-68	interferon gamma	Homo sapiens	0-9
24164392-9	2014	All four patients with L-FABP&gt;17.5 mug/g creatinine were HIV/HCV coinfected.	Creatinine	44-54	fatty acid binding protein 1	Homo sapiens	23-29
24164392-10	2014	On multivariate logistic regression urine L-FABP above 5.5 mug/g creatinine was independently associated with body weight (OR=0.93 p=0.039).	Creatinine	65-75	fatty acid binding protein 1	Homo sapiens	42-48
24570078-4	2014	RESULTS: Serum creatinine levels on postoperative days (POD) 1 and 3 were significantly lower than baseline values in the nicardipine group (n = 50).	Creatinine	15-25	coronin 7	Homo sapiens	36-68
23877710-0	2014	Lower serum albumin level is associated with higher fractional excretion of creatinine.	Creatinine	76-86	albumin	Homo sapiens	12-19
23877710-3	2014	Association of serum albumin level with the tubular secretion of creatinine was also reported previously.	Creatinine	65-75	albumin	Homo sapiens	21-28
23877710-21	2014	Alteration of FE-Cr according to the serum albumin levels may be one of the reasons of the bias of GFR equation based on serum creatinine.	Creatinine	127-137	albumin	Homo sapiens	43-50
24750830-11	2014	The area of claudin-2 expression was negatively correlated with serum creatinine level and tubulointerstitial damage score (r=-0.809 and -0.903; P&lt;0.01).	Creatinine	70-80	claudin 2	Homo sapiens	12-21
24515114-11	2014	Blood urea nitrogen and creatinine values tended to be lower after inhibiting RAGE.	Creatinine	24-34	advanced glycosylation end product-specific receptor	Mus musculus	78-82
24658608-12	2014	When we analyzed the MYH9 E1 haplotype, the GCCT carriers (1 or 2 alelles present in 29.7% in the PO group vs. 18.5% in controls) showed a significant association to the risk of PO, even after adjustments for baseline estimated creatinine clearance and autossomal ancestry (HR 2.0, 95%CI 1.2-3.4, p = 0.01).	Creatinine	228-238	myosin heavy chain 9	Homo sapiens	21-25
24452639-12	2014	There was a positive linear correlation between urinary ACE2 and albuminuria, blood glucose, plasma creatinine, glucagon, and triglycerides.	Creatinine	100-110	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	56-60
24667560-8	2014	RESULTS: TRAIL(-/-)ApoE(-/-) mice had significantly increased urine protein, urine protein:creatinine ratio, plasma phosphorous, and plasma cystatin C, with accelerated nephropathy.	Creatinine	91-101	apolipoprotein E	Mus musculus	19-23
24476501-7	2014	The mean serum creatinine at follow-up was 111 muM (+-38.62).	Creatinine	15-25	latexin	Homo sapiens	47-50
24438875-1	2014	BACKGROUND AND OBJECTIVES: Insulin resistance has been shown to be closely associated with glomerular filtration rate and urinary albumin/creatinine ratio, even prior to the development of diabetes.	Creatinine	138-148	insulin	Homo sapiens	27-34
24438875-6	2014	RESULTS: Lower insulin sensitivity was associated with higher urinary KIM-1 in both cohorts after adjustments for age, BMI, blood pressure, antihypertensive treatment, glomerular filtration rate, and urinary albumin-creatinine ratio (PIVUS: regression coefficient for 1-SD higher HOMA-IR 0.11, 95% CI 0.03-0.20, p=0.009, and ULSAM: 0.13, 95% CI 0.04-0.22, p=0.007).	Creatinine	216-226	insulin	Homo sapiens	15-22
24582841-8	2014	In patients who subsequently developed acute kidney injury, significant increases in L-FABP were noted from 2.9 (3.6) ng/mg of creatinine before CPB to 62.1 (995.6) ng/mg of creatinine 5 minutes after termination of circulatory arrest.	Creatinine	127-137	fatty acid binding protein 1	Homo sapiens	85-91
24342929-6	2014	In linear regression analyses comprising age, smoking, triglyceride, HDL-cholesterol, C-reactive protein and waist circumference as well, creatinine was significantly and independently associated with ADMA, further in women glucose (inversely).	Creatinine	138-148	C-reactive protein	Homo sapiens	86-104
23564381-11	2014	AM concentrations in effluent did not correlate with plasma AM level but correlated well with the dialysate-to-plasma ratio of creatinine (D/P ratio of creatinine).	Creatinine	127-137	activating transcription factor 7 interacting protein	Mus musculus	0-2
23564381-11	2014	AM concentrations in effluent did not correlate with plasma AM level but correlated well with the dialysate-to-plasma ratio of creatinine (D/P ratio of creatinine).	Creatinine	152-162	activating transcription factor 7 interacting protein	Mus musculus	0-2
24009290-8	2014	Apo B was lower among older patients, patients with higher serum creatinine and patients with lower BMI.	Creatinine	65-75	apolipoprotein B	Homo sapiens	0-5
24800491-10	2014	However, the relationship between eGFR and the hazard risk of events is different depending on whether cystatin C or creatinine is used to calculate eGFR.	Creatinine	117-127	epidermal growth factor receptor	Homo sapiens	34-38
24800492-7	2014	With respect to acute kidney disease (AKI), urinary L-FABP facilitates the early detection of AKI before an increase in serum creatinine.	Creatinine	126-136	fatty acid binding protein 1	Homo sapiens	52-58
24489966-8	2014	Furthermore, serum CXCL16 concentration negatively correlated with estimated glomerular filtrate rate, creatinine clearance rate and blood albumin, and positively with 24 h proteinuria, blood urea nitrogen (BUN), creatinine, and uric acid after adjusting for age, gender and BMI in subjects with DN.	Creatinine	103-113	C-X-C motif chemokine ligand 16	Homo sapiens	19-25
24489966-8	2014	Furthermore, serum CXCL16 concentration negatively correlated with estimated glomerular filtrate rate, creatinine clearance rate and blood albumin, and positively with 24 h proteinuria, blood urea nitrogen (BUN), creatinine, and uric acid after adjusting for age, gender and BMI in subjects with DN.	Creatinine	213-223	C-X-C motif chemokine ligand 16	Homo sapiens	19-25
24503548-12	2014	The urine nestin-to-creatinine ratio increased earlier than serum creatinine in AKI patients with postcardiovascular surgeries.	Creatinine	20-30	nestin	Homo sapiens	10-16
24981694-13	2014	Higher levels of apolipoprotein B and total cholesterol were independent predictors of increased albumin-creatinine ratio.	Creatinine	105-115	apolipoprotein B	Homo sapiens	17-33
24201575-7	2014	RESULTS: Even in the absence of diabetes, Lxralpha/beta (-/-) mice exhibited a tenfold increase in the albumin:creatinine ratio and a 40-fold increase in glomerular lipid accumulation compared with Lxralpha/beta (+/+) mice.	Creatinine	111-121	nuclear receptor subfamily 1, group H, member 3	Mus musculus	42-50
24090674-5	2014	The starting dose of S-1 was determined on the basis of body surface area and modified according to the creatinine clearance value.	Creatinine	104-114	proteasome 26S subunit, non-ATPase 1	Homo sapiens	21-24
24184549-10	2014	Also in males, BPA concentration unadjusted for creatinine was significantly associated with serum fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR) showing non-monotonic exposure-response relationship.	Creatinine	48-58	insulin	Homo sapiens	107-114
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	C-C motif chemokine ligand 28	Homo sapiens	24-27
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	C-C motif chemokine ligand 28	Homo sapiens	109-112
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	C-C motif chemokine ligand 28	Homo sapiens	109-112
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	C-C motif chemokine ligand 28	Homo sapiens	109-112
24220551-4	2014	This study aimed at assessing the impact of analytical characteristics (bias and imprecision) of 12 enzymatic and 4 compensated Jaffe previously characterized creatinine assays on MDRD and CKD-EPI eGFR.	Creatinine	159-169	epidermal growth factor receptor	Homo sapiens	197-201
24220551-10	2014	Compensated Jaffe creatinine assays lead to important errors in eGFR and should be avoided.	Creatinine	18-28	epidermal growth factor receptor	Homo sapiens	64-68
24582841-8	2014	In patients who subsequently developed acute kidney injury, significant increases in L-FABP were noted from 2.9 (3.6) ng/mg of creatinine before CPB to 62.1 (995.6) ng/mg of creatinine 5 minutes after termination of circulatory arrest.	Creatinine	174-184	fatty acid binding protein 1	Homo sapiens	85-91
25232564-0	2014	Rates and predictors of ACE inhibitor discontinuation subsequent to elevated serum creatinine: a retrospective cohort study.	Creatinine	83-93	angiotensin I converting enzyme	Homo sapiens	24-27
25246279-4	2014	We found a positive correlation between AGEs and MCP-1 and between TNF-alpha and creatinine in PGC group.	Creatinine	81-91	tumor necrosis factor	Homo sapiens	67-76
25246279-4	2014	We found a positive correlation between AGEs and MCP-1 and between TNF-alpha and creatinine in PGC group.	Creatinine	81-91	progastricsin	Homo sapiens	95-98
24381864-17	2014	We found that erythropoietin was able to prevent the increase in serum creatinine and blood urea nitrogen.	Creatinine	71-81	erythropoietin	Homo sapiens	14-28
25232564-1	2014	OBJECTIVES: ACE inhibitors (ACEI) are underutilised despite cardiovascular benefits, in part due to concerns of known transient elevations in serum creatinine (SCr) after initiation.	Creatinine	148-158	angiotensin I converting enzyme	Homo sapiens	12-15
24452940-9	2014	When the data on age, uric acid, BMI, glucose, creatinine, and hemoglobin were split into 3 as low-1/3, mid-1/3 and  high 1/3, there was significant graded decrease in EDD and EID with these parameters.	Creatinine	47-57	midline 1	Homo sapiens	104-125
25053944-9	2014	There was a strong correlation between sclerostin level with renal function presented as serum creatinine (r = 0.745, P &lt; 0.001) and eGFR (r = -0.590, P &lt; 0.001).	Creatinine	95-105	sclerostin	Homo sapiens	39-49
23229315-6	2014	The increase of plasma creatinine levels negatively correlated with renal antioxidant defenses including ascorbic acid (AA) and reduced glutathione (GSH) content as well as glutathione S-transferase (GST), glutathione peroxidase (GPx) and catalase (CAT) activities.	Creatinine	23-33	catalase	Rattus norvegicus	239-247
23229315-6	2014	The increase of plasma creatinine levels negatively correlated with renal antioxidant defenses including ascorbic acid (AA) and reduced glutathione (GSH) content as well as glutathione S-transferase (GST), glutathione peroxidase (GPx) and catalase (CAT) activities.	Creatinine	23-33	catalase	Rattus norvegicus	249-252
24959002-10	2014	A correlation was observed between TGF-beta, donor age, and preablation creatinine, but not body mass index (BMI).	Creatinine	72-82	transforming growth factor beta 1	Homo sapiens	35-43
24469713-10	2014	We observed also that the decrease of the serum Adiponectin level was accompanied by an insulin resistance, albuminuria, as well as an increase of serum creatinine.	Creatinine	153-163	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
24618238-7	2014	In patients with DM2 and a creatinine clearance &lt; 60 ml/min/1.73 m2 certain anti-diabetic drugs are contraindicated, while others should be dose-adjusted.	Creatinine	27-37	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
25376659-7	2014	RESULTS: There was a greater increase in serum creatinine in IL-10(-/-) mice than in wild-type (WT) mice.	Creatinine	47-57	interleukin 10	Mus musculus	61-66
24878981-8	2014	Plasma adrenomedullin and CGRP correlated significantly negatively with serum creatinine and positively with mean 24 hours arterial blood pressure in patients with diabetes mellitus but not in control subjects.	Creatinine	78-88	calcitonin related polypeptide alpha	Homo sapiens	26-30
24330222-6	2013	The urinary protein/creatinine ratio was &gt;=0.2 g/gCr in 13 children, including 1 elementary and 12 junior high children.	Creatinine	20-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	52-55
24927378-8	2014	In TS patients, the numbers of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(+) T cells were positively correlated with eGFR and serum Cr levels, respectively.	Creatinine	134-136	CD4 molecule	Homo sapiens	31-34
24927378-8	2014	In TS patients, the numbers of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(+) T cells were positively correlated with eGFR and serum Cr levels, respectively.	Creatinine	134-136	CD4 molecule	Homo sapiens	57-60
24655996-7	2014	RESULTS: The urinary AGT-to-Cr ratio of the renal transplant recipients was significantly higher than that of the renal transplant donors (P = .0143).	Creatinine	28-30	angiotensinogen	Homo sapiens	21-24
24655996-8	2014	Furthermore, the urinary AGT-to-Cr ratio had a significantly positive correlation with the urinary albumin-to-Cr ratio (ACR; r = 0.39, P &lt; .0001), while on the other hand, it had a significantly negative correlation with estimated glomerular filtration rate (eGFR; r = -0.31, P = .0002).	Creatinine	32-34	angiotensinogen	Homo sapiens	25-28
24655996-8	2014	Furthermore, the urinary AGT-to-Cr ratio had a significantly positive correlation with the urinary albumin-to-Cr ratio (ACR; r = 0.39, P &lt; .0001), while on the other hand, it had a significantly negative correlation with estimated glomerular filtration rate (eGFR; r = -0.31, P = .0002).	Creatinine	110-112	angiotensinogen	Homo sapiens	25-28
24353253-0	2013	Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.	Creatinine	16-26	insulin	Homo sapiens	6-15
24353253-0	2013	Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.	Creatinine	16-26	insulin	Homo sapiens	55-85
24353253-2	2013	A urine C-peptide creatinine ratio (UCPCR) can be posted from home unaided.	Creatinine	18-28	insulin	Homo sapiens	8-17
24379826-9	2013	When analyzed for association with cardiovascular-renal disease risk factors, conditional on SLC2A9 SNPs strongly associated with SUA, significant associations were found for SLC2A9 SNPs with BMI, body weight, and waist circumference (p &lt; 1.4 x 10(-3)) and suggestive associations with albumin-creatinine ratio and total antioxidant status (TAS).	Creatinine	297-307	solute carrier family 2 member 9	Homo sapiens	175-181
24282531-11	2013	The creatinine(Cr)-corrected concentrations of TFF3 in urine were 367.1 ng/mg Cr, 910.6 ng/mg Cr, 1,149.0 ng/mg Cr, 1,610.0 ng/mg Cr and 3,475.0 ng/mg Cr for CKD stages 1-5, respectively.	Creatinine	4-14	trefoil factor 3	Homo sapiens	47-51
23222881-8	2013	L-PGDS was higher in the subjects with severe obstructive sleep apnoea (median 784.7 ng per mg of creatinine, n = 23) than in control subjects (262.1 ng per mg of creatinine, n = 16; p = 0.004) and in those with moderate obstructive sleep apnoea (371.7 ng per mg of creatinine, n = 25; p = 0.0008).	Creatinine	98-108	prostaglandin D2 synthase	Homo sapiens	0-6
23222881-8	2013	L-PGDS was higher in the subjects with severe obstructive sleep apnoea (median 784.7 ng per mg of creatinine, n = 23) than in control subjects (262.1 ng per mg of creatinine, n = 16; p = 0.004) and in those with moderate obstructive sleep apnoea (371.7 ng per mg of creatinine, n = 25; p = 0.0008).	Creatinine	163-173	prostaglandin D2 synthase	Homo sapiens	0-6
23222881-8	2013	L-PGDS was higher in the subjects with severe obstructive sleep apnoea (median 784.7 ng per mg of creatinine, n = 23) than in control subjects (262.1 ng per mg of creatinine, n = 16; p = 0.004) and in those with moderate obstructive sleep apnoea (371.7 ng per mg of creatinine, n = 25; p = 0.0008).	Creatinine	163-173	prostaglandin D2 synthase	Homo sapiens	0-6
24303898-7	2013	We found significantly positive correlations between CRP and creatinine titers in serum in all 101 CA patients.	Creatinine	61-71	C-reactive protein	Homo sapiens	53-56
23605174-8	2013	Patients with sclerostin levels above median were characterized by older age, higher haemoglobin and creatinine level and lower bsAP concentration.	Creatinine	101-111	sclerostin	Homo sapiens	14-24
23932765-5	2013	Results of the study suggested that CRP is present in urine of dogs with leishmaniasis and renal damage since uCRP/creatinine ratio was significantly increased in dogs with proteinuria, being the highest values observed in dogs with proteinuria and elevated sCr, and that the measurement of uCRP could be a tool to detect and evaluate the possible kidney damage associated with this disease.	Creatinine	115-125	C-reactive protein	Canis lupus familiaris	36-39
24225845-4	2013	Individuals identified as B12 deficient by definition 2 were more likely to manifest peripheral neuropathy OR (odds) (95% confidence intervals), p value: 9.70 (2.24, 42.07), 0.004 and report greater total disability, 19.61 (6.22, 61.86) 0.0001 after adjustments for age, sex, race, serum creatinine, and ferritin concentrations, smoking, diabetes, and peripheral artery disease.	Creatinine	288-298	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
24251953-9	2013	Baseline levels of copeptin correlated with NYHA functional class (r = 0.46; p = 0.01), 6 minute walking distance (r = -0.26; p = 0.04), NT-proBNP (r = 0.49, p = 0.01), creatinine (r = 0.39, p = 0.01) and estimated glomerular filtration rate (r = -0.32, p = 0.01).	Creatinine	169-179	arginine vasopressin	Homo sapiens	19-27
24215445-7	2013	Plasma PTX3 was accordingly associated negatively with BMI and WC, independently of age and plasma creatinine.	Creatinine	99-109	pentraxin 3	Homo sapiens	7-11
23521574-3	2013	Patients with nephropathy (39.6%) presented higher MPO levels that correlate positively with the albumin/creatinine ratio (r = 0.59, p&lt;0.05).	Creatinine	105-115	myeloperoxidase	Homo sapiens	51-54
24028898-2	2013	DESIGN AND METHODS: The eGFR automatic reporting, as assessed by Modification of Diet in Renal Disease (MDRD) and/or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equations, was evaluated in a representative cross-sectional sample.	Creatinine	177-187	epidermal growth factor receptor	Homo sapiens	24-28
24229668-6	2013	RESULTS: In the multiple linear regression model, natural log-transformed CRP (lnCRP) and uric acid were independent predictors of natural log-transformed urinary albumin to creatinine ratio (lnACR) (beta = 0.18, 95% CI 0.10-0.27, P &lt; 0.001 and beta = 0.18, 95% CI 0.09-0.27, P &lt; 0.001).	Creatinine	174-184	C-reactive protein	Homo sapiens	74-77
24026551-4	2013	RESEARCH DESIGN AND METHODS: We assessed the relationship between insulin sensitivity at baseline and development of early phenotypes of DN-microalbuminuria (albumin-creatinine ratio [ACR] &gt;=30 mg/g) and rapid renal function decline (glomerular filtration rate [GFR] loss &gt;3 mL/min/1.73 m2 per year)-with three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations over 6 years.	Creatinine	166-176	insulin	Homo sapiens	66-73
24037968-4	2013	By optimizing the analytical conditions it was found that the LOD of the proposed method was 87 muM creatinine, close to the normal human serum levels that are in the range of 60 to 100 muM.	Creatinine	100-110	latexin	Homo sapiens	96-99
24037968-4	2013	By optimizing the analytical conditions it was found that the LOD of the proposed method was 87 muM creatinine, close to the normal human serum levels that are in the range of 60 to 100 muM.	Creatinine	100-110	latexin	Homo sapiens	186-189
24037968-6	2013	The test can be used to distinguish patients with renal insufficiency (creatinine levels &gt;100 muM) from healthy persons.	Creatinine	71-81	latexin	Homo sapiens	97-100
24286516-12	2013	The LL37 levels were positively correlated with the IFN-alpha levels, and both LL37 and IFN-alpha levels showed a positive correlation with serum creatinine and no correlation with complement C3.	Creatinine	146-156	cathelicidin antimicrobial peptide	Homo sapiens	79-83
24286516-12	2013	The LL37 levels were positively correlated with the IFN-alpha levels, and both LL37 and IFN-alpha levels showed a positive correlation with serum creatinine and no correlation with complement C3.	Creatinine	146-156	interferon alpha 1	Homo sapiens	88-97
24144241-8	2013	RESULTS: Angiopoietin-1 pretreatment of eEOCs significantly reduced serum creatinine in cell-injected mice.	Creatinine	74-84	angiopoietin 1	Mus musculus	9-23
24228115-7	2013	RESULTS: Blood urea nitrogen and serum creatinine levels were statistically significant high in the group of IAP= 10 and 20cmH2O as compared with the IAP= 0cmH2O.	Creatinine	39-49	intracisternal A particle, Eya1 linked	Mus musculus	109-113
24147206-7	2013	RESULTS: In models of multiple linear regression, sex hormone-binding globulin, fasting insulin (inverse) and, in men, age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.	Creatinine	253-263	adiponectin, C1Q and collagen domain containing	Homo sapiens	172-183
24247793-6	2013	The up-regulated mTOR activity was significantly correlated with serum creatinine levels and interstitial fibrosis but not with proteinuria levels.	Creatinine	71-81	mechanistic target of rapamycin kinase	Homo sapiens	17-21
23887638-8	2013	On multiple linear regression analysis, elevated serum FGF21 level in women was an independent risk factor for increased carotid IMT (P=0.039), together with age (P&lt;0.001) and hypertension (P=0.011), in a model comprising also waist circumference, smoking history, serum creatinine, high sensitive C-reactive protein, dysglycemia, and dyslipidemia (adjusted R(2)=35.8%; P&lt;0.001).	Creatinine	274-284	fibroblast growth factor 21	Homo sapiens	55-60
23729627-0	2013	The influence of non-specificity of the creatinine assay on eGFR.	Creatinine	40-50	epidermal growth factor receptor	Homo sapiens	60-64
23747959-1	2013	OBJECTIVES: The aim of this paper was to compare the agreement between creatinine measured by Jaffe and enzymatic methods and their putative influence on eGFR as calculated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation in healthy and diabetic individuals.	Creatinine	71-81	epidermal growth factor receptor	Homo sapiens	154-158
24178969-8	2014	Albumin/creatinine ratio increased over time in the insulin-sensitization group (P value for trend&lt;0.001) and was stable in the insulin-provision group.	Creatinine	8-18	insulin	Homo sapiens	52-59
24178969-9	2014	Risk for progression of albumin/creatinine ratio was higher in the insulin-sensitization group compared with the insulin-provision group (odds ratio, 1.59; 95% confidence interval, 1.25 to 2.02; P=0.02).	Creatinine	32-42	insulin	Homo sapiens	67-74
24178969-12	2014	CONCLUSION: Over 5 years, despite lower glycated hemoglobin levels, the insulin-sensitization treatment group had greater progression of albumin/creatinine ratio compared with the insulin-provision treatment group.	Creatinine	145-155	insulin	Homo sapiens	72-79
24045636-7	2013	The serum creatinine levels remained at low levels in the Adv-IKK2dn-CD4+CD25- T cell-treated group.	Creatinine	10-20	CD4 molecule	Homo sapiens	69-72
24157497-7	2013	Compared with placebo, only ACE inhibitors significantly reduced the doubling of serum creatinine levels (odds ratio 0.58, 95% credible interval 0.32 to 0.90), and only beta blockers showed a significant difference in mortality (odds ratio 7.13, 95% credible interval 1.37 to 41.39).	Creatinine	87-97	angiotensin I converting enzyme	Homo sapiens	28-31
23515495-1	2013	We aimed to find the relationship between serum transforming growth factor beta 1(TGF-beta(1)) and urinary monocyte chemoattractant protein-1 (MCP-1) throughout the course of diabetic nephropathy (DN) and to assess the relationship between both levels and other parameters of renal injury such as albumin/creatinine ratio and estimated glomerular filtration rate (eGFR).	Creatinine	305-315	transforming growth factor beta 1	Homo sapiens	48-81
23515495-1	2013	We aimed to find the relationship between serum transforming growth factor beta 1(TGF-beta(1)) and urinary monocyte chemoattractant protein-1 (MCP-1) throughout the course of diabetic nephropathy (DN) and to assess the relationship between both levels and other parameters of renal injury such as albumin/creatinine ratio and estimated glomerular filtration rate (eGFR).	Creatinine	305-315	transforming growth factor beta 1	Homo sapiens	82-93
23990681-4	2013	Dialysate VEGF-C concentration correlated positively with the dialysate-to-plasma ratio of creatinine (D/P Cr) and the dialysate TGF-beta1 concentration.	Creatinine	91-101	vascular endothelial growth factor C	Homo sapiens	10-16
22789557-4	2013	The total NGF levels (pg/mL) were further normalized to the concentration of urinary creatinine (NGF/Cr level).	Creatinine	85-95	nerve growth factor	Homo sapiens	97-100
24094290-5	2013	Being consistent with lacking anti-inflammatory activity, apoA-I was linearly and positively associated with apoB, in women further with creatinine.	Creatinine	137-147	apolipoprotein A1	Homo sapiens	58-64
24094290-8	2013	CONCLUSION: Elevated creatinine levels within normal range, linked to apoA-I dysfunctionality, are independently associated with CHD likelihood even in non-diabetic subjects without MetS.	Creatinine	21-31	apolipoprotein A1	Homo sapiens	70-76
23899407-6	2013	Hcy only correlated with serum creatinine but big ET-1 significantly correlated with serum creatinine, UPC ratio, systolic blood pressure, and increased CRP.	Creatinine	91-101	endothelin 1	Canis lupus familiaris	50-54
23611517-6	2013	Serum creatinine at time of diagnosis had significant correlation with proteinuria (p = 0.02), urinary levels of IL-1beta (p = 0.03), IL-2 (p = 0.01) and MCP-1 (p = 0.03).	Creatinine	6-16	interleukin 1 beta	Homo sapiens	113-121
23625296-10	2013	There was a moderate negative correlation between the ratio of microalbumin/creatinine and the number of CD34+ cells.	Creatinine	76-86	CD34 molecule	Homo sapiens	105-109
23611517-6	2013	Serum creatinine at time of diagnosis had significant correlation with proteinuria (p = 0.02), urinary levels of IL-1beta (p = 0.03), IL-2 (p = 0.01) and MCP-1 (p = 0.03).	Creatinine	6-16	interleukin 2	Homo sapiens	134-138
24052915-2	2013	The Randomized Evaluation of Long-Term Anticoagulation Therapy (RELY) trial demonstrated that dabigatran, a direct thrombin inhibitor, was associated with lower rates of systemic embolism compared to warfarin.1 Although individuals with a creatinine clearance of less than 30 mL/min were excluded from the trial, the FDA approved the use of dabigatran for those with creatinine clearances as low as 15 mL/min, with a lower dose of dabigatran recommended for individuals with creatinine clearances below 30 mL/min.	Creatinine	239-249	coagulation factor II, thrombin	Homo sapiens	115-123
23834818-9	2013	Cystatin C was independently associated with cardiovascular events (hazard ratio 1.50 (95% CI: 1.27-1.77)) and all-cause mortality (hazard ratio 1.62 (95% CI: 1.38-1.90)).Creatinine was only associated with all-cause mortality, while eGFR was not associated with any of the outcomes.	Creatinine	171-181	epidermal growth factor receptor	Homo sapiens	234-238
23790335-10	2013	There was certain correlation between the protein expression of TLR4 and the increased serum titer of 24-hour urine protein excretion, serum creatinine, CRP and TNF-alpha.	Creatinine	141-151	toll-like receptor 4	Rattus norvegicus	64-68
23656889-5	2013	Our results show that the albumin-to-creatinine ratio significantly decreased in diabetic KCa3.1(-/-) mice compared with diabetic wild-type mice and in diabetic eNOS(-/-) mice treated with TRAM34 compared with diabetic mice.	Creatinine	37-47	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	90-96
23828733-5	2013	The probability of PTH spikes was analyzed regarding preoperative PTH- and creatinine levels, and size of adenoma and their impact on the Vienna, Miami, and Halle criteria was evaluated.	Creatinine	75-85	parathyroid hormone	Homo sapiens	19-22
22503569-8	2013	Significant multivariate independent predictors of decreased creatinine included higher baseline serum creatinine levels (adjusted OR per quartile increment, 2.5 [1.3 to 4.7], p=0.004) and lower C-reactive protein levels (adjusted OR per quartile increment 0.39 [0.19 to 0.82], p=0.013).	Creatinine	61-71	C-reactive protein	Homo sapiens	195-213
23523991-7	2013	Selective MOP receptor antagonist beta-funaltrexamine (FNA) also suppressed the renal ischemia/reperfusion-induced increases in BUN and plasma creatinine.	Creatinine	143-153	opioid receptor, mu 1	Mus musculus	10-22
23861858-2	2013	We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post-transplant serum creatinine when compared to "Gold Standard" clinical factors, such as cold ischaemic time and donor chronological age.	Creatinine	131-141	cyclin dependent kinase inhibitor 2A	Homo sapiens	37-43
23552866-8	2013	The therapeutic effect of the anti-TGF-beta antibody was further confirmed by its prevention of graft dysfunction, indicated by lower levels of serum creatinine and blood urea nitrogen or higher creatinine clearance in anti-TGF-beta antibody-treated recipients compared with those in control recipients (P &lt; 0.05).	Creatinine	150-160	transforming growth factor, beta 1	Rattus norvegicus	35-43
23552866-8	2013	The therapeutic effect of the anti-TGF-beta antibody was further confirmed by its prevention of graft dysfunction, indicated by lower levels of serum creatinine and blood urea nitrogen or higher creatinine clearance in anti-TGF-beta antibody-treated recipients compared with those in control recipients (P &lt; 0.05).	Creatinine	195-205	transforming growth factor, beta 1	Rattus norvegicus	35-43
23813704-7	2013	In fully adjusted models, the odds ratio for insulin resistance was 0.45 (95% confidence interval: 0.28, 0.74) among women in the highest quartile of urinary 6-sulfatoxymelatonin:creatinine ratio compared with women in the lowest quartile.	Creatinine	179-189	insulin	Homo sapiens	45-52
23518194-14	2013	CONCLUSIONS: The strong association of cystatin C level with mortality compared with serum creatinine estimates is shared by BTP and B2M.	Creatinine	91-101	prostaglandin D2 synthase	Homo sapiens	125-128
23702231-8	2013	Serum creatinine and BNP were also significantly lower in the hANP group at 1 year postoperatively.	Creatinine	6-16	natriuretic peptide A	Homo sapiens	62-66
23637043-4	2013	At 24 h after LPS injection, renal glomerular hypercellularity and hepatocellular injury were observed in both strains, accompanying further elevated serum levels of creatinine and alanine aminotransferase in TRPV1(-/-) mice compared to those in WT mice.	Creatinine	166-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	209-214
23378622-6	2013	L-FABP was measured by ELISA and normalized with urinary creatinine.	Creatinine	57-67	fatty acid binding protein 1	Homo sapiens	0-6
23413806-7	2013	In addition, recent work has demonstrated that C-peptide is more stable in blood than previously suggested or can be reliably measured on a spot urine sample (urine C-peptide:creatinine ratio), facilitating measurement in routine clinical practice.	Creatinine	175-185	insulin	Homo sapiens	47-56
23425644-9	2013	CONCLUSION: The calcium:creatinine clearance ratio (CCCR) is the consensus biochemical test to differentiate between PHPT and FHH.	Creatinine	24-34	calcium sensing receptor	Homo sapiens	126-129
23766538-6	2013	Assessed at 18 hours after reperfusion, Slit2 significantly inhibited renal tubular necrosis, neutrophil and macrophage infiltration, and rise in plasma creatinine.	Creatinine	153-163	slit guidance ligand 2	Mus musculus	40-45
23269570-13	2013	For patients with renal amyloidosis and other forms of glomerulonephritis who initially had normal creatinine levels, tumor necrosis factor (TNF)-alpha blocker therapy resolved proteinuria, but this was not the case for patients with initial renal insufficiency.	Creatinine	99-109	tumor necrosis factor	Homo sapiens	118-151
24284182-12	2013	CONCLUSIONS: eGFR level in CAD patients with normal serum creatinine is associated with coronary artery severity, inflammation level and serves as an independent predictor for MACCE in this patient cohort.	Creatinine	58-68	epidermal growth factor receptor	Homo sapiens	13-17
23536133-6	2013	In comparing the highest to lowest tertiles, the odds ratio for having early renal function decline was 2.70 (CI: 1.15, 6.32) using the haptoglobin to creatinine ratio compared with 2.50 (CI 1.14, 5.48) using the albumin to creatinine ratio after adjusting for treatment group and use of ACE inhibitors.	Creatinine	151-161	haptoglobin	Homo sapiens	136-147
23536133-6	2013	In comparing the highest to lowest tertiles, the odds ratio for having early renal function decline was 2.70 (CI: 1.15, 6.32) using the haptoglobin to creatinine ratio compared with 2.50 (CI 1.14, 5.48) using the albumin to creatinine ratio after adjusting for treatment group and use of ACE inhibitors.	Creatinine	224-234	haptoglobin	Homo sapiens	136-147
23536133-7	2013	Addition of the haptoglobin to creatinine ratio to a model using the albumin to creatinine ratio to predict early renal function decline resulted in improved predictive performance.	Creatinine	80-90	haptoglobin	Homo sapiens	16-27
23407997-10	2013	L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively.	Creatinine	33-43	fatty acid binding protein 1	Homo sapiens	0-6
23792525-7	2013	Creatinine concentrations 36 and 48 months after transplantation were higher among CC homozygotes of the rs1041163 VCAM1 (TT+CT vs. CC, p=0.049 and p=0.04, respectively).	Creatinine	0-10	vascular cell adhesion molecule 1	Homo sapiens	115-120
21925746-7	2013	RESULTS: NGT &lt; 155 subjects into upper tertile of 1-h post-load insulin had a worse lipemic profile, a higher hs-CRP, creatinine, LVM, e-GFR and IMT.	Creatinine	121-131	insulin	Homo sapiens	67-74
23619263-5	2013	IGF-I levels were positively correlated with IGFBP-3 and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR and aPTT ratio.	Creatinine	115-125	insulin like growth factor 1	Homo sapiens	0-5
23075028-14	2013	ICTP correlated with the basal, mid, and apical anterolateral SR, as well as apical anterior and inferior SR. PCIP correlated with mid anterolateral, basal anteroseptal, and mid inferolateral SR. TGF-beta correlated with apical inferior SR. Cr correlated with mid inferior-septal and apical lateral SR. 6 MWT negatively correlated with the apical anterior septum SR.	Creatinine	241-243	transforming growth factor beta 1	Homo sapiens	196-204
23289766-3	2013	Postprandial urinary C-peptide creatinine ratio (UCPCR) is a non-invasive measure of endogenous insulin secretion that has not been tested as a diagnostic tool in children or in patients with diabetes duration &lt;5 yr. We aimed to assess whether UCPCR can discriminate type 1 diabetes from MODY and type 2 in pediatric diabetes.	Creatinine	31-41	insulin	Homo sapiens	96-103
22336249-10	2013	Fasting insulin interacts with creatinine in explaining LVM variability: 0.1mg/dL increase in creatinine produces an increase of 8.1g/m(2) in LVMI in patients with higher plasma insulin (upper quartiles).	Creatinine	31-41	insulin	Homo sapiens	178-185
22336249-10	2013	Fasting insulin interacts with creatinine in explaining LVM variability: 0.1mg/dL increase in creatinine produces an increase of 8.1g/m(2) in LVMI in patients with higher plasma insulin (upper quartiles).	Creatinine	94-104	insulin	Homo sapiens	8-15
22336249-10	2013	Fasting insulin interacts with creatinine in explaining LVM variability: 0.1mg/dL increase in creatinine produces an increase of 8.1g/m(2) in LVMI in patients with higher plasma insulin (upper quartiles).	Creatinine	94-104	insulin	Homo sapiens	178-185
23508044-8	2013	Proteinurea and serum creatinine levels were significantly reduced in animals with reduced Hic-5 expression.	Creatinine	22-32	transforming growth factor beta 1 induced transcript 1	Rattus norvegicus	91-96
23481506-6	2013	The VWF-pp/ADAMTS13 ratio significantly correlated with Acute Physiology and Chronic Health Evaluation II score on days 1 and 5; Sepsis-related Organ Failure Assessment score on days 1, 3, and 5; maximum Sepsis-related Organ Failure Assessment score and tumor necrosis factor alpha level on days 1, 3, 5, and 7; and creatinine level on days 1, 5, and 7.	Creatinine	316-326	von Willebrand factor	Homo sapiens	4-7
23677265-10	2013	Treatment of pregnant rats with anti TNF-alpha antibodies, restored urine volume, creatinine clearance, plasma ET-1, serum IL-6 and sVCAM-1 to normal levels.	Creatinine	82-92	tumor necrosis factor	Rattus norvegicus	37-46
23541028-0	2013	Formation of [Ni(III)(kappa(1)-S2CH)(P(o-C6H3-3-SiMe3-2-S)3)]- via CS2 insertion into nickel(III) hydride containing [Ni(III)(H)(P(o-C6H3-3-SiMe3-2-S)3)]-.	Creatinine	96-105	chorionic somatomammotropin hormone 2	Homo sapiens	67-70
23778338-11	2013	Furthermore, the gene expression of B-cell lymphoma 2 correlated with the warm ischemia time in the open group (p = 0.047) and that of vascular endothelial growth factor with the area under the curve for creatinine in the laparoscopic group (p = 0.01).	Creatinine	204-214	vascular endothelial growth factor A	Homo sapiens	135-169
22739771-6	2013	AGT rs11568054 minor allele carriers had more frequent history of renal disease (P=0.04) and higher plasma creatinine (P=0.033).	Creatinine	107-117	angiotensinogen	Homo sapiens	0-3
22527186-5	2013	A comparison of 6-month continuation of S-1 stratified by various clinical factors, using the log-rank test, revealed a marginally significant difference in creatinine clearance (CCr) between those patients who continued for 6 months and those who did not.	Creatinine	157-167	proteasome 26S subunit, non-ATPase 1	Homo sapiens	40-43
22527186-10	2013	CONCLUSIONS: CCr &lt;60 ml/min was a significant risk factor for 6-month continuation of S-1 adjuvant chemotherapy, even though the renal function was judged as normal by the serum creatinine level.	Creatinine	181-191	proteasome 26S subunit, non-ATPase 1	Homo sapiens	89-92
23403929-10	2013	The serum Cr was positively correlated to BNP levels in the model group.	Creatinine	10-12	natriuretic peptide B	Rattus norvegicus	42-45
22633987-8	2013	Serum creatinine had a curvilinear relation with serum albumin and prealbumin.	Creatinine	6-16	albumin	Homo sapiens	49-62
23054318-7	2013	Inferior creatinine clearance was observed in dTAC-IL2-RA Group compared to TAC-IL2-RA and TAC-No Groups at months 1 (41.6 vs. 49.9 vs. 44.8 mL/min, p = 0.004), 3 (49.8 vs. 57.2 vs. 53.5 mL/min, p = 0.017), and 6 (53.1 vs. 61.8 vs. 57.0 mL/min, p = 0.001).	Creatinine	9-19	interleukin 2	Homo sapiens	51-54
23084283-7	2013	Serum creatinine in high cre/hANP (+) got to decrease more than high cre/hANP (-).	Creatinine	6-16	natriuretic peptide A	Homo sapiens	29-33
23084283-7	2013	Serum creatinine in high cre/hANP (+) got to decrease more than high cre/hANP (-).	Creatinine	6-16	natriuretic peptide A	Homo sapiens	73-77
26105881-7	2013	In pregnancy, plasma ACE levels were related to protein/creatinine (r=0.29, P=0.036, n=54).	Creatinine	56-66	angiotensin I converting enzyme	Homo sapiens	21-24
26105881-8	2013	Urinary protein/creatinine was not related to iRAS activity (males and non-pregnant females) but in pregnancy was related to prorenin and active renin/creatinine (r=0.45, P=0.02, n=26 r=0.47, P&lt;0.001, n=50).	Creatinine	16-26	renin	Homo sapiens	128-133
26105881-9	2013	Urinary albumin/creatinine was related to uAGT and active renin/creatinine in pregnancy (r=0.39, P=0.005, n=51; r=0.37, P=0.008, n=51).	Creatinine	16-26	renin	Homo sapiens	58-63
23622592-11	2013	Both urinary AGT-urinary creatinine ratio (UAGT/UCr) and urinary protein-urinary creatinine ratio (UPro/UCr) were higher in kidney transplant patients than in healthy volunteers (P &lt; .01; P &lt; .0001; respectively).	Creatinine	25-35	angiotensinogen	Homo sapiens	13-16
23482786-6	2013	RESULTS: p53 expression was significantly correlated with patients who were undergoing hemodialysis (p=0.005) and had increased serum creatinine levels (p=0.001).	Creatinine	134-144	tumor protein p53	Homo sapiens	9-12
23040261-5	2013	Stepwise regression analysis showed significant associations (R(2)=.264) of circulating log(e)CRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure.	Creatinine	188-198	C-reactive protein	Homo sapiens	94-97
23279103-9	2013	Because only 5% of patients had a creatinine clearance between 30 and 50 mL min(-1), further data are needed in such patients.	Creatinine	34-44	CD59 molecule (CD59 blood group)	Homo sapiens	76-82
22739771-8	2013	ACE rs4267385 was associated with older clinical coronary disease onset (P=0.008) and hypertension (P=0.013) onset, increased plasma creatinine (P=0.01), yet greater mortality (P=0.044).	Creatinine	133-143	angiotensin I converting enzyme	Homo sapiens	0-3
27818745-2	2013	This system relies on changes in the serum creatinine (SCr) or glomerular filtration rates and/or urine output, and it has been largely demonstrated that the RIFLE criteria allows the identification of a significant proportion of AKI patients hospitalized in numerous settings, enables monitoring of AKI severity, and is a good predictor of patient outcome.	Creatinine	43-53	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	158-163
24133631-10	2013	On the other hand, the growth rate of the enlarged HCCs was significantly correlated with CDDP dose after normalization with creatinine clearance.	Creatinine	125-135	holocytochrome c synthase	Homo sapiens	51-55
23294625-6	2013	RESULTS: We observed a positive correlation of fibulin-1 levels with age (r = 0.38; p = 0.033), glycated hemoglobin (r = 0.80; p = 0.003), creatinine (r = 0.35; p = 0.045), and fibrinogen (r = 0.39; p = 0.027).	Creatinine	139-149	fibulin 1	Homo sapiens	47-56
23174859-6	2013	Creatinine clearance (Ccr) was reduced in male MatSep rats compared with control rats at baseline and after ANG II infusion.	Creatinine	0-10	angiotensinogen	Rattus norvegicus	108-114
23294625-9	2013	In a multivariable regression model, diabetes, creatinine, fibrinogen and central augmentation pressure were independent predictors of plasma fibulin-1.	Creatinine	47-57	fibulin 1	Homo sapiens	142-151
24364044-10	2013	Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test.	Creatinine	71-81	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
23152109-5	2013	Serum creatinine levels were higher 24 h after LPS injection in TRPV1(-/-) than in WT mice.	Creatinine	6-16	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
23363891-9	2013	Significantly higher rates of decline in creatinine clearance were noted in patients with TNF-alpha (rs1800629) GA+AA than GG genotype (0.88 +- 1.83 vs. 0.36 +- 0.70, p = 0.03), and with IL-10 (rs1800896) AG+GG than AA genotype (1.28 +- 2.14 vs. 0.33 +- 0.90, p &lt; 0.001).	Creatinine	41-51	tumor necrosis factor	Homo sapiens	90-99
24356308-4	2013	Correlation between CAF and creatinine concentrations/eGFR was calculated as within-patient (cWP) and between-patient correlations (cBP).	Creatinine	28-38	CREB binding protein	Homo sapiens	132-135
23282228-9	2013	Fetuin-A levels showed significant negative correlations with serum creatinine, hsCRP, CRI, IMT and ABI in SLE patients with and without LN.	Creatinine	68-78	alpha 2-HS glycoprotein	Homo sapiens	0-8
23152109-12	2013	Thus TRPV1 gene ablation exacerbates LPS-induced renal tissue and function injury, including aggravated renal neutrophil and macrophage infiltration, chemokine and adhesion molecule levels, and glomerular hypercellularity accompanying with further increased serum creatinine and cytokine levels.	Creatinine	264-274	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	5-10
23679242-6	2013	A significant correlation was observed between serum levels of AFP (P&lt;0.001) and CA15-3 (P&lt;0.001) and also a tendency between creatinine clearance and CEA (r=0.05, P=0.625).	Creatinine	132-142	CEA cell adhesion molecule 3	Homo sapiens	157-160
23679242-7	2013	Creatinine clearance significantly correlated with AFP (P&lt;0.001, r=0.53) and CA15-3 (p=0.00, r=-0.412), but not CA19-9 (P=0.089, r=-0.171).	Creatinine	0-10	alpha fetoprotein	Homo sapiens	51-54
23066919-12	2013	In patients with creatinine clearance &lt;50 mL/min, dosage reduction should be considered from the initiation of S-1 treatment.	Creatinine	17-27	proteasome 26S subunit, non-ATPase 1	Homo sapiens	114-117
23558676-7	2013	We conjecture that changes in renal function and serum albumin (Alb) accompanying transplant progress are aggravating factors in terms of estimation, because there was also a significant difference in the reciprocal of serum creatinine (1/Scr) and Alb between pre-Tx and post-Tx in this study.	Creatinine	225-235	albumin	Homo sapiens	64-67
22635246-4	2013	CKD was defined as a persistent decrease in the Cr-based estimated glomerular filtration rate to below 60 mL/min/1.73 m2.	Creatinine	48-50	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
23865349-6	2013	The intraclass correlation coefficient (ICC) of eGFR when the creatinine was measured by the picric acid method was significantly lower than that of the enzymatic method.	Creatinine	62-72	epidermal growth factor receptor	Homo sapiens	48-52
24055914-8	2013	Serum creatinine decreased from 1200 to 170mumol/L 57 with eGFR improving from 4 to 38mL/min/1.73m(2) at four weeks post-transplant.	Creatinine	6-16	epidermal growth factor receptor	Homo sapiens	59-63
23689573-10	2013	In the group treated with angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, the following factors were identified as risk factors for experiencing a 50% increase in serum creatinine over the baseline: a baseline eGFR &lt;60 ml/min, proteinuria &gt;1 g/day during the follow-up period, glomerular sclerosis &gt;grade 1, and tubulointerstitial lesions &gt;stage 1.	Creatinine	191-201	epidermal growth factor receptor	Homo sapiens	232-236
23481058-8	2013	A high intensity of HIF-1alpha expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis.	Creatinine	83-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-30
24055914-8	2013	Serum creatinine decreased from 1200 to 170mumol/L 57 with eGFR improving from 4 to 38mL/min/1.73m(2) at four weeks post-transplant.	Creatinine	6-16	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
22941511-7	2013	The levels of plasma SC5b-9 and urinary C5a were positively correlated with the serum creatinine at presentation (r=0.56, P=0.01; r=0.68, P=0.02, respectively) and the percentage of crescents in glomeruli (r=0.60, P=0.005; r=0.75, P=0.005, respectively).	Creatinine	86-96	complement C5a receptor 1	Homo sapiens	40-43
24159603-10	2013	Urinary VEGF increased from 388 to 1346 pg/mg urinary creatinine (P &lt; 0.02) in the low-dose group but remained unchanged in the high-dose group.	Creatinine	54-64	vascular endothelial growth factor A	Homo sapiens	8-12
23796916-2	2013	METHODS: We explored the association of a functional polymorphism in the promoter region (rs1800629) of the TNFA gene with severity of AKI, as defined by level of glomerular filtration (serum cystatin C and creatinine) and tubular injury (urinary NAG, KIM-1, alpha-GST, and pi-GST) markers, in 262 hospitalized adults.	Creatinine	207-217	tumor necrosis factor	Homo sapiens	108-112
23796916-3	2013	RESULTS: In unadjusted analyses, compared with the GG genotype, the TNFA GA and AA genotype groups tended to have higher enrollment (p = 0.08), peak (p = 0.004), and discharge (p = 0.004) serum creatinine levels, and the AA genotype tended to have a higher enrollment serum cystatin C level (p = 0.04).	Creatinine	194-204	tumor necrosis factor	Homo sapiens	68-72
23796916-5	2013	After adjustment for sex, race, age, baseline estimated glomerular filtration rate, sepsis, and dialysis requirement, compared with the GG genotype, the TNFA minor A-allele group had a higher peak serum creatinine of 1.03 mg/dl (0.43, 1.63; p = 0.001) and a higher urinary KIM-1 (relative ratio: 1.73; 95% CI: 1.16, 2.59; p = 0.008).	Creatinine	203-213	tumor necrosis factor	Homo sapiens	153-157
23651488-7	2013	The correlation between NO2 + NO3 concentration and creatinine concentration in patients with HRS was significantly higher compared to patients without HRS (HRS = 0.82; cirrhosis = 0.32; control = -0.25).	Creatinine	52-62	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
23544132-12	2013	We found that the level of exosomal WT1 were associated with a significant increase in urine protein-to-creatinine ratio, albumin-to-creatinine ratio, and serum creatinine as well as a decline in eGFR.	Creatinine	104-114	WT1 transcription factor	Homo sapiens	36-39
23544132-12	2013	We found that the level of exosomal WT1 were associated with a significant increase in urine protein-to-creatinine ratio, albumin-to-creatinine ratio, and serum creatinine as well as a decline in eGFR.	Creatinine	133-143	WT1 transcription factor	Homo sapiens	36-39
23544132-12	2013	We found that the level of exosomal WT1 were associated with a significant increase in urine protein-to-creatinine ratio, albumin-to-creatinine ratio, and serum creatinine as well as a decline in eGFR.	Creatinine	133-143	WT1 transcription factor	Homo sapiens	36-39
23441146-11	2013	Independent significant predictors of death in the multivariate analysis were the concentration of TRAIL (OR 0.053 (95% CI 0.004-0.744), p = 0.029), older age (OR 1.20 (95% CI 1.02-1.41, p = 0.026) and serum creatinine (OR 15.1 (95% CI 1.56-145.2), p = 0.0193).	Creatinine	208-218	TNF superfamily member 10	Homo sapiens	99-104
23441146-14	2013	The predictive value of TRAIL concentration is independent of age, ejection fraction, index peak troponin level, concentration of BNP or serum creatinine.	Creatinine	143-153	TNF superfamily member 10	Homo sapiens	24-29
23041443-10	2013	The c-Met levels of the HSPN group were positively correlated with the blood urea nitrogen and serum creatinine levels (P &lt; 0.01).	Creatinine	101-111	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
23504683-5	2013	Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated.	Creatinine	79-89	epidermal growth factor receptor	Homo sapiens	124-128
23206815-7	2012	In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects.	Creatinine	47-57	serpin family A member 12	Homo sapiens	151-157
23206815-8	2012	CONCLUSIONS: The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin Low group.	Creatinine	17-27	serpin family A member 12	Homo sapiens	76-82
23206815-8	2012	CONCLUSIONS: The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin Low group.	Creatinine	17-27	serpin family A member 12	Homo sapiens	156-162
23093265-8	2012	An eGFR formula derived from pooled studies analyzing both creatinine and cystatin C, and using a biology-based mathematical approach maybe advantageous.	Creatinine	59-69	epidermal growth factor receptor	Homo sapiens	3-7
23574756-5	2013	After adjustment for percentage body fat, HDL cholesterol and serum leptin, hemoglobin and creatinine-based eGFR remained independent predictors of adiponectin (standardized beta coefficient=-0.248, p&lt;0.0001, and -0.101, p=0.03, respectively).	Creatinine	91-101	adiponectin, C1Q and collagen domain containing	Homo sapiens	148-159
23651488-8	2013	By using binary regression analysis, on the basis of clinical criteria of HRS diagnosis, the strongest independent positive predictor for HRS development was NO2 + NO3, associated with 45.02 times higher incidence of HRS, compared to arginine (12.7 times higher incidence), creatinine (13.1 times higher incidence), and AST/ALT ratio (10.55 higher incidence of HRS).	Creatinine	274-284	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
22918154-7	2012	Low CD4 T-lymphocyte counts (&lt;200 cells/mm) were significantly associated with a greater urine protein to creatinine ratio in linear models and with proteinuria in logistic regression models.	Creatinine	109-119	CD4 molecule	Homo sapiens	4-7
22639068-6	2012	We found a significant correlation between NGAL, serum creatinine, cystatin C and eGFR.	Creatinine	55-65	epidermal growth factor receptor	Homo sapiens	82-86
22962322-9	2012	The vasopressin (+) group had higher urea and creatinine levels.	Creatinine	46-56	arginine vasopressin	Homo sapiens	4-15
23190703-9	2012	Interactions were found between HbA1c and both insulin resistance and the urinary albumin-to-creatinine ratio for the percentage of elevated fetuin-A levels (P(interaction) = 0.002 and 0.05, respectively).	Creatinine	93-103	alpha 2-HS glycoprotein	Homo sapiens	141-149
23144467-6	2012	The effect of fenofibrate treatment on serum FGF21, but not RBP4, remained significant after adjusting for fenofibrate-induced changes in glycosylated hemoglobin, total cholesterol, triglycerides, apolipoprotein A-II, fibrinogen, plasma creatinine, and homocysteine (P = 0.002).	Creatinine	237-247	fibroblast growth factor 21	Homo sapiens	45-50
22818840-1	2012	Beta-trace protein (BTP) is a low-molecular mass protein belonging to the lipocalin protein family, which is more sensitive than serum creatinine for detecting impaired renal function.	Creatinine	135-145	prostaglandin D2 synthase	Homo sapiens	0-18
22835948-6	2012	RESULTS: Long-term function was significantly better in recipients of an organ from donors carrying the ABCB1 1199A mutated allele (median and range creatinine values were 1.1 mg/dL [0.8-1.5mg/dL] in case of at least one ABCB1 1199A allele versus 1.5 mg/dL [0.7-3.7 mg/dL] for homozygous carriers of wild-type allele, P &lt; 0.01).	Creatinine	149-159	ATP binding cassette subfamily B member 1	Homo sapiens	104-109
22835948-7	2012	ABCB1 1199G&gt;A polymorphism and donor age had an independent impact on both serum creatinine and estimated glomerular filtration rate.	Creatinine	84-94	ATP binding cassette subfamily B member 1	Homo sapiens	0-5
22854890-10	2012	Positive correlations were observed between urinary podocalyxin levels and HbA(1c), urinary beta(2) microglobulin, alpha(1) microglobulin and urinary N-acetyl-beta-D-glucosaminidase, although urinary podocalyxin levels were not correlated with other laboratory markers such as blood pressure, lipid level, serum creatinine, estimated GFR or proteinuria.	Creatinine	312-322	podocalyxin like	Homo sapiens	52-63
22627199-6	2012	Soluble CXCL16 levels in gout subjects were closely correlated with renal function and lipid profiles, and independently associated with 24h proteinuria, creatinine clearance rate and C-reactive protein.	Creatinine	154-164	C-X-C motif chemokine ligand 16	Homo sapiens	8-14
23141854-8	2012	Mean cTnT value was 0.149 +- 0.484 ng/mL, and cTnT was directly correlated with serum creatinine (Spearman"s Rho = 0.35, P &lt; .001) and NYHA class (0.25, P &lt; .001).	Creatinine	86-96	troponin T2, cardiac type	Homo sapiens	46-50
22785177-3	2012	Compared to wild-type mice, cisplatin-treated IFN-gamma-deficient (IFN-gamma(-/-)) mice exhibited exaggerated histopathological changes with higher blood urea nitrogen and creatinine levels.	Creatinine	172-182	interferon gamma	Mus musculus	46-55
22785177-3	2012	Compared to wild-type mice, cisplatin-treated IFN-gamma-deficient (IFN-gamma(-/-)) mice exhibited exaggerated histopathological changes with higher blood urea nitrogen and creatinine levels.	Creatinine	172-182	interferon gamma	Mus musculus	67-76
22683425-7	2012	In multiple regression analysis, VEGF and kidney dysfunction markers (urea and creatinine levels) were independently associated with uPA, and VEGF was independently associated with suPAR levels.	Creatinine	79-89	plasminogen activator, urokinase	Homo sapiens	133-136
23078781-1	2012	INTRODUCTION: The Risk, Injury, Failure, Loss, and End-Stage Renal Disease (RIFLE) is a consensus-based classification system for diagnosing acute kidney insufficiency (AKI), based on serum creatinine (SCr) and urine output criteria (RIFLESCr+UO).	Creatinine	190-200	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	76-81
22859404-9	2012	Creatinine clearance was higher in P2X(7) KO mice than in WT mice (551.53 +- 65.23 vs. 390.85 +- 32.81 mul min(-1) g renal weight(-1)).	Creatinine	0-10	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	35-41
23057632-6	2012	In IF/TA groups, the expression of TIMP-1 was positively correlated to serum creatinine level (r = 0.718, P &lt; 0.05).	Creatinine	77-87	TIMP metallopeptidase inhibitor 1	Homo sapiens	35-41
22583371-5	2012	RESULTS: Expression of Notch 1 was correlated with acute rejection and long-term renal function after transplant (as detected by the level of serum creatinine 6 months after transplant).	Creatinine	148-158	notch receptor 1	Homo sapiens	23-30
22871893-7	2012	In addition to age and sex, 24-h urinary sodium excretion was an independent determinant of urinary angiotensinogen-to-creatinine ratio (P = 0.0008).	Creatinine	119-129	angiotensinogen	Homo sapiens	100-115
22871893-8	2012	Urinary angiotensinogen-to-creatinine ratio was 34% (P = 0.04) and 82% (P &lt;= 0.0001) higher in tertiles 2 and 3 of 24-h urinary sodium excretion, respectively, than in tertile 1.	Creatinine	27-37	angiotensinogen	Homo sapiens	8-23
22871893-9	2012	In multivariate analyses, urinary angiotensinogen-to-creatinine ratio was significantly and positively associated with clinic and ambulatory BP (P &lt;= 0.02) and the prevalence of ambulatory hypertension [odds ratio (95% confidence interval) associated with two-time increase, 1.24 (1.09-1.39); P = 0.0007].	Creatinine	53-63	angiotensinogen	Homo sapiens	34-49
22538126-9	2012	Moreover, the level of urinary aldosterone/creatinine after 8-week treatment was significantly lowered by treatment with BMP-6-KLH.	Creatinine	43-53	bone morphogenetic protein 6	Rattus norvegicus	121-126
22718188-4	2012	Both the urine KIM-1 and Gpnmb to creatinine ratios correlated with the urinary albumin to creatinine ratio, the duration of diabetes, and the stringency of glycemic control but not with blood pressure or baseline eGFR.	Creatinine	34-44	glycoprotein nmb	Homo sapiens	25-30
22718188-4	2012	Both the urine KIM-1 and Gpnmb to creatinine ratios correlated with the urinary albumin to creatinine ratio, the duration of diabetes, and the stringency of glycemic control but not with blood pressure or baseline eGFR.	Creatinine	91-101	glycoprotein nmb	Homo sapiens	25-30
22764191-14	2012	However, this elevated risk is captured by patient characteristics and eGFR at the last visit, suggesting that eGFR trajectories based on more than two serum creatinine measurements over a period longer than 1 year are required to determine ESRD risk and allow more reliable risk prediction.	Creatinine	158-168	epidermal growth factor receptor	Homo sapiens	111-115
22623021-11	2012	CONCLUSION: A correlation observed between HOMA-IR, age, blood pressure, serum creatinine (Cr) and triglyceride may suggest that insulin sensitivity will emerge as renal disease progresses.	Creatinine	79-89	insulin	Homo sapiens	129-136
22623021-11	2012	CONCLUSION: A correlation observed between HOMA-IR, age, blood pressure, serum creatinine (Cr) and triglyceride may suggest that insulin sensitivity will emerge as renal disease progresses.	Creatinine	91-93	insulin	Homo sapiens	129-136
22313585-22	2012	NMP22 was more frequently positive in urine with creatinine concentration &gt;2.5 g/L (OR 1.61, 95% CI 0.91-2.86).	Creatinine	49-59	nuclear mitotic apparatus protein 1	Homo sapiens	0-5
22935584-9	2012	Patients with creatinine clearance (CrCl) 50-80 ml min(-1) on OxCap(+- cetuximab) or OxFU+cetuximab had more dose modifications than those with better renal function.	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	51-57
27847452-5	2012	CCl4 caused elevated levels of urea and creatinine while it decreased levels of total protein and albumin in plasma.	Creatinine	40-50	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
22776430-3	2012	Intent-to-treat analysis showed the 1-year adjusted mean change from baseline in creatinine clearance (Cockcroft-Gault) was significantly higher with sirolimus versus CNI treatment (+3.0 vs. -1.4 mL/min/1.73 m(2) , respectively; p = 0.004).	Creatinine	81-91	CD59 molecule (CD59 blood group)	Homo sapiens	199-204
23076257-11	2012	Urine TGF-beta1 levels in patients with JC viruria, with BK viruria and without PyV viruria were 0.27 +- 0.09, 0.10 +- 0.05 and 0.13 +- 0.09 ng/mg of urine creatinine, respectively.	Creatinine	156-166	transforming growth factor beta 1	Homo sapiens	6-15
23102386-9	2012	RESULT: There was a positive non-parametric relation between serum Cr and cTnT (p = 0.028).	Creatinine	67-69	troponin T2, cardiac type	Homo sapiens	74-78
23102386-11	2012	CONCLUSION: In patients with CKD, serum Cr level has an impact on cTnT, but has no impact on cTnI and LVEF.	Creatinine	40-42	troponin T2, cardiac type	Homo sapiens	66-70
22241637-5	2012	RESULTS: We found that patients diagnosed with FSGS and with significant excretion of PDX-positive cells in the urine had a negative change in serum creatinine in the follow-up analysis.	Creatinine	149-159	podocalyxin like	Homo sapiens	86-89
22556030-10	2012	Total lung capacity &lt;80% predicted, MRSS, and serum creatinine were predictors of elevated CRP levels in SSc (odds ratio [OR] 2.76 [95% confidence interval (95% CI) 1.73-4.40], P = 0.0001; OR 1.03 [95% CI 1.01-1.05], P = 0.005; and OR 1.005 [95% CI 1.001-1.010], P = 0.02, respectively).	Creatinine	55-65	C-reactive protein	Homo sapiens	94-97
22241637-6	2012	In contrast to that, FSGS-patients without excretion of PDX-positive cells showed a positive change in serum creatinine.	Creatinine	109-119	podocalyxin like	Homo sapiens	56-59
22241637-7	2012	There was a significant negative correlation between PDX-positive cells in the urine and change in serum creatinine.	Creatinine	105-115	podocalyxin like	Homo sapiens	53-56
22985585-6	2012	CONCLUSION: The peripheral blood CD4(+)CD25(+)high/CD4(+) ratio and Foxp3 expression in the kidney recipients with CAN are significantly lower than those of recipients with normal renal graft function, which does not correlate with elevated creatinine level, suggesting a role of TREG in the occurrence and development of CAN.	Creatinine	241-251	CD4 molecule	Homo sapiens	33-36
22982912-5	2012	A significant correlation was found between the ACE mRNA gene expression and the mean blood pressure, serum creatinine, blood urea nitrogen and 24-h urinary protein.	Creatinine	108-118	angiotensin I converting enzyme	Homo sapiens	48-51
22527530-6	2012	To avoid dilution effects, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	110-120	interleukin 6	Homo sapiens	45-49
22527530-6	2012	To avoid dilution effects, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22898005-8	2012	Results from univariate logistic regression indicated that insulin resistance was significantly associated with male sex, greater waist circumference, higher triglyceride levels, lower high-density lipoprotein cholesterol levels, higher plasma creatinine levels, higher alanine transaminase levels, greater energy expenditure, and sleep duration of more than 8 hours per night.	Creatinine	244-254	insulin	Homo sapiens	59-66
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	42-45
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
21366514-7	2012	Ln (urinary AGT/Cr) showed a positive correlation with urinary protein/creatinine ratio (PCR) but a negative correlation with estimated glomerular filtration rate (eGFR).	Creatinine	71-81	angiotensinogen	Homo sapiens	12-15
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
22644350-5	2012	Changes in serum creatinine, although an important marker of renal function, may not be associated with adverse outcomes, especially if they are transient and a consequence of more aggressive decongestion, or the appropriate titration of drugs affecting the renin-angiotensin-aldosterone axis.	Creatinine	17-27	renin	Homo sapiens	258-263
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	angiotensinogen	Homo sapiens	70-73
22448714-8	2012	RESULTS: Pre-operative surface expression of CD99 and CD47 correlates with post-operative creatinine levels (P &lt; 0 05), a measurement of renal injury.	Creatinine	90-100	CD99 molecule (Xg blood group)	Homo sapiens	45-49
21993769-0	2012	Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients.	Creatinine	64-74	adiponectin, C1Q and collagen domain containing	Homo sapiens	11-22
22399491-4	2012	RESULTS: Compared to controls, median urinary angiotensinogen excretion (45.4 versus 7.4 mug/24 h, P &lt; 0.0001) and angiotensinogen-to-creatinine ratio (26.3 versus 4.4 mug/g, P &lt; 0.0001) were significantly higher in patients with CKD.	Creatinine	137-147	angiotensinogen	Homo sapiens	118-133
22902443-6	2012	Univariate logistic regression analysis revealed that the operative procedure, leukocyte count, and serum creatinine level at baseline were identified as factors that influence the continuity of S-1 chemotherapy.	Creatinine	106-116	proteasome 26S subunit, non-ATPase 1	Homo sapiens	195-198
22747708-5	2012	AKI and ACKI were defined by RIFLE criteria according to the increase of the index serum creatinine.	Creatinine	89-99	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	29-34
22926347-2	2012	Patients with endogenous creatinine clearance     30 mL/min/1.73m2 are introduced into the kidney transplant program.	Creatinine	25-35	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
22651225-11	2012	CONCLUSION: Age, arterial hypertension, tachycardia, and serum creatinine are independently associated with the level of hs-cTnT on admission for AECOPD.	Creatinine	63-73	troponin T2, cardiac type	Homo sapiens	124-128
22732335-10	2012	Serum creatinine levels correleted positively with both prolactin (r = 0.51, p &lt; 0.001) and macroprolactin levels (r = 0.43, p &lt; 0.001).	Creatinine	6-16	prolactin	Homo sapiens	56-65
23441532-13	2012	Comparison of eGFR as estimated by the compensated and uncompensated methods to determine creatinine concentration showed the same results as the comparison of clearance.	Creatinine	90-100	epidermal growth factor receptor	Homo sapiens	14-18
22441004-6	2012	The urinary sediment podocalyxin to creatinine ratio had a positive correlation with urinary albumin to creatinine ratio (r = 0.624; P&lt;.01) and urinary MCP-1 to creatinine ratio (r = 0.346; P&lt;.01).	Creatinine	36-46	podocalyxin like	Homo sapiens	21-32
22441004-6	2012	The urinary sediment podocalyxin to creatinine ratio had a positive correlation with urinary albumin to creatinine ratio (r = 0.624; P&lt;.01) and urinary MCP-1 to creatinine ratio (r = 0.346; P&lt;.01).	Creatinine	104-114	podocalyxin like	Homo sapiens	21-32
22441004-6	2012	The urinary sediment podocalyxin to creatinine ratio had a positive correlation with urinary albumin to creatinine ratio (r = 0.624; P&lt;.01) and urinary MCP-1 to creatinine ratio (r = 0.346; P&lt;.01).	Creatinine	104-114	podocalyxin like	Homo sapiens	21-32
22441720-7	2012	Furthermore, incident anemia at the end reached 7% in group TZD and 23% in group ACEI/ARB/TZD.Coadministration of RAS inhibitors and PPAR-gamma agonists should be considered in the differential diagnosis of hematocrit lowering and anemia in uncomplicated type 2 diabetic patients with normal serum creatinine.	Creatinine	298-308	peroxisome proliferator activated receptor gamma	Homo sapiens	133-143
22260463-5	2012	The rAAV-CYP2J2 gene delivery in vivo increased EET generation; attenuated the rise in blood pressure; and reduced the levels of proteinuria, serum creatinine, and blood urea nitrogen.	Creatinine	148-158	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	9-15
22050599-4	2012	Cox regression analysis in 5854 patients with detailed patient data prior to use of an insulin pump showed higher HbA(1c) (P&lt;0.0001), lower creatinine (P=0.002), high and low insulin doses (P&lt;0.0001), younger age (P&lt;0.0001) and female sex (P&lt;0.0001) to be associated with use of an insulin pump.	Creatinine	143-153	insulin	Homo sapiens	87-94
22050599-6	2012	A 10-mumol/l higher level of creatinine was associated with a hazard ratio of 0.56 (95% confidence interval 0.39-0.81) of starting use of an insulin pump.	Creatinine	29-39	insulin	Homo sapiens	141-148
22724391-5	2012	MEASUREMENTS: Estimated glomerular filtration rate (eGFR) was determined using the Chronic Kidney Disease Epidemiology Collaboration creatinine (eGFR(CR) ) and cystatin C one-variable (eGFR(CYS) ) equations.	Creatinine	133-143	epidermal growth factor receptor	Homo sapiens	52-56
23165574-10	2012	The following associations were found: gamma-glutamyl-transferase increased with soybean lipid intake and absolute diet; alkaline phosphatase increased with septic shock; alanine transaminase increased with septic shock, hyperglycemia and elevated creatinine; total bilirubin increased with septic shock, absolute diet, low prealbumin and glucose, and high creatinine.	Creatinine	248-258	glutathione hydrolase 3	Glycine max	39-65
22534204-3	2012	For every 1-unit increase in log-transformed well water arsenic (ln mug/L) and urinary arsenic (ln mug/g creatinine), plasma soluble VCAM-1 was 1.02 (95% confidence interval: 1.01, 1.03) and 1.04 (95% confidence interval: 1.01, 1.07) times greater, respectively.	Creatinine	105-115	vascular cell adhesion molecule 1	Homo sapiens	133-139
22357413-7	2012	The TGF-beta1 excretion was lower after tested therapies compared to the placebo (55.0 +- 7.56 vs. 56.21 +- 8.56 vs. 85.79 +- 14.11 pg/mg creatinine; P = 0.016); without differences between aliskiren and perindopril.	Creatinine	138-148	transforming growth factor beta 1	Homo sapiens	4-13
22452701-6	2012	In multiple regression analysis, soluble Klotho was associated with GH after correction for age, gender and levels of creatinine and phosphate (P = 0.029).	Creatinine	118-128	growth hormone 1	Homo sapiens	68-70
22856231-7	2012	UAE and serum creatinine significantly correlated with insulin resistance measured by eGDR (r=-0.13, and -0.17, all p&lt;0.05), and its components disorders, WHR and HbA1c.	Creatinine	14-24	insulin	Homo sapiens	55-62
22461538-11	2012	Patients with anti-P16 antibodies presented with higher serum creatinine on diagnosis (665.5+-227.2 versus 443.7+-296.8 mumol/L; P=0.001) and worse renal outcome during follow-up (hazard ratio, 2.10; 95% confidence interval, 1.10-3.90; P=0.02).	Creatinine	62-72	cyclin dependent kinase inhibitor 2A	Homo sapiens	19-22
21901638-5	2012	High PTX3 level was also associated with several other variables reflecting the severity of the disease: patients with high PTX3 level had higher maximum blood leukocyte (16.1 vs. 9.7 x 10(9)/l, p &lt; 0.001), plasma IL-6 (16.9 vs. 9.0 pg/ml, p = 0.007), and creatinine (282 vs. 124 mumol/l, p = 0.007) levels than patients with low maximum PTX3 level.	Creatinine	259-269	pentraxin 3	Homo sapiens	5-9
21901638-5	2012	High PTX3 level was also associated with several other variables reflecting the severity of the disease: patients with high PTX3 level had higher maximum blood leukocyte (16.1 vs. 9.7 x 10(9)/l, p &lt; 0.001), plasma IL-6 (16.9 vs. 9.0 pg/ml, p = 0.007), and creatinine (282 vs. 124 mumol/l, p = 0.007) levels than patients with low maximum PTX3 level.	Creatinine	259-269	pentraxin 3	Homo sapiens	124-128
21901638-5	2012	High PTX3 level was also associated with several other variables reflecting the severity of the disease: patients with high PTX3 level had higher maximum blood leukocyte (16.1 vs. 9.7 x 10(9)/l, p &lt; 0.001), plasma IL-6 (16.9 vs. 9.0 pg/ml, p = 0.007), and creatinine (282 vs. 124 mumol/l, p = 0.007) levels than patients with low maximum PTX3 level.	Creatinine	259-269	pentraxin 3	Homo sapiens	124-128
22421373-9	2012	From clamping on CO and PORT increased above baseline whereas REN (47%) with creatinine clearance remained compromised till the end.	Creatinine	77-87	renin	Sus scrofa	62-65
22278680-13	2012	Keratin7 expression provided additional discrimination potential to the age, bilirubin, international normalization ratio, creatinine (ABIC) score.	Creatinine	123-133	keratin 7	Homo sapiens	0-8
22822420-5	2012	RESULTS: At baseline, urinary angiotensinogen levels correlated with urinary albumin-creatinine ratio, urinary beta(2)-microglobulin and inversely with eGFR.	Creatinine	85-95	angiotensinogen	Homo sapiens	30-45
22856231-10	2012	Our results provide evidence of associations between insulin resistance and its components disorders with renal parameters, such as UAE and serum creatinine.	Creatinine	146-156	insulin	Homo sapiens	53-60
22360404-9	2012	In three patients with ARPKD, mean serum creatinine levels increased from 0.53 mg/dL at the time of LT to 0.91 mg/dL at the last follow-up (p = 0.01).	Creatinine	41-51	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	23-28
22345094-9	2012	CONCLUSIONS: This post-hoc analysis of the AVOID study suggests that renin inhibition with aliskiren 300 mg once daily added to losartan 100 mg once daily plus optimal antihypertensive therapy provides reductions in urinary albumin creatinine ratio that are efficacious in all, but particularly in poorly controlled, diabetic patients.	Creatinine	232-242	renin	Homo sapiens	69-74
22524236-1	2012	The effects of substituents on the temperature dependences of kinetic isotope effect (KIE) for the reactions of the hydride transfer from the substituted 5-methyl-6-phenyl-5,6-dihydrophenanthridine (G-PDH) to thioxanthylium (TX(+)) in acetonitrile were examined, and the results show that the temperature dependences of KIE for the hydride transfer reactions can be converted by adjusting the nature of the substituents in the molecule of the hydride donor.	Creatinine	116-123	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	201-204
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	epidermal growth factor receptor	Homo sapiens	163-167
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	prostaglandin D2 synthase	Homo sapiens	194-212
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	prostaglandin D2 synthase	Homo sapiens	214-217
21824169-9	2012	Moreover, the expression of alpha-SMA, fibronectin and MMP-9 mRNA correlated with serum creatinine levels (r = 0 514, r = 0 53 and r = 0 469, all P &lt; 0 001) and GFR levels (r = -0 374, r = -0 392 and r = -0 487, all P &lt; 0 01).	Creatinine	88-98	fibronectin 1	Homo sapiens	39-50
22293928-7	2012	Serum FGF21 levels showed a positive correlation with the urine albumin-to-creatinine ratio (ACR) in all subjects except for the T2DM subjects, who showed a correlation after adjustment of age, gender and body mass index.	Creatinine	75-85	fibroblast growth factor 21	Homo sapiens	6-11
22183771-4	2012	RESULTS: A donor source-adjusted linear mixed model with multilevel analysis adjusting for age, body weight, hematocrit, and serum creatinine showed that CYP3A5 genotype is associated with dose-adjusted level of tacrolimus (p &lt; 0.001).	Creatinine	131-141	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	154-160
22388796-8	2012	Mixed-model analysis demonstrated that the overall creatinine clearance was 20% lower in CYP3A4*22 allele carriers compared with CYP3A4*1/*1 patients [CI(95%) (-33.1 to -7.2%), P=0.002].	Creatinine	51-61	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	89-95
22388796-10	2012	CONCLUSION: CYP3A4*22 constitutes a risk factor for DGF and worse creatinine clearance in patients receiving CsA-based immunosuppressive therapy.	Creatinine	66-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	12-18
22198016-11	2012	In rats with CKD, ACE inhibition had major benefits to reduce blood pressure and cardiac hypertrophy and to improve creatinine clearance, but did not significantly impact on cardiac ACE2, cardiac interstitial fibrosis, renal fibrosis or proteinuria.	Creatinine	116-126	angiotensin I converting enzyme	Rattus norvegicus	18-21
21992860-7	2012	RESULTS: Serum adiponectin was significantly elevated in complicated diabetes (10.3 +- 5.9 pg/dL) as compared to the controls (6.5 +- 3.7 pg/dL) (P&lt;0.01), and correlated directly with HbA1c (P&lt;0.05) and creatinine (P&lt;0.001).	Creatinine	209-219	adiponectin, C1Q and collagen domain containing	Homo sapiens	15-26
22460095-3	2012	MATERIAL/METHODS: We analyzed expression of ASMA in percutaneous renal biopsy of 142 adult and pediatric patients with GN and its correlation with blood pressure, serum creatinine, creatinine clearance and 24-hour urine protein at the time of biopsy.	Creatinine	169-179	actin alpha 1, skeletal muscle	Homo sapiens	44-48
22460095-3	2012	MATERIAL/METHODS: We analyzed expression of ASMA in percutaneous renal biopsy of 142 adult and pediatric patients with GN and its correlation with blood pressure, serum creatinine, creatinine clearance and 24-hour urine protein at the time of biopsy.	Creatinine	181-191	actin alpha 1, skeletal muscle	Homo sapiens	44-48
22460095-6	2012	RESULTS: In adults and children, greater expression of ASMA in interstitium was associated with higher serum creatinine and reduced creatinine clearance.	Creatinine	109-119	actin alpha 1, skeletal muscle	Homo sapiens	55-59
22460095-6	2012	RESULTS: In adults and children, greater expression of ASMA in interstitium was associated with higher serum creatinine and reduced creatinine clearance.	Creatinine	132-142	actin alpha 1, skeletal muscle	Homo sapiens	55-59
22460095-7	2012	Conversely, greater ASMA expression in glomeruli was associated with normal or decreased serum creatinine in adults and increased creatinine clearance in children.	Creatinine	95-105	actin alpha 1, skeletal muscle	Homo sapiens	20-24
22460095-7	2012	Conversely, greater ASMA expression in glomeruli was associated with normal or decreased serum creatinine in adults and increased creatinine clearance in children.	Creatinine	130-140	actin alpha 1, skeletal muscle	Homo sapiens	20-24
22460095-10	2012	The connection of ASMA expression in glomeruli with lower serum creatinine and normal or increased creatinine clearance suggests a favorable role of this phenotypic change in glomerular filtration rate; further investigation is needed.	Creatinine	64-74	actin alpha 1, skeletal muscle	Homo sapiens	18-22
22460095-10	2012	The connection of ASMA expression in glomeruli with lower serum creatinine and normal or increased creatinine clearance suggests a favorable role of this phenotypic change in glomerular filtration rate; further investigation is needed.	Creatinine	99-109	actin alpha 1, skeletal muscle	Homo sapiens	18-22
22541095-8	2012	There was a positive correlation between IL-17 and serum calcium beta2-microglobulin or C-reactive protein (P &lt; 0.01), and there was also a positive correlation between VEGF and serum creatinine serum Bene-Jones protein lambda or urinary Bene-Jones protein lambda (P &lt; 0.01).	Creatinine	187-197	vascular endothelial growth factor A	Homo sapiens	172-176
22160777-6	2012	In contrast, renal injury and elevation of creatinine were significantly ameliorated in mice subjected to IRI and receiving ITF 1697.	Creatinine	43-53	trefoil factor 3, intestinal	Mus musculus	124-127
22870359-6	2012	The renal safety was evaluated by changes of blood urea nitrogen (BUN), creatinine and urine N-acetyl-b-glucoseaminidase (NAG)-creatinine ratio at 24 hours and 72 hours after surgery from preoperative level.	Creatinine	127-137	N-acetyl-alpha-glucosaminidase	Homo sapiens	122-125
22870359-8	2012	However, the BUN and urine NAG-creatinine ratios at 72 hours after surgery were higher in isoflurane anesthesia in some carbon dioxide absorbent groups (P = 0.03 and 0.04, respectively).	Creatinine	31-41	N-acetyl-alpha-glucosaminidase	Homo sapiens	27-30
22205541-9	2012	CART analysis identified four variables for prediction of SBP: creatinine, total bilirubin, prothrombin time and white blood cell count, and three risk groups: low (2.0%), intermediate (27.5-33.3%) and high (60.6-86.4%) risk.	Creatinine	63-73	CART prepropeptide	Homo sapiens	0-4
22133274-8	2012	Polymorphisms of GP VI and VWF associated with lower creatinine levels during PUUV infection.	Creatinine	53-63	von Willebrand factor	Homo sapiens	27-30
22258025-4	2012	The eGFR values were determined using the following equation: eGFR=194 x (serum creatinine)(-1.094) x (age)(-0.287) ( x 0.739 if female).	Creatinine	80-90	epidermal growth factor receptor	Homo sapiens	4-8
22258025-4	2012	The eGFR values were determined using the following equation: eGFR=194 x (serum creatinine)(-1.094) x (age)(-0.287) ( x 0.739 if female).	Creatinine	80-90	epidermal growth factor receptor	Homo sapiens	62-66
22337915-7	2012	When participants were divided into two subgroups based on mean PTH and OC levels, the group of T2DM women with lower PTH and lower OC levels had a significantly higher risk of VF than those with higher PTH and higher OC levels after adjusting for age, body mass index, hemoglobin A(1c), creatinine, 25-hydroxyvitamin D, and lumbar bone mineral density (odds ratio, 4.73; 95% confidence interval, 1.20-18.6; P = 0.026).	Creatinine	288-298	parathyroid hormone	Homo sapiens	118-121
22337915-7	2012	When participants were divided into two subgroups based on mean PTH and OC levels, the group of T2DM women with lower PTH and lower OC levels had a significantly higher risk of VF than those with higher PTH and higher OC levels after adjusting for age, body mass index, hemoglobin A(1c), creatinine, 25-hydroxyvitamin D, and lumbar bone mineral density (odds ratio, 4.73; 95% confidence interval, 1.20-18.6; P = 0.026).	Creatinine	288-298	bone gamma-carboxyglutamate protein	Homo sapiens	132-134
22337915-7	2012	When participants were divided into two subgroups based on mean PTH and OC levels, the group of T2DM women with lower PTH and lower OC levels had a significantly higher risk of VF than those with higher PTH and higher OC levels after adjusting for age, body mass index, hemoglobin A(1c), creatinine, 25-hydroxyvitamin D, and lumbar bone mineral density (odds ratio, 4.73; 95% confidence interval, 1.20-18.6; P = 0.026).	Creatinine	288-298	parathyroid hormone	Homo sapiens	118-121
22337915-7	2012	When participants were divided into two subgroups based on mean PTH and OC levels, the group of T2DM women with lower PTH and lower OC levels had a significantly higher risk of VF than those with higher PTH and higher OC levels after adjusting for age, body mass index, hemoglobin A(1c), creatinine, 25-hydroxyvitamin D, and lumbar bone mineral density (odds ratio, 4.73; 95% confidence interval, 1.20-18.6; P = 0.026).	Creatinine	288-298	bone gamma-carboxyglutamate protein	Homo sapiens	132-134
21839494-10	2012	In contrast, renal function correlated inversely with von Willebrand factor levels (r(creatinine)=0.48, p&lt;0.0001; r(eGFR)=-0.46, p&lt;0.001; r(cystatin C)=0.54, p&lt;0.0001).	Creatinine	86-96	von Willebrand factor	Homo sapiens	54-75
22483466-13	2012	Multivariate analysis revealed that gender, body weight, serum creatinine, triglyceride, and HDL cholesterol were associated with APN level.	Creatinine	63-73	adiponectin, C1Q and collagen domain containing	Homo sapiens	130-133
22781716-8	2012	The ratio of Notch1 on the membrane of CD38(+)CD138(+) plasma cells of MM patients who had renal dysfunction was correlated to their abnormal serum creatinine levels.	Creatinine	148-158	notch receptor 1	Homo sapiens	13-19
22252480-4	2012	RESULTS: In a sex, BMI, smoking habit, physical activity level and serum creatinine adjusted model, low-density lipoprotein-cholesterol (LDL-C) appears to be significantly related to SBP (P &lt; 0.001), DBP (P = 0.026), and pulse pressure (PP) (P &lt; 0.001).	Creatinine	73-83	component of oligomeric golgi complex 2	Homo sapiens	100-135
22252480-4	2012	RESULTS: In a sex, BMI, smoking habit, physical activity level and serum creatinine adjusted model, low-density lipoprotein-cholesterol (LDL-C) appears to be significantly related to SBP (P &lt; 0.001), DBP (P = 0.026), and pulse pressure (PP) (P &lt; 0.001).	Creatinine	73-83	component of oligomeric golgi complex 2	Homo sapiens	137-142
21725924-8	2012	Statistical analysis revealed positive correlations between Snai1/vimentin double positive cell numbers and proteinuria and creatinine in IgAN.	Creatinine	124-134	snail family transcriptional repressor 1	Homo sapiens	60-65
22868812-5	2012	Patients with ROMs levels &gt;=273 CARR U were significantly older, had higher C-reactive protein levels and lower creatinine concentrations.	Creatinine	115-125	arrestin 3	Homo sapiens	35-39
22128916-8	2012	Although both WT HFF and IL-6-/- HFF mice exhibited renal impairment as measured by increased serum creatinine and urinary albumin/creatinine ratios, this was exacerbated in IL-6-/- mice.	Creatinine	100-110	interleukin 6	Mus musculus	25-29
22128916-8	2012	Although both WT HFF and IL-6-/- HFF mice exhibited renal impairment as measured by increased serum creatinine and urinary albumin/creatinine ratios, this was exacerbated in IL-6-/- mice.	Creatinine	131-141	interleukin 6	Mus musculus	25-29
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	227-237	interleukin 1 beta	Homo sapiens	112-129
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	227-237	interleukin 1 beta	Homo sapiens	130-138
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	297-307	interleukin 1 beta	Homo sapiens	112-129
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	297-307	interleukin 1 beta	Homo sapiens	130-138
22268645-7	2012	Results showed that mean urinary levels of 5-meC and 5-medC were 28.4 +- 14.3 and 7.04 +- 7.2 ng/mg creatinine, respectively, supporting the possible presence of DNA demethylation through BER and NER mechanisms.	Creatinine	100-110	C-C motif chemokine ligand 28	Homo sapiens	45-48
21924736-3	2012	Serum 25(OH)D was correlated with urinary vitamin D binding protein/creatinine ratio (DBP/C) and other indicators of proteinuria.	Creatinine	68-78	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
22052073-10	2012	Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P &lt; 0.0001), and with IL-6 (P &lt; 0.05).	Creatinine	20-30	tumor necrosis factor	Homo sapiens	47-56
22052073-10	2012	Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P &lt; 0.0001), and with IL-6 (P &lt; 0.05).	Creatinine	20-30	interleukin 6	Homo sapiens	101-105
22052073-11	2012	A multivariate linear regression analysis showed that gender, smoking, and TNF-alpha were independent factors of 8-OHdG/creatinine.	Creatinine	120-130	tumor necrosis factor	Homo sapiens	75-84
22113073-9	2012	RESULTS: After adjustment for age, body mass index, waist:hip ratio, smoking, hypertension, dyslipidemia, diabetes, coronary heart disease and serum creatinine, a higher IGF1 level was associated with AAA (odds ratio (OR)/1 s.d.	Creatinine	149-159	insulin like growth factor 1	Homo sapiens	170-174
22012129-7	2012	Finally, specific siRNA-induced knockdown of calpain 10 in the proximal tubules of control rats resulted in decreased renal function as evidenced by increased serum creatinine, and increased caspase 3 cleavage compared with rats receiving scrambled siRNA.	Creatinine	165-175	calpain 10	Rattus norvegicus	45-55
22213707-6	2012	The limits of detection were 7.9 nM for serotonin and 13.3 muM for creatinine, respectively.	Creatinine	67-77	latexin	Homo sapiens	59-62
22152800-5	2012	Through the sol-gel process, a polymeric matrix with memory sites for Cre was obtained, and this is mentioned here as the molecularly imprinted polymer for creatinine (MIP(Cre)).	Creatinine	156-166	major intrinsic protein of lens fiber	Homo sapiens	168-176
21933002-9	2012	Adiponectin was correlated negatively with CIMT (r=-0.24, P=0.03), age (r=-0.30, P=0.02), BMI (r=-0.33, P=0.02), waist-to-hip ratio (WHR) (r=-0.38, P=0.01) and positively with creatinine (r=0.44, P=0.004).	Creatinine	176-186	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
21933002-12	2012	Multivariate analysis revealed resistin and creatinine to be independent predictors of CIMT among adiponectin, leptin, resistin, WHR, glycosylated hemoglobin (HbA1c), and creatinine.	Creatinine	44-54	adiponectin, C1Q and collagen domain containing	Homo sapiens	98-109
22146314-10	2012	Mean estimated creatinine clearance 1 year posttransplant was 93.2+-33.3 mL/min/1.73 m(2).	Creatinine	15-25	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
22248584-6	2012	Twist protein in the tubulointerstitium was inversely correlated with estimated glomerular filtration rate (eGFR; r = -0.468, p = 0.029) and positively correlated with serum creatinine (r = 0.44, p = 0.045) and the percentage of tubulointerstitial fibrosis (r = 0.551, p = 0.000).	Creatinine	174-184	twist family bHLH transcription factor 1	Homo sapiens	0-5
22000727-7	2012	Kidney function was assessed by eGFR based on serum creatinine (eGFR(SCr)) and cystatin C (eGFR(SCysC)).	Creatinine	52-62	epidermal growth factor receptor	Homo sapiens	32-36
22320202-4	2012	Logarithmic transformations of urinary AGT-creatinine ratio log(UAGT/Ucre) and urinary protein-to-creatinine ratio (UPCR) were done to obtain the normal distributions of these parameters.	Creatinine	43-53	angiotensinogen	Homo sapiens	39-42
21896346-9	2012	When neither the donor nor the recipient had the CC genotype of MDR1 +1236, patients had lower creatinine levels (P &lt; .001) and less transplantation-related mortality (TRM) (P = .012).	Creatinine	95-105	ATP binding cassette subfamily B member 1	Homo sapiens	64-68
23113413-4	2012	Concentrations of IL-1beta, IL-6 and IL-8 related to creatinine levels (pg/micromol) were determined in urine samples in all.	Creatinine	53-63	interleukin 1 beta	Homo sapiens	18-26
22699456-8	2012	At specific GFR estimates, serum Cr remained a significant predictor of NSAID/COX-2 prescription.	Creatinine	33-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
23091554-7	2012	The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 (P = 0.011) positive patients than that in the negative patients.	Creatinine	32-42	major histocompatibility complex, class II, DR beta 1	Homo sapiens	66-70
23091554-7	2012	The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 (P = 0.011) positive patients than that in the negative patients.	Creatinine	32-42	major histocompatibility complex, class II, DR beta 1	Homo sapiens	96-100
23097674-3	2012	There was a rapid increase of the serum VEGF level in all patients from the fever onset to oliguric stage, at which the serum creatinine reached the peak level of the disease, indicating that VEGF may be involved in the pathogenesis of renal hyper-permeability.	Creatinine	126-136	vascular endothelial growth factor A	Homo sapiens	40-44
23097674-3	2012	There was a rapid increase of the serum VEGF level in all patients from the fever onset to oliguric stage, at which the serum creatinine reached the peak level of the disease, indicating that VEGF may be involved in the pathogenesis of renal hyper-permeability.	Creatinine	126-136	vascular endothelial growth factor A	Homo sapiens	192-196
22331976-10	2012	There was a significant correlation between VEGF and albumin to creatinine ratio (P = 0.017, r = 0.432).	Creatinine	64-74	vascular endothelial growth factor A	Homo sapiens	44-48
21883437-0	2012	Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes.	Creatinine	48-58	insulin	Homo sapiens	38-47
21883437-2	2012	Urine C-peptide creatinine ratio is a non-invasive alternative that is stable for at least 3 days at room temperature in boric acid preservative.	Creatinine	16-26	insulin	Homo sapiens	6-15
21883437-3	2012	We aimed to assess the utility of urine C-peptide creatinine ratio in individuals with Type 2 diabetes as an alternative to serum C-peptide.	Creatinine	50-60	insulin	Homo sapiens	40-49
23113413-4	2012	Concentrations of IL-1beta, IL-6 and IL-8 related to creatinine levels (pg/micromol) were determined in urine samples in all.	Creatinine	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23113413-8	2012	However, IL-8/creatinine levels were almost significant higher in case group (median 3.5 pg/micromol; SD 9.2) than in control group (median 1.54 pg/micromol; SD 3) (P=0.001).	Creatinine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
23113413-10	2012	CONCLUSIONS: Urinary levels of IL-8/creatinine are elevated in children with vesicoureteral reflux, even in absence of urinary tract infection.	Creatinine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22710867-7	2012	There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041).	Creatinine	62-72	microRNA 192	Homo sapiens	120-127
22710867-7	2012	There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041).	Creatinine	189-199	microRNA 192	Homo sapiens	234-241
21717198-7	2011	The FDA recently approved the 150-mg bid dose for patients with a creatinine clearance above 30 mL/min and 75 mg bid for use in patients with a creatinine clearance of 15 to 30 mL/min.	Creatinine	66-76	BH3 interacting domain death agonist	Homo sapiens	37-40
21883437-5	2012	RESULTS: Urine C-peptide creatinine ratio was at least as reproducible as serum C-peptide [fasting coefficient of variation mean (95% CI): 28 (21-35)% vs. 38 (26-59)% and 2-h post-meal 26 (18-33)% vs. 27 (20-34)%.	Creatinine	25-35	insulin	Homo sapiens	15-24
21883437-6	2012	Urine C-peptide creatinine ratio 2 h post-meal was correlated with stimulated serum C-peptide, both the 2-h value (r = 0.64, P &lt; 0.001) and the 2-h area under the C-peptide curve (r = 0.63, P &lt; 0.001).	Creatinine	16-26	insulin	Homo sapiens	6-15
21883437-6	2012	Urine C-peptide creatinine ratio 2 h post-meal was correlated with stimulated serum C-peptide, both the 2-h value (r = 0.64, P &lt; 0.001) and the 2-h area under the C-peptide curve (r = 0.63, P &lt; 0.001).	Creatinine	16-26	insulin	Homo sapiens	84-93
21883437-6	2012	Urine C-peptide creatinine ratio 2 h post-meal was correlated with stimulated serum C-peptide, both the 2-h value (r = 0.64, P &lt; 0.001) and the 2-h area under the C-peptide curve (r = 0.63, P &lt; 0.001).	Creatinine	16-26	insulin	Homo sapiens	84-93
21883437-8	2012	CONCLUSIONS: In patients with Type 2 diabetes, a single urine C-peptide creatinine ratio is a stable, reproducible measure that is well correlated with serum C-peptide following meal stimulation, even if there is moderate renal impairment.	Creatinine	72-82	insulin	Homo sapiens	62-71
21883437-8	2012	CONCLUSIONS: In patients with Type 2 diabetes, a single urine C-peptide creatinine ratio is a stable, reproducible measure that is well correlated with serum C-peptide following meal stimulation, even if there is moderate renal impairment.	Creatinine	72-82	insulin	Homo sapiens	158-167
21883437-9	2012	Urine C-peptide creatinine ratio therefore has potential for use in clinical practice in the assessment of Type 2 diabetes.	Creatinine	16-26	insulin	Homo sapiens	6-15
21976404-11	2012	Significant positive correlations were found between serum ACE level and serum creatinine and 24 h proteinuria (p = 0.03, 0.009, respectively).	Creatinine	79-89	angiotensin I converting enzyme	Homo sapiens	59-62
23307163-5	2012	RESULTS: A significant attenuation of the augmented responses to angiotensin II was observed in CoCl(2)-treated animals along with a fall in plasma urea, creatinine and uric acid levels.	Creatinine	154-164	angiotensinogen	Rattus norvegicus	65-79
22368756-6	2012	The correlation of urine albumin - creatinine ratio with CD4 count, duration of treatment with highly active antiretroviral therapy (HAART) and association with clinical staging of the disease was also examined.	Creatinine	35-45	CD4 molecule	Homo sapiens	57-60
22368756-9	2012	There was a significant correlation between CD4 count and urine albumin - creatinine ratio (r=-0.22, p=0.03).	Creatinine	74-84	CD4 molecule	Homo sapiens	44-47
23285077-7	2012	Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p&lt;=0.003), but not in non-diabetics (all p&gt;=0.16), with significant interactions by diabetes status (interaction-p&lt;=0.009).	Creatinine	63-73	epidermal growth factor receptor	Homo sapiens	79-83
21923802-8	2012	Urinary AGT-creatinine ratio (UAGT/UCre) was significantly higher in hypertensive patients compared with the normotensives (8.98 +- 6.89 mug/g vs. 5.48 +- 3.33 mug/g; P = 0.037).	Creatinine	12-22	angiotensinogen	Homo sapiens	8-11
25653747-8	2012	Creatinine and SPtn, MUN and MPtn were the main parameters in that the relationships between MPtn with BUN, SPtn and creatinine were more noticeable than others.	Creatinine	0-10	casein beta	Bos taurus	93-97
25653747-8	2012	Creatinine and SPtn, MUN and MPtn were the main parameters in that the relationships between MPtn with BUN, SPtn and creatinine were more noticeable than others.	Creatinine	117-127	casein beta	Bos taurus	93-97
21717198-7	2011	The FDA recently approved the 150-mg bid dose for patients with a creatinine clearance above 30 mL/min and 75 mg bid for use in patients with a creatinine clearance of 15 to 30 mL/min.	Creatinine	144-154	BH3 interacting domain death agonist	Homo sapiens	113-116
22200710-6	2011	In IF/TA group, the expression of TIMP-1 was positively correlated to serum creatinine level (r=0.718, P=0.00&lt;0.05).	Creatinine	76-86	TIMP metallopeptidase inhibitor 1	Homo sapiens	34-40
21439949-2	2011	The objective of this study is to scan a positional candidate gene, Transient Receptor Potential cation channel, subfamily M 1 (TRPM1), for genetic variants that may contribute to the variation in albumin-to-creatinine ratio (ACR).	Creatinine	208-218	transient receptor potential cation channel subfamily M member 1	Homo sapiens	128-133
22085404-10	2011	Disease severity characterized by elevated creatinine and low platelet counts was correlated with high pro-inflammatory IL-6 and TNF-alpha but low immunosuppressive TGF-beta1 levels and vice versa .	Creatinine	43-53	interleukin 6	Homo sapiens	120-124
22085404-10	2011	Disease severity characterized by elevated creatinine and low platelet counts was correlated with high pro-inflammatory IL-6 and TNF-alpha but low immunosuppressive TGF-beta1 levels and vice versa .	Creatinine	43-53	tumor necrosis factor	Homo sapiens	129-138
22085404-10	2011	Disease severity characterized by elevated creatinine and low platelet counts was correlated with high pro-inflammatory IL-6 and TNF-alpha but low immunosuppressive TGF-beta1 levels and vice versa .	Creatinine	43-53	transforming growth factor beta 1	Homo sapiens	165-174
21816756-12	2011	Npt2b(+/+) mice with adenine-induced renal failure had hyperphosphatemia and high plasma creatinine levels.	Creatinine	89-99	solute carrier family 34 (sodium phosphate), member 2	Mus musculus	0-5
21997818-12	2011	Peak AST, H-FABP, and NGAL correlated with peak creatinine [Pearson coefficients: 0.70 (P = 0.001), 0.85 (P &lt; 0.0001), 0.80 (P &lt; 0.0001)].	Creatinine	48-58	solute carrier family 17 member 5	Homo sapiens	5-8
21997818-12	2011	Peak AST, H-FABP, and NGAL correlated with peak creatinine [Pearson coefficients: 0.70 (P = 0.001), 0.85 (P &lt; 0.0001), 0.80 (P &lt; 0.0001)].	Creatinine	48-58	fatty acid binding protein 3	Homo sapiens	10-16
25984195-0	2011	Age- and gender-adjusted eGFR to estimate baseline creatinine for RIFLE criteria.	Creatinine	51-61	epidermal growth factor receptor	Homo sapiens	25-29
21919965-7	2011	Serum creatinine after three months was 166 muM in HBD and 213 muM in DCD (p &lt; 0.001).	Creatinine	6-16	latexin	Homo sapiens	44-47
21919965-7	2011	Serum creatinine after three months was 166 muM in HBD and 213 muM in DCD (p &lt; 0.001).	Creatinine	6-16	latexin	Homo sapiens	63-66
21949094-8	2011	Mice deficient in the CXCL1 receptor also had lower serum creatinine, ATN, and apoptosis than wildtype mice following cisplatin-induced AKI.	Creatinine	58-68	chemokine (C-X-C motif) ligand 1	Mus musculus	22-27
21511816-7	2011	Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death.	Creatinine	183-193	interleukin 6	Homo sapiens	49-53
22099812-9	2011	Mean creatinine clearance at 1 year was 65 versus 50 mL/min/1.73 m(2) (P = .5) and at 5 years, 60 versus 55 mL/min/1.73 m(2) (P = .1) for the single versus multiple renal arteries groups, respectively.	Creatinine	5-15	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
21839662-6	2011	In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (beta=-0.12, p=0.036 and beta=-0.22, p&lt;0.001, respectively).	Creatinine	87-97	insulin like growth factor 1	Homo sapiens	136-141
21691251-8	2011	The uNGAL/urinary creatinine (uCreat) ratio at birth was higher in the IRF group (31.05 ng/mg) than the NRF group (6.0 ng/mg), and uNGAL was significantly higher in IRF group, detecting IRF with a cutoff of 100 ng/mL.	Creatinine	18-28	tripartite motif containing 63	Homo sapiens	71-74
21489578-10	2011	Multivariate logistic regression analysis demonstrated that independently associated with the reduction in albumin to creatinine ratio (84.8 vs 28.7 mug/mg creatinine) were amelioration of glycemic control (P &lt; .001), blood pressure (P = .02), dyslipidemia (P = .02), and insulin resistance (P = .05).	Creatinine	118-128	insulin	Homo sapiens	275-282
22276466-1	2011	UNLABELLED: The objective of this study was to evaluate the association of traditional cardiovascular risk factors, adipokines, inflammation and insulin resistance with low-grade urinary albumin-to-creatinine ratio (ACR) in nondiabetic, healthy subjects.	Creatinine	198-208	insulin	Homo sapiens	145-152
20711842-10	2011	RIFLE criteria were accurate predictors of outcome, though they missed much of the risk of even smaller increases in creatinine.	Creatinine	117-127	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	0-5
21996226-9	2011	Upon univariate analysis, urinary L-FABP correlated, with serum creatinine, cystatin C and estimated glomerular filtration ratio (eGFR) in kidney allograft recipients.	Creatinine	64-74	fatty acid binding protein 1	Homo sapiens	34-40
21791552-6	2011	Regression analysis revealed that CD34+, CD34+/KDR+ and CD34+/CD45- hematopoietic CPCs were associated positively with eGFR and negatively with blood urea nitrogen and serum creatinine.	Creatinine	174-184	CD34 molecule	Homo sapiens	34-38
21843301-0	2011	Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes.	Creatinine	16-26	insulin	Homo sapiens	6-15
21843301-2	2011	Urine C-peptide creatinine ratio may be a non-invasive practical alternative.	Creatinine	16-26	insulin	Homo sapiens	6-15
21843301-4	2011	We aimed to assess how urine C-peptide creatinine ratio compared with serum C-peptide measurement during a mixed-meal tolerance test in individuals with late-onset, insulin-treated diabetes.	Creatinine	39-49	insulin	Homo sapiens	29-38
21843301-5	2011	METHODS: We correlated the gold standard of a stimulated serum C-peptide in a mixed-meal tolerance test with fasting and stimulated (mixed-meal tolerance test, standard home meal and largest home meal) urine C-peptide creatinine ratio in 51 subjects with insulin-treated diabetes (diagnosis after age 30 years, median age 66 years, median age at diagnosis 54, 42 with Type 2 diabetes, estimated glomerular filtration rate &gt; 60 ml min(-1) 1.73 m(-2) ).	Creatinine	218-228	insulin	Homo sapiens	208-217
21843301-6	2011	RESULTS: Ninety-minute mixed-meal tolerance test serum C-peptide is correlated with mixed-meal tolerance test-stimulated urine C-peptide creatinine ratio (r = 0.82), urine C-peptide creatinine ratio after a standard breakfast at home (r = 0.73) and urine C-peptide creatinine ratio after largest home meal (r = 0.71).	Creatinine	137-147	insulin	Homo sapiens	55-64
21843301-6	2011	RESULTS: Ninety-minute mixed-meal tolerance test serum C-peptide is correlated with mixed-meal tolerance test-stimulated urine C-peptide creatinine ratio (r = 0.82), urine C-peptide creatinine ratio after a standard breakfast at home (r = 0.73) and urine C-peptide creatinine ratio after largest home meal (r = 0.71).	Creatinine	182-192	insulin	Homo sapiens	55-64
21843301-6	2011	RESULTS: Ninety-minute mixed-meal tolerance test serum C-peptide is correlated with mixed-meal tolerance test-stimulated urine C-peptide creatinine ratio (r = 0.82), urine C-peptide creatinine ratio after a standard breakfast at home (r = 0.73) and urine C-peptide creatinine ratio after largest home meal (r = 0.71).	Creatinine	182-192	insulin	Homo sapiens	55-64
21843301-7	2011	A stimulated (largest home meal) urine C-peptide creatinine ratio cut-off of 0.3 nmol/mmol had a 100% sensitivity and 96% specificity (area under receiver operating characteristic curve = 0.99) in identifying subjects without clinically significant endogenous insulin secretion (mixed-meal tolerance test-stimulated C-peptide &lt; 0.2 nmol/l).	Creatinine	49-59	insulin	Homo sapiens	39-48
21843301-9	2011	CONCLUSION: In patients with insulin-treated diabetes diagnosed after age 30 years, urine C-peptide creatinine ratio is well correlated with serum C-peptide and may provide a practical alternative measure to detect insulin deficiency for use in routine clinical practice.	Creatinine	100-110	insulin	Homo sapiens	90-99
21843301-9	2011	CONCLUSION: In patients with insulin-treated diabetes diagnosed after age 30 years, urine C-peptide creatinine ratio is well correlated with serum C-peptide and may provide a practical alternative measure to detect insulin deficiency for use in routine clinical practice.	Creatinine	100-110	insulin	Homo sapiens	147-156
21791552-6	2011	Regression analysis revealed that CD34+, CD34+/KDR+ and CD34+/CD45- hematopoietic CPCs were associated positively with eGFR and negatively with blood urea nitrogen and serum creatinine.	Creatinine	174-184	CD34 molecule	Homo sapiens	41-45
21670416-6	2011	The urinary angiotensinogen:creatinine ratio was significantly higher in patients who consumed the ordinary salt diet compared with the low-salt diet (17.5 mug/g [range: 7.3 to 35.6 mug/g] versus 7.9 mug/g [range: 3.1 to 14.2 mug/g] of creatinine, respectively; P&lt;0.001).	Creatinine	28-38	angiotensinogen	Homo sapiens	12-27
21791552-6	2011	Regression analysis revealed that CD34+, CD34+/KDR+ and CD34+/CD45- hematopoietic CPCs were associated positively with eGFR and negatively with blood urea nitrogen and serum creatinine.	Creatinine	174-184	CD34 molecule	Homo sapiens	41-45
21864386-14	2011	At all time points, s-TATI correlated with higher age (P &lt; 0.001-0.021) and with increased s-creatinine concentrations assessed prior to surgery (P = 0.041).	Creatinine	96-106	serine peptidase inhibitor Kazal type 1	Homo sapiens	22-26
21545814-10	2011	Single regression analyses performed in all specified groups revealed significant associations between adiponectin and estimated creatinine clearance, however a multiple regression model revealed that insulin resistance had the strongest association with adiponectin within all the groups.	Creatinine	129-139	adiponectin, C1Q and collagen domain containing	Homo sapiens	103-114
21945876-0	2011	C-reactive protein is directly associated with urinary albumin-to-creatinine ratio.	Creatinine	66-76	C-reactive protein	Homo sapiens	0-18
21945876-2	2011	We undertook this study to evaluate whether elevated C-reactive protein (CRP) levels are independently associated with urinary albumin-to-creatinine ratio (UACR) in the offspring of subjects with diabetic nephropathy.	Creatinine	138-148	C-reactive protein	Homo sapiens	53-71
21945876-2	2011	We undertook this study to evaluate whether elevated C-reactive protein (CRP) levels are independently associated with urinary albumin-to-creatinine ratio (UACR) in the offspring of subjects with diabetic nephropathy.	Creatinine	138-148	C-reactive protein	Homo sapiens	73-76
21670416-6	2011	The urinary angiotensinogen:creatinine ratio was significantly higher in patients who consumed the ordinary salt diet compared with the low-salt diet (17.5 mug/g [range: 7.3 to 35.6 mug/g] versus 7.9 mug/g [range: 3.1 to 14.2 mug/g] of creatinine, respectively; P&lt;0.001).	Creatinine	236-246	angiotensinogen	Homo sapiens	12-27
21501169-9	2011	In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (beta=-0.45, p&lt;0.0001).	Creatinine	77-87	bone gamma-carboxyglutamate protein	Homo sapiens	61-72
21382126-7	2011	RESULTS: Mean urinary TGF-beta1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +- 0.67 creatinine vs 1.80 +- 0.24 pg/mmol creatinine, P &lt; 0.05) and healthy controls (1.66 +- 0.28 pg/mmol creatinine, P &lt; 0.05).	Creatinine	127-137	transforming growth factor beta 1	Homo sapiens	22-31
21382126-7	2011	RESULTS: Mean urinary TGF-beta1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +- 0.67 creatinine vs 1.80 +- 0.24 pg/mmol creatinine, P &lt; 0.05) and healthy controls (1.66 +- 0.28 pg/mmol creatinine, P &lt; 0.05).	Creatinine	162-172	transforming growth factor beta 1	Homo sapiens	22-31
21382126-7	2011	RESULTS: Mean urinary TGF-beta1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +- 0.67 creatinine vs 1.80 +- 0.24 pg/mmol creatinine, P &lt; 0.05) and healthy controls (1.66 +- 0.28 pg/mmol creatinine, P &lt; 0.05).	Creatinine	162-172	transforming growth factor beta 1	Homo sapiens	22-31
21616953-5	2011	In univariate analysis, plasma copeptin showed a moderate but significant correlation with hs-cTnT (r= 0.40 P&lt; 0.001), age (r= 0.36 P&lt; 0.001), creatinine (r= 0.52 P&lt; 0.001), and amino-terminal pro-B type natriuretic peptide (NT-proBNP; r= 0.42 P&lt; 0.001).	Creatinine	149-159	arginine vasopressin	Homo sapiens	31-39
21527256-8	2011	At a cut-off value of 20U/g creatinine, ALP demonstrated a sensitivity and specificity of 83.8% and 36.8%, respectively.	Creatinine	28-38	alkaline phosphatase, placental	Homo sapiens	40-43
22813563-12	2011	The automatic reporting of eGFR each time a serum creatinine concentration is requested will increase the awareness of significant kidney dysfunction in clinical practice especially in DFU patients and appropriate measures will improve the outcome.	Creatinine	50-60	epidermal growth factor receptor	Homo sapiens	27-31
21667439-7	2011	In patients with postmenopausal osteoporosis, serum levels of sclerostin levels were significantly and positively related to serum calcium and creatinine levels.	Creatinine	143-153	sclerostin	Homo sapiens	62-72
21317676-16	2011	Logistic regression identified cyanosis, coadministration of furosemide, and baseline estimated creatinine clearance as independent risk factors for any degree of angiotensin-converting enzyme inhibitor-associated acute kidney injury (p &lt; .05).	Creatinine	96-106	angiotensin I converting enzyme	Homo sapiens	163-192
21908313-7	2011	Serum CRP was significantly related to P-Cl(Cr) (r = -0.83; P &lt; 0.001), plasma creatinine (r = 0.81; P &lt; 0.001), UP/UC (r = 0.70; P &lt; 0.001), and leukocytes (r = 0.49; P &lt; 0.01).	Creatinine	82-92	C-reactive protein	Canis lupus familiaris	6-9
21367916-6	2011	The ANG II+ANG-(1-7) coinfusion group showed a lower urinary albumin/creatinine ratio increase than the ANG II group.	Creatinine	69-79	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	4-10
21663693-7	2011	In Cox regression analyses adjusted for age, sex, WHO disease stage, CD4 cell count and haemoglobin, estimated creatinine clearance (CrCl) &lt; 60 mL/min was significantly associated with shorter times to meeting cART initiation criteria (HR 1.34; 95% CI, 1.23-1.52) and overall mortality (HR 1.73; 95% CI, 1.19-2.51) compared with CrCl &gt;=60 mL/min.	Creatinine	111-121	CD4 molecule	Homo sapiens	69-72
21430133-11	2011	A stepwise regression model revealed an 8.11 mug g(-1) creatinine increase per 1 p.p.m.	Creatinine	55-65	period circadian regulator 1	Homo sapiens	75-82
21430133-13	2011	A stepwise regression model revealed an increase of 6.04 mug g(-1) creatinine (95% CI 2.23-9.84) per 1 p.p.m.	Creatinine	67-77	period circadian regulator 1	Homo sapiens	97-104
21441208-6	2011	A screen of these deletion mutants revealed GAT1, encoding the only global transcription factor essential for utilization of a wide range of nitrogen sources, including uric acid, urea, and creatinine-three predominant nitrogen constituents found in the C. neoformans ecological niche.	Creatinine	190-200	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	44-48
22783291-4	2011	Major reasons for non-use of ACE inhibitors/ARBs were hyperkalemia and elevated serum creatinine level.	Creatinine	86-96	angiotensin I converting enzyme	Homo sapiens	29-32
21478207-7	2011	Multivariable regression analyses revealed that both IGF-I and IGFBP-3 concentrations were independently associated with waist circumference, fasting insulin and haemoglobin concentrations in boys (all P &lt; 0.05), systolic blood pressure, serum creatinine, fasting insulin and haemoglobin concentrations in girls (all P &lt; 0.05).	Creatinine	247-257	insulin like growth factor 1	Homo sapiens	53-58
21454717-1	2011	Estimation of the GFR (eGFR) using creatinine- or cystatin C-based equations is imperfect, especially when the true GFR is normal or near-normal.	Creatinine	35-45	epidermal growth factor receptor	Homo sapiens	23-27
21454717-7	2011	These results suggest that eGFR, calculated using standard creatinine- or cystatin C-based equations, partially depends on factors other than the true GFR.	Creatinine	59-69	epidermal growth factor receptor	Homo sapiens	27-31
21080031-7	2011	Fibrinogen levels were linearly associated with baseline glycaemia (P &lt; 0.017), WBC count (P &lt; 0.0001), creatinine (P &lt; 0.0001), and Platelet count (P &lt; 0.0001) but inversely associated with RBC count (P &lt; 0.0001).	Creatinine	110-120	fibrinogen beta chain	Homo sapiens	0-10
21525989-8	2011	Furthermore, plasma FGF21 level correlated positively with creatinine, blood urea nitrogen (BUN), beta2 microglobulin, systolic pressure, adiponectin, phosphate, proteinuria, CRP and triglyceride, but negatively with creatinine clearance rate (CCR), estimated glomerular filtrate rate (eGFR), HDL-c, LDL-c, albumin and LVH after adjusting for BMI, gender, age and the presence of diabetes mellitus.	Creatinine	59-69	fibroblast growth factor 21	Homo sapiens	20-25
21525989-8	2011	Furthermore, plasma FGF21 level correlated positively with creatinine, blood urea nitrogen (BUN), beta2 microglobulin, systolic pressure, adiponectin, phosphate, proteinuria, CRP and triglyceride, but negatively with creatinine clearance rate (CCR), estimated glomerular filtrate rate (eGFR), HDL-c, LDL-c, albumin and LVH after adjusting for BMI, gender, age and the presence of diabetes mellitus.	Creatinine	217-227	fibroblast growth factor 21	Homo sapiens	20-25
21289055-8	2011	Rats pretreated with IKKbeta siRNA had significantly less blood urea nitrogen and serum creatinine levels and less renal tubular damage scores.	Creatinine	88-98	inhibitor of nuclear factor kappa B kinase subunit beta	Rattus norvegicus	21-28
21185419-5	2011	RESULTS: In both postmenopausal women and men, multiple regression analysis adjusted for age, body mass index, and serum creatinine showed that serum osteocalcin level was significantly and negatively associated with fasting plasma glucose, HbA(1c), %Trunk fat, and homeostasis model assessment (HOMA) for insulin resistance (p&lt;0.05), and positively with HOMA for beta-cell function (p&lt;0.05).	Creatinine	121-131	bone gamma-carboxyglutamate protein	Homo sapiens	150-161
21418176-8	2011	In the general population, evaluation of erythropoietin levels is prompted by the combination of anaemia and abnormal serum creatinine.	Creatinine	124-134	erythropoietin	Homo sapiens	41-55
21389974-8	2011	The urine HGFIN-to-creatinine ratio increased over time after 5/6 nephrectomy; increased in patients with proteinuric and polycystic kidney disease; and remained detectable in urine after prolonged freezer storage.	Creatinine	19-29	glycoprotein nmb	Homo sapiens	10-15
20532480-8	2011	Multiple logistic regression analysis adjusted for age, duration of diabetes, body mass index, serum creatinine, and HbA(1c) showed that serum IGF-I level was inversely associated with the presence of one VF [odds ratio (OR) = 0.67, p = 0.029], two VFs (OR = 0.40, p = 0.017), as well as three and more VFs (OR = 0.27, p = 0.005).	Creatinine	101-111	insulin like growth factor 1	Homo sapiens	143-148
21462079-9	2011	Correlation studies showed a significant association between creatinine level, and each of MDA (r = 0.91), GSH (r = -0.87), and TNF-alpha (0.91).	Creatinine	61-71	tumor necrosis factor	Rattus norvegicus	128-137
20935018-8	2011	Cr, BUN, cystatin C and IL-6 levels in the EPO group were lower than those in the Control group at most of the observation points.	Creatinine	0-2	erythropoietin	Homo sapiens	43-46
21486581-9	2011	The average values of creatinine and urea were lower after conversion to mTOR (P &lt; .05) with a 6.9% incidence of acute rejection episodes.	Creatinine	22-32	mechanistic target of rapamycin kinase	Homo sapiens	73-77
21530806-6	2011	After treatment, the homocysteine level was reduced to 1.13 +- 0.44 and 1.33 +- 0.39 mmol/mol creatinine for A1 and A2 groups, respectively.	Creatinine	94-104	BCL2 related protein A1	Homo sapiens	109-118
21192318-12	2011	The Delta(creatinine) % increase correlated significantly with the Delta(PTH) % decrease at month 1 and 12.	Creatinine	10-20	parathyroid hormone	Homo sapiens	73-76
21303875-3	2011	The most common biochemical method used to distinguish between PHP and FHH is the urine calcium-to-creatinine ratio (UCCR).	Creatinine	99-109	calcium sensing receptor	Homo sapiens	71-74
20804479-6	2011	The urinary NGF/creatinine (Cr) levels were significantly highest in OAB-wet (2.13 +- 3.87) and second highest in OAB-dry (0.265 +- 0.59) compared to controls (0.07 +- 0.21).	Creatinine	16-26	nerve growth factor	Homo sapiens	12-15
21518598-9	2011	However, the eGFR was significantly lower ((72.0 +- 12.5) ml min(-1) 1.73 m(-2) vs. (82.0 +- 16.5) ml min(-1) 1.7 m(-2), P = 0.010), and the basic serum creatinine level ((1.07 +- 0.12) mg/dl vs. (0.97 +- 0.19) mg/dl P = 0.014) was significantly higher in the CIN group.	Creatinine	153-163	epidermal growth factor receptor	Homo sapiens	13-17
21282491-13	2011	Multivariable modeling confirmed that LRG is a stronger identifier of HF than BNP and this is independent of age, sex, creatinine, ischemia, beta-blocker therapy, and BNP.	Creatinine	119-129	leucine rich alpha-2-glycoprotein 1	Homo sapiens	38-41
21285386-0	2011	Urine C-peptide creatinine ratio is a noninvasive alternative to the mixed-meal tolerance test in children and adults with type 1 diabetes.	Creatinine	16-26	insulin	Homo sapiens	6-15
20836698-7	2011	Ang II-treated animals had higher levels of superoxide anion and inducible nitric oxide synthase and increased urinary protein and plasma creatinine levels.	Creatinine	138-148	angiotensinogen	Homo sapiens	0-6
21160484-6	2011	A novel Japanese equation was used to estimate the GFR: eGFR=194x(serum creatinine)(-1.094)x(age)(-0.287)(x0.739 if female).	Creatinine	72-82	epidermal growth factor receptor	Homo sapiens	56-60
20709741-0	2011	Serum ratio of soluble triggering receptor expressed on myeloid cells-1 to creatinine is a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.	Creatinine	75-85	myeloperoxidase	Homo sapiens	136-151
20709741-10	2011	CONCLUSIONS: The serum ratio of soluble TREM-1 to creatinine may be a useful marker for detection of infectious complications in MPO-ANCA-associated vasculitis.	Creatinine	50-60	myeloperoxidase	Homo sapiens	129-132
21440743-11	2011	Also, infused patients showed a positive correlation between circulating levels of IL-17 and IL-10 (r=0.692; P=.006), and an inverse correlation between serum creatinine and TGF-beta1 levels (r=-0.580; P=.03).	Creatinine	159-169	transforming growth factor beta 1	Homo sapiens	174-183
21352605-7	2011	CRT, taurine transporter (TauT/SLC6A6) and organic cation transporter (OCT3/SLC22A3) expressed at the BCSFB are involved in guanidinoacetic acid or creatinine efflux transport from CSF.	Creatinine	148-158	calcitonin receptor	Homo sapiens	0-3
21219402-8	2011	The Cockcroft Gault estimate of creatinine clearance calculated using ideal bodyweight gave the best estimate of gentamicin clearance (mean error -0.15 ml min(-1), 95% CI -2.67, 2.39).	Creatinine	32-42	CD59 molecule (CD59 blood group)	Homo sapiens	155-161
20660475-14	2011	One should be aware of possible limitations of creatinine-based eGFR formulas in patients with a nephrotic syndrome.	Creatinine	47-57	epidermal growth factor receptor	Homo sapiens	64-68
21088975-7	2011	Renal function was estimated using the glomerular filtration rate (eGFR) based upon creatinine levels, and body weight (Leger formula).	Creatinine	84-94	epidermal growth factor receptor	Homo sapiens	67-71
21219665-10	2011	CD34+ cell counts in response to glucose challenge inversely correlated with neutrophil counts (rho = -0.330, p = 0.019), while post load counts of CD133+CD34+ cells inversely correlated with serum creatinine (rho = -0.312, p = 0.023).	Creatinine	198-208	CD34 molecule	Homo sapiens	154-158
21173131-7	2011	The CART model used 6 of 24 variables (iPTH, calcium, creatinine, renal transplantation, percentage of females, and urea nitrogen) and had a misclassification error rate of 0.194 (27/139).	Creatinine	54-64	CART prepropeptide	Homo sapiens	4-8
21245596-7	2011	OX40 expression correlated positively with both serum creatinine levels and SLEDAI.	Creatinine	54-64	TNF receptor superfamily member 4	Homo sapiens	0-4
21059827-5	2011	After adjusting for traditional cardiac risk factors, creatinine clearance, B-type natriuretic peptide, and high-sensitivity C-reactive protein (hsCRP), increased MPO concentrations remained significantly associated with incident MACEs over the ensuing 3-year period (HR 1.71; 95% CI 1.27-2.30, P &lt; 0.001).	Creatinine	54-64	myeloperoxidase	Homo sapiens	163-166
21617322-6	2011	Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively).	Creatinine	168-178	fatty acid binding protein 3	Homo sapiens	54-60
22239038-6	2011	Validation involving un-centrifuged urine samples demonstrated the following TGF-beta1 assay characteristics: linearity from 23 to 1286 pg/mL, recovery from 95 to 116%; precision: &lt; 17%; analytical specificity 3 pg/mL; reference interval from 0 to 39 pg/mg creatinine; freeze-thaw stability: after first thawing, urine samples could loose from 5 to 40% of TGF-beta1 activity on each following freeze-thaw circle.	Creatinine	260-270	transforming growth factor beta 1	Homo sapiens	77-86
21625111-3	2011	The consensus definitions of RIFLE and AKIN are based on changes in creatinine and urine output and define classes of severity within AKI.	Creatinine	68-78	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	29-34
22032777-5	2011	The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels.	Creatinine	58-68	natriuretic peptide A	Homo sapiens	16-19
22032777-5	2011	The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels.	Creatinine	157-167	natriuretic peptide A	Homo sapiens	16-19
22032777-6	2011	A meta-analysis showed that ANP infusion significantly decreased peak serum creatinine levels, incidence of arrhythmia and renal replacement therapy.	Creatinine	76-86	natriuretic peptide A	Homo sapiens	28-31
21204265-9	2011	Accordingly, urinary Hsp72 was significantly increased in patients with clinical AKI before serum creatinine elevation.	Creatinine	98-108	heat shock protein family A (Hsp70) member 1A	Homo sapiens	21-26
20825465-11	2011	Using the same model, log leptin and log adiponectin presented positive and negative associations, respectively with LTE(4) /creatinine in urine.	Creatinine	125-135	adiponectin, C1Q and collagen domain containing	Homo sapiens	41-52
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	vascular endothelial growth factor A	Homo sapiens	126-130
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	interleukin 6	Homo sapiens	132-136
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	interleukin 6	Homo sapiens	142-145
21673461-7	2011	In patients with high L-FABP group (baseline L-FABP &gt;= 11 microg/g creatinine; n = 18), the urinary L-FABP level was significantly decreased (1.52 +- 0.45 to 1.26 +- 0.43 microg/g creatinine, p &lt; 0.01).	Creatinine	70-80	fatty acid binding protein 1	Homo sapiens	22-28
21673461-7	2011	In patients with high L-FABP group (baseline L-FABP &gt;= 11 microg/g creatinine; n = 18), the urinary L-FABP level was significantly decreased (1.52 +- 0.45 to 1.26 +- 0.43 microg/g creatinine, p &lt; 0.01).	Creatinine	183-193	fatty acid binding protein 1	Homo sapiens	22-28
21673461-8	2011	In the limited 23 patients with microalbuminuria, the L-FABP level was significantly decreased [1.20 +- 0.62 to 1.03 +- 0.49 log(microg/g creatinine), p = 0.042], although the LDL-cholesterol level (139 +- 28 to 129 +- 23 mg/dL, p = 0.08) only showed a tendency to decrease.	Creatinine	138-148	fatty acid binding protein 1	Homo sapiens	54-60
21512281-12	2011	The ALP activity induced in RAGE-overexpressing HASMCs by human serum was positively correlated with the serum creatinine level, but not with phosphate and hemoglobin A1c levels.	Creatinine	111-121	alkaline phosphatase, placental	Homo sapiens	4-7
21737961-15	2011	In linear regression analysis, PON1 was a predictor of cf-PWV in a model that included age, gender, diabetes, mean arterial pressure, urine protein level, creatinine clearance and PON 1.	Creatinine	155-165	paraoxonase 1	Homo sapiens	31-35
19751258-9	2010	Using receiver operating characteristic curves for assessing urinary NGF/Cr levels in patients with IC/BPS and IBS, IC/BPS was diagnosed with a sensitivity and specificity of 75% and 65.5%, respectively, based on a urinary NGF/Cr threshold of 0.015.	Creatinine	227-229	nerve growth factor	Homo sapiens	69-72
20881939-8	2011	Serum log(10) vascular endothelial growth factor was positively correlated with renal and cardiac structure, but negatively with creatinine clearance.	Creatinine	129-139	vascular endothelial growth factor A	Homo sapiens	14-48
21655212-9	2011	The expression of podocalyxin, CD2-AP, alpha-actin4, and podocin mRNA correlated with serum creatinine (r = 0.457, p = 0.001; r = 0.329, p = 0.01; r = 0.286, p = 0.021; r = 0.357, p = 0.006, respectively).	Creatinine	92-102	podocalyxin like	Homo sapiens	18-29
21655212-9	2011	The expression of podocalyxin, CD2-AP, alpha-actin4, and podocin mRNA correlated with serum creatinine (r = 0.457, p = 0.001; r = 0.329, p = 0.01; r = 0.286, p = 0.021; r = 0.357, p = 0.006, respectively).	Creatinine	92-102	NPHS2 stomatin family member, podocin	Homo sapiens	57-64
20888212-10	2010	We obtained a similar trend that can reduce the fluctuation in the urinary transferrin concentration from three different samples by calibrating the creatinine concentration.	Creatinine	149-159	transferrin	Homo sapiens	75-86
20956731-6	2010	cGMP/creatinine was suppressed in patients on VEGF inhibitors (0.28 versus 0.39 pmol/mug; P = 0.01), with a trend toward suppression of nitrate/creatinine (0.46 versus 0.62 mumol/mg; P = 0.09).	Creatinine	5-15	vascular endothelial growth factor A	Homo sapiens	46-50
20851589-13	2010	Notable correlation was detected between serum creatinine level and each of MDA (r=0.85), TNF-alpha (r=0.85) and GSH (r=-0.81).	Creatinine	47-57	tumor necrosis factor	Rattus norvegicus	90-99
20665127-5	2010	Once induced via MyoD expression, hUCS-MSCs exhibited many cellular signs of myogenic conversion within 5 days and became capable of forming multinucleated myofibers, which exhibited all functional markers of fusion machinery such as beta-catenin, neural cell adhesion molecule and M-cadherin as well as muscle cell-specific structural proteins including desmin, alpha-actinin, dystrophin, myosin heavy chain, and myoglobin together with muscle-specific enzyme, creatinine phosphokinase.	Creatinine	462-472	myogenic differentiation 1	Homo sapiens	17-21
20189611-7	2011	AST-120 treatment (6 g/d), but not control treatment, for 12 months significantly reduced IL-6, proteinuria, and urinary excretion levels of L-FABP and 8-OHdG, and inhibited the increase in serum creatinine in CRF patients.	Creatinine	196-206	solute carrier family 17 member 5	Homo sapiens	0-3
20059584-7	2010	ED defined by IIEF-5 was associated with advanced age [OR = 1.12 (95% CI 1.06-1.17), p &lt; 0.0001], use of insulin therapy [OR = 2.94 (95% CI 1.12-7.73), p = 0.029] and urinary albumin-creatinine ratio [OR = 2.29 (95% CI 1.05-5.01), p = 0.037].	Creatinine	186-196	insulin	Homo sapiens	108-115
20100732-0	2010	A comparison of three methods to estimate baseline creatinine for RIFLE classification.	Creatinine	51-61	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	66-71
20100732-1	2010	BACKGROUND: A pre-morbid "baseline" creatinine is required in order to diagnose and stage acute kidney injury (AKI) using the RIFLE classification.	Creatinine	36-46	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	126-131
20100732-10	2010	CONCLUSIONS: Estimates of incidence of AKI in the critically ill using RIFLE classification can be affected by the bias and limited accuracy of methods to estimate baseline creatinine.	Creatinine	173-183	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	71-76
21168678-10	2010	Plasma copeptin, estimated using a commercially available kit, was correlated with kidney function parameters of creatinine, estimated GFR by MDRD and CKD-EPI, NT-proBNP and ejection fraction.	Creatinine	113-123	arginine vasopressin	Homo sapiens	7-15
22314953-8	2010	Also, CCL4 produced significant increase in serum blood urea nitrogen (BUN) and creatinine compared with normal rats.	Creatinine	80-90	C-C motif chemokine ligand 4	Rattus norvegicus	6-10
19751258-11	2010	CONCLUSIONS: Urinary NGF/Cr levels are elevated in women with IC/BPS or DO, but not in those with IBS.	Creatinine	25-27	nerve growth factor	Homo sapiens	21-24
20844196-7	2010	In response to cisplatin treatment, IL-10 knockout mice showed more rapid and greater increases in blood urea nitrogen and serum creatinine compared with wild-type mice, indicating that endogenous IL-10 ameliorates kidney injury in cisplatin nephrotoxicity.	Creatinine	129-139	interleukin 10	Mus musculus	36-41
20844196-7	2010	In response to cisplatin treatment, IL-10 knockout mice showed more rapid and greater increases in blood urea nitrogen and serum creatinine compared with wild-type mice, indicating that endogenous IL-10 ameliorates kidney injury in cisplatin nephrotoxicity.	Creatinine	129-139	interleukin 10	Mus musculus	197-202
21526629-8	2010	Creatinine clearance was significantly lower in subjects compared to controls 98.86 +/- 21.26 mI/min/1.72m2 vs. 108.18 +/- 25.16 mI/min/1.72m2 (p = 0.002).	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	97-102
20508651-8	2010	On the other hand, the impact of some clinical and laboratory parameters of our diabetic patients on the serum VEGF revealed significant positive correlations between serum VEGF and age of the patients, duration of diabetes, systolic and diastolic blood pressure, body mass index, fasting and 2-h postprandial blood glucose, HbA(1c), serum creatinine, degree of albuminuria and total cholesterol, LDL, and platelet count.	Creatinine	340-350	vascular endothelial growth factor A	Homo sapiens	111-115
20508651-8	2010	On the other hand, the impact of some clinical and laboratory parameters of our diabetic patients on the serum VEGF revealed significant positive correlations between serum VEGF and age of the patients, duration of diabetes, systolic and diastolic blood pressure, body mass index, fasting and 2-h postprandial blood glucose, HbA(1c), serum creatinine, degree of albuminuria and total cholesterol, LDL, and platelet count.	Creatinine	340-350	vascular endothelial growth factor A	Homo sapiens	173-177
20713426-7	2010	Urinary cotinine/creatinine ratio increased with the number of cigarettes smoked (C0: 11 +- 7 ng/mg; C10: 961 +- 539 ng/mg; C20: 1821 +- 312 ng/mg), with levels in the C10 and C20 groups in keeping with values published in infants exposed to ETS.	Creatinine	17-27	homeobox C10	Homo sapiens	101-104
20837184-8	2010	The values of GSA and GAA corrected by the ratios of the individual compounds to creatinine were significantly increased in DM mice compared with control mice.	Creatinine	81-91	glucosidase, alpha, acid	Mus musculus	22-25
21034550-1	2010	BACKGROUND: Serum creatinine (Scr) measurement plays a key role in glomerular filtration rate estimation (eGFR), chronic kidney disease (CKD) diagnosis as well as CKD treatment.	Creatinine	18-28	epidermal growth factor receptor	Homo sapiens	106-110
20447677-6	2010	Large amounts of podocalyxin were shed into both the urine sediment (17.2 +/- 3.2 ng/mg creatinine) and the supernatant (172.6 +/- 24.6 ng/mg creatinine) of patients, compared with the small amounts of urinary podocalyxin in healthy controls (sediment, 0.5 +/- 0.1 ng/mg creatinine; supernatant, 24.3 +/- 3.5 ng/mg creatinine).	Creatinine	88-98	podocalyxin like	Homo sapiens	17-28
20447677-6	2010	Large amounts of podocalyxin were shed into both the urine sediment (17.2 +/- 3.2 ng/mg creatinine) and the supernatant (172.6 +/- 24.6 ng/mg creatinine) of patients, compared with the small amounts of urinary podocalyxin in healthy controls (sediment, 0.5 +/- 0.1 ng/mg creatinine; supernatant, 24.3 +/- 3.5 ng/mg creatinine).	Creatinine	142-152	podocalyxin like	Homo sapiens	17-28
20447677-6	2010	Large amounts of podocalyxin were shed into both the urine sediment (17.2 +/- 3.2 ng/mg creatinine) and the supernatant (172.6 +/- 24.6 ng/mg creatinine) of patients, compared with the small amounts of urinary podocalyxin in healthy controls (sediment, 0.5 +/- 0.1 ng/mg creatinine; supernatant, 24.3 +/- 3.5 ng/mg creatinine).	Creatinine	142-152	podocalyxin like	Homo sapiens	17-28
20447677-6	2010	Large amounts of podocalyxin were shed into both the urine sediment (17.2 +/- 3.2 ng/mg creatinine) and the supernatant (172.6 +/- 24.6 ng/mg creatinine) of patients, compared with the small amounts of urinary podocalyxin in healthy controls (sediment, 0.5 +/- 0.1 ng/mg creatinine; supernatant, 24.3 +/- 3.5 ng/mg creatinine).	Creatinine	142-152	podocalyxin like	Homo sapiens	17-28
20535121-8	2010	Furthermore, serum PlGF concentrations of pre-eclamptic patients showed significant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin.	Creatinine	267-277	placental growth factor	Homo sapiens	19-23
20045535-4	2010	Multiple regression analysis adjusted for age, duration of diabetes, sex, body height, body weight, waist circumference, serum creatinine, and hemoglobin A(1c) showed that serum total adiponectin was still significantly and positively correlated with percentage change in FN-BMD (r = 0.65, P &lt; .01).	Creatinine	127-137	adiponectin, C1Q and collagen domain containing	Homo sapiens	184-195
20566738-6	2010	The most striking finding is that renal cell TLR4 stimulation increases glomerular crescent formation, with a mean of 21% and 25% in the two groups of mice with renal cell TLR4 compared with 0.1% and 0.6% in the two groups without, with differences mirrored by changes in serum creatinine.	Creatinine	278-288	toll-like receptor 4	Mus musculus	45-49
20734449-8	2010	RESULTS: At survival analysis, both CRP and ACR were associated with increased risk of 10-year all-cause mortality, also after adjusting for age, hypertension, diabetes mellitus, prehospital time delay, creatine kinase-MB isoenzyme peak, heart failure, and creatinine clearance.	Creatinine	257-267	C-reactive protein	Homo sapiens	36-39
20630133-10	2010	RESULTS: PPV for cystatin C-eGFR (65%) was better than for creatinine-eGFR (48%).	Creatinine	59-69	epidermal growth factor receptor	Homo sapiens	70-74
20395257-7	2010	VEGF expression and activity could be linked with indicators of renal injury such as glomerular proliferation and creatinine, respectively.	Creatinine	114-124	vascular endothelial growth factor A	Homo sapiens	0-4
20400449-5	2010	RESULTS: The unadjusted median eGFR at the start of dialysis was 7.0 mL/min/1.73 m(2) in the 1999 data (median serum creatinine 7.5 mg/dL) and 7.7 mL/min/1.73 m(2) in the 2003 data (serum creatinine 7.0 mg/dL).	Creatinine	188-198	epidermal growth factor receptor	Homo sapiens	31-35
20206981-13	2010	CONCLUSIONS: Determination of CRP in patients with renal colic due to urolithiasis provides an objective and useful parameter for deciding placement of urinary stent, which is even more valuable than leukocytosis or seric creatinine level.	Creatinine	222-232	C-reactive protein	Homo sapiens	30-33
20664700-7	2010	Duration of DM, insulin therapy, and serum creatinine levels were associated with increased mRNA level of ET-1, whereas medication with sulfonylurea or angiotensin-converting enzyme inhibitors had the opposite effect.	Creatinine	43-53	endothelin 1	Homo sapiens	106-110
20664700-9	2010	Long-standing clinical course of DR; medication with insulin, sulfonylurea, or ACE inhibitors; and serum creatinine levels are factors possibly associated with changes in ET-1 expression in PBMCs.	Creatinine	105-115	endothelin 1	Homo sapiens	171-175
20630133-12	2010	The average of cystatin C-eGFR and creatinine-eGFR yielded PPV 67% and NPV 92%.	Creatinine	35-45	epidermal growth factor receptor	Homo sapiens	46-50
20630133-13	2010	The agreement between creatinine-eGFR and GFR was better than the agreement between cystatin C-eGFR and GFR, but both were clinically unacceptable.	Creatinine	22-32	epidermal growth factor receptor	Homo sapiens	33-37
20452080-6	2010	In univariate analyses, FGF21 levels showed associations with a use of fibrates, triglyceride levels, creatinine levels, waist circumference, and BMI.	Creatinine	102-112	fibroblast growth factor 21	Homo sapiens	24-29
20452080-7	2010	Multiple regression analyses adjusted for age, gender and BMI showed that a use of fibrates, triglyceride levels and creatinine levels were strong contributors to serum FGF21 levels.	Creatinine	117-127	fibroblast growth factor 21	Homo sapiens	169-174
20211930-7	2010	In conclusion, HDL-C and apoA-I are inversely related to e-GFR and creatinine clearance in subjects without severely compromised kidney function, which fits the concept that the kidney contributes to apoA-I regulation in humans.	Creatinine	67-77	apolipoprotein A1	Homo sapiens	25-31
20395593-7	2010	In multivariable regression analyses that adjusted for age, gender, smoking, serum creatinine, and statin and estrogen use, osteocalcin levels in the highest quartile (compared with the lowest quartile) were associated with a lower odds ratio (OR) of having MetSyn: OR (95% CI) in blacks, 0.33 (0.23 to 0.46); OR in non-Hispanic whites, 0.43 (0.31 to 0.63).	Creatinine	83-93	bone gamma-carboxyglutamate protein	Homo sapiens	124-135
20581773-0	2010	Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients.	Creatinine	20-30	S100 calcium binding protein B	Homo sapiens	121-126
20581773-13	2010	CONCLUSIONS: BMI, creatinine clearance, and age are determinants of steady-state serum S100B concentrations in renal transplant recipients.	Creatinine	18-28	S100 calcium binding protein B	Homo sapiens	87-92
20362027-3	2010	D-GalN rats exhibited an increased hepato and nephro toxicity marker activities aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transpeptidase and total bilirubin level while urea, uric acid and creatinine and lipid profile.	Creatinine	241-251	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
20097344-11	2010	CONCLUSIONS: We concluded that the high plasma level of LDL-C was the major risk factor among coronary risk factors to reduce GFR probably due to impairing the function of renal arterioles and capillaries of glomeruli in subjects with normal kidney function assessed by urinalysis and plasma creatinine.	Creatinine	292-302	component of oligomeric golgi complex 2	Homo sapiens	56-61
20185732-6	2010	In a Cox regression model, baseline log u-LFABP levels predicted the development of microalbuminuria, adjusted for known risk factors (sex, age, A1C, systolic and diastolic blood pressure, albumin excretion rate, serum creatinine, and smoking) (hazard ratio [HR] 2.3 [95% CI 1.1-4.6]) and log u-LFABP predicted mortality (adjusted HR 3.0 [1.3-7.0]).	Creatinine	219-229	fatty acid binding protein 1	Homo sapiens	42-47
20424611-8	2010	A relationship was detected between creatinine clearance &lt;or=50 ml min(-1) and the development of non-bevacizumab-related grade 3/4 AEs.	Creatinine	36-46	CD59 molecule (CD59 blood group)	Homo sapiens	70-76
20164823-3	2010	Randomization to either placebo or two doses of erythropoietin was triggered by an increase in the biomarker concentration product to levels above 46.3, with a primary outcome of relative average plasma creatinine increase from baseline over 4 to 7 days.	Creatinine	203-213	erythropoietin	Homo sapiens	48-62
20157739-5	2010	We found that TGFbeta-1 excretion was significantly higher (p &lt; 0.001) in the patient group (median level 73 pg/mg creatinine) than in the HC (median level 28 pg/mg creatinine).	Creatinine	118-128	transforming growth factor beta 1	Homo sapiens	14-23
20157739-5	2010	We found that TGFbeta-1 excretion was significantly higher (p &lt; 0.001) in the patient group (median level 73 pg/mg creatinine) than in the HC (median level 28 pg/mg creatinine).	Creatinine	168-178	transforming growth factor beta 1	Homo sapiens	14-23
20006332-7	2010	At multivariate analysis, CETP polymorphism, apoA-I, triglycerides and BMI were independent determinants of HDL-C concentration in diabetic women; apo-A-I, triglycerides, age and creatinine in controls.	Creatinine	179-189	cholesteryl ester transfer protein	Homo sapiens	26-30
19727730-3	2010	S-1 (25-60 mg determined by the body surface area and creatinine clearance) was given orally, twice daily.	Creatinine	54-64	proteasome 26S subunit, non-ATPase 1	Homo sapiens	0-3
19818961-10	2010	Adjusting for other risk factors plus serum creatinine the varepsilon4 allele was associated with lower serum CRP under a dominant model, coefficient 0.089, p=0.002.	Creatinine	44-54	C-reactive protein	Homo sapiens	110-113
20485148-7	2010	Cutoff values for I-FABP (2.20 pg/nmol creatinine), claudin-3 (800.8 INT), and calprotectin (286.2 microg/g feces) showed clinically relevant positive likelihood ratios (LRs) of 9.30, 3.74, 12.29, and negative LRs of 0.08, 0.36, 0.15, respectively.	Creatinine	39-49	fatty acid binding protein 2	Homo sapiens	18-24
20495311-4	2010	Significant factors which affected the reduction or discontinuation of S-1 due to adverse reactions were 1) serum albumin value (Alb) (odds ratio 9.227; 95% confidence interval 1.056-80.603, p=0.0196) and 2) creatinine clearance value (Ccr) (odds ratio 5.850; 95% confidence interval 1.	Creatinine	208-218	proteasome 26S subunit, non-ATPase 1	Homo sapiens	71-74
20171655-7	2010	Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 +/- 310.9 vs 115.0 +/- 65.9 ng/g urinary creatinine; P &lt; .01), as were PI values (1.85 +/- 0.70 vs 1.44 +/- 0.53; P &lt; .05).	Creatinine	127-137	interleukin 6	Homo sapiens	8-26
20491014-15	2010	A non-significant trend towards correlation between preoperative TNF-alpha and postoperative decrease of creatinine clearance was observed (R = -0.36, p = 0.05).	Creatinine	105-115	tumor necrosis factor	Homo sapiens	65-74
20084405-6	2010	To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	141-151	interleukin 6	Homo sapiens	76-80
20084405-6	2010	To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20084405-8	2010	In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p&lt;0.05, R=0.305).	Creatinine	87-97	interleukin 6	Homo sapiens	82-86
20413036-8	2010	Serum creatinine was significantly lower in the hANP group than the placebo group at 1 month, 6 months, and 1 year post-operatively, whereas the estimated glomerular filtration rate was significantly higher in the hANP group at these times.	Creatinine	6-16	natriuretic peptide A	Homo sapiens	48-52
20596264-5	2010	RESULTS: All eGFR equations gave acceptable approximations to the timed urine collection creatinine clearances.	Creatinine	89-99	epidermal growth factor receptor	Homo sapiens	13-17
20186149-6	2010	The elevation of serum creatinine and urea nitrogen levels at 18 weeks of diabetes was more prominent in ACE2-KO mice.	Creatinine	23-33	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	105-109
21103678-6	2010	Considering admission SOFA score and trend of renal function (measured by daily renal SOFA scores, with daily measure of serum creatinine and diuresis), we hypothesize that ACE polymorphisms could influence in the trend of renal function in ICU patients.	Creatinine	127-137	angiotensin I converting enzyme	Homo sapiens	173-176
20385280-6	2010	Urinary i-FABP was quantified by enzyme-linked immunosorbent assay and expressed as picograms per nanomole creatinine (median [range]).	Creatinine	107-117	fatty acid binding protein 2	Homo sapiens	8-14
19940842-5	2010	A more extensive cross-sectional study found significant increases in urinary L-FABP, normalized to urinary creatinine, in 92 patients with established AKI compared with 62 patients without clinical evidence of AKI.	Creatinine	108-118	fatty acid binding protein 1	Homo sapiens	78-84
20034524-10	2010	PACAP was renoprotective in vivo and prevented the rise in blood urea nitrogen and creatinine in mice treated with cisplatin.	Creatinine	83-93	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
20204339-7	2010	Using receiver operating characteristics curve analysis, we found that the adjusted IL-8 level of 6.2 pg/mg creatinine can reach a sensitivity of 90% and specificity of 68% to detect urolithiasis.	Creatinine	108-118	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
20124891-0	2010	Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit.	Creatinine	6-16	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	38-43
20124891-6	2010	MEASUREMENTS AND MAIN RESULTS: A RIFLE score was calculated for each patient based on percent change of serum creatinine from baseline (risk = serum creatinine x1.5; injury = serum creatinine x2; failure = serum creatinine x3).	Creatinine	110-120	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	33-38
20124891-6	2010	MEASUREMENTS AND MAIN RESULTS: A RIFLE score was calculated for each patient based on percent change of serum creatinine from baseline (risk = serum creatinine x1.5; injury = serum creatinine x2; failure = serum creatinine x3).	Creatinine	149-159	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	33-38
20124891-6	2010	MEASUREMENTS AND MAIN RESULTS: A RIFLE score was calculated for each patient based on percent change of serum creatinine from baseline (risk = serum creatinine x1.5; injury = serum creatinine x2; failure = serum creatinine x3).	Creatinine	149-159	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	33-38
20124891-6	2010	MEASUREMENTS AND MAIN RESULTS: A RIFLE score was calculated for each patient based on percent change of serum creatinine from baseline (risk = serum creatinine x1.5; injury = serum creatinine x2; failure = serum creatinine x3).	Creatinine	149-159	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	33-38
19890623-8	2010	A significant reduction in 24 h excretion rate of 8-iso-PGF2alpha from 126 (47-248) to 62 (35-111] pmol/mmol of creatinine was observed in the add-on insulin group (p = 0.005) but not in the add-on OHA group.	Creatinine	112-122	insulin	Homo sapiens	150-157
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	84-86
19766615-0	2010	Measurement uncertainty of eGFR at low creatinine levels: be careful to not overestimate.	Creatinine	39-49	epidermal growth factor receptor	Homo sapiens	27-31
20104936-5	2010	The reasons for this include physician concerns regarding patient age and limited life expectancy and potential complications of ACE inhibitor or ARB use, specifically an increase in creatinine levels and hyperkalaemia.	Creatinine	183-193	angiotensin I converting enzyme	Homo sapiens	129-132
23148146-7	2010	A modest decrease in estimated glomerular filtration rate (eGFR) and increase in creatinine often occurs with ACE inhibitors or ARBs.	Creatinine	81-91	angiotensin I converting enzyme	Homo sapiens	110-113
21263192-4	2010	Urinary proepithelin level was expressed in ng/100 mg creatinine.	Creatinine	54-64	granulin precursor	Homo sapiens	8-20
21263192-5	2010	RESULTS: Urinary proepithelin was significantly higher in bladder cancer patients compared to control subjects (means: 17.5 +- 10 and 8.9 +- 3.5 ng/100 mg creatinine, respectively; p &lt; 0.001), and the test sensitivity and specificity to detect the presence of bladder cancer were 74.6 and 85.2%, respectively.	Creatinine	155-165	granulin precursor	Homo sapiens	17-29
21696056-2	2010	Despite initial treatment with CD20 antibody rituximab and intravenous immunoglobulin, the patient presented with a steady increase in serum creatinine and de novo proteinuria.	Creatinine	141-151	keratin 20	Homo sapiens	31-35
19836015-6	2010	Intermediate levels of 2-hydroxyphenanthrene (49-148ng/g creatinine), and 9-hydroxyfluorene (161-749ng/g creatinine) were also significantly associated with elevated CRP compared to the respective reference categories.	Creatinine	57-67	C-reactive protein	Homo sapiens	166-169
19836015-6	2010	Intermediate levels of 2-hydroxyphenanthrene (49-148ng/g creatinine), and 9-hydroxyfluorene (161-749ng/g creatinine) were also significantly associated with elevated CRP compared to the respective reference categories.	Creatinine	105-115	C-reactive protein	Homo sapiens	166-169
20606409-9	2010	Yet, vasopressin infusion may increase urine output, creatinine clearance and improve renal function in septic shock.	Creatinine	53-63	arginine vasopressin	Homo sapiens	5-16
20091495-3	2010	In most of the reported cases, anti-TNF agents were deemed successful on the basis of regression of proteinuria and either improvement or stabilization of creatinine clearance, while objective proof of renal amyloid regression either by serum amyloid P scintigraphy or biopsy is limited.	Creatinine	155-165	tumor necrosis factor	Homo sapiens	36-39
20882095-15	2010	Lower serum albumin levels at admission were correlated with greater decreases of creatinine after discharge (r= 0.42; p= 0.009) and larger length of stay (r= -0.61; p &lt; 0.001).	Creatinine	82-92	albumin	Homo sapiens	12-19
21077347-5	2010	We calculated the slope of reciprocal serum creatinine as the rate of renal function decline (delta1/Cr).	Creatinine	44-54	delta like non-canonical Notch ligand 1	Homo sapiens	94-103
19359150-3	2010	Plasma ADPN levels were directly correlated with age, HDL-C and creatinine, and inversely with BMI, triglycerides and glomerular filtration rate (GFR).	Creatinine	64-74	adiponectin, C1Q and collagen domain containing	Homo sapiens	7-11
19359150-4	2010	Multiple regression analysis identified plasma creatinine and HDL as the independent factors associated with ADPN plasma levels.	Creatinine	47-57	adiponectin, C1Q and collagen domain containing	Homo sapiens	109-113
20609189-5	2010	The apo A-IV level was positively associated with urea nitrogen and creatinine, and negatively associated with age, interleukin-6, the neutrophil/lymphocyte ratio, and maximum CIMT.	Creatinine	68-78	apolipoprotein A4	Homo sapiens	4-12
20609189-8	2010	On stepwise multivariate regression analysis, the serum apo A-IV level was independently associated with creatinine, the neutrophil/lymphocyte ratio, and the maximum CIMT.	Creatinine	105-115	apolipoprotein A4	Homo sapiens	56-64
20183825-2	2010	Creatinine is highly polar and analysis by RP chromatography using conventional stationary phases such as silica-bonded C8 and C18 is unsuitable.	Creatinine	0-10	Bardet-Biedl syndrome 9	Homo sapiens	127-130
19900436-0	2010	Propagation of uncertainty in creatinine to uncertainty in eGFR: pitfall and validation.	Creatinine	30-40	epidermal growth factor receptor	Homo sapiens	59-63
20078870-5	2010	In a secondary analysis we assessed the association of CRP with albuminuria (defined as albumin-to-creatinine ratio &gt; 30 mg/g).	Creatinine	99-109	C-reactive protein	Homo sapiens	55-58
20008137-5	2010	In addition, IL-6-deficient (IL-6(-/-)) mice exhibited exaggerated histopathological changes with higher blood urea nitrogen and creatinine levels.	Creatinine	129-139	interleukin 6	Mus musculus	13-17
20008137-5	2010	In addition, IL-6-deficient (IL-6(-/-)) mice exhibited exaggerated histopathological changes with higher blood urea nitrogen and creatinine levels.	Creatinine	129-139	interleukin 6	Mus musculus	29-33
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	88-90
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	88-90
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	88-90
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	88-90
20563465-6	2010	RESULTS: The mean serum creatinine levels postoperatively presented greater rise in G4 (G4&gt;G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4&gt;G1 and G4&gt;G3, P&lt;0.05; G1=G3 and G2=G4, P&gt;0.05).	Creatinine	24-34	chromosome 6 open reading frame 47	Homo sapiens	88-90
19333145-4	2009	Levels of TNF-alpha were significantly expressed 1 h after LPS administration, followed by 1) an increase in levels of tissue factor, factor VIIa, factor Xa, thrombin and plasminogen activator inhibitor 1; 2) unchanged levels of tissue factor pathway inhibitor; and 3) subsequent deposition of fibrin in kidney tissues, which led to the elevation of creatinine and blood urea nitrogen.	Creatinine	350-360	tumor necrosis factor	Rattus norvegicus	10-19
19958870-4	2009	METHODS: A computerized algorithm was implemented in January 2006 to calculate appropriate eptifibatide infusion dose (1 microg kg(-1) min(-1) for creatinine clearance &lt;50 mL/min or 2 microg kg(-1) min(-1) for creatinine clearance &gt;or=50 mL/min) using the Cockroft-Gault formula.	Creatinine	147-157	CD59 molecule (CD59 blood group)	Homo sapiens	135-141
19408098-5	2009	APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels.	Creatinine	132-142	apolipoprotein A1	Homo sapiens	0-5
20134257-6	2009	After 2 weeks of intensive insulin therapy in Type 2 diabetics, both the level of blood glucose and the level of urinary ICAM-1/urinary Cr ratio had a remarkable decrease compared with the basal values (p&lt;0.01).	Creatinine	136-138	insulin	Homo sapiens	27-34
20065370-8	2009	The serum level of I-PTH correlated positively with patient age (r=0.158, p=0.008) and serum creatinine level (r=0.138, p=0.021) and negatively with clearance of creatinine (r= -0.169, p=0.004).	Creatinine	93-103	parathyroid hormone	Homo sapiens	21-24
20065370-8	2009	The serum level of I-PTH correlated positively with patient age (r=0.158, p=0.008) and serum creatinine level (r=0.138, p=0.021) and negatively with clearance of creatinine (r= -0.169, p=0.004).	Creatinine	162-172	parathyroid hormone	Homo sapiens	21-24
20693945-7	2010	Also, these studies have indicated that screening should include measurement of serum creatinine for eGFR as well as urine albumin.	Creatinine	86-96	epidermal growth factor receptor	Homo sapiens	101-105
19884815-8	2009	However, the urinary angiotensinogen:creatinine ratio was significantly higher in patients than in control subjects (12.1 +/- 3.2 microg/g versus 4.2 +/- 0.7 microg/g).	Creatinine	37-47	angiotensinogen	Homo sapiens	21-36
19535078-8	2009	RESULTS: In women every doubling of creatinine excretion was associated with an approximate 60% decrease in risk for MACE (hazard ratio (HR) 0.41 [95%CI 0.26-0.64], P&lt;0.001) and 50% decrease in risk for all-cause mortality (HR: 0.52 [0.31-0.90], P=0.02) independent of age, smoking, CVD history, race, fasting insulin concentrations and components of the metabolic syndrome.	Creatinine	36-46	insulin	Homo sapiens	313-320
20033292-8	2009	Creatinine correlated significantly with C5DC (p = 0.001) and all C5DC/acylcarnitine ratios, mainly with C5DC/(C8 + C10), C5DC/C0, C5DC/C2, C5DC/C4, and C5DC/C8 (for all: p = 0.001).	Creatinine	0-10	homeobox C10	Homo sapiens	116-119
19640916-7	2009	In addition, MMP-1, -3, -7, -9 correlated significantly with leukocytes, MMP-1, and TIMP-1 with thrombocytes, MMP-8 with fibrinogen, and MMP-7 with creatinine.	Creatinine	148-158	TIMP metallopeptidase inhibitor 1	Homo sapiens	84-90
19522864-5	2009	Urinary NGF levels were further normalized to the concentration of urinary creatinine (NGF/Cr) and compared between control and IC/BPS subgroups at diagnosis and after treatment.	Creatinine	75-85	nerve growth factor	Homo sapiens	87-90
19468830-0	2009	The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans.	Creatinine	134-144	nitric oxide synthase 3	Homo sapiens	58-91
19713273-0	2009	Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide.	Creatinine	67-77	insulin	Homo sapiens	122-131
19468830-0	2009	The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans.	Creatinine	134-144	nitric oxide synthase 3	Homo sapiens	93-97
20006797-4	2009	In a subsample of this cohort without renal disease, followed up to 23 years, creatinine clearance declined by a mean of -0.75 mL/min/1.73 m(2) per year.	Creatinine	78-88	CD59 molecule (CD59 blood group)	Homo sapiens	130-135
19684507-2	2009	METHODS: We followed individuals enrolled in the Study of the Consequences Of the Protease inhibitor Era cohort for longitudinal changes in kidney function, defined as glomerular filtration rate estimated from serum creatinine (eGFR).	Creatinine	216-226	epidermal growth factor receptor	Homo sapiens	228-232
19367169-4	2009	Anterior STEMI was more frequent in insulin-resistant patients (P = 0.040), who showed higher values of probrain natriuretic peptide (P = 0.010), creatinine (P &lt; 0.001), creatinine phosphokinase and creatinine phosphokinase-MB (MB, isoenzyme present in the myocardium; P = 0.016 and P = 0.003, respectively).	Creatinine	146-156	insulin	Homo sapiens	36-43
19640904-4	2009	In a murine model, pretreating wild-type (WT) mice with a PPAR-alpha activator, docosahexaenoic acid (DHA), significantly reduced I/R-induced renal dysfunction (lowered serum creatinine and urea nitrogen levels), apoptotic responses (decreased apoptotic cell number and caspase-3, -8 activation), and NF-kappaB activation.	Creatinine	175-185	peroxisome proliferator activated receptor alpha	Mus musculus	58-68
19536068-4	2009	Carriers of zero, one, and two low-activity OCT1 alleles (Arg61Cys, Gly401Ser, 420del, or Gly465Arg) had mean renal clearances of 30.6, 33.1, and 37.1 l/h, respectively (P = 0.04, after adjustment for creatinine clearance and age).	Creatinine	201-211	solute carrier family 22 member 1	Homo sapiens	44-48
19502542-8	2009	U-LFABP correlates with the urinary albumin-to-creatinine ratio (R(2) = 0.54, P &lt; 0.001).	Creatinine	47-57	fatty acid binding protein 1	Homo sapiens	2-7
19509019-8	2009	Urinary adiponectin was significantly increased in type 2 diabetes (7.68 +/- 14.26 vs. control subjects: 2.91 +/- 3.85 microg/g creatinine, P = 0.008).	Creatinine	128-138	adiponectin, C1Q and collagen domain containing	Homo sapiens	8-19
19782259-7	2009	CONCLUSIONS: DM, serum creatinine, and PCWP were correlated with elevated baseline serum cTnT concentrations.	Creatinine	23-33	troponin T2, cardiac type	Homo sapiens	89-93
19907101-7	2009	Triglyceride and serum creatinine levels were associated with HMW adiponectin in men only.	Creatinine	23-33	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
19584179-6	2009	RESULTS: Creatinine clearance was positively correlated with BMI (r = 0.429; P &lt; 0.001), fasting glucose (r = 0.198; P = 0.001), and insulin levels (r = 0.125; P = 0.042), as well as IAF (r = 0.239; P &lt; 0.001), SCF (r = 0.281; P &lt; 0.001), and lean thigh (r = 0.353; P &lt; 0.001) areas.	Creatinine	9-19	insulin	Homo sapiens	136-143
19584179-7	2009	The association between creatinine clearance and BMI remained significant after adjustments for IAF, SCF areas, and fasting insulin levels (r = 0.337; P &lt; 0.001); whereas IAF and SCF areas were not independently associated with creatinine clearance after adjusting for BMI.	Creatinine	24-34	insulin	Homo sapiens	124-131
19584179-8	2009	Creatinine clearance increased with increasing BMI after adjusting for fasting insulin, fasting glucose, IAF and SCF areas in subjects with normal glucose tolerance (r = 0.432; P &lt; 0.001) and impaired glucose metabolism (r = 0.471; P &lt; 0.001).	Creatinine	0-10	insulin	Homo sapiens	79-86
19660275-8	2009	When long-term survival of patient groups was compared with expected survival, only patients with a creatinine clearance less than 30 mL x min(-1) showed a worse outcome.	Creatinine	100-110	CD59 molecule (CD59 blood group)	Homo sapiens	139-145
19660275-9	2009	Patients with a creatinine clearance between 60 and 90 mL x min(-1) had a long-term survival exceeding the expected survival.	Creatinine	16-26	CD59 molecule (CD59 blood group)	Homo sapiens	60-66
19577778-2	2009	GREM1 maps to human chromosome 15q12, a region previously found to be linked to albumin to creatinine ratio (ACR) in Mexican Americans.	Creatinine	91-101	gremlin 1, DAN family BMP antagonist	Homo sapiens	0-5
19796028-10	2009	Urinary VEGF levels showed a significant relationship with urinary albumin excretion, proteinuria, serum creatinine level and creatinine clearance, as well as fasting blood glucose levels, postprandial 2 h glucose levels and C-reactive protein.	Creatinine	105-115	vascular endothelial growth factor A	Homo sapiens	8-12
19796028-10	2009	Urinary VEGF levels showed a significant relationship with urinary albumin excretion, proteinuria, serum creatinine level and creatinine clearance, as well as fasting blood glucose levels, postprandial 2 h glucose levels and C-reactive protein.	Creatinine	126-136	vascular endothelial growth factor A	Homo sapiens	8-12
19784367-5	2009	RESULTS: PARP-1 expression showed a significant relationship with cold ischemia time (r coefficient = 0.603), time to effective diuresis (r = 0.770), serum creatinine levels at biopsy (r = 0.649), and degree of ATN (r = 0.810) (p = 0.001, Pearson test).	Creatinine	156-166	poly(ADP-ribose) polymerase 1	Homo sapiens	9-15
19572935-1	2009	BACKGROUND: The beneficial effects of vasopressin on diuresis and creatinine clearance have been demonstrated when used as an additional/alternative therapy in catecholamine-dependent vasodilatory shock.	Creatinine	66-76	arginine vasopressin	Homo sapiens	38-49
19734702-5	2009	By a logistic regression analysis, the following 3 factors were identified as independent preoperative risk factors for death within 30 days of the PEG: (1) high serum creatinine level [mg/dl, p=0.006, odds ratio (OR)=8.472]; (2) past history of ischemic heart disease [p=0.008, OR=9.985]; (3) low serum albumin level [g/dl, p=0.017, OR=0.096].	Creatinine	168-178	albumin	Homo sapiens	304-311
19450826-15	2009	Mean bladder urine transforming growth factor-beta1 levels in the first 3 months of life were 23 +/- 14 and 11.5 +/- 8 pg/mmol creatinine in the surgical and observational groups, respectively (p &lt;0.001).	Creatinine	127-137	transforming growth factor beta 1	Homo sapiens	19-51
19553348-4	2009	Renal function as assessed by plasma levels of both creatinine and blood urea nitrogen was significantly reduced in CypD knockout (CypD(-/-)) mice compared with wild-type mice during the 5-day post-ischemia period.	Creatinine	52-62	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	116-120
19387472-3	2009	Linkage of serum creatinine levels to loci on chromosomes 7p14, 9p21, 11p15, 15q15-21, 16p13, and 18p11 was successfully replicated in at least one discovery population or in the pooled analysis.	Creatinine	17-27	S100 calcium binding protein A10	Homo sapiens	100-103
19387472-8	2009	Our finding of a replicated association of serum creatinine with the MYH9 gene, recently linked to pathological renal conditions in African Americans, suggests that this gene may also influence kidney function in healthy Europeans.	Creatinine	49-59	myosin heavy chain 9	Homo sapiens	69-73
19615100-9	2009	The covariates independently associated with elevated cTnT were increasing neutrophil count, creatinine concentration, heart rate and Cardiac Infarction Injury Score (CIIS), and decreasing hemoglobin concentration.	Creatinine	93-103	troponin T2, cardiac type	Homo sapiens	54-58
19681411-2	2009	As well as insulin-dependent diabetic patients and patients with elevated creatinine (&gt; 178 micromol/l) as previously found, our study suggests that non-insulin-dependent diabetic patients and patients with creatinine &gt; 120 micromol/l are also at increased risk of cardiac complications and death following non-cardiac surgery.	Creatinine	210-220	insulin	Homo sapiens	11-18
19366711-11	2009	The significant relationship between raised cTnT and survival was retained in Cox multivariate analysis adjusted for total ICD energy delivered during an arrhythmia episode, age, sex, presence of coronary artery disease, left ventricular ejection fraction and serum creatinine.	Creatinine	266-276	troponin T2, cardiac type	Homo sapiens	44-48
19450826-17	2009	At a cutoff of 17 pg/mmol creatinine bladder urine transforming growth factor-beta1 in the first 3 months of life was 82% sensitive and 86% specific in predicting surgery.	Creatinine	26-36	transforming growth factor beta 1	Homo sapiens	51-83
19461033-9	2009	CONCLUSIONS: In a large, consecutive series of prospectively enrolled patients with aneurysmal subarachnoid hemorrhage, we demonstrate, using the newly defined RIFLE classification for risk of renal failure, that even seemingly insignificant decreases in creatinine clearance are associated with significantly worse 3-month outcomes.	Creatinine	255-265	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	160-165
19349297-0	2009	A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury.	Creatinine	51-61	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	83-88
19349297-1	2009	BACKGROUND: The RIFLE classification scheme for acute kidney injury (AKI) is based on relative changes in serum creatinine (SCr) and on urine output.	Creatinine	112-122	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	16-21
19715926-11	2009	Mean serum creatinine was 1.44 mg/dL with Modification of Diet in Renal Disease (MDRD) clearance of 76 mL/min/1.73 m(2).	Creatinine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	106-111
19344973-8	2009	But, there was a positive correlation between apelin levels and urinary albumin/creatinine ratio.	Creatinine	80-90	apelin	Homo sapiens	46-52
19272447-7	2009	The level of urinary PRL (21.6+/-10.6 micromol/mol of creatinine) significantly correlated with the other oxidative stress markers, 8-oxo-deoxyguanosine, dityrosine, and isoprostanes.	Creatinine	54-64	prolactin	Homo sapiens	21-24
19111631-5	2009	Within the acute rejection group, a positive staining for CD20 was not associated with graft loss, steroid resistance or lack of return to basal creatinine after treatment, but was associated with higher serum creatinine at 3 and 6 months, 1 and 2 years after the acute episode (p&lt;0.05).	Creatinine	145-155	keratin 20	Homo sapiens	58-62
19111631-5	2009	Within the acute rejection group, a positive staining for CD20 was not associated with graft loss, steroid resistance or lack of return to basal creatinine after treatment, but was associated with higher serum creatinine at 3 and 6 months, 1 and 2 years after the acute episode (p&lt;0.05).	Creatinine	210-220	keratin 20	Homo sapiens	58-62
19111631-7	2009	Patients with clusters of CD20+ cells &gt;50/HPF had higher serum creatinine after 2 years of follow up.	Creatinine	66-76	keratin 20	Homo sapiens	26-30
19413314-3	2009	Reduction of the bimetallic dicarbonyl with borohydride salts afforded impure, thermally stable hydride, [(CO)(dppe)Fe(pdt)(mu-H)Ni(dppe)](+) ([2H](+)).	Creatinine	48-55	familial progressive hyperpigmentation 1	Homo sapiens	124-128
19228823-8	2009	Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P&lt;0.05).	Creatinine	77-87	alpha 2-HS glycoprotein	Homo sapiens	35-43
19242728-7	2009	We found a significant but weak inverse correlation between insulin sensitivity and creatinine clearance in NAFLD patients (r (s) = -0.25;p = 0.02).	Creatinine	84-94	insulin	Homo sapiens	60-67
19323980-9	2009	Urinary albumin to creatinine ratio in ESAM-/- mice was significantly higher than in ESAM+/+ mice.	Creatinine	19-29	endothelial cell-specific adhesion molecule	Mus musculus	39-43
19426682-7	2009	Metformin, which was also an anti-diabetic agent, and creatinine more potently inhibited the uptake of [(14)C]aminoguanidine by hOCT2 than that by hOCT1.	Creatinine	54-64	solute carrier family 22 member 1	Homo sapiens	147-152
19353463-4	2009	Glomerular filtration rate was estimated (eGFR) on the basis of creatinine and cystatin C serum concentrations.	Creatinine	64-74	epidermal growth factor receptor	Homo sapiens	42-46
19395784-7	2009	The mean pretreatment ratio of urinary TNF-alpha to urinary creatinine level was higher than that 3 days after starting on empirical treatment (P = .03).	Creatinine	60-70	tumor necrosis factor	Homo sapiens	39-48
19259574-1	2009	New homo- and hetero-dimetallic complexes bridged by diphenyl-2-pyridylphosphine and hydrides [(CpIr)(micro-PPh(2)Py)(mu-H)(2)(MCp)][OTf](n) (: M = Ir, n = 2; : M = Rh, n = 2; : M = Ru, n = 1) were synthesized.	Creatinine	85-93	CD46 molecule	Homo sapiens	127-130
19177462-8	2009	The ELISA data also demonstrated that urinary sE-cadherin-to-creatinine ratio was significantly increased in DN1 and DN2 groups versus DM group or control group (2751.5+/-164 and 5839.6+/-428 vs 721.9+/-93 or 652.7+/-87 microg/g; p&lt;0.001).	Creatinine	61-71	immunoglobulin heavy diversity 6-13	Homo sapiens	109-112
20031592-5	2009	The same HNF1A coding variants were associated with higher low-density lipoprotein cholesterol, apolipoprotein B, creatinine, and fibrinogen in EA.	Creatinine	114-124	HNF1 homeobox A	Homo sapiens	9-14
18848325-5	2009	Creatinine-based estimated glomerular filtration rate (eGFR(creat)) was calculated using the MDRD equation.	Creatinine	0-10	epidermal growth factor receptor	Homo sapiens	55-66
19426682-3	2009	Guanidine, creatinine and aminoguanidine more markedly inhibited the uptake of [(14)C]tetraethylammonium (TEA) by hOCT2 than by hOCT1.	Creatinine	11-21	solute carrier family 22 member 1	Homo sapiens	128-133
19341447-11	2009	Significant association was detected between creatinine level and those of MDA (r = 0.81), TNF-alpha ) r = 0.92) and GSH (r = -0.82); implying causal relationships.	Creatinine	45-55	tumor necrosis factor	Rattus norvegicus	91-100
19395784-9	2009	CONCLUSIONS: Based on our findings in children, the level of urinary TNF-alpha-creatinine ratio is acute increased in pyelonephritis and it decreases after appropriate therapy with a high sensitivity for early diagnosis of the disease.	Creatinine	79-89	tumor necrosis factor	Homo sapiens	69-78
19187564-8	2009	Patients with PTH levels in the second to fourth quartiles had higher odds of prevalent MS (odds ratio 1.47 [95% CI 0.92-2.35], 2.33 [95% CI 1.40-3.87] and 2.09 [95% CI 1.23-3.56], respectively), after adjustment for 25(OH)D, magnesium, calcium, phosphate, creatinine, age, gender, season of serum sampling, BMI, current smoking, albuminuria, CRP, insulin resistance and type 2 diabetes.	Creatinine	257-267	parathyroid hormone	Homo sapiens	14-17
19119287-8	2009	Higher C-reactive protein and white blood cell count and lower serum albumin were associated with higher levels of cystatin C and lower levels of creatinine.	Creatinine	146-156	C-reactive protein	Homo sapiens	7-25
19118153-5	2009	Cyclosporin A-treated Nfatc1(+/-) mice demonstrated rapid and severe injury after administration of mercuric chloride, with increased serum creatinine, increased apoptosis, decreased PTC proliferation, and increased mortality compared with similarly treated wild-type mice.	Creatinine	140-150	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	22-28
19067655-7	2009	Linear regression analyses indicated a strong association for serum creatinine with pre-transplant CDKN2A levels ( p = 0.001) and donor age ( p = 0.004) at 6 months post-transplant.	Creatinine	68-78	cyclin dependent kinase inhibitor 2A	Homo sapiens	99-105
19067655-10	2009	Multiple linear regression analyses for CDKN2A and donor age accounted for 24.6% ( p = 0.001) of observed variability in serum creatinine levels at 6 months and 23.7% ( p = 0.001) at 1 year posttransplant.	Creatinine	127-137	cyclin dependent kinase inhibitor 2A	Homo sapiens	40-46
19236621-6	2009	Furthermore, in patients with low numbers of CD34+ cells (0.68 &gt; cells/microl, lowest quartile of CD34+ cell number) UAER increased significantly after 12 months compared with baseline [from 34.3 +/- 7.0 to 53.6 +/- 10.8 mg/g creatinine (gCr), P &lt; 0.05], whereas in patients with a high number of CD34+ cells (1.0 &lt; cells/microl, highest quartile of CD34+ cell number) UAER did not change (from 16.7 +/- 4.8 to 20.1 +/- 3.0 mg/gCr).	Creatinine	229-239	CD34 molecule	Homo sapiens	45-49
18958458-10	2009	Creatinine at first admission predicted poorer outcome in terms of worse prothrombin time, KCHC and death (p &lt; 0.001).	Creatinine	0-10	coagulation factor II, thrombin	Homo sapiens	73-84
18852688-6	2009	Levels of VE-cadherin, which were the most significantly reduced in ESRD (p = 0.001) inversely correlated in all of the patient population with serum urea and creatinine concentration, whereas among the ESRD group showed an inverse correlation with diastolic blood pressure (BP), interventricular septum thickness (IVST), and left ventricular mass index.	Creatinine	159-169	cadherin 5	Homo sapiens	10-21
19200219-8	2009	Low creatinine clearance was associated with higher plasma adiponectin (R=-0.26, p = 0.01).	Creatinine	4-14	adiponectin, C1Q and collagen domain containing	Homo sapiens	59-70
19072554-5	2009	Kinetic analysis showed that a decrease in the serum creatinine level during the acute phase of illness was often accompanied by an increase in the magnitude of IFN-gamma-producing T cells.	Creatinine	53-63	interferon gamma	Homo sapiens	161-170
18948687-8	2009	However, in linear regression, change in interleukin-6 was correlated with change in creatinine.	Creatinine	85-95	interleukin 6	Homo sapiens	41-54
19860361-0	2009	Albumin/creatinine ratio for prediction of 24-hour albumin excretion of &gt; or =2 g in manifest preeclampsia.	Creatinine	8-18	albumin	Homo sapiens	51-58
19860361-3	2009	The variation of albumin-creatinine ratios in samples across the day was analyzed by the Friedman and inter-assay coefficient variation.	Creatinine	25-35	albumin	Homo sapiens	17-24
19860361-4	2009	For each sample, receiver operator characteristic (ROC) curves were constructed to determine an optimal albumin/creatinine ratio value in the prediction of albuminuria &gt; or =2 g. RESULTS: The albumin/creatinine ratio did not vary significantly over time when all samples pooled.	Creatinine	112-122	albumin	Homo sapiens	156-163
19860361-4	2009	For each sample, receiver operator characteristic (ROC) curves were constructed to determine an optimal albumin/creatinine ratio value in the prediction of albuminuria &gt; or =2 g. RESULTS: The albumin/creatinine ratio did not vary significantly over time when all samples pooled.	Creatinine	203-213	albumin	Homo sapiens	104-111
19874577-11	2009	NSE levels were found to correlate with the change in serum creatinine in the first 24 hours both in simple and multivariate regression (both r = 0.24, P = 0.002).	Creatinine	60-70	enolase 2	Homo sapiens	0-3
18840768-4	2009	Furthermore, serum creatinine positively and GFR negatively predicted FGF21 concentrations in multiple regression analyses in control subjects (P &lt; 0.05).	Creatinine	19-29	fibroblast growth factor 21	Homo sapiens	70-75
19506322-4	2009	Systemic oxidative stress was assessed by urinary creatinine-indexed 8-epi-prostaglandin F-(2alpha) (8-epi-PGF(2alpha)).	Creatinine	50-60	placental growth factor	Homo sapiens	107-110
19007973-7	2009	Further, urinary levels of Bcl-2 were elevated in ovarian cancer patients regardless of tumor grade, stage, size, histologic subtype, creatinine levels or patient age, but appeared to complement CA125 measurements.	Creatinine	134-144	BCL2 apoptosis regulator	Homo sapiens	27-32
19377254-8	2009	Univariate analysis demonstrated that nephrotic syndrome, acute nephritic syndrome and a creatinine clearance less than 30 mL/min/1.73 m2 were all associated with a significantly increased risk of developing grades IV and/or V lesions.	Creatinine	89-99	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
18984661-5	2009	RESULTS: Multiple regression analysis adjusted for age, duration of diabetes, body mass index, and serum creatinine showed that osteocalcin negatively correlated with fasting plasma glucose and hemoglobin A(1c) in both men and postmenopausal women (P &lt; 0.05) and with percent fat, baPWV, and IMT in men (P &lt; 0.05).	Creatinine	105-115	bone gamma-carboxyglutamate protein	Homo sapiens	128-139
18987917-6	2009	MEASUREMENTS: Serum creatinine levels were used to determine eGFR from the MDRD equation.	Creatinine	20-30	epidermal growth factor receptor	Homo sapiens	61-65
19622896-5	2009	RESULTS: Despite a correlation of fetuin-A levels with creatinine clearance (r = 0.348, p &lt; 0.01) and estimated GFR (r = 0.331, p &lt; 0.01), no significant increase in fetuin-A levels over the first 3 months was observed.	Creatinine	55-65	alpha 2-HS glycoprotein	Homo sapiens	34-42
18685143-9	2009	The mRNA expression of nephrin, erzin, podocin but not synaptopodin correlated with the degree of proteinuria and creatinine clearance.	Creatinine	114-124	NPHS2 stomatin family member, podocin	Homo sapiens	39-46
19052467-5	2009	The plasma adiponectin concentration as a whole was positively correlated with serum high-density lipoprotein cholesterol and negatively with serum creatinine and waist circumference.	Creatinine	148-158	adiponectin, C1Q and collagen domain containing	Homo sapiens	11-22
19147994-5	2009	Median urinary TGF-beta1 excretion (pg/mg creatinine) was significantly higher in patient groups (manifest BEN: 203, early-stage BEN: 341, GN: 775) than in healthy controls (42).	Creatinine	42-52	transforming growth factor beta 1	Homo sapiens	15-24
19729965-8	2009	In the Cox regression model with adjustment for clinical risk factors, including age at diagnosis, hypertension, serum creatinine and urinary protein excretion at renal biopsy, AGT M235T TT variant was an independent risk factor only for male patients (hazard ratio 5.848; p = 0.005).	Creatinine	119-129	angiotensinogen	Homo sapiens	177-180
18703997-2	2009	Creatinine values in serum and urine are frequently used in children to calculate creatinine clearance (mCrCl) or estimate glomerular filtration rate (GFR) by Schwartz"s equation (eGFR).	Creatinine	0-10	epidermal growth factor receptor	Homo sapiens	180-184
19921986-8	2009	In the predialysis group, there were negative correlations between Hsp72 protein level and serum creatinine concentration, blood urea nitrogen and C-reactive protein.	Creatinine	97-107	heat shock protein family A (Hsp70) member 1A	Homo sapiens	67-72
19799193-6	2009	Urine excretion of MMP and TIMP in patients with progressive CGN directly correlated with 24-h PU and negatively correlated with blood serum creatinine.	Creatinine	141-151	TIMP metallopeptidase inhibitor 1	Homo sapiens	27-31
19768194-5	2009	In the last decade a new paradigm has been introduced in which the true or measured GFR is estimated (eGFR) by formulas based on serum creatinine levels and in which these estimates are applied to the diagnoses of chronic kidney disease (CKD) in the general population.	Creatinine	135-145	epidermal growth factor receptor	Homo sapiens	102-106
18930752-8	2008	Creatinine secretion was by OCT2-mediated uptake at the basolateral membrane and via MDR1 at the apical membrane.	Creatinine	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
19377236-4	2008	The ratios of urinary IL-8 to creatinine (IL-8/C) before and after the treatment were compared with each other.	Creatinine	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	42-48
19164257-8	2009	The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p&lt;0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358).	Creatinine	99-109	interleukin 6	Homo sapiens	50-54
18845370-9	2008	RESULTS: Of the 4,971 participants analyzed, mean creatinine-based eGFR was 81 +/- 17 (SD) mL/min/1.73 m(2) and mean eGFR(cysC) was 94 +/- 32 mL/min/1.73 m(2).	Creatinine	50-60	epidermal growth factor receptor	Homo sapiens	67-71
18796544-6	2008	The upregulated expressions of UII and GPR14 in the kidney were accompanied by significant increases in the renal profibrotic factor transforming growth factor (TGF)-beta1 expression, the renal extracellular matrix (fibronectin and collagen IV) accumulation, and the renal dysfunction (increases in urinal N-acetyl-beta-d-glucosaminidase content, 24-h urinary retinol-binding protein excretion rate, and decrease in creatinine clearance rate).	Creatinine	416-426	urotensin 2	Rattus norvegicus	31-34
18489524-5	2008	RESULTS: The mean (sem) urinary NGF/Cr levels were low both in controls, at 0.06 (0.004) and in women with pure USI, at 0.056 (0.037) (P = 0.108).	Creatinine	36-38	nerve growth factor	Homo sapiens	32-35
18489524-8	2008	A urinary NGF/Cr level of &gt;0.05 was found in 9% of women with USI, 77% with DO, 81% with mixed USI and DO, and 80% with de novo DO.	Creatinine	14-16	nerve growth factor	Homo sapiens	10-13
19106513-5	2008	Eleven days following the administration of docetaxel: 30 mg/m2 and nedaplatin: 30 mg/m2, the patient developed TLS (serum creatinine: 8.57 mg/dL, uric acid: 11.0 mg/dL, serum potassium: 6.3 mEq/L, serum phosphorus: 7.18 mg/dL).	Creatinine	123-133	FUS RNA binding protein	Homo sapiens	112-115
18567692-7	2008	Univariate analysis revealed that (1) a higher SRL level at 1 month was a predictor of SRL withdrawal due to severe side effects (P = 0.006), and (2) predictors of graft failure after SRL conversion were low SRL loading dose (P = 0.03) and a higher creatinine level at conversion (P = 0.003).	Creatinine	249-259	sarcalumenin	Homo sapiens	47-50
18772341-8	2008	Administering C5aR siRNA to mice preserved renal function from I/R injury, as evidenced by reduced levels of serum creatinine and blood urea nitrogen in the treated groups.	Creatinine	115-125	complement component 5a receptor 1	Mus musculus	14-18
18683214-5	2008	RESULTS: Higher TNF-alpha levels were found to correlate with poorer performance status; higher leukocyte counts; higher levels of beta2-microglobulin, creatinine, uric acid, and alkaline phosphatase; lower levels of creatinine clearance and albumin; baseline infection; and M4-M5 AML subtypes.	Creatinine	152-162	tumor necrosis factor	Homo sapiens	16-25
18683214-5	2008	RESULTS: Higher TNF-alpha levels were found to correlate with poorer performance status; higher leukocyte counts; higher levels of beta2-microglobulin, creatinine, uric acid, and alkaline phosphatase; lower levels of creatinine clearance and albumin; baseline infection; and M4-M5 AML subtypes.	Creatinine	217-227	tumor necrosis factor	Homo sapiens	16-25
18775113-6	2008	Changes in the serum creatinine concentration and hyperkalemia are complications of antihypertensive therapy in patients with chronic kidney disease that can be successfully managed to allow continued use of renin-angiotensin blockade.	Creatinine	21-31	renin	Homo sapiens	208-213
18830196-7	2008	CONCLUSIONS: It is imperative to screen for FHH using 24-hour urinary calcium and creatinine excretion in subjects with hypercalcemia irrespective of ethnicity and a history of non-traumatic rib fractures.	Creatinine	82-92	calcium sensing receptor	Homo sapiens	44-47
18581145-8	2008	U(NAG) and U(NAG) to creatinine ratio (U(NAG/CR)) were elevated in all patients with thalassemia compared with the control group (p &lt; 0.001) and were directly correlated to the amount of transfused iron but not to actual ferritin level.	Creatinine	21-31	N-acetyl-alpha-glucosaminidase	Homo sapiens	13-16
18581145-8	2008	U(NAG) and U(NAG) to creatinine ratio (U(NAG/CR)) were elevated in all patients with thalassemia compared with the control group (p &lt; 0.001) and were directly correlated to the amount of transfused iron but not to actual ferritin level.	Creatinine	21-31	N-acetyl-alpha-glucosaminidase	Homo sapiens	13-16
18791679-8	2008	Plasma HcyT concentrations were positively correlated with urinary excretion of albumin/creatinine (Alb/Cr; r=0.285, P=0.007), duration of diabetes (r=0.249, P=0.019), age (r=0.233, P=0.028), and fibrinogen levels (r=0.289, P=0.034).	Creatinine	88-98	albumin	Homo sapiens	100-103
18593765-8	2008	After controlling for matching factors, adjustment for waist to hip ratio, hypertension, smoking, alcohol, low-density lipoprotein cholesterol, creatinine, and leptin revealed a modestly increased risk of incident CHD with adiponectin concentrations at the upper end [odds ratio = 1.37 (quintile 5 vs. 1-4), 95% confidence interval 1.02-1.84].	Creatinine	144-154	adiponectin, C1Q and collagen domain containing	Homo sapiens	223-234
18781900-7	2008	The clinical diagnosis was not a predictive independent variable, however ABCB1 genotypes C1236T, G2677T/A, age and creatinine level showed to be related to Abeta peak intensities in multivariate analyses.	Creatinine	116-126	ATP binding cassette subfamily B member 1	Homo sapiens	74-79
18949730-8	2008	There was also a positive trend between plasma adiponectin levels and the ratios of dialysate to plasma creatinine concentration (D/P Cr).	Creatinine	104-114	adiponectin, C1Q and collagen domain containing	Homo sapiens	47-58
18725957-6	2008	Herein, B1R antagonism (R-954) was able to decrease serum creatinine levels, whereas B2R antagonism had no effect.	Creatinine	58-68	bradykinin receptor, beta 1	Mus musculus	8-11
18788389-3	2008	Second is eGFR less than 60 mL/min calculated by the equation using serum creatinine.	Creatinine	74-84	epidermal growth factor receptor	Homo sapiens	10-14
18698241-11	2008	Creatinine excretion was associated with both mortality (3rd vs. 1st tertile Hazard ratio: 0.4 [95% confidence interval 0.2-0.7], P=0.003) and graft loss (3rd vs. 1st tertile Hazard ratio: 0.4 [95% confidence interval 0.1-0.9], P=0.03) independent of age, sex, serum creatinine, proteinuria, insulin resistance related factors, time after transplantation, and duration of dialysis.	Creatinine	0-10	insulin	Homo sapiens	292-299
18645056-7	2008	Higher TNFalpha was associated with decreased creatinine clearance, nonsmoking status, anemia, and greater comorbidity (P(trend)&lt;0.05 for all).	Creatinine	46-56	tumor necrosis factor	Homo sapiens	7-15
18307573-7	2008	RESULTS: The average serum creatinine clearance in our group was 132.84 ml/min/1.73 m(2) (46.8-510).	Creatinine	27-37	CD59 molecule (CD59 blood group)	Homo sapiens	75-80
18462273-5	2008	A multiple linear regression analysis revealed that the combination of CDKN2A values and donor age yielded even higher predictive values for serum creatinine 1 year after transplantation.	Creatinine	147-157	cyclin dependent kinase inhibitor 2A	Homo sapiens	71-77
18651543-5	2008	RESULTS: Levels of VEGF in serum (126.96 +/- 20.13 pg/mL; 95% confidence interval [95% CI], 83.10-170.83) and urine (16.14 +/- 4.09 ng/mmol creatinine; 95% CI, 7.21-25.06) of 13 patients with subclinical rejection significantly differed from those of 119 patients with no allograft rejection (No-AR) and health controls.	Creatinine	140-150	vascular endothelial growth factor A	Homo sapiens	19-23
19115622-7	2008	But the polymorphism of Rsa I / Pst I site of CYP2E1 5"-franking region was not correlated with the concentration of urine formic acid (chi2 = 4.285, P=0.117), and the urinary formic acid means of subjects with C1/C1, C1/C2, C2/C2 genotype were (11.14 +/- 7.91), (12.13 +/- 8.16) and (16.51 -/+ 3.78) mg/g creatinine, respectively.	Creatinine	306-316	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
18958182-5	2008	Plasma AGT levels showed a normal distribution; however, urinary AGT-creatinine ratios (UAGT/UCre) deviated from the normal distribution.	Creatinine	69-79	angiotensinogen	Homo sapiens	65-68
18651543-7	2008	Levels of VEGF in serum and urine after antirejection therapy (50.45 +/- 6.58 pg/mL and 2.60 +/- 0.83 ng/mmol creatinine, respectively) were lower than those at the time of protocol biopsy.	Creatinine	110-120	vascular endothelial growth factor A	Homo sapiens	10-14
18368027-6	2008	The area of either CD68 or DC-SIGN positive interstitial cells correlated with serum creatinine.	Creatinine	85-95	CD209 molecule	Homo sapiens	27-34
18591313-8	2008	In contrast, urinary levels of TNF-alpha were significantly decreased in the women with preeclampsia compared with the healthy women (median [interquartile range], preeclampsia: 0.26 [0.10-0.91] versus control: 0.58 [0.21-1.29] pg/mg creatinine, P=.003), even though the hypertensive women had higher levels of proteinuria.	Creatinine	234-244	tumor necrosis factor	Homo sapiens	31-40
18400272-6	2008	The total urinary NGF levels were normalized to the concentration of the urinary creatinine (NGF/Cr) level.	Creatinine	81-91	nerve growth factor	Homo sapiens	93-96
18455421-0	2008	Oxidative stress, phosphate and creatinine levels are independently associated with vascular endothelial growth factor levels in patients with chronic renal failure.	Creatinine	32-42	vascular endothelial growth factor A	Homo sapiens	84-118
18455421-4	2008	The strong positive associations were between VEGF and creatinine, urea, phosphate and CaxP product (all p&lt;0.0001), Cu/Zn SOD (p&lt;0.001) and hs CRP levels (p&lt;0.01).	Creatinine	55-65	vascular endothelial growth factor A	Homo sapiens	46-50
18455421-6	2008	In multiple regression analysis increased Cu/Zn SOD, phosphate and creatinine levels were found to be independent factors affecting VEGF.	Creatinine	67-77	vascular endothelial growth factor A	Homo sapiens	132-136
18298587-4	2008	Patients with increased creatinine had less frequently detectable CD3+CD4+CD25+IFN-gamma+ PBL than patients with good graft function (P = 0.017).	Creatinine	24-34	CD4 molecule	Homo sapiens	70-73
18298587-4	2008	Patients with increased creatinine had less frequently detectable CD3+CD4+CD25+IFN-gamma+ PBL than patients with good graft function (P = 0.017).	Creatinine	24-34	interferon gamma	Homo sapiens	79-88
18419255-4	2008	The CD61 intensity at the oliguric phase was inversely correlated with platelet count and serum albumin, and positively correlated with white blood cell count, blood urea nitrogen, serum creatinine, and alanine aminotransferase levels.	Creatinine	187-197	integrin subunit beta 3	Homo sapiens	4-8
18285417-10	2008	Finally, change in the PYR/Cr ratio was positively associated baseline IL-6, hs-CRP, and their changes (all P &lt; 0.05) in women, but not men.	Creatinine	27-29	interleukin 6	Homo sapiens	71-75
18285417-10	2008	Finally, change in the PYR/Cr ratio was positively associated baseline IL-6, hs-CRP, and their changes (all P &lt; 0.05) in women, but not men.	Creatinine	27-29	C-reactive protein	Homo sapiens	80-83
18433034-8	2008	Patients with pretransplant kidney dysfunction &gt; 12 weeks were at increased risk for eGFR &lt; 20 mL/minute (hazard ratio = 5.3, P = 0.04), a risk that escalated after adjustment for age and serum creatinine at transplant (hazard ratio = 8.9, P = 0.01).	Creatinine	200-210	epidermal growth factor receptor	Homo sapiens	88-92
18433034-9	2008	Significant predictors of eGFR &lt; 20 mL/minute post-OLTa in this patient cohort were the presence of diabetes and the serum creatinine level at transplant.	Creatinine	126-136	epidermal growth factor receptor	Homo sapiens	26-30
18431264-12	2008	The mean serum concentrations of creatinine and blood urea nitrogen were significantly (p &lt; .05) lower in the hANP group than in the placebo group.	Creatinine	33-43	natriuretic peptide A	Homo sapiens	113-117
18426835-10	2008	After controlling for age, gender, co-morbidity and creatinine, the prognostic impact of elevated serum PTH was still significant (HR=1.24, 95% CI: 1.01-1.53).	Creatinine	52-62	parathyroid hormone	Homo sapiens	104-107
18343723-5	2008	RESULTS: After adjustment for age, sex and creatinine, levels of TIMP-1 (1640 vs. 735 ng/ml, P&lt;0.001) but not MMP-9 were elevated in CHF patients compared to controls.	Creatinine	43-53	TIMP metallopeptidase inhibitor 1	Homo sapiens	65-71
18284535-10	2008	At the 4-year follow-up, the magnitude of declines of the above four renal parameters was significantly higher in subjects with the ACE D allele than in the non-D-allele carriers (P = .01, .01, .04, and .01 for creatinine, CG CrCl, Jelliffe CrCl, and MDRD GFR, respectively).	Creatinine	211-221	angiotensin I converting enzyme	Homo sapiens	132-135
27408108-5	2008	The mean measured creatinine clearance was 87.15 ml/min/1.73m(2), SD +- 20.5 (range 56.9-137 ml/min/1.73m(2)).	Creatinine	18-28	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
27408108-6	2008	In 25 (50%) patients, one hour urinary creatinine clearance was &lt;80 ml/min/1.73m(2) and in two (4%) patients, the creatinine clearance was &lt;60 ml/min/1.73m(2).	Creatinine	39-49	CD59 molecule (CD59 blood group)	Homo sapiens	74-79
27408108-8	2008	The differences between the predictive equations and creatinine clearance, as illustrated by the +-95% confidence interval in the Bland-Altman graphs was very significant [Cockcroft- Gault = -40.3 to 17.7 ml/min/ 1.73m(2), Modification of Diet in Renal Disease equation = -46.2 to 30.6 ml/min/1.73m(2) and the simplified Modification of Diet in Renal Disease equation = -72.8 to 24.8 ml/min/1.73m(2)].	Creatinine	53-63	CD59 molecule (CD59 blood group)	Homo sapiens	289-294
27408108-8	2008	The differences between the predictive equations and creatinine clearance, as illustrated by the +-95% confidence interval in the Bland-Altman graphs was very significant [Cockcroft- Gault = -40.3 to 17.7 ml/min/ 1.73m(2), Modification of Diet in Renal Disease equation = -46.2 to 30.6 ml/min/1.73m(2) and the simplified Modification of Diet in Renal Disease equation = -72.8 to 24.8 ml/min/1.73m(2)].	Creatinine	53-63	CD59 molecule (CD59 blood group)	Homo sapiens	387-392
18578690-1	2008	BACKGROUND: The accuracy of estimating glomerular filtration rate from plasma creatinine (eGFR) has been questioned but it is unclear how much covert error in several reference methods that have been used has contributed to this perceived inaccuracy.	Creatinine	78-88	epidermal growth factor receptor	Homo sapiens	90-94
18371537-10	2008	ACE/ACE2 ratio correlated positively with values for mean blood pressure, fasting blood glucose, serum creatinine, proteinuria, and hemoglobin A(1c) and inversely with estimated glomerular filtration rate (P < 0.001).	Creatinine	103-113	angiotensin I converting enzyme	Homo sapiens	0-3
18317874-6	2008	Serum CRP levels were measured in 21 patients with a malignancy and 28 patients with a non-malignancy whose creatinine clearance (Ccr) was &gt; or =70 ml/min.	Creatinine	108-118	C-reactive protein	Homo sapiens	6-9
18282491-6	2008	Similarly, NGF levels were higher in PDR patients than in controls and NPDR patients after adjusting for possible confounding factors such as age, gender, serum blood urea nitrogen, creatinine, and diabetic parameters.	Creatinine	182-192	nerve growth factor	Homo sapiens	11-14
18431264-13	2008	The mean urine volume and mean creatinine clearance were significantly (p &lt; .05) higher in the hANP group than in the placebo group.	Creatinine	31-41	natriuretic peptide A	Homo sapiens	98-102
18431264-14	2008	The mean urinary NAG/creatinine ratio was significantly (p &lt; .05) lower in the hANP group than in the placebo group.	Creatinine	21-31	natriuretic peptide A	Homo sapiens	82-86
18293167-10	2008	In further multivariate regression analysis, only in men, TGF-beta1 and TGF-beta3 genotypes as independent predictors had statistically significant effect on serum creatinine (p = 0.007) and urinary albumin excretion (p = 0.022), respectively.	Creatinine	164-174	transforming growth factor beta 1	Homo sapiens	58-67
18160471-10	2008	The levels of microalbuminuria related to creatinine were directly correlated with fasting glucose levels (r=0.27; P=0.0019), fasting insulin levels (r=0.28; P=0.017), and insulin after 90 (r=0.26; P=0.027) and 120 min after glucose load (r=0.26; P=0.023) and indirectly correlated with ISI composite (P&lt;0.0001; r=-0.48).	Creatinine	42-52	insulin	Homo sapiens	134-141
18160471-10	2008	The levels of microalbuminuria related to creatinine were directly correlated with fasting glucose levels (r=0.27; P=0.0019), fasting insulin levels (r=0.28; P=0.017), and insulin after 90 (r=0.26; P=0.027) and 120 min after glucose load (r=0.26; P=0.023) and indirectly correlated with ISI composite (P&lt;0.0001; r=-0.48).	Creatinine	42-52	insulin	Homo sapiens	172-179
18068386-10	2008	Among people with an abnormal albumin/creatinine ratio (11%), 59% received an ACE inhibitor/ARB.	Creatinine	38-48	angiotensin I converting enzyme	Homo sapiens	78-81
18226042-10	2008	Independent correlates of MPO level were acute coronary syndrome (P &lt; 0.001), high-sensitivity C-reactive protein (P = 0.007), creatinine (P = 0.026), left ventricular ejection fraction (P = 0.027, negative association) and smoking (P = 0.028).	Creatinine	130-140	myeloperoxidase	Homo sapiens	26-29
18230826-7	2008	HMW adiponectin and total adiponectin correlated positively with creatinine and negatively with fasting insulin in univariate and multivariate analyses.	Creatinine	65-75	adiponectin, C1Q and collagen domain containing	Homo sapiens	4-15
18230826-7	2008	HMW adiponectin and total adiponectin correlated positively with creatinine and negatively with fasting insulin in univariate and multivariate analyses.	Creatinine	65-75	adiponectin, C1Q and collagen domain containing	Homo sapiens	26-37
18234553-7	2008	MMP-3 was associated with patient age (p&lt;0.001), creatinine (p&lt;0.001) and was higher in males (p&lt;0.001) and hypertensives (p&lt;0.001).	Creatinine	52-62	matrix metallopeptidase 3	Homo sapiens	0-5
18094680-4	2008	Enzyme-linked immunosorbent assay analysis showed increased L-FABP levels (factored for creatinine excretion) of about 94- and 45-fold at 4 and 12 h, respectively, following surgery in the 21 patients who developed AKI with western blot analysis, confirming L-FABP identity.	Creatinine	88-98	fatty acid binding protein 1	Homo sapiens	60-66
18275445-10	2008	Significant differences (p &lt; 0.0002) were noted by gender in all three variables in the CART model (blood urea nitrogen [BUN] &gt; or = 43 mg/dL, systolic blood pressure &lt; 115 mm Hg, and serum creatinine &gt; or = 2.75 mg/dL).	Creatinine	199-209	CART prepropeptide	Homo sapiens	91-95
18219370-2	2008	The use of MDRD-eGFR to diagnose Chronic Kidney Disease (CKD) is based on the assumption that the algorithm will minimize the influence of age, gender and ethnicity that is observed in S-Creatinine concentration and thus allow a single cut-off at which further diagnostic and therapeutic actions should be considered.	Creatinine	187-197	epidermal growth factor receptor	Homo sapiens	16-20
18219370-8	2008	The gender and age differences of the S-Creatinine concentrations in the dataset persist after applying the MDRD-eGFR algorithm.	Creatinine	40-50	epidermal growth factor receptor	Homo sapiens	113-117
18405027-6	2008	Initial serum creatinine levels were correlated with RBF and IL-2 levels during nephrectomy (R = 0.831, R2 = 0.691, p = 0.025), and postransplantation RBF (R = 0.784, R2 = 0.614, p &lt; 0.0001).	Creatinine	14-24	interleukin 2	Homo sapiens	61-65
18405027-7	2008	Seventh day creatinine levels were correlated with postransplantation RBF (R = 0.537, R2 = 0.289, p = 0.002) and IL-2 levels during nephrectomy (R = 0.685, R2 = 0.469, p = 0.015).	Creatinine	12-22	interleukin 2	Homo sapiens	113-117
18573197-8	2008	Duration of RA and CRP levels were independently associated with NT-proBNP in the final model that was adjusted for gender, age, and creatinine levels (r2 adjusted = 0.38; P &lt; 0.001).	Creatinine	133-143	C-reactive protein	Homo sapiens	19-22
18298343-1	2008	Accurate serum creatinine measurements in glomerular filtration rate estimation (eGFR) using equations are critical to ongoing global public health efforts to improve the diagnosis and treatment of chronic kidney disease.	Creatinine	15-25	epidermal growth factor receptor	Homo sapiens	81-85
18298343-5	2008	Thus, analytical non-specificity for substances found in individual patient samples can affect the accuracy of eGFR computed from serum creatinine values for any alkaline picrate method, including the so-called "compensated" Jaffe methods.	Creatinine	136-146	epidermal growth factor receptor	Homo sapiens	111-115
18298343-6	2008	The use of assays that are more specific for serum creatinine determination, such as those based on enzymatic reactions, may provide more reliable eGFR values.	Creatinine	51-61	epidermal growth factor receptor	Homo sapiens	147-151
18758126-10	2008	In the univariate analysis, serum levels of VEGF, were positively correlated with systolic blood pressure (R: 0.253 p: 0.001), diastolic blood pressure (R: 0.162 p: 0.04), mean arterial pressure (R: 0.239 p: 0.002), creatinine clearance (R: 0.172 p: 0.04) and MAU (R: 0.338 p: 0.002).	Creatinine	216-226	vascular endothelial growth factor A	Homo sapiens	44-48
18497502-8	2008	In this study, CKD was defined as &lt;60 ml/min/1.73 m(2) of estimated creatinine clearance by the Cockcroft-Gault method.	Creatinine	71-81	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
19432175-7	2008	The regression analysis showed that among various parameters (increase level of protein in urine, urea, creatinine, IL-6 and von Willebrand factor in blood, heart contraction rate), the growth of level of myeloperoxidase accompanied by activity reduction of glutathione reductase in neutrophils has also been connected with the increase of lethal outcome risk.	Creatinine	104-114	myeloperoxidase	Homo sapiens	205-220
17932247-3	2008	A more than 2-fold increase in CD11b-positive macrophages in the kidney on day 2 preceded the increase in blood urea nitrogen (BUN) and serum creatinine (SCr).	Creatinine	142-152	integrin alpha M	Mus musculus	31-36
18721492-12	2008	We found a statistically significant negative correlation between adiponectin and creatinine (r=-0.26; p=0.011).	Creatinine	82-92	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
18199108-3	2008	RESULTS: Subjects with acute rejection (n=67) excreted urinary VEGF at a significantly higher level (28.57+/-6.21, 95% CI: 16.18-40.97 pg/mumol creatinine) than those without acute rejection.	Creatinine	144-154	vascular endothelial growth factor A	Homo sapiens	63-67
18199108-6	2008	Patients with steroid-resistant acute rejection had significantly greater urinary VEGF concentration than patients with steroid-sensitive acute rejection (42.09+/-10.00 vs 9.74+/-2.63 pg/micromol creatinine, P&lt;0.001).	Creatinine	196-206	vascular endothelial growth factor A	Homo sapiens	82-86
18199108-7	2008	Patients with graft loss after acute rejection had significantly greater urinary VEGF concentration than patients with reversible acute rejection (106.66+/-38.60 vs 19.46+/-4.13 pg/micromol creatinine, P=0.001).	Creatinine	190-200	vascular endothelial growth factor A	Homo sapiens	81-85
18721492-17	2008	Adiponectin level correlated negatively with creatinine level end microalbuminuria.	Creatinine	45-55	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
18569927-3	2008	The postoperative ARF definition was based on the creatinine increase by the RIFLE classification (R = risk, I = injury, F = failure, L = loss, E = end stage), which corresponds to a 1.5 creatinine increase, two to three times, respectively, above the basal value.	Creatinine	50-60	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	77-82
18569963-3	2008	In a retrospective study of S-Creatinine concentrations from laboratory information systems of hospitals in the UK and Sweden, comprising about 140,000 results in total, it was found that the MDRD-eGFR indeed differs between genders and that it varies with age more than the S-Creatinine concentration does.	Creatinine	30-40	epidermal growth factor receptor	Homo sapiens	197-201
18569963-3	2008	In a retrospective study of S-Creatinine concentrations from laboratory information systems of hospitals in the UK and Sweden, comprising about 140,000 results in total, it was found that the MDRD-eGFR indeed differs between genders and that it varies with age more than the S-Creatinine concentration does.	Creatinine	277-287	epidermal growth factor receptor	Homo sapiens	197-201
18609082-9	2008	CONCLUSION: The weaker association observed between CRP and creatinine-based measures, as compared to cystatin C, reflects the misclassification of elderly frail subjects as having normal kidney function rather than suggests cystatin C itself to be a marker of inflammation.	Creatinine	60-70	C-reactive protein	Homo sapiens	52-55
17898039-13	2007	Urinary MMP-2 and TIMP-1 levels showed a positive correlation with tubulointerstitial damage and a negative correlation with creatinine clearance.	Creatinine	125-135	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-24
17898039-15	2007	However, urinary MMP-2 activity and TIMP-1 levels reflect tubulointerstitial damage and correlate negatively with creatinine clearance at biopsy.	Creatinine	114-124	TIMP metallopeptidase inhibitor 1	Homo sapiens	36-42
18075240-8	2007	Patients with high CRP levels (&gt; or = 5 mg/dl) during the first week after admission showed a significantly greater elevation of serum creatinine levels as compared to the levels before admission than those with low CRP levels (&lt; 5 mg/dl).	Creatinine	138-148	C-reactive protein	Homo sapiens	19-22
17954367-6	2007	RESULTS: Urinary levels of L-FABP and 8-OHdG were higher in patients with IgA nephropathy than in age-matched and sex-matched healthy controls (122.5 +/- 25.5 v 6.4 +/- 3.8 mug/g.creatinine, P &lt; .001; and 22.6 +/- 4.4 v 4.8 +/- 1.4 ng/mg.creatinine, P &lt; .01, respectively).	Creatinine	179-189	fatty acid binding protein 1	Homo sapiens	27-33
17954367-6	2007	RESULTS: Urinary levels of L-FABP and 8-OHdG were higher in patients with IgA nephropathy than in age-matched and sex-matched healthy controls (122.5 +/- 25.5 v 6.4 +/- 3.8 mug/g.creatinine, P &lt; .001; and 22.6 +/- 4.4 v 4.8 +/- 1.4 ng/mg.creatinine, P &lt; .01, respectively).	Creatinine	241-251	fatty acid binding protein 1	Homo sapiens	27-33
18924523-1	2008	UNLABELLED: Glomerular filtration rate (eGFR) calculated from serum creatinine can be overestimated in patients with muscle mass deficits.	Creatinine	68-78	epidermal growth factor receptor	Homo sapiens	40-44
18924523-2	2008	AIM: The aim of this study was to compare eGFR calculated from serum levels of creatinine and cystatin C in a group of patients with neurogenic bladder due to MMC.	Creatinine	79-89	epidermal growth factor receptor	Homo sapiens	42-46
18197546-13	2008	Two patients exhibited very steep serum creatinine trajectories, indicative of rapid loss of eGFR.	Creatinine	40-50	epidermal growth factor receptor	Homo sapiens	93-97
17908272-9	2007	Mean serum creatinine was 1.1 +/- 0.6 mg/dL, and calculated creatinine clearance was 82.3 +/- 29.4 mL/min/1.73 m(2).	Creatinine	60-70	CD59 molecule (CD59 blood group)	Homo sapiens	102-107
17898699-4	2007	Repeated intravenous doses of cationized catalase significantly decreased cisplatin-induced changes in serum creatinine, blood urea nitrogen, nitrite/nitrate levels, lactic dehydrogenase activity, and renal total glutathione and malondialdehyde contents.	Creatinine	109-119	catalase	Mus musculus	41-49
18356783-9	2007	Creatinine clearance was less in the LR (7.67 +/- 3.86 ml/min/1.73 m2) vs. the ER group (8.70 +/- 3.62 ml/min/1.73 m2), but not significantly different.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
18569927-3	2008	The postoperative ARF definition was based on the creatinine increase by the RIFLE classification (R = risk, I = injury, F = failure, L = loss, E = end stage), which corresponds to a 1.5 creatinine increase, two to three times, respectively, above the basal value.	Creatinine	187-197	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	77-82
18027324-5	2007	METHODS: Insulin dosage of 68 patients treated with human insulin and 74 patients treated with analogue insulin was related to the creatinine clearance (calculated with the Cockcroft-Gault formula).	Creatinine	131-141	insulin	Homo sapiens	9-16
18080921-10	2007	In the cirrhotic group, insulin like growth factor- 1 level was positively correlated with serum albumin and negatively correlated with serum creatinine and sodium levels and spleen size.	Creatinine	142-152	insulin like growth factor 1	Homo sapiens	24-53
17761751-14	2007	(1.73 m(2))(-1) = 1.678 x BTP(-0.758) x creatinine(-0.204) x (0.871 if female).	Creatinine	40-50	prostaglandin D2 synthase	Homo sapiens	26-29
18160765-11	2007	In hypertensive patients, TGF-beta1 levels correlated with body mass index (r = 0.296, P = 0.01) and creatinine clearance (r = 0.238, P = 0.04).	Creatinine	101-111	transforming growth factor beta 1	Homo sapiens	26-35
18160765-13	2007	In addition, TGF-beta1 is positively correlated with body mass index and creatinine clearance in patients with essential hypertension.	Creatinine	73-83	transforming growth factor beta 1	Homo sapiens	13-22
18022082-13	2007	The low threshold for creatinine clearance appears to be 50 ml/min/1.73 m(2).	Creatinine	22-32	CD59 molecule (CD59 blood group)	Homo sapiens	63-68
18050145-5	2007	In this analysis, serum CRP and microalbuminuria maintained a significant association with serum creatinine, while the hemodynamic response to ACh lost substantial predictive value for serum creatinine.	Creatinine	97-107	C-reactive protein	Homo sapiens	24-27
18167241-6	2007	eGFR = 186.3 x serum creatinine(-1.154) x age(-0.203) x (0.742 for women) ml.min(-1).	Creatinine	21-31	epidermal growth factor receptor	Homo sapiens	0-4
18027324-5	2007	METHODS: Insulin dosage of 68 patients treated with human insulin and 74 patients treated with analogue insulin was related to the creatinine clearance (calculated with the Cockcroft-Gault formula).	Creatinine	131-141	insulin	Homo sapiens	58-65
18027324-5	2007	METHODS: Insulin dosage of 68 patients treated with human insulin and 74 patients treated with analogue insulin was related to the creatinine clearance (calculated with the Cockcroft-Gault formula).	Creatinine	131-141	insulin	Homo sapiens	104-111
18027324-8	2007	In analogue-treated patients, insulin dosage significantly decreased with reduced creatinine clearance (r = 0,257; p = 0,026) in contrast to human insulin treated patients who did not show such a decrease (r = 0,159; p = 0,165).	Creatinine	82-92	insulin	Homo sapiens	30-37
17490776-7	2007	Serum adiponectin positively correlated with serum creatinine and negatively correlated with 1/creatinine.	Creatinine	51-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
17903694-10	2007	Creatinine clearance also interacted with the relationship between the ACE I/D polymorphism and LVH (beta, 0.12; P = .037), although less strongly, and the other way around.	Creatinine	0-10	angiotensin I converting enzyme	Homo sapiens	71-74
17586736-6	2007	RESULTS: Across 8-epi-PGF2alpha/creatinine tertiles, the prevalence of insulin resistance increased (18.0, 27.5, and 29.4% for the first, second, and third tertiles, respectively; P &lt; 0.0001), as did mean levels of HOMA-IR (3.28, 3.83, and 4.06 units; P &lt; 0.0001).	Creatinine	32-42	insulin	Homo sapiens	71-78
17969688-3	2007	To address this issue, volatile DBP formation resulting from the chlorination of four model compounds (creatinine, urea, L-histidine, and L-arginine) was investigated over a range of chlorine/precursor (Cl/P) molar ratios.	Creatinine	103-113	D-box binding PAR bZIP transcription factor	Homo sapiens	32-35
17490776-7	2007	Serum adiponectin positively correlated with serum creatinine and negatively correlated with 1/creatinine.	Creatinine	95-105	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
17721027-7	2007	Both the multivariate regression and multiple logistic regression analyses indicated that serum H-FABP levels were independently affected by age, body mass index, creatinine clearance, and ECG abnormality score.	Creatinine	163-173	fatty acid binding protein 3	Homo sapiens	96-102
17853945-9	2007	TLR4(-/-) mice engrafted with WT hematopoietic cells had significantly lower serum creatinine and less tubular damage than WT mice reconstituted with TLR4(-/-) BM, suggesting that TLR4 signaling in intrinsic kidney cells plays the dominant role in mediating kidney damage.	Creatinine	83-93	toll-like receptor 4	Mus musculus	0-4
17702734-12	2007	After adjustment for age, gender, creatinine clearance, urine sulfate, and body mass index, a significant inverse relationship was noted between 24-h urine pH and the degree of insulin resistance.	Creatinine	34-44	insulin	Homo sapiens	177-184
18035185-11	2007	In hypertensive patients with type 2 diabetes and microalbuminuria, combination ACE-inhibitor/ARB therapy resulted in better BP control than either agent alone (mean difference, 11.2 mm Hg systolic [P = 0.002], 5.9 mm Hg diastolic [P = 0.003]), as well as greater reductions in microalbuminuria (mean difference in albumin:creatinine ratio, 34%; P = 0.04).	Creatinine	323-333	angiotensin I converting enzyme	Homo sapiens	80-83
17855830-12	2007	DARC-/- mice exhibited no renal dysfunction (renal ischemia-reperfusion) or only very mild renal dysfunction (lipopolysaccharide, 20% increase in serum creatinine concentrations).	Creatinine	152-162	atypical chemokine receptor 1 (Duffy blood group)	Mus musculus	0-4
17889105-11	2007	A significant relationship with PARP-1 expression was demonstrated with renal function (effective diuresis, serum creatinine levels) and pretransplant cold ischemia time (P &lt; .001).	Creatinine	114-124	poly(ADP-ribose) polymerase 1	Homo sapiens	32-38
17875963-6	2007	Although hemodialysis was performed 9 times and the urine output was satisfactory, the creatinine clearance levels increased only to about 50 mL/min/1.73 m2 (0.84 mL/s/m2) at 6 weeks following admission.	Creatinine	87-97	CD59 molecule (CD59 blood group)	Homo sapiens	145-150
17259649-12	2007	The dosage of insulin requirement correlates with the small solute transport of the peritoneal membrane, as represented by the mass transfer area coefficient (MTAC) of creatinine (r = -0.307, P = 0.017) and haemoglobin level (r = 0.284, P = 0.028), but not with body mass index (BMI).	Creatinine	168-178	insulin	Homo sapiens	14-21
17363678-9	2007	In all subjects (n = 29), adiponectin mRNA was related (P &lt; 0.05) negatively with TBARS after adjusting for plasma C-reactive protein (CRP) or CRP and creatinine.	Creatinine	154-164	adiponectin, C1Q and collagen domain containing	Homo sapiens	26-37
17699488-6	2007	In patients with primary aldosteronism, plasma active renin levels that were higher than the lower limit of detection (2.5 pg/ml) were associated with higher BP, plasma potassium, and albuminuria and lower creatinine clearance.	Creatinine	206-216	renin	Homo sapiens	54-59
17699488-8	2007	Creatinine clearance was correlated directly with plasma aldosterone and inversely with renin.	Creatinine	0-10	renin	Homo sapiens	88-93
18409824-5	2007	Median concentration of 1-NAF was 6-fold higher in smokers compared to nonsmokers (respectively, 7.7 microg/g creatinine vs 1.3 microg/g creatinine).	Creatinine	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
18409824-5	2007	Median concentration of 1-NAF was 6-fold higher in smokers compared to nonsmokers (respectively, 7.7 microg/g creatinine vs 1.3 microg/g creatinine).	Creatinine	137-147	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
17396112-6	2007	Chimeras with kidneys of TNF-alpha knockout mice showed significantly less renal dysfunction (blood urea nitrogen, serum creatinine, and glomerular filtration rate), renal histologic injury, and serum TNF-alpha levels; again regardless of the immune cell source.	Creatinine	121-131	tumor necrosis factor	Mus musculus	25-34
17572253-5	2007	Plasma MPO levels were predictive of long-term clinical outcomes (risk ratio [95% confidence interval] = 3.35 [1.52 to 8.86]), even after adjustment for age, LV ejection fraction, plasma B-type natriuretic peptide (BNP), creatinine clearance, or diastolic stage.	Creatinine	221-231	myeloperoxidase	Homo sapiens	7-10
17511849-7	2007	Both male gender (P = 0.002) and plasma creatinine (P = 0.009) were independently associated with the albumin ratio when controlling for putative confounders.	Creatinine	40-50	albumin	Homo sapiens	102-109
17039356-16	2007	Selective iNOS inhibition by L-NIL prevented the GM-induced decrease in GFR and increase in creatinine levels, while complete non-selective NOS inhibition by L-NAME aggravated the GFR reduction, elevation of creatinine levels and enzyme release (P &lt; 0.05).	Creatinine	92-102	nitric oxide synthase 2	Rattus norvegicus	10-14
17825709-6	2007	RESULTS: Prophylactic hemodialysis lessened the decrease in creatinine clearance within 72 h in the dialysis group (0.4 +/- 0.9 ml/min/1.73 m(2) vs. 2.2 +/- 2.8 ml/min/1.73 m(2); p &lt; 0.001).	Creatinine	60-70	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
17600656-15	2007	Insulin-dependent diabetes also was associated with higher late mortality (hazard ratio [HR], 1.5; 95% CI, 1.2-1.8; P = .001) and amputation rates (HR, 1.5; 95% CI, 1.0-2.1; P = .026), but other independent variables like age, elevated serum creatinine, critical preoperative ischemia, synthetic conduits, and previous ipsilateral bypass had at least as much influence as diabetes on survival, graft failure or limb loss.	Creatinine	242-252	insulin	Homo sapiens	0-7
17457621-5	2007	The median urine FN in VUR children was 224.1 (15.4-3537) ng/mg creatinine (Cr), compared with the control group: 137.9 (20.3-670.6) ng/mg Cr (p&lt;0.05), whereas median serum FN was 395.0 (13.0-779.9) ng/ml and 121.9 (25-345.1) ng/ml (p&lt;0.05), respectively.	Creatinine	64-74	fibronectin 1	Homo sapiens	17-19
17457621-5	2007	The median urine FN in VUR children was 224.1 (15.4-3537) ng/mg creatinine (Cr), compared with the control group: 137.9 (20.3-670.6) ng/mg Cr (p&lt;0.05), whereas median serum FN was 395.0 (13.0-779.9) ng/ml and 121.9 (25-345.1) ng/ml (p&lt;0.05), respectively.	Creatinine	76-78	fibronectin 1	Homo sapiens	17-19
17425653-4	2007	Plasma concentrations of TNF-alpha, IL-6, IL-10, IL-18, CCL2, CXCL8, CXCL9, CXCL10 and adiponectin exhibited significant positive correlation with urine albumin : creatinine ratio in DN patients.	Creatinine	163-173	tumor necrosis factor	Homo sapiens	25-34
17425653-4	2007	Plasma concentrations of TNF-alpha, IL-6, IL-10, IL-18, CCL2, CXCL8, CXCL9, CXCL10 and adiponectin exhibited significant positive correlation with urine albumin : creatinine ratio in DN patients.	Creatinine	163-173	adiponectin, C1Q and collagen domain containing	Homo sapiens	87-98
17697520-3	2007	In 67 patients with acute rejection, urinary VEGF was significantly higher (28.57 +/- 6.21 pg/micromol creatinine) than in the No-AR patients (3.05 +/- 0.45 pg/micromol creatinine) and healthy controls (2.87 +/- 0.35 pg/micromol creatinine).	Creatinine	103-113	vascular endothelial growth factor A	Homo sapiens	45-49
17697520-3	2007	In 67 patients with acute rejection, urinary VEGF was significantly higher (28.57 +/- 6.21 pg/micromol creatinine) than in the No-AR patients (3.05 +/- 0.45 pg/micromol creatinine) and healthy controls (2.87 +/- 0.35 pg/micromol creatinine).	Creatinine	169-179	vascular endothelial growth factor A	Homo sapiens	45-49
17697520-3	2007	In 67 patients with acute rejection, urinary VEGF was significantly higher (28.57 +/- 6.21 pg/micromol creatinine) than in the No-AR patients (3.05 +/- 0.45 pg/micromol creatinine) and healthy controls (2.87 +/- 0.35 pg/micromol creatinine).	Creatinine	169-179	vascular endothelial growth factor A	Homo sapiens	45-49
17697520-5	2007	The 13 patients with subclinical rejection excreted urinary VEGF (16.14 +/- 4.09 pg/micromol creatinine) at a significantly higher level than No-AR patients (3.05 +/- 0.45 pg/micromol creatinine).	Creatinine	93-103	vascular endothelial growth factor A	Homo sapiens	60-64
17697520-5	2007	The 13 patients with subclinical rejection excreted urinary VEGF (16.14 +/- 4.09 pg/micromol creatinine) at a significantly higher level than No-AR patients (3.05 +/- 0.45 pg/micromol creatinine).	Creatinine	184-194	vascular endothelial growth factor A	Homo sapiens	60-64
17430481-8	2007	The mean creatinine clearance at one year post-KT was 91.3 +/- 38.1 mls/min/1.73 m(2), with a projected graft life expectancy of 18.4 years.	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
17434879-10	2007	Moreover, reduced estimated creatinine clearance was an additional independent predictor of lower CD4 + T cell count slope (P = 0.02), but only after excluding nadir CD4 + T cell count.	Creatinine	28-38	CD4 molecule	Homo sapiens	98-101
17388597-7	2007	The isolable oxorhenium(V) hydride 4a reacts with PhCHO to afford the alkoxide Re(O)Cl2(OCH2Ph)(PPh3)2 (6a) with kinetic dependencies that are consistent with aldehyde coordination followed by aldehyde insertion into the Re-H bond.	Creatinine	27-34	caveolin 1	Homo sapiens	96-100
17243862-8	2007	We estimated baseline creatinine clearance (eGFR) using the Cockcroft Gault Formula.	Creatinine	22-32	epidermal growth factor receptor	Homo sapiens	44-48
17457470-7	2007	There was a strong correlation between serum transforming growth factor-beta 1 level and HbA1c, blood urea, serum creatinine and 24-hour urinary protein excretion (p&lt;0.01).	Creatinine	114-124	transforming growth factor beta 1	Homo sapiens	45-78
17329141-2	2007	We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.)	Creatinine	146-156	insulin like growth factor 1	Homo sapiens	79-84
17492567-12	2007	All creatinine-based formulae showed a high sensitivity and specifity for diagnosing a GFR below 60 ml/min/1,73m (2).	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
17425752-7	2007	Creatinine clearance after a mean follow-up of two yr was 100.7 mL/min/1.73 m(2) and 57.9 mL/min/1.73 m(2) in patients with systemic and localized TMA, respectively.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	67-72
17425752-7	2007	Creatinine clearance after a mean follow-up of two yr was 100.7 mL/min/1.73 m(2) and 57.9 mL/min/1.73 m(2) in patients with systemic and localized TMA, respectively.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
17242302-6	2007	Three (of 9) biomarkers were significantly related to incident hypertension on backward elimination (multivariable-adjusted odds ratios, per SD increment in biomarker): C-reactive protein (1.26; 95% CI: 1.05 to 1.51), plasminogen activator inhibitor-1 (1.28; 95% CI: 1.05 to 1.57), and urinary albumin/creatinine ratio (1.21; 95% CI: 1.02 to 1.43).	Creatinine	302-312	C-reactive protein	Homo sapiens	169-187
17067826-12	2007	Serum creatinine was significantly higher in patients with early re-stenosis, occlusion or stroke after CEA (P=0.043).	Creatinine	6-16	CEA cell adhesion molecule 3	Homo sapiens	104-107
17517342-6	2007	A multivariate Cox proportional hazards analysis showed that lower apoA-I levels (&lt; 103 mg/dL: determined by a receiver-operating characteristic analysis) were significantly associated with an adverse outcome that was independent of creatinine clearance, HDL cholesterol levels, and brain natriuretic peptide levels.	Creatinine	236-246	apolipoprotein A1	Homo sapiens	67-73
17142262-5	2007	The urinary albumin (U-Alb) level was measured as the albumin to creatinine excretion ratio in the urine.	Creatinine	65-75	albumin	Homo sapiens	23-26
17018847-9	2007	Impaired creatinine clearance and increased macrophage infiltration as well as glomerular and interstitial matrix deposition were prominent in TGR compared with SD, regardless of the presence or absence of diabetes.	Creatinine	9-19	thioredoxin reductase 3	Mus musculus	143-146
17364438-6	2007	These cases emphasize the need to consider SBMA and genetic testing for the androgen receptor trinucleotide CAG expansion in males otherwise healthy with "idiopathic" elevated creatinine kinase.	Creatinine	176-186	androgen receptor	Homo sapiens	76-93
16890218-4	2007	Among the women, the NAG and AMG were positively correlated with both the daily mercury intake and mercury levels in hair, toenail, and urine (P&lt;0.01); and, these relations were almost similar when using multiple regression analysis to adjust for possible confounders such as urinary cadmium (0.47+/-0.28 microg/g creatinine) and smoking status.	Creatinine	317-327	N-acetyl-alpha-glucosaminidase	Homo sapiens	21-24
17118352-10	2007	Changes in PON-1 activity display a good correlation (r=0.66, p&lt;0.001) with rates in which creatinine and urea are cleared.	Creatinine	94-104	paraoxonase 1	Homo sapiens	11-16
17059371-5	2007	MATERIALS AND METHODS: We studied the relationship between common polymorphisms of TGFB1 and several osteoporosis-related phenotypes including BMD at the lumbar spine and femoral neck, measured by DXA; bone loss over a 6-year period; biochemical markers of bone turnover (urinary free deoxypyridinoline and free pyridinoline/creatinine ratio and serum N-terminal propeptide of type 1 collagen), and fractures in a population-based study of 2975 women from the United Kingdom.	Creatinine	325-335	transforming growth factor beta 1	Homo sapiens	83-88
16759717-5	2007	RESULTS: In unadjusted analyses, CRP was positively correlated with age, male gender, body mass index, blood pressure, smoking habit, creatinine, uric acid, triglycerides, an index of insulin resistance, and 8-isoprostane, and inversely correlated with high-density lipoprotein-cholesterol.	Creatinine	134-144	C-reactive protein	Homo sapiens	33-36
17241054-3	2007	In contrast to alkyl monolayers, which desorb as alkene chains around 300 degrees C by the breaking of the Si-C bond through a beta-hydride elimination mechanism, the alkyl layers functionalized with a carboxylic acid terminal group undergo successive chemical transformations.	Creatinine	132-139	amyloid beta precursor protein	Homo sapiens	125-131
17230612-12	2007	In decompensated patients sFas, IL-6 and NOx levels correlated positively with creatinine levels, while IL-6 levels were dependent on Child class.	Creatinine	79-89	interleukin 6	Homo sapiens	32-36
17284895-8	2007	Intraperitoneal IL-6 was the significant and positive determinant of the time course of the D/P creatinine ratio (p &lt; 0.0001).	Creatinine	96-106	interleukin 6	Homo sapiens	16-20
16956351-7	2007	RESULTS: Erythropoietin significantly abrogated renal dysfunction after IRI compared with controls at 12 h after injury; the mean (sem) creatinine clearance (as a percentage of baseline) for IRI was 68.2 (6)% vs erythropoietin-IRI 94.9 (8.9)% (P = 0.027), although by 36 h this was no longer significant, with values of 73.8 (12.7)% vs 95.9 (12)%, respectively (P = 0.23).	Creatinine	136-146	erythropoietin	Sus scrofa	9-23
17910281-7	2007	NAG enzymuria (units/mmol creatinine) was increased in both diabetic groups compared to control values (group B: 122 +/- 7, group A: 70 +/- 5, controls 27 +/- 2, all P&lt;0.001).	Creatinine	26-36	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-3
17347908-8	2007	Furthermore, analysis of our results by non-parametric Kendall"s correlation at the start and one year later revealed negative correlation concerning dialysis duration, serum creatinine, and PTH.	Creatinine	175-185	parathyroid hormone	Homo sapiens	191-194
16849692-6	2007	These findings are consistent with the notion that urea and creatinine are continuously reabsorbed from the urine across the urothelium, urea in part via UT-B, and that urine is thus altered in its passage through the urinary tract.	Creatinine	60-70	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	154-158
17046733-5	2007	In the predialysis group, creatinine clearance correlated with Cu/Zn SOD and cytokine levels.	Creatinine	26-36	superoxide dismutase 1	Homo sapiens	63-72
17035377-5	2007	The patients with decreased creatinine clearance had higher parathyroid hormone (PTH) concentrations before and lower values after PTX compared with those who did not (594 +/- 392 vs 447 +/- 234 pg/ml before PTX, P = 0.03; 35 vs 123 pg/ml thereafter, P = 0.002).	Creatinine	28-38	parathyroid hormone	Homo sapiens	60-79
17035377-5	2007	The patients with decreased creatinine clearance had higher parathyroid hormone (PTH) concentrations before and lower values after PTX compared with those who did not (594 +/- 392 vs 447 +/- 234 pg/ml before PTX, P = 0.03; 35 vs 123 pg/ml thereafter, P = 0.002).	Creatinine	28-38	parathyroid hormone	Homo sapiens	81-84
17035377-8	2007	However, in multivariate analysis, only the delta PTH decline (%) after PTX was a significant predictor of deteriorating renal function (P = 0.005) and was correlated with the creatinine clearance decrease (R = 0.369, P = 0.001).	Creatinine	176-186	parathyroid hormone	Homo sapiens	50-53
17151331-8	2007	Greater rate of decline in creatinine clearance was associated with greater age, conventional insulin therapy during the DCCT, smoking, and greater glycosylated hemoglobin and AER at DCCT closeout but not with waist circumference.	Creatinine	27-37	insulin	Homo sapiens	94-101
17443034-5	2007	Since the serum adiponectin level is strongly affected by renal function, we classified the patients by creatinine clearance.	Creatinine	104-114	adiponectin, C1Q and collagen domain containing	Homo sapiens	16-27
17443034-6	2007	RESULTS: Multiple regression analysis showed the associations of adiponectin with creatinine clearance (p&lt;0.001), BMI (p&lt;0.001), serum triglyceride (p=0.001) and urinary protein excretion (p=0.001).	Creatinine	82-92	adiponectin, C1Q and collagen domain containing	Homo sapiens	65-76
17443034-7	2007	We observed a positive relation of adiponectin with urinary protein excretion and an inverse relation of adiponectin with creatinine clearance, serum triglyceride, and BMI.	Creatinine	122-132	adiponectin, C1Q and collagen domain containing	Homo sapiens	105-116
17402877-13	2007	Creatinine Clerance negatively correlated with the OGTT (r=-0.39, p=0.01) and plasma creatinine positively with fasting insulin (r=0.33, p=0.02) and C-peptide (r=0.42, p=0.006).	Creatinine	0-10	insulin	Homo sapiens	120-127
17596722-9	2007	There was a strong inverse correlation (r = -0.308; p &lt; 0.01) between changes in sNa and creatinine.	Creatinine	92-102	snail family transcriptional repressor 1	Homo sapiens	84-87
18074865-10	2007	Creatinine serum level was related to density of chymase-positive cells (R = 0.57), density of tryptase-positive cells (R = 0.59) and RIV (R = 0.77).	Creatinine	0-10	chymase 1	Homo sapiens	49-56
18074865-11	2007	On multiple regression analysis creatinine level was influenced by RIV but also by density of chymase-positive cells.	Creatinine	32-42	chymase 1	Homo sapiens	94-101
17497465-11	2007	CONCLUSION: Our study shows that the findings of normal serum levels of creatinine, lipids, and proteins increased the oxidizability of apolipoprotein B-containing lipoproteins, and any decrease in PON1 activity in patients diagnosed with GN should be considered important.	Creatinine	72-82	apolipoprotein B	Homo sapiens	136-152
17497465-11	2007	CONCLUSION: Our study shows that the findings of normal serum levels of creatinine, lipids, and proteins increased the oxidizability of apolipoprotein B-containing lipoproteins, and any decrease in PON1 activity in patients diagnosed with GN should be considered important.	Creatinine	72-82	paraoxonase 1	Homo sapiens	198-202
17994443-11	2007	We found only one important correlation, that between urinary VEGF levels and baseline serum creatinine levels in patients with different glomerulonephritis.	Creatinine	93-103	vascular endothelial growth factor A	Homo sapiens	62-66
17994443-15	2007	In addition to the important correlation between urinary VEGF and serum creatinine, we also found an important correlation between erythrocyte sedimentation rate and urinary VEGF.	Creatinine	72-82	vascular endothelial growth factor A	Homo sapiens	57-61
17181657-8	2007	In CRI group, TNFalpha correlated with serum creatinine, ICAM-1, and VCAM-1 (P = 0.01 for all).	Creatinine	45-55	tumor necrosis factor	Homo sapiens	14-22
16983178-9	2006	The urine calcium/creatinine (Ca/Cr) ratio that was high (&gt;0.4) before PTH injection decreased after PTH administration (0.4&gt;).	Creatinine	18-28	parathyroid hormone	Homo sapiens	104-107
17082756-2	2007	We examined the association that kidney function, based on glomerular filtration rate (eGFR) estimated from serum creatinine, has with serum levels of 25-hydroxyvitamin D and components of the metabolic syndrome among 14 679 participants in the Third National Health and Nutrition Examination Survey (NHANES III).	Creatinine	114-124	epidermal growth factor receptor	Homo sapiens	87-91
17725449-7	2007	Of the total patients with eGFR &lt; 60 ml/min 37.3% had normal serum creatinine levels.	Creatinine	70-80	epidermal growth factor receptor	Homo sapiens	27-31
16942925-3	2006	Urinary excretion of GGT, corrected for creatinine, was found to be increased in osteoprotegerin (OPG)-deficient osteoporotic mice as well as in patients with postmenopausal osteoporosis (67-83 years of age); in both cases the urinary level decreased after treatment of patients or mice with alendronate, a selective inhibitor of bone resorption, concomitantly with a reduction in DPD and NTX.	Creatinine	40-50	gamma-glutamyltransferase 1	Mus musculus	21-24
16966829-7	2006	Urinary adiponectin levels were also positively correlated with serum creatinine (r = 0.729, P&lt;0.0001), urinary albumin (r = 0.799, P&lt;0.0001), urinary NAG (r = 0.701, P&lt;0.0001), and urinary MCP-1 (r = 0.801, P&lt;0.0001) levels in all diabetic patients.	Creatinine	70-80	adiponectin, C1Q and collagen domain containing	Homo sapiens	8-19
16966829-8	2006	Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r(2) = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r(2) = 0.851).	Creatinine	54-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	137-148
16966829-8	2006	Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r(2) = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r(2) = 0.851).	Creatinine	54-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	137-148
16966829-8	2006	Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r(2) = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r(2) = 0.851).	Creatinine	54-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	137-148
17402877-13	2007	Creatinine Clerance negatively correlated with the OGTT (r=-0.39, p=0.01) and plasma creatinine positively with fasting insulin (r=0.33, p=0.02) and C-peptide (r=0.42, p=0.006).	Creatinine	85-95	insulin	Homo sapiens	120-127
17173245-10	2006	Furthermore, PON1 activity was significantly higher in nonprogressive patients compared with progressors (206 +/- 71 vs. 136 +/- 48; p&lt;0.001), and activity significantly correlated with 1/serum creatinine (SCr) (p&lt;0.001; r=0.38).	Creatinine	197-207	paraoxonase 1	Homo sapiens	13-17
17021608-9	2006	However, exosomal Fetuin-A increased 52.5-fold at day 2 (1 day before serum creatinine increase and tubule damage) and remained elevated 51.5-fold at day 5 (peak renal injury) after cisplatin injection.	Creatinine	76-86	alpha 2-HS glycoprotein	Homo sapiens	18-26
16728466-5	2006	A3AR KO mice also demonstrated significantly higher elevations in plasma creatinine, alanine aminotransferase, aspartate aminotransferase, keratinocyte-derived chemokine, and TNF-alpha 24 h after induction of sepsis compared with A3AR WT mice.	Creatinine	73-83	adenosine A3 receptor	Mus musculus	0-4
17003472-3	2006	IFN-gamma-deficient (IFN-gamma-/-) mice exhibited higher serum blood urea nitrogen and creatinine levels and exaggerated histopathological changes, compared with WT mice.	Creatinine	87-97	interferon gamma	Mus musculus	0-9
17003472-3	2006	IFN-gamma-deficient (IFN-gamma-/-) mice exhibited higher serum blood urea nitrogen and creatinine levels and exaggerated histopathological changes, compared with WT mice.	Creatinine	87-97	interferon gamma	Mus musculus	21-30
16984235-10	2006	Plasma creatinine levels were lower following IGF-I/IGFBP-3 complex (mean +/- SD, 56.2 +/- 16.8 micromol/l) vs placebo (61.5, 45.0, P &lt; 0.02).	Creatinine	7-17	insulin like growth factor 1	Homo sapiens	46-51
17031072-8	2006	AE1-329 suppressed the increase in creatinine and cholesterol compared to those in the control nephritic mice.	Creatinine	35-45	solute carrier family 4 (anion exchanger), member 1	Mus musculus	0-3
16900088-6	2006	The high NPHS2 promoter profile -116C/-51G haplotype was more frequent in patients with IgA nephropathy (P-value=0.005) and was associated with a better clinical outcome in terms of proteinuria and creatinine levels.	Creatinine	198-208	NPHS2 stomatin family member, podocin	Homo sapiens	9-14
17096695-4	2006	In the 17 patients with MPO-ANCA-associated glomerulonephritis, pretreatment creatinine was 3.2 +/- 1.6 mg/dL, and renal function recovered in 76.5%.	Creatinine	77-87	myeloperoxidase	Homo sapiens	24-27
17097961-11	2006	The need for EPO at 6 months postransplant was a good predictor of later renal allograft deterioration, more sensitive than serum creatinine or proteinuria.	Creatinine	130-140	erythropoietin	Homo sapiens	13-16
16914958-8	2006	The elimination of rigid limitations to increases in serum potassium and serum creatinine is suggested as a means to enhance prescription of renin-angiotensin system inhibitors.	Creatinine	79-89	renin	Homo sapiens	141-146
17091389-7	2006	Meanwhile, LK-4 (3 mg/kg) significantly inhibited the elevation of plasma tumor necrosis factor-alpha, as well as values of GOT and GPT, and BUN and creatinine caused by LPS.	Creatinine	149-159	toll-like receptor 4	Mus musculus	170-173
16936199-4	2006	Here, we show that inactivation of the RAGE gene in a mouse model of diabetic nephropathy results in significant suppression of kidney changes, including kidney enlargement, increased glomerular cell number, mesangial expansion, advanced glomerulosclerosis, increased albuminuria, and increased serum creatinine compared with wild-type diabetic mice.	Creatinine	301-311	advanced glycosylation end product-specific receptor	Mus musculus	39-43
16973514-8	2006	After adjusting for the effect of creatinine clearance, ferritin, and iPTH, there was still a significant correlation between EPO dose and FR(Na) (p &lt; 0.05).	Creatinine	34-44	erythropoietin	Homo sapiens	126-129
16788210-3	2006	Decreasing creatinine clearance showed a strong association with increasing apoA-IV levels.	Creatinine	11-21	apolipoprotein A4	Homo sapiens	76-83
16788210-4	2006	However, serum albumin levels significantly modulated apoA-IV levels in patients with low creatinine clearance, resulting in lower levels of apoA-IV in patients with low compared with high albumin levels (21.4 +/- 8.6 vs. 29.2 +/- 8.4 mg/dl; P = 0.0007).	Creatinine	90-100	albumin	Homo sapiens	15-22
16788210-4	2006	However, serum albumin levels significantly modulated apoA-IV levels in patients with low creatinine clearance, resulting in lower levels of apoA-IV in patients with low compared with high albumin levels (21.4 +/- 8.6 vs. 29.2 +/- 8.4 mg/dl; P = 0.0007).	Creatinine	90-100	apolipoprotein A4	Homo sapiens	54-61
16788210-6	2006	Especially patients with a tubular type of proteinuria had significantly higher amounts of apoA-IV in urine than those with a pure glomerular type of proteinuria and controls (median 45, 14, and 0.6 ng/mg creatinine, respectively).	Creatinine	205-215	apolipoprotein A4	Homo sapiens	91-98
17066218-5	2006	The usual laboratory tests must include calculation of the creatinine clearance, which is indispensable for dosage adjustment of certain drugs (ACE inhibitors, digoxin, spironolactone).	Creatinine	59-69	angiotensin I converting enzyme	Homo sapiens	144-147
16982454-7	2006	RESULTS: There was a positive correlation between long-term renal functions (loss of creatinine clearance rates) and in relative concentration of TGF-beta(1) urine 1 year after renal transplantation.	Creatinine	85-95	transforming growth factor beta 1	Homo sapiens	146-157
16880323-7	2006	In a Cox proportional-hazards model that adjusted for baseline variables, including demographics, clinical characteristics, creatinine clearance, ST deviation, index diagnosis, and troponin I, elevated H-FABP remained a significant predictor of the composite end point (HR, 1.9; 95% CI, 1.3 to 2.7), as well as the individual end points of death (HR, 2.7; 95% CI, 1.5 to 4.9) and CHF (HR, 2.4; 95% CI, 1.2 to 5.0).	Creatinine	124-134	fatty acid binding protein 3	Homo sapiens	202-208
16771812-4	2006	Mean residual creatinine clearance at transplantation of these patients was 8 mL/min/1.73 m(2).	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
17019548-7	2006	Compared to baseline, AVP increased systemic vascular resistance, decreased exposure to NE, decreased cardiac output by decreasing heart rate, increased creatinine clearance, and improved SOFA score.	Creatinine	153-163	arginine vasopressin	Homo sapiens	22-25
16906281-10	2006	Urinary NO3 excretion was significantly lower in IDV-treated patients (809 +/- 181 microM NO3-/mg creatinine) than in efavirenz-treated patients (2247 +/- 648 microM NO3-/mg creatinine, P &lt; 0.01).	Creatinine	98-108	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
16906281-10	2006	Urinary NO3 excretion was significantly lower in IDV-treated patients (809 +/- 181 microM NO3-/mg creatinine) than in efavirenz-treated patients (2247 +/- 648 microM NO3-/mg creatinine, P &lt; 0.01).	Creatinine	174-184	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
16911620-10	2006	Log EPO correlated significantly with urine microalbumin:creatinine ratio and logistic regression analysis showed that haemoglobin, age and urine microalbumin: creatinine ratio were the main determinants of EPO.	Creatinine	57-67	erythropoietin	Homo sapiens	4-7
16911620-10	2006	Log EPO correlated significantly with urine microalbumin:creatinine ratio and logistic regression analysis showed that haemoglobin, age and urine microalbumin: creatinine ratio were the main determinants of EPO.	Creatinine	160-170	erythropoietin	Homo sapiens	207-210
16804098-12	2006	CONCLUSIONS: In patients with a calculated creatinine clearance less than 51 mL/min/1.73 m(2), dosing according to their renal function can be improved.	Creatinine	43-53	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
16936905-6	2006	BTP values correlated with cystatin C (r = 0.75; p &lt; 0.01), creatinine (r = 0.73, p &lt; 0.01), GFR (r = -0.46; p = 0.02), urine alpha-1-microglobulin (r = 0.66; p &lt; 0.01).	Creatinine	63-73	prostaglandin D2 synthase	Homo sapiens	0-3
17699280-10	2006	The serum creatinine concentration increased from 3.02 +/- 0.27 to 3.38 +/- 0.49 mg/dl (candesartan plus ACE inhibitor group) versus 3.00 +/- 0.37 to 4.48 +/- 0.57 mg/dl (ACE inhibitor group; P &lt; 0.01) at year 3.	Creatinine	10-20	angiotensin I converting enzyme	Homo sapiens	171-174
16804063-5	2006	Like serum total adiponectin, HMW adiponectin correlated positively with HDL cholesterol and negatively with triglyceride, insulin sensitivity, creatinine clearance, and circulating inflammatory markers.	Creatinine	144-154	adiponectin, C1Q and collagen domain containing	Homo sapiens	34-45
16987073-4	2006	In our study, the highest creatinine levels were found in patients with the lowest ex vivo TNF-alpha production.	Creatinine	26-36	tumor necrosis factor	Homo sapiens	91-100
16987073-5	2006	Creatinine levels correlated inversely with TNF-alpha production (R = -0.35, p &lt; 0.05).	Creatinine	0-10	tumor necrosis factor	Homo sapiens	44-53
16709438-7	2006	Changes in ADPN correlated negatively with leptin, insulin resistance, albumin, C-reactive protein, and creatinine clearance.	Creatinine	104-114	adiponectin, C1Q and collagen domain containing	Homo sapiens	11-15
16834667-3	2006	The serum creatinine level was 1.6 mg/dL with a creatinine clearance of 27.3 mL/min/1.48 m(2) just prior to pregnancy.	Creatinine	10-20	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
16753018-11	2006	Urine level of deoxypyridinoline/creatinine and the mRNA levels of matrix metalloproteinase (MMP) -3, -9, and -13 in femurs were elevated in MIF Tg.	Creatinine	33-43	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	141-144
16708897-3	2006	creatinine and lipid peroxidation (LPO) content was found after administration of gentamicin (80 mg/kg/day, ip) for eight days along with significant decrease in the antioxidant enzymes, superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT) as well as brush border enzymes (Na+/K+ ATPase, Mg(+2)ATPase and Ca2+ ATPase).	Creatinine	0-10	catalase	Rattus norvegicus	242-250
16598197-7	2006	DPO or EPO at T0 significantly abrogated renal dysfunction in IRI animals (serum creatinine for IRI 0.17 +/- 0.05 mmol/l vs DPO-IRI 0.08 +/- 0.03 mmol/l vs EPO-IRI 0.04 +/- 0.01 mmol/l, P = 0.01).	Creatinine	81-91	erythropoietin	Homo sapiens	7-10
16598197-8	2006	Delayed administration of DPO or EPO (T6) also significantly abrogated subsequent renal dysfunction (serum creatinine for IRI 0.17 +/- 0.05 mmol/l vs DPO-IRI 0.06 +/- 0.01 mmol/l vs EPO-IRI 0.03 +/- 0.03 mmol/l, P = 0.01).	Creatinine	107-117	erythropoietin	Homo sapiens	33-36
16787522-10	2006	Indeed, the IL-8 levels were higher in diabetic subjects with ASB as compared with those without it (70.0 vs. &lt;3.1 pg/mg creatinine; p = 0.001), and there was a significant association between the urinary IL-8 concentration and the bacterial count (p = 0.001).	Creatinine	124-134	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
16787522-11	2006	Diabetic patients with leukocyturia had higher IL-8 concentration than those without it (20.9 vs. &lt;3.1 pg/mg creatinine; p = 0.003).	Creatinine	112-122	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
16708897-3	2006	creatinine and lipid peroxidation (LPO) content was found after administration of gentamicin (80 mg/kg/day, ip) for eight days along with significant decrease in the antioxidant enzymes, superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT) as well as brush border enzymes (Na+/K+ ATPase, Mg(+2)ATPase and Ca2+ ATPase).	Creatinine	0-10	catalase	Rattus norvegicus	252-255
16708897-3	2006	creatinine and lipid peroxidation (LPO) content was found after administration of gentamicin (80 mg/kg/day, ip) for eight days along with significant decrease in the antioxidant enzymes, superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT) as well as brush border enzymes (Na+/K+ ATPase, Mg(+2)ATPase and Ca2+ ATPase).	Creatinine	0-10	carbonic anhydrase 2	Rattus norvegicus	322-333
16585276-11	2006	To avoid dilution effects, urinary levels of IL-8 were expressed as the ratio of cytokine-to-urinary creatinine.	Creatinine	101-111	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
16516539-5	2006	RESULTS: A mean uDPD of 7.1+/-3.4nM/mM creatinine before IFN therapy decreased to 4.5+/-2.4 in the 4th week and 4.2+/-2.7 in the 24th week of IFN therapy, respectively (p&lt;0.0001).	Creatinine	39-49	interferon alpha 1	Homo sapiens	142-145
16524951-7	2006	Upregulation of HO-1 in HO-2 (-/-) mice by weekly administration of cobalt protoporphyrin prevented the increase in plasma creatinine levels and tubulointerstitial and microvascular pathology.	Creatinine	123-133	heme oxygenase 1	Mus musculus	16-20
16565250-4	2006	Of note, in an alternative model that included CRP (instead of endothelial function), the creatinine variance explained by this factor was two times higher (+10%) than that associated with endothelial function in the first model.	Creatinine	90-100	C-reactive protein	Homo sapiens	47-50
16552438-3	2006	Patients with creatinine clearance 30-50 ml min(-1) received a reduced dose of capecitabine (750 mg m(-2) twice daily).	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	44-50
16609690-0	2006	Elevated initial serum creatinine in Wegener"s granulomatosis with anti-myeloperoxidase autoantibodies.	Creatinine	23-33	myeloperoxidase	Homo sapiens	72-87
16520949-9	2006	Positive correlations were found between cytokine concentrations, CRP and urea/creatinine levels.	Creatinine	79-89	C-reactive protein	Homo sapiens	66-69
16699299-8	2006	Subsequently, GF significantly increased with time from transplant (p=0.01), while fasting C-peptide and the area under the curve of insulin correlated with creatinine clearance.	Creatinine	157-167	insulin	Homo sapiens	91-100
16699299-8	2006	Subsequently, GF significantly increased with time from transplant (p=0.01), while fasting C-peptide and the area under the curve of insulin correlated with creatinine clearance.	Creatinine	157-167	insulin	Homo sapiens	133-140
16490622-9	2006	The next day and 2 days after angiography, urinary L-FABP levels increased significantly to 46.8 +/- 30.5 microg/g Cr (range, 12.0 to 84.5 microg/g Cr; P &lt; 0.01) and 38.5 +/- 28.5 microg/g Cr (range, 9.5 to 70.5 microg/g Cr; P &lt; 0.01) in the contrast medium-induced nephropathy group, respectively.	Creatinine	115-117	fatty acid binding protein 1	Homo sapiens	51-57
17699215-8	2006	Baseline urine TGF-beta1 was 4.14 +/- 1.16 pg/mg creatinine.	Creatinine	49-59	transforming growth factor beta 1	Homo sapiens	15-24
16690460-6	2006	Increasing PTH was also significantly correlated with increasing body mass index, age, and serum creatinine and with decreasing dietary calcium intake and serum 25-OHD levels.	Creatinine	97-107	parathyroid hormone	Homo sapiens	11-14
16690460-10	2006	Factors to be considered in analysis of serum PTH values in the upper reference range in patients with normocalcemia include obesity, race, 25-OHD levels, advanced age, serum creatinine, and dietary calcium intake.	Creatinine	175-185	parathyroid hormone	Homo sapiens	46-49
16532260-9	2006	The decrease in creatinine clearance was accompanied by an increase in urinary L-FABP, but not in urinary protein.	Creatinine	16-26	fatty acid binding protein 1	Homo sapiens	79-85
16544182-5	2006	After the induction of ACE-I in this patient, the rate of regression of renal function was significantly reduced and his serum creatinine was maintained at almost the same level for 18 months.	Creatinine	127-137	angiotensin I converting enzyme	Homo sapiens	23-26
16736416-13	2006	Urinary excretion of IL-6 was significantly related with urinary IL-1 beta, both expressed as pg/ml/mg of urinary creatinine (r=0.85, p&lt;0.0001).	Creatinine	114-124	interleukin 6	Homo sapiens	21-25
16736416-13	2006	Urinary excretion of IL-6 was significantly related with urinary IL-1 beta, both expressed as pg/ml/mg of urinary creatinine (r=0.85, p&lt;0.0001).	Creatinine	114-124	interleukin 1 beta	Homo sapiens	65-74
16677358-9	2006	The mean creatinine clearance was 96+/-24 mL/min/1.73 m2 at steroid withdrawal and 93+/-20 mL/min/1.73 m2 at the latest follow-up.	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	45-50
16534238-8	2006	Creatinine clearance increased from 20 +/- 15 ml/min/1.73 m2 at the start of tacrolimus therapy to 37 +/- 29 ml/min/1.73 m2 and to 32 +/- 26 ml/min/1.73 m2 after 5 and 7 years.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
16330466-8	2006	Urinary TGF-beta1 level was reduced in all three therapies compared with that of the control (28.4 +/- 16.1 pg/mg cr) (P &lt; 0.05).	Creatinine	114-116	transforming growth factor beta 1	Homo sapiens	8-17
16448897-0	2006	Albumin-to-creatinine ratio predicts change in ambulatory blood pressure in normotensive persons: a 7.5-year prospective study.	Creatinine	11-21	albumin	Homo sapiens	0-7
16448897-7	2006	RESULTS: Baseline albumin-to-creatinine ratio was not associated with baseline ambulatory BP, but was positively associated with change in ambulatory BP.	Creatinine	29-39	albumin	Homo sapiens	18-25
16448897-8	2006	Before and after controlling for sex, race/ethnicity, age, body mass index at baseline, and change in body mass index, urinary albumin-to-creatinine ratio was found to be a significant independent predictor of change in awake and sleep systolic and diastolic BPs (all P &lt; .05).	Creatinine	138-148	albumin	Homo sapiens	127-134
16448897-10	2006	CONCLUSIONS: In healthy normotensive individuals, the urinary albumin-to-creatinine ratio predicts change in ambulatory BPs 7.5 years later.	Creatinine	73-83	albumin	Homo sapiens	62-69
16430721-13	2006	Furthermore, changes in total IGF-I and IGFBP-3 correlated to changes in serum creatinine levels in the metabolically stable patients (r=0.58, P=0.02 and r=0.6, P=0.01, respectively).	Creatinine	79-89	insulin like growth factor 1	Homo sapiens	30-35
16395263-5	2006	Compared to controls, the urinary PlGF and PlGF/creatinine levels were significantly reduced in women with pre-eclampsia.	Creatinine	48-58	placental growth factor	Homo sapiens	43-47
16534182-7	2006	RESULTS: Before treatment, the urinary L-FABP levels in 30 CKD patients (84.0 +/- 68.5 microg/g creatinine) were significantly higher than those of healthy subjects (6.4 +/- 4.2 mug/g creatinine; p &lt; 0.001).	Creatinine	96-106	fatty acid binding protein 1	Homo sapiens	39-45
16534182-7	2006	RESULTS: Before treatment, the urinary L-FABP levels in 30 CKD patients (84.0 +/- 68.5 microg/g creatinine) were significantly higher than those of healthy subjects (6.4 +/- 4.2 mug/g creatinine; p &lt; 0.001).	Creatinine	184-194	fatty acid binding protein 1	Homo sapiens	39-45
16374436-7	2006	Baseline levels of NT-CNP (212, 150-303 pmol/l, median and 25th and 75th percentiles) were much higher than recorded previously in healthy volunteers or in heart failure, and correlated with plasma creatinine (rs=0.53, P&lt;0.05).	Creatinine	198-208	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	22-25
16879063-3	2006	We researched the relationship between serum uric acid, creatinine and albumin levels in pregnant women with normal glucose tolerance and gestational diabetes mellitus.	Creatinine	56-66	albumin	Homo sapiens	71-78
16534238-8	2006	Creatinine clearance increased from 20 +/- 15 ml/min/1.73 m2 at the start of tacrolimus therapy to 37 +/- 29 ml/min/1.73 m2 and to 32 +/- 26 ml/min/1.73 m2 after 5 and 7 years.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	112-117
16534238-8	2006	Creatinine clearance increased from 20 +/- 15 ml/min/1.73 m2 at the start of tacrolimus therapy to 37 +/- 29 ml/min/1.73 m2 and to 32 +/- 26 ml/min/1.73 m2 after 5 and 7 years.	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	112-117
16685140-5	2006	Serum creatinine level increased from 1.34 +/- 0.20 to 1.53 +/- 0.27 mg/dl in the ACE inhibitor group and from 1.33 +/- 0.18 to 1.45 +/- 0.19 mg/dl in the control group (p &lt; 0.001).	Creatinine	6-16	angiotensin I converting enzyme	Homo sapiens	82-85
16898499-7	2006	FN was measured in 24-h urine collections (ng/mg of creatinine), using specific antibody (DAKO) and proteinuria (mg/24h).	Creatinine	52-62	fibronectin 1	Homo sapiens	0-2
16374436-9	2006	We conclude that plasma levels of NT-CNP are grossly elevated in chronic renal failure and correlated with plasma creatinine, but are not altered by peritoneal dialysis.	Creatinine	114-124	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	37-40
16268803-13	2005	A moderate correlation was found between PRL and creatinine levels (r = 0.609, P &lt; 0.001).	Creatinine	49-59	prolactin	Homo sapiens	41-44
17441364-8	2006	Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18.	Creatinine	6-16	interleukin 6	Homo sapiens	33-37
17441364-8	2006	Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18.	Creatinine	6-16	tumor necrosis factor	Homo sapiens	46-54
16538969-9	2006	The assay defined as fragmentation of 3-cresolsulfonphthaleinyl-N-acetyl-beta-D-glucosaminide molecule by NAG to 3-cresolsulphonphthalein and N-acetylglucosamine molecules and serum creatinine were measured in all groups.	Creatinine	182-192	N-acetyl-alpha-glucosaminidase	Homo sapiens	106-109
16338452-7	2005	FINDINGS: Comparisons of ACE inhibitors or ARBs with other antihypertensive drugs yielded a relative risk of 0.71 (95% CI 0.49-1.04) for doubling of creatinine and a small benefit on end-stage renal disease (relative risk 0.87, 0.75-0.99).	Creatinine	149-159	angiotensin I converting enzyme	Homo sapiens	25-28
16378798-3	2005	METHODS: This study is a cross-sectional analysis to evaluate cystatin-C, creatinine, and eGFR as predictors of the inflammatory markers C-reactive protein and fibrinogen.	Creatinine	74-84	C-reactive protein	Homo sapiens	137-155
16378798-9	2005	In contrast, both C-reactive protein and fibrinogen had U-shaped associations with quintiles of creatinine and eGFR, because the inflammatory markers were equivalently elevated in quintiles 1 and 5.	Creatinine	96-106	C-reactive protein	Homo sapiens	18-36
16378798-9	2005	In contrast, both C-reactive protein and fibrinogen had U-shaped associations with quintiles of creatinine and eGFR, because the inflammatory markers were equivalently elevated in quintiles 1 and 5.	Creatinine	96-106	fibrinogen beta chain	Homo sapiens	41-51
16281961-6	2005	When serum creatinine is still normal, the erythropoietin concentration is predictive of more rapid loss of glomerular function.	Creatinine	11-21	erythropoietin	Homo sapiens	43-57
16281964-4	2005	A positive correlation between haemoglobin concentration and creatinine clearance has been reported, which is a function of endogenous erythropoietin production by the functioning graft.	Creatinine	61-71	erythropoietin	Homo sapiens	135-149
16471322-7	2005	WT1 transcripts increased when clinical factors worsen, including the stage, amount of M protein, Hb, platelet count, blood urea nitrogen (BUN), creatinine, serum alkaline phosphatase (ALP), calcium, beta2-microglobulin, thymidine kinase activity (TK), and C-reactive protein (CRP).	Creatinine	145-155	WT1 transcription factor	Homo sapiens	0-3
16192425-9	2005	IL-6 that was produced in response to renal ischemia was maladaptive because transgenic knockout of IL-6 ameliorated renal injury as measured by serum creatinine and histology.	Creatinine	151-161	interleukin 6	Mus musculus	0-4
16249547-9	2005	RESULTS: Urinary l-FABP levels in groups A-D were 6.2 +/- 4.6 microg/g creatinine, 19.6 +/- 13.5 microg/g creatinine, 26.8 +/- 20.4 microg/g creatinine, and 52.4 +/- 46.8 microg/g creatinine, respectively.	Creatinine	71-81	fatty acid binding protein 1	Homo sapiens	17-23
16192425-9	2005	IL-6 that was produced in response to renal ischemia was maladaptive because transgenic knockout of IL-6 ameliorated renal injury as measured by serum creatinine and histology.	Creatinine	151-161	interleukin 6	Mus musculus	100-104
16249547-9	2005	RESULTS: Urinary l-FABP levels in groups A-D were 6.2 +/- 4.6 microg/g creatinine, 19.6 +/- 13.5 microg/g creatinine, 26.8 +/- 20.4 microg/g creatinine, and 52.4 +/- 46.8 microg/g creatinine, respectively.	Creatinine	106-116	fatty acid binding protein 1	Homo sapiens	17-23
16249547-9	2005	RESULTS: Urinary l-FABP levels in groups A-D were 6.2 +/- 4.6 microg/g creatinine, 19.6 +/- 13.5 microg/g creatinine, 26.8 +/- 20.4 microg/g creatinine, and 52.4 +/- 46.8 microg/g creatinine, respectively.	Creatinine	106-116	fatty acid binding protein 1	Homo sapiens	17-23
16198934-15	2005	A Pearson correlation analysis showed that there was a positive correlation between D/P creatinine levels and 36-month mean CRP levels (r = 0.608, P &lt; .0001), and a negative correlation between D/P creatinine levels and 36-month mean albumin levels (r = -0.299, P &lt; .005).	Creatinine	88-98	C-reactive protein	Homo sapiens	124-127
16249547-9	2005	RESULTS: Urinary l-FABP levels in groups A-D were 6.2 +/- 4.6 microg/g creatinine, 19.6 +/- 13.5 microg/g creatinine, 26.8 +/- 20.4 microg/g creatinine, and 52.4 +/- 46.8 microg/g creatinine, respectively.	Creatinine	106-116	fatty acid binding protein 1	Homo sapiens	17-23
16221222-10	2005	The prevalence of elevated initial serum creatinine was significantly higher in patients with MPO-ANCA than that in patients with PR3-ANCA (81.5% vs. 61.8%, chi(2) = 4.20, P &lt; 0.05).	Creatinine	41-51	myeloperoxidase	Homo sapiens	94-97
15961410-5	2005	Ucn-I enhanced urinary sodium excretion (5.3-fold, P=0.0001) and creatinine clearance (1.3-fold, P=0.0055) long-term, and tended to increase urine output (P=0.0748).	Creatinine	65-75	urocortin	Ovis aries	0-3
16275827-8	2005	tHcy levels positively correlated with plasma Abeta levels even after adjustments for age and creatinine (p < 0.0001).	Creatinine	94-104	amyloid beta precursor protein	Homo sapiens	46-51
16115856-11	2005	In multiple regression analysis, waist circumference, log sICAM-1 concentration, gender, creatinine clearance and current smoking were independently associated with CRP.	Creatinine	89-99	C-reactive protein	Homo sapiens	165-168
16101728-4	2005	Our results show that high levels of IFN-gamma in pretransplant mixed lymphocyte culture are a highly significant predictor of poorer creatinine levels at 18, 24 and 36 months post-transplant.	Creatinine	134-144	interferon gamma	Homo sapiens	37-46
16386505-6	2005	PARP-1 showed a statistically significant relationship with the time required to achieve effective diuresis (Rho:0.779), with serum creatinine, and with duration of cold ischemia (Rho:0.803).	Creatinine	132-142	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
16386505-8	2005	In conclusion, multivariate analysis demonstrated that PARP-1 expression and cold ischemia duration in kidney biopsies with ATN predicted the short-term delay in total recovery of renal function and serum creatinine in the first month.	Creatinine	205-215	poly(ADP-ribose) polymerase 1	Homo sapiens	55-61
16245436-9	2005	This should probably be undertaken in RAS patients with rapidly deteriorating renal function, refractory hypertension and in whom plasma creatinine concentration has increased by &gt;20% during one month long administration of angiotensin-converting enzyme inhibitor.	Creatinine	137-147	angiotensin I converting enzyme	Homo sapiens	227-256
16191261-7	2005	(2) A significantly positive correlation was found between the level of urinary S100B protein within three days and the urinary lactate/creatinine ratio within the first day and between the level of urinary S100B protein within three days and clinical degree (P &lt; 0.05).	Creatinine	136-146	S100 calcium binding protein B	Homo sapiens	80-85
16191261-8	2005	(3) When S100B concentration was 0.47 microg/L and urinary lactate/creatinine ratio was 0.55, the sensitivity and specificity of detecting the third day urinary S100B alone, were respectively 90.4%, 91.9%.	Creatinine	67-77	S100 calcium binding protein B	Homo sapiens	161-166
16191261-10	2005	CONCLUSION: On the basis of clinical manifestations of asphyxic neonatals, detecting the level of urinary S100B within three days and the first day urinary lactate/creatinine ratio may be of important value in early diagnosis and grading of HIE.	Creatinine	164-174	S100 calcium binding protein B	Homo sapiens	106-111
16194413-0	2005	[Can angiotensin-converting enzyme inhibitor be used in chronic kidney disease patients with serum creatinine level greater than 266 micromol/L?].	Creatinine	99-109	angiotensin I converting enzyme	Homo sapiens	5-34
15943636-6	2005	After transplantation, CT correlated with serum creatinine.	Creatinine	48-58	calcitonin related polypeptide alpha	Homo sapiens	23-25
15849223-6	2005	During IL-2 therapy a statistical significant increase in white blood cells (WBC), creatinine, gamma-glutamyltransferase, C-reactive protein, glucose and body weight was observed.	Creatinine	83-93	interleukin 2	Homo sapiens	7-11
15970406-2	2005	Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults.	Creatinine	49-59	fatty acid binding protein 1	Homo sapiens	8-14
15956057-5	2005	RESULTS: Cross-sectional analysis showed nPCR being significantly less at lower creatinine clearance.	Creatinine	80-90	nasopharyngeal carcinoma-related protein	Homo sapiens	41-45
16299682-11	2005	There was a significant positive correlation between serum Cys C, urinary NAG, LDH, ALP activities and serum Cr levels.	Creatinine	109-111	N-acetyl-alpha-glucosaminidase	Homo sapiens	74-77
16299682-11	2005	There was a significant positive correlation between serum Cys C, urinary NAG, LDH, ALP activities and serum Cr levels.	Creatinine	109-111	alkaline phosphatase, placental	Homo sapiens	84-87
15963971-5	2005	RESULTS: Cu/Zn SOD levels were significantly higher in chronic renal failure (CRF) patients (P &lt; 0.05), and in both dialyzed groups (both P &lt; 0.001) than in controls, and were positively correlated with MDA, creatinine (both P &lt; 0.001) and OxLDL-Ab (P &lt; 0.01) in the whole uremic group.	Creatinine	214-224	superoxide dismutase 1	Homo sapiens	9-18
16450015-5	2005	The reference interval for serum creatinine concentration includes up to 25% of people (particularly thin, elderly women) who have an estimated glomerular filtration rate (eGFR) that is significantly reduced (&lt; 60 mL/min/1.73 m).	Creatinine	33-43	CD59 molecule (CD59 blood group)	Homo sapiens	220-225
16014048-5	2005	RESULTS: Ang II infusion affected on neither the deposition of Ig nor mesangiolysis in the initial phase, and resulted in the aggravation of creatinine clearance at day 14 and 35 after initiating anti-Thy-1.1 nephritis.	Creatinine	141-151	angiotensinogen	Rattus norvegicus	9-15
16012455-11	2005	In logistic regression adjusted for age, sex, lipid-lowering therapy, active treatment, gangrene, leukocyte count, creatinine, and serum HDL cholesterol, the inflammatory mediators tumor necrosis factor-alpha (P = .0084), neopterin (P = .0035), but not interleukin-6 (P = .585) or high-sensitivity C-reactive protein (P = .314) were independent risk variables of death within 1 year.	Creatinine	115-125	tumor necrosis factor	Homo sapiens	181-208
16053416-5	2005	The reference interval for serum creatinine concentration includes up to 25% of people (particularly thin, elderly women) who have an estimated glomerular filtration rate (eGFR) that is significantly reduced (&lt; 60 mL/min/1.73 m2).	Creatinine	33-43	CD59 molecule (CD59 blood group)	Homo sapiens	220-225
16022092-11	2005	Interestingly, we found a negative correlation between log ADPN and creatinine levels among the CPD patients (r = -0.54, p &lt; 0.05).	Creatinine	68-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	59-63
16022092-13	2005	Creatinine and low-density lipoprotein levels could account for 54% of the total variation in ADPN levels.	Creatinine	0-10	adiponectin, C1Q and collagen domain containing	Homo sapiens	94-98
16022092-14	2005	CONCLUSION: Among pediatric CPD patients, serum levels of the anti-atherogenic protein, ADPN, were inversely associated with creatinine.	Creatinine	125-135	adiponectin, C1Q and collagen domain containing	Homo sapiens	88-92
15957132-6	2005	Gremlin messenger RNA levels correlated directly with renal dysfunction, determined by means of serum creatinine level, but not with proteinuria level.	Creatinine	102-112	gremlin 1, DAN family BMP antagonist	Homo sapiens	0-7
16037290-7	2005	The relationship with serum creatinine decreased but remained significant after adjusting for age, sex, diabetes duration, hemoglobin A1c (HbA1c), AER, systolic and diastolic blood pressure (BP), and CRP in multiple linear-regression analysis.	Creatinine	28-38	C-reactive protein	Homo sapiens	200-203
15931621-2	2005	We examined the role of creatinine clearance (CrCl) and body composition in the development of insulin resistance in patients with primary renal disease and a variable degree of renal failure.	Creatinine	24-34	insulin	Homo sapiens	95-102
15897361-6	2005	A significant association between smoking and low adiponectin level was also confirmed in multiple regression analysis including age, body mass index, hypertension, diabetes, hyperlipidemia, and creatinine clearance (never-smokers 6.5+/-0.4 microg/mL; past smokers 5.6+/-0.3 microg/mL; current smokers 5.2+/-0.4 microg/mL; F=4.52; P=0.01).	Creatinine	195-205	adiponectin, C1Q and collagen domain containing	Homo sapiens	50-61
15909599-13	2005	After cessation of COX-2 inhibitor treatment, patients recovered completely with a normalized serum creatinine level after one to two months.	Creatinine	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15897668-9	2005	Adiponectin correlated significantly, in univariate analysis, with CD146 (r = 0.29, p = 0.009), thrombomodulin (r = 0.37, p = 0.001), protein Z (r = -0.25, p = 0.03), BMI (r = -0.26, p = 0.047), serum creatinine (r = 0.26, p = 0.02) and urea (r = 0.38, p = 0.001).	Creatinine	201-211	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
15840028-9	2005	In experiment 3, anti-TNF-alpha treatment significantly reduced urine protein to creatinine ratio and urinary MCP-1 levels.	Creatinine	81-91	tumor necrosis factor	Rattus norvegicus	22-31
15952076-4	2005	Proper evaluation of the first parameter requires correction for the active metabolic mass, which is best performed by expressing CPR per gram of urinary creatinine.	Creatinine	154-164	cytochrome p450 oxidoreductase	Homo sapiens	130-133
15322741-9	2005	The Bio-PTH/I-PTH ratio correlated significantly in a negative manner with serum calcium (Ca) (r=-0.251, P&lt;0.001) and nutritional marker serum urea nitrogen, protein catabolic rate and serum creatinine.	Creatinine	194-204	parathyroid hormone	Homo sapiens	8-11
15322741-9	2005	The Bio-PTH/I-PTH ratio correlated significantly in a negative manner with serum calcium (Ca) (r=-0.251, P&lt;0.001) and nutritional marker serum urea nitrogen, protein catabolic rate and serum creatinine.	Creatinine	194-204	parathyroid hormone	Homo sapiens	14-17
15921030-1	2005	BACKGROUND: We have previously shown that apolipoprotein E (apo E-) polymorphism may affect serum creatinine concentration and predicted glomerular filtration rate in healthy individuals.	Creatinine	98-108	apolipoprotein E	Homo sapiens	42-58
15921030-1	2005	BACKGROUND: We have previously shown that apolipoprotein E (apo E-) polymorphism may affect serum creatinine concentration and predicted glomerular filtration rate in healthy individuals.	Creatinine	98-108	apolipoprotein E	Homo sapiens	60-65
15921030-5	2005	RESULTS: The apo E-2 allele was associated with lower serum levels of total cholesterol, higher levels of triglycerides and apo E-, and increased serum creatinine concentration compared with the apo E-3 and apo E-4 alleles in our population.	Creatinine	152-162	apolipoprotein E	Homo sapiens	13-20
15921030-5	2005	RESULTS: The apo E-2 allele was associated with lower serum levels of total cholesterol, higher levels of triglycerides and apo E-, and increased serum creatinine concentration compared with the apo E-3 and apo E-4 alleles in our population.	Creatinine	152-162	apolipoprotein E	Homo sapiens	13-18
15921030-7	2005	These observations remained statistically significant when the effect of apo E- polymorphism on SUA levels was adjusted for gender, age, systolic and diastolic blood pressure, body mass index, serum creatinine, and triglyceride and apo E- levels, as well as for HOMA index and FEUA.	Creatinine	199-209	apolipoprotein E	Homo sapiens	73-78
15705187-4	2005	METHODS AND RESULTS: In patients with plasma creatinine values &lt; or =1.5 (n = 53) or &gt;1.5 mg/dL (n = 19), the mean serum EPO was 5.6 +/- 4.4 and 10.2 +/- 7.0 mU/mL (P = 0.02), respectively.	Creatinine	45-55	erythropoietin	Homo sapiens	127-130
15866623-5	2005	The increase in the immunohistochemical expression of PARP-1 showed a statistically significant relationship with the duration of cold ischemia, with serum creatinine levels, and with the time required to achieve effective diuresis (P &lt; .0001, Spearman test).	Creatinine	156-166	poly(ADP-ribose) polymerase 1	Homo sapiens	54-60
15866623-6	2005	Cold ischemia of &gt;24 hours and serum creatinine levels &gt;1.7 mg/dL showed a statistically significant relationship with the highest PARP-1 expression levels (2.83 +/- 0.4 vs 1.36 +/- 0.8, P &lt; .0001, Mann-Whitney U test).	Creatinine	40-50	poly(ADP-ribose) polymerase 1	Homo sapiens	137-143
15743788-7	2005	However, treatment with Smad7 substantially inhibited Smad2/3 activation and prevented progressive renal injury by inhibiting the rise of 24-hour proteinuria (P &lt; 0.001) and serum creatinine (P &lt; 0.001), preserving creatinine clearance (P &lt; 0.05), and attenuating renal fibrosis and vascular sclerosis such as collagen I and III expression (P &lt; 0.01) and myofibroblast accumulation (P &lt; 0.001).	Creatinine	183-193	SMAD family member 7	Rattus norvegicus	24-29
15743788-7	2005	However, treatment with Smad7 substantially inhibited Smad2/3 activation and prevented progressive renal injury by inhibiting the rise of 24-hour proteinuria (P &lt; 0.001) and serum creatinine (P &lt; 0.001), preserving creatinine clearance (P &lt; 0.05), and attenuating renal fibrosis and vascular sclerosis such as collagen I and III expression (P &lt; 0.01) and myofibroblast accumulation (P &lt; 0.001).	Creatinine	221-231	SMAD family member 7	Rattus norvegicus	24-29
15830271-5	2005	RESULTS: In 150 healthy subjects, urinary L-FABP averaged 3.6 +/- 0.2 microg/g creatinine, whereas the values were significantly increased in patients with hypertension (5.2 +/- 0.4, P = 0.010), diabetes mellitus (5.5 +/- 0.5, P &lt; 0.001), and chronic hepatitis (5.8 +/- 1.0, P = 0.022).	Creatinine	79-89	fatty acid binding protein 1	Homo sapiens	42-48
15830271-6	2005	Urinary L-FABP excretion was significantly greater in women than in men when the value was related to creatinine.	Creatinine	102-112	fatty acid binding protein 1	Homo sapiens	8-14
15871303-4	2005	Initially creatinine clearance (Ccr) was similar in the 2 groups; however, the urinary L-FABP level was significantly higher in the former group than in the latter (111.5 vs 53 microg/g creatinine, P &lt; .001).	Creatinine	186-196	fatty acid binding protein 1	Homo sapiens	87-93
15871303-5	2005	For the monitoring CKD, we set the cutoff values for urinary L-FABP and urinary protein at 17.4 microg/g creatinine and 1.0 g/g creatinine, respectively.	Creatinine	105-115	fatty acid binding protein 1	Homo sapiens	61-67
15871303-5	2005	For the monitoring CKD, we set the cutoff values for urinary L-FABP and urinary protein at 17.4 microg/g creatinine and 1.0 g/g creatinine, respectively.	Creatinine	128-138	fatty acid binding protein 1	Homo sapiens	61-67
15906952-6	2005	Intraglomerular TGF-beta1 mRNA expression was significantly correlated with creatinine clearance (r = -0.764, p = 0.027), daily proteinuria (r = 0.781, p = 0.022), serum creatinine (r = 0.884, p = 0.004), and tubulointerstitial changes (r = 0.809, p = 0.015).	Creatinine	76-86	transforming growth factor beta 1	Homo sapiens	16-25
15906952-6	2005	Intraglomerular TGF-beta1 mRNA expression was significantly correlated with creatinine clearance (r = -0.764, p = 0.027), daily proteinuria (r = 0.781, p = 0.022), serum creatinine (r = 0.884, p = 0.004), and tubulointerstitial changes (r = 0.809, p = 0.015).	Creatinine	170-180	transforming growth factor beta 1	Homo sapiens	16-25
15848522-10	2005	Significantly higher creatinine concentrations were found among recipients with II genotype compared to the combined group of ID and DD among patients not treated with ACE inhibitors, but not among those receiving ACE I after kidney transplantation.	Creatinine	21-31	angiotensin I converting enzyme	Homo sapiens	168-171
15599770-6	2005	NAG/Cr levels correlated with erythrocyte sedimentation rate (r=0.66, P&lt;0.001) and platelet count (r=0.61, P&lt;0.001) and showed a slight correlation with the number of joints with active arthritis in children with polyarticular JIA (r=0.45, P=0.055).	Creatinine	4-6	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-3
15947836-7	2005	RESULTS: Patients presenting creatinine clearance &lt; 30 ml/min/1.73 m(2) had higher iPTH values, but normal serum levels for calcium, phosphorus, alkaline phosphatase and tCO2.	Creatinine	29-39	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
16091636-4	2005	At baseline these patients had significantly lower catalase activity which was associated with elevated blood glucose, circulating immune complexes, creatinine, and proteinuria.	Creatinine	149-159	catalase	Homo sapiens	51-59
15339849-3	2005	p53 deletions were associated with higher serum calcium (P = .0062) and creatinine (P = .013) levels, but there were no association with patient age, gender, beta2-microglobulin, C-reactive protein, hemoglobin, albumin or bone lytic lesions, or immunoglobulin isotype.	Creatinine	72-82	tumor protein p53	Homo sapiens	0-3
16239187-9	2005	With respect to the serum cTnT level at 12 hours, creatinine clearance (Ccr) had a slight effect on the serum cTnT values.	Creatinine	50-60	troponin T2, cardiac type	Homo sapiens	110-114
15589469-7	2005	RESULTS: While renal function (glomerular filtration rate [GFR]) deteriorated progressively under cyclosporine, it stabilised and even improved under tacrolimus (creatinine: Delta(Cyc)=+1.4 mg/d; Delta(Tac=)-0.7 mg/dl; GFR: Delta(Cyc)=-35 ml/min; Delta(Tac)=14 ml/min).	Creatinine	162-172	cytochrome c, somatic	Homo sapiens	180-183
16362602-11	2005	In 10 patients with a rise in serum creatinine on recent introduction of ACE inhibition, 2 had evidence of RAS on renal arteriography.	Creatinine	36-46	angiotensin I converting enzyme	Homo sapiens	73-76
16120550-6	2005	Six covariates (height-weight-hemoglobin-AST-ALT-creatinine) were found to influence MTX volume of distribution (V) and elimination rate constant (K(el)).	Creatinine	49-59	solute carrier family 17 member 5	Homo sapiens	41-44
16296406-3	2005	2) A urinary albumin-to-creatinine ratio ranging from 30 to 299 mg/ gCr in 2 or more of 3 specimens may be diagnosed as microalbuminuria.	Creatinine	24-34	nuclear receptor subfamily 3 group C member 1	Homo sapiens	68-71
15610240-7	2005	The urinary VEGF levels were positively correlated with the urinary albumin to creatinine ratio (ACR), urinary sFLT-1 levels, and negatively correlated with creatinine clearance.	Creatinine	79-89	vascular endothelial growth factor A	Homo sapiens	12-16
15610240-7	2005	The urinary VEGF levels were positively correlated with the urinary albumin to creatinine ratio (ACR), urinary sFLT-1 levels, and negatively correlated with creatinine clearance.	Creatinine	157-167	vascular endothelial growth factor A	Homo sapiens	12-16
15585515-11	2005	A positive relationship was also found between plasma adiponectin and the urinary albumin/creatinine ratio (P = 0.007).	Creatinine	90-100	adiponectin, C1Q and collagen domain containing	Homo sapiens	54-65
15818056-3	2005	RESULTS: Urinary excretion of OM with more anioic charge and smaller MR than albumin, and Tf with more cationic charge and slightly larger molecular weight than albumin, significantly increased in parallel with increased creatinine clearances after acute protein loading.	Creatinine	221-231	transferrin	Homo sapiens	90-92
15957550-7	2005	Moreover, positive correlations between urinary adiponectin levels and albumin-to-creatinine ratios were observed in IgA-nephropathy (R2=0.53, P&lt;0.01) and diabetic nephropathy patients (R2=0.61, P&lt;0.01), but not in control subjects.	Creatinine	82-92	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
16334978-10	2005	Moreover, the tubulointerstitial immunoexpression of TGF-beta-1 was significantly positively correlated with renal interstitial cortical volume and serum creatinine in patients with lupus nephritis.	Creatinine	154-164	transforming growth factor beta 1	Homo sapiens	53-63
16078597-5	2005	After administration of ACE inhibitors in doses lowering arterial pressure not higher than 130/80 mm Hg and statins reducing serum cholesterol nitric residues stopped accumulating while serum creatinine went down after 5 months of the combined treatment.	Creatinine	192-202	angiotensin I converting enzyme	Homo sapiens	24-27
15573169-3	2004	In contrast, protonation of the analogous hydride compounds with Mes or Cy substituents on phosphorus give the corresponding unsaturated tetracarbonyls [Mo2Cp2(mu-PHR)(CO)4]+, which are unstable at room temperature and display a cis geometry.	Creatinine	42-49	MYC binding protein 2	Homo sapiens	163-166
16060094-1	2005	Authors present an 11-year old girl with non-specific clinical symptoms with increase of inflammatory indices and acute non-oliguric renal failure: creatinine clearance - 55 ml/min/1.73 m2.	Creatinine	148-158	CD59 molecule (CD59 blood group)	Homo sapiens	177-182
15369420-12	2004	However, a combination of the ARB plus the ACE inhibitor produced both a significant reduction in urinary protein excretion beyond that seen with either agent alone and a significantly greater protection against progression to doubling of serum creatinine or ESRD.	Creatinine	245-255	angiotensin I converting enzyme	Homo sapiens	43-46
15589812-4	2004	RESULTS: Circulating ET-1 levels were found to be positively correlated with creatinine (r = 0.25, p &lt; 0.01) and systolic blood pressure (r = 0.20, p &lt; 0.05) and inversely correlated with high-density lipoprotein cholesterol (HDL-C) levels (r = -0.27, p &lt; 0.01).	Creatinine	77-87	endothelin 1	Homo sapiens	21-25
15589812-6	2004	Only creatinine, HDL-C, and age &gt;40 years were shown to be independent correlates for ET-1 levels according to multivariate analyses.	Creatinine	5-15	endothelin 1	Homo sapiens	89-93
15490252-8	2004	Prior to CyA treatment, the urinary TGF-beta1 level was the highest (135.61+/-38.31 pg/mg creatinine).	Creatinine	90-100	transforming growth factor beta 1	Homo sapiens	36-45
15490252-9	2004	During CyA treatment, TGF-beta1 was reduced to 117.96+/-81.57 after 3 months, to 80.26+/-49.52 after 6 months, and to 44.00+/-31.83 pg/mg creatinine after 12 months, but it was still higher than in the control group.	Creatinine	138-148	transforming growth factor beta 1	Homo sapiens	22-31
15631649-5	2004	(3) The abnormal increase of coagulation factor VII was positively correlated with levels of blood uria nitrogen and serum creatinine before hemodialysis but not after hemodialysis.	Creatinine	123-133	coagulation factor VII	Homo sapiens	29-51
15531669-9	2004	Moreover, negative correlations were observed between IL-6 and serum creatinine (rho = -0.19, P &lt; 0.01), handgrip strength (rho = -0.24, P &lt; 0.001), and serum albumin (rho = -0.34, P &lt; 0.001).	Creatinine	69-79	interleukin 6	Homo sapiens	54-58
15504980-4	2004	Compared with noncarriers of the aldose reductase z-2 allele (n = 92) and z-2 heterozygotes (n = 77), z-2 homozygotes (n = 17) had elevated plasma creatinine (164.1 +/- 73.7 vs. 190.6 +/- 60.9 vs. 241.1 +/- 86.2 micromol/l; P &lt; 0.001) and an increased risk of classic diabetic glomerulopathy (OR 1 vs. 0.9 vs. 3.3; P = 0.026).	Creatinine	147-157	aldo-keto reductase family 1 member B	Homo sapiens	33-49
15482412-8	2004	Patients with creatinine &gt; or = 1.6 mg dL(-1) were likely to discontinue ACE inhibitors because of renal dysfunction (HR: 4.7; 95% CI: 1.5-12.7) and hyperkalaemia (HR: 10.9; 95% CI: 3.1-39.0).	Creatinine	14-24	angiotensin I converting enzyme	Homo sapiens	76-79
15451906-8	2004	Serum adiponectin concentration correlated negatively with the 24-h LF-to-HF ratio (r = -0.343, P = 0.0009) and creatinine clearance (r = -0.411, P &lt; 0.0001).	Creatinine	112-122	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
15648545-11	2004	No correlation was observed between CgA and the variables measured, except between CgA and plasma creatinine (r=0.472, p&lt;0.05).	Creatinine	98-108	chromogranin A	Homo sapiens	83-86
15363445-6	2004	The selective iNOS inhibitor, S-methylisothiourea (MTU), suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products, suppressed the increases of serum creatinine and UN, and improved renal histological aggravations induced by hemorrhaging.	Creatinine	170-180	nitric oxide synthase 2	Rattus norvegicus	14-18
15280527-3	2004	METHODS: We compared the rate of deterioration in renal function, expressed as the regression coefficient of the monthly serum creatinine (SeCr) reciprocal (beta-1/Cr) in 55 Chinese type 2 diabetic patients before and after entry into the RENAAL Study.	Creatinine	127-137	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	157-166
15500378-4	2004	Based on the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) study, losartan is also indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria, in patients with Type 2 diabetes.	Creatinine	197-207	angiotensinogen	Homo sapiens	54-68
15507849-5	2004	RESULTS: Urinary IL-6 and IL-8 levels [IL-6, IL-8/creatinine (pg/mg)] were significantly higher in group I than in group II (Il-6 level: 39.4+/-41.1 vs. 6.3+/-13.7, p&lt;0.01; IL-8 level: 791.1+/-1143.6 vs. 36+/-87.9, p&lt;0.001).	Creatinine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
15536593-2	2004	OLETF rats showed glomerular hyperfiltration (an increase in creatinine clearance and a decrease in fractional excretion of Na) and microalbuminuria at the insulin-resistant prediabetic stage, and both were related to expression of transforming growth factor (TGF)-beta(1) and extracellular matrix protein such as fibronectin and collagen (a(1)) IV.	Creatinine	61-71	transforming growth factor, beta 1	Rattus norvegicus	232-272
15559485-16	2004	When analyzed as continuous variables, MTAC creatinine was related to VEGF (r= 0.33, p &lt; 0.05) and CA125 (r= 0.41, p = 0.03).	Creatinine	44-54	vascular endothelial growth factor A	Homo sapiens	70-74
15559485-17	2004	In linear regression analysis, VEGF influenced the association between CA125 and MTAC creatinine; IL-6 weakened this association only marginally.	Creatinine	86-96	vascular endothelial growth factor A	Homo sapiens	31-35
15559485-19	2004	The relationships found between VEGF, CA125, and MTAC creatinine may suggest a role of VEGF in the regulation of the vascular peritoneal surface area, possibly already before structural abnormalities have developed.	Creatinine	54-64	vascular endothelial growth factor A	Homo sapiens	32-36
15559485-19	2004	The relationships found between VEGF, CA125, and MTAC creatinine may suggest a role of VEGF in the regulation of the vascular peritoneal surface area, possibly already before structural abnormalities have developed.	Creatinine	54-64	vascular endothelial growth factor A	Homo sapiens	87-91
15489090-8	2004	Although ACE inhibitor users with creatinine clearances &gt; or =60 ml/min had lower 12-month mortality (OR 0.72, 95% CI 0.48 to 0.99), ACE inhibitor users with clearances &lt;60 ml/min did not (OR 1.21, 95% CI 0.97 to 1.51).	Creatinine	34-44	angiotensin I converting enzyme	Homo sapiens	9-12
15539791-9	2004	When combined with diabetes, Ang II increased albumin excretion rate (14-fold, p &lt; 0.05), plasma creatinine (1.5-fold, p &lt; 0.005) worsened creatinine clearance (37%, p &lt; 0.002) and increased glomerular basement membrane width (1.2-fold, p &lt; 0.0001).	Creatinine	145-155	angiotensinogen	Rattus norvegicus	29-35
15327419-9	2004	Above a creatinine clearance of 40 mL/min a significant inverse correlation between erythropoietin and hemoglobin levels was observed and described with the formula erythropoietin [U/L]= 2.5 x (140 - hemoglobin [g/L]) or alternatively Deltaerythropoietin (U/L) =-2.5 xDeltahemoglobin (g/L).	Creatinine	8-18	erythropoietin	Homo sapiens	84-98
15327419-9	2004	Above a creatinine clearance of 40 mL/min a significant inverse correlation between erythropoietin and hemoglobin levels was observed and described with the formula erythropoietin [U/L]= 2.5 x (140 - hemoglobin [g/L]) or alternatively Deltaerythropoietin (U/L) =-2.5 xDeltahemoglobin (g/L).	Creatinine	8-18	erythropoietin	Homo sapiens	165-179
15327419-11	2004	CONCLUSION: A cut-off level for an altered set point of erythropoietin regulation was determined at 40 mL/min creatinine clearance.	Creatinine	110-120	erythropoietin	Homo sapiens	56-70
15289383-9	2004	ACE inhibitor prescription was associated with lower crude 1-year mortality (33.0% versus 42.1%, P&lt;0.001), lower risk of death after adjustment (RR 0.86, 95% CI 0.82 to 0.90), and lower mortality regardless of patient gender, age, race, or serum creatinine level.	Creatinine	249-259	angiotensin I converting enzyme	Homo sapiens	0-3
15289371-6	2004	C-reactive protein was related directly to serum creatinine and inversely to GFR and vasodilatory response to ACh, which suggests that endothelial dysfunction is a possible mechanism linking inflammation and impaired renal function in essential hypertension.	Creatinine	49-59	C-reactive protein	Homo sapiens	0-18
15276511-5	2004	Multivariable analyses were performed for aortic regions to assess the relationship of atheroma burden and APOE epsilon4 status with peak in-hospital postoperative serum creatinine.	Creatinine	170-180	apolipoprotein E	Homo sapiens	107-111
15187200-8	2004	Although, ApoE4 carriers tended to exhibit lower levels of serum creatinine and higher values of predicted GFR compared with the E3 carries, these differences did not reach statistical significance.	Creatinine	65-75	apolipoprotein E	Homo sapiens	10-15
15039142-3	2004	When provided free access to water, PKC-alpha -/- mice showed approximately 50% greater urine flow rate and lower urinary osmolality in 24-h metabolic cage experiments despite a greater urinary vasopressin-to-creatinine ratio vs. PKC-alpha +/+ mice.	Creatinine	209-219	protein kinase C, alpha	Mus musculus	36-45
15270783-6	2004	RESULTS: Plasma and urinary TGF-beta1 levels were significantly lower in controls (4.7 (1.6-6.8) ng/ml P &lt; 0.001; 5.7 (1.5-8.5) ng/mg urinary creatinine, P &lt; 0.01) than in patients with Type 1 diabetes mellitus [10.5 (1.8-24.9) ng/ml; 10.1 (4.2-29.8) ng/mg urinary creatinine].	Creatinine	145-155	transforming growth factor beta 1	Homo sapiens	28-37
15270783-6	2004	RESULTS: Plasma and urinary TGF-beta1 levels were significantly lower in controls (4.7 (1.6-6.8) ng/ml P &lt; 0.001; 5.7 (1.5-8.5) ng/mg urinary creatinine, P &lt; 0.01) than in patients with Type 1 diabetes mellitus [10.5 (1.8-24.9) ng/ml; 10.1 (4.2-29.8) ng/mg urinary creatinine].	Creatinine	271-281	transforming growth factor beta 1	Homo sapiens	28-37
15292342-5	2004	Both urinary albumin to creatinine ratio (ACR) and serum creatinine were positively correlated with adiponectin (Spearman"s r = 0.43; P &lt; 0.0001, and r = 0.37; P &lt; 0.0001, respectively) in diabetic subjects.	Creatinine	24-34	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
15292342-5	2004	Both urinary albumin to creatinine ratio (ACR) and serum creatinine were positively correlated with adiponectin (Spearman"s r = 0.43; P &lt; 0.0001, and r = 0.37; P &lt; 0.0001, respectively) in diabetic subjects.	Creatinine	57-67	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
15187200-0	2004	Influence of apolipoprotein E polymorphisms on serum creatinine levels and predicted glomerular filtration rate in healthy subjects.	Creatinine	53-63	apolipoprotein E	Homo sapiens	13-29
15187200-7	2004	These observations remained significant statistically even if the effect of ApoE polymorphisms on age- and body-mass index-adjusted serum creatinine and MDRD-predicted GFR was separately analysed in both men and women.	Creatinine	138-148	apolipoprotein E	Homo sapiens	76-80
15239024-10	2004	3) Adiponectin levels are dependent on renal function at a creatinine clearance &lt; 45 ml/min.	Creatinine	59-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	3-14
15257469-4	2004	A significant change in urinary EPX excretion was only observed in the high dose group [200 micro g: - 10.3 micro g/mmol creatinine (- 116.2 to 50.5), p = 0.9; 800 micro g: - 49.2 micro g/mmol creatinine (- 231.0 to 48.7), p = 0.02].	Creatinine	121-131	eosinophil peroxidase	Homo sapiens	32-35
15257469-4	2004	A significant change in urinary EPX excretion was only observed in the high dose group [200 micro g: - 10.3 micro g/mmol creatinine (- 116.2 to 50.5), p = 0.9; 800 micro g: - 49.2 micro g/mmol creatinine (- 231.0 to 48.7), p = 0.02].	Creatinine	193-203	eosinophil peroxidase	Homo sapiens	32-35
15168387-7	2004	Conversely, serum creatinine levels decreased significantly faster in patients administered an ACE inhibitor/ATII blocker than in those without therapy (P &lt; 0.01).	Creatinine	18-28	angiotensin I converting enzyme	Homo sapiens	95-98
15149328-10	2004	AGT excretion in final urine corrected for creatinine and kidney weight was also elevated by UNX at seven weeks (UNX = 209 +/- 42 pmol/mg/g, sham = 147 +/- 29 pmol/mg/g, P &lt;.05), with no difference in plasma AGT between UNX and control animals.	Creatinine	43-53	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-3
15212162-3	2004	METHODS: Transport of [14C]creatinine by human organic ion transporters (SLC22A) was assessed by HEK293 cells expressing hOCT1, hOCT2, hOCT2-A, hOAT1, and hOAT3.	Creatinine	27-37	solute carrier family 22 member 1	Homo sapiens	121-126
15147359-8	2004	In type I diabetics, anti-GAD65 antibody levels were associated (multiple R 0.6, P = 0.01) positively with sIL-6R, negatively with duration of diabetes and CD23(+)CD25(+) counts; plasma creatinine correlated positively (multiple R 0.6, P &lt; 0.001) with both sIL-2R and tumour necrosis factor (TNF)-alpha concentration.	Creatinine	186-196	glutamate decarboxylase 2	Homo sapiens	26-31
15187200-9	2004	CONCLUSIONS: ApoE2 allele seems to be associated with increased serum creatinine levels and decreased MDRD-predicted GFR in healthy subjects.	Creatinine	70-80	apolipoprotein E	Homo sapiens	13-18
15198481-10	2004	In patients with severe ARAS, ACE inhibitor use, calcium channel blocker use and diuretic use were shown to correlate significantly with serum creatinine levels after controlling for potential confounding factors.	Creatinine	143-153	angiotensin I converting enzyme	Homo sapiens	30-33
15142195-9	2004	However, production of interferon-gamma by concanavalin A-stimulated peripheral blood mononuclear cells was lower in active Crohn"s disease (P = 0.02) and correlated negatively with the deoxypyridinoline/creatinine:osteocalcin ratio (r = -0.40, P = 0.004).	Creatinine	204-214	interferon gamma	Homo sapiens	23-39
15135199-9	2004	Nitrate/nitrite level, glutamic oxalacetic transaminase (GOT) level and creatinine level were also significantly improved in AG+ANGII-treated rats compared to the other groups.	Creatinine	72-82	angiotensinogen	Rattus norvegicus	128-133
15110646-6	2004	RESULTS: Immunohistochemical expression of PARP-1 showed a statistically significant relationship with donor age (r =.408, P =.006, Spearman test), with time required to achieve effective diuresis (r =.386, P =.01, Spearman test) and with creatinine levels in the first 3 months.	Creatinine	239-249	poly(ADP-ribose) polymerase 1	Homo sapiens	43-49
15050501-1	2004	This study shows that elevated high-sensitivity C-reactive protein and plasma total homocysteine contribute independently to the likelihood of an increased urinary albumin:creatinine ratio.	Creatinine	172-182	C-reactive protein	Homo sapiens	48-66
15036704-3	2004	RESULTS: In women with subsequent preeclampsia, both VEGF (213.19+/-78.42 pg/ml) and NO concentrations (4.31+/-1.02 micromol/mg creatinine) were significantly lower than healthy controls (VEGF 255.05+/-88.66 pg/ml; NO 5.02+/-1.57 microg/mg creatinine; P&lt;0.05).	Creatinine	240-250	vascular endothelial growth factor A	Homo sapiens	53-57
15103543-3	2004	This anaemia results from erythropoietin deficiency, which seems to develop in patients with type 1 diabetes even at relatively "normal" levels of serum creatinine.	Creatinine	153-163	erythropoietin	Homo sapiens	26-40
15012614-12	2004	CgA levels were significantly related to age (P&lt;0.001), creatinine levels (P=0.03) and the severity of hypertension (P=0.002).	Creatinine	59-69	chromogranin A	Homo sapiens	0-3
15528877-10	2004	The urine albumin/creatinine ratio was highly correlated with the plasma ET-1 level (r = 0.62; p &lt; 0.01) and plasma TNF-a level (r = 0.66, p &lt; 0.01).	Creatinine	18-28	endothelin 1	Homo sapiens	73-77
14976397-9	2004	Patients with increased serum creatinine since the initial phase after transplantation (groups 2a and 3a) revealed a higher percentage of CD4+CD40L+ cells than patients showing a gradual increase over time (groups 2b and 3b).	Creatinine	30-40	CD4 molecule	Homo sapiens	138-141
14976397-9	2004	Patients with increased serum creatinine since the initial phase after transplantation (groups 2a and 3a) revealed a higher percentage of CD4+CD40L+ cells than patients showing a gradual increase over time (groups 2b and 3b).	Creatinine	30-40	CD40 ligand	Homo sapiens	142-147
15017529-6	2004	A strong association exists between acute increases in serum creatinine of up to 30% to 35% after initiating ACE inhibitor therapy and long-term preservation of renal function.	Creatinine	61-71	angiotensin I converting enzyme	Homo sapiens	109-112
15017529-9	2004	Thus, withdrawal of an ACE inhibitor in such patients should occur only when the rise in creatinine exceeds this threshold over a shorter period of time or hyperkalemia develops, ie, serum potassium level of 5.6 mmol/L or greater.	Creatinine	89-99	angiotensin I converting enzyme	Homo sapiens	23-26
14673630-5	2004	In children with chronic allograft dysfunction ( n=8), treatment with ACE-I stabilized graft function, with improvement in creatinine clearance in 50% ( p&lt;0.01).	Creatinine	123-133	angiotensin I converting enzyme	Homo sapiens	70-73
15384786-8	2004	In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6.	Creatinine	27-37	vascular endothelial growth factor A	Homo sapiens	137-141
15759544-7	2004	In addition in Tx patients both PTH-1-84 and PTH-7-84 showed a significant positive correlation with plasma creatinine, OC, AP and Ctx and a negative one with BMD T score, while in HS PTH-1-84 and PTH-7-84 were positively correlated with OC and AP and negatively with Ca and BMD (borderline significance).	Creatinine	108-118	parathyroid hormone	Homo sapiens	32-35
15759544-7	2004	In addition in Tx patients both PTH-1-84 and PTH-7-84 showed a significant positive correlation with plasma creatinine, OC, AP and Ctx and a negative one with BMD T score, while in HS PTH-1-84 and PTH-7-84 were positively correlated with OC and AP and negatively with Ca and BMD (borderline significance).	Creatinine	108-118	parathyroid hormone	Homo sapiens	45-48
15759544-7	2004	In addition in Tx patients both PTH-1-84 and PTH-7-84 showed a significant positive correlation with plasma creatinine, OC, AP and Ctx and a negative one with BMD T score, while in HS PTH-1-84 and PTH-7-84 were positively correlated with OC and AP and negatively with Ca and BMD (borderline significance).	Creatinine	108-118	parathyroid hormone	Homo sapiens	45-48
15759544-7	2004	In addition in Tx patients both PTH-1-84 and PTH-7-84 showed a significant positive correlation with plasma creatinine, OC, AP and Ctx and a negative one with BMD T score, while in HS PTH-1-84 and PTH-7-84 were positively correlated with OC and AP and negatively with Ca and BMD (borderline significance).	Creatinine	108-118	parathyroid hormone	Homo sapiens	45-48
14709365-6	2004	A stepwise multiple regression model found CRP directly correlated with BMI (P&lt;0.01) and serum creatinine (P&lt;0.01), and inversely correlated with PLP (P&lt;0.01).	Creatinine	98-108	C-reactive protein	Homo sapiens	43-46
15528877-10	2004	The urine albumin/creatinine ratio was highly correlated with the plasma ET-1 level (r = 0.62; p &lt; 0.01) and plasma TNF-a level (r = 0.66, p &lt; 0.01).	Creatinine	18-28	tumor necrosis factor	Homo sapiens	119-124
14693711-7	2004	In RAGE antibody-treated db/db mice, the increase in kidney weight, glomerular volume, mesangial volume, and UAE was reduced, whereas the increase in creatinine clearance and BMT was fully normalized.	Creatinine	150-160	advanced glycosylation end product-specific receptor	Mus musculus	3-7
15077930-3	2004	In women with severe preeclampsia VEGF levels were 54.0 (19.9-192.4) ng/mmol creatinine, significantly (p&lt;0.0001) higher than levels in pregnant controls (28.2 (6.7-63.0) ng/mmol creatinine) and non-pregnant controls (29.5 (10.1-59.1) ng/mmol creatinine).	Creatinine	77-87	vascular endothelial growth factor A	Homo sapiens	34-38
15077930-3	2004	In women with severe preeclampsia VEGF levels were 54.0 (19.9-192.4) ng/mmol creatinine, significantly (p&lt;0.0001) higher than levels in pregnant controls (28.2 (6.7-63.0) ng/mmol creatinine) and non-pregnant controls (29.5 (10.1-59.1) ng/mmol creatinine).	Creatinine	182-192	vascular endothelial growth factor A	Homo sapiens	34-38
15077930-3	2004	In women with severe preeclampsia VEGF levels were 54.0 (19.9-192.4) ng/mmol creatinine, significantly (p&lt;0.0001) higher than levels in pregnant controls (28.2 (6.7-63.0) ng/mmol creatinine) and non-pregnant controls (29.5 (10.1-59.1) ng/mmol creatinine).	Creatinine	182-192	vascular endothelial growth factor A	Homo sapiens	34-38
14579936-7	2003	CONCLUSION: Withdrawal of ACE inhibitor causes the deterioration of renal function in patients with the II or DI genotypes, high proteinuria after the withdrawal, and high serum creatinine level at the withdrawal, which probably causes the rebound increase in serum ACE activity.	Creatinine	178-188	angiotensin I converting enzyme	Homo sapiens	26-29
14749682-7	2004	Urinary L-FABP was correlated with urinary protein, urinary alpha(1)-microglobulin, and serum creatinine concentrations.	Creatinine	94-104	fatty acid binding protein 1	Homo sapiens	8-14
14749682-8	2004	Urinary L-FABP at the start of follow-up (F = 17.1, r =.36, P &lt;.0001) was selected as a significant clinical factor correlated with the progression rate, defined as a slope of a reciprocal of serum creatinine over time.	Creatinine	201-211	fatty acid binding protein 1	Homo sapiens	8-14
14675041-11	2004	However, only low dose TGF-beta antibody improved renal function and sclerosis measured by serum creatinine and creatinine clearance (serum creatinine, control 2.3 +/- 0.5 mg/dL; high 2.5 +/- 0.5 mg/dL; low 0.8 +/- 0.1 mg/dL; P &lt; 0.05 low vs. control and high; creatinine clearance, control 0.44 +/- 0.11 mL/min; high 0.70 +/- 0.26 mL/min; low 1.34 +/- 0.30 mL/min; P &lt; 0.05 low vs. control, P= NS vs. high).	Creatinine	97-107	transforming growth factor, beta 1	Rattus norvegicus	23-31
14675041-11	2004	However, only low dose TGF-beta antibody improved renal function and sclerosis measured by serum creatinine and creatinine clearance (serum creatinine, control 2.3 +/- 0.5 mg/dL; high 2.5 +/- 0.5 mg/dL; low 0.8 +/- 0.1 mg/dL; P &lt; 0.05 low vs. control and high; creatinine clearance, control 0.44 +/- 0.11 mL/min; high 0.70 +/- 0.26 mL/min; low 1.34 +/- 0.30 mL/min; P &lt; 0.05 low vs. control, P= NS vs. high).	Creatinine	112-122	transforming growth factor, beta 1	Rattus norvegicus	23-31
14675041-11	2004	However, only low dose TGF-beta antibody improved renal function and sclerosis measured by serum creatinine and creatinine clearance (serum creatinine, control 2.3 +/- 0.5 mg/dL; high 2.5 +/- 0.5 mg/dL; low 0.8 +/- 0.1 mg/dL; P &lt; 0.05 low vs. control and high; creatinine clearance, control 0.44 +/- 0.11 mL/min; high 0.70 +/- 0.26 mL/min; low 1.34 +/- 0.30 mL/min; P &lt; 0.05 low vs. control, P= NS vs. high).	Creatinine	112-122	transforming growth factor, beta 1	Rattus norvegicus	23-31
14675041-11	2004	However, only low dose TGF-beta antibody improved renal function and sclerosis measured by serum creatinine and creatinine clearance (serum creatinine, control 2.3 +/- 0.5 mg/dL; high 2.5 +/- 0.5 mg/dL; low 0.8 +/- 0.1 mg/dL; P &lt; 0.05 low vs. control and high; creatinine clearance, control 0.44 +/- 0.11 mL/min; high 0.70 +/- 0.26 mL/min; low 1.34 +/- 0.30 mL/min; P &lt; 0.05 low vs. control, P= NS vs. high).	Creatinine	112-122	transforming growth factor, beta 1	Rattus norvegicus	23-31
15022606-7	2004	Usual values were determined for healthy subjects: the mean concentration of NO2/NO3 (Unox) was 51.1 +/- 5.3 micromole/mmol creatinine (mean +/- SEM) (n = 15).	Creatinine	124-134	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
15051932-8	2004	RESULTS: The slope of the reciprocal serum creatinine concentration over time became significantly less steep in the AST-120 group than in the non-AST-120 group (p &lt; 0.001).	Creatinine	43-53	solute carrier family 17 member 5	Homo sapiens	117-120
15218325-1	2004	BACKGROUND: We recently reported that haptoglobin (Hp) phenotype 1-1 is protective against the development of nephropathy in normal creatinine diabetics.	Creatinine	132-142	haptoglobin	Homo sapiens	38-49
15116821-5	2004	RESULTS: N-acetyl-beta-D-glucosaminidase indexed to urinary creatinine (U-NAG/crea), a sensitive marker of renal proximal tubular damage, increased similarly in both groups at the end of surgery (two-way ANOVA, p &lt; 0.05).	Creatinine	60-70	N-acetyl-alpha-glucosaminidase	Homo sapiens	74-77
14672353-11	2003	Urine DPD/creatinine, a marker of bone resorption, was significantly reduced by 25% from baseline in the 800-microg GLP-2 group (p &lt; 0.01).	Creatinine	10-20	glucagon	Homo sapiens	116-121
14633154-6	2003	Plasma CF6 level was positively correlated with serum creatinine level (r=0.36, P &lt; 0.01) and was reduced after dialysis (P &lt; 0.05).	Creatinine	54-64	ATP synthase peripheral stalk subunit F6	Homo sapiens	7-10
14566107-10	2003	Serum creatinine and urea levels were associated with the RIV of the kidney and to a smaller degree with the number of myofibroblasts and CD34+ cells.	Creatinine	6-16	CD34 molecule	Homo sapiens	138-142
14569094-4	2003	In a Cox proportional hazards model corrected for other risk factors, the D allele (ACE/ID) was associated with time to doubling of s-creatinine/ESRD (rate ratio, 1.81 per allele; 95% confidence interval, 1.09 to 3.03; P = 0.02).	Creatinine	134-144	angiotensin I converting enzyme	Homo sapiens	84-87
15384786-8	2004	In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6.	Creatinine	27-37	vascular endothelial growth factor A	Homo sapiens	188-192
15384786-8	2004	In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6.	Creatinine	27-37	interleukin 6	Homo sapiens	196-200
18202474-4	2004	All the patients had irreversible levels for creatinine corresponding approximately to a glomerular filtration rate less than 50 ml/min/1.73 m 2 .	Creatinine	45-55	CD59 molecule (CD59 blood group)	Homo sapiens	132-137
14702530-10	2003	Daily serum creatinine (PODs 1-4) was higher in the SRL-treated group compared with the control group (P&lt;0.05 at all time points).	Creatinine	12-22	transcription factor 21	Rattus norvegicus	24-32
14740347-10	2003	The indices of renal functions, i.e. albuminuria (r = 0.37; p &lt; 0.0001) and serum creatinine (r = 0.22; p = 0.015), significantly correlated with fibrinogen levels.	Creatinine	85-95	fibrinogen beta chain	Homo sapiens	149-159
14655192-8	2003	Similarly, creatinine level correlated with both enPCR and CRP level.	Creatinine	11-21	C-reactive protein	Homo sapiens	59-62
14655192-12	2003	CONCLUSION: Albumin and creatinine levels are independently associated with nutrition (enPCR) and inflammation (CRP level).	Creatinine	24-34	C-reactive protein	Homo sapiens	112-115
14655192-14	2003	CRP level is associated with reduced albumin and creatinine values when increased to values greater than 5.6 mg/dL.	Creatinine	49-59	C-reactive protein	Homo sapiens	0-3
14638927-9	2003	Renal function at the first week posttransplantation (analyzed by serum creatinine levels) showed a significant correlation with both HO-1 and VEGF mRNA expression, reinforcing the protective role of both genes in the early events of transplantation.	Creatinine	72-82	vascular endothelial growth factor A	Homo sapiens	143-147
14671148-6	2003	Pegvisomant-induced serum IGF-I normalization (699 +/- 76 to 242 +/- 28 micro g/liter, P &lt; 0.001) was associated with a significant decrease in PIIINP, markers of bone formation (type I procollagen amino-terminal propeptide, OC, and bone-related alkaline phosphatase), and resorption (CTx and urinary type 1 collagen cross-linked N-telopeptide/creatinine ratio).	Creatinine	347-357	insulin like growth factor 1	Homo sapiens	26-31
14531820-16	2003	CONCLUSION: This study shows that (1) uPA and uPAR are up-regulated during acute renal allograft rejection; (2) uPAR levels in urine and serum correlate with serum creatinine levels, and (3) uPA and uPAR are produced by inflammatory cells, tubular epithelium, and vascular endothelium during acute renal allograft rejection.	Creatinine	164-174	plasminogen activator, urokinase	Homo sapiens	38-41
14579936-7	2003	CONCLUSION: Withdrawal of ACE inhibitor causes the deterioration of renal function in patients with the II or DI genotypes, high proteinuria after the withdrawal, and high serum creatinine level at the withdrawal, which probably causes the rebound increase in serum ACE activity.	Creatinine	178-188	angiotensin I converting enzyme	Homo sapiens	266-269
14579939-7	2003	In Group B patients, the annual change of creatinine clearance correlated inversely with the mean CRP concentration (r = -0.682, p &lt; 0.01).	Creatinine	42-52	C-reactive protein	Homo sapiens	98-101
14580157-9	2003	The Eex urinary insulin concentration was higher than expected, considering the circulation levels, but lower when compared with the expected concentration considering creatinine excretion.	Creatinine	168-178	insulin	Homo sapiens	16-23
14551679-10	2003	Patients with PAC/renin activity less than 2 had higher total volume of infused fluid, serum creatinine level, and fractional excretion of sodium values; aldosterone and serum creatinine were negatively correlated.	Creatinine	93-103	renin	Homo sapiens	18-23
14551679-10	2003	Patients with PAC/renin activity less than 2 had higher total volume of infused fluid, serum creatinine level, and fractional excretion of sodium values; aldosterone and serum creatinine were negatively correlated.	Creatinine	176-186	renin	Homo sapiens	18-23
14555823-7	2003	The lowest level of serum albumin was positively correlated with platelet count (r=0.505, p&lt;0.001) and was negatively correlated with leukocyte count (r=-0.329, p&lt;0.001), BUN (r=-0.484, p&lt;0.001), serum creatinine (r=-0.394, p&lt;0.001), and AST (r=-0.251, p=0.002).	Creatinine	211-221	albumin	Homo sapiens	20-33
14642117-12	2003	In comparison with the iARF group, the serum Cr level of the NF-kappaB decoy ODN treatment group was significantly lowered by 70% (79 micromol/L +/- 21 micromol/L vs. 256 micromol/L +/- 84 micromol/L, P &lt; 0.01), the renal tubular damage score was markedly lower (1.85 +/- 0.15 vs. 3.63 +/- 0.15 scores, P &lt; 0.01), and the M/MPhi infiltration and MCP-1 gene expression were inhibited.	Creatinine	45-47	mast cell protease 1-like 1	Rattus norvegicus	352-357
12968985-6	2003	A creatinine clearance of 30 ml min(-1) was associated with a decrease in enoxaparin clearance of 27% compared with that in a patient with a median creatinine clearance of 88 ml min-1, and was related to a 1.5- and 3.8-fold increase in the risk of "all" and "major" haemorrhagic episodes, respectively.	Creatinine	2-12	CD59 molecule (CD59 blood group)	Homo sapiens	32-38
12968985-6	2003	A creatinine clearance of 30 ml min(-1) was associated with a decrease in enoxaparin clearance of 27% compared with that in a patient with a median creatinine clearance of 88 ml min-1, and was related to a 1.5- and 3.8-fold increase in the risk of "all" and "major" haemorrhagic episodes, respectively.	Creatinine	2-12	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
12968985-6	2003	A creatinine clearance of 30 ml min(-1) was associated with a decrease in enoxaparin clearance of 27% compared with that in a patient with a median creatinine clearance of 88 ml min-1, and was related to a 1.5- and 3.8-fold increase in the risk of "all" and "major" haemorrhagic episodes, respectively.	Creatinine	148-158	CD59 molecule (CD59 blood group)	Homo sapiens	32-38
14531779-7	2003	Enrollment level of CRP was inversely correlated with nutritional markers prealbumin (r = -0.5, P &lt; 0.0001) and creatinine (r =-0.35, P &lt; 0.01).	Creatinine	115-125	C-reactive protein	Homo sapiens	20-23
12954376-8	2003	8-iso-PGF(2alpha) was determined to be 291+/-102 pg/mg creatinine by method A and 141+/-41 pg/mg creatinine by method B.	Creatinine	55-65	placental growth factor	Homo sapiens	6-9
14620929-7	2003	Renal dysfunction characterized by decreased creatinine clearance (C(cr)) was more severe in AM +/- after Ang II infusion.	Creatinine	45-55	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	106-112
12943889-0	2003	Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome.	Creatinine	20-30	C-reactive protein	Homo sapiens	40-58
14504195-5	2003	IGF-I, IGF-II, and IGF binding protein-3 were inversely associated with the presence of neonatal jaundice and blood creatinine, after controlling for blood protein levels.	Creatinine	116-126	insulin like growth factor 1	Homo sapiens	0-5
12859698-10	2003	Cytochrome c levels were correlated with serum bilirubin, alkaline phosphatase, creatinine levels, necroinflammatory score and apoptotic index, but not with serum alanine aminotransferase and synthetic liver function tests.	Creatinine	80-90	cytochrome c, somatic	Homo sapiens	0-12
12814480-5	2003	Multiple regression analyses indicated that the correlations between the early ELISPOT measurements of interferon-gamma and serum creatinine were independent of acute rejection, delayed graft function, or the presence of panel reactive antibodies before transplantation.	Creatinine	130-140	interferon gamma	Homo sapiens	103-119
12873291-7	2003	RESULTS: The insulin requirement of patients with Type 1 diabetes was reduced from 0.72 +/- 0.16 IU/kg per day at a creatinine clearance rate of 80 ml/min, to 0.45 +/- 0.13 IU/kg per day at a creatinine clearance rate of 10 ml/min (decrement of 38%, P &lt; 0.001).	Creatinine	116-126	insulin	Homo sapiens	13-20
12873291-7	2003	RESULTS: The insulin requirement of patients with Type 1 diabetes was reduced from 0.72 +/- 0.16 IU/kg per day at a creatinine clearance rate of 80 ml/min, to 0.45 +/- 0.13 IU/kg per day at a creatinine clearance rate of 10 ml/min (decrement of 38%, P &lt; 0.001).	Creatinine	192-202	insulin	Homo sapiens	13-20
12873291-8	2003	The insulin dose required by Type 2 diabetic patients was reduced from 0.68 +/- 0.28 IU/kg per day at a creatinine clearance rate of 80 ml/min to 0.33 +/- 0.19 IU/kg per day at a clearance rate of 10 ml/min (decrement 51%, P &lt; 0.001).	Creatinine	104-114	insulin	Homo sapiens	4-11
12911160-9	2003	The decline of urinary TGF-beta1 excretion followed that of serum creatinine.	Creatinine	66-76	transforming growth factor beta 1	Homo sapiens	23-32
12809563-3	2003	Mean creatinine was 5.0 +/- 1.8 mg/dL (Mean +/- SEM) when starting EPO at a weekly dose of 5000 +/- 500 units once the hematocrit was below 30 %.	Creatinine	5-15	erythropoietin	Homo sapiens	67-70
12809563-9	2003	When linear regression analysis was applied to pre- and post-EPO 1/creatinine data the mean rate of decline was -0.0140 +/- 0.0119 (mean +/- SD) and -0.0017 +/- 0.0090 (non-parametric Wilcoxon matched pairs signed rank sum test: Z value: -2.91; P = 0.004) respectively.	Creatinine	67-77	erythropoietin	Homo sapiens	61-64
14592564-8	2003	In the CAD group plasma adiponectin concentration correlated with levels of creatinine (r=0.56; p&lt;0.001), HDL cholesterol (r=0.24; p&lt;0.05), BMI (r=-0.33; p&lt;0.001), glucose (r=-0.22; p&lt;0.05) and triglycerides (r=-0.25; p&lt;0.05).	Creatinine	76-86	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35
12753264-9	2003	The independent predictors for PTH were 25-hydroxyvitamin D and serum creatinine in both sexes, but age was a predictor only in men.	Creatinine	70-80	parathyroid hormone	Homo sapiens	31-34
12827563-9	2003	Presence of serum creatinine &gt; 1.2 mg/dL at any time before liver transplantation and a baseline GFR &lt;70 mL/min/1.73 m(2) were independent predictors of permanent renal dysfunction.	Creatinine	18-28	CD59 molecule (CD59 blood group)	Homo sapiens	114-119
14682206-9	2003	The group of MM patients with renal failure (creatinine level &gt; 2 mg%) had higher VEGF level than those with normal renal function: mean 199.9 pg/ml, SD = 235, and mean 46.9 SD = 47 respectively, p &lt; 0.01.	Creatinine	45-55	vascular endothelial growth factor A	Homo sapiens	85-89
12775957-11	2003	The insulin resistance associated parameters, such as waist and neck circumferences, abdominal obesity measured by waist-to-hip ratio, mean insulin concentration (11.3 mU/l versus 9.95 mU/l, p=0.02) or urinary albumin-to-creatinine ratio (1.80 versus 1.58, p=0.01), were significantly higher in women with extensive hair loss compared to those with normal hair or only minimal hair loss (grade I on Ludwig"s scale).	Creatinine	221-231	insulin	Homo sapiens	4-11
12748357-14	2003	Thus, the nature of the correlation between CRP and serum creatinine changes with increasing CRP values: from being a direct one, it shows a trend towards a transformation into an indirect one with beta=0 at a CRP value of approximately 9 mg/l.	Creatinine	58-68	C-reactive protein	Homo sapiens	93-96
12753284-6	2003	RESULTS: Serum PTH was slightly elevated in 10 patients (83%) in group A. Serum PTH levels were positively related to serum calcium, osteocalcin, BAP, telopeptide, OH-proline, and creatinine.	Creatinine	180-190	parathyroid hormone	Homo sapiens	80-83
12746780-6	2003	According to these results, monitoring of creatinine clearance, especially in patients with a low nadir CD4+ T lymphocyte count, could lead to modifications in antiretroviral therapy in order to diminish the risk of occurrence of lactic acidosis.	Creatinine	42-52	CD4 molecule	Homo sapiens	104-107
12748357-12	2003	Stratifying the patients for the effects of CRP, only CRP values &lt;/=4 mg/l were directly predictive of serum creatinine (P&lt;0.00001), whereas CRP values &gt;4 mg/l were not.	Creatinine	112-122	C-reactive protein	Homo sapiens	54-57
12748357-12	2003	Stratifying the patients for the effects of CRP, only CRP values &lt;/=4 mg/l were directly predictive of serum creatinine (P&lt;0.00001), whereas CRP values &gt;4 mg/l were not.	Creatinine	112-122	C-reactive protein	Homo sapiens	54-57
12748357-14	2003	Thus, the nature of the correlation between CRP and serum creatinine changes with increasing CRP values: from being a direct one, it shows a trend towards a transformation into an indirect one with beta=0 at a CRP value of approximately 9 mg/l.	Creatinine	58-68	C-reactive protein	Homo sapiens	44-47
12748357-14	2003	Thus, the nature of the correlation between CRP and serum creatinine changes with increasing CRP values: from being a direct one, it shows a trend towards a transformation into an indirect one with beta=0 at a CRP value of approximately 9 mg/l.	Creatinine	58-68	C-reactive protein	Homo sapiens	93-96
12748357-16	2003	CONCLUSIONS: The present cross-sectional study suggests that the activation of acute phase response does not influence creatinine metabolism in haemodialysis patients; in contrast, age, Kt/V and nPCR predict serum creatinine levels.	Creatinine	214-224	nasopharyngeal carcinoma-related protein	Homo sapiens	195-199
12686661-8	2003	In multivariate analyses, creatinine clearance was an independent determinant of the endothelial function score (beta=-0.34, P=0.006), plasma vWf (beta=-0.37, P=0.022) and sICAM-1 (beta=-0.33, P=0.012).	Creatinine	26-36	von Willebrand factor	Homo sapiens	142-145
12708564-5	2003	Urinary transferrin was measured by sandwich ELISA and correlated with rate of change in estimated creatinine clearance (ECC).	Creatinine	99-109	transferrin	Homo sapiens	8-19
12663585-7	2003	C-peptide-to-creatinine ratio correlated positively with EDD and NO and negatively with vWF and DDF.	Creatinine	13-23	von Willebrand factor	Homo sapiens	88-91
12427649-6	2002	8-Iso-PGF(2alpha) was significantly reduced by simvastatin, from 361+/-148 pg/mg creatinine (mean+/-SD) at baseline to 239+/-124 pg/mg creatinine after 1 month.	Creatinine	81-91	placental growth factor	Homo sapiens	6-9
12766604-12	2003	In patients without criteria of glomerular hyperfiltration, plasma level and clearance of creatinine were 128+/-33 micromol.l-1 and 56+/-15 ml.min-1, respectively; and in those patients with glomerular hyperfiltration criteria were 108+/-18 micromol.l-1 (P=NS) and 83+/-24 ml.min-1 (P=0.002) respectively.	Creatinine	90-100	CD59 molecule (CD59 blood group)	Homo sapiens	143-148
12704481-7	2003	Multivariate predictors of ACE inhibitor usage were serum creatinine, male sex, peripheral edema and increasing serum glucose.	Creatinine	58-68	angiotensin I converting enzyme	Homo sapiens	27-30
12603501-8	2003	The date of dialysis was predicted from the least squares linear regression formula and a target serum creatinine level cor- responding to estimated creatinine clearance of 7 mL min-1, at which dialysis was recommended.	Creatinine	103-113	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
12603501-8	2003	The date of dialysis was predicted from the least squares linear regression formula and a target serum creatinine level cor- responding to estimated creatinine clearance of 7 mL min-1, at which dialysis was recommended.	Creatinine	149-159	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
12707994-6	2003	Notably only urinary L-FABP at the start of follow-up (F = 17.1) was selected as a significant clinical factor correlated with the progression rate defined as a slope of a reciprocal of serum creatinine over time.	Creatinine	192-202	fatty acid binding protein 1	Homo sapiens	21-27
12552499-8	2003	However, frequencies of IL4 B1 allele and B1/B1 genotype in patients with progressive IgA nephropathy (end-stage renal disease or doubling of serum creatinine level; n = 34) were significantly greater than corresponding values in the nonprogression group (n = 62; 79% versus 61%; P &lt; 0.01 and 59% versus 34%; P &lt; 0.05, respectively).	Creatinine	148-158	interleukin 4	Homo sapiens	24-27
12631131-3	2003	METHODS: To test this hypothesis, we studied the relationship between CRP levels and renal function loss measured as diminished creatinine clearance in a large non-diabetic population (7317 subjects).	Creatinine	128-138	C-reactive protein	Homo sapiens	70-73
12631131-16	2003	However, the association between CRP, body weight, and a relatively elevated creatinine clearance is a hypothesis-generating finding, suggesting that early inflammatory processes related to high body fat may predispose the kidney to glomerular hyperfiltration-related renal function loss.	Creatinine	77-87	C-reactive protein	Homo sapiens	33-36
12857466-6	2003	Serum SOD, GSH-Px and MDA concentrations in 36 non-dialyzed patients with various degrees were also correlated with creatinine clearance (r(G)=0.68, P&lt;0.01; r(M)=-0.52, P&lt;0.01; r(S)=-0.44, P&lt;0.05).	Creatinine	116-126	superoxide dismutase 1	Homo sapiens	6-9
12592643-11	2003	The urinary TGF-beta excretion (pg/mg urinary creatinine) was 48.6 +/- 5.9 in control animals, 603.9 +/- 80.41 in untreated diabetic rats, 279.3 +/- 47.0 in diabetic rats treated with enalapril, and 243.7 +/- 40.0 in rats treated with losartan.	Creatinine	46-56	transforming growth factor, beta 1	Rattus norvegicus	12-20
15160549-4	2003	RESULTS: The administration of EPO was associated with an increased serum creatinine (11.9 +/- 0.4 to 12.5 +/- 0.4 mg/dl, p &lt; 0.05), insulin-like growth factor binding protein (3.0 +/- 0.2 to 3.4 +/- 0.2 micrograms/ml, p &lt; 0.05) as well as decreased iron level (112 +/- 7 to 88 +/- 7 micrograms/dl, p &lt; 0.005).	Creatinine	74-84	erythropoietin	Homo sapiens	31-34
12753883-1	2003	Many clinicians are uncomfortable about using angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (AT(1)-blockers) to treat patients with renal disease because of concerns about increasing serum creatinine levels.	Creatinine	233-243	angiotensin I converting enzyme	Homo sapiens	46-75
12753883-1	2003	Many clinicians are uncomfortable about using angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (AT(1)-blockers) to treat patients with renal disease because of concerns about increasing serum creatinine levels.	Creatinine	233-243	angiotensin I converting enzyme	Homo sapiens	77-80
12722139-2	2003	When rats were given intravenous lipopolysaccharide and tested 6 h later we found that the activities of catalase and glutathione peroxidase (GSH-Px) in kidney, were acutely suppressed while in serum the levels of nitric oxide (NO), lipid peroxidation, urea nitrogen and creatinine were significantly increased, indicating the excessive production of reactive oxygen radicals and the presence of renal injury.	Creatinine	271-281	catalase	Rattus norvegicus	105-113
12631094-10	2003	A positive linear relationship was found between cNOS activity in cortex and creatinine clearance.	Creatinine	77-87	nitric oxide synthase 3	Homo sapiens	49-53
12610747-5	2003	RESULTS: Among patients receiving ACE inhibitors, serum creatinine levels increased in 22% of participants who were dispensed calcium antagonists, and in 31% of other patients (P=0.005).	Creatinine	56-66	angiotensin I converting enzyme	Homo sapiens	34-37
15315013-11	2003	The urinary excretion of NAG and alpha-1M was estimated in the second morning portion of urine and it was presented as NAG/creatinine and alpha-1M/creatinine ratio.	Creatinine	123-133	N-acetyl-alpha-glucosaminidase	Homo sapiens	25-28
15315013-11	2003	The urinary excretion of NAG and alpha-1M was estimated in the second morning portion of urine and it was presented as NAG/creatinine and alpha-1M/creatinine ratio.	Creatinine	147-157	N-acetyl-alpha-glucosaminidase	Homo sapiens	25-28
12518171-2	2003	We have previously reported that after 8 weeks of oral therapy with H1-A, 40 microg/kg/day, MRL lpr/lpr mice demonstrated significantly less proteinuria, lower serum creatinine levels, and less renal mesangial proliferation than mice in an untreated group.	Creatinine	166-176	Fas (TNF receptor superfamily member 6)	Mus musculus	100-103
12427649-6	2002	8-Iso-PGF(2alpha) was significantly reduced by simvastatin, from 361+/-148 pg/mg creatinine (mean+/-SD) at baseline to 239+/-124 pg/mg creatinine after 1 month.	Creatinine	135-145	placental growth factor	Homo sapiens	6-9
12187088-5	2002	RESULTS: The urinary L-PGDS index increased in diabetic patients, compared with the controls (234.8 +/- 27.4 vs. 73.8 +/- 7.8 microg/mmol Cr, p &lt; 0.001).	Creatinine	138-140	prostaglandin D2 synthase	Homo sapiens	21-27
12472776-6	2003	RESULTS: Pre-ischemic treatment with the C5a receptor (C5aR) antagonist (1 mg/kg IV or 10 mg/kg PO) substantially inhibited or prevented I/R-induced hematuria, vascular leakage, tissue levels of TNF-alpha and MPO, and serum levels of AST and creatinine.	Creatinine	242-252	complement C5a receptor 1	Rattus norvegicus	41-53
12472776-6	2003	RESULTS: Pre-ischemic treatment with the C5a receptor (C5aR) antagonist (1 mg/kg IV or 10 mg/kg PO) substantially inhibited or prevented I/R-induced hematuria, vascular leakage, tissue levels of TNF-alpha and MPO, and serum levels of AST and creatinine.	Creatinine	242-252	complement C5a receptor 1	Rattus norvegicus	55-59
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	coagulation factor II, thrombin	Homo sapiens	121-129
12411460-5	2002	Adrenomedullin also significantly enhanced urinary sodium excretion (day 4, 3-fold; P&lt;0.05), creatinine excretion (1.2-fold; P&lt;0.001), and creatinine clearance (1.4-fold; P&lt;0.001) over the 4 days of treatment, whereas urine volume and cAMP excretion tended to be elevated (both, 0.1&gt;P&gt;0.05).	Creatinine	96-106	pro-adrenomedullin	Ovis aries	0-14
12411460-5	2002	Adrenomedullin also significantly enhanced urinary sodium excretion (day 4, 3-fold; P&lt;0.05), creatinine excretion (1.2-fold; P&lt;0.001), and creatinine clearance (1.4-fold; P&lt;0.001) over the 4 days of treatment, whereas urine volume and cAMP excretion tended to be elevated (both, 0.1&gt;P&gt;0.05).	Creatinine	145-155	pro-adrenomedullin	Ovis aries	0-14
12397045-7	2002	The plasma GH concentration was significantly correlated with the plasma N-IR and the C-IR, as well as with the serum creatinine level.	Creatinine	118-128	growth hormone 1	Homo sapiens	11-13
12961001-15	2002	EPO correlated negatively with creatinine concentration (r=-0.768) and positively with creatinine clearance (r=0.769) in patients with 1st DOD.	Creatinine	31-41	erythropoietin	Homo sapiens	0-3
12961001-15	2002	EPO correlated negatively with creatinine concentration (r=-0.768) and positively with creatinine clearance (r=0.769) in patients with 1st DOD.	Creatinine	87-97	erythropoietin	Homo sapiens	0-3
12556068-17	2002	Positive correlation between TGFbeta1 concentration and dialysate-to-plasma ratio for creatinine in PET (R = 0.35, p &lt; 0.05) was found.	Creatinine	86-96	transforming growth factor beta 1	Homo sapiens	29-37
12621778-9	2002	After one-year-observation of patients with type II diabetes mellitus it was established that the increase of serum creatinine concentrations values were higher in those patients, whose initial TGF-beta 1 levels exceeded normal values.	Creatinine	116-126	transforming growth factor beta 1	Homo sapiens	194-204
12621778-10	2002	A positive correlation between urine TGF-beta 1 level and the progression of renal failure measured by the increase of serum creatinine level was observed.	Creatinine	125-135	transforming growth factor beta 1	Homo sapiens	37-47
12392842-11	2002	Urocortin produced dose-dependent, sustained increases in urine volume (twofold, p &lt; 0.01), sodium excretion (&gt;9-fold rise, p &lt; 0.001), and creatinine clearance (p &lt; 0.001) in HF sheep.	Creatinine	149-159	urocortin	Ovis aries	0-9
12352362-12	2002	creatinine as a cutoff between obstruction and no obstruction, TGF-beta1 was 80% sensitive, 82% specific and 81% accurate for the diagnosis of obstruction.	Creatinine	0-10	transforming growth factor beta 1	Homo sapiens	63-72
12200796-8	2002	Serum creatinine levels correlated with 3DG and erythrocyte AR levels in the control and CRF groups (3DG: r = 0.67; P &lt; 0.001; erythrocyte AR: r = 0.71; P &lt; 0.001).	Creatinine	6-16	aldo-keto reductase family 1 member B	Homo sapiens	60-62
12200796-8	2002	Serum creatinine levels correlated with 3DG and erythrocyte AR levels in the control and CRF groups (3DG: r = 0.67; P &lt; 0.001; erythrocyte AR: r = 0.71; P &lt; 0.001).	Creatinine	6-16	aldo-keto reductase family 1 member B	Homo sapiens	142-144
12500664-4	2002	Pearson product-moment correlation analysis showed that with increase of the concentration of blood creatinine as well as prolongation of the course of disease in the CGNP, the concentrations of NO in plasma, and LPO in plasma and erythrocytes in the CGNP increased gradually, while the concentrations of VC, VE and beta-CAR in plasma as well as the activities of SOD, CAT and GPX in erythrocytes in the CGNP decreased gradually (P = 0.002454-0.000001).	Creatinine	100-110	catalase	Homo sapiens	369-372
12194921-8	2002	Urinary L-PGDS excretion was significantly increased in patients with diabetic nephropathy, IgA nephropathy, and chronic glomerulonephritis even when serum creatinine was not increased.	Creatinine	156-166	prostaglandin D2 synthase	Homo sapiens	8-14
12194921-9	2002	In patients with renal diseases, urinary L-PGDS was correlated with urinary albumin (r = 0.64; P &lt;0.0001), N-acetyl-beta-D-glucosaminidase (r = 0.43; P &lt;0.001), and serum creatinine (r = 0.66; P &lt;0.0001).	Creatinine	177-187	prostaglandin D2 synthase	Homo sapiens	41-47
12213868-8	2002	There were significant increases in surrogate markers of bone turnover in subjects with AN compared with controls as assessed by osteocalcin (AN, 0.9 +/- 0.4 micro g/liter.month, vs. control, -1.1 +/- 0.4 micro g/liter.month; P = 0.0007), bone-specific alkaline phosphatase (AN, 0.6 +/- 0.5 U/liter.month, vs. control, -1.5 +/- 0.4 U/liter.month; P = 0.002), deoxypyridinoline [AN, 0.1 +/- 0.1 nmol/mmol creatinine (cr).month, vs. control, -0.4 +/- 0.1 nmol/mmol cr.month; P = 0.005], and N-telopeptide (AN, 4 +/- 4 nmol BCE/mmol cr/month, vs. control, -9 +/- 4 nmol BCE/mmol cr/month; P = 0.01).	Creatinine	25-27	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
12187088-6	2002	Even in normoalbuminuric patients as well as in microalbuminuric patients, urinary L-PGDS indexes were higher than the controls (166.0 +/- 21.1, p &lt; 0.0001 and 338.6 +/- 62.5 microg/mmol Cr, p &lt; 0.0001, respectively), although the serum L-PGDS level was equal to that in the control subjects.	Creatinine	190-192	prostaglandin D2 synthase	Homo sapiens	83-89
12187088-8	2002	Glycemic control reduced the urinary L-PGDS index towards the normal range in diabetic patients with normoalbuminuria (172.3 +/- 6.6 vs. 118.1 +/- 2.6 (SE) microg/mmol Cr, p &lt; 0.0001).	Creatinine	168-170	prostaglandin D2 synthase	Homo sapiens	37-43
12169762-4	2002	AII-infused rats displayed a decreased creatinine clearance (538 +/- 75 vs. 898 +/- 96 ml/min) and hypertrophic left ventricles (0.275 +/- 0.006 vs. 0.220 +/- 0.011 g/100 g).	Creatinine	39-49	angiotensinogen	Rattus norvegicus	0-3
12474568-0	2002	[The effect of recombinant human growth hormone on urea and creatinine kinetics and selected dialysis adequacy parameters in children with end-stage renal failure treated with peritoneal dialysis].	Creatinine	60-70	growth hormone 1	Homo sapiens	33-47
12474568-1	2002	UNLABELLED: The aim of this work was to assess the effect of recombinant human growth hormone (rhGH) on the kinetics of urea and creatinine and selected indices of dialysis adequacy in children with end-stage renal failure treated with peritoneal dialysis.	Creatinine	129-139	growth hormone 1	Homo sapiens	79-93
12187289-5	2002	The plasma ET-1 concentrations were correlated with the mean blood pressure, creatinine clearance, and severity of portal hypertension, as measured by portal flow volume and portal flow velocity.	Creatinine	77-87	endothelin 1	Homo sapiens	11-15
12187289-9	2002	Plasma ET-1 concentrations correlated positively with the mean blood pressure ( = 0.58; &lt; 0.05) and negatively with renal function, as measured by creatinine clearance ( = -0.7; &lt;0.005).	Creatinine	150-160	endothelin 1	Homo sapiens	7-11
12131289-8	2002	RESULTS: The optimal threshold values for NMP22, fibronectin and UBC were calculated by receiver operator characteristics curves as 27 units per mg. creatinine, 198 mg./mg.	Creatinine	149-159	nuclear mitotic apparatus protein 1	Homo sapiens	42-47
12138260-16	2002	CONCLUSIONS: IL-6 and CRP were increased and were inversely related to creatinine clearance in our population of 103 chronic predialytic patients.	Creatinine	71-81	interleukin 6	Homo sapiens	13-17
12138260-16	2002	CONCLUSIONS: IL-6 and CRP were increased and were inversely related to creatinine clearance in our population of 103 chronic predialytic patients.	Creatinine	71-81	C-reactive protein	Homo sapiens	22-25
12476894-9	2002	After one-year-observation of patients with type 2 diabetes mellitus it was established that the increase of serum creatinine concentration and that of microalbuminuria value were higher in those patients, whose initial TGF beta 1 levels exceeded normal values.	Creatinine	115-125	transforming growth factor beta 1	Homo sapiens	220-230
12476894-10	2002	A positive correlation between urine TGF beta 1 level and the progression of renal failure measured by the increase of serum creatinine level was observed.	Creatinine	125-135	transforming growth factor beta 1	Homo sapiens	37-47
12199967-7	2002	RESULTS: U-EPX concentrations were significantly higher in all asthmatic children during attacks (139.6 11.7 microg/mmol of creatinine) than those in the control group (35.3 6.2 microg/mmol of creatinine) (p &lt; 0.001).	Creatinine	124-134	eosinophil peroxidase	Homo sapiens	11-14
12199967-7	2002	RESULTS: U-EPX concentrations were significantly higher in all asthmatic children during attacks (139.6 11.7 microg/mmol of creatinine) than those in the control group (35.3 6.2 microg/mmol of creatinine) (p &lt; 0.001).	Creatinine	193-203	eosinophil peroxidase	Homo sapiens	11-14
12199967-8	2002	Two weeks after resolution of the exacerbation, U-EPX significantly decreased (66.5 9.3 microg/mmol of creatinine) (p &lt; 0.001).	Creatinine	103-113	eosinophil peroxidase	Homo sapiens	50-53
12199967-9	2002	U-EPX concentrations were highest in patients with severe attacks (191.5 11.3 microg/mmol of creatinine) (p &lt; 0.001).	Creatinine	93-103	eosinophil peroxidase	Homo sapiens	2-5
12218650-1	2002	The authors investigated the effect of renal function on plasma amyloid beta protein (Abeta) by analyzing the relationship between creatinine (Cr) and Abeta40 or Abeta42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients.	Creatinine	131-141	amyloid beta precursor protein	Homo sapiens	86-91
12218650-4	2002	These results indicate that it may be useful to consider Cr levels when measuring plasma Abeta.	Creatinine	57-59	amyloid beta precursor protein	Homo sapiens	89-94
12133029-1	2002	PURPOSE: To determine the association between the early rise in serum creatinine levels associated with the use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) and the long-term renoprotective properties of these drugs in patients with chronic renal insufficiency.	Creatinine	70-80	angiotensin I converting enzyme	Homo sapiens	146-149
12455716-7	2002	In hypertensive patients, plasma ADPN was inversely related to creatinine clearance and tended to be inversely related to serum insulin (r= -0.27) and HOMA-R index (r= -0.24).	Creatinine	63-73	adiponectin, C1Q and collagen domain containing	Homo sapiens	33-37
12455716-8	2002	The relationship between plasma ADPN and renal function was confirmed in a multiple regression analysis which showed that creatinine clearance was the only independent predictor of plasma ADPN.	Creatinine	122-132	adiponectin, C1Q and collagen domain containing	Homo sapiens	32-36
12455716-8	2002	The relationship between plasma ADPN and renal function was confirmed in a multiple regression analysis which showed that creatinine clearance was the only independent predictor of plasma ADPN.	Creatinine	122-132	adiponectin, C1Q and collagen domain containing	Homo sapiens	188-192
12111177-8	2002	Preoperative creatinine clearances in the normal, temporary, and persistent groups were 94.25+/-27.47, 95.19+/-18.63, and 69.18+/-16.18 ml/min/1.73 m(2), respectively, being significantly lower in the persistent group ( P&lt;0.05).	Creatinine	13-23	CD59 molecule (CD59 blood group)	Homo sapiens	139-144
12111177-9	2002	In this group, patients with creatinine clearances less than 70 ml/min/1.73 m(2) could not compensate for metabolic acidosis.	Creatinine	29-39	CD59 molecule (CD59 blood group)	Homo sapiens	67-72
12451679-11	2002	cTnT(qualitative) showed false positive results in 22/28 with serum creatinine over 2.1 mg/dl due to renal failure.	Creatinine	68-78	troponin T2, cardiac type	Homo sapiens	0-4
12133029-26	2002	Patients with chronic renal insufficiency (serum creatinine&gt;1.5 mg/dL) who received therapy with ACE inhibitors had about a five times higher risk of developing hyperkalemia than those with normal renal function, whereas presence of heart failure increased the risk of hyperkalemia by about three times over those without heart failure.	Creatinine	49-59	angiotensin I converting enzyme	Homo sapiens	100-103
12133029-28	2002	CONCLUSION: The authors conclude that, in patients with renal insufficiency (serum creatinine&gt;1.4 mg/dL) treated with ACE inhibitors, there is a strong association between early (within the first 2 months) and moderate (not exceeding 30% over baseline) rise in serum creatinine and slowing of the renal disease progression in the long run.	Creatinine	83-93	angiotensin I converting enzyme	Homo sapiens	121-124
12133029-28	2002	CONCLUSION: The authors conclude that, in patients with renal insufficiency (serum creatinine&gt;1.4 mg/dL) treated with ACE inhibitors, there is a strong association between early (within the first 2 months) and moderate (not exceeding 30% over baseline) rise in serum creatinine and slowing of the renal disease progression in the long run.	Creatinine	270-280	angiotensin I converting enzyme	Homo sapiens	121-124
12046038-7	2002	Conversely, multivariate analysis showed that PTH levels at entry were associated directly with creatinine levels and inversely with age and ionized calcium levels (but not diabetes).	Creatinine	96-106	parathyroid hormone	Homo sapiens	46-49
12046038-10	2002	Interestingly, time-dependent PTH levels were independently associated with survival after adjusting for traditional risk factors (diabetes, age, albumin and creatinine levels, and URR) and duration of dialysis therapy.	Creatinine	158-168	parathyroid hormone	Homo sapiens	30-33
12133029-4	2002	In fact, patients who have the most advanced renal insufficiency at baseline are the ones who show the maximum slowing of the disease progression, but these patients are also more likely to show an early rise in serum creatinine levels after ACE inhibitor therapy.	Creatinine	218-228	angiotensin I converting enzyme	Homo sapiens	242-245
12133029-7	2002	One of the main reasons for this underutilization of ACE inhibitors in patients with heart failure is the underlying renal insufficiency or the rise in serum creatinine level after initiation of therapy with an ACE inhibitor.	Creatinine	158-168	angiotensin I converting enzyme	Homo sapiens	53-56
12133029-7	2002	One of the main reasons for this underutilization of ACE inhibitors in patients with heart failure is the underlying renal insufficiency or the rise in serum creatinine level after initiation of therapy with an ACE inhibitor.	Creatinine	158-168	angiotensin I converting enzyme	Homo sapiens	211-214
12133029-17	2002	RESULTS: Patients with preexisting chronic renal insufficiency who achieved their blood pressure control goals were likely to demonstrate an early rise in serum creatinine levels, approximately 25% above the baseline (approximately 1.7 mg/dL) after initiation of ACE inhibitor or ARB therapy.	Creatinine	161-171	angiotensin I converting enzyme	Homo sapiens	263-266
12133029-25	2002	Serum creatinine levels in these patients sharply increased (by approximately 75% above baseline) in the 2 weeks after the initiation of therapy with an ACE inhibitor, followed by an even sharper increase (another approximately 150%) during the subsequent 2 weeks.	Creatinine	6-16	angiotensin I converting enzyme	Homo sapiens	153-156
12069449-4	2002	RESULTS: Cox proportional-hazards model demonstrated that the unadjusted risk ratio associated with a calculated creatinine clearance &lt; or =40 ml x min(-1) compared to a clearance above 85 ml x min(-1) was 7.1 (95% confidence interval 6.2-8.0).	Creatinine	113-123	CD59 molecule (CD59 blood group)	Homo sapiens	151-157
12003699-7	2002	Therefore, as of this writing, all patients with type 2 diabetes and no evidence of nephropathy, ie, proteinuria and an elevated creatinine &gt; 1.5 mg/dL, should be placed on an ACE inhibitor for cardiovascular risk reduction.	Creatinine	129-139	angiotensin I converting enzyme	Homo sapiens	179-182
12069449-4	2002	RESULTS: Cox proportional-hazards model demonstrated that the unadjusted risk ratio associated with a calculated creatinine clearance &lt; or =40 ml x min(-1) compared to a clearance above 85 ml x min(-1) was 7.1 (95% confidence interval 6.2-8.0).	Creatinine	113-123	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
12050247-8	2002	The slightly positive correlation between adiponectin and age, blood urea nitrogen, or creatinine levels was also observed (all P &lt; 0.001).	Creatinine	87-97	adiponectin, C1Q and collagen domain containing	Homo sapiens	42-53
12032189-5	2002	RESULTS: Circulating levels of tenascin and TIMP-1 were moderately, but significantly, higher in patients with chronic renal disease (n=54; mean creatinine clearance, 62 ml/min) than in healthy controls (n=176).	Creatinine	145-155	TIMP metallopeptidase inhibitor 1	Homo sapiens	44-50
11873030-8	2002	Similarly, creatinine clearance did not change in the norepinephrine group but increased by 75% in the vasopressin group (P &lt; 0.05).	Creatinine	11-21	arginine vasopressin	Homo sapiens	103-114
11961395-7	2002	RESULTS: Plasma orexin A concentrations were significantly higher in the HD group than in the control group and showed a significant correlation with serum creatinine.	Creatinine	156-166	hypocretin neuropeptide precursor	Rattus norvegicus	16-24
11961395-8	2002	In all subjects, there was a positive correlation between the plasma orexin A concentration and the serum creatinine concentration, but there were no correlations between these concentrations in each group.	Creatinine	106-116	hypocretin neuropeptide precursor	Rattus norvegicus	69-77
11961395-9	2002	In the HD group, plasma orexin A concentrations had a significant positive correlation with the serum albumin concentration and percent creatinine generation rate (%CGR).	Creatinine	136-146	hypocretin neuropeptide precursor	Rattus norvegicus	24-32
12102480-5	2002	RESULTS: The urinary soluble VCAM-1 level was significantly higher in patients with SLE compared to normal controls (32.35+/-34.27 vs. 4.66+/-3.8 ng/mg creatinine, p = 0.0005) and statistically significantly correlated with disease activity (SLEDAI), a low serum C3 level, decreased creatinine clearance and albuminuria, as well as with disease damage (SLICC/ACR damage index).	Creatinine	152-162	vascular cell adhesion molecule 1	Homo sapiens	29-35
12102480-5	2002	RESULTS: The urinary soluble VCAM-1 level was significantly higher in patients with SLE compared to normal controls (32.35+/-34.27 vs. 4.66+/-3.8 ng/mg creatinine, p = 0.0005) and statistically significantly correlated with disease activity (SLEDAI), a low serum C3 level, decreased creatinine clearance and albuminuria, as well as with disease damage (SLICC/ACR damage index).	Creatinine	283-293	vascular cell adhesion molecule 1	Homo sapiens	29-35
12086355-13	2002	NTx and osteocalcin levels were higher in FD patients compared with controls (400 +/- 338 vs 303 +/- 308, BCE/mM creatinine p < 0.02; 90 +/- 59.5 vs 61.8 +/- 36.9 ng/ml, p < 0.001, respectively).	Creatinine	113-123	bone gamma-carboxyglutamate protein	Homo sapiens	8-19
11920342-1	2002	We previously reported that the percentage of change in inverse serum creatinine (Delta1/Cr) was the best of several time-dependent serum creatinine-derived predictors of renal allograft failure in patients not administered cyclosporine (CsA).	Creatinine	70-80	delta like non-canonical Notch ligand 1	Homo sapiens	82-91
11920342-1	2002	We previously reported that the percentage of change in inverse serum creatinine (Delta1/Cr) was the best of several time-dependent serum creatinine-derived predictors of renal allograft failure in patients not administered cyclosporine (CsA).	Creatinine	138-148	delta like non-canonical Notch ligand 1	Homo sapiens	82-91
11920342-4	2002	A time-dependent covariate determined by the date of first chronic decline (excluding creatinine levels from periods of acute rejection) in Delta1/Cr to less than -30% of baseline similarly was predictive of graft failure in 101 patients treated without CsA (relative risk, 5.04; 95% confidence interval, 2.18 to 11.6; P = 0.0002) and 100 patients treated with CsA (relative risk, 5.02; 95% confidence interval, 2.50 to 10.1; P &lt; 0.0001).	Creatinine	86-96	delta like non-canonical Notch ligand 1	Homo sapiens	140-149
11920342-5	2002	A limited creatinine-sampling strategy (measured at 1 week, 1, 3, 6, 12, 18, 24, and 36 months, and each year thereafter) reduced the ability of Delta1/Cr less than -30% to predict graft failure.	Creatinine	10-20	delta like non-canonical Notch ligand 1	Homo sapiens	145-154
11877567-9	2002	At baseline, urinary TGF-beta1 levels were significantly increased in the study population compared with healthy controls (13.2 +/- 1.2 versus 1.7 +/- 1.1 ng/g creatinine; P &lt; 0.001).	Creatinine	160-170	transforming growth factor beta 1	Homo sapiens	21-30
11882588-10	2002	Serum levels of L-PGDS increased with the renal function worsened and positively correlated with serum creatinine, particularly in patients with renal impairments (r=0.76, P&lt;0.0001).	Creatinine	103-113	prostaglandin D2 synthase	Homo sapiens	16-22
11869929-8	2002	Urinary NAG (U/gr creatinine) (4.71 +/- 2.11) was lower than the battery workers (7.39 +/- 4.37), however significantly higher than the normal control group (3.07 +/- 1.20).	Creatinine	18-28	N-acetyl-alpha-glucosaminidase	Homo sapiens	8-11
11883653-3	2002	Two approaches for endcapping are possible for this synthetic method that produces a silica hydride intermediate: bonding of TMCS-HMDS after silanization (on the hydride intermediate) or after hydrosilation (on the C18 product stationary phase).	Creatinine	92-99	Bardet-Biedl syndrome 9	Homo sapiens	215-218
11840382-11	2002	In contrast, the percent increase in the Alb-to-Cr ratio in group 3 relative to that in group 2 was the highest, followed by percent increases in the TP-to-Cr, NAG-to-Cr, beta2MG-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	48-50	albumin	Homo sapiens	41-44
11805176-6	2002	Multiple linear regression analysis identified renal function parameters (GFR, creatinine, and urea) as the most important determinants of apoA-IV levels in serum of these patients.	Creatinine	79-89	apolipoprotein A4	Homo sapiens	139-146
11823573-6	2002	Plasma and urine concentrations of 8-iso-PGF(2 alpha) in nonsmoking individuals were 1.25 +/- 0.19 nmol/L and 272 +/- 53 pmol/mmol of creatinine, respectively.	Creatinine	134-144	placental growth factor	Homo sapiens	41-44
11862160-9	2002	TNF-a concentration was also increased by endotoxin; the changes are positively correlated with BUN and creatinine.	Creatinine	104-114	tumor necrosis factor	Rattus norvegicus	0-5
11845881-10	2002	In all patients, postoperative IL-6 levels were positively correlated with duration of inotropic support and serum creatinine value and inversely correlated with oxygenation index and diuresis.	Creatinine	115-125	interleukin 6	Homo sapiens	31-35
11940298-8	2002	The expression of TIMP-1 was distinctly associated with the level of serum creatinine (P &lt; 0.05), tubulointerstitial fibrosis (P &lt; 0.01), and tubulointerstitial infiltration of leukocytes (P &lt; 0.01).	Creatinine	75-85	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-24
11848304-4	2002	Each dose of FTS (Group A) partially elevated renal creatinine clearances.	Creatinine	52-62	AKT interacting protein	Rattus norvegicus	13-16
11848304-8	2002	A significant positive correlation was found between CAT activity and creatinine clearance.	Creatinine	70-80	catalase	Rattus norvegicus	53-56
12465743-3	2002	In a cross-sectional manner we determined serum EPO in 280 patients with anemia and normal serum concentrations of creatinine and urea.	Creatinine	115-125	erythropoietin	Homo sapiens	48-51
12077495-8	2002	The IGF-1 levels were positively correlated with creatinine clearance (r = 0.7066, p &lt; 0.01) and serum transferrin concentration (r = 0.5347, p &lt; 0.05).	Creatinine	49-59	insulin like growth factor 1	Homo sapiens	4-9
11897212-8	2002	In univariate analysis, age, serum creatinine, fasting insulin, and triglyceride levels correlated inversely with insulin sensitivity (p &lt;0.05 for all).	Creatinine	35-45	insulin	Homo sapiens	114-121
11752045-6	2002	Among recipients of DR-mismatched allografts, a cut-off value of 60 interferon-gamma spots/10(6) cells significantly (P = 0.02) separated stable patients (creatinine concentration, 1.1 +/- 0.3 mg/dl) from high-risk patients (creatinine concentration, 2.3 +/- 1.7 mg/dl).	Creatinine	155-165	interferon gamma	Homo sapiens	68-84
11752045-6	2002	Among recipients of DR-mismatched allografts, a cut-off value of 60 interferon-gamma spots/10(6) cells significantly (P = 0.02) separated stable patients (creatinine concentration, 1.1 +/- 0.3 mg/dl) from high-risk patients (creatinine concentration, 2.3 +/- 1.7 mg/dl).	Creatinine	225-235	interferon gamma	Homo sapiens	68-84
12077495-9	2002	CONCLUSIONS: The fact that serum IGF-1 was correlated with serum transferrin and creatinine clearance suggests that IGF-1 may be a good indicator for assessing the nutritional status of CRF patients.	Creatinine	81-91	insulin like growth factor 1	Homo sapiens	116-121
11921700-5	2002	Urinary NAG excretion levels of IGT group and control group were 2.89 (1.23-7.97) and 2.22 (0.60-4.93) U/g creatinine, median (range), respectively.	Creatinine	107-117	N-acetyl-alpha-glucosaminidase	Homo sapiens	8-11
12227015-6	2002	Although no correlation between urinary calcium/creatinine excretion and urinary vitamins C, B1, B2 and B6 excretion has been found children with increased calcium/creatinine index are insufficiently supplied with four vitamins more often.	Creatinine	164-174	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	93-106
18968460-3	2001	Also, the effect of the albumin concentration in the determination of creatinine has been studied.	Creatinine	70-80	albumin	Homo sapiens	24-31
11728974-7	2001	For HD patients, age and months on HD at enrollment were associated inversely with PTH level, whereas black race, creatinine, and phosphorus were associated directly with PTH.	Creatinine	114-124	parathyroid hormone	Homo sapiens	171-174
11728974-8	2001	For PD patients, age, diabetes, and months on PD at enrollment were inverse predictors, whereas black race, albumin, creatinine, and phosphorus were associated positively with PTH.	Creatinine	117-127	parathyroid hormone	Homo sapiens	176-179
11733364-7	2001	Treatment with rabbit neutralizing antibodies to both KC and MIP-2 inhibited neutrophil infiltration into ischemic kidneys during reperfusion, restored renal function as assessed by decreased serum creatinine and urea nitrogen levels to near normal levels, and resulted in complete survival of treated animals.	Creatinine	198-208	chemokine (C-X-C motif) ligand 2	Mus musculus	61-66
11903396-14	2001	CONCLUSIONS: Intravenous infusion of BNP and ANP both increase the urine excretion of albumin and the tubular protein alpha1 microglobulin, independent of creatinine clearance.	Creatinine	155-165	natriuretic peptide A	Homo sapiens	45-48
12077495-9	2002	CONCLUSIONS: The fact that serum IGF-1 was correlated with serum transferrin and creatinine clearance suggests that IGF-1 may be a good indicator for assessing the nutritional status of CRF patients.	Creatinine	81-91	insulin like growth factor 1	Homo sapiens	33-38
11846868-3	2001	On admission, levels of U-EPX were higher in children with asthma (median: 120 microg/mmol of creatinine; quartiles: 67-123 microg/mmol of creatinine) than in controls (60 microg/mmol of creatinine, 38-74 microg/mmol of creatinine; p&lt; 0.001).	Creatinine	94-104	eosinophil peroxidase	Homo sapiens	26-29
11913598-9	2002	Change in urinary sodium-to-creatinine ratios of 3 consecutive pooled overnight 8-hour urine collections correlated with changes in 24-hour ambulatory SBP (r = 0.294, P&lt;.001) and DBP (r = 0.193, P&lt;.05); however, change in total urinary sodium content was uncorrelated.	Creatinine	28-38	D-box binding PAR bZIP transcription factor	Homo sapiens	182-185
11744455-5	2001	VEGF was measured by enzyme-linked immunosorbent assay in the urine and corrected according to the 24-hour urine concentration of creatinine.	Creatinine	130-140	vascular endothelial growth factor A	Homo sapiens	0-4
11846868-3	2001	On admission, levels of U-EPX were higher in children with asthma (median: 120 microg/mmol of creatinine; quartiles: 67-123 microg/mmol of creatinine) than in controls (60 microg/mmol of creatinine, 38-74 microg/mmol of creatinine; p&lt; 0.001).	Creatinine	139-149	eosinophil peroxidase	Homo sapiens	26-29
11846868-3	2001	On admission, levels of U-EPX were higher in children with asthma (median: 120 microg/mmol of creatinine; quartiles: 67-123 microg/mmol of creatinine) than in controls (60 microg/mmol of creatinine, 38-74 microg/mmol of creatinine; p&lt; 0.001).	Creatinine	139-149	eosinophil peroxidase	Homo sapiens	26-29
11846868-3	2001	On admission, levels of U-EPX were higher in children with asthma (median: 120 microg/mmol of creatinine; quartiles: 67-123 microg/mmol of creatinine) than in controls (60 microg/mmol of creatinine, 38-74 microg/mmol of creatinine; p&lt; 0.001).	Creatinine	139-149	eosinophil peroxidase	Homo sapiens	26-29
11684554-12	2001	AST level was negatively related to serum creatinine level (P = 0.0001).	Creatinine	42-52	solute carrier family 17 member 5	Homo sapiens	0-3
11695972-8	2001	RESULTS: The tumor IL-6 content was the independent factor that influenced the creatinine height index in the elderly patients, whereas Dukes classification was the only independent factor that influenced the creatinine height index in the younger patients.	Creatinine	79-89	interleukin 6	Homo sapiens	19-23
11711499-6	2001	HDL cholesterol was lower and plasma creatinine and urinary albumin/creatinine ratio was higher in the third tertile of fibrinogen.	Creatinine	37-47	fibrinogen beta chain	Homo sapiens	120-130
11711499-6	2001	HDL cholesterol was lower and plasma creatinine and urinary albumin/creatinine ratio was higher in the third tertile of fibrinogen.	Creatinine	68-78	fibrinogen beta chain	Homo sapiens	120-130
11687678-7	2001	After injection of the ACE inhibitor, patients with elevated creatinine levels showed low renal medullary enhancement regardless of the presence of renal artery stenosis (RAS).	Creatinine	61-71	angiotensin I converting enzyme	Homo sapiens	23-26
11687678-8	2001	However, in patients with creatinine less than 2 mg/dL, medullary enhancement ratios after injection of the ACE inhibitor were consistently lower in patients with RAS of 50% or greater than in those without stenosis (P = .02 to .08).	Creatinine	26-36	angiotensin I converting enzyme	Homo sapiens	108-111
11695293-10	2001	The creatinine clearance estimated by the Cockcroft formula was 50 mL.min-1.	Creatinine	4-14	CD59 molecule (CD59 blood group)	Homo sapiens	70-75
11695293-13	2001	Three months after the transplantation, creatinine clearance was 80 mL.min-1.	Creatinine	40-50	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
11677758-7	2001	Analysis of the linear correlation indicated that the level of IL-13 mRNA in the tubulointerstitial area in patients with active LN correlated with the concentration of serum creatinine (Scr), the glomerular activity index (GAI), the activity index of tubulointerstitium, and the level of serum C3 (P &lt; 0.05 for each).	Creatinine	175-185	interleukin 13	Homo sapiens	63-68
11576338-8	2001	Treatment of cystic bpk mice with WTACE2 resulted in a 43% reduction in kidney weight to body weight ratio (11.2 vs. 19.7%), improved cystic index (3.2 vs. 4.8), reduced cystic CT to PT ratio (1.2 vs. 8), and a greater than 30% reduction in BUN and serum creatinine.	Creatinine	255-265	BicC family RNA binding protein 1	Mus musculus	20-23
11698938-11	2001	The creatinine clearance correlated inversely with the peak levels of serum H-FABP (r=-0.75, p=0.0001) and correlated with the peak levels of urinary H-FABP (r=0.64, p=0.003).	Creatinine	4-14	fatty acid binding protein 3	Homo sapiens	76-82
11698938-11	2001	The creatinine clearance correlated inversely with the peak levels of serum H-FABP (r=-0.75, p=0.0001) and correlated with the peak levels of urinary H-FABP (r=0.64, p=0.003).	Creatinine	4-14	fatty acid binding protein 3	Homo sapiens	150-156
11576348-9	2001	Higher serum levels of IgG, anti-dsDNA antibody, lower creatinine clearance, and slight splenomegaly also were found in Nrf2-deficient female mice.	Creatinine	55-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
11561219-6	2001	Taking all patients examined into account, a significant positive relationship emerged between urinary GLP-1 and creatinine clearance (p = 0.004).	Creatinine	113-123	glucagon	Homo sapiens	103-108
11532109-6	2001	The Cox proportional hazards analysis was used to assess the relationship between changes in urine protein excretion during follow-up and the effect of ACE inhibitors on the time to doubling of baseline serum creatinine values or onset of end-stage renal disease.	Creatinine	209-219	angiotensin I converting enzyme	Homo sapiens	152-155
11680000-7	2001	In the follow-up group, creatinine clearance decreased from 27.5 +/- 9.5 mL/min initially, to 19.4 +/- 6.25 mL/min at 3 months, to 13.0 +/- 3.8 mL/min at 6 months (P &lt;.001), while RMR/BW and RMR/BSA increased from 98.28 +/- 6.3, to 101.64 +/- 5.46, to 105.42 +/- 6.3 kJ/kg BW/d (P &lt;.005), respectively, and 4.41 +/- 0.126, to 4.578 +/- 0.168, to 4.704 +/- 0.168 kJ/min/1.73 m(2) (P &lt;.05), respectively.	Creatinine	24-34	CD59 molecule (CD59 blood group)	Homo sapiens	371-376
11544438-4	2001	RESULTS: ACE (D) and AGT (A/A) genotypes were associated with poorer chronic renal transplant function and more rapid chronic progression, defined as an increase of serum creatinine level with time.	Creatinine	171-181	angiotensin I converting enzyme	Homo sapiens	9-12
11562620-7	2001	The median creatinine clearance rose from 67.4 to 96.5 mL/min/1.73 m(2) (P &lt;.05) but remained subnormal in 4 patients.	Creatinine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
11529528-9	2001	When included in a multiple logistic regression analysis, a level of U-EPX &gt; or = 100 microg/mmol creatinine was the only parameter with a positive predictive value for allergic sensitization (p = 0.007, OR = 18.9), whereas age, parental allergy or parental asthma were not.	Creatinine	101-111	eosinophil peroxidase	Homo sapiens	71-74
11529890-14	2001	In a multivariate model with logU-EPX being the dependent variable and adjusted for gender, site and atopy, ozone was found to be significant (estimate: 0.007 microg/mmol creatinine per ppb ozone; SE:0.02; P &lt; 0.001).	Creatinine	171-181	eosinophil peroxidase	Homo sapiens	34-37
11552777-5	2001	The TGF-beta1 concentration was determined by ELISA and normalized to the creatinine concentration.	Creatinine	74-84	transforming growth factor beta 1	Homo sapiens	4-13
11552777-6	2001	RESULTS: The bladder urine TGF-beta1 concentration was significantly (P &lt; 0.02) higher in patients with UPJ obstruction (86.1+/-20.5 pg/mg of creatinine) than in those without obstruction (29.7+/-8.0 pg/mg creatinine).	Creatinine	145-155	transforming growth factor beta 1	Homo sapiens	27-36
11552777-6	2001	RESULTS: The bladder urine TGF-beta1 concentration was significantly (P &lt; 0.02) higher in patients with UPJ obstruction (86.1+/-20.5 pg/mg of creatinine) than in those without obstruction (29.7+/-8.0 pg/mg creatinine).	Creatinine	209-219	transforming growth factor beta 1	Homo sapiens	27-36
11552777-8	2001	The renal pelvic urinary TGF-beta1 concentration was higher in patients for whom endopyelotomy was successful (772+/-490.1 pg/mg of creatinine) than in patients who underwent endopyelotomy and later returned because of UPJ obstruction (126.1+/-41.9 pg/mg of creatinine).	Creatinine	132-142	transforming growth factor beta 1	Homo sapiens	25-34
11552777-8	2001	The renal pelvic urinary TGF-beta1 concentration was higher in patients for whom endopyelotomy was successful (772+/-490.1 pg/mg of creatinine) than in patients who underwent endopyelotomy and later returned because of UPJ obstruction (126.1+/-41.9 pg/mg of creatinine).	Creatinine	258-268	transforming growth factor beta 1	Homo sapiens	25-34
11453706-8	2001	After adjustment for patient and study characteristics at baseline and changes in systolic blood pressure and urinary protein excretion during follow-up, relative risks in the ACE inhibitor group were 0.69 (CI, 0.51 to 0.94) for end-stage renal disease and 0.70 (CI, 0.55 to 0.88) for the combined outcome of doubling of the baseline serum creatinine concentration or end-stage renal disease.	Creatinine	340-350	angiotensin I converting enzyme	Homo sapiens	176-179
11494916-11	2001	CONCLUSION: Patients with renal failure should undergo regular controls of calcium, phosphorus and parathyroid hormone when creatinine clearance is below 50 ml/min/1.73 m2.	Creatinine	124-134	parathyroid hormone	Homo sapiens	99-118
11431175-8	2001	Multivariate analysis using age; sex; duration of diabetes; glycemic, blood pressure, and lipid level control; serum creatinine level; and presence of the ACE D allele showed that presence of the D allele (P = 0.03; odds ratio, 1.8; confidence interval, 1.1 to 3.1) and serum creatinine level (P = 0.0007) were independent risk factors for macroangiopathy.	Creatinine	276-286	angiotensin I converting enzyme	Homo sapiens	155-158
11422745-10	2001	Furthermore, the interstitial expression of C5aR mRNA correlated positively with the level of serum creatinine.	Creatinine	100-110	complement C5a receptor 1	Homo sapiens	44-48
11422769-9	2001	With increasing CRP, creatinine declined significantly [-0.142 mg/dL/month per unit increase in log CRP, adjusted for age, gender, race, diabetes (time since initiation of dialysis; vintage), Kt/V, and nPCR, P = 0.002].	Creatinine	21-31	C-reactive protein	Homo sapiens	16-19
11422769-9	2001	With increasing CRP, creatinine declined significantly [-0.142 mg/dL/month per unit increase in log CRP, adjusted for age, gender, race, diabetes (time since initiation of dialysis; vintage), Kt/V, and nPCR, P = 0.002].	Creatinine	21-31	C-reactive protein	Homo sapiens	100-103
11422769-9	2001	With increasing CRP, creatinine declined significantly [-0.142 mg/dL/month per unit increase in log CRP, adjusted for age, gender, race, diabetes (time since initiation of dialysis; vintage), Kt/V, and nPCR, P = 0.002].	Creatinine	21-31	nasopharyngeal carcinoma-related protein	Homo sapiens	202-206
11422769-10	2001	Serum creatinine increased with increasing nPCR (0.183 mg/dL/month per g/kg/day, P &lt; 0.0001).	Creatinine	6-16	nasopharyngeal carcinoma-related protein	Homo sapiens	43-47
11544438-4	2001	RESULTS: ACE (D) and AGT (A/A) genotypes were associated with poorer chronic renal transplant function and more rapid chronic progression, defined as an increase of serum creatinine level with time.	Creatinine	171-181	angiotensinogen	Homo sapiens	21-24
11590897-12	2001	High CRP group has more increased level of ERI (p &lt; 0.05), age (p &lt; 0.05) and serum creatinine level (p &lt; 0.05) than normal control, but more decreased level of serum albumin (p &lt; 0.01) and serum iron levels (p &lt; 0.05).	Creatinine	90-100	C-reactive protein	Homo sapiens	5-8
11467225-3	2001	In clinical studies serum CRP- und creatinine level declined in healthy subjects and patients with osteoarthritis under rose-hip treatment.	Creatinine	35-45	C-reactive protein	Homo sapiens	26-29
11422818-6	2001	After renal Tx, the ACE II genotype (p = 0.024, chi-square test) and the presence of the I allele (p=0.033, chi-square test) were associated with a favorable slope of 1/creatinine.	Creatinine	169-179	angiotensin I converting enzyme	Homo sapiens	20-23
11375280-8	2001	Assessment of renal function showed a significantly higher plasma creatinine in HO-1(-/-) mice compared with HO-1(+/-) mice.	Creatinine	66-76	heme oxygenase 1	Mus musculus	80-84
11316859-3	2001	The uric acid/creatinine ratio in the urine of uricase-deficient mice ranges from 10 to &gt;30; on a weight basis, these mice excrete 20- to 40-fold more urate than do human subjects.	Creatinine	14-24	urate oxidase	Mus musculus	47-54
11486599-2	2001	Thus, from the relationship among the normalized protein catabolic rate (nPCR) and the intrinsic creatinine generation rate (%GCr) both calculated on the basis of 24-hr urine creatinine, as well as the daily dietary energy intake evaluated by a skilled nutritionist, we devised the following equation to estimate the amount of dietary energy deficiency (delta E) whose supplementation increases the %GCr of patients on protein-restricted dietary regimens to the target level (i.e., the dietary energy deficient amount).	Creatinine	97-107	nuclear receptor subfamily 3 group C member 1	Homo sapiens	126-129
11431902-5	2001	Four months after the administration of an ACE-inhibitor, the urinary protein decreased to 0.04 g while the serum creatinine level increased to 1.5 mg/dl.	Creatinine	114-124	angiotensin I converting enzyme	Homo sapiens	43-46
11340681-7	2001	At baseline, urinary EPX concentrations were higher in children with asthma and those with chronic cough than in controls (mean 171.1 and 131.3, respectively, vs. 60.2 microg/mmol creatinine, P &lt; 0.001).	Creatinine	180-190	eosinophil peroxidase	Homo sapiens	21-24
11304414-9	2001	Serum creatinine level in diabetic patients with insulin treatment was significantly higher than in diabetic patients with sulphonylurea treatment and diet alone.	Creatinine	6-16	insulin	Homo sapiens	49-56
11412630-4	2001	RESULTS: The renal resistive index was significantly higher in the cirrhotic patients with ascites (0.68) than in the compensated cirrhotics (0.63) and was significantly correlated with the serum levels of creatinine,urinary excretion of sodium, plasmatic renin activity and plasmatic concentration of aldosterone.	Creatinine	206-216	renin	Homo sapiens	256-261
11289481-8	2001	For the 59 patients with diabetes with creatinine clearance &gt;60 ml/min, insulin sensitivity indexes were also shown to be a significant contributor to log tHcy (beta = -0.438, R2 = 0.561, P &lt; 0.001).	Creatinine	39-49	insulin	Homo sapiens	75-82
11336184-7	2001	Persistent Mi (Alb+) was defined as an average albumin-to-creatinine ratio between 2.38 and 19 (men) and 2.96 and 20 (women).	Creatinine	58-68	albumin	Homo sapiens	15-18
11274243-4	2001	Patients with an elevated CRP (&gt;6 mg/L; n = 29) had significantly reduced plasma prealbumin (0.36 +/- 0.02 versus 0.44 +/- 0.03 g/L; P: &lt; 0.05), decreased total weekly creatinine clearance (C(Cr); 52.5 +/- 2.3 versus 63.1 +/- 3.2 L/1.73 m(2); P: &lt; 0.01), and increased left ventricular thickness (1.24 +/- 0.05 versus 1.08 +/- 0.06 cm; P: &lt; 0.05) at baseline compared with those who had a normal CRP (&lt; or =6 mg/L; n = 21).	Creatinine	174-184	C-reactive protein	Homo sapiens	26-29
11287775-8	2001	Plasma L-PGDS was determined by plasma creatinine (Cr) concentration while urinary L-PGDS excretion was correlated solely with urinary protein excretion.	Creatinine	39-49	prostaglandin D2 synthase	Homo sapiens	7-13
11287775-10	2001	The averaged plasma concentration of L-PGDS in the diabetics with a normal Cr level in plasma, corresponding to that in the controls, was determined by the plasma Cr concentration.	Creatinine	75-77	prostaglandin D2 synthase	Homo sapiens	37-43
11287775-10	2001	The averaged plasma concentration of L-PGDS in the diabetics with a normal Cr level in plasma, corresponding to that in the controls, was determined by the plasma Cr concentration.	Creatinine	163-165	prostaglandin D2 synthase	Homo sapiens	37-43
11287775-11	2001	On the other hand, the urinary L-PGDS excretion was determined by the amount of proteinuria and greater in the diabetics with a normal Cr level in plasma than in the controls even when the patients exhibited urinary protein excretion equal to that in the control subjects.	Creatinine	135-137	prostaglandin D2 synthase	Homo sapiens	31-37
11292301-13	2001	When the analysis was controlled for the presence of delayed graft function, 40.5% of the high IFN-gamma genotype patients had serum creatinine levels above 200 micromol/L compared with only 14.3% of the low IFN-gamma genotype recipients at 5 years after transplantation (P=0.05).	Creatinine	133-143	interferon gamma	Homo sapiens	95-104
11325074-6	2001	Systolic and diastolic blood pressure were significantly reduced from 150/90 +/- 15/11 mmHg to 130/75 +/- 11/9 mmHg (ACE) and the levels of serum creatinine were increased significantly from 1.8 +/- 0.3 to 2.0 +/- 0.4 mg/dl (ACE).	Creatinine	146-156	angiotensin I converting enzyme	Homo sapiens	225-228
11314805-9	2001	CONCLUSIONS: Our data confirm the receptorial defect of glycoprotein GPIb (the receptor for vWF) on the surface of uremic platelets: a negative correlation between serum creatinine and the expression of glycoprotein GPIb was found.	Creatinine	170-180	von Willebrand factor	Homo sapiens	92-95
11176522-6	2001	RESULTS: Preoperatively serum tumor associated trypsin inhibitor was elevated with a cutoff 16 microg/l in 48% of the patients with normal serum creatinine.	Creatinine	145-155	serine peptidase inhibitor Kazal type 1	Homo sapiens	30-64
11287759-10	2001	The intensity of interstitial TGF-beta(1) protein expression was significantly related to the degree of interstitial fibrosis (r = 0.628, p &lt; 0.01), tubular atrophy (r = 0.612, p &lt; 0.01), interstitial collagen III expression (r = 0.478, p &lt; 0.05), and serum creatinine values (r = 0.722, p &lt; 0.001).	Creatinine	267-277	transforming growth factor beta 1	Homo sapiens	30-41
11355603-4	2001	The most widely accepted criterion is a level of creatinine clearance estimated by the Cockcroft-Gault formula between 7 and 10 mL/min/1.73 m2.	Creatinine	49-59	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
11403100-6	2001	A significant negative correlation was obtained between serum creatinine and plasma renin activity (r=-0.842, p&lt;0.001) in macroalbuminuric NIDDM patients.	Creatinine	62-72	renin	Homo sapiens	84-89
11350271-8	2001	In pre-dialysis patients, serum creatinine ranged from 110 to 447 microM L-1 and was significantly correlated to plasma N-terminal proANP (r = 0.60, P &lt; 0.05) but not to ANP.	Creatinine	32-42	natriuretic peptide A	Homo sapiens	134-137
11164664-0	2001	The effect of growth hormone on 24-h urinary creatinine levels in burned patients.	Creatinine	45-55	growth hormone 1	Homo sapiens	14-28
11164664-4	2001	We investigated the effect of GH on 24-h urinary creatinine levels as an indicator of catabolism of muscle mass in burned patients.	Creatinine	49-59	growth hormone 1	Homo sapiens	30-32
11164664-16	2001	We concluded that GH is effective in decreasing urinary creatinine excretion.	Creatinine	56-66	growth hormone 1	Homo sapiens	18-20
11269680-7	2001	The elevated total serum concentrations of apo AIV were mainly related to creatinine clearance and partially to serum triglyceride levels in renal transplant recipients.	Creatinine	74-84	apolipoprotein A4	Homo sapiens	43-50
11403100-13	2001	Thus plasma renin activity is decreased in diabetic nephropathy and negatively correlates with serum creatinine.	Creatinine	101-111	renin	Homo sapiens	12-17
11168932-12	2001	Treatment with alpha-TGF-beta in CsA-treated rats significantly prevented the reduction in creatinine clearance (0.58 +/- 0.03 mL/min, P = 0.009 vs. CsA alone), the increase in afferent arteriolar hyalinosis (P &lt; 0.05 vs. CsA alone), normalized alpha 1(I) collagen mRNA levels, and attenuated CsA effects on TGF-beta1, TIMP-1, and MMP-9.	Creatinine	91-101	transforming growth factor, beta 1	Rattus norvegicus	21-29
11174469-2	2001	Locally produced VEGF (LVEGF) was positively related to the mass transfer area coefficient (MTAC) of creatinine and to glucose absorption, both of which are representative of the peritoneal vascular surface area.	Creatinine	101-111	vascular endothelial growth factor A	Homo sapiens	17-21
11122254-4	2000	Heterozygous TAP-1 mice have normal MHC I expression and developed GN with crescents in 42 +/- 4% of glomeruli (normal 0%), proteinuria (9.1 +/- 1.6 mg/20 h, normal 1.5 +/- 0.3 mg/20 h) and impaired renal function (creatinine clearance 110 +/- 8 microl/min, normal 193 +/- 10 microl/min) following administration of sheep anti-mouse GBM globulin.	Creatinine	215-225	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	13-18
11345609-13	2001	CONCLUSIONS: Vitamin B12 deficiency, defined as an increase in the MMA/creatinine ratio and TH normalized with B12, is highly prevalent among elderly subjects and may occur in absence of clinical and/or analytical manifestations.	Creatinine	71-81	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	21-24
11510266-1	2001	The aim of the present study was to examine the association between 4-hour dialysate-to-plasma ratio of creatinine (D/PCr), erythropoietin (EPO) responsiveness [EPO (U/week)/hemoglobin (g/L)], and C-reactive protein (CRP).	Creatinine	104-114	erythropoietin	Homo sapiens	124-138
11510266-1	2001	The aim of the present study was to examine the association between 4-hour dialysate-to-plasma ratio of creatinine (D/PCr), erythropoietin (EPO) responsiveness [EPO (U/week)/hemoglobin (g/L)], and C-reactive protein (CRP).	Creatinine	104-114	erythropoietin	Homo sapiens	161-164
11446565-9	2001	Moreover, PTH correlated with creatinine and osteocalcin values.	Creatinine	30-40	parathyroid hormone	Homo sapiens	10-13
11097747-6	2000	The incidence of acute rejection episodes, vascular damage (grade III degrees of Banff classification), and serum creatinine levels at 1 month, were significantly greater in high TNF-alpha producers (P=0.	Creatinine	114-124	tumor necrosis factor	Homo sapiens	179-188
11134124-16	2000	IGF-I was positively associated with creatinine clearance, serum calcium, and phosphate and negatively associated with PTH (P: &lt; 0.001).	Creatinine	37-47	insulin like growth factor 1	Homo sapiens	0-5
10999979-9	2000	In stratified models, the receipt of an ACE inhibitor was associated with a 37% (16%-52%) lower mortality for patients who had poor renal function (serum creatinine level,&lt;265 micromol/L [&lt;3 mg/dL]) and a 16% (8%-23%) lower mortality for patients who had better renal function.	Creatinine	154-164	angiotensin I converting enzyme	Homo sapiens	40-43
11054346-9	2000	Alb/Cr was independently associated with increased HbA(1c) level (P = 0.0070), MAP (P = 0.0001), BMI (P = 0.0156), log-transformed triglyceride levels (P = 0.0031), C-peptide level of 6.5 ng/mL or greater (P = 0.0007), serum creatinine level (P: = 0.0068), and male sex (P = 0.0220).	Creatinine	225-235	albumin	Homo sapiens	0-3
11046208-11	2000	Plasma TNFalpha at 2 h correlated with urinary NAG/creatinine ratio at 2 and 6 h (P &lt; 0.05) and with urinary IL-1ra at 2 h (P &lt; 0.05).	Creatinine	51-61	tumor necrosis factor	Homo sapiens	7-15
11046208-12	2000	Plasma IL-8 at 2 h correlated with NAG/creatinine at 6 h (P &lt; 0.05).	Creatinine	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
11081765-5	2000	Advanced age, higher initial serum creatinine, history of hypertension, diabetes and atrial fibrillation predict the onset of GFR impairment associated with blockade of the renin-angiotensin system.	Creatinine	35-45	renin	Homo sapiens	173-178
11687440-9	2001	Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	58-68	interleukin 1 beta	Homo sapiens	97-106
11687440-9	2001	Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	58-68	interleukin 6	Homo sapiens	108-112
11687440-9	2001	Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	58-68	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
11687440-10	2001	Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	56-66	interleukin 1 beta	Homo sapiens	100-109
11687440-10	2001	Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	56-66	interleukin 6	Homo sapiens	111-115
11687440-10	2001	Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
11063957-7	2000	Creatinine clearance was significantly and inversely correlated with levels of plasma fibrinogen (Spearman"s rho = -0.26, P &lt;0.001), D-dimer (rho = -0.33, P &lt;0.001), and prothrombin fragment 1 + 2 (rho = -0.20, P &lt;0.001).	Creatinine	0-10	fibrinogen beta chain	Homo sapiens	86-96
11063957-10	2000	CONCLUSIONS: Increased plasma levels of fibrinogen, D-dimer, and prothrombin fragment 1 + 2 are present in hypertensive patients with mildly decreased creatinine clearance, suggesting that the coagulation system is activated in these patients.	Creatinine	151-161	fibrinogen beta chain	Homo sapiens	40-50
11193277-18	2000	CONCLUSION: During norepinephrine infusion, increasing doses of dopamine from 2 to 6 microg x kg(-1) x min(-1) augments CO, diuresis and sodium excretion in patients treated for septic shock, without changes in creatinine clearance.	Creatinine	211-221	CD59 molecule (CD59 blood group)	Homo sapiens	103-109
11030379-3	2000	RESULTS: U-EPX was increased in children with AD (110; 67-164 microg/mmol creatinine, median; quartiles) compared to controls (62; 41-95, P&lt;0.001).	Creatinine	74-84	eosinophil peroxidase	Homo sapiens	11-14
11106196-7	2000	Urinary EPX was also significantly increased in asthmatic children compared with controls (85.5 [64-131.5] SD 76.2 versus 48.5 [43.2-90] 112.1 microg x mmol(-1) creatinine; p=0.006).	Creatinine	161-171	eosinophil peroxidase	Homo sapiens	8-11
10999979-12	2000	Use of aspirin therapy may attenuate the benefit of ACE inhibitors in patients with high serum creatinine levels; therefore, further studies are needed to determine whether treatment with aspirin, alternative antiplatelet agents, or anticoagulation is indicated for these patients.	Creatinine	95-105	angiotensin I converting enzyme	Homo sapiens	52-55
10966936-6	2000	Liver L-tryptophan 2,3-dioxygenase activity (TDO), a rate-limiting enzyme of the kynurenine pathway, was increased in proportion to blood urea nitrogen and creatinine levels.	Creatinine	156-166	tryptophan 2,3-dioxygenase	Rattus norvegicus	45-48
11103842-5	2000	The activity of N-acetyl-beta-D-glucosaminidase in urine (U-NAG) was higher in the exposed workers (mean 0.18 U/mmol Cr versus 0.14 U/mmol Cr, P=0.02).	Creatinine	117-119	N-acetyl-alpha-glucosaminidase	Homo sapiens	60-63
10980121-4	2000	In addition, a significant negative correlation between galectin-3 mRNA expression and serum reciprocal creatinine was shown at 48 hours after injury (n = 13, r = -0.94, P: &lt; 0.0001).	Creatinine	104-114	galectin 3	Rattus norvegicus	56-66
10873662-4	2000	Repeated intravenous injection of human insulin vector every week resulted in a sustained decrease in serum glucose over a 4-week period, accompanied by the detection of C-peptide fragments and a significant decrease in BUN and creatinine.	Creatinine	228-238	insulin	Homo sapiens	40-47
11714010-8	2000	However, there was a statistically significant difference in the mean creatinine clearance of the control group 102 ml/min/1.73 m2 when compared with the patient"s mean pre-treatment value (89 ml/min/1.73 m2) P &lt; 0.05.	Creatinine	70-80	CD59 molecule (CD59 blood group)	Homo sapiens	119-124
11714010-9	2000	Also the mean creatinine clearance increased to (103 ml/min/1.73 m2) by the end of the 6th month of treatment, a value that is statistically significant when compared with the pretreatment value of (89 ml/min/1.73 m2) P &lt; 0.05.	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
11714010-9	2000	Also the mean creatinine clearance increased to (103 ml/min/1.73 m2) by the end of the 6th month of treatment, a value that is statistically significant when compared with the pretreatment value of (89 ml/min/1.73 m2) P &lt; 0.05.	Creatinine	14-24	CD59 molecule (CD59 blood group)	Homo sapiens	205-210
10972692-6	2000	RESULTS: Adjusted creatinine clearance was higher in current smokers than in former smokers and never smokers (100.6 +/- 13.6 vs. 98.8 +/- 13.9 mL/min/1.73 m2, P &lt; 0.0001, and vs. 98.5 +/- 14.0 mL/min/1.	Creatinine	18-28	CD59 molecule (CD59 blood group)	Homo sapiens	147-152
10972692-6	2000	RESULTS: Adjusted creatinine clearance was higher in current smokers than in former smokers and never smokers (100.6 +/- 13.6 vs. 98.8 +/- 13.9 mL/min/1.73 m2, P &lt; 0.0001, and vs. 98.5 +/- 14.0 mL/min/1.	Creatinine	18-28	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
10972692-10	2000	Creatinine clearance was associated with a relative risk of proteinuria [for each mL/min/1.73 m2, the relative risk was 1.007 (95% CI, 1.000 to 1.015), P = 0.056, for 1+ or higher proteinuria; and 1.018 (1.004 to 1.030), P = 0.0078, for 2+ or higher proteinuria].	Creatinine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	85-90
10997699-7	2000	A weak but significant correlation was found between urinary VEGF excretion and the levels of serum creatinine, creatinine clearance, microalbuminuria, and proteinuria.	Creatinine	100-110	vascular endothelial growth factor A	Homo sapiens	61-65
10997699-7	2000	A weak but significant correlation was found between urinary VEGF excretion and the levels of serum creatinine, creatinine clearance, microalbuminuria, and proteinuria.	Creatinine	112-122	vascular endothelial growth factor A	Homo sapiens	61-65
10910477-0	2000	Preliminary report on the association of apolipoprotein E polymorphisms, with postoperative peak serum creatinine concentrations in cardiac surgical patients.	Creatinine	103-113	apolipoprotein E	Homo sapiens	41-57
10910477-3	2000	The authors therefore tested the hypothesis that apolipoprotein E alleles are associated with different postoperative changes in serum creatinine after cardiac surgery.	Creatinine	135-145	apolipoprotein E	Homo sapiens	49-65
10910477-5	2000	Renal function was assessed among apolipoprotein E genotype groups by comparisons of preoperative (CrPre), peak in-hospital postoperative (CrMax) and perioperative change (DCr) in serum creatinine values.	Creatinine	186-196	apolipoprotein E	Homo sapiens	34-50
10910477-8	2000	CONCLUSIONS: Inheritance of the apolipoprotein epsilon4 allele is associated with reduced postoperative increase in serum creatinine after cardiac surgery, compared with the epsilon3 or epsilon2 allele.	Creatinine	122-132	apolipoprotein E	Homo sapiens	32-46
10930966-8	2000	RESULTS: An increase in Epo levels occurred following every course of 5-FU or platinum based chemotherapy in patients with steady concentrations of creatinine and decreased levels of haemoglobin (Hb).	Creatinine	148-158	erythropoietin	Homo sapiens	24-27
10921586-15	2000	E-selectin deficient mice showed lower creatinine and blood urea nitrogen concentrations than wild-type mice at 24 and 48 hrs (a reduction of 60% to 80%).	Creatinine	39-49	selectin, endothelial cell	Mus musculus	0-10
10921586-19	2000	Compared with control antibody, postischemic injection of anti-E-selectin antibody gave lower creatinine concentrations at 24 hrs, similar to that seen in E-selectin deficient mice.	Creatinine	94-104	selectin, endothelial cell	Mus musculus	63-73
10875254-8	2000	The greater increase in circulating levels of IL-6 in PTH-treated ovx mice was paralleled by a greater rise in bone resorption markers with the mean level of urine collagen cross-links in the PTH-treated ovx group being more than 2.5-fold higher than in the PTH-treated sham/ovx animals (236 vs. 88.5 microg/mmol creatinine, P &lt; 0.0001).	Creatinine	313-323	interleukin 6	Mus musculus	46-50
10886559-12	2000	Such oxidative stress was functionally significant, since the administration of angiotensin II to rats maintained on a prooxidant diet demonstrated increased proteinuria and decreased creatinine clearance.	Creatinine	184-194	angiotensinogen	Rattus norvegicus	80-94
10844604-8	2000	RESULTS: In healthy control subjects, urinary VEGF excretion was 68 +/- 10 (95% CI, 49 to 88) ng/mmol creatinine (UCr).	Creatinine	102-112	vascular endothelial growth factor A	Homo sapiens	46-50
10925100-8	2000	RESULTS: Urinary TGF-beta(1) excretion was significantly greater in patients with PUV (range 0 to 0.063, median 0.019 ng/mg urine creatinine) compared with that of healthy controls (range 0 to 0.022, median 0.005 ng/mg urine creatinine) (P &lt;0.01).	Creatinine	130-140	transforming growth factor beta 1	Homo sapiens	17-28
10925100-8	2000	RESULTS: Urinary TGF-beta(1) excretion was significantly greater in patients with PUV (range 0 to 0.063, median 0.019 ng/mg urine creatinine) compared with that of healthy controls (range 0 to 0.022, median 0.005 ng/mg urine creatinine) (P &lt;0.01).	Creatinine	225-235	transforming growth factor beta 1	Homo sapiens	17-28
10788454-6	2000	Levels of PGE(2) in the urine of iNOS-deficient mice were decreased 78% (0.24 +/- 0.14 ng/mg of creatinine versus 1.09 +/- 0.66 ng/mg of creatinine, p &lt; 0.01) compared with control animals.	Creatinine	96-106	nitric oxide synthase 2, inducible	Mus musculus	33-37
10788454-6	2000	Levels of PGE(2) in the urine of iNOS-deficient mice were decreased 78% (0.24 +/- 0.14 ng/mg of creatinine versus 1.09 +/- 0.66 ng/mg of creatinine, p &lt; 0.01) compared with control animals.	Creatinine	137-147	nitric oxide synthase 2, inducible	Mus musculus	33-37
10878408-9	2000	The TGF-beta(1)-stained interstitial area showed positive correlations with the interstitial fibrosis area, the number of TIMP-1-positive cells, and the number of macrophages, and showed a negative correlation with creatinine clearance.	Creatinine	215-225	transforming growth factor, beta 1	Rattus norvegicus	4-15
10779410-7	2000	The levels of uMCP were correlated significantly with those of serum MCP (sMCP) and N-acetyl-beta-glucosaminidase and nonsignificantly with those of beta(2)-microglobulin, total urine protein, or serum creatinine.	Creatinine	202-212	CD46 molecule	Homo sapiens	15-18
10810088-4	2000	Bovine CINF, characterized by increased blood urea nitrogen, creatinine, and urinary proteins, leads to lethality before puberty, usually within the first 6 months or year of life.	Creatinine	61-71	CINF	Bos taurus	7-11
10838668-12	2000	The influence of renal toxicity was further assessed by comparing the median creatinine value at the time IL-2 dosing was discontinued.	Creatinine	77-87	interleukin 2	Homo sapiens	106-110
10838668-17	2000	The decreasing tolerance to IL-2 was associated primarily with elevations in creatinine.	Creatinine	77-87	interleukin 2	Homo sapiens	28-32
10773753-4	2000	The respective urine and plasma concentrations of hBD-1 in patients with pyelonephritis are 48.1 +/- (SEM) 15.7 pmol/mg creatinine and 2.66 +/- 0.41 pmol/ml, 3.1-fold and 1.8-fold those of normal individuals.	Creatinine	120-130	defensin beta 1	Homo sapiens	50-55
10739792-6	2000	In seven trials of subjects with overt proteinuria and renal insufficiency from a variety of causes (30% diabetes, 70% nondiabetes), the relative risk for doubling of serum creatinine concentration or developing end-stage renal disease was 0.60 (95% CI, 0.49 to 0.73) for individuals treated with an ACE inhibitor compared with placebo.	Creatinine	173-183	angiotensin I converting enzyme	Homo sapiens	300-303
10712391-3	2000	Using maximum-likelihood-based variance decomposition methods, we determined that sex, age, and plasma levels of HDL cholesterol, apoA-I, and creatinine accounted for 38.6% of the variance in plasma EC-SOD levels and that additive genes accounted for 35% (P&lt;0.00002).	Creatinine	142-152	superoxide dismutase 3	Homo sapiens	199-205
10718776-6	2000	Decreases in predicted renal clearance and volume of distribution of 82 and 69%, respectively, were observed when creatinine clearance decreased from 120 to 20 ml min-1.	Creatinine	114-124	CD59 molecule (CD59 blood group)	Homo sapiens	163-168
10724055-0	2000	Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: is this a cause for concern?	Creatinine	71-81	angiotensin I converting enzyme	Homo sapiens	0-29
10729656-7	2000	CART analysis revealed that isolation of Enterococcus faecium, prior vancomycin exposure, and serum creatinine values &gt; or = 1.1 mg/dl were predictors of VRE bacteremia.	Creatinine	100-110	CART prepropeptide	Homo sapiens	0-4
10720598-3	2000	Ang II infusion decreased the glomerular filtration rate (GFR) as determined through creatinine clearance (3.2+/-0.2 versus 1.2+/-0.2 mL/min with Ang II infusion, P&lt;0.01) and increased proteinuria (9.	Creatinine	85-95	angiotensinogen	Rattus norvegicus	0-6
10726914-5	2000	Active TGF-beta1 concentrations were correlated with urinary albumin excretion (r = .49, P &lt; .003) and serum creatinine (r= .55, P &lt; .01).	Creatinine	112-122	transforming growth factor beta 1	Homo sapiens	7-16
10686284-1	2000	Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.	Creatinine	104-114	erythropoietin	Homo sapiens	47-61
10718776-7	2000	A 64% decrease in predicted oral clearance was observed when creatinine clearance decreased from 120 to 20 ml min-1 (P=0.064).	Creatinine	61-71	CD59 molecule (CD59 blood group)	Homo sapiens	110-115
10652036-10	2000	Renal function was shown by the 24-hour UAE, creatinine clearance (CCr), and the regression coefficient of the yearly plasma creatinine reciprocal (beta-1/Cr).	Creatinine	125-135	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	148-157
10653381-11	2000	It is interesting that the efficacy of steroid therapy in the patients with elevated creatinine could be predicted by CD15s expression on the peripheral lymphocytes before graft biopsy.	Creatinine	85-95	fucosyltransferase 4	Homo sapiens	118-122
10653381-13	2000	We report that the detection of CD15s on the peripheral lymphocytes by flow cytometry was an easy, helpful, and noninvasive means for the diagnosis and treatment of patients with elevated creatinine after renal transplantation.	Creatinine	188-198	fucosyltransferase 4	Homo sapiens	32-36
10961356-2	2000	Therefore, the aim of our study was to investigate leptin and TNF alpha levels and their association with blood pressure, sex steroids, insulin, creatinine and lipids in type 2 diabetic patients.	Creatinine	145-155	tumor necrosis factor	Homo sapiens	62-71
10657833-6	2000	The mean creatinine clearance increased from 90 +/- 23 to 107 +/- 23 mL/min/1.73 mol/L(2) (P &lt;.01), and the mean 24-hour urine protein excretion decreased from 2.0 +/- 2.4 g/24 h to 0.5 +/- 0.7 g/24 h (P &lt;.05).	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
11229627-5	2000	Our study suggests that the addition of verapamil to ACE inhibitors can reverse ACE-induced increase in creatinine levels in elderly hypertensive patients in whom this side effect is observed.	Creatinine	104-114	angiotensin I converting enzyme	Homo sapiens	53-56
11229627-5	2000	Our study suggests that the addition of verapamil to ACE inhibitors can reverse ACE-induced increase in creatinine levels in elderly hypertensive patients in whom this side effect is observed.	Creatinine	104-114	angiotensin I converting enzyme	Homo sapiens	80-83
10961356-10	2000	In females TNF alpha was positively correlated with creatinine (p&lt;0.001) and in males positively with progesterone (p&lt;0.001).	Creatinine	52-62	tumor necrosis factor	Homo sapiens	11-20
10955598-6	2000	By ROC curve analysis, the optimal cutoff values for EGFR-binding growth factors were 25.5 microg/g creatinine (radioreceptor assay) and 33.6 microg/g creatinine (radioimmunoassay).	Creatinine	100-110	epidermal growth factor receptor	Homo sapiens	53-57
10728802-15	2000	The long-term administration (1-3 weeks) of analogs of vasopressin (ornipressin or terlipressin) or other vasoconstrictors together with plasma volume expansion with albumin is associated with a dramatic improvement in circulatory function and normalization of serum creatinine concentration in patients with severe hepatorenal syndrome.	Creatinine	267-277	arginine vasopressin	Homo sapiens	55-66
10955598-6	2000	By ROC curve analysis, the optimal cutoff values for EGFR-binding growth factors were 25.5 microg/g creatinine (radioreceptor assay) and 33.6 microg/g creatinine (radioimmunoassay).	Creatinine	151-161	epidermal growth factor receptor	Homo sapiens	53-57
11117106-3	2000	They are dominated by hyperparathyroidism which will be diagnosed on the initially yearly determination of plasma intact PTH as soon as creatinine clearance decreases below 60 ml/min, eventhough there is still no modification in plasma concentrations of calcium and phosphate.	Creatinine	136-146	parathyroid hormone	Homo sapiens	121-124
10619572-3	1999	The ability of ACE inhibitors to stabilize renal function is not attenuated by more severe renal insufficiency, but greater caution with these drugs is necessary, as there may be drug accumulation and a greater propensity for an increase in serum potassium and creatinine levels.	Creatinine	261-271	angiotensin I converting enzyme	Homo sapiens	15-18
11052272-7	2000	Regression analysis revealed a weak correlation between serum creatinine and ET-1 (r = 0.192, P = 0.04) and a significant correlation between serum bilirubin and ET-1 (r = 0.395, P &lt; 0.001).	Creatinine	62-72	endothelin 1	Homo sapiens	77-81
11529189-4	1999	The mean observed urinary nickel concentration was 12 micrograms L-1 (11 micrograms of Ni per g of creatinine).	Creatinine	99-109	immunoglobulin kappa variable 1-16	Homo sapiens	65-68
10632337-10	1999	A multivariate logistic regression analysis including age, WBC count, percentage of peripheral and marrow blasts, hemoglobin, albumin, lactate dehydrogenase, bilirubin, and creatinine determined that a high level of caspase 3 was the most significant predictor of CR (P = 0.025, adjusted), with albumin the only other significant variable (P = 0.031).	Creatinine	173-183	caspase 3	Homo sapiens	216-225
10539812-6	1999	Family physicians expressed more concern over the risks of ACE inhibitors in patients with blood pressure of 100/70 mm Hg or serum creatinine of 2.0 mg/dL and were less likely to prescribe an ACE inhibitor in these settings.	Creatinine	131-141	angiotensin I converting enzyme	Homo sapiens	59-62
10520077-4	1999	METHODS: Urinary EPX excretion (microg/mmol creatinine) was measured in the morning and afternoon in 22 stable asthmatics and in 16 nonatopic, nonasthmatic controls to investigate circadian variation.	Creatinine	44-54	eosinophil peroxidase	Homo sapiens	17-20
10639701-10	1999	Increased urinary excretion of the fibrogenic cytokine transforming growth factor (TGF-beta 1) was improved, too (CTRL-PL 0.349 +/- 0.051, CTRL-E 0.693 +/- 0.230, 5/6 NX-PL 3.044 +/- 0.540, 5/6 NX-E 1.390 +/- 0.238 ng/mumol creatinine; P &lt; 0.05).	Creatinine	224-234	transforming growth factor, beta 1	Rattus norvegicus	83-93
10527701-6	1999	RESULTS: After 45 and 60 min of ischemia, serum creatinine and BUN were significantly higher in the control than in animals treated with anti-CD11a and anti-CD18 at 24 and 48 h. Administration of anti-CD11b had a beneficial effect on renal function after 45 min but not after 60 min of ischemia.	Creatinine	48-58	integrin subunit alpha M	Rattus norvegicus	201-206
10951856-0	1999	[Effect of ACE-inhibitors on changes in creatinine in the blood-- introduction].	Creatinine	40-50	angiotensin I converting enzyme	Homo sapiens	11-14
10520077-6	1999	RESULTS: EPX excretion in the first morning urine sample of the day compared with the afternoon urine sample was significantly higher both in children with asthma (n = 22; mean +/- standard deviation: 179.7 +/- 97.3 vs 60.9 +/- 40.7 microg/mmol creatinine, P = 0.0001) and in nonatopic nonasthmatic controls (n = 16; 114.5 +/- 57.1 vs 53.4 +/- 29.0 microg/mmol creatinine, P = 0.0001).	Creatinine	245-255	eosinophil peroxidase	Homo sapiens	9-12
10520077-6	1999	RESULTS: EPX excretion in the first morning urine sample of the day compared with the afternoon urine sample was significantly higher both in children with asthma (n = 22; mean +/- standard deviation: 179.7 +/- 97.3 vs 60.9 +/- 40.7 microg/mmol creatinine, P = 0.0001) and in nonatopic nonasthmatic controls (n = 16; 114.5 +/- 57.1 vs 53.4 +/- 29.0 microg/mmol creatinine, P = 0.0001).	Creatinine	361-371	eosinophil peroxidase	Homo sapiens	9-12
10354294-8	1999	In multiple regression analysis, the correlation between the sum of insulin levels and the reciprocal of serum creatinine remained significant even after controlling for age, sex, body mass index, blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, alcohol intake, and smoking habits.	Creatinine	111-121	insulin	Homo sapiens	68-75
10443671-9	1999	There was also a significant increase in the urinary measure of type I collagen degradation of aminoterminal telopeptides from 78+/-45 to 101+/-51 nmol/mmol creatinine (P &lt; 0.05) when hPTH-(1-34) was infused, but it was not affected (68+/-30 vs. 66+/-24 nmol/mmol creatinine) by hPTH-(1-31).	Creatinine	267-277	parathyroid hormone	Homo sapiens	187-191
10412773-6	1999	RESULTS: Plasma creatinine at 1.5 +/- 0.1 mg/dl was lower in the AST group than the 1.9 +/- 0.5 mg/ml level in the control group.	Creatinine	16-26	solute carrier family 17 member 5	Homo sapiens	65-68
10404693-5	1999	IgA nephropathy patients with tubulointerstitial damage also showed an increased serum creatinine level compared to patients without the damage (p &lt; 0.03).	Creatinine	87-97	CD79a molecule	Homo sapiens	0-3
10411356-1	1999	A 35-year-old man with immunoglobulin A (IgA) nephropathy who developed hemolytic uremic syndrome (HUS) presented with transient elevation of serum creatinine, thrombocytopenia, and hemolytic anemia with fragmented red cells with nephrotic syndrome.	Creatinine	148-158	CD79a molecule	Homo sapiens	23-39
10411356-1	1999	A 35-year-old man with immunoglobulin A (IgA) nephropathy who developed hemolytic uremic syndrome (HUS) presented with transient elevation of serum creatinine, thrombocytopenia, and hemolytic anemia with fragmented red cells with nephrotic syndrome.	Creatinine	148-158	CD79a molecule	Homo sapiens	41-44
10354294-5	1999	RESULTS: The correlation analysis showed that serum insulin, blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglycerides, and body mass index were all negatively correlated with the reciprocal of serum creatinine level (P &lt; 0.01), and alcohol intake was positively correlated (P &lt; 0.05) in both sexes.	Creatinine	228-238	insulin	Homo sapiens	52-59
10354294-7	1999	When the subjects were divided into quartiles based on the sum of fasting and two-hour postloading insulin levels, the averages of the reciprocal of serum creatinine were significantly lower in the fourth quartile (0.90 +/- 0.10 for men and 1.10 +/- 0.14 for women) compared with the lowest quartile (0.95 +/- 0.12 and 1.13 +/- 0.13, respectively) in both sexes (P &lt; 0.05).	Creatinine	155-165	insulin	Homo sapiens	99-106
11057851-7	2000	Elevated D-dimer and fibrinogen levels were independently associated with the presence of decreased creatinine clearance.	Creatinine	100-110	fibrinogen beta chain	Homo sapiens	21-31
11057851-8	2000	Log fibrinogen, log F1+2, and log D-dimer were inversely correlated with creatinine clearance.	Creatinine	73-83	fibrinogen beta chain	Homo sapiens	4-14
10484522-4	1999	iNOS knockout mice demonstrated an attenuation of serum creatinine concentration after renal I/R injury.	Creatinine	56-66	nitric oxide synthase 2, inducible	Mus musculus	0-4
10484522-5	1999	Serum creatinine concentrations (mg/dl) after a 24-h reperfusion were 2.3 +/- 0.22 in wild-type ischemic and 1.21 +/- 0.25 in iNOS knockout ischemic mice (P &lt; 0.05); after 48 h, concentrations were 2.0 +/- 0.18 in wild-type ischemic and 0.96 +/- 0.25 in iNOS knockout ischemic mice (P &lt; 0.01).	Creatinine	6-16	nitric oxide synthase 2, inducible	Mus musculus	126-130
10430982-12	1999	These animals also presented a greater rate of urinary TGF-beta excretion reported as picograms of TGF-beta per milligram of urinary creatinine (P &lt; 0.05), which was 202 +/- 11 pg/mg in group C, 1, 103 +/- 580 pg/mg in group AD, and 299 +/- 128 pg/mg in group AD-B.	Creatinine	133-143	transforming growth factor, beta 1	Rattus norvegicus	55-63
10430982-12	1999	These animals also presented a greater rate of urinary TGF-beta excretion reported as picograms of TGF-beta per milligram of urinary creatinine (P &lt; 0.05), which was 202 +/- 11 pg/mg in group C, 1, 103 +/- 580 pg/mg in group AD, and 299 +/- 128 pg/mg in group AD-B.	Creatinine	133-143	transforming growth factor, beta 1	Rattus norvegicus	99-107
10480223-9	1999	Plasma mAM levels were significantly correlated positively with serum creatinine levels and negatively with hematocrit.	Creatinine	70-80	activating transcription factor 7 interacting protein	Mus musculus	7-10
10462266-9	1999	In addition, increased urinary ir-ET-1 excretion correlated with the rise in serum creatinine and proteinuria.	Creatinine	83-93	endothelin 1	Rattus norvegicus	34-38
10437863-1	1999	BACKGROUND: Stratum 2 of the Ramipril Efficacy in Nephropathy (REIN) study has already shown that in patients with chronic nephropathies and proteinuria of 3 g or more per 24 h, angiotensin-converting enzyme (ACE) inhibition reduced the rate of decline in glomerular filtration and halved the combined risk of doubling of serum creatinine or end-stage renal failure (ESRF) found in controls on placebo plus conventional antihypertensives.	Creatinine	328-338	angiotensin I converting enzyme	Homo sapiens	178-207
10437863-1	1999	BACKGROUND: Stratum 2 of the Ramipril Efficacy in Nephropathy (REIN) study has already shown that in patients with chronic nephropathies and proteinuria of 3 g or more per 24 h, angiotensin-converting enzyme (ACE) inhibition reduced the rate of decline in glomerular filtration and halved the combined risk of doubling of serum creatinine or end-stage renal failure (ESRF) found in controls on placebo plus conventional antihypertensives.	Creatinine	328-338	angiotensin I converting enzyme	Homo sapiens	209-212
10450860-0	1999	Association between AGT codon 235 polymorphism and variation in serum concentrations of creatinine and urea in Canadian Oji-Cree.	Creatinine	88-98	angiotensinogen	Homo sapiens	20-23
10450860-2	1999	We evaluated the association between common variation in the gene encoding angiotensinogen, AGT, and the serum concentrations of creatinine and urea in non-diabetic Canadian Oji-Cree.	Creatinine	129-139	angiotensinogen	Homo sapiens	75-90
10450860-5	1999	We found significant associations between the AGT codon 235 genotype and serum concentrations of creatinine and urea (p = 0.017 and 0.049, respectively) and systolic blood pressure (p = 0.041).	Creatinine	97-107	angiotensinogen	Homo sapiens	46-49
10450860-6	1999	Compared with subjects with the other two genotypes, homozygotes for AGT T235/T235 had significantly lower serum concentrations of creatinine and urea and significantly higher mean systolic blood pressure.	Creatinine	131-141	angiotensinogen	Homo sapiens	69-72
10372218-11	1999	A tobramycin clearance below 80 ml/min/1.73 m2 was associated with average 80% and 33% higher creatinine clearance values according to the Cockcroft-method and the direct method, respectively.	Creatinine	94-104	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
10201017-11	1999	The mean creatinine clearance declined over the years from 76 to 45 ml/min/1.73 m2, and the incidence of hypertension increased to more than 80% of the patients.	Creatinine	9-19	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
10102918-0	1999	Beta-trace protein in serum: a new marker of glomerular filtration rate in the creatinine-blind range.	Creatinine	79-89	prostaglandin D2 synthase	Homo sapiens	0-18
10333344-7	1999	In addition, the insulin resistance index had a positive relationship with overall creatinine clearance.	Creatinine	83-93	insulin	Homo sapiens	17-24
10333344-9	1999	These results showed that insulin resistance might participate in the genesis of sodium sensitivity in essential hypertension by enhancing tubular sodium reabsorption, as reflected in decreased FE(Na) and augmented creatinine clearance.	Creatinine	215-225	insulin	Homo sapiens	26-33
10100072-7	1999	Although serum angiotensin converting enzyme activity was higher in the deletion/deletion than in the other two genotypes (insertion/insertion 9.7 +/- 0.7, insertion/deletion 10.7 +/- 0.9, deletion/deletion 14.0 +/- 2.4 IU/I; P &lt; 0.05), other factors of the renin-angiotensin system, including blood pressure and serum creatinine levels, were not different among the three groups.	Creatinine	322-332	angiotensin I converting enzyme	Homo sapiens	15-44
10078892-10	1999	By comparison, ACE inhibition conferred meaningful clinical benefit among those whose creatinine was &lt; or = 1.9 mg/dL.	Creatinine	86-96	angiotensin I converting enzyme	Homo sapiens	15-18
10231450-7	1999	RESULTS: Considering an inulin clearance of less than 80 ml/min/1.73 m2, the cut-off value for serum creatinine was 11.5 mumol/liter for men and 90 mumol/liter for women.	Creatinine	101-111	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
10030290-2	1999	Cox proportional hazards regression analysis identified five variables that demonstrated independent simultaneous prognostic value in estimating patient survival after retransplantation: (1) age group (pediatric or adult), (2) recipient requiring preoperative mechanical ventilation, (3) donor organ cold ischemia &gt; or =12 hr, (4) preoperative serum creatinine, and (5) preoperative serum total bilirubin.	Creatinine	353-363	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
9817704-8	1998	In contrast, whereas the clearances of both CC16 and cystatin C were related to that of creatinine (p &lt; 0.02 for both), the clearances of SP-A and SP-B were not.	Creatinine	88-98	cystatin C	Homo sapiens	53-63
9713010-7	1998	Patients currently on gentamicin inhalation (n = 20) were significantly younger and had higher urinary NAG activity (0.83 (0.57) U/mmol creatinine) than the 23 patients without gentamicin inhalation (0.26 (0.10) (p = 0.0001) and the nine patients with previous gentamicin inhalation (0.32 (0.15) (p = 0.0125).	Creatinine	136-146	O-GlcNAcase	Homo sapiens	103-106
9705037-9	1998	Partial correlations of SBP and DBP with the 3-day averages were 0.257 (P &lt; 0.01) and 0.210 (P &lt; 0.05) for sodium; 0.223 (P &lt; 0.05) and 0.222 (P &lt; 0.05) for potassium; 0.127 and 0.091 for urinary volume; and -0.033 and 0.014 for creatinine.	Creatinine	241-251	selenium binding protein 1	Homo sapiens	24-27
10052717-3	1999	HGF levels correlated with the presence of disseminated intravascular coagulation (DIC), levels of lysozyme, creatinine, peripheral blood blast counts and lactic dehydrogenase.	Creatinine	109-119	hepatocyte growth factor	Homo sapiens	0-3
10085451-3	1999	Within the follow-up period, the mean serum creatinine values were significantly higher in FSGS recipients as compared with the control group (p = 0.02).	Creatinine	44-54	actinin alpha 4	Homo sapiens	91-95
10604239-4	1999	At a cut-off level of 1.74 mg/l for cystatin C and 1.81 U/g creatinine for NAG (95% percentile of the normoalbuminuric group), the sensitivity of the tests for detecting microalbuminuria was 82% for cystatin C and 86% for NAG.	Creatinine	60-70	O-GlcNAcase	Homo sapiens	75-78
10751050-11	1999	The mean creatinine level at the final point of the AS 0 group was significantly lower than in the combined AS 1 and AS 2 group (serum creatinine 1.44 +/- 1.03 vs 1.87 +/- 1.53 mg/dL: p &lt; 0.01).	Creatinine	9-19	prostaglandin D2 receptor	Homo sapiens	108-112
9832639-7	1998	In addition, MBP-positive cases showed marked mesangial cell proliferation, lower creatinine clearance (53.4 +/- 10.0 vs. 77.	Creatinine	82-92	myelin basic protein	Homo sapiens	13-16
9773781-9	1998	This increase in serum creatinine was significantly lower in ICAM-1 knockout mice: 27 (day -7) and 36 micromol/L (day 28).	Creatinine	23-33	intercellular adhesion molecule 1	Mus musculus	61-67
9826891-5	1998	Creatinine using the Jaffe method had a much stronger relationship with median beta-core hCG than the other measures.	Creatinine	0-10	chorionic gonadotropin subunit beta 5	Homo sapiens	89-92
9826891-7	1998	We conclude that when screening with urinary beta-core hCG measuring creatinine appears to be an adequate method of allowing for variable urine concentration.	Creatinine	69-79	chorionic gonadotropin subunit beta 5	Homo sapiens	55-58
9748573-6	1998	Intravenously administered DAO markedly inhibited the reperfusion-induced increase in vascular permeability, preserved the structure of the kidney and normalized the rate of clearance of PSP and creatinine.	Creatinine	195-205	amine oxidase, copper containing 1	Rattus norvegicus	27-30
9873839-5	1998	Mean +/- SD values of urinary NAG in seropositive RA patients, in seronegative RA patients and in normal healthy subjects were found to be 4.20 +/- 3.73 U/g creatinine, 2.96 +/- 2.11 U/gm creatinine, and 1.71 +/- 0.6 U/g creatinine, respectively.	Creatinine	157-167	O-GlcNAcase	Homo sapiens	30-33
9873839-5	1998	Mean +/- SD values of urinary NAG in seropositive RA patients, in seronegative RA patients and in normal healthy subjects were found to be 4.20 +/- 3.73 U/g creatinine, 2.96 +/- 2.11 U/gm creatinine, and 1.71 +/- 0.6 U/g creatinine, respectively.	Creatinine	188-198	O-GlcNAcase	Homo sapiens	30-33
9873839-5	1998	Mean +/- SD values of urinary NAG in seropositive RA patients, in seronegative RA patients and in normal healthy subjects were found to be 4.20 +/- 3.73 U/g creatinine, 2.96 +/- 2.11 U/gm creatinine, and 1.71 +/- 0.6 U/g creatinine, respectively.	Creatinine	188-198	O-GlcNAcase	Homo sapiens	30-33
9725817-4	1998	Within 4 h of nephrectomy, plasma leptin concentrations increased from 2.9 +/- 0.8 to 5.8 +/- 1.0 &amp; microg/l but thereafter rapidly (&lt;24 h) decreased to prenephrectomy concentrations, despite continued elevated plasma creatinine levels.	Creatinine	225-235	leptin	Rattus norvegicus	34-40
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	198-208	O-GlcNAcase	Homo sapiens	59-62
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	198-208	O-GlcNAcase	Homo sapiens	26-57
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	198-208	O-GlcNAcase	Homo sapiens	59-62
9749974-10	1998	The prevalence of "elevated" NAG (&gt;7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23.5%), then among nickel-chrome workers (7.1%) and aluminum workers (8.7%).	Creatinine	45-55	O-GlcNAcase	Homo sapiens	29-32
9644270-6	1998	The method was used to determine the urinary Ac-PA levels in healthy subjects, the average value of 0.36 microg of 2Ac-Spm/g creatinine (n = 16) being obtained.	Creatinine	125-135	proteinase 3	Homo sapiens	45-50
9625061-1	1998	Measurement of blood concentrations of cystatin C (cysC), a cysteine protease inhibitor present in human plasma, has been suggested for use as an indicator of glomerular filtration rate (GFR) in a manner analogous to the use of plasma creatinine (SCR).	Creatinine	235-245	cystatin C	Homo sapiens	39-49
9625061-1	1998	Measurement of blood concentrations of cystatin C (cysC), a cysteine protease inhibitor present in human plasma, has been suggested for use as an indicator of glomerular filtration rate (GFR) in a manner analogous to the use of plasma creatinine (SCR).	Creatinine	235-245	cystatin C	Homo sapiens	51-55
9693935-6	1998	Plasma Lp(a) values were significantly higher only in patients with creatinine clearance &lt; 70 mL min-1.	Creatinine	68-78	lipoprotein(a)	Homo sapiens	7-12
9460083-4	1998	In contrast, anti-OPN treatment significantly reduced glomerular injury (urinary protein excretion) and prevented a loss of renal function (creatinine clearance) during the induction of disease.	Creatinine	140-150	secreted phosphoprotein 1	Rattus norvegicus	18-21
10216370-16	1998	Patients with higher concentrations of serum creatinine during UTI had high urine levels of IL-8.	Creatinine	45-55	alpha-1-microglobulin/bikunin precursor	Homo sapiens	63-66
9509568-6	1998	A correlation was observed respectively between fibrinopeptide A (r = 0.34, p &lt; .05), beta-thromboglobulin (r = 0.39, p &lt; .05) and the beta-thromboglobulin/creatinine coefficient (0.50 +/- 0.30, r = 0.72, p &lt; .001) on the one side and the thrombin-antithrombin III complex on the other.	Creatinine	162-172	pro-platelet basic protein	Homo sapiens	89-109
9509568-6	1998	A correlation was observed respectively between fibrinopeptide A (r = 0.34, p &lt; .05), beta-thromboglobulin (r = 0.39, p &lt; .05) and the beta-thromboglobulin/creatinine coefficient (0.50 +/- 0.30, r = 0.72, p &lt; .001) on the one side and the thrombin-antithrombin III complex on the other.	Creatinine	162-172	pro-platelet basic protein	Homo sapiens	141-161
9870291-4	1998	The NAG excretion was higher in patients with urolithiasis (3.5 +/- 0.51 U/g creatinine) as compared with healthy subjects (1.33 +/- 0.14 U/g creatinine, P &lt; 0.05).	Creatinine	77-87	O-GlcNAcase	Homo sapiens	4-7
9870291-4	1998	The NAG excretion was higher in patients with urolithiasis (3.5 +/- 0.51 U/g creatinine) as compared with healthy subjects (1.33 +/- 0.14 U/g creatinine, P &lt; 0.05).	Creatinine	142-152	O-GlcNAcase	Homo sapiens	4-7
9489955-5	1997	Although correlations between glomerular deposition of PAS positive material and serum creatinine tended to be positive in MPGN, IgAN and MCGN-I, they were weak and not significant.	Creatinine	87-97	IGAN1	Homo sapiens	129-133
9403587-7	1997	Endothelin-1 also increased microvascular permeability both systemically and within the kidney, as suggested by marked increases in hematocrit (0.27+/-0.01 to 0.32+/-0.01) and urinary protein concentration (0.95+/-0.1 to 7.9+/-3.2 mg/mL per mg creatinine).	Creatinine	244-254	EDN1	Ovis aries	0-12
9397096-8	1997	Both median (range) urinary complete hCG-creatinine and beta-core fragment-creatinine ratios were significantly higher in preeclamptic women than in normotensive women (37.6 [0.5-185] versus 11.3 [1.9-54], P = .013; and 11.8 [2-67] versus 5.3 [0.3-29], P = .009, respectively).	Creatinine	41-51	chorionic gonadotropin subunit beta 5	Homo sapiens	37-40
9640077-4	1997	Urinary activity of plasmin was significantly elevated in diabetic patients with albuminuria as compared to subjects without microalbuminuria and healthy control (0.477 +/- 0.37 vs. 0.194 +/- 0.09 vs. 0.21 +/- 0.02 mlU/mg creatinine, p &lt; 0.01).	Creatinine	222-232	plasminogen	Homo sapiens	20-27
9640082-3	1997	Abnormal NAG values (&gt; 70 nmol/mg of creatinine) were found in 60 (95.2%) patients with chronic renal failure and the median of all values was 327.8 nmol/mg of creatinine.	Creatinine	40-50	O-GlcNAcase	Homo sapiens	9-12
9640082-3	1997	Abnormal NAG values (&gt; 70 nmol/mg of creatinine) were found in 60 (95.2%) patients with chronic renal failure and the median of all values was 327.8 nmol/mg of creatinine.	Creatinine	163-173	O-GlcNAcase	Homo sapiens	9-12
9640082-7	1997	However, the incidence of patients with NAG values higher than 280 nmol/mg of creatinine was statistically significant in unstable course of renal insufficiency and raised serum creatinine levels.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	40-43
9640082-7	1997	However, the incidence of patients with NAG values higher than 280 nmol/mg of creatinine was statistically significant in unstable course of renal insufficiency and raised serum creatinine levels.	Creatinine	178-188	O-GlcNAcase	Homo sapiens	40-43
9536599-4	1997	There was a significant negative correlation between the creatinine clearance and 24-hour urinary NAG (r = -0.38, p &lt; 0.05).	Creatinine	57-67	O-GlcNAcase	Homo sapiens	98-101
9336420-10	1997	CSA treatment resulted in a small increase in serum creatinine levels, but only 1 patient was withdrawn from the study for this reason.	Creatinine	52-62	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
9179085-8	1997	Serum levels of creatinine were significantly higher three to five days after transplantation in both groups who received N-CSA.	Creatinine	16-26	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	124-127
9179085-9	1997	Creatinine levels were also higher between days 13 and 14 in patients who received N-CSA and intravenous CSA.	Creatinine	0-10	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	85-88
9179085-9	1997	Creatinine levels were also higher between days 13 and 14 in patients who received N-CSA and intravenous CSA.	Creatinine	0-10	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	105-108
10357114-7	1999	The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	9-12
9179085-10	1997	Oral administration of N-CSA was stopped temporarily in two patients (20%) who received intravenous CSA because of a sudden decrease in urine output and rise in serum creatinine.	Creatinine	167-177	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	25-28
9179085-10	1997	Oral administration of N-CSA was stopped temporarily in two patients (20%) who received intravenous CSA because of a sudden decrease in urine output and rise in serum creatinine.	Creatinine	167-177	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	100-103
9077523-5	1997	alpha-MSH significantly reduced ischemia-induced renal damage, measured by changes in renal histology and plasma blood urea nitrogen and creatinine in mice.	Creatinine	137-147	pro-opiomelanocortin-alpha	Mus musculus	0-9
10357114-7	1999	The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24.	Creatinine	107-117	O-GlcNAcase	Homo sapiens	9-12
10357114-7	1999	The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24.	Creatinine	107-117	O-GlcNAcase	Homo sapiens	73-76
10357114-7	1999	The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24.	Creatinine	107-117	O-GlcNAcase	Homo sapiens	9-12
10357114-7	1999	The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24.	Creatinine	107-117	O-GlcNAcase	Homo sapiens	73-76
9890323-0	1999	Serum cystatin C as a determinant of fasting total homocysteine levels in renal transplant recipients with a normal serum creatinine.	Creatinine	122-132	cystatin C	Homo sapiens	6-16
9024272-12	1997	Serum bone alkaline phosphatase and urinary N-terminal telopeptide of type I collagen/creatinine levels decreased significantly after increasing the dose of hCG.	Creatinine	86-96	hypertrichosis 2 (generalised, congenital)	Homo sapiens	157-160
9453010-8	1998	Both glomerular and tubular OPN expression correlated significantly with proteinuria (P &lt; 0.001) and a reduction in creatinine clearance (P &lt; 0.01).	Creatinine	119-129	secreted phosphoprotein 1	Rattus norvegicus	28-31
9890323-2	1999	In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine levels (i.e., &lt; or = 1.5 mg/dl), serum cystatin C, a more sensitive indicator of GFR, would better predict fasting total homocysteine levels compared with serum creatinine.	Creatinine	92-102	cystatin C	Homo sapiens	145-155
9890323-2	1999	In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine levels (i.e., &lt; or = 1.5 mg/dl), serum cystatin C, a more sensitive indicator of GFR, would better predict fasting total homocysteine levels compared with serum creatinine.	Creatinine	267-277	cystatin C	Homo sapiens	145-155
9890323-4	1999	General linear modeling with analysis of covariance revealed that serum cystatin C was independently predictive (partial R = 0.494; P = 0.023) of fasting total homocysteine levels after adjustment for age, gender, vitamin status, albumin, and creatinine levels.	Creatinine	243-253	cystatin C	Homo sapiens	72-82
9890323-6	1999	Serum cystatin C levels may reflect subtle decreases in renal function that independently predict fasting total homocysteine levels among stable renal transplant recipients with a normal serum creatinine.	Creatinine	193-203	cystatin C	Homo sapiens	6-16
9924362-5	1998	Possible CsA adverse effects were monitored by routine biochemistry (including serum creatinine) and haematological tests, blood pressure recordings, and symptoms.	Creatinine	85-95	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	9-12
9285147-5	1997	There was a significant positive correlation between serum cystatin C and creatinine levels (r = 0.936, p &lt; 0.001) in the patients with various renal diseases.	Creatinine	74-84	cystatin C	Homo sapiens	59-69
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	21-31	cystatin C	Homo sapiens	138-148
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	6-16
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	138-148
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	6-16
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	138-148
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	6-16
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	138-148
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	6-16
9285147-6	1997	Serum cystatin C and creatinine inversely and logarithmically correlated to creatinine clearance as shown in the following equations: log cystatin C = -0.564 x log creatinine clearance + 1.216 (r = -0.850), log creatinine = -0.678 x log creatinine clearance + 1.449 (r = -0.904).	Creatinine	76-86	cystatin C	Homo sapiens	138-148
9285147-8	1997	The range for cystatin C is 0.67-6.15 mg/l, 0.66-7.23 mg/dl for creatinine and 8.9-186.3 l/day (6.2-129.4 ml/min) for creatinine clearance.	Creatinine	118-128	cystatin C	Homo sapiens	14-24
9285147-9	1997	Serum cystatin C levels started to increase over normal range when creatinine clearance fell below 135.9 l/day (94.4 ml/min), while serum creatinine remained within normal ranges.	Creatinine	67-77	cystatin C	Homo sapiens	6-16
9285147-10	1997	The daily urinary excretion of cystatin C was increased significantly in the group in which creatinine clearance was below 30 l/day (20.8 ml/min) compared to that in which creatinine clearance was higher than in 70 l/day (48.6 ml/min).	Creatinine	92-102	cystatin C	Homo sapiens	31-41
9285147-10	1997	The daily urinary excretion of cystatin C was increased significantly in the group in which creatinine clearance was below 30 l/day (20.8 ml/min) compared to that in which creatinine clearance was higher than in 70 l/day (48.6 ml/min).	Creatinine	172-182	cystatin C	Homo sapiens	31-41
9285147-11	1997	Fractional clearance of cystatin C increased proportionally and markedly to the decrease of creatinine clearance.	Creatinine	92-102	cystatin C	Homo sapiens	24-34
8751586-7	1996	RESULTS: Compared with dogs that received kidneys preserved in the vehicle, dogs receiving the IGF-I preserved kidneys had significantly lower daily serum creatinine and blood urea nitrogen levels during the course of 5 days after transplantation.	Creatinine	155-165	insulin like growth factor 1	Canis lupus familiaris	95-100
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	141-151	O-GlcNAcase	Homo sapiens	26-57
9275437-5	1996	(2) There was a positive correlation between NAG and protein/creatinine (Pr/Cr) ratio in random urine.	Creatinine	61-71	O-GlcNAcase	Homo sapiens	45-48
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	141-151	O-GlcNAcase	Homo sapiens	59-62
9749974-9	1998	Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).	Creatinine	198-208	O-GlcNAcase	Homo sapiens	26-57
8837222-4	1996	A significant correlation was noted between 24-h urinary excretion of immunoreactive human BNP and creatinine clearance in patients with various renal diseases (r = -0.43, P &lt; 0.01, n = 45).	Creatinine	99-109	natriuretic peptide B	Homo sapiens	91-94
8831085-1	1996	UNLABELLED: Raised urinary levels of albumin and N-acetyl-beta-D-glucosaminidase (NAG) are predictive of abnormal renal function and excretion of these substances is often expressed as a creatinine ratio.	Creatinine	187-197	O-GlcNAcase	Homo sapiens	82-85
9555663-4	1998	Serum creatinine increased significantly at 12 and 24 h, indicative of acute renal failure, but decreased substantially by 48 h. mRNA levels for the NHE-3 Na/H exchanger of the proximal tubule, the apical Na-K-2Cl cotransporter of the thick ascending limb of Henle, the Na-Cl cotransporter of the distal convoluted tubule, the epithelial Na+ channel of the collecting duct, and the basolateral Na(+)-K(+)-ATPase were measured by Northern hybridization.	Creatinine	6-16	solute carrier family 9 member A3	Rattus norvegicus	149-154
8639257-3	1996	In patients with acute rejection, the serum HGF level was markedly increased (over 1 ng/ml), and its elevation was accompanied by an increase in serum creatinine and blood urea nitrogen (BUN).	Creatinine	151-161	hepatocyte growth factor	Homo sapiens	44-47
9261317-12	1997	Reduction of CSA dosage resulted in normalization of serum creatinine level.	Creatinine	59-69	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	13-16
9574456-7	1998	The results of this study demonstrate that serum cystatin C significantly increases in renal transplant patients with reduced creatinine clearance (&lt; 70 mL/min per 1.73 m2) and that the diagnostic accuracy of serum cystatin C is better than of serum creatinine.	Creatinine	126-136	cystatin C	Homo sapiens	49-59
9271144-1	1997	N-Acetyl-beta-glucosaminidase (NAG), a glycosidase enzyme, present in serum, urine and the renal lysosomes is utilized clinically as an early marker for renal damage preceding the elevation of both blood urea nitrogen and creatinine.	Creatinine	222-232	O-GlcNAcase	Homo sapiens	0-29
9271144-1	1997	N-Acetyl-beta-glucosaminidase (NAG), a glycosidase enzyme, present in serum, urine and the renal lysosomes is utilized clinically as an early marker for renal damage preceding the elevation of both blood urea nitrogen and creatinine.	Creatinine	222-232	O-GlcNAcase	Homo sapiens	31-34
9214406-14	1997	The independent association between interstitial PI and serum creatinine (beta = 0.64) was also found in IgAN.	Creatinine	62-72	IGAN1	Homo sapiens	105-109
9247674-3	1997	Urinary hTNAP/creatinine (hTNAP/cr) in severe pre-eclampsia and eclampsia were significantly higher than in controls.	Creatinine	14-24	TNAP	Homo sapiens	26-31
11850697-15	1995	The magnitude of the pharmacokinetic changes for CSA during dirithromycin treatment (&lt;15% in normal subjects and 15--20% in renal transplant patients) when considered in the context of the therapeutic range of cyclosporine concentrations was relatively small, and not likely to warrant special attention to the dosing of CSA in such patients beyond routine whole-blood CSA and serum creatinine monitoring.	Creatinine	386-396	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	49-52
9574456-7	1998	The results of this study demonstrate that serum cystatin C significantly increases in renal transplant patients with reduced creatinine clearance (&lt; 70 mL/min per 1.73 m2) and that the diagnostic accuracy of serum cystatin C is better than of serum creatinine.	Creatinine	253-263	cystatin C	Homo sapiens	49-59
9623340-9	1998	Creatinine clearance was in negative correlation with TNF alpha concentrations in urine of our patients with IgAN.	Creatinine	0-10	IGAN1	Homo sapiens	109-113
9540760-6	1998	In both models, calcium level (RR 2.33), performance status (RR 1.83), and creatinine (RR 1.69) maintained their independent negative prognostic value.	Creatinine	75-85	ribonucleotide reductase catalytic subunit M1	Homo sapiens	87-91
9274837-9	1997	Creatinine clearance overestimated GFR in IgAN.	Creatinine	0-10	IGAN1	Homo sapiens	42-46
7735390-4	1995	The urinary activity of NAG-B showed a dose related increase that was already significant in the group excreting 0.5-2 micrograms Cd/g creatinine.	Creatinine	135-145	O-GlcNAcase	Homo sapiens	24-27
7749995-8	1995	NAG is one of the recommended tools for detecting minimum renal effects under 10 micrograms/g.creatinine of Cd.	Creatinine	94-104	O-GlcNAcase	Homo sapiens	0-3
7850304-8	1995	When those urine samples which were contaminated with bacteria and/or bilirubin were excluded, the beta-glucuronidase concentration (X ng/mumol creatinine) was significantly correlated with its maximal velocity (Y nmol/min/mumol creatinine): Y = 0.003 + 0.103X.	Creatinine	144-154	glucuronidase beta	Homo sapiens	99-117
7850304-8	1995	When those urine samples which were contaminated with bacteria and/or bilirubin were excluded, the beta-glucuronidase concentration (X ng/mumol creatinine) was significantly correlated with its maximal velocity (Y nmol/min/mumol creatinine): Y = 0.003 + 0.103X.	Creatinine	229-239	glucuronidase beta	Homo sapiens	99-117
7850304-9	1995	Contrary to blood urea nitrogen, which increases with the increase in serum creatinine, the urinary beta-glucuronidase activity and its concentration reached a peak at a serum creatinine of 1.6-3.0 mg/dL and declined at higher serum creatinine levels.	Creatinine	176-186	glucuronidase beta	Homo sapiens	100-118
7850304-9	1995	Contrary to blood urea nitrogen, which increases with the increase in serum creatinine, the urinary beta-glucuronidase activity and its concentration reached a peak at a serum creatinine of 1.6-3.0 mg/dL and declined at higher serum creatinine levels.	Creatinine	176-186	glucuronidase beta	Homo sapiens	100-118
7850304-10	1995	Episodic elevation of serum creatinine due to acute insult to the kidney or flare up of disease activity was often preceded by an increase in the level of urinary beta-glucuronidase.	Creatinine	28-38	glucuronidase beta	Homo sapiens	163-181
7759841-7	1995	However, after a further 3 weeks the renin concentration was slightly above the normal level, and this increase was accompanied by a decrease in body weight and increases in blood urea nitrogen, plasma creatinine, urinary protein and omega 3-subtype benzodiazepine receptor binding in the cerebral cortex, and by brain oedema.	Creatinine	202-212	renin	Rattus norvegicus	37-42
7731163-12	1995	Cystatin C measurement using PETIA technology can be automated on the same instruments used routinely for the measurement of creatinine and offers better analytical performance and probably improved clinical sensitivity as a screening test for early renal damage.	Creatinine	125-135	cystatin C	Homo sapiens	0-10
7477650-8	1995	The extent of this elevation was greater than that of the urinary N-acetyl-beta-D-glucosaminidase (NAG) activity/creatinine ratio (NAG/Cr).	Creatinine	113-123	O-GlcNAcase	Homo sapiens	131-134
9244413-7	1997	We conclude that CCV chemotherapy with autografting is tolerated well by extensively pre-treated myeloma patients provided the pre-transplant creatinine is normal, but toxicity in patients with abnormal renal function is high.	Creatinine	142-152	CCV	Homo sapiens	17-20
9339112-10	1997	Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion, which was described as the creatinine ratio, was significantly higher in the children with hypercalciuria.	Creatinine	84-94	O-GlcNAcase	Homo sapiens	8-39
9339112-10	1997	Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion, which was described as the creatinine ratio, was significantly higher in the children with hypercalciuria.	Creatinine	84-94	O-GlcNAcase	Homo sapiens	41-44
9183492-7	1997	In premature infants there was a significant positive correlation between A1M:creatinine ratio and RBP:creatinine ratio (r = 0.85), and also between albumin and both A1M and RBP (r = 0.82 and 0.77).	Creatinine	78-88	alpha-1-microglobulin/bikunin precursor	Homo sapiens	74-77
9183492-7	1997	In premature infants there was a significant positive correlation between A1M:creatinine ratio and RBP:creatinine ratio (r = 0.85), and also between albumin and both A1M and RBP (r = 0.82 and 0.77).	Creatinine	103-113	alpha-1-microglobulin/bikunin precursor	Homo sapiens	74-77
9225570-6	1997	In uremic patients, NHE was inversely correlated with creatinine clearance (r = -0.48, p = 0.03).	Creatinine	54-64	solute carrier family 9 member C1	Homo sapiens	20-23
8989127-5	1996	Urine volume and urine sodium excretion increased significantly during hBNP infusion when compared with placebo infusion (90 +/- 38 versus 67 +/- 27 mL/h and 2.6 +/- 2.4 versus 1.4 +/- 1.2 mEq/h, respectively, both P &lt; .05 versus placebo), whereas creatinine clearance and urinary potassium excretion did not change.	Creatinine	251-261	natriuretic peptide B	Homo sapiens	71-75
8840947-7	1996	The creatinine clearance at 6 months, 1 year, and 2 years following transplantation was 73.2 +/- 25.7 mL/min, 54.7 +/- 18.8 mL/min, and 57.0 +/- 32.0 mL/min, respectively, for patients successfully rechallenged with CsA compared with 67 +/- 17 mg/min, 71.8 +/- 21.2 mL/min, and 69 +/- 19 mg/min, respectively, for controls (P = NS).	Creatinine	4-14	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	216-219
8882615-11	1996	MAO-A inhibition during HS intake was found to produce a 47-68% decrease in Na+ excretion (from 39.1 +/- 0.7 to 15.1 +/- 2.5 mmol kg-1 day-1, n = 4; P &lt; 0.02) and urine volume (from 160.4 +/- 3.3 to 43.8 +/- 9.0 ml kg-1 day-1, n = 4; P &lt; 0.02) without changes in K+ (from 11.1 +/- 0.5 to 9.2 +/- 0.6 mmol kg-1 day-1, n = 4) and creatinine (from 29.1 +/- 2.3 to 28.4 +/- 2.1 mg kg-1 day-1) excretion; urine osmolality increased 2 fold (from 936.3 +/- 40.3 to 2210.7 +/- 157.4 mOsm kg-1 H2O, n = 4; P &lt; 0.02).	Creatinine	334-344	monoamine oxidase A	Rattus norvegicus	0-5
9105256-8	1997	The mean value for NAG isoenzyme B in spot urines from healthy adults was 2.9 micrograms/g creatinine.	Creatinine	91-101	O-GlcNAcase	Homo sapiens	19-22
9105763-6	1997	IgAN patients with positive TXS mRNA had significantly reduced GFR with elevated serum creatinine and serum beta 2-microglobulin levels.	Creatinine	87-97	IGAN1	Homo sapiens	0-4
9081681-9	1997	The corresponding values for urinary excretion of high-molecular-weight beta-thromboglobulin were 1.78 versus 1.92 ng/mmol creatinine.	Creatinine	123-133	pro-platelet basic protein	Homo sapiens	72-92
8943482-8	1996	Moreover, IgAN patients as a whole exhibited a reduction of EGF and an increase of IL-6 urinary concentration (EGF values: N, 12.96 +/- 1.15; IgAN Grades 1-2, 20.05 +/- 2.64; Grades 3-4 7.60 +/- 1.70: Grade 5, 3.14 +/- 0.71, ng/mg urinary creatinine.	Creatinine	239-249	IGAN1	Homo sapiens	10-14
8603584-4	1996	IGF-I treatment significantly increased plasma IGF-I concentrations, but reduced plasma concentrations of IGF-II, GH, urea, and creatinine.	Creatinine	128-138	insulin-like growth factor I	Ovis aries	0-5
8739528-10	1996	In hypertension, Lp(a) correlated with serum creatinine (r = 0.420, p = 0.03).	Creatinine	45-55	lipoprotein(a)	Homo sapiens	17-22
8610347-4	1996	Posttransplant urinary NAG excretion in the group of patients with failing grafts was significantly lower (9.4 +/- 6.3 vs. 17.2 +/- 8.5 U/g urinary creatinine, P = 0.036).	Creatinine	148-158	O-GlcNAcase	Homo sapiens	23-26
8538854-5	1995	However, a progressive increase in the blood urea nitrogen and serum creatinine associated with extensive glomerular sclerosis and hypertrophy was only observed in the ADR-NaC1 group.	Creatinine	69-79	nucleus accumbens associated 1	Rattus norvegicus	172-176
7770645-6	1995	When indexed to creatinine, a comparison of the urinary enzyme levels of control and sickle cell patients showed significant differences for beta-glucuronidase (p &lt; .01) and alpha-galactosidase (p &lt; .05) but not for the other three enzymes.	Creatinine	16-26	glucuronidase beta	Homo sapiens	141-159
7534496-8	1994	Also, the excretion of beta 2-microglobulin and N-acetyl-beta-glucosaminidase increased from 10.98 +/- 4.62 to 11.86 +/- 4.74 mg/24 h (P &lt; 0.05) and from 19.7 +/- 4.2 to 25.3 +/- 7.0 nmol/h per micromoles of creatinine (P = 0.05), respectively.	Creatinine	211-221	O-GlcNAcase	Homo sapiens	48-77
8610347-12	1996	Urinary NAG excretion was expressed as unit per gram of urinary creatinine; as the amount of NAG excreted depends on the graft mass, and the amount of urinary creatinine depends on the recipient body mass, a low NAG excretion (in terms of U/g urinary creatinine) could be a surrogate marker of an unfavorable low graft to body weight ratio, which, in turn, might be associated with a reduced graft survival.	Creatinine	64-74	O-GlcNAcase	Homo sapiens	8-11
8929824-5	1996	Controversial results were found for NAG activity: the normalization of values for amniotic fluid creatinine significantly changed the reduction pattern of this enzyme.	Creatinine	98-108	O-GlcNAcase	Homo sapiens	37-40
7759977-5	1994	There was direct relationship between serum TCII levels and BUN or creatinine levels.	Creatinine	67-77	transcobalamin 2	Homo sapiens	44-48
7696107-9	1994	The urine NAG/creatinine quotient in the children &lt; 1 year showed, however, a significant correlation with the DMSA score (r = 0.58, P &lt; 0.05), while no correlation was found in the older children.	Creatinine	14-24	O-GlcNAcase	Homo sapiens	10-13
8026110-7	1994	Among all clinical and pathologic parameters examined, the following parameters were proved to be significant independent predictors of progression of IgAN: serum creatinine exceeding 1.5 mg/dl in men and 1.3 mg/dl in women, proteinuria over 2 g/day, segmental lesions involving more than 25% of glomeruli and interstitial fibrosis occupying more than 25% of cortical area.	Creatinine	163-173	IGAN1	Homo sapiens	151-155
9008022-8	1996	In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion.	Creatinine	171-181	O-GlcNAcase	Homo sapiens	25-28
9008022-8	1996	In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion.	Creatinine	171-181	O-GlcNAcase	Homo sapiens	98-101
8914044-3	1996	Compared to 50 age-matched controls of idiopathic FSGS with typical perihilar scars, the group of idiopathic collapsing FSGS displayed black racial predominance, a higher serum creatinine and more severe features of nephrotic syndrome at biopsy.	Creatinine	177-187	actinin alpha 4	Homo sapiens	120-124
8621208-6	1996	Rats given CsA for 6 days developed severe renal insufficiency, as shown by a 74% decrease in creatinine clearance rate (Ccr) (P &lt; .006).	Creatinine	94-104	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	11-14
8627207-8	1996	CONCLUSIONS: We conclude that the protein/creatinine ratio of a single voided urine specimen may have a role in the management of ambulatory women with suspected PIH, although further study is needed.	Creatinine	42-52	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	162-165
8742174-9	1996	Since the technique proved to be able to identify activated eosinophils bearing the CD69 early activation antigen, the relation between serum creatinine and CD69 expression on peripheral blood eosinophils was analysed showing a positive correlation (r = 0.4344, P = 0.016).	Creatinine	142-152	CD69 molecule	Homo sapiens	84-88
7645026-17	1995	In a multiple regression analysis, ALDH2 and the drinking habit were significantly (p &lt; 0.01) associated with HA excretion after toluene exposure with and without correction for creatinine, and the corrected HA concentration was also significantly (p &lt; 0.01) increased in the Ile/Val and Val/Val group of CYP1A1.	Creatinine	181-191	aldehyde dehydrogenase 2 family member	Homo sapiens	35-40
7825976-5	1994	For all patients, AUC, CIT, Vdss, t1/2 beta and MRT were significantly correlated with creatinine clearance; the different pharmacokinetic parameters calculated showed great interindividual variations.	Creatinine	87-97	interleukin 1 receptor like 1	Homo sapiens	34-43
7851056-6	1994	As histamine H2-receptor antagonists and pirenzepine are mainly eliminated by the renal route their elimination is dependent on creatinine clearance.	Creatinine	128-138	histamine receptor H2	Homo sapiens	3-24
8205941-5	1994	Urinary levels of the brush border enzyme N-acetyl-beta-D-glucosaminidase (NAG), a marker of tubular dysfunction, were initially raised and fell significantly after 8 months" treatment with captopril (20.3 +/- 14.4 vs 8.8 +/- 8.1 U/g creatinine; P &lt; 0.01).	Creatinine	234-244	O-GlcNAcase	Homo sapiens	42-73
8205941-5	1994	Urinary levels of the brush border enzyme N-acetyl-beta-D-glucosaminidase (NAG), a marker of tubular dysfunction, were initially raised and fell significantly after 8 months" treatment with captopril (20.3 +/- 14.4 vs 8.8 +/- 8.1 U/g creatinine; P &lt; 0.01).	Creatinine	234-244	O-GlcNAcase	Homo sapiens	75-78
7933809-6	1994	Endogenous levels of EGF closely paralleled serum creatinine with a six-fold increase observed at peak injury.	Creatinine	50-60	epidermal growth factor like 1	Rattus norvegicus	21-24
8183913-3	1994	Intravenous injection of recombinant human HGF into mice remarkably suppressed increases in blood urea nitrogen and serum creatinine caused by administration of cisplatin, a widely used antitumor drug, or HgCl2, thereby indicating that HGF strongly prevented the onset of acute renal dysfunction.	Creatinine	122-132	hepatocyte growth factor	Homo sapiens	43-46
8185690-8	1994	The serum creatinine level increased by 13 mumoles/liter (95% confidence interval [95% CI] 4, 22) in the CSA group and by 6 mumoles/liter (95% CI 1, 11) in the CQ group (difference not statistically significant).	Creatinine	10-20	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	105-108
8175974-2	1994	Compared to placebo, BNP induced significant increases in effective renal plasma flow (para-aminohippurate clearance), glomerular filtration rate (creatinine clearance), urine flow rate, and sodium excretion without affecting blood pressure, heart rate, cardiac output (echocardiographic method), peripheral vascular resistance, PRA, plasma aldosterone, or plasma norepinephrine to any significant extent.	Creatinine	147-157	natriuretic peptide B	Homo sapiens	21-24
8072258-8	1994	In patients with FSGS on RB1 and RB2, serum creatinine at the end of CsA treatment was 130.6 +/- 60.1 mumol/liter, significantly greater (P = 0.022) than the corresponding levels in the subset with MCD (87.3 +/- 24.8).	Creatinine	44-54	RB transcriptional corepressor 1	Homo sapiens	25-28
7816254-8	1994	The intensity of the interstitial alpha-SMA staining correlated with renal functional outcome; inversely with the reciprocal of serum creatinine slopes (r = -0.466, P &lt; 0.025) and positively with the serum creatinine value at the end of the observation period (r = 0.704, P &lt; 0.001).	Creatinine	134-144	survival of motor neuron 1, telomeric	Homo sapiens	40-43
7816254-8	1994	The intensity of the interstitial alpha-SMA staining correlated with renal functional outcome; inversely with the reciprocal of serum creatinine slopes (r = -0.466, P &lt; 0.025) and positively with the serum creatinine value at the end of the observation period (r = 0.704, P &lt; 0.001).	Creatinine	209-219	survival of motor neuron 1, telomeric	Homo sapiens	40-43
8052374-5	1994	Forty-eight hours after toxic injury, urinary immunoreactive EGF levels in HgCl2-treated rats decreased significantly compared with control rats (1.62 +/- 0.15 versus 3.78 +/- 0.21 ng/mg creatinine; p &lt; 0.01).	Creatinine	187-197	epidermal growth factor like 1	Rattus norvegicus	61-64
8052374-6	1994	Urinary immunoreactive EGF was at its lowest level 96 h after toxic injury (0.64 +/- 0.06 ng/mg creatinine; p &lt; 0.001).	Creatinine	96-106	epidermal growth factor like 1	Rattus norvegicus	23-26
7885789-2	1994	The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients.	Creatinine	24-34	O-GlcNAcase	Homo sapiens	76-107
7885789-2	1994	The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients.	Creatinine	24-34	O-GlcNAcase	Homo sapiens	109-112
7885789-7	1994	The urine excretion of NAG and albumin, reflecting renal dysfunction, was associated with values of both urine IL-6 and IL-8/creatinine quotients, but not with DMSA defects or VUR.	Creatinine	125-135	O-GlcNAcase	Homo sapiens	23-26
8073221-3	1994	Blood urea nitrogen and the N-acetyl-beta-glucosaminidase (NAG): creatinine ratio were slightly elevated at day 4 while creatinine clearance was decreased.	Creatinine	65-75	O-GlcNAcase	Rattus norvegicus	59-62
11271272-7	1994	At time of kidney-biopsy proven rejection with a concurrent serum creatinine rise a significant HAT level rise to more than 1000 ng/ml was observed from baseline levels of 200 ng/ml (P &lt; 0.001) indicating kidney and pancreas rejection (73%).	Creatinine	66-76	transmembrane serine protease 11D	Homo sapiens	96-99
8238009-5	1993	The median urinary beta-galactosidase activity for the pregnant population, when expressed on the basis of creatinine, was twofold higher than that of the control group (P &lt; 0.0005).	Creatinine	107-117	galactosidase beta 1	Homo sapiens	19-37
8254868-4	1993	Creatinine clearance (CCr) on the 7th postoperative day and the difference of BUN/Cr between preoperative period and 30 min after initiation of cardiopulmonary bypass (delta BUN/Cr 30 min) correlated significantly with the postoperative NAG index.	Creatinine	0-10	O-GlcNAcase	Homo sapiens	237-240
8267020-4	1993	IL2R and beta 2M correlated with serum creatinine, but not with proteinuria.	Creatinine	39-49	interleukin 2 receptor subunit alpha	Homo sapiens	0-4
8267022-9	1993	Ccr, fractional excretion of NAG to creatinine, FENa and urine osmolality of group 1 infants were statistically significantly different when compared to those of group 2 and the control infants.	Creatinine	36-46	O-GlcNAcase	Homo sapiens	29-32
8434865-2	1993	The excretion of total protein, albumin and NAG (expressed in relation to creatinine excretion) increased significantly after the walk.	Creatinine	74-84	O-GlcNAcase	Homo sapiens	44-47
8428410-4	1993	The patients with FSGS had a significantly greater degree of mesangial expansion, glomerular basement membrane (GBM) thickening, interstitial fibrosis, and arteriolosclerosis, as well as an increased level of serum creatinine, when compared to the patients without.	Creatinine	215-225	actinin alpha 4	Homo sapiens	18-22
8499152-3	1993	Furthermore, TCM, histological grading of myeloma cells, degree of bone marrow infiltration, haemoglobin, platelet counts, calcium, creatinine, albumin, beta 2M, and Bence Jones proteinuria correlated to both OAS and TRS.	Creatinine	132-142	SPARC related modular calcium binding 1	Homo sapiens	209-212
8406937-4	1993	Probit regression analysis between urinary Cd excretion and, beta 2-mg-uria indicated that the threshold value may be set around 4 micrograms/g creatinine (cr.).	Creatinine	144-154	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	61-67
8423678-15	1993	IGF-I was increased in bGH mice; they also had an increased albumin/creatinine ratio at 6-9 months.	Creatinine	68-78	insulin-like growth factor 1	Mus musculus	0-5
1363243-8	1992	Urinary gamma-GTP activity in the patients did not differ from that in the controls, but urinary NAG/gamma-GTP ratio was higher in the patients, and reversely correlated with creatinine clearance (r = -0.721; p &lt; 0.01).	Creatinine	175-185	O-GlcNAcase	Homo sapiens	97-100
1444164-1	1992	A new, totally enzymatic procedure for the determination of creatinine in serum and urine, using creatinine amidohydrolase, creatine amidinohydrolase, sarcosine oxidase and formaldehyde dehydrogenase is described.	Creatinine	60-70	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	173-199
1424212-6	1992	In renal failure, PTHrP was positively correlated with serum creatinine, but PTHrP elevations of up to 30 pmol/l were found only in severe renal dysfunction with creatinine &gt; 850 mumol/l.	Creatinine	61-71	parathyroid hormone like hormone	Homo sapiens	18-23
1424212-6	1992	In renal failure, PTHrP was positively correlated with serum creatinine, but PTHrP elevations of up to 30 pmol/l were found only in severe renal dysfunction with creatinine &gt; 850 mumol/l.	Creatinine	162-172	parathyroid hormone like hormone	Homo sapiens	77-82
1547551-8	1992	The decrease in apo(a) in individual patients was significantly correlated with the increase in creatinine clearance (r = -0.48, P less than 0.001).	Creatinine	96-106	lipoprotein(a)	Homo sapiens	16-22
1563116-5	1992	We found a significant increase of plasma amylin when kidney function, expressed by creatinine clearance fell below 20 ml/min (17.9 +/- 1.7 vs. 12.2 +/- 0.8 vs. 8.8 +/- 1.2 pg/ml; p = 0.0005).	Creatinine	84-94	islet amyloid polypeptide	Homo sapiens	42-48
1962647-7	1991	In contrast, urinary NAG activity tended to be only slightly higher in patients with essential hypertension than in the normotensive control group (33 +/- 31 v 23 +/- 29 U/mg creatinine [cr], P = 0.062), whereas patients with renal diseases had clearly increased urinary NAG activity (87 +/- 105 U/mg cr) (P less than 0.001).	Creatinine	175-185	O-GlcNAcase	Homo sapiens	21-24
1962647-7	1991	In contrast, urinary NAG activity tended to be only slightly higher in patients with essential hypertension than in the normotensive control group (33 +/- 31 v 23 +/- 29 U/mg creatinine [cr], P = 0.062), whereas patients with renal diseases had clearly increased urinary NAG activity (87 +/- 105 U/mg cr) (P less than 0.001).	Creatinine	187-189	O-GlcNAcase	Homo sapiens	21-24
1750062-3	1991	In the absence of an existing quantitative measure to assess and compare the status of those grafts that function primarily, we defined the half-life of creatinine elimination (t1/2SCr) as such an outcome measure based on a review of creatinine elimination kinetics.	Creatinine	153-163	interleukin 1 receptor like 1	Homo sapiens	177-184
1750765-2	1991	The normal values obtained at 17-19 and 28-31 gestational weeks did not differ, and an activity of 105 units NAG/mmol creatinine was the upper limit of the normal range.	Creatinine	118-128	O-GlcNAcase	Homo sapiens	109-112
1794134-5	1991	Analysis indicated a median TGF-alpha value of 981 ng/g urinary creatinine for urine samples from cancer patients (range 608 to 1737) and 642 ng/g creatinine (range 417 to 941) for control urine samples.	Creatinine	64-74	transforming growth factor alpha	Homo sapiens	28-37
2063674-1	1991	Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine in 120 normal Chinese children.	Creatinine	126-136	O-GlcNAcase	Homo sapiens	21-50
2063674-1	1991	Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine in 120 normal Chinese children.	Creatinine	126-136	O-GlcNAcase	Homo sapiens	52-55
2063674-5	1991	Eleven longitudinal follow-up data including levels at diagnosis, end of treatment, and two to four weeks after treatment showed that the mean urinary NAG at diagnosis was 109.82 +/- 87.30 u/g creatinine, compared with 75.26 +/- 48.82 u/g creatinine at the end of treatment and 15.37 +/- 9.69 u/g creatinine after recovery.	Creatinine	193-203	O-GlcNAcase	Homo sapiens	151-154
2063674-5	1991	Eleven longitudinal follow-up data including levels at diagnosis, end of treatment, and two to four weeks after treatment showed that the mean urinary NAG at diagnosis was 109.82 +/- 87.30 u/g creatinine, compared with 75.26 +/- 48.82 u/g creatinine at the end of treatment and 15.37 +/- 9.69 u/g creatinine after recovery.	Creatinine	239-249	O-GlcNAcase	Homo sapiens	151-154
2063674-5	1991	Eleven longitudinal follow-up data including levels at diagnosis, end of treatment, and two to four weeks after treatment showed that the mean urinary NAG at diagnosis was 109.82 +/- 87.30 u/g creatinine, compared with 75.26 +/- 48.82 u/g creatinine at the end of treatment and 15.37 +/- 9.69 u/g creatinine after recovery.	Creatinine	239-249	O-GlcNAcase	Homo sapiens	151-154
2096199-3	1990	The sodium/creatinine ratio [r = 0.10 (P less than 0.001)] and sodium/potassium ratio [r = 0.11 (P less than 0.001)] were positively correlated with SBP.	Creatinine	11-21	selenium binding protein 1	Homo sapiens	149-152
2239931-13	1990	However, the slow, but relentless, increase in serum creatinine in the CSA-treated patients compared with those treated with AZA is of concern.	Creatinine	53-63	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	71-74
1982015-7	1990	The urinary DAP IV levels in patients with CRF were lower than those in patients with CGN and NS who had normal GFR, and there was a significant negative correlation between the urinary DAP IV levels and the serum creatinine levels.	Creatinine	214-224	death associated protein	Homo sapiens	186-189
33810966-0	2021	Serum creatinine to cystatin C ratio is associated with major adverse cardiovascular events in patients with obstructive coronary artery disease.	Creatinine	6-16	cystatin C	Homo sapiens	20-30
33810966-2	2021	Recently, the sarcopenia index (SI) was developed as a simple screening tool based upon the serum creatinine to cystatin C (CysC) ratio.	Creatinine	98-108	cystatin C	Homo sapiens	124-128
33810966-12	2021	CONCLUSIONS: Serum creatinine to cystatin C ratio (SI) may be a useful surrogate marker to predict the future prevalence of MACE in patients with obstructive CAD.	Creatinine	19-29	cystatin C	Homo sapiens	33-43
33810243-6	2021	T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates.	Creatinine	188-198	long intergenic non-protein coding RNA 2605	Homo sapiens	19-21
33810243-6	2021	T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates.	Creatinine	231-241	long intergenic non-protein coding RNA 2605	Homo sapiens	19-21
34549533-5	2022	RESULTS: The elevation of serum cystatin C was positively related to the elevation of serum creatinine (P < .001), LDH (P = .006), beta2-microglobulin (P < .001), bone marrow plasma cell proportion (P = .005) and the reduction of hemoglobin levels (P < .001).	Creatinine	92-102	cystatin C	Homo sapiens	32-42
34611952-5	2022	Gal-3 levels in dialysate effluent correlated with D/P creatinine (0.663, p = 0.005) and dialysate effluent IL-6 levels (0.674, p = 0.002), but not with serum Gal-3 levels or dialysis vintage.	Creatinine	55-65	galectin 3	Homo sapiens	0-5
34611952-8	2022	This study found Gal-3 in dialysate effluent correlated with D/P creatinine and dialysate IL-6 levels.	Creatinine	65-75	galectin 3	Homo sapiens	17-22
34967083-6	2022	Combining previously published urinary p75ECD results from 22 ALS patients with a further 24 ALS patients, baseline urinary p75ECD was also higher compared to healthy controls (6.0 +- 2.7 vs 3.2 +- 1.0 ng/mg creatinine p<0.0001) and correlated with ALSFRS-R (r= -0.36, p= 0.01).	Creatinine	208-218	PC4 and SFRS1 interacting protein 1	Homo sapiens	39-42
34923112-2	2021	However, the serum creatinine-to-cystatin-C ratio may be a better indicator of health status.	Creatinine	19-29	cystatin C	Homo sapiens	33-43
34923112-3	2021	The objective of this study was to describe the relationship between creatinine-to-cystatin-C ratio and all-cause mortality when stratifying patients according to race and according to chronic kidney disease status.	Creatinine	69-79	cystatin C	Homo sapiens	83-93
34923112-9	2021	In the fully adjusted model, compared to the reference (creatinine-to-cystatin-C ratio: 1.00-<1.25), a creatinine-to-cystatin-C ratio <0.75 had the highest mortality risk among both Black and non-Black Veterans (non-Black: HR (95%CI): 3.01(2.78-3.26) and Black: 4.17 (3.31-5.24)).	Creatinine	103-113	cystatin C	Homo sapiens	70-80
34923112-9	2021	In the fully adjusted model, compared to the reference (creatinine-to-cystatin-C ratio: 1.00-<1.25), a creatinine-to-cystatin-C ratio <0.75 had the highest mortality risk among both Black and non-Black Veterans (non-Black: HR (95%CI): 3.01(2.78-3.26) and Black: 4.17 (3.31-5.24)).	Creatinine	103-113	cystatin C	Homo sapiens	117-127
34923112-12	2021	CONCLUSIONS: Higher creatinine-to-cystatin-C ratios indicate better health status and are strongly associated with lower mortality risk regardless of kidney function level, and the relation was similar for both Black and non-Black Veterans, but with different strengths of effect across racial groups.	Creatinine	20-30	cystatin C	Homo sapiens	34-44
34918062-3	2022	The final report from the Task Force recommends calculating estimated glomerular filtration rate (eGFR) without a race coefficient using the recently published CKD-EPI 2021 creatinine and creatinine-cystatin C equations.	Creatinine	188-198	cystatin C	Homo sapiens	199-209
34861810-11	2021	The main bacteria linked to SBP and FGF23 also correlated directly with creatinine.	Creatinine	72-82	fibroblast growth factor 23	Rattus norvegicus	36-41
34738853-9	2021	Serum levels of gal-3 in all patients correlated with age (r = 0.36. p < .001), creatinine (r = 0.60, p < .001), NT-proBNP (r = 0.53, p < .001), RA area (r = 0.38, p < .001) and TAPSE (r = -0.3. p < .01).	Creatinine	80-90	galectin 3	Homo sapiens	16-21
34782198-1	2022	AIM: The creatinine-to-cystatin C ratio (CCR) has been acknowledged as a potential marker of muscle mass.	Creatinine	9-19	cystatin C	Homo sapiens	23-33
34912596-11	2021	A significant relationship was found between IgAN with increased serum creatinine and male sex (P = 0.017).	Creatinine	71-81	IGAN1	Homo sapiens	45-49
34554658-10	2021	New creatinine-cystatin C equations without race were more accurate than new creatinine equations, with smaller differences between race groups.	Creatinine	4-14	cystatin C	Homo sapiens	15-25
34764669-11	2021	Serum cytokines interleukin (IL)-6, IL-12/23p40 and macrophage chemoattractant protein (MCP)-1, and creatinine kinase (CK) were lower in aged IRF3-KO septic mice compared to WT counterparts.	Creatinine	100-110	interferon regulatory factor 3	Mus musculus	142-146
34917912-10	2022	Soluble VSIG4 in ascites exceeded serum concentrations and correlated with serum creatinine, model for end-stage liver disease score and C-reactive protein during SBP.	Creatinine	81-91	V-set and immunoglobulin domain containing 4	Homo sapiens	8-13
34727314-7	2021	Both age (r = 0.210, p = 0.001), serum creatinine (r = 0.509, p < 0.001), eGFR (r =  - 0.459, p < 0.001) and Hcy (r = 0.531, p < 0.001) were significantly correlated with HMGB1.	Creatinine	39-49	high mobility group box 1	Homo sapiens	171-176
34216521-0	2021	Venous creatinine as a biomarker for loss of fat-free mass and disease progression in patients with Amyotrophic Lateral Sclerosis.	Creatinine	7-17	FAT atypical cadherin 1	Homo sapiens	45-48
34216521-1	2021	BACKGROUND: To establish the utility of venous creatinine as a biomarker to monitor loss of fat-free mass in patients with amyotrophic lateral sclerosis (ALS).	Creatinine	47-57	FAT atypical cadherin 1	Homo sapiens	92-95
34216521-7	2021	Lower levels of venous creatinine were associated with increased risk for earlier death in patients with ALS (HR=0.94, CI: 0.90-0.98, p=0.007) CONCLUSIONS: Venous creatinine is decreased in ALS and declines alongside a decline in fat-free mass over the course of disease, and may serve as practical marker to monitor the change of fat-free mass in patients with ALS.	Creatinine	163-173	FAT atypical cadherin 1	Homo sapiens	331-334
34597711-9	2021	The ROC curve showed that the area under the curve of serum cystatin C was 0.893, the area under the curve of urocystatin C was 0.898, and the area under the curve of serum creatinine was 0.652.	Creatinine	173-183	cystatin C	Homo sapiens	60-70
34815797-6	2021	T-cell-specific BPI transgenic (Lck-BPI Tg) mice showed multi-tissue inflammation with early induction of serum IL-1beta levels, as well as serum triglyceride and creatinine levels.	Creatinine	163-173	lymphocyte protein tyrosine kinase	Mus musculus	32-35
34551678-8	2021	Glomerular filtration measured with CKD-EPI creatinine-cystatin C increased significantly in the RAL arm at week 24 through 48 but declined modestly in other two arms.	Creatinine	44-54	cystatin C	Homo sapiens	55-65
34392671-7	2021	The serum creatinine in IgAN group was higher than that in IgAVN group (P=0.02).	Creatinine	10-20	IGAN1	Homo sapiens	24-28
34246297-9	2021	Five of those miRNAs (hsa-miR-126-3p, hsa-miR-142-3p, hsa-miR-146a-5p, hsa-miR-155-5p, and hsa-miR-222-3p) also had a positive correlation with serum creatinine and therefore a negative correlation with eGFR.	Creatinine	150-160	microRNA 1263	Homo sapiens	22-36
34307526-6	2021	Supplementing 0.2% GAA into the diet increased the a* (redness) values, and b* (yellowness) values, and the amount of creatine kinase (CK), muscle glycogen, creatinine (CRE), and laminin (LN) in LT muscles.	Creatinine	157-167	alpha glucosidase	Homo sapiens	19-22
34307526-6	2021	Supplementing 0.2% GAA into the diet increased the a* (redness) values, and b* (yellowness) values, and the amount of creatine kinase (CK), muscle glycogen, creatinine (CRE), and laminin (LN) in LT muscles.	Creatinine	169-172	alpha glucosidase	Homo sapiens	19-22
35256230-1	2022	BACKGROUND AND AIMS: Low serum creatinine (Cr) to cystatin C (cysC) ratio has been suggested to be associated with low muscle mass and strength and poor prognosis in various chronic disease.	Creatinine	31-41	cystatin C	Homo sapiens	50-60
35606777-1	2022	BACKGROUND: The serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a marker for sarcopenia, but has not been studied in patients with idiopathic pulmonary fibrosis (IPF).	Creatinine	22-32	cystatin C	Homo sapiens	33-43
35249274-0	2022	Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study.	Creatinine	11-21	cystatin C	Homo sapiens	25-35
35249274-1	2022	Background: Creatinine-to-cystatin C ratio is recently suggested to be a surrogate marker for sarcopenia.	Creatinine	12-22	cystatin C	Homo sapiens	26-36
35249274-9	2022	The risk of diabetes was gradually and significantly decreased with increased normalized creatinine-cystatin C ratio.	Creatinine	89-99	cystatin C	Homo sapiens	100-110
35249274-10	2022	The multivariable-adjusted odds ratio for diabetes was 0.91 (95% confidence interval, 0.83 to 0.99) per 1 standard deviation higher of normalized creatinine-to-cystatin C ratio, and this relationship remained significant after controlling for muscle strength.	Creatinine	146-156	cystatin C	Homo sapiens	160-170
35249274-12	2022	Insulin resistance and inflammation appeared to be key mediators accounting for the observed relationship between normalized creatinine-to-cystatin C ratio and risk of diabetes, with their mediating effect being 93.1% and 22.0%, respectively.	Creatinine	125-135	cystatin C	Homo sapiens	139-149
35277788-6	2022	Positive correlations were found between IL-1beta and fasting blood sugar and between creatinine levels and IL-17, HbA1c%, and sodium levels.	Creatinine	86-96	hemoglobin subunit alpha 1	Homo sapiens	115-119
35478277-0	2022	Creatinine-cystatin C ratio and mortality in cancer patients: a retrospective cohort study.	Creatinine	0-10	cystatin C	Homo sapiens	11-21
35478277-2	2022	Recent studies have suggested that the creatinine-cystatin C ratio may correlate with muscle mass in several patient populations.	Creatinine	39-49	cystatin C	Homo sapiens	50-60
35478277-3	2022	The association between creatinine-cystatin C ratio and survival was assessed in cancer patients.	Creatinine	24-34	cystatin C	Homo sapiens	35-45
35478277-9	2022	In the Cox proportional hazards analysis, an increase in the creatinine-cystatin C ratio was associated with a significant decrease in the 6-month mortality (per 1 creatinine-cystatin C ratio, hazard ratio (HR) 0.35; 95% confidence interval (CI), 0.28-0.44).	Creatinine	61-71	cystatin C	Homo sapiens	72-82
35478277-9	2022	In the Cox proportional hazards analysis, an increase in the creatinine-cystatin C ratio was associated with a significant decrease in the 6-month mortality (per 1 creatinine-cystatin C ratio, hazard ratio (HR) 0.35; 95% confidence interval (CI), 0.28-0.44).	Creatinine	61-71	cystatin C	Homo sapiens	175-185
35478277-9	2022	In the Cox proportional hazards analysis, an increase in the creatinine-cystatin C ratio was associated with a significant decrease in the 6-month mortality (per 1 creatinine-cystatin C ratio, hazard ratio (HR) 0.35; 95% confidence interval (CI), 0.28-0.44).	Creatinine	164-174	cystatin C	Homo sapiens	72-82
35478277-9	2022	In the Cox proportional hazards analysis, an increase in the creatinine-cystatin C ratio was associated with a significant decrease in the 6-month mortality (per 1 creatinine-cystatin C ratio, hazard ratio (HR) 0.35; 95% confidence interval (CI), 0.28-0.44).	Creatinine	164-174	cystatin C	Homo sapiens	175-185
35478277-14	2022	CONCLUSIONS: The creatinine-cystatin C ratio at the time of cancer diagnosis significantly associates with survival and hospitalization in cancer patients.	Creatinine	17-27	cystatin C	Homo sapiens	28-38
35422619-1	2022	Purpose: This study explored the value of the serum creatinine/cystatin C (Cr/CysC) ratio in diagnosing the reduction of muscle strength in men with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).	Creatinine	75-77	cystatin C	Homo sapiens	63-73
35422619-9	2022	The Cr/CysC ratio was correlated with handgrip strength, FEV1, FVC, FEV1%pred, BMI and weight.	Creatinine	4-6	cystatin C	Homo sapiens	7-11
35422619-10	2022	The area under curve for low handgrip strength was greater for the Cr/CysC ratio than for Cr.	Creatinine	67-69	cystatin C	Homo sapiens	70-74
35422619-12	2022	Conclusion: The Cr/CysC ratio is a useful predictor of muscle strength decline in male AECOPD patients, while a low Cr/CysC ratio is a risk factor for muscle strength decline in male patients with AECOPD.	Creatinine	116-118	cystatin C	Homo sapiens	119-123
34709533-5	2022	Lp(a) was also positively correlated with interleukin (IL)-8 (r = 0.308; p = 0.037), fibrinogen (r = 0.344; p = 0.032) and creatinine (r = 0.327; p = 0.027), and negatively correlated with ADAMTS13 activity/VWF:Ag (r = - 0.335; p = 0.021); but not with IL-6 (r = 0.241; p = 0.106).	Creatinine	123-133	lipoprotein(a)	Homo sapiens	0-5
35298547-2	2022	Some patients with IC experience a rise in Urinary N-acetyl-beta-D-Glucosaminidase (NAG)/ Creatinine (Cr) ratio, a marker of renal injury, following exercise.	Creatinine	102-104	O-GlcNAcase	Homo sapiens	51-82
35220701-13	2022	The AUC quality of cystatin C was significantly better than that of creatinine (z=2.34, P<0.05), the AUC quality and sensitivity and specificity under the optimal threshold of HDL-C were all significantly better than those of cystatin C (z=3.33, with chi2 values of 6.43 and 7.87, respectively, P<0.01) and creatinine (z=5.34, with chi2 values of 6.32 and 6.41, respectively, P<0.01); the AUC quality and sensitivity and specificity under the optimal threshold of the joint prediction model were all significantly better than those of creatinine, cystatin C, and HDL-C (with z values of 6.18, 4.50, and 2.06, respectively, chi2 values of 5.31, 7.23, 3.99, 6.56, 7.34, and 4.00, respectively, P<0.05 or P<0.01).	Creatinine	307-317	cystatin C	Homo sapiens	19-29
35220701-13	2022	The AUC quality of cystatin C was significantly better than that of creatinine (z=2.34, P<0.05), the AUC quality and sensitivity and specificity under the optimal threshold of HDL-C were all significantly better than those of cystatin C (z=3.33, with chi2 values of 6.43 and 7.87, respectively, P<0.01) and creatinine (z=5.34, with chi2 values of 6.32 and 6.41, respectively, P<0.01); the AUC quality and sensitivity and specificity under the optimal threshold of the joint prediction model were all significantly better than those of creatinine, cystatin C, and HDL-C (with z values of 6.18, 4.50, and 2.06, respectively, chi2 values of 5.31, 7.23, 3.99, 6.56, 7.34, and 4.00, respectively, P<0.05 or P<0.01).	Creatinine	535-545	cystatin C	Homo sapiens	19-29
35250809-10	2022	We identified six metabolites that were significantly altered in serum of patients with SMAJ in comparison to controls: increased creatine and pyruvate, and decreased creatinine, taurine, N-acetyl-carnosine, and succinate.	Creatinine	167-177	SMAJ	Homo sapiens	88-92
35207297-12	2022	The predictive capacity of Cystatin C was superior to serum creatinine (p = 0.0211) (4) Conclusion: Cystatin C represents a very sensitive and specific biomarker to predict AKI in patients undergoing thoracic surgery with MHCA even before surgery, whereas the predictive capacity of (TIMP-2)*(IGFBP7) is only moderate and inferior to that of serum creatinine.	Creatinine	60-70	cystatin C	Homo sapiens	100-110
35207297-12	2022	The predictive capacity of Cystatin C was superior to serum creatinine (p = 0.0211) (4) Conclusion: Cystatin C represents a very sensitive and specific biomarker to predict AKI in patients undergoing thoracic surgery with MHCA even before surgery, whereas the predictive capacity of (TIMP-2)*(IGFBP7) is only moderate and inferior to that of serum creatinine.	Creatinine	348-358	cystatin C	Homo sapiens	100-110
34978023-9	2022	In addition, when compared to the relatively weak CD133 staining in the proximal tubules of the FSGS group, the proximal tubules of the collapsing glomerulopathy group all showed diffuse and strong CD133 staining as a feature of severe acute tubular injury, which corresponded to the high serum creatinine levels in these patients.	Creatinine	295-305	prominin 1	Homo sapiens	198-203
2532405-5	1989	In our experience the urinary ratio of NAG (N-acetyl-glucosaminidase) to creatinine, a good marker of renal tubular damage, increased after treatment with both the original and the modified spark gap Dornier HM3 lithotripters and with the piezoelectric Wolf Piezolith 2200.	Creatinine	73-83	cholinergic receptor muscarinic 3	Homo sapiens	208-211
2770278-7	1989	Twenty-four hours after injury, BUN, creatinine, and fractional sodium excretion values were less in FDP-treated rats than in control rats (P less than 0.001, P less than 0.005, and P less than 0.001, respectively) and not different from values observed in sham-operated rats.	Creatinine	37-47	fructose-bisphosphatase 1	Rattus norvegicus	101-104
2474402-5	1989	The least-squares estimate of 1.67 for the NAPA renal clearance/creatinine clearance ratio was similar to the value of 1.68 previously reported for functionally anephric patients and showed the expected age-associated decrease.	Creatinine	64-74	NSF attachment protein alpha	Homo sapiens	43-47
2528561-3	1989	Urinary NAG excretion was significantly higher in diabetic patients with and without persistent proteinuria (1.16 +/- 0.09 and 3.19 +/- 1.2 Umol/L creatinine, respectively) compared to controls (0.37 +/- 0.03 Umol/L creatinine p less than 0.01).	Creatinine	147-157	O-GlcNAcase	Homo sapiens	8-11
2528561-3	1989	Urinary NAG excretion was significantly higher in diabetic patients with and without persistent proteinuria (1.16 +/- 0.09 and 3.19 +/- 1.2 Umol/L creatinine, respectively) compared to controls (0.37 +/- 0.03 Umol/L creatinine p less than 0.01).	Creatinine	216-226	O-GlcNAcase	Homo sapiens	8-11
3241258-8	1988	Urinary calcium (creatinine) was negatively correlated with SBP in males, and with SBP and DBP in the south.	Creatinine	17-27	selenium binding protein 1	Homo sapiens	60-63
3241258-8	1988	Urinary calcium (creatinine) was negatively correlated with SBP in males, and with SBP and DBP in the south.	Creatinine	17-27	selenium binding protein 1	Homo sapiens	83-86
3205883-12	1988	The serum creatinine frequently but not always changed in parallel with the NAG values.	Creatinine	10-20	O-GlcNAcase	Rattus norvegicus	76-79
3234588-2	1988	Urinary NAG activity was determined using a chromogenic substrate, 2 methoxy-4-(2"-nitrovinyl)-phenyl 2-acetamido-3-deoxy-beta-D-glucopyranoside, and expressed as mumol MNP released/hour/mmol of creatinine.	Creatinine	195-205	O-GlcNAcase	Homo sapiens	8-11
3362841-5	1988	An inverse linear correlation was noticed between creatinine clearance and serum trypsinogen 1 levels.	Creatinine	50-60	serine protease 1	Homo sapiens	81-94
2447826-6	1987	In a group of 39 persons with multiple sclerosis, 48 with other neurological diseases, and 26 normal control subjects, the concentration of urinary MBP-like material, related to the concentration of urinary creatinine, was significantly higher in the multiple sclerosis group (22.0 ng MBP-like material/mg creatinine) than in the other neurological diseases or control groups, in which the values were 7.0 and 3.9 ng MBP-like material/mg creatinine, respectively.	Creatinine	207-217	myelin basic protein	Homo sapiens	148-151
2447826-6	1987	In a group of 39 persons with multiple sclerosis, 48 with other neurological diseases, and 26 normal control subjects, the concentration of urinary MBP-like material, related to the concentration of urinary creatinine, was significantly higher in the multiple sclerosis group (22.0 ng MBP-like material/mg creatinine) than in the other neurological diseases or control groups, in which the values were 7.0 and 3.9 ng MBP-like material/mg creatinine, respectively.	Creatinine	306-316	myelin basic protein	Homo sapiens	148-151
2447826-6	1987	In a group of 39 persons with multiple sclerosis, 48 with other neurological diseases, and 26 normal control subjects, the concentration of urinary MBP-like material, related to the concentration of urinary creatinine, was significantly higher in the multiple sclerosis group (22.0 ng MBP-like material/mg creatinine) than in the other neurological diseases or control groups, in which the values were 7.0 and 3.9 ng MBP-like material/mg creatinine, respectively.	Creatinine	306-316	myelin basic protein	Homo sapiens	148-151
3445866-3	1987	Urinary NAG level was 2.59 +/- 1.44 U/l, 1.93 +/- 0.80 U/g creatinine in males and 2.67 +/- 1.15 U/l, 2.08 +/- 0.78 U/g creatinine in females, and there was no significant sex difference.	Creatinine	59-69	O-GlcNAcase	Homo sapiens	8-11
3445866-3	1987	Urinary NAG level was 2.59 +/- 1.44 U/l, 1.93 +/- 0.80 U/g creatinine in males and 2.67 +/- 1.15 U/l, 2.08 +/- 0.78 U/g creatinine in females, and there was no significant sex difference.	Creatinine	120-130	O-GlcNAcase	Homo sapiens	8-11
2890451-4	1987	N-Acetyl-beta-D-glucosaminidase was more sensitive to detect renal dysfunction than the other enzymes and the conventional parameters serum creatinine, total protein excretion, and the measurement of glomerular filtration rate.	Creatinine	140-150	O-GlcNAcase	Homo sapiens	0-31
2890304-3	1987	The median urinary concentrations of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase in women without preeclampsia increased progressively through the first, second, and third trimesters and reached maximum values of 1.12 and 0.77 U/mmol creatinine, respectively.	Creatinine	249-259	O-GlcNAcase	Homo sapiens	37-68
3038377-7	1987	In addition, results for serum and urinary hCG correlated well when the latter was expressed in terms of creatinine excretion.	Creatinine	105-115	hypertrichosis 2 (generalised, congenital)	Homo sapiens	43-46
3153328-5	1987	In Case 2, PH I was diagnosed early because of the finding of increased renal echogenicity at 3 weeks of age; this patient had numerous episodes of stone formation despite continuous treatment with pyridoxine, but maintained renal function with normal serum creatinine levels at the age of 28 months.	Creatinine	258-268	glucose-6-phosphate isomerase	Homo sapiens	11-15
2426021-2	1986	IgA nephritis patients with high serum creatinine value (Scr) showed markedly elevated levels of CR1, whereas patients with normal Scr had normal CR1 levels.	Creatinine	39-49	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	97-100
3764409-2	1986	Urinary NAG activity increased with increasing beta 2-m concentration up to about 100 U/g creatinine; above this value the NAG activity did not increase with increasing beta 2-m concentration.	Creatinine	90-100	O-GlcNAcase	Homo sapiens	8-11
3516481-6	1986	A positive correlation was seen between HbA1 and plasma glucose concentrations in all subjects, and between HbA1 and serum urea and creatinine concentrations in the non-diabetic subjects.	Creatinine	132-142	hemoglobin subunit alpha 1	Homo sapiens	108-112
2868815-4	1986	By relating the enzyme excretion to urinary creatinine we could reduce the variability of brush-border enzyme output and could completely compensate for the effect of diuresis on the excretion of N-acetyl-beta-D-glucosaminidase.	Creatinine	44-54	O-GlcNAcase	Homo sapiens	196-227
2409989-8	1985	Nevertheless their plasma levels of beta-thromboglobulin were elevated (76 micrograms/l) and correlated with the serum creatinine values.	Creatinine	119-129	pro-platelet basic protein	Homo sapiens	36-56
4035675-8	1985	Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity (nmol/hr/mg creatinine) was significantly elevated in both groups by 48 hr, and further increased by 72 hr.	Creatinine	67-77	O-GlcNAcase	Rattus norvegicus	8-39
4035675-8	1985	Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity (nmol/hr/mg creatinine) was significantly elevated in both groups by 48 hr, and further increased by 72 hr.	Creatinine	67-77	O-GlcNAcase	Rattus norvegicus	41-44
6085600-2	1984	Urinary excretion of EDC1 (mg/g creatinine) may be classified in four ranges: i) low (less than 15); ii) light (15-30); iii) intermediate (31-45); and iv) heavy (greater than 45).	Creatinine	32-42	alpha-1-microglobulin/bikunin precursor	Homo sapiens	21-25
6085600-4	1984	Patients with a variety of non-malignant disorders excreted 14.6 +/- 4 mg EDC1/g creatinine, but patients with renal failure, rheumatoid arthritis, and infectious diseases averaged 130.3 +/- 60.	Creatinine	81-91	alpha-1-microglobulin/bikunin precursor	Homo sapiens	74-78
6670088-1	1983	In 81 children without any urinary or kidney disease and in children with various diseases of the urinary tract, the excretion of N-acetyl-beta-D-glucosaminidase (NAG) was measured in an urine sample and related to creatinine excretion.	Creatinine	215-225	O-GlcNAcase	Homo sapiens	130-161
6670088-1	1983	In 81 children without any urinary or kidney disease and in children with various diseases of the urinary tract, the excretion of N-acetyl-beta-D-glucosaminidase (NAG) was measured in an urine sample and related to creatinine excretion.	Creatinine	215-225	O-GlcNAcase	Homo sapiens	163-166
7214750-5	1981	The excretion of Nag per g creatinine differed significantly between the various histologic subgroups of glomerulonephritis but not between groups with various degrees of tubulointerstitial changes.	Creatinine	27-37	O-GlcNAcase	Homo sapiens	17-20
6783554-0	1981	Creatinine production rate measured by whole body counting of 40K.	Creatinine	0-10	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	62-65
6795517-3	1981	A striking relationship between some F VIII activities and serum creatinine was detectable in patients with glomerulonephritis and kidney transplants, with mild or moderate renal insufficiency.	Creatinine	65-75	coagulation factor VIII	Homo sapiens	37-43
6163046-3	1980	beta-Thromboglobulin correlated positively with serum creatinine and the highest values were encountered in patients with abnormal creatinine concentration.	Creatinine	54-64	pro-platelet basic protein	Homo sapiens	0-20
6163046-3	1980	beta-Thromboglobulin correlated positively with serum creatinine and the highest values were encountered in patients with abnormal creatinine concentration.	Creatinine	131-141	pro-platelet basic protein	Homo sapiens	0-20
364392-1	1978	Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was shown to be reproducible in random urine specimens when expressed as the ratio of NAG to milligrams of urinary creatinine.	Creatinine	174-184	O-GlcNAcase	Homo sapiens	21-52
364392-1	1978	Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was shown to be reproducible in random urine specimens when expressed as the ratio of NAG to milligrams of urinary creatinine.	Creatinine	174-184	O-GlcNAcase	Homo sapiens	54-57
322922-6	1977	The mean NAPA elimination half-life of 10.9 hr was longer than the 6.2 hr half-life reported for normal subjects, but its prolongation was predictably correlated with reductions in creatinine clearance.	Creatinine	181-191	NSF attachment protein alpha	Homo sapiens	9-13
1236567-4	1975	Measurement of the 5-HIAA: creatinine ratio in 8-hour urine collections is therefore proposed as an aid in the diagnosis of coeliac disease.	Creatinine	27-37	activation induced cytidine deaminase	Homo sapiens	100-103
1156788-2	1975	The variation in NAG activity due to changing rates of urine flow was almost eliminated by factoring enzyme activity by the urinary creatinine concentration.	Creatinine	132-142	O-GlcNAcase	Homo sapiens	17-20
124861-0	1975	[Effect of inorganic phosphates, urea and creatinine on ATPase activity in erythrocyte shadows obtained from healthy subjects and uremic patients].	Creatinine	42-52	dynein axonemal heavy chain 8	Homo sapiens	56-62
1149366-4	1975	This variability is a major limiting factor in the use of dosage regimen nomograms that assume a constant V-ss-D and a rigorous relationship between t1/2beta and creatinine clearance (Cl-CR).	Creatinine	162-172	interleukin 1 receptor like 1	Homo sapiens	149-157
34023578-12	2021	Model 1 (Hemorrhage alone): Cr increased from a baseline of 1.2 to 3.0 in NS control animals (P < 0.0001) 8 h after hemorrhage, whereas it rose only to 2.1 in VPA treated animals (P = 0.004).	Creatinine	28-30	serine peptidase inhibitor Kazal type 5	Homo sapiens	74-76
34023578-13	2021	Model 2 (Polytrauma): Cr levels increased from baseline of 1.3 to 2.5 mg/dL (P = 0.01) in NS control animals 4 h after injury but rose to only 1.8 in VPA treated animals (P = 0.02).	Creatinine	22-24	serine peptidase inhibitor Kazal type 5	Homo sapiens	90-92
34009708-1	2021	AIMS: The glucagon-like peptide-1 receptor agonists (GLP-1 RAs) liraglutide and semaglutide appeared to reduce kidney outcomes (composite of macroalbuminuria, doubling of serum creatinine, renal-replacement therapy, or renal death) in patients with type 2 diabetes in the LEADER and SUSTAIN 6 trials, primarily driven by changes in albuminuria.	Creatinine	177-187	glucagon like peptide 1 receptor	Homo sapiens	10-42
34009708-1	2021	AIMS: The glucagon-like peptide-1 receptor agonists (GLP-1 RAs) liraglutide and semaglutide appeared to reduce kidney outcomes (composite of macroalbuminuria, doubling of serum creatinine, renal-replacement therapy, or renal death) in patients with type 2 diabetes in the LEADER and SUSTAIN 6 trials, primarily driven by changes in albuminuria.	Creatinine	177-187	glucagon like peptide 1 receptor	Homo sapiens	53-58
33988814-5	2021	The results showed that serum amylase, lipase, urea, and creatinine levels of p38 inhibitor of T groups were markedly lower than the ANP groups.	Creatinine	57-67	mitogen activated protein kinase 14	Rattus norvegicus	78-81
34054830-8	2021	IL-26 levels correlated with SLEDAI score and the urine protein to creatinine ratio (uPCR) (p < 0.001).	Creatinine	67-77	interleukin 26	Homo sapiens	0-5
33978827-11	2021	eGFR calculated by serum cystatin C-based formulas was more reliable than that calculated by creatinine-based equations.Conclusion: Serum cystatin C is the best biomarker for diagnosis of AKI in pediatric cirrhotics, especially with decompensation and SBP.	Creatinine	93-103	cystatin C	Homo sapiens	138-148
33744039-5	2021	Plasma FAs (% total FAs) in cholesteryl esters were assessed at baseline (2002-2006), and ~40 months change in creatinine-cystatin C based glomerular filtration rate was estimated (eGFR, in ml/min per 1.73 m2).	Creatinine	111-121	cystatin C	Homo sapiens	122-132
33795382-9	2022	In each creatinine-based GFR category, 17%, 19% and 31% reclassified to a lower GFR category by cystatin C.	Creatinine	8-18	cystatin C	Homo sapiens	96-106
33795382-12	2022	CONCLUSIONS: A single cystatin C at admission to the intensive care unit added significant predictive value to creatinine for long-term cardiovascular death risk assessment.	Creatinine	111-121	cystatin C	Homo sapiens	22-32
33157151-1	2021	The CKD-EPI creatinine-based estimation equation for glomerular filtration rate (GFR) cannot be used in children, overestimates GFR in young adults, and its combination with the KDIGO recommended pediatric CKiD (Schwartz bedside) equation causes implausible increases in estimated GFR when switching from pediatric to adult care.	Creatinine	12-22	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	81-84
33157151-5	2021	CKD-EPI with age-adjusted creatinine instead of actual age and creatinine led to extensive improvements in bias, precision, and accuracy at all ages, in both sexes and at all levels of mGFR.	Creatinine	26-36	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	185-189
33157151-5	2021	CKD-EPI with age-adjusted creatinine instead of actual age and creatinine led to extensive improvements in bias, precision, and accuracy at all ages, in both sexes and at all levels of mGFR.	Creatinine	63-73	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	185-189
33200398-5	2021	We used 3- and 11-month-old transgenic mice with overexpression of PGC-1alpha under the control of muscle creatinine kinase promoter (MCK-PGC-1alpha), which have a constitutively developed endurance muscle phenotype.	Creatinine	106-116	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	67-77
33828483-9	2021	The survival curves of patients with elevated cystatin C/creatinine levels show a sharper decline than those of patients with normal cystatin C/creatinine levels (p < 0.001).	Creatinine	57-67	cystatin C	Homo sapiens	46-56
33828483-9	2021	The survival curves of patients with elevated cystatin C/creatinine levels show a sharper decline than those of patients with normal cystatin C/creatinine levels (p < 0.001).	Creatinine	144-154	cystatin C	Homo sapiens	46-56
33828483-11	2021	Conclusions: Elevated cystatin C, which occurs earlier than serum creatinine, is useful for the early detection of renal function abnormality and might have better predictive value for disease severity in COVID-19 patients, while elevated serum creatinine may have a better predictive value for risks of death.	Creatinine	66-76	cystatin C	Homo sapiens	22-32
33828483-11	2021	Conclusions: Elevated cystatin C, which occurs earlier than serum creatinine, is useful for the early detection of renal function abnormality and might have better predictive value for disease severity in COVID-19 patients, while elevated serum creatinine may have a better predictive value for risks of death.	Creatinine	245-255	cystatin C	Homo sapiens	22-32
33737450-0	2021	Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis.	Creatinine	54-64	titin	Homo sapiens	28-33
33737450-4	2021	We used urinary creatinine (Cr) levels to normalise the urinary levels of titin fragment.	Creatinine	16-26	titin	Homo sapiens	74-79
33737450-4	2021	We used urinary creatinine (Cr) levels to normalise the urinary levels of titin fragment.	Creatinine	28-30	titin	Homo sapiens	74-79
33737450-5	2021	RESULTS: Compared with HC, patients with ALS had significantly increased urinary levels of titin N-terminal fragment normalised with Cr (titin/Cr) (ALS, 27.2 pmol/mg/dL; HC, 5.8 pmol/mg/dL; p<0.001), which were correlated with the scores of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (r=-0.422, p<0.001).	Creatinine	133-135	titin	Homo sapiens	91-96
33737450-5	2021	RESULTS: Compared with HC, patients with ALS had significantly increased urinary levels of titin N-terminal fragment normalised with Cr (titin/Cr) (ALS, 27.2 pmol/mg/dL; HC, 5.8 pmol/mg/dL; p<0.001), which were correlated with the scores of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (r=-0.422, p<0.001).	Creatinine	133-135	titin	Homo sapiens	137-142
33737450-5	2021	RESULTS: Compared with HC, patients with ALS had significantly increased urinary levels of titin N-terminal fragment normalised with Cr (titin/Cr) (ALS, 27.2 pmol/mg/dL; HC, 5.8 pmol/mg/dL; p<0.001), which were correlated with the scores of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (r=-0.422, p<0.001).	Creatinine	143-145	titin	Homo sapiens	91-96
33737450-6	2021	A Cox proportional hazards model demonstrated that the high urinary level of titin/Cr was a survival predictor in patients with ALS.	Creatinine	83-85	titin	Homo sapiens	77-82
33737450-7	2021	Multivariate analysis of prognostic factors showed that the urinary titin/Cr and serum NfL were independent factors for poor prognosis.	Creatinine	74-76	titin	Homo sapiens	68-73
33738645-6	2022	The symptomatology at admission was more severe among patients requiring hemodialysis: a lower mean value for initial pH, lower initial alkaline reserve (AR) and higher mean values for initial serum creatinine (Cr1).	Creatinine	199-209	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	211-214
33726550-10	2022	A negative correlation between the peripheral frequency of CD14+CCR5+ and the creatinine levels was identified in the intradialytic exercise session.	Creatinine	78-88	CD14 molecule	Homo sapiens	59-63
33691659-6	2021	Circulating BNP levels correlated significantly and positively with neutrophil to lymphocyte ratio, systolic blood pressure, urinary albumin-to-creatinine ratio, and prevalence of hypertension, peripheral arterial disease, diabetic retinopathy, peripheral neuropathy, and nephropathy, and negatively with triglyceride, fasting blood glucose, lymphocyte count, hemoglobin, estimated glomerular filtration rate, bilirubin, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites and corresponding T scores (P < 0.01 or P < 0.05).	Creatinine	144-154	natriuretic peptide B	Homo sapiens	12-15
33346727-11	2021	Additionally, urinary DPP4 activity correlated positively with serum creatinine levels, proteinuria, and blood pressure.	Creatinine	69-79	dipeptidylpeptidase 4	Rattus norvegicus	22-26
33314296-6	2021	Moreover, lncRNA HULC was positively associated with TNF-alpha, IL-6, IL-17, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, serum creatinine, white blood cell, and C-reactive protein in sepsis patients, but not in controls.	Creatinine	153-163	hepatocellular carcinoma up-regulated long non-coding RNA	Homo sapiens	17-21
32066882-4	2021	This study analysed creatinine-adjusted urinary PAH metabolite concentrations and questionnaire data from ~1200 individuals aged 16 years and older surveyed in Cycle 2 of the Canadian Health Measures Survey (CHMS).	Creatinine	20-30	phenylalanine hydroxylase	Homo sapiens	48-51
33727514-5	2021	Results: In the three assessed periods, the mean (standard deviation) cystatin C level was 1.72 (0.57), 1.59 (0.64), and 1.82 (0.82), respectively, being highest after 5 years of transplantation, normal in 9.40%, and elevated in 90.60% of the participants, while creatinine level, decreased from 1.57 (0.53) to 1.52 (0.64) in 1-5 years, then it became the highest at 1.75 (0.69) in more than 5 years.	Creatinine	263-273	cystatin C	Homo sapiens	70-80
33074222-8	2021	Increased DVB could be associated with elevated SBV, hematocrit level, and blood urea nitrogen/creatinine ratio (p = <0.001, 0.004, and 0.002, respectively).	Creatinine	95-105	major histocompatibility complex, class II, DQ beta 3	Homo sapiens	10-13
33044321-4	2021	Multivariable regression models were used to examine associations between creatinine and cystatin C based estimates of glomerular filtration rate (eGFR), albumin-creatinine ratio (ACR) and echocardiographic measures of cardiac structure and function.	Creatinine	74-84	cystatin C	Homo sapiens	89-99
32750487-1	2021	BACKGROUND: Estimated glomerular filtration rate (GFR) from cystatin C (eGFRcys) is often considered a more accurate method to assess GFR compared to estimated GFR from creatinine (eGFRcr) in the setting of heart failure (HF) and sarcopenia because cystatin C is hypothesized to be less affected by muscle mass than creatinine.	Creatinine	316-326	cystatin C	Homo sapiens	60-70
33270240-3	2021	In vivo experiments in female Wistar rats demonstrated that alterations in urea, creatinine, and uric acid levels promoted (p < .05) by ketoprofen were reversed when AEG was co-administered.	Creatinine	81-91	cysteine-rich secretory protein 3	Rattus norvegicus	166-169
32739656-3	2021	Although bioelectrical impedance analysis (BIA) is widely used, its accuracy is questioned; plasma creatinine-to-cystatin C (CC) ratio could be an attractive alternative.	Creatinine	99-109	cystatin C	Homo sapiens	113-123
33642514-2	2021	The pharmacist initially carried out therapeutic drug monitoring using an estimate of the creatinine clearance (CLcr) level, which was based on the serum creatinine (SCr) and serum cystatin-C (CysC) levels, but was ultimately unable to control the plasma VCM concentration.	Creatinine	90-100	cystatin C	Homo sapiens	181-191
33642514-2	2021	The pharmacist initially carried out therapeutic drug monitoring using an estimate of the creatinine clearance (CLcr) level, which was based on the serum creatinine (SCr) and serum cystatin-C (CysC) levels, but was ultimately unable to control the plasma VCM concentration.	Creatinine	90-100	cystatin C	Homo sapiens	193-197
32927397-3	2020	Results of a multiple linear regression (controlling for depression, serum creatinine level, age, BMI, total brain volume, MoCA score, sex, ethnicity, smoking status, history of diabetes) showed that Gal3 levels significantly predicted left (p = .027) but not right hippocampal volume.	Creatinine	75-85	galectin 3	Homo sapiens	200-204
33269066-8	2020	The ER antagonists group showed a significantly greater reduction in albuminuria and more patients with 40% reduction in urinary albumin-to-creatinine ratio than the control group (P < 0.0001 and P = 0.02, respectively).	Creatinine	140-150	epiregulin	Homo sapiens	4-6
33313259-7	2020	Serum CysC elevation was an independent predictor of LVH after correction for endogenous creatinine clearance rate (eCCr), left ventricular ejection fraction (LVEF), and NT-proBNP.	Creatinine	89-99	cystatin C	Homo sapiens	6-10
33144465-2	2020	This prospective pharmacokinetic study evaluated cytidine deaminase (CDA) activity, the second drug-metabolizing enzyme that generates 5"-deoxy-5-fluorouridine (5"-DFUR) from 5"-deoxy-5-fluorocytidine (5"-DFCR), as well as creatinine clearance (CLcr).	Creatinine	223-233	cytidine deaminase	Homo sapiens	49-67
33144465-2	2020	This prospective pharmacokinetic study evaluated cytidine deaminase (CDA) activity, the second drug-metabolizing enzyme that generates 5"-deoxy-5-fluorouridine (5"-DFUR) from 5"-deoxy-5-fluorocytidine (5"-DFCR), as well as creatinine clearance (CLcr).	Creatinine	223-233	cytidine deaminase	Homo sapiens	69-72
32715474-8	2020	Finally, both ADAM10 and NOTCH2 expression were positively correlated with the degree of renal interstitial fibrosis in IgA nephropathy patients, and increased ADAM10 expression was negatively correlated with decreased kidney function evaluated by serum creatinine, Cystatin C and estimated glomerular filtration rate.	Creatinine	254-264	ADAM metallopeptidase domain 10	Homo sapiens	160-166
33120841-10	2020	CONCLUSION: Careful monitoring of renal function especially serum creatinine should be emphasized during DAC treatment.	Creatinine	66-76	arylacetamide deacetylase	Homo sapiens	105-108
33096837-0	2020	Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.	Creatinine	76-86	RAB38, member RAS oncogene family	Homo sapiens	46-51
33096837-2	2020	Previous findings from a meta-analysis of GWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations.	Creatinine	139-149	RAB38, member RAS oncogene family	Homo sapiens	79-84
33096837-2	2020	Previous findings from a meta-analysis of GWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations.	Creatinine	139-149	cathepsin C	Homo sapiens	85-89
33096837-6	2020	Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients.	Creatinine	124-134	RAB38, member RAS oncogene family	Homo sapiens	64-69
33224650-6	2020	A significantly positive relationship was found between serum cystatin C levels and creatinine and high-sensitivity C-reactive protein (hs-CRP) levels in both groups (r-value = 0.288, p-value = 0.005, r-value = 0.143, p-value = 0.007, respectively).	Creatinine	84-94	cystatin C	Homo sapiens	62-72
33110921-6	2020	Circulating levels of BNP were significantly and positively associated with systolic blood pressure (P = 0.035), neutrophil-to-lymphocyte ratio (P = 0.007), creatinine (P = 0.030), vibration perception threshold values (P = 0.021), and the prevalence of diabetic foot ulceration (P = 0.039), peripheral arterial disease (P = 0.013), DPN (P = 0.032), and diabetic nephropathy (P = 0.020) and negatively with lymphocyte count (P = 0.003) and ankle-brachial index (P = 0.038), irrespective of age, sex, and body mass index.	Creatinine	157-167	natriuretic peptide B	Homo sapiens	22-25
32791815-9	2020	The two patients who returned to dialysis were diagnosed of IgAN by transplant renal biopsy because of elevated creatinine, proteinuria and hematuria, 9 years and 4 years after kidney transplant respectively.	Creatinine	112-122	IGAN1	Homo sapiens	60-64
32710733-11	2020	The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage.	Creatinine	197-207	Janus kinase 2	Homo sapiens	45-49
32213726-0	2020	Creatinine/(cystatin C x body weight) ratio is associated with skeletal muscle mass index.	Creatinine	0-10	cystatin C	Homo sapiens	12-22
32213726-1	2020	We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI).	Creatinine	37-47	cystatin C	Homo sapiens	57-67
32213726-1	2020	We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI).	Creatinine	37-47	cystatin C	Homo sapiens	69-73
32213726-1	2020	We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI).	Creatinine	49-52	cystatin C	Homo sapiens	57-67
32213726-1	2020	We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI).	Creatinine	49-52	cystatin C	Homo sapiens	69-73
32213726-3	2020	Thus, we hypothesized that the creatinine to (cystatin C x body weight [BW]) relationship (Cre/[CysC x BW]) might be associated with weight-adjusted SMI.	Creatinine	31-41	cystatin C	Homo sapiens	46-56
32213726-3	2020	Thus, we hypothesized that the creatinine to (cystatin C x body weight [BW]) relationship (Cre/[CysC x BW]) might be associated with weight-adjusted SMI.	Creatinine	31-41	cystatin C	Homo sapiens	96-100
32699192-4	2020	The intensities of both intrarenal TLR7 and CD19 proteins were closely associated with kidney function (estimated glomerular filtration rate [eGFR] and serum creatinine concentration) and renal histopathology (tubular atrophy, leukocyte infiltration, tubulointerstitial fibrosis, and global glomerulosclerosis) in patients with IgAN.	Creatinine	158-168	CD19 molecule	Homo sapiens	44-48
8036046-3	1994	Median NAG concentrations were 114.2 mumol/hour/mg creatinine (CR) (range, 5.7 to 305.4) in 17 febrile UTI patients vs. 13.8 (range, 3.4 to 104.3) in 17 age and sex-matched febrile controls with negative urine cultures, P = 0.0001.	Creatinine	51-61	O-GlcNAcase	Homo sapiens	7-10
8036046-3	1994	Median NAG concentrations were 114.2 mumol/hour/mg creatinine (CR) (range, 5.7 to 305.4) in 17 febrile UTI patients vs. 13.8 (range, 3.4 to 104.3) in 17 age and sex-matched febrile controls with negative urine cultures, P = 0.0001.	Creatinine	63-65	O-GlcNAcase	Homo sapiens	7-10
8036046-4	1994	The sensitivity and specificity of NAG &gt; or = 40 mumol/hour/mg of CR in predicting UTI in febrile patients, regardless of the site of infection, were 88 and 88%, respectively.	Creatinine	69-71	O-GlcNAcase	Homo sapiens	35-38
8154076-8	1994	The NAG levels standardized to urine creatinine revealed a mean value among refluxers of 15.514 mumol/g creatinine.	Creatinine	104-114	O-GlcNAcase	Homo sapiens	4-7
8302419-2	1993	Urinary kininogen underwent a transient increase with a maximum on day 7 (78 +/- 22 versus 4.2 +/- 1.6 ng bradykinin/mg creatinine) whereas plasma kininogen did not and glomerular filtration rate decreased (92 +/- 8 versus 895 +/- 70 microliters/min).	Creatinine	120-130	kininogen 2-like 1	Rattus norvegicus	8-17
8413786-13	1993	According to the Cox model other independent variables significantly associated with increase in the probability of death while on CAPD were advancing age, low serum creatinine concentrations and elevated serum cholesterol levels.	Creatinine	166-176	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
1443171-8	1992	Serum creatinine levels were significantly higher in GT-treated animals infused with EGF or saline and killed at days 9 and 12 compared with saline-treated animals infused with EGF or saline alone (P &lt; 0.01).	Creatinine	6-16	epidermal growth factor like 1	Rattus norvegicus	85-88
1424118-2	1992	Serum Lp(a) concentrations were significantly increased in subjects with obvious renal dysfunction (serum creatinine &gt; or = 176.8 mumol/L) compared with normal control subjects.	Creatinine	106-116	lipoprotein(a)	Homo sapiens	6-11
1424118-3	1992	Urinary Lp(a) excretion was decreased in subjects with obvious renal dysfunction compared with subjects without obvious renal dysfunction (serum creatinine &lt; or = 88.4 mumol/L) and was negatively and positively correlated with serum creatinine and creatinine clearance, respectively.	Creatinine	145-155	lipoprotein(a)	Homo sapiens	8-13
1424118-3	1992	Urinary Lp(a) excretion was decreased in subjects with obvious renal dysfunction compared with subjects without obvious renal dysfunction (serum creatinine &lt; or = 88.4 mumol/L) and was negatively and positively correlated with serum creatinine and creatinine clearance, respectively.	Creatinine	236-246	lipoprotein(a)	Homo sapiens	8-13
1424118-3	1992	Urinary Lp(a) excretion was decreased in subjects with obvious renal dysfunction compared with subjects without obvious renal dysfunction (serum creatinine &lt; or = 88.4 mumol/L) and was negatively and positively correlated with serum creatinine and creatinine clearance, respectively.	Creatinine	236-246	lipoprotein(a)	Homo sapiens	8-13
1393477-4	1992	A positive correlation was found (r = 0.66, P &lt; 0.001) between the highest serum PLA2 activity, as measured early in the course of acute pancreatitis, and the highest N-acetyl-beta-glucosaminidase (NAG):creatinine ratio in the urine.	Creatinine	206-216	O-GlcNAcase	Homo sapiens	170-199
1393477-5	1992	The correlation between the highest serum concentration of immunoreactive pancreatic PLA2 and the highest urinary NAG:creatinine ratio was weaker (r = 0.36, P &lt; 0.05).	Creatinine	118-128	O-GlcNAcase	Homo sapiens	114-117
1524700-3	1992	The histamine H2-receptor antagonists may interfere with renal tubular excretion of creatinine and cationic drugs, resulting in elevated serum concentrations and reduced renal clearance.	Creatinine	84-94	histamine receptor H2	Homo sapiens	4-25
1352119-3	1992	Process workers at a polyurethane production unit were found to have up to 38 mumol MOCA mol-1 creatinine in their urine at the end of a work shift.	Creatinine	95-105	dedicator of cytokinesis 3	Homo sapiens	84-88
1292338-3	1992	The serum concentration of S-IL-2R was positively correlated to serum creatinine (r = 0.35) and complement factor D (r = 0.30), a low molecular weight protein, and the reciprocal value of S-IL-2R was negatively correlated to 51Cr-EDTA clearance (r = -0.35).	Creatinine	70-80	interleukin 2 receptor subunit alpha	Homo sapiens	29-34
1292338-4	1992	When measuring S-IL-2R and factor D in a wide range of serum creatinine (140-1,380 mumol/l), a high positive correlation was found between factor D and serum creatinine.	Creatinine	61-71	interleukin 2 receptor subunit alpha	Homo sapiens	17-22
1292338-4	1992	When measuring S-IL-2R and factor D in a wide range of serum creatinine (140-1,380 mumol/l), a high positive correlation was found between factor D and serum creatinine.	Creatinine	158-168	interleukin 2 receptor subunit alpha	Homo sapiens	17-22
1320227-8	1992	Patients with increased NAG excretion rate had lower Na excretion rate, lower fractional Na excretion and greater creatinine excretion than those with normal NAG excretion.	Creatinine	114-124	O-GlcNAcase	Homo sapiens	24-27
1728043-4	1992	Induction of renal injury by gentamicin was detectable within 4 days by increased levels of urinary N-acetyl beta-glucosaminidase (from 280 +/- 66 (mean +/- SD) to 910 +/- 210 nmol/mg creatinine), and within 9 days of initiating gentamicin treatment by increased serum creatinine (from 0.5 +/- 0.1 to 1.2 +/- 0.4 mg/dl).	Creatinine	184-194	O-GlcNAcase	Rattus norvegicus	100-129
1949170-5	1991	Kidney proximal tubule damage following CsA treatment alone was also reduced in animals coadministered DAZ, as indicated by reduced urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) (9.7 vs. 14.1 U/g creatinine) and by histological examination of kidney sections.	Creatinine	209-219	O-GlcNAcase	Rattus norvegicus	186-189
2066845-10	1991	The average t 1/2 beta for infants with serum creatinine level less than 1 mg/dl (88 mumol/L) was 5.0 hours, and 15.6 hours for those with serum creatinine level greater than 1 mg/dl.	Creatinine	46-56	interleukin 1 receptor like 1	Homo sapiens	12-22
2396670-7	1990	This EGF-related acceleration in DNA synthesis was associated with significantly lower peak BUN and serum creatinine levels, averaging 213 +/- 23 and 6.54 +/- 0.72 (SE) mg/dl, respectively, at 3 days in EGF-treated nephrotoxic rats compared with peak levels of 359 +/- 40 and 9.92 +/- 1.67 mg/dl (P less than 0.001, n = 7-16) at 5 days in non-EGF-treated nephrotoxic rats.	Creatinine	106-116	epidermal growth factor like 1	Rattus norvegicus	5-8
2396670-8	1990	EGF treatment also was associated with a return to near normal BUN and serum creatinine levels approximately 4 days earlier than that observed in non-EGF-treated animals.	Creatinine	77-87	epidermal growth factor like 1	Rattus norvegicus	0-3
2203466-5	1990	Values of these three low molecular weight proteins and of NAG were increased only in workers with urinary Cd higher than 10 micrograms/g creatinine.	Creatinine	138-148	O-GlcNAcase	Homo sapiens	59-62
2162268-10	1990	Treatment with exogenous epidermal growth factor attenuated the rise in serum creatinine by 4 days after acute tubular necrosis and after 7 days serum creatinine was lower than in animals that did not receive epidermal growth factor.	Creatinine	78-88	epidermal growth factor like 1	Rattus norvegicus	25-48
2162268-10	1990	Treatment with exogenous epidermal growth factor attenuated the rise in serum creatinine by 4 days after acute tubular necrosis and after 7 days serum creatinine was lower than in animals that did not receive epidermal growth factor.	Creatinine	151-161	epidermal growth factor like 1	Rattus norvegicus	25-48
2162268-13	1990	The increase in epidermal growth factor binding in the kidney after acute tubular necrosis and the attenuation of the increase in serum creatinine concentration by administration of exogenous epidermal growth factor, suggest a role for epidermal growth factor in recovery from ischaemic damage.	Creatinine	136-146	epidermal growth factor like 1	Rattus norvegicus	192-215
2162268-13	1990	The increase in epidermal growth factor binding in the kidney after acute tubular necrosis and the attenuation of the increase in serum creatinine concentration by administration of exogenous epidermal growth factor, suggest a role for epidermal growth factor in recovery from ischaemic damage.	Creatinine	136-146	epidermal growth factor like 1	Rattus norvegicus	192-215
33761993-7	2021	RESULTS: Mice pretreated with G-CSF/AMD3100 exhibited longer survival and lower serum creatinine and blood urea nitrogen (BUN) levels than mice treated with only G-CSF or saline.	Creatinine	86-96	colony stimulating factor 3 (granulocyte)	Mus musculus	30-35
33767704-4	2021	Here, by using a mouse model of renal ischemia-reperfusion, we found that myeloid cell-specific TSC1 knockout mice (termed Lyz-TSC1 cKO mice) had higher serum creatinine levels, more severe histological damage, and greater proinflammatory cytokine production than wild-type (WT) mice during the early phase after renal ischemia-reperfusion.	Creatinine	159-169	TSC complex subunit 1	Mus musculus	96-100
24001705-6	2013	The strongest correlation was found for serum cystatin C-based equations: the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine/cystatin C combined equation (r = 0.78) and the CKD-EPI cystatin C equation (r = 0.80).	Creatinine	138-148	cystatin C	Homo sapiens	46-56
22839580-12	2012	If CC was excluded from analysis, another marker of renal function (creatinine clearance) became an independent predictor of inhospital bleeding.	Creatinine	68-78	cystatin C	Homo sapiens	3-5
34895340-5	2021	Interestingly, we discovered that the number and cytotoxicity of NK cells are significantly reduced in IgAN patients, where both the number and marker genes of NK cells were negatively associated with the clinical parameters, including the levels of urine protein creatinine ratio (UPCR), serum galactose-deficient IgA1 and IgA.	Creatinine	264-274	IGAN1	Homo sapiens	103-107
34855654-9	2022	We found a significant correlation between admission BNP and central SBP (cSBP), urea, creatinine, arterial blood gases parameters, and left ventricular end-diastolic diameter (LVEDD).	Creatinine	87-97	natriuretic peptide B	Homo sapiens	53-56
34855654-10	2022	Concurrently, BNP at discharge was correlated with age, central DBP (cDBP), urea, creatinine, LVEDD, partial oxygen pressure (pO2), and oxygen saturation (SO2).	Creatinine	82-92	natriuretic peptide B	Homo sapiens	14-17
34855654-11	2022	Delta BNP was correlated with cSBP, peripheral SBP, urea, creatinine, pO2, and SO2.	Creatinine	58-68	natriuretic peptide B	Homo sapiens	6-9
34855654-12	2022	Linear regression analysis revealed that creatinine, and cSBP, were independent predictors of admission BNP, while urea and cDBP were the independent predictors of discharge BNP.	Creatinine	41-51	natriuretic peptide B	Homo sapiens	104-107
34792167-11	2021	Multivariable Cox regression analyses adjusted for age, comorbidity, smoking, dialysis vintage, serum creatinine, hemoglobin, C-reactive protein, serum albumin, iPTH, LDL, and Kt/V likewise indicated that elevated Ang-2 concentrations are associated with all-cause mortality in male (HR, 3.294, 95% CI, 1.768-6.138, p = 0.0002), but not in female end-stage kidney disease patients on hemodialysis (HR, 1.084, 95% CI, 0.476-2.467, p = 0.847).	Creatinine	102-112	angiopoietin 2	Homo sapiens	214-219
34344244-7	2021	Results: Double negative CD69 and CD56 (47.9%) multiple myeloma cases were associated with high serum beta2 microglobulin, creatinine, calcium and low serum albumin.	Creatinine	123-133	CD69 molecule	Homo sapiens	25-29
34487756-1	2021	AIM: To detect the expression levels of fasting serum fructose and ketohexokinase (KHK) in patients with type 2 diabetes mellitus (T2DM) at different stages of urinary albumin creatinine ratios (UACR) and serum uric acid (sUA).	Creatinine	176-186	ketohexokinase	Homo sapiens	67-81
34487756-1	2021	AIM: To detect the expression levels of fasting serum fructose and ketohexokinase (KHK) in patients with type 2 diabetes mellitus (T2DM) at different stages of urinary albumin creatinine ratios (UACR) and serum uric acid (sUA).	Creatinine	176-186	ketohexokinase	Homo sapiens	83-86
34254213-9	2021	Finally, exogenous administration of apelin normalized the serum level of creatinine and urea nitrogen and the urine levels of NGAL and Kim-1.	Creatinine	74-84	apelin	Mus musculus	37-43
34218203-6	2021	The correlation between miR-320a expression and EOPE clinical indicators (mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count) was analyzed.	Creatinine	142-152	microRNA 320a	Homo sapiens	24-32
34314052-7	2021	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), the glycogen synthase kinase-3beta inhibitor, ameliorated renal injury under I/R, activated autophagy and markedly increased expression of AQPs and sodium transporters in the kidney, which was associated with improved urine output and creatinine clearance in rats.	Creatinine	295-305	glycogen synthase kinase 3 beta	Rattus norvegicus	64-94
34296783-12	2021	Transforming growth factor-beta and connective tissue growth factor were both positively correlated with homocysteine and creatinine.	Creatinine	122-132	cellular communication network factor 2	Homo sapiens	36-67
34278996-1	2021	INTRODUCTION: Many factors, such as increased serum creatinine, increased blood pressure and abnormal urine protein, may lead to poor prognosis of IgA nephropathy (IgAN).	Creatinine	52-62	IGAN1	Homo sapiens	164-168
34206784-17	2021	Pigs fed MTAF, AFP, and AFPA had lower (p < 0.05) urea nitrogen/creatinine than CON.	Creatinine	64-74	alpha fetoprotein	Sus scrofa	15-18
34268385-9	2021	In males, different ALDH2 genotypes exhibited significant differences in several biochemical analytes, including body mass index (BMI), blood glucose (Glu), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), UA, glutamyl transpeptidase (GGT), and creatinine (Cr) (P<0.05).	Creatinine	266-276	aldehyde dehydrogenase 2 family member	Homo sapiens	20-25
34268385-9	2021	In males, different ALDH2 genotypes exhibited significant differences in several biochemical analytes, including body mass index (BMI), blood glucose (Glu), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), UA, glutamyl transpeptidase (GGT), and creatinine (Cr) (P<0.05).	Creatinine	278-280	aldehyde dehydrogenase 2 family member	Homo sapiens	20-25
34268385-12	2021	The effect of the ALDH2 polymorphism on UA was still significant after further adjustment for factors including BMI, Glu, TC, HDL-C, Cr, and GGT.	Creatinine	133-135	aldehyde dehydrogenase 2 family member	Homo sapiens	18-23
35059855-1	2022	BACKGROUND: In pediatric cancer patients, the estimated glomerular filtration rate based on serum cystatin C (CysC) was reported to be suitable for estimating kidney function because of low serum creatinine (Cr) and high serum beta2-microglobulin.	Creatinine	208-210	cystatin C	Homo sapiens	98-108
35059855-1	2022	BACKGROUND: In pediatric cancer patients, the estimated glomerular filtration rate based on serum cystatin C (CysC) was reported to be suitable for estimating kidney function because of low serum creatinine (Cr) and high serum beta2-microglobulin.	Creatinine	208-210	cystatin C	Homo sapiens	110-114
35405247-7	2022	Spearman"s analysis showed that CD19(+)CD5(+) B cells were negatively correlated with high sensitivity C-reactive protein (hsCRP), beta2-microglobulin (beta2-MG), serum creatinine (SCr), pro-brain natriuretic peptide (pro-BNP), high-sensitivity troponin T (TNT-hs), left ventricle end-diastolic dimension (LVDD), left ventricle end-systolic dimension (LVSD) and left ventricular mass (LVM), and CD19(+)CD5(-) B cells were negatively correlated with beta2-MG, SCr, pro-BNP and TNT-hs (P < 0.05).	Creatinine	169-179	CD19 molecule	Homo sapiens	32-36
35218571-5	2022	Compared to the wild-type mice, TIMP2-deficient mice demonstrated lower serum creatinine levels and decreased ER stress-mediated apoptosis when subjected to CLP.	Creatinine	78-88	tissue inhibitor of metalloproteinase 2	Mus musculus	32-37
35443444-17	2022	CONCLUSION: We found out that both serum creatinine and serum cystatin C were significantly increased across CKD groups but cystatin C is a better predictor of CKD than creatinine in stages with eGFR>=60 ml/min/1.73 m2 as serum cystatin C was found to be raised contrary to serum creatinine which was within normal limits, although in stages with eGFR<60 ml/min/1.73 m2 there was no significant difference between the two.	Creatinine	41-51	cystatin C	Homo sapiens	124-134
35443444-17	2022	CONCLUSION: We found out that both serum creatinine and serum cystatin C were significantly increased across CKD groups but cystatin C is a better predictor of CKD than creatinine in stages with eGFR>=60 ml/min/1.73 m2 as serum cystatin C was found to be raised contrary to serum creatinine which was within normal limits, although in stages with eGFR<60 ml/min/1.73 m2 there was no significant difference between the two.	Creatinine	41-51	cystatin C	Homo sapiens	228-238
35443444-17	2022	CONCLUSION: We found out that both serum creatinine and serum cystatin C were significantly increased across CKD groups but cystatin C is a better predictor of CKD than creatinine in stages with eGFR>=60 ml/min/1.73 m2 as serum cystatin C was found to be raised contrary to serum creatinine which was within normal limits, although in stages with eGFR<60 ml/min/1.73 m2 there was no significant difference between the two.	Creatinine	280-290	cystatin C	Homo sapiens	62-72
35443444-17	2022	CONCLUSION: We found out that both serum creatinine and serum cystatin C were significantly increased across CKD groups but cystatin C is a better predictor of CKD than creatinine in stages with eGFR>=60 ml/min/1.73 m2 as serum cystatin C was found to be raised contrary to serum creatinine which was within normal limits, although in stages with eGFR<60 ml/min/1.73 m2 there was no significant difference between the two.	Creatinine	280-290	cystatin C	Homo sapiens	124-134
35220678-2	2022	However, whether METS-IR is associated with the urinary albumin-to-creatinine ratio (UACR) is not well known.	Creatinine	67-77	ETS variant transcription factor 3	Homo sapiens	17-21
35228908-6	2022	BNP and double-dose nicorandil significantly decreased the change of serum creatinine (SCr) levels with mean difference (MD) of -6.98, (-10.01, -3.95) for BNP, -8.78, (-11.63, -5.93) for double-dose nicorandil.	Creatinine	75-85	natriuretic peptide B	Homo sapiens	0-3
35228908-6	2022	BNP and double-dose nicorandil significantly decreased the change of serum creatinine (SCr) levels with mean difference (MD) of -6.98, (-10.01, -3.95) for BNP, -8.78, (-11.63, -5.93) for double-dose nicorandil.	Creatinine	75-85	natriuretic peptide B	Homo sapiens	155-158
35203629-6	2022	In parallel, CCL9-blockade raised serum creatinine and urea levels as readouts of kidney dysfunction.	Creatinine	40-50	chemokine (C-C motif) ligand 9	Mus musculus	13-17
35150223-8	2022	RESULTS: Preoperative VAT2 was correlated with preoperative serum creatinine and all 24 HU (R2: 0.23-0.43, p = < 0.001-0.030).	Creatinine	66-76	solute carrier family 18 member A2	Homo sapiens	22-26
35093023-1	2022	BACKGROUND: The urine protein-creatinine ratio (UPCR) in a spot first-morning urine sample is used to estimate 24-h urine proteinuria (24hUP) in patients who underwent urine protein testing.	Creatinine	30-40	uridine phosphorylase 1	Homo sapiens	137-140
35088417-6	2022	IRF2 knockdown suppressed the levels of creatinine, blood urea nitrogen, and kidney injury molecule 1 and decreased the renal injury score in mice.	Creatinine	40-50	interferon regulatory factor 2	Mus musculus	0-4
34857709-4	2022	METHODS: The SPA Project is a multicenter, observational, cross-sectional, cohort study investigating healthy children, aged 5-8 years as to sodium and fluid intake by means of urinary sodium and creatinine from multiple samples taken in different days in order to characterize them in lower/higher sodium and lower/higher fluid intake.	Creatinine	196-206	surfactant protein A1	Homo sapiens	13-16
34967426-9	2022	We were determined that the vast majority of patients with perforated appendicitis were male; had more frequent chronic kidney disease and post-operative local complications; had increased leukocytes, neutrophils, blood urea nitrogen, creatinine, and total bilirubin; and had reduced albumin; and these differences were statistically significant (all values p<0.05).	Creatinine	235-245	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	175-178
35498888-1	2022	Background: Randomized controlled trials (RCTs) have been conducted, stratifying idiopathic immunoglobulin A nephropathy (IgAN) patients based on the laboratory findings (serum creatinine, estimated glomerular filtration rate (eGFR) and daily proteinuria).	Creatinine	177-187	IGAN1	Homo sapiens	122-126
2592559-6	1989	This accelerated DNA replicative process was associated with significantly lower peak blood urea nitrogen (BUN) and serum creatinine levels, averaging 63 +/- 20 and 3.1 +/- 0.4 mg/dl in EGF-treated ischemic rats compared with 149 +/- 20 and 5.1 +/- 0.1 mg/dl, respectively, in nontreated ischemic rats, and was also associated with a return to near normal BUN and serum creatinine levels in EGF-treated animals approximately 4 d earlier than that observed in nontreated animals.	Creatinine	122-132	epidermal growth factor like 1	Rattus norvegicus	186-189
2592559-6	1989	This accelerated DNA replicative process was associated with significantly lower peak blood urea nitrogen (BUN) and serum creatinine levels, averaging 63 +/- 20 and 3.1 +/- 0.4 mg/dl in EGF-treated ischemic rats compared with 149 +/- 20 and 5.1 +/- 0.1 mg/dl, respectively, in nontreated ischemic rats, and was also associated with a return to near normal BUN and serum creatinine levels in EGF-treated animals approximately 4 d earlier than that observed in nontreated animals.	Creatinine	370-380	epidermal growth factor like 1	Rattus norvegicus	186-189
2801729-6	1989	RESULTS: The group with FSGS had a higher percentage of blacks (96% versus 46%) and intravenous drug abusers (42% versus 17%), and had a higher mean serum creatinine level (5.4 mg/dL versus 1.0 mg/dL) than the group of HIV-infected subjects without glomerular disease.	Creatinine	155-165	actinin alpha 4	Homo sapiens	24-28
2473347-2	1989	The infusion of ANP alone (50 ng/kg/min) induced a natriuretic action with increments in renal blood flow (RBF) and creatinine clearance (Ccr).	Creatinine	116-126	natriuretic peptides A	Oryctolagus cuniculus	16-19
2645498-1	1989	Urinary epidermal growth factor (EGF) excretion was calculated as ng EGF per mg creatinine and ng EGF per 24 hr.	Creatinine	80-90	epidermal growth factor like 1	Rattus norvegicus	8-31
2645498-1	1989	Urinary epidermal growth factor (EGF) excretion was calculated as ng EGF per mg creatinine and ng EGF per 24 hr.	Creatinine	80-90	epidermal growth factor like 1	Rattus norvegicus	33-36
3044273-3	1988	However, NAG index (NAG activity/urinary creatinine) rose markedly in all patients.	Creatinine	41-51	O-GlcNAcase	Homo sapiens	9-12
3415783-3	1988	Mean urinary albumin excretion was 23.2 +/- 34.3 mg/day and mean urinary NAG excretion was 45.1 +/- 22.9 nmol/hr/mg creatinine.	Creatinine	116-126	O-GlcNAcase	Homo sapiens	73-76
3402185-9	1988	The basal excretion of PGI-M was 142 +/- 25 pg/mg creatinine.	Creatinine	50-60	glucose-6-phosphate isomerase	Homo sapiens	23-26
3402185-11	1988	During the recovery period the outflow of PGI-M was significantly higher than at rest (482 +/- 145 pg/mg creatinine; P less than 0.01).	Creatinine	105-115	glucose-6-phosphate isomerase	Homo sapiens	42-45
3289506-5	1988	In cases where greater than 1,000 micrograms/g creatinine of beta 2-microglobulinuria was observed (at the time cadmium exposure ended), almost all individuals exposed to cadmium showed deterioration of beta 2-microglobulinuria, whereas in the case of less than 1,000 micrograms/g creatinine of beta 2-microglobulinuria, no significant changes were observed.	Creatinine	47-57	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	61-67
3289506-5	1988	In cases where greater than 1,000 micrograms/g creatinine of beta 2-microglobulinuria was observed (at the time cadmium exposure ended), almost all individuals exposed to cadmium showed deterioration of beta 2-microglobulinuria, whereas in the case of less than 1,000 micrograms/g creatinine of beta 2-microglobulinuria, no significant changes were observed.	Creatinine	281-291	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	61-67
3394526-5	1988	There was a trend for an association between elevated NAGs and reduced creatinine clearance (P less than .08), but no association was found between concentrating ability and either elevated NAG or reduced creatinine clearance.	Creatinine	71-81	O-GlcNAcase	Homo sapiens	54-57
3620550-3	1987	The urinary NAG index (NAG is expressed as the ratio of the enzyme activity to milligrams of creatinine) during the first month of life was significantly elevated when compared with that of any other succeeding period and gradually decreased during the first year of life.	Creatinine	93-103	O-GlcNAcase	Homo sapiens	12-15
3620550-3	1987	The urinary NAG index (NAG is expressed as the ratio of the enzyme activity to milligrams of creatinine) during the first month of life was significantly elevated when compared with that of any other succeeding period and gradually decreased during the first year of life.	Creatinine	93-103	O-GlcNAcase	Homo sapiens	23-26
2907868-5	1987	The circadian acrophases of urinary GGT and LAP activity led in timing the circadian rhythms in urine volume and creatinine excretion by about 13 hr.	Creatinine	113-123	leucine aminopeptidase 3	Rattus norvegicus	44-47
2949392-7	1986	There was a strong correlation between urinary beta TG excretion and plasma creatinine concentration (r = 0.8, p less than 0.0001) and plasma beta 2-microglobulin concentration (r = 0.9, p less than 0.0001).	Creatinine	76-86	pro-platelet basic protein	Homo sapiens	47-54
3932466-4	1985	The patients" high 1 X 10(5) mol wt VIII: CAg level correlated with increased concentrations of serum creatinine, F1+2 (a polypeptide released upon prothrombin activation), and with von Willebrand factor.	Creatinine	102-112	cytochrome c oxidase subunit 8A	Homo sapiens	36-40
4036932-2	1985	Urinary NAG excretion in 13 healthy children was 5.84 +/- 9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean +/- SD) compared with 35.61 +/- 42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 +/- 13.69 nmole/hr/mg of creatinine in ten children with absorptive hypercalciuria.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	8-11
4036932-2	1985	Urinary NAG excretion in 13 healthy children was 5.84 +/- 9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean +/- SD) compared with 35.61 +/- 42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 +/- 13.69 nmole/hr/mg of creatinine in ten children with absorptive hypercalciuria.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	90-93
4036932-2	1985	Urinary NAG excretion in 13 healthy children was 5.84 +/- 9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean +/- SD) compared with 35.61 +/- 42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 +/- 13.69 nmole/hr/mg of creatinine in ten children with absorptive hypercalciuria.	Creatinine	157-167	O-GlcNAcase	Homo sapiens	8-11
4036932-2	1985	Urinary NAG excretion in 13 healthy children was 5.84 +/- 9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean +/- SD) compared with 35.61 +/- 42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 +/- 13.69 nmole/hr/mg of creatinine in ten children with absorptive hypercalciuria.	Creatinine	157-167	O-GlcNAcase	Homo sapiens	8-11
4055989-3	1985	Urinary IgA and IgG concentrations were higher in IgAN than in either control group and correlated positively with the serum creatinine concentration as well as the urinary protein excretion (P less than 0.01).	Creatinine	125-135	IGAN1	Homo sapiens	50-54
6335757-4	1984	Renal clearance of EGF exceeded that of creatinine, and after bilateral nephrectomy or bilateral ligation of the ureters, the concentration of creatinine in serum increased, while the concentration of EGF was below the detection limit of the assay.	Creatinine	143-153	epidermal growth factor like 1	Rattus norvegicus	19-22
6480810-6	1984	In contrast, all normal menopausal women studied had easily detectable levels of hCG immunoreactivity in their urine, with a mean value of 0.123 ng hCG/mg creatinine.	Creatinine	155-165	chorionic gonadotropin subunit beta 5	Homo sapiens	81-84
6480810-6	1984	In contrast, all normal menopausal women studied had easily detectable levels of hCG immunoreactivity in their urine, with a mean value of 0.123 ng hCG/mg creatinine.	Creatinine	155-165	chorionic gonadotropin subunit beta 5	Homo sapiens	148-151
6509805-2	1984	IGAN patients with macroscopical hematuria (macro-H) differ from the other IGAN patients in 9 aspects: history, HLA-DR, Gm-allotypes, actuarial kidney survival, initial creatinine clearance, initial proteinuria, initial microhematuria, age at presentation and light microscopy of the renal biopsy.	Creatinine	169-179	IGAN1	Homo sapiens	0-4
6152561-1	1984	Urinary arylsulfatase A activity expressed as units/mg of urinary creatinine was significantly increased in bladder cancer patients, but not in patients with other genitourinary tract disorders, such as cystitis, urethritis and prostatic cancer, nor in patients with non-urological malignant diseases.	Creatinine	66-76	arylsulfatase A	Homo sapiens	8-23
6231599-4	1984	During the exudation period the ultimate serum half-lives (t 1/2 beta) were 1.17 to 1.4 h, 1.73 to 1.78 h and 3.3 h respectively with creatinine clearances of 111-131, 60-94 and 14 ml/min/1.73 m2.	Creatinine	134-144	interleukin 1 receptor like 1	Homo sapiens	59-69
6588212-3	1984	In kidneys with VUR of grade IIb to III degree, urinary concentration of CMZ showed rather higher than that we expected from their creatinine clearance.	Creatinine	131-141	VUR	Homo sapiens	16-19
6588212-4	1984	On the contrary in kidneys with VUR of grade IV degree and hydronephrosis, urinary concentration of CMZ showed rather lower compared to their creatinine clearance.	Creatinine	142-152	VUR	Homo sapiens	32-35
6532266-4	1984	In patients with normal serum creatinine levels prior to the IVP, urinary NAG was very elevated at 24 hours and had returned to almost normal values 48 hours after intravenous pyelography.	Creatinine	30-40	O-GlcNAcase	Homo sapiens	74-77
6709952-2	1984	In males, the NAG activity in the kidney was significantly higher (p less than 0.001), and the urinary NAG activity (unit/g creatinine) was 8-fold higher than those for females, while plasma NAG levels were significantly lower (p less than 0.001).	Creatinine	124-134	O-GlcNAcase	Mus musculus	103-106
6709952-2	1984	In males, the NAG activity in the kidney was significantly higher (p less than 0.001), and the urinary NAG activity (unit/g creatinine) was 8-fold higher than those for females, while plasma NAG levels were significantly lower (p less than 0.001).	Creatinine	124-134	O-GlcNAcase	Mus musculus	103-106
6872263-3	1983	NAG excretion expressed as nmol X h-1 X mg-1 of urinary creatinine was higher in children with upper UTI (mean +/- SE 906 +/- 236) than in those with lower UTI (145 +/- 23) or healthy children (151.6 +/- 10) (p less than 0.01 by Duncan"s test).	Creatinine	56-66	O-GlcNAcase	Homo sapiens	0-3
6347577-3	1983	Thirty-four children from a diabetic summer camp were found to have urinary NAG to creatinine ratios significantly above those of normal controls of similar age (5.22 +/- 1.19 versus 1.51 +/- 0.17 U).	Creatinine	83-93	O-GlcNAcase	Homo sapiens	76-79
6347577-5	1983	In a closely followed group of 40 clinic patients, urinary NAG to creatinine ratio was again found to be significantly increased over normal controls (7.55 +/- 0.70 versus 1.51 +/- 0.17 U; P less than 0.05).	Creatinine	66-76	O-GlcNAcase	Homo sapiens	59-62
6347577-6	1983	Again, urinary NAG was positively correlated with HbA1c (r = 0.62; P less than 0.001) and urinary albumin to creatinine ratio (r = 0.47; P less than 0.01).	Creatinine	109-119	O-GlcNAcase	Homo sapiens	15-18
6347577-8	1983	Thus, these data suggest that urinary NAG to creatinine ratio appears to be a reflection of blood sugar control.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	38-41
6189234-7	1983	Increased urinary beta-TG values correlated with decreased creatinine clearance, but the difference between diabetics and normals was still observed when patients with a creatinine clearance of less than 100 ml/min were excluded.	Creatinine	59-69	pro-platelet basic protein	Homo sapiens	18-25
6189234-7	1983	Increased urinary beta-TG values correlated with decreased creatinine clearance, but the difference between diabetics and normals was still observed when patients with a creatinine clearance of less than 100 ml/min were excluded.	Creatinine	170-180	pro-platelet basic protein	Homo sapiens	18-25
6354940-6	1983	A small increase in the prevalence of higher activities of the urinary enzyme N-acetyl-beta-glucosaminidase and gamma glutamyl transferase is observed when the urinary mercury concentration exceeds 100 micrograms/g creatinine.	Creatinine	215-225	O-GlcNAcase	Homo sapiens	78-107
6819368-5	1982	However, the mean values of urinary beta-galactosidase in the control and acute MI groups were 158.68 and 333.3 nmol/mg creatinine/hr, respectively (p less than 0.046).	Creatinine	120-130	galactosidase beta 1	Homo sapiens	36-54
7102609-5	1982	The circadian acrophase of urinary NAG activity lags in timing the circadian rhythms in urine volume, Na and K excretion, and urinary free adrenalin and noradrenalin, by about five to ten hours and the circadian rhythm in creatinine excretion by about 11 hours.	Creatinine	222-232	O-GlcNAcase	Homo sapiens	35-38
6460973-7	1982	The theoretical Tb 1/2 for zero creatinine clearance was 4.7 hours.	Creatinine	32-42	receptor accessory protein 5	Homo sapiens	16-22
7102363-4	1982	Patients with pyelonephritic changes but normal serum creatinine had enzyme activity towards the upper limit of the normal range whilst patients with pyelonephritic changes and decreased renal function (high serum creatinine) showed increased excretion of urinary beta-hexosaminidase.	Creatinine	214-224	O-GlcNAcase	Homo sapiens	264-283
7148509-8	1982	Careful monitoring of blood glucose, serum electrolytes, serum creatinine and blood pressure will aid in the early detection of the adverse reaction.	Creatinine	63-73	activation induced cytidine deaminase	Homo sapiens	98-101
6459902-4	1982	There was a significant inverse correlation between plasma beta-TG and creatinine clearance.	Creatinine	71-81	pro-platelet basic protein	Homo sapiens	59-66
6175048-2	1981	The increase in beta-TG was highly correlated with BUN (r = 0.651, p less than 0.01), creatinine (r = 0.778, p less than 0.01) and creatinine clearance ( t = -0.723, p less than 0.01).	Creatinine	86-96	pro-platelet basic protein	Homo sapiens	16-23
6175048-2	1981	The increase in beta-TG was highly correlated with BUN (r = 0.651, p less than 0.01), creatinine (r = 0.778, p less than 0.01) and creatinine clearance ( t = -0.723, p less than 0.01).	Creatinine	131-141	pro-platelet basic protein	Homo sapiens	16-23
6460426-1	1981	The urinary excretion of beta-hexosaminidase in relation to creatinine was studied during one year in 30 consecutive patients with polycystic kidney disease (S-creatinine 75-1 000 micro mol/l) and 30 healthy controls.	Creatinine	60-70	O-GlcNAcase	Homo sapiens	25-44
6460426-2	1981	The excretion of beta-hexosaminidase was significantly increased in the patients and was positively correlated to S-creatinine and to the relative increase in S-creatinine during the year of the study.	Creatinine	116-126	O-GlcNAcase	Homo sapiens	17-36
6460426-2	1981	The excretion of beta-hexosaminidase was significantly increased in the patients and was positively correlated to S-creatinine and to the relative increase in S-creatinine during the year of the study.	Creatinine	161-171	O-GlcNAcase	Homo sapiens	17-36
6454327-3	1981	The children with rapidly progressive uremia had higher activities of Na+, K+-ATPase at the corresponding serum creatinine concentration than those with slowly progressive uremia.	Creatinine	112-122	dynein axonemal heavy chain 8	Homo sapiens	78-84
376226-3	1979	Urinary beta-glucuronidase, expressed as the ratio of enzyme activity to creatinine concentration, was determined by a colorimetric technique following dialysis of urine to remove endogenous activators and inhibitors.	Creatinine	73-83	glucuronidase beta	Homo sapiens	8-26
95329-2	1979	In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine.	Creatinine	108-118	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	50-56
920254-2	1977	With the aid of tritiated water it was possible to estimate the fluid turnover in the cysts and compare it with their volume, pressure and potassium and creatinine levels.	Creatinine	153-163	activation induced cytidine deaminase	Homo sapiens	9-12
77073-9	1977	Normal individuals (n = 210) excreted 0.3 +/- .02 (ave. +/- SE) mg EDC1 per g creatinine.	Creatinine	78-88	alpha-1-microglobulin/bikunin precursor	Homo sapiens	67-71
77073-10	1977	In 18 non-neoplastic diseases (n = 75), urinary EDC1 was .5 +/- .06 mg/g creatinine.	Creatinine	73-83	alpha-1-microglobulin/bikunin precursor	Homo sapiens	48-52
1252848-2	1976	When the urinary NAG levels of 60 patients with rheumatoid arthritis (RA) were measured a highly significant difference was detected between the mean urinary NAG excretion of the patients with RA (341 +/- 294-92 nmol h-1 mg creatinine-1) and that of 60 matched controls (67-53 +/- 16-93 nmol h-1 mg creatinine-1).	Creatinine	224-234	O-GlcNAcase	Homo sapiens	17-20
1252848-2	1976	When the urinary NAG levels of 60 patients with rheumatoid arthritis (RA) were measured a highly significant difference was detected between the mean urinary NAG excretion of the patients with RA (341 +/- 294-92 nmol h-1 mg creatinine-1) and that of 60 matched controls (67-53 +/- 16-93 nmol h-1 mg creatinine-1).	Creatinine	299-309	O-GlcNAcase	Homo sapiens	17-20
33850530-11	2021	IL-37 levels were positively correlated with creatinine, C-reactive protein and homocysteine levels.	Creatinine	45-55	interleukin 37	Homo sapiens	0-5
34047946-7	2021	Compared with non-PIH women, women who developed PIH had lower urinary Sr concentrations (131.26 vs. 174.98 microg/L creatinine, P<0.01).	Creatinine	117-127	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	49-52
34047946-8	2021	With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing, the risk of PIH decreased significantly [adjusted OR=0.60 (95%CI: 0.51, 0.72)].	Creatinine	41-51	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	107-110
34032712-9	2021	Patients with severe HTGP had significantly more pancreatic necrosis, higher values of Blood urea nitrogen and creatinine, longer prothrombin time and activated partial thromboplastin time on admission and higher CRP48 than not severe HTGP (P < .05).The severity of HTGP was significantly related to clinical factors including fever, altered mental status, rapid pulse, hypotension, and pancreatic necrosis.	Creatinine	111-121	transglutaminase 4	Homo sapiens	21-25
34043281-2	2021	The present study aimed to determine the predictive value of serum creatinine-cystatin C ratio, that is, "Sarcopenia Index" (SI) as a surrogate marker of sarcopenia, and investigate its association with clinical outcomes after TAVR.	Creatinine	67-77	cystatin C	Homo sapiens	78-88
34042533-6	2021	The correlation analysis showed that serum adropin levels were correlated negatively with Age, CVD history, DM history, C-reactive protein, type B natriuretic peptide, phosphorus, intact parathyroid hormone, carotid artery plaque amount and carotid intima-media thickness (CIMT), left ventricular septal thickness (LVSTd), and left ventricular posterior wall thickness, whereas it was correlated positively with albumin, hemoglobin, serum creatinine and Kt/V, and ejection fraction value.	Creatinine	439-449	energy homeostasis associated	Homo sapiens	43-50
33377278-12	2021	Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX-2-dependent normalization of creatinine clearance and sodium excretion.	Creatinine	97-107	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	64-69
33647713-7	2021	IL-1beta, IL-6 and IL-18 levels were significant elevated in gout patients with tophus than those without tophus; Serum IL-37 were positively correlated with CRP and ESR, as well as with IL-1beta, IL-6 and IL-18, negatively correlated with Ccr, and not correlated with UA, creatinine (Cr) and triglyceride (TG) in gout patients.	Creatinine	273-283	interleukin 37	Homo sapiens	120-125
33647713-7	2021	IL-1beta, IL-6 and IL-18 levels were significant elevated in gout patients with tophus than those without tophus; Serum IL-37 were positively correlated with CRP and ESR, as well as with IL-1beta, IL-6 and IL-18, negatively correlated with Ccr, and not correlated with UA, creatinine (Cr) and triglyceride (TG) in gout patients.	Creatinine	285-287	interleukin 37	Homo sapiens	120-125
33617143-8	2021	SLE disease activity index (SLEDAI), proteinuria and serum creatinine were independently correlated with miR-181a and miR-223 among SLE patients by linear regression analysis.	Creatinine	59-69	microRNA 223	Homo sapiens	118-125
33478971-6	2021	EXT1/EXT2-positive patients were significantly younger (P=0.01), had significantly lower serum creatinine levels (P=0.02), were significantly more likely to present with proteinuria >=3.5 g/24 h (P=0.009), and had significantly less chronicity features (glomerulosclerosis, P=0.001 or interstitial fibrosis and tubular atrophy, P<0.001) on kidney biopsy.	Creatinine	95-105	exostosin glycosyltransferase 1	Homo sapiens	0-4
33691922-5	2021	RESULTS: Compared with the non-VUR group, the VUR group had a significantly higher proportion of children with non-Escherichia coli urinary tract infection, hydronephrosis (the severity of hydronephrosis increased with the grade of VUR), abnormal 99mTc-DMSA renal scanning findings, elevated ratios of urinary albumin, urinary IgG and urinary transferrin to creatinine, increased residual urine volume, and increased detrusor leak point pressure (P < 0.05).	Creatinine	358-368	VUR	Homo sapiens	46-49
33691922-5	2021	RESULTS: Compared with the non-VUR group, the VUR group had a significantly higher proportion of children with non-Escherichia coli urinary tract infection, hydronephrosis (the severity of hydronephrosis increased with the grade of VUR), abnormal 99mTc-DMSA renal scanning findings, elevated ratios of urinary albumin, urinary IgG and urinary transferrin to creatinine, increased residual urine volume, and increased detrusor leak point pressure (P < 0.05).	Creatinine	358-368	VUR	Homo sapiens	46-49
33595099-7	2021	Multiple linear regression analysis showed that CLR for syndecan-1 was positively associated with the creatinine clearance (P< 0.0032) and the urine flow (P< 0.015).	Creatinine	102-112	syndecan 1	Homo sapiens	56-66
33583418-5	2021	The highest average SBP (> 120 mmHg) was observed among those with low Sb (<= 0.21 mug/dL) high Cd (> 0.22 mug/g creatinine) and high Pb (> 2.55 mug/dL) biomarkers.	Creatinine	113-123	selenium binding protein 1	Homo sapiens	20-23
33172686-2	2021	A new sarcopenia index (SI), defined as serum creatinine (Cr) x cystatin C (CysC)-based glomerular filtration rate (eGFRCysC), has been reported to be an objective surrogate marker for sarcopenia.	Creatinine	46-56	cystatin C	Homo sapiens	64-74
33207943-7	2021	Meta-analysis indicated that the highest versus lowest category of cystatin C level was associated with higher risk of MACE (HR 2.28; 95% CI 1.92-2.71) and all-cause mortality (HR 2.89; 95% CI 1.43-5.83) after adjustment for estimated glomerular filtration rate (eGFR) or creatinine.	Creatinine	272-282	cystatin C	Homo sapiens	67-77
33520107-12	2021	Bivariate analysis revealed that serum Dickkopf-1 levels were positively correlated with hemoglobin A1c level (r = 0.368, P < 0.01) and estimated glomerular filtration rate (r = 0.339, P < 0.01), but negatively correlated with diabetes duration (r = -0.231, P = 0.050), systolic blood pressure (r = -0.369, P = 0.001), serum creatinine level (r = -0.325, P < 0.01), and UACR (r = -0.459, P < 0.01).	Creatinine	325-335	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	39-49
33488671-5	2020	The royalblue module in WGCNA was closely related to creatinine and estimated glomerular filtration rate (eGFR) in IgAN patients.	Creatinine	53-63	IGAN1	Homo sapiens	115-119
33488671-10	2020	POSTN level in the kidney tissue of IgAN patients was positively correlated with creatinine level and negatively correlated with eGFR.	Creatinine	81-91	IGAN1	Homo sapiens	36-40
33725696-9	2021	At baseline, log sST2 and galectin-3 were directly associated with the serum creatinine (Cr) and urine protein-to-Cr ratio.	Creatinine	77-87	galectin 3	Homo sapiens	26-36
33725696-9	2021	At baseline, log sST2 and galectin-3 were directly associated with the serum creatinine (Cr) and urine protein-to-Cr ratio.	Creatinine	89-91	galectin 3	Homo sapiens	26-36
33725696-9	2021	At baseline, log sST2 and galectin-3 were directly associated with the serum creatinine (Cr) and urine protein-to-Cr ratio.	Creatinine	114-116	galectin 3	Homo sapiens	26-36
33523719-8	2021	Plasma BDNF and MGP levels were both correlated with the Agatston score even after adjustment for age, total cholesterol level, triglycerides, low-density lipoprotein level, creatinine clearance rate, and the presence of hypertension and diabetes mellitus.	Creatinine	174-184	matrix Gla protein	Homo sapiens	16-19
33437955-10	2020	Residual plots demonstrated heteroscedasticity and greater imprecision at higher mGFR levels (P<0 001), from increased variance corresponding to higher absolute values and unreliable prediction by serum creatinine of high mGFR.	Creatinine	203-213	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	222-226
33011273-7	2020	Further, the total serum cholesterol, triglycerides, and urinary albumin/creatinine levels also significantly decreased by APX-115 treatment.	Creatinine	73-83	shroom family member 1	Mus musculus	123-126
32434723-0	2020	Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.	Creatinine	62-72	apolipoprotein L1	Homo sapiens	0-17
32434723-0	2020	Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.	Creatinine	62-72	apolipoprotein L1	Homo sapiens	19-24
32434723-13	2020	CONCLUSIONS: African American cardiac surgery patients homozygous for APOL1 chronic kidney disease risk variants averaged a more than 2-fold higher postoperative creatinine rise even after adjustment for other risk factors, suggesting these alleles also are independent risk factors for AKI.	Creatinine	162-172	apolipoprotein L1	Homo sapiens	70-75
32868633-8	2020	Alanine aminotransferase (ALT) levels were a significant factor associated with a high initial trough concentration of voriconazole (> 5.5 microg/mL) after adjusting for sex, age, weight, and serum creatinine (OR 5.42; 95% CI 1.34-21.97).	Creatinine	198-208	glutamic--pyruvic transaminase	Homo sapiens	0-24
32522118-7	2020	Changes in HBP after getting up were significantly correlated with serum creatinine levels and the urinary albumin-to-creatinine ratio.Conclusions: These findings imply that elevated HBP-morning in winter reflects the response of BP to cold after getting up.	Creatinine	73-83	heme binding protein 1	Homo sapiens	11-14
32522118-7	2020	Changes in HBP after getting up were significantly correlated with serum creatinine levels and the urinary albumin-to-creatinine ratio.Conclusions: These findings imply that elevated HBP-morning in winter reflects the response of BP to cold after getting up.	Creatinine	73-83	heme binding protein 1	Homo sapiens	183-186
32522118-7	2020	Changes in HBP after getting up were significantly correlated with serum creatinine levels and the urinary albumin-to-creatinine ratio.Conclusions: These findings imply that elevated HBP-morning in winter reflects the response of BP to cold after getting up.	Creatinine	118-128	heme binding protein 1	Homo sapiens	11-14
32522118-7	2020	Changes in HBP after getting up were significantly correlated with serum creatinine levels and the urinary albumin-to-creatinine ratio.Conclusions: These findings imply that elevated HBP-morning in winter reflects the response of BP to cold after getting up.	Creatinine	118-128	heme binding protein 1	Homo sapiens	183-186
32458111-10	2020	ROC curve analysis identified an Angiopoietin-2 cut-off of 5000 pg/mL as the best predictor for ICU outcome (Se = 80.1%, Sp = 70%, PPV = 72.7%, NPV = 77%), further confirmed in multivariate analysis after adjustment for creatinine, CRP or D-dimers.	Creatinine	220-230	angiopoietin 2	Homo sapiens	33-47
32868529-6	2020	Furthermore, cystatin C offers the opportunity to avoid the race coefficient that is required for any current creatinine-based eGFR equation, which has been appropriately criticized for introducing unnecessary imprecision, assumptions and values on GFR estimation.	Creatinine	110-120	cystatin C	Homo sapiens	13-23
32946852-9	2020	Simply linear regression analysis indicated a negative association between serum Metrnl and duration of disease, body mass index (BMI), HbA1c, blood urea nitrogen, creatinine, uricacid, ACR, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers treatment.	Creatinine	164-174	meteorin like, glial cell differentiation regulator	Homo sapiens	81-87
33042337-8	2020	The expression of ERalpha in the glomeruli of IgAN renal tissue decreased gradually (P = 0.001, P < 0.05) with the increasing severity of disease and its expression was associated with estimated glomerular filtration rate (eGFR), serum creatinine (Scr) and pathological grade (r = 0.876, -0.818 and -0.736, P < 0.05).	Creatinine	236-246	IGAN1	Homo sapiens	46-50
32740186-10	2020	In children with sepsis-induced organ dysfunction, angiopoietin-2/-1 ratios correlated with oxygenation indices and serum levels of creatinine and bilirubin.	Creatinine	132-142	angiopoietin 2	Homo sapiens	51-68
32742386-9	2020	Expression of C"s C was positively correlated with urea nitrogen and creatinine (P<0.05).	Creatinine	69-79	cystatin C	Homo sapiens	14-19
32468592-7	2020	Transcript levels of MMP7 (P = .05) and TIMP1 (P = .005) were positively associated with serum creatinine in cats with CKD, but not in control cats.	Creatinine	95-105	matrix metallopeptidase 7	Felis catus	21-25
32601635-8	2020	urinary neutrophil gelatinase-associated lipocalin, urinary N-acetyl-beta-D-glucosaminidase and Cystatin C showed a positive correlation with fasting blood glucose (FBG), HbA1c, duration of diabetes, urea, creatinine, and ACR.	Creatinine	206-216	cystatin C	Homo sapiens	96-106
32150034-11	2020	An estimated glomerular filtration rate by chronic kidney disease (CKD)-EPI-CysC-creatinine <60 mL/min/1.73 m at WL inclusion was an independent predictor of the need for renal replacement therapy (RRT) in the first month post-LT.	Creatinine	81-91	cystatin C	Homo sapiens	76-80
32600320-10	2020	All three LM markers (breath H2, plasma glucose and urinary galactose/creatinine) discriminated between lactase persistence (LP) and LNP following lactose challenge with an area under the receiver operating characteristic (ROC) curve (AUC) of 1.00, 0.75 and 0.73, respectively.	Creatinine	70-80	lactase	Homo sapiens	104-111
32610429-6	2020	In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (p < 0.0001) and pFL-OPN (p < 0.001) were observed.	Creatinine	44-54	cystatin C	Homo sapiens	100-110
32569211-4	2020	Meanwhile, MIR103 and MIR107 were negatively correlated with acute pathologic and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, serum creatinine, C-reactive protein, tumor necrosis factor, interleukin 1beta, interleukin 6 and interleukin 8, while positively correlated with albumin in sepsis patients.	Creatinine	183-193	microRNA 107	Homo sapiens	22-28
32495751-9	2020	Visfatin in the plasma of acute myocardial infarction (AMI) probands, correlated in individuals with acute coronary syndrome was related to plasma glucose (r=0.47; P=0.01), type 2 diabetes mellitus (r=0.65; P=0.01), plasma creatinine concentration (r=0.3, P=0.02), hsCRP (r=0.29; P=0.03), BMI values (r=0.18;P=0.04), triglycerides (r=0.5;P=0.01) and NT-proBNP (r=0.21; P=0.04).	Creatinine	223-233	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
32475043-8	2020	In preterm-born young adults with VLBW, lower urinary alpha-klotho/creatinine was associated with higher SBP, lower urinary Ang-(1-7)/creatinine, and higher urinary Ang II/Ang-(1-7).	Creatinine	67-77	angiopoietin 1	Homo sapiens	124-132
32475043-8	2020	In preterm-born young adults with VLBW, lower urinary alpha-klotho/creatinine was associated with higher SBP, lower urinary Ang-(1-7)/creatinine, and higher urinary Ang II/Ang-(1-7).	Creatinine	67-77	angiopoietin 1	Homo sapiens	172-180
32340426-11	2020	After adjustment for age, sex, fasting plasma glucose and creatinine, cystatin C was positively correlated with the duration of diabetes, systolic blood pressure (SBP), total cholesterol, triglycerides, uric acid and low-density lipoprotein cholesterol (P=0.004, P=0.022, P=0.013, P=0.035, P=0.006, P=0.012, respectively) and negatively correlated with hemoglobin (P<0.001).	Creatinine	58-68	cystatin C	Homo sapiens	70-80
32368256-7	2020	Furthermore, TUG1 expression in SAT positively correlated with BMI, waist circumference (WC), hip circumference, HOMA-IR, and insulin levels, eGFR value, creatinine levels, and hs-CRP in all participants independent of age and HOMA-IR.	Creatinine	154-164	taurine up-regulated 1	Homo sapiens	13-17
31840157-12	2020	There were also correlations of IL-11 with tissue collagen expansion, number of activated fibroblasts and serum creatinine, but no correlation with mean arterial pressure.	Creatinine	112-122	interleukin 11	Rattus norvegicus	32-37
31837940-13	2020	Treatment with PD-1/PD-L1 inhibitors should be prescribed with caution in patients with UC and creatinine above 1.2 mg/dL.	Creatinine	95-105	programmed cell death 1	Homo sapiens	15-19
30309817-8	2020	Based on the evidence reviewed, serum cystatin C and urinary neutrophil gelatinase-associated lipocalin (NGAL) showed a significant correlation with serum creatinine rise postoperatively, emerging as potential noninvasive and early biomarkers of AKI in patients undergoing renal surgery.	Creatinine	155-165	cystatin C	Homo sapiens	38-48
30309817-9	2020	In this setting, serum cystatin C and urinary NGAL have preceded the rise in serum creatinine peak from 3 up to 24h, even in case of mild renal damage.	Creatinine	83-93	cystatin C	Homo sapiens	23-33
31882526-9	2020	Patients with SMA with 4 SMN2 copies had 1.8-fold (95% CI 1.57-2.11; p < 0.0001) higher Crn levels compared to patients with SMA with 2 SMN2 copies and 1.4-fold (95% CI 1.24-1.58; p < 0.0001) higher Crn levels compared to patients with SMA with 3 SMN2 copies.	Creatinine	88-91	survival of motor neuron 2, centromeric	Homo sapiens	25-29
31882526-10	2020	Patients with SMA with 3 SMN2 copies had 1.4-fold (95% CI 1.21-1.56; p < 0.0001) higher Crn levels than patients with SMA with 2 SMN2 copies.	Creatinine	88-91	survival of motor neuron 2, centromeric	Homo sapiens	25-29
31882526-10	2020	Patients with SMA with 3 SMN2 copies had 1.4-fold (95% CI 1.21-1.56; p < 0.0001) higher Crn levels than patients with SMA with 2 SMN2 copies.	Creatinine	88-91	survival of motor neuron 2, centromeric	Homo sapiens	129-133
31606236-9	2020	RESULTS: High levels (>3.9mug/g of creatinine) of urinary MMP-7 were associated with a 2.7-fold higher risk for IgAN progression in adjusted analyses.	Creatinine	35-45	IGAN1	Homo sapiens	112-116
31967348-7	2020	In sepsis patients, miR-125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR-125b was positively associated with Scr, C-reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease.	Creatinine	86-96	microRNA 125a	Homo sapiens	20-28
33447754-8	2020	Creatinine levels correlated positively with MMP-2 in the CKD (r = 0.39, p < 0.05) and negatively in the diabetes group (r = -0.72, p < 0.05).	Creatinine	0-10	matrix metallopeptidase 2	Homo sapiens	45-50
31790283-7	2020	In particular, TLR9 expression in plasma cells correlated with ESR, CRP, serum creatinine, eGFR, and Birmingham Vasculitis Activity Score.	Creatinine	79-89	toll like receptor 9	Homo sapiens	15-19
31857443-3	2020	Important changes include: 1) the decision to treat high-risk individuals with a glucagon-like peptide 1 (GLP-1) receptor agonist or sodium-glucose cotransporter 2 (SGLT2) inhibitor to reduce major adverse cardiovascular events (MACE), hospitalization for heart failure (hHF), cardiovascular death, or chronic kidney disease (CKD) progression should be considered independently of baseline HbA1c or individualized HbA1c target; 2) GLP-1 receptor agonists can also be considered in patients with type 2 diabetes without established cardiovascular disease (CVD) but with the presence of specific indicators of high risk; and 3) SGLT2 inhibitors are recommended in patients with type 2 diabetes and heart failure, particularly those with heart failure with reduced ejection fraction, to reduce hHF, MACE, and CVD death, as well as in patients with type 2 diabetes with CKD (estimated glomerular filtration rate 30 to <=60 mL min-1 [1.73 m]-2 or urinary albumin-to-creatinine ratio >30 mg/g, particularly >300 mg/g) to prevent the progression of CKD, hHF, MACE, and cardiovascular death.	Creatinine	961-971	glucagon like peptide 1 receptor	Homo sapiens	106-121
28411358-7	2020	There were significant positive correlations between serum cystatin C levels and serum creatinine levels and negative correlations with creatinine clearance levels at each time point (P &lt; .001), whereas no statistically significant associations were observed with urinary neutrophil gelatinase-associated lipocalin levels.	Creatinine	87-97	cystatin C	Homo sapiens	59-69
31877497-13	2020	CRNDE knockdown in rats increased the urea nitrogen and serum creatinine in plasma.	Creatinine	62-72	colorectal neoplasia differentially expressed	Rattus norvegicus	0-5
32046440-5	2020	Creatinine-adjusted urinary BPA concentrations were positively correlated with serum MMP2, MMP9 levels, and the risk of peritoneal EMs (third vs lowest quartile: OR 4.92, 95% CI 1.47, 16.50; fourth versus lowest quartile: OR 3.70, 95% CI 1.07, 12.74, Ptrend = 0.030).	Creatinine	0-10	matrix metallopeptidase 2	Homo sapiens	85-89
31755786-1	2020	The link between cystatin C and mortality independent of glomerular filtration rate (GFR) in adults has prompted the "Shrunken Pore Syndrome" (SPS) hypothesis, where high serum cystatin C with normal creatinine is explained by smaller glomerular pores, through which creatinine can pass freely, while the larger cystatin C, beta-trace protein (BTP) and pro-inflammatory molecules are retained.	Creatinine	267-277	cystatin C	Homo sapiens	177-187
31755786-1	2020	The link between cystatin C and mortality independent of glomerular filtration rate (GFR) in adults has prompted the "Shrunken Pore Syndrome" (SPS) hypothesis, where high serum cystatin C with normal creatinine is explained by smaller glomerular pores, through which creatinine can pass freely, while the larger cystatin C, beta-trace protein (BTP) and pro-inflammatory molecules are retained.	Creatinine	267-277	cystatin C	Homo sapiens	177-187
32615578-7	2020	In particular, a low XOR activity with an increased serum creatinine level (>1.21 mg/dL) was independently associated with heart failure events (HR 1.937, 95% CI 1.199-3.130).	Creatinine	58-68	xanthine dehydrogenase	Homo sapiens	21-24
32115608-1	2020	OBJECTIVES: To clarify whether serum creatinine to cystatin C ratio (CCR), a marker of muscle mass and muscle function may be used as a simple marker of bone property.	Creatinine	37-47	cystatin C	Homo sapiens	51-61
31448496-9	2020	RESULTS: Cystatin C and BTP showed excellent correlations with creatinine values at baseline and follow-up.	Creatinine	63-73	cystatin C	Homo sapiens	9-19
31842785-5	2019	RESULTS: The FSGS+ group had a longer disease course, higher blood pressure levels, and higher serum creatinine and beta2-microglobulin levels than did the FSGS- group (all P &lt; 0.05).	Creatinine	101-111	actinin alpha 4	Homo sapiens	13-17
31701661-1	2019	OBJECTIVE: To explore the predictive value of serum creatinine (Cr) to cystatin C (CysC) ratio in neurocritically ill patients.	Creatinine	52-62	cystatin C	Homo sapiens	83-87
31701661-9	2019	In multivariate logistic regression analysis, we identified serum Cr/CysC ratio as an independent predictor of long-term functional outcome (OR: 0.989, 95% CI: 0.980-0.998, p = .015) but not 30-day mortality (p = .513).	Creatinine	66-68	cystatin C	Homo sapiens	69-73
31701661-10	2019	CONCLUSIONS: Serum Cr/CysC ratio at admission could be used as a predictor of long-term poor prognosis in neurocritically ill patients.	Creatinine	19-21	cystatin C	Homo sapiens	22-26
31885559-8	2019	Firstly, in vivo investigation exhibited that elevation of miR-98-5p restrained proteinuria, serum creatinine, BUN, the EMT process, and fibrosis.	Creatinine	99-109	microRNA 98	Mus musculus	59-65
31752725-10	2019	Serum creatinine and BUN levels in MRL/lpr mice was maintained in highest CRIg/FH dose (10 mg/kg twice a week) to be significantly lower than that in prednisone treated MRL/lpr mice at 20 weeks age.	Creatinine	6-16	V-set and immunoglobulin domain containing 4	Mus musculus	74-78
31772686-9	2019	In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients.	Creatinine	106-116	microRNA 143	Homo sapiens	49-56
31439327-6	2019	RESULTS: Blood urea nitrogen and serum creatinine levels were significantly lower in the IR-AAT group than in the IR group.	Creatinine	39-49	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	92-95
31533337-8	2019	Areas under the receiver operating characteristic curve, comparing baseline creatinine, proteinuria, urinary NRP-1, and VEGFA protein levels, showed NRP-1 to be an independent predictor for clinical response.	Creatinine	76-86	neuropilin 1	Homo sapiens	149-154
31128228-8	2019	BNP or Pro-BNP was inversely associated with overall survival (hazard ratio = 2.27; 95% CI, 1.29-3.97) in univariate Cox regression analysis, and remained significant in multivariate Cox regression analysis (hazard ratio = 3.09; 95% CI, 1.40-6.84) after adjusting for treatment group and known prognostic variables such as performance status, albumin, creatinine, delirium, dyspnea, and anorexia.	Creatinine	352-362	natriuretic peptide B	Homo sapiens	0-3
31128228-8	2019	BNP or Pro-BNP was inversely associated with overall survival (hazard ratio = 2.27; 95% CI, 1.29-3.97) in univariate Cox regression analysis, and remained significant in multivariate Cox regression analysis (hazard ratio = 3.09; 95% CI, 1.40-6.84) after adjusting for treatment group and known prognostic variables such as performance status, albumin, creatinine, delirium, dyspnea, and anorexia.	Creatinine	352-362	natriuretic peptide B	Homo sapiens	11-14
8742174-9	1996	Since the technique proved to be able to identify activated eosinophils bearing the CD69 early activation antigen, the relation between serum creatinine and CD69 expression on peripheral blood eosinophils was analysed showing a positive correlation (r = 0.4344, P = 0.016).	Creatinine	142-152	CD69 molecule	Homo sapiens	157-161
8544400-1	1995	Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure.	Creatinine	100-110	fibroblast growth factor 2	Rattus norvegicus	50-55
7667608-4	1995	NAG activity was also elevated (18.9 +/- 20.1 vs. 4.32 +/- 3.33 and 9.99 +/- 9.72 mukat mol creatinine-1, p &lt; 0.001 and p &lt; 0.05, respectively).	Creatinine	92-102	O-GlcNAcase	Homo sapiens	0-3
7762951-3	1995	The upper reference limit for NAG excretion in the control patients was found to be 0.25 U/mmol creatinine but was abnormally raised in 60% of Type I diabetic patients before any increase in AER (greater than 20 micrograms/min), and in 82% of patients with AER greater than 200 micrograms/min.	Creatinine	96-106	O-GlcNAcase	Homo sapiens	30-33
7863465-5	1994	Moreover, the level of RGDS-antigen positively correlated with plasma creatinine concentration (R = 0.87, p &lt; 0.001).	Creatinine	70-80	ral guanine nucleotide dissociation stimulator	Homo sapiens	23-27
8283554-7	1994	The mean bladder urinary NAG levels in patients with ureteropelvic junction obstruction (17.6 units per mg. creatinine, standard error of mean 2.01, p &lt; 0.001) and megaureters (19.2 units per mg. creatinine, standard error of mean 3.6, p &lt; 0.049) were elevated above control patients (10.6 units per mg. creatinine, standard error of mean 1.02).	Creatinine	108-118	O-GlcNAcase	Homo sapiens	25-28
8172477-5	1994	Renal insufficiency was defined by serum creatinine levels of (m +/- SD) 271 +/- 171 mumol/l and a glomerular filtration rate of 36.7 +/- 18.6 ml/min.	Creatinine	41-51	MSD	Homo sapiens	63-71
31438470-8	2019	YKL-40 level was correlated with the length of hospital stay (r = 0.229, p = 0.042), the levels of inflammatory markers-that is, blood leukocytes (r = 0.234, p = 0.040), plasma C-reactive protein (r = 0.332, p = 0.003), and interleukin-6 (r = 0.544, p < 0.001), and maximum plasma creatinine level (r = 0.370, p = 0.001).	Creatinine	281-291	chitinase 3 like 1	Homo sapiens	0-6
31305329-8	2019	Renal biomarkers of urine albumin:creatinine and beta-2-microglobulin:creatinine ratios significantly improved on E/C/F/TAF.	Creatinine	34-44	TATA-box binding protein associated factor 8	Homo sapiens	120-123
31305329-8	2019	Renal biomarkers of urine albumin:creatinine and beta-2-microglobulin:creatinine ratios significantly improved on E/C/F/TAF.	Creatinine	70-80	TATA-box binding protein associated factor 8	Homo sapiens	120-123
31497427-14	2019	Four individuals were positive for anti-proteinase 3 (PR3) antibody, three of whom were strongly positive with renal involvement defined by an elevated creatinine with two having biopsy-proven lupus nephritis.	Creatinine	152-162	proteinase 3	Homo sapiens	35-52
31497427-14	2019	Four individuals were positive for anti-proteinase 3 (PR3) antibody, three of whom were strongly positive with renal involvement defined by an elevated creatinine with two having biopsy-proven lupus nephritis.	Creatinine	152-162	proteinase 3	Homo sapiens	54-57
31230006-14	2019	Total urinary excretion of plasminogen/plasmin was defined by the urine plasminogen-plasmin/creatinine ratio.	Creatinine	92-102	plasminogen	Homo sapiens	27-34
31230006-14	2019	Total urinary excretion of plasminogen/plasmin was defined by the urine plasminogen-plasmin/creatinine ratio.	Creatinine	92-102	plasminogen	Homo sapiens	39-46
31230006-17	2019	RESULTS: The development of PE in late pregnancy was associated with increased levels of the urine plasminogen-plasmin/creatinine ratio (OR=2.35; 95% CI: 1.12 to 4.93; p&lt;0.05).U-aldosterone/creatinine ratio did not predict PE at any time.	Creatinine	119-129	plasminogen	Homo sapiens	99-106
31230006-17	2019	RESULTS: The development of PE in late pregnancy was associated with increased levels of the urine plasminogen-plasmin/creatinine ratio (OR=2.35; 95% CI: 1.12 to 4.93; p&lt;0.05).U-aldosterone/creatinine ratio did not predict PE at any time.	Creatinine	193-203	plasminogen	Homo sapiens	99-106
30889420-1	2019	Urinary beta2-microgroblin (beta2-MG) excretion levels above 300 mug/g creatinine are used to indicate defective tubular reabsorption.	Creatinine	71-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-13
30889420-1	2019	Urinary beta2-microgroblin (beta2-MG) excretion levels above 300 mug/g creatinine are used to indicate defective tubular reabsorption.	Creatinine	71-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-33
30889420-10	2019	Urinary beta2-MG levels &lt;300 mug/g creatinine were associated with 4.66 (95% CI: 1.92, 11.32) fold increase in the POR for low GFR, compared with urinary beta2-MG levels &lt;100 mug/g creatinine.	Creatinine	38-48	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-13
30889420-10	2019	Urinary beta2-MG levels &lt;300 mug/g creatinine were associated with 4.66 (95% CI: 1.92, 11.32) fold increase in the POR for low GFR, compared with urinary beta2-MG levels &lt;100 mug/g creatinine.	Creatinine	187-197	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-13
32658933-6	2020	In addition, the administration of miR-223 over-expressed macrophages with IL-4 pre-conditioning, but not IL-4 stimulated control cells, attenuated sepsis severity in LPS injected mice as evaluated by serum creatinine, liver enzymes, lung histology and serum cytokines.	Creatinine	207-217	microRNA 223	Mus musculus	35-42
32653023-11	2020	CONCLUSIONS: Higher plasma levels of cystatin C on enrollment were strongly associated with mortality at 60 days in patients with ARDS with and without AKI identified by creatinine-based definitions.	Creatinine	170-180	cystatin C	Homo sapiens	37-47
32857720-10	2020	Polymorphic site of CYP11B2 (rs1799998) gene is associated with SBP and DBP increase (p<0.05), reduced GFR preferably calculated by CKDEPI-cystatin C (F=10.79-14.45; p<0.001) and elevated aldosterone content (F=55.84; p<0.001), creatinine and cystatin-S as well (F=4.16-5.08; p<0.05) mainly in the TT-genotype female carriers (p<0.001).	Creatinine	228-238	cystatin S	Homo sapiens	243-253
32322216-4	2020	In humans, uE miR-451 was approximately twofold higher in subjects with early-stage chronic kidney disease (CKD; serum creatinine < 2.0 mg/dl; n = 28), as compared to age-matched healthy controls (n = 23), and had a significant negative correlation with estimated glomerular filtration rate (eGFR) (r 2 = -0.10, p = 0.01).	Creatinine	119-129	microRNA 451a	Homo sapiens	14-21
31926796-11	2020	CONCLUSIONS: The level of plasma cystatin C increased 48 h before both RRI and serum creatinine did in critically ill neonates who developed AKI, so it is more reliable in predicting AKI in critically ill neonates than serum creatinine and RRI.	Creatinine	85-95	cystatin C	Homo sapiens	33-43
31926796-11	2020	CONCLUSIONS: The level of plasma cystatin C increased 48 h before both RRI and serum creatinine did in critically ill neonates who developed AKI, so it is more reliable in predicting AKI in critically ill neonates than serum creatinine and RRI.	Creatinine	225-235	cystatin C	Homo sapiens	33-43
7917182-0	1994	Amperometric flow-injection analysis of creatinine based on immobilized creatinine deiminase, leucine dehydrogenase and L-amino acid oxidase.	Creatinine	40-50	interleukin 4 induced 1	Homo sapiens	120-140
7917182-1	1994	Leucine dehydrogenase/L-amino acid oxidase was proposed as an enzymatic conversion system for ammonia and its application to amperometric assay of creatinine was investigated.	Creatinine	147-157	interleukin 4 induced 1	Homo sapiens	22-42
7917182-2	1994	Ammonia formed by creatinine deiminase catalyzed hydrolysis of creatinine was converted to L-leucine by leucine dehydrogenase, and the oxidation of L-leucine by L-amino acid oxidase was detected with an oxygen electrode.	Creatinine	18-28	interleukin 4 induced 1	Homo sapiens	161-181
7988626-6	1994	Although age, haematocrit, creatinine clearance, serum albumin and cholesterol differed between the two groups, only haematocrit and creatinine clearance were significantly (negatively) correlated with CsA clearance.	Creatinine	133-143	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	202-205
32153399-3	2020	We found that bFGF treatment significantly alleviate urinary albumin to creatinine ratio and renal fibrosis in db/db mice, suggesting a potential renal protective effect.	Creatinine	72-82	fibroblast growth factor 2	Mus musculus	14-18
31734275-5	2020	RESULTS: Smad3 knockout (KO)-db/db mice were protected from the development of diabetic kidney injury, characterized by the normal levels of urinary albumin excretion and serum creatinine without any evidence for renal fibrosis and inflammation.	Creatinine	177-187	SMAD family member 3	Mus musculus	9-14
31734275-6	2020	In contrast, Smad3 wild-type (WT) db/db and Smad3+/- db/db mice developed progressively decline in renal function over the 12 to 32-week time course, including increased microalbuminuria and elevated levels of serum creatinine.	Creatinine	216-226	SMAD family member 3	Mus musculus	13-18
31734275-6	2020	In contrast, Smad3 wild-type (WT) db/db and Smad3+/- db/db mice developed progressively decline in renal function over the 12 to 32-week time course, including increased microalbuminuria and elevated levels of serum creatinine.	Creatinine	216-226	SMAD family member 3	Mus musculus	44-49
31905169-4	2020	The albumin level in urine decreased significantly and the albumin/creatinine ratio decreased slightly in DPP4-def-STZ.	Creatinine	67-77	dipeptidylpeptidase 4	Rattus norvegicus	106-110
8508616-7	1993	In all subjects and in patients, FVIII:C was related to urinary albumin excretion and creatinine clearance.	Creatinine	86-96	coagulation factor VIII	Homo sapiens	33-38
8346988-3	1993	There were direct relationships between serum TCII levels and blood urea-nitrogen or creatinine concentrations.	Creatinine	85-95	transcobalamin 2	Homo sapiens	46-50
1325148-10	1992	In addition, it seems that the variations in S-IL-2R are partly related to renal function itself, as suggested by the correlation between S-IL-2R levels and serum creatinine levels.	Creatinine	163-173	interleukin 2 receptor subunit alpha	Homo sapiens	47-52
31913143-4	2020	METHODS: We report on 7 patients with recurrent FSGS on kidney allograft (proteinuria >=3 g/g of urinary creatinine or >=3 g/day); they all received IA.	Creatinine	105-115	actinin alpha 4	Homo sapiens	48-52
30715595-8	2019	Arithmetic means of the best creatinine and cystatin C equations above improved bias compared to the existing composite creatinine+cystatin C equations.	Creatinine	120-130	cystatin C	Homo sapiens	44-54
31108979-2	2019	The aim of the study was to assess whether tubular creatinine secretion affects Ccr in early stages of BEN and to check the applicability of serum creatinine-based glomerular filtration rate (GFR) equations in these patients.	Creatinine	147-157	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	192-195
31057604-8	2019	Trans-4-hydroxy-L-proline (p = 6 x 10-9), being strongly correlated with plasma creatinine (CREA), showed strongest association with SNPs on chromosome 6 that had pleiotropic effects on PRODH2 expression as revealed by multivariate analysis.	Creatinine	92-96	proline dehydrogenase 2	Sus scrofa	186-192
32734188-5	2019	On admission, serum creatinine level was elevated with increased urinary beta2-microglobulin and N-acetyl-beta-d-glucosaminidase excretion.	Creatinine	20-30	O-GlcNAcase	Homo sapiens	97-128
1325148-10	1992	In addition, it seems that the variations in S-IL-2R are partly related to renal function itself, as suggested by the correlation between S-IL-2R levels and serum creatinine levels.	Creatinine	163-173	interleukin 2 receptor subunit alpha	Homo sapiens	140-145
30949507-8	2019	However, only serum CysC was an independent factor predicting mortality in patients with normal creatinine levels.	Creatinine	96-106	cystatin C	Homo sapiens	20-24
1296433-1	1992	The activity of urinary N-acetyl-beta-glucosaminidase (NAG) was measured in random urines using the ratio (NAG index) of NAG to grams of urine creatinine in 102 epileptic children taking antiepileptic drugs (AEDs).	Creatinine	143-153	O-GlcNAcase	Homo sapiens	24-53
30729090-6	2019	In multiple linear regression analysis, NAG showed a positive significant association with NGAL in the three different adjusted models, while no significant correlation with fasting blood glucose, glycated hemoglobin, serum creatinine, estimated glomerular filtration rate, and albumin creatinine ratio were observed.	Creatinine	286-296	O-GlcNAcase	Homo sapiens	40-43
30304543-8	2019	MiR-101a mimics significantly improved GFR and inhibited AngII-induced increase in the ratio of urine albumin to creatinine, BUN and Scr.	Creatinine	113-123	microRNA 101a	Mus musculus	0-8
1296433-1	1992	The activity of urinary N-acetyl-beta-glucosaminidase (NAG) was measured in random urines using the ratio (NAG index) of NAG to grams of urine creatinine in 102 epileptic children taking antiepileptic drugs (AEDs).	Creatinine	143-153	O-GlcNAcase	Homo sapiens	55-58
1587629-11	1992	The present results indicate the association of urinary Cd and NAG levels in a Cd-exposed population whose geometric mean of urinary Cd content is about 2 micrograms/g creatinine.	Creatinine	168-178	O-GlcNAcase	Homo sapiens	63-66
30617956-10	2019	The positive associations between IS and Cu/Zn SOD, neopterin, hs-CRP, creatinine and neutrophils/lymphocytes ratio were observed in CKD-NONE and CKD-POLI subgroups.	Creatinine	71-81	DNA polymerase iota	Homo sapiens	150-154
18475461-5	1992	On the other hand, the serum concentration of complement protein factor D and soluble IL-2 receptor showed a good correlation to s-creatinine, r = 0.92 and 0.79, respectively.	Creatinine	131-141	interleukin 2 receptor subunit beta	Homo sapiens	86-99
30387865-8	2019	Urinary N-acetyl-beta-D-glucosaminidase decreased in both sirolimus and everolimus groups at 6 months (-68.7 +- 137.6 and -62.0 +- 92.4 U/g creatinine, both P < .05), and the reduction of urinary neutrophil gelatinase-associated lipocalin was significant in the sirolimus group (-4345.1 +- 7763.5 ng/g creatinine; P < .05).	Creatinine	140-150	O-GlcNAcase	Homo sapiens	8-39
32448110-7	2020	Principally, pellet urinary megalin associated positively (p < 0.05) with vitamin D hypovitaminosis and the albumin-to-creatinine ratio (ACR) but negatively (p < 0.05) with Ca2+ and body mass index (BMI).	Creatinine	119-129	LDL receptor related protein 2	Homo sapiens	28-35
32050196-10	2020	The regression lines" slope of serum cystatin C against creatinine and cystatin C-based eGFR against creatinine-based eGFR, between G and A allele groups, showed a statistically significant difference (z-score = 3.457, p &lt; 0.001 and z-score = 2.158, p = 0.015, respectively).	Creatinine	56-66	cystatin C	Homo sapiens	37-47
32050196-10	2020	The regression lines" slope of serum cystatin C against creatinine and cystatin C-based eGFR against creatinine-based eGFR, between G and A allele groups, showed a statistically significant difference (z-score = 3.457, p &lt; 0.001 and z-score = 2.158, p = 0.015, respectively).	Creatinine	101-111	cystatin C	Homo sapiens	37-47
32050196-10	2020	The regression lines" slope of serum cystatin C against creatinine and cystatin C-based eGFR against creatinine-based eGFR, between G and A allele groups, showed a statistically significant difference (z-score = 3.457, p &lt; 0.001 and z-score = 2.158, p = 0.015, respectively).	Creatinine	101-111	cystatin C	Homo sapiens	71-81
32050196-11	2020	Patients with A allele had a lower serum cystatin C level when the values were extrapolated at a fixed serum creatinine value, suggesting the influence of genetic factor.	Creatinine	109-119	cystatin C	Homo sapiens	41-51
31902889-1	2020	We previously reported the association of the estimated glomerular filtration rate (eGFRcreat) calculated from the serum creatinine level (S-Cr) measured using the Jaffe method with the GFR (eGFRcys) estimated from the serum cystatin C level (CysC).	Creatinine	121-131	cystatin C	Homo sapiens	225-235
31455680-4	2019	RESULTS: In PPK analysis, older age, Bev/Cyclo regimen, and higher creatinine were associated with decreased sorafenib apparent clearance (CL/f) (P &lt; 0.0001 for all) and concurrent Clo/AraC administration was associated with decreased sorafenib N-oxide CL/f (P = 7e-4).	Creatinine	67-77	exosome component 2	Homo sapiens	262-270
31801580-8	2019	Joint utilization of C1q and CysC achieved very good performance (AUC = 0.933) which approximated to the best one observed in the combinations of C1q, Urea, CysC, eGFRCreat, and Creat (AUC = 0.975).	Creatinine	167-172	cystatin C	Homo sapiens	29-33
31196770-7	2019	Patients with a UTI had lower renal function (higher blood urea nitrogen [P = 0.001], higher creatinine [P = 0.001]), lower systolic blood pressure (P = 0.04), higher A-DROP scores (P = 0.005) and higher positive blood culture rates (P = 0.03) than those without a UTI.	Creatinine	93-103	alpha-1-microglobulin/bikunin precursor	Homo sapiens	16-19
1313986-7	1992	The results demonstrated that the serum creatinine (Scr) and renal MDA content in the CGRP group were significantly lower than those in the control group.	Creatinine	40-50	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
31302329-11	2019	The injection of miR-187 agomir not only effectively protected the kidney from I/R-induced injury, but also reduced the concentrations of serum creatinine.	Creatinine	144-154	microRNA 187	Mus musculus	17-24
31434620-2	2019	METHODS: PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urinary albumin creatinine ratio (ACR) >=300 mg/g), or chronic kidney disease (CKD) stages 3 (eGFR<60 ml/min) or 4 (eGFR<60 and <30 ml/min respectively).	Creatinine	140-150	serpin family F member 1	Homo sapiens	9-13
31434620-6	2019	Lower eGFR (p < 0.01), higher serum creatinine (p < 0.01) and urinary ACR (p < 0.01) were associated with increasing PEDF.	Creatinine	36-46	serpin family F member 1	Homo sapiens	117-121
31642444-2	2019	ARC is considered when the creatinine clearance rate exceeds 130 mL/(min 1.73 m2).	Creatinine	27-37	activity regulated cytoskeleton associated protein	Homo sapiens	0-3
31228616-6	2019	Compared to wild type (WT) littermates, endothelial conditional BRG1 knockout (CKO) mice were protected from ischemia-reperfusion induced AKI as evidenced by decreased plasma creatinine levels, attenuated caste and tubular necrosis, and diminished immune infiltrates.	Creatinine	175-185	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	64-68
30723936-1	2019	Augmented renal clearance (ARC) is a phenomenon in critically ill patients characterized by increased creatinine clearance and elimination of renally eliminated medications.	Creatinine	102-112	activity regulated cytoskeleton associated protein	Homo sapiens	27-30
30723936-2	2019	Patients with severe neurologic injury, sepsis, trauma, and burns have been consistently identified as at risk of ARC, with mean creatinine clearances ranging from 170 ml/minute to more than 300 ml/minute.	Creatinine	129-139	activity regulated cytoskeleton associated protein	Homo sapiens	114-117
30654738-9	2019	RESULTS: For all DAP metabolites, the creatinine-adjusted single ICCs exceeded 0.4, indicating moderate reliability.	Creatinine	38-48	death associated protein	Homo sapiens	17-20
31582658-3	2019	In the present study, we investigated the acute and direct effect of SGLT2 inhibition on creatinine clearance, an index of whole-kidney glomerular filtration rate (GFR), in a rat model of type 2 diabetes.	Creatinine	89-99	solute carrier family 5 member 2	Rattus norvegicus	69-74
30077507-5	2019	We examined possible relationships of cystatin C with blood natriuretic peptide and creatinine levels along with cardiac echocardiography findings.	Creatinine	84-94	cystatin C	Homo sapiens	38-48
30586026-9	2019	Our study showed that patients with elevated BNP were more likely to have an elevation in admission and discharge NIHSS, serum creatinine, left atrial size, and blood glucose (P&lt;0.05).	Creatinine	127-137	natriuretic peptide B	Homo sapiens	45-48
30693082-9	2019	Cox regression revealed that only a decrease in renal function, particularly elevated serum creatinine (AHR=8.848, 95% CI: 1.616-67.437), was associated with a statistically significant increase of in-hospital mortality.	Creatinine	92-102	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
30693082-9	2019	Cox regression revealed that only a decrease in renal function, particularly elevated serum creatinine (AHR=8.848, 95% CI: 1.616-67.437), was associated with a statistically significant increase of in-hospital mortality.	Creatinine	92-102	aryl hydrocarbon receptor	Homo sapiens	104-107
30485081-1	2018	In the presence of 1 equiv of tBuNC, the homolytic cleavage of the FeIII-H bond in the diiron terminal hydride complex [Cp*Fe( t-H)(mu-eta2:eta4-bdt)FeCp*][BF4] (1[BF4]) smoothly took place to release 1/2 H2, followed by binding of a tBuNC group to the unsaturated FeII center.	Creatinine	103-110	DNA polymerase iota	Homo sapiens	135-139
1626452-1	1992	Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine.	Creatinine	126-136	O-GlcNAcase	Homo sapiens	21-50
30993817-2	2019	Cystatin C has been the recent focus of research as a replacement biomarker for creatinine.	Creatinine	80-90	cystatin C	Homo sapiens	0-10
30993817-14	2019	While larger studies are necessary, cystatin C is a promising biomarker to replace creatinine and better estimate kidney function in this population.	Creatinine	83-93	cystatin C	Homo sapiens	36-46
31539141-10	2019	Compared with controls, DM rats presented higher levels of kidney weight, 24 h-urine protein, blood urea nitrogen and serum creatinine, which were markedly reduced after TUG1 overexpression in vivo.	Creatinine	124-134	taurine up-regulated 1	Rattus norvegicus	170-174
31418698-6	2019	National and international recommendations suggest using a cystatin C-based GFR estimate as a confirmatory test in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine.	Creatinine	168-178	cystatin C	Homo sapiens	59-69
31418698-6	2019	National and international recommendations suggest using a cystatin C-based GFR estimate as a confirmatory test in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine.	Creatinine	244-254	cystatin C	Homo sapiens	59-69
31162203-12	2019	In contrast, a second high mobility group box 1 protein wave peaking 3-6 hours after trauma in the most severely injured and physiologically deranged patients was consistently the most important predictor of outcome in our multivariable models, rendering all other predictor variables insignificant except for smaller contributions from age and sex, and of admission base excess for maximal creatinine concentration.	Creatinine	391-401	high mobility group box 1	Homo sapiens	22-47
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 47 member 2	Homo sapiens	253-260
30938057-7	2019	Serum HMGB1 in LN patients correlated positively to the SLE Disease Activity Index (P < 0.0001), and 24 hours urinary proteins and negatively to creatinine clearance (P < 0.001).	Creatinine	145-155	high mobility group box 1	Homo sapiens	6-11
31033142-7	2019	Estimated glomerular filtration rate (eGFR) was obtained using the CKD Epidemiology Collaboration Creatinine-Cystatin C equation, and CKD was defined as eGFR < 60 ml/min/1.73 m2 .	Creatinine	98-108	cystatin C	Homo sapiens	109-119
31060002-7	2019	RESULTS: In the in vivo animal tests, RLX administration prevented increased plasma creatinine and nitrogen levels caused by aristolochic acid as well as alleviated the severity of renal ultrastructural lesions induced by aristolochic acid.	Creatinine	84-94	relaxin 1	Mus musculus	38-41
31075232-9	2019	KEY FINDINGS: ETaR siRNA treatment reduced the levels of serum creatinine and urea nitrogen, decreased the number of apoptotic cells, and ameliorated histological damage after IRI.	Creatinine	63-73	endothelin receptor type A	Homo sapiens	14-18
31186034-10	2019	The mean optical density of NOD2 in glomeruli was significantly higher in crescentic class than non-crescentic class, and correlated with levels of proteinuria and serum creatinine at renal biopsy.	Creatinine	170-180	nucleotide binding oligomerization domain containing 2	Homo sapiens	28-32
1626452-1	1992	Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine.	Creatinine	126-136	O-GlcNAcase	Homo sapiens	52-55
1626452-6	1992	Urinary NAG was markedly elevated during acute azotemic stage, remained at high level (p greater than 0.05) after serum creatinine returning to normal, and even continued to be abnormal several weeks after clinical recovery.	Creatinine	120-130	O-GlcNAcase	Homo sapiens	8-11
1868921-11	1991	The difference between CCr and CIn indicates that 40% of urinary creatinine is of tubular origin.	Creatinine	65-75	pyridoxal phosphatase	Homo sapiens	31-34
2003033-3	1991	NAG activity was factored by the creatinine concentration to given an index.	Creatinine	33-43	O-GlcNAcase	Homo sapiens	0-3
1867887-2	1991	The obtained activities were referred to the creatinine concentrations of the urine samples and given as NAG index.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	105-108
2002625-5	1991	Shock plus myoglobin, but neither one alone, induced substantial S1/S2 proximal tubular morphologic damage and a severe reduction in creatinine clearance, confirming synergistic injury.	Creatinine	133-143	myoglobin	Rattus norvegicus	11-20
30979455-4	2019	RESULTS: The miR-142-5p, miR-142-3p, and miR-223 were significantly upregulated and miR-10b was significantly downregulated in recipients with abnormal levels of serum creatinine 3 to 4 weeks after initial sample collection.	Creatinine	168-178	microRNA 223	Homo sapiens	41-48
30387162-7	2019	TLR2-deficient mice exacerbated renal injury in cisplatin-induced AKI, with higher serum creatinine and blood urea nitrogen, more severe morphological injury compared with that of wild-type mice.	Creatinine	89-99	toll-like receptor 2	Mus musculus	0-4
30387865-8	2019	Urinary N-acetyl-beta-D-glucosaminidase decreased in both sirolimus and everolimus groups at 6 months (-68.7 +- 137.6 and -62.0 +- 92.4 U/g creatinine, both P < .05), and the reduction of urinary neutrophil gelatinase-associated lipocalin was significant in the sirolimus group (-4345.1 +- 7763.5 ng/g creatinine; P < .05).	Creatinine	302-312	O-GlcNAcase	Homo sapiens	8-39
30890820-11	2019	Serum Cystatin-C displayed a significant positive correlation and estimated glomerular filtration rate based on Cystatin-C negative correlation with the rising blood pressure values (p=0.0001).Serum Cystatin-C reflected a very high sensitivity and specificity at a cutoff value of 0.77 mg/l compared to serum creatinine.	Creatinine	309-319	cystatin C	Homo sapiens	6-16
30391334-2	2018	The serum creatinine to cystatin C (Cr/CysC) ratio has been reported as a surrogate marker for muscle mass.	Creatinine	10-20	cystatin C	Homo sapiens	24-34
30376802-7	2018	CONCLUSION: Elevated levels of OPG in patients with diabetic foot may display the severity of the clinical status due to its positive correlation with CRP and creatinine.	Creatinine	159-169	TNF receptor superfamily member 11b	Homo sapiens	31-34
1962476-4	1991	Increased beta-NAG activities above 10 U/g creatinine were associated with a marked increase of creatinine serum levels within 6 months in both, patients with glomerular and tubulointerstitial basic renal diseases.	Creatinine	43-53	O-GlcNAcase	Homo sapiens	10-18
30584402-7	2018	There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p&lt;0.01 respectively).	Creatinine	75-85	cystatin C	Homo sapiens	47-51
30215792-11	2018	The magnitude of increase in FABP4 urinary levels in response to NPAA and puromycin was higher than for established preclinical biomarkers serum creatinine, clusterin, or cystatin C.	Creatinine	145-155	fatty acid binding protein 4	Rattus norvegicus	29-34
30369398-10	2019	Patients with CKD and first-degree relatives with and without (APOL1) risk alleles had statistically indistinguishable blood pressures, creatinine and HDL-cholesterol levels.	Creatinine	136-146	apolipoprotein L1	Homo sapiens	63-68
29968538-8	2019	There was significant association of galectin-3 levels with age (r=0.48, p=0.003), creatinine clearance (r=-0.66, p&lt;0.001) and BNP levels (r=0.36, p=0.05).	Creatinine	83-93	galectin 3	Homo sapiens	37-47
30058208-3	2019	GLP-1 RAs marginally reduced urinary albumin-to-creatinine ratio compared with placebo or other antidiabetic agents (weighted mean difference - 2.55 mg/g; 95% confidence interval [CI] -4.37 to -0.73 and -5.52; -10.89 to -0.16, respectively) and had no clinically relevant effect on change in estimated glomerular filtration rate.	Creatinine	48-58	glucagon like peptide 1 receptor	Homo sapiens	0-5
31458244-6	2018	Our results support a dissociation mechanism proceeding via the formation of a hydride/hydroxyl CeH/OH intermediate.	Creatinine	79-86	epoxide hydrolase 2	Homo sapiens	96-99
1962476-4	1991	Increased beta-NAG activities above 10 U/g creatinine were associated with a marked increase of creatinine serum levels within 6 months in both, patients with glomerular and tubulointerstitial basic renal diseases.	Creatinine	96-106	O-GlcNAcase	Homo sapiens	10-18
1698438-5	1990	Coefficients of log-transformed data with creatinine-derived glomerular filtration rate (GFR) were -0.87 for B2M, -0.71 for RBP, and -0.62 for A1M.	Creatinine	42-52	alpha-1-microglobulin/bikunin precursor	Homo sapiens	143-146
2382679-5	1990	While we found a significant positive correlation of serum soluble IL-2R to BUN and creatinine, we also found a significant negative correlation between serum soluble IL-2R and creatinine clearance.	Creatinine	84-94	interleukin 2 receptor subunit alpha	Homo sapiens	67-72
2382679-5	1990	While we found a significant positive correlation of serum soluble IL-2R to BUN and creatinine, we also found a significant negative correlation between serum soluble IL-2R and creatinine clearance.	Creatinine	177-187	interleukin 2 receptor subunit alpha	Homo sapiens	167-172
24817138-8	2015	Renal ischemia increased phosphorylation of ERK 1/2 and NF-kappaB proteins as early as at 6 h. There was a significant increase in AGT and Ang II levels at 24 and 48 h. Prior saline loading prevented the increase in serum creatinine at 48 h (5.36 +- 1.26 vs. 3.38 +- 1.74 mg/dL, p &lt; 0.05), and suppressed the increases in renal (P)RR, AGT and Ang II contents.	Creatinine	222-232	mitogen activated protein kinase 3	Rattus norvegicus	44-51
34839787-7	2021	A protective role of Hsp22 against LPS-induced myocardial injury emerged, as evidenced from decreased levels of creatinine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and enhanced cardiac function.	Creatinine	112-122	heat shock protein 8	Mus musculus	21-26
34302440-1	2021	BACKGROUND: Creatinine-to-cystatin C ratio has attracted substantial interest as a measure to reflect health wellbeing, but no studies have assessed whether its longitudinal changes are associated with risk of diabetes.	Creatinine	12-22	cystatin C	Homo sapiens	26-36
34302440-8	2021	The multivariable-adjusted OR for diabetes per 1 standard deviation increases in creatinine-to-cystatin C ratio was 0.84 (95% CI 0.72 to 0.98).	Creatinine	81-91	cystatin C	Homo sapiens	95-105
34302440-9	2021	Compared with participants showing decreases in creatinine-to-cystatin C ratio but increases in body mass index (BMI), those experiencing increases in creatinine-to-cystatin C ratio and decreases in BMI had the largest risk reduction (multivariable-adjusted OR 0.52).	Creatinine	151-161	cystatin C	Homo sapiens	165-175
34302440-12	2021	CONCLUSIONS: Increases in creatinine-to-cystatin C ratio led to reduced risk of diabetes and may benefit cardiometabolic control.	Creatinine	26-36	cystatin C	Homo sapiens	40-50
34872988-9	2021	Moreover, NEU1 expression was significantly correlated with serum creatinine value, eGFR and CI scores, respectively.	Creatinine	66-76	neuraminidase 1	Homo sapiens	10-14
34593906-6	2021	GWAS of a PC derived from glomerular filtration rate, serum creatinine, and serum urea identified a suggestive peak (pmin = 1.67 x 10-7) that mapped to KCNIP4.	Creatinine	60-70	potassium voltage-gated channel interacting protein 4	Homo sapiens	152-158
34585312-8	2022	Serum CFB levels correlated positively with serum creatinine levels, anti-PLA2R antibody levels and 24 h urinary protein excretion (P < .05).	Creatinine	50-60	complement factor B	Homo sapiens	6-9
34585312-11	2022	CONCLUSION: High serum CFB levels correlated with increased serum creatinine, anti-PLA2R antibody and urinary protein excretion as well as poor renal prognosis in patients with IMN-IgAN, indicating that serum CFB may be a marker of disease activity and progression.	Creatinine	66-76	complement factor B	Homo sapiens	23-26
34254743-3	2021	According to fundamental transport physiological principles, a thicker GBM will impede the diffusion of middle-molecules such as cystatin C, potentially leading to a lower estimated GFR (eGFR) from cystatin C compared to that of creatinine.	Creatinine	229-239	cystatin C	Homo sapiens	129-139
34345408-1	2021	In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors.	Creatinine	89-99	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	59-62
34345408-4	2021	The purpose of this review is to highlight clinical scenarios and conditions such as extreme body composition, Black race, disagreement between creatinine- and cystatin C-based estimated GFR (eGFR), drug dosing, liver cirrhosis, advanced chronic kidney disease and the transition to kidney replacement therapy, non-kidney solid organ transplant recipients and living kidney donors where creatinine-based GFR estimation may be invalid.	Creatinine	387-397	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	404-407
34749369-7	2021	TG patients with FSGS had higher proteinuria (median, 2.6 vs. 0.8 g/24 h, p < 0.001) and serum creatinine levels (median, 2.5 vs. 2.1 mg/dL, p = 0.04), lower serum albumin levels, higher chronic glomerulopathy (cg) score, larger glomerular tuft area, lower number of podocytes, and higher incidences of podocyte hyperplasia, pseudotubule formation, and diffuse foot process effacement than those without FSGS (all p < 0.05).	Creatinine	95-105	actinin alpha 4	Homo sapiens	17-21
34644709-12	2021	Pearson correlation analysis indicated that serum adropin was negatively correlated with BMI, FBS, HbA1c, blood urea, creatinine, LDL, and ACR and positively correlated with HDL and albumin.	Creatinine	118-128	energy homeostasis associated	Homo sapiens	50-57
35533540-0	2022	Association between muscle mass evaluated by computed tomography and the serum creatinine-cystatin C ratio in children with cancer: A cross-sectional study.	Creatinine	79-89	cystatin C	Homo sapiens	90-100
30345748-5	2018	The PTP chalcone has originally exhibited ICT mechanism and it is arrested while creatinine is added.	Creatinine	81-91	protein tyrosine phosphatase receptor type U	Homo sapiens	4-7
30487748-9	2018	Analysis of primary outcomes showed that patients carrying MTOR c.1437CC and FOXP3 c.-23+2882CC genotypes had higher serum creatinine than non-carriers (p &lt; 0.05) at 1-year post-transplant.	Creatinine	123-133	forkhead box P3	Homo sapiens	77-82
30099048-5	2018	After adjustment for age and gender, Sestrin2 level had a positive relationship with serum triglyceride, alanine aminotransferase (ALT), and creatinine levels, but no association with carotid atherosclerosis.	Creatinine	141-151	sestrin 2	Homo sapiens	37-45
30062791-6	2019	Only urine NAG levels were significantly higher in patients with ATN than those with PRA or HRS (116.1 +- 46.8 U/g vs 39.4 +- 20.2 or 54.0 +- 19.2 U/g urinary creatinine, all P &lt; 0.05).	Creatinine	159-169	O-GlcNAcase	Homo sapiens	11-14
30394304-4	2019	N-acetyl-beta-D-glucosaminidase was detected with high sensitivity and specificity at the early stage of renal injury (Area under the ROC cure (AUC) = 0.929, 95%CI: 0.722-0.995, P &lt; 0.05 vs. serum creatinine and blood urea nitrogen).	Creatinine	200-210	O-GlcNAcase	Homo sapiens	0-31
35533540-2	2022	The aim of this study was to investigate the association between muscle mass evaluated by computed tomography (CT) and the serum creatinine-cystatin C ratio (CCR) in children and adolescents with cancer.	Creatinine	129-139	cystatin C	Homo sapiens	140-150
35621133-6	2022	RESULTS: Serum leptin concentrations were positively correlated with systolic arterial blood pressure (r = .41), creatinine concentrations (r = .39), and symmetric dimethylarginine concentrations (r = .73).	Creatinine	113-123	leptin	Canis lupus familiaris	15-21
30427197-1	2018	A new type of uranium binary hydride, UH2, with the CaF2 crystal structure, was synthesized in a thin-film form using reactive sputter deposition at low temperatures.	Creatinine	29-36	CCR4-NOT transcription complex subunit 8	Homo sapiens	52-56
30132346-7	2018	After 6 mo of hyperglycemia, diabetic Diaph1-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.	Creatinine	182-192	diaphanous related formin 1	Mus musculus	38-44
30219682-5	2018	We found that Lcn2 deficiency significantly aggravated renal injury as evidenced by higher serum creatinine, more severe morphological injury, and increased tubular epithelial cell death in mice.	Creatinine	97-107	lipocalin 2	Mus musculus	14-18
30376802-6	2018	There were positive correlations between OPG levels and C-reactive protein (CRP) and creatinine levels in patients with diabetic foot.	Creatinine	85-95	TNF receptor superfamily member 11b	Homo sapiens	41-44
30532765-6	2018	We observed that FGF10 efficiently reduced I/R-induced elevation in blood urea nitrogen, serum creatinine as well as apoptosis induction of RTCs.	Creatinine	95-105	fibroblast growth factor 10	Rattus norvegicus	17-22
29307766-9	2018	For methamphetamine-positive patients with abnormal BNP, creatinine was significantly higher, but not Troponin I. Logistic regression analysis revealed predictors of abnormal BNP and LVEF &lt;30% in methamphetamine-positive patients, which included age, race, smoking history, elevated creatinine, and respiratory rate.	Creatinine	57-67	natriuretic peptide B	Homo sapiens	175-178
29524314-8	2018	Using linear regression, a higher creatinine level was found to predict both higher levels of NT-proBNP and Sema4D (P = 0.05 and P &lt; 0.014, respectively), while a reduced ejection fraction was found to predict higher NT-proBNP levels only (P &lt; 0.001 and P = 0.87, respectively).	Creatinine	34-44	semaphorin 4D	Homo sapiens	108-114
29683855-9	2018	Mean decrease in urine protein/creatinine ratio was greater with D/C/F/TAF than control (-22.42 vs. -10.34 mg/g, P = 0.033).	Creatinine	31-41	TATA-box binding protein associated factor 8	Homo sapiens	71-74
30143492-3	2018	Cystatin C, a 13 kDA molecular mass protein ubiquitously expressed by nucleated cells, offers superior accuracy in the setting of an urinoma, since unlike creatinine, it is essentially absent in excreted urine and poorly reabsorbed from the peritoneum and retroperitoneal space.	Creatinine	155-165	cystatin C	Homo sapiens	0-10
29040701-10	2018	The addition of cystatin C improved all of the creatinine-based equations.	Creatinine	47-57	cystatin C	Homo sapiens	16-26
30030497-5	2018	Using a mouse model of angiotensin II (Ang II)-induced renal damage, we demonstrate that PI3Kgamma inhibitor AS605240 effectively mitigates Ang II-induced increases in serum creatinine and blood urea nitrogen, renal interstitial collagen deposition, the accumulation of ECM proteins and the expression of alpha-Sma and fibrosis-related genes in vivo.	Creatinine	174-184	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	89-98
29858267-7	2018	Patients with D-ATIN/TINU carrying HLA-DQA1*0104/DQB1*0503/DRB1*1405 had higher peak serum creatinine and more severe renal tubulointerstitial inflammatory impairment.	Creatinine	91-101	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	35-43
35608201-8	2022	Immediately after the marathon, individual relative changes in plasma XOR activity were independently correlated with corresponding changes in serum creatinine and urinary L-FABP levels.	Creatinine	149-159	xanthine dehydrogenase	Homo sapiens	70-73
29688533-13	2018	Use of cystatin C may enable better understanding of plasma creatinine fluctuations after dolutegravir initiation, particularly in high-risk renal patients.	Creatinine	60-70	cystatin C	Homo sapiens	7-17
29690949-9	2018	Serum concentration of creatinine increased in broilers fed LME diets either supplemented with 1 2 g/kg GAA or without GAA supplementation (P&lt;0 05).	Creatinine	23-33	alpha glucosidase 2	Gallus gallus	104-107
29690949-9	2018	Serum concentration of creatinine increased in broilers fed LME diets either supplemented with 1 2 g/kg GAA or without GAA supplementation (P&lt;0 05).	Creatinine	23-33	alpha glucosidase 2	Gallus gallus	119-122
29872039-7	2018	As with angiopoietin-2, osteoprotegerin was increased in proportion to disease severity, and independently associated with severity markers including creatinine, lactate, interleukin-6, endothelial cell adhesion molecules ICAM-1 and E-selectin, and impaired microvascular reactivity.	Creatinine	150-160	TNF receptor superfamily member 11b	Homo sapiens	24-39
29132705-9	2018	The blockage of COX-2 by celecoxib reversed the benefit of IL-pretreated 17A-MSCs on the serum PGE2 concentration, spleen and kidney Tregs percentages, serum creatinine and BUN levels, renal acute tubular necrosis scores, and serum IL-6, TNF-alpha, IFN-gamma, and IL-10 levels of IRI-pretreated mice with AKI, compared with MSCs.	Creatinine	158-168	cytochrome c oxidase II, mitochondrial	Mus musculus	16-21
35183688-9	2022	Furthermore, the variant rs751141, which was linked with a lower hydrolase activity of sEH, was significantly associated with metabolic traits, including blood levels of triglycerides, creatinine, and urate.	Creatinine	185-195	epoxide hydrolase 2	Homo sapiens	87-90
35133981-3	2022	Here, mice with PKM2-specific overexpression in podocytes (PPKM2Tg) were generated to uncover its renal protective function as potential therapeutic target, which prevented elevated albumin-creatinine ratio (ACR), mesangial expansion, basement membrane thickness and podocyte foot process effacement after 7-months of STZ-induced diabetes.	Creatinine	190-200	pyruvate kinase, muscle	Mus musculus	16-20
35363362-11	2022	CONCLUSIONS: There is a direct relationship between circulating amounts of asprosin, visfatin, and subfatin hormones and age, weight, height, diastolic blood pressure, high-density lipoprotein-cholesterol, aspartate aminotransferase, alanine transaminase, and creatinine.	Creatinine	260-270	meteorin like, glial cell differentiation regulator	Homo sapiens	99-107
29513723-2	2018	The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level.	Creatinine	122-132	cystatin C	Homo sapiens	19-29
29331592-0	2018	Combined creatinine-cystatin C CKD-EPI equation significantly underestimates measured glomerular filtration rate in people with type 2 diabetes mellitus.	Creatinine	9-19	cystatin C	Homo sapiens	20-30
29211055-7	2018	A cutoff value of 6.5 pmol/nmol of urinary C-megalin/Cr yielded 73.9% of specificity and 92.9% of sensitivity.ConclusionUrinary C-megalin is useful for diagnosing renal scarring caused by fUTI.	Creatinine	53-55	LDL receptor related protein 2	Homo sapiens	130-137
29579819-3	2018	The aim of this work was to confirm the highest correlation of the GFR as measured with the use of DTPA-Tc99m with the GFR as estimated by means of the formula based on serum cystatin C (CKD-EPI creatinine-cystatin C) in healthy kidney donors.	Creatinine	195-205	cystatin C	Homo sapiens	175-185
29579819-7	2018	Linear correlation with serum cystatin C was 0.825 (P &lt; .001; 95% confidence interval, -105.3 to -63.2) for the CKD-EPI cystatin C formula, 0.77 (P &lt; .001; -89.9 to -48.1) for the CKD-EPI creatinine-cystatin formula, and 0.525 (P = .002; -91.1 to -23.2) for DTPA-Tc99m scintigraphy.	Creatinine	194-204	cystatin C	Homo sapiens	30-40
29579819-7	2018	Linear correlation with serum cystatin C was 0.825 (P &lt; .001; 95% confidence interval, -105.3 to -63.2) for the CKD-EPI cystatin C formula, 0.77 (P &lt; .001; -89.9 to -48.1) for the CKD-EPI creatinine-cystatin formula, and 0.525 (P = .002; -91.1 to -23.2) for DTPA-Tc99m scintigraphy.	Creatinine	194-204	cystatin C	Homo sapiens	123-133
29394255-17	2018	CONCLUSIONS: In this study, the predicting ability of eGFR was improved after the addition of serum cystatin C compared to serum creatinine alone.	Creatinine	129-139	cystatin C	Homo sapiens	100-110
27764902-6	2018	Area under the ROC curve of N-acetyl-beta-glucosaminidase/creatinine ratio (NAG/C) were significantly higher than proteinuria/24 h (0.770 and 0.637 respectively, P = 0.018).	Creatinine	58-68	O-GlcNAcase	Homo sapiens	28-57
29621665-5	2018	RYR1 mutation increased serum creatinine, creatine kinase and CRP and decreased GPx.	Creatinine	30-40	ryanodine receptor 1	Sus scrofa	0-4
29536424-14	2018	The study clearly evaluates the role of serum cystatin C as a good competitor of creatinine among the elderly CKD patients.	Creatinine	81-91	cystatin C	Homo sapiens	46-56
35179040-7	2022	Over 16 years, the association of baseline cystatin C with coronary heart disease, cardiovascular, and all-cause mortality persisted (each P<0.001) and remained significant after adjustment for estimated GFR-creatinine-cystatin C.	Creatinine	208-218	cystatin C	Homo sapiens	43-53
35179040-7	2022	Over 16 years, the association of baseline cystatin C with coronary heart disease, cardiovascular, and all-cause mortality persisted (each P<0.001) and remained significant after adjustment for estimated GFR-creatinine-cystatin C.	Creatinine	208-218	cystatin C	Homo sapiens	219-229
35179040-9	2022	However, this association was no longer significant after adjustment for estimated GFR-creatinine-cystatin C.	Creatinine	87-97	cystatin C	Homo sapiens	98-108
35284461-2	2022	The product of serum creatinine and the estimated glomerular filtration rate based on cystatin C (CrxeGFRcys) was recently proposed as a sarcopenia index (SI), approximately to 24-h filtered creatinine through the glomerulus.	Creatinine	21-31	cystatin C	Homo sapiens	86-96
35100591-6	2022	The association between APOL1 and biomarkers were assessed using regression models adjusting for age, sex, ancestry, hypertension, lipid medications, albumin-to-creatinine ratio, and estimated glomerular filtration rate (eGFR).	Creatinine	161-171	apolipoprotein L1	Homo sapiens	24-29
35139514-7	2022	Spearman correlation analysis of related indicators revealed that serum Cys-C was positively correlated with creatinine, uric acid, and FAZ circularity (P<0.05).	Creatinine	109-119	cystatin C	Homo sapiens	72-77
29880386-7	2018	On day 7, IP-10 expression and CD3-positive T cells were increased in allografts compared with control samples, which were inhibited by the IP-10 antibody treatment accompanied by reduced serum creatinine.	Creatinine	194-204	C-X-C motif chemokine ligand 10	Rattus norvegicus	10-15
29880386-7	2018	On day 7, IP-10 expression and CD3-positive T cells were increased in allografts compared with control samples, which were inhibited by the IP-10 antibody treatment accompanied by reduced serum creatinine.	Creatinine	194-204	C-X-C motif chemokine ligand 10	Rattus norvegicus	140-145
29702981-6	2018	LOX-1 levels were correlated with the levels of uric acid (UA) (r = 0.289, P = .007), creatinine (CREA) (r = .316, P = .003), and high-density lipoprotein cholesterol (HDL-C) (r = -0.271, P = .012), whereas no statistically significant correlation was detected with the Gensini score (r = 0.157, P = .141).	Creatinine	86-96	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
29702981-6	2018	LOX-1 levels were correlated with the levels of uric acid (UA) (r = 0.289, P = .007), creatinine (CREA) (r = .316, P = .003), and high-density lipoprotein cholesterol (HDL-C) (r = -0.271, P = .012), whereas no statistically significant correlation was detected with the Gensini score (r = 0.157, P = .141).	Creatinine	98-102	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
29046330-2	2018	Glomerular filtration rate (GFR) is a key marker of renal function, but direct measurement is invasive; in routine practice, equations are used for estimated GFR (eGFR) from serum creatinine.	Creatinine	180-190	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	28-31
29046330-2	2018	Glomerular filtration rate (GFR) is a key marker of renal function, but direct measurement is invasive; in routine practice, equations are used for estimated GFR (eGFR) from serum creatinine.	Creatinine	180-190	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	158-161
29507273-10	2018	A urinary CD80 cutoff value of 1.5 ng/gm creatinine showed a sensitivity of 100% and a specificity of 86% for diagnosis of MCD.	Creatinine	41-51	CD80 molecule	Homo sapiens	10-14
29024174-2	2018	Here a complex hydride made of Li2 NH and LiBH4 was synthesized, which has a structure tentatively indexed using an orthorhombic cell with a space group of Pna21 and lattice parameters of a=10.121, b=6.997, and c=11.457 A.	Creatinine	15-22	ATP binding cassette subfamily A member 12	Homo sapiens	31-34
29071817-4	2018	RESULTS: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P&lt;0.001).	Creatinine	40-50	chitinase 3 like 1	Homo sapiens	30-36
29071817-4	2018	RESULTS: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P&lt;0.001).	Creatinine	52-54	chitinase 3 like 1	Homo sapiens	30-36
29661023-6	2018	Compared with mice in the vehicle group, mice intraperitoneally injected with TAK1 inhibitor were found to have lower serum creatinine, less tubular damage and more mild fibrosis following ischemia-induced AKI.	Creatinine	124-134	mitogen-activated protein kinase kinase kinase 7	Mus musculus	78-82
29092736-8	2018	In addition, positive correlations were identified between serum Bmi-1 levels and serum creatinine, blood urea nitrogen, cystatin C concentration, and the severity of tubulointerstitial fibrosis (r = 0.248, p &lt; 0.001; r = 0.245, p &lt; 0.001; r = 0.273, p &lt; 0.001; r = 0.536, p &lt; 0.001, respectively).	Creatinine	88-98	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	65-70
34987651-7	2022	Results: Compared to Smad3WT islet therapy, treatment with Smad3KO islets produced a much better therapeutic effect on both type-1 and type-2 diabetes by significantly lowering serum levels of blood glucose and HbA1c and protected against diabetic kidney injuries by preventing an increase in serum creatinine and the development of proteinuria, mesangial matrix expansion, and fibrosis.	Creatinine	299-309	SMAD family member 3	Mus musculus	59-64
29079274-3	2018	However, the applicability of cystatin C-based equations is discouraged in patients with overt thyroid dysfunction, since serum cystatin C and creatinine levels are oppositely affected by thyroid dysfunction.	Creatinine	143-153	cystatin C	Homo sapiens	30-40
35242568-8	2022	Therefore, the serum BUN or BUN/creatinine ratio may help to identify patients with citrin deficiency during newborn screening.	Creatinine	32-42	solute carrier family 25 member 13	Homo sapiens	84-90
29340529-9	2018	A positive correlation between syndecan-1 and serum creatinine (r=0.5, P=0.001) and triglycerides (r=0.37, P=0.004), and a negative correlation with glomerular filtration rate (r=-0.33, P=0.02) were found.	Creatinine	52-62	syndecan 1	Homo sapiens	31-41
29175173-6	2018	Normalized urinary titin concentration was 965.8+-1011.9 (Mean+-SD) pmol/mg Cr in patients with DMD.	Creatinine	76-78	titin	Homo sapiens	19-24
2788582-4	1989	Initially the thrombin complex correlated with prothrombin times and factor XIII, while the elastase complex correlated with creatinine, thrombocyte count and prothrombin times in the late stages.	Creatinine	125-135	elastase, neutrophil expressed	Homo sapiens	92-100
29175173-10	2018	The median concentration of urinary titin in the youngest (aged 3-7years) and oldest (aged &gt;=16years) groups was 1468.3 and 411.3pmol/mg Cr, respectively, with significant difference.	Creatinine	140-142	titin	Homo sapiens	36-41
2520367-4	1989	GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01).	Creatinine	61-71	V-set and immunoglobulin domain containing 2	Homo sapiens	77-80
28934189-8	2017	Our analysis found that, in terms of cardiovascular morbidity and mortality, both cystatin C-based eGFR (HR 2.88, 95% CI 1.86-4.47, P&lt;0.0001) showed a higher prognostic value than creatinine-based eGFR (HR 2.83, 95% CI 1.73-4.63, P&lt;0.0001).	Creatinine	183-193	cystatin C	Homo sapiens	82-92
3278431-8	1988	Of those CsA patients switched at a mean time of 21.3 +/- 16.4 months posttransplant with mean serum creatinine of 2.40 +/- .67, current serum creatinine is 1.79 +/- .63.	Creatinine	101-111	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	9-12
3278431-8	1988	Of those CsA patients switched at a mean time of 21.3 +/- 16.4 months posttransplant with mean serum creatinine of 2.40 +/- .67, current serum creatinine is 1.79 +/- .63.	Creatinine	143-153	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	9-12
3278431-9	1988	Current mean serum creatinine values are significantly greater for patients randomized to CsA-pred (1.73 +/- .60) vs. ALG-AZA-pred (1.49 +/- .59), P = .014, even though most CsA-treated patients were eventually switched.	Creatinine	19-29	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	90-93
3278431-9	1988	Current mean serum creatinine values are significantly greater for patients randomized to CsA-pred (1.73 +/- .60) vs. ALG-AZA-pred (1.49 +/- .59), P = .014, even though most CsA-treated patients were eventually switched.	Creatinine	19-29	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	174-177
3181285-3	1988	Both the unbound renal clearance (CLR) and CLu/f were highly correlated with the creatinine clearance (CLCR).	Creatinine	81-91	clusterin	Homo sapiens	43-46
30227813-6	2018	RESULTS: The average urinary level of cystatin C was 162.87 +- 56.50 mmol/mole creatinine in the group with AKI and 68.06 +- 57.16 mmol/mole creatinine in the control group that was significantly higher in former group (p &lt; 0.001).	Creatinine	79-89	cystatin C	Homo sapiens	38-48
30227813-6	2018	RESULTS: The average urinary level of cystatin C was 162.87 +- 56.50 mmol/mole creatinine in the group with AKI and 68.06 +- 57.16 mmol/mole creatinine in the control group that was significantly higher in former group (p &lt; 0.001).	Creatinine	141-151	cystatin C	Homo sapiens	38-48
3115544-6	1987	Significant increases in both plasma creatinine and plasma urea were observed following treatment with NaF alone or with CT and NaF together, whereas CT alone had negligible effect.	Creatinine	37-47	calcitonin-related polypeptide alpha	Rattus norvegicus	121-123
30227813-9	2018	The best cutoff value of urinary cystatin C level to predict kidney injury was shown to be 41.5 mmol/mole creatinine yielding a sensitivity of 98.2% and a specificity of 46.4%.	Creatinine	106-116	cystatin C	Homo sapiens	33-43
29090609-6	2018	In addition, an increase in cystatin C level was independently associated with the risk of subclinical atherosclerosis after adjusting for age, sex, duration of diabetes, smoking, hypertension, 10-year risk of atherosclerotic cardiovascular disease risk score, serum creatinine level, total cholesterol, high-density lipoprotein cholesterol and haemoglobin A1c (odds ratio = 1.200, 95% confidence interval: 1.04-1.38, p = 0.011).	Creatinine	267-277	cystatin C	Homo sapiens	28-38
3606181-4	1987	When the preterm infants were compared with a group of 20 healthy, full term, male infants at a postnatal age of 7 days the NAG:creatinine ratio was significantly higher in the preterm group, the measurements having been taken from single urine spot samples.	Creatinine	128-138	O-GlcNAcase	Homo sapiens	124-127
28914371-7	2017	Patients with high CysC showed significantly altered creatinine, microalbuminuria, and GFR in addition to a significant higher presence of traditional CV risk factors such as arterial hypertension (p &lt; 0.001), metabolic syndrome (p &lt; 0.001), hypertrigliceridemia (p &lt; 0.001), tobacco habit (p &lt; 0.05), and a strong association with arterial stiffness (p = 0.017).	Creatinine	53-63	cystatin C	Homo sapiens	19-23
3471866-3	1987	Patients with a urinary N-acetyl-beta-D-glucosaminidase (NAG) concentration of greater than 1.5 U/mmol creatinine or a greater than 50% increase in serum creatinine relative to the pretherapy level were approximately 30 times more likely to have MTX half-lives greater than 3.5 hours than were patients with lower values for these markers; MTX clearance was always impaired if both markers were elevated.	Creatinine	103-113	O-GlcNAcase	Homo sapiens	24-55
28891088-10	2017	The relative risk (RR) of elevated serum creatinine concentration was significantly higher in geriatric dogs (outpatient RR 1.45 [95% CI: 1.23, 1.70], inpatient RR 1.43 [95% CI: 1.16, 1.76]) and lower in young dogs (outpatient RR 0.39 [95% CI: 0.26, 0.59], inpatient RR 0.44 [95% CI: 0.32, 0.62]) when compared to the measured population risk.	Creatinine	41-51	ribonucleotide reductase catalytic subunit M1	Homo sapiens	121-125
28891088-10	2017	The relative risk (RR) of elevated serum creatinine concentration was significantly higher in geriatric dogs (outpatient RR 1.45 [95% CI: 1.23, 1.70], inpatient RR 1.43 [95% CI: 1.16, 1.76]) and lower in young dogs (outpatient RR 0.39 [95% CI: 0.26, 0.59], inpatient RR 0.44 [95% CI: 0.32, 0.62]) when compared to the measured population risk.	Creatinine	41-51	ribonucleotide reductase catalytic subunit M1	Homo sapiens	161-165
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	93-103	cystatin C	Homo sapiens	19-29
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	129-139	cystatin C	Homo sapiens	19-29
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	129-139	cystatin C	Homo sapiens	19-29
30166899-14	2017	Although, the results on kidney functions showed that, CP-1 slightly elevated blood urea concentration and CP-3 &amp; CP-4 slightly elevated serum creatinine; no apparent nephrotoxic manifestations were recorded.	Creatinine	147-157	surfactant protein D	Rattus norvegicus	118-122
29183273-8	2017	Equations that include serum cystatin C provide lower prevalence estimates if compared with equations based on serum creatinine alone.	Creatinine	117-127	cystatin C	Homo sapiens	29-39
28697041-10	2017	In a multiple regression analysis, OPG emerged as an independent predictor of HOMA-IR even after controlling for age, body mass index, and creatinine.	Creatinine	139-149	TNF receptor superfamily member 11b	Homo sapiens	35-38
28614196-13	2017	After adjustment for both creatinine and cystatin C levels, higher discharge creatinine was then associated with lower long-term mortality.	Creatinine	77-87	cystatin C	Homo sapiens	41-51
3471866-3	1987	Patients with a urinary N-acetyl-beta-D-glucosaminidase (NAG) concentration of greater than 1.5 U/mmol creatinine or a greater than 50% increase in serum creatinine relative to the pretherapy level were approximately 30 times more likely to have MTX half-lives greater than 3.5 hours than were patients with lower values for these markers; MTX clearance was always impaired if both markers were elevated.	Creatinine	103-113	O-GlcNAcase	Homo sapiens	57-60
3471866-3	1987	Patients with a urinary N-acetyl-beta-D-glucosaminidase (NAG) concentration of greater than 1.5 U/mmol creatinine or a greater than 50% increase in serum creatinine relative to the pretherapy level were approximately 30 times more likely to have MTX half-lives greater than 3.5 hours than were patients with lower values for these markers; MTX clearance was always impaired if both markers were elevated.	Creatinine	154-164	O-GlcNAcase	Homo sapiens	24-55
3115019-4	1987	In diabetic patients urinary levels of NAG (356 +/- 25 vs 162 +/- 9.2 nmol/h/mg creatinine, p less than 0.0001) and albumin (21 +/- 2.5 vs 4.3 +/- 0.5 mg/24h, p less than 0.0001) were significantly higher than in the controls, while beta 2-microglobulin levels and 51Cr-EDTA clearance did not differ in the two groups.	Creatinine	80-90	O-GlcNAcase	Homo sapiens	39-42
28932781-5	2017	This article illustrates the correlation between rescaled biomarkers serum creatinine and serum cystatin C by plotting them in a 2-dimensional graph.	Creatinine	75-85	cystatin C	Homo sapiens	96-106
29026535-7	2017	CSKp infection was associated with more severe clinical symptoms, particularly a higher serum creatinine level (165.06 +- 127.01 in the CSKp group vs. 93.77 +- 84.35 mumol/L in the CRKp group, p = 0.039), but there was no significant difference in prognosis between the CSKp and CRKp groups.	Creatinine	94-104	C-terminal Src kinase	Homo sapiens	0-4
28566468-3	2017	In Smad7 gene knockout (KO) mice, more severe renal impairment including higher levels of serum creatinine and massive tubular necrosis was developed at 48 h after AKI.	Creatinine	96-106	SMAD family member 7	Mus musculus	3-8
28260391-11	2017	Syndecan-1 showed a significant positive correlation with serum creatinine (r = 0.437, p = .001), serum urea levels (r = 0.352, p = .006), and a negative correlation with eGFR (r = -0.315, p = .015) in HIV patients.	Creatinine	64-74	syndecan 1	Homo sapiens	0-10
28260391-12	2017	Syndecan-1 remained independently associated with serum creatinine and reduced GFR even after we forced variables related with HIV infection status, tenofovir use, treatment time, dyslipidemia, and others in a multivariate analysis.	Creatinine	56-66	syndecan 1	Homo sapiens	0-10
28396344-5	2017	Surprisingly, C5aR2-/- mice were most protected and had lower creatinine levels and reduced acute tubular necrosis.	Creatinine	62-72	complement component 5a receptor 2	Mus musculus	14-19
28465474-4	2017	Mice were subjected to renal ischemia for 30 min followed by reperfusion for 24 h. The results showed that Res-DAP5-NP could decreased serum creatinine (Cr) and urea nitrogen (BUN), alleviated tubular damage and oxidative stress.	Creatinine	141-151	eukaryotic translation initiation factor 4, gamma 2	Mus musculus	111-115
28465474-4	2017	Mice were subjected to renal ischemia for 30 min followed by reperfusion for 24 h. The results showed that Res-DAP5-NP could decreased serum creatinine (Cr) and urea nitrogen (BUN), alleviated tubular damage and oxidative stress.	Creatinine	153-155	eukaryotic translation initiation factor 4, gamma 2	Mus musculus	111-115
29270498-12	2017	Proteinuria (urinary protein-to-creatinine ratio) was significantly reduced in both patients with MGN and those with FSGS after 6 months of ACTHar gel alone and was further reduced among the patients with MGN with the addition of tacrolimus.	Creatinine	32-42	actinin alpha 4	Homo sapiens	117-121
28597803-11	2017	In addition, the multivariate COX regression model showed that the highest tertile of galectin-3 was associated with an increased risk for MACE (HR =2.13, 95% confidence interval: 1.24-3.68, P = 0.006), compared with the lowest tertile after adjustment for age, NT-proBNP, creatinine, uric acid, albumin, haemoglobin, and estimated glomerular filtration rate (eGFR).	Creatinine	273-283	galectin 3	Homo sapiens	86-96
28165467-10	2017	APX-115 decreased urinary albumin excretion and preserved creatinine level.	Creatinine	58-68	shroom family member 1	Mus musculus	0-3
28260100-10	2017	However, plasma BAFF levels were positively associated with serum creatinine, proteinuria, uric acid and group A Streptococcus infection index in patients with IgAN.	Creatinine	66-76	TNF superfamily member 13b	Homo sapiens	16-20
2433030-3	1987	For the first time, we have shown that the average TGF-alpha concentration for HCC patients was 21.5 +/- 20.3 micrograms per g creatinine, significantly higher than that of healthy subjects, 4.9 +/- 2.8 micrograms per g creatinine (P less than 0.001).	Creatinine	127-137	transforming growth factor alpha	Homo sapiens	51-60
2433030-3	1987	For the first time, we have shown that the average TGF-alpha concentration for HCC patients was 21.5 +/- 20.3 micrograms per g creatinine, significantly higher than that of healthy subjects, 4.9 +/- 2.8 micrograms per g creatinine (P less than 0.001).	Creatinine	220-230	transforming growth factor alpha	Homo sapiens	51-60
3544824-5	1987	Moreover, a significant inverse correlation is found between HDL2 cholesterol and serum creatinine levels.	Creatinine	88-98	junctophilin 3	Homo sapiens	61-65
3443551-4	1987	creatinine clearance values calculated over 3 h overestimated standard inulin clearance at all levels of GFR below 100 ml/min.1.73m2 (Y = 25.1 + 0.75 Cin, r = 0.77).	Creatinine	0-10	pyridoxal phosphatase	Homo sapiens	150-153
28516402-1	2017	Calcineurin inhibitors (CIs) such as cyclosporine A (CSA) and tacrolimus often cause renal dysfunction, resulting in increased serum creatinine, hyperkalemia, and hyperuricemia.	Creatinine	133-143	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	53-56
28296059-7	2017	Of the 24 peptides, P14 (alpha3127-148 ) could induce 90.5% (19/21) of WKY rats developing anti-GBM glomerulonephritis with proteinuria, elevated serum urea and creatinine, IgG linear deposit on GBM and substantial (in average 82.4 +- 5.6%) crescent formation in glomeruli.	Creatinine	161-171	S100 calcium binding protein A9	Rattus norvegicus	20-23
28734140-12	2017	Analysis of Ang-2/Ang-1 ratio and laboratory parameters in the PUUV cohort revealed a positive correlation with serum creatinine and a negative correlation with serum albumin and thrombocyte levels.	Creatinine	118-128	angiopoietin 2	Homo sapiens	12-17
3734452-5	1986	With control for age, body mass index and pulse in multivariate analyses, only the relationship of Na:K and Na:creatinine to SBP and DBP remained significant for men; a similar, though less strong and consistent, trend was found for women, and K was inversely related to SBP for women.	Creatinine	111-121	selenium binding protein 1	Homo sapiens	125-128
3522457-5	1986	There was a modest incidence of CsA toxicity as evidenced by the usual clinical monitoring and by evaluation of creatinine clearance, plasma potassium and evolution of renal parenchymal cells as studied in the course of sequential fine needle aspiration biopsies.	Creatinine	112-122	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	32-35
3907033-14	1985	Hematocrit varied inversely with serum creatinine, which was highest in CsA-treated patients with initial delayed graft function.	Creatinine	39-49	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	72-75
3156500-3	1985	beta-Thromboglobulin values in patients with preeclampsia, but not chronic hypertension with superimposed preeclampsia, correlated directly with 24-hour urinary protein loss (r = 0.93, p less than 0.001) and serum creatinine levels (r = 0.62, p less than 0.05) and inversely with creatinine clearance (r = 0.60, p = 0.05).	Creatinine	214-224	pro-platelet basic protein	Homo sapiens	0-20
3156500-3	1985	beta-Thromboglobulin values in patients with preeclampsia, but not chronic hypertension with superimposed preeclampsia, correlated directly with 24-hour urinary protein loss (r = 0.93, p less than 0.001) and serum creatinine levels (r = 0.62, p less than 0.05) and inversely with creatinine clearance (r = 0.60, p = 0.05).	Creatinine	280-290	pro-platelet basic protein	Homo sapiens	0-20
3968864-4	1985	We found high serum NAG values in those with high blood pressure, high serum total cholesterol, low serum HDL-cholesterol, or reduced creatinine clearance rate, and women with high serum uric acid, increased skinfold thickness, or high hematocrit.	Creatinine	134-144	O-GlcNAcase	Homo sapiens	20-23
3968864-5	1985	Multiple regression equation was as follows: NAG = 3.53 + 0.07 (age) + 0.14 (hematocrit) + 0.03 (total skinfold thickness) + 0.04 (systolic blood pressure) - 0.03 (HDL-cholesterol) - 0.04 (mean blood pressure) - 0.01 (creatinine clearance).	Creatinine	218-228	O-GlcNAcase	Homo sapiens	45-48
3884881-3	1985	Inulin (CIn) in creatinine (CCr) clearances during infusion were also determined and protein excretion was evaluated.	Creatinine	16-26	pyridoxal phosphatase	Homo sapiens	8-11
6176176-4	1982	The elevated beta-TG levels in the nephritic patients showed no correlation with serum creatinine, creatinine clearance or proteinuria but was significantly correlated with the degree of glomerular sclerosis (r = 0.44) (p less than 0.05).	Creatinine	87-97	pro-platelet basic protein	Homo sapiens	13-20
7288550-6	1981	When these parameters were compared with those of urea, k12 and k21, which are transfer rate constants between compartment 1 and 2, for creatinine were significantly smaller than those of urea.	Creatinine	136-146	keratin 12	Rattus norvegicus	56-59
6779876-2	1980	Using deuterated o-hydroxymandelic acid as an internal standard, five patients were found to excrete 150-340 ng mg-1 creatinine.	Creatinine	117-127	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	112-116
7389257-4	1980	Correlations were found between creatinine clearance (Clcr) and ClTB, ClM, and ClR of SCAP (r = 0.92, p less than 0.001; r = 0.84, p less than 0.005; and r = 0.84, p less than 0.005).	Creatinine	32-42	SREBF chaperone	Homo sapiens	86-90
6446588-6	1980	The mean levels of LA-PF4/beta TG antigen excreted in urine of six normal individuals and 10 patients with chronic renal failure were 57.75 and 1461.5 ng/100 mg of creatinine per day, respectively.	Creatinine	164-174	pro-platelet basic protein	Homo sapiens	19-25
28864370-8	2017	In the overall analysis, pro-BNP level significantly correlated with red blood cell (RBC), platelet, ascites, blood urea nitrogen (BUN), creatinine (Cr), Child-Pugh score, model for end-stage liver disease (MELD) score and in-hospital death; TnT-HSST level significantly correlated with white blood cell, ascites, albumin (ALB), BUN, Cr, Child-Pugh score, MELD score and in-hospital death.	Creatinine	137-147	natriuretic peptide B	Homo sapiens	29-32
28864370-8	2017	In the overall analysis, pro-BNP level significantly correlated with red blood cell (RBC), platelet, ascites, blood urea nitrogen (BUN), creatinine (Cr), Child-Pugh score, model for end-stage liver disease (MELD) score and in-hospital death; TnT-HSST level significantly correlated with white blood cell, ascites, albumin (ALB), BUN, Cr, Child-Pugh score, MELD score and in-hospital death.	Creatinine	149-151	natriuretic peptide B	Homo sapiens	29-32
27624713-8	2017	Cox proportional hazard analysis revealed that a higher BNP at T1 independently predicts 6-month mortality (hazard ratio 1.95, 95 % CI 1.067-3.578, P = 0.03) after adjustment for age, sodium, creatinine, and NYHA class-all at discharge.	Creatinine	192-202	natriuretic peptide B	Homo sapiens	56-59
28233611-8	2017	Both NKG2D and CDKN2A mRNA expression were significantly correlated with creatinine levels at 24 months after transplantation.	Creatinine	73-83	killer cell lectin like receptor K1	Homo sapiens	5-10
28480501-9	2017	CyS-C peak had a good correlation with a plasmatic creatinine peak (r = 0.579, p = 0.0009) but not with other clinical outcomes.	Creatinine	51-61	cystatin C	Homo sapiens	0-5
28513773-7	2017	Renal markers creatinine (Cr) and blood urea nitrogen (BUN) were significantly lower in the groups that received SAB.	Creatinine	14-24	SH3-domain binding protein 5	Rattus norvegicus	113-116
28513773-7	2017	Renal markers creatinine (Cr) and blood urea nitrogen (BUN) were significantly lower in the groups that received SAB.	Creatinine	26-28	SH3-domain binding protein 5	Rattus norvegicus	113-116
28108166-7	2017	In the study cohort as a whole, the CKD-EPI creatinine-cystatin C combined equation showed the highest performance, but was only slightly superior to the CKD-EPI creatinine equation.	Creatinine	44-54	cystatin C	Homo sapiens	55-65
27638235-9	2017	Serum CAF correlated positively with serum creatinine, cystatin C and negatively with eGFR on day 1, day 2 and at 6 months after kidney transplantation.	Creatinine	43-53	lysine acetyltransferase 2B	Homo sapiens	6-9
28043664-8	2017	In multivariate Cox regression analyses adjusted for age, gender, BSA, creatinine and NT-proBNP levels, galectin-3 was an independent predictor both of the all-cause mortality (HR: 2.780, 95% CI: 1.320-5.858, p=0.007) and cardiovascular mortality (HR: 3.346, 95% CI: 1.118-10.012, p=0.031).	Creatinine	71-81	galectin 3	Homo sapiens	104-114
27849191-4	2017	In the whole sample, Lp(a) was significantly positively associated with female sex and with serum creatinine, and inversely in each sex with HOMA index (ss coefficient 0.63; p&lt;0.001).	Creatinine	98-108	lipoprotein(a)	Homo sapiens	21-26
27849191-5	2017	Linear models within separate categories showed significant associations of Lp(a) only in individuals with no evidence of diabetes other than HbA1c &gt;6.5%: in women, positive association with total cholesterol and inverse relationship with creatinine were found, and in men, positive association with apolipoprotein (apo) B was determined.	Creatinine	242-252	lipoprotein(a)	Homo sapiens	76-81
28109705-4	2017	Though newer markers of glomerular function are gaining increasing traction in the clinical realm, the most prominent of which is currently cystatin C, creatinine nonetheless remains an important player in the scientific evolution of glomerular filtration rate (GFR) estimation.	Creatinine	152-162	cystatin C	Homo sapiens	140-150
6446588-6	1980	The mean levels of LA-PF4/beta TG antigen excreted in urine of six normal individuals and 10 patients with chronic renal failure were 57.75 and 1461.5 ng/100 mg of creatinine per day, respectively.	Creatinine	164-174	pro-platelet basic protein	Homo sapiens	26-33
91458-3	1979	It was concluded that patients with a beta-2 microglobulin/creatinine ratio of greater than 3.8 were likely to have metastatic breast cancer.	Creatinine	59-69	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-44
436284-3	1979	Changes occurred in the same direction when urinary NAG was measured falling from a mean of 572 +/- 298 units/mg urinary creatinine, on diagnosis to 291 +/- 176 after treatment (p less than 0.005), as compared with 177 +/- 86 in non-diabetic controls.	Creatinine	121-131	O-GlcNAcase	Homo sapiens	52-55
754392-8	1978	Renal clearance of EDC1 in (iii) averaged 3% of creatinine clearance.	Creatinine	48-58	alpha-1-microglobulin/bikunin precursor	Homo sapiens	19-23
28296256-10	2017	Bland-Altman analysis for the same cut-off showed that CKD-EPI creatinine-cystatin C and BIS2 equation underestimated and CKD-EPI cystatin C and Simple cystatin C equation overestimated measured GFR.	Creatinine	63-73	cystatin C	Homo sapiens	74-84
28260335-9	2017	Furthermore, analyses for interaction found that both pSBP and cSBP were more strongly associated with lnUACR in males, current smokers and subjects with high serum creatinine level (&gt;=87 micromol/L) when compared with females, non-current smokers and subjects with low serum creatinine level (&lt;87 micromol/L), respectively (all P for interaction&lt;0.05).	Creatinine	165-175	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	63-67
28260335-9	2017	Furthermore, analyses for interaction found that both pSBP and cSBP were more strongly associated with lnUACR in males, current smokers and subjects with high serum creatinine level (&gt;=87 micromol/L) when compared with females, non-current smokers and subjects with low serum creatinine level (&lt;87 micromol/L), respectively (all P for interaction&lt;0.05).	Creatinine	279-289	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	63-67
28140480-9	2017	There was a significant positive correlation between serum creatinine concentration (CRT) and 2 of the APPs (SAA and hepcidin; P &lt; .05).	Creatinine	59-69	serum amyloid A protein	Felis catus	109-112
27647862-4	2017	When in steady state, there is an inverse relationship between creatinine/cystatin C and GFR, allowing GFR to be estimated from either using simple equations.	Creatinine	63-73	cystatin C	Homo sapiens	74-84
27779785-1	2017	Current expressions based on serum creatinine concentration overestimate kidney function in cirrhosis, leading to significant differences between "true" and calculated glomerular filtration rate (GFR).	Creatinine	35-45	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	196-199
27779785-6	2017	A corrected creatinine was derived from the mGFR after application of the Modification of Diet in Renal Disease formula.	Creatinine	12-22	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	44-48
27779785-12	2017	The predicted equation (r2 = 74.6%) was GFR = 45.9 x (creatinine-0 836 ) x (urea-0 229 ) x (international normalized ratio-0 113 ) x (age-0.129 [Corrected November 29, 2016: originally written as "age-129."])	Creatinine	54-64	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	40-43
28150736-10	2017	We also found trends of increasing blood urea nitrogen and serum creatinine levels with increased intensity of tubular B7-1 expression.	Creatinine	65-75	CD80 molecule	Homo sapiens	119-123
4823493-0	1974	Urinary beta-glucuronidase in man: relation to urinary specific gravity and creatinine concentration.	Creatinine	76-86	glucuronidase beta	Homo sapiens	8-26
5090624-0	1971	Creatinine--height index: reply to Drs.	Creatinine	0-10	sushi repeat containing protein X-linked	Homo sapiens	35-38
33908218-14	2021	Knockdown of MIR210HG decreased blood urea nitrogen, serum creatinine, and proinflammatory cytokine levels in AKI rats.	Creatinine	59-69	MIR210 host gene	Homo sapiens	13-21
33908691-7	2021	Compared to placebo, in the exenatide-dapagliflozin group, an acute dip in eGFR was observed with creatinine-estimated GFR (-4.0 mL/min/1.73m2 [95% CI -9.3, 1.2]; p = 0.129) and cystatin C-estimated GFR (-10.4 mL/min/1.73m2 [95% CI -14.9, -5.8]; p < 0.001).	Creatinine	98-108	cystatin C	Homo sapiens	178-188
33905004-10	2021	Similar associations were obtained when other skeletal muscle surrogates were applied: serum creatinine to serum cystatin C and daily urinary creatinine excretion.	Creatinine	93-103	cystatin C	Homo sapiens	113-123
28063928-9	2017	The inhibition of miR-107 prevented the decrease of E-cadherin, the release of NAG and cell apoptosis in HK2 cells exposed to CEC-conditioned medium prepared from septic AKI patients, and preserved the normal renal morphology and decreased the serum creatinine level in septic AKI mice.	Creatinine	250-260	microRNA 107	Homo sapiens	18-25
33915077-3	2021	We previously reported that creatinine-to-cystatin C ratio is a simple marker of muscle mass.	Creatinine	28-38	cystatin C	Homo sapiens	42-52
27888752-6	2017	Multiple regression analysis revealed that pre-delivery BNP levels were negatively correlated with BMI (p&lt;0.001) and hemoglobin (p=0.002) and positively correlated with creatinine (p&lt;0.001).	Creatinine	172-182	natriuretic peptide B	Homo sapiens	56-59
27888752-7	2017	Post-delivery BNP was positively associated with body weight change during pregnancy (p=0.001) and post-delivery creatinine (p=0.010) but negatively associated with body weight loss at delivery (p&lt;0.001) and post-delivery hemoglobin (p=0.004).	Creatinine	113-123	natriuretic peptide B	Homo sapiens	14-17
27888752-9	2017	Plasma BNP levels are affected by BMI, body weight changes, creatinine and hemoglobin levels; therefore, these factors should be considered when analysing cardiac function and the physiological implications of BNP levels in pregnant women.	Creatinine	60-70	natriuretic peptide B	Homo sapiens	7-10
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	9-19	cystatin C	Homo sapiens	253-263
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	9-19	cystatin C	Homo sapiens	253-263
27138369-5	2017	CysC was significantly correlated with serum creatinine (r=0.473, p&lt;0.001), and serum uric acid (SUA) (r=0.546, p&lt;0.001).	Creatinine	45-55	cystatin C	Homo sapiens	0-4
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	239-249	cystatin C	Homo sapiens	23-33
27138369-8	2017	CONCLUSIONS: CysC had significant associations with both creatinine and SUA in Japanese junior high school students.	Creatinine	57-67	cystatin C	Homo sapiens	13-17
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	239-249	cystatin C	Homo sapiens	253-263
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	239-249	cystatin C	Homo sapiens	253-263
33915077-9	2021	RESULTS: Creatinine-to-cystatin C ratio was positively associated with the cross-sectional area of muscle fiber-rich muscles, while it showed an inverse association with fat-rich muscle areas, resulting in the positive association between creatinine-to-cystatin C ratio and the mean attenuation value of the skeletal muscle [creatinine-to-cystatin C ratio quartiles (Q), Q1: 47.4 +- 4.8, Q2: 48.9 +- 4.4, Q3: 49.8 +- 4.1, Q4: 50.9 +- 3.7, P < .001].	Creatinine	325-335	cystatin C	Homo sapiens	23-33
33915077-11	2021	Low creatinine-to-cystatin C ratio was independently associated with 1-leg standing time, although the association was attenuated substantially by adjusting for skeletal muscle cross-sectional area and mean attenuation value.	Creatinine	4-14	cystatin C	Homo sapiens	18-28
28407629-2	2017	This study aims to validate commonly used equations for estimated GFR (eGFR) based on creatinine (cr), cystatin C (cys), beta-trace protein (BTP), and beta2-microglobulin (B2M) in older adults.	Creatinine	86-96	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	66-69
28407629-2	2017	This study aims to validate commonly used equations for estimated GFR (eGFR) based on creatinine (cr), cystatin C (cys), beta-trace protein (BTP), and beta2-microglobulin (B2M) in older adults.	Creatinine	86-88	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	66-69
33915077-12	2021	CONCLUSION AND IMPLICATIONS: Creatinine-to-cystatin C ratio was associated with myosteatosis in older adults, independent of the muscle mass.	Creatinine	29-39	cystatin C	Homo sapiens	43-53
33915077-13	2021	Creatinine-to-cystatin C ratio may serve as a convenient marker of sarcopenia.	Creatinine	0-10	cystatin C	Homo sapiens	14-24
33901548-8	2021	APOL1 high-risk genotype participants were at higher risk of having both an eGFR under 60 ml/min/1.73m2 and urine/albumin creatinine ratio over 300 mg/g (5.56, 1.57-19.69).	Creatinine	122-132	apolipoprotein L1	Homo sapiens	0-5
27690339-6	2016	Worsening of renal function (&gt;=0.3mg/dl increase in serum creatinine) was observed in 9.8% of echo-BNP-guided group and in 21.4% of clinical assessed group (p&lt;0.0001).	Creatinine	61-71	natriuretic peptide B	Homo sapiens	102-105
33893369-5	2021	Analysis using mixed effects models for repeated measures with adjustment for age and sex showed that serum SDC-1 levels measured the day before significantly affected several outcomes, including aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine (CRE), blood urea nitrogen (BUN), antithrombin III, fibrin degradation products, and D-dimer.	Creatinine	258-268	syndecan 1	Homo sapiens	108-113
27893762-9	2016	Furthermore, we detected weak U-shaped associations between serum creatinine concentrations or eGFR(crea) and serum Ang-2 concentrations.	Creatinine	66-76	angiopoietin 2	Homo sapiens	116-121
33893369-5	2021	Analysis using mixed effects models for repeated measures with adjustment for age and sex showed that serum SDC-1 levels measured the day before significantly affected several outcomes, including aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine (CRE), blood urea nitrogen (BUN), antithrombin III, fibrin degradation products, and D-dimer.	Creatinine	270-273	syndecan 1	Homo sapiens	108-113
33893369-6	2021	Moreover, serum SDC-1 levels of the prior day significantly modified the effect between time and several outcomes, including AST, ALT, CRE, and BUN.	Creatinine	135-138	syndecan 1	Homo sapiens	16-21
27855638-10	2016	The administration of shRNA against MLL3 (an H3K4 methyltransferase) to LPS-treated mice and cultured podocytes co-cultured with LPS-stimulated macrophages ameliorated podocyte swelling, an elevation in the serum creatinine and urine albumin levels and an increased expression of histone H3K4 me3 and cathepsin L, and a decreased expression of synaptopodin and increase in histone H3K4 me3 levels at the cathepsin L promoter.	Creatinine	213-223	lysine (K)-specific methyltransferase 2C	Mus musculus	36-40
34051579-2	2021	Augmented renal clearance (ARC), a phenomenon characterized by creatinine clearance (CrCl) greater than 130 ml/min/1.73m2, is commonly described in critically ill patients.	Creatinine	63-73	activity regulated cytoskeleton associated protein	Homo sapiens	27-30
27855638-10	2016	The administration of shRNA against MLL3 (an H3K4 methyltransferase) to LPS-treated mice and cultured podocytes co-cultured with LPS-stimulated macrophages ameliorated podocyte swelling, an elevation in the serum creatinine and urine albumin levels and an increased expression of histone H3K4 me3 and cathepsin L, and a decreased expression of synaptopodin and increase in histone H3K4 me3 levels at the cathepsin L promoter.	Creatinine	213-223	SET domain containing (lysine methyltransferase) 7	Mus musculus	45-67
27792322-1	2016	We report the stepwise, quantitative transformation of CeIV6(mu3-O)4(mu3-OH)4(OH)6(OH2)6 nodes in a new Ce-BTC (BTC = trimesic acid) metal-organic framework (MOF) into the first CeIII6(mu3-O)4(mu3-OLi)4(H)6(THF)6Li6 metal-hydride nodes that effectively catalyze hydroboration and hydrophosphination reactions.	Creatinine	222-229	lysine acetyltransferase 8	Homo sapiens	133-162
27605629-8	2016	The creatinine increases were accompanied by a rise in the levels of urinary renal damage markers [beta-2-microglobulin (B2M), total protein, kidney injury molecule (KIM1), alpha-glutathione S-transferase (aGST), N-acetyl-beta-(d)-glucosaminidase (NAG)].	Creatinine	4-14	O-GlcNAcase	Homo sapiens	213-246
27605629-8	2016	The creatinine increases were accompanied by a rise in the levels of urinary renal damage markers [beta-2-microglobulin (B2M), total protein, kidney injury molecule (KIM1), alpha-glutathione S-transferase (aGST), N-acetyl-beta-(d)-glucosaminidase (NAG)].	Creatinine	4-14	O-GlcNAcase	Homo sapiens	248-251
27781344-4	2017	There were four patients identified, all of whom had a history of rising creatinine, recurrent UTI, and increasing hydronephrosis which led to the diagnosis of high-grade VUR.	Creatinine	73-83	VUR	Homo sapiens	171-174
27924061-10	2017	In net reclassification improvement and integrated discrimination improvement models, PIIINP and MMP-2 significantly improved the predictive power of age, creatinine and brain natriuretic peptide.	Creatinine	155-165	matrix metallopeptidase 2	Homo sapiens	97-102
27722961-15	2017	However, for patients with protein-creatinine ratio &gt;500 mg/g (albumin-creatinine ratio &gt; 300 mg/g), with or without diabetes, lower SBP target should be proposed for renal protection aiming SBP &lt; 130 mmHg as recommended by KDIGO guidelines.In patients at low or intermediate risk, without cardiovascular disease, SBP should start to be treated when SBP is above 140 mmHg, and when treated, target BP should be less than 140 mmHg as reported by HOPE-3 trial.	Creatinine	35-45	selenium binding protein 1	Homo sapiens	139-142
27497618-7	2017	Serum TARC levels positively correlated with age, white blood cell (WBC) count, neutrophil count, eosinophil count, monocyte count, atypical lymphocyte (Aty-ly) count, serum blood urea nitrogen (BUN) levels, and creatinine (Cr) levels.	Creatinine	212-222	C-C motif chemokine ligand 17	Homo sapiens	6-10
27497618-7	2017	Serum TARC levels positively correlated with age, white blood cell (WBC) count, neutrophil count, eosinophil count, monocyte count, atypical lymphocyte (Aty-ly) count, serum blood urea nitrogen (BUN) levels, and creatinine (Cr) levels.	Creatinine	224-226	C-C motif chemokine ligand 17	Homo sapiens	6-10
27742519-11	2017	CONCLUSIONS: High creatinine at presentation is a risk factor that might aid in early identification of pediatric patients with high risk for bacteremia and its complications.	Creatinine	18-28	activation induced cytidine deaminase	Homo sapiens	73-76
27611976-7	2017	Using Pearson"s correlation coefficient, serum creatinine-to-serum cystatin C ratio was found to be the best performer in the estimation of muscle mass.	Creatinine	47-57	cystatin C	Homo sapiens	67-77
33894713-2	2021	The serum creatinine/ cystatin C ratio (CCR) is a new, simple tool that could serve as a biomarker of skeletal muscle mass.	Creatinine	10-20	cystatin C	Homo sapiens	22-32
28699485-11	2017	Serum Nampt was positively correlated with IL-1beta and urinary albumin-to-creatinine ratio (UACR) (P &lt;0.01), and IL-1beta and UACR were independent relevant factors affecting Nampt.	Creatinine	75-85	nicotinamide phosphoribosyltransferase	Homo sapiens	6-11
27932106-1	2016	INTRODUCTION: The 2013 Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline suggests measuring cystatin C (sCys) in adults with glomerular filtration rate (GFR) based on creatinine (sCr) between 45 and 59 mL/min/1.73 m2 if confirmation of chronic kidney disease (CKD) is required.	Creatinine	188-198	cystatin C	Homo sapiens	113-123
33843816-8	2021	Cystatin-C level was positively correlated with serum creatinine and urea and negatively correlated with glomerular filtration rate.	Creatinine	54-64	cystatin C	Homo sapiens	0-10
33098923-0	2021	Creatinine-Cystatin C Ratio and Mortality in Patients Receiving Intensive Care and Continuous Kidney Replacement Therapy: A Retrospective Cohort Study.	Creatinine	0-10	cystatin C	Homo sapiens	11-21
33098923-6	2021	PREDICTOR: Baseline serum creatinine:cystatin C ratio at the time of CKRT initiation.	Creatinine	26-36	cystatin C	Homo sapiens	37-47
33098923-8	2021	ANALYTICAL APPROACH: Cox proportional hazard models to estimate the association between creatinine:cystatin C ratio and outcome.	Creatinine	88-98	cystatin C	Homo sapiens	99-109
33098923-10	2021	The range of creatinine:cystatin C ratio was 0.08-10.48.	Creatinine	13-23	cystatin C	Homo sapiens	24-34
33098923-11	2021	The 30- and 90-day mortality rates were significantly lower for the higher creatinine:cystatin C ratio groups.	Creatinine	75-85	cystatin C	Homo sapiens	86-96
33098923-12	2021	Multivariable Cox proportional hazards regression analyses revealed that the mortality risk decreased successively across quartiles of increasing creatinine:cystatin C ratio.	Creatinine	146-156	cystatin C	Homo sapiens	157-167
33098923-13	2021	When creatinine:cystatin C ratio was evaluated using cubic spline analyses, the risks for both 30- and 90-day mortality were lower with higher creatinine:cystatin C ratios.	Creatinine	5-15	cystatin C	Homo sapiens	16-26
33098923-13	2021	When creatinine:cystatin C ratio was evaluated using cubic spline analyses, the risks for both 30- and 90-day mortality were lower with higher creatinine:cystatin C ratios.	Creatinine	5-15	cystatin C	Homo sapiens	154-164
33098923-13	2021	When creatinine:cystatin C ratio was evaluated using cubic spline analyses, the risks for both 30- and 90-day mortality were lower with higher creatinine:cystatin C ratios.	Creatinine	143-153	cystatin C	Homo sapiens	16-26
33098923-13	2021	When creatinine:cystatin C ratio was evaluated using cubic spline analyses, the risks for both 30- and 90-day mortality were lower with higher creatinine:cystatin C ratios.	Creatinine	143-153	cystatin C	Homo sapiens	154-164
33098923-16	2021	CONCLUSIONS: Higher creatinine:cystatin C ratios were associated with better survival in patients receiving intensive care and CKRT.	Creatinine	20-30	cystatin C	Homo sapiens	31-41
33539328-7	2021	Her FSGS relapses were further confirmed by increase in serum creatinine and proteinuria.	Creatinine	62-72	actinin alpha 4	Homo sapiens	4-8
27138468-10	2016	Patients with MGN presented with the highest proteinuria (protein excretion, 8.3g) whereas patients with FSGS had the highest creatinine levels (2.6mg/dL).	Creatinine	126-136	actinin alpha 4	Homo sapiens	105-109
27464656-5	2016	Later, this established correlation (Ln(NAG) = 0.51 x Ln(UCd) + 0.83) was applied to derive the UCd BMD5 of 1.76 mug/g creatinine and 95 % lower confidence limit of BMD5 (BMDL5) of 1.67 mug/g creatinine.	Creatinine	119-129	O-GlcNAcase	Homo sapiens	40-43
27464656-5	2016	Later, this established correlation (Ln(NAG) = 0.51 x Ln(UCd) + 0.83) was applied to derive the UCd BMD5 of 1.76 mug/g creatinine and 95 % lower confidence limit of BMD5 (BMDL5) of 1.67 mug/g creatinine.	Creatinine	192-202	O-GlcNAcase	Homo sapiens	40-43
27635179-11	2016	Cox proportional hazard analysis revealed that BNP increase at the time of discharge was an independent predictor of 6-month all-cause mortality after adjustment for age, sodium at discharge, creatinine at discharge and New York Heart Association (NYHA) class at discharge (hazard ratio 34.49; 95% confidence intervals: 4.55 - 261.06; P = 0.001).	Creatinine	192-202	natriuretic peptide B	Homo sapiens	47-50
33546466-2	2021	We hypothesized that combined analysis of serum creatinine, myo-inositol, dimethyl sulfone, and valine would allow both assessment of renal dysfunction and precise GFR estimation.	Creatinine	48-58	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	164-167
27749565-5	2016	In univariate linear regression, the log-transformed S14 level (logS14) was positively associated with fT4 but negatively associated with creatinine (Cre), total cholesterol (T-C), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and TSH.	Creatinine	138-148	thyroid hormone responsive	Homo sapiens	53-56
27749565-5	2016	In univariate linear regression, the log-transformed S14 level (logS14) was positively associated with fT4 but negatively associated with creatinine (Cre), total cholesterol (T-C), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and TSH.	Creatinine	150-153	thyroid hormone responsive	Homo sapiens	53-56
27340283-8	2016	eGFR cystatin C underestimated measured GFR by -13.7% (percentage of estimates within 30% of measured GFR of 77.1%), and eGFR creatinine-cystatin C underestimated measured GFR by -8.1% (percentage of estimates within 30% of measured GFR of 86.5%).	Creatinine	126-136	cystatin C	Homo sapiens	137-147
27340283-11	2016	CONCLUSIONS: Thus, eGFR creatinine and eGFR creatinine-cystatin C are preferred over eGFR cystatin C in kidney transplant recipients because they are less biased, more accurate, and more consistently reflect the same risk factor associations seen with measured GFR.	Creatinine	44-54	cystatin C	Homo sapiens	55-65
27662452-6	2016	CysC level correlated significantly with age (r=0.494, P<0.001), sex (r=0.150, P=0.011), and serum creatinine level (r=0.377, P<0.001), but not with levels of urea or uric acid (P>0.05).	Creatinine	99-109	cystatin C	Homo sapiens	0-4
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 47 member 2	Homo sapiens	297-303
28250989-0	2017	Apolipoprotein C-I Levels Are Associated with the Urinary Protein/Urinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study.	Creatinine	74-84	apolipoprotein C1	Homo sapiens	0-18
27075010-8	2016	Urine protein to urine creatinine ratio (P/C) correlated with urinary HMGB-1 (r = 0.52, p &lt; 0.001), but across the classes this was true only for membranous disease (r = 0.71, p = 0.022, proliferative, p = 0.63; mixed, p = 0.34).	Creatinine	23-33	high mobility group box 1	Homo sapiens	70-76
27846813-6	2016	G-CSF treatment also decreased serum levels of BUN and creatinine, and ultimately decreased mortality of NZB/W F1 mice.	Creatinine	55-65	colony stimulating factor 3 (granulocyte)	Mus musculus	0-5
27605163-9	2016	Biologically active NGAL significantly blunted the rise in serum creatinine (NGAL plus cisplatin 1.33 +- 0.31 versus cisplatin alone 2.43 +- 0.31 mg/dL, p &lt; .001) as well as the increase in urine NAG (NGAL plus cisplatin 60.7 +- 14.2 versus cisplatin alone 120.5 +- 22.5 units/gm creatinine, p &lt; .005).	Creatinine	65-75	lipocalin 2	Mus musculus	20-24
27605163-9	2016	Biologically active NGAL significantly blunted the rise in serum creatinine (NGAL plus cisplatin 1.33 +- 0.31 versus cisplatin alone 2.43 +- 0.31 mg/dL, p &lt; .001) as well as the increase in urine NAG (NGAL plus cisplatin 60.7 +- 14.2 versus cisplatin alone 120.5 +- 22.5 units/gm creatinine, p &lt; .005).	Creatinine	65-75	lipocalin 2	Mus musculus	77-81
27605163-9	2016	Biologically active NGAL significantly blunted the rise in serum creatinine (NGAL plus cisplatin 1.33 +- 0.31 versus cisplatin alone 2.43 +- 0.31 mg/dL, p &lt; .001) as well as the increase in urine NAG (NGAL plus cisplatin 60.7 +- 14.2 versus cisplatin alone 120.5 +- 22.5 units/gm creatinine, p &lt; .005).	Creatinine	65-75	lipocalin 2	Mus musculus	77-81
27605163-9	2016	Biologically active NGAL significantly blunted the rise in serum creatinine (NGAL plus cisplatin 1.33 +- 0.31 versus cisplatin alone 2.43 +- 0.31 mg/dL, p &lt; .001) as well as the increase in urine NAG (NGAL plus cisplatin 60.7 +- 14.2 versus cisplatin alone 120.5 +- 22.5 units/gm creatinine, p &lt; .005).	Creatinine	283-293	lipocalin 2	Mus musculus	20-24
30023219-6	2016	The G-CSF group exhibited protection against renal injury manifested by reducing blood urea nitrogen and serum-creatinine levels, improving histological architecture, and increasing the proliferative capacity of renal tubules.	Creatinine	111-121	colony stimulating factor 3	Rattus norvegicus	4-9
33613527-11	2020	Cellular immune dysregulation with EBNA-1 immunization in mCD40-LMP1 Tg mice was accompanied by enhanced splenomegaly, increased serum blood urea nitrogen (BUN) and creatinine levels, and elevated anti-dsDNA and antinuclear antibody (ANA) levels (p<0.0001 compared to mCD40 WT mice).	Creatinine	165-175	CD40 antigen	Mus musculus	58-63
34013114-6	2021	Results: In the albumin/creatinine ratio (ACR) <3 cohort, the only biomarker significantly associated with estimated glomerular filtration rate < 60 ml/min was N-acetyl-beta-d-glucosaminidase.	Creatinine	24-34	O-GlcNAcase	Homo sapiens	160-191
25294234-3	2016	The aim of this cross-sectional study was to investigate the association of cystatin C-based eGFR (eGFRcys) and creatinine-based eGFR (eGFRcreat), the commonly used method to assess kidney function, with periodontitis in 502 Japanese women (average age, 68.6 years).	Creatinine	112-122	cystatin C	Homo sapiens	76-86
27232923-5	2016	Those with extremely elevated BNP were older (P=0.004), with a lower body mass index (P&lt;0.0001), higher blood urea nitrogen (P=0.01), higher creatinine (P=0.005), lower cardiac output (P&lt;0.0001) and lower cardiac index (P=0.001).	Creatinine	144-154	natriuretic peptide B	Homo sapiens	30-33
27242017-0	2016	Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study.	Creatinine	30-40	natriuretic peptide B	Homo sapiens	138-141
27242017-1	2016	The ratio of cystatin C to creatinine (cysC/crea) is regarded as a marker of glomerular filtration quality and predicts mortality.	Creatinine	27-37	cystatin C	Homo sapiens	13-23
27242017-8	2016	An adjusted model that accounted for kidney function (eGFR), altered glomerular structure (albuminuria), renal stress (uNGAL), and CCI showed that BNP and PTH were independently associated with cysC/crea as well as with the ratio of cystatin C-based to creatinine-based eGFR.	Creatinine	253-263	natriuretic peptide B	Homo sapiens	147-150
27494835-4	2016	Systemic toxicity was evaluated by measuring white blood cells (WBC) counts, alanine aminotransferase (ALT) levels, and creatinine clearance (CR).In vivo and ex vivo imaging indicates that DR5 mAb modification enhanced the accumulation of NPs within the xenograft tumor.	Creatinine	120-130	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	189-192
26537358-4	2016	Compared to Non-MCD-IgAN, MCD-IgAN patients were younger,with male predominance, had higher levels of proteinuria, total cholesterol and estimated glomerular filtration rate (eGFR), lower incidence of hypertension and microhematuria, lower level of serum creatinine, and had less severe glomerular, tubulointerstitial and vascular lesions in renal pathology.	Creatinine	255-265	IGAN1	Homo sapiens	30-34
27261537-7	2016	As for trough concentrations, in addition to creatinine clearance, and sex a significant association with the CES1 SNP rs8192935 (p=0.023) was detected.	Creatinine	45-55	carboxylesterase 1	Homo sapiens	110-114
27321055-6	2016	RESULTS: In a multivariable Cox regression model adjusting for age, glomerular filtration rate, and urinary albumin/creatinine ratio, higher urinary KIM-1/creatinine was associated with an increased risk for cardiovascular mortality (HR per SD increase 1.51, 95% confidence intervals 1.03-2.24, P = 0.03).	Creatinine	155-165	cytochrome c oxidase subunit 8A	Homo sapiens	28-31
27540538-8	2016	Foxp3 expression was significantly correlated to National Institutes of Health (NIH) activity and chronicity indices (P &lt; 0.05), as well as serum creatinine (P &lt; 0.01) in both groups A and B and there was a highly significant correlation with proteinuria (P &lt; 0.01) in group B with proliferative LN.	Creatinine	149-159	forkhead box P3	Homo sapiens	0-5
27709092-17	2016	CONCLUSIONS: ACP at 25  C preserved perioperative cerebral oxygenation and serum creatinine for newborns and children undergoing arch reconstruction.	Creatinine	81-91	CPAT1	Homo sapiens	13-16
23946964-4	1993	DIAGNOSIS/TESTING: Diagnosis of ADTKD-MUC1 is suspected in individuals with an elevated serum creatinine, bland urinary sediment (i.e., little blood or protein), and a family history of kidney disease inherited in an autosomal dominant manner.	Creatinine	94-104	mucin 1, cell surface associated	Homo sapiens	32-42
27145370-4	2016	In diabetic rats, CDK5 inhibitor roscovitine decreased renal fibrosis and improved renal function as demonstrated by a decrease in levels of blood urine nitrogen (BUN), serum creatinine and beta2-microglobulin.	Creatinine	175-185	cyclin-dependent kinase 5	Rattus norvegicus	18-22
32718879-0	2021	Low Creatinine Potentially Overestimates Glomerular Filtration Rate in Older Fracture Patients: A Plea for an Extensive Use of Cystatin C?	Creatinine	4-14	cystatin C	Homo sapiens	127-137
33311451-2	2020	We retrospectively reviewed 575 patients with systemic AL amyloidosis to assess the correlation between a urine albumin to creatinine ratio (uACR) and the 24hUP.	Creatinine	123-133	uridine phosphorylase 1	Homo sapiens	157-160
33327275-6	2020	Moreover, in sepsis patients, lncRNA TUG1 expression was negatively correlated with respiratory infection, serum creatinine (Scr), white blood cell (WBC), C-reactive protein (CRP), APACHE II score, and SOFA score but positively correlated with albumin (all P < .05); miR-223 expression was negatively correlated with skin and soft tissue infection and albumin but positively correlated with Scr, WBC, CRP, APACHE II score, and SOFA score (all P < 0.05).	Creatinine	113-123	taurine up-regulated 1	Homo sapiens	37-41
33303467-5	2020	The estimated glomerular filtration rate was calculated with the creatinine-cystatin C equation developed by the Chronic Kidney Disease Epidemiology Collaboration in 2012.	Creatinine	65-75	cystatin C	Homo sapiens	76-86
33136746-4	2020	METHODS: This cross-sectional analysis of pooled data from 3 large cohorts compared the associations between the 3 CKD-EPI eGFR equations (Cr, CysC, and Cr-CysC) with CIMT and CAC score using multivariable regression analysis.	Creatinine	153-155	cystatin C	Homo sapiens	156-160
33068410-4	2021	GFR was measured by iohexol clearance in the RENIS and estimated using the CKD Epidemiology Collaboration creatinine-cystatin C equation in the PREVEND study.	Creatinine	106-116	cystatin C	Homo sapiens	117-127
32450046-5	2020	EXPERT OPINION: Serum cystatin C has been well established as an early and accurate biomarker of CKD that is particularly helpful in patients for whom creatinine is an inadequate marker or for whom more cumbersome methods of glomerular filtration rate (GFR) measurement are impractical.	Creatinine	151-161	cystatin C	Homo sapiens	22-32
32719925-8	2020	Moreover, serum creatinine levels were higher in the animal group injected with ghrelin.	Creatinine	16-26	ghrelin	Mus musculus	80-87
32666494-5	2020	DLX6-AS1 expression were positively associated with the creatinine levels in the serum from the septic AKI patients.	Creatinine	56-66	prostaglandin D2 receptor	Homo sapiens	5-8
33456602-6	2020	Correlation analysis showed a positive relation of cystatin C with increased urinary albumin excretion in both groups, plasma creatinine content, BMI, and age.	Creatinine	126-136	cystatin C	Homo sapiens	51-61
26896466-8	2016	Independent determinants of galectin-3 were age (p=0.0008), female gender (p=0.04), hypertension (p=0.002), diabetes (p=0.02), reduced left ventricular ejection fraction (p=0.01), diastolic dysfunction (E/e", p=0.02) and creatinine clearance (p&lt;0.0001).	Creatinine	221-231	galectin 3	Homo sapiens	28-38
26972903-10	2016	RESULTS AND CONCLUSIONS: Both, blood cystatin C and NGAL, levels showed significant correlation with Cr (p = 0.05 and p = 0.01, respectively).	Creatinine	101-103	cystatin C	Homo sapiens	37-47
32721792-7	2020	We performed a preliminary network analysis to study YKL-40 co-expression with diagnostic markers: TNNT2/I3 (Cardiac Troponin T/I) for cardiovascular diseases, LCN2 (NGAL) and CKM (Creatinine kinase M-type) in acute kidney injury and HbA1c in type-2-diabetes.	Creatinine	181-191	chitinase 3 like 1	Homo sapiens	53-59
32447503-10	2020	Logarithmic cystatin C (CysC) had a positive correlation to creatinine (Cr) (p = 0.001, r = 0.54), CK (p = 0.048, r = 0.30), and parathormone (PTH) (p = 0.001, r = 0.49).	Creatinine	60-70	cystatin C	Homo sapiens	12-22
26984955-10	2016	COX-2(+/-) mice showed signs of kidney insufficiency, demonstrated by enhanced serum creatinine levels, quite similar to COX-2(-/-) mice, but, in contrast, serum urea remained at the control level.	Creatinine	85-95	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
26923258-3	2016	Creatinine clearance (CLCr) predicted using the Cockcroft-Gault (C&amp;G) equation with SCr was 45.23 mL/min (interquartile range [IQR]: 32.12-58.28), and the glomerular filtration rate (GFR) predicted using the Hoek equation with CysC was 45.23 mL/min (IQR: 35.40-53.79).	Creatinine	0-10	cystatin C	Homo sapiens	231-235
26616478-7	2016	Serum IGFBP-2 was a potential indicator of both global disease activity and renal disease activity in LN patients, correlated with serum creatinine levels (r = 0 658, P &lt; 0 001, n = 85) and urine protein-to-creatinine levels (r = 0 397, P &lt; 0 001, n = 85).	Creatinine	137-147	insulin like growth factor binding protein 2	Homo sapiens	6-13
26616478-7	2016	Serum IGFBP-2 was a potential indicator of both global disease activity and renal disease activity in LN patients, correlated with serum creatinine levels (r = 0 658, P &lt; 0 001, n = 85) and urine protein-to-creatinine levels (r = 0 397, P &lt; 0 001, n = 85).	Creatinine	210-220	insulin like growth factor binding protein 2	Homo sapiens	6-13
27226081-9	2016	The increase in S-cystatin C preceded the serum creatinine elevation by 4 days.	Creatinine	48-58	cystatin C	Homo sapiens	18-28
27276392-12	2016	In continuous analyses, the albumin-to-creatinine ratio was significantly associated with anemia, acidosis, hypoalbuminemia, hyperphosphatemia, hyperkalemia, hypercholesterolemia and higher serum cystatin C.	Creatinine	39-49	cystatin C	Homo sapiens	196-206
26133903-2	2016	We aimed to develop a new equation to estimate the GFR in subjects with cirrhosis and compare its performance with chronic kidney disease epidemiology collaboration (CKD-EPI) cystatin C and creatinine-cystatin C equations, which were derived in populations without cirrhosis.	Creatinine	190-200	cystatin C	Homo sapiens	201-211
27054006-12	2016	Serum visfatin correlated positively with serum urea, creatinine, glucose, and IMT, but it was negatively correlated with eGFR, Na, and HDL.	Creatinine	54-64	nicotinamide phosphoribosyltransferase	Homo sapiens	6-14
27594733-7	2016	There was positive correlation between NAG/Cr and Alb/Cr (r = 0.49, p &lt; 0.001) and between NAG/Cr and serum creatinine (r = 0.441, p &lt; 0.001).	Creatinine	54-56	O-GlcNAcase	Homo sapiens	39-42
27594733-7	2016	There was positive correlation between NAG/Cr and Alb/Cr (r = 0.49, p &lt; 0.001) and between NAG/Cr and serum creatinine (r = 0.441, p &lt; 0.001).	Creatinine	54-56	O-GlcNAcase	Homo sapiens	39-42
27594733-7	2016	There was positive correlation between NAG/Cr and Alb/Cr (r = 0.49, p &lt; 0.001) and between NAG/Cr and serum creatinine (r = 0.441, p &lt; 0.001).	Creatinine	111-121	O-GlcNAcase	Homo sapiens	94-97
27594733-8	2016	A negative correlation was found between NAG/Cr and eGFR (r = -0.432, p &lt; 0.05).	Creatinine	45-47	O-GlcNAcase	Homo sapiens	41-44
32447503-10	2020	Logarithmic cystatin C (CysC) had a positive correlation to creatinine (Cr) (p = 0.001, r = 0.54), CK (p = 0.048, r = 0.30), and parathormone (PTH) (p = 0.001, r = 0.49).	Creatinine	60-70	cystatin C	Homo sapiens	24-28
32447503-10	2020	Logarithmic cystatin C (CysC) had a positive correlation to creatinine (Cr) (p = 0.001, r = 0.54), CK (p = 0.048, r = 0.30), and parathormone (PTH) (p = 0.001, r = 0.49).	Creatinine	72-74	cystatin C	Homo sapiens	12-22
32447503-10	2020	Logarithmic cystatin C (CysC) had a positive correlation to creatinine (Cr) (p = 0.001, r = 0.54), CK (p = 0.048, r = 0.30), and parathormone (PTH) (p = 0.001, r = 0.49).	Creatinine	72-74	cystatin C	Homo sapiens	24-28
32628043-0	2020	A novel method for creatinine adjustment makes the revised Lund-Malmo GFR estimating equation applicable in children.	Creatinine	19-29	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	70-73
32628043-6	2020	Remarkable improvements in bias and accuracy were observed; P30 increased from 56% to 74% after creatinine adjustments in children with mGFR <75 mL/min/1.73 m2 (n = 932), while P30 was relatively unchanged (89-90%) at mGFR >=75 mL/min/1.73 m2 (n = 3073).	Creatinine	96-106	centromere protein V	Homo sapiens	60-63
32865097-7	2020	Among the eGFR equations, those based on cystatin C yielded the highest C indices for cardiovascular death and major bleeding: 0.628 (CKD-EPICysC) and 0.612 (CKD-EPICysC+Creatinine), respectively.	Creatinine	170-180	cystatin C	Homo sapiens	41-51
33082773-6	2020	Results: In set 1, the crude urinary levels of ApoD, Igfbp3, and creatinine-adjusted ApoD were significantly higher in the AD group relative to the control group (p = 0.003, p = 0.002, and p = 0.019, respectively), consistent with our previous proteomics results.	Creatinine	65-75	apolipoprotein D	Homo sapiens	85-89
25735716-1	2016	OBJECTIVE: To evaluate the effect on creatinine clearance (CG-CrCl, Cockcroft-Gault equation) of switching to boosted protease inhibitor (PI) monotherapy in patients receiving a triple drug antiretroviral regimen containing TDF.	Creatinine	37-47	serpin family A member 13, pseudogene	Homo sapiens	118-136
27344357-5	2016	Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Chronic Kidney Disease Epidemiology Collaboration creatinine- cystatin C equation (eGFRcr-cys).	Creatinine	143-153	cystatin C	Homo sapiens	155-165
27924804-8	2016	Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD.	Creatinine	0-10	selenium binding protein 1	Homo sapiens	83-86
26130680-7	2016	Blockade of the endothelin 1 receptor A significantly decreased hypertension (P = .001), circulating endothelin 1, and interleukin 17 (P = .004 and .003), placental preproendothelin mRNA expression (P = .016), and urinary protein:creatinine ratio (P = .007) in rats with hemolysis-elevated liver enzymes-low platelet syndrome.	Creatinine	230-240	endothelin receptor type A	Rattus norvegicus	16-37
27100419-6	2016	The estimated glomerular filtration rate was calculated using serum creatinine and cystatin C according to the CKD-EPI Creatinine-Cystatin C equation adjusted for age, sex, and race (eGFRcr-cys).	Creatinine	119-129	cystatin C	Homo sapiens	130-140
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	44-54	matrix metallopeptidase 2	Homo sapiens	154-159
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	56-58	matrix metallopeptidase 2	Homo sapiens	154-159
26892514-9	2016	A multivariate analysis revealed that the plasma BNP levels were positively correlated with age, creatinine levels and LVEDP and inversely correlated with the male gender, body mass index and HOMA-IR (homeostasis model assessment-insulin resistance) (P&lt;0.001, respectively), but not HbA1c levels.	Creatinine	97-107	natriuretic peptide B	Homo sapiens	49-52
26637934-2	2016	We sought to determine reference intervals for serum cysC-crea ratio in seniors.	Creatinine	58-62	cystatin C	Homo sapiens	53-57
26637934-14	2016	In conclusion, the cysC-crea ratio may indicate the relative retention of biologically active low-molecular weight compounds and can independently predict the risk for overall mortality and morbidity in the elderly.	Creatinine	24-28	cystatin C	Homo sapiens	19-23
33194357-7	2020	An evident increase in the excretion of urinary CD80 was found in patients with relapsed MCD compared with those in remission (598.4 +- 115.8 vs 81.78 +- 7.04 ng/g creatinine, P < 0.001) and healthy controls (598.4 +- 115.8 vs 67.44 +-  8.94  ng/g creatinine, P < 0.001).	Creatinine	164-174	CD80 molecule	Homo sapiens	48-52
27030648-15	2016	Compared with those of patients in group CT, creatinine at PIH 48 and urea nitrogen at PIH 24, 48, 72 were obviously lower in group BP (with t values from -4.23 to -2.44, P&lt;0.05 or P&lt;0.01).	Creatinine	45-55	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	59-62
26927097-9	2016	A LAL level of 0.5 was the most sensitive for detecting both histologic and noninvasive markers for disease severity, including lower white blood cell count and calcium, and elevated gamma-glutamyltransferase, creatinine, glucose, glycated hemoglobin, uric acid and coagulation function.	Creatinine	210-220	lipase A, lysosomal acid type	Homo sapiens	2-5
27069964-6	2016	The Pearson correlation coefficient analysis showed a strong direct association between the two levels of GFR measured by Schwartz equation based on serum creatinine level and Gentian method and using cystatin C (r = 0.594, P &lt; 0.001).	Creatinine	155-165	cystatin C	Homo sapiens	201-211
27069964-8	2016	The correlation between GFR values measured by using serum creatinine and serum cystatin C measurements remained meaningful even after adjustment for patients" gender and age (r = 0.724, P &lt; 0.001).	Creatinine	59-69	cystatin C	Homo sapiens	80-90
26901211-6	2016	TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg creatinine)(-1) (interquartile range, 0.41-2.95 ng (mg creatinine)(-1)).	Creatinine	87-97	treacle ribosome biogenesis factor 1	Homo sapiens	0-3
26901211-6	2016	TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg creatinine)(-1) (interquartile range, 0.41-2.95 ng (mg creatinine)(-1)).	Creatinine	142-152	treacle ribosome biogenesis factor 1	Homo sapiens	0-3
26242184-4	2016	RESULTS: Reduced glycemic response to GLP-1RAs was associated with longer duration of diabetes, insulin cotreatment, lower fasting C-peptide, lower postmeal urine C-peptide-to-creatinine ratio, and positive GAD or IA2 islet autoantibodies (P &lt;= 0.01 for all).	Creatinine	176-186	glucagon like peptide 1 receptor	Homo sapiens	38-43
26456754-6	2016	The presence of urinary ED-A was a significant independent predictor of 2-year overall survival (OS) after adjusting for age, tumor stage, lymph node stage, and urinary creatinine by multivariable Logistic Regression (p = 0.029, OR = 4.26, 95 % CI 1.16-15.71) and improved accuracy by 3.6 %.	Creatinine	169-179	ectodysplasin A	Homo sapiens	24-28
27296256-10	2016	Clusterin, MCP-1 and KIM-1 positively and significantly correlated with serum creatinine at the week following the determination of BMs in the multivariate linear regression models adjusted for other confounders.	Creatinine	78-88	clusterin	Homo sapiens	0-9
25916428-4	2015	There was a significant, but not clinically relevant, increase in serum creatinine compared with the baseline level after 3 weeks of treatment with CsA and stabilization during the maintenance phase at the group level.	Creatinine	72-82	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	148-151
26527894-9	2015	CKD-EPI-creatinine-cystatin C equation had the smallest absolute bias and the significantly highest accuracy, although it was not significantly different from CKD-EPI-cystatin C equation (P=0.523).	Creatinine	8-18	cystatin C	Homo sapiens	19-29
26527894-10	2015	CKD-EPI-creatinine-cystatin C equation had the highest accuracy to classify CKD staging (Cohen"s k=0.345), but it underestimated GFR in 32% and overestimated GFR in 18% of the CGN patients.	Creatinine	8-18	cystatin C	Homo sapiens	19-29
26527894-11	2015	CONCLUSION: CKD-EPI-creatinine-cystatin C equation estimated GFR with little bias, and the highest accuracy among CGN patients.	Creatinine	20-30	cystatin C	Homo sapiens	31-41
26194503-6	2015	RESULTS: In PHPT patients, circulating Cys-C ranged 0.45-3.13  mg/l and correlated with creatinine, age and BMI.	Creatinine	88-98	cystatin C	Homo sapiens	39-44
26550389-6	2015	The creatinine clearance from baseline to 72 hours after the procedure was higher in the BNP group than in the hydration group.	Creatinine	4-14	natriuretic peptide B	Homo sapiens	89-92
33194357-7	2020	An evident increase in the excretion of urinary CD80 was found in patients with relapsed MCD compared with those in remission (598.4 +- 115.8 vs 81.78 +- 7.04 ng/g creatinine, P < 0.001) and healthy controls (598.4 +- 115.8 vs 67.44 +-  8.94  ng/g creatinine, P < 0.001).	Creatinine	248-258	CD80 molecule	Homo sapiens	48-52
32706557-13	2020	Urinary titin (normal range: 1-3 pmol/mg creatinine) was 27.9 (16.8-59.6), 47.6 (23.5-82.4), 46.6 (24.4-97.6), 38.4 (23.6-83.0), and 49.3 (27.4-92.6) pmol/mg creatinine on days 1, 2, 3, 5, and 7, respectively.	Creatinine	41-51	titin	Homo sapiens	8-13
33382965-6	2020	RESULTS: As DKD worsened, the level of serum MRP8/14 increased gradually, and MRP8/14 has a significantly positive correlation with ACR (r = 0.349, P = 0.002), body mass index (BMI) (r = 0.288, P = 0.009), serum creatinine (Cre) (r = 0.392, P < 0.001), blood urine nitrogen (BUN) (r = 0.333, P = 0.003), systolic blood pressure (SBP) (r = 0.301, P = 0.007), and a negative correlation with the estimated glomerular filtration rate (eGFR) (r = -0.478, P < 0.001).	Creatinine	212-222	S100 calcium binding protein A8	Homo sapiens	78-85
33382965-6	2020	RESULTS: As DKD worsened, the level of serum MRP8/14 increased gradually, and MRP8/14 has a significantly positive correlation with ACR (r = 0.349, P = 0.002), body mass index (BMI) (r = 0.288, P = 0.009), serum creatinine (Cre) (r = 0.392, P < 0.001), blood urine nitrogen (BUN) (r = 0.333, P = 0.003), systolic blood pressure (SBP) (r = 0.301, P = 0.007), and a negative correlation with the estimated glomerular filtration rate (eGFR) (r = -0.478, P < 0.001).	Creatinine	224-227	S100 calcium binding protein A8	Homo sapiens	78-85
32571244-7	2020	At 15 months after the onset of TMA, his platelet count increased gradually from 40 to 150 x 103/muL with a decreased serum creatinine level and increased urine output, eventually allowing the withdrawal of dialysis therapy.	Creatinine	124-134	tripartite motif containing 37	Homo sapiens	97-100
32544009-4	2020	Paired urine and serum hCG measurements differed quite widely but were well correlated and the degree of correlation improved after creatinine correction.	Creatinine	132-142	hypertrichosis 2 (generalised, congenital)	Homo sapiens	23-26
32145589-3	2020	In our study, pharmacological activation of GPR120 by TUG891 treatment remarkably reduced the elevated serum creatinine level and attenuated tubular injury.	Creatinine	109-119	free fatty acid receptor 4	Homo sapiens	44-50
31431305-3	2020	The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass.	Creatinine	4-14	cystatin C	Homo sapiens	18-28
32475043-6	2020	Among those born preterm, lower alpha-klotho/creatinine was associated with higher systolic BP (adjusted beta (abeta): -2.58 mm Hg, 95% CI -4.99 to -0.17), lower Ang-(1-7)/creatinine (ln abeta: 0.1, 0.04-0.16), and higher Ang II/Ang-(1-7) (ln abeta: -0.14, -0.21 to -0.07).	Creatinine	45-55	angiopoietin 1	Homo sapiens	162-170
32475043-6	2020	Among those born preterm, lower alpha-klotho/creatinine was associated with higher systolic BP (adjusted beta (abeta): -2.58 mm Hg, 95% CI -4.99 to -0.17), lower Ang-(1-7)/creatinine (ln abeta: 0.1, 0.04-0.16), and higher Ang II/Ang-(1-7) (ln abeta: -0.14, -0.21 to -0.07).	Creatinine	45-55	angiopoietin 1	Homo sapiens	229-237
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	136-146	microRNA 451a	Homo sapiens	51-58
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	159-169	microRNA 451a	Homo sapiens	51-58
31838713-4	2020	The diagnosis of a false serum creatinine elevation due to monoclonal gammopathy of undetermined significance was confirmed with the serum cystatin C level at 1.05 mg/dL and the creatinine level of 0.97 mg/dL using Shikarikid-S CRE  method.	Creatinine	31-41	cystatin C	Homo sapiens	139-149
31838713-5	2020	Although cases of monoclonal gammopathy of undetermined significance with a false serum creatinine elevation as an initial presentation are rare, this condition should be considered in patients with paraproteinemia; measuring the renal function using cystatin C is important in such patients.	Creatinine	88-98	cystatin C	Homo sapiens	251-261
31957062-6	2020	Laboratory analysis showed alteration of serum creatine kinase and creatinine in the Leu389Ser ALS4 cohort.	Creatinine	67-77	senataxin	Homo sapiens	95-99
26272322-4	2015	Urinary excretion of MIF (ng/mg of urinary creatinine) was measured both pre- and post-treatment with combined steroids and cyclophosphamide.	Creatinine	43-53	macrophage migration inhibitory factor	Homo sapiens	21-24
26245758-9	2015	Renal dysfunction and ultrastructure injury were aggravated in the ApoE/ACE2 DKO mice and Ang II-infused ApoEKO mice with increased plasma levels of creatinine, blood urea nitrogen and enhanced levels of Ang II in plasma and kidneys.	Creatinine	149-159	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	90-93
25972509-4	2015	Spearman rank correlation analysis revealed an inverse correlation between tubular syndecan-1 expression and creatinine clearance at the time of biopsy (r = -0.483, P &lt; 0.03).	Creatinine	109-119	syndecan 1	Homo sapiens	83-93
25972509-8	2015	By multivariate regression analysis, we showed robust independent associations of plasma syndecan-1 with renal (plasma creatinine and plasma urea) and endothelial function parameters (plasma VEGF-A, all P &lt; 0.01).	Creatinine	119-129	syndecan 1	Homo sapiens	89-99
25655191-3	2015	Most of studies (n = 13/16) demonstrated that CysC was better correlated with clearance/trough concentration of evaluated drugs compared with creatinine.Our review supports that CysC is a good marker of renal function to predict dose of renally excreted drugs.	Creatinine	142-152	cystatin C	Homo sapiens	178-182
26178492-10	2015	Correlation Analysis: T (-24) h urinary Sema3A and urinary NGAL were positively correlated with serum creatinine, APACHE II.	Creatinine	102-112	semaphorin 3A	Homo sapiens	40-46
26066476-6	2015	Use of serum cystatin C avoids the limitations related to both diet and muscle mass that affect serum creatinine.	Creatinine	102-112	cystatin C	Homo sapiens	13-23
26015453-8	2016	Yap silencing in podocytes resulted in podocyte apoptosis, podocyte depletion, proteinuria, and an increase in serum creatinine.	Creatinine	117-127	Yes1 associated transcriptional regulator	Homo sapiens	0-3
27546995-12	2016	Pearson correlation analysis indicated that serum adropin was negatively correlated with body mass index (BMI), blood urea nitrogen, creatinine, and ACR and positively correlated with glomerular filtration rate.	Creatinine	133-143	energy homeostasis associated	Homo sapiens	50-57
26323481-6	2016	RESULTS: PRA(+)MICA(+) recipients exhibited longer time to reach optimal serum creatinine level after transplantation (P = 0.005) and had the lowest eGFR at Month 3 (P = 0.006).	Creatinine	79-89	MHC class I polypeptide-related sequence A	Homo sapiens	15-19
25894220-11	2015	In multiple regression analysis revealed that BMI and urinary creatinine excretion were significantly associated with eGFRcreat/Cin, and cancer was only associating factor with eGFRcys/Cin.	Creatinine	62-72	pyridoxal phosphatase	Homo sapiens	128-131
26116142-8	2015	Furthermore, urinary angiotensinogen was significantly increased in neonates with a urinary cystatin-C-to-creatinine ratio &gt;=2500 ng/mg, which was the optimal cut-off value to predict acute kidney injury in our previous study.	Creatinine	106-116	cystatin C	Homo sapiens	92-102
26104383-5	2015	BUN and creatinine levels were significantly increased in both Nox2(-/-) and WT mice at 4 weeks and 6 months after IRI, suggesting the development of acute and chronic kidney injury.	Creatinine	8-18	cytochrome b-245, beta polypeptide	Mus musculus	63-67
31960908-6	2020	While only a limited number of the loci that are known to regulate blood metabolites were also associated with salivary metabolites in our study, we identified several novel saliva-specific locus-metabolite associations, including associations for the AGMAT (with the metabolites 4-guanidinobutanoate and beta-guanidinopropanoate), ATP13A5 (with the metabolite creatinine) and DPYS (with the metabolites 3-ureidopropionate and 3-ureidoisobutyrate) loci.	Creatinine	361-371	agmatinase	Homo sapiens	252-257
32210821-7	2020	Administration of recombinant FGF21 to cisplatin-induced AKI mice resulted in significantly decreased blood urea nitrogen (BUN) and serum creatinine levels, as well as significantly reduced protein levels of kidney injury molecule-1 (TIM-1), C-caspase 3, and Bax.	Creatinine	138-148	fibroblast growth factor 21	Mus musculus	30-35
32044349-9	2020	Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05).	Creatinine	234-244	meteorin like, glial cell differentiation regulator	Homo sapiens	6-12
32044349-9	2020	Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05).	Creatinine	246-248	meteorin like, glial cell differentiation regulator	Homo sapiens	6-12
32044349-10	2020	Binary logistic regression analysis showed that serum Metrnl was inversely associated with VFO even after adjusted age, gender, height, TC, TG, LDL-C, ALB, BUN, Cr, and UA (odds ration [OR], 0.846; confidence interval [CI], 0.745-0.961; P = 0.010).	Creatinine	161-163	meteorin like, glial cell differentiation regulator	Homo sapiens	54-60
31541402-13	2020	In the group comparison, serum creatinine-based models were underestimated in the prediction for patient groups with age >= 60 years, abnormal BMI values and GFR < 90 ml/min/1.73 m2, for which the cystatin C-based model could solve this problem.	Creatinine	31-41	cystatin C	Homo sapiens	197-207
25634253-9	2015	UACR was positively correlated to urine NGAL-creatinine ratio (UNCR) and urine Cystatin C-creatinine ratio (UCCR) in both diabetes and pre-diabetes.	Creatinine	90-100	cystatin C	Homo sapiens	79-89
26214067-7	2015	In addition, patients whose donors carried the CYP4A11 434S variant of the F434S polymorphism displayed impaired creatinine clearance, with statistically significant differences vs. 434FF subjects throughout the whole period of study (P &lt; 0 05, P &lt; 0 01, P &lt; 0 001 and P &lt; 0 05 for 1 week, 1 month, 5 months and 1 year after grafting, respectively).	Creatinine	113-123	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26234025-14	2015	CONCLUSION: The significant advantages of cystatin C as a kidney function marker are its use in the creatinine "blind" area, in pediatric and the elderly population.	Creatinine	100-110	cystatin C	Homo sapiens	42-52
25872661-0	2015	Elevated serum creatinine in a patient with normal renal function: the value of Cystatin C.	Creatinine	15-25	cystatin C	Homo sapiens	80-90
25639483-1	2015	Monitoring of allograft function entails methods more accurate than serum creatinine and creatinine-based GFR equations (eGFR).	Creatinine	89-99	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	106-109
25927897-0	2015	Estimation of creatinine clearance using plasma creatinine or cystatin C: a secondary analysis of two pharmacokinetic studies in surgical ICU patients.	Creatinine	14-24	cystatin C	Homo sapiens	62-72
31894557-8	2020	RESULTS: In this study, 18 (50%) patients developed AKI within 48-72 h. Moreover, urine YKL-40 increased significantly within 12 h in patients who developed AKI (n = 18, 11.75 +- 1.94), but not in non-AKI patients (n = 18, 5.66 +- 3.42) ng/ml (P &lt; 0.001) and, at the same time, we did not find any significant difference in the serum creatinine levels between the two groups.	Creatinine	337-347	chitinase 3 like 1	Homo sapiens	88-94
25605813-7	2015	INCB039110 potently inhibited OCT2-mediated uptake of creatinine as well as MATE1-/MATE2-K-mediated efflux of creatinine.	Creatinine	110-120	solute carrier family 47 member 2	Homo sapiens	83-88
25402375-10	2015	Cystatin C had a negative correlation to eGFR (r=-0.29, p=0.025) and a positive one with creatinine (r=0.35, p=0.009) at reevaluation.	Creatinine	89-99	cystatin C	Homo sapiens	0-10
26118134-7	2015	We found significant difference in creatinine level in DN and NDN groups on comparison with control group.	Creatinine	35-45	necdin, MAGE family member	Homo sapiens	62-65
26232887-9	2015	On multiple regression analysis, log-BNP was significantly associated with female sex, smoking, triglyceride, and creatinine clearance in CEI.	Creatinine	114-124	natriuretic peptide B	Homo sapiens	37-40
26232887-10	2015	In non-CEI, log-BNP was significantly associated with systolic/diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol, and creatinine clearance.	Creatinine	145-155	natriuretic peptide B	Homo sapiens	16-19
31857626-4	2019	In an angiotensin II (Ang II)-induced renal injury mouse model, we found that blocking AT1R and AT2R effectively mitigates Ang II-induced increases in necroptotic tubular epithelial cell percentages, necroptosis-related RIP3 and MLKL protein expression, serum creatinine and blood urea nitrogen levels, and tubular damage scores.	Creatinine	260-270	angiotensin II receptor, type 2	Mus musculus	96-100
30890040-9	2019	RESULTS: Our data showed that the median serum PF4 concentration was negatively associated with MM response and a significant correlation between serum PF4 level and unfavorable clinical features (beta2-microglobulin, ISS stage, del17p and creatinine).	Creatinine	240-250	platelet factor 4	Homo sapiens	47-50
26249551-7	2015	Three of 14 IgAN with ANCA-positive patients showed severe clinical manifestations with crescents involving a mean of 56% glomeruli, including heavy proteinuria (mean 24-hour urine protein: 3.8 g/d), hematuria and acute renal failure (mean creatinine: 4.5 +- 3.7 mg/dL).	Creatinine	240-250	IGAN1	Homo sapiens	12-16
26345926-8	2015	Similarly in ZNF518B, rs3217 (P = 0.016) and rs10016022 (P = 0.046) were associated with high creatinine and glucose levels, respectively.	Creatinine	94-104	zinc finger protein 518B	Homo sapiens	13-20
25145934-11	2015	The aggravation of glomerular disease in miR-21-deficient mice and the positive association with albumin-to-creatinine ratio in patients with diabetic nephropathy support miR-21 as a feedback inhibitor of TGF-beta signaling and functions.	Creatinine	108-118	transforming growth factor, beta 1	Mus musculus	205-213
30880546-6	2019	Results suggested that hirudin could reduce the increased level of proteinuria, serum creatinine and urea nitrogen in IgAN models.	Creatinine	86-96	IGAN1	Homo sapiens	118-122
25877353-5	2015	The number of CD14+TLR4+ monocytes was positively correlated with estimated glomerular filtration rate (eGFR, P&lt;0.001) and the levels of hematocrit (P&lt;0.01), but negatively correlated with the levels of blood urine nitrogen, serum creatinine, and C-reactive protein (P&lt;0.001 for all), in the CKD patients.	Creatinine	237-247	CD14 molecule	Homo sapiens	14-18
26005379-3	2015	RESULTS: Serum cystatin C correlates with fibrinogen (p&lt;0.01), serum albumin (p&lt;0.01), D-dimer (p&lt;0.05), antithrombin III (p&lt;0.01) strongly in relation to the evaluation of kidney function based on serum creatinine and eGFR.	Creatinine	216-226	cystatin C	Homo sapiens	15-25
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	13-23
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	189-199
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	189-199
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	13-23
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	189-199
26005379-4	2015	By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p&lt;0.05).	Creatinine	227-237	cystatin C	Homo sapiens	189-199
26005379-5	2015	CONCLUSION: Serum cystatin C is more strongly correlated with some biomarkers (fibrinogen, serum albumin, D-dimer, antithrombin III), while simultaneously showing a stronger sensitivity in relation to total cardiovascular morbidity compared with the assessment of kidney function based on serum creatinine and eGFR.	Creatinine	295-305	cystatin C	Homo sapiens	18-28
31646979-5	2019	RESULTS: In the therapeutic regimen of CsA vs. placebo/nontreatment (P/NT), the results indicated that the CsA group had high values of CR, TR, and low values of proteinuria, serum creatinine, and plasma cholesterol when compared with those in the placebo group.	Creatinine	181-191	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	107-110
25560370-1	2015	AIM: Semaphorin 3A urinary levels represent an early, predictive biomarker of acute kidney injury and positively correlate with albumin-to-creatinine ratio and serum creatinine in hypertensive patients with chronic kidney disease.	Creatinine	139-149	semaphorin 3A	Homo sapiens	5-18
25560370-1	2015	AIM: Semaphorin 3A urinary levels represent an early, predictive biomarker of acute kidney injury and positively correlate with albumin-to-creatinine ratio and serum creatinine in hypertensive patients with chronic kidney disease.	Creatinine	166-176	semaphorin 3A	Homo sapiens	5-18
25475610-2	2015	We evaluated cystatin C (CysC) as an early biomarker of serum creatinine (SCr)-AKI and an alternative to define AKI.	Creatinine	62-72	cystatin C	Homo sapiens	13-23
31369979-5	2019	DAP metabolite concentrations were expressed as molar concentrations divided by creatinine levels and log10 transformed.	Creatinine	80-90	death associated protein	Homo sapiens	0-3
25475610-2	2015	We evaluated cystatin C (CysC) as an early biomarker of serum creatinine (SCr)-AKI and an alternative to define AKI.	Creatinine	62-72	cystatin C	Homo sapiens	25-29
25793558-7	2015	RESULTS: At 24 hours after reperfusion, serum creatinine decreased in postcond-CsA and IPC compared to ischemic group.	Creatinine	46-56	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	79-82
25815837-9	2015	The creatinine/CysC ratio increased 8 fold over 72 hours.	Creatinine	4-14	cystatin C	Homo sapiens	15-19
25713818-0	2015	Neutral binuclear rare-earth metal complexes with four mu2-bridging hydrides.	Creatinine	68-76	adaptor related protein complex 1 subunit mu 2	Homo sapiens	55-58
26310144-7	2015	The systolic blood pressure and serum creatinine level in DN patients were significantly higher in carriers of AT1R CC compared to carriers of AT1R AA genotype.	Creatinine	38-48	angiotensin II receptor type 1	Homo sapiens	111-115
26310144-7	2015	The systolic blood pressure and serum creatinine level in DN patients were significantly higher in carriers of AT1R CC compared to carriers of AT1R AA genotype.	Creatinine	38-48	angiotensin II receptor type 1	Homo sapiens	143-147
26310144-10	2015	It seems in carriers of AT1R C allele systolic blood pressure and serum creatinine level to be higher compared to the A allele carriers.	Creatinine	72-82	angiotensin II receptor type 1	Homo sapiens	24-28
25773384-4	2015	Estimated GFR (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration eGFR creatinine-cystatin C (eGFRcreat-cys) equation.	Creatinine	101-111	cystatin C	Homo sapiens	112-122
25624405-7	2015	Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels.	Creatinine	66-76	syndecan 1	Homo sapiens	33-43
31369979-10	2019	RESULTS: Median DAP metabolite concentration was 309 nmol/g creatinine at &lt;18 weeks, 316 nmol/g creatinine at 18-25 weeks, and 308 nmol/g creatinine at &gt;25 weeks of gestation.	Creatinine	60-70	death associated protein	Homo sapiens	16-19
25689147-7	2015	RESULTS: Transcript levels of IL-8 and S100A8 were significantly lower in patients with relative change in plasma creatinine less than 10% at the first postoperative day.	Creatinine	114-124	S100 calcium binding protein A8	Homo sapiens	39-45
31719758-2	2019	Leptin receptor-deficient medaka at 20 and 30 weeks of age showed hyperglycemia and hypoinsulinemia; they also showed a higher level of plasma creatinine than the control medaka.	Creatinine	143-153	leptin receptor	Oryzias latipes	0-15
31228433-6	2019	Lower estimated creatinine clearance and use of diuretics, but not standard ECG or echocardiographic indices and cardiac biomarkers, were associated with increasing SN concentrations.	Creatinine	16-26	secretogranin II	Homo sapiens	165-167
30010903-5	2019	RESULTS: The plasma fractalkine levels in IgAN patients were significantly correlated with the creatinine level and 24-h urine protein by both univariate and multivariate analysis.	Creatinine	95-105	IGAN1	Homo sapiens	42-46
30715595-1	2019	BACKGROUND: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain.	Creatinine	116-126	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	71-74
30638235-0	2019	Transformation of the hydride-containing dinitrosyl iron complex [(NO)2Fe(eta2-BH4)]- into [(NO)2Fe(eta3-HCS2)]-via reaction with CS2.	Creatinine	22-29	DNA polymerase iota	Homo sapiens	74-78
30638235-1	2019	Reaction of compounds [(NO)2Fe(TMEDA)] and [BH4]- affords the first hydride-containing dinitrosyl iron complex (DNIC) [(NO)2Fe(eta2-BH4)]- (2).	Creatinine	68-75	DNA polymerase iota	Homo sapiens	127-131
30988316-8	2019	All patients with normal serum creatinine showed increased plasmatic Neutrophil Gelatinase-Associated Lipocalin and increased urinary Retinol Binding Protein and alpha1-microglobulin.	Creatinine	31-41	matrix metallopeptidase 2	Homo sapiens	69-90
31949999-2	2020	We had previously demonstrated that mRNA expression of platelet-activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes.	Creatinine	183-193	platelet activating factor receptor	Homo sapiens	55-90
31949999-2	2020	We had previously demonstrated that mRNA expression of platelet-activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes.	Creatinine	183-193	platelet activating factor receptor	Homo sapiens	92-96
30780108-5	2019	MF and MP have obvious improved effect on kidney injury, which reduced the content of mALB/Cre (microalbumin/creatinine) in urine and improved the tubular epithelial cells edematous and renal cystic epithelial thickening.	Creatinine	109-119	albumin	Mus musculus	86-94
30729676-5	2019	Renal miR-802 level was positively correlated with functional parameters, including blood urea nitrogen and creatinine in obese mice.	Creatinine	108-118	microRNA 802	Mus musculus	6-13
30729676-9	2019	In clinical study, the circulating miR-802 level was significantly increased in obese subjects, and positively correlated with plasma creatinine level but negatively correlated with creatinine clearance.	Creatinine	134-144	microRNA 802	Mus musculus	35-42
30729676-9	2019	In clinical study, the circulating miR-802 level was significantly increased in obese subjects, and positively correlated with plasma creatinine level but negatively correlated with creatinine clearance.	Creatinine	182-192	microRNA 802	Mus musculus	35-42
29777767-9	2019	Lack of Cd14 prevented biglycan-mediated cytokine expression, recruitment of macrophages, M1 macrophage polarization as well as mitigated the tubular damage and serum creatinine levels, thereby improving renal function.	Creatinine	167-177	CD14 antigen	Mus musculus	8-12
25465167-7	2015	For instance, in 1,092 participants in the PediGFR Consortium, the P value for the association of cystatin C concentrations and rs911119 in the CST3 gene decreased from 2.7x10(-3) to 2.4x10(-8) upon adjustment for serum creatinine-based estimated glomerular filtration rate.	Creatinine	220-230	cystatin C	Homo sapiens	98-108
25465167-7	2015	For instance, in 1,092 participants in the PediGFR Consortium, the P value for the association of cystatin C concentrations and rs911119 in the CST3 gene decreased from 2.7x10(-3) to 2.4x10(-8) upon adjustment for serum creatinine-based estimated glomerular filtration rate.	Creatinine	220-230	cystatin C	Homo sapiens	144-148
25612475-8	2015	The cystatin C-based eGFR showed a similar residual association with SDMA; an oppositely directed, borderline significant association with ADMA; and a stronger residual association with insulin resistance compared with eGFR based on creatinine.	Creatinine	233-243	cystatin C	Homo sapiens	4-14
25919022-7	2015	Since the production of these four proteins with sizes similar to that of cystatin C is not co-regulated, the most likely explanation for the simultaneous increase of their creatinine-ratios in patients with eGFRcystatin C &lt;= 60% of eGFRcreatinine is that their elimination by glomerular filtration is decreased.	Creatinine	173-183	cystatin C	Homo sapiens	74-84
30640054-0	2019	Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study.	Creatinine	85-95	cystatin C	Homo sapiens	0-10
30800662-6	2019	Results: Urinary N-titin to creatinine (N-titin/Cr) was significantly increased in all patients postoperatively (43.3 +- 39.5 pmol/mg/dL on the day of operation) and remained significantly high for at least 4 days postoperatively.	Creatinine	28-38	titin	Homo sapiens	19-24
26293031-0	2015	Relationship of Changes in Cystatin-C With Serum Creatinine and Estimated Glomerular Filtration Rate in Kidney Transplantation.	Creatinine	49-59	cystatin C	Homo sapiens	27-37
26293031-10	2015	Correlation between S-Cr and Cys-C in all time-point determinations was positive and of high significance using Pearson"s correlation (r = 0.969, P &lt; .01; r = 0.951, P &lt; .01; r = 0.969, P &lt; .01; r = 0.701, P &lt; .01).	Creatinine	20-24	cystatin C	Homo sapiens	29-34
26114353-7	2015	SBP at T2 was associated with increasing age (R = 0.44), serum creatinine (R = 0.32), SUA (R = 0.30), mean preoperative SBP and DBP (R = 0.54 and 0.37, respectively), and reduced estimated glomerular filtration rate (eGFR) (R = -0.44).	Creatinine	63-73	selenium binding protein 1	Homo sapiens	0-3
25807640-9	2015	Serum levels of CAF significantly correlated with creatinine (r = 0.623, p &lt; 0.001) and cystatin C (r = 0.578, p &lt; 0.001).	Creatinine	50-60	lysine acetyltransferase 2B	Homo sapiens	16-19
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p &lt; 0.001).	Creatinine	176-186	lysine acetyltransferase 2B	Homo sapiens	46-49
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p &lt; 0.001).	Creatinine	176-186	lysine acetyltransferase 2B	Homo sapiens	168-171
25923747-6	2015	Diabetes and cardiac failure were independent risk factors for CIN a relative increase de serum creatinine (O.R.	Creatinine	96-106	pyridoxal phosphatase	Homo sapiens	63-66
30800662-6	2019	Results: Urinary N-titin to creatinine (N-titin/Cr) was significantly increased in all patients postoperatively (43.3 +- 39.5 pmol/mg/dL on the day of operation) and remained significantly high for at least 4 days postoperatively.	Creatinine	28-38	titin	Homo sapiens	42-47
30732222-11	2019	Correlation analysis showed that serum HMGB1 levels were positive significant correlated with the Birmingham Vasculitis Activity Score, hypersensitive C reactive protein (Hs-CRP), serum creatinine (Scr) and 24-hour proteinuria (all P &lt; .05).	Creatinine	186-196	high mobility group box 1	Homo sapiens	39-44
25029429-2	2015	Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), and prevalent cardiovascular disease (CVD) in 2571 AAs from the Systolic Blood Pressure Intervention Trial (SPRINT), a trial assessing effects of systolic blood pressure reduction on renal and CVD outcomes.	Creatinine	107-117	apolipoprotein L1	Homo sapiens	5-10
26517083-11	2015	RESULTS: Using CKD-EPI creatinine-cystatin C formula the eGFR in patients was 7-130 ml/min/1.73 m2 (mean 32.6; SD+-24.6).	Creatinine	23-33	cystatin C	Homo sapiens	34-44
25257760-10	2014	Statistical analysis consisted of a t-test for independent samples comparing the group with a creatinine&lt;=100mumol/L vs&gt;100 group, and univariate and multivariate Cox regression for a serum creatinine&gt;100mumol/L at 1 year and test of correlation between BMI and serum creatinine at 1 year postoperatively.	Creatinine	196-206	cytochrome c oxidase subunit 8A	Homo sapiens	169-172
25257760-10	2014	Statistical analysis consisted of a t-test for independent samples comparing the group with a creatinine&lt;=100mumol/L vs&gt;100 group, and univariate and multivariate Cox regression for a serum creatinine&gt;100mumol/L at 1 year and test of correlation between BMI and serum creatinine at 1 year postoperatively.	Creatinine	196-206	cytochrome c oxidase subunit 8A	Homo sapiens	169-172
25630320-11	2014	The creatinine-cystatin C CKD-EPI equation performed the best, with an estimated GFR of 67 +- 35 mL/min/1.73 m2.	Creatinine	4-14	cystatin C	Homo sapiens	15-25
25630320-12	2014	CONCLUSION: The new creatinine-cystatin C equation estimated GFR with little bias, and had increased precision and accuracy in our multiethnic Asian population.	Creatinine	20-30	cystatin C	Homo sapiens	31-41
25630321-0	2014	Performance of the CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equations in a multiethnic Asian population.	Creatinine	27-37	cystatin C	Homo sapiens	38-48
25630321-11	2014	The creatinine-cystatin C CKD-EPI equation performed the best, with an estimated GFR of 67 +- 35 mL/min/1.73 m2.	Creatinine	4-14	cystatin C	Homo sapiens	15-25
25630321-12	2014	CONCLUSION: The new creatinine-cystatin C equation estimated GFR with little bias, and had increased precision and accuracy in our multiethnic Asian population.	Creatinine	20-30	cystatin C	Homo sapiens	31-41
25836945-2	2015	These results suggest that creatinine elevation is associated with activation of incretin, most possibly with up-regulation of diuretic activity of GLP-1.	Creatinine	27-37	glucagon like peptide 1 receptor	Homo sapiens	148-153
25155642-3	2015	The creatinine-cystatin C Berlin Initiative Study equation (BIS_CrCys) was examined in the &gt;=70 year subgroup.	Creatinine	4-14	cystatin C	Homo sapiens	15-25
25274955-10	2015	CONCLUSIONS: Combining cystatin C and creatinine assays improves GFR estimations with P30 &gt;=90% in adults.	Creatinine	38-48	centromere protein V	Homo sapiens	86-89
30775381-7	2019	Results: Serum cystatin C levels were strongly correlated with age, creatinine, and bone status data, with significant negative correlations with stiffness, T-score, and percentage of young adult mean.	Creatinine	68-78	cystatin C	Homo sapiens	15-25
30956609-5	2019	The use of cystatin C levels, which are creatinine independent, can provide a better prediction of renal function.	Creatinine	40-50	cystatin C	Homo sapiens	11-21
30720184-9	2019	Furthermore, the high expression of YAP in DN had relevance to increasing systolic blood pressure (SBP) (r=0.484, p=0.019), blood urea nitrogen (BUN) (r=0.522, p=0.032), creatinine (Cr) (r=0.496, p=0.031), progression of DN stage (r=0.647, p=0.001) and progression of DN pathologic classification (r=0.298, p=0.033).	Creatinine	170-180	Yes1 associated transcriptional regulator	Homo sapiens	36-39
30720184-9	2019	Furthermore, the high expression of YAP in DN had relevance to increasing systolic blood pressure (SBP) (r=0.484, p=0.019), blood urea nitrogen (BUN) (r=0.522, p=0.032), creatinine (Cr) (r=0.496, p=0.031), progression of DN stage (r=0.647, p=0.001) and progression of DN pathologic classification (r=0.298, p=0.033).	Creatinine	182-184	Yes1 associated transcriptional regulator	Homo sapiens	36-39
30720184-12	2019	YAP that is correlated with SBP, BUN, Cr, DN stage, DN pathologic classification, SAlb and eGFR, suggested that inhibition of the activity of YAP might have the effect in delaying DN progression.	Creatinine	38-40	Yes1 associated transcriptional regulator	Homo sapiens	0-3
30720184-12	2019	YAP that is correlated with SBP, BUN, Cr, DN stage, DN pathologic classification, SAlb and eGFR, suggested that inhibition of the activity of YAP might have the effect in delaying DN progression.	Creatinine	38-40	Yes1 associated transcriptional regulator	Homo sapiens	142-145
32362306-7	2019	MMP-3, MMP-7, TIMP-1, and PAPP-A correlated with serum creatinine.	Creatinine	55-65	pappalysin 1	Homo sapiens	26-32
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Creatinine	112-122	cystatin C	Homo sapiens	19-29
25046079-9	2015	Serum cystatin C correlated with serum creatinine, while serum NGAL did not correlate with serum creatinine or cystatin C.	Creatinine	39-49	cystatin C	Homo sapiens	6-16
25521214-5	2015	Cystatin C-based equations have also been developed to enhance accuracy for individuals with whom creatinine-based estimates for kidney function are acknowledged to be less accurate.	Creatinine	98-108	cystatin C	Homo sapiens	0-10
25352149-7	2015	RESULTS: Serum CAF concentrations were highly correlated with serum concentrations of creatinine (r = 0.806, p = 0.002), BUN (r = 0.727, p = 0.007), cystatin c (r = 0.839, p = 0.001) and inversely to 24-h urinary output (r = -0.669, p = 0.017).	Creatinine	86-96	lysine acetyltransferase 2B	Homo sapiens	15-18
25352149-8	2015	RRF was inversely correlated with serum concentrations of CAF, cystatin c and creatinine being highest for CAF (r = -0.734, p = 0.007) followed by cystatin c (r = -0.65, p = 0.022) and creatinine (r = -0.606, p = 0.037).	Creatinine	78-88	lysine acetyltransferase 2B	Homo sapiens	107-110
25104273-7	2014	Creatinine-cystatin C-based GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation.	Creatinine	0-10	cystatin C	Homo sapiens	11-21
25104273-10	2014	After 40 months, in patients receiving eicosapentaenoic acid-docosahexaenoic acid compared with placebo, the decline in creatinine-cystatin C-based GFR was 2.1 less (95% confidence interval, 0.6 to 3.6; P&lt;0.01) ml/min per 1.73 m(2); other comparisons were not statistical significant.	Creatinine	120-130	cystatin C	Homo sapiens	131-141
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Creatinine	156-166	cystatin C	Homo sapiens	19-29
30481791-10	2019	CONCLUSIONS: The ratio serum creatinine/serum cystatin C correlates with several COPD characteristics, and it can be used to predict COPD hospitalization.	Creatinine	29-39	cystatin C	Homo sapiens	46-56
30190173-9	2018	Following ischemia-reperfusion, Rictor-/- DC mice developed higher serum creatinine levels, more severe histological damage, and greater proinflammatory cytokine production compared to littermate controls.	Creatinine	73-83	RPTOR independent companion of MTOR, complex 2	Mus musculus	32-38
25265151-7	2014	Areas under the ROC curves of CKD-EPI-creatinine, CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C equations for all-cause mortality were 0.604 (95%CI 0.561-0.647), 0.606 (95%CI 0.563-0.649; p = 0.963) and 0.606 (95%CI 0.563-0.649; p = 0.894) respectively.	Creatinine	81-91	cystatin C	Homo sapiens	92-102
24865797-9	2014	Furthermore, the SOD2 T allele was significantly associated with increased activity of CK (females: p = 0.0144) and creatinine level (females: p = 0.0276; males: p = 0.0135) in athletes.	Creatinine	116-126	superoxide dismutase 2	Homo sapiens	17-21
25512478-7	2015	In addition, serum SDC-1 levels were correlated with renal SLEDAI score (r = 0.540, p &lt; 0.001) and excretion of proteinuria as measured by spot urine protein/creatinine ratio (r = 0.538, p &lt; 0.001).	Creatinine	161-171	syndecan 1	Homo sapiens	19-24
30371283-6	2018	Cys-C was strongly correlated with creatinine ( r=0.60) and estimated glomerular filtration rate ( r=-0.68), moderately correlated with fibroblast growth factor-23 ( r=0.39), and weakly correlated with brain-type natriuretic peptide ( r=0.28) and high-sensitivity troponin I ( r=0.06) (all P&lt;0.0001).	Creatinine	35-45	cystatin C	Homo sapiens	0-5
30185506-3	2018	Deletion of tuberous sclerosis complex 1 (TSC1), an mTORC1 negative regulator, in fibroblasts (Fibro-TSC1-/-) inhibited the elevation of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1fl/fl control mice.	Creatinine	143-153	TSC complex subunit 1	Mus musculus	12-40
25142334-9	2015	RESULTS: The concentration of urinary CD80 was significantly higher in the active MCD group (689.66 +- 378.21 ng/g creatinine) than in the FSGS group (123.49 +- 167.	Creatinine	115-125	CD80 molecule	Homo sapiens	38-42
24993332-6	2014	The related cluster [Ag8(H/D){S2P(O(i)Pr)2}6](PF6) contains either a hydride or a deuteride ion, and , respectively.	Creatinine	69-76	sperm associated antigen 17	Homo sapiens	46-49
24511990-4	2014	Results showed that pre-treatment with SMAD7 prevented AngII-induced progressive renal injury by inhibiting an increase in proteinuria and serum creatinine while improving the glomerular filtration rate.	Creatinine	145-155	SMAD family member 7	Mus musculus	39-44
24887089-1	2014	INTRODUCTION: Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear.	Creatinine	92-102	cystatin C	Homo sapiens	20-30
24887089-4	2014	Cystatin C was later assayed from the stored serum used for the creatinine-based dosing.	Creatinine	64-74	cystatin C	Homo sapiens	0-10
24887089-9	2014	The optimal model used estimated GFR by the Chronic Kidney Disease Epidemiology Collaborative (CKD-EPI) creatinine-cystatin C equation (R(2) = 0.580).	Creatinine	104-114	cystatin C	Homo sapiens	115-125
24486646-14	2014	MIOX preceded the increases in creatinine concentration by approximately 2 days in human patients.	Creatinine	31-41	myo-inositol oxygenase	Homo sapiens	0-4
24560422-4	2014	RESULTS: Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p&lt;0.05).	Creatinine	150-160	serpin family F member 1	Homo sapiens	67-71
24679869-12	2014	CONCLUSIONS: In children with neuropathic bladder the cystatin C estimated glomerular filtration rate is a better screening test for early renal insufficiency that is not detected by creatinine based rate calculations.	Creatinine	183-193	cystatin C	Homo sapiens	54-64
24046272-3	2014	Persistent proteinuria or hematuria, poorly controlled hypertension, elevated serum creatinine and prevalent glomerulosclerosis are some of the risk factors that expedite the deteriorative effects of IgAN.	Creatinine	84-94	IGAN1	Homo sapiens	200-204
24548934-3	2014	RESULTS: Maternal Cr correlated positively and significantly with neonatal Cr (r = 0.677, p &lt; 0.0001) and CysC (r = 0.246, p &lt; 0.012) on day 1 of life.	Creatinine	18-20	cystatin C	Homo sapiens	109-113
24805959-7	2014	Patients with microalbuminuria (39%) and macroalbuminuria (13%) displayed significantly elevated levels of urinary plasmin(ogen) normalized to urine creatinine compared with patients with normal excretion of albumin (48%).	Creatinine	149-159	plasminogen	Homo sapiens	115-122
24998891-3	2014	METHODS: Urinary KIM-1/creatinine of 51 IgAN patients with normotension, normal renal function and proteinuria &lt; 1.0 g/24 h were tested.	Creatinine	23-33	IGAN1	Homo sapiens	40-44
24375326-5	2014	The optimal cutoff values, determined with the receiver operating characteristic (ROC) curves, were 29 mug/g creatinine for TGFalpha and 100 ng/ml for AFP, respectively.	Creatinine	109-119	transforming growth factor alpha	Homo sapiens	124-132
24255081-7	2014	The Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations containing cystatin C were found to be best for predicting death [area under the ROC curve 0.685 for CKD-EPI-cystatin C and 0.672 for CKD-EPI-creatinine-cystatin C vs 0.632 for simplified Modification of Diet in Renal Disease Study traceable to isotope dilution mass spectrometry and 0.643 for CKD-EPI (all P &lt; 0.001)].	Creatinine	216-226	cystatin C	Homo sapiens	85-95
30185506-3	2018	Deletion of tuberous sclerosis complex 1 (TSC1), an mTORC1 negative regulator, in fibroblasts (Fibro-TSC1-/-) inhibited the elevation of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1fl/fl control mice.	Creatinine	143-153	TSC complex subunit 1	Mus musculus	42-46
30185506-3	2018	Deletion of tuberous sclerosis complex 1 (TSC1), an mTORC1 negative regulator, in fibroblasts (Fibro-TSC1-/-) inhibited the elevation of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1fl/fl control mice.	Creatinine	143-153	TSC complex subunit 1	Mus musculus	101-105
30185506-3	2018	Deletion of tuberous sclerosis complex 1 (TSC1), an mTORC1 negative regulator, in fibroblasts (Fibro-TSC1-/-) inhibited the elevation of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1fl/fl control mice.	Creatinine	143-153	TSC complex subunit 1	Mus musculus	101-105
31949578-7	2018	Compared with the control (normal lipid) group, the dyslipidemia group with IgAN had higher blood uric acid, serum creatinine, blood urea nitrogen and urinary protein quantity, higher proportions of mesangial cell proliferation and renal tubular atrophy/interstitial fibrosis (IFTA), and a lower estimated glomerular filtration rate and serum albumin.	Creatinine	115-125	IGAN1	Homo sapiens	76-80
30084220-2	2018	X-ray diffraction and computational studies suggest that the complexes contain a Ru-H-Tl 3c-2e bond and can be viewed as the first sigma-complexes of period 6 main-group hydrides [CpRu{eta2 -(H-Tl)}(PP)]PF6 or [Tl{eta2 -H-RuCp(PP)}]PF6 .	Creatinine	170-178	DNA polymerase iota	Homo sapiens	185-189
26877949-7	2014	The serum cystatin C-to-creatinine ratio was inversely correlated with the CKD stage.	Creatinine	24-34	cystatin C	Homo sapiens	10-20
30084220-2	2018	X-ray diffraction and computational studies suggest that the complexes contain a Ru-H-Tl 3c-2e bond and can be viewed as the first sigma-complexes of period 6 main-group hydrides [CpRu{eta2 -(H-Tl)}(PP)]PF6 or [Tl{eta2 -H-RuCp(PP)}]PF6 .	Creatinine	170-178	sperm associated antigen 17	Homo sapiens	203-206
30084220-2	2018	X-ray diffraction and computational studies suggest that the complexes contain a Ru-H-Tl 3c-2e bond and can be viewed as the first sigma-complexes of period 6 main-group hydrides [CpRu{eta2 -(H-Tl)}(PP)]PF6 or [Tl{eta2 -H-RuCp(PP)}]PF6 .	Creatinine	170-178	DNA polymerase iota	Homo sapiens	214-218
30084220-2	2018	X-ray diffraction and computational studies suggest that the complexes contain a Ru-H-Tl 3c-2e bond and can be viewed as the first sigma-complexes of period 6 main-group hydrides [CpRu{eta2 -(H-Tl)}(PP)]PF6 or [Tl{eta2 -H-RuCp(PP)}]PF6 .	Creatinine	170-178	sperm associated antigen 17	Homo sapiens	232-235
30205620-7	2018	PE concentrations of ENA-78/VEGF/IL-8/MDC/PCS/indoxyl sulphate correlate with serum creatinine concentrations.	Creatinine	84-94	C-C motif chemokine ligand 22	Homo sapiens	38-41
29778542-10	2018	In this model, every increase in urinary mtDNA by 100 copy/muL confers a 25.0% increase in risk of doubling of serum creatinine or need of dialysis (95%CI, 0.7% to 55.1%).	Creatinine	117-127	tripartite motif containing 37	Homo sapiens	59-62
29673928-13	2018	Urine NGAL and cystatin-C levels also showed a positive correlation with microalbuminuria (urine albumin-creatinine ratio) in patients with type 2 diabetes mellitus.	Creatinine	105-115	cystatin C	Homo sapiens	15-25
24285501-13	2014	We observed a significant reduction in serum creatinine levels, ED-1, alpha-SMA, and Sirius red as well as an important induction of Oct-4, angiogenic factors, and repairing proteins in NPX+bFGF animals compared with NPX+S animals.	Creatinine	45-55	fibroblast growth factor 2	Rattus norvegicus	190-194
24864601-0	2014	Cystatin C levels in healthy kidney donors and its correlation with GFR by creatinine clearance.	Creatinine	75-85	cystatin C	Homo sapiens	0-10
24864601-1	2014	OBJECTIVE: To determine Serum Cystatin C (S.CysC) levels in healthy potential kidney donors and its correlation with Serum Creatinine (S.Cr), Glomerular filtration rate (GFR) by 24 hour urinary Creatinine clearance (CCL) and GFR by formulae of Cockcroft Gault (CCG) and Modification of diet in Renal Disease (MDRD).	Creatinine	123-133	cystatin C	Homo sapiens	30-40
24864601-1	2014	OBJECTIVE: To determine Serum Cystatin C (S.CysC) levels in healthy potential kidney donors and its correlation with Serum Creatinine (S.Cr), Glomerular filtration rate (GFR) by 24 hour urinary Creatinine clearance (CCL) and GFR by formulae of Cockcroft Gault (CCG) and Modification of diet in Renal Disease (MDRD).	Creatinine	194-204	cystatin C	Homo sapiens	30-40
24417186-8	2014	RESULTS: Serum and urine NGAL concentrations in azotemic dogs were significantly higher than in nonazotemic dogs and were highly correlated with serum creatinine concentration (P &lt; .05).	Creatinine	151-161	lipocalin 2	Canis lupus familiaris	25-29
24417647-2	2014	HYPOTHESIS: Dogs with AKI have significantly higher plasma NGAL concentration and urine NGAL-to-creatinine ratio (UNCR) compared with healthy dogs and dogs with chronic kidney disease (CKD).	Creatinine	96-106	lipocalin 2	Canis lupus familiaris	88-92
24783172-0	2014	Serum cystatin C as a marker of renal function in critically ill patients with normal serum creatinine.	Creatinine	92-102	cystatin C	Homo sapiens	6-16
28669514-7	2018	RESULTS: Higher baseline levels of urinary alanine, betaine, N,N-dimethylglycine (DMG), creatinine and trimethylamine were associated with an increase in HbA1c from baseline to follow-up.	Creatinine	88-98	hemoglobin subunit alpha 1	Homo sapiens	154-158
29795979-11	2018	Results: RAP improved the renal function indices, including 24-h albuminuria, triglyceride, serum creatinine, and blood urea nitrogen levels, but did not lower blood glucose levels in DN mice.	Creatinine	98-108	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	9-12
29567078-10	2018	KEY FINDINGS: The IP administration of BCA significantly decreased serum levels of urea, creatinine, uric acid and MDA and significantly increased serum CAT, GSH and TAC and cutaneous IL-4 and GATA3 concentrations in the fifth and sixth groups compared to OVX-DMSO and OVX-ANA groups, respectively.	Creatinine	89-99	B cell linker	Homo sapiens	39-42
29401562-10	2018	The median eGFR/mGFR ratio for the eGFR equations decreased with age and reduced kidney functions (i.e., increased creatinine and BUN concentrations).	Creatinine	115-125	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	16-20
29481425-8	2018	High secretoneurin levels on day 1 were associated with age and serum concentrations of lactate, bilirubin, creatinine, and N-terminal pro-B-type natriuretic peptide.	Creatinine	108-118	secretogranin II	Homo sapiens	5-18
29417184-7	2018	In the whole diabetic cohort, after a mean follow-up of 9 years, galectin-3 was independently associated with doubling of serum creatinine (HR 1.19; 95% CI 1.14, 1.24, p &lt; 0.001) and incident macroalbuminuria (HR 1.20; 95% CI 1.12, 1.30, p &lt; 0.001), even after adjusting for traditional risk factors, baseline eGFR and albuminuria status.	Creatinine	128-138	galectin 3	Homo sapiens	65-75
24450691-11	2014	Multivariate regression analysis showed that intraarterial contrast administration (p = 0.002) and higher baseline cystatin C (p &lt; 0.001) combined with low creatinine (p = 0.044) were independently associated with higher increases in creatinine within 48 hours after contrast administration.	Creatinine	237-247	cystatin C	Homo sapiens	115-125
24011362-15	2014	Minor decreases in eGFR influence long-term prognosis, and measurement of cystatin C levels might be useful to detect renal impairment in patients with a normal serum concentration of creatinine.	Creatinine	184-194	cystatin C	Homo sapiens	74-84
24450691-0	2014	Prediction of contrast-induced nephropathy in patients with serum creatinine levels in the upper normal range by cystatin C: a prospective study in 374 patients.	Creatinine	66-76	cystatin C	Homo sapiens	113-123
24450691-2	2014	In patients with creatinine in the upper normal level, cystatin C might be a more sensitive predictor of CIN than creatinine.	Creatinine	17-27	cystatin C	Homo sapiens	55-65
24134783-8	2014	CD14(+) CD16(-) monocytes increased at 4 months and correlated positively with creatinine levels at 12 and 24 months (r = 0 6348, P = 0 002 and r = 0 467, P = 0 028, respectively) and negatively with Modification of Diet in Renal Disease (MDRD) at 12 months (r = 0 6056, P = 0 003).	Creatinine	79-89	CD14 molecule	Homo sapiens	0-4
24396399-5	2014	Following the injection of MMP-9 into the renal arteries of the rabbits, significant improvements in renal morphology and serum levels of creatinine and urea nitrogen were observed.	Creatinine	138-148	matrix metalloproteinase-9	Oryctolagus cuniculus	27-32
24471722-1	2014	OBJECTIVES: We evaluated cystatin C concentration as a marker of glomerular filtration rate in renal transplant recipients, and its correlation with creatinine-based glomerular filtration rate by urinary creatinine clearance, and the Cockroft-Gault and Modification of Diet in Renal Disease formulas.	Creatinine	149-159	cystatin C	Homo sapiens	25-35
24471722-2	2014	MATERIALS AND METHODS: In this cross-sectional study, we measured serum cystatin C levels and its correlation with serum creatinine, creatinine clearance, and glomerular filtration rate using the Cockroft-Gault formula and Modification of Diet in Renal Disease formulas.	Creatinine	121-131	cystatin C	Homo sapiens	72-82
24471722-2	2014	MATERIALS AND METHODS: In this cross-sectional study, we measured serum cystatin C levels and its correlation with serum creatinine, creatinine clearance, and glomerular filtration rate using the Cockroft-Gault formula and Modification of Diet in Renal Disease formulas.	Creatinine	133-143	cystatin C	Homo sapiens	72-82
24471722-6	2014	Serum cystatin C was significantly correlated with serum creatinine (r=0.90; P&lt;.001), creatinine clearance (r=0.77; P&lt;.001), and the Cockroft-Gault (r=0.73; P&lt;.001) and the Modification of Diet in Renal Disease formulas (r=0.82; P&lt;.001).	Creatinine	57-67	cystatin C	Homo sapiens	6-16
24471722-6	2014	Serum cystatin C was significantly correlated with serum creatinine (r=0.90; P&lt;.001), creatinine clearance (r=0.77; P&lt;.001), and the Cockroft-Gault (r=0.73; P&lt;.001) and the Modification of Diet in Renal Disease formulas (r=0.82; P&lt;.001).	Creatinine	89-99	cystatin C	Homo sapiens	6-16
24028541-7	2014	For serum cystatin C and estimated GFR based on creatinine and cystatin C, the mortality and the hazard ratios for long-term mortality increased from the first to the fifth quintile nearly linearly.	Creatinine	48-58	cystatin C	Homo sapiens	10-20
29496508-0	2018	Decreased the creatinine to cystatin C ratio is a surrogate marker of sarcopenia in patients with type 2 diabetes.	Creatinine	14-24	cystatin C	Homo sapiens	28-38
24918488-8	2014	RESULTS: A significant positive correlation between NAG urine activity in the 3rd month after transplantation and creatinine concentration on the 14th (p=0.004) and 30th day (p=0.05), in the 3rd month (p=0.009) and after the 1st (p=0.005) and 2nd year (p=0.003) was observed.	Creatinine	114-124	O-GlcNAcase	Homo sapiens	52-55
24356416-4	2014	Estimated GFR was calculated using the Modification of Diet in Renal Disease equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation using serum creatinine only, the CKD-EPI equation using serum cystatin C only and a recently derived equation that uses both serum creatinine and cystatin C (CKD-EPIcreat-cystC) and then compared to mGFR.	Creatinine	172-182	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	10-13
24356416-4	2014	Estimated GFR was calculated using the Modification of Diet in Renal Disease equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation using serum creatinine only, the CKD-EPI equation using serum cystatin C only and a recently derived equation that uses both serum creatinine and cystatin C (CKD-EPIcreat-cystC) and then compared to mGFR.	Creatinine	291-301	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	10-13
24457210-1	2014	BACKGROUND: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown.	Creatinine	80-90	TNF receptor superfamily member 11b	Homo sapiens	21-36
24457210-1	2014	BACKGROUND: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown.	Creatinine	80-90	TNF receptor superfamily member 11b	Homo sapiens	38-41
29504713-7	2018	Compared with mice in the vehicle cisplatin group, mice intraperitoneally injected with a TAK1 inhibitor were found to have lower serum creatinine and less tubular damage following cisplatin-induced AKI.	Creatinine	136-146	mitogen-activated protein kinase kinase kinase 7	Mus musculus	90-94
24457210-4	2014	RESULTS: At baseline, participants with elevated OPG above the median (&gt;=2.2 ng/ml) had a 5.0% lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels.	Creatinine	112-122	TNF receptor superfamily member 11b	Homo sapiens	49-52
24457210-5	2014	In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively).	Creatinine	147-157	TNF receptor superfamily member 11b	Homo sapiens	61-64
29699633-6	2018	Compared with sham-operated mice, both wide-type (WT) mice and PT-miR-17-92-/- mice showed increased serum levels of creatinine and urea.	Creatinine	117-127	Mir17 host gene (non-protein coding)	Mus musculus	66-75
25322693-7	2014	RESULTS: Mice upregulated miR-21 had lower plasma levels of blood urea nitrogen (BUN) and creatinine, lower histopathological scores and a decrease in programmed cell death 4 (PDCD4) mRNA and active caspase-3, caspase-8 proteins expressions.	Creatinine	90-100	microRNA 21a	Mus musculus	26-32
25574406-5	2014	His serum creatinine increased by 5.06 mg/dL from 1.1 mg/dL 2 days after silicate ingestion.	Creatinine	10-20	l(1)L2	Drosophila melanogaster	57-61
24724425-4	2014	The histogram of relative urinary/serum hCG(U-hCG.act/S-hCG) of the samples showed a wide distribution of values, but tended to converge to a narrow distribution by creatinine correction (U-hCG.cor/S-hCG).	Creatinine	165-175	chorionic gonadotropin subunit beta 5	Homo sapiens	40-43
24092384-6	2013	I/R markedly depressed renal blood flow and increased the production in O2, PGE2, the expression in P47 and Rac-1 expression of two nicotinamide adenine dinucleotide phosphate oxidase subunits, cytosolic cytochrome C release, proapoptotic marker lamin expression, the pathologic appearance of necrosis, apoptosis, and autophagy, and blood urea nitrogen and creatinine levels in the damaged kidneys.	Creatinine	357-367	Rac family small GTPase 1	Rattus norvegicus	108-113
24453873-7	2013	In a multiple linear regression model, age, creatinine, and LVEF remained significant associates of BNP.	Creatinine	44-54	natriuretic peptide B	Homo sapiens	100-103
24376511-1	2013	BACKGROUND: Serum creatinine and cystatin C are used as markers of glomerular filtration rate (GFR).	Creatinine	18-28	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	95-98
24349116-8	2013	CONCLUSIONS: Urine IgG to albumin and urine NAG to creatinine ratio are better early predictors of treatment response in patients with ANCA-associated glomerulonephritis than proteinuria or albuminuria.	Creatinine	51-61	O-GlcNAcase	Homo sapiens	44-47
24103867-6	2013	Increasing kidney function score was correlated with increased urinary ALP:creatinine and GGT:creatinine ratios.	Creatinine	75-85	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	71-74
24223846-4	2013	We found that Smad4(co/co;Lck-cre) mice exhibited massive glomerular IgA deposition, increased albumin creatinine ratio, aberrant glycosylated IgA, IgA complexed with IgG1 and IgG2a, and polymeric IgA, all known features of IgAN in humans.	Creatinine	103-113	lymphocyte protein tyrosine kinase	Mus musculus	26-29
24591411-8	2013	Correlation analysis showed that plasma levels of HMGB-1 correlated with initial serum creatinine (r = 0.275, P = 0.018), estimated glomerular filtration rate (r = -0.277, P = 0.017), the Birmingham Vasculitis Activity Score (r = 0.308, P = 0.008), and C-reactive protein level (r = 0.309, P = 0.008).	Creatinine	87-97	high mobility group box 1	Homo sapiens	50-56
23872205-2	2013	The aims of the present study were to assess the association between age and cystatin C and creatinine based glomerular filtration rate estimates in primary care patients, and to determine the proportion of patients with clinically important renal impairment.	Creatinine	92-102	cystatin C	Homo sapiens	77-87
24114579-1	2014	BACKGROUND: A number of recent reports have suggested that the cystatin C/creatinine (CysC/Cr) ratio might be a useful biomarker of renal function in pediatric patients.	Creatinine	74-84	cystatin C	Homo sapiens	63-73
23928369-12	2014	As a result, DEHP metabolites showed the highest detected concentration (75.92 mug/g creatinine, 100%), and MiNP, a metabolite of DiNP, showed the lowest detected concentration (0.42 mug/g creatinine, 22.5%).	Creatinine	189-199	bMERB domain containing 1	Homo sapiens	108-112
29699633-7	2018	However, the levels of serum urea and creatinine in PT-miR-17-92-/- mice after the IRI operation were significantly higher than the levels in WT mice.	Creatinine	38-48	Mir17 host gene (non-protein coding)	Mus musculus	55-64
29731073-0	2018	Pretransplantation Cystatin C, but not Creatinine, Predicts 30-day Cardiovascular Events and Mortality in Liver Transplant Recipients With Normal Serum Creatinine Levels.	Creatinine	152-162	cystatin C	Homo sapiens	19-29
29731073-9	2018	CONCLUSIONS: Pretransplantation cystatin C is superior in risk prediction of MACE and all-cause mortality in LT recipients with normal creatinine, compared to creatinine.	Creatinine	135-145	cystatin C	Homo sapiens	32-42
29694420-9	2018	Using receiver operating curve (ROC), sIgA at M6 and M12 post-transplant were significantly associated with IgAN recurrence (AUC = 0.771, p = 0.004 and AUC = 0.767, p = 0.016, respectively), while serum creatinine and proteinuria were not.	Creatinine	203-213	IGAN1	Homo sapiens	108-112
29775443-9	2018	Significant correlations between BNP concentration and LVH expressed by LVMI (R=0.256, p=0.038), creatinine (R=0.453, p&lt;0.001), cystatin (R=0.494, p&lt;0.001) and eGFR (R=-0.473, p&lt;0.001) were found.	Creatinine	97-107	natriuretic peptide B	Homo sapiens	33-36
29664049-10	2018	There were significantly positive correlations between serum CysC levels and age (r = 0.334, P < 0.001), gender (r = 0.264, P = 0.013), and creatinine levels (r = 0.302, P = 0.018) in early PD patients.	Creatinine	140-150	cystatin C	Homo sapiens	61-65
29368537-9	2018	Significant improvements in urine protein or albumin to creatinine ratios were also seen among those in the TAF group versus TDF through week 96 (p &lt; .001).	Creatinine	56-66	TATA-box binding protein associated factor 8	Homo sapiens	108-111
29428484-9	2018	Recipients who were positive for AT1R-Ab prior to transplantation had increases in serum creatinine within 3 months post-transplantation (p &lt; 0.0001) and developed abnormal biopsies earlier than did AT1R-Ab negative patients (126 days versus 368 days respectively; p = 0.02).	Creatinine	89-99	angiotensin II receptor type 1	Homo sapiens	33-37
29343518-5	2018	After ischemia-reperfusion injury (IRI), Gli1-beta-cat-/- mice had lower serum creatinine levels and less morphologic injury than Gli1-beta-cat+/+ littermate controls.	Creatinine	79-89	GLI-Kruppel family member GLI1	Mus musculus	41-45
28895159-9	2018	Univariate linear regression analysis revealed that circulating ACE2 levels were positively associated with systolic blood pressure (P=.02), mean arterial pressure (P=.02) and serum creatinine (P&lt;.001) in females whereas circulating ACE2 levels were positively associated with age (P&lt;.001) and serum creatinine (P&lt;.001) in males.	Creatinine	182-192	angiotensin converting enzyme 2	Homo sapiens	64-68
28895159-9	2018	Univariate linear regression analysis revealed that circulating ACE2 levels were positively associated with systolic blood pressure (P=.02), mean arterial pressure (P=.02) and serum creatinine (P&lt;.001) in females whereas circulating ACE2 levels were positively associated with age (P&lt;.001) and serum creatinine (P&lt;.001) in males.	Creatinine	306-316	angiotensin converting enzyme 2	Homo sapiens	64-68
29558500-5	2018	By comparing significant genetic loci associated with serum creatinine levels and GFR, rs9895661 in BCAS3 and rs757608 in C17orf82 were simultaneously associated with both traits.	Creatinine	60-70	BCAS3 microtubule associated cell migration factor	Homo sapiens	100-105
24519695-4	2013	Urinary beta2-MG correlated with serum creatinine and eGFR in the whole group of lithium-treated patients and in addition, in males, with duration of illness, duration of lithium treatment, and urine specific gravity.	Creatinine	39-49	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-13
29558500-5	2018	By comparing significant genetic loci associated with serum creatinine levels and GFR, rs9895661 in BCAS3 and rs757608 in C17orf82 were simultaneously associated with both traits.	Creatinine	60-70	long intergenic non-protein coding RNA 2875	Homo sapiens	122-130
28187233-12	2018	CONCLUSIONS: Patients with CIN had lower serum levels of cystatin C defined as cystatin C/creatinine rate when they were compared with GN subject and control ones.	Creatinine	90-100	cystatin C	Homo sapiens	57-67
28865675-4	2018	At baseline, galectin-3 was cross-sectionally associated with estimated glomerular filtration rate and urine albumin-to-creatinine ratio; both significant.	Creatinine	120-130	galectin 3	Homo sapiens	13-23
24241090-6	2013	Visfatin showed significant positive correlations with low-density lipoprotein cholesterol, uric acid, blood urea nitrogen, creatinine, brain natriuretic peptide, E-selectin, total leukocyte count, neutrophil count, and high-sensitivity C-reactive protein, and a significant negative correlation with estimated glomerular filtration rate and albumin.	Creatinine	124-134	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
23726805-9	2013	The combined creatinine-cystatin C equation was significantly more accurate and precise than the CKD-EPI creatinine equation in patients with GFR above 60 mL/min/1.73 m2.	Creatinine	13-23	cystatin C	Homo sapiens	24-34
24516760-9	2014	Cystatin C had a highly significant strong negative correlation with eGFR and creatinine clearance and a significantly strong positive correlation with serum ferritin, and a higher sensitivity and specificity than serum creatinine and creatinine clearance for small changes in GFR.	Creatinine	78-88	cystatin C	Homo sapiens	0-10
24516760-9	2014	Cystatin C had a highly significant strong negative correlation with eGFR and creatinine clearance and a significantly strong positive correlation with serum ferritin, and a higher sensitivity and specificity than serum creatinine and creatinine clearance for small changes in GFR.	Creatinine	220-230	cystatin C	Homo sapiens	0-10
24516760-9	2014	Cystatin C had a highly significant strong negative correlation with eGFR and creatinine clearance and a significantly strong positive correlation with serum ferritin, and a higher sensitivity and specificity than serum creatinine and creatinine clearance for small changes in GFR.	Creatinine	220-230	cystatin C	Homo sapiens	0-10
24144866-8	2014	CD2AP correlated with serum creatinine (r=-0.373, p=0.035), BUN (r=-0.445, p=0.009) and eGFR (r=0.351, p=0.046).	Creatinine	28-38	CD2 associated protein	Homo sapiens	0-5
24311711-11	2014	An intronic variant of BCAS3 was significantly associated with urinary albumin to creatinine ratio.	Creatinine	82-92	BCAS3 microtubule associated cell migration factor	Homo sapiens	23-28
24020513-2	2013	HYPOTHESIS: Urine neutrophil gelatinase-associated lipocalin (NGAL)/creatinine ratio is a sensitive and specific biomarker of AKI in dogs.	Creatinine	68-78	lipocalin 2	Canis lupus familiaris	18-60
24020513-2	2013	HYPOTHESIS: Urine neutrophil gelatinase-associated lipocalin (NGAL)/creatinine ratio is a sensitive and specific biomarker of AKI in dogs.	Creatinine	68-78	lipocalin 2	Canis lupus familiaris	62-66
24020513-11	2013	CONCLUSIONS AND CLINICAL RELEVANCE: NGAL/creatinine ratio is a sensitive and specific marker of AKI.	Creatinine	41-51	lipocalin 2	Canis lupus familiaris	36-40
24045636-7	2013	The serum creatinine levels remained at low levels in the Adv-IKK2dn-CD4+CD25- T cell-treated group.	Creatinine	10-20	interleukin 2 receptor subunit alpha	Homo sapiens	73-77
24621976-9	2013	Urocortin-2 reduced urine volume and creatinine clearance during infusion but these returned to above baseline level in the 8 h after infusion.	Creatinine	37-47	urocortin 2	Homo sapiens	0-11
24144740-8	2013	In patients with chronic rejections, the serum creatinine levels were significantly higher in MICA(+) than in MICA(-) cases (P&lt;0.05).	Creatinine	47-57	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
24144740-8	2013	In patients with chronic rejections, the serum creatinine levels were significantly higher in MICA(+) than in MICA(-) cases (P&lt;0.05).	Creatinine	47-57	MHC class I polypeptide-related sequence A	Homo sapiens	110-114
24004120-6	2013	The net reclassification improvement with the measurement of cystatin C, as compared with creatinine, was 0.23 (95% confidence interval [CI], 0.18 to 0.28) for death and 0.10 (95% CI, 0.00 to 0.21) for end-stage renal disease.	Creatinine	90-100	cystatin C	Homo sapiens	61-71
30286468-5	2018	Moreover, glomerular C3c and C9 and tubular MASP-2 and Collectin-11 expression in zero-biopsies significantly correlated with serum creatinine at diagnosis of DGF, TCMR or ABMR.	Creatinine	132-142	collectin subfamily member 11	Homo sapiens	55-67
24019901-11	2013	In summary, obese nephron-deficient GDNF HET mice were able to maintain the high creatinine clearances of obese WT mice but at the expense of higher MAP and greater renal fibrosis.	Creatinine	81-91	glial cell line derived neurotrophic factor	Mus musculus	36-40
23681145-8	2013	Mice treated with anti-miR-21 and ischemia-reperfusion injury showed significantly higher serum creatinine than antiscrambled oligonucleotides-treated mice, 24 h after ischemia-reperfusion (1.37 +- 0.28 vs. 0.81 +- 0.14 mg/dl; n = 5; P &lt; 0.05).	Creatinine	96-106	microRNA 21a	Mus musculus	23-29
23706287-12	2013	CONCLUSION: The concentration of cystatin C is strongly associated with long-term all-cause and cardiovascular mortality in patients referred to coronary angiography, irrespective of creatinine-based renal function.	Creatinine	183-193	cystatin C	Homo sapiens	33-43
23922826-6	2013	Although no significant differences were revealed in renal morphology and function between Osx heterozygotes and wild-type under normoxic conditions, recovery of kidneys after ischemic damage was remarkably delayed in Osx heterozygotes, as indicated by elevated blood urea nitrogen and creatinine levels, and by morphological alterations consistent with acute tubular necrosis.	Creatinine	286-296	Sp7 transcription factor	Homo sapiens	218-221
23876053-0	2013	Glomerular filtration rate (GFR) determination via individual kinetics of the inulin-like polyfructosan sinistrin versus creatinine-based population-derived regression formulae.	Creatinine	121-131	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	28-31
23876053-1	2013	BACKGROUND: In renal patients estimation of GFR is routinely done by means of population-based formulae using serum creatinine levels.	Creatinine	116-126	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	44-47
23876053-10	2013	But in creatinine-blind ranges [GFR above 60 (ml/min)/1.73 m2] eGFR values are unreliable and should be replaced by clinically and physiologically suitable methods for mGFR determination.	Creatinine	7-17	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	32-35
23852907-4	2013	AIM: The present study is performed with the aim to explore the relationship between CIn and BUN/creatinine ratio.	Creatinine	97-107	pyridoxal phosphatase	Homo sapiens	85-88
23407373-10	2013	Systolic BP&gt;140 mm Hg or diastolic BP&gt;90 mm Hg was significantly associated with progression using a cystatin C-based (odds ratio (OR), 2.49; 95% confidence interval (CI), 1.12-5.52) or the combined equation (OR, 2.07; 95% CI, 1.16-3.69), but not when using creatinine after adjustment for covariates.	Creatinine	264-274	cystatin C	Homo sapiens	107-117
23042433-8	2013	Serum BAFF levels were significantly positively correlated with estimated glomerular filtration rate and serum creatinine.	Creatinine	111-121	TNF superfamily member 13b	Homo sapiens	6-10
23429977-8	2013	CysC levels were negatively correlated with gestational age at birth, and PCA (P &lt; 0.001), while positively correlated with postnatal age and serum creatinine (P &lt; 0.001).	Creatinine	151-161	cystatin C	Homo sapiens	0-4
22212518-8	2013	RESULTS: The incidence of cystatin C-based CIN was 28.5% (n = 14) in NAC and 23.4% (n = 15) in control group (p = 0.663) and serum creatinine-based CIN was 12.2% (n = 6) in NAC and 17.2% (n = 11) in control group (P= 0.468).	Creatinine	131-141	cystatin C	Homo sapiens	26-36
21786387-13	2013	Increased NAG activity was observed when Cd in urine reached 1.0 mug Cd/g creatinine and was also affected by age, hypertension, and diabetes mellitus.	Creatinine	74-84	O-GlcNAcase	Homo sapiens	10-13
24072151-11	2013	Administration of RHE significantly decreased changes in serum creatinine, BUN, and malondialdehyde levels in male rats, but not in females.	Creatinine	63-73	factor interacting with PAPOLA and CPSF1	Homo sapiens	18-21
29643901-8	2018	MIOX/creatinine at hour 6 was lower than the value calculated at hour 24 (p = 0.0348).	Creatinine	5-15	myo-inositol oxygenase	Homo sapiens	0-4
23910589-8	2013	Areas under the receiver operator characteristic curves for CKD-EPI CysC and CKD-EPI creatinine-CysC equations were significantly higher than that for the MDRD equation, especially in patients with &gt;60 mL min(-1) 1.73 m(-2).	Creatinine	85-95	cystatin C	Homo sapiens	96-100
23674604-5	2013	Treatment of 5/6 nephrectomized rats with AMG 416 resulted in dramatic improvements in their metabolic profile, including lower PTH and serum creatinine levels, reduced amounts of vascular calcification, attenuated parathyroid hyperplasia, and greater expression of the parathyroid gland regulators CaSR, vitamin D receptor, and FGF23 receptor compared with vehicle-treated animals.	Creatinine	142-152	amelogenin X-linked	Homo sapiens	42-45
23503750-7	2013	RESULTS: The urinary plasminogen-plasmin/creatinine ratio was 226 [95 % confidence interval (CI) 130-503] mug/mmol in nephrotic urine versus 9.5 (95 % CI 8-12) mug/mmol at remission (p &lt; 0.001).	Creatinine	41-51	plasminogen	Homo sapiens	21-28
22878979-1	2013	BACKGROUND: Serum cystatin C has been recognized as a surrogate marker for serum creatinine (SCr).	Creatinine	81-91	cystatin C	Homo sapiens	18-28
25340125-12	2013	CONCLUSION: The association of vasculopathy with serum creatinine and amount of proteinuria further support the role of vasculopathy in aggravation of IgAN.	Creatinine	55-65	IGAN1	Homo sapiens	151-155
23541229-4	2013	RESULTS: Mice deficient in TLR2, but not TLR9, were protected from renal I/R injury with less tubular damage, decreased cytokine production, and lower serum creatinine and urea levels than wild-type mice.	Creatinine	157-167	toll-like receptor 2	Mus musculus	27-31
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Creatinine	116-126	tumor necrosis factor-like	Rattus norvegicus	151-154
23828708-7	2013	Visfatin levels increased with the progression of renal dysfunction and inversely related to creatinine clearance (Ccr) in non-dialyzed patients (r=-0.415, P&lt;0.05).	Creatinine	93-103	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
23054318-7	2013	Inferior creatinine clearance was observed in dTAC-IL2-RA Group compared to TAC-IL2-RA and TAC-No Groups at months 1 (41.6 vs. 49.9 vs. 44.8 mL/min, p = 0.004), 3 (49.8 vs. 57.2 vs. 53.5 mL/min, p = 0.017), and 6 (53.1 vs. 61.8 vs. 57.0 mL/min, p = 0.001).	Creatinine	9-19	interleukin 2 receptor subunit alpha	Homo sapiens	51-57
27206415-9	2018	Cystatin C was also significantly associated with both the NYHA classification and the E/A ratio even after adjustment for the creatinine clearance rate (CCr).	Creatinine	127-137	cystatin C	Homo sapiens	0-10
29255279-7	2017	The miR-21/creatinine in the urine from day 4 was significantly higher than that of the controls and was detected earlier than urinary albumin.	Creatinine	11-21	microRNA 21a	Mus musculus	4-10
29431364-7	2017	Serum cystatin C is a novel biomarker that is most useful when a false-positive decreased estimated glomerular filtration rate calculated from serum creatinine is suspected.	Creatinine	149-159	cystatin C	Homo sapiens	6-16
28594240-7	2017	After regular feeding for 24 months or inducing type 2 diabetes, Ddah1-/- mice had higher serum creatinine levels than wild-type (WT) mice.	Creatinine	96-106	dimethylarginine dimethylaminohydrolase 1	Mus musculus	65-70
28867309-10	2017	Additionally, patients with BAFF levels above detected median even displayed impaired creatinine values as well as an induced eGFR slope up to month 48 after transplantation.	Creatinine	86-96	TNF superfamily member 13b	Homo sapiens	28-32
29725637-0	2018	Cystatin C Predicts Renal Recovery Earlier Than Creatinine Among Patients With Acute Kidney Injury.	Creatinine	48-58	cystatin C	Homo sapiens	0-10
29725637-3	2018	This retrospective study aimed to determine the temporal trend between creatinine and cystatin C in acute kidney injury.	Creatinine	71-81	cystatin C	Homo sapiens	86-96
29725637-13	2018	Conclusion: In summary, cystatin C decreases before creatinine in most hospitalized patients with acute kidney injury.	Creatinine	52-62	cystatin C	Homo sapiens	24-34
28544332-5	2017	FGF2 treatment greatly alleviated I/R-induced acute renal dysfunction and largely blunted I/R-induced elevation in serum creatinine and blood urea nitrogen, and also the number of TUNEL-positive tubular cells in the kidney.	Creatinine	121-131	fibroblast growth factor 2	Rattus norvegicus	0-4
22951018-9	2013	Amounts of platelet-derived CD42a(+) particles from patients with sepsis-related renal injury correlated negatively with actual blood urea nitrogen and creatinine concentrations.	Creatinine	152-162	glycoprotein IX platelet	Homo sapiens	28-33
23841035-0	2013	Relationship between serum cystatin C and creatinine or dialysis adequacy in patients on chronic maintenance hemodialysis.	Creatinine	42-52	cystatin C	Homo sapiens	27-37
23551676-8	2013	In multivariate regression analysis YKL-40 was associated with creatinine, serum albumin and hs-CRP concentrations after adjustments with covariates.	Creatinine	63-73	chitinase 3 like 1	Homo sapiens	36-42
23473526-8	2013	The independent risk factors for UTI with concomitant bacteremia in multivariate analysis were immunosuppression with tacrolimus (adjusted odds ratio [AOR] 3.17; 95% confidence interval [CI] 1.29-7.75; P = 0.011) and baseline serum creatinine level &gt;1.3 mg/dL before first UTI (AOR 2.55; 95% CI 1.02-6.36; P = 0.045).	Creatinine	232-242	alpha-1-microglobulin/bikunin precursor	Homo sapiens	33-36
23473526-10	2013	CONCLUSION: From this study, we found that E coli tends to have resistance to commonly used empirical antibiotics in this modern era and that patients who use the immunosuppressant tacrolimus and have baseline serum creatinine level &gt;1.3 mg/dL before their first UTI have a tendency to suffer from concomitant bacteremia and even sepsis.	Creatinine	216-226	alpha-1-microglobulin/bikunin precursor	Homo sapiens	266-269
23275574-1	2013	BACKGROUND: As with creatinine, cystatin C can be incorporated into a formula to estimate the glomerular filtration rate (GFR).	Creatinine	20-30	cystatin C	Homo sapiens	32-42
22837540-0	2013	Stable cystatin C serum levels confirm normal renal function in patients with dronedarone-associated increase in serum creatinine.	Creatinine	119-129	cystatin C	Homo sapiens	7-17
22989558-7	2013	A significant positive correlation between serum creatinine and TGF-beta1 levels was found in CKD cats.	Creatinine	49-59	transforming growth factor beta 1	Felis catus	64-73
23144053-9	2013	Urinary ACE2 concentrations appeared to correlate with HOMA-IR, fasting blood glucose, triglyceride, high-sensitivity C-reactive protein, serum creatinine, urinary ACR, and systolic blood pressure (all P&lt;0.05).	Creatinine	144-154	angiotensin converting enzyme 2	Homo sapiens	8-12
23016830-1	2013	AIM: To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.	Creatinine	82-92	cystatin C	Homo sapiens	39-49
23016830-1	2013	AIM: To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.	Creatinine	82-92	cystatin C	Homo sapiens	51-55
23016830-1	2013	AIM: To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.	Creatinine	94-96	cystatin C	Homo sapiens	39-49
23016830-1	2013	AIM: To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.	Creatinine	141-143	cystatin C	Homo sapiens	39-49
28417217-9	2017	Serum CyC level significantly correlated with B2M, urea and creatinine levels in both the LFH and HFH groups, whereas its RR significantly correlated with the RRs of urea, creatinine, and B2M in the HFH group.	Creatinine	60-70	cystatin C	Homo sapiens	6-9
28417217-9	2017	Serum CyC level significantly correlated with B2M, urea and creatinine levels in both the LFH and HFH groups, whereas its RR significantly correlated with the RRs of urea, creatinine, and B2M in the HFH group.	Creatinine	172-182	cystatin C	Homo sapiens	6-9
28979926-5	2017	RESULTS: Urinary KIM-1 and ANG concentrations were strongly correlated to each other and were significantly and independently associated with cold ischemia time, delayed graft function, and plasma creatinine 10 days after transplantation, indicating that these markers reflect the severity of IRI.	Creatinine	197-207	angiogenin	Homo sapiens	27-30
28318752-7	2017	CSE deficient mice, compared to wild-type mice, showed a significant attenuation of the burn-induced elevation in circulating alkaline aminotransferase and blood urea nitrogen and creatinine levels, indicative of protective effects of CSE deficiency against burn-induced hepatic, and renal functional impairment.	Creatinine	180-190	cystathionase (cystathionine gamma-lyase)	Mus musculus	0-3
23034938-6	2013	Our results indicate that in the glomeruli of mice treated with ADR, ZO-2 overexpression increases the amount of phosphorylated beta-catenin, inhibits the expression of the transcription factor snail, prevents nephrin and podocalyxin loss, reduces podocyte effacement and massive fusions, restrains proteinuria, and supports urea and creatinine clearance.	Creatinine	334-344	tight junction protein 2	Mus musculus	69-73
24356308-7	2013	RESULTS: CAF concentrations strongly correlated with creatinine (r = 0.86 (cWP), r = 0.74 (cBP)) and eGFR (MDRD) (r = 0.86 (cWP), r = 0.77 (cBP)).	Creatinine	53-63	lysine acetyltransferase 2B	Homo sapiens	9-12
24356308-10	2013	Stable concentrations were reached 1-3 months after transplantation for CAF and creatinine (CAF 145.1 (6.7-851.0) pM; creatinine 1.6 (0.7-8.0) mg/dl).	Creatinine	80-90	lysine acetyltransferase 2B	Homo sapiens	92-95
24356308-11	2013	CAF concentrations at POD 1-3 were significantly associated with DGF and outperformed creatinine in early detection of DGF (area under the curve (AUC) CAF 80.7% (95% CI 72.3-89.1%) vs. AUC creatinine 71.3% (95% CI 61.8-81.1%), p = 0.061).	Creatinine	189-199	lysine acetyltransferase 2B	Homo sapiens	0-3
23220801-5	2013	The Cys-C ratio (Cys-C level on the third postoperative day/preoperative level) was positively correlated with Cr ratio (R=0.57, P&lt;0.001).	Creatinine	111-113	cystatin C	Homo sapiens	4-9
23220801-5	2013	The Cys-C ratio (Cys-C level on the third postoperative day/preoperative level) was positively correlated with Cr ratio (R=0.57, P&lt;0.001).	Creatinine	111-113	cystatin C	Homo sapiens	17-22
22422580-8	2013	Cystatin C was correlated with Apnea Hypopnea Index (AHI), Oxygen Desaturation Index, hsCRP, creatinine, and estimated glomerular filtration rate (r = 0.319, 0.279, 0.321, 0.233, -0.241, p = 0.001, 0.005, 0.001, 0.021, 0.017, respectively).	Creatinine	93-103	cystatin C	Homo sapiens	0-10
28700526-9	2017	In addition, in the HSPN patients, the urinary MIF was positively associated with urinary microalbumin and 24-hour proteinuria but no association with serum creatinine and blood urea nitrogen.	Creatinine	157-167	macrophage migration inhibitory factor	Homo sapiens	47-50
28492915-9	2017	The increases in long-chain acylarnitine metabolites and short-chain dicarboxylacylcarnitines correlated with increases in endothelin-1 and creatinine/cystatin C, respectively.	Creatinine	140-150	cystatin C	Homo sapiens	151-161
28210837-10	2017	CONCLUSIONS: Increased expressions of TLR-3, TLR-4 and CD80 mRNA and the level of urinary CD80/creatinine could be useful markers to differentiate patients of SSNS in relapse from those with SRNS.	Creatinine	95-105	CD80 molecule	Homo sapiens	90-94
28693441-0	2017	CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations.	Creatinine	8-18	cystatin C	Homo sapiens	19-29
28706983-9	2017	High FOXP3 expression was also associated with lower level of serum creatinine at 1 year.	Creatinine	68-78	forkhead box P3	Homo sapiens	5-10
28126239-11	2017	MEASUREMENTS: eGFR was calculated using the CKD-EPI creatinine (eGFRcr), cystatin C (eGFRcys), and creatinine-cystatin C (eGFRcr-cys) equations.	Creatinine	99-109	cystatin C	Homo sapiens	110-120
24409655-1	2013	BACKGROUND: Serum cystatin C has been proposed as an endogenous marker of glomerular filtration rate (GFR) because it shows a correlation with the albumin to creatinine ratio (ACR) in diabetic nephropathy.	Creatinine	158-168	cystatin C	Homo sapiens	18-28
23689573-13	2013	The prognosis of FSGS was correlated with the amount of proteinuria, the level of serum creatinine, and the severity of glomerular sclerosis and tubulointerstitial lesions.	Creatinine	88-98	actinin alpha 4	Homo sapiens	17-21
22986489-5	2013	There was a significant positive association between YKL-40 levels and urinary albumin creatinine ratio (UACR) (r = 0.226, p = 0.013).	Creatinine	87-97	chitinase 3 like 1	Homo sapiens	53-59
28438765-7	2017	At delivery, A1M concentrations were higher in the PE group than in the GH and NC groups as an A1M/creatinine ratio &gt;13 (66.7, 8.3, and 35%, respectively, P = 0.01).	Creatinine	99-109	alpha-1-microglobulin/bikunin precursor	Homo sapiens	13-16
28414753-8	2017	Moreover, CCL18 levels in effluent at year 3 of PD were independently associated with a risk of PMF development, adjusted for the classical (water and creatinine) peritoneal transport parameters.	Creatinine	151-161	C-C motif chemokine ligand 18	Homo sapiens	10-15
23498789-12	2013	In addition, FSP and CCL21 expression positively correlated with serum creatinine levels.	Creatinine	71-81	C-C motif chemokine ligand 21	Homo sapiens	21-26
23341711-0	2013	Serum cystatin C is a major predictor of vancomycin clearance in a population pharmacokinetic analysis of patients with normal serum creatinine concentrations.	Creatinine	133-143	cystatin C	Homo sapiens	6-16
23341711-7	2013	The use of serum cystatin C as marker of vancomycin clearance for more accurate predictions of serum vancomycin concentrations could be useful, particularly among patients with normal serum creatinine concentrations.	Creatinine	190-200	cystatin C	Homo sapiens	17-27
23108375-5	2013	Using a transcriptomics data set of patients with proteinuric kidney diseases we found that low levels of SOCS-3 RNA were associated with high-serum creatinine values in the long-term follow-up, which suggested a role of SOCS-3, regulated signaling in progression of chronic kidney disease.	Creatinine	149-159	suppressor of cytokine signaling 3	Homo sapiens	106-112
23108375-5	2013	Using a transcriptomics data set of patients with proteinuric kidney diseases we found that low levels of SOCS-3 RNA were associated with high-serum creatinine values in the long-term follow-up, which suggested a role of SOCS-3, regulated signaling in progression of chronic kidney disease.	Creatinine	149-159	suppressor of cytokine signaling 3	Homo sapiens	221-227
23530579-2	2013	We aimed to evaluate the correlation of serum cystatin C levels with the serum creatinine levels and GFR calculated by Cockcroft-Gault and modification of diet in renal disease (MDRD) formulations in the patients who received cisplatin-based chemotherapy.	Creatinine	79-89	cystatin C	Homo sapiens	46-56
23530579-7	2013	RESULTS: A statistically significant linear correlation was found between the serum levels of cystatin C and creatinine prior to the chemotherapy (r = 0.42, p = 0.013).	Creatinine	109-119	cystatin C	Homo sapiens	94-104
27821630-6	2017	Idh2 gene deletion exacerbated the I/R-induced increase in plasma creatinine and BUN levels and the histologic evidence of tubule injury, and augmented the reduction of NADPH levels and the increase in oxidative stress observed in the kidney after I/R.	Creatinine	66-76	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	0-4
28571128-0	2017	Association Between Serum Cystatin C and Creatinine in Chronic Kidney Disease Subjects Attending a Tertiary Health Care Centre.	Creatinine	41-51	cystatin C	Homo sapiens	26-36
28340079-6	2017	Results: Since cystatin C and creatinine are inversely related to mGFR, cystatin C - 1 and creatinine - 1 were used.	Creatinine	30-40	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	66-70
28340830-6	2017	RESULTS: All recurrent IgAN patients presented with renal dysfunction (mean serum creatinine, 1.62 +- 0.39 mg/dL) and detectable proteinuria at the time of diagnosis.	Creatinine	82-92	IGAN1	Homo sapiens	23-27
28340561-6	2017	CIN severity was determined by measurement of urinary neutrophil gelatinase-associated lipocalin (NGAL):creatinine at specific time intervals.	Creatinine	104-114	lipocalin 2	Mus musculus	98-102
28340561-10	2017	RESULTS: Urinary NGAL:creatinine ratio was significantly lower at 48 h with a 44% and 62% (204.3mug/mmol versus 533.6mug/mmol, p = 0.049) reduction in the low and high dose AA groups, respectively.	Creatinine	22-32	lipocalin 2	Mus musculus	17-21
28271689-8	2017	MRA demonstrated that serum CysC levels correlated significantly with serum creatinine (Cr), high density lipoprotein (HDL-C), alkaline phosphatase (ALP), albumin (ALB), and uric acid (UA) concentrations, although their relationships were less prominent than those of gender or age.	Creatinine	76-86	cystatin C	Homo sapiens	28-32
23964786-5	2013	However, MGN patients with A-G haplotype were susceptible for decreased creatinine clearance rate and for seriously tubule-interstitial fibrosis.	Creatinine	72-82	helt bHLH transcription factor	Homo sapiens	9-12
24872960-6	2013	In PIH cystatin C was significantly higher, 1.25 +- 0.9 unlike creatinine, 0.67 +- 0.14 and uric acid, 4.30 +- 1.0.	Creatinine	63-73	cystatin C	Homo sapiens	7-17
22842844-8	2012	The creatinine-cystatin C equation was significantly more accurate than the cystatin C equation, and there was a trend toward greater accuracy than the creatinine equation.	Creatinine	4-14	cystatin C	Homo sapiens	15-25
23115401-10	2012	The odds ratio was 2.2 for elevated BNP levels for women with an AHI of 5-14.9 in relation to women with an AHI &lt; 5, 3.1 for women with an AHI of 15-29.9, and 4.6 for women with an AHI &gt;= 30 after adjustment for age, body mass index, systolic blood pressure, antihypertensive drugs, and creatinine.	Creatinine	293-303	natriuretic peptide B	Homo sapiens	36-39
22938661-0	2012	[Value of creatinine clearance rate estimated based on serum cystatin C in patients with acute kidney injury].	Creatinine	10-20	cystatin C	Homo sapiens	61-71
22938661-1	2012	OBJECTIVE: To investigate diagnostic value of creatinine clearance rate (CCr) based on serum cystatin C (SCys C) in acute kidney injury (AKI), and whether it could predict the need for renal replacement therapy (RRT).	Creatinine	46-56	cystatin C	Homo sapiens	93-103
22669842-5	2012	Pkhd1 is protected from increased blood pressure as well as elevated plasma creatinine and blood urea nitrogen levels.	Creatinine	76-86	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Rattus norvegicus	0-5
28271689-8	2017	MRA demonstrated that serum CysC levels correlated significantly with serum creatinine (Cr), high density lipoprotein (HDL-C), alkaline phosphatase (ALP), albumin (ALB), and uric acid (UA) concentrations, although their relationships were less prominent than those of gender or age.	Creatinine	88-90	cystatin C	Homo sapiens	28-32
28271689-11	2017	In addition to gender and age, serum Cr, HDL-C, ALP, ALB, and UA also influenced serum CysC levels.	Creatinine	37-39	cystatin C	Homo sapiens	87-91
28069720-7	2017	Because creatinine is also a substrate of OCT2, MATE1, and MATE2-K, creatinine clearance likely overestimates filtration clearance, whereas the calculated 1-NMN secretion clearance is likely underestimated.	Creatinine	8-18	solute carrier family 47 member 2	Homo sapiens	59-66
22607624-7	2012	Given elevated cystatin C (&gt;=1.30 mg/mL), mortality risk was further increased by high serum creatinine, high abdominal visceral fat density, and smoking history (2.52&lt;=HR &lt;=3.73).	Creatinine	96-106	cystatin C	Homo sapiens	15-25
22834778-9	2012	Multiple linear regression analyses demonstrated that with NT pro-BNP levels as the dependent variable, NT pro-BNP levels were positively correlated with CK-MB (beta = 0.182, P = 0.024) and creatinine levels (beta = 0.281, P = 0.001).	Creatinine	190-200	natriuretic peptide B	Homo sapiens	111-114
22762315-7	2012	In the validation data set, the creatinine-cystatin C equation performed better than equations that used creatinine or cystatin C alone.	Creatinine	32-42	cystatin C	Homo sapiens	43-53
22762315-7	2012	In the validation data set, the creatinine-cystatin C equation performed better than equations that used creatinine or cystatin C alone.	Creatinine	105-115	cystatin C	Homo sapiens	43-53
22762315-11	2012	CONCLUSIONS: The combined creatinine-cystatin C equation performed better than equations based on either of these markers alone and may be useful as a confirmatory test for chronic kidney disease.	Creatinine	26-36	cystatin C	Homo sapiens	37-47
23200959-6	2013	RESULTS: Urine geometric mean KIM-1 levels (ng/mg creatinine) were significantly higher in VUR patients than in healthy controls (P=.018).	Creatinine	50-60	VUR	Homo sapiens	91-94
28069720-7	2017	Because creatinine is also a substrate of OCT2, MATE1, and MATE2-K, creatinine clearance likely overestimates filtration clearance, whereas the calculated 1-NMN secretion clearance is likely underestimated.	Creatinine	68-78	solute carrier family 47 member 2	Homo sapiens	59-66
28207726-7	2017	Increasing age, dialysis and high serum creatinine were associated with poorer survival on multivariate Cox regression analyses (hazard ratio of 1.035, 4.216 and 1.930 respectively with p-values of 0.018, &lt;0.001 and 0.046).	Creatinine	40-50	cytochrome c oxidase subunit 8A	Homo sapiens	104-107
27836731-5	2017	RESULTS: Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and log(hemoglobin A1c) showed that log(OGN) was negatively associated with BMD at the femoral neck (beta=-0.17, p=0.014).	Creatinine	97-107	osteoglycin	Homo sapiens	149-152
28181906-7	2017	RESULTS: Urine activity of arylsulfatase A in graft donors correlated positively with creatinine clearance in graft recipients after transplantation: significantly after 30 days (Rs=0.38, p=0.004) and after 3 years (Rs=0.38, p=0.03), and with borderline significance after 14 days (Rs=0.25, p=0.08) and after one year (Rs=0.23, p=0.07).	Creatinine	86-96	arylsulfatase A	Homo sapiens	27-42
27722961-15	2017	However, for patients with protein-creatinine ratio &gt;500 mg/g (albumin-creatinine ratio &gt; 300 mg/g), with or without diabetes, lower SBP target should be proposed for renal protection aiming SBP &lt; 130 mmHg as recommended by KDIGO guidelines.In patients at low or intermediate risk, without cardiovascular disease, SBP should start to be treated when SBP is above 140 mmHg, and when treated, target BP should be less than 140 mmHg as reported by HOPE-3 trial.	Creatinine	74-84	selenium binding protein 1	Homo sapiens	139-142
28513288-5	2017	Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine.	Creatinine	121-131	cystatin C	Homo sapiens	62-72
24171321-0	2013	Hydrogen/hydride ion relay--a mechanism for early electron transfer in cytochrome c oxidases.	Creatinine	9-16	LOC104968582	Bos taurus	71-83
22809763-9	2012	RESULTS: Overall, serum creatinine level detected more cases of AKI than cystatin C level: 35% developed a &gt;=25% increase in serum creatinine level, whereas only 23% had a &gt;=25% increase in cystatin C level (P &lt; 0.001).	Creatinine	24-34	cystatin C	Homo sapiens	196-206
22809763-9	2012	RESULTS: Overall, serum creatinine level detected more cases of AKI than cystatin C level: 35% developed a &gt;=25% increase in serum creatinine level, whereas only 23% had a &gt;=25% increase in cystatin C level (P &lt; 0.001).	Creatinine	134-144	cystatin C	Homo sapiens	73-83
22349874-7	2012	Cystatin C levels were correlated only with age, urea level, and creatinine level (p &lt; 0.05).	Creatinine	65-75	cystatin C	Homo sapiens	0-10
22811357-10	2012	RESULTS: Levels of Cin were highly correlated with those of endogenous creatinine clearance (Ccr) (R(2) = 0.7585) and eGFR (R(2) = 0.5659).	Creatinine	71-81	pyridoxal phosphatase	Homo sapiens	19-22
22811360-0	2012	The clinical significance of serum cystatin C in critically ill newborns with normal serum creatinine.	Creatinine	91-101	cystatin C	Homo sapiens	35-45
22811360-1	2012	BACKGROUND: The aim of this study is to evaluate the clinical significance of cystatin C(CysC) in the newborns who show normal serum creatinine (Cr) and who are in an intensive care unit.	Creatinine	133-143	cystatin C	Homo sapiens	78-88
22811360-1	2012	BACKGROUND: The aim of this study is to evaluate the clinical significance of cystatin C(CysC) in the newborns who show normal serum creatinine (Cr) and who are in an intensive care unit.	Creatinine	145-147	cystatin C	Homo sapiens	78-88
22252480-4	2012	RESULTS: In a sex, BMI, smoking habit, physical activity level and serum creatinine adjusted model, low-density lipoprotein-cholesterol (LDL-C) appears to be significantly related to SBP (P &lt; 0.001), DBP (P = 0.026), and pulse pressure (PP) (P &lt; 0.001).	Creatinine	73-83	selenium binding protein 1	Homo sapiens	183-186
21725924-8	2012	Statistical analysis revealed positive correlations between Snai1/vimentin double positive cell numbers and proteinuria and creatinine in IgAN.	Creatinine	124-134	IGAN1	Homo sapiens	138-142
21651460-9	2012	Urinary NAG was measured using the colorimetrical method and expressed as units per gram of creatinine (U/gCr).	Creatinine	92-102	O-GlcNAcase	Homo sapiens	8-11
22740900-1	2012	The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive protein (CRP) and disease extent in patients with lung cancer.	Creatinine	113-123	cystatin C	Homo sapiens	81-91
22740900-1	2012	The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive protein (CRP) and disease extent in patients with lung cancer.	Creatinine	113-123	cystatin C	Homo sapiens	93-98
22740900-1	2012	The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive protein (CRP) and disease extent in patients with lung cancer.	Creatinine	125-128	cystatin C	Homo sapiens	81-91
29286938-0	2017	The relationship between body weight, cystatin C and serum creatinine in neonates.	Creatinine	59-69	cystatin C	Homo sapiens	38-48
22966455-6	2012	There was a strong correlation between NAG/creatinine ratio and albumin/creatinine ratio (r = 0.74, P &lt; 0.001).	Creatinine	72-82	O-GlcNAcase	Homo sapiens	39-42
22966455-7	2012	A multivariate linear regression model showed a significant linear relationship between NAG/creatinine ratio and albumin/creatinine ratio after adjusting for the effect of blood pressure, age, sex, and serum creatinine.	Creatinine	92-102	O-GlcNAcase	Homo sapiens	88-91
22966455-7	2012	A multivariate linear regression model showed a significant linear relationship between NAG/creatinine ratio and albumin/creatinine ratio after adjusting for the effect of blood pressure, age, sex, and serum creatinine.	Creatinine	121-131	O-GlcNAcase	Homo sapiens	88-91
22966455-7	2012	A multivariate linear regression model showed a significant linear relationship between NAG/creatinine ratio and albumin/creatinine ratio after adjusting for the effect of blood pressure, age, sex, and serum creatinine.	Creatinine	121-131	O-GlcNAcase	Homo sapiens	88-91
22966455-8	2012	The strong association found between albumin/creatinine ratio and NAG/creatinine ratio perhaps indicates the need for further investigation of the clinical utility of NAG/creatinine ratio as a screening tool for early nephropathy in African diabetics.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	66-69
22966455-8	2012	The strong association found between albumin/creatinine ratio and NAG/creatinine ratio perhaps indicates the need for further investigation of the clinical utility of NAG/creatinine ratio as a screening tool for early nephropathy in African diabetics.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	167-170
23158800-9	2012	(3) In UUO group, the level of NGAL was positively correlated with the serum levels of TNF-alpha and serum creatinine (r = 0.910, 0.673, P &lt; 0.01).	Creatinine	107-117	lipocalin 2	Rattus norvegicus	31-35
27504800-7	2017	In serum, elevated levels of blood urea nitrogen and creatinine were reduced in anti-OPN Ab-treated mice compared with vehicle.	Creatinine	53-63	secreted phosphoprotein 1	Mus musculus	85-88
27921376-8	2016	Analysis of the 12 studies that investigated serum creatinine indicated that serum cystatin C was more accurate than serum creatinine for the diagnosis of renal dysfunction.	Creatinine	51-61	cystatin C	Homo sapiens	83-93
27921376-9	2016	Our results indicate that serum cystatin C is an effective index in diagnosing renal dysfunction comparing serum creatinine, serum cystatin C is more sensitivity for evaluation of renal function in diabetic patients.	Creatinine	113-123	cystatin C	Homo sapiens	32-42
29142952-9	2017	CysC was positively correlated with creatinine (P &lt; 0.001), estimated glomerular filtration rate (P &lt; 0.001), and urinary beta-trace protein (P = 0.01).	Creatinine	36-46	cystatin C	Homo sapiens	0-4
23257682-8	2012	ACE2 activity correlated positively with serum creatinine (r = 0.27), serum urea (r = 0.29), age (r = 0.24), aspartate transaminase (r = 0.39), alanine transaminase (r = 0.48), gamma-glutamyl transferase (gamma-GT) (r = 0.52), age (r = 0.24), and glycosylated hemoglobin (r = 0.19) (p &lt; 0.05).	Creatinine	47-57	angiotensin converting enzyme 2	Homo sapiens	0-4
23257682-9	2012	By multiple regression analysis, age, serum creatinine, and serum gamma-GT were independent predictors of serum ACE2 activity (r = 0.66, p &lt; 0.001).	Creatinine	44-54	angiotensin converting enzyme 2	Homo sapiens	112-116
27430168-6	2016	In a multivariate Cox regression model, it was demonstrated that serum creatinine level (P = 0.019) and heart rate (P = 0.022) were significant risk factors for mortality.	Creatinine	71-81	cytochrome c oxidase subunit 8A	Homo sapiens	18-21
23635481-7	2012	After adjustment for sex, race, preexisting chronic kidney disease and APACHE II score, the KLK1 risk-allele (I or G) carrier state was associated with the composite of &gt;=2-fold increase in serum creatinine, oliguria, or dialysis requirement (adjusted OR 2.71; 95% CI 1.14, 6.44; p = 0.02).	Creatinine	199-209	kallikrein 1	Homo sapiens	92-96
23635481-8	2012	The KLK1 risk-allele carrier state was also marginally associated with the composite of &gt;=2-fold increase in serum creatinine, oliguria, dialysis requirement, or in-hospital death (adjusted OR 2.33; 95% CI 0.98, 5.52; p = 0.06).	Creatinine	118-128	kallikrein 1	Homo sapiens	4-8
27038523-1	2016	Topiroxostat, a xanthine oxidoreductase (XOR) inhibitor, has been shown to decrease the urinary albumin-to-creatinine ratio compared with placebo in hyperuricemic patients with stage 3 chronic kidney disease.	Creatinine	107-117	xanthine dehydrogenase	Homo sapiens	41-44
22247903-4	2011	RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR).	Creatinine	253-263	cystatin C	Homo sapiens	155-165
26362442-3	2016	Enzymatically measured Ccr was recently found to be much higher than Cin because of the tubular secretion of creatinine (Cr).	Creatinine	109-119	pyridoxal phosphatase	Homo sapiens	69-72
22136618-1	2011	OBJECTIVES: To investigate the inter-relationships of osteoprotegerin (OPG) with albumin to creatinine ratio (ACR) and asymmetric dimethylargine (ADMA) in hypertensive patients.	Creatinine	92-102	TNF receptor superfamily member 11b	Homo sapiens	54-69
22136618-1	2011	OBJECTIVES: To investigate the inter-relationships of osteoprotegerin (OPG) with albumin to creatinine ratio (ACR) and asymmetric dimethylargine (ADMA) in hypertensive patients.	Creatinine	92-102	TNF receptor superfamily member 11b	Homo sapiens	71-74
26362442-3	2016	Enzymatically measured Ccr was recently found to be much higher than Cin because of the tubular secretion of creatinine (Cr).	Creatinine	121-123	pyridoxal phosphatase	Homo sapiens	69-72
26880295-7	2016	The effect of high BNP levels on the risk of all-cause mortality was significantly greater in the subgroup of patients with a non-hypertensive etiology, low creatinine levels (&lt;1.3mg/dL), and high sodium levels (&gt;=135mEq/L) than in those without these factors (P=0.024, P&lt;0.001, and P&lt;0.001 for the interaction, respectively).	Creatinine	157-167	natriuretic peptide B	Homo sapiens	19-22
27273597-7	2016	Plasma Sema3A levels correlated positively with the retinal nonperfusion area size (r = 0.844, P = 0.004), total macular volume (r = 0.765, P = 0.005), and the urine albumin-to-creatinine ratio (r = 0.752, P &lt; 0.001).	Creatinine	177-187	semaphorin 3A	Homo sapiens	7-13
22845020-7	2012	Furthermore, blood urea nitrogen (BUN) and plasma creatinine levels, indicative of nephrotoxicity, were also found to be significantly lesser for developed PLN formulation as compared to free drug and Fungizone while comparable to that of Fungisome.	Creatinine	50-60	phospholamban	Homo sapiens	156-159
22681753-5	2012	hEPCR mice were protected in a model of warm renal ischemia reperfusion injury compared to wild type (WT) littermates (mean serum creatinine 39.0 +- 2.3 mumol/L vs. 78.5 +- 10.0 mumol/L, p &lt; 0.05; mean injury score 31 +- 7% vs. 56 +- 5%, p &lt; 0.05).	Creatinine	130-140	protein C receptor	Homo sapiens	0-5
22380485-10	2012	Gender differences in cystatin C-based MELD were less pronounced than those in the creatinine-based model, because creatinine but not cystatin C was affected by gender.	Creatinine	115-125	cystatin C	Homo sapiens	22-32
23099840-9	2012	We detected a significant statistical correlation between serum creatinine and cystatin C (r = 0.81, p &lt; 0.0001), cystatin C and creatinine clearance estimated by stature (r = -0.84, p &lt; 0.0001) and between serum creatinine and creatinine clearance estimated by stature (r = -0.97, p &lt; 0.0001).	Creatinine	64-74	cystatin C	Homo sapiens	79-89
23099840-9	2012	We detected a significant statistical correlation between serum creatinine and cystatin C (r = 0.81, p &lt; 0.0001), cystatin C and creatinine clearance estimated by stature (r = -0.84, p &lt; 0.0001) and between serum creatinine and creatinine clearance estimated by stature (r = -0.97, p &lt; 0.0001).	Creatinine	132-142	cystatin C	Homo sapiens	117-127
23099840-9	2012	We detected a significant statistical correlation between serum creatinine and cystatin C (r = 0.81, p &lt; 0.0001), cystatin C and creatinine clearance estimated by stature (r = -0.84, p &lt; 0.0001) and between serum creatinine and creatinine clearance estimated by stature (r = -0.97, p &lt; 0.0001).	Creatinine	132-142	cystatin C	Homo sapiens	117-127
23099840-9	2012	We detected a significant statistical correlation between serum creatinine and cystatin C (r = 0.81, p &lt; 0.0001), cystatin C and creatinine clearance estimated by stature (r = -0.84, p &lt; 0.0001) and between serum creatinine and creatinine clearance estimated by stature (r = -0.97, p &lt; 0.0001).	Creatinine	132-142	cystatin C	Homo sapiens	117-127
22127401-3	2012	RESULTS: The serum level of cystatin C was positively correlated with age (P &lt; 0.001), duration of diabetes (P = 0.013), serum creatinine (P &lt; 0.001), uric acid (P &lt; 0.001), and adiponectin (p = 0.001), while it was inversely correlated with estimated glomerular filtration rate (P &lt; 0.001).	Creatinine	130-140	cystatin C	Homo sapiens	28-38
22278599-4	2012	RESULTS: Serum cystatin C was correlated with blood urea nitrogen (r = 0.537, p &lt; 0.001), serum creatinine (r = 0.480, p &lt; 0.001) and smoking (r = 0.284, p = 0.021).	Creatinine	99-109	cystatin C	Homo sapiens	15-25
22057374-0	2012	Cystatin C is a good predictor of hepatorenal syndrome and survival in patients with cirrhosis who have normal serum creatinine levels.	Creatinine	117-127	cystatin C	Homo sapiens	0-10
22057374-1	2012	BACKGROUND/AIMS: We evaluated the usefulness of cystatin C as a prognostic marker in patients with liver cirrhosis and normal serum creatinine.	Creatinine	132-142	cystatin C	Homo sapiens	48-58
22057374-11	2012	CONCLUSIONS: In patients with liver cirrhosis and normal creatinine levels, cystatin C is a useful marker for predicting hepatorenal syndrome and survival.	Creatinine	57-67	cystatin C	Homo sapiens	76-86
22499586-2	2012	We assessed creatinine-based GFR estimating equations in a cross-section of 751 adolescents and young adults (1054 measurements), using inulin clearance (measured GFR [mGFR]) as the reference method.	Creatinine	12-22	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	29-32
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	cystatin C	Homo sapiens	182-192
26921980-0	2016	Association of Peak Changes in Plasma Cystatin C and Creatinine With Death After Cardiac Operations.	Creatinine	53-63	cystatin C	Homo sapiens	38-48
26525196-5	2016	However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls (p &lt; 0.001).	Creatinine	38-48	chitinase 3 like 1	Homo sapiens	31-37
26981882-8	2016	The levels of oleic acid, linoleic acid, and creatinine were significantly increased in the plasma of both C3H-FB and G6PDx-FB mice.	Creatinine	45-55	glucose-6-phosphate dehydrogenase X-linked	Mus musculus	118-123
22565176-6	2012	We found strong correlations of cystatin C with creatinine (r = 0.9454), urea (r = 0.8999) and uric acid (r = 0.8325).	Creatinine	48-58	cystatin C	Homo sapiens	32-42
22565176-8	2012	Cystatin C has a strong association with MDRD (r = 0.8086) and CG (r = 0.7915) and a low one with creatinine clearance (r = 0.1044).	Creatinine	98-108	cystatin C	Homo sapiens	0-10
22432114-7	2012	Changes in serum cystatin C recapitulated the serum creatinine changes.	Creatinine	52-62	cystatin C	Homo sapiens	17-27
22207347-10	2012	In one case, the rise in cystatin C preceded creatinine by 1 day.	Creatinine	45-55	cystatin C	Homo sapiens	25-35
22207347-13	2012	By multiple linear regression analysis, the maximum rise of cystatin C was related to the maximum rise of creatinine, but independent of patient age, gender, steroid dose, and anthropometric data.	Creatinine	106-116	cystatin C	Homo sapiens	60-70
22388796-10	2012	CONCLUSION: CYP3A4*22 constitutes a risk factor for DGF and worse creatinine clearance in patients receiving CsA-based immunosuppressive therapy.	Creatinine	66-76	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	109-112
22435948-4	2012	Multivariate Cox proportional hazard regression model with a backward stepwise procedure was applied to select factors with significant effects on worsening of nephropathy stage and the doubling of serum creatinine.	Creatinine	204-214	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
22237752-4	2012	Increased epithelial syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy, and prolonged allograft survival.	Creatinine	88-98	syndecan 1	Mus musculus	21-31
22455670-13	2012	Comparisons of the concentrations of creatinine-corrected hydroxy-PAH to those reported in other studies indicate that exposure of public transport drivers to PAH could be similar.	Creatinine	37-47	phenylalanine hydroxylase	Homo sapiens	66-69
21622483-6	2011	The correlation between urinary arsenic concentration and NAG activity in urine was significant only in subjects who did not consume seafood within 3 days prior to urine sampling and whose urinary NAG activity was 7.44 U/g creatinine (75th percentile) or higher.	Creatinine	223-233	O-GlcNAcase	Homo sapiens	58-61
21622483-7	2011	The urinary arsenic concentration was a significant determinant of urinary NAG activity in subjects with NAG activity higher than 7.44 U/g creatinine and especially in those who had not consumed seafood recently.	Creatinine	139-149	O-GlcNAcase	Homo sapiens	75-78
21949094-6	2011	In contrast, administration of recombinant IL-33 (rIL-33) exacerbated cisplatin-induced AKI, measured by an increase in CD4 T cell infiltration, serum creatinine, ATN, and apoptosis; this did not occur in CD4-deficient mice, suggesting that CD4 T cells mediate the injurious effect of IL-33.	Creatinine	151-161	interleukin 33	Homo sapiens	43-48
21949094-6	2011	In contrast, administration of recombinant IL-33 (rIL-33) exacerbated cisplatin-induced AKI, measured by an increase in CD4 T cell infiltration, serum creatinine, ATN, and apoptosis; this did not occur in CD4-deficient mice, suggesting that CD4 T cells mediate the injurious effect of IL-33.	Creatinine	151-161	interleukin 33	Rattus norvegicus	50-56
27051593-7	2016	The CD89xTG2 formula had a high ability to discriminate active from inactive IgAN/HSPN in both situations: CD89xTG2/proteinuria ratio (AUC: 0.84, P &lt; 0.001, sensitivity: 76%, specificity: 74%) and CD89xTG2/urinary creatinine ratio (AUC: 0.82, P &lt; 0.001, sensitivity: 75%, specificity: 74%).	Creatinine	217-227	IGAN1	Homo sapiens	77-81
26925119-1	2016	INTRODUCTION: Current guidelines suggest using cystatin-C to confirm a reduced creatinine-based estimated glomerular filtration rate (eGFRcr) when the latter is thought to be inaccurate.	Creatinine	79-89	cystatin C	Homo sapiens	47-57
26628110-6	2016	Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation (eGFRcr-cys).	Creatinine	143-153	cystatin C	Homo sapiens	154-164
22253951-9	2011	CONCLUSION: Serum cystatin C showed a high correlation with measured GFR in young and older patients with CKD than creatinine.	Creatinine	115-125	cystatin C	Homo sapiens	18-28
22289997-10	2011	In the Sham group, only the level of NAG/Cr at 0-6 hours was significantly higher.	Creatinine	41-43	O-GlcNAcase	Rattus norvegicus	37-40
22289997-11	2011	The increase in NAG/Cr levels at 0-6 hours was significantly higher in the Trauma group than in the Sham group.	Creatinine	20-22	O-GlcNAcase	Rattus norvegicus	16-19
21623661-8	2011	TLR3 expression correlated positively with HCV viral load, interleukin-1beta, serum creatinine and inversely with creatinine clearance in patients with HCV-positive glomerulonephritis.	Creatinine	84-94	toll like receptor 3	Homo sapiens	0-4
21623661-8	2011	TLR3 expression correlated positively with HCV viral load, interleukin-1beta, serum creatinine and inversely with creatinine clearance in patients with HCV-positive glomerulonephritis.	Creatinine	114-124	toll like receptor 3	Homo sapiens	0-4
22055590-6	2011	RESULTS: Early HRS was identified by the raised cystatin C in 56.3% of patients having normal creatinine.	Creatinine	94-104	cystatin C	Homo sapiens	48-58
22055590-7	2011	Cystatin C correlated significantly with creatinine in HRS-2 (r=0.74; p&lt;0.001) and showed a significantly lower multiplication ratio (folds of rise) compared to creatinine in HRS-1 patients (p&lt;0.01).	Creatinine	41-51	cystatin C	Homo sapiens	0-10
21715185-8	2011	Galectin-3 positively correlated with urea and creatinine, and PVS galectin-3 showed a negative association with creatinine clearance as an accepted measure of kidney function.	Creatinine	47-57	galectin 3	Homo sapiens	0-10
21715185-8	2011	Galectin-3 positively correlated with urea and creatinine, and PVS galectin-3 showed a negative association with creatinine clearance as an accepted measure of kidney function.	Creatinine	113-123	galectin 3	Homo sapiens	67-77
21324976-11	2011	Moreover, CCL18 effluent concentrations correlated with decreased peritoneal function, which was evaluated as dialysate to plasma ratio of creatinine (r = 0.724, P &lt; 0.0001), and were significantly higher in patients with UFF (P = 0.0025) and in those who later developed sclerosing peritonitis (P = 0.024).	Creatinine	139-149	C-C motif chemokine ligand 18	Homo sapiens	10-15
22042347-9	2011	But, when the serum creatinine levels were considered in the same groups, a marginally significant difference among them (p = 0.070) was observed, which suggested that the difference in cystatin C levels between the groups was caused by their respective glomerular filtration rate.	Creatinine	20-30	cystatin C	Homo sapiens	186-196
21454717-1	2011	Estimation of the GFR (eGFR) using creatinine- or cystatin C-based equations is imperfect, especially when the true GFR is normal or near-normal.	Creatinine	35-45	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	18-21
21454717-1	2011	Estimation of the GFR (eGFR) using creatinine- or cystatin C-based equations is imperfect, especially when the true GFR is normal or near-normal.	Creatinine	35-45	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	24-27
21454717-7	2011	These results suggest that eGFR, calculated using standard creatinine- or cystatin C-based equations, partially depends on factors other than the true GFR.	Creatinine	59-69	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	28-31
23154672-10	2012	In multiple regression analysis VAP-1 was predicted 80% by serum creatinine (beta value 0.33, p=0.01), and CD146 (beta value 43, p=0.0005).	Creatinine	65-75	amine oxidase copper containing 3	Homo sapiens	32-37
23024773-5	2012	In an independent cohort of 74 biopsies of glomerular diseases renal RNA levels of versican isoforms V0 and V1, but not V2 and V3 correlated significantly with creatinine after a mean follow up time of 53 months.	Creatinine	160-170	versican	Homo sapiens	83-91
23024773-6	2012	Versican isoforms V0 and V1 together with serum creatinine at time of biopsy and the degree of glomerulosclerosis predicted 20% and 24% of the variability of creatinine at follow up, which was significantly more than serum creatinine and histological parameters alone (16%).	Creatinine	158-168	versican	Homo sapiens	0-8
23024773-6	2012	Versican isoforms V0 and V1 together with serum creatinine at time of biopsy and the degree of glomerulosclerosis predicted 20% and 24% of the variability of creatinine at follow up, which was significantly more than serum creatinine and histological parameters alone (16%).	Creatinine	158-168	versican	Homo sapiens	0-8
22815718-13	2012	Significant predictors of urine MTB/RIF positivity were CD4&lt;50 cells/ml (p = 0.001), elevated protein-to-creatinine ratio (p&lt;0.001) and LAM ELISA positivity (p&lt;0.001).	Creatinine	108-118	ras homolog family member F, filopodia associated	Homo sapiens	36-39
22016382-8	2012	Urinary creatinine was also quantified as a measure of hydration and was significantly reduced in males treated with E(2).	Creatinine	8-18	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	117-121
21880835-11	2011	COX-2(-/-) mice had elevated plasma urea and creatinine and accumulation of small subcapsular glomeruli.	Creatinine	45-55	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
26603313-7	2016	RESULTS: Anti-HMGB1 administration prevented the increases in serum creatinine and 24h albuminuria and the decrease in creatinine clearance associated with CsA treatment.	Creatinine	68-78	high mobility group box 1	Mus musculus	14-19
26603313-7	2016	RESULTS: Anti-HMGB1 administration prevented the increases in serum creatinine and 24h albuminuria and the decrease in creatinine clearance associated with CsA treatment.	Creatinine	119-129	high mobility group box 1	Mus musculus	14-19
26753722-6	2016	In acute rejection, PD-1 and FOXP3 mRNA were significantly correlated with serum creatinine and Banff histological grade.	Creatinine	81-91	programmed cell death 1	Homo sapiens	20-24
26753722-6	2016	In acute rejection, PD-1 and FOXP3 mRNA were significantly correlated with serum creatinine and Banff histological grade.	Creatinine	81-91	forkhead box P3	Homo sapiens	29-34
26362696-11	2016	The average of the BTP-B2M equation and the CKD-EPI creatinine-cystatin C equation was not more accurate than the CKD-EPI creatinine-cystatin C equation.	Creatinine	52-62	cystatin C	Homo sapiens	63-73
27400282-10	2016	CONCLUSION: Cystatin C-creatinine-based GFR equations outperform creatinine-based formula in obese CKD patients especially those with BMI &gt;=35 and in obese women.	Creatinine	23-33	cystatin C	Homo sapiens	12-22
26594819-2	2016	Guidelines recommend measured GFR (mGFR), using either an endogenous filtration marker or creatinine clearance, rather than estimated GFR (eGFR), but measurement methods are difficult, time consuming and costly.	Creatinine	90-100	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	35-39
26594819-3	2016	We investigated whether GFR estimated from serum creatinine (eGFRcr) with or without sequential cystatin C is sufficiently accurate to identify donor candidates with high probability that mGFR is above or below thresholds for clinical decision making.	Creatinine	49-59	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	24-27
26247791-9	2015	For CD31(+)CD45(-)CD146(-) counts, representing large platelets, an inverse relationship with strut coverage was identified by a multivariable regression model adjusting for age, sex, diabetes mellitus, NYHA and CCS class, CRP, serum triglycerides, glucose and creatinine (beta=-9.42, p=0.006).	Creatinine	261-271	platelet and endothelial cell adhesion molecule 1	Homo sapiens	4-8
21944667-5	2011	PREDICTORS: Quintile of measured GFR (mGFR) by iothalamate clearance, serum creatinine, serum creatinine-based eGFR, cystatin C, and BTP values.	Creatinine	94-104	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	33-36
21944667-5	2011	PREDICTORS: Quintile of measured GFR (mGFR) by iothalamate clearance, serum creatinine, serum creatinine-based eGFR, cystatin C, and BTP values.	Creatinine	94-104	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	38-42
21827355-9	2011	In univariate analyses plasma YKL-40 was significantly associated with ischemic myocardium score, age, hypertension, peripheral vascular disease and serum creatinine levels.	Creatinine	155-165	chitinase 3 like 1	Homo sapiens	30-36
21646913-1	2011	BACKGROUND: Cystatin C has been proposed as an alternative marker of kidney function among HIV-infected persons in whom serum creatinine is affected by extrarenal factors.	Creatinine	126-136	cystatin C	Homo sapiens	12-22
21838881-8	2011	When adjusted for age, HbA1c and U-albumin creatinine ratio in a multivariate logistic regression analysis, plasma OPG remained strongly associated with carotid arterial disease (adjusted OR: 2.12; 95% CI: 1.22-3.67; p = 0.008), but not with peripheral arterial disease or myocardial ischemia.	Creatinine	43-53	TNF receptor superfamily member 11b	Homo sapiens	115-118
21482744-14	2011	Net reclassification improvement for death was 13.3% (P &lt; .001) and for end-stage renal disease was 6.4% (P &lt; .001) after adding estimated GFR cystatin C in fully adjusted models with estimated GFR creatinine and ACR.	Creatinine	204-214	cystatin C	Homo sapiens	149-159
21352605-7	2011	CRT, taurine transporter (TauT/SLC6A6) and organic cation transporter (OCT3/SLC22A3) expressed at the BCSFB are involved in guanidinoacetic acid or creatinine efflux transport from CSF.	Creatinine	148-158	solute carrier family 6 member 6	Homo sapiens	26-30
21352605-7	2011	CRT, taurine transporter (TauT/SLC6A6) and organic cation transporter (OCT3/SLC22A3) expressed at the BCSFB are involved in guanidinoacetic acid or creatinine efflux transport from CSF.	Creatinine	148-158	solute carrier family 6 member 6	Homo sapiens	31-37
21310322-9	2011	After multivariable adjustment, both BTP (hazard ratio: 1.41, 95% confidence interval: 1.06 to 1.88; p = 0.018) and cystatin C (hazard ratio: 1.50, 95% confidence interval: 1.13 to 2.01; p = 0.006) were significant predictors of death/HF hospitalization, whereas serum creatinine, estimated glomerular filtration rate, and blood urea nitrogen were no longer significant.	Creatinine	269-279	cystatin C	Homo sapiens	116-126
26392310-7	2015	The urinary phosphorus/creatinine ratio was increased in Pmca1(EKO) mice (P &lt; 0.004).	Creatinine	23-33	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	57-62
21577179-5	2011	RESULTS: At 5 hr, serum creatinine and blood urea nitrogen levels were markedly reduced in IFNAR-/- mice as compared with WT.	Creatinine	24-34	interferon (alpha and beta) receptor 1	Mus musculus	91-96
21454251-6	2011	Serum creatinine level in MMP-9-null mice 24 h after injury [1.4 (SD 0.8) mg/dl] was not significantly different from FVB/NJ mice [1.5 (SD 0.6) mg/dl].	Creatinine	6-16	matrix metallopeptidase 9	Mus musculus	26-31
21699724-4	2011	RESULTS: After controlling for age and BMI, Ang-2 levels were associated with levels of sTie-2, diastolic blood pressure, plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR), creatinine, glomerular filtration rate (GFR), and gamma-glutamyl transferase (GGT) (all p &lt; 0.02).	Creatinine	200-210	angiopoietin 2	Homo sapiens	44-49
21438718-10	2011	Among 41 confirmed nonsmokers, the geometric mean (95% CI) of 4-ABP concentration was 1.64 pg/mg creatinine (1.30-2.07).	Creatinine	97-107	amine oxidase copper containing 1	Homo sapiens	64-67
21438718-11	2011	Conversely, in 89 smokers, the geometric mean of 4-ABP concentration was significantly greater, at 8.69 pg/mg creatinine (7.43-10.16), p &lt; 0.001.	Creatinine	110-120	amine oxidase copper containing 1	Homo sapiens	51-54
26351984-9	2015	Urinary hK1-specific amidase activity was expressed as microM/(min   mg creatinine) to correct for differences in urine flow rates.	Creatinine	72-82	keratin 1	Homo sapiens	8-11
26509856-0	2015	COMBINING CREATININE-BASED eGFR WITH CYSTATIN C-BASED EGFR TO BETTER ASSESS RENAL FUNCTION IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE 3A: IMPLICATIONS FOR DRUG SELECTION AND DOSAGE IN TYPE 2 DIABETES.	Creatinine	10-20	cystatin C	Homo sapiens	37-47
26648945-6	2015	Creatinine eGFR resulted in a less advanced eGFR category in the majority of patients with a cystatin C eGFR &lt;60 ml/min/1.73 m(2).	Creatinine	0-10	cystatin C	Homo sapiens	93-103
21303425-6	2011	Glomerular expression of CXCR3 significantly correlated with proteinuria (r = -0.532; P = 0.019), whereas tubulointerstitial CXCR3 significantly correlated with serum creatinine (r = -0.447; P = 0.029).	Creatinine	167-177	C-X-C motif chemokine receptor 3	Homo sapiens	125-130
21518555-11	2011	MICA antibodies positive group had higher serum creatinine level than the control in postoperative one week ((135.4 +- 21.4) micromol/L vs. (108.6 +- 31.6) micromol/L, P = 0.036), but no significant difference in postoperative four weeks ((89.0 +- 17.1) micromol/L vs. (77.1 +- 15.9) micromol/L, P = 0.089).	Creatinine	48-58	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
21661351-7	2011	In DM2 group we found a significant correlation between BHIadj and age (p = 0.0004), fasting glycemia (p = 0.04), and albuminuria (p = 0.04) (creatinine clearance in multivariate analysis (p = 0.007)).	Creatinine	142-152	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	3-6
21242461-6	2011	Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli.	Creatinine	37-47	renin	Rattus norvegicus	76-79
21242461-6	2011	Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli.	Creatinine	129-139	renin	Rattus norvegicus	76-79
26240296-2	2015	Prior studies have demonstrated that comorbidities such as solid-organ transplant strongly influence the relationship between measured GFR, creatinine, and cystatin C.	Creatinine	140-150	cystatin C	Homo sapiens	156-166
26832708-7	2015	And compared to the control group, activity of serum alanine aminotransferase (ALT) and aspartic acid transaminase (AST) decreased significantly in group of paraquat poisoning with triple application of SB, the level of serum urea nitrogen (BUN) and creatinine (Cr) significantly decreased, the difference is statistically significant (P&lt;0.01).	Creatinine	250-260	glutamic--pyruvic transaminase	Homo sapiens	53-77
26832708-7	2015	And compared to the control group, activity of serum alanine aminotransferase (ALT) and aspartic acid transaminase (AST) decreased significantly in group of paraquat poisoning with triple application of SB, the level of serum urea nitrogen (BUN) and creatinine (Cr) significantly decreased, the difference is statistically significant (P&lt;0.01).	Creatinine	262-264	glutamic--pyruvic transaminase	Homo sapiens	53-77
25965624-11	2015	In multivariable Cox-regression analysis creatinine remained the only significant independent predictor of kidney biomarkers of time to death during the first year.	Creatinine	41-51	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
21314784-13	2011	In multivariate modeling, after adjusting for age, sex, heart rate, white blood cell count, and creatinine, an elevated BNP was associated with increased odds of having the composite outcome.	Creatinine	96-106	natriuretic peptide B	Homo sapiens	120-123
21307744-9	2011	The CIn correlated (p&lt;0.0005) with CCr in all patients, whereas the CIn was lower than CCr due to the tubular excretion of creatinine.	Creatinine	126-136	pyridoxal phosphatase	Homo sapiens	71-74
21226861-14	2011	Cystatin C has, in this study population, a stronger correlation to iohexol clearance than creatinine.	Creatinine	91-101	cystatin C	Homo sapiens	0-10
21272132-9	2011	CONCLUSION: Approximately 40% of marathon runners experience a transient rise in serum creatinine that meets criteria of AKI with a parallel elevation of cystatin C, and supportive elevations of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in the urine.	Creatinine	87-97	cystatin C	Homo sapiens	154-164
21088975-12	2011	CysC levels were correlated with CMRFs factors independently of renal function, and affected by skeletal muscle mass in severely obese children, although they are less influenced by this than is creatinine.	Creatinine	195-205	cystatin C	Homo sapiens	0-4
20947817-7	2011	In multivariable regression analyses that adjusted for age, sex, smoking, hypertension, history of coronary heart disease/stroke, systolic blood pressure, and serum creatinine, NT pro-BNP levels remained significantly higher in patients with PCA than in patients with PAD and controls (P&lt;0.001).	Creatinine	165-175	natriuretic peptide B	Homo sapiens	184-187
21619490-9	2011	Cystatin C levels correlated positively with creatinine, and negatively with eGFR(CG) and eGFR(MDRD).	Creatinine	45-55	cystatin C	Homo sapiens	0-10
25707515-6	2015	There was a significant relationship between creatinine and cystatin C levels.	Creatinine	45-55	cystatin C	Homo sapiens	60-70
25943388-8	2015	RESULTS: In the mixed-effects model BNP was significantly influenced by time, baseline patient age, gender, LV fractional ejection fraction and creatinine.	Creatinine	144-154	natriuretic peptide B	Homo sapiens	36-39
25902541-8	2015	Switching Tgfb1 expression from low to high in the tubules of the hypomorphs increased their albumin excretion more than 10-fold but creatinine clearance remained high.	Creatinine	133-143	transforming growth factor, beta 1	Mus musculus	10-15
25902541-9	2015	Switching Tgfb1 expression from low to high in the podocytes markedly decreased creatinine clearance, but minimally increased albumin excretion.	Creatinine	80-90	transforming growth factor, beta 1	Mus musculus	10-15
24867223-1	2015	BACKGROUND: The European Society of Urogenital Radiology (ESUR) propose measurements of serum creatinine levels in patients undergoing contrast-enhanced studies with a high probability of impaired renal function and therefore with a higher risk of CIN and NSF.	Creatinine	94-104	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	256-259
26039951-7	2015	The mean aspartate aminotransferase and alanine aminotransferase serum levels showed a reduction in proportion to the increase in creatinine levels (p=0.001 and p=0.05, respectively) and the decrease in glomerular filtration rate (p=0.007 and p=0.028, respectively).	Creatinine	130-140	glutamic--pyruvic transaminase	Homo sapiens	40-64
21163122-8	2010	There was significant dominance of the male (P &lt; 0.05), more marked hypertension (P &lt; 0.01), proteinuria (P &lt; 0.01) and increased serum creatinine during renal biopsy (P &lt; 0.01) in the IgAN-ESRD group.	Creatinine	145-155	IGAN1	Homo sapiens	197-201
21461013-8	2011	RESULTS: Compared to infants without vesicoureteral reflux (VUR) (n=68), infants with VUR (n=11; two with Grade I, three with Grade II, five with Grade III, two with Grade IV) showed a significantly lower (P=.006) maximum urine osmolality and a significantly higher microalbumin/creatinine ratio (P&lt;.001) and NAG/creatinine ratio (P=.003).	Creatinine	279-289	VUR	Homo sapiens	86-89
21461013-8	2011	RESULTS: Compared to infants without vesicoureteral reflux (VUR) (n=68), infants with VUR (n=11; two with Grade I, three with Grade II, five with Grade III, two with Grade IV) showed a significantly lower (P=.006) maximum urine osmolality and a significantly higher microalbumin/creatinine ratio (P&lt;.001) and NAG/creatinine ratio (P=.003).	Creatinine	316-326	VUR	Homo sapiens	86-89
26039951-9	2015	CONCLUSIONS: The aspartate aminotransferase and alanine aminotransferase serum levels of patients with predialysis chronic kidney disease decreased in proportion to the progression of the disease; they were negatively correlated with creatinine levels and directly correlated with glomerular filtration rate.	Creatinine	234-244	glutamic--pyruvic transaminase	Homo sapiens	48-72
25762421-9	2015	The area under the receiver operating characteristic (ROC) curve for predicting severe AKI was 0.87 [95% confidence interval (CI), 0.69-0.97] for plasma MIF, 0.61 (95% CI, 0.40-0.79) for serum creatinine (sCr), and 0.90 (95% CI, 0.72-0.98) for delta serum creatinine (DeltasCr).	Creatinine	193-203	macrophage migration inhibitory factor	Homo sapiens	153-156
25762421-9	2015	The area under the receiver operating characteristic (ROC) curve for predicting severe AKI was 0.87 [95% confidence interval (CI), 0.69-0.97] for plasma MIF, 0.61 (95% CI, 0.40-0.79) for serum creatinine (sCr), and 0.90 (95% CI, 0.72-0.98) for delta serum creatinine (DeltasCr).	Creatinine	256-266	macrophage migration inhibitory factor	Homo sapiens	153-156
25656833-5	2015	Routine serum and urinary biochemical variables, urinary NAG to Creatinine (U(NAG/Cr)), U(NGAL/Cr), U(KIM-1/Cr), and U(L-FABP/Cr) ratios were determined.	Creatinine	64-74	O-GlcNAcase	Homo sapiens	57-60
26045825-9	2015	Furthermore, serum OIF had negative correlation with estimated glomerular filtration rate (eGFR) and positive correlation with blood urea nitrogen(BUN) and creatinine.	Creatinine	156-166	osteoglycin	Homo sapiens	19-22
25448538-7	2015	There was poor correlation between plasma creatinine and cystatin C levels (r=.501; P=.001), which disappeared upon reaching any degree of renal impairment on the RIFLE scale.	Creatinine	42-52	cystatin C	Homo sapiens	57-67
26168668-10	2015	0)%, albumin (36 +- 4 vs 40 +- 4) g/L and creatinine (72 +- 20 vs 81 +- 22) micromol/L were much lower in patients with BPPV versus controls (P &lt; 0.	Creatinine	42-52	benign paroxysmal positional vertigo	Homo sapiens	120-124
20607577-2	2010	The levels of Cr and CysC (Cr/CysC) were respectively as follows: 12.16 mg/dl/1.26 mg/l, 17.92 mg/dl/0.95 mg/l and 18.94 mg/dl/0.55 mg/l.	Creatinine	27-29	cystatin C	Homo sapiens	21-25
21184545-6	2010	However, by multivariable Cox regression, only increases in creatinine after 48 h (HRR 1.608, 95% CI 1.002-2.581) and after 30 d (HRR 2.685, 95% CI 1.598-4.511) turned out to be significant and independent predictors of mortality.	Creatinine	60-70	nuclear receptor subfamily 1 group H member 4	Homo sapiens	83-88
20515558-5	2010	Multiple regression analysis found that serum hs-CRP, creatinine and triglyceride levels, and the homeostasis model assessment of insulin resistance (HOMA-IR) and body mass index were significantly and independently associated with serum PEDF levels.	Creatinine	54-64	serpin family F member 1	Homo sapiens	238-242
20515562-3	2010	By comparing the correlation of CysC and serum creatinine (SCr) with GFR, it was concluded that CysC may be a better indicator of GFR than SCr in diabetic patients, in both the early hypertransfusion stage and in the late renal dysfunction stage.	Creatinine	47-57	cystatin C	Homo sapiens	96-100
20032962-9	2010	Renal organic anion transporter 1 mRNA expression was higher in male than in female mice, reflecting the gender difference in creatinine secretion.	Creatinine	126-136	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	0-33
20470278-7	2010	In the healthy volunteers visfatin correlated significantly with ICAM, creatinine and IL-6.	Creatinine	71-81	nicotinamide phosphoribosyltransferase	Homo sapiens	26-34
18793808-6	2010	RESULTS: The overall incidence of cystatin C-based CIN among all study subjects was 10.2% (5.0% in N-acetylcysteine group and 15.1% in control group, p&lt;0.05) and that of serum creatinine-based CIN was 6% (3.8% in N-acetylcysteine group and 8.1% in control group, p=NS).	Creatinine	179-189	cystatin C	Homo sapiens	34-44
20113216-5	2010	Age, body mass index, triglycerides and creatinine, estimated glomerular filtration rate and left ventricular mass index were independently associated with cystatin C levels.	Creatinine	40-50	cystatin C	Homo sapiens	156-166
26491688-1	2015	The aim of this study was to assess the significance of the neutrophil gelatinase-associated lipocalin/serum creatinine ratio (NGAL/sCr ratio) in patients with renal dysfunction.	Creatinine	109-119	matrix metallopeptidase 2	Homo sapiens	60-81
25050869-9	2015	PEDF values showed a positive correlation with microalbumin/creatinine, hb A1c, FBS, systolic and diastolic BP levels.	Creatinine	60-70	serpin family F member 1	Homo sapiens	0-4
26265923-5	2015	Administration of Cyp resulted in a significant increase in serum marker enzymes, for example, aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), and increases the level of urea nitrogen and creatinine.	Creatinine	239-249	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	18-21
19585181-7	2009	When Cr was lower than 1.10 mg/dl, CysC rose more sharply than Cr.	Creatinine	5-7	cystatin C	Homo sapiens	35-39
19585181-8	2009	CysC divided by Cr (CysC/Cr) was higher in females (1.35 +/- 0.33 vs. 1.16 +/- 0.30; p &lt; 0.001), in patients with elevated CRP (1.33 +/- 0.40 vs. 1.21 +/- 0.29; p &lt; 0.001) and in patients prescribed with prednisolone (1.42 +/- 0.33 vs. 1.20 +/- 0.30; p &lt; 0.001).	Creatinine	16-18	cystatin C	Homo sapiens	0-4
19585181-8	2009	CysC divided by Cr (CysC/Cr) was higher in females (1.35 +/- 0.33 vs. 1.16 +/- 0.30; p &lt; 0.001), in patients with elevated CRP (1.33 +/- 0.40 vs. 1.21 +/- 0.29; p &lt; 0.001) and in patients prescribed with prednisolone (1.42 +/- 0.33 vs. 1.20 +/- 0.30; p &lt; 0.001).	Creatinine	16-18	cystatin C	Homo sapiens	20-24
19585181-8	2009	CysC divided by Cr (CysC/Cr) was higher in females (1.35 +/- 0.33 vs. 1.16 +/- 0.30; p &lt; 0.001), in patients with elevated CRP (1.33 +/- 0.40 vs. 1.21 +/- 0.29; p &lt; 0.001) and in patients prescribed with prednisolone (1.42 +/- 0.33 vs. 1.20 +/- 0.30; p &lt; 0.001).	Creatinine	25-27	cystatin C	Homo sapiens	0-4
25932809-1	2015	BACKGROUND: Cystatin C is an endogenous marker of kidney function that overcomes the limitations of serum creatinine.	Creatinine	106-116	cystatin C	Homo sapiens	12-22
19954723-8	2009	The magnitude of 4-year decline of above four renal parameters was significantly higher in subjects carrying the AT1R AA genotype than C-allele carriers (p = 0.014, 0.033, 0.008 and 0.014 for creatinine, CG CrCl, MDRD and abMDRD GFR, respectively).	Creatinine	192-202	angiotensin II receptor type 1	Homo sapiens	113-117
20120531-8	2009	Significantly negative correlation between BNP level and creatinine clearance (p = 0.009), and significantly positive correlation between BNP level and left ventricular mass index (LVMI) were established.	Creatinine	57-67	natriuretic peptide B	Homo sapiens	43-46
19756503-10	2009	After multivariable adjustment, the progression to "ESRD" was associated with higher baseline creatinine, odds ratio (OR) 1.19 per every increase in creatinine of 0.1 mg/dl (95% CI, 1.11-1.29) P &lt; 0.001; and less frequent use of CRRT, OR 0.18 (95% CI, 0.11-0.29) P &lt; 0.001.	Creatinine	149-159	olfactory receptor family 7 subfamily E member 87 pseudogene	Homo sapiens	106-126
19729502-7	2009	Cystatin C exhibited significantly superior diagnostic accuracy for detecting GFR &lt;80 mL/min/1.73 m(2) compared with serum creatinine (P = 0.013) and Ccr (P = 0.025); for detecting GFR &lt;60 mL/min/1.73 m(2), cystatin C had similar diagnostic accuracy to Ccr (P = 0.812) but was superior to creatinine (P = 0.033).	Creatinine	295-305	cystatin C	Homo sapiens	0-10
19713275-6	2009	Importantly, cystatin C appears to be a useful marker for identifying individuals at a higher risk for cardiovascular events among patients belonging to a relatively low-risk category as assessed by both creatinine and estimated glomerular filtration rate values.	Creatinine	204-214	cystatin C	Homo sapiens	13-23
19812054-7	2009	Age, gender, ethnicity, body mass index, blood urea nitrogen, and creatinine affected BNP levels independently of HF.	Creatinine	66-76	natriuretic peptide B	Homo sapiens	86-89
25737772-8	2015	The elevation of serum soluble IL-2R was evident in acute rejection episodes and found before elevation of serum creatinine.	Creatinine	113-123	interleukin 2 receptor subunit alpha	Homo sapiens	31-36
25465906-9	2015	pNGAL, MR-ProADM, and cystatin C had the best odds ratio and area under the receiver-operating characteristic curve (AUC-ROC: 0.83 [0.75-0.9], 0.82 [0.71-0.91], and 0.83 [0.74-0.90]), but not different from serum creatinine (Screat, 0.80 [0.70-0.88]).	Creatinine	213-223	cystatin C	Homo sapiens	22-32
19544228-5	2009	The mean cystatin C increase was twice as low as compared to creatinine (21% and 41%, respectively), suggesting that cystatin C is indeed less biased by muscle damage.	Creatinine	61-71	cystatin C	Homo sapiens	117-127
19506046-2	2009	Measurement of kidney function using creatinine-based estimates is often inaccurate, while cystatin C may overcome the biases that effect creatinine.	Creatinine	138-148	cystatin C	Homo sapiens	91-101
19339088-0	2009	Revised equations for estimated GFR from serum creatinine in Japan.	Creatinine	47-57	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	32-35
19339088-1	2009	BACKGROUND: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities.	Creatinine	88-98	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	54-57
19339088-2	2009	Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories.	Creatinine	151-161	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	24-27
19119287-7	2009	Diabetes was associated with 8.5% higher levels of cystatin C and 3.9% lower levels of creatinine.	Creatinine	87-97	cystatin C	Homo sapiens	51-67
25362243-7	2015	The DREAM-Phil Bowen ALS Prediction Prize4Life challenge also identified several potential nonstandard predictors of disease progression including uric acid, creatinine and surprisingly, blood pressure, shedding light on ALS pathobiology.	Creatinine	158-168	potassium voltage-gated channel interacting protein 3	Homo sapiens	4-9
18957531-8	2009	Significant but weak intercorrelations of YKL-40 were found with age, diastolic blood pressure, A1C, and serum creatinine.	Creatinine	111-121	chitinase 3 like 1	Homo sapiens	42-48
19169006-3	2009	METHODS: We examined data from 304 patients with IgAN whose serum creatinine value at renal biopsy was &lt;2.0 mg/dl and who had been followed up for &gt;12 months.	Creatinine	66-76	IGAN1	Homo sapiens	49-53
18677713-8	2009	RESULTS: Multiple regression analyses revealed that waist circumference, triglycerides, creatinine, and TNF-alpha were independently associated with PEDF.	Creatinine	88-98	serpin family F member 1	Homo sapiens	149-153
19995705-10	2009	However, Cyst C level positively correlated with serum creatinine concentration (R=0.535; p=0.005) in patients who responded to chemotherapy and with patient"s age (R=0.456; p=0.018) in whole group.	Creatinine	55-65	cystatin C	Homo sapiens	9-15
18931022-10	2009	DPP4-deficient rats showed increased serum creatinine in accordance with decreased creatinine clearance as compared with wild-type rats after STZ treatment.	Creatinine	43-53	dipeptidylpeptidase 4	Rattus norvegicus	0-4
18931022-10	2009	DPP4-deficient rats showed increased serum creatinine in accordance with decreased creatinine clearance as compared with wild-type rats after STZ treatment.	Creatinine	83-93	dipeptidylpeptidase 4	Rattus norvegicus	0-4
26299173-0	2015	Serum cystatin C levels in preterm newborns in our setting: Correlation with serum creatinine and preterm pathologies.	Creatinine	83-93	cystatin C	Homo sapiens	6-16
25271041-4	2014	RESULTS: Mortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.	Creatinine	58-68	O-GlcNAcase	Homo sapiens	118-121
25465599-4	2014	RESULTS: Urinary NAG levels [Units/g creatinine; median (range)] were significantly increased in microalbuminuria group [17.0 (5.9 - 23.3)] compared to normoalbuminuria group [4.4 (1.5 - 9.2)] (P&lt;0.001).	Creatinine	37-47	O-GlcNAcase	Homo sapiens	17-20
25052363-11	2014	A positive correlation was found between urinary HMGB1/creatinine ratio and CD4(+) T cells/creatinine ratio (P = 0 028) and effector memory T cells/creatinine ratio (P = 0 039) in urine.	Creatinine	55-65	high mobility group box 1	Homo sapiens	49-54
25052363-11	2014	A positive correlation was found between urinary HMGB1/creatinine ratio and CD4(+) T cells/creatinine ratio (P = 0 028) and effector memory T cells/creatinine ratio (P = 0 039) in urine.	Creatinine	91-101	high mobility group box 1	Homo sapiens	49-54
25052363-11	2014	A positive correlation was found between urinary HMGB1/creatinine ratio and CD4(+) T cells/creatinine ratio (P = 0 028) and effector memory T cells/creatinine ratio (P = 0 039) in urine.	Creatinine	91-101	high mobility group box 1	Homo sapiens	49-54
25184282-8	2014	Spearman"s correlation analysis showed that serum CysC was closely related with age, sex, diabetes duration, hypertension, glomerular infiltration rate, and serum creatinine (Cr) level.	Creatinine	163-173	cystatin C	Homo sapiens	50-54
25184282-8	2014	Spearman"s correlation analysis showed that serum CysC was closely related with age, sex, diabetes duration, hypertension, glomerular infiltration rate, and serum creatinine (Cr) level.	Creatinine	175-177	cystatin C	Homo sapiens	50-54
25657756-9	2014	CONCLUSION: We suggest that serum Cr/CysC ratio seems to be a useful diagnostic tool for detection of postrenal AKI cases, especially for the cases without definite hydronephrosis.	Creatinine	34-36	cystatin C	Homo sapiens	37-41
25212579-6	2014	Lp(a) was inversely related to fasting glucose, insulin, and C-peptide, HOMA-index, and creatinine clearance and directly related to LDL-cholesterol.	Creatinine	88-98	lipoprotein(a)	Homo sapiens	0-5
19194560-3	2009	A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis.	Creatinine	174-184	angiotensin II receptor type 2	Homo sapiens	23-27
19194560-3	2009	A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis.	Creatinine	174-184	IGAN1	Homo sapiens	111-115
19554056-6	2009	Cystatin C was positively correlated with creatinine serum levels, estimated glomerular filtration rate, PTH levels and negatively with anti-oxidized LDL antibodies.	Creatinine	42-52	cystatin C	Homo sapiens	0-10
25212579-7	2014	Multiple regression analysis adjusted for age, sex, body mass index, blood pressure, smoking habit, alcohol intake, renal function, lipid profile, history of cardiovascular events, and drug use showed that HOMA-index and creatinine clearance were inversely and independently associated to Lp(a) levels.	Creatinine	221-231	lipoprotein(a)	Homo sapiens	289-294
25279852-5	2014	METHODS: This study enrolled 621 patients with stages 3-5 CKD to assess the association of circulating Ang-2 with commencing dialysis, doubling creatinine and rapid decline in renal function (the slope of estimated glomerular filtration rate (eGFR) greater than 5 ml/min per 1.73 m2/y) over follow-up of more than 3 years.	Creatinine	144-154	angiopoietin 2	Homo sapiens	103-108
24953204-7	2014	Alanine aminotransferase showed independent direct associations with body mass index, glycaemia, cholesterol, and triglycerides (p&lt;0.001), and inverse associations with high-density lipoprotein cholesterol (p&lt;0.001) and creatinine (p&lt;0.01).	Creatinine	226-236	glutamic--pyruvic transaminase	Homo sapiens	0-24
19238908-9	2009	In the multivariate Cox hazard analysis of the clinicopathologic factors, serum creatinine was selected as the most significant risk factor for death and/or end-stage renal failure (p=0.036).	Creatinine	80-90	cytochrome c oxidase subunit 8A	Homo sapiens	20-23
24958499-5	2014	A urinary protein, adipsin, was found significantly increased, and the adipsin creatinine ratio was closely correlated with the urinary 24-hour protein in patients with preeclampsia.	Creatinine	79-89	complement factor D	Homo sapiens	71-78
18800229-6	2009	The urine MIF/creatinine (Cr) ratio was significantly higher in pyelonephritis patients than in those with acute cystitis and the control group (P &lt; 0.001).	Creatinine	14-24	macrophage migration inhibitory factor	Homo sapiens	10-13
18788400-2	2008	Recently, novel technique to evaluate glomerular filtration has been developed, including cystatin C, which reflects the changes in GFR at the earlier stage than serum creatinine.	Creatinine	168-178	cystatin C	Homo sapiens	90-100
19115622-7	2008	But the polymorphism of Rsa I / Pst I site of CYP2E1 5"-franking region was not correlated with the concentration of urine formic acid (chi2 = 4.285, P=0.117), and the urinary formic acid means of subjects with C1/C1, C1/C2, C2/C2 genotype were (11.14 +/- 7.91), (12.13 +/- 8.16) and (16.51 -/+ 3.78) mg/g creatinine, respectively.	Creatinine	306-316	sulfotransferase family 1A member 1	Homo sapiens	32-35
18371537-10	2008	ACE/ACE2 ratio correlated positively with values for mean blood pressure, fasting blood glucose, serum creatinine, proteinuria, and hemoglobin A(1c) and inversely with estimated glomerular filtration rate (P < 0.001).	Creatinine	103-113	angiotensin converting enzyme 2	Homo sapiens	4-8
25380936-10	2014	In multivariate analysis, only creatinine was found to be a predictor of YKL-40 (beta = 0.59; P = .02), explaining 56% of the variation in YKL-40 levels in heart allograft recipients.	Creatinine	31-41	chitinase 3 like 1	Homo sapiens	73-79
18227177-12	2008	In the Cox model, patients taking &gt;or=4 g vancomycin/day, a total body weight of &gt;or=101.4 kg, estimated creatinine clearance of &lt;/=86.6 ml/min, and intensive care unit residence were independently associated with time to nephrotoxicity.	Creatinine	111-121	cytochrome c oxidase subunit 8A	Homo sapiens	7-10
18355769-5	2008	Univariate and stepwise regression analysis demonstrated the MMP-2 level was associated with cystatin C level (P &lt; 0.001), creatinine level (P = 0.036), proteinuria (P = 0.043), posttransplant days (P = 0.025), and posttransplant diabetes mellitus (P = 0.03).	Creatinine	126-136	matrix metallopeptidase 2	Homo sapiens	61-66
18295055-18	2008	An equation including serum cystatin C level in combination with serum creatinine level, age, sex, and race provides the most accurate estimates.	Creatinine	71-81	cystatin C	Homo sapiens	28-38
18307770-5	2008	The cystatin C concentration (1.36 mg/L) was higher and gave an estimated GFR which was lower (51 mL/min/1.73 m2), while the creatinine concentration was lower (36 mumol/L) and gave a corresponding creatinine-estimated GFR that was higher (145 mL/min/1.73 m2) than the iohexol-estimated GFR (121 mL/min/1.73 m2) during the hyperthyroid period.	Creatinine	198-208	cystatin C	Homo sapiens	4-14
25380936-10	2014	In multivariate analysis, only creatinine was found to be a predictor of YKL-40 (beta = 0.59; P = .02), explaining 56% of the variation in YKL-40 levels in heart allograft recipients.	Creatinine	31-41	chitinase 3 like 1	Homo sapiens	139-145
24837348-4	2014	RESULTS: In multivariable Cox proportional hazards regression analysis, NT-proBNP or BNP levels in the upper 50th percentile were the strongest predictor of ICD therapy after adjustment for sex, age, left ventricular ejection fraction, New York Heart Association class, history of coronary artery disease, blood urea nitrogen, creatinine clearance, and history of atrial fibrillation (hazard ratio [HR] 5.75, P &lt; .001 for NT-proBNP; HR 3.40, P = .01 for BNP).	Creatinine	327-337	natriuretic peptide B	Homo sapiens	85-88
18199799-6	2008	After I/R injury, elevations in serum creatinine and urea were attenuated in GC-G(-/-) mice compared with wild-type controls, and this correlated with less tubular disruption, less tubular cell apoptosis, and less caspase-3 activation.	Creatinine	38-48	glucagon	Mus musculus	77-81
18609082-8	2008	For persons with impaired physical functioning, the odds ratio for belonging to the highest compared to the lowest cystatin C quintile was 7.04 (95% confidence interval 3.49-14.9; p&lt;0.001), whereas for creatinine and estimated GFR this difference was not significant.	Creatinine	205-215	cystatin C	Homo sapiens	115-125
17898039-13	2007	Urinary MMP-2 and TIMP-1 levels showed a positive correlation with tubulointerstitial damage and a negative correlation with creatinine clearance.	Creatinine	125-135	matrix metallopeptidase 2	Homo sapiens	8-13
17898039-15	2007	However, urinary MMP-2 activity and TIMP-1 levels reflect tubulointerstitial damage and correlate negatively with creatinine clearance at biopsy.	Creatinine	114-124	matrix metallopeptidase 2	Homo sapiens	17-22
18345256-9	2007	RESULTS: Urinary clusterin values correlated with urinary total protein concentrations (r = 0.28; p = 0.018), total protein/creatinine index (r = 0.26; p = 0.02).	Creatinine	124-134	clusterin	Homo sapiens	17-26
18345256-13	2007	CONCLUSIONS: A positive correlation exists between urinary clusterin and urinary total protein and total protein/ creatinine index.	Creatinine	114-124	clusterin	Homo sapiens	59-68
17903694-8	2007	Using logistic regression, creatinine clearance interacted with the relationship between the AGTR1 A1166C polymorphism and LVH (beta, -0.19; P = .033).	Creatinine	27-37	angiotensin II receptor type 1	Homo sapiens	93-98
25154231-4	2014	The serum creatinine level in these CS patients gradually exceeded the reference level from 5 to 7 years of age, after correcting for body length.	Creatinine	10-20	citrate synthase	Homo sapiens	36-38
25154231-6	2014	Thus, we conclude that the serum creatinine level, following correction by body length, is very useful for the evaluation of renal function in CS.	Creatinine	33-43	citrate synthase	Homo sapiens	143-145
24536044-12	2014	Serum connective tissue growth factor level was a risk factor for doubling of serum creatinine in lupus nephritis (p&lt;0.001, hazard ratio = 1.015, 95% confidence intervals 1.008-1.022) in univariate analysis.	Creatinine	84-94	cellular communication network factor 2	Homo sapiens	6-37
24536044-13	2014	CONCLUSIONS: Serum connective tissue growth factor levels were significantly higher in lupus and correlated with chronic renal interstitial injury and doubling of serum creatinine in patients with lupus nephritis.	Creatinine	169-179	cellular communication network factor 2	Homo sapiens	19-50
24676352-10	2014	Levels of CTGF were negatively correlated with the estimated glomerular filtration rate (eGFR) and the methylation level of the promoter, while they were positively correlated with age, urinary albumin-to-creatinine ratio (UACR), blood urea nitrogen, creatinine, fasting blood sugar and postprandial blood glucose.	Creatinine	205-215	cellular communication network factor 2	Homo sapiens	10-14
24676352-10	2014	Levels of CTGF were negatively correlated with the estimated glomerular filtration rate (eGFR) and the methylation level of the promoter, while they were positively correlated with age, urinary albumin-to-creatinine ratio (UACR), blood urea nitrogen, creatinine, fasting blood sugar and postprandial blood glucose.	Creatinine	251-261	cellular communication network factor 2	Homo sapiens	10-14
24836755-11	2014	CONCLUSIONS: In infants aged 0-2 months with UTI, increased blood creatinine value at admission was associated with bacteremia.	Creatinine	66-76	alpha-1-microglobulin/bikunin precursor	Homo sapiens	45-48
25520843-9	2014	Cystatin C is a novel agent that offers a sure promise as it is least influenced by factors that affect serum creatinine to a major extent.	Creatinine	110-120	cystatin C	Homo sapiens	0-10
24485147-9	2014	The 2012 CKD-EPI creatinine-cystatin C equation is more accurate than the 2009 CKD-EPI creatinine and 2012 CKD-EPI cystatin C equations and is useful as a confirmatory test for decreased eGFR as determined by serum creatinine-based eGFR.	Creatinine	17-27	cystatin C	Homo sapiens	28-38
24610925-5	2014	Estimated GFR (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration eGFR creatinine-cystatin C (eGFRcreat-cys) equation.	Creatinine	101-111	cystatin C	Homo sapiens	112-122
23744636-0	2014	Performance of chronic kidney disease epidemiology collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis.	Creatinine	65-75	cystatin C	Homo sapiens	76-86
17554073-8	2007	Treatment with the CTGF ASO for 8 wk reduced serum creatinine and attenuated urinary albuminuria and proteinuria in diabetic db/db mice, a model of type 2 DN.	Creatinine	51-61	cellular communication network factor 2	Mus musculus	19-23
17127700-7	2007	The reversible effect of CsA was quantified as a 0.11+/-0.07 mg/dl increase in creatinine/100 mg CsA/day (P&lt;0.001) and a 6.0+/-3.7 ml/min/1.73 m(2) decrease in GFR/100 mg CsA/day (P&lt;0.0001).	Creatinine	79-89	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	25-28
17127700-8	2007	The irreversible effect was quantified as a 0.03+/-0.05 mg/dl increase in creatinine/100 g cumulative CsA received (P&lt;0.007) and a decrease of 3.3+/-3.9 ml/min/1.73 m(2) GFR/100 g CsA.	Creatinine	74-84	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	102-105
23744636-3	2014	Performance of the new CKD-EPI creatinine-cystatin C equation (2012) was superior to previous creatinine- or cystatin C-based GFR equations.	Creatinine	31-41	cystatin C	Homo sapiens	42-52
23744636-4	2014	To evaluate the performance of the CKD-EPI creatinine-cystatin C equation in subjects with cirrhosis, we compared it to GFR measured by nonradiolabeled iothalamate plasma clearance (mGFR) in 72 subjects with cirrhosis.	Creatinine	43-53	cystatin C	Homo sapiens	54-64
23744636-5	2014	We compared the "bias," "precision," and "accuracy" of the new CKD-EPI creatinine-cystatin C equation to that of 24-hour urinary creatinine clearance (CrCl), Cockcroft-Gault (CG), and previously reported creatinine- and/or cystatin C-based GFR-estimating equations.	Creatinine	71-81	cystatin C	Homo sapiens	82-92
23744636-6	2014	Accuracy of CKD-EPI creatinine-cystatin C equation as quantified by root mean squared error of difference scores (differences between mGFR and estimated GFR [eGFR] or between mGFR and CrCl, or between mGFR and CG equation for each subject) (RMSE = 23.56) was significantly better than that of CrCl (37.69, P = 0.001), CG (RMSE = 36.12, P = 0.002), and GFR-estimating equations based on cystatin C only.	Creatinine	20-30	cystatin C	Homo sapiens	31-41
23744636-8	2014	However, for 23.61% of the subjects, GFR estimated by CKD-EPI creatinine-cystatin C equation differed from the mGFR by more than 30%.	Creatinine	62-72	cystatin C	Homo sapiens	73-83
23744636-9	2014	CONCLUSION: The diagnostic performance of CKD-EPI creatinine-cystatin C equation (2012) in patients with cirrhosis was superior to conventional equations in clinical practice for estimating GFR.	Creatinine	50-60	cystatin C	Homo sapiens	61-71
24825263-9	2014	Cystatin C-based equation had less bias (1.9 vs. 12.4 ml/min/1.73 m2), and higher precision (13.1 vs. 25.6 mL/min/1.73 m2) and accuracy (92.1% vs. 75.7%) than creatinine-based equation.	Creatinine	159-169	cystatin C	Homo sapiens	0-10
24151105-11	2014	Serum PAPP-A correlated positively with urea, creatinine, systolic and diastolic blood pressure (DBP).	Creatinine	46-56	pappalysin 1	Homo sapiens	6-12
25911852-9	2014	The results suggest that cystatin C may be a marker for metabolic syndrome and may identify a certain degree of renal dysfunction even when serum creatinine does not exceed normal level.	Creatinine	146-156	cystatin C	Homo sapiens	25-35
24344833-7	2014	The rest of seven cases were asymptomatic or minimally uncomfortable, who were found with elevated serum creatinine (Scr) in the follow up of CGN.	Creatinine	105-115	cingulin	Homo sapiens	142-145
24004970-7	2014	The changes in ACE and ACE2 in CKD were associated with the plasma creatinine concentration in dogs.	Creatinine	67-77	angiotensin converting enzyme 2	Canis lupus familiaris	23-27
17264017-10	2007	The 90% decrease in creatinine clearance after SMA-SRACR was greater than the 60% decrease after renal-SRACR.	Creatinine	20-30	survival of motor neuron 1, telomeric	Homo sapiens	47-50
17448296-5	2007	In the SSc group U-PD and U-DPD levels (nmol/mmol creatinine) were increased compared with controls (P = 0.001) and with PsV (P = 0.006).	Creatinine	50-60	uroporphyrinogen decarboxylase	Homo sapiens	17-31
24184747-10	2014	One month after transplantation the serum creatinine in anti-ETAR (+) patients (pts) was 1.86+-0.8mg/dl and 1.51+-0.5 in anti-ETAR(-) pts (p=0.009).	Creatinine	42-52	endothelin receptor type A	Homo sapiens	61-65
24409073-11	2013	CONCLUSION: Serum CysC provides early prediction of renal dysfunction in ACLF patients with a normal serum Cr level.	Creatinine	107-109	cystatin C	Homo sapiens	18-22
23677244-6	2013	Adjusting for family age at nephropathy, gender, and ancestry, presence of JCV genomic DNA in urine and APOL1 risk alleles were significantly negatively associated with elevated serum cystatin C, albuminuria (albumin-to-creatinine ratio over 30 mg/g), and kidney disease defined as an eGFR under 60 ml/min per 1.73 m(2) and/or albuminuria in an additive (APOL1 plus JCV) model.	Creatinine	220-230	apolipoprotein L1	Homo sapiens	104-109
24220609-9	2013	Conversely, the presence KIR2DS3 in the recipients combined with the presence of its HLA ligand in the donor had a detrimental effect on the trends of serum creatinine levels and eGFR trends, also confirmed by multivariate analysis.	Creatinine	157-167	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3	Homo sapiens	25-32
18022929-2	2007	Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion has been recommended as a tubular dysfunction marker that elevates before other markers, such as microalbuminuria and a decrease in creatinine clearance.	Creatinine	188-198	O-GlcNAcase	Homo sapiens	8-39
18022929-2	2007	Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion has been recommended as a tubular dysfunction marker that elevates before other markers, such as microalbuminuria and a decrease in creatinine clearance.	Creatinine	188-198	O-GlcNAcase	Homo sapiens	41-44
17564561-16	2007	Cystatin-c is far beyond the creatinine, mainly to detect slight renal alteration (sensitivity 80,4% U.S. 44,7% in men) becoming a promising alternative, that could reduce considerably hidden renal insufficiency (non detected by creatinine), although more studies are needed to confirm.	Creatinine	229-239	cystatin C	Homo sapiens	0-10
16942937-10	2006	CONCLUSIONS: Both SBP and pulse pressure were significantly associated with kidney function across a wide range of cystatin C concentrations, even in subjects with presumably normal kidney function, by creatinine-based measures.	Creatinine	202-212	cystatin C	Homo sapiens	115-125
17764210-9	2006	Few studies reported independent associations and of those that did age, female gender and creatinine levels were positively associated with BNP and NT-proBNP.	Creatinine	91-101	natriuretic peptide B	Homo sapiens	141-144
16858688-7	2006	Rats treated with CsA showed nephrotoxicity as evidenced from a significant elevation in plasma urea, creatinine, urinary N-acetyl-beta-D-glucosaminidase (beta-NAG) and a decrease in creatinine and lithium clearance.	Creatinine	102-112	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	18-21
16858688-7	2006	Rats treated with CsA showed nephrotoxicity as evidenced from a significant elevation in plasma urea, creatinine, urinary N-acetyl-beta-D-glucosaminidase (beta-NAG) and a decrease in creatinine and lithium clearance.	Creatinine	183-193	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	18-21
16858688-9	2006	The CsA-induced rise in plasma urea and creatinine and the decrease in creatinine and lithium clearance were attenuated by Spirulina.	Creatinine	40-50	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	4-7
16858688-9	2006	The CsA-induced rise in plasma urea and creatinine and the decrease in creatinine and lithium clearance were attenuated by Spirulina.	Creatinine	71-81	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	4-7
16140306-7	2006	Furthermore, patients with acute (p=0.009) or previous myocardial infarction (p&lt;0.02) or unstable angina pectoris (p&lt;0.05) had elevated levels of cathepsin S after adjustment for smoking, creatinine, cystatin C, and serum glucose.	Creatinine	194-204	cathepsin S	Homo sapiens	152-163
23699176-8	2013	Titers of anti-IL-5 antibodies and serum IL-5 concentrations were also closely associated with other risk factors, such as low-density lipoprotein cholesterol, serum creatinine, fasting plasma glucose, gender, and age, suggesting that suppressed IL-5 function mediated by autoantibodies in patients with atherosclerosis plays an important role in the disease process.	Creatinine	166-176	interleukin 5	Homo sapiens	15-19
23699176-8	2013	Titers of anti-IL-5 antibodies and serum IL-5 concentrations were also closely associated with other risk factors, such as low-density lipoprotein cholesterol, serum creatinine, fasting plasma glucose, gender, and age, suggesting that suppressed IL-5 function mediated by autoantibodies in patients with atherosclerosis plays an important role in the disease process.	Creatinine	166-176	interleukin 5	Homo sapiens	41-45
23699176-8	2013	Titers of anti-IL-5 antibodies and serum IL-5 concentrations were also closely associated with other risk factors, such as low-density lipoprotein cholesterol, serum creatinine, fasting plasma glucose, gender, and age, suggesting that suppressed IL-5 function mediated by autoantibodies in patients with atherosclerosis plays an important role in the disease process.	Creatinine	166-176	interleukin 5	Homo sapiens	41-45
23950936-6	2013	Plasma creatinine was higher in diabetic CTGF+/+ group (11.7+-1.2 vs 7.9+-0.6 micromol/L p&lt;0.01), while urinary albumin excretion and mesangial expansion were reduced in diabetic CTGF+/- animals.	Creatinine	7-17	cellular communication network factor 2	Mus musculus	41-45
16687626-7	2006	Multiple linear regression analysis revealed that age, creatinine clearance, and high-sensitivity C-reactive protein all were independently associated with OPG (R2=0.42).	Creatinine	55-65	TNF receptor superfamily member 11b	Homo sapiens	156-159
27293567-6	2013	RESULTS: Metabolic syndrome established at the diagnosis or during follow-up of IgAN patients was significantly associated with the primary renal end point (unadjusted hazard ratio of doubling of serum creatinine, 95% confidence interval: 1.96 (1.17-1.33, p = 0.011).	Creatinine	202-212	IGAN1	Homo sapiens	80-84
23834818-9	2013	Cystatin C was independently associated with cardiovascular events (hazard ratio 1.50 (95% CI: 1.27-1.77)) and all-cause mortality (hazard ratio 1.62 (95% CI: 1.38-1.90)).Creatinine was only associated with all-cause mortality, while eGFR was not associated with any of the outcomes.	Creatinine	171-181	cystatin C	Homo sapiens	0-10
23837450-6	2013	RESULTS: Urinary KIM-1/creatinine (Cr) was significantly decreased in patients with IgAN after treatment compared to baseline (P &lt; 0.0001, 1.16 [0.51-1.83] vs 0.26 [0.12-0.65] ng/mg).	Creatinine	23-33	IGAN1	Homo sapiens	84-88
23552723-5	2013	MIF was elevated significantly at baseline compared with follow-up at 3 and 6 months (8,618 pg/mL versus 5,696 and 6,212 respectively; P &lt; 0.002) but did not correlate to CRP, GC dose, creatinine or organ involvement.	Creatinine	188-198	macrophage migration inhibitory factor	Homo sapiens	0-3
23332602-2	2013	Urinary cystatin C (CysC) level is a biomarker of proximal tubule function and may increase earlier in AKI than serum creatinine level.	Creatinine	118-128	cystatin C	Homo sapiens	8-18
16106037-9	2006	The same ischemic insult induced acute renal failure in Bid-deficient mice, which was nonetheless less severe than the wild-type, showing 1.3 mg/dl serum creatinine.	Creatinine	154-164	BH3 interacting domain death agonist	Mus musculus	56-59
17078475-0	2006	Comparison of estimated glomerular filtration rates from serum creatinine and cystatin C in patients with impaired creatinine production.	Creatinine	115-125	cystatin C	Homo sapiens	78-88
16512441-6	2006	Of prognostic significance in relation to renal survival estimated by Cox in 21 patients in multifactorial analysis were blood creatinine level, glomerular filtration rate, the patient"s age, SBP duration for day, night and 24 hours.	Creatinine	127-137	cytochrome c oxidase subunit 8A	Homo sapiens	70-73
24648949-5	2013	In THM, the urinary albumin/creatinine (Alb/Cr) ratio was elevated with age without a concomitant increase in the plasma Cr concentration.	Creatinine	28-38	albumin	Mus musculus	40-43
16504678-7	2006	The risk for accelerated graft loss in the course of IgAN was associated with graft dysfunction (RR = 2.16 for additional 1 mg/dL of serum creatinine at glomerulonephritis presentation; P &lt; .03, 95% CI 1.2 to 4.36) and intense proteinuria as evidenced by a RR = 4.67 for the presence of the nephrotic syndrome (P &lt; .05, 95% CI 0.95 to 22.8).	Creatinine	139-149	IGAN1	Homo sapiens	53-57
16817048-11	2006	Significant correlation was found between cysC and Cr in umbilical cord blood (r = 0.30, P = 0.006) and day 3 blood samples (r = 0.37, P = 0.001).	Creatinine	51-53	cystatin C	Homo sapiens	42-46
16229907-10	2005	The rates of creatinine (Cr), sodium (Na), and protein excretions of the animals infused leptin were significantly increased.	Creatinine	13-23	leptin	Rattus norvegicus	89-95
16229907-10	2005	The rates of creatinine (Cr), sodium (Na), and protein excretions of the animals infused leptin were significantly increased.	Creatinine	25-27	leptin	Rattus norvegicus	89-95
16229907-16	2005	CONCLUSIONS: Our results indicate that pathophysiological increases in plasma leptin concentrations cause enhanced renal Na, Cr and protein excretions, and high circulating ET-1 levels.	Creatinine	125-127	leptin	Rattus norvegicus	78-84
16397385-3	2005	Urinary TGF-beta1 levels (TGF-beta1/creatinine ratio) were significantly increased compared with healthy controls, whereas serum levels of TGF-beta1 were not.	Creatinine	36-46	transforming growth factor beta 1	Felis catus	8-17
16319383-6	2005	FOXP3 mRNA levels were inversely correlated with serum creatinine levels measured at the time of biopsy in the acute-rejection group (Spearman"s correlation coefficient = -0.38, P=0.02) but not in the group with chronic allograft nephropathy or the group with normal biopsy results.	Creatinine	55-65	forkhead box P3	Homo sapiens	0-5
16287273-1	2005	Reduction of diferrous dithiolato complexes with hydride donor reagents affords the first example of the previously elusive terminal diferrous hydride, [Fe2(edt)(mu-CO)(H)(CO)(PMe3)4]PF6 (edt = S2C2H4).	Creatinine	49-56	sperm associated antigen 17	Homo sapiens	183-186
16386520-13	2005	Alternatively, a protocol based on anti-IL-2R induction therapy combined with SRL, MMF, and prednisone has shown an efficient prevention of acute rejection, higher creatinine clearance and lower rate of CAN in comparison with a group treated with CNI.	Creatinine	164-174	interleukin 2 receptor subunit alpha	Homo sapiens	40-45
23195037-6	2013	Moreover, renal restricted subcapsular infusion of Snx5-specific siRNA (vs. mock siRNA) decreases sodium excretion (Delta=-0.2+-0.005 mEq/mg creatinine) and further elevates the systolic blood pressure (Delta=48+-5 mm Hg) in spontaneously hypertensive rats, indicating that SNX5 depletion impairs renal D1R function.	Creatinine	141-151	sorting nexin 5	Rattus norvegicus	51-55
15982481-6	2005	CysC showed higher non-parametric correlation (r=0.805) to the iopromide clearance compared to crea (r=0.652) and to the estimated GFR according to the Cockcroft-Gault formula (r=0.690), which underestimated true GFR systematically.	Creatinine	95-99	cystatin C	Homo sapiens	0-4
15701814-11	2005	However, animals treated with the p38 MAPK inhibitor SKF-86002 along with cisplatin showed less renal dysfunction (BUN: 55 +/- 14 mg/dl, creatinine: 0.3 +/- 0.02 mg/dl, P &lt; 0.05), less severe histological damage, and fewer leukocytes compared with cisplatin+vehicle-treated animals.	Creatinine	137-147	mitogen-activated protein kinase 14	Mus musculus	34-42
15743271-6	2005	Kaplan-Meier analysis curves for the subgroup with supramedian creatinine levels (225 micromol/l) showed significant separation of the curves stratified for plasma N-BNP levels above and below the group median (291 pmol/l) for all end points.	Creatinine	63-73	natriuretic peptide B	Homo sapiens	166-169
23408169-4	2013	Acute injury was promptly followed by a rise in serum creatinine in both wild-type and netrin-1 transgenic animals.	Creatinine	54-64	netrin 1	Mus musculus	87-95
16047644-11	2005	Serum cystatin C significantly increased already one, serum creatinine two days after nephrectomy.	Creatinine	60-70	cystatin C	Homo sapiens	6-16
23429061-9	2013	After controlling for potential confounding factors, the creatinine-adjusted urine NAG concentrations were shown to be influenced by the GG genotype of rs8052394 in exon 3, and were weakly increased with TWICL.	Creatinine	57-67	O-GlcNAcase	Homo sapiens	83-86
23426640-3	2013	Both CYP2C8*3 and donor age greater than 48 years were associated to a higher incidence of delayed graft function (DGF) [OR = 2.01 (1.1-4.1), P = .04 and 5.14 (2.4-10.9), P &lt; .0001; respectively] and worse creatinine clearance 1 year after grafting (P &lt; .05 and P &lt; .001, respectively).	Creatinine	209-219	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	5-11
15888484-9	2005	Abcc6-/- mice developed a 25% reduction in plasma HDL cholesterol and an increase in plasma creatinine levels, which may be due to impaired kidney function.	Creatinine	92-102	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	0-5
15780085-7	2005	Consequently, the midkine antisense ODN-treated animals exhibited less severe renal damage than untreated or midkine sense ODN-treated animals 2 days after I/R as assessed by morphologic criteria and blood urea nitrogen (BUN) and serum creatinine levels.	Creatinine	236-246	midkine	Mus musculus	18-25
15683714-8	2005	In univariate analysis, urinary F2-isoprostane levels were significantly lower in the presence of the G allele of AGTR1/A-153G (56 +/- 17 vs 76 +/- 39 pmol/mmol creatinine; P &lt; 0.001, and P &lt; 0.01 after Bonferroni correction for 10 tests).	Creatinine	161-171	angiotensin II receptor type 1	Homo sapiens	114-120
15689404-5	2005	When pretreated with G-CSF or G-CSF + M-CSF, the mice showed longer survival and lower serum creatinine and blood urea nitrogen levels than mice that had been received injections of M-CSF or saline.	Creatinine	93-103	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	21-26
15689404-5	2005	When pretreated with G-CSF or G-CSF + M-CSF, the mice showed longer survival and lower serum creatinine and blood urea nitrogen levels than mice that had been received injections of M-CSF or saline.	Creatinine	93-103	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	30-35
15852743-2	2005	METHODS: A cross sectional comparative study on 50 live related renal transplant recipients on CSA therapy with serum creatinine &lt; 2.0 mg/dl and 30 healthy controls.	Creatinine	118-128	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	95-98
15716560-7	2005	Patients with NT-pro-BNP levels in the highest quartile were older, had a lower left ventricular ejection fraction (LVEF) and a lower creatinine clearance rate, and were more likely to have a history of myocardial infarction, clinically significant coronary artery disease, and diabetes than patients with NT-pro-BNP levels in the lowest quartile.	Creatinine	134-144	natriuretic peptide B	Homo sapiens	21-24
23302768-8	2013	The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine.	Creatinine	173-183	angiopoietin 2	Homo sapiens	4-9
23302768-8	2013	The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine.	Creatinine	173-183	angiopoietin 1	Homo sapiens	11-16
23679242-7	2013	Creatinine clearance significantly correlated with AFP (P&lt;0.001, r=0.53) and CA15-3 (p=0.00, r=-0.412), but not CA19-9 (P=0.089, r=-0.171).	Creatinine	0-10	mucin 1, cell surface associated	Homo sapiens	80-86
23152489-8	2013	Mon2 count remained an independent negative predictor of combined death and rehospitalization after adjustment for age, left ventricular ejection fraction, creatinine, and brain natriuretic peptide (hazard ratio, 0.58 [95% CI, 0.34-0.98]; P=0.043).	Creatinine	156-166	MON2 homolog, regulator of endosome-to-Golgi trafficking	Homo sapiens	0-4
15691269-3	2005	Multivariate analysis revealed a significant correlation of BNP with female recipient gender (P = 0.006), time post-transplant (P =0.006), donor age (P = 0.007), angiographic signs of transplant vasculopathy (TVP) (P = 0.03), serum creatinine level (P = 0.04), and a strong trend for diastolic dysfunction (P = 0.09).	Creatinine	232-242	natriuretic peptide B	Homo sapiens	60-63
15653026-5	2005	Each standard deviation increase in cystatin-C (0.35 mg/l) was associated with a 31% greater adjusted mortality risk (95% confidence interval [CI] 20% to 43%, p &lt; 0.001), whereas each standard deviation increase in creatinine (0.39 mg/dl) was associated with a 17% greater adjusted mortality risk (95% CI 1% to 36%, p = 0.04).	Creatinine	218-228	cystatin C	Homo sapiens	36-46
15593034-0	2004	Does cystatin C improve the precision of Cockcroft and Gault"s creatinine clearance estimation?	Creatinine	63-73	cystatin C	Homo sapiens	5-15
15593034-2	2004	This study aimed at verifying whether the clinical practice of associating cystatin C determination with serum creatinine (Cr) improved the ability of the Cockcroft and Gault formula to estimate creatinine clearance (CrCl).	Creatinine	195-205	cystatin C	Homo sapiens	75-85
15327406-12	2004	Serum cystatin C demonstrated a high diagnostic value to detect ARF as indicated by area under the curve of the ROC analysis of 0.82 and 0.97 on the two days before the R-criteria was fulfilled by creatinine.	Creatinine	197-207	cystatin C	Homo sapiens	6-16
15327406-14	2004	Cystatin C also performed excellently, detecting ARF defined by the I- and F-criteria two days prior to creatinine, and moderately well predicting renal replacement therapy in the further course of ARF.	Creatinine	104-114	cystatin C	Homo sapiens	0-10
24143084-0	2013	Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly?	Creatinine	57-67	cystatin C	Homo sapiens	68-78
24143084-1	2013	BACKGROUND: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation in a cohort of elderly Chinese participants.	Creatinine	116-126	cystatin C	Homo sapiens	127-137
24143084-3	2013	Performance of the CKD-EPI creatinine-cystatin C equation was compared with the Cockcroft-Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation.	Creatinine	27-37	cystatin C	Homo sapiens	38-48
24143084-5	2013	Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine-cystatin C equation (beta=-0.184 and -0.113, P&lt;0.001 and P=0.02, respectively).	Creatinine	118-128	cystatin C	Homo sapiens	129-139
24143084-6	2013	CONCLUSION: Compared with the creatinine-based equations, the CKD-EPI creatinine-cystatin C equation is more suitable for the elderly Chinese population.	Creatinine	70-80	cystatin C	Homo sapiens	81-91
24143084-7	2013	However, the cost-effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered.	Creatinine	47-57	cystatin C	Homo sapiens	58-68
23329885-5	2013	Serum creatine and creatinine increased significantly from before to after administration in GAA-supplemented participants (P &lt; 0.05).	Creatinine	19-29	alpha glucosidase	Homo sapiens	93-96
23469280-10	2013	CONCLUSION: Our results suggest that semaphorin 3A is an early, predictive biomarker in experimental and pediatric AKI, and may allow for the reliable early diagnosis and prognosis of AKI after CPB, much before the rise in serum creatinine.	Creatinine	229-239	semaphorin 3A	Homo sapiens	37-50
22987920-6	2012	In PE, urine plasmin(ogen): creatinine ratio was elevated 40-fold (geometric mean, 160 versus 4 microg/g; P&lt;0.0001) and urine aldosterone: creatinine ratio was suppressed to 25% of Ctrl (geometric mean, 27 versus 109 microg/g; P&lt;0.001).	Creatinine	28-38	plasminogen	Homo sapiens	13-20
22387348-6	2012	Multivariate Cox regression on the training set identified creatinine &lt;2 mg/dL and platelet count &gt;20 x 10(9)/L as significant predictors of better OS.	Creatinine	59-69	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
15248218-9	2004	In a survival analysis, patients homozygous for CYP2B6*5 (n = 3) or CYP2C19*2 (n = 4) had a higher probability of reaching ESRD (P = 0.0005) and of doubling the creatinine level (P = 0.0005) as well as a trend toward a lower probability of achieving a complete renal response (P = 0.051).	Creatinine	161-171	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	48-54
15167345-10	2004	Corrected creatinine clearance negatively correlated significantly with both cystatin C and creatinine levels (r = -0.622, P &lt; 0.001; r = -0.346, P = 0.045, respectively) before chemotherapy and also 1 month after chemotherapy (r = -0.577, P &lt; 0.001; r = -0.45, P = 0.009, respectively).	Creatinine	10-20	cystatin C	Homo sapiens	77-87
15312444-8	2004	Serum OPG was positively related with urinary NTx/creatinine.	Creatinine	50-60	TNF receptor superfamily member 11b	Homo sapiens	6-9
14966969-4	2004	Protonation reaction of the new hydrides with Bronsted acid was studied and led to dicationic [Ru(eta2-H2)(N-N)P3]2+ (9, 10) and [Ru(eta(2-H2)(bpy)2P]2+ (11) dihydrogen derivatives.	Creatinine	32-40	DNA polymerase iota	Homo sapiens	98-102
15013124-7	2004	In multivariate analysis, overall diastolic stage, LVEF, RV systolic dysfunction, mitral regurgitation (MR) severity, age and creatinine clearance were independent predictors of BNP levels (model fit r = 0.8, p &lt; 0.001).	Creatinine	126-136	natriuretic peptide B	Homo sapiens	178-181
14725938-0	2004	Relationship between plasma Cystatin C and creatinine in chronic renal diseases and Tx-transplant patients.	Creatinine	43-53	cystatin C	Homo sapiens	28-38
14725938-3	2004	This study investigated the relationship between Cyst C and creatinine (CR) in renal disease patients.	Creatinine	60-70	cystatin C	Homo sapiens	49-55
14725938-3	2004	This study investigated the relationship between Cyst C and creatinine (CR) in renal disease patients.	Creatinine	72-74	cystatin C	Homo sapiens	49-55
14725938-7	2004	RESULTS: A strong correlation was observed between Cyst C and CR (P = 0.001, r = 0.764 and P = 0.0001, r = 0.888, respectively) in prehemodialysis (pre-HD) and kidney transplantation (Tx-kidney), whereas there was a weak correlation in continuous ambulatory peritoneal dialysis (CAPD) (P = 0.05, r = 0.535).	Creatinine	62-64	cystatin C	Homo sapiens	51-57
14695889-6	2004	Animals treated with either HMGB1 antagonist were protected against the development of organ injury, as evidenced by improved levels of serum creatinine and blood urea nitrogen.	Creatinine	142-152	high mobility group box 1	Mus musculus	28-33
12965892-5	2004	In normal conditions, UT-B null mice exhibited a 44% elevation in plasma urea (Purea), a normal creatinine clearance, but a 25% decrease in urea clearance, with no change in that of sodium and potassium.	Creatinine	96-106	solute carrier family 14 (urea transporter), member 1	Mus musculus	22-26
15478910-4	2004	A 6-month serum creatinine &lt; 130 mmol/L was less frequent in older recipients (RR 1.20; p=0.004).	Creatinine	16-26	ribonucleotide reductase catalytic subunit M1	Homo sapiens	82-86
22899766-5	2012	CysC levels strongly correlated with creatinine (r=0.73), blood urea nitrogen (r=0.70), and estimated glomerular filtration rate by the 4-variable modification of diet in renal disease equation (r=-0.62) (all P&lt;0.001).	Creatinine	37-47	cystatin C	Homo sapiens	0-4
22745276-8	2012	Renal function (analyzed by serum creatinine levels) at the first week posttransplantation correlated with kidney injury molecule-1 and forkhead box P3 mRNA levels.	Creatinine	34-44	forkhead box P3	Homo sapiens	136-151
24062913-6	2012	Plasma BNP levels before treatment were significantly high in the lower BMI group (p&lt;0.05) and the higher Cr group (p&lt;0.01).	Creatinine	109-111	natriuretic peptide B	Homo sapiens	7-10
15065209-8	2004	In group A, serum cystatin C had no correlation to the creatinine clearance (r=0.171, P&gt;0.05) and in group B, serum cystatin C was closely correlated to the creatinine clearance (r=-0.771, P&lt;0.001).	Creatinine	160-170	cystatin C	Homo sapiens	119-129
14739577-7	2004	In the CHRI not dialyzed patients, we found a significant positive correlation between serum creatinine and PAPP-A levels (r = 0.68, p &lt; 0.05).	Creatinine	93-103	pappalysin 1	Homo sapiens	108-114
14581173-0	2003	Bias induced by the use of creatinine-corrected values in evaluation of beta2-microgloblin levels.	Creatinine	27-37	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
14629803-9	2003	Regression modelling predicted that the upper limit of normal for serum cystatin C would be exceeded as glomerular filtration rate fell below 64 mL/min/1.73 m(2), compared with 44 mL/min/1.73 m(2) for serum creatinine.	Creatinine	207-217	cystatin C	Homo sapiens	72-82
14605532-0	2003	The confounding effects of age, gender, serum creatinine, and electrolyte concentrations on plasma B-type natriuretic peptide concentrations in critically ill patients.	Creatinine	46-56	natriuretic peptide B	Homo sapiens	99-125
14605532-9	2003	BNP correlated significantly with age (r2 =.19) and creatinine (r2 =.084).	Creatinine	52-62	natriuretic peptide B	Homo sapiens	0-3
14640238-7	2003	Plasma IL-18BP was inversely correlated with creatinine clearance (correlation coefficient: -0.7479).	Creatinine	45-55	interleukin 18 binding protein	Homo sapiens	7-14
14724731-9	2003	Renal function was good, and serum creatinine was 0.5 mg/dL 6 months after the operation.	Creatinine	35-45	l(1)L6	Drosophila melanogaster	57-61
24062913-7	2012	Similarly, plasma BNP levels after treatment were high in both the lower BMI and higher Cr groups (p&lt;0.01 for both).	Creatinine	88-90	natriuretic peptide B	Homo sapiens	18-21
22976261-7	2012	There were significant inverse correlations between urine NGAL and estimated creatinine clearance in the FSGS patients both at diagnosis (r = -0.589, P = .03), and after 1 year (r = -0.76, P = .009).	Creatinine	77-87	actinin alpha 4	Homo sapiens	105-109
22537422-1	2012	BACKGROUND: Serum cystatin C level has been shown to have a stronger association with clinical outcomes than serum creatinine level.	Creatinine	115-125	cystatin C	Homo sapiens	18-28
12911562-6	2003	RESULTS: Holo-transcobalamin II levels were normal or supranormal in all patients and showed a linear association with albumin (r = 0.205, P = 0.025) and with vitamin B12 (r = 0.778, P = 0.001), but not with age, creatinine, body mass index, tHcy, ln-tHcy, vitamin B6, plasma folate, and red blood cell folate concentration.	Creatinine	213-223	transcobalamin 2	Homo sapiens	14-31
12946319-8	2003	When tumor size exceeded 8% of body weight, GHRH-treated mice showed normal urea, creatinine, and kidney volume, while controls displayed signs of renal insufficiency.	Creatinine	82-92	growth hormone releasing hormone	Mus musculus	44-48
22669302-8	2012	In patients with OI types I, III, and IV, serum creatinine, body mass index z-score, and OI severity were significant predictors of PEDF serum levels.	Creatinine	48-58	serpin family F member 1	Homo sapiens	132-136
12923438-8	2003	A significant positive correlation between the severity of CR and the degree of CD68+ macrophage infiltrate of renal parenchyma and the degree of anemia and serum creatinine level elevations were also observed.	Creatinine	163-173	CD68 molecule	Macaca mulatta	80-84
22809602-5	2012	Serum creatinine and cholesterol levels were higher in the IgAN group than in the HSPN group (P&lt;0.05).	Creatinine	6-16	IGAN1	Homo sapiens	59-63
12900807-7	2003	At the end of the study, urinary protein excretion and NAG-creatinine ratios decreased in the active group from 920 +/- 522 mg/d and 14.3 +/- 16.9 U/g to 803 +/- 523 mg/d (P &lt; 0.001) and 10.5 +/- 9.3 U/g (P &lt; 0.05), respectively.	Creatinine	59-69	O-GlcNAcase	Homo sapiens	55-58
12681452-9	2003	Plasma BNP concentration correlated positively with age (r = 0.31, P = 0.001), serum creatinine level (r = 0.23, P = 0.02), and the activities of daily living (r = 0.36, P = 0.0001).	Creatinine	85-95	natriuretic peptide B	Homo sapiens	7-10
12693733-3	2003	Until further data from well-designed, prospective, randomized trials are available, the use of aldosterone receptor antagonists should be restricted to patients with severe or progressive heart failure caused by systolic left ventricular dysfunction in whom serum creatinine level is &lt; or = 2.0 mg/dL and serum potassium levels are &lt; 5.0 meq/L at baseline.	Creatinine	265-275	nuclear receptor subfamily 3 group C member 2	Homo sapiens	96-116
22338083-3	2012	Here, we demonstrate specific uptake of creatinine into mouse mOat1- and mOat3-microinjected Xenopus laevis oocytes at a concentration of 10 muM (i.e., similar to physiological plasma levels), which was inhibited by both probenecid and cimetidine, prototypical competitive inhibitors of organic anion and cation transporters, respectively.	Creatinine	40-50	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	62-67
22338083-9	2012	The results are consistent with a contribution of OAT3 and possibly OAT1 to renal creatinine secretion in mice.	Creatinine	82-92	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	68-72
12575027-4	2003	RESULTS: hCG correlated inversely with creatinine clearance (r = -0.345; p = 0.002) and directly with alpha-fetoprotein (r = 0.499; p = 0.003).	Creatinine	39-49	glycoprotein hormones, alpha polypeptide	Homo sapiens	9-12
22309414-9	2012	Serum cystatin C showed significant correlation with serum creatinine (r = 0.864; P &lt; .001).	Creatinine	59-69	cystatin C	Homo sapiens	6-16
22016505-7	2012	Higher galectin-3 levels were associated with other measures of heart failure severity, including higher New York Heart Association class, lower systolic blood pressure, higher creatinine, higher amino-terminal proB-type natriuretic peptide (NTproBNP), and lower maximal oxygen consumption.	Creatinine	177-187	galectin 3	Homo sapiens	7-17
22710867-7	2012	There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041).	Creatinine	189-199	microRNA 377	Homo sapiens	266-273
23446785-8	2012	More recently, the combined creatinine-cystatin C equation was shown to perform better than equations based on either of these markers alone in diagnosing CKD, even in older patients.	Creatinine	28-38	cystatin C	Homo sapiens	39-49
21538059-5	2012	In particular, the side chain of the C-terminal Y303 in Anabaena FNR appears key to providing the optimum geometry by reducing the stacking probability between the isoalloxazine and nicotinamide rings, thus providing the required co-linearity and distance among the N5 of the flavin cofactor, the C4 of the coenzyme nicotinamide and the hydride that has to be transferred between them.	Creatinine	337-344	ferredoxin reductase	Homo sapiens	65-68
21831111-2	2011	In patients with renal disease, cystatin C has emerged as a new biomarker which in contrast to creatinine (Cr) is sensitive to minor changes in glomerular filtration rate (GFR).	Creatinine	107-109	cystatin C	Homo sapiens	32-42
12697975-7	2003	Plasma NT-proANP and BNP correlated positively with aging and serum creatinine concentration and inversely with left ventricular diastolic filling.	Creatinine	68-78	natriuretic peptide B	Homo sapiens	21-24
12697978-8	2003	RESULTS: Serum creatinine correlated well with cystatin C (r = 0.84; p &lt; 0.0001).	Creatinine	15-25	cystatin C	Homo sapiens	47-57
14610342-9	2003	The TF and TFPI levels depend significantly on the renal function, as assessed by serum creatinine, and on some metabolic disorders.	Creatinine	88-98	tissue factor pathway inhibitor	Homo sapiens	11-15
12759582-1	2003	BACKGROUND: Elevated serum creatinine is associated with poor outcome in IgA nephropathy (IgAN).	Creatinine	27-37	IGAN1	Homo sapiens	90-94
12759583-3	2003	If cystatin C were also a sensitive marker of GFR in pre-dialysis patients, then it could be expected that, for the same degree of a decrease in GFR, the increase in S(cyst) would be higher than in S(cr) because of the significant increase in tubular secretion of creatinine in residual nephrons.	Creatinine	264-274	cystatin C	Homo sapiens	3-13
21831111-10	2011	Cr and cystatin C increased postoperatively to peak on days 2 and 3, respectively (Cr(PreOp) 31 +- 6.9 vs Cr(Day 2) 36.9 +- 12.2, P = 0.03; cystatin C(Day 0) 0.83 +- 0.27 vs cystatin C(Day 3) 1.45 +- 0.53, P = 0.02).	Creatinine	0-2	cystatin C	Homo sapiens	140-150
21831111-10	2011	Cr and cystatin C increased postoperatively to peak on days 2 and 3, respectively (Cr(PreOp) 31 +- 6.9 vs Cr(Day 2) 36.9 +- 12.2, P = 0.03; cystatin C(Day 0) 0.83 +- 0.27 vs cystatin C(Day 3) 1.45 +- 0.53, P = 0.02).	Creatinine	0-2	cystatin C	Homo sapiens	140-150
21831111-10	2011	Cr and cystatin C increased postoperatively to peak on days 2 and 3, respectively (Cr(PreOp) 31 +- 6.9 vs Cr(Day 2) 36.9 +- 12.2, P = 0.03; cystatin C(Day 0) 0.83 +- 0.27 vs cystatin C(Day 3) 1.45 +- 0.53, P = 0.02).	Creatinine	83-85	cystatin C	Homo sapiens	7-17
22319062-7	2011	There was a negative correlation between plasma TFPI level and total protein and serum albumin, and there was a positive correlation between plasma TFPI level and urine protein /creatinine ratio with a statistically significant difference (p&lt; 0.05).	Creatinine	178-188	tissue factor pathway inhibitor	Homo sapiens	148-152
22172828-10	2011	Moreover, the urinary PIBF level was significantly lower among patients who had increased creatinine and urea nitrogen levels in blood samples (P&lt;.05 and P&lt;.01, respectively).	Creatinine	90-100	progesterone immunomodulatory binding factor 1	Homo sapiens	22-26
22172828-12	2011	A close negative correlation was observed between urinary PIBF concentrations and blood levels of creatinine and urea nitrogen.	Creatinine	98-108	progesterone immunomodulatory binding factor 1	Homo sapiens	58-62
21926294-5	2011	In multiple linear regression, cystatin C was associated with age and serum creatinine in nondiabetic subjects and sex, age, and serum creatinine in subjects with diabetes (P &lt; 0.05).	Creatinine	76-86	cystatin C	Homo sapiens	31-41
12845219-10	2003	CONCLUSION: Serum cystatin C levels correlate significantly closer to accurate measurements of GFR and are significantly more sensitive to detect early GFR impairment than enzymatic measurements of creatinine in serum.	Creatinine	198-208	cystatin C	Homo sapiens	18-28
14608855-16	2003	Beta 2 microglobulinuria have been registered at 10.97% patients with normal creatinine clearance values (Table 7).	Creatinine	77-87	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
12324495-2	2002	We developed a strategy for the detection of AGAT and GAMT defects by measurement of guanidinoacetate (GAA) and creatine plus creatinine (Cr+Crn) in biological fluids.	Creatinine	126-136	guanidinoacetate N-methyltransferase	Homo sapiens	54-58
12235535-5	2002	RESULTS: A linear relationship was found between (51)Cr-EDTA-clearance and the reciprocal values of cystatin C and creatinine.	Creatinine	115-125	cystatin C	Homo sapiens	100-110
12364852-8	2002	RESULTS: Mice given both GK1.5 and 2.43 had considerable CD4 and CD8 cell depletion but no protection of renal function after ischemia-reperfusion (I/R) as measured by the rise in serum creatinine.	Creatinine	186-196	kallikrein 1-related peptidase b1	Mus musculus	25-28
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	84-94	cystatin C	Homo sapiens	39-49
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	84-94	cystatin C	Homo sapiens	51-56
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	84-94	cystatin C	Homo sapiens	158-163
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	96-98	cystatin C	Homo sapiens	39-49
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	96-98	cystatin C	Homo sapiens	51-56
12135813-1	2002	BACKGROUND: The concentration of serum cystatin-C (Cys-C) is highly correlated with creatinine (Cr), and is mainly determined by glomerular filtration; thus, Cys-C may be an index of the glomerular filtration rate (GFR).	Creatinine	96-98	cystatin C	Homo sapiens	158-163
12135813-6	2002	RESULTS: There was a good correlation between the urinary concentrations of Cys-C and Cr in the healthy group.	Creatinine	86-88	cystatin C	Homo sapiens	76-81
12135813-10	2002	We further found that the ratio of Cys-C to Cr (CCR) is a good index of the state of Cys-C reabsorption in the proximal tubules.	Creatinine	44-46	cystatin C	Homo sapiens	85-90
12439840-3	2002	We report the case of a 24-year-old woman, with advanced IgAN (serum creatinine &gt; 3 mg/dL), who experienced remission of proteinuria and long-lasting stabilisation of renal function, after treatment with a 6-month steroid course.	Creatinine	69-79	IGAN1	Homo sapiens	57-61
11966673-12	2002	Cystatin C correlated extremely well with creatinine (r=0.93, P&lt;0.001, 95% CI 0.82, 0.97) and with creatinine clearance (r=0.67, P=0.002, 95% CI 0.3, 0.87).	Creatinine	42-52	cystatin C	Homo sapiens	0-10
11966673-12	2002	Cystatin C correlated extremely well with creatinine (r=0.93, P&lt;0.001, 95% CI 0.82, 0.97) and with creatinine clearance (r=0.67, P=0.002, 95% CI 0.3, 0.87).	Creatinine	102-112	cystatin C	Homo sapiens	0-10
11966673-15	2002	CONCLUSIONS: Serum cystatin C and serum creatinine show very similar correlations with creatinine and digoxin clearances.	Creatinine	87-97	cystatin C	Homo sapiens	19-29
11792756-6	2002	MIF was detected in urine from normal volunteers (mean +/- SD; 191 +/- 132 pg MIF/micromol creatinine).	Creatinine	91-101	macrophage migration inhibitory factor	Homo sapiens	0-3
21926620-2	2011	Here we review the performance of cystatin C and combined creatinine-cystatin C estimating equations compared to creatinine-based estimating equations in chronic and acute kidney disease.	Creatinine	58-68	cystatin C	Homo sapiens	69-79
21926620-6	2011	Cystatin C could be used in combination with creatinine as a confirmatory test for estimated GFR from creatinine.	Creatinine	102-112	cystatin C	Homo sapiens	0-10
21870328-7	2011	Moreover, the expression of nephrin and ACTN4 negatively correlated with creatinine.	Creatinine	73-83	NPHS1 adhesion molecule, nephrin	Canis lupus familiaris	28-35
21870328-8	2011	Real-time PCR analysis showed that nephrin mRNA expression in the kidneys of CKD dogs was significantly lower than that in normal animals, and negatively correlated with creatinine.	Creatinine	170-180	NPHS1 adhesion molecule, nephrin	Canis lupus familiaris	35-42
21816416-7	2011	RESULTS: Animals in which the kidney endothelium was bolstered by FLVs+VCP treatment had better renal function with a significant reduction in serum creatinine compared with vehicle controls (P &lt; 0.05).	Creatinine	149-159	valosin-containing protein	Rattus norvegicus	71-74
11784518-9	2002	There was also an association between BNP and male sex (p = 0.008), higher plasmatic creatinine (p = 0.01, r = 0.25), Iarger ventricular diameters (p = 0.0001) and higher pulmonary systolic pressure (p = 0.001, r = 0.44).	Creatinine	85-95	natriuretic peptide B	Homo sapiens	38-41
12004928-6	2002	Plasma levels of cystatin C and creatinine were found to increase with decreasing values of creatinine clearance.	Creatinine	92-102	cystatin C	Homo sapiens	17-27
21367849-10	2011	The CysC formula showed a small bias, with the best 30 and 50% accuracy and had a larger area under the curve and higher sensitivity and specificity when compared to the Cr formula and other formulas.	Creatinine	170-172	cystatin C	Homo sapiens	4-8
21402675-7	2011	Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance.	Creatinine	75-85	IGAN1	Homo sapiens	27-31
21402675-7	2011	Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance.	Creatinine	122-132	IGAN1	Homo sapiens	27-31
21942853-11	2011	The cystatin C alone and the creatinine-cystatin C combined equation allowed reliable assessment of GFR in our population of renal transplants.	Creatinine	29-39	cystatin C	Homo sapiens	40-50
21917096-18	2011	The median absolute decrease in serum creatinine and estimated glomerular filtration rate at discharge was 0 (0.2-0.7) mg/dL (P = 0.4) and 5 (-16 to 29) mL/min per 1.73 m(2) (P = 0.8), respectively.	Creatinine	38-48	H3 histone pseudogene 4	Homo sapiens	126-140
21646940-8	2011	We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories.	Creatinine	66-68	cystatin C	Homo sapiens	33-38
21692162-0	2011	The prominent enhancing effect of the cation-pi interaction on the halogen-hydride halogen bond in M1   C6H5X   HM2.	Creatinine	75-82	cholinergic receptor muscarinic 2	Homo sapiens	112-115
21934357-9	2011	We found an association of SOCS3 methylation with extramedullary manifestations (p = 0.03), plasma cell leukemia (p = 0.003), elevated LDH (p = 0.001), increased creatinine ( p = 0.01) and remarkably shortened survival (6.9 vs. 56.1 months, HR 5.9, p = 0.0007).	Creatinine	162-172	suppressor of cytokine signaling 3	Homo sapiens	27-32
21696606-8	2011	YKL-40 levels correlated with urinary albumin/creatinine-ratio in the total group of participants (r = 0.41, p &lt; 0.001).	Creatinine	46-56	chitinase 3 like 1	Homo sapiens	0-6
21292366-11	2011	The multivariable-adjusted OR for incident CKD stage 3 was 0.33 (95% CI, 0.17-0.64; P &lt; 0.001) per 1-standard deviation in log urinary CTGF level after adjustment for CKD risk factors, baseline eGFR, and baseline log urinary albumin-creatinine ratio, with similar results in participants without diabetes (n = 184).	Creatinine	236-246	cellular communication network factor 2	Homo sapiens	138-142
21367916-6	2011	The ANG II+ANG-(1-7) coinfusion group showed a lower urinary albumin/creatinine ratio increase than the ANG II group.	Creatinine	69-79	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	11-19
21441310-7	2011	In an additional study, the inhibition of COX-2 with SC-58236 for 4 wk in diabetic rats resulted in creatinine clearance rates not different from those of control rats.	Creatinine	100-110	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	42-47
12623508-11	2002	Serum creatinine level at Day 14 was lower in the M-CSF group, but not in the G-CSF group, compared with the control group.	Creatinine	6-16	colony stimulating factor 1	Rattus norvegicus	50-55
11903396-14	2001	CONCLUSIONS: Intravenous infusion of BNP and ANP both increase the urine excretion of albumin and the tubular protein alpha1 microglobulin, independent of creatinine clearance.	Creatinine	155-165	natriuretic peptide B	Homo sapiens	37-40
11472315-9	2001	There was a significant correlation between cystatin C and creatinine clearance both at diagnosis (r=-0.533, P=0.0275) and combining the initial and follow-up data (r=-0.601, P &lt; 0.01), but not between creatinine and creatinine clearance (P &gt; 0.05).	Creatinine	59-69	cystatin C	Homo sapiens	44-54
11472315-9	2001	There was a significant correlation between cystatin C and creatinine clearance both at diagnosis (r=-0.533, P=0.0275) and combining the initial and follow-up data (r=-0.601, P &lt; 0.01), but not between creatinine and creatinine clearance (P &gt; 0.05).	Creatinine	205-215	cystatin C	Homo sapiens	44-54
11472315-9	2001	There was a significant correlation between cystatin C and creatinine clearance both at diagnosis (r=-0.533, P=0.0275) and combining the initial and follow-up data (r=-0.601, P &lt; 0.01), but not between creatinine and creatinine clearance (P &gt; 0.05).	Creatinine	205-215	cystatin C	Homo sapiens	44-54
21158852-9	2011	In correlation analysis, YKL-40 was associated with urinary albumin excretion rate (AER), plasma creatinine, creatinine clearance (CC) and age.	Creatinine	97-107	chitinase 3 like 1	Homo sapiens	25-31
11485755-11	2001	Cystatin C correlated best with creatinine clearance (r=0.66), beta2-microglobulin (0.57), and serum creatinine (0.56).	Creatinine	32-42	cystatin C	Homo sapiens	0-10
11485755-11	2001	Cystatin C correlated best with creatinine clearance (r=0.66), beta2-microglobulin (0.57), and serum creatinine (0.56).	Creatinine	101-111	cystatin C	Homo sapiens	0-10
11482920-8	2001	At multivariable Cox analysis, the albumin:creatinine ratio was the strongest among several independent predictors of mortality (adjusted relative risks: 3.6 (95% CI, 2.1--6.2) on the first day, 4.9 (95% CI, 2.9--8.2) on the third day and 4.0 (95% CI, 2.3--6.8) on the seventh day).	Creatinine	43-53	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
21158852-9	2011	In correlation analysis, YKL-40 was associated with urinary albumin excretion rate (AER), plasma creatinine, creatinine clearance (CC) and age.	Creatinine	109-119	chitinase 3 like 1	Homo sapiens	25-31
21292309-6	2011	We found that decreased expression of GZF1 was associated with an increase in tubulointerstitial damage and serum creatinine levels.	Creatinine	114-124	GDNF inducible zinc finger protein 1	Homo sapiens	38-42
11466665-0	2001	Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine.	Creatinine	137-147	cystatin C	Homo sapiens	6-16
11435884-7	2001	RESULTS: The mean urinary bikunin-to-creatinine ratio plus or minus standard deviation in stone formers was significantly elevated compared with that in healthy male and female controls (52.9 +/- 46.0 microg./mg.	Creatinine	37-47	alpha-1-microglobulin/bikunin precursor	Homo sapiens	26-33
11455258-7	2001	RESULTS: MIF was readily detected in the urine of normal healthy controls (106+/-61 pg/micromol creatinine).	Creatinine	96-106	macrophage migration inhibitory factor	Homo sapiens	9-12
11455258-8	2001	In the prospective study, the urinary MIF concentration was increased substantially on day 1 posttransplantation and subsequently fell in parallel with the serum creatinine.	Creatinine	162-172	macrophage migration inhibitory factor	Homo sapiens	38-41
11447373-4	2001	RESULTS: In NR, pre- and postcompetition concentrations for EPI were significantly higher under tournament conditions (T: 1.33+/-0.65 and 3.66+/-2.51 microg/100 mg creatinine vs P: 0.61+/-0.39 and 0.97+/-0.59 microg/100 mg creatinine).	Creatinine	164-174	tissue factor pathway inhibitor	Homo sapiens	60-63
11447373-4	2001	RESULTS: In NR, pre- and postcompetition concentrations for EPI were significantly higher under tournament conditions (T: 1.33+/-0.65 and 3.66+/-2.51 microg/100 mg creatinine vs P: 0.61+/-0.39 and 0.97+/-0.59 microg/100 mg creatinine).	Creatinine	223-233	tissue factor pathway inhibitor	Homo sapiens	60-63
11447373-8	2001	The Davis-Cup-Players showed intra-individually constant but inter-individually different concentrations of EPI (A= 2.2+/-0.5 vs B= 7.0+/-0.8 microg/100 mg creatinine), NE (A= 7.4+/-2.2 vs B= 15.5+/-3.2 microg/100 mg creatinine) and the ratio of NE/EPI (A= 3.7+/-2.2 vs B= 2.2+/-0.7).	Creatinine	156-166	tissue factor pathway inhibitor	Homo sapiens	108-111
11283152-5	2001	Unexpectedly, nephritis was more severe in MMP9(-/)- than in control mice, as attested by levels of serum creatinine and albuminuria, and the extent of crescents and fibrin deposits.	Creatinine	106-116	matrix metallopeptidase 9	Mus musculus	43-47
11260394-13	2001	GFRs and creatinine clearance were also decreased significantly in the ETA/ETB group.	Creatinine	9-19	endothelin receptor type A	Rattus norvegicus	71-74
11260394-13	2001	GFRs and creatinine clearance were also decreased significantly in the ETA/ETB group.	Creatinine	9-19	endothelin receptor type B	Rattus norvegicus	75-78
11260394-14	2001	Urine albumin, protein, GFR, and creatinine clearance in the ETA group, however, were not different from the sham ischemic and saline ischemic groups.	Creatinine	33-43	endothelin receptor type A	Rattus norvegicus	61-64
11336167-6	2001	The maximum postoperative increase in urine UTI excretion per day (delta-uUTImax) correlated significantly with the maximum increase in CRP and the increase in creatinine clearance.	Creatinine	160-170	alpha-1-microglobulin/bikunin precursor	Homo sapiens	44-47
11306379-4	2001	MMP-2 and MMP-9 excretion in urine samples was measured with gelatin zymography and related to the urine creatinine concentration.	Creatinine	105-115	matrix metallopeptidase 2	Homo sapiens	0-5
11306379-6	2001	RESULTS: The upper cutoff limit for MMP-2 and MMP-9 excretion was 277 microg/g creatinine and 648 microg/g creatinine, respectively.	Creatinine	79-89	matrix metallopeptidase 2	Homo sapiens	36-41
11306379-6	2001	RESULTS: The upper cutoff limit for MMP-2 and MMP-9 excretion was 277 microg/g creatinine and 648 microg/g creatinine, respectively.	Creatinine	107-117	matrix metallopeptidase 2	Homo sapiens	36-41
22737500-5	2011	RESULTS: The 1, 3, 5, 7 and 10 years graft survival rates were 96.6, 93.7, 88.9, 87.1 and 85.5 percent, respectively.Cox regression model revealed that the donor source and creatinine level at discharge were effective factors in graft survival rate in renal transplantation.	Creatinine	173-183	cytochrome c oxidase subunit 8A	Homo sapiens	117-120
11347202-8	2001	We demonstrated significant correlation between S-cystatin C and creatinine levels is both groups A (r2 = 0.865, P &lt; 0.0001) and C (r2 = 0.812, P &lt; 0.05).	Creatinine	65-75	cystatin C	Homo sapiens	50-60
11347202-11	2001	In group A there was significant correlation between S-cystatin C and creatinine clearance (r2 = 0.769, P &lt; 0.05).	Creatinine	70-80	cystatin C	Homo sapiens	55-65
11347202-12	2001	Negative correlation coefficient between calculated creatinine clearance (according Schwartz) and S-cystatin C was (r2 = 0.76, P &lt; 0.005) in group B and (r2 = 0.75, P &lt; 0.005) in group C. CONCLUSION: There is a significant correlation between S-cystatin C and creatinine levels in both groups: in group before kidney transplantation and in patients hospitalized at intensive care reanimation unit.	Creatinine	52-62	cystatin C	Homo sapiens	100-110
11347202-12	2001	Negative correlation coefficient between calculated creatinine clearance (according Schwartz) and S-cystatin C was (r2 = 0.76, P &lt; 0.005) in group B and (r2 = 0.75, P &lt; 0.005) in group C. CONCLUSION: There is a significant correlation between S-cystatin C and creatinine levels in both groups: in group before kidney transplantation and in patients hospitalized at intensive care reanimation unit.	Creatinine	52-62	cystatin C	Homo sapiens	251-261
11174469-17	2001	A correlation (r = 0.83, P &lt;.001) was found be-tween the differences in MTAC creatinine between the first and last SPA during glucose-based PD and the difference in LVEGF between these observations.	Creatinine	80-90	surfactant protein A1	Homo sapiens	118-121
11246540-9	2001	In contrast, TFPI antigen levels were increased in the urine of these patients when compared to the levels found in the urine of the healthy control children (mean of 12.96 +/- 5.392 ng/mmol creatinine; Control, 0.239 +/- 0.191 ng/mmol creatinine; p &lt;0.035).	Creatinine	191-201	tissue factor pathway inhibitor	Homo sapiens	13-17
11246540-9	2001	In contrast, TFPI antigen levels were increased in the urine of these patients when compared to the levels found in the urine of the healthy control children (mean of 12.96 +/- 5.392 ng/mmol creatinine; Control, 0.239 +/- 0.191 ng/mmol creatinine; p &lt;0.035).	Creatinine	236-246	tissue factor pathway inhibitor	Homo sapiens	13-17
11427458-7	2001	General linear regression modeling with stepwise analysis of covariance showed that both cystatin C (partial R = 0.554; P &lt;0.001) and creatinine (partial R = 0.535; P &lt;0.001) were independent predictors of fasting tHcy, but of the two, only cystatin C (partial R = 0.242; P = 0.035) was an independent predictor of increased PML tHcy.	Creatinine	137-147	cystatin C	Homo sapiens	247-257
21383633-8	2011	In mice, CsA caused tubular injury characterized by loss of tubular epithelial cell brush border membranes, tubular collapse, cellular necrosis, interstitial fibrosis, increased production of TGF-beta1, and elevated serum creatinine (3.39 +- 0.21 vs 0.13 +- 0.02 mg/dL in controls, P &lt; 0.01).	Creatinine	222-232	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	9-12
21757984-0	2011	Serum cystatin C level is a useful marker for the evaluation of renal function in patients with cirrhotic ascites and normal serum creatinine levels.	Creatinine	131-141	cystatin C	Homo sapiens	6-16
21757984-2	2011	This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and normal Cr level.	Creatinine	101-103	cystatin C	Homo sapiens	50-54
21764700-3	2011	RESULTS: In patients with chronic kidney disease (CKD) stages 1-3, the eGFR calculated suing serum creatinine (SCr)-based equation was better correlated to GFR estimated by (99m)Tc-DTPA renal imaging than that derived from cystatin C (Cys C)-based equations, whereas in patients with CKD stages 4 and 5, the estimates by the latter equation showed a better correlation to GFR.	Creatinine	99-109	cystatin C	Homo sapiens	223-233
21056944-1	2011	BACKGROUND: The Modification of Diet in Renal Disease (MDRD) equation is widely used for the estimation of glomerular filtration rate (GFR) from plasma creatinine.	Creatinine	152-162	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	135-138
11134264-11	2001	At 3 mo, serum creatinine was significantly lower among TPMT inductors when compared with non-TPMT inductors (123.1 +/- 7.6 and 161.4 +/- 13.9 micromol/L, respectively; P = 0.01).	Creatinine	15-25	thiopurine S-methyltransferase	Homo sapiens	56-60
15635861-4	2001	RESULTS: Significant correlation between serum CyC and creatinine before HD-I and before/after HD-II was found (p &lt; 0.001).	Creatinine	55-65	cystatin C	Homo sapiens	47-50
15635861-8	2001	CONCLUSION: There was close correlation between serum CyC and creatinine before haemodialyses.	Creatinine	62-72	cystatin C	Homo sapiens	54-57
15635862-4	2001	Between cystatin C and glomerular filtration assessed by creatinine clearance was a close correlation, R = -0.787 according to Pearson.	Creatinine	57-67	cystatin C	Homo sapiens	8-18
10958875-6	2000	Cystatin C exhibited a by far better correlation with creatinine clearance than plasma creatinine.	Creatinine	54-64	cystatin C	Homo sapiens	0-10
11129064-10	2000	Serum cystatin C showed significant correlation with serum creatinine (rs = 0.45, p = 0.002), but not with creatinine clearance (rs = 0.23, p = 0.17) in patients with DN.	Creatinine	59-69	cystatin C	Homo sapiens	6-16
11129064-11	2000	Four of nine patients with creatinine clearance between 50 and 80 mL/min had increased (&gt; or = 1.4 mg/L) serum cystatin C compared with only two patients with increased serum creatinine concentration.	Creatinine	27-37	cystatin C	Homo sapiens	114-124
11016794-9	2000	(c) In the Japanese sample, multiple linear regression analyses (using a stepwise procedure) showed that SBP had a significant positive association with BMI and sodium excretion, and a significant negative association with magnesium excretion, while DBP had a significant positive association with BMI and a significant negative association with the 3MH to creatinine ratio (3MH/Cre).	Creatinine	357-367	selenium binding protein 1	Homo sapiens	105-108
10992754-8	2000	(3) There were significant correlations between BNP level and systolic blood pressure and creatinine level.	Creatinine	90-100	natriuretic peptide B	Homo sapiens	48-51
21056944-3	2011	Plasma creatinine is determined by GFR and muscle mass.	Creatinine	7-17	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	35-38
21056944-13	2011	CONCLUSIONS: These data imply that estimation of GFR by equations using plasma creatinine in the denominator cannot be used for this purpose in patients with ESRD because the effect of GFR on plasma creatinine is overruled by that of muscle mass.	Creatinine	79-89	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	49-52
21056944-13	2011	CONCLUSIONS: These data imply that estimation of GFR by equations using plasma creatinine in the denominator cannot be used for this purpose in patients with ESRD because the effect of GFR on plasma creatinine is overruled by that of muscle mass.	Creatinine	199-209	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	185-188
21789445-6	2011	Although serum cystatin C determination is increasingly being used in clinical practice worldwide, its limitations as well as the conditions its use is in fact indicated are not adequately established; on the other hand serum creatinine (and creatinine clearance) is an easily available and low cost laboratory marker with well-known limitations that can be used routinely in the assessment of renal function.	Creatinine	226-236	cystatin C	Homo sapiens	15-25
10836367-12	2000	CONCLUSIONS: Conversion from azathioprine to MMF with consecutive reduction of CsA in heart transplant recipients with CsA-impaired renal function improves renal function as evidenced by lower serum creatinine, urea nitrogen, uric acid, and higher creatinine clearance.	Creatinine	199-209	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	79-82
10836367-12	2000	CONCLUSIONS: Conversion from azathioprine to MMF with consecutive reduction of CsA in heart transplant recipients with CsA-impaired renal function improves renal function as evidenced by lower serum creatinine, urea nitrogen, uric acid, and higher creatinine clearance.	Creatinine	248-258	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	79-82
10798748-9	2000	Multivariate analysis showed that the factors predicting success of mCsA were: donor age &lt;40 years (P = 0.001), serum creatinine at mCsA initiation &lt;125 micromol/L (P = 0.02), no rejection episode before mCsA initiation (P = 0.005), and glomerulopathy as the primary renal disease (P = 0.001).	Creatinine	121-131	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	68-72
10798748-9	2000	Multivariate analysis showed that the factors predicting success of mCsA were: donor age &lt;40 years (P = 0.001), serum creatinine at mCsA initiation &lt;125 micromol/L (P = 0.02), no rejection episode before mCsA initiation (P = 0.005), and glomerulopathy as the primary renal disease (P = 0.001).	Creatinine	121-131	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	135-139
10798748-9	2000	Multivariate analysis showed that the factors predicting success of mCsA were: donor age &lt;40 years (P = 0.001), serum creatinine at mCsA initiation &lt;125 micromol/L (P = 0.02), no rejection episode before mCsA initiation (P = 0.005), and glomerulopathy as the primary renal disease (P = 0.001).	Creatinine	121-131	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	135-139
10798775-8	2000	Type 1 angiotensin II receptor mRNA expression significantly correlated with glomerular filtration rate or creatinine clearance (P = 0.034) and inversely correlated with Th1 cytokines, inducible nitric oxide synthase, and cyclooxygenase-1 mRNA expression (P&lt; or =0.013 for each).	Creatinine	107-117	angiotensin II receptor type 1	Homo sapiens	0-30
10842915-7	2000	Urinary activity of NAG was measured in the second morning urine sample by colorimetric method and the results were expressed as NAG/creatinine ratio (U/mmol).	Creatinine	133-143	O-GlcNAcase	Homo sapiens	20-23
10842915-9	2000	In women with preeclampsia, the urinary NAG/creatinine ratio was significantly higher when compared to the normal pregnant women in third trimester (1.46 +/- 1.63 U/mmol).	Creatinine	44-54	O-GlcNAcase	Homo sapiens	40-43
10850536-7	2000	Multiple regression analysis showed numerous echocardiographic and hemodynamic parameters including those of systolic and diastolic function in addition to left ventricular wall thickness, blood pressure and serum creatinine levels to be significantly associated with raised BNP levels.	Creatinine	214-224	natriuretic peptide B	Homo sapiens	275-278
10708103-7	2000	The number of days needed to reach a serum creatinine 50% below that before transplantation (T1/2(SCr)), was correlated with cold ischemia time (CIT) (P&lt;0.001) and body weight gain (BWG) (P&lt;0.01) and was inversely correlated with urinary output in the first 24 hr (P&lt;0.001), fluid load (P&lt;0.001), and central venous pressure (P&lt;0.001).	Creatinine	43-53	interleukin 1 receptor like 1	Homo sapiens	93-102
10657375-0	2000	Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy.	Creatinine	33-43	cystatin C	Homo sapiens	63-73
10634410-4	2000	SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum.	Creatinine	48-58	secretogranin II	Homo sapiens	0-2
10634410-4	2000	SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum.	Creatinine	48-58	secretogranin II	Homo sapiens	122-124
10620194-13	2000	RESULTS: Protective effects of CCR2 knockout on the urinary protein/creatinine ratio were observed on day 1, as values for this parameter were significantly lower (35 +/- 3.6) than in nephritic wild-type mice (50 +/- 6.8).	Creatinine	68-78	chemokine (C-C motif) receptor 2	Mus musculus	31-35
10655728-4	1999	The serum cystatin-C level inversely correlated more closely with creatinine clearance (Ccr) (r = -0.90) than serum beta 2-microglobulin (r = -0.85), alpha 1-microglobulin (r = -0.74) and Scr (r = -0.78).	Creatinine	66-76	cystatin C	Homo sapiens	10-20
10452282-3	1999	This study was performed to determine whether elevated levels of excreted creatinine influence the determination of the enzyme N-acetyl-beta-D-glucosaminidase (NAG).	Creatinine	74-84	O-GlcNAcase	Homo sapiens	127-158
10452282-3	1999	This study was performed to determine whether elevated levels of excreted creatinine influence the determination of the enzyme N-acetyl-beta-D-glucosaminidase (NAG).	Creatinine	74-84	O-GlcNAcase	Homo sapiens	160-163
10452282-5	1999	NAG was then measured in single-spot urines (as NAG/mmol creatinine) and in collection urines of 30 diabetic children within the same 24-h period and compared with the reference population.	Creatinine	57-67	O-GlcNAcase	Homo sapiens	0-3
10416609-7	1999	A significant (P &lt; 0.002) increase in urinary NAG after treatment was documented only in cisplatin-treated group 2 [day 2 (mean+/-SE), 93+/-2.1 units/gram creatinine; day 4, 70.6+/-16 units/gram creatinine; normalization at day 8].	Creatinine	158-168	O-GlcNAcase	Rattus norvegicus	49-52
10416609-7	1999	A significant (P &lt; 0.002) increase in urinary NAG after treatment was documented only in cisplatin-treated group 2 [day 2 (mean+/-SE), 93+/-2.1 units/gram creatinine; day 4, 70.6+/-16 units/gram creatinine; normalization at day 8].	Creatinine	198-208	O-GlcNAcase	Rattus norvegicus	49-52
10406826-13	1999	Sodium excretion rose (P&lt;0.05), and creatinine clearance was sustained during both BNP and combined infusions.	Creatinine	39-49	natriuretic peptide B	Homo sapiens	86-89
21401897-9	2011	Linear correlation analysis demonstrated significant correlations between TLR-3 level and disease severity markers (total bilirubin, prothrombin activity, creatinine, white blood cell count, and maximum volume of ascitic fluid) in individual CSHB patients.	Creatinine	155-165	toll like receptor 3	Homo sapiens	74-79
21198422-1	2011	BACKGROUND: The plasma level of cystatin C is a better marker than plasma creatinine for successful aging.	Creatinine	74-84	cystatin C	Homo sapiens	32-42
10389935-7	1999	Average urine C-PTHrP:urine creatinine ratio was 7.56 +/- 5.17 x 10(-1) pmol/mg creatinine in 28 lung cancer patients, whereas it was 4.91 +/- 1.77 in 10 normal subjects; the difference was statistically significant (P = 0.0287).	Creatinine	80-90	parathyroid hormone like hormone	Homo sapiens	16-21
21486585-6	2011	RESULTS: Receiver-operator characteristics curves showed a similar efficiency to detect a creatinine clearance &lt;60 mL/min per 1.73m(2) (Cys = 0.753; creatinine [Cr] = 0.799; glomerular filtration rate [GFR, Cockcroft-Gault formula] = 0.842; urea = 0.823; P = .001).	Creatinine	90-100	cystatin C	Homo sapiens	139-142
21303657-11	2011	hK1 specific amidase activity was expressed as muM/(minmg creatinine) to correct for differences in urine flow rate.	Creatinine	58-68	keratin 1	Homo sapiens	0-3
21947986-1	2011	BACKGROUND: Although plasma pigment epithelium-derived factor (PEDF) levels have been shown to be significantly correlated with the levels of creatinine (Cr) in type 2 diabetes, little is known about the association between PEDF levels and renal dysfunction in patients with coronary artery disease (CAD).	Creatinine	142-152	serpin family F member 1	Homo sapiens	28-61
21947986-1	2011	BACKGROUND: Although plasma pigment epithelium-derived factor (PEDF) levels have been shown to be significantly correlated with the levels of creatinine (Cr) in type 2 diabetes, little is known about the association between PEDF levels and renal dysfunction in patients with coronary artery disease (CAD).	Creatinine	142-152	serpin family F member 1	Homo sapiens	63-67
21947986-1	2011	BACKGROUND: Although plasma pigment epithelium-derived factor (PEDF) levels have been shown to be significantly correlated with the levels of creatinine (Cr) in type 2 diabetes, little is known about the association between PEDF levels and renal dysfunction in patients with coronary artery disease (CAD).	Creatinine	154-156	serpin family F member 1	Homo sapiens	28-61
21947986-1	2011	BACKGROUND: Although plasma pigment epithelium-derived factor (PEDF) levels have been shown to be significantly correlated with the levels of creatinine (Cr) in type 2 diabetes, little is known about the association between PEDF levels and renal dysfunction in patients with coronary artery disease (CAD).	Creatinine	154-156	serpin family F member 1	Homo sapiens	63-67
21947986-3	2011	RESULTS: Plasma PEDF levels were positively correlated with serum Cr (p ( 0.0001) and UA (p ( 0.0001) and negatively correlated with the estimated glomerular filtration rate (eGFR) (p ( 0.0001), whereas there was no association between plasma PEDF and age or hsCRP.	Creatinine	66-68	serpin family F member 1	Homo sapiens	16-20
20829419-7	2011	RESULTS: Serum CysC correlated modestly with O"Leary modified Jaffe, compensated kinetic Jaffe, enzymatic creatinine, and standard kinetic Jaffe 0.72/0.71/0.72/0.72 (all P &lt; 0.001).	Creatinine	106-116	cystatin C	Homo sapiens	15-19
21124314-4	2011	The pharmacokinetic model involving the inhibition of hOCT2 (model 1), hOCT2, and MATE1 or MATE2-K (model 2) could predict the elevation in serum creatinine levels in individual subjects receiving DX-619.	Creatinine	146-156	solute carrier family 47 member 2	Homo sapiens	91-98
21769262-5	2011	We here report that two Japanese patients who had BBS with normal BUN and creatinine levels had elevated levels of cystatin C, a sensitive marker of glomerular filtration rate.	Creatinine	74-84	cystatin C	Homo sapiens	115-125
22032777-5	2011	The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels.	Creatinine	58-68	natriuretic peptide B	Homo sapiens	23-26
22032777-5	2011	The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels.	Creatinine	157-167	natriuretic peptide B	Homo sapiens	23-26
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	hepatocyte growth factor	Homo sapiens	85-88
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	hepatocyte growth factor	Homo sapiens	218-221
21164029-7	2011	In conclusion, among adults diagnosed with CKD using the creatinine-based CKD-EPI equation, the adverse prognosis is limited to the subset who also have CKD according to the cystatin C-based equation.	Creatinine	57-67	cystatin C	Homo sapiens	174-184
21461013-11	2011	Sensitivity of the microalbumin/creatinine ratio to detect VUR was 62.5% (specificity 75%).	Creatinine	32-42	VUR	Homo sapiens	59-62
20813096-5	2010	Three days after the administration of cisplatin, plasma creatinine and blood urea nitrogen (BUN) levels were increased in both Mate1(+/+) and Mate1(-/-) mice compared with vehicle-treated controls, and creatinine clearance was decreased.	Creatinine	57-67	solute carrier family 47, member 1	Mus musculus	128-133
20813096-5	2010	Three days after the administration of cisplatin, plasma creatinine and blood urea nitrogen (BUN) levels were increased in both Mate1(+/+) and Mate1(-/-) mice compared with vehicle-treated controls, and creatinine clearance was decreased.	Creatinine	57-67	solute carrier family 47, member 1	Mus musculus	143-148
20813096-6	2010	Moreover, a significant rise in creatinine and BUN levels was observed in cisplatin-treated Mate1(-/-) mice in comparison to Mate1(+/+) mice.	Creatinine	32-42	solute carrier family 47, member 1	Mus musculus	92-97
20870574-6	2010	Importantly, cystatin C appears to be a useful marker or identifying individuals at a higher risk of cardiovascular events among patients belonging ot a relatively lox-risk category as assessed by both creatinine and estimated glomerular filtration rate values.	Creatinine	202-212	cystatin C	Homo sapiens	13-23
20624851-1	2010	BACKGROUND: Cystatin C is a low molecular weight cysteine proteinase inhibitor whose plasma or serum concentrations have been shown to be better correlated with glomerular filtration rate than serum creatinine concentrations.	Creatinine	199-209	cystatin C	Homo sapiens	12-22
20447660-8	2010	Multivariate analysis yielded cystatin C measured at the study start as a superior prognostic parameter for all time points (area under the receiver operating characteristic 12 months: 0.963; 24 months: 0.910; 48 months: 0.949) compared with the conventionally used creatinine levels.	Creatinine	266-276	cystatin C	Homo sapiens	30-40
20924213-7	2010	Both serum creatinine and cystatin C were predictive factors for acute kidney injury in univariate analysis, with a diagnostic accuracy of 0.735 (95% confidence interval (CI), 0.525-0.945; p=0.028) for serum cystatin C and 0.698 (95% CI, 0.495-0.901, p=0.063) for creatinine.	Creatinine	11-21	cystatin C	Homo sapiens	208-218
10482042-2	1999	Diabetes mellitus and associated histopathological changes, which developed spontaneously by 30-46 weeks after birth of OLETF rats, were accompanied by approximately 65% increase in glomerular cPLA2 activity that showed significant correlations with elevated plasma glucose levels and creatinine clearance.	Creatinine	285-295	phospholipase A2 group IVA	Rattus norvegicus	193-198
10406511-8	1999	Similarly, TM increased for patients with creatinine clearances (CrC) &lt; 5 mL/min.	Creatinine	42-52	thrombomodulin	Homo sapiens	11-13
10406513-9	1999	Correlation coefficients (Spearman"s rho) between change of serum leptin and change of BMI, of serum insulin, of glomerular filtration rate (average of urine creatinine clearance and urine urea clearance) were 0.267 (p &gt; 0.05, n = 20), 0.441 (p &gt; 0.05, n = 16), 0.706 (p &gt; 0.05, n = 8) respectively.	Creatinine	158-168	leptin	Homo sapiens	66-72
20023602-12	2010	NR1 attenuated I/R-induced renal dysfunction as indicated by the level of serum creatinine and histological evaluation.	Creatinine	80-90	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	0-3
20807409-13	2010	However, a significant down-regulation of AT2R protein expression was observed in low-protein fed animals alongside a decrease in creatinine clearance.	Creatinine	130-140	angiotensin II receptor, type 2	Rattus norvegicus	42-46
20522534-4	2010	Plasma CysC levels were related to the development of AKI as defined by an increase in serum creatinine of &gt;or=50% or &gt;or=0.3 mg/dl from baseline up to 3 days postoperative.	Creatinine	93-103	cystatin C	Homo sapiens	7-11
20131076-14	2010	Moreover, a significant positive correlation was observed between the number of interstitial MCs, the expression of SCF, PAR-2 and alpha-SMA and the serum creatinine level (r = 0.738 for MCs, r = 0.658 for alpha-SMA, r = 0.692 for PAR-2, r = 0.754 for SCF, P &lt; 0.05).	Creatinine	155-165	F2R like trypsin receptor 1	Homo sapiens	121-126
9892367-2	1998	The recommended weekly Kt/V for urea is 2.0, with the corresponding creatinine clearance (CrCl) of 60 L/1.73 m2.	Creatinine	68-78	CRCL	Homo sapiens	90-94
20131076-14	2010	Moreover, a significant positive correlation was observed between the number of interstitial MCs, the expression of SCF, PAR-2 and alpha-SMA and the serum creatinine level (r = 0.738 for MCs, r = 0.658 for alpha-SMA, r = 0.692 for PAR-2, r = 0.754 for SCF, P &lt; 0.05).	Creatinine	155-165	F2R like trypsin receptor 1	Homo sapiens	231-236
20493420-9	2010	RESULTS: The highest quartile of cystatin C distribution showed an older age and worsel parameters of renal function (cystatin C, serum creatinine and GFR) than the other groups.	Creatinine	136-146	cystatin C	Homo sapiens	33-43
21120190-7	2010	Soluble syndecan-1 levels correlated with disease stage, percentage of plasma cells in the bone marrow, beta(2) microglobulin level, serum M-component concentration, and creatinine level.	Creatinine	170-180	syndecan 1	Homo sapiens	8-18
21537427-8	2010	Cystatin-C (Cys C) may in future be the preferred marker of diabetic nephropathy due differences in measurements of serum creatinine by various methods.	Creatinine	122-132	cystatin C	Homo sapiens	0-10
21537427-8	2010	Cystatin-C (Cys C) may in future be the preferred marker of diabetic nephropathy due differences in measurements of serum creatinine by various methods.	Creatinine	122-132	cystatin C	Homo sapiens	12-17
20004949-10	2010	The number of CXCR3-positive cells in kidneys with Alport syndrome correlated with serum creatinine (P &lt; .05) and with morphologic features of a progressive disease (eg, interstitial fibrosis, glomerulosclerosis, and tubular atrophy).	Creatinine	89-99	C-X-C motif chemokine receptor 3	Homo sapiens	14-19
19895657-5	2010	Multivariable predictors of OPG values at presentation included haemoglobin (T = -2.82; P = 0.005), creatinine (T = 4.56; P &lt; 0.001), age (T = 9.66; P &lt; 0.001), active smoking (T = 2.25; P = 0.025) and pulse rate (T = 3.23; P = 0.001).	Creatinine	100-110	TNF receptor superfamily member 11b	Homo sapiens	28-31
9821699-5	1998	RESULTS: The levels of urinary B2M and B2M/creatinine ratio were highest in the 1-month-old group, followed by a decrease during the first 3 months.	Creatinine	43-53	beta-2-microglobulin	Homo sapiens	39-42
9830275-6	1998	Serum creatinine concentration was positively correlated with the 24-hour urinary excretion of beta 2M in patients with GN or CRF (r = 0.50, p &lt; 0.001).	Creatinine	6-16	beta-2-microglobulin	Homo sapiens	95-102
9761499-8	1998	Notably, creatinine clearance significantly decreased in CON (-53+/-8% 8 vs basal) and EPO (-38+/-8% vs basal), while it did not change in PHL rats.	Creatinine	9-19	erythropoietin	Rattus norvegicus	87-90
9657343-10	1998	Serum creatinine values were related to MYO test results.	Creatinine	6-16	myoglobin	Homo sapiens	40-43
20395925-2	2010	The aim of this study was to investigate the possible causal association of PIH with maternal serum PAPP-A and urinary protein-creatinine ratio (UPCr) as well as to evaluate the usefulness of these two variables as predictive markers of PIH.	Creatinine	127-137	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	76-79
19961288-7	2010	We found a trend towards an association of YKL-40 levels with urinary albumin/creatinine ratio (UACR) (beta = 0.12, p = 0.08).	Creatinine	78-88	chitinase 3 like 1	Homo sapiens	43-49
20222955-0	2010	A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.	Creatinine	127-137	synaptotagmin 1	Homo sapiens	99-103
9610957-1	1997	Plasma von Willebrand factor antigen, soluble thrombomodulin, and tissue factor were increased in 31 patients with severe chronic renal failure (creatinine clearance &lt;20 ml/min) under conservative treatment, whereas plasminogen activator inhibitor antigen did not differ significantly from healthy controls.	Creatinine	145-155	coagulation factor III, tissue factor	Homo sapiens	0-79
9430873-7	1997	Thus, urinary IL-6/EGF ratio was markedly increased in the former group (&gt; 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P &lt; 0.0001), and was only slightly increased in the latter group (&lt; 3-fold).	Creatinine	145-155	epidermal growth factor	Homo sapiens	19-22
9605246-7	1997	TM levels correlated positively with serum creatinine (r=0.46, p=0.002), proteinuria (r=0.48, p=0.007), and duration of diabetes (r=0.41, p=0.042).	Creatinine	43-53	thrombomodulin	Homo sapiens	0-2
9334654-4	1997	RESULTS: Urine HB-EGF levels were specifically and significantly decreased in IC patients as compared to asymptomatic controls or patients with bacterial cystitis, whether expressed as concentration (amount per volume of urine) or the amount relative to urine creatinine in each specimen.	Creatinine	260-270	heparin binding EGF like growth factor	Homo sapiens	15-21
9334654-6	1997	Further, the amounts of urine EGF and IGF1 were also elevated in IC patients as compared to patients with bacterial cystitis, and urine IGFBP3 levels were significantly elevated when expressed per milligram of urine creatinine.	Creatinine	216-226	insulin like growth factor binding protein 3	Homo sapiens	136-142
9350894-10	1997	By univariate analyses for all neonates, there were significant relations between plasma thrombomodulin concentration and gestational age, birthweight, plasma pH, creatinine concentration, platelet count and antithrombin III activity.	Creatinine	163-173	thrombomodulin	Homo sapiens	89-103
20015945-4	2010	The dialysate-to-plasma ratio for creatinine (D/P Cr) was positively correlated to dialysate CTGF concentration and estimated local peritoneal production of CTGF.	Creatinine	34-44	cellular communication network factor 2	Homo sapiens	93-97
20015945-4	2010	The dialysate-to-plasma ratio for creatinine (D/P Cr) was positively correlated to dialysate CTGF concentration and estimated local peritoneal production of CTGF.	Creatinine	34-44	cellular communication network factor 2	Homo sapiens	157-161
20199369-9	2010	Direct correlations were found between hepatocyte growth factor levels and ferric reducing activity of plasma as well as hepatocyte growth factor and creatinine or uric acid.	Creatinine	150-160	hepatocyte growth factor	Homo sapiens	121-145
9397135-3	1997	Excretion of EGF was studied in 6 patients with APKD (median age 42 years; serum creatinine [median] 95 [range-80-133] mumol/l) and compared with that of 28 healthy controls.	Creatinine	81-91	epidermal growth factor	Homo sapiens	13-16
9397135-4	1997	EGF was determined in a spot morning urine by using a specific radioimmunoassay, and expressed in relation to creatinine excretion.	Creatinine	110-120	epidermal growth factor	Homo sapiens	0-3
9447482-6	1997	ACE inhibitor treatment of affected dogs significantly delayed (P &lt; 0.05) the onset of an increase in serum creatinine concentration, tended to delay the decline of glomerular filtration rate and effective renal plasma flow (ERPF), significantly improved (P &lt; 0.05) the ERPF at 110-154 days of age, and significantly slowed (P &lt; 0.01) the rate of increase of proteinuria.	Creatinine	111-121	angiotensin I converting enzyme	Canis lupus familiaris	0-3
9301426-12	1997	Leptin correlated modestly with serum creatinine in non-dialysis subjects.	Creatinine	38-48	leptin	Homo sapiens	0-6
9222647-5	1997	Multiple regression analyses indicated that percent body fat, waist to hip ratio, plasma insulin, gender and renal function (1/creatinine), but not insulin sensitivity, were significant and independent determinants of plasma leptin level.	Creatinine	127-137	leptin	Homo sapiens	225-231
9146653-8	1997	Urinary epidermal growth factor significantly correlated with serum creatinine (R = -0.702, p &lt; 0.0001), urinary alpha 1-microglobulin (R = -0.606, p &lt; 0.0001), urinary microalbumin (R = -0.708, p &lt; 0.0001) and total DMSA uptake (R = 0.744, p &lt; 0.0001).	Creatinine	68-78	epidermal growth factor	Homo sapiens	8-31
20113272-7	2010	There was a significant positive correlation between creatinine and cystatin C serum levels before and after exposure to radiocontrast medium (p &lt; 0.05) in all patients, including subgroup analyses.	Creatinine	53-63	cystatin C	Homo sapiens	68-78
19420105-3	2009	METHODS: The Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgAN (PREDICT-IgAN) was a multicentre retrospective observational study to investigate associations between progression of IgAN (a 50% increase of serum creatinine level and slope of eGFR) and a hundred atherosclerotic disease-related gene polymorphisms, mainly single nucleotide polymorphisms (SNPs) in 320 IgAN patients who had more than a normal range of urinary protein (&gt; or =0.25 g/day) at diagnosis.	Creatinine	250-260	IGAN1	Homo sapiens	97-101
9060825-5	1997	Anti-TF antibody significantly reduced glomerular fibrin deposition (fibrin scores, 0.43 +/- 0.10 (treated) and 1.40 +/- 0.19 (control); P &lt; 0.0005), crescent formation (0.33 +/- 0.05 (treated) and 1.0 +/- 0.06 (control); P &lt; 0.0005), and development of renal failure (serum creatinine, 168 +/- 22 mumol/l (treated) and 267 +/- 35 mumol/l (control); P &lt; 0.04).	Creatinine	281-291	coagulation factor III, tissue factor	Homo sapiens	5-7
19420105-3	2009	METHODS: The Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgAN (PREDICT-IgAN) was a multicentre retrospective observational study to investigate associations between progression of IgAN (a 50% increase of serum creatinine level and slope of eGFR) and a hundred atherosclerotic disease-related gene polymorphisms, mainly single nucleotide polymorphisms (SNPs) in 320 IgAN patients who had more than a normal range of urinary protein (&gt; or =0.25 g/day) at diagnosis.	Creatinine	250-260	IGAN1	Homo sapiens	103-115
19420105-3	2009	METHODS: The Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgAN (PREDICT-IgAN) was a multicentre retrospective observational study to investigate associations between progression of IgAN (a 50% increase of serum creatinine level and slope of eGFR) and a hundred atherosclerotic disease-related gene polymorphisms, mainly single nucleotide polymorphisms (SNPs) in 320 IgAN patients who had more than a normal range of urinary protein (&gt; or =0.25 g/day) at diagnosis.	Creatinine	250-260	IGAN1	Homo sapiens	111-115
19420105-3	2009	METHODS: The Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgAN (PREDICT-IgAN) was a multicentre retrospective observational study to investigate associations between progression of IgAN (a 50% increase of serum creatinine level and slope of eGFR) and a hundred atherosclerotic disease-related gene polymorphisms, mainly single nucleotide polymorphisms (SNPs) in 320 IgAN patients who had more than a normal range of urinary protein (&gt; or =0.25 g/day) at diagnosis.	Creatinine	250-260	IGAN1	Homo sapiens	111-115
19715672-4	2009	MafA(-/-)MafK(+) mice developed severe overt diabetes mellitus within 5weeks old, and showed higher levels of proteinuria and serum creatinine.	Creatinine	132-142	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	0-4
19816874-9	2009	Compared to those with low BNP (n = 74), those of high BNP (n = 41) were older, had lower LVEF, higher creatinine levels, suffered more deaths, and HF hospitalizations.	Creatinine	103-113	natriuretic peptide B	Homo sapiens	55-58
19938052-9	2009	Cystatin C was positively and significantly correlated with age, hs-CRP, white blood cells (WBC), creatinine, and UA (r &gt; 0, P &lt; 0.05), whereas a significantly negative correlation was observed with HDL-C (r = - 0.227, P &lt; 0.05).	Creatinine	98-108	cystatin C	Homo sapiens	0-10
19725889-0	2009	Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels.	Creatinine	103-113	cystatin C	Homo sapiens	6-16
19725889-15	2009	CONCLUSION: Serum CysC level is a good marker for predicting HRS and survival in patients with cirrhotic ascites and a normal Cr level.	Creatinine	126-128	cystatin C	Homo sapiens	18-22
19695216-3	2009	After (24h) induction of ischemia, xCT(-/-) mice had elevated concentrations of blood urea nitrogen and creatinine indicative of ARF, while in xCT(+/-) and xCT(+/+) mice, these parameters did not differ from the sham-operated mice.	Creatinine	104-114	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	35-38
9098510-8	1997	Urinary EGF (corrected for the urine creatinine concentration and measured as ng per mg creatinine) was highest in the two youngest groups, 78.5 +/- 14.3 and 76.2 +/- 18.8 (mean +/- standard error of the mean), respectively, and decreased with age so that the lowest urinary EGF was observed in the oldest group (27.0 +/- 8.8 ng per mg creatinine).	Creatinine	37-47	epidermal growth factor	Homo sapiens	8-11
9098510-8	1997	Urinary EGF (corrected for the urine creatinine concentration and measured as ng per mg creatinine) was highest in the two youngest groups, 78.5 +/- 14.3 and 76.2 +/- 18.8 (mean +/- standard error of the mean), respectively, and decreased with age so that the lowest urinary EGF was observed in the oldest group (27.0 +/- 8.8 ng per mg creatinine).	Creatinine	88-98	epidermal growth factor	Homo sapiens	8-11
9098510-8	1997	Urinary EGF (corrected for the urine creatinine concentration and measured as ng per mg creatinine) was highest in the two youngest groups, 78.5 +/- 14.3 and 76.2 +/- 18.8 (mean +/- standard error of the mean), respectively, and decreased with age so that the lowest urinary EGF was observed in the oldest group (27.0 +/- 8.8 ng per mg creatinine).	Creatinine	88-98	epidermal growth factor	Homo sapiens	8-11
9127740-10	1997	A relation was found between the mean plasma creatinine concentration during the first 24 hours after acute myocardial infarction and the discordance between infarct size estimated from cumulative hydroxybutyrate dehydrogenase release, compared to infarct size estimated from cumulative myoglobin or fatty acid-binding protein release.	Creatinine	45-55	myoglobin	Homo sapiens	287-296
9116433-3	1997	The plasma thrombomodulin-to-serum creatinine ratio was also significantly elevated (0.62 vs 0.48 microgram/mumol, p = 0.0005).	Creatinine	35-45	thrombomodulin	Homo sapiens	11-25
9116433-5	1997	Stepwise regression analysis showed the serum D-dimer concentration, plasma pH and serum creatinine concentration were significant independent variables for plasma thrombomodulin concentration, whereas base deficit, platelet count, fibrinogen concentrations and antithrombin III activity were not.	Creatinine	89-99	thrombomodulin	Homo sapiens	164-178
19660612-4	2009	NT-pro-BNP levels (median 373 pg/ml, interquartile range 150 to 997) were associated with age, gender, creatinine, New York Heart Association (NYHA) functional class, atrial fibrillation, left ventricular (LV) end-systolic dimension, and the LV ejection fraction.	Creatinine	103-113	natriuretic peptide B	Homo sapiens	7-10
19667968-7	2009	However, high frequencies of not only CD127(high) but also CD127(low) showed a significant correlation with serum creatinine levels (P=0.012 and P=0.003, respectively).	Creatinine	114-124	interleukin 7 receptor	Homo sapiens	38-43
19667968-7	2009	However, high frequencies of not only CD127(high) but also CD127(low) showed a significant correlation with serum creatinine levels (P=0.012 and P=0.003, respectively).	Creatinine	114-124	interleukin 7 receptor	Homo sapiens	59-64
19616673-10	2009	The association between cystatin C and the combined end point of death or rehospitalization during 1-year follow-up remained significant after adjusting for age, race, gender, co-morbidities, and creatinine.	Creatinine	196-206	cystatin C	Homo sapiens	24-34
19295502-6	2009	Elevated serum cystatin C may identify patients with "preclinical" kidney disease not detected by traditional serum creatinine measurements.	Creatinine	116-126	cystatin C	Homo sapiens	15-25
9093774-4	1997	The TM levels were significantly higher in SLE patients with the following abnormalities in their past history or present illness: persistent proteinuria, cellular casts, positive anti-dsDNA antibodies (p &lt; 0.001), hypoalbuminemia, decreased creatinine clearance (Ccr), positive anti-Sm antibody, positive immune complex, leukopenia (p &lt; 0.01), pericarditis, oral ulcer, fluorescent anti-nuclear antibody (FANA), decreased C3 and arthralgia (p &lt; 0.05).	Creatinine	245-255	thrombomodulin	Homo sapiens	4-6
9093774-5	1997	The serum TM levels in SLE showed a direct correlation with the urinary protein level (p &lt; 0.01) and serum creatinine level (p &lt; 0.01), and an inverse correlation with the serum albumin level (p &lt; 0.01) and complement C3 level (p &lt; 0.05).	Creatinine	110-120	thrombomodulin	Homo sapiens	10-12
8832145-18	1996	Urinary oxalate/creatinine ratio was 705 mumol/mol and gave rise to the diagnosis of PH 1.	Creatinine	16-26	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	85-89
19357716-2	2009	We studied its possible role in angiotensin II-mediated renal injury by infusing wild-type and osteopontin knockout mice with angiotensin II and found that it raised blood pressure and increased urinary albumin/creatinine ratios in both strains of mice.	Creatinine	211-221	secreted phosphoprotein 1	Mus musculus	95-106
20011875-9	2009	CONCLUSION: The cystatin C and the Cys-GFR showed significant changes after cardiac surgery when compared with the creatinine and respective GFR calculated by the Cockcroft-Gault and MDRD formulas.	Creatinine	115-125	cystatin C	Homo sapiens	16-26
19746273-9	2009	Cystatin C had a positive correlation with serum creatinine (r =0.57 p &lt;0.001).	Creatinine	49-59	cystatin C	Homo sapiens	0-10
8741391-3	1996	We hypothesized that the soluble form of TM which reflects the damage of the endothelial cells and that simultaneously, soluble TM will be affected by renal excretion because a significant positive correlation has been found between soluble TM and serum creatinine (sCr) in the renal failure state.	Creatinine	254-264	thrombomodulin	Homo sapiens	41-43
19746273-10	2009	CONCLUSIONS: Diabetics with coronary artery disease have higher levels of cystatin C, that are closely correlated with serum creatinine levels.	Creatinine	125-135	cystatin C	Homo sapiens	74-84
19261138-8	2009	BNP levels were significantly correlated with New York Heart Association classification (P=.05), ejection fraction (P=0.0001), creatinine levels (P=0.05), and overall Minnesota Living with Heart Failure Questionnaire scores (P=.01).	Creatinine	127-137	natriuretic peptide B	Homo sapiens	0-3
8825381-2	1996	Urinary EGF excretion was expressed as a ratio of urinary EGF to urinary creatinine concentration (EGF/Cr) for random and 24-h urine, and a daily total urinary EGF for 24-h urine.	Creatinine	73-83	epidermal growth factor	Homo sapiens	8-11
8825381-5	1996	During the course of ARF, a decline in urinary EGF/Cr from the period before peak serum creatinine to the period after the declination of serum creatinine was noted (p = 0.013, n = 13, by repeated measure analysis), with a constant low daily total urine EGF (p value not significant).	Creatinine	88-98	epidermal growth factor	Homo sapiens	47-50
8825381-5	1996	During the course of ARF, a decline in urinary EGF/Cr from the period before peak serum creatinine to the period after the declination of serum creatinine was noted (p = 0.013, n = 13, by repeated measure analysis), with a constant low daily total urine EGF (p value not significant).	Creatinine	144-154	epidermal growth factor	Homo sapiens	47-50
8825381-6	1996	However, a rise in both urinary EGF/Cr and daily total urine EGF was found between the period of serum creatinine decline and the period of completely normal serum creatinine (p &lt; 0.001).	Creatinine	103-113	epidermal growth factor	Homo sapiens	32-35
8825381-6	1996	However, a rise in both urinary EGF/Cr and daily total urine EGF was found between the period of serum creatinine decline and the period of completely normal serum creatinine (p &lt; 0.001).	Creatinine	103-113	epidermal growth factor	Homo sapiens	61-64
8825381-6	1996	However, a rise in both urinary EGF/Cr and daily total urine EGF was found between the period of serum creatinine decline and the period of completely normal serum creatinine (p &lt; 0.001).	Creatinine	164-174	epidermal growth factor	Homo sapiens	61-64
8728185-11	1996	The age- and disease-adjusted survival in our center was comparable to centers that used standard four 2-L exchange regimes, despite a substantially lower mean KT/V and creatinine clearance (CrCl).	Creatinine	169-179	CRCL	Homo sapiens	191-195
8860739-4	1996	The mean urinary calbindin-D level was 2.44 + or - 0.31 (mean + or - SE) ng/mg creatinine in 40 healthy subjects.	Creatinine	79-89	calbindin 1	Homo sapiens	17-26
8860739-5	1996	Urinary calbindin-D levels were elevated (&gt;10 ng/mg creatinine) in 2 of 33 patients (6%) with benign and 1 of 50 (2%) with malignant urological diseases.	Creatinine	55-65	calbindin 1	Homo sapiens	8-17
7537489-4	1995	A transient, yet significant, increase in the postoperative creatinine level in the aprotinin group (p = 0.0006), but not in blood urea nitrogen level (p = 0.22), was noted.	Creatinine	60-70	pancreatic trypsin inhibitor	Bos taurus	84-93
7736685-5	1995	Serum creatinine was lower in patients without PA (Scr 1.0 +/- 0.4 mg/dl) than in those with PA (Scr 1.5 +/- 1.0 mg/dl), but the difference was not statistically significant.	Creatinine	6-16	ribosomal protein S4 X-linked	Homo sapiens	51-58
19237809-5	2009	Cystatin C demonstrated a significant time dependent increase of dialysate concentration and decline in the serum concentrations during PET, and a strong correlation between serum creatinine and serum cystatin C concentrations(r: 0.62, p= 0.008).	Creatinine	180-190	cystatin C	Homo sapiens	0-10
19237809-7	2009	Peritoneal mass transfer (mg/4 hr per 1.73 m 2 ) for cystatin C serum creatinine was 1.68 +/- 0.67 and 73.3 +/- 29.8, respectively.	Creatinine	70-80	cystatin C	Homo sapiens	53-63
19194162-10	2009	Pretreatment with capsazepine, CGRP(8-37), indomethacin, and denervation of primary sensory nerves significantly increased blood urea nitrogen and serum creatinine levels, renal vascular permeability, renal tissue levels of myeloperoxidase activity, cytokine-induced neutrophil chemoattractant, and tumor necrosis factor-alpha, and decreased renal tissue blood flow.	Creatinine	153-163	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
7798671-4	1995	Peak HILDA/LIF levels correlated with increased temperature and creatinine and IL-6 and with decreased arterial CO2 (P &lt; .05).	Creatinine	64-74	LIF interleukin 6 family cytokine	Homo sapiens	5-10
7798671-4	1995	Peak HILDA/LIF levels correlated with increased temperature and creatinine and IL-6 and with decreased arterial CO2 (P &lt; .05).	Creatinine	64-74	LIF interleukin 6 family cytokine	Homo sapiens	11-14
8713290-3	1995	The level of leu-enkephalin in adrenal glands was directly related to plasma creatinine.	Creatinine	77-87	proenkephalin	Rattus norvegicus	17-27
18957531-7	2009	YKL-40 levels correlated with the urinary albumin-to-creatinine ratio in the total group of participants (r2 = 0.25, P &lt; 0.001).	Creatinine	53-63	chitinase 3 like 1	Homo sapiens	0-6
18946499-7	2009	COX-2 inhibition improved the creatinine clearance in lipopolysaccharide-treated rats but not after ischemia/reperfusion-induced acute renal injury.	Creatinine	30-40	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
18701818-8	2009	Age- and serum creatinine-adjusted MMP-2 levels were significantly increased (p = 0.001) in proportion to the increasing levels of proteinuria.	Creatinine	15-25	matrix metallopeptidase 2	Homo sapiens	35-40
18983837-5	2009	RESULTS: Significant correlations are found between cystatin C and creatinine (r=0.54).	Creatinine	67-77	cystatin C	Homo sapiens	52-62
19051098-10	2009	Cystatin C is highly correlated with creatinine (r = 0.6196, p&lt;0.0001).	Creatinine	37-47	cystatin C	Homo sapiens	0-10
19731180-6	2009	In a subgroup of patients with neurological disease and muscle atrophy the cystatin C equation performed better than the expressions combining creatinine and cystatin C.	Creatinine	143-153	cystatin C	Homo sapiens	75-85
19249500-9	2009	On univariate analysis, visfatin correlated positively with prothrombin fragments 1 + 2, VCAM, creatinine, high-sensitivity C-reactive protein, and negatively with albumin.	Creatinine	95-105	nicotinamide phosphoribosyltransferase	Homo sapiens	24-32
18843253-5	2008	Ischemic injury induced in CCR2(-/-) mice or in CCR2(+/+) mice, made chimeric with CCR2(-/-) bone marrow, resulted in lower plasma creatinine levels and their kidneys had fewer infiltrated F4/80(low) macrophages compared to control mice.	Creatinine	131-141	chemokine (C-C motif) receptor 2	Mus musculus	27-31
18843253-5	2008	Ischemic injury induced in CCR2(-/-) mice or in CCR2(+/+) mice, made chimeric with CCR2(-/-) bone marrow, resulted in lower plasma creatinine levels and their kidneys had fewer infiltrated F4/80(low) macrophages compared to control mice.	Creatinine	131-141	chemokine (C-C motif) receptor 2	Mus musculus	48-52
18843253-5	2008	Ischemic injury induced in CCR2(-/-) mice or in CCR2(+/+) mice, made chimeric with CCR2(-/-) bone marrow, resulted in lower plasma creatinine levels and their kidneys had fewer infiltrated F4/80(low) macrophages compared to control mice.	Creatinine	131-141	chemokine (C-C motif) receptor 2	Mus musculus	48-52
18771467-11	2008	IgAN patients, especially those in group 2 with IgG-AECA or anti-87 kD IgG-AECA, had significantly higher serum creatinine and lower creatinine clearance than those without.	Creatinine	112-122	IGAN1	Homo sapiens	0-4
7892827-2	1994	Urinary beta 2-microglobulin is frequently used as a marker of tubular proteinuria with an arbitrarily chosen value (34 micrograms/mmole creatinine) as the cut-off limit.	Creatinine	137-147	beta-2-microglobulin	Homo sapiens	8-28
18771467-11	2008	IgAN patients, especially those in group 2 with IgG-AECA or anti-87 kD IgG-AECA, had significantly higher serum creatinine and lower creatinine clearance than those without.	Creatinine	133-143	IGAN1	Homo sapiens	0-4
19175073-0	2008	[Usefulness of the formula for predicting creatinine clearance from serum cystatin C].	Creatinine	42-52	cystatin C	Homo sapiens	74-84
19175073-5	2008	We developed the formula for predicting creatinine clearance (Ccr) from serum cystatin C, serum creatinine and serum beta 2-microgroburin by multiple regression analysis.	Creatinine	40-50	cystatin C	Homo sapiens	78-88
19175073-5	2008	We developed the formula for predicting creatinine clearance (Ccr) from serum cystatin C, serum creatinine and serum beta 2-microgroburin by multiple regression analysis.	Creatinine	40-50	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-123
19175073-10	2008	Our formula using serum cystatin C for predicting Ccr is a useful and precise marker for Ccr than other commonly used formulas using serum creatinine.	Creatinine	139-149	cystatin C	Homo sapiens	24-34
19015597-0	2008	Serum cystatin C is related to pulse wave velocity even in subjects with normal serum creatinine.	Creatinine	86-96	cystatin C	Homo sapiens	6-16
19015597-2	2008	The aim of this study is to evaluate whether serum cystatin C is related to arterial stiffness independently of serum creatinine in subjects for whom serum creatinine is normal.	Creatinine	156-166	cystatin C	Homo sapiens	51-61
19015597-10	2008	In conclusion, this study confirmed that serum cystatin C was related to pulse wave velocity even in subjects with normal serum creatinine.	Creatinine	128-138	cystatin C	Homo sapiens	47-57
18971553-3	2008	Since a decrease in renal clearance is a prevalent clinical problem in patients with hypertension, we aimed to study the renal clearance of matrix Gla-protein from the circulation in these patients having a wide range of creatinine clearances.	Creatinine	221-231	matrix Gla protein	Homo sapiens	140-158
7988015-4	1994	In a subset of 100 subjects, fasting serum creatinine values averaged 8.3 +/- 5.2 (SD) mumol/L higher when measured by the kinetic Jaffe procedure than by an enzymatic method (creatinine PAP).	Creatinine	43-53	regenerating family member 3 alpha	Homo sapiens	187-190
7534496-8	1994	Also, the excretion of beta 2-microglobulin and N-acetyl-beta-glucosaminidase increased from 10.98 +/- 4.62 to 11.86 +/- 4.74 mg/24 h (P &lt; 0.05) and from 19.7 +/- 4.2 to 25.3 +/- 7.0 nmol/h per micromoles of creatinine (P = 0.05), respectively.	Creatinine	211-221	beta-2-microglobulin	Homo sapiens	23-43
7988029-3	1994	Urinary beta 2-microglobulin increased from negligible levels (median 0.01 mg/mmol creatinine) to peak at 4 h (median 4.55 mg/mmol), in part due to interference with its reabsorption by the plasma volume expander Haemaccel.	Creatinine	83-93	beta-2-microglobulin	Homo sapiens	8-28
8058986-6	1994	There were found the significant correlations between plasma creatinine and Myo levels in uremic patients.	Creatinine	61-71	myoglobin	Homo sapiens	76-79
8289410-2	1993	Creatinine clearance (CrCl) from the subject"s initial home TPN clinic visit and at present were estimated from standard formulas and compared.	Creatinine	0-10	CRCL	Homo sapiens	22-26
18949734-7	2008	Using multiple regression analysis (0.45 CPK + 2.5 LDH + 2,700 K + 2,000 uric acid - 14,000)/10,000, was most predictive for serum creatinine on day 3.	Creatinine	131-141	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	41-44
19102867-5	2008	Multiple regression analysis showed that age, Hb, pulse rate, SBP, TC, gender, TG and creatinine were significantly related to BNP and age, creatinine, Hb, gender, TG, TC, SBP, pulse rate were significantly related to NT-proBNP.	Creatinine	86-96	natriuretic peptide B	Homo sapiens	127-130
19102867-5	2008	Multiple regression analysis showed that age, Hb, pulse rate, SBP, TC, gender, TG and creatinine were significantly related to BNP and age, creatinine, Hb, gender, TG, TC, SBP, pulse rate were significantly related to NT-proBNP.	Creatinine	86-96	selenium binding protein 1	Homo sapiens	172-175
19102867-10	2008	CONCLUSION: In this study population, NT-proBNP and BNP were closely associated with age, blood pressure, creatinine, pulse rate, lipid levels, gender and abdominal circumferences.	Creatinine	106-116	natriuretic peptide B	Homo sapiens	44-47
18484961-7	2008	Furthermore, LCA inhibited the cisplatin-induced kidney damage characterized by increases in the serum creatinine and blood urea nitrogen, as well as the cisplatin-induced liver damage characterized by increases in the serum alanine aminotransferase and aspartate aminotransferase.	Creatinine	103-113	clathrin, light polypeptide (Lca)	Mus musculus	13-16
8392790-3	1993	Serum thrombomodulin levels correlated positively with serum creatinine (r = 0.854, p &lt; 0.0001) and uric acid levels (r = 0.784, p &lt; 0.001).	Creatinine	61-71	thrombomodulin	Homo sapiens	6-20
8333785-4	1993	The geometric mean urinary beta 2-microglobulin concentration for 28 subjects aged 40 y or older in 1979 increased from 1,135.8 micrograms/g creatinine in 1979 to 1,999.7 micrograms/g creatinine in 1989.	Creatinine	141-151	beta-2-microglobulin	Homo sapiens	27-47
8333785-4	1993	The geometric mean urinary beta 2-microglobulin concentration for 28 subjects aged 40 y or older in 1979 increased from 1,135.8 micrograms/g creatinine in 1979 to 1,999.7 micrograms/g creatinine in 1989.	Creatinine	184-194	beta-2-microglobulin	Homo sapiens	27-47
8333785-5	1993	A similar tendency was also observed in 16 subjects with urinary beta 2-microglobulin concentrations greater than 1,000 micrograms/g creatinine in 1979, although the statistical significance of the difference did not reach the 5% level, probably because of the small sample size.	Creatinine	133-143	beta-2-microglobulin	Homo sapiens	65-85
18223261-7	2008	RESULTS: Urinary alpha(2)-AP-resistant plasmin activity corrected for creatinine concentration (units/g x creatinine) was significantly higher in patients with APSGN (2.99 +/- 0.63) than in patients with IgAN (1.02 +/- 0.20, P &lt; 0.01), SI (0.79 +/- 0.17, P &lt; 0.01), or in healthy control subjects (0.73 +/- 0.18, P &lt; 0.01).	Creatinine	70-80	plasminogen	Homo sapiens	39-46
18223261-7	2008	RESULTS: Urinary alpha(2)-AP-resistant plasmin activity corrected for creatinine concentration (units/g x creatinine) was significantly higher in patients with APSGN (2.99 +/- 0.63) than in patients with IgAN (1.02 +/- 0.20, P &lt; 0.01), SI (0.79 +/- 0.17, P &lt; 0.01), or in healthy control subjects (0.73 +/- 0.18, P &lt; 0.01).	Creatinine	106-116	plasminogen	Homo sapiens	39-46
18558570-1	2008	Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine.	Creatinine	182-192	cystatin C	Homo sapiens	0-10
8289988-4	1993	We have observed a high frequency of hematuria, abnormal microalbuminuria and elevation of urinary beta 2-microglobulin in these patients still with normal serum creatinine.	Creatinine	162-172	beta-2-microglobulin	Homo sapiens	99-119
1465411-3	1992	Compared to rats administered vehicle, rats administered IGF-I (100 micrograms/day via continuous subcutaneous infusion) had significantly lower serum creatinine and blood urea nitrogen levels over the course of 7 days postocclusion.	Creatinine	151-161	insulin-like growth factor 1	Rattus norvegicus	57-62
1466355-8	1992	High beta 2M levels were more common among patients with older age, with elevated creatinine, bilirubin, and alkaline phosphatase levels, with low albumin levels, and with B-cell disease.	Creatinine	82-92	beta-2-microglobulin	Homo sapiens	5-12
1466355-9	1992	Multivariate analysis for survival indicated the beta 2M level to be an independent prognostic variable (after adjusting for pretreatment creatinine level and age).	Creatinine	138-148	beta-2-microglobulin	Homo sapiens	49-56
1447935-9	1992	CONCLUSIONS: Beta 2-microglobulin is one of the most important independent prognostic factors in multiple myeloma with its prognostic value being greatest when used uncorrected according to the values of creatinine.	Creatinine	204-214	beta-2-microglobulin	Homo sapiens	13-33
1475408-2	1992	The EGF/creatinine ratio in urine was significantly higher for women (range and (median); 0.20-0.83 (0.50) nmol EGF/mmol creatinine) than for men (0.17-0.63 (0.30) nmol EGF/mmol creatinine).	Creatinine	8-18	epidermal growth factor	Homo sapiens	112-115
1475408-2	1992	The EGF/creatinine ratio in urine was significantly higher for women (range and (median); 0.20-0.83 (0.50) nmol EGF/mmol creatinine) than for men (0.17-0.63 (0.30) nmol EGF/mmol creatinine).	Creatinine	8-18	epidermal growth factor	Homo sapiens	112-115
1475408-2	1992	The EGF/creatinine ratio in urine was significantly higher for women (range and (median); 0.20-0.83 (0.50) nmol EGF/mmol creatinine) than for men (0.17-0.63 (0.30) nmol EGF/mmol creatinine).	Creatinine	121-131	epidermal growth factor	Homo sapiens	4-7
1475408-2	1992	The EGF/creatinine ratio in urine was significantly higher for women (range and (median); 0.20-0.83 (0.50) nmol EGF/mmol creatinine) than for men (0.17-0.63 (0.30) nmol EGF/mmol creatinine).	Creatinine	121-131	epidermal growth factor	Homo sapiens	4-7
1411368-3	1992	Beta 2-microglobulin was slightly increased in those welders with a urinary chromium concentration of greater than 64.5 nmol.mmol-1 creatinine.	Creatinine	132-142	beta-2-microglobulin	Homo sapiens	0-20
18558570-1	2008	Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine.	Creatinine	182-192	cystatin C	Homo sapiens	0-10
18712044-6	2008	Reductions in BNP and urinary albumin/creatinine ratio (UAR) levels were significantly correlated with the reductions in systolic BP levels (BNP, clinic/morning BP: r = 0.256, p = 0.030/r = 0.330, p = 0.005; UAR, clinic BP: r = 0.316, p = 0.007).	Creatinine	38-48	natriuretic peptide B	Homo sapiens	141-144
18445894-8	2008	The serum cystatin C level had a significant correlation with the body mass index (BMI) (r = 0.155; p = 0.007) and a correlation with serum creatinine as well (r = 0.009; p = 0.873).	Creatinine	140-150	cystatin C	Homo sapiens	10-20
17967418-7	2008	Few studies reported independent associations and of those that did age, female gender, and creatinine concentrations were positively associated with BNP and NT-proBNP.	Creatinine	92-102	natriuretic peptide B	Homo sapiens	150-153
1381383-5	1992	RESULTS: All 31 patients with plasma creatinine greater than 200 mumol/l excreted increased amounts of beta 2-glycoprotein-1, retinol-binding protein, and alpha 1-microglobulin, and 29 had increased N-acetyl-beta-D-glucosaminidase; the quantities were generally similar to those found in comparable patients with primary tubular pathology.	Creatinine	37-47	apolipoprotein H	Homo sapiens	103-124
1381383-6	1992	Among 58 with plasma creatinine concentrations under 200 mumol/l, increases in beta 2-glycoprotein-1, retinol-binding protein, and alpha 1-microglobulin excretion were less common and much smaller, especially in those with obstructive nephropathy and polycystic disease.	Creatinine	21-31	apolipoprotein H	Homo sapiens	79-100
1381383-8	1992	CONCLUSIONS: Increased excretion of beta 2-glycoprotein-1 due to a raised plasma concentration or diminution of tubular reabsorption, or both, is common in all the forms of renal disease investigated, and both plasma creatinine and urinary albumin must be taken into account when interpreting results.	Creatinine	217-227	apolipoprotein H	Homo sapiens	36-57
1580447-11	1992	In the steroid-unresponsive group, the likelihood ratios for urinary RBP greater than 4000 micrograms/g creatinine and for B2M greater than 3000 micrograms/g creatinine were 3.8 and 3.0, respectively.	Creatinine	158-168	beta-2-microglobulin	Homo sapiens	123-126
1580447-12	1992	The probability was 100% that values of RBP of less than 1300 micrograms/g creatinine and B2M of less than 130 micrograms/g creatinine were from steroid-responsive patients.	Creatinine	124-134	beta-2-microglobulin	Homo sapiens	90-93
17704953-7	2008	Their corresponding creatinine-corrected markers did not vary significantly with urinary flow rate, but the creatinine-corrected excretions of albumin, gamma-GT, and NAG were significantly higher in daytime samples than in overnight samples, with the same (non-significant) trend for A1M.	Creatinine	108-118	O-GlcNAcase	Homo sapiens	166-169
17704953-7	2008	Their corresponding creatinine-corrected markers did not vary significantly with urinary flow rate, but the creatinine-corrected excretions of albumin, gamma-GT, and NAG were significantly higher in daytime samples than in overnight samples, with the same (non-significant) trend for A1M.	Creatinine	108-118	alpha-1-microglobulin/bikunin precursor	Homo sapiens	284-287
18215705-3	2008	We investigated whether serum cystatin C concentration is related to peritoneal and renal clearances of creatinine and urea.	Creatinine	104-114	cystatin C	Homo sapiens	30-40
1569448-11	1992	The most frequent toxicities requiring dose reductions of rIL-2 were: hypotension in 87% of patients, dyspnea in 32%, CNS toxicity in 55%, and an increase in serum creatinine levels in 48%.	Creatinine	164-174	interleukin 2	Rattus norvegicus	58-63
1588770-6	1992	A significant correlation between the urinary hEGF levels and creatinine clearance (r = 0.712, p less than 0.001) and an inverse correlation between urinary hEGF levels and fractional excretion of sodium (r = -0.406, p less than 0.05) was demonstrated.	Creatinine	62-72	epidermal growth factor	Homo sapiens	46-50
1621689-5	1992	Significantly higher concentrations of beta 2-microglobulin (MG) were found in urine samples with CdU greater than 10 micrograms/g creatinine.	Creatinine	131-141	beta-2-microglobulin	Homo sapiens	39-59
1420616-2	1992	The EGF concentration of the first voided urine was higher in appropriate-for-date (AFD) neonates (33.9 +/- 23.0 ng/mg creatinine) than in those with intrauterine growth retardation (IUGR; 23.5 +/- 7.7 ng/mg creatinine, p less than 0.05) and heavy-for-date (19.8 +/- 5.2 ng/mg creatinine, p less than 0.05) neonates.	Creatinine	119-129	epidermal growth factor	Homo sapiens	4-7
1420616-2	1992	The EGF concentration of the first voided urine was higher in appropriate-for-date (AFD) neonates (33.9 +/- 23.0 ng/mg creatinine) than in those with intrauterine growth retardation (IUGR; 23.5 +/- 7.7 ng/mg creatinine, p less than 0.05) and heavy-for-date (19.8 +/- 5.2 ng/mg creatinine, p less than 0.05) neonates.	Creatinine	208-218	epidermal growth factor	Homo sapiens	4-7
1420616-2	1992	The EGF concentration of the first voided urine was higher in appropriate-for-date (AFD) neonates (33.9 +/- 23.0 ng/mg creatinine) than in those with intrauterine growth retardation (IUGR; 23.5 +/- 7.7 ng/mg creatinine, p less than 0.05) and heavy-for-date (19.8 +/- 5.2 ng/mg creatinine, p less than 0.05) neonates.	Creatinine	208-218	epidermal growth factor	Homo sapiens	4-7
1420616-4	1992	Urinary EGF concentrations of women with AFD fetuses (45.9 +/- 31.2 ng/mg creatinine) did not differ significantly from those of women with diabetes (39.9 +/- 26.8 ng/mg creatinine) or women with multiple fetuses (44.6 +/- 30.6 ng/mg creatinine).	Creatinine	74-84	epidermal growth factor	Homo sapiens	8-11
1420616-5	1992	However, women with IUGR fetuses showed lower urinary EGF concentrations (13.8 +/- 7.4 ng/mg creatinine, p less than 0.05) than women with AFD fetuses.	Creatinine	93-103	epidermal growth factor	Homo sapiens	54-57
1600330-4	1992	There were significant inverse correlations of plasma C-peptide, GIP, and gastrin immunoreactivity to endogenous creatinine clearance (kidney function).	Creatinine	113-123	gastrin	Homo sapiens	74-81
1768575-2	1991	Gentamicin half-life (Gt1/2) could be predicted from plasma creatinine concentration (PCr) (r = 0.78); the prediction was minimally but significantly increased (r = 0.81) by adding post-conceptional age to a multiple regression analysis.	Creatinine	60-70	beta-1,4-galactosyltransferase 1	Homo sapiens	22-27
1762198-4	1991	We first examined the correlation of serum myoglobin level with levels of serum creatinine and serum beta 2 microglobulin in patients without muscular damage.	Creatinine	80-90	myoglobin	Homo sapiens	43-52
1762198-5	1991	Creatinine level was more highly correlated with serum myoglobin level than with beta 2 microglobulin level.	Creatinine	0-10	myoglobin	Homo sapiens	55-64
1762198-5	1991	Creatinine level was more highly correlated with serum myoglobin level than with beta 2 microglobulin level.	Creatinine	0-10	beta-2-microglobulin	Homo sapiens	81-101
1762198-6	1991	Measured myoglobin level was corrected using the regression line obtained from the correlation between levels of myoglobin and creatinine, and the corrected myoglobin levels thus obtained were within a reasonable range.	Creatinine	127-137	myoglobin	Homo sapiens	9-18
1720317-4	1991	The linear correlations between serum creatinine and alpha 1m and creatinine and beta 2m were r = 0.7 and 0.8, respectively (P less than 0.001).	Creatinine	38-48	beta-2-microglobulin	Homo sapiens	81-88
1777968-4	1991	In renal insufficiency patients, 38 with chronic renal failure, 79 on hemodialysis and 66 on continuous ambulatory peritoneal dialysis, the mean values for SAP concentration were all significantly higher than normal (range of means, 39-59 mg/l in men and 35-42 mg/l in women), but did not correlate with serum creatinine, duration of dialysis or the presence of an acute phase response.	Creatinine	310-320	amyloid P component, serum	Homo sapiens	156-159
1931558-4	1991	All of the CSF samples showed peaks for lactate, L-alanine, acetate, glutamine, citrate, creatine/creatinine and sugar resonances.	Creatinine	98-108	colony stimulating factor 2	Homo sapiens	11-14
1840347-0	1991	Clinical significance of correction of serum beta 2-microglobulin levels for serum creatinine in multiple myeloma.	Creatinine	83-93	beta-2-microglobulin	Homo sapiens	45-65
1840347-2	1991	There was confirmed a significant relationship between serum beta 2-microglobulin and serum creatinine levels.	Creatinine	92-102	beta-2-microglobulin	Homo sapiens	61-81
2206955-1	1990	A specific two-site ELISA for human epidermal growth factor (hEGF) has been used to measure urinary hEGF/creatinine ratios in 30 normal subjects, 30 hospital in-patients with breast cancer and 30 hospital in-patients with colonic or rectal cancer.	Creatinine	105-115	epidermal growth factor	Homo sapiens	36-59
2206955-1	1990	A specific two-site ELISA for human epidermal growth factor (hEGF) has been used to measure urinary hEGF/creatinine ratios in 30 normal subjects, 30 hospital in-patients with breast cancer and 30 hospital in-patients with colonic or rectal cancer.	Creatinine	105-115	epidermal growth factor	Homo sapiens	61-65
2208710-11	1990	In patients with renal insufficiency, serum creatinine values were moderately related to serum myoglobin values (r = 0.465).	Creatinine	44-54	myoglobin	Homo sapiens	95-104
18237601-2	2008	The aim of this study was to evaluate the effects of blood hemoglobin concentration and creatinine clearance (CCr) on pro-BNP-based LV filling pressure prediction in patients with preserved LV systolic function.	Creatinine	88-98	natriuretic peptide B	Homo sapiens	122-125
18293167-10	2008	In further multivariate regression analysis, only in men, TGF-beta1 and TGF-beta3 genotypes as independent predictors had statistically significant effect on serum creatinine (p = 0.007) and urinary albumin excretion (p = 0.022), respectively.	Creatinine	164-174	transforming growth factor beta 3	Homo sapiens	72-81
18057868-8	2008	We used a mixed effects model to analyze the effect of time, race and creatinine on Lp(a) after transplant.	Creatinine	70-80	lipoprotein(a)	Homo sapiens	84-89
18057868-11	2008	Each reduction of 50% in creatinine was associated with a 10.6% reduction in Lp(a) (p &lt; 0.001).	Creatinine	25-35	lipoprotein(a)	Homo sapiens	77-82
18082491-5	2008	Cystatin C was categorized as low (&lt; 0.84 mg/L), medium (0.84-1.18 mg/L), or high (&gt; or = 1.19 mg/L); serum creatinine (cutoff value of &gt; or = 1.3 in women and &gt; or = 1.5 in men) and estimated glomerular filtration rate (eGFR; greater and less than 60 mL/min per 1.73 m2) were dichotomized.	Creatinine	114-124	cystatin C	Homo sapiens	0-10
18973461-1	2008	Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine.	Creatinine	118-128	cystatin C	Homo sapiens	0-10
18973461-2	2008	Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine.	Creatinine	170-180	cystatin C	Homo sapiens	29-39
18973461-2	2008	Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine.	Creatinine	244-254	cystatin C	Homo sapiens	29-39
18498720-2	2008	The strongest predictors of poor outcome of IgAN involve hypertension, severe proteinuria and elevated serum creatinine level.	Creatinine	109-119	IGAN1	Homo sapiens	44-48
19367005-8	2008	The sensitivity and specificity of urinary NAG-creatinine ratio for diagnosis of pyelonephritis were 73.6% and 77.3%, respectively, with a cutoff point of 10.16 U/g (area under the curve = 0.76, 95% confidence interval, 0.67 to 0.76).	Creatinine	47-57	O-GlcNAcase	Homo sapiens	43-46
17545921-5	2008	RESULTS: In rank-order correlation analysis, serum OPG concentrations had significant positive correlations with age (r = 0.29, P = 0.03), systolic blood pressure (r = 0.45, P &lt; 0.01), diastolic blood pressure (r = 0.34, P &lt; 0.01), and serum creatinine (r = 0.29, P = 0.04).	Creatinine	248-258	TNF receptor superfamily member 11b	Homo sapiens	51-54
17545921-8	2008	The correlation of serum OPG with systolic blood pressure persisted after adjustment for both age and serum creatinine.	Creatinine	108-118	TNF receptor superfamily member 11b	Homo sapiens	25-28
17845559-6	2007	A significant correlation was found between the percentage FOXP3(+) cells and markers for rejection, i.e. creatinine levels and Banff interstitial and tubular infiltrate scores.	Creatinine	106-116	forkhead box P3	Homo sapiens	59-64
17889128-10	2007	Only five patients showed an increase in serum creatinine more than 20% (from 1.44 +/- 0.41 to 1.94 +/- 0.45 mg/dL P = .04) and proteinuria did not increase (P = .94).	Creatinine	47-57	dally-like	Drosophila melanogaster	112-118
17629825-12	2007	CIN was defined as a serum creatinine level &lt;134 micromol/l on admission and a 25% increase of that parameter, with a value &gt;133 micromol/l within 48 hours after PCI.	Creatinine	27-37	pyridoxal phosphatase	Homo sapiens	0-3
2078920-2	1990	As compared to the euthyroid state, the athyrodism was associated with a drop in the urinary EGF excretion from 24.8 +/- 8.4 to 11.8 +/- 4.6 ng/mg creatinine (p less than 0.0001) and some increase in the EGF level in blood serum from 159.5 +/- 55.0 to 191.2 +/- 41.0 pM (p = 0.023).	Creatinine	147-157	epidermal growth factor	Homo sapiens	93-96
2130298-4	1990	In 18 patients studied with variable degrees of residual renal function, serum beta 2-M concentration increased with declining renal function; this was most marked when the creatinine clearance was less than 1 ml/min.	Creatinine	173-183	beta-2-microglobulin	Homo sapiens	79-87
2309254-4	1990	The greater extent of oxidation at C-2 was evidenced by a twofold increase in the urinary excretion of 2-hydroxyestrone (2.88 +/- 0.32 versus 5.30 +/- 0.85 micrograms/g creatinine), while the excreted products of 16 alpha-hydroxylation were unchanged.	Creatinine	169-179	complement C2	Homo sapiens	35-38
17298994-12	2007	CCR1 mRNA was significantly increased in renal biopsies with acute allograft rejection (P &lt; 0.001), and with chronic allograft nephropathy (P &lt; 0.05), it correlated with the expression of CCL3 and CCL5, and with serum-creatinine.	Creatinine	224-234	C-C motif chemokine receptor 1	Homo sapiens	0-4
17498579-9	2007	B-type natriuretic peptide quartile remained highly predictive of mortality even after adjustment for age, gender, systolic blood pressure, blood urea nitrogen, creatinine, sodium, pulse, and dyspnea at rest, Q4 versus Q1 (adjusted odds ratio 2.23 [95% confidence interval 1.91 to 2.62, p &lt; 0.0001]).	Creatinine	161-171	natriuretic peptide B	Homo sapiens	0-26
17360238-6	2007	The urinary NGAL levels and NGAL/creatinine values were significantly upregulated in Lee grade III IgAN patients, in correlation with progressive glomerular mesangial proliferation and tubulointerstitial injury.	Creatinine	33-43	IGAN1	Homo sapiens	99-103
2218929-2	1990	FRK were determined as the degree of the increase of endogenous creatinine clearance after stimulation with beef protein (0.7 g per kg bw) or dopamine (3 micrograms/min per kg bw).	Creatinine	64-74	fyn related Src family tyrosine kinase	Homo sapiens	0-3
17541308-8	2007	Serum creatinine level correlated with BNP level, but neither age nor sex did.	Creatinine	6-16	natriuretic peptide B	Homo sapiens	39-42
17336697-10	2007	Cystatin C detects an association of impaired kidney function with decreased HRR and exercise capacity that is not fully captured using creatinine-based measurements.	Creatinine	136-146	cystatin C	Homo sapiens	0-10
33811534-10	2021	Moreover, within DN group, the concentration of serum CN-1 was positively correlated with uric acid (UA, r = 0.376, p = 0.026) and serum creatinine (SCr, r = 0.399, p = 0.018) and negatively correlated with serum albumin (Alb, r = - 0.348, p = 0.041) and estimated glomerular filtration rate (eGRF, r = - 0.432, p = 0.010).	Creatinine	137-147	carnosine dipeptidase 1	Homo sapiens	54-58
33811534-11	2021	Furthermore, the concentration of serum CN-1 was discovered to be positively correlated with indicators including 24-h urinary protein-creatinine ratio (24 h-U-PRO/CRE, r = 0.528, p = 0.001), urinary albumin-to-creatinine ratio (Alb/CRE, r = 0.671, p = 0.000), urinary transferrin (TRF, r = 0.658, p = 0.000), retinol-binding protein (RBP, r = 0.523, p = 0.001), N-acetyl-glycosaminidase (NAG, r = 0.381, p = 0.024), immunoglobulin G (IgG, r = 0.522, p = 0.001), cystatin C (Cys-C, r = 0.539, p = 0.001), beta-2-microglobulin (beta2-MG, r = 0.437, p = 0.009), and alpha-1-macroglobulin (alpha1-MG, r = 0.480, p = 0.004).	Creatinine	135-145	carnosine dipeptidase 1	Homo sapiens	40-44
33811534-11	2021	Furthermore, the concentration of serum CN-1 was discovered to be positively correlated with indicators including 24-h urinary protein-creatinine ratio (24 h-U-PRO/CRE, r = 0.528, p = 0.001), urinary albumin-to-creatinine ratio (Alb/CRE, r = 0.671, p = 0.000), urinary transferrin (TRF, r = 0.658, p = 0.000), retinol-binding protein (RBP, r = 0.523, p = 0.001), N-acetyl-glycosaminidase (NAG, r = 0.381, p = 0.024), immunoglobulin G (IgG, r = 0.522, p = 0.001), cystatin C (Cys-C, r = 0.539, p = 0.001), beta-2-microglobulin (beta2-MG, r = 0.437, p = 0.009), and alpha-1-macroglobulin (alpha1-MG, r = 0.480, p = 0.004).	Creatinine	211-221	carnosine dipeptidase 1	Homo sapiens	40-44
17270090-6	2007	RESULTS: Following intake of cooked meat, median serum creatinine concentration (kinetic Jaffe) increased from 80.5 micromol/L preprandially to 101.0 micromol/L 1-2 h postprandially (P&lt;0.0001), and 99.0 micromol/L 3-4 h postprandially (P&lt;0.0001).	Creatinine	55-65	LINE1 retrotransposable element 1	Homo sapiens	159-164
33793874-8	2021	Bmal1 ablation sensitized mice to Semen Strychni-induced toxicity (with increased levels of plasma creatinine and CK-BB) and abolished the time dependency of toxicity.	Creatinine	99-109	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	0-5
22237745-8	2012	RESULTS: Mean serum renalase levels in kidney allograft recipients correlated with age, time after transplantation, soluble CD44 (sCD44), VCAM, serum creatinine, estimated glomerular filtration rate (eGFR; measured by CKD-EPI, MDRD, and Cockcroft-Gault formulas), serum phosphate, urea, sCD146, vWF, and thrombomodulin and tended to correlate with tPA.	Creatinine	150-160	renalase, FAD dependent amine oxidase	Homo sapiens	20-28
22237745-11	2012	A multiple regression analysis showed that renalase was predicted in 58% by serum creatinine.	Creatinine	82-92	renalase, FAD dependent amine oxidase	Homo sapiens	43-51
17934914-10	2007	After exclusion of age, 0.1 mg/l higher concentrations of cystatin C or 10 ml/min lower estimated creatinine clearance were significantly associated with 56% and 34%, respectively, higher probability of CCA-IMT of more than 0.9 mm.	Creatinine	98-108	cystatin C	Homo sapiens	58-74
18236735-4	2007	Activities of NAG (U/mmol creatinine) were significantly elevated in groups A, B and C at 98.7 (8.6), 112.8 (12.9) and 147.4(16.2), respectively, compared with the reference range &lt;35 U/mmol creatinine (group C vs. groups A and B: P &lt; 0.01).	Creatinine	26-36	O-GlcNAcase	Homo sapiens	14-17
18236735-4	2007	Activities of NAG (U/mmol creatinine) were significantly elevated in groups A, B and C at 98.7 (8.6), 112.8 (12.9) and 147.4(16.2), respectively, compared with the reference range &lt;35 U/mmol creatinine (group C vs. groups A and B: P &lt; 0.01).	Creatinine	194-204	O-GlcNAcase	Homo sapiens	14-17
18283895-10	2007	In the group of 19 patients with CPK concentration of &gt;2000 U/L and myoglobin concentration of &gt;700 mcg/L crush syndrome developed in 6 (7.4%) patients with oliguria (urin output &lt;50 ml/h) and the increase of serum potassium, phosphate and creatinine concentrations.	Creatinine	249-259	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	33-36
17045186-10	2006	hK1 amidase activity was expressed in muM.min(-1).mL(-1) urine and in muM.min(-1).mg(-1) creatinine to correct for differences in urine flow rate.	Creatinine	89-99	keratin 1	Homo sapiens	0-3
17125594-10	2006	Glomerular and proximal tubular pSmad2/Smad3 was positively correlated with serum creatinine levels, while distal and collecting tubular pSmad2/3 and p300 correlated positively with tubular atrophy.	Creatinine	82-92	SMAD family member 3	Homo sapiens	39-44
16871242-2	2006	In the nephrotoxic mercury chloride (HgCl(2)) rat model of acute kidney failure systemically administered EP4 agonist reduced the serum creatinine values and increased the survival rate.	Creatinine	136-146	prostaglandin E receptor 4	Rattus norvegicus	106-109
16980025-9	2006	Those receiving a higher CsA dosage (&lt;2.5 mg/kg/d) showed greater femoral neck BMD, but lower serum creatinine values.	Creatinine	103-113	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	25-28
16495211-10	2006	CLC intervention at 42 and 66 h after the priming dose resulted in marked progressive elevation of plasma blood urea nitrogen and creatinine resulting in ARF and death of mice.	Creatinine	130-140	Charcot-Leyden crystal protein	Mus musculus	0-3
17074106-9	2006	By Cox regression analysis, elevated creatinine was a powerful independent hazard predictor of 30-day survival (odds ratio 4.591, 95% confidence interval 2.149 to 9.808, P = 0.000) and remained to be associated with reduced survival at 1 year (odds ratio 3.936, 95% confidence interval 2.264 to 6.845, P = 0.000).	Creatinine	37-47	cytochrome c oxidase subunit 8A	Homo sapiens	3-6
16730690-4	2006	RESULTS: CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine).	Creatinine	159-169	cystatin C	Homo sapiens	9-13
9713578-4	1997	Urinary GGT activity in the APAP administered group (n = 12) (1.88 +/- 0.21 U/mg creatinine) was significantly higher than in the control group (n = 16) (0.77 +/- 0.05 U/mg creatinine) (p &lt; 0.0002).	Creatinine	81-91	gamma-glutamyltransferase 1	Rattus norvegicus	8-11
9713578-4	1997	Urinary GGT activity in the APAP administered group (n = 12) (1.88 +/- 0.21 U/mg creatinine) was significantly higher than in the control group (n = 16) (0.77 +/- 0.05 U/mg creatinine) (p &lt; 0.0002).	Creatinine	173-183	gamma-glutamyltransferase 1	Rattus norvegicus	8-11
34903856-7	2021	At the same time, GPC-4 levels correlated negatively with estimated glomerular filtration rate (eGFR), serum protein and serum albumin levels and were positively related to creatinine and uric acid levels at GW 35-37.	Creatinine	173-183	glypican 4	Homo sapiens	18-23
34879100-12	2021	High serum creatinine was associated GM-CSF, high IL-5 and IL-6 level were correlates with lung involvement and saturation drop.	Creatinine	11-21	colony stimulating factor 2	Homo sapiens	37-43
34583417-9	2021	In terms of biochemistry, MIS-C patients had lower levels of albumin, sodium and alanine aminotransferase and higher levels of creatinine than KD patients.	Creatinine	127-137	anti-Mullerian hormone	Homo sapiens	26-29
16585276-22	2006	With a cutoff concentration of urinary IL-8/creatinine at 5 pg/micromol, the sensitivity of this marker in diagnosing VUR was 88%, the specificity 69%, the positive prognostic value 66%, and the negative prognostic value 89%.	Creatinine	44-54	VUR	Homo sapiens	118-121
16313894-3	2006	However, the relationship of circulating levels of MMP-2, -9 and serum creatinine in the patients of chronic kidney disease (CKD) has not yet been investigated.	Creatinine	71-81	matrix metallopeptidase 2	Homo sapiens	51-60
34926510-3	2021	To measure GFR, the knowledge about the physiologic processes at the nephron level, the concept of clearance, and the identification of creatinine as a suitable endogenous marker for measuring the creatinine clearance (CrCl) had to be previously developed.	Creatinine	197-207	CRCL	Homo sapiens	219-223
34800044-2	2021	Serum creatinine is the most commonly used biomarker for assessing kidney function and is utilized in different equations for estimating creatinine clearance (CrCL) or glomerular filtration rate (GFR).	Creatinine	6-16	CRCL	Homo sapiens	159-163
34800044-2	2021	Serum creatinine is the most commonly used biomarker for assessing kidney function and is utilized in different equations for estimating creatinine clearance (CrCL) or glomerular filtration rate (GFR).	Creatinine	137-147	CRCL	Homo sapiens	159-163
34643859-12	2022	Furthermore, TRIM3 overexpression significantly eased the LPS-induced damage on AKI rat model and decreased the serum creatinine and urea nitrogen levels in rat kidney tissues.	Creatinine	118-128	tripartite motif-containing 3	Rattus norvegicus	13-18
34615677-9	2021	RESULTS: The urine Cyr61-to-creatinine ratio (UCyr61CR) increased significantly in patients with stage 4 or 5 CKD.	Creatinine	28-38	cellular communication network factor 1	Homo sapiens	19-24
34765333-5	2021	Renal function was calculated by using Cockroft-Gault equation, expressed as Creatinine Clearance (CrCl).	Creatinine	77-87	CRCL	Homo sapiens	99-103
34344244-7	2021	Results: Double negative CD69 and CD56 (47.9%) multiple myeloma cases were associated with high serum beta2 microglobulin, creatinine, calcium and low serum albumin.	Creatinine	123-133	neural cell adhesion molecule 1	Homo sapiens	34-38
16313894-6	2006	In addition, serum creatinine concentrations correlated with MMP-2 activity (R=0.288, p&lt;0.05) and inversely correlated with that of MMP-9 (R=0.344, p&lt;0.01).	Creatinine	19-29	matrix metallopeptidase 2	Homo sapiens	61-66
16313894-7	2006	CONCLUSIONS: This study demonstrated a correlation between MMP-2, -9 and serum creatinine in CKD patients to suggest that MMP-2 and MMP-9 might contribute in the pathogenesis of CKD.	Creatinine	79-89	matrix metallopeptidase 2	Homo sapiens	59-68
16313894-7	2006	CONCLUSIONS: This study demonstrated a correlation between MMP-2, -9 and serum creatinine in CKD patients to suggest that MMP-2 and MMP-9 might contribute in the pathogenesis of CKD.	Creatinine	79-89	matrix metallopeptidase 2	Homo sapiens	59-64
16516040-7	2006	RESULTS: Mean urine MIF amounts +/- SEM determined by enzyme-linked immunosorbent assay were significantly greater in 14 patients with UTI compared to that in 16 controls (1.96 +/- 0.40 vs 0.59 +/- 0.09 ng/mg creatinine, p &lt;0.01).	Creatinine	209-219	macrophage migration inhibitory factor	Homo sapiens	20-23
16487258-5	2006	These haemodynamic effects probably contribute to the side-effects of BNP in patients with acute CHF with a 27% incidence of hypotension and possibly to 22% worsening of renal function, defined as an increase in serum creatinine of 0.5 mg/dL, associated with a worse prognosis.	Creatinine	218-228	natriuretic peptide B	Homo sapiens	70-73
34465681-9	2021	RESULTS: Creatinine, urea nitrogen, urine protein, and malondialdehyde (MDA) in the model group were significantly increased and inhibited by Echinacoside and alpha-Klotho treatment with Echinacoside dose-dependence.	Creatinine	9-19	Klotho	Rattus norvegicus	165-171
34103333-9	2021	The injection of PHD2-siRNA-G5-FA significantly alleviated renal I/R injury, as shown by the inhibition of increases in serum creatinine and BUN, the blockade of increases in KIM-1 and NGAL and the improvement of histological damage compared with mice treated with control siRNA.	Creatinine	126-136	egl-9 family hypoxia-inducible factor 1	Mus musculus	17-21
34475909-10	2021	Conclusion: SGLT2i significantly improved glycemic control, BMI, and serum creatinine in the Pakistani population with a very low number of observed adverse events.	Creatinine	75-85	solute carrier family 5 member 2	Homo sapiens	12-17
16001213-12	2006	NAG activity was greater in the exposed group compared to control group (median 3.5 U/g creatinine vs 1.9 U/g creatinine, z=2.6, P=0.009).	Creatinine	88-98	O-GlcNAcase	Homo sapiens	0-3
34225678-14	2021	Using serum creatinine level doubled of the baseline or reached end-stage renal disease as the endpoint, the prognosis of IgA-dominant postinfectious glomerulonephritis patients was worse than that of primary IgA nephropathy patients (p = 0.013).	Creatinine	12-22	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	122-125
34262329-6	2021	The serum iron, serum ferritin, transferrin saturation (TSAT), and hsCRP were higher, pre-dialysis creatinine and albumin were lower, and the scores of health-related qualities of life were worse in the high-level hepcidin-25 group than in the low-level hepcidin-25 group.	Creatinine	99-109	hepcidin antimicrobial peptide	Homo sapiens	214-222
34248951-11	2021	For patients with renal involvement, HE4 was positively correlated with creatinine (r=0.588, p=0.021) and negatively correlated with estimated glomerular filtration rate (r= -0.599, p=0.030).	Creatinine	72-82	WAP four-disulfide core domain 2	Homo sapiens	37-40
16001213-12	2006	NAG activity was greater in the exposed group compared to control group (median 3.5 U/g creatinine vs 1.9 U/g creatinine, z=2.6, P=0.009).	Creatinine	110-120	O-GlcNAcase	Homo sapiens	0-3
16752802-8	2006	Serum PAPP-A levels in all studied patients correlated positively with serum creatinine (r=0.395, p&lt;0.05).	Creatinine	77-87	pappalysin 1	Homo sapiens	6-12
16898529-8	2006	RESULTS: sIL-17 and uIL-17 concentrations (51.66 +/- 8.38 pg/mg and 56.29 +/-14.24 pg/mg creatinine (cr), respectively) were significantly higher (p&lt;0.001) in group I compared with group II (35.7 +/- 10.18 pg/ml and 17.47 +/- 3.46 pg/mg cr) and normal controls (27.17 +/- 1.87 pg/ml and 13.91 +/- 1.22 pg/mg cr).	Creatinine	89-99	STIL centriolar assembly protein	Homo sapiens	9-12
16236602-1	2005	We have previously shown that the thrombin inhibiting agent melagatran markedly prolongs aPTT and counteracts creatinine increase in endotoxemic pigs.	Creatinine	110-120	coagulation factor II, thrombin	Sus scrofa	34-42
16331812-10	2005	(4) The concentrations of urea nitrogen and creatinine in cyst fluid of E15 and E16 metanephroi were increased 40-fold and 50-fold, which were comparable to those in bladder urine.	Creatinine	44-54	solute carrier family 7 member 5	Rattus norvegicus	80-83
16115489-14	2005	OPG was positively correlated with Bollinger score of disease (r=0.31; p&lt;0.02), age (r=0.58; p&lt;0.01) and creatinine-values (r=0.32; p&lt;0.01) and negatively correlated with ABI (r=-0.39; p&lt;0.03).	Creatinine	111-121	TNF receptor superfamily member 11b	Homo sapiens	0-3
16115489-15	2005	CONCLUSION: In patients with PAD, plasma OPG concentrations were significantly higher in subjects with ischemic ulcerations than in those without and were positively correlated with higher severity grade of disease, age and creatinine-values.	Creatinine	224-234	TNF receptor superfamily member 11b	Homo sapiens	41-44
15954900-7	2005	Mean soluble EPCR correlated positively with serum creatinine (R= 0.3429, P &lt; 0.0001).	Creatinine	51-61	protein C receptor	Homo sapiens	13-17
15882666-8	2005	Cystatin C levels were positively correlated with age, triglyceride/HDL cholesterol ratio and creatinine, and negatively with HDL cholesterol and the number of A alleles.	Creatinine	94-104	cystatin C	Homo sapiens	0-10
15820781-3	2005	METHODS: We measured serum XT-I activity in 236 patients with different serum creatinine levels.	Creatinine	78-88	xylosyltransferase 1	Homo sapiens	27-31
15820781-4	2005	RESULTS: XT-I activities in cohorts with increased creatinine levels were not significantly altered compared to controls.	Creatinine	51-61	xylosyltransferase 1	Homo sapiens	9-13
16043942-7	2005	In the original cohort, age- and sex-specific reference values for high plasma BNP levels were related to the presence of major ECG abnormalities, hypertension, mildly elevated serum creatinine levels, and a history of coronary heart disease.	Creatinine	183-193	natriuretic peptide B	Homo sapiens	79-82
34117325-6	2021	Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST.	Creatinine	66-76	fatty acid binding protein 4	Homo sapiens	33-38
34200585-11	2021	Blood creatinine was significantly lowered by dietary egg lysozyme compared with the control and ZnB-treated rabbits (p < 0.05).	Creatinine	6-16	lysozyme C-like	Oryctolagus cuniculus	58-66
34141863-4	2021	We propose a new logistic model (ALC-Shock score) based on three easy parameters (age, serum creatinine and serum lactate at the ICU admission) as a powerful predictor of survival or successful bridge to heart replacement therapy at 28-day follow-up in this specific population.	Creatinine	93-103	allantoicase	Homo sapiens	33-36
34169427-5	2021	The multivariate analysis showed that light chain type and beta-2 micro-globulin (beta-2M) were associated factors with the decrease of serum creatinine.	Creatinine	142-152	beta-2-microglobulin	Homo sapiens	59-80
34169427-5	2021	The multivariate analysis showed that light chain type and beta-2 micro-globulin (beta-2M) were associated factors with the decrease of serum creatinine.	Creatinine	142-152	alpha-2-macroglobulin	Homo sapiens	82-89
34472785-4	2021	METHODS: The study included Type 2 Diabetic individuals with 45 of them having normoalbuminuria, 40 patients with microalbuminuria and 40 of them with macroalbuminuria (based on the albumin-creatinine ratio - ACR) and 45 non diabetic healthy controls from a medical college hospital from South India.	Creatinine	190-200	acrosin	Homo sapiens	209-212
34368799-4	2021	Methods: We performed a cohort study comparing urinary albumin (mug):creatinine (mg) ratio (ACR) in CD patients vs controls and in response to a GFD.	Creatinine	69-79	acrosin	Homo sapiens	92-95
34267439-8	2021	A significant positive correlation was found between CDK-1 gene expressions with urinary albumin/creatinine ratio.	Creatinine	97-107	cyclin dependent kinase 1	Homo sapiens	53-58
35436512-4	2022	Wasp venom caused significant increases in all biochemical parameters (aspartate aminotransferase, creatine kinase, free hemoglobin, lactate dehydrogenase, myoglobin, and plasma creatinine) within 8 h of venom administration, as well as marked alterations in renal function (a decrease in glomerular filtration rate leading to oliguria).	Creatinine	178-188	WASP actin nucleation promoting factor	Rattus norvegicus	0-4
35405247-7	2022	Spearman"s analysis showed that CD19(+)CD5(+) B cells were negatively correlated with high sensitivity C-reactive protein (hsCRP), beta2-microglobulin (beta2-MG), serum creatinine (SCr), pro-brain natriuretic peptide (pro-BNP), high-sensitivity troponin T (TNT-hs), left ventricle end-diastolic dimension (LVDD), left ventricle end-systolic dimension (LVSD) and left ventricular mass (LVM), and CD19(+)CD5(-) B cells were negatively correlated with beta2-MG, SCr, pro-BNP and TNT-hs (P < 0.05).	Creatinine	169-179	CD5 molecule	Homo sapiens	39-42
35385482-2	2022	Increased OPN mRNA and protein expression correlates with proteinuria, reduced creatinine clearance, and kidney fibrosis in animal models of kidney disease.	Creatinine	79-89	secreted phosphoprotein 1	Homo sapiens	10-13
15561971-4	2005	IRI induced an elevation of plasma creatinine that was reduced with Cl(2)MBP (26% of control).	Creatinine	35-45	myelin basic protein	Mus musculus	73-76
15774046-8	2005	Our data showed that serum cystatin C correlated better with GFR than did creatinine (1/cystatin C versus CCr: r = 0.832, P &lt; 0.001; 1/creatinine versus CCr: r = 0.426, P = 0.002).	Creatinine	74-84	cystatin C	Homo sapiens	88-98
15774046-8	2005	Our data showed that serum cystatin C correlated better with GFR than did creatinine (1/cystatin C versus CCr: r = 0.832, P &lt; 0.001; 1/creatinine versus CCr: r = 0.426, P = 0.002).	Creatinine	138-148	cystatin C	Homo sapiens	27-37
15774046-9	2005	Cystatin C was diagnostically superior to creatinine (area under the curve [AUC] for cystatin C 0.927, 95% confidence interval 86.1-99.4; AUC for creatinine 0.694, 95% confidence interval 54.1-84.6).	Creatinine	146-156	cystatin C	Homo sapiens	0-10
16433158-14	2005	A strong correlation was found between serum cystatin C and serum creatinine.	Creatinine	66-76	cystatin C	Homo sapiens	45-55
35255258-11	2022	In vivo, Irisin decreased serum creatinine, urea and phosphorous levels in chronic kidney disease (CKD) mice.	Creatinine	32-42	fibronectin type III domain containing 5	Homo sapiens	9-15
35443602-15	2022	Interestingly, the ISS stage of respective MM patients was positively correlated with Cr (tau = 0.392), while it was negatively correlated with Hb (tau = -0.364).	Creatinine	86-88	microtubule associated protein tau	Homo sapiens	90-93
35051728-9	2022	Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months).	Creatinine	67-77	leptin	Homo sapiens	28-34
35123793-2	2022	Most guidelines recommend measured GFR (mGFR) using exogenous markers with creatinine clearance (CrCl) as an alternative.	Creatinine	75-85	CRCL	Homo sapiens	97-101
35133180-9	2022	Serum FGF-23 concentrations significantly correlated with serum tCa (r = 0.511, P = 0.003) and blood iCa concentrations (r = 0.425, P = 0.015) but not serum creatinine (r = 0.279, P = 0.122) or phosphorus concentrations (r = 0.208, P = 0.253).Conclusions and relevance Increased serum FGF-23 concentrations were associated with hypercalcaemia independently of creatinine and phosphate status in cats with CKD and upper urolithiasis.	Creatinine	360-370	fibroblast growth factor 23	Felis catus	6-12
35098433-8	2022	In multivariable logistic regression analysis, logarithm-transformed urinary albumin-to-creatinine ratio (log ACR) (odds ratio (OR) 1.834;95% confidence interval (CI) 1.253-2.685; P = 0.002) and total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) (OR 1.345; 95% CI 1.079-1.677; P = 0.008) were independently associated with CKD progression.	Creatinine	88-98	acrosin	Homo sapiens	110-113
2490269-1	1989	The effect of abstinence from smoking on the urinary hydroxyproline to creatinine ratio (HOP ratio) was assessed in 49 smokers who participated in an anti-smoking course.	Creatinine	71-81	HOP homeobox	Homo sapiens	89-92
2800925-1	1989	We have previously demonstrated that changes in urinary epidermal growth factor/creatinine ratios relate to gestational age and gender.	Creatinine	80-90	epidermal growth factor	Homo sapiens	56-79
2700400-2	1989	Statistically significant positive correlations were found between the concentrations of creatinine and the C-terminal fragment (r = 0.6656, p less than 0.001), creatinine and beta 2-microglobulin (r = 0.7752, p less than 0.001) and beta 2-microglobulin and the C-terminal fragment (r = 0.6391, p less than 0.001).	Creatinine	89-99	beta-2-microglobulin	Homo sapiens	233-253
2644608-2	1989	In patients with daily protein excretion exceeding 300 mg there was a significant positive correlation between serum creatinine, daily (24-hour) protein excretion, and B2M level of the serum and urine.	Creatinine	117-127	beta-2-microglobulin	Homo sapiens	168-171
15702404-5	2005	The levels of CTH and CDH were related to both creatinine and sphingomyelin.	Creatinine	47-57	V-set and immunoglobulin domain containing 2	Homo sapiens	14-17
2643313-8	1989	In patients with chronic renal failure, beta 2M levels paralleled the increase in serum creatinine.	Creatinine	88-98	beta-2-microglobulin	Homo sapiens	40-47
2527539-6	1989	There was a significant correlation between ACE inhibition at 24 h and creatinine clearance (CrCL).	Creatinine	71-81	CRCL	Homo sapiens	93-97
2793071-3	1989	Relative hEGF concentrations in urine (micrograms/g creatinine) decreased significantly in both sexes between 24 and 64 years of age.	Creatinine	52-62	epidermal growth factor	Homo sapiens	9-13
2793071-7	1989	The significance of the increased urinary excretion of hEGF (micrograms/g creatinine) in pregnancy is not known.	Creatinine	74-84	epidermal growth factor	Homo sapiens	55-59
15610114-7	2004	The median creatinine level before surgery was 14 mg/L, which increased to 16 mg/L 6 months afterward, and at 1 and 2 years after surgery it was 15 mg/L.	Creatinine	11-21	angiotensin II receptor type 1	Homo sapiens	81-117
3260708-3	1988	Urinary EGF, measured with radioimmunoassay decreased in 10 hyperthyroid patients from 68.0 (38.0-122.9) to 40.9 (23.6-100.3) micrograms/g creatinine (P less than 0.001) and increased in 7 hypothyroid subjects from 23.8 (17.5-35.8) to 36.1 (24.7-60.1) micrograms/g creatinine (P less than 0.05).	Creatinine	139-149	epidermal growth factor	Homo sapiens	8-11
3260708-3	1988	Urinary EGF, measured with radioimmunoassay decreased in 10 hyperthyroid patients from 68.0 (38.0-122.9) to 40.9 (23.6-100.3) micrograms/g creatinine (P less than 0.001) and increased in 7 hypothyroid subjects from 23.8 (17.5-35.8) to 36.1 (24.7-60.1) micrograms/g creatinine (P less than 0.05).	Creatinine	265-275	epidermal growth factor	Homo sapiens	8-11
3260708-4	1988	In hyperthyroidism, but not in hypothyroidism, the urinary excretion of creatinine changed significantly from 0.66 (0.26-1.21) to 1.52 (0.81-2.59) g/l (P less than 0.001) during treatment, thus affecting the EGF excretion values.	Creatinine	72-82	epidermal growth factor	Homo sapiens	208-211
3291982-1	1988	Beta 2-microglobulin (beta 2M) has been proposed as a prognostic factor in multiple myeloma (MM), but beta 2M levels are reported to correlate with other prognostic indicators such as stage and creatinine level.	Creatinine	194-204	beta-2-microglobulin	Homo sapiens	102-109
3291982-6	1988	Stage and creatinine level were closely related to beta 2M level and were no longer predictive of outcome after adjustment for age and beta 2M.	Creatinine	10-20	beta-2-microglobulin	Homo sapiens	51-58
3378319-5	1988	Concentrations of the classical markers urea, uric acid, creatinine, and phosphate were closely related to PC2 in these patients.	Creatinine	57-67	chromobox 4	Homo sapiens	107-110
3261690-5	1988	Univariate analysis indicated that the amount of urinary EGF was significantly correlated with urinary creatinine (P less than 0.001), age (P less than 0.001), urinary androsterone (P less than 0.02) or aetiocholanolone (P less than 0.02), height (P less than 0.05) and weight (P less than 0.05).	Creatinine	103-113	epidermal growth factor	Homo sapiens	57-60
3261690-6	1988	However, multivariate analysis showed that the amount of urinary EGF was correlated only with creatinine excretion (P less than 0.001) and age (P less than 0.001) and that the significance of the other correlations were probably due to the confounding influence of creatinine.	Creatinine	94-104	epidermal growth factor	Homo sapiens	65-68
3261690-6	1988	However, multivariate analysis showed that the amount of urinary EGF was correlated only with creatinine excretion (P less than 0.001) and age (P less than 0.001) and that the significance of the other correlations were probably due to the confounding influence of creatinine.	Creatinine	265-275	epidermal growth factor	Homo sapiens	65-68
15240565-6	2004	Compared with nontransgenic controls, transgenic mice overexpressing ORP150 subjected to renal I/R displayed a blunted rise of serum creatinine and blood urea nitrogen, and enhanced survival of TAL, consistent with cytoprotection.	Creatinine	133-143	hypoxia up-regulated 1	Mus musculus	69-75
3413294-4	1988	Significant correlations between plasma levels of IR-7B2 and those of blood urea nitrogen, creatinine and beta 2-microglobulin were evident in non-dialyzed CRF patients.	Creatinine	91-101	secretogranin V	Homo sapiens	53-56
2907868-5	1987	The circadian acrophases of urinary GGT and LAP activity led in timing the circadian rhythms in urine volume and creatinine excretion by about 13 hr.	Creatinine	113-123	gamma-glutamyltransferase 1	Rattus norvegicus	36-39
3817736-9	1987	In the antithrombin III group and the antithrombin III plus heparin group, however, creatinine clearance was moderately elevated while FENa and CH2O remained unchanged as compared with the values before the burn.	Creatinine	84-94	serpin family C member 1	Homo sapiens	38-54
3817736-10	1987	The antithrombin III plus heparin group showed slightly better results than the antithrombin III group in Ucr/Pcr ratio, creatinine clearance and CH2O.	Creatinine	121-131	serpin family C member 1	Homo sapiens	4-20
15248059-1	2004	Clinical trials in adult liver and heart recipients have shown that management of cyclosporine (CsA) dose with 2-h levels (C2) leads to lower rejection rates and serum creatinine levels compared with C0 monitoring.	Creatinine	168-178	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	96-99
15325928-5	2004	Multivariable analysis showed that decreased left ventricular ejection fraction, angiographic coronary artery disease, and increased serum creatinine were independent predictors of elevated BNP.	Creatinine	139-149	natriuretic peptide B	Homo sapiens	190-193
15273557-12	2004	However, IL-18 therapy significantly elevated the serum ALT and creatinine levels, thus suggesting that the mortality was induced by an exaggerated form of shock/multiorgan failure.	Creatinine	64-74	interleukin 18	Mus musculus	9-14
15127324-9	2004	Cys C was positively correlated with beta2-microglobulin and creatinine and negatively with GFR values; beta2-microglobulin was also positively correlated with serum creatinine in microalbuminurics.	Creatinine	61-71	cystatin C	Homo sapiens	0-5
15086483-9	2004	RESULTS: Older age, male gender, greater weight, greater height, current cigarette smoking, and higher serum C-reactive protein (CRP) levels were independently associated with higher serum cystatin C levels after adjusting for creatinine clearance.	Creatinine	227-237	cystatin C	Homo sapiens	189-199
15086483-10	2004	After adjusting for age, weight, and gender, the partial Spearman correlations between creatinine and, respectively, serum cystatin C level and serum creatinine level were -0.29 (P &lt; 0.001) and -0.42 (P &lt; 0.001), respectively.	Creatinine	87-97	cystatin C	Homo sapiens	123-133
15086483-10	2004	After adjusting for age, weight, and gender, the partial Spearman correlations between creatinine and, respectively, serum cystatin C level and serum creatinine level were -0.29 (P &lt; 0.001) and -0.42 (P &lt; 0.001), respectively.	Creatinine	150-160	cystatin C	Homo sapiens	123-133
15617631-8	2004	Serum cystatin C showed a significant correlation with creatinine clearance at the 0.01 level (2-tailed) with an r-value of -0.311.	Creatinine	55-65	cystatin C	Homo sapiens	6-16
3499698-4	1987	A negative correlation was found between 1) the urinary concentration of EGF/URO and increasing age, and 2) the excretion of EGF/URO per mol creatinine.	Creatinine	141-151	epidermal growth factor	Homo sapiens	125-132
3630435-12	1987	The comparison of clinical data with morphological findings showed relationships between the degree of proteinuria and creatinine level increase with the histological type of IgA nephritis and with the degree of glomerular sclerosis, tubulointerstitial lesions, and electron microscopically proved glomerular basement membrane deposits.	Creatinine	119-129	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	175-178
14669429-8	2003	Urinary NAG activity was measured in the second morning urine samples by colorimetric method and the results were expressed as NAG/creatinine ratios (NAG/Cr).	Creatinine	131-141	O-GlcNAcase	Homo sapiens	8-11
3550072-2	1986	Raised beta 2-M was found in 16.4% of patients with only extrarenal manifestations of SLE, in 29.2% of patients with renal manifestation but an endogenous creatinine clearance greater than 80 ml/min/1.73 m2 and in 65.7% of patients with decreased creatinine clearance.	Creatinine	155-165	beta-2-microglobulin	Homo sapiens	7-15
3550072-2	1986	Raised beta 2-M was found in 16.4% of patients with only extrarenal manifestations of SLE, in 29.2% of patients with renal manifestation but an endogenous creatinine clearance greater than 80 ml/min/1.73 m2 and in 65.7% of patients with decreased creatinine clearance.	Creatinine	247-257	beta-2-microglobulin	Homo sapiens	7-15
3550072-3	1986	beta 2-M was higher in SLE than non-SLE glomerulonephritides matched for creatinine clearance.	Creatinine	73-83	beta-2-microglobulin	Homo sapiens	0-8
3760785-2	1986	Peak urinary glutathione-S-transferase levels occurred at the same time as maximal serum creatinine levels, and there was a significant statistical correlation between these two variables.	Creatinine	89-99	hematopoietic prostaglandin D synthase	Rattus norvegicus	13-38
3527488-4	1986	Urinary human EGF is 51.3 ng/mg creatinine for males, and 68.3 ng/mg creatinine for females.	Creatinine	32-42	epidermal growth factor	Homo sapiens	14-17
3527488-4	1986	Urinary human EGF is 51.3 ng/mg creatinine for males, and 68.3 ng/mg creatinine for females.	Creatinine	69-79	epidermal growth factor	Homo sapiens	14-17
3522000-3	1986	The serum B2-m correlated well with serum creatinine and endogenous creatinine clearance (p less than 0.01).	Creatinine	42-52	beta-2-microglobulin	Homo sapiens	10-14
3522000-3	1986	The serum B2-m correlated well with serum creatinine and endogenous creatinine clearance (p less than 0.01).	Creatinine	68-78	beta-2-microglobulin	Homo sapiens	10-14
3525426-5	1986	The healthy subjects and the control-patients showed a significant correlation between the reduction of the total Ci-clearance (ClB) and the endogenous creatinine-clearance (Clcrea) (ClB = 192 +/- 3.8 Clcrea, p less than 0.001).	Creatinine	152-162	citramalyl-CoA lyase	Homo sapiens	128-131
3525426-5	1986	The healthy subjects and the control-patients showed a significant correlation between the reduction of the total Ci-clearance (ClB) and the endogenous creatinine-clearance (Clcrea) (ClB = 192 +/- 3.8 Clcrea, p less than 0.001).	Creatinine	152-162	citramalyl-CoA lyase	Homo sapiens	183-186
12920632-6	2003	The urinary NAG activity was measured using a colorimetric method and the results were expressed as molar creatinine (Cr) ratios.	Creatinine	106-116	O-GlcNAcase	Homo sapiens	12-15
12920632-6	2003	The urinary NAG activity was measured using a colorimetric method and the results were expressed as molar creatinine (Cr) ratios.	Creatinine	118-120	O-GlcNAcase	Homo sapiens	12-15
14974366-4	2003	beta 2- and alpha 2-microglobulin (beta 2-m and alpha 2-m), albumin (alb), immunoglobulin G (IgG), total protein (tp) and creatinine (cr) concentration were measured in the second time urine specimen in 66 renal allograft recipients.	Creatinine	22-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
14526265-9	2003	A close linear relationship was observed between means of duplicates for creatinine and cystatin-C (Pearson product-moment correlation 0.92).	Creatinine	73-83	cystatin C	Homo sapiens	88-98
14526265-14	2003	CONCLUSIONS: Serum cystatin-C better discriminates among a population of type 1 and 2 diabetic patients with regard to their estimated glomerular filtration rate when compared with conventional serum creatinine measurement.	Creatinine	200-210	cystatin C	Homo sapiens	19-29
12846740-8	2003	Consistently low levels of urinary CCN2 were also detected in healthy volunteers (mean value, 7.1 CCN2/mg creatinine).	Creatinine	106-116	cellular communication network factor 2	Homo sapiens	35-39
3910076-4	1985	The strongest correlation existed between B2-m and serum creatinine (r = 0.68).	Creatinine	57-67	beta-2-microglobulin	Homo sapiens	42-46
3937528-2	1985	Urinary excretion of hEGF in patients having undergone gastric resection, expressed as a function of creatinine, was found to be somewhat decreased.	Creatinine	101-111	epidermal growth factor	Homo sapiens	21-25
6441857-7	1984	Clinical results from a subset of the patients referred directly on presentation showed that patients who inherited HLA-B7 together with DR2 had significantly higher plasma creatinines, a greater proportion of glomeruli surrounded by crescents and a worse prognosis.	Creatinine	173-184	major histocompatibility complex, class I, B	Homo sapiens	116-121
6428899-4	1984	beta 2 microglobulin clearance X 10(3) creatinine clearance rose from a mean of 0.4 (SD 0.1) to a mean of 74.5 (SD 32.3) and N-acetyl-beta-D-glucosaminidase from 54.2 units/mmol creatinine (SD 18.0) to 1525 units/mmol creatinine (SD 2318).	Creatinine	178-188	beta-2-microglobulin	Homo sapiens	0-20
6428899-4	1984	beta 2 microglobulin clearance X 10(3) creatinine clearance rose from a mean of 0.4 (SD 0.1) to a mean of 74.5 (SD 32.3) and N-acetyl-beta-D-glucosaminidase from 54.2 units/mmol creatinine (SD 18.0) to 1525 units/mmol creatinine (SD 2318).	Creatinine	178-188	beta-2-microglobulin	Homo sapiens	0-20
6341516-8	1983	Alloxan treatment caused a marked increase in serum urea-N and creatinine concentrations and insulin treatment of the alloxanized animal decreased both serum urea-N and creatinine concentrations.	Creatinine	169-179	insulin	Bos taurus	93-100
6982383-4	1982	Urinary excretion of hEGF expressed as a function of creatinine significantly decreased with increasing age, while females excreted significantly more hEGF than males.	Creatinine	53-63	epidermal growth factor	Homo sapiens	21-25
6178166-2	1982	There is a strong correlation between serum beta 2m and serum creatinine concentrations.	Creatinine	62-72	beta-2-microglobulin	Homo sapiens	44-51
6178166-6	1982	Supranormal serum beta 2m concentrations (greater than 2.4 micrograms/lm) were found in 15.5% of patients with normal serum creatinine.	Creatinine	124-134	beta-2-microglobulin	Homo sapiens	18-25
14682224-3	2003	METHODS: Urinary NAG to urinary creatinine ratio (NAG index) determined in 43 patients (5 males, 38 females) with RA who started taking the first oral dose of 10 mg of MTX.	Creatinine	32-42	O-GlcNAcase	Homo sapiens	50-53
14682224-6	2003	RESULTS: NAG-enzymuria was increased in 72.1% of the patients before administration of MTX therapy (10.8 UI/g creatinine).	Creatinine	110-120	O-GlcNAcase	Homo sapiens	9-12
14682224-9	2003	The patients with decreased creatinine clearance had before treatment higher NAG index than those with normal creatinine clearance but there was not any significant increase of NAG activity after first dose of MTX in the patients with decreased creatinine clearance.	Creatinine	28-38	O-GlcNAcase	Homo sapiens	77-80
14714862-14	2003	But high dose level of MECR and MECO significantly increased creatinine level.	Creatinine	61-71	mitochondrial trans-2-enoyl-CoA reductase	Mus musculus	23-27
12830454-4	2003	RESULTS: In men, hypertension, coronary heart disease, urinary infection, rheumatoid arthritis, glucocorticoid treatment, older age, and lower functional status were found to be significant predictors of higher Cys C values, whereas hypertension, coronary heart disease, urinary infection, older age, and increasing body mass index (BMI) significantly predicted higher Cr values.	Creatinine	369-371	cystatin C	Homo sapiens	211-216
7273606-1	1981	An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentration is presented.	Creatinine	38-48	CRCL	Homo sapiens	60-64
6790901-12	1981	This was reflected in the 3 MEH to creatinine molar ratio increase from 0.018 for controls to 0.030-0.040 in sepsis and trauma.	Creatinine	35-45	epoxide hydrolase 1	Homo sapiens	28-31
14692126-10	2003	RESULTS: In renal transplant patients as well as in control group of patients the significant correlation between creatinine clearance and reciprocal values of the serum CyC (rt = 0.828; pt &lt; 0.001; rc = 0.603; pc &lt; 0.05) and reciprocal values of the serum beta 2-MG levels (rt = 0.791; pt &lt; 0.001; rc = 0.627; pc &lt; 0.05) was found (Graph 1).	Creatinine	114-124	cystatin C	Homo sapiens	170-173
14692126-11	2003	There was a slightly better correlation between creatinine clearance and reciprocal values of the serum CyC than the one between creatinine clearance and reciprocal values of the serum beta 2-MG without statistical significance in renal transplant patients.	Creatinine	48-58	cystatin C	Homo sapiens	104-107
12501021-8	2003	Plasma creatinine correlated positively with plasma BNP.	Creatinine	7-17	natriuretic peptide B	Homo sapiens	52-55
12602117-12	2002	Serum OPG was, however, significantly correlated to serum cross laps (r = 0.71, p = 0.003), osteocalcin (r = 0.63, p = 0.01), serum parathyroid hormone (r = 0.61, p = 0.01) and serum creatinine levels (r = 0.53, p = 0.04) and showed only a weak and non-significant correlation to femoral neck Z-scores (r = -0.38, p = 0.16).	Creatinine	183-193	TNF receptor superfamily member 11b	Homo sapiens	6-9
12602117-13	2002	Multiple regression analysis revealed that serum OPG was correlated independently of PTH, serum calcium and creatinine to serum cross-laps concentrations (r = 0.63, p = 0.04).	Creatinine	108-118	TNF receptor superfamily member 11b	Homo sapiens	49-52
12195948-6	2002	An array of six potentiometric sensors, constituted by two creatinine biosensors and four ion selective electrodes for potassium, sodium, ammonium and calcium was calibrated and a multivariate model based on PLS1 for the response to creatinine was obtained and validated.	Creatinine	233-243	plastin 1	Homo sapiens	208-212
6166414-0	1981	The relationship between the renal clearance of creatinine and the apparent renal clearance of beta-2-microglobulin in patients with normal and impaired kidney function.	Creatinine	48-58	beta-2-microglobulin	Homo sapiens	95-115
7218737-2	1981	Irrespective of the underlying disease a highly significant linear correlation was found between serum immunoreactive myoglobin and serum creatinine concentration.	Creatinine	138-148	myoglobin	Homo sapiens	118-127
12104092-6	2002	RESULTS: We demonstrated a significant linear correlation between 1/cystatin C and creatinine clearance over the entire range of transplant function, comparable to that of creatinine.	Creatinine	83-93	cystatin C	Homo sapiens	68-78
7218737-3	1981	In patients with serum creatinine concentrations above 550 mu mol/1 (6.2 mg%) serum myoglobin was as a rule elevated above the range found in the controls with normal renal function.	Creatinine	23-33	myoglobin	Homo sapiens	84-93
474043-3	1979	In non-dialyzed patients with creatinine clearance above 10 ml/min a highly significant correlation between serum gastrin and creatinine clearance was found, whereas no correlation was found in patients with creatinine clearance below 10 ml/min.	Creatinine	30-40	gastrin	Homo sapiens	114-121
474043-3	1979	In non-dialyzed patients with creatinine clearance above 10 ml/min a highly significant correlation between serum gastrin and creatinine clearance was found, whereas no correlation was found in patients with creatinine clearance below 10 ml/min.	Creatinine	126-136	gastrin	Homo sapiens	114-121
474043-3	1979	In non-dialyzed patients with creatinine clearance above 10 ml/min a highly significant correlation between serum gastrin and creatinine clearance was found, whereas no correlation was found in patients with creatinine clearance below 10 ml/min.	Creatinine	126-136	gastrin	Homo sapiens	114-121
421686-4	1979	Leb-active oligosaccharides increase during pregnancy, reaching levels up to approximately 70 mumol lacto-N-difucohexaose I equivalents per pmol creatinine in the third trimester and early post-partum period.	Creatinine	145-155	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	0-3
104553-6	1979	Another hypothetical possibility is that a small increase in tubular reabsorption of both creatinine and beta2-microglobulin would account for the observed increases in creatinine and beta2-microglobulin in serum.	Creatinine	90-100	beta-2-microglobulin	Homo sapiens	184-203
104553-6	1979	Another hypothetical possibility is that a small increase in tubular reabsorption of both creatinine and beta2-microglobulin would account for the observed increases in creatinine and beta2-microglobulin in serum.	Creatinine	169-179	beta-2-microglobulin	Homo sapiens	105-124
548999-6	1979	However, the follow-up data exhibited a significantly worse prognosis (p less than 0.01) in the Bw35 positive subgroup: 9 out of 18 patients versus 4 out of 32 progressed to chronic renal failure (serum creatinine greater than 1.5 mg/dl).	Creatinine	203-213	BW35	Homo sapiens	96-100
135115-4	1976	High C1q binding activity was found preferentially in sera from patients who had diffuse rather than focal histologic abnormalities by light microscopy, heavy glomerular deposits of C4 and C3 by immunofluorescence and elevated serum creatinine concentrations.	Creatinine	233-243	complement C1q A chain	Homo sapiens	5-8
33722647-7	2021	Plasma concentrations of blood urea nitrogen (BUN) were significantly enhanced at 24 h, 72 h and 1 week, and creatinine (Cr) was increased at 24 h after reperfusion, which were changes reduced by EPO.	Creatinine	109-119	erythropoietin	Rattus norvegicus	196-199
33722647-7	2021	Plasma concentrations of blood urea nitrogen (BUN) were significantly enhanced at 24 h, 72 h and 1 week, and creatinine (Cr) was increased at 24 h after reperfusion, which were changes reduced by EPO.	Creatinine	121-123	erythropoietin	Rattus norvegicus	196-199
12104092-7	2002	Cystatin C detected reduced creatinine clearance with higher sensitivity of 92.9% (95% CI 80.5-98.4%) than serum creatinine, 71.4% (95% CI 55.4-84.3%).	Creatinine	28-38	cystatin C	Homo sapiens	0-10
12104092-9	2002	CONCLUSIONS: Serum cystatin C accurately reflects creatinine clearance over the entire range of transplant kidney function and is more efficacious than serum creatinine to detect reduced creatinine clearance in renal transplant recipients.	Creatinine	50-60	cystatin C	Homo sapiens	19-29
12138282-7	2002	The carriage rate of IL1RN*2 was significantly higher in IgAN patients with severe proteinuria (&gt;or=1.6 g/day) or increased serum creatinine level (&gt;or=2.0 mg/dl; p &lt; 0.05).	Creatinine	133-143	IGAN1	Homo sapiens	57-61
12032722-10	2002	Complications due to treatment included: duodenal ulcer in one patient that responded to medical treatment, and transient elevation in serum creatinine levels in three patients, which returned to normal after decrease in dosage or cessation of oral CSA.	Creatinine	141-151	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	249-252
11877571-5	2002	Twenty-four-hour creatinine clearance and 1/OCIF in predialysis patients showed a clear positive correlation and a straight line regression (1/OCIF = 0.443 + 0.004 x creatinine clearance; r2 = 0.425; P &lt; 0.0001).	Creatinine	17-27	TNF receptor superfamily member 11b	Homo sapiens	143-147
11877571-5	2002	Twenty-four-hour creatinine clearance and 1/OCIF in predialysis patients showed a clear positive correlation and a straight line regression (1/OCIF = 0.443 + 0.004 x creatinine clearance; r2 = 0.425; P &lt; 0.0001).	Creatinine	166-176	TNF receptor superfamily member 11b	Homo sapiens	44-48
11877571-5	2002	Twenty-four-hour creatinine clearance and 1/OCIF in predialysis patients showed a clear positive correlation and a straight line regression (1/OCIF = 0.443 + 0.004 x creatinine clearance; r2 = 0.425; P &lt; 0.0001).	Creatinine	166-176	TNF receptor superfamily member 11b	Homo sapiens	143-147
11750287-0	2002	Relationship between serum cystatin C and creatinine in kidney and liver transplant patients.	Creatinine	42-52	cystatin C	Homo sapiens	27-37
11750287-2	2002	In our study, the relationship between serum cystatin C and creatinine in kidney and liver transplant patients was investigated.	Creatinine	60-70	cystatin C	Homo sapiens	45-55
11750287-7	2002	The creatinine/cystatin C ratio in the liver transplant group is significantly lower than in the other group of patients (p&lt;0.001).	Creatinine	4-14	cystatin C	Homo sapiens	15-25
11750287-10	2002	CONCLUSIONS: In the groups of kidney disease and kidney transplant patients, as renal function decreases, there is an increase in the creatinine/cystatin C ratio.	Creatinine	134-144	cystatin C	Homo sapiens	145-155
11750287-11	2002	This may be due to the fact that, since creatinine is eliminated by glomerular filtration and tubular secretion, as renal function is impaired, its serum concentration increases to a greater extent than that of cystatin C, which is only eliminated by glomerular filtration.	Creatinine	40-50	cystatin C	Homo sapiens	211-221
11750287-12	2002	In the liver transplant patients, the creatinine/cystatin C ratio is lower than in the other groups.	Creatinine	38-48	cystatin C	Homo sapiens	49-59
11836143-4	2002	For children ages 6-17 years, urinary concentration of N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and albumin were positively associated with urinary cadmium, but these associations did not remain statistically significant after adjusting for urinary creatinine and other potential confounders.	Creatinine	277-287	O-GlcNAcase	Homo sapiens	55-86
33011888-8	2021	In the PET results, D/P creatinine in all patients decreased after the short-term PR, and accordingly the peritoneal ultrafiltration volume increased.	Creatinine	24-34	transmembrane protein 37	Homo sapiens	82-84
31702404-8	2021	Furthermore, Tbeta4 attenuated histologic injury caused by I/R (p &lt; 0.01) and diminished serum urea-creatinine levels (p &lt; 0.001).Conclusion: These results suggest that Tbeta4 has significant improving effects in ischemic acute kidney injury.	Creatinine	98-113	thymosin beta 4, X-linked	Rattus norvegicus	13-19
34051264-5	2021	Exo-srIkB treatment resulted in lower levels of serum blood urea nitrogen, creatinine, and neutrophil gelatinase-associated lipocalin in post-ischemic mice than in the Exo-Naive treatment group.	Creatinine	75-85	5'-3' exoribonuclease 1	Mus musculus	0-3
33933022-7	2021	Treatment with L-ca significantly reduced the serum BUN, creatinine, uric acid and MDA level and increased catalase, GPX and SOD compared to the MSG group.	Creatinine	57-67	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	15-19
33933135-9	2021	Serum asprosin was found to be positively related with disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid, ACR, calcium channel blockers, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy, but negatively related with glomerular filtration rate, metformin, and acarbose therapy.	Creatinine	119-129	fibrillin 1	Homo sapiens	6-14
33432415-6	2021	NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 +- 143.9 and 139.4 +- 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 +- 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 +- 44.96 ng/g creatinine.	Creatinine	126-136	secreted phosphoprotein 1	Homo sapiens	152-155
33504456-10	2021	Strong positive correlations existed for HE4 with both tHcy and creatinine.	Creatinine	64-74	WAP four-disulfide core domain 2	Homo sapiens	41-44
33296710-0	2021	European Journal of Pharmaceutical Sciences: PHASCI-D-20-01517R2Inhibitory effects of vandetanib on creatinine transport via renal organic cation transporter OCT2.	Creatinine	100-110	solute carrier family 22 member 2	Homo sapiens	158-162
33296710-6	2021	Vandetanib inhibited the uptake of creatinine mediated by hOCT2 in a dose-dependent manner.	Creatinine	35-45	solute carrier family 22 member 2	Homo sapiens	58-63
33296710-7	2021	The IC50 value for vandetanib inhibition of creatinine uptake by hOCT2 was 3.7 +- 1.0 muM (average +- SE of three separate experiments).	Creatinine	44-54	solute carrier family 22 member 2	Homo sapiens	65-70
33296710-10	2021	These results suggest that hOCT2 may play a crucial role in elevating the serum creatinine levels, as well as increasing the risk of renal impairment during vandetanib administration.	Creatinine	80-90	solute carrier family 22 member 2	Homo sapiens	27-32
33627489-7	2021	Retrospective study of 247 patients who were diagnosed with kidney damage receiving cyclosporine or cisplatin in combination with the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin showed significant (P < 0.001) improvement of kidney function, as well as reduction in creatinine and uric acid, markers of kidney damage.	Creatinine	284-294	solute carrier family 5 member 2	Homo sapiens	134-164
33627489-7	2021	Retrospective study of 247 patients who were diagnosed with kidney damage receiving cyclosporine or cisplatin in combination with the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin showed significant (P < 0.001) improvement of kidney function, as well as reduction in creatinine and uric acid, markers of kidney damage.	Creatinine	284-294	solute carrier family 5 member 2	Homo sapiens	166-171
33488671-6	2020	POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and -0.67, respectively), indicating that it is a co-hub gene.	Creatinine	71-81	periostin	Homo sapiens	0-5
33488671-10	2020	POSTN level in the kidney tissue of IgAN patients was positively correlated with creatinine level and negatively correlated with eGFR.	Creatinine	81-91	periostin	Homo sapiens	0-5
33121838-4	2021	In clinical trials designed to demonstrate the CVD safety of SGLT2 inhibitors in type 2 diabetes mellitus (T2DM), consistent reductions in risks for secondary kidney disease end points (albuminuria and a composite of serum creatinine doubling or 40% estimated glomerular filtration rate decline, kidney failure, or death), along with reductions in CVD events, were observed.	Creatinine	223-233	solute carrier family 5 member 2	Homo sapiens	61-66
33106255-4	2021	In clinical trials designed to demonstrate the CVD safety of SGLT2 inhibitors in type 2 diabetes mellitus (T2DM), consistent reductions in risks for secondary kidney disease end points (albuminuria and a composite of serum creatinine doubling or 40% estimated glomerular filtration rate decline, kidney failure, or death), along with reductions in CVD events, were observed.	Creatinine	223-233	solute carrier family 5 member 2	Homo sapiens	61-66
32662255-8	2020	A higher baseline level of A-FABP was associated with a greater risk of developing rapid renal function decline, independent of age, sex, duration of diabetes, body mass index, systolic blood pressure, history of cardiovascular disease, baseline eGFR, urine albumin creatinine ratio, total cholesterol, glycosylated hemoglobin, high-sensitivity C-reactive protein and use of thiazolidinedione, insulin, angiotensin-converting-enzyme inhibitors and angiotensin II-receptor blockers and statin (odds ratio, 3.10; 95% confidence interval, 1.53 to 6.29; P=0.002).	Creatinine	266-276	fatty acid binding protein 4	Homo sapiens	27-33
33256349-7	2020	After adjustment of age, the IGF-I/IGFBP-3 ratio was significantly negatively associated with blood pressure and free thyroxine and positively associated with weight, hemoglobin, creatinine, alanine transferase, fasting glucose, and thyroid stimulating hormone.	Creatinine	179-189	insulin like growth factor binding protein 3	Homo sapiens	35-42
32767013-5	2020	The co-administration of Vit E and CLO significantly ameliorated CP-induced elevations in serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1 beta (IL-1beta), and interleukin- 6 (IL-6).	Creatinine	96-106	vitrin	Rattus norvegicus	25-28
32767013-5	2020	The co-administration of Vit E and CLO significantly ameliorated CP-induced elevations in serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1 beta (IL-1beta), and interleukin- 6 (IL-6).	Creatinine	108-110	vitrin	Rattus norvegicus	25-28
33349207-8	2020	The intragraft granzyme B+ T cell count was positively correlated with serum creatinine and 24-hour urine proteinuria but negatively correlated with estimated glomerular filtration rate.	Creatinine	77-87	granzyme B	Homo sapiens	15-25
11836143-4	2002	For children ages 6-17 years, urinary concentration of N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and albumin were positively associated with urinary cadmium, but these associations did not remain statistically significant after adjusting for urinary creatinine and other potential confounders.	Creatinine	277-287	O-GlcNAcase	Homo sapiens	88-91
11836143-6	2002	The associations with NAG and AAP but not with albumin remained statistically significant after adjusting for creatinine and other potential confounders.	Creatinine	110-120	O-GlcNAcase	Homo sapiens	22-25
11836143-7	2002	We found a positive dose-effect relationship between levels of creatinine-adjusted urinary cadmium and NAG and AAP activity, and statistically significant differences in mean activity for these two enzymes between the highest (&gt; or =1.0 microg cadmium/g creatinine) and the lowest (&lt; or =0.25 microg cadmium/g creatinine) exposure groups.	Creatinine	63-73	O-GlcNAcase	Homo sapiens	103-106
31762365-6	2020	In a mouse model of renal ischemia/reperfusion injury, increased plasma creatinine, a kidney damage marker, and histological changes were effectively inhibited by intravenous administration of SNO-Ser-PAMAM.	Creatinine	72-82	snubnose	Mus musculus	193-196
11737607-6	2001	Glomerular CTGF mRNA correlated inversely with creatinine clearance.	Creatinine	47-57	cellular communication network factor 2	Homo sapiens	11-15
33037651-9	2020	Log creatinine, log intact parathyroid hormone and log product of total calcium and phosphorus were independent predictors of log fibroblast growth factor-23.	Creatinine	4-14	fibroblast growth factor 23	Canis lupus familiaris	130-157
11887932-4	2001	In 10 normal pregnant women, urinary Ang-(1-7) and Ang II increased throughout gestation, averaging 1499.8 +/- 310 and 224.4 +/- 58 pmol/g of creatinine, respectively (p &lt; 0.05) at wk 35 and falling during lactation to 394.0 +/- 95 and 65.7 +/- 20 pmol/ g of creatinine (p &lt; 0.05), respectively.	Creatinine	142-152	angiogenin	Homo sapiens	37-40
32556219-9	2020	Patients with creatinine levels below 1.5 mg/dl at onset benefitted more from IL-1 inhibition with regard to their kidney functions and acute phase reactants.	Creatinine	14-24	interleukin 1 alpha	Homo sapiens	78-82
33294072-8	2020	According to the correlation test in this research, KIM-1 results had a statistically significant association with creatinine, urea, aspartate aminotransferase and alanine aminotransferase levels in all control and study groups.	Creatinine	115-125	hepatitis A virus cellular receptor 1	Rattus norvegicus	52-57
33262071-7	2021	Lower muscle mass as estimated by serum creatinine concentration was associated with lower irisin concentration (-1.38% per mg/dL (95% confidence interval [CI]: -2.45, -0.21) and with a 0.72% decrease in irisin concentration (95% CI: -1.48, -0.04) from baseline to 12 months.	Creatinine	40-50	fibronectin type III domain containing 5	Homo sapiens	91-97
33262071-7	2021	Lower muscle mass as estimated by serum creatinine concentration was associated with lower irisin concentration (-1.38% per mg/dL (95% confidence interval [CI]: -2.45, -0.21) and with a 0.72% decrease in irisin concentration (95% CI: -1.48, -0.04) from baseline to 12 months.	Creatinine	40-50	fibronectin type III domain containing 5	Homo sapiens	204-210
33262071-11	2021	CONCLUSIONS: Lower serum creatinine (reflecting lower muscle mass) and higher serum IL-6 were associated with higher serum irisin concentrations.	Creatinine	25-35	fibronectin type III domain containing 5	Homo sapiens	123-129
33312427-14	2020	Negative correlation of miR-21 with serum creatinine (r = -0.2215, P = 0.0348) suggests renal function as a potential influencing factor in miR-21 biogenesis in blood.	Creatinine	42-52	microRNA 21	Homo sapiens	24-30
33312427-14	2020	Negative correlation of miR-21 with serum creatinine (r = -0.2215, P = 0.0348) suggests renal function as a potential influencing factor in miR-21 biogenesis in blood.	Creatinine	42-52	microRNA 21	Homo sapiens	140-146
11566167-7	2001	RESULTS: Pearson correlation analyses showed that correlation between serum cystatin C and 99mTc-DTPA clearance was r=-0.522, p=0.006, between serum creatinine and 99mTc-DTPA was r=-0.373, p=0.06.	Creatinine	149-159	cystatin C	Homo sapiens	76-86
11601685-1	2001	Human cystatin C is a low molecular weight protein which has been proposed as a better marker of glomerular filtration rate than creatinine.	Creatinine	129-139	cystatin C	Homo sapiens	6-16
12899332-3	2001	RESULTS: Circulating levels of TM, PAI-I and TM/Cr ratio increased with increasing severity of PIH.	Creatinine	48-50	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	95-98
11518789-2	2001	In a pilot study of 20 renal transplant recipients and a validation study of 36 renal transplant recipients, MRP8/14 serum levels were measured with an enzyme-linked immunosorbent assay for 28 d, associated with C-reactive protein and creatinine serum levels, and grouped according to biopsy-proven acute rejection.	Creatinine	235-245	S100 calcium binding protein A8	Homo sapiens	109-113
33244142-9	2020	During the follow-up period of 1.3 +- 1.1 years, patients in the highest tertile of galectin-1 were associated with a greater risk of MACE after adjustment for age, sex, comorbidities, co-medications, serum levels of hemoglobin, creatinine, hs-CRP, ejection fraction, SYNTAX scores, and revascularization modalities (adjusted hazard ratio 10.95, 95% confidence interval 2.29-52.47, p = 0.003).	Creatinine	229-239	galectin 1	Homo sapiens	84-94
33167541-6	2020	In urine samples, the limits of detection for tenofovir and creatinine were 4 microg mL-1 and 0.03 micromol mL-1, respectively.	Creatinine	60-70	L1 cell adhesion molecule	Mus musculus	85-89
33167541-6	2020	In urine samples, the limits of detection for tenofovir and creatinine were 4 microg mL-1 and 0.03 micromol mL-1, respectively.	Creatinine	60-70	L1 cell adhesion molecule	Mus musculus	108-112
33167541-7	2020	In plasma samples, the limits of detection were 0.15 microg mL-1 for tenofovir and 0.0003 micromol mL-1 for creatinine.	Creatinine	108-118	L1 cell adhesion molecule	Mus musculus	99-103
32554157-13	2020	TLR4 expression on intermediate monocytes correlated with vasoactive-inotropic score (rs = 0.642, p = 0.0017), duration of ventilation (rs = 0.485, p = 0.0259), highest serum creatinine (rs = 0.547, p = 0.0102), postsurgical transfusion (total volume per kg bodyweight) (rs = 0.469, p = 0.0321) and lowest mean arterial pressure (rs = -0.530, p = 0.0135).	Creatinine	175-185	toll like receptor 4	Homo sapiens	0-4
11450891-5	2001	Statistical analysis of our results showed that cystatin C levels were significantly correlated to creatinine and creatinine clearance levels.	Creatinine	99-109	cystatin C	Homo sapiens	48-58
11450891-5	2001	Statistical analysis of our results showed that cystatin C levels were significantly correlated to creatinine and creatinine clearance levels.	Creatinine	114-124	cystatin C	Homo sapiens	48-58
11450891-7	2001	Establishing cystatin C levels can be useful in cases in which it is not possible to determine creatinine clearance.	Creatinine	95-105	cystatin C	Homo sapiens	13-23
11304414-6	2001	However, platelet PKCbeta immunoreactivity in cytosol fraction was significantly higher in diabetic patients with normal serum creatinine (Cr) level than in diabetic patients with abnormal Cr level (Cr &gt; or =1.5 mg/dl) or in healthy subjects.	Creatinine	127-137	protein kinase C beta	Homo sapiens	18-25
11304414-6	2001	However, platelet PKCbeta immunoreactivity in cytosol fraction was significantly higher in diabetic patients with normal serum creatinine (Cr) level than in diabetic patients with abnormal Cr level (Cr &gt; or =1.5 mg/dl) or in healthy subjects.	Creatinine	139-141	protein kinase C beta	Homo sapiens	18-25
11304414-6	2001	However, platelet PKCbeta immunoreactivity in cytosol fraction was significantly higher in diabetic patients with normal serum creatinine (Cr) level than in diabetic patients with abnormal Cr level (Cr &gt; or =1.5 mg/dl) or in healthy subjects.	Creatinine	189-191	protein kinase C beta	Homo sapiens	18-25
11304414-6	2001	However, platelet PKCbeta immunoreactivity in cytosol fraction was significantly higher in diabetic patients with normal serum creatinine (Cr) level than in diabetic patients with abnormal Cr level (Cr &gt; or =1.5 mg/dl) or in healthy subjects.	Creatinine	189-191	protein kinase C beta	Homo sapiens	18-25
11304414-7	2001	Moreover, significant negative correlation between PKCbeta immunoreactivity in cytosol fraction of platelets and serum Cr level was found in diabetic patients (P &lt; 0.05).	Creatinine	119-121	protein kinase C beta	Homo sapiens	51-58
11499564-4	2001	METHODS: multicenter randomized controlled trial of 86 adult IgAN patients with serum creatinine &lt; or = 1.5 mg/ dL and moderate proteinuria.	Creatinine	86-96	IGAN1	Homo sapiens	61-65
11412632-5	2001	The presence of mAlb was positively correlated with age, systolic blood pressure,body mass index, waist-to-hip ratio, pulse pressure, HDL cholesterol,triglycerides, glycemia and serum creatinine.	Creatinine	184-194	albumin	Mus musculus	16-20
11388472-10	2001	As compared with the placebo group, urinary cross-linked N-teleopeptides of type-I collagen/creatinine and deoxypyridinoline/creatinine were significantly decreased in the MBP group (p &lt; 0.05), while no significant differences between the two groups were observed in serum osteocalcin and bone-specific alkaline phosphatase concentrations.	Creatinine	92-102	myelin basic protein	Homo sapiens	172-175
11388472-10	2001	As compared with the placebo group, urinary cross-linked N-teleopeptides of type-I collagen/creatinine and deoxypyridinoline/creatinine were significantly decreased in the MBP group (p &lt; 0.05), while no significant differences between the two groups were observed in serum osteocalcin and bone-specific alkaline phosphatase concentrations.	Creatinine	125-135	myelin basic protein	Homo sapiens	172-175
11269791-1	2001	BACKGROUND: Little is known about when the urinary excretion of a combination of N-acetyl-beta-D-glucosaminidase (NAG) and beta2-microglobulin (beta2MG) concentration [relative to creatinine (Cr)] reaches maximal values during uncomplicated normotensive pregnancy.	Creatinine	180-190	O-GlcNAcase	Homo sapiens	114-117
11269791-1	2001	BACKGROUND: Little is known about when the urinary excretion of a combination of N-acetyl-beta-D-glucosaminidase (NAG) and beta2-microglobulin (beta2MG) concentration [relative to creatinine (Cr)] reaches maximal values during uncomplicated normotensive pregnancy.	Creatinine	192-194	O-GlcNAcase	Homo sapiens	114-117
11316238-4	2001	PATIENTS AND METHODS: We retrospectively analyzed the effect of methylprednisolone (MP) pulse therapy in 8 IgAN patients with serum creatinine concentrations (sCr) 2.76 +/- 1.32 mg/dl (mean +/- SD).	Creatinine	132-142	IGAN1	Homo sapiens	107-111
32818222-7	2020	Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045).	Creatinine	15-17	C-C motif chemokine ligand 2	Homo sapiens	49-54
32818222-7	2020	Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045).	Creatinine	15-17	C-C motif chemokine ligand 2	Homo sapiens	55-60
32818222-10	2020	Urine hepcidin/Cr was negatively correlated with tubular phosphorus reabsorption and was positively correlated with urine NGAL/Cr (r = -0.418, p = 0.019; r = 0.682, p = 0.000; respectively).	Creatinine	15-17	hepcidin antimicrobial peptide	Homo sapiens	6-14
32818222-10	2020	Urine hepcidin/Cr was negatively correlated with tubular phosphorus reabsorption and was positively correlated with urine NGAL/Cr (r = -0.418, p = 0.019; r = 0.682, p = 0.000; respectively).	Creatinine	127-129	hepcidin antimicrobial peptide	Homo sapiens	6-14
28095222-8	2001	Blockade of AT1and/or ETA/B-receptors significantly reduced urinary protein excretion and plasma creatinine levels (p&lt;0.01) and substantially improved renal vascular histology (sclerotic index 1.78+-0.13, 1.57+-0.22 and 1.85+-0.15 respectively, p&lt;0.01, vs. L-NAME eight week) without altering the L-NAME-induced increase of systolic pressure.	Creatinine	97-107	angiotensin II receptor, type 1a	Rattus norvegicus	12-15
31197474-7	2020	beta-2 microglobulin may provide earlier information regarding fetal glomerular and tubular function and is also predictive of long-term serum creatinine.	Creatinine	143-153	beta-2-microglobulin	Homo sapiens	0-20
32588918-1	2020	BACKGROUND: The PLASMIC score is a rapid and inexpensive tool for predicting severe ADAMTS13 deficiency (activity <10%) in patients with suspected thrombotic thrombocytopenic purpura (TTP) by analyzing seven parameters (platelet count; combined hemolysis variable; absence of active neoplasia; absence of an organ or stem-cell transplant; mean corpuscular value; international normalized ratio; and serum creatinine).	Creatinine	405-415	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	84-92
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	98-108	secreted phosphoprotein 1	Homo sapiens	4-7
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	148-158	secreted phosphoprotein 1	Homo sapiens	4-7
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	148-158	secreted phosphoprotein 1	Homo sapiens	4-7
32610429-6	2020	In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (p < 0.0001) and pFL-OPN (p < 0.001) were observed.	Creatinine	44-54	secreted phosphoprotein 1	Homo sapiens	132-135
11471552-10	2001	AGE-R2 mRNA levels correlated with sAGE levels (r = .61, p &lt; .05), and with creatinine clearance (r = -.63, p &lt; .05).	Creatinine	79-89	protein kinase C substrate 80K-H	Homo sapiens	0-6
11239019-10	2001	RESULTS: Serum OPG prior to glucocorticoid therapy was positively and independently correlated with serum creatinine.	Creatinine	106-116	TNF receptor superfamily member 11b	Homo sapiens	15-18
11157380-5	2001	Compared with normal controls (n = 20), mean +/- SD of urinary OPN in IgAN patients was decreased significantly (21.4 +/- 6.2 versus 11.6 +/- 9.6 mg/g creatinine, P: &lt; 0.001).	Creatinine	151-161	IGAN1	Homo sapiens	70-74
11136171-10	2001	Serum cystatin C concentration is a better marker of renal dysfunction (ie, reduced GFR) than plasma creatinine concentration, at least in elderly subjects with plasma creatinine concentrations within the normal range.	Creatinine	168-178	cystatin C	Homo sapiens	6-16
11768321-3	2001	The serum HGF level is correlated with serum creatinine, and it has been suggested that glomerular and tubular diseases affect serum HGF differently.	Creatinine	45-55	hepatocyte growth factor	Homo sapiens	10-13
11196109-6	2000	We found that creatinine in plasma from two GAMT-deficient patients appeared normal when measured by the Jaffe method but was decreased when measured enzymatically or by HPLC.	Creatinine	14-24	guanidinoacetate N-methyltransferase	Homo sapiens	44-48
11003365-5	2000	RESULTS: Six months after transplantation systolic and diastolic 24-hr ABP correlated with serum creatinine (r=0.41, P=0.005 and r=0.37, P&lt;0.01, respectively) although CBP did not.	Creatinine	97-107	amine oxidase copper containing 1	Homo sapiens	71-74
10875254-8	2000	The greater increase in circulating levels of IL-6 in PTH-treated ovx mice was paralleled by a greater rise in bone resorption markers with the mean level of urine collagen cross-links in the PTH-treated ovx group being more than 2.5-fold higher than in the PTH-treated sham/ovx animals (236 vs. 88.5 microg/mmol creatinine, P &lt; 0.0001).	Creatinine	313-323	parathyroid hormone	Mus musculus	54-57
10875254-8	2000	The greater increase in circulating levels of IL-6 in PTH-treated ovx mice was paralleled by a greater rise in bone resorption markers with the mean level of urine collagen cross-links in the PTH-treated ovx group being more than 2.5-fold higher than in the PTH-treated sham/ovx animals (236 vs. 88.5 microg/mmol creatinine, P &lt; 0.0001).	Creatinine	313-323	parathyroid hormone	Mus musculus	192-195
10875254-8	2000	The greater increase in circulating levels of IL-6 in PTH-treated ovx mice was paralleled by a greater rise in bone resorption markers with the mean level of urine collagen cross-links in the PTH-treated ovx group being more than 2.5-fold higher than in the PTH-treated sham/ovx animals (236 vs. 88.5 microg/mmol creatinine, P &lt; 0.0001).	Creatinine	313-323	parathyroid hormone	Mus musculus	192-195
10886574-4	2000	Individuals with higher triglycerides and lower high-density lipoprotein (HDL) and HDL-2 cholesterol at baseline were at increased risk for a rise in creatinine after adjustment for race, gender, baseline age, diabetes, serum creatinine, systolic blood pressure, and antihypertensive medication use (all P trends &lt;/=0.02).	Creatinine	226-236	junctophilin 3	Homo sapiens	83-88
32539832-8	2020	Change in FABP4 level was independently associated with basal FABP4 level and changes in waist circumference and creatinine after adjustment of age, sex and the treatment group.	Creatinine	113-123	fatty acid binding protein 4	Homo sapiens	10-15
31591691-3	2020	Thus, the objective of this observational study was to determine the comparability of renal function equations to body surface area (BSA)-adjusted 8-h creatinine clearance (CrCl) in aSAH patients.	Creatinine	151-161	CRCL	Homo sapiens	173-177
10886574-4	2000	Individuals with higher triglycerides and lower high-density lipoprotein (HDL) and HDL-2 cholesterol at baseline were at increased risk for a rise in creatinine after adjustment for race, gender, baseline age, diabetes, serum creatinine, systolic blood pressure, and antihypertensive medication use (all P trends &lt;/=0.02).	Creatinine	150-160	junctophilin 3	Homo sapiens	83-88
10943597-7	2000	Elevated levels of UBC antigen were also found in patients with benign urologic disorders (median: 4.18 microg/g creatinine vs. 7.46 microg/g creatinine in cancer patients).	Creatinine	113-123	ubiquitin C	Homo sapiens	19-22
10943597-7	2000	Elevated levels of UBC antigen were also found in patients with benign urologic disorders (median: 4.18 microg/g creatinine vs. 7.46 microg/g creatinine in cancer patients).	Creatinine	142-152	ubiquitin C	Homo sapiens	19-22
10943597-8	2000	Using a cutoff of 14.06 microg/g creatinine (corresponding to 95% specificity in the group of healthy individuals), sensitivity of UBC antigen ranged between 21.6% (pTa) and 75% (pT4).	Creatinine	33-43	ubiquitin C	Homo sapiens	131-134
10773608-4	2000	Cystatin C detected reduced creatinine clearance with higher sensitivity (97 vs. 83%), and higher negative predictive value (96 vs. 87%) compared to creatinine.	Creatinine	28-38	cystatin C	Homo sapiens	0-10
10773608-7	2000	Serum cystatin C is as efficacious as serum creatinine to detect reduced GFR as measured by creatinine clearance.	Creatinine	92-102	cystatin C	Homo sapiens	6-16
10652026-10	2000	Quantitative analysis found that increased glomerular and tubular MIF expression gave a highly significant correlation with macrophage and T-cell accumulation, the severity of histologic lesions, and the loss of creatinine clearance.	Creatinine	212-222	macrophage migration inhibitory factor	Homo sapiens	66-69
32317005-4	2020	RESULTS: Our study showed a favorable effect on HbA1c concentration and a slightly unfavorable effect on serum creatinine concentration in users of the five DPP-4 inhibitors, a favorable effect on lipid metabolism in sitagliptin, vildagliptin, and alogliptin users, and a favorable effect on hepatic parameters in sitagliptin, alogliptin, and linagliptin users, in comparison of the baseline and exposure periods.	Creatinine	111-121	dipeptidyl peptidase 4	Homo sapiens	157-162
32334458-9	2020	The upper levels of miR-19a were significantly correlated with the increased serum levels of CK-MB (rho=0.29, P<0.0001), CTn I (rho=0.4, P<0.0001) and creatinine (rho=0.27, P<0.0001).	Creatinine	151-161	microRNA 19a	Homo sapiens	20-27
31837940-13	2020	Treatment with PD-1/PD-L1 inhibitors should be prescribed with caution in patients with UC and creatinine above 1.2 mg/dL.	Creatinine	95-105	CD274 molecule	Homo sapiens	20-25
31879775-10	2020	Urine albumin concentrations and albumin-to-creatinine ratios were 200% lower in rats fed LF-enriched diets than in COs (P < 0.05).	Creatinine	44-54	lactotransferrin	Rattus norvegicus	90-92
31606236-9	2020	RESULTS: High levels (>3.9mug/g of creatinine) of urinary MMP-7 were associated with a 2.7-fold higher risk for IgAN progression in adjusted analyses.	Creatinine	35-45	matrix metallopeptidase 7	Homo sapiens	58-63
31911503-4	2020	Worsening renal function (WRF) was defined as a decrease of &gt;20% in creatinine clearance (CrCl) from baseline.	Creatinine	71-81	CRCL	Homo sapiens	93-97
31778243-7	2020	Furthermore, miR-21 expression was negatively correlated with serum creatinine, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-17, while positively correlated with albumin in sepsis patients.	Creatinine	68-78	microRNA 21	Homo sapiens	13-19
32092895-5	2020	Creatinine similarly increased in the hot environment PreHA (0.35 +- 0.23 mg dL-1) and PostHA (0.39 +- 0.20 mg dL-1), with greater increases than the mild environment at both time points (0.11 +- 0.07 mg dL-1, 0.08 +- 0.06 mg dL-1, p <= 0.001), respectively.	Creatinine	0-10	l(1)L1	Drosophila melanogaster	77-81
32092895-5	2020	Creatinine similarly increased in the hot environment PreHA (0.35 +- 0.23 mg dL-1) and PostHA (0.39 +- 0.20 mg dL-1), with greater increases than the mild environment at both time points (0.11 +- 0.07 mg dL-1, 0.08 +- 0.06 mg dL-1, p <= 0.001), respectively.	Creatinine	0-10	l(1)L1	Drosophila melanogaster	111-115
32092895-5	2020	Creatinine similarly increased in the hot environment PreHA (0.35 +- 0.23 mg dL-1) and PostHA (0.39 +- 0.20 mg dL-1), with greater increases than the mild environment at both time points (0.11 +- 0.07 mg dL-1, 0.08 +- 0.06 mg dL-1, p <= 0.001), respectively.	Creatinine	0-10	l(1)L1	Drosophila melanogaster	111-115
32092895-5	2020	Creatinine similarly increased in the hot environment PreHA (0.35 +- 0.23 mg dL-1) and PostHA (0.39 +- 0.20 mg dL-1), with greater increases than the mild environment at both time points (0.11 +- 0.07 mg dL-1, 0.08 +- 0.06 mg dL-1, p <= 0.001), respectively.	Creatinine	0-10	l(1)L1	Drosophila melanogaster	111-115
32092939-10	2020	MiR-21 correlated significantly with serum concentration of creatinine (r = 0.52, p = 0.003) and eGFR (r = -0.45; p = 0.01).	Creatinine	60-70	microRNA 21	Homo sapiens	0-6
10627439-3	2000	Serum syndecan-1 correlated with the following: serum creatinine, secretion of urine M-component over the course of 24 hours, soluble interleukin-6 (IL-6) receptor, C-terminal telopeptide of type I collagen, beta(2)-microglobulin, percentage of plasma cells in the bone marrow, disease stage, and serum M-component concentration.	Creatinine	54-64	syndecan 1	Homo sapiens	6-16
31866449-5	2020	Serum creatine kinase (CK) activity, cholesterol, and creatinine levels showed a marked significant (P &lt; 0.05) increase in all GAA supplemented groups compared to the control one.	Creatinine	54-64	lysosomal alpha-glucosidase	Oreochromis niloticus	130-133
31912323-4	2020	The combined erythropoietin and sesame oil treatment significantly reduced BUN, ALT, creatinine, lipid peroxidation, ROS, and proinflammatory markers and GSH and antioxidant enzyme levels.	Creatinine	85-95	erythropoietin	Rattus norvegicus	13-27
11204865-5	2000	In addition, the constant serum concentration of cystatin C means it has possible application as a replacement for creatinine in the measurement of glomerular filtration rate.	Creatinine	115-125	cystatin C	Homo sapiens	49-59
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-C motif chemokine ligand 2	Homo sapiens	117-122
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-C motif chemokine ligand 2	Homo sapiens	123-127
31744381-5	2020	The method yielded suitable levels of specificity and selectivity, and calibration curves of creatine and creatinine in serum were linear over the concentration range of 0.5-200 microg mL-1.	Creatinine	106-116	L1 cell adhesion molecule	Mus musculus	185-189
10901178-8	2000	Obese aged ZDFxSHHF have marked renal hypertrophy, a 3-8 fold decrease in creatinine clearance (compared with SHHF, SHR and WKY), a high percent of segmental + global glomerulosclerosis (59.8%+/-10.8), and severe tubulointerstitial and vascular changes.	Creatinine	74-84	leptin	Rattus norvegicus	0-5
10959481-4	2000	Cystatin C detected reduced creatinine clearance with the high sensitivity of 95%.	Creatinine	28-38	cystatin C	Homo sapiens	0-10
10959481-6	2000	We demonstrated a strong correlation and linear association between 1/cystatin C and creatinine clearance over the entire range of transplant function, equivalent to that of 1/creatinine.	Creatinine	85-95	cystatin C	Homo sapiens	70-80
10959481-7	2000	In summary, serum cystatin C accurately reflects creatinine clearance over the entire range of transplant function and is as efficacious as serum creatinine to detect reduced creatinine clearance in renal transplant recipients.	Creatinine	49-59	cystatin C	Homo sapiens	18-28
10585359-6	1999	Plasma cystatin C correlated with plasma creatinine (r = 0.741; P &lt;0.0001) and the reciprocal of the creatinine clearance estimated by the Cockcroft-Gault formula (r = 0.882; P &lt;0.001).	Creatinine	41-51	cystatin C	Homo sapiens	7-17
10585359-6	1999	Plasma cystatin C correlated with plasma creatinine (r = 0.741; P &lt;0.0001) and the reciprocal of the creatinine clearance estimated by the Cockcroft-Gault formula (r = 0.882; P &lt;0.001).	Creatinine	104-114	cystatin C	Homo sapiens	7-17
10604644-6	1999	RESULTS: In patients with type 2 diabetes the correlation coefficient between plasma cystatin C and the plasma clearance of 51Cr-EDTA was 0.774 (Spearman"s coefficient) and that between plasma creatinine and the plasma clearance of 51Cr-EDTA was 0.556 (p = 0.001 for the difference).	Creatinine	193-203	cystatin C	Homo sapiens	85-95
10587838-5	1999	In contrast, in patients with microalbuminuria, significantly raised plasma Lp(a) levels were observed only when creatinine clearance rates or plasma creatinine levels indicated pathological kidney function.	Creatinine	113-123	lipoprotein(a)	Homo sapiens	76-81
10587838-5	1999	In contrast, in patients with microalbuminuria, significantly raised plasma Lp(a) levels were observed only when creatinine clearance rates or plasma creatinine levels indicated pathological kidney function.	Creatinine	150-160	lipoprotein(a)	Homo sapiens	76-81
10587838-7	1999	CONCLUSIONS: In microalbuminuria and apparently in normoalbuminuria, altered kidney function determined by creatinine clearance rates or creatinine levels appears to be a major determinant of raised Lp(a) levels in both type 1 and type 2 diabetic patients.	Creatinine	107-117	lipoprotein(a)	Homo sapiens	199-204
10587838-7	1999	CONCLUSIONS: In microalbuminuria and apparently in normoalbuminuria, altered kidney function determined by creatinine clearance rates or creatinine levels appears to be a major determinant of raised Lp(a) levels in both type 1 and type 2 diabetic patients.	Creatinine	137-147	lipoprotein(a)	Homo sapiens	199-204
10327141-13	1999	A trend was observed, hyperglycosylated hCG MoM values decreasing with advancing creatinine concentration (1.77, 1.08, 1.01, 0.73 and 0.60 at 0.25, 0.50, 0.79, 1.11 and 1.73 mg/ml, respectively).	Creatinine	81-91	hypertrichosis 2 (generalised, congenital)	Homo sapiens	40-43
10370741-5	1999	The mean renal dipeptidase activities in urine were 2.56, 2.46 and 0.78 U/mol creatinine for healthy subjects, patients with diabetes and patients with chronic renal failure, respectively.	Creatinine	78-88	dipeptidase 1	Homo sapiens	9-26
9760814-13	1998	MCP-1 levels were particularly high (&gt; 2000 pg/mg creatinine) in patients with enhanced dynamics of ch.g.r.	Creatinine	53-63	C-C motif chemokine ligand 2	Homo sapiens	0-5
32299081-11	2020	In comparison with the C0 group, the C1/C2 group had higher proportions of patients with hypertension (p = 0.04), haematuria (p = 0.03), worse serum creatinine (p = 0.0007), and worse estimated glomerular filtration rate (p = 0.0007).	Creatinine	149-159	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	37-42
31694915-5	2019	Panx1 knockout mice subjected to renal IRI had decreased plasma creatinine, malondialdehyde (MDA) levels in kidney tissues, and tubular cell death (visible as decreased TUNEL-positive renal tubular cells) compared with WT mice.	Creatinine	64-74	pannexin 1	Mus musculus	0-5
31841203-13	2019	The levels of creatinine and blood urea nitrogen in LPS + CRNDE siRNA group were notably lower than those of the LPS group (p&lt;0.05).	Creatinine	14-24	colorectal neoplasia differentially expressed (non-protein coding)	Mus musculus	58-63
31700042-4	2019	The median level of hepcidin was significantly lower (p = 0.002) after recovery (7.7 [6.2-13.0] ng/mL) than that before treatment (17.4 [7.6-20.4] ng/mL), while creatinine (p = 0.011) and GFR (p &lt; 0.001) significantly improved after euthyroidism was achieved.	Creatinine	161-171	hepcidin antimicrobial peptide	Homo sapiens	20-28
31772941-7	2019	The increase in ANGPTL4 correlated with clinical parameters of DN including albumin-to-creatinine ratio (r = 0.271, P = 0.002), serum creatinine (r = 0.381, P = 0.0001), and eGFR (r = -0.349, P < 0.0001).	Creatinine	87-97	angiopoietin like 4	Homo sapiens	16-23
31772941-7	2019	The increase in ANGPTL4 correlated with clinical parameters of DN including albumin-to-creatinine ratio (r = 0.271, P = 0.002), serum creatinine (r = 0.381, P = 0.0001), and eGFR (r = -0.349, P < 0.0001).	Creatinine	134-144	angiopoietin like 4	Homo sapiens	16-23
31772941-12	2019	The elevation in ANGPTL4 correlated significantly with clinical markers of DN such as ACR, serum creatinine, and eGFR, as well as IGFBP1 and IGFBP4.	Creatinine	97-107	angiopoietin like 4	Homo sapiens	17-24
31591331-8	2019	Interestingly, a higher affinity of hOCT2 Ala270Ser for creatinine was observed.	Creatinine	56-66	solute carrier family 22 member 2	Homo sapiens	36-41
31506585-6	2019	SGLT2 inhibitors significantly lowered urine albumin-to-creatinine ratio (UACR) (WMD, -14.64 mg/g; 95% CI, -25.15 to -4.12; P = 0.006) compared with controls.	Creatinine	56-66	solute carrier family 5 member 2	Homo sapiens	0-5
31430074-14	2019	Serum creatinine concentrations were significantly higher in the WT+Tm (p < 0.05) and BDNF(+/-)+Tm (p < 0.05) groups.	Creatinine	6-16	brain derived neurotrophic factor	Mus musculus	86-90
31377226-9	2019	AQP5 was inversely correlated with eGFR slope (Pearson"s r = -0.12, p &lt; 0.001), and independent of clinical risk factors age, sex, race, and baseline systolic and diastolic blood pressure, hemoglobin A1c, total cholesterol, eGFR, and urine albumin-to-creatinine ratio (beta = -0.05, p &lt; 0.004).	Creatinine	254-264	aquaporin 5	Homo sapiens	0-4
31103655-8	2019	The geometric mean (GM) concentration of beta2M in the total population was 1.88 mug/g creatinine (95% confidence interval (CI) 1.85-1.91).	Creatinine	87-97	beta-2-microglobulin	Homo sapiens	41-47
31583027-3	2019	We also tried to identify potential association of HE4 levels with other conditions such as smoking, age, BMI, and creatinine levels.	Creatinine	115-125	WAP four-disulfide core domain 2	Homo sapiens	51-54
30756411-8	2019	The rate constant for urinary excretion (k10 ) was slightly reduced by the preceding surgery, by a marked rise in plasma albumin, and by a high preinfusion urinary concentration of creatinine.	Creatinine	181-191	keratin 10	Homo sapiens	41-44
31232037-0	2019	Accuracy of Urinary Epidermal Growth Factor to Creatinine Ratio to Predict 24-Hour Urine Epidermal Growth Factor and Interstitial Kidney Fibrosis in Patients with IgA Nephropathy.	Creatinine	47-57	epidermal growth factor	Homo sapiens	89-112
31232037-11	2019	Spot EGF/creatinine ratios overestimated the 24-hours EGF at low excretion values and underestimated it at high excretion values.	Creatinine	9-19	epidermal growth factor	Homo sapiens	54-57
29846359-10	2019	Conversely, EPO pretreatment injected 60 min before RI was associated with lower BUN and Cr levels compared with RI (P < 0.001 and P = 0.003, respectively) and RI + rIC (P < 0.001 and P = 0.001, respectively).	Creatinine	89-91	erythropoietin	Rattus norvegicus	12-15
29890853-6	2019	Depletion of Numb from proximal tubules (PT-Nb-KO) exacerbated AKI shown as more severe renal tubular damage and higher serum creatinine than wild-type mice.	Creatinine	126-136	NUMB endocytic adaptor protein	Mus musculus	13-17
30576085-7	2019	There were significant decreases in urinary beta-2-microglobulin to creatinine and retinol-binding protein to creatinine ratios by week 12 (P < 0.01 for both).	Creatinine	68-78	beta-2-microglobulin	Homo sapiens	44-64
31459817-1	2019	We have recently reported that hydride (H-) doped superatom (HPd@Au8)+ protected by eight PPh3 ligands selectively grew into (HPd@Au10)3+ by the nucleophilic addition of two Au(I)Cl units.	Creatinine	31-38	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
32734188-5	2019	On admission, serum creatinine level was elevated with increased urinary beta2-microglobulin and N-acetyl-beta-d-glucosaminidase excretion.	Creatinine	20-30	beta-2-microglobulin	Homo sapiens	73-92
30302966-5	2019	Univariate analyses revealed significant correlations of soluble DPP-4 levels with the total cholesterol (r=0.214, P=0.019) and serum creatinine levels (r=-0.315, P<0.001) and the estimated glomerular filtration rate (eGFR; estimated using the modification of diet in renal disease equation) (r=0.303, P=0.001).	Creatinine	134-144	dipeptidyl peptidase 4	Homo sapiens	65-70
30302966-6	2019	The associations of soluble DPP-4 levels with serum creatinine and GFR remained significant after adjusting for age, body mass index, and duration of diabetes.	Creatinine	52-62	dipeptidyl peptidase 4	Homo sapiens	28-33
30774748-5	2019	Chronic DPP4 inhibition positively affected renal function with a significant reduction in albuminuria and serum creatinine.	Creatinine	113-123	dipeptidyl peptidase 4	Homo sapiens	8-12
9760814-14	1998	The MCP-1 levels were higher in those patients whose biopsies described cellular infiltration (1385 + 820 pg/mg creatinine vs 680 + 280 pg/mg creatinine).	Creatinine	112-122	C-C motif chemokine ligand 2	Homo sapiens	4-9
9760814-14	1998	The MCP-1 levels were higher in those patients whose biopsies described cellular infiltration (1385 + 820 pg/mg creatinine vs 680 + 280 pg/mg creatinine).	Creatinine	142-152	C-C motif chemokine ligand 2	Homo sapiens	4-9
9760814-15	1998	The urine level of MCP-1 showed a correlation with concentration of serum creatinine, cholesterol, level of proteinuria and with arterial pressure in ch.g.r.	Creatinine	74-84	C-C motif chemokine ligand 2	Homo sapiens	19-24
9587785-9	1998	Similarly, the enhanced blood urea nitrogen and serum creatinine levels which are indicative of renal injury showed a reduction of about 50% at a higher dose of Vit.E.	Creatinine	54-64	vitrin	Rattus norvegicus	161-164
31166462-5	2019	RESULTS: Cr was higher (p = 0.0053) in RDS (0.82 +- 0.04) than in the others (RDAT 0.55 +- 0.04; HS 0.55 +- 0.04).	Creatinine	9-11	peripherin 2	Rattus norvegicus	39-42
30303710-11	2019	Furthermore, albuminuria can positively predict the serum SOD3 level for the ratio of urinary albumin to urinary creatinine (ACR) >1,190.769 mg/g and the urinary SOD3 level for ACR >=300 mg/g.	Creatinine	113-123	acrosin	Homo sapiens	125-128
30284913-5	2019	The effect on albumin-creatinine ratio was independent of age or stage of estimated glomerular filtration; however, there was a significant negative correlation between albumin-creatinine ratio at the initiation of SGLT2 inhibitor and change in ACR.	Creatinine	177-187	solute carrier family 5 member 2	Homo sapiens	215-220
30284913-5	2019	The effect on albumin-creatinine ratio was independent of age or stage of estimated glomerular filtration; however, there was a significant negative correlation between albumin-creatinine ratio at the initiation of SGLT2 inhibitor and change in ACR.	Creatinine	177-187	acrosin	Homo sapiens	245-248
30284913-6	2019	Multiple linear regression analysis identified use of empagliflozin, beta-blockers, and sulphonylureas, Deltasystolic blood pressure at office, serum Cr and albumin-creatinine ratio value at initiation of SGLT2 inhibitor as independent and significant determinants of change in ACR.	Creatinine	165-175	solute carrier family 5 member 2	Homo sapiens	205-210
30716739-3	2019	OBJECTIVE: To determine the impact of eGFR and creatinine clearance (CrCl) on long-term all-cause mortality following acute PE in association with other routine laboratory analyses and comorbidities.	Creatinine	47-57	CRCL	Homo sapiens	69-73
30735719-5	2019	Moreover, serum DMP1 concentrations were closely related to blood urea nitrogen, creatinine, cystatin C, and vascular endothelial growth factor (VEGF).	Creatinine	81-91	dentin matrix acidic phosphoprotein 1	Homo sapiens	16-20
30486327-7	2018	The area under the curve (AUC) value for ERFD prediction was significantly improved when the HCR biomarker was included in the model with albumin to creatinine ratio (ACR) and baseline characteristics (AUC values were 0.803 and 0.759 for HCR and ACR, respectively; p value was 0.0423 for difference between models).	Creatinine	149-159	coiled-coil alpha-helical rod protein 1	Homo sapiens	93-96
30401390-3	2018	The aims of this cohort study were to describe the changes in HTx recipients" serum creatinine and estimated glomerular filtration rate (eGFR) levels 5 years following HTx in Taiwan.	Creatinine	84-94	Zic family member 3	Homo sapiens	62-65
30401390-9	2018	CONCLUSION: As renal function deteriorates after HTx, we observed a steep decline in serum creatinine level and glomerular filtration rate within the 3 months after HTx, followed by a slow rate of deterioration over the following months.	Creatinine	91-101	Zic family member 3	Homo sapiens	49-52
30401390-9	2018	CONCLUSION: As renal function deteriorates after HTx, we observed a steep decline in serum creatinine level and glomerular filtration rate within the 3 months after HTx, followed by a slow rate of deterioration over the following months.	Creatinine	91-101	Zic family member 3	Homo sapiens	165-168
30127967-5	2018	The results revealed that patients in the high PKM2 group (&gt;=11.25) exhibited significantly lower creatinine levels (P=0.043), higher fetoprotein levels (P&lt;0.001), advanced stage (P&lt;0.001) and higher grade (P=0.004) compared with patients with low PKM2 expression levels (&lt;11.25).	Creatinine	101-111	pyruvate kinase M1/2	Homo sapiens	47-51
29575276-2	2018	The use of HE4 and Risk of Ovarian Malignancy Algorithm (ROMA) is recommended as a tool for selective ovarian cancer screening; however, creatinine is a known confounder.	Creatinine	137-147	WAP four-disulfide core domain 2	Homo sapiens	11-14
29575276-7	2018	RESULTS: Creatinine correlated with HE4 (women: r = .864, P &lt; .0001; men: r = .848, P &lt; .0001).	Creatinine	9-19	WAP four-disulfide core domain 2	Homo sapiens	36-39
29575276-9	2018	HE4 in women after Tx (median of 84.8 pmol/L) was significantly higher than non-Tx women (53.7 pmol/L, P &lt; .0001) in the reference range of serum creatinine.	Creatinine	149-159	WAP four-disulfide core domain 2	Homo sapiens	0-3
29575276-11	2018	CONCLUSION: Human epididymis protein 4 (HE4) was significantly increased in women after solid organ transplantation compared to levels without transplants matched by age and serum creatinine.	Creatinine	180-190	WAP four-disulfide core domain 2	Homo sapiens	40-43
9553787-7	1998	RESULTS: Inhalation exposure to 2-methoxyethylacetate at 0.5 cm3/m3 corresponded to MAA excretion of 3 mmol/mol creatinine in urine at 14 to 16 hours after exposure.	Creatinine	112-122	MAA	Homo sapiens	84-87
28303680-9	2018	Correlation analyses revealed that A-FABP concentrations were correlated with body mass index (BMI), diastolic blood pressure, urinary microalbumin, and serum creatinine in male patients, and with BMI, duration of T2DM, fasting blood glucose, and serum creatinine in female patients.	Creatinine	159-169	fatty acid binding protein 4	Homo sapiens	35-41
28303680-9	2018	Correlation analyses revealed that A-FABP concentrations were correlated with body mass index (BMI), diastolic blood pressure, urinary microalbumin, and serum creatinine in male patients, and with BMI, duration of T2DM, fasting blood glucose, and serum creatinine in female patients.	Creatinine	253-263	fatty acid binding protein 4	Homo sapiens	35-41
29482993-9	2018	SGLT2 inhibition relative to placebo was associated with preservation in serum creatinine levels or initial increases followed by return to baseline levels in patients with renal impairment, but levels were preserved in patients without renal impairment.	Creatinine	79-89	solute carrier family 5 member 2	Homo sapiens	0-5
29861470-6	2018	RESULTS: Serum Mg2+ and urinary EGF/creatinine were significantly lower in the CNI treated children, with significantly more CNI-treated children developing hypomagnesaemia.	Creatinine	36-46	epidermal growth factor	Homo sapiens	32-35
29146035-2	2018	The present review summarizes the current knowledge of the effects of DPP-4is on renal outcomes by analyzing the experimental preclinical data, the effects of DPP-4is on urinary albumin-creatinine ratios (UACRs) and estimated glomerular filtration rates (eGFRs) from observational studies and clinical trials, and renal events (including kidney failure requiring renal replacement therapy) in recent large prospective cardiovascular outcome trials.	Creatinine	186-196	dipeptidyl peptidase 4	Homo sapiens	159-164
9553787-14	1998	CONCLUSION: According to these results, it seems that the BAL for MAA and EAA should be 3 and 50 mmol/mol creatinine as measured at 14-16 h after exposure, respectively.	Creatinine	106-116	MAA	Homo sapiens	66-69
9500578-2	1998	We compared the TM level with urinary albumin excretion (UAE), creatinine (Cr) clearance, and indices of renal tubular damage such as urinary beta2-microglobulin.	Creatinine	63-73	thrombomodulin	Homo sapiens	16-18
29241623-5	2018	In IL-36R knockout mice, plasma creatinine, blood urea nitrogen, and IL-6 levels after ischemia-reperfusion injury were significantly lower than those in wild-type mice.	Creatinine	32-42	interleukin 1 receptor-like 2	Mus musculus	3-9
29386545-8	2018	The performance of creatinine-adjusted HJV was also superior to NGAL in predicting advanced AKI (AUC = 0.784 and 0.694; p = 0.037) and composite outcome (AUC = 0.842 and 0.676; p = 0.002).	Creatinine	19-29	hemojuvelin BMP co-receptor	Homo sapiens	39-42
29441948-8	2018	Renal cells with upregulated miR-146 had lower plasma levels of blood urea nitrogen (BUN) and creatinine, decreased apoptosis and active caspase-3 protein expressions.	Creatinine	94-104	microRNA 146	Mus musculus	29-36
30048993-7	2018	RESULTS: The results showed that the serum ELA levels decreased gradually with the deterioration of DKD from the stages of normal albuminuria, microalbuminuria, macroalbuminuria, to macroalbuminuria and elevated serum creatinine.	Creatinine	218-228	apelin receptor early endogenous ligand	Homo sapiens	43-46
29122892-7	2018	RESULTS: Urinary creatinine-corrected NGAL (uNGALcc, ng/mg) was significantly elevated at V1 in DM+PE+ vs. DM+PE- women (P = 0.01); this remained significant after exclusion of leukocyte-positive samples (5 DM+PE+ and 2 DM+PE-) (P = 0.02).	Creatinine	17-27	nibrin	Homo sapiens	87-92
9500578-2	1998	We compared the TM level with urinary albumin excretion (UAE), creatinine (Cr) clearance, and indices of renal tubular damage such as urinary beta2-microglobulin.	Creatinine	75-77	thrombomodulin	Homo sapiens	16-18
10682482-6	1998	(2) There were significant correlations between EGF level and Ams, Cr levels in amniotic fluid.	Creatinine	67-69	epidermal growth factor	Homo sapiens	48-51
9090444-5	1997	The mean value for urinary GGT was found to be 0.77 +/- 0.05 U/mg creatinine (n = 16) in the control group.	Creatinine	66-76	gamma-glutamyltransferase 1	Rattus norvegicus	27-30
28963073-15	2017	MiR-146a silencing also abrogated the MVs-induced decrease in serum creatinine, reduction of immature DCs phenotype in transplant and increase in miR-146a expression level.	Creatinine	68-78	microRNA 146	Mus musculus	0-8
28596160-5	2017	Both total urinary angiotensinogen/creatinine ratio and intact urinary angiotensinogen/creatinine ratio tended to decrease after administration of SGLT2 inhibitors.	Creatinine	87-97	solute carrier family 5 member 2	Homo sapiens	147-152
9921405-6	1997	Age, blood urea nitrogen, and creatinine were positively correlated and creatinine clearance was inversely correlated with the serum level of thrombomodulin.	Creatinine	72-82	thrombomodulin	Homo sapiens	142-156
28795637-8	2017	ANGPTL-4 showed significant positive correlation with serum creatinine ( r = 0.304, p = 0.056) and body mass index (BMI) ( r = 0.424, p = 0.009) in CSA patients.	Creatinine	60-70	angiopoietin like 4	Homo sapiens	0-8
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	93-103	beta-2-microglobulin	Homo sapiens	34-54
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	129-139	beta-2-microglobulin	Homo sapiens	34-54
28979155-6	2017	In addition, serum cystatin-C and beta-2 microglobulin were positively correlated with urea, creatinine, serum ferritin, albumin/creatinine ratio, duration of chelation therapy and frequency of blood transfusion/year and negatively correlated with creatinine clearance, hemoglobin, and eGFR.	Creatinine	129-139	beta-2-microglobulin	Homo sapiens	34-54
9812765-2	1997	The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P &lt; 0.05) and reached the lowest level on the third day (P &lt; 0.01).	Creatinine	85-95	epidermal growth factor	Homo sapiens	102-105
28455659-6	2017	Concentration of miR-21 ( Ct value) in plasma was negatively correlated with creatinine (r = -0.432, p = 0.028) and positively correlated with eGFR (r = 0.423, p = 0.031).	Creatinine	77-87	microRNA 21	Homo sapiens	17-23
28266128-3	2017	Knockout of PHD2 in EC up-regulated the expression of HIF-1alpha and HIF-2alpha, resulting in a significant decline of renal function as evidenced by elevated levels of serum creatinine.	Creatinine	175-185	egl-9 family hypoxia-inducible factor 1	Mus musculus	12-16
9812765-2	1997	The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P &lt; 0.05) and reached the lowest level on the third day (P &lt; 0.01).	Creatinine	85-95	epidermal growth factor	Homo sapiens	102-105
9812765-2	1997	The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P &lt; 0.05) and reached the lowest level on the third day (P &lt; 0.01).	Creatinine	97-99	epidermal growth factor	Homo sapiens	70-73
9812765-2	1997	The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P &lt; 0.05) and reached the lowest level on the third day (P &lt; 0.01).	Creatinine	97-99	epidermal growth factor	Homo sapiens	102-105
9812765-2	1997	The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P &lt; 0.05) and reached the lowest level on the third day (P &lt; 0.01).	Creatinine	97-99	epidermal growth factor	Homo sapiens	102-105
8948523-2	1996	Compared with rats administered vehicle, rats administered ulinastatin (150,000 U/kg body weight) intravenously 30 min preischemia had significantly lower serum creatinine and blood urea nitrogen, and much less injury evident by examination of kidney histologies over the course of 48 h postreperfusion.	Creatinine	161-171	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	59-70
8885120-2	1996	However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobramycin clearance because of a lack of correlation.	Creatinine	61-71	CRCL	Homo sapiens	83-87
8704105-6	1996	Steady-state 24-h urinary excretion of AQP-2 was 43 +/- 10 nmol/24 h (or 28.5 +/- 6.9 pmol/mg creatinine), and 20 +/- 6 nmol/24 h (or 18.3 +/- 7.9 pmol/mg creatinine) in men and women, respectively.	Creatinine	94-104	aquaporin 2	Homo sapiens	39-44
31089516-8	2017	Results: Serum DPP-4 concentration was positively correlated with lean body mass, total cholesterol level, and creatinine level.	Creatinine	111-121	dipeptidyl peptidase 4	Homo sapiens	15-20
8704105-6	1996	Steady-state 24-h urinary excretion of AQP-2 was 43 +/- 10 nmol/24 h (or 28.5 +/- 6.9 pmol/mg creatinine), and 20 +/- 6 nmol/24 h (or 18.3 +/- 7.9 pmol/mg creatinine) in men and women, respectively.	Creatinine	155-165	aquaporin 2	Homo sapiens	39-44
8785447-4	1996	The plasma concentration of immunoreactive guanylin in the normal individuals tested was 30.3 +/- 3.7 fmol/ml (mean +/- SE) and that in patients with chronic renal failure was elevated with increasing serum creatinine concentration.	Creatinine	207-217	guanylate cyclase activator 2A	Homo sapiens	43-51
28731262-4	2017	We observed that pretreatment with GFA attenuated cisplatin-induced elevations in blood urea nitrogen and creatinine levels and histopathological injury induced by cisplatin.	Creatinine	106-116	glutamine fructose-6-phosphate transaminase 1	Mus musculus	35-38
8640042-2	1996	The median standardized IL-1 alpha creatinine quotient in children with first-time acute pyelonephritis was 3.6 pg/mumol, but was nondetectable in children with recurrent pyelonephritis, children with non-renal febrile conditions and children convalescent after acute pyelonephritis (p &lt; 0.05-0.01).	Creatinine	35-45	interleukin 1 alpha	Homo sapiens	24-34
28645189-6	2017	RARalpha displayed a renoprotective role in GS rats, resulting in a lower GS index, podocyte foot process fusion, and proteinuria, reduced serum creatinine and blood urea nitrogen.	Creatinine	145-155	retinoic acid receptor, alpha	Rattus norvegicus	0-8
8640042-6	1996	The acute IL-1 alpha creatinine quotients were lowest in children with uptake defects on 99mTC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection (reflecting the acute inflammation) (p &lt; 0.001) and 1 year after the acute infection (reflecting permanent kidney scarring) (p &lt; 0.001).	Creatinine	21-31	interleukin 1 alpha	Homo sapiens	10-20
8865868-7	1996	The mass transfer coefficient of creatinine scaled by BSA (MTCcr/BSA) was a positive predictor of delta D PAI/BSA, suggesting the diffusion of plasma PAI-1 into the peritoneal cavity also accounted for part of the increased dialysate PAI-1 levels during PET.	Creatinine	33-43	serpin family E member 1	Homo sapiens	150-155
28325783-4	2017	RESULTS: With chronic (4 weeks) sodium-glucose cotransporter 2 inhibition, baseline fractional glucose excretion (&lt;2%) rose to 38 +- 12% and 46 +- 11% (fasting vs. postmeal, respectively; P &lt; 0.0001) over a range of BMIs (range 23-41 kg/m2) and creatinine clearance (65-168 mL   min-1   m-2).	Creatinine	251-261	solute carrier family 5 member 2	Homo sapiens	32-62
8865868-7	1996	The mass transfer coefficient of creatinine scaled by BSA (MTCcr/BSA) was a positive predictor of delta D PAI/BSA, suggesting the diffusion of plasma PAI-1 into the peritoneal cavity also accounted for part of the increased dialysate PAI-1 levels during PET.	Creatinine	33-43	serpin family E member 1	Homo sapiens	234-239
8791046-10	1996	Intergroup comparison showed significantly (p &lt; or = 0.004) high urinary PSA (mean level +/- SEM 28.3 +/- 3.4 micrograms/mmol creatinine) only in the benign prostatic hyperplasia group, mean levels in the prostate carcinoma, prostatitis and control groups being 3.7 +/- 1.1, 11 +/- 2.9 and 5.2 +/- 0.9 micrograms/mmol creatinine, respectively.	Creatinine	129-139	kallikrein related peptidase 3	Homo sapiens	76-79
8791046-10	1996	Intergroup comparison showed significantly (p &lt; or = 0.004) high urinary PSA (mean level +/- SEM 28.3 +/- 3.4 micrograms/mmol creatinine) only in the benign prostatic hyperplasia group, mean levels in the prostate carcinoma, prostatitis and control groups being 3.7 +/- 1.1, 11 +/- 2.9 and 5.2 +/- 0.9 micrograms/mmol creatinine, respectively.	Creatinine	321-331	kallikrein related peptidase 3	Homo sapiens	76-79
8731497-7	1996	The increase of soluble TM in sera paralleled levels of urinary albumin, blood urea nitrogen (BUN), s-creatinine (Cr), and duration of noninsulin-dependent diabetes mellitus (NIDDM).	Creatinine	102-112	thrombomodulin	Homo sapiens	24-26
8731497-7	1996	The increase of soluble TM in sera paralleled levels of urinary albumin, blood urea nitrogen (BUN), s-creatinine (Cr), and duration of noninsulin-dependent diabetes mellitus (NIDDM).	Creatinine	114-116	thrombomodulin	Homo sapiens	24-26
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Creatinine	261-271	interferon gamma	Rattus norvegicus	80-105
8586009-5	1995	In the enalapril group, EGF excretion progressively increased from 188 to 214 nmol/mmol creatinine after 6 weeks and to 274 after 8 months of therapy (P = 0.03).	Creatinine	88-98	epidermal growth factor	Homo sapiens	24-27
7540432-4	1995	However, IGF-1 significantly enhanced functional and histologic recovery in the survivors, as measured by serum creatinine and creatinine clearance and by histologic scoring.	Creatinine	112-122	insulin-like growth factor 1	Rattus norvegicus	9-14
7540432-4	1995	However, IGF-1 significantly enhanced functional and histologic recovery in the survivors, as measured by serum creatinine and creatinine clearance and by histologic scoring.	Creatinine	127-137	insulin-like growth factor 1	Rattus norvegicus	9-14
7785966-3	1995	In the first case, a high myoglobin clearance at admission (27 mL/min) was accompanied by normal serum creatinine and creatinine clearances.	Creatinine	103-113	myoglobin	Homo sapiens	26-35
7785966-3	1995	In the first case, a high myoglobin clearance at admission (27 mL/min) was accompanied by normal serum creatinine and creatinine clearances.	Creatinine	118-128	myoglobin	Homo sapiens	26-35
7942810-6	1994	Serum levels of creatinine and urea nitrogen showed significant negative correlations with EGF, but not with ET and cAMP.	Creatinine	16-26	epidermal growth factor	Homo sapiens	91-94
7532065-6	1994	A significant correlation was found between the serum creatinine level and the beta-2 microglobulin level (r = 0.849) in patients with renal dysfunction.	Creatinine	54-64	beta-2-microglobulin	Homo sapiens	79-99
7851853-9	1994	These findings suggest that: a) in cirrhotics with normal serum creatinine the average serum gastrin levels over the course of the day are indeed higher than in normals and b) In cirrhotics with hepatorenal syndrome, impaired urinary gastrin output appears to contribute significantly to their hypergastrinemia.	Creatinine	64-74	gastrin	Homo sapiens	93-100
28224182-12	2017	In addition, PARP inhibition increased creatinine clearance in diabetic animals and reduced renal TGF-beta1 and glomerular fibrosis.	Creatinine	39-49	poly (ADP-ribose) polymerase 1	Rattus norvegicus	13-17
28340405-5	2017	The covariates included age, sex, body surface area, bodyweight, height and creatinine clearance (CRCL).	Creatinine	76-86	CRCL	Homo sapiens	98-102
28617168-11	2017	CONCLUSION: Renalase strongly and inversely correlated with kidney function, positively with creatinine and lipid disturbances.	Creatinine	93-103	renalase, FAD dependent amine oxidase	Homo sapiens	12-20
7807707-10	1994	The cutoff points of 0.800 mg/g creatinine of urinary 3-Hyp for persons under 65 years of age and 0.600 mg/g creatinine for persons 65 years or older were the best thresholds for cancer screening.	Creatinine	32-42	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	56-59
7941190-9	1994	EGF concentrations were significantly reduced in patients with TCC compared with controls either when uncorrected (p &lt; 0.0001) or corrected (p &lt; 0.000000002) for urinary creatinine excretion.	Creatinine	176-186	epidermal growth factor	Homo sapiens	0-3
8009810-4	1994	Intravenous injection of recombinant human interleukin-1 alpha (r. HuIL-1 alpha: 0.5 microgram/kg) caused shivering, fever, inhibition of rumen contractions, tachycardia, hypoferraemia, hypozincaemia, hyperglycaemia followed by hypoglycaemia, changes in plasma urea and creatinine values, lymphopaenia and neutropaenia followed by neutrophilic leukocytosis.	Creatinine	270-280	interleukin 1 alpha	Homo sapiens	43-62
7515265-9	1994	Factors associated with G-CSF elevation were fever, neutropenia, pathogen type and raised bilirubin and creatinine.	Creatinine	104-114	colony stimulating factor 3	Homo sapiens	24-29
8124953-12	1994	A renal elimination mechanism for IL-1ra was suggested by the positive correlation between IL-1ra plasma clearance and estimated creatinine clearance (p = .001; r2 = .51).	Creatinine	129-139	interleukin 1 receptor antagonist	Homo sapiens	34-40
28539288-4	2017	Pearson correlation analysis was used to test the correlations of miR-29a and miR-10a-5p with serum creatinine (Scr), cystatin C (Cys-C), and KIM-1 in patients with AKI.	Creatinine	100-110	microRNA 29a	Homo sapiens	66-73
28343425-5	2017	Expert opinion: In addition to the aim of improving lipid profile with fibrates, the interest in new PPAR-alpha activators stems from the need to overcome some of the clinical problems encountered with dose-dependent adverse events; a rise of plasma creatinine, gallstone formation, drug-drug interactions (i.e. gemfibrozil), and myopathy.	Creatinine	250-260	peroxisome proliferator activated receptor alpha	Homo sapiens	101-111
27645611-10	2017	The AHRs for the highest tertile group in death or dialysis, CVEs, and MIA syndrome were 25.91 and 65.84 and 152.50(all Ps &lt;0.05).The AUROC for B2M in death or dialysis, CVEs, and MIA syndrome were greater than that for creatinine.	Creatinine	223-233	beta-2-microglobulin	Homo sapiens	147-150
28419560-13	2017	Serum creatinine and phosphorus concentrations were the strongest independent predictors of FGF-23 concentration.	Creatinine	6-16	fibroblast growth factor 23	Canis lupus familiaris	92-98
7999416-17	1994	The half-dose rIL-2 regimen was significantly less toxic in terms of hypotension (P = 0.014), fever (P = 0.014), oliguria (P = 0.042), serum creatinine elevation (P = 0.009) and prothrombin time elongation (P = 0.038).	Creatinine	141-151	interleukin 2	Rattus norvegicus	14-19
31994099-5	2017	The covariates included age, sex, body surface area, bodyweight, height and creatinine clearance (CRCL).	Creatinine	76-86	CRCL	Homo sapiens	98-102
28294194-4	2017	PDE5i treatment prevented the development of DN-related hypertension (P &lt; 0.001), the increase of urine albumin creatinine ratio (P &lt; 0.01), the fall in glomerular filtration rate (P &lt; 0.001), and improved renal resistive index (P &lt; 0.001) and kidney microcirculation.	Creatinine	115-125	phosphodiesterase 5A, cGMP-specific	Mus musculus	0-4
28321056-6	2017	The urinary albumin/creatinine ratio (U-ACR) was significantly reduced in the patients whose U-ACR levels were 30-300 mg/gCr at the baseline.	Creatinine	20-30	acrosin	Homo sapiens	40-43
28321056-6	2017	The urinary albumin/creatinine ratio (U-ACR) was significantly reduced in the patients whose U-ACR levels were 30-300 mg/gCr at the baseline.	Creatinine	20-30	acrosin	Homo sapiens	95-98
27550472-8	2017	Vit E successfully lowered serum levels of urea and creatinine, enhanced creatinine clearance and diuresis, and normalized relative kidney/body weight.	Creatinine	52-62	vitrin	Rattus norvegicus	0-3
27550472-8	2017	Vit E successfully lowered serum levels of urea and creatinine, enhanced creatinine clearance and diuresis, and normalized relative kidney/body weight.	Creatinine	73-83	vitrin	Rattus norvegicus	0-3
27224553-7	2017	In a multivariable model, we identified creatinine, NT-proBNP, galectin-3, high-sensitive troponin T, and smoking as factors associated with HE4.	Creatinine	40-50	WAP four-disulfide core domain 2	Homo sapiens	141-144
27906636-9	2016	In the absence of allopurinol, plasma creatinine levels of some Urat1-Uox-DKO mice were higher than those of Uox-KO mice.	Creatinine	38-48	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	64-69
27882940-8	2016	Doxycycline-induced deletion of MDM2 in tubular cell-specific MDM2-knockout mice Pax8rtTa-cre; MDM2f/f caused acute kidney injury with increased plasma creatinine and blood urea nitrogen and sharp decline of glomerular filtration rate.	Creatinine	152-162	transformed mouse 3T3 cell double minute 2	Mus musculus	32-36
27882940-8	2016	Doxycycline-induced deletion of MDM2 in tubular cell-specific MDM2-knockout mice Pax8rtTa-cre; MDM2f/f caused acute kidney injury with increased plasma creatinine and blood urea nitrogen and sharp decline of glomerular filtration rate.	Creatinine	152-162	transformed mouse 3T3 cell double minute 2	Mus musculus	62-66
27861629-8	2016	RESULTS: The RHI and ABI values and the serum level of creatinine were found to be significantly correlated with the TM level (P = 0.040, 0.041 and 0.005, respectively).	Creatinine	55-65	thrombomodulin	Homo sapiens	117-119
27582100-8	2016	A specific IKK2 inhibitor, KINK-1, reduced BUN and serum creatinine compared with nontreated mice after IRI induction, but the frequency of kidney Th17 cells was also significantly increased.	Creatinine	57-67	inhibitor of kappaB kinase beta	Mus musculus	11-15
27605629-8	2016	The creatinine increases were accompanied by a rise in the levels of urinary renal damage markers [beta-2-microglobulin (B2M), total protein, kidney injury molecule (KIM1), alpha-glutathione S-transferase (aGST), N-acetyl-beta-(d)-glucosaminidase (NAG)].	Creatinine	4-14	beta-2-microglobulin	Homo sapiens	99-119
27605629-8	2016	The creatinine increases were accompanied by a rise in the levels of urinary renal damage markers [beta-2-microglobulin (B2M), total protein, kidney injury molecule (KIM1), alpha-glutathione S-transferase (aGST), N-acetyl-beta-(d)-glucosaminidase (NAG)].	Creatinine	4-14	beta-2-microglobulin	Homo sapiens	121-124
7684745-7	1993	Unlike uIGFs, urinary concentrations of IGFBP-3 (uIGFBP-3; nanograms per milligram creatinine) were age-, but not sex-related.	Creatinine	83-93	insulin like growth factor binding protein 3	Homo sapiens	40-47
8170811-9	1993	Negative correlation between blood serum beta 2-microglobulin levels and creatinine clearance was shown.	Creatinine	73-83	beta-2-microglobulin	Homo sapiens	41-61
28760225-10	2016	A randomised clinical trial of an SGLT2 inhibitor in patients with DM2 and underlying cardiovascular disease showed that its use in association with standard therapy slowed the progression of renal damage and reduced significant renal events such as doubling of serum creatinine values and initiation of dialysis.	Creatinine	268-278	solute carrier family 5 member 2	Homo sapiens	34-39
26440731-5	2016	At multivariate analysis estimated creatinine clearance, protease inhibitors co-administration and SLC28A2 CT/TT genotypes were independently associated with plasma tenofovir exposure; ABCC10 GA/AA genotypes and protease inhibitor co-administration were independently associated with the urinary to plasma tenofovir ratio.	Creatinine	35-45	ATP binding cassette subfamily C member 10	Homo sapiens	185-191
26609908-11	2016	(4) Urinary MCP-1 and TGF-1 concentrations were positively correlated with serum creatinine and decreased in the SG group.	Creatinine	81-91	C-C motif chemokine ligand 2	Homo sapiens	12-17
27489301-1	2016	BACKGROUND AND OBJECTIVES: Overestimation of GFR by urinary creatinine clearance (CrCl) at lower levels of GFR has long been attributed to enhanced creatinine secretion.	Creatinine	60-70	CRCL	Homo sapiens	82-86
27489301-1	2016	BACKGROUND AND OBJECTIVES: Overestimation of GFR by urinary creatinine clearance (CrCl) at lower levels of GFR has long been attributed to enhanced creatinine secretion.	Creatinine	148-158	CRCL	Homo sapiens	82-86
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 22 member 2	Homo sapiens	118-146
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 22 member 2	Homo sapiens	148-152
8097382-7	1993	In the pre-DOCA experiments, ANF infusions at 15, 30, and 100 ng.kg-1.min-1 produced dose-related increases in urinary sodium excretion and significant elevations in creatinine clearance.	Creatinine	166-176	natriuretic peptide A	Canis lupus familiaris	29-32
27316632-2	2016	As lowering HbA1c, SBP, weight and intraglomerular pressure is associated with anti-albuminuric effects in diabetes, we hypothesised that SGLT2 inhibition would reduce the urine albumin-to-creatinine ratio (UACR) to a clinically meaningful extent.	Creatinine	189-199	solute carrier family 5 member 2	Homo sapiens	138-143
27402391-2	2016	The recommended dose of the dipeptidyl peptidase-4 inhibitor saxagliptin is 2.5 mg in patients with moderate or severe renal impairment (creatinine clearance &lt;=50 mL/min).	Creatinine	137-147	dipeptidyl peptidase 4	Homo sapiens	28-50
27604800-8	2016	Among the podocyte proteins, urine synaptopodin showed strong correlation with serum creatinine by multivariate regression analysis (p &lt; 0.001) and showed linear correlation (r = 0.429, p &lt; 0.01).	Creatinine	85-95	synaptopodin	Homo sapiens	35-47
27604800-11	2016	CONCLUSIONS: Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion.	Creatinine	57-67	synaptopodin	Homo sapiens	19-31
27416751-11	2016	Renalase was positively correlated with serum creatinine and dialysis vintage (r = 0.677, p &lt; 0.001 and r = 0.625, p &lt; 0.001, respectively).	Creatinine	46-56	renalase, FAD dependent amine oxidase	Homo sapiens	0-8
27416751-14	2016	The main parameters affecting renalase levels are dialysis vintage and serum creatinine.	Creatinine	77-87	renalase, FAD dependent amine oxidase	Homo sapiens	30-38
27292126-4	2016	Overexpression of miR-10a alleviated the increased ratio of urine albumin-to-creatinine (ACR) ratio of HFD/STZ mice.	Creatinine	77-87	microRNA 10a	Mus musculus	18-25
27548845-5	2016	CCL2/CXCL10 are reported in relation to urine creatinine (ng/mmol).	Creatinine	46-56	C-C motif chemokine ligand 2	Homo sapiens	0-4
27335376-3	2016	After renal I/R, PAD4 wild-type mice develop severe AKI with large increases in plasma creatinine, neutrophil infiltration, as well as significant renal tubular necrosis, apoptosis, and proinflammatory cytokine generation.	Creatinine	87-97	peptidyl arginine deiminase 4	Homo sapiens	17-21
1614390-3	1992	On the other hand, fractional excretion of BMG (FE-BMG; BMG clearance/creatinine clearance) slowly elevated after operation and reached a peak on the 2nd postoperative day.	Creatinine	70-80	beta-2-microglobulin	Homo sapiens	43-46
27368064-10	2016	In the non-sarcopenia population, ASM/HT(2) presents as renal function risk factor, which perhaps associated with higher muscle mass to induce a greater underestimation for creatinine and urinary albumin.	Creatinine	173-183	H19 imprinted maternally expressed transcript	Homo sapiens	34-37
27317647-9	2016	Renal IL-10 level increased while serum creatinine decreased significantly in IL-10 group at 12 weeks compared to PBS or YFP controls.	Creatinine	40-50	interleukin 10	Rattus norvegicus	78-83
26960759-6	2016	Egr1 (-/-) mice were protected from renal failure, reflected by low levels of serum urea and creatinine.	Creatinine	93-103	early growth response 1	Mus musculus	0-4
1347859-2	1992	Urinary PAF concentrations, measured by radioimmunoassay, were significantly higher in acute-phase HUS patients than in controls (mean 2.04 [SD 1.66] vs 0.72 [0.43] ng/mg creatinine, p less than 0.05) but were similar to those in controls in samples taken after recovery.	Creatinine	171-181	PCNA clamp associated factor	Homo sapiens	8-11
1436286-2	1992	There was a significant correlation between plasma levels of C4a and plasma creatinine and urea.	Creatinine	76-86	complement C4A (Rodgers blood group)	Homo sapiens	61-64
26342005-7	2016	Mean urinary glycolate, glycerate and 4-hydroxy-2-oxoglutarate or 2,4-dihydroxyglutarate (expressed as a ratio to creatinine) were significantly higher in patients with PH1, PH2 and PH3, respectively.	Creatinine	114-124	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	169-172
1509636-3	1992	EGF levels were expressed as urinary EGF/creatinine ratios, and a highly significant decrease (alpha = 0.0005 by Student"s t-test) of urinary EGF was found in the patient group prior to surgery.	Creatinine	41-51	epidermal growth factor	Homo sapiens	0-3
1531561-2	1992	Intermittent NPB was without effect on urine flow and urinary sodium excretion but caused a significant increase in creatinine clearance.	Creatinine	116-126	neuropeptide B	Homo sapiens	13-16
2047946-2	1991	The results showed median values for serum B2m in patients with MM, MGUS and the control group to be 8.10 mg/l, 3.05 mg/l, and 2.35 mg/l, respectively; these values differed significantly from one another (P less than 0.01), even when patients with normal renal function (serum creatinine value less than 110 mumol/l) were considered separately.	Creatinine	278-288	beta-2-microglobulin	Homo sapiens	43-46
2047946-5	1991	In the 43 MM patients serum B2m concentrations had a significant positive correlation with serum creatinine (r = 0.706; P less than 0.005) and a significant negative correlation with haemoglobin values (r = -0.459; P = 0.006).	Creatinine	97-107	beta-2-microglobulin	Homo sapiens	28-31
1868919-6	1991	Urinary concentrations of hEGF in normal males and females were 30.2 +/- 13.0 ng/mg creatinine and 46.4 +/- 17.4 ng/mg creatinine, respectively.	Creatinine	84-94	epidermal growth factor	Homo sapiens	26-30
1868919-6	1991	Urinary concentrations of hEGF in normal males and females were 30.2 +/- 13.0 ng/mg creatinine and 46.4 +/- 17.4 ng/mg creatinine, respectively.	Creatinine	119-129	epidermal growth factor	Homo sapiens	26-30
2042015-8	1991	Intestinal calbindin-D9K correlated inversely with plasma creatinine (p less than 0.05), but the mean level of calbindin-D9K was unchanged in this model of moderate chronic uraemia.	Creatinine	58-68	S100 calcium binding protein G	Rattus norvegicus	11-24
1799191-3	1991	The glomerular filtration rate was similar in psoriatics as compared with age- and sex-matched controls, whereas urinary EGF (microgram/g creatinine) was significantly reduced in psoriatics: normotensive subjects, 29.52 +/- 3.51 (psoriatics) versus 44.31 +/- 1.20 (controls, p less than 0.05); hypertensive subjects, 19.67 +/- 3.96 (psoriatics) versus 30.11 +/- 1.52 (controls, p less than 0.05).	Creatinine	138-148	epidermal growth factor	Homo sapiens	121-124
27321309-5	2016	RESULTS: Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and HbA1c showed that serum DPP-4 levels were positively associated with visceral fat area (beta=0.25, p=0.04), but not subcutaneous fat area (beta=-0.18, p=0.13).	Creatinine	97-107	dipeptidyl peptidase 4	Homo sapiens	137-142
26198473-5	2016	The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, gamma-glutamyl transpeptidase, and alanine transaminase (P&lt; .001).	Creatinine	101-111	CIMT	Homo sapiens	4-8
26351173-5	2016	Alpha 2 macroglobulin could differentiate children with SRNS-focal segmental glomerulosclerosis (FSGS) from SRNS-minimal change disease (MCD) at values &gt;3.3 microg/mg of creatinine [AUC 0.84 (CI 0.62-1.0), 90 % sensitivity and 85 % specificity].	Creatinine	173-183	alpha-2-macroglobulin	Homo sapiens	0-21
26821795-5	2016	RESULTS: Participants in the highest quartile of DPP4 activity had higher HbA1c, homeostatic model assessment of insulin resistance, nitrotyrosine, 8-iso-PGF2a, interleukin-6, high-sensitivity C-reactive protein, mannose 6-phosphate receptor, urinary albumin-to-creatinine ratio and lower estimated glomerular filtration rate compared with participants in the lowest quartile (all p &lt; 0.001).	Creatinine	262-272	dipeptidyl peptidase 4	Homo sapiens	49-53
26821795-6	2016	DPP4 activities were associated positively with HbA1c, homeostatic model assessment of insulin resistance, nitrotyrosine, 8-iso-PGF2a, interleukin-6, high-sensitivity C-reactive protein, mannose 6-phosphate receptor, urinary albumin-to-creatinine ratio and negatively with estimated glomerular filtration rate (all p &lt; 0.001).	Creatinine	236-246	dipeptidyl peptidase 4	Homo sapiens	0-4
1785943-3	1991	It is known that the urinary EGF content corrected for the creatinine value correlates very well with the EGF level in blood as well as in 24-h urine specimens.	Creatinine	59-69	epidermal growth factor	Homo sapiens	106-109
1944722-1	1991	The ratios creatinine clearance (Crcl)/inulin clearance (INcl) obtained in 523 measurements and reported in 14 papers have been analyzed and the values of CRcl corresponding to those of INcl have been evaluated.	Creatinine	11-21	CRCL	Homo sapiens	33-37
1944746-3	1991	It appeared that elevated plasma C3d concentrations were present in patients with plasma creatinine concentrations in excess of 200 mumol/l regardless of the type of kidney disease.	Creatinine	89-99	endogenous retrovirus group K member 13	Homo sapiens	33-36
2006396-1	1991	The purpose of this prospective study was to evaluate beta-2-microglobulin (beta 2m) as a differential diagnostic indicator between hepatic nephropathy (HN) and acute tubulointerstitial nephropathy (ATIN) in patients with reduced renal function and hepatic coma, and to determine whether beta 2m excretion could be used as a marker of renal impairment before increased serum creatinine (S-Cr) concentration or decreased creatinine clearance (Cr-Cl).	Creatinine	375-385	beta-2-microglobulin	Homo sapiens	54-74
2006396-1	1991	The purpose of this prospective study was to evaluate beta-2-microglobulin (beta 2m) as a differential diagnostic indicator between hepatic nephropathy (HN) and acute tubulointerstitial nephropathy (ATIN) in patients with reduced renal function and hepatic coma, and to determine whether beta 2m excretion could be used as a marker of renal impairment before increased serum creatinine (S-Cr) concentration or decreased creatinine clearance (Cr-Cl).	Creatinine	375-385	beta-2-microglobulin	Homo sapiens	76-83
2006396-1	1991	The purpose of this prospective study was to evaluate beta-2-microglobulin (beta 2m) as a differential diagnostic indicator between hepatic nephropathy (HN) and acute tubulointerstitial nephropathy (ATIN) in patients with reduced renal function and hepatic coma, and to determine whether beta 2m excretion could be used as a marker of renal impairment before increased serum creatinine (S-Cr) concentration or decreased creatinine clearance (Cr-Cl).	Creatinine	420-430	beta-2-microglobulin	Homo sapiens	54-74
2006396-1	1991	The purpose of this prospective study was to evaluate beta-2-microglobulin (beta 2m) as a differential diagnostic indicator between hepatic nephropathy (HN) and acute tubulointerstitial nephropathy (ATIN) in patients with reduced renal function and hepatic coma, and to determine whether beta 2m excretion could be used as a marker of renal impairment before increased serum creatinine (S-Cr) concentration or decreased creatinine clearance (Cr-Cl).	Creatinine	420-430	beta-2-microglobulin	Homo sapiens	76-83
1978880-5	1990	The GM-CSF group had lower haemoglobin concentrations and platelet counts and higher plasma urea, creatinine, and bilirubin than the placebo group.	Creatinine	98-108	colony stimulating factor 2	Homo sapiens	4-10
1698438-5	1990	Coefficients of log-transformed data with creatinine-derived glomerular filtration rate (GFR) were -0.87 for B2M, -0.71 for RBP, and -0.62 for A1M.	Creatinine	42-52	beta-2-microglobulin	Homo sapiens	109-112
2305532-4	1990	In this group only 2 patients had elevations in the serum creatinine level above 1.6 mg/dL-1.9 mg/dL and 2.4 mg/dL, respectively.	Creatinine	58-68	l(1)9	Drosophila melanogaster	88-94
2220342-3	1990	Urinary EGF concentrations were higher near mid-gestation (53.9 +/- 30.8 micrograms EGF/g creatinine) than near term (33.4 +/- 14.1 micrograms EGF/g creatinine) (p less than 0.006).	Creatinine	90-100	epidermal growth factor	Homo sapiens	8-11
2220342-3	1990	Urinary EGF concentrations were higher near mid-gestation (53.9 +/- 30.8 micrograms EGF/g creatinine) than near term (33.4 +/- 14.1 micrograms EGF/g creatinine) (p less than 0.006).	Creatinine	149-159	epidermal growth factor	Homo sapiens	8-11
2334495-5	1990	Also, alcohol increased creatinine clearance only in CBL mice.	Creatinine	24-34	Casitas B-lineage lymphoma	Mus musculus	53-56
32612933-5	2020	After starting ERT serial urine globotriaosylceramide (Gb3) measurements showed an upward trend from 333 to 2260 mug/mmol creatinine for patient 1 and 1165 to 2260 mug/mmol creatinine for patient 2.	Creatinine	122-132	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	55-58
32612933-5	2020	After starting ERT serial urine globotriaosylceramide (Gb3) measurements showed an upward trend from 333 to 2260 mug/mmol creatinine for patient 1 and 1165 to 2260 mug/mmol creatinine for patient 2.	Creatinine	173-183	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	55-58
32079027-8	2020	Irisin concentrations were significantly correlated with age (r=-0.44; p &lt;0.001), creatinine (r=-0.35; p &lt;0.05), and fibrinogen (r=0.40; p &lt;0.05) concentrations.	Creatinine	85-95	fibronectin type III domain containing 5	Homo sapiens	0-6
34633852-6	2022	In the non-RRT patients, the median creatinine clearance (CrCL) was 75 mL/min and the mean daily dose of vancomycin was 25.5 mg/kg.	Creatinine	36-46	CRCL	Homo sapiens	58-62
34176389-6	2021	RESULTS: The TREM-1/TREM-2 ratio was decreased in CKD patients and correlated with serum creatinine, estimated glomerular filtration rate and cystatin c.	Creatinine	89-99	triggering receptor expressed on myeloid cells 1	Homo sapiens	13-19
34900377-10	2021	Elevated serum AST levels were also associated with increased serum creatinine kinase (CK) levels, suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and CPS.	Creatinine	68-78	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	15-18
34564871-4	2022	Creatinine clearance (CrCL) was identified as a covariate on CL/F, and body weight as a covariate on CL/F, apparent central volume of distribution, and apparent intercompartmental clearance.	Creatinine	0-10	CRCL	Homo sapiens	22-26
34496965-7	2021	At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independently associated to resistin levels at stepwise regression analysis.	Creatinine	175-185	resistin	Homo sapiens	23-31
34496965-7	2021	At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independently associated to resistin levels at stepwise regression analysis.	Creatinine	203-213	resistin	Homo sapiens	23-31
34114140-7	2021	Moreover, the expression of CD38 was proportionally correlated with the levels of Cr, UA, and urea in serum.	Creatinine	82-84	CD38 molecule	Homo sapiens	28-32
34121556-17	2021	The injection of anti-MPO IgG induced a significant elevation of Serum creatinine and blood urea nitrogen in serum, as well as urine blood, urine protein and urine leukocytes.	Creatinine	71-81	myeloperoxidase	Rattus norvegicus	22-25
34184429-13	2021	Enhanced creatinine was found after a single intravenous injection of PS or R15 (900 U kg-1 , body weight), suggesting possible abnormal renal function.	Creatinine	9-19	ribonuclease A family member 2	Rattus norvegicus	76-91
34474819-6	2021	The experiments revealed that PEG membranes can give a better solute rejection percentage (93%) but with a low creatinine adsorption capacity that is 7654 mug/g and low bio-compatibility (PRT 392 s, HR 0.46%).	Creatinine	111-121	progestagen associated endometrial protein	Homo sapiens	30-33
34474819-7	2021	However, PEG/CA membranes give maximum creatinine adsorption that is 9643 mug/g and also better bio-compatibility (PRT 490 s, HR 0.37%) but with a low BSA rejection (72%) as compared to the pristine PSU and PEG membranes.	Creatinine	39-49	progestagen associated endometrial protein	Homo sapiens	9-12
34564090-1	2021	BACKGROUND: The 24-hour (24-h) creatinine clearance (CrCl) is the most common method for measuring GFR in clinical laboratories.	Creatinine	31-41	CRCL	Homo sapiens	53-57
34248948-7	2021	In addition, the inhibitors against Syk and PAD4 attenuated lupus characteristics (serum creatinine, proteinuria, and anti-dsDNA) in Fcgr2b-/- mice at 120 h post-renal I/R injury.	Creatinine	89-99	MMTV LTR integration site 4	Mus musculus	44-48
35350849-4	2022	The median (interquartile range) of urinary Se was 49.0 (36.7, 67.4) microg/g creatinine.	Creatinine	78-88	squalene epoxidase	Homo sapiens	44-46
35350849-6	2022	In flexible dose-response models, increased risk for CVD incidence was only observed when urinary Se level exceeded 60 microg/g creatinine.	Creatinine	128-138	squalene epoxidase	Homo sapiens	98-100
35545234-3	2022	In addition, because TMP inhibits drug transporters, such as organic cation transporter 2 and multidrug and toxin extrusion protein 2-K in proximal tubules, reversible increases in the concentration of serum creatinine (SCr), the substrate of these transporters, may occur.	Creatinine	208-218	solute carrier family 22 member 2	Homo sapiens	61-89
35328045-5	2022	Regional plot association analysis of the GCKR gene region further revealed genome-wide significant associations between GCKR variants and serum total and low-density lipoprotein cholesterol; triglyceride, uric acid, creatinine, aspartate aminotransferase, gamma-Glutamyl transferase, albumin, and fasting plasma glucose levels; estimated glomerular filtration rate; leukocyte and platelet counts; microalbuminuria, and metabolic syndrome, with rs1260326 being the most common lead polymorphism.	Creatinine	217-227	glucokinase regulator	Homo sapiens	42-46
35328045-5	2022	Regional plot association analysis of the GCKR gene region further revealed genome-wide significant associations between GCKR variants and serum total and low-density lipoprotein cholesterol; triglyceride, uric acid, creatinine, aspartate aminotransferase, gamma-Glutamyl transferase, albumin, and fasting plasma glucose levels; estimated glomerular filtration rate; leukocyte and platelet counts; microalbuminuria, and metabolic syndrome, with rs1260326 being the most common lead polymorphism.	Creatinine	217-227	glucokinase regulator	Homo sapiens	121-125
35363362-11	2022	CONCLUSIONS: There is a direct relationship between circulating amounts of asprosin, visfatin, and subfatin hormones and age, weight, height, diastolic blood pressure, high-density lipoprotein-cholesterol, aspartate aminotransferase, alanine transaminase, and creatinine.	Creatinine	260-270	fibrillin 1	Homo sapiens	75-83
35071129-14	2021	The best performance to detect the increased tissue transit time and obstructive curve on RS was demonstrated by the beta2-M creatinine ratio.	Creatinine	125-135	alpha-2-macroglobulin	Homo sapiens	117-124
35465290-8	2022	In comparison with serum median OPN levels, serum OPN level was positively associated with KT duration (P = 0.048), serum blood urea nitrogen (BUN; P = 0.043), and serum creatinine levels (P = 0.045) but negatively associated with estimated glomerular filtration rate (eGFR; P = 0.049).	Creatinine	170-180	secreted phosphoprotein 1	Homo sapiens	50-53
2787201-7	1989	High-dose rIL-2 toxicity included fluid retention, increased creatinine, oliguria, elevated liver enzymes, and significant hypotension.	Creatinine	61-71	interleukin 2	Rattus norvegicus	10-15
2605793-3	1989	hEGF was measured by homologous radioimmunoassay and expressed in terms of urinary creatinine excretion.	Creatinine	83-93	epidermal growth factor	Homo sapiens	0-4
2605793-7	1989	There was an inverse correlation between albumin excretion rate and hEGF: creatinine ratio (r = -0.49; P = 0.02).	Creatinine	74-84	epidermal growth factor	Homo sapiens	68-72
2656332-7	1989	Serum creatinine showed a tendency (non-significant) to reflect the changes in beta 2-microglobulin concentration.	Creatinine	6-16	beta-2-microglobulin	Homo sapiens	79-99
3555125-2	1987	beta 2-microglobulin, but not creatinine, correlated significantly with creatinine clearance, indicating that beta 2-microglobulin is a more sensitive test than serum creatinine for monitoring glomerular filtration rate in chronic lithium therapy.	Creatinine	72-82	beta-2-microglobulin	Homo sapiens	0-20
3555125-2	1987	beta 2-microglobulin, but not creatinine, correlated significantly with creatinine clearance, indicating that beta 2-microglobulin is a more sensitive test than serum creatinine for monitoring glomerular filtration rate in chronic lithium therapy.	Creatinine	72-82	beta-2-microglobulin	Homo sapiens	110-130
3555125-2	1987	beta 2-microglobulin, but not creatinine, correlated significantly with creatinine clearance, indicating that beta 2-microglobulin is a more sensitive test than serum creatinine for monitoring glomerular filtration rate in chronic lithium therapy.	Creatinine	72-82	beta-2-microglobulin	Homo sapiens	0-20
3555125-2	1987	beta 2-microglobulin, but not creatinine, correlated significantly with creatinine clearance, indicating that beta 2-microglobulin is a more sensitive test than serum creatinine for monitoring glomerular filtration rate in chronic lithium therapy.	Creatinine	72-82	beta-2-microglobulin	Homo sapiens	110-130
3550218-3	1987	In five patients with serum creatinine levels above 3.0 mg/dl, FE beta 2m was elevated (range 3.5 to 196%) and serum levels were higher than normal (30,600 +/- 6,910 micrograms/liter vs. 1,268 +/- 111).	Creatinine	28-38	beta-2-microglobulin	Homo sapiens	66-73
3510938-8	1986	Finally, creatinine clearance corrected excretion of PGI-M, as an estimation of relative plasma levels correlates both with plasma renin activity and plasma aldosterone in the 31 subjects who presented with ascites.	Creatinine	9-19	pyroglutamyl-peptidase I	Homo sapiens	53-56
3884478-2	1985	Urine B2MG was significantly higher in these patients than in control patients with normal serum creatinine concentration.	Creatinine	97-107	beta-2-microglobulin	Homo sapiens	6-10
3911736-2	1985	In the total patient series, the reciprocals of S-creatinine and S-cystatin C were numerically and, in males, significantly more closely correlated to GFR than the reciprocals of S-factor D. The reciprocals of beta 2-microglobulin showed a weaker correlation to GFR than those of the other three substances.	Creatinine	48-60	beta-2-microglobulin	Homo sapiens	210-230
3868345-5	1985	AT III 25 U/kg and in combination with heparin showed marginal effects, 50 U/kg AT III resulted in increased survival rate and time, improvement of pathological changes of coagulation parameters and of blood urea nitrogen and serum creatinine levels.	Creatinine	232-242	serpin family C member 1	Homo sapiens	80-86
3888561-2	1985	beta 2-Microglobulin:creatinine ratio was significantly higher in preterm (4.43 +/- 0.88) than in full-term infants (0.89 +/- 0.42), but did not differ between infants exposed to betamethasone in utero and those who were not.	Creatinine	21-31	beta-2-microglobulin	Homo sapiens	0-20
3908127-4	1985	After the first DDP administration, there was a prompt, reversable and dose-dependent increase in the urinary excretion of beta 2 microglobulin with no difference between the two groups: Group A from 405 to 990 and Group B from 109 to 585 ng/mg creatinine.	Creatinine	245-255	beta-2-microglobulin	Homo sapiens	123-143
6518138-2	1984	Plasma creatinine concentrations ([Creat]p) were consistently elevated in partially nephrectomized (PNX) rats (P less than 0.001) and renal function ([Creat]p-1) was correlated with the amount of intact renal tissue (r = 0.624, P less than 0.001).	Creatinine	7-17	perforin 1	Rattus norvegicus	157-160
6525533-7	1984	In the antithrombin III group and the antithrombin III plus heparin group, however, creatinine clearance (Clcr) was moderately elevated while FENa and CH2O remained unchanged as compared with the values before the burn.	Creatinine	84-94	serpin family C member 1	Homo sapiens	38-54
6744593-1	1984	Interference by cefoxitin with determination of creatinine is less with the Technicon SMAC than with other commercial analytical systems.	Creatinine	48-58	diablo IAP-binding mitochondrial protein	Homo sapiens	86-90
6744593-3	1984	The apparent creatinine concentration measured for aqueous solutions of cefoxitin was 73 mmol of creatinine per mole of cefoxitin with the SMAC, 135 mmol/mol with a manual method.	Creatinine	13-23	diablo IAP-binding mitochondrial protein	Homo sapiens	139-143
6744593-4	1984	Furthermore, we determined for the SMAC that the average fraction of creatinine dialyzed was 0.128 and for cefoxitin, 0.064.	Creatinine	69-79	diablo IAP-binding mitochondrial protein	Homo sapiens	35-39
6744593-5	1984	Thus, the concentration of and interference by cefoxitin in the reaction mixture for SMAC are reduced by half (i.e., the apparent creatinine concentration for cefoxitin with the manual system multiplied by 0.5 is essentially that noted with the SMAC: 68 vs 73).	Creatinine	130-140	diablo IAP-binding mitochondrial protein	Homo sapiens	85-89
6744593-5	1984	Thus, the concentration of and interference by cefoxitin in the reaction mixture for SMAC are reduced by half (i.e., the apparent creatinine concentration for cefoxitin with the manual system multiplied by 0.5 is essentially that noted with the SMAC: 68 vs 73).	Creatinine	130-140	diablo IAP-binding mitochondrial protein	Homo sapiens	245-249
6744593-6	1984	Thus we conclude that the diminished interference be cefoxitin with determination of creatinine by SMAC is primarily ascribable to the dialysis step.	Creatinine	85-95	diablo IAP-binding mitochondrial protein	Homo sapiens	99-103
6382139-7	1984	The lipoprotein lipase activities were low in patients with endogenous creatinine clearance less than 20 ml/min/m2.	Creatinine	71-81	lipoprotein lipase	Homo sapiens	4-22
6428899-4	1984	beta 2 microglobulin clearance X 10(3) creatinine clearance rose from a mean of 0.4 (SD 0.1) to a mean of 74.5 (SD 32.3) and N-acetyl-beta-D-glucosaminidase from 54.2 units/mmol creatinine (SD 18.0) to 1525 units/mmol creatinine (SD 2318).	Creatinine	39-49	beta-2-microglobulin	Homo sapiens	0-20
6372730-4	1984	In the 29 children with glomerular filtration rate (GFR) ranging from 20 to 100 ml/min/1.73 m2, there was a significant correlation between B2M and the inulin clearance, plasma creatinine level and creatinine clearance (p less than 0.001).	Creatinine	198-208	beta-2-microglobulin	Homo sapiens	140-143
6361371-5	1983	A close correlation was found between beta 2-MG levels and endogeneous creatinine clearance.	Creatinine	71-81	beta-2-microglobulin	Homo sapiens	38-47
6607183-9	1983	Urinary levels of EGF per mg creatinine in normal children were significantly higher than those in normal males or females.	Creatinine	29-39	epidermal growth factor	Homo sapiens	18-21
6607183-10	1983	There was a reverse correlation between serum creatinine levels and urinary EGF levels per creatinine.	Creatinine	46-56	epidermal growth factor	Homo sapiens	76-79
6607183-10	1983	There was a reverse correlation between serum creatinine levels and urinary EGF levels per creatinine.	Creatinine	91-101	epidermal growth factor	Homo sapiens	76-79
6874317-1	1983	Renal clearance of lipase, expressed as a proportion of simultaneous creatinine clearances was evaluated in an experimental model of acute pancreatitis in the rat.	Creatinine	69-79	lipase G, endothelial type	Rattus norvegicus	19-25
6874317-2	1983	The lipase creatinine clearance ratio resulted very low in normal and control animals, while in rats with acute pancreatitis it increased regularly, significantly and proportionally to the degree of pancreatic damage.	Creatinine	11-21	lipase G, endothelial type	Rattus norvegicus	4-10
6874317-3	1983	These observations indicated that, in this experimental model, the increased lipase creatinine clearance ratio is a sensitive index of acute pancreatitis, providing a basis for using the test in clinical practice.	Creatinine	84-94	lipase G, endothelial type	Rattus norvegicus	77-83
6182073-6	1982	In rats given gentamicin (20 or 80 mg/kg/day, s.c.) for 10 days, serum beta 2-M was increased simultaneously with changes in common renal function parameters such as serum urea nitrogen, creatinine, and urinary protein.	Creatinine	187-197	beta-2 microglobulin	Rattus norvegicus	71-79
6159827-3	1980	Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels.	Creatinine	145-155	beta-2-microglobulin	Homo sapiens	71-80
6157048-7	1980	The increased beta 2M excretion greater than 50 mg/day preceded the serum creatinine rise by 2 to 7 days.	Creatinine	74-84	beta-2-microglobulin	Homo sapiens	14-21
6767572-0	1980	Drift in SMAC-determined serum creatinine can be reduced by adding EDTA to the creatinine recipient solution.	Creatinine	31-41	diablo IAP-binding mitochondrial protein	Homo sapiens	9-13
6767572-0	1980	Drift in SMAC-determined serum creatinine can be reduced by adding EDTA to the creatinine recipient solution.	Creatinine	79-89	diablo IAP-binding mitochondrial protein	Homo sapiens	9-13
6159767-4	1980	Serum creatinine levels were significantly correlated to beta 2-microglobulin levels.	Creatinine	6-16	beta-2-microglobulin	Homo sapiens	57-77
86616-6	1979	In bladder cancer patients with normal serum creatinine the frequency of an elevated serum beta-2-microglobulin increased with the increase in tumor stage.	Creatinine	45-55	beta-2-microglobulin	Homo sapiens	91-111
92308-0	1979	Amniotic fluid beta 2 microglobulin: correlation with L/S ratios and creatinine levels.	Creatinine	69-79	beta-2-microglobulin	Homo sapiens	15-35
392694-4	1979	Serum myoglobin was positively correlated to age (P less than 0.05), body weight (P less than 0.02), serum creatine kinase (P less than 0.001), and serum creatinine (P less than 0.001) to galactose elimination rate.	Creatinine	154-164	myoglobin	Homo sapiens	6-15
86264-3	1979	Initially during acute pancreatitis, the clearance ratio (clearance protein/clearance creatinine) for beta-2-microglobulin was increased dramatically (77-fold) compared to normals.	Creatinine	86-96	beta-2-microglobulin	Homo sapiens	102-122
531528-4	1979	A negative correlation was found between AT-III and serum creatinine and between AT-III and serum albumin.	Creatinine	58-68	serpin family C member 1	Homo sapiens	41-47
253374-5	1978	Higher doses (140 pmol.h-1) were significantly pressor and caused increased excretion of sodium, chloride, urea and creatinine.	Creatinine	116-126	H1.5 linker histone, cluster member	Homo sapiens	23-26
340602-2	1978	The myoglobin level was significantly correlated to different variables of GFR such as serum beta2-microglobulin, serum creatinine, and 51Cr-EDTA clearance.	Creatinine	120-130	myoglobin	Homo sapiens	4-13
84347-3	1978	In relation to endogenous clearance of creatinine the clearance of transferrin, IgG and alpha2-macroglobulin increased significantly.	Creatinine	39-49	alpha-2-macroglobulin	Homo sapiens	88-108
4550871-2	1972	When the serum creatinine level was used as an index of the degree of renal impairment serum gastrin rose proportionately with the degree of renal failure.	Creatinine	15-25	gastrin	Homo sapiens	93-100
4978446-11	1969	Estimates on sera revealed a close correlation between serum levels of beta(2)-microglobulin and creatinine and also a greatly raised serum concentration of beta(2)-microglobulin after bilateral nephrectomy.	Creatinine	97-107	beta-2-microglobulin	Homo sapiens	71-92
34016718-8	2021	SOCS3-cKO mice exhibited severe glomerulonephritis, high levels of serum creatinine and urine albumin and decreased survival rate compared with control SOCS3-WT mice.	Creatinine	73-83	suppressor of cytokine signaling 3	Mus musculus	0-5
33970086-10	2021	SGLT2 inhibitors were discontinued in 47.4% of patients, with the top reasons including increase in serum creatinine (8%) and urinary or genital side effects (5.6%).	Creatinine	106-116	solute carrier family 5 member 2	Homo sapiens	0-5
33906273-0	2021	[Urinary retinol binding protein and beta2-microglobulin were associated with urinary albumin to creatinine ratio and renal function in hospitalized diabetic patients].	Creatinine	97-107	beta-2-microglobulin	Homo sapiens	37-56
33906273-1	2021	Objective: To explore the associations of urinary retinol binding protein (RBP) and beta2-microglobulin (beta2-MG) with urinary albumin to creatinine ratio (UACR) and renal function in hospitalized patients with type 2 diabetes mellitus (T2DM).	Creatinine	139-149	beta-2-microglobulin	Homo sapiens	84-103
33995039-11	2021	Both the free and total MTX concentrations at 42 h were negatively correlated with the creatinine clearance (CCr) level (P = 0.023, r = -0.236 for total MTX and P = 0.020, r = -0.241for free MTX, respectively).	Creatinine	87-97	metaxin 1	Homo sapiens	24-27
33907298-7	2021	Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning.	Creatinine	127-137	microRNA 21	Homo sapiens	168-174
33881796-0	2021	Urinary dipeptidyl peptidase-4 protein is increased by linagliptin and is a potential predictive marker of urine albumin-to-creatinine ratio reduction in patients with type 2 diabetes.	Creatinine	124-134	dipeptidyl peptidase 4	Homo sapiens	8-30
33881796-1	2021	Results of a post-hoc analysis of urinary dipeptidyl peptidase-4 (DPP-4) protein as a predictor of urinary albumin-to-creatinine ratio (UACR) response to linagliptin treatment based on MARLINA-T2D trial data are described.	Creatinine	118-128	dipeptidyl peptidase 4	Homo sapiens	42-64
33881796-1	2021	Results of a post-hoc analysis of urinary dipeptidyl peptidase-4 (DPP-4) protein as a predictor of urinary albumin-to-creatinine ratio (UACR) response to linagliptin treatment based on MARLINA-T2D trial data are described.	Creatinine	118-128	dipeptidyl peptidase 4	Homo sapiens	66-71
33881796-4	2021	Furthermore, medium urinary DPP-4 protein levels (between 5.5 and 7.5 natural logarithmic (ln) mug/g creatinine) at baseline allowed for prediction of improved UACR in linagliptin-treated individuals.	Creatinine	101-111	dipeptidyl peptidase 4	Homo sapiens	28-33
33928100-7	2021	The results showed that EPO significantly decreased serum creatinine, blood urea nitrogen, and cystatin C levels and alleviated renal histological changes in vivo.	Creatinine	58-68	erythropoietin	Mus musculus	24-27
33759548-8	2021	Reduction of protein/creatinine (AUC) was observed in p53sh-EPC-transplanted mice more than null-EPC (1.8-fold, P=0.03) or null-mMSC (1.6-fold, P=0.04, n=4) transplanted mice.	Creatinine	21-31	transformation related protein 53, pseudogene	Mus musculus	54-57
33870013-8	2021	Each interquartile range (0.53 mug/g creatinine) increment in urine ln-Se concentration during the first trimester was associated with a mean 21.7 g (95% CI = -41.3g to -2.1g) decrease in birth weight and 3.6g (95% CI = -6.3g to -0.9g) decrease in placental weight.	Creatinine	37-47	squalene epoxidase	Homo sapiens	71-73
32892508-10	2021	Multivariate survival analysis showed that the urinary EGF level was associated with time to doubling of the serum creatinine level (DSCr), a marker of future end-stage kidney disease (ESKD) (hazard ratio 0.88, 95% confidence interval 0.77-0.99, P = 0.045).	Creatinine	115-125	epidermal growth factor	Homo sapiens	55-58
33079290-9	2021	Levels of serum Slit2 in patients with CKD were positively correlated with serum creatinine, urine protein, and glomerular filtration rate.	Creatinine	81-91	slit guidance ligand 2	Homo sapiens	16-21
32321335-9	2021	Soluble TREM-1 levels were found in correlation with creatinine and CRP in the FMF patient group regardless of their amyloidosis diagnosis (r = 0.314, p = .013; r = 0.846, p < .001).Conclusion: TREM-1 seems to be related to renal function rather than disease activity in FMF.	Creatinine	53-63	triggering receptor expressed on myeloid cells 1	Homo sapiens	8-14
32083963-8	2021	Results: In NAC nomogram, NIHSS (National Institutes of Health Stroke Scale) score on admission (OR: 1.193, p &lt; 0.0001), Age (OR: 1.025, p = 0.037) and Creatinine (OR: 1.028, p &lt; 0.0001) remained independent predictors of 3-month unfavorable outcome in Chinese AIS patients treated with MT.	Creatinine	155-165	synuclein alpha	Homo sapiens	12-15
32856274-2	2021	Increase in serum creatinine levels is considered a result of competition with abemaciclib via organic cation transporter 2 and multidrug and toxic compound extrusion.	Creatinine	18-28	solute carrier family 22 member 2	Homo sapiens	95-123
33953855-7	2021	Combination therapy with VD3 and EPO markedly improved Creatinine clearance rate (CCr).	Creatinine	55-65	erythropoietin	Rattus norvegicus	33-36
33303872-5	2020	In T2D, FKBPL was negatively correlated with fasting blood glucose, HbA1c and diastolic blood pressure (DBP), and positively correlated with age, known diabetes duration, waist/hip ratio, urinary albumin/creatinine ratio (ACR) and fasting C-peptide.	Creatinine	204-214	FKBP prolyl isomerase like	Homo sapiens	8-13
33287461-6	2020	FABP4 concentrations were up-regulated in culture supernatants of MNCs from CAD patients, which were positively correlated with the patients" age, waist-hip ratio, body mass index, serum creatinine, type 2 diabetes, and the presence of hypertension.	Creatinine	187-197	fatty acid binding protein 4	Homo sapiens	0-5
33401355-4	2020	RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001).	Creatinine	75-85	C-C motif chemokine ligand 2	Homo sapiens	39-44
33401355-4	2020	RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001).	Creatinine	181-191	C-C motif chemokine ligand 2	Homo sapiens	39-44
33401355-4	2020	RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001).	Creatinine	181-191	C-C motif chemokine ligand 2	Homo sapiens	39-44
33105946-16	2020	The creatinine levels of patients between the two groups on PID 1, 2, and 3 were similar.	Creatinine	4-14	phosphotyrosine interaction domain containing 1	Homo sapiens	60-75
32533906-2	2020	AIMS: We aimed to determine the efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1ra) to prevent worsening urinary albumin-to-creatinine ratio as an early biomarker of diabetes kidney disease.	Creatinine	202-212	solute carrier family 5 member 2	Homo sapiens	55-85
32666494-5	2020	DLX6-AS1 expression were positively associated with the creatinine levels in the serum from the septic AKI patients.	Creatinine	56-66	distal-less homeobox 6	Homo sapiens	0-4
33101034-9	2020	Results: Plasma H19 was significantly up-regulated in patients with aspirin resistance (p=0.0203), and the H19 levels were positively associated with urine 11dhTXB2/creatinine (R=0.04364, p=0.0106) and positively associated with the level of 8-iso-PGF2alpha (R=0.04561, p=0.0089).	Creatinine	165-175	H19 imprinted maternally expressed transcript	Homo sapiens	107-110
32961912-8	2020	Blood biochemical parameters showed that Broiler chickens fed on the SP2 diet had higher levels of total protein (TP) (p <= 0.05), albumin (ALB) (p <= 0.05), creatinine (CRE) (p <= 0.05), and aspartate aminotransferase (AST) (p <= 0.05) and, lower level of uric acid (UA) (p <= 0.05), blood urea nitrogen (BUN) (p <= 0.05), glucose (GLU) (p <= 0.05), and alanine aminotransferase (ALT) (p <= 0.05) in the starter phase; however, higher level of TP (p <= 0.05), GLU (p <= 0.05), CRE (p <= 0.05), and AST (p <= 0.05), and lower level of ALB (p <= 0.05), UA (p <= 0.05), and ALT (p <= 0.05) in the grower phase; RPGC had higher level of TP (p <= 0.05), UA (p <= 0.05), GLU (p <= 0.05), ALT (p <= 0.05) and AST (p <= 0.05), and lower level of ALB (p <= 0.05), BUN (p <= 0.05), and CRE (p <= 0.05) in the starter phase; however, in grower phase, RPGC had higher level of TP (p <= 0.05), and ALB (p <= 0.05), and lower level of UA (p <= 0.05), CRE (p <= 0.05), ALT (p <= 0.05), and AST (p <= 0.05).	Creatinine	158-168	Sp2 transcription factor	Gallus gallus	69-72
32961912-8	2020	Blood biochemical parameters showed that Broiler chickens fed on the SP2 diet had higher levels of total protein (TP) (p <= 0.05), albumin (ALB) (p <= 0.05), creatinine (CRE) (p <= 0.05), and aspartate aminotransferase (AST) (p <= 0.05) and, lower level of uric acid (UA) (p <= 0.05), blood urea nitrogen (BUN) (p <= 0.05), glucose (GLU) (p <= 0.05), and alanine aminotransferase (ALT) (p <= 0.05) in the starter phase; however, higher level of TP (p <= 0.05), GLU (p <= 0.05), CRE (p <= 0.05), and AST (p <= 0.05), and lower level of ALB (p <= 0.05), UA (p <= 0.05), and ALT (p <= 0.05) in the grower phase; RPGC had higher level of TP (p <= 0.05), UA (p <= 0.05), GLU (p <= 0.05), ALT (p <= 0.05) and AST (p <= 0.05), and lower level of ALB (p <= 0.05), BUN (p <= 0.05), and CRE (p <= 0.05) in the starter phase; however, in grower phase, RPGC had higher level of TP (p <= 0.05), and ALB (p <= 0.05), and lower level of UA (p <= 0.05), CRE (p <= 0.05), ALT (p <= 0.05), and AST (p <= 0.05).	Creatinine	478-481	Sp2 transcription factor	Gallus gallus	69-72
32961912-8	2020	Blood biochemical parameters showed that Broiler chickens fed on the SP2 diet had higher levels of total protein (TP) (p <= 0.05), albumin (ALB) (p <= 0.05), creatinine (CRE) (p <= 0.05), and aspartate aminotransferase (AST) (p <= 0.05) and, lower level of uric acid (UA) (p <= 0.05), blood urea nitrogen (BUN) (p <= 0.05), glucose (GLU) (p <= 0.05), and alanine aminotransferase (ALT) (p <= 0.05) in the starter phase; however, higher level of TP (p <= 0.05), GLU (p <= 0.05), CRE (p <= 0.05), and AST (p <= 0.05), and lower level of ALB (p <= 0.05), UA (p <= 0.05), and ALT (p <= 0.05) in the grower phase; RPGC had higher level of TP (p <= 0.05), UA (p <= 0.05), GLU (p <= 0.05), ALT (p <= 0.05) and AST (p <= 0.05), and lower level of ALB (p <= 0.05), BUN (p <= 0.05), and CRE (p <= 0.05) in the starter phase; however, in grower phase, RPGC had higher level of TP (p <= 0.05), and ALB (p <= 0.05), and lower level of UA (p <= 0.05), CRE (p <= 0.05), ALT (p <= 0.05), and AST (p <= 0.05).	Creatinine	478-481	Sp2 transcription factor	Gallus gallus	69-72
32961912-8	2020	Blood biochemical parameters showed that Broiler chickens fed on the SP2 diet had higher levels of total protein (TP) (p <= 0.05), albumin (ALB) (p <= 0.05), creatinine (CRE) (p <= 0.05), and aspartate aminotransferase (AST) (p <= 0.05) and, lower level of uric acid (UA) (p <= 0.05), blood urea nitrogen (BUN) (p <= 0.05), glucose (GLU) (p <= 0.05), and alanine aminotransferase (ALT) (p <= 0.05) in the starter phase; however, higher level of TP (p <= 0.05), GLU (p <= 0.05), CRE (p <= 0.05), and AST (p <= 0.05), and lower level of ALB (p <= 0.05), UA (p <= 0.05), and ALT (p <= 0.05) in the grower phase; RPGC had higher level of TP (p <= 0.05), UA (p <= 0.05), GLU (p <= 0.05), ALT (p <= 0.05) and AST (p <= 0.05), and lower level of ALB (p <= 0.05), BUN (p <= 0.05), and CRE (p <= 0.05) in the starter phase; however, in grower phase, RPGC had higher level of TP (p <= 0.05), and ALB (p <= 0.05), and lower level of UA (p <= 0.05), CRE (p <= 0.05), ALT (p <= 0.05), and AST (p <= 0.05).	Creatinine	478-481	Sp2 transcription factor	Gallus gallus	69-72
32952008-3	2021	We investigated whether the modified creatinine index (mCI), which is a surrogate marker of muscle mass, could predict mortality and cardiovascular (CV) hospitalizations independent of muscle function and other confounders in patients on hemodialysis.	Creatinine	37-47	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	55-58
33082773-8	2020	Combined analysis of all samples revealed creatinine-adjusted ApoC3 levels to be significantly higher in the AD+MCI group (p = 0.015) and the AD-only group (p = 0.011) relative to the control group.	Creatinine	42-52	apolipoprotein C3	Homo sapiens	62-67
33376682-2	2020	The Cockcroft-Gault (CG) equation is widely used but has questionable validity for females, changing renal function, and the critical ill. Eight-hour urine collections (U8h) offer direct measurement of creatinine clearance (CrCl) but lack the data for drug dosing.	Creatinine	202-212	CRCL	Homo sapiens	224-228
32524495-7	2020	Only SGLT-2 inhibitors illustrated significantly lower hazard ratios of doubling of serum creatinine and incidence of renal replacement therapy (RRT).	Creatinine	90-100	solute carrier family 5 member 2	Homo sapiens	5-11
32989074-11	2020	This case highlights the need for clinicians to be aware of anti-HMGCR myopathy and to consider it as a potential cause of proximal muscle weakness and persistent serum creatinine kinase elevations in patients exposed to statins even if they were previously well tolerated by the patient.	Creatinine	169-179	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	65-70
32484987-6	2020	miR-126 expression was positively correlated with acute physiology and chronic health evaluation II score, serum creatinine, and C-reactive protein but not albumin or white blood cell count in sepsis patients.	Creatinine	113-123	microRNA 126	Homo sapiens	0-7
32578294-8	2020	Furthermore, lnc-TCF7 expression positively correlated with serum creatinine, beta-2-microglobulin, and lactate dehydrogenase in patients.	Creatinine	66-76	transcription factor 7	Homo sapiens	17-21
32839213-7	2020	Treatment with anti-G-CSFR protected against renal IRI in a dose-dependent manner, significantly reducing serum creatinine and urea, tubular injury, neutrophil and macrophage infiltration, and complement activation (plasma C5a) and deposition (tissue C9).	Creatinine	112-122	colony stimulating factor 3 receptor (granulocyte)	Mus musculus	20-26
32803273-8	2020	Obese hCN1 transgenic BTBROb/Ob mice displayed significantly higher levels of glycated hemoglobin, glycosuria, proteinuria, and increased albumin-creatinine ratios (1104 +- 696 vs 492.1 +- 282.2 mug/mg) accompanied by an increased glomerular tuft area and renal corpuscle size.	Creatinine	146-156	carnosine dipeptidase 1	Homo sapiens	6-10
30580611-3	2020	Blood urea and creatinine (AKI biomarkers, in g dL-1) were elevated after 2 h in venom-treated rats (urea: from 0.41 +- 0.1 to 0.7 +- 0.03; creatinine from 46.7 +- 3.1 to 85 +- 6.7; p < 0.05; n = 3 each), with no change in circulating reduced glutathione.	Creatinine	15-25	l(1)L1	Drosophila melanogaster	48-52
32552645-12	2021	MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients.	Creatinine	102-112	mannose binding lectin 2	Homo sapiens	0-3
32626757-10	2020	Decreased hsa-let-7c-5p levels in CKD patients was found to be associated with disease severity, which shows a negative correlation with proteinuria and creatinine levels, and a positive correlation with estimated glomerular filtration rate (eGFR), while relative TGF-beta1 expression had a positive correlation with creatinine level.	Creatinine	153-163	microRNA let-7c	Homo sapiens	10-20
32626757-10	2020	Decreased hsa-let-7c-5p levels in CKD patients was found to be associated with disease severity, which shows a negative correlation with proteinuria and creatinine levels, and a positive correlation with estimated glomerular filtration rate (eGFR), while relative TGF-beta1 expression had a positive correlation with creatinine level.	Creatinine	317-327	microRNA let-7c	Homo sapiens	10-20
32027040-5	2020	Recombinant CTRP6 protein protected against renal I/R injury by the reduction of blood urea nitrogen (BUN) and creatinine levels.	Creatinine	111-121	C1q and tumor necrosis factor related protein 6	Mus musculus	12-17
32481361-8	2020	Besides, MiR-146a and miR-146b expressions were positively correlated with acute pathologic and chronic health evaluation II score, sequential organ failure assessment score, serum creatinine, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-17, while negatively correlated with albumin.	Creatinine	181-191	microRNA 146a	Homo sapiens	9-17
32466262-4	2020	Yet, circumstantial evidence suggests that treatment with SGLT2 inhibitors does result in a loss of muscle mass, rendering serum creatinine-based kidney endpoints invalid.	Creatinine	129-139	solute carrier family 5 member 2	Homo sapiens	58-63
32404057-1	2020	BACKGROUND: The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring.	Creatinine	111-121	CRCL	Homo sapiens	133-137
32523820-3	2020	We describe a case of anti-HMGCR myopathy in a 59-year-old male with a prior history of statin intolerance presenting with markedly elevated creatinine kinase, myoglobinuria, and one month of progressive proximal muscle weakness after restarting atorvastatin 10 months prior to admission.	Creatinine	141-151	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	27-32
32200667-6	2020	The results showed that the urinary albumin creatinine ratio was significantly reduced when both PAR1 and PAR2 were blocked with E5555 + FSLLRY compared with the vehicle-treated group.	Creatinine	44-54	coagulation factor II (thrombin) receptor	Mus musculus	97-101
32200667-6	2020	The results showed that the urinary albumin creatinine ratio was significantly reduced when both PAR1 and PAR2 were blocked with E5555 + FSLLRY compared with the vehicle-treated group.	Creatinine	44-54	pulmonary adenoma resistance 2	Mus musculus	106-110
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	136-146	microRNA 9-3	Homo sapiens	34-40
32086547-8	2020	Five microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) had a highly significant correlation with normalized urinary albumin, serum creatinine at 24 h and creatinine clearance.	Creatinine	159-169	microRNA 9-3	Homo sapiens	34-40
32441176-8	2020	Compared with the control group, the beta-TM group had significantly higher levels of urine protein/creatinine, urine beta2-MG, urine beta2-MG/creatinine, urine NGAL, urine NGAL/creatinine, and serum endocan.	Creatinine	100-110	ATM serine/threonine kinase	Homo sapiens	37-44
32441176-8	2020	Compared with the control group, the beta-TM group had significantly higher levels of urine protein/creatinine, urine beta2-MG, urine beta2-MG/creatinine, urine NGAL, urine NGAL/creatinine, and serum endocan.	Creatinine	143-153	ATM serine/threonine kinase	Homo sapiens	37-44
32441176-8	2020	Compared with the control group, the beta-TM group had significantly higher levels of urine protein/creatinine, urine beta2-MG, urine beta2-MG/creatinine, urine NGAL, urine NGAL/creatinine, and serum endocan.	Creatinine	143-153	ATM serine/threonine kinase	Homo sapiens	37-44
32060504-10	2020	ABCC10 2843T>C (rs2125739) was significantly associated with lower log10 baseline creatinine (P = 0.001, beta= -0.4), higher baseline CLCR (P = 0.008, beta = 65.2) and lower CLCR after 1 year (P = 0.024, beta= -26.6).	Creatinine	82-92	ATP binding cassette subfamily C member 10	Homo sapiens	0-6
32324955-10	2020	Both u-hemojuvelin and UHCR were significantly correlated with high blood urea nitrogen, plasma creatinine, and plasma phosphate concentrations and with low hematocrit (Hct), red blood cell (RBC) count, and plasma albumin concentration.	Creatinine	96-106	hemojuvelin BMP co-receptor	Homo sapiens	7-18
32107537-12	2020	Additionally, nephrotic-range albuminuria with an albumin-to-creatinine-ratio (ACR) >220 mg/mmol was a significantly adverse factor for hemEFS (hazard ratio, 2.1 and 3.1) with DD and DVD.	Creatinine	61-71	acrosin	Homo sapiens	79-82
31392659-7	2020	Notably, central blockade of the wnt signaling improved renal function as indicated by decreased serum creatinine and 24 h urinary protein, and attenuated interstitial fibrosis as indicated by reduced Sirius red staining and expression of Fibronectin, Collagen-I and alpha-SMA.	Creatinine	103-113	Wnt family member 2	Rattus norvegicus	33-36
32317861-6	2020	Correlation analysis demonstrated a negative association between renal CXCL14 expression and AKI markers including serum creatinine and renal NGAL.	Creatinine	121-131	chemokine (C-X-C motif) ligand 14	Mus musculus	71-77
32317861-7	2020	Moreover, CXCL14 overexpression reduced cytokine (TNF-alpha, IL-6, and IL-1beta) production and NGAL expression in the kidney and decreased serum creatinine levels.	Creatinine	146-156	chemokine (C-X-C motif) ligand 14	Mus musculus	10-16
32102616-9	2020	Kidney inflammation and oxidative stress, as well as blood urea and creatinine levels, were also more pronounced in old hypertensive ERalpha-/- and AF2  than in old hypertensive wild-type and C451A mice.	Creatinine	68-78	estrogen receptor 1 (alpha)	Mus musculus	133-140
32068457-10	2020	Renal cell apoptosis and plasma creatinine were significantly increased in wild-type versus OLFM4-null pups.	Creatinine	32-42	olfactomedin 4	Mus musculus	92-97
32165595-8	2020	Plasma miR-29a was positively correlated with eGFR and negatively correlated with proteinuria and serum creatinine, irrespective of whether or not the patients with IgAN accepted treatment (P < .05).	Creatinine	104-114	microRNA 29a	Homo sapiens	7-14
31722957-3	2020	Albuminuria is the currently accepted marker for detection of DN.This study aims to evaluate the urinary level of two novel renal tubular proteins (cyclophilin A and periostin) in patients with T2DM and among different nephropathy stages and also to validate the diagnostic accuracy of both cyclophilin A and periostin as potential markers for early prediction of DN relative to albuminuria.This cross-sectional study recruited 137 patients with T2DM, and they were divided based on their urinary albumin:creatinine ratio into T2DM with normoalbuminuria (group II), incipient T2DN with microalbuminuria (group III) and overt T2DN with macroalbuminuria (group IV) beside 41 healthy subjects as group I Cyclophilin A and periostin were measured in the urine using ELISA.	Creatinine	505-515	periostin	Homo sapiens	148-175
31867735-6	2020	A significant association was found between cardiac troponin I and creatinine concentrations.	Creatinine	67-77	troponin I3, cardiac type	Canis lupus familiaris	44-62
31940606-7	2020	As such, clinicians who encounter rises in serum creatinine during intensification of hypertension therapy should "stay calm and carry on."	Creatinine	49-59	synaptosome associated protein 91	Homo sapiens	120-124
31655022-4	2020	Key Results I/R injury up-regulated renal expression of FOXO1, and treatment with FOXO1-selective inhibitor AS1842856 prior to I/R injury decreased serum urea nitrogen, serum creatinine and the tubular damage score after injury.	Creatinine	175-185	forkhead box O1	Mus musculus	82-87
31746731-8	2020	In the correlation analysis, the serum E-selectin level was significantly correlated to glucose, alanine transaminase, creatinine, calcium, phosphorus, total protein, albumin, and end diastolic volume (p = 0.0001, p = 0.001, p = 0.03, p = 0.021, p = 0.023, p = 0.002, p = 0.003, and p = 0.047, respectively).	Creatinine	119-129	selectin E	Homo sapiens	39-49
32818935-9	2020	The median urinary hepcidin level in the group fed breast milk was lower than in formula (130 vs. 359 ng hepcidin/mg creatinine, p < 0.05).	Creatinine	117-127	hepcidin antimicrobial peptide	Homo sapiens	19-27
33221810-8	2020	In 16 index biopsies, serum creatinine increases significantly correlated with the percentage of VP1-positive tubules (r = 0.49, p = 0.02), while this correlation revealed borderline significance with TAg-positive tubules.	Creatinine	28-38	VP1	Human polyomavirus 1	97-100
31857626-4	2019	In an angiotensin II (Ang II)-induced renal injury mouse model, we found that blocking AT1R and AT2R effectively mitigates Ang II-induced increases in necroptotic tubular epithelial cell percentages, necroptosis-related RIP3 and MLKL protein expression, serum creatinine and blood urea nitrogen levels, and tubular damage scores.	Creatinine	260-270	angiotensin II, type I receptor-associated protein	Mus musculus	87-91
31317556-7	2019	We simulated concentrations over 48 hours in typical subjects with decreasing creatinine clearance (CrCl), estimated using the updated bedside Schwartz equation.	Creatinine	78-88	CRCL	Homo sapiens	100-104
31781668-8	2019	Conclusion: Our results confirmed that blood pressure management status after treatment with SGLT2 inhibitors influences the extent of change in urinary albumin-creatinine ratio.	Creatinine	161-171	solute carrier family 5 member 2	Homo sapiens	93-98
31710440-0	2019	Analytical and Biological Variability of Urinary Epidermal Growth Factor-to-Creatinine Ratio in Patients with Chronic Kidney Disease and in Healthy Volunteers.	Creatinine	76-86	epidermal growth factor	Homo sapiens	49-72
31710440-1	2019	BACKGROUND: Urinary levels of epidermal growth factor to creatinine ratio are considered as an early predictor of interstitial kidney fibrosis but so far no data are available on their biological variation (BV) and derived parameters.	Creatinine	57-67	epidermal growth factor	Homo sapiens	30-53
31710440-2	2019	The aim of this study is to determine the BV of epidermal growth factor to creatinine ratio in patients with chronic kidney disease and in healthy volunteers.	Creatinine	75-85	epidermal growth factor	Homo sapiens	48-71
31710440-5	2019	Measurements of EGF were done by ELISA and expressed as EGF/creatinine ratio.	Creatinine	60-70	epidermal growth factor	Homo sapiens	16-19
31511257-12	2019	N1-methyladenosine (m1A) was found as the novel substrate of renal cationic drug transporters, OCT2 and MATE2-K. m1A was revealed to have some advantages compared to other OCT2/MATEs substrate, creatinine and N1-methylnicotinamide.	Creatinine	194-204	solute carrier family 47, member 2	Mus musculus	104-109
31568615-9	2019	A weak positive relationship was demonstrated between plasma FGF23 and SDMA concentrations (r = .35, P < .001) and between plasma FGF23 and creatinine (r = .23, P = .005) concentrations.	Creatinine	140-150	fibroblast growth factor 23	Felis catus	130-135
31594992-7	2019	Greater renal blood flow and lower serum creatinine were observed after reperfusion in VWF-KO mice compared with wild-type (WT) mice.	Creatinine	41-51	Von Willebrand factor	Mus musculus	87-90
31286669-5	2019	Selective inhibition of FABP4 by BMS309403 at 40 mg/kg/d for 3 days and genetic knockout of FABP4 significantly attenuated the serum creatinine, blood urea nitrogen level and renal tubular damage.	Creatinine	133-143	fatty acid binding protein 4, adipocyte	Mus musculus	24-29
31286669-5	2019	Selective inhibition of FABP4 by BMS309403 at 40 mg/kg/d for 3 days and genetic knockout of FABP4 significantly attenuated the serum creatinine, blood urea nitrogen level and renal tubular damage.	Creatinine	133-143	fatty acid binding protein 4, adipocyte	Mus musculus	92-97
31517819-8	2019	Both the frequency of AR and levels of creatinine (3 and 6 months after KTx) were significantly higher in patients with an increased CD200R1/CD200 ratio (median: 126 vs 78, P = .008).	Creatinine	39-49	CD200 molecule	Homo sapiens	133-138
30601337-8	2019	Age and sex adjusted fetuin-B demonstrated positive correlations with triglycerides, gamma-glutamyl transferase, fasting plasma glucose, 2-h postprandial plasma glucose, homeostasis model assessment of IR, fasting insulin, glycated hemoglobin, high-sensitivity C-reactive protein, and estimated glomerular filtration rate, but it had a negative correlation with serum creatinine.	Creatinine	368-378	fetuin B	Homo sapiens	21-29
30808234-10	2019	Elevated renal miR-21 expression positively correlated with 24 h urine protein, serum blood urea nitrogen, serum creatinine, and severity of kidney pathology.	Creatinine	113-123	microRNA 21	Homo sapiens	15-21
30656565-7	2019	A 35-year-old, 70-kg patient with a serum creatinine level of 0.83 mg dL-1 (73.4 micromol L-1) has a V1, V2, CL and Q2 of 42.9 L, 41.7 L, 4.10 L h-1 and 3.22 L h-1.	Creatinine	42-52	l(1)L1	Drosophila melanogaster	70-74
30656565-7	2019	A 35-year-old, 70-kg patient with a serum creatinine level of 0.83 mg dL-1 (73.4 micromol L-1) has a V1, V2, CL and Q2 of 42.9 L, 41.7 L, 4.10 L h-1 and 3.22 L h-1.	Creatinine	42-52	l(1)L1	Drosophila melanogaster	71-74
30880174-3	2019	When a gender-stratified analysis was ran, the miR-146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed.	Creatinine	159-169	microRNA 146a	Homo sapiens	47-55
31076148-7	2019	RESULTS: With multivariate linear regression, the latest estimated glomerular filtration rate has a strong linear relationship with initial ACR (B = -0.032; P = .02), suggesting each unit rise in ACR with a decrease in creatinine clearance by 0.032 mL/min.	Creatinine	219-229	acrosin	Homo sapiens	140-143
31076148-7	2019	RESULTS: With multivariate linear regression, the latest estimated glomerular filtration rate has a strong linear relationship with initial ACR (B = -0.032; P = .02), suggesting each unit rise in ACR with a decrease in creatinine clearance by 0.032 mL/min.	Creatinine	219-229	acrosin	Homo sapiens	196-199
31076148-10	2019	The area under ACR curve is 0.825, better than above parameters, and only second to serum creatinine level.	Creatinine	90-100	acrosin	Homo sapiens	15-18
30864839-7	2019	Finally, we detected podoplanin in the urine of mice after ischemia, and we observed that an increase in the urine podoplanin-to-creatinine ratio correlated strongly with the onset of renal ischemia-reperfusion injury.	Creatinine	129-139	podoplanin	Mus musculus	21-31
30864839-7	2019	Finally, we detected podoplanin in the urine of mice after ischemia, and we observed that an increase in the urine podoplanin-to-creatinine ratio correlated strongly with the onset of renal ischemia-reperfusion injury.	Creatinine	129-139	podoplanin	Mus musculus	115-125
30299250-7	2019	After MRL/lpr mice were treated with anti-IL-22 monoclonal antibody (mAb) for 12 weeks, significantly less urine protein and lower serum levels of creatinine and urea nitrogen were found.	Creatinine	147-157	interleukin 22	Mus musculus	42-47
31023272-7	2019	Urinary monocyte chemoattractant protein-1 was also significantly lower in the propolis group than in the placebo group-58 pg/mg creatinine (95% CI, 36 to 95) vs. 98 pg/mg creatinine (95% CI, 62 to 155); P = 0.038.	Creatinine	129-139	C-C motif chemokine ligand 2	Homo sapiens	8-42
31258944-9	2019	Results: The baseline urinary MCP-1 levels in female patients with OAB were significantly higher than those of the controls, at a mean of 210.25 vs 48.02 pg/mg Cr (P &lt; 0.001).	Creatinine	160-162	C-C motif chemokine ligand 2	Homo sapiens	30-35
30672316-7	2019	A lack of PAR2 corrected the levels of plasma blood urea nitrogen and creatinine as well as ameliorated the acute tubular injury score in the kidney.	Creatinine	70-80	coagulation factor II (thrombin) receptor-like 1	Mus musculus	10-14
30477733-7	2019	Moreover, in large prospective cardiovascular outcome trials using composite renal outcomes as secondary endpoints, both GLP-1RAs and SGLT2is added to standard care reduced renal outcomes combining persistent macro-albuminuria, doubling of serum creatinine, progression to ESRD and kidney-related death; however, to date, only SGLT2is have been clearly shown to reduce such hard clinical outcomes.	Creatinine	246-256	solute carrier family 5 member 2	Homo sapiens	134-139
30781721-6	2019	OPN levels were positively correlated to plasma creatinine (r = 0.401 with p = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients.	Creatinine	48-58	secreted phosphoprotein 1	Homo sapiens	0-3
30677083-10	2019	Urinary EGF was positively correlated with serum magnesium (r = 0.583; p&lt;0.001) and creatinine clearance (r = 0.524; p&lt;0.001) and negatively correlated with the fractional excretion of magnesium (r = 0.248; p = 0.014).	Creatinine	87-97	epidermal growth factor	Homo sapiens	8-11
30697570-7	2019	Baseline and study levels of RBP-4 and beta2M were higher for patients with increases in urine proteinuria and an absolute creatinine increase.	Creatinine	123-133	beta-2-microglobulin	Homo sapiens	39-45
31389491-5	2019	D/P creatinine differed between t-PET and mini-PET (P&lt;0.001) and between mod-PET and mini-PET (P&lt;0.01) but not between t-PET and mod-PET (P=0.746).	Creatinine	4-14	T-box transcription factor 21	Homo sapiens	32-37
31389491-6	2019	The correlation of D/P creatinine with t-PET vs mod-PET was significant (r=0.387, P=0.009) but not that of t-PET vs mini-PET (r=0.088, P=0.241).	Creatinine	23-33	T-box transcription factor 21	Homo sapiens	39-44
31389491-11	2019	The significant correlation of D/P creatinine between t-PET and mod-PET suggested that the latter is a good alternative to t-PET.	Creatinine	35-45	T-box transcription factor 21	Homo sapiens	54-59
31336472-8	2019	Serum leptin showed significant positive correlations with diabetes duration (r = 0.188, P = 0.020), glucose (r = 0.298, P < 0.001), cholesterol (r = 0.323, P < 0.001), triglycerides (r = 0.361, P < 0.001), LDL-C (r = 0.248, P = 0.001) and urinary albumin (r = 0.256, P = 0.001) whereas negative significant correlations were found with HDL-C (r = -0.313, P < 0.001) and urinary creatinine (r = -0.202, P = 0.007).	Creatinine	379-389	leptin	Homo sapiens	6-12
31519530-8	2019	Only IL-6, ferritin and serum creatinine correlate significantly with serum hepcidin from seven variables that were previously eligible to enter the analysis.	Creatinine	30-40	hepcidin antimicrobial peptide	Homo sapiens	76-84
31519530-9	2019	This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine).	Creatinine	85-95	hepcidin antimicrobial peptide	Homo sapiens	42-50
31519530-9	2019	This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine).	Creatinine	85-95	hepcidin antimicrobial peptide	Homo sapiens	109-117
31519530-9	2019	This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine).	Creatinine	180-190	hepcidin antimicrobial peptide	Homo sapiens	42-50
31519530-9	2019	This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine).	Creatinine	180-190	hepcidin antimicrobial peptide	Homo sapiens	109-117
31519530-10	2019	CONCLUSION: This study has revealed that the creatinine level, ferritin and IL-6 can be used to predict the hepcidin level in patients with anemia of chronic disease.	Creatinine	45-55	hepcidin antimicrobial peptide	Homo sapiens	108-116
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Creatinine	112-122	beta-2-microglobulin	Homo sapiens	34-54
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Creatinine	156-166	beta-2-microglobulin	Homo sapiens	34-54
30476640-9	2019	Also, patients with ST depression in aVR >= 1 mm showed significantly higher cardiac enzyme levels, indicating larger infarct size, with mean peak creatinine kinase (CK) = 1560 (1057-2375) IU/L versus 970 (613-1683) IU/L, (P value = 0.014), lower ejection fraction (Ef) with mean Ef = 47.93 +- 8.04 versus 54.66 +- 6.52, (P value < 0.001) and more significant mitral regurgitation: 17 (41.5%) patients versus 11 (18.6%) patients (P value = 0.012).	Creatinine	147-157	NLR family pyrin domain containing 6	Homo sapiens	37-40
30127486-5	2018	The level of miR-29a was negatively correlated with the glomerular filtration rate, but was positively correlated with C-reactive protein, TGF-beta1, and the urinary albumin to creatinine ratio (UACR).	Creatinine	177-187	microRNA 29a	Homo sapiens	13-20
29707997-10	2018	Linear regression analysis demonstrated that HO-1 was the independent predictor of AKI demonstrated by elevated creatinine among GI and GII.	Creatinine	112-122	heme oxygenase 1	Homo sapiens	45-49
30130540-11	2018	In vivo experiments showed that HOTAIR negatively modulated miR-22 and positively modulated HMGB1 and that HOTAIR knockdown decreased renal function indicators (blood urea nitrogen [BUN] and serum creatinine).	Creatinine	197-207	HOX transcript antisense RNA	Homo sapiens	107-113
30246878-18	2018	SGLT2 inhibitors may reduce weight (5 studies, 1029 participants: MD -1.41 kg, -1.8 to -1.02; I2 = 28%) and albuminuria (MD -8.14 mg/mmol creatinine, -14.51 to -1.77; I2 = 11%; low certainty evidence).	Creatinine	138-148	solute carrier family 5 member 2	Homo sapiens	0-5
30246878-30	2018	Additionally, SGLT2 inhibitors probably reduce BP, heart failure, and hyperkalaemia but increase genital infections, and slightly increase creatinine.	Creatinine	139-149	solute carrier family 5 member 2	Homo sapiens	14-19
30294350-7	2018	Conclusion: Our data suggest that serum B2M concentration may be individually associated with MACEs and all-cause death in elderly ISH patients without severe renal insufficiency even after adjusted for creatinine-eGFR and cystatin C.	Creatinine	203-213	beta-2-microglobulin	Homo sapiens	40-43
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Creatinine	253-263	erythropoietin	Rattus norvegicus	24-27
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Creatinine	265-269	erythropoietin	Rattus norvegicus	24-27
30212493-1	2018	BACKGROUND: Limiting the contrast volume to creatinine clearance (V/CrCl) ratio is crucial for preventing contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI).	Creatinine	44-54	CRCL	Homo sapiens	68-72
29939350-10	2018	Serum creatinine levels showed a linear decrease with increasing SID Lys:CP levels (P < 0.001).	Creatinine	6-16	ceruloplasmin	Homo sapiens	73-75
30114399-10	2018	Additionally, there was a negative correlation between their urinary OPN (ng/mL) and serum creatinine (mg/dL) levels of female patients (p&lt;0.05).	Creatinine	91-101	secreted phosphoprotein 1	Homo sapiens	69-72
29441476-5	2018	RESULTS: Augmented renal clearance, defined as a creatinine clearance (CrCl) &gt; 130 mL/min/1.73 m2, preferably measured in urine, is present in 20-65% of critically ill patients.	Creatinine	49-59	CRCL	Homo sapiens	71-75
30230985-8	2018	Serum MCP-1 levels in systemic vasculitis patients were positively correlated with serum creatinine levels (r = 0.387, P < 0.010) and with 24-h proteinuria (r = 0.404, P < 0.014).	Creatinine	89-99	C-C motif chemokine ligand 2	Homo sapiens	6-11
29707088-1	2018	Background: We examined whether the sodium-glucose cotransporter-2 inhibitor (SGLT2i) dapagliflozin can improve urine albumin-to-creatinine ratio (UACR) associated with a reduction in body weight or body fat in patients with type 2 diabetes mellitus (T2DM).	Creatinine	129-139	solute carrier family 5 member 2	Homo sapiens	36-66
30364869-6	2018	Dosing of each DOAC was assessed at therapy initiation and throughout treatment whenever a serum creatinine was reported, using the Cockcroft-Gault equation to estimate creatinine clearance (CrCl).	Creatinine	169-179	CRCL	Homo sapiens	191-195
29741162-10	2018	CONCLUSIONS The urinary sarcosine/creatinine ratio was a diagnostic indicator of prostate cancer, for patients with a serum PSA level &lt;10 ng/ml, and correlated with the Gleason score and with the presence of metastases (stage) of prostate cancer.	Creatinine	34-44	kallikrein related peptidase 3	Homo sapiens	124-127
29723250-8	2018	SET7/9 expression was positively correlated with dialysate/plasma ratio of creatinine in PD patients.	Creatinine	75-85	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
29635893-10	2018	Moreover, suppression of miR-30b alleviated the LPS-induced kidney injury in mice model by decreasing creatinine level, ALT activity and histologic scores, as well as concentrations of inflammatory cytokines.	Creatinine	102-112	microRNA 30b	Mus musculus	25-32
29097070-9	2018	Creatinine clearance (CrCl) estimated via the Cockcroft-Gault equation significantly impacted CL and total daily dose.	Creatinine	0-10	CRCL	Homo sapiens	22-26
29723981-7	2018	Kidney pathology reflected by urinary &amp;beta;2-microglobulin (&amp;beta;2-MG) levels &amp;ge; 300 &amp;mu;g/g creatinine showed an association with 5.32-fold increase in prevalence odds of CKD (p = 0.001), while urinary Cd levels showed an association with a 2.98-fold greater odds of CKD prevalence (p = 0.037).	Creatinine	113-123	beta-2-microglobulin	Homo sapiens	43-63
29704936-13	2018	In non-pedigree cats, one synonymous SNP CaSR:c.1269G&gt;A was associated with logPTH concentration (adjusted for plasma creatinine concentration), with a recessive model having the best fit (G/G vs A/A-G/A, P=0.031).	Creatinine	121-131	calcium sensing receptor	Felis catus	41-45
29674665-3	2018	alpha7nAChR activation reduced plasma creatinine levels and tubular cell damage, whereas alpha7nAChR inhibition aggravated the IR-induced phenotype.	Creatinine	38-48	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	0-11
29662003-9	2018	The PPAR system thus offers an important hope in the management of atherogenic dyslipidemias, although concerns regarding potential adverse events such as the rise of plasma creatinine, gallstone formation, drug-drug interactions (i.e., gemfibrozil) and myopathy should also be acknowledged.	Creatinine	174-184	peroxisome proliferator activated receptor alpha	Homo sapiens	4-8
29222368-4	2018	The functional role of Erbb4-IR in T2DN was revealed by kidney-specific silencing of Erbb4-IR to protect against the development of T2DN, such as elevated microalbuminuria, serum creatinine, and progressive renal fibrosis in db/db mice, and to block AGE-induced collagen I and IV expression in mouse mesangial cells (mMCs) and mouse tubular epithelial cells (mTECs).	Creatinine	179-189	erb-b2 receptor tyrosine kinase 4	Mus musculus	23-28
29222368-4	2018	The functional role of Erbb4-IR in T2DN was revealed by kidney-specific silencing of Erbb4-IR to protect against the development of T2DN, such as elevated microalbuminuria, serum creatinine, and progressive renal fibrosis in db/db mice, and to block AGE-induced collagen I and IV expression in mouse mesangial cells (mMCs) and mouse tubular epithelial cells (mTECs).	Creatinine	179-189	erb-b2 receptor tyrosine kinase 4	Mus musculus	85-90
29355653-3	2018	Outcome is worsening of urinary albumin-to-creatinine(ACR) across stages.	Creatinine	43-53	acrosin	Homo sapiens	54-57
29581733-8	2018	In addition, there was a negative correlation between the expression of sirt3 and 24 h urinary protein excretion, serum creatinine levels, tubulointerstitial mononuclear cell infiltration, smooth muscle cell migration in the vascular wall and Banff scores.	Creatinine	120-130	sirtuin 3	Rattus norvegicus	72-77
29523295-8	2018	SNORD115-TAF1 and SNORD-DPM2 dysfunction introduce possible clues to the parkinsonism and increased creatinine phosphokinase in NMS, while abnormalities of SNORD115-RALGPS1 suggest links to both anti-NMDAR encephalitis and the proven predisposing catatonic SHANK3 gene.	Creatinine	100-110	small nucleolar RNA, C/D box 115 cluster	Homo sapiens	0-8
28534527-6	2018	A 39-fold decrease (P&lt;0.0001) in the levels of creatinine-adjusted urinary 17beta-DHE-Gluc was observed among UGT2B17 (*2/*2) subjects vs subjects with the UGT2B17 (*1/*1) genotype.	Creatinine	50-60	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	113-120
28534527-6	2018	A 39-fold decrease (P&lt;0.0001) in the levels of creatinine-adjusted urinary 17beta-DHE-Gluc was observed among UGT2B17 (*2/*2) subjects vs subjects with the UGT2B17 (*1/*1) genotype.	Creatinine	50-60	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	159-166
29115389-6	2018	EPO downregulated the expression of interferon-gamma, interleukin (IL)-4, creatinine and caspase-3, and upregulated the expression of IL-10, thymic stromal lymphopoietin, STAT6, p-JNK and p-p38, while the opposite effects were observed with the administration of EPO-siRNA and the specific respective inhibitors.	Creatinine	74-84	erythropoietin	Rattus norvegicus	0-3
29122448-5	2018	RESULTS: Upper quartile TNFR1 is independently associated with elevated urinary albumin-creatinine ratios, reductions in eGFR and strongly predicts the presence of stages 3-5 chronic kidney disease in regression modelling.	Creatinine	88-98	TNF receptor superfamily member 1A	Homo sapiens	24-29
29466798-13	2018	After multivariable analysis, ATIII activity &lt;75% remained a significant independent predictor of CIN (OR 2.207,95%CI [1.29-3.777]; P=0.004) as well as baseline serum creatinine (OR 1.009,95%CI [1.001-1.016]; P=0.026).	Creatinine	170-180	serpin family C member 1	Homo sapiens	30-35
28873373-5	2018	Among 67 patients with MDRD &lt;60, only urinary epidermal growth factor was different comparing AKI (increase in serum creatinine &gt;=0.3 mg/dL from baseline within past 3 months) vs. no AKI (2,254 vs. 4,253, p = 0.003).	Creatinine	120-130	epidermal growth factor	Homo sapiens	49-72
28731906-9	2018	Treatment with C1-INH also improved renal function and reduced renal injury, reflected by the significantly lower kidney injury marker 1 gene expression and lower serum levels of lactate dehydrogenase and creatinine.	Creatinine	205-215	serpin family G member 1	Rattus norvegicus	15-21
31618189-9	2017	The initial creatinine value doubled in 29 (63%) patients undergoing NAC+COL therapy and in 27 (58.7%) patients in the COL group (p = 0.669).	Creatinine	12-22	synuclein alpha	Homo sapiens	69-76
31618189-10	2017	The median doubling time of baseline creatinine was 6 and 7 days in the NAC+COL and COL groups, respectively.	Creatinine	37-47	synuclein alpha	Homo sapiens	72-79
28992939-8	2017	Among all filtration markers, B2M had the strongest association with incident PAD (HR for top vs. bottom quartile 2.60 [95% CI: 1.91-3.54] for B2M vs. 1.20 [0.91-1.58] for creatinine-based eGFR).	Creatinine	172-182	beta-2-microglobulin	Homo sapiens	30-33
28601698-5	2017	We evaluated associations of high TNFR1 with baseline estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) and with longitudinal changes in eGFR (rapid loss), as well as with incident myocardial infarction (MI), heart failure hospitalizations (HF), and mortality over a median follow-up time of 8.9 years.	Creatinine	119-129	TNF receptor superfamily member 1A	Homo sapiens	34-39
28188048-5	2017	RESULTS: LEPR expression was significantly correlated with patients with increased body mass index (P &lt; .001) and high serum creatinine levels (P = .005).	Creatinine	128-138	leptin receptor	Homo sapiens	9-13
28430696-14	2017	While serum creatinine fell at 12 hours, serum cystatin C increased, suggestive of decreased creatinine production.	Creatinine	93-103	cystatin C	Rattus norvegicus	47-57
28337529-10	2017	In 14 patients (25%), we observed increased creatinine levels of CTC 1  or 2 .	Creatinine	44-54	CST telomere replication complex component 1	Homo sapiens	65-70
26807589-7	2016	The levels of beta2-microglobulin in urine and creatinine (Cr) were measured.	Creatinine	59-61	beta-2-microglobulin	Homo sapiens	14-33
26882829-1	2016	OBJECTIVE: to analyze the effect of the modifications in the Cockcroft-Gault equation for creatinine clearance rate determination (CrCl) and its concordance with the real value determined from 24-hours urine collection in a sample of Latin American patients hospitalized in San Jose de Costa Rica.	Creatinine	90-100	CRCL	Homo sapiens	131-135
26462810-8	2016	Additionally, while hepcidin-20 was strongly correlated with serum creatinine, the other isoforms were not.	Creatinine	67-77	hepcidin antimicrobial peptide	Homo sapiens	20-28
27296256-10	2016	Clusterin, MCP-1 and KIM-1 positively and significantly correlated with serum creatinine at the week following the determination of BMs in the multivariate linear regression models adjusted for other confounders.	Creatinine	78-88	C-C motif chemokine ligand 2	Homo sapiens	11-16
28387939-8	2017	Creatinine clearance(CLCR ) and lean body mass (LBM) were identified as significant predictors of veliparib CLR /F and central volume of distribution, respectively.	Creatinine	0-10	doublecortin like kinase 3	Homo sapiens	108-111
28229280-7	2017	In the correlation analysis, beta2-microglobulin positively correlated with the presence of MCP-1/CCL2, sTNFRI and eotaxin/CCL11 and negatively correlated with the presence of creatinine.	Creatinine	176-186	beta-2-microglobulin	Homo sapiens	29-48
28469165-3	2017	Compared with littermate of wildtype (WT) mice in which induced severe crescentic GN developed with progressive renal dysfunction, Foxp3 Tg mice had reduced crescent formation, urinary protein excretion, plasma creatinine and decline in creatinine clearance.	Creatinine	211-221	forkhead box P3	Mus musculus	131-136
28469165-3	2017	Compared with littermate of wildtype (WT) mice in which induced severe crescentic GN developed with progressive renal dysfunction, Foxp3 Tg mice had reduced crescent formation, urinary protein excretion, plasma creatinine and decline in creatinine clearance.	Creatinine	237-247	forkhead box P3	Mus musculus	131-136
28188955-8	2017	The number of cells per milligram of creatinine was significantly positively correlated with expression of all three mRNAs with correlation coefficients (R-value) of 0.442, 0.481, and 0.561 for Pod-, Nep-, and AQP2-mRNA, respectively.	Creatinine	37-47	aquaporin 2	Homo sapiens	210-214
28069720-7	2017	Because creatinine is also a substrate of OCT2, MATE1, and MATE2-K, creatinine clearance likely overestimates filtration clearance, whereas the calculated 1-NMN secretion clearance is likely underestimated.	Creatinine	8-18	solute carrier family 22 member 2	Homo sapiens	42-46
27979705-8	2017	On univariate analysis, c-IMT was significantly correlated with eGFR (r = -0.33; p &lt; 0.001), serum creatinine (r = 0.17; p &lt; 0.001), and other variables such as age, systolic blood pressure, waist circumference, fasting or random glycemia, and glycated hemoglobin (HbA1c).	Creatinine	102-112	CIMT	Homo sapiens	24-29
27979705-9	2017	On multiple regression analysis, serum creatinine was associated with c-IMT (beta = 0.069; p = 0.017), independent of other covariates.	Creatinine	39-49	CIMT	Homo sapiens	70-75
28038936-6	2017	Significant positive correlations were found between circulating nesfatin-1 levels and the following case-mix variables: duration of diabetes, glycated hemoglobin, plasma creatinine, UAE and serum uric acid.	Creatinine	171-181	nucleobindin 2	Homo sapiens	65-75
28124825-4	2017	The photoactivated hydride involved was characterized spectroscopically and the resulting [Cp2 *RuIII ]+ species was electrochemically regenerated in situ on a fluorinated tin oxide electrode surface.	Creatinine	19-26	ceruloplasmin	Homo sapiens	91-94
26701957-1	2017	Objectives The aim of the study was to evaluate whether a handheld creatinine analyser (StatSensor Xpress; SSXp), available for human patients, can be used to measure creatinine reliably in cats.	Creatinine	67-77	SSX family member 2B	Homo sapiens	107-111
26188109-1	2015	Relationships between the plasma concentration of a cathepsin K inhibitor (ONO-5334) and inhibition of bone resorption markers N-telopeptide of type I collagen (NTX) and C-telopeptide of type I collagen (CTX) in serum and urinary NTX/creatinine and CTX/creatinine were examined in 10 postmenopausal women.	Creatinine	234-244	cathepsin K	Homo sapiens	52-63
26188109-1	2015	Relationships between the plasma concentration of a cathepsin K inhibitor (ONO-5334) and inhibition of bone resorption markers N-telopeptide of type I collagen (NTX) and C-telopeptide of type I collagen (CTX) in serum and urinary NTX/creatinine and CTX/creatinine were examined in 10 postmenopausal women.	Creatinine	253-263	cathepsin K	Homo sapiens	52-63
26701957-1	2017	Objectives The aim of the study was to evaluate whether a handheld creatinine analyser (StatSensor Xpress; SSXp), available for human patients, can be used to measure creatinine reliably in cats.	Creatinine	167-177	SSX family member 2B	Homo sapiens	107-111
27932282-9	2017	Regression analysis found that serum cTnI concentrations decreased with increasing time from collapse (p=0.015) and increased with increasing creatinine concentration (p=0.028).	Creatinine	142-152	troponin I3, cardiac type	Canis lupus familiaris	37-41
26713989-5	2015	Urine renalase/creatinine values were negatively related to serum creatinine and positively related to glomerular filtration rate.	Creatinine	66-76	renalase, FAD dependent amine oxidase	Homo sapiens	6-14
26837248-8	2015	RESULTS: (1) On PID 1, the levels of urea nitrogen and creatinine were (9.0 +- 3.2) mmol/L and (115 +- 24) micromol/L respectively, which were obviously higher than normal values (with the values of 2.9-8.2 mmol/L and 45-104 micromol/L respectively).	Creatinine	55-65	phosphotyrosine interaction domain containing 1	Homo sapiens	16-21
26837248-11	2015	On PID 3, 5, 7 and 14, the levels of creatinine were (248 +- 67), (224 +- 87), (276 +- 59) and (307 +- 77) micromol/L respectively, which were obviously higher than the value of PID 1 (with t values 4.17, 2.70, 5.65 and 5.32 respectively, P values below 0.01).	Creatinine	37-47	phosphotyrosine interaction domain containing 1	Homo sapiens	178-183
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	insulin like growth factor binding protein 1	Homo sapiens	0-6
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	insulin like growth factor binding protein 3	Homo sapiens	8-52
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	insulin like growth factor binding protein 3	Homo sapiens	54-60
28596840-5	2017	The pronounced changes in serum creatinine were accompanied by increased urinary excretion of beta-2-microglobulin and KIM1.	Creatinine	32-42	beta-2-microglobulin	Homo sapiens	94-114
27867039-7	2017	PD effluent miR-21 and miR-589 levels correlated with dialysate-to-plasma creatinine concentration at 4h (D/P4) at baseline (r=0.377, p=0.001 and r=0.237, p=0.037, respectively) and after one year of PD (r=0.362, p=0.014 and r=0.402, p=0.007).	Creatinine	74-84	microRNA 21	Homo sapiens	12-18
26493883-1	2015	We report that 2,6-lutidine trichloroborane (Lut BCl3 ) reacts with H2 in toluene, bromobenzene, dichloromethane, and Lut solvents producing the neutral hydride, Lut BHCl2 .	Creatinine	153-160	BCL3 transcription coactivator	Homo sapiens	49-53
26113475-7	2015	While Ucn2 and dobutamine increased creatinine clearance and urine volume similarly, only Ucn2 induced a significant natriuresis.	Creatinine	36-46	urocortin-2	Ovis aries	6-10
25968430-9	2015	In addition, cIMT had a significant correlation with waist circumference, waist/height ratio, albumin/ creatinine ratio, total cholesterol, and triglyceride.	Creatinine	103-113	CIMT	Homo sapiens	13-17
27867039-7	2017	PD effluent miR-21 and miR-589 levels correlated with dialysate-to-plasma creatinine concentration at 4h (D/P4) at baseline (r=0.377, p=0.001 and r=0.237, p=0.037, respectively) and after one year of PD (r=0.362, p=0.014 and r=0.402, p=0.007).	Creatinine	74-84	microRNA 589	Homo sapiens	23-30
27888806-6	2016	DACH1 staining in the glomerulus correlated positively with eGFR (r = 0.41, p &lt; 0.001) but negatively with serum creatinine (r = -0.37, p &lt; 0.01).	Creatinine	116-126	dachshund family transcription factor 1	Homo sapiens	0-5
26345643-5	2015	Furthermore, EVG/c/FTC/TDF exhibited an excellent tolerability profile, with a safer lipid profile, and despite the indication of its use in subjects with an estimated creatinine clearance &gt;70 mL/min, recent data demonstrated that EVG/c/FTC/TDF determined a reduction in estimated glomerular filtration rate (GFR) but not a reduction of actual GFR.	Creatinine	168-178	sex determining region Y	Homo sapiens	23-26
26108072-9	2015	RESULTS: The geometric mean (95% confidence interval [CI]) creatinine-adjusted urine CC16 level was, for creatinine, 9.77 ng/mg (95% CI, 8.12-12.02 ng/mg).	Creatinine	59-69	secretoglobin family 1A member 1	Homo sapiens	85-89
26108072-9	2015	RESULTS: The geometric mean (95% confidence interval [CI]) creatinine-adjusted urine CC16 level was, for creatinine, 9.77 ng/mg (95% CI, 8.12-12.02 ng/mg).	Creatinine	105-115	secretoglobin family 1A member 1	Homo sapiens	85-89
27992535-4	2016	Moreover, urine OPN N-half was higher in LN patients with overt proteinuria (urine protein/creatinine ratio: P/C &gt; 0.5) than LN patients with minimal proteinuria (P/C &lt; 0.5, p &lt; 0.0001), and also higher than in DN patients with overt proteinuria (P/C &gt; 0.5, p &lt; 0.01).	Creatinine	91-101	secreted phosphoprotein 1	Homo sapiens	16-19
26119851-6	2015	A higher frequency of beta2-microglobulin proteinuria (beta2-microglobulin-creatinine ratio &gt;0.68mg/g) was also observed in the tenofovir group (28.9%) compared to the non-tenofovir group (13.6%, p=0.024).	Creatinine	75-85	beta-2-microglobulin	Homo sapiens	22-41
26119851-6	2015	A higher frequency of beta2-microglobulin proteinuria (beta2-microglobulin-creatinine ratio &gt;0.68mg/g) was also observed in the tenofovir group (28.9%) compared to the non-tenofovir group (13.6%, p=0.024).	Creatinine	75-85	beta-2-microglobulin	Homo sapiens	55-74
27533906-1	2016	BACKGROUND: An accurate assessment of creatinine clearance (CrCl) is essential when dosing medications in critically ill trauma patients.	Creatinine	38-48	CRCL	Homo sapiens	60-64
27589683-8	2016	HE4 can be a predictor of renal fibrosis in CKD patients; the area under the receiver-operating characteristic curve (AUC-ROC) was 0.99, higher than the AUC-ROC of serum creatinine (0.89).	Creatinine	170-180	WAP four-disulfide core domain 2	Homo sapiens	0-3
26018205-8	2015	MiR192 increased 8h after acute liver failure (P&lt;0.0001) and was associated with increasing creatinine (P&lt;0.0001).	Creatinine	95-105	microRNA 192	Sus scrofa	0-6
25615414-7	2015	In DM patients, U-Trx was negatively correlated with eGFR, especially in males, and positively correlated with UP/Cr and NAG in both sexes (all P &lt; 0.01), as well as with systolic blood pressure in all (P &lt; 0.05).	Creatinine	114-116	thioredoxin	Homo sapiens	18-21
26022021-12	2015	Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance.	Creatinine	84-94	C-C motif chemokine ligand 2	Homo sapiens	8-13
26022021-12	2015	Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance.	Creatinine	130-140	C-C motif chemokine ligand 2	Homo sapiens	8-13
27216597-3	2016	We hypothesized that urinary nephrin-to-creatinine ratio can be up-regulated and is negatively correlated with renal nephrin mRNA levels in animal models of kidney disease, and that increased urinary nephrin-to-creatinine ratio levels are attenuated following administration of glucocorticoids.	Creatinine	40-50	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	29-36
27216597-3	2016	We hypothesized that urinary nephrin-to-creatinine ratio can be up-regulated and is negatively correlated with renal nephrin mRNA levels in animal models of kidney disease, and that increased urinary nephrin-to-creatinine ratio levels are attenuated following administration of glucocorticoids.	Creatinine	40-50	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	117-124
27216597-3	2016	We hypothesized that urinary nephrin-to-creatinine ratio can be up-regulated and is negatively correlated with renal nephrin mRNA levels in animal models of kidney disease, and that increased urinary nephrin-to-creatinine ratio levels are attenuated following administration of glucocorticoids.	Creatinine	40-50	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	117-124
27216597-3	2016	We hypothesized that urinary nephrin-to-creatinine ratio can be up-regulated and is negatively correlated with renal nephrin mRNA levels in animal models of kidney disease, and that increased urinary nephrin-to-creatinine ratio levels are attenuated following administration of glucocorticoids.	Creatinine	211-221	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	29-36
27216597-7	2016	Urinary nephrin-to-creatinine ratio exhibited a significant negative correlation with renal nephrin mRNA in almost all models, as well as a significant positive correlation with urinary protein-to-creatinine ratio and a significant negative correlation with creatinine clearance ratio.	Creatinine	19-29	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	8-15
27216597-7	2016	Urinary nephrin-to-creatinine ratio exhibited a significant negative correlation with renal nephrin mRNA in almost all models, as well as a significant positive correlation with urinary protein-to-creatinine ratio and a significant negative correlation with creatinine clearance ratio.	Creatinine	19-29	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	92-99
27216597-7	2016	Urinary nephrin-to-creatinine ratio exhibited a significant negative correlation with renal nephrin mRNA in almost all models, as well as a significant positive correlation with urinary protein-to-creatinine ratio and a significant negative correlation with creatinine clearance ratio.	Creatinine	197-207	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	8-15
27216597-7	2016	Urinary nephrin-to-creatinine ratio exhibited a significant negative correlation with renal nephrin mRNA in almost all models, as well as a significant positive correlation with urinary protein-to-creatinine ratio and a significant negative correlation with creatinine clearance ratio.	Creatinine	197-207	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	8-15
27216597-8	2016	Urinary protein-to-creatinine ratio exhibited a significant negative correlation with renal nephrin mRNA.	Creatinine	19-29	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	92-99
27216597-9	2016	Following the administration of prednisolone to puromycin aminonucleoside (single injection) nephropathy rats, urinary nephrin-to-creatinine ratio was significantly suppressed and exhibited a significant positive correlation with urinary protein-to-creatinine ratio.	Creatinine	130-140	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	119-126
27216597-9	2016	Following the administration of prednisolone to puromycin aminonucleoside (single injection) nephropathy rats, urinary nephrin-to-creatinine ratio was significantly suppressed and exhibited a significant positive correlation with urinary protein-to-creatinine ratio.	Creatinine	249-259	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	119-126
27216597-10	2016	In addition, the decrease in number of glomerular Wilms tumor antigen-1-positive cells was attenuated, and urinary nephrin-to-creatinine ratio exhibited a significant negative correlation in these cells.	Creatinine	126-136	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	115-122
27216597-11	2016	In conclusion, these results suggest that urinary nephrin-to-creatinine ratio level is a useful and reliable biomarker for predicting the amelioration of podocyte dysfunction by candidate drugs in various kidney disease models with podocyte dysfunction.	Creatinine	61-71	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	50-57
27056296-8	2016	In-depth analysis of two selected pathways revealed a significant increase in plasma urea level correlating with increased renal Arginase II activity, hyperargininemia, and increased kidney arginine content as well as a significant increase in plasma creatinine concentration and a reduced capacity of the kidney to secrete anionic drugs (furosemide) paralleled by an approximate 80% decrease in the expression level of organic anion transporter 3 (SLC22a8).	Creatinine	251-261	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	449-456
27189318-8	2016	C statistic for traditional predictors of eGFR decline was 0.70, which improved significantly to 0.74 with monocyte chemotactic protein-1-to-creatinine ratio.	Creatinine	141-151	C-C motif chemokine ligand 2	Homo sapiens	107-137
27189318-9	2016	CONCLUSIONS: Urinary monocyte chemotactic protein-1-to-creatinine ratio concentrations were strongly associated with sustained renal decline in patients with type 2 diabetes with preserved renal function.	Creatinine	55-65	C-C motif chemokine ligand 2	Homo sapiens	21-51
27531787-3	2016	METHODS: The activity of ADAMTS13 in patient groups (atherosclerosis, diabetes, acute promyelocytic leukemia, cancer and sepsis, a total of 260 cases) and in control group 50 cases were evaluated by residue collagen binding assay(R-CBA), the protein levels of TSP1 and vWF were measured by ELISA kits; the correlation of ADAMTS13 activity with CRP, creatinine, and blood pressure was analyzed with statistical soft ware.	Creatinine	349-359	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	25-33
27531787-6	2016	Analysis of the correlation showed that the ADAMTS13 activity correlated negatively with the levels of TSP1 protein, blood sugar, blood pressure, D-dimer, creatinine,and CRP levels (P&lt;0.05), however, the ADAMTS13 activity did not significantly correlate with the levels of serum lipids, blood type, platelet number and hemoglobin level(P&gt;0.05).	Creatinine	155-165	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	44-52
27351287-6	2016	Notably, miR-27a exhibited clinical and biological relevance as it was linked to elevated serum creatinine, proteinuria, urinary N-acetyl-beta-D-glucosaminidase (NAG), and reduced estimated glomerular filtration rate (eGFR).	Creatinine	96-106	microRNA 27a	Rattus norvegicus	9-16
27103565-4	2016	RESULTS: Urine AQP5/creatinine 1) is significantly higher in diabetic nephropathy than in other two groups, and in diabetic nephropathy stage V than in stage III; 2) correlates with serum creatinine, urine albumin, and multiple other known risk factors of the disease; and 3) improves the clinical models in distinguishing diabetic nephropathy from normal controls and diabetic mellitus.	Creatinine	20-30	aquaporin 5	Homo sapiens	15-19
27103565-4	2016	RESULTS: Urine AQP5/creatinine 1) is significantly higher in diabetic nephropathy than in other two groups, and in diabetic nephropathy stage V than in stage III; 2) correlates with serum creatinine, urine albumin, and multiple other known risk factors of the disease; and 3) improves the clinical models in distinguishing diabetic nephropathy from normal controls and diabetic mellitus.	Creatinine	188-198	aquaporin 5	Homo sapiens	15-19
27103565-5	2016	CONCLUSION: Our data suggest that urine AQP5/creatinine may possess diagnostic and prognostic values as a biomarker of diabetic nephropathy.	Creatinine	45-55	aquaporin 5	Homo sapiens	40-44
26616141-9	2016	Following EPO application, there was only a statistically non-significant tendency of serum creatinine and urea to improve, particularly after daily EPO application.	Creatinine	92-102	erythropoietin	Rattus norvegicus	10-13
25860248-6	2015	Serum TNFR levels were positively correlated with the urinary protein to creatinine ratio (UPCR) and four markers of tubular damage of interest (N-acetyl-beta-D-glucosaminidase [NAG], beta2 microglobulin [beta2m], liver-type fatty acid-binding protein [L-FABP], and kidney injury molecule-1 [KIM-1]) and negatively correlated with estimated glomerular filtration rate (eGFR).	Creatinine	73-83	TNF receptor superfamily member 1A	Homo sapiens	6-10
25145934-8	2015	In American-Indian patients with diabetic nephropathy (n=48), albumin-to-creatinine ratio was positively associated with miR-21 expression in glomerular fractions (r=0.6; P&lt;0.001) but not tubulointerstitial fractions (P=0.80).	Creatinine	73-83	microRNA 21	Homo sapiens	121-127
25145934-11	2015	The aggravation of glomerular disease in miR-21-deficient mice and the positive association with albumin-to-creatinine ratio in patients with diabetic nephropathy support miR-21 as a feedback inhibitor of TGF-beta signaling and functions.	Creatinine	108-118	microRNA 21	Homo sapiens	171-177
25877353-5	2015	The number of CD14+TLR4+ monocytes was positively correlated with estimated glomerular filtration rate (eGFR, P&lt;0.001) and the levels of hematocrit (P&lt;0.01), but negatively correlated with the levels of blood urine nitrogen, serum creatinine, and C-reactive protein (P&lt;0.001 for all), in the CKD patients.	Creatinine	237-247	toll like receptor 4	Homo sapiens	19-23
26109997-7	2015	CIMT also correlated with age, duration of diabetes, systolic blood pressure, blood urea nitrogen, and serum creatinine.	Creatinine	109-119	CIMT	Homo sapiens	0-4
25273515-13	2015	Creatinine clearance (CrCl) was found to have a negative correlation with PRx (Pearson correlation--0.82), with statistically significant crude (p &lt; 0.001) and adjusted (p = 0.001) effects.	Creatinine	0-10	CRCL	Homo sapiens	22-26
25273515-13	2015	Creatinine clearance (CrCl) was found to have a negative correlation with PRx (Pearson correlation--0.82), with statistically significant crude (p &lt; 0.001) and adjusted (p = 0.001) effects.	Creatinine	0-10	periaxin	Homo sapiens	74-77
26082361-1	2015	OBJECTIVE: To explore the association between urinary microalbumin-to-creatinine ratio (ACR) and brachial-ankle pulse wave velocity (baPWV) in hypertensive patients.	Creatinine	70-80	acrosin	Homo sapiens	88-91
26631737-3	2016	Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 x 10(-10)).	Creatinine	86-96	cubilin	Rattus norvegicus	49-56
26699224-4	2016	RESULTS: Urine cystatin C:creatinine ratio was significantly lower in cats with azotaemic chronic kidney disease than that in healthy cats [3 7 (1 4, 4 3)x10(-6) versus 13 9 (6 3, 24 7)x10(-6) ; P=0 011].	Creatinine	26-36	cystatin-C	Felis catus	15-25
26699224-7	2016	CLINICAL SIGNIFICANCE: Urine cystatin C:creatinine ratio and urine specific gravity were significantly lower in cats with azotaemic chronic kidney disease than that in healthy cats; however, neither biomarker was an adequate sole screening test for azotaemic chronic kidney disease.	Creatinine	40-50	cystatin-C	Felis catus	29-39
26578639-10	2016	OPN levels correlated with T1DM, higher blood pressure, BMI, creatinine, gamma-GT, ALP and lower HDL; the association between high OPN levels and T1DM was independent from all confounders.	Creatinine	61-71	secreted phosphoprotein 1	Homo sapiens	0-3
26422501-5	2016	Results indicate that MR expressed in SMC, but not in endothelium, contributes to the increase of plasma urea and creatinine, the appearance of isometric tubular vacuolization, and overexpression of a kidney injury biomarker (neutrophil gelatinase--associated lipocalin) after CsA treatment.	Creatinine	114-124	nuclear receptor subfamily 3, group C, member 2	Mus musculus	22-24
25527093-9	2015	The addition of metformin or cimetidine significantly reduced the creatinine transepithelial flux, indicating active creatinine uptake in ciPTECs, most likely mediated by the organic cation transporter, OCT2 (SLC22A2).	Creatinine	66-76	solute carrier family 22 member 2	Homo sapiens	203-207
25527093-9	2015	The addition of metformin or cimetidine significantly reduced the creatinine transepithelial flux, indicating active creatinine uptake in ciPTECs, most likely mediated by the organic cation transporter, OCT2 (SLC22A2).	Creatinine	66-76	solute carrier family 22 member 2	Homo sapiens	209-216
25527093-9	2015	The addition of metformin or cimetidine significantly reduced the creatinine transepithelial flux, indicating active creatinine uptake in ciPTECs, most likely mediated by the organic cation transporter, OCT2 (SLC22A2).	Creatinine	117-127	solute carrier family 22 member 2	Homo sapiens	203-207
25527093-9	2015	The addition of metformin or cimetidine significantly reduced the creatinine transepithelial flux, indicating active creatinine uptake in ciPTECs, most likely mediated by the organic cation transporter, OCT2 (SLC22A2).	Creatinine	117-127	solute carrier family 22 member 2	Homo sapiens	209-216
25677700-0	2015	Association of serum resistin with cystatin C and urinary albumin-to-creatinine ratio in elderly Chinese men with essential hypertension.	Creatinine	69-79	resistin	Homo sapiens	21-29
25733917-5	2015	Dolutegravir inhibits the organic cation transporter 2, resulting in decreased creatinine clearance with no apparent decrease in renal function.	Creatinine	79-89	solute carrier family 22 member 2	Homo sapiens	26-54
24819279-4	2015	Mice with renal I/R injury showed a significant increase in blood urea nitrogen and creatinine levels, and these effects were decreased by EPC transplantation.	Creatinine	84-94	transcription factor 21	Mus musculus	139-142
26752184-11	2016	To exclude the effect of sex difference, partial correlations analysis showed that FABP4 was positively correlated with diastolic blood pressure (P&lt;0.05) and body fat percentage (P&lt;0.05) negatively correlated with skeletal muscle mass (P&lt;0.05) and irisin (P&lt;0.05), while irisin was positively correlated with HbA1c (P&lt;0.05) and negatively correlated with creatinine (P&lt;0.05).	Creatinine	370-380	fatty acid binding protein 4	Homo sapiens	83-88
25814621-6	2016	Simple regression analysis showed that the serum irisin concentrations in type 2 diabetes mellitus patients were negatively correlated with age, fasting plasma glucose, homeostasis model assessment of insulin resistance, blood urea nitrogen, creatinine, and positively correlated with creatinine clearance and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers treatment.	Creatinine	242-252	fibronectin type III domain containing 5	Homo sapiens	49-55
25814621-6	2016	Simple regression analysis showed that the serum irisin concentrations in type 2 diabetes mellitus patients were negatively correlated with age, fasting plasma glucose, homeostasis model assessment of insulin resistance, blood urea nitrogen, creatinine, and positively correlated with creatinine clearance and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers treatment.	Creatinine	285-295	fibronectin type III domain containing 5	Homo sapiens	49-55
26683926-7	2015	After adjusting for possible confounders, serum GGT levels were associated with an increased risk of MetS, high waist circumference, high triglyceride level, fasting plasma glucose, DM, and the urinary albumin-to-creatinine ratio (P = 0.001).	Creatinine	213-223	gamma-glutamyltransferase light chain family member 3	Homo sapiens	48-51
26248154-11	2015	CONCLUSIONS: Serum beta2-microglobulin, with values superior to creatinine-based parameters and similar with cystatin C, was a useful biomarker for the prediction of CIN at pre-CCTA and early post-CCTA.	Creatinine	64-74	beta-2-microglobulin	Homo sapiens	19-38
26224498-5	2015	RESULTS: In group A, results obtained in trainings I, II and III showed a statistically significant increase in beta-2M/Cr, NAG/Cr, TP/Cr, ALB/Cr indices in AT compared with the baseline BT values.	Creatinine	120-122	beta-2-microglobulin	Homo sapiens	112-119
26146641-7	2015	CLCF-1 increased urine albumin/creatinine ratio in mice and increased B-cell expression of IgG in mouse spleen.	Creatinine	31-41	cardiotrophin-like cytokine factor 1	Mus musculus	0-6
26335292-7	2015	Serum MCP-1 levels were similar in all groups, whereas urinary MCP-1 levels of the patients with FSGS (1680 pg/mg creatinine) were significantly higher than that of patients with SSNS (365 pg/mg creatinine, p &lt; 0.05) and healthy controls (348 pg/mg creatinine; p &lt; 0.05).	Creatinine	114-124	C-C motif chemokine ligand 2	Homo sapiens	63-68
26290368-3	2015	Compared with controls, ob/ob and LoxTB MC4R-/- mice exhibit significant albuminuria, increased creatinine clearance, and high renal triglyceride content.	Creatinine	96-106	melanocortin 4 receptor	Mus musculus	40-44
24854277-3	2014	After IRI, mice with PTC-specific deletion of p53 (p53 knockout [KO]) had diminished whole-kidney expression levels of p53 and its target genes, improved renal function, which was shown by decreased plasma levels of creatinine and BUN, and attenuated renal histologic damage, oxidative stress, and infiltration of neutrophils and macrophages compared with wild-type mice.	Creatinine	216-226	transformation related protein 53, pseudogene	Mus musculus	46-49
24854277-3	2014	After IRI, mice with PTC-specific deletion of p53 (p53 knockout [KO]) had diminished whole-kidney expression levels of p53 and its target genes, improved renal function, which was shown by decreased plasma levels of creatinine and BUN, and attenuated renal histologic damage, oxidative stress, and infiltration of neutrophils and macrophages compared with wild-type mice.	Creatinine	216-226	transformation related protein 53, pseudogene	Mus musculus	51-54
24854277-3	2014	After IRI, mice with PTC-specific deletion of p53 (p53 knockout [KO]) had diminished whole-kidney expression levels of p53 and its target genes, improved renal function, which was shown by decreased plasma levels of creatinine and BUN, and attenuated renal histologic damage, oxidative stress, and infiltration of neutrophils and macrophages compared with wild-type mice.	Creatinine	216-226	transformation related protein 53, pseudogene	Mus musculus	51-54
24684351-2	2014	Four of the five commercially available DPP-4 inhibitors are subject to significant renal clearance, and pharmacokinetic studies in people with renal impairment have led to lower recommended doses based on creatinine clearance in order to prevent drug accumulation.	Creatinine	206-216	dipeptidyl peptidase 4	Homo sapiens	40-45
25092426-5	2014	Following treatment with cisplatin, the protein expression of GPR40 in the kidneys was decreased in association with an increase in serum creatinine levels and the Bax/Bcl-2 expression ratio.	Creatinine	138-148	free fatty acid receptor 1	Homo sapiens	62-67
24880552-1	2014	Anthocyanidin reductase (ANR) is an NADPH-/NADH-dependent enzyme that transfers two hydrides to anthocyanidins to produce three types of isomeric flavan-3-ols.	Creatinine	84-92	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	25-28
25644107-5	2015	EC-SOD null mice were sensitized to ADR injury, as evidenced by increases in albuminuria, serum creatinine, histologic damage, and oxidative stress.	Creatinine	96-106	superoxide dismutase 3, extracellular	Mus musculus	0-6
25064768-8	2014	Renalase level inversely correlated with serum creatinine (r = -0.36) and arterial blood pressure in the whole population, and with central systolic (r = -0.29) and diastolic pressure (r = -0.35) in study group.	Creatinine	47-57	renalase, FAD dependent amine oxidase	Homo sapiens	0-8
25064768-9	2014	Multivariate regression revealed that serum creatinine and pulse pressure were independent predictors of renalase.	Creatinine	44-54	renalase, FAD dependent amine oxidase	Homo sapiens	105-113
24331939-8	2014	RESULTS: 2-APB significantly reduced serum malondialdehyde, tumor necrosis factor alpha, interleukin 6, aspartate aminotransferase, alanine aminotransferase, and creatinine levels in the I/R injury group.	Creatinine	162-172	arginyl aminopeptidase	Rattus norvegicus	11-14
26435827-12	2015	The study revealed significant positive correlation of hemostatic factors (TM, vWf, PAI-1 &amp; t-PA) with creatinine, urea, hsCRP &amp; CIMT.	Creatinine	107-117	thrombomodulin	Homo sapiens	75-77
26435827-12	2015	The study revealed significant positive correlation of hemostatic factors (TM, vWf, PAI-1 &amp; t-PA) with creatinine, urea, hsCRP &amp; CIMT.	Creatinine	107-117	serpin family E member 1	Homo sapiens	84-89
26147386-7	2015	RESULTS: hs-TnT levels (6.4 ng/l, inter-quartile range 5.0-8.6) were significantly associated with age (r = 0.417, P &lt; 0.001), plasma creatinine levels (r = 0.257, P = 0.027), high-sensitivity C-reactive protein levels (r = 0.281, P = 0.015) and aortic PWV (r = 0.435, P &lt; 0.001).	Creatinine	137-147	troponin T1, slow skeletal type	Homo sapiens	12-15
24621206-7	2014	Lactose was detected at V1 and increased to 0.1 mM/mM creatinine at V2.	Creatinine	54-64	nibrin	Homo sapiens	65-70
24667016-4	2014	We sought to investigate in young patients with type1 diabetes whether pi-Glutathione S-transferase to creatinine (pi-GST:crea) and Tamm-Horsfall protein to creatinine (THP:crea) ratios, markers of distal tubular renal function, relate to subclinical markers of arterial disease, which appear to onset early and develop rapidly in type1 diabetes.	Creatinine	103-113	glutathione S-transferase kappa 1	Homo sapiens	74-99
24729885-5	2014	Carriers of FVL mutation had a significantly lower urine albumin excretion (P = 0.03) and tended to have lower plasma creatinine concentrations (P = 0.07).	Creatinine	118-128	coagulation factor V	Homo sapiens	12-15
24132517-1	2014	The preproghrelin (GHRL) Leu72Met polymorphism (rs 696217) is associated with obesity, reduced glucose-induced insulin secretion in healthy or diabetic subjects, and reduced serum creatinine (Scr) levels in type 2 diabetes.	Creatinine	180-190	ghrelin and obestatin prepropeptide	Homo sapiens	4-17
24132517-1	2014	The preproghrelin (GHRL) Leu72Met polymorphism (rs 696217) is associated with obesity, reduced glucose-induced insulin secretion in healthy or diabetic subjects, and reduced serum creatinine (Scr) levels in type 2 diabetes.	Creatinine	180-190	ghrelin and obestatin prepropeptide	Homo sapiens	19-23
24465439-8	2014	beta-catenin was significantly greater in LN patients without renal interstitial fibrosis compared with those with renal interstitial fibrosis (p&lt;0.01) at the mRNA expression level; the increase in beta-catenin mRNA positively correlated with the creatinine clearance rate (Ccr) and negatively correlated with chronicity indices of renal tissue injury.	Creatinine	250-260	catenin beta 1	Homo sapiens	0-12
24465439-8	2014	beta-catenin was significantly greater in LN patients without renal interstitial fibrosis compared with those with renal interstitial fibrosis (p&lt;0.01) at the mRNA expression level; the increase in beta-catenin mRNA positively correlated with the creatinine clearance rate (Ccr) and negatively correlated with chronicity indices of renal tissue injury.	Creatinine	250-260	catenin beta 1	Homo sapiens	201-213
24409409-9	2014	Treatment with EPO or MEL decreased creatinine, MDA levels, and increased TAC level.	Creatinine	36-46	erythropoietin	Rattus norvegicus	15-18
24507039-9	2014	RESULTS: The median urine periostin in CAN patients was significantly higher than in transplant and healthy controls (1.74 vs 0.00 vs 0.14 ng/mg creatinine, respectively; P &lt; .001).	Creatinine	145-155	periostin	Homo sapiens	26-35
24507039-10	2014	Urine periostin enzyme-linked immunosorbent assay at a cutoff value of 0.152 ng/mg creatinine demonstrated the sensitivity, specificity, and accuracy for distinguishing CAN patients from transplant patients with normal renal function (91.7%, 77.8%, and 85.7%, respectively).	Creatinine	83-93	periostin	Homo sapiens	6-15
24507039-11	2014	In addition, urine periostin levels correlated directly with urine protein creatinine ratio (R = 0.566, P &lt; .001) and serum creatinine (R = 0.522; P &lt; .001), whereas inverse significant correlations were evidenced with estimated glomerular filtration rate (R = -0.431; P &lt; .001).	Creatinine	75-85	periostin	Homo sapiens	19-28
24507039-11	2014	In addition, urine periostin levels correlated directly with urine protein creatinine ratio (R = 0.566, P &lt; .001) and serum creatinine (R = 0.522; P &lt; .001), whereas inverse significant correlations were evidenced with estimated glomerular filtration rate (R = -0.431; P &lt; .001).	Creatinine	127-137	periostin	Homo sapiens	19-28
24305166-1	2013	BACKGROUND: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR.	Creatinine	12-22	CRCL	Homo sapiens	86-90
24305166-1	2013	BACKGROUND: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR.	Creatinine	64-74	CRCL	Homo sapiens	86-90
24305166-1	2013	BACKGROUND: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR.	Creatinine	184-194	CRCL	Homo sapiens	86-90
24305166-6	2013	Our outcome was CrCl/iGFR ratio, a measure of creatinine secretion.	Creatinine	46-56	CRCL	Homo sapiens	16-20
24082055-9	2013	In addition, higher endostatin was associated with higher left ventricular mass, worsened endothelial function, and higher urinary albumin/creatinine ratio (P&lt;0.03 for all) in participants with prevalent hypertension.	Creatinine	139-149	collagen type XVIII alpha 1 chain	Homo sapiens	20-30
24266750-11	2013	We then estimated glomerular filtration rate by using the Creatinine-Cystatin C Equation.	Creatinine	58-68	cystatin C	Rattus norvegicus	69-79
24242684-7	2013	In a multiple linear model, Apo CIII was the best predictor of FII:c variability, after adjustment for age, gender, plasma lipids, CRP, creatinine, diagnosis, and carriership of 20210A allele.	Creatinine	136-146	apolipoprotein C3	Homo sapiens	28-36
24223846-4	2013	We found that Smad4(co/co;Lck-cre) mice exhibited massive glomerular IgA deposition, increased albumin creatinine ratio, aberrant glycosylated IgA, IgA complexed with IgG1 and IgG2a, and polymeric IgA, all known features of IgAN in humans.	Creatinine	103-113	SMAD family member 4	Mus musculus	14-19
23922054-6	2013	Statistically significant covariates included creatinine clearance (CrCL) on clearance, weight and gender on V1 , and weight on peripheral compartment volume (V2 ), but the clinical relevance of these covariates needs to be further evaluated.	Creatinine	46-56	CRCL	Homo sapiens	68-72
26421213-7	2015	Results: The median (interquartile range) urine levels of CC16 (ng/mg of creatinine) at the time of an infant LRTI were 11.1 (7.7-20.1) for infants with subsequent childhood wheeze and 13.4 (8.3-61.1) for those without (p = 0.11).	Creatinine	73-83	secretoglobin family 1A member 1	Homo sapiens	58-62
24218134-5	2013	We assessed in CKD subjects the correlation of hepcidin-25 with creatinine, estimated glomerular filtration rate (eGFR), hemoglobin, blood urea nitrogen, serum iron, transferrin, and ferritin.	Creatinine	64-74	hepcidin antimicrobial peptide	Homo sapiens	47-55
24218134-7	2013	Hepcidin-25 concentrations were directly correlated with creatinine (R = 0.28, P = 0.004) and inversely correlated with eGFR (R = -0.32, P = 0.001).	Creatinine	57-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
24218134-9	2013	CONCLUSION: The direct correlation of hepcidin-25 with creatinine and its inverse correlation with eGFR suggest that hepcidin-25 levels increase as renal function deteriorates, possibly due to decreased hepcidin-25 renal clearance.	Creatinine	55-65	hepcidin antimicrobial peptide	Homo sapiens	38-46
23787995-12	2013	In fact, 24 h after treatment, kidney function began to diminish in gclm(-/-) mice as evident from increased serum creatinine and urea.	Creatinine	115-125	glutamate-cysteine ligase, modifier subunit	Mus musculus	68-72
23729629-1	2013	BACKGROUND: There is debate as to whether using the urinary albumin- or protein-to-creatinine ratio (ACR or PCR) should be the primary test for proteinuria.	Creatinine	83-93	acrosin	Homo sapiens	101-104
23894776-8	2013	The activity of urinary HEXA and HEX B has been calculated per 1 mg of creatinine.	Creatinine	71-81	hexosaminidase subunit alpha	Homo sapiens	24-28
23481506-6	2013	The VWF-pp/ADAMTS13 ratio significantly correlated with Acute Physiology and Chronic Health Evaluation II score on days 1 and 5; Sepsis-related Organ Failure Assessment score on days 1, 3, and 5; maximum Sepsis-related Organ Failure Assessment score and tumor necrosis factor alpha level on days 1, 3, 5, and 7; and creatinine level on days 1, 5, and 7.	Creatinine	316-326	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	11-19
26066465-5	2015	The mean of the serum creatinine levels were significantly higher in patients with variant GG (p=0.006) of rs9624472 in ADORA2A gene compared to AA and AG genotypes in complicated Pf malaria cases, with the G allele also showing increased risk for malaria (OR=1.3(1.1-1.6); p=0.017).	Creatinine	22-32	adenosine A2a receptor	Homo sapiens	120-127
23360846-7	2013	Urinary kidney injury molecule-1 levels were significantly higher at 24 hours in the CP group than in the Control group [48.26 (13.13) vs 8.21 (3.31) pg/mg creatinine; P &lt; 0.05] and remained elevated through day 10.	Creatinine	156-166	hepatitis A virus cellular receptor 1	Rattus norvegicus	8-32
23375099-9	2013	In multivariate correlation analysis in all critically ill patients, the serum A-FABP concentrations were independently related to serum creatinine, fasting plasma glucose, total cholesterol, TNF-alpha, albumin, and the Acute Physiology and Chronic Health Evaluation II scores.	Creatinine	137-147	fatty acid binding protein 4	Homo sapiens	79-85
23577307-8	2013	The correlation between serum Cr and beta2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients.	Creatinine	30-32	beta-2-microglobulin	Homo sapiens	37-44
23577307-10	2013	The correlation between serum Cr and salivary beta2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group.	Creatinine	30-32	beta-2-microglobulin	Homo sapiens	46-53
25823963-4	2015	Creatinine clearance (CRCL), TBW, and BMI were significantly associated with piperacillin pharmacokinetics, and CRCL was significantly associated with tazobactam pharmacokinetics.	Creatinine	0-10	CRCL	Homo sapiens	22-26
25498996-7	2015	Correspondingly, HA enhanced the aberrant expression of nephrin alongside other important regulators of podocyte like podocalyxin, podocin, and CD2AP, and improved renal function by reducing albuminuria/proteinuria, while increasing creatinine clearance.	Creatinine	233-243	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	56-63
26311552-11	2015	(4) The expression of Gas6 mRNA was positively related with body mass index, diastolic blood pressure, systolic blood pressure, free fatty acids and creatinine (P &lt; 0.05), while it was negatively associated with serum albumin (P &lt; 0.05).	Creatinine	149-159	growth arrest specific 6	Homo sapiens	22-26
27140801-5	2015	Body weight and creatinine clearance were important covariates describing the PK of thrombomodulin alfa.	Creatinine	16-26	thrombomodulin	Homo sapiens	84-98
26036531-8	2015	In addition, high levels of IgA anti-Fab antibody correlated with lesser concentration of serum creatinine at 1 month posttransplantation (P = .01).	Creatinine	96-106	FA complementation group B	Homo sapiens	37-40
25294850-7	2015	At baseline, individuals in the highest quartile of DPP4 activity had higher age, body mass index, waist/hip ratio, systolic blood pressure, diastolic blood pressure, fasting insulin, low-density lipoprotein-cholesterol, interleukin-6, high-sensitivity C-reactive protein, urinary albumin-to-creatinine ratio and lower high-density lipoprotein-cholesterol compared with individuals in the lowest quartile.	Creatinine	292-302	dipeptidyl peptidase 4	Homo sapiens	52-56
25904773-9	2015	Dialysate-to-plasma creatinine ratio at 4 h was higher in the PEN group at 12 months and remained so after switching to glucose-based PDF.	Creatinine	20-30	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	62-65
22901921-9	2012	In parallel, urinary TGF-beta(1) and beta(2)-MG (normalized for creatinine) from the postobstructed kidney were significantly higher compared with the contralateral kidney.	Creatinine	64-74	beta-2-microglobulin	Homo sapiens	37-47
25514428-10	2015	The Wnt agonist significantly lowered serum levels of creatinine, aspartate aminotransferase, and lactate dehydrogenase and inhibited the production of interleukin 6 and interleukin 1beta and myeloperoxidase activities.	Creatinine	54-64	Wnt family member 2	Rattus norvegicus	4-7
25385303-8	2015	RESULTS: ANP treatment significantly attenuated cisplatin-induced increases in serum blood urea nitrogen and creatinine, urine albumin/creatinine, and renal expression of IL-1beta, IL-6, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 mRNAs.	Creatinine	109-119	natriuretic peptide type A	Mus musculus	9-12
25385303-8	2015	RESULTS: ANP treatment significantly attenuated cisplatin-induced increases in serum blood urea nitrogen and creatinine, urine albumin/creatinine, and renal expression of IL-1beta, IL-6, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 mRNAs.	Creatinine	135-145	natriuretic peptide type A	Mus musculus	9-12
26229221-6	2015	ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate.	Creatinine	37-47	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	0-8
25892189-8	2015	Decreased estimated PC1/3 activity was significantly associated with type 2 diabetes after adjustment for sex, age, creatinine, triglycerides, HOMA-beta and DI(O).	Creatinine	116-126	proprotein convertase subtilisin/kexin type 1	Homo sapiens	20-25
25363496-8	2015	Compared with young rats, aged rats showed significant increase in creatinine level with cellular senescence in the proximal convoluted tubules confirmed by beta-galactosidase staining.	Creatinine	67-77	galactosidase, beta 1	Rattus norvegicus	157-175
26440635-7	2015	PPMCC analyses showed that blood concentrations of FABP4 were positively associated with: body mass index; areas of fat (total abdominal, visceral, subcutaneous); systolic BP; diastolic BP; total cholesterol; low-density lipoprotein-cholesterol; triacylglycerol; activities of gamma-glutamyl transpeptidase, aspartate aminotransferase and alanine aminotransferase; white blood cell count; and levels of creatinine.	Creatinine	403-413	fatty acid binding protein 4	Homo sapiens	51-56
26480864-7	2015	In the IgG group, there was highly significant relationship of the depth of Hb and albumin decrease and beta(2) M increase to the results of stratification according to ISS, A L and L model (p &lt; 0.0001), increase of LDH in the ISS system and A L, and creatinine according to ISS and L but not the relationship of the stages according to any of the stratification systems to the values of FLC r (ratio of serum free light chains kappa/ lambda of immunoglobulin), thrombocytes and Ca.	Creatinine	254-264	beta-2-microglobulin	Homo sapiens	104-113
26480864-8	2015	In the IgA type, there was a significant relationship of the depth of the decrease of Hb, thrombocytes, albumin and increase of beta(2) M to the results of stratification according to ISS, A L and L and increase of creatinine in the case of ISS, but not of the values of FLC r, Ca and LDH in the case of any of the stratification systems.	Creatinine	215-225	beta-2-microglobulin	Homo sapiens	128-137
25303803-8	2014	RESULTS: Patients with high B2M were older, and had diabetes of longer duration, higher serum creatinine, microalbuminuria, and increased vascular stiffness and C-IMT compared with patients with low B2M.	Creatinine	94-104	beta-2-microglobulin	Homo sapiens	28-31
22991799-8	2012	However, in one patient who had chronic renal failure (creatinine clearance rate: 12 ml x min(-1)), 10 minutes were required for TOF to recover to more than 0.7, and TOF never reached 0.9.	Creatinine	55-65	FEZ family zinc finger 2	Homo sapiens	129-132
22991799-8	2012	However, in one patient who had chronic renal failure (creatinine clearance rate: 12 ml x min(-1)), 10 minutes were required for TOF to recover to more than 0.7, and TOF never reached 0.9.	Creatinine	55-65	FEZ family zinc finger 2	Homo sapiens	166-169
24475394-4	2012	Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blood urea nitrogen and tubal necrosis in gentamicin induced nephrotoxicity in rat.	Creatinine	99-109	erythropoietin	Rattus norvegicus	52-66
24475394-6	2012	They showed that erythropoietin improved significantly serum creatinine and blood urea nitrogen in gentamicin injected rats simultaneously and even after gentamicin nephrotoxicity induction.	Creatinine	61-71	erythropoietin	Rattus norvegicus	17-31
21816412-7	2012	RESULTS: Compared with control groups, the EPO treated group exhibited lower serum urea and creatinine levels, limited tubular necrosis with a lower score of renal histological lesion.	Creatinine	92-102	erythropoietin	Rattus norvegicus	43-46
22113310-6	2012	Persistent IL-10 expression significantly reduced the urinary protein excretion of ZFRs compared with GFP expression (47.1+-11.6 mg per mg creatinine versus 88.8+-30.0 mg per mg creatinine, P&lt;0.01).	Creatinine	139-149	interleukin 10	Rattus norvegicus	11-16
22113310-6	2012	Persistent IL-10 expression significantly reduced the urinary protein excretion of ZFRs compared with GFP expression (47.1+-11.6 mg per mg creatinine versus 88.8+-30.0 mg per mg creatinine, P&lt;0.01).	Creatinine	178-188	interleukin 10	Rattus norvegicus	11-16
25060760-1	2014	BACKGROUND: The objective of this study was to establish age-dependent values for urinary renalase/creatinine (renalase/Cr) ratio in healthy children and adolescents.	Creatinine	99-109	renalase, FAD dependent amine oxidase	Homo sapiens	90-98
22127399-5	2012	There was a significant decrease in both B-type natriuretic peptide (BNP) and urinary albumin creatinine (Cr) excretion ratio (ACR), especially in patients with elevated values.	Creatinine	94-104	acrosin	Homo sapiens	127-130
22127399-5	2012	There was a significant decrease in both B-type natriuretic peptide (BNP) and urinary albumin creatinine (Cr) excretion ratio (ACR), especially in patients with elevated values.	Creatinine	106-108	acrosin	Homo sapiens	127-130
25060760-1	2014	BACKGROUND: The objective of this study was to establish age-dependent values for urinary renalase/creatinine (renalase/Cr) ratio in healthy children and adolescents.	Creatinine	99-109	renalase, FAD dependent amine oxidase	Homo sapiens	111-119
25232508-10	2014	Four weeks after HSC transplantation, Serum creatinine and urea nitrogen decreased 3.5 times and 2.1 times as well as HGF, IGF-1, VEGF and P53 using quantitative real-time PCR increased 4.3 times, 3.2, 2.4 and 4.2 times compared to ARF groups, respectively.	Creatinine	44-54	fucosyltransferase 1 (H blood group)	Homo sapiens	17-20
25182190-5	2014	RESULTS: The expression of both miR-155 and miR-146a was increased more than fivefold in the kidney samples of the DN patients compared with the controls, and the miR-155 expression was closely correlated with the serum creatinine levels (R = 0.95, P = 0.004).	Creatinine	220-230	microRNA 146a	Homo sapiens	44-52
24773611-10	2014	Among AAV patients, correlation analysis showed that the mean optical density of TLR-4 in the glomeruli correlated inversely with the initial serum creatinine, the proportion of total crescents and the proportion of cellular crescents in renal specimens (r = -0 419, P = 0 041; r = -0 506, P = 0 012; r = -0 505, P = 0 012, respectively).	Creatinine	148-158	toll like receptor 4	Homo sapiens	81-86
22282588-6	2012	Compared with wild-type sFlt-1 mice, eNOS-deficient sFlt-1 mice also showed markedly higher urinary albumin excretion (467+-74 versus 174+-23 mug/d), lower creatinine clearance (126+-29 versus 452+-63 mul/min), and more severe endotheliosis.	Creatinine	156-166	nitric oxide synthase 3, endothelial cell	Mus musculus	37-41
22781716-8	2012	The ratio of Notch1 on the membrane of CD38(+)CD138(+) plasma cells of MM patients who had renal dysfunction was correlated to their abnormal serum creatinine levels.	Creatinine	148-158	CD38 molecule	Homo sapiens	39-43
21933002-12	2012	Multivariate analysis revealed resistin and creatinine to be independent predictors of CIMT among adiponectin, leptin, resistin, WHR, glycosylated hemoglobin (HbA1c), and creatinine.	Creatinine	44-54	CIMT	Homo sapiens	87-91
21804084-6	2012	However, urine hepcidin concentration and urinary hepcidin:creatinine ratio were significantly lower at 24 h in patients with RIFLE-Risk, Injury or Failure compared to those without AKI (P = 0.0009 and P &lt; 0.0001, respectively).	Creatinine	59-69	hepcidin antimicrobial peptide	Homo sapiens	50-58
22740902-1	2012	The present study was carried out to evaluate whether measured-creatinine clearance (measured-CrCl) and Cockcroft and Gault-CrCl (CG-CrCl) are capable of appropriately detecting a decline in renal function in lung cancer patients, including elderly patients, and to clarify a CrCl level with which to discriminate between patients with or without renal impairment.	Creatinine	63-73	CRCL	Homo sapiens	94-98
24918534-11	2014	CONCLUSIONS: The results of the present study suggest that diabetes mellitus and inflammation should be associated with lower omentin levels in CKD population; however, this reduction resolves due to the failure of degradation and excretion of omentin when creatinine clearance falls below 30 ml/min (stage 4 CKD).	Creatinine	257-267	intelectin 1	Homo sapiens	244-251
24578103-2	2014	The purpose of this study was to evaluate the utility of a newly introduced semiquantitative urine dipstick, URiSCAN Super cassette ACR (URiSuper-ACR [where ACR is albumin/creatinine ratio]; YD Diagnostics Corp., Korea), as a screening tool for microalbuminuria.	Creatinine	172-182	acrosin	Homo sapiens	132-135
24578103-2	2014	The purpose of this study was to evaluate the utility of a newly introduced semiquantitative urine dipstick, URiSCAN Super cassette ACR (URiSuper-ACR [where ACR is albumin/creatinine ratio]; YD Diagnostics Corp., Korea), as a screening tool for microalbuminuria.	Creatinine	172-182	acrosin	Homo sapiens	146-149
24578103-2	2014	The purpose of this study was to evaluate the utility of a newly introduced semiquantitative urine dipstick, URiSCAN Super cassette ACR (URiSuper-ACR [where ACR is albumin/creatinine ratio]; YD Diagnostics Corp., Korea), as a screening tool for microalbuminuria.	Creatinine	172-182	acrosin	Homo sapiens	146-149
24854597-8	2014	Serum soluble TM was found to be correlated with eGFR (r = -0.766; p &lt; 0.001) and serum creatinine (r = 0.778, p &lt; 0.001).	Creatinine	91-101	thrombomodulin	Homo sapiens	14-16
22105734-3	2012	Reference limits were calculated using the statistical software R. The influence of donor characteristics such as age, sex, body mass index, smoking habits, and creatinine on HE4 levels was investigated using a multivariate model.	Creatinine	161-171	WAP four-disulfide core domain 2	Homo sapiens	175-178
24682935-1	2014	Metallacyclic complex [(Me2N)3Ta(eta(2)-CH2SiMe2NSiMe3)] (3) undergoes C-H activation in its reaction with H3SiPh to afford a Ta/mu-alkylidene/hydride complex, [(Me2N)2{(Me3Si)2N}Ta(mu-H)2(mu-C-eta(2)-CHSiMe2NSiMe3)Ta(NMe2)2] (4).	Creatinine	143-150	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	218-222
22439155-11	2012	In individuals with hyperlipidemia and impaired estimated glomerular filtration rate (eGFR) or creatinine clearance, HMG CoA-reductase inhibitors (statins) reduced risk of mortality (RR 0.80, 95 percent CI, 0.68 to 0.95), myocardial infarction (MI), and stroke compared with placebo.	Creatinine	95-105	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	117-134
23091554-7	2012	The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 (P = 0.011) positive patients than that in the negative patients.	Creatinine	32-42	major histocompatibility complex, class I, B	Homo sapiens	57-62
23091554-7	2012	The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 (P = 0.011) positive patients than that in the negative patients.	Creatinine	32-42	major histocompatibility complex, class I, B	Homo sapiens	87-92
23091554-7	2012	The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 (P = 0.011) positive patients than that in the negative patients.	Creatinine	32-42	major histocompatibility complex, class I, B	Homo sapiens	87-92
24793984-8	2014	Median (IQR) urine MMP-7 concentrations were 6.0 (3.8, 10.5) and 1.0 (0.4, 2.9) mug/g creatinine, respectively (P &lt; 0.001).	Creatinine	86-96	matrix metallopeptidase 7	Homo sapiens	19-24
24599275-6	2014	In multiple linear regression, previous osteoporotic fracture(s) and PTH were independently negatively associated with irisin [p = 0.04, CI -16.1 to -0.4 and p = 0.002, CI -0.3 to -0.07, respectively], but only the association with PTH remained after controlling for creatinine levels.	Creatinine	267-277	fibronectin type III domain containing 5	Homo sapiens	119-125
24599275-8	2014	CONCLUSIONS: Circulating irisin levels were associated with previous osteoporotic fracture(s); whether this association is independent or is due to confounding by lower muscle mass, potentially reflected by lower creatinine levels, remains to be fully clarified.	Creatinine	213-223	fibronectin type III domain containing 5	Homo sapiens	25-31
24669245-10	2014	Positive correlations were identified between leptin and body temperature, heart rate and creatinine levels.	Creatinine	90-100	leptin	Homo sapiens	46-52
22566742-9	2012	On the other hand, patients with MBL deficiency tend to show better clinical presentation and lower levels of urinary protein and serum creatinine than MBL-sufficient patients.	Creatinine	136-146	mannose binding lectin 2	Homo sapiens	33-36
21710586-4	2012	We hypothesized that this drastic change in fluorescence behaviour was due to the presence of creatinine and urea in serum, which might destabilize the quenched beacon, causing an increase in fluorescence followed by decreasing fluorescence as a function of vitamin D concentrations that may bind and quench increasingly greater fractions of the denatured beacons.	Creatinine	94-104	ubiquitin like 5	Homo sapiens	161-167
21814208-7	2011	Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR).	Creatinine	109-119	intelectin 1	Homo sapiens	12-19
24055694-8	2014	High levels of post-transplant IgA-anti-Fab antibody was more frequent in functioning-graft patients (P = 0.00001), correlated with decreased serum creatinine levels (P = 0.01) and associated with improved graft survival (P = 0.008).	Creatinine	148-158	FA complementation group B	Homo sapiens	40-43
25271859-8	2014	APTR (100 and 250 mg/kg) produced a significant decrease (P &lt; 0.05) in the escalated serum concentrations of creatinine and urea by as much as 48.36% and 41.53%, respectively, compared to control.	Creatinine	112-122	Alu-mediated CDKN1A/p21 transcriptional regulator	Rattus norvegicus	0-4
21077957-1	2011	Changes in liver allocation due to institution of the model for end-stage liver disease/PELD criteria have led to an increase in the number of patients receiving liver transplants who have elevated creatinine.	Creatinine	198-208	BSCL2 lipid droplet biogenesis associated, seipin	Homo sapiens	88-92
21738003-7	2011	RESULTS: The albumin/ creatinine ratio (ACR) and prevalence of nephropathy and retinopathy were significantly higher in diabetic patients with GLO1 -7CC genotype than in patients with -7CT and -7TT genotypes (p=0.02, p=0.02, and p=0.04, respectively).	Creatinine	22-32	glyoxalase I	Homo sapiens	143-147
21972820-5	2011	The covariates creatinine clearance (CRCL), age, sex, heart failure and the ethnic subgroup "South Asian" exhibited statistically significant effects on apparent clearance of dabigatran.	Creatinine	15-25	CRCL	Homo sapiens	37-41
21847101-6	2011	Also, Epo-MSCs led to significantly better kidney function as shown by lower levels of blood urea nitrogen (72 +- 9.5 mg/dl versus 131 +- 9.20 mg/dl) and creatinine (74 +- 17 micromol/l versus 148+-19.4 micromol/l).	Creatinine	154-164	erythropoietin	Mus musculus	6-9
21803561-0	2011	Tri-enzyme functionalized ZnO-NPs/CHIT/c-MWCNT/PANI composite film for amperometric determination of creatinine.	Creatinine	101-111	chitinase 1	Homo sapiens	34-38
21996211-10	2011	Upon multiple regression analysis renalase was predicted by 70% using age (beta value 0.21, P=0.043), time after transplantation (beta value, 0.22; P=.037), serum creatinine (beta value, 0.50; P=.016), and diastolic blood pressure (beta value, 0.33; P=.027).	Creatinine	163-173	renalase, FAD dependent amine oxidase	Homo sapiens	34-42
24004970-7	2014	The changes in ACE and ACE2 in CKD were associated with the plasma creatinine concentration in dogs.	Creatinine	67-77	angiotensin I converting enzyme	Canis lupus familiaris	15-18
25138297-6	2014	We found that an age &gt; 75 years, a Karnofsky performance score &lt; 70, altered mentation, and a creatinine clearance (CrCl) &gt; 90 ml/min were significant (p &lt; 0.05) factors associated with a worse survival, by univariate analysis.	Creatinine	100-110	CRCL	Homo sapiens	122-126
24655968-12	2014	Univariate logistic regression revealed the following variables to be associated with serum leptin level: metabolic syndrome, sex, body weight, waist circumference, body mass index (BMI), hypertension, serum creatinine, fasting blood sugar, HbA1c, serum triglyceride, and uric acid.	Creatinine	208-218	leptin	Homo sapiens	92-98
24655968-13	2014	Multivariate analysis revealed that sex, body weight, BMI, and serum creatinine were associated with serum leptin level.	Creatinine	69-79	leptin	Homo sapiens	107-113
23884729-10	2013	There was a statistically significant negative correlation between membrane thickness and creatinine clearance (CrCl), peritoneal Kt/V (pKt/V) and normalized protein catabolic rate.	Creatinine	90-100	CRCL	Homo sapiens	112-116
23228281-6	2013	RESULTS: In hydronephrotic children, preoperative urine levels were significantly increased for EGF (median 7.4 [1.2-60.2] vs. median 4.0 [1.2-13.8] ng/mg creatinine) and MCP-1 (median 136.9 [47.7-545.5] vs. median 80.1 [28.8-149.9] pg/mg creatinine) compared to those of controls.	Creatinine	155-165	epidermal growth factor	Homo sapiens	96-99
23228281-6	2013	RESULTS: In hydronephrotic children, preoperative urine levels were significantly increased for EGF (median 7.4 [1.2-60.2] vs. median 4.0 [1.2-13.8] ng/mg creatinine) and MCP-1 (median 136.9 [47.7-545.5] vs. median 80.1 [28.8-149.9] pg/mg creatinine) compared to those of controls.	Creatinine	239-249	epidermal growth factor	Homo sapiens	96-99
24120076-6	2013	Median urinary CC16 increased from 120 to 310 rhog mumol creatinine(-1) after dry air hyperpnoea (P = 0.002) and from 90 to 191 rhog mumol creatinine(-1) after mannitol (P = 0.021).	Creatinine	57-67	secretoglobin family 1A member 1	Homo sapiens	15-19
24120076-6	2013	Median urinary CC16 increased from 120 to 310 rhog mumol creatinine(-1) after dry air hyperpnoea (P = 0.002) and from 90 to 191 rhog mumol creatinine(-1) after mannitol (P = 0.021).	Creatinine	139-149	secretoglobin family 1A member 1	Homo sapiens	15-19
24220609-10	2013	Kidney transplant recipients negative for the KIR2DL1 gene displayed higher creatinine levels after 5 years.	Creatinine	76-86	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	46-53
24244710-3	2013	The LRRK2 knockout rat, starting at 2-months of age, displayed abnormal kidney staining patterns and/or morphologic changes that were associated with higher serum phosphorous, creatinine, cholesterol, and sorbitol dehydrogenase, and lower serum sodium and chloride compared to the LRRK2 wild-type rat.	Creatinine	176-186	leucine-rich repeat kinase 2	Rattus norvegicus	4-9
24244710-4	2013	Urinalysis indicated pronounced changes in LRRK2 knockout rats in urine specific gravity, total volume, urine potassium, creatinine, sodium, and chloride that started as early as 1- to 2-months of age.	Creatinine	121-131	leucine-rich repeat kinase 2	Rattus norvegicus	43-48
23611517-6	2013	Serum creatinine at time of diagnosis had significant correlation with proteinuria (p = 0.02), urinary levels of IL-1beta (p = 0.03), IL-2 (p = 0.01) and MCP-1 (p = 0.03).	Creatinine	6-16	C-C motif chemokine ligand 2	Homo sapiens	154-159
23852330-7	2013	The pivotal role of hOCT2 for renal secretion of creatinine and metformin was confirmed in clinical studies.	Creatinine	49-59	solute carrier family 22 member 2	Homo sapiens	20-25
23674363-0	2013	The impact of renal tubular damage, as assessed by urinary beta2-microglobulin-creatinine ratio, on cardiac prognosis in patients with chronic heart failure.	Creatinine	79-89	beta-2-microglobulin	Homo sapiens	59-78
21643742-8	2011	The prototype assay was shown to detect CTx peptide from human urine after creatinine and urea were removed by size-exclusion chromatography to prevent nonspecific denaturing of the aptamer beacon.	Creatinine	75-85	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	40-43
21720262-9	2011	Compared with metoprolol alone (which tended to reduce urine output and creatinine excretion/clearance), Ucn2 + metoprolol increased urine volume, sodium and creatinine excretion and clearance.	Creatinine	72-82	urocortin-2	Ovis aries	105-109
21720262-9	2011	Compared with metoprolol alone (which tended to reduce urine output and creatinine excretion/clearance), Ucn2 + metoprolol increased urine volume, sodium and creatinine excretion and clearance.	Creatinine	158-168	urocortin-2	Ovis aries	105-109
21334759-1	2011	BACKGROUND: Creatinine clearance (CrCl) estimation by Cockcroft-Gault calculation (CG) often replaces measurement of glomerular filtration rate (GFR) by [(51)Cr]-ethylenediaminetetraacetic acid clearance (EDTA).	Creatinine	12-22	CRCL	Homo sapiens	34-38
21334759-9	2011	CONCLUSION: CG estimation of CrCl is accurate and safe in lung cancer patients with potentially nephrotoxic co-morbidity or concomitant medication, but should not be used when values are outside the range 50-120 ml/min, or with abnormally elevated serum creatinine.	Creatinine	254-264	CRCL	Homo sapiens	29-33
21263384-9	2011	Treatment with C-peptide significantly attenuated the rise in creatinine and kidney myeloperoxidase activity when compared with vehicle group.	Creatinine	62-72	insulin 2	Rattus norvegicus	15-24
20943446-8	2011	CONCLUSIONS: In patients with cirrhosis and hyperdynamic circulation, but with normal serum creatinine, urotensin II is higher than in healthy subjects.	Creatinine	92-102	urotensin 2	Homo sapiens	104-116
20721554-5	2011	Urinary hepcidin was elevated in dysmetabolic hyperferritinemia (median; 1,584 g/mg of creatinine vs. 799 ng/mg of creatinine, p = 0.05).	Creatinine	87-97	hepcidin antimicrobial peptide	Homo sapiens	8-16
20721554-5	2011	Urinary hepcidin was elevated in dysmetabolic hyperferritinemia (median; 1,584 g/mg of creatinine vs. 799 ng/mg of creatinine, p = 0.05).	Creatinine	115-125	hepcidin antimicrobial peptide	Homo sapiens	8-16
23674363-4	2013	METHODS AND RESULTS: Urinary beta2-microglobulin-creatinine ratio was measured in 315 patients with CHF.	Creatinine	49-59	beta-2-microglobulin	Homo sapiens	29-48
23674363-5	2013	Renal tubular damage was defined as a urinary beta2-microglobulin-creatinine ratio &gt;= 300 mug/g, as previously reported.	Creatinine	66-76	beta-2-microglobulin	Homo sapiens	46-65
23674363-8	2013	Log10 urinary beta2-microglobulin-creatinine ratio was increased with worsening New York Heart Association functional class.	Creatinine	34-44	beta-2-microglobulin	Homo sapiens	14-33
23678231-7	2013	Urinary creatinine standardized uPAR (in pg mL mug-1 creatinine) changed significantly between groups, decreasing by about half following seaweed supplementation (placebo 1, 1.5 (95 % CI, 0.9-2.1) and seaweed, 0.9 (95 % CI, 0.6-1.1) while placebo 2 returned to pre-seaweed concentration (1.7 (95 % CI, 1.2-2.2); p = 0.01, ANOVA).	Creatinine	53-63	plasminogen activator, urokinase receptor	Homo sapiens	32-36
20972945-5	2011	Furthermore, serum creatinine independently predicted FIAF/Angptl4 concentrations in multiple regression analyses in control subjects (p&lt;0.01).	Creatinine	19-29	angiopoietin like 4	Homo sapiens	54-58
20972945-5	2011	Furthermore, serum creatinine independently predicted FIAF/Angptl4 concentrations in multiple regression analyses in control subjects (p&lt;0.01).	Creatinine	19-29	angiopoietin like 4	Homo sapiens	59-66
21287408-8	2011	Patients with severe ADAMTS13 deficiency had lower serum creatinine levels at presentation, but severe ADAMTS13 activity deficiency at TTP diagnosis does not appear to have prognostic significance.	Creatinine	57-67	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	21-29
20621933-8	2011	UII concentrations correlated negatively with serum creatinine (P=0.0012) and CKD stage, and positively with creatinine clearance (P=0.013).	Creatinine	52-62	urotensin 2	Homo sapiens	0-3
20621933-8	2011	UII concentrations correlated negatively with serum creatinine (P=0.0012) and CKD stage, and positively with creatinine clearance (P=0.013).	Creatinine	109-119	urotensin 2	Homo sapiens	0-3
21245596-10	2011	Serum OX40L levels correlated with serum creatinine levels but not with SLEDAI.	Creatinine	41-51	TNF superfamily member 4	Homo sapiens	6-11
20490623-6	2010	Also, higher beta2-MG concentrations (&gt;200mug/g creatinine) were found in the population with U-Cd concentrations greater than 2.5mug/L.	Creatinine	51-61	beta-2-microglobulin	Homo sapiens	13-21
21253362-3	2010	We determined the association between albuminuria measured by the urine albumin creatinine ratio (UACR) and carotid intima media thickness (CIMT) in a Korean rural population.	Creatinine	80-90	CIMT	Homo sapiens	140-144
20719840-2	2010	Our present study showed a significant association between low-grade urinary albumin-to-creatinine ratio (ACR) and elevated carotid intima-media thickness (CIMT) in type 2 diabetic patients.	Creatinine	88-98	CIMT	Homo sapiens	156-160
23723977-9	2013	A complex pattern of correlations with urine creatinine, albumin and beta-2-microglobulin was observed indicating the presence of highly specific mechanisms of renal filtration.	Creatinine	45-55	beta-2-microglobulin	Homo sapiens	69-89
23667695-7	2013	The decrease in irisin levels was inversely correlated with the levels of blood urea nitrogen and creatinine.	Creatinine	98-108	fibronectin type III domain containing 5	Homo sapiens	16-22
23619263-6	2013	IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio.	Creatinine	115-125	insulin like growth factor binding protein 3	Homo sapiens	0-7
24364044-11	2013	Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance.	Creatinine	80-90	leptin	Homo sapiens	6-12
23001587-7	2012	Creatinine clearance (CrCL) was the only covariate with a significant effect on the PK of AZD9773.	Creatinine	0-10	CRCL	Homo sapiens	22-26
22726275-6	2012	RESULTS: The IgG3 deficiency patient had significantly longer duration of admission and period of oseltamivir, with a significantly decreased pulse oxygen saturation and increased maximum serum C-reactive protein, creatine kinase and urinary excretion of beta2-microglobulin/creatinine, compared with the controls (P &lt; 0.05).	Creatinine	275-285	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	13-17
23301483-9	2012	CONCLUSION: Acupuncture can reduce significantly the level of DPD/Cr, Ca/Cr, and the serum contents of ALP, BGP, TNF-alpha and ICTP, increase significantly the level of E2 and PICP in PMO model rats and EA with tonification and dispersing blood stasis method is superior significantly to the other routine acupuncture methods.	Creatinine	66-68	dihydropyrimidine dehydrogenase	Rattus norvegicus	62-65
19889873-9	2010	Compared to the ADR+IgG group, ADR+MR1 animals had significantly less histological injury (glomerulosclerosis and tubular atrophy) and functional injury (creatinine clearance).	Creatinine	154-164	major histocompatibility complex, class I-related	Mus musculus	35-38
20085934-12	2010	Multivariate analysis noted correlations between albumin and creatinine to presurgery OPN and use of thoracotomy to postsurgery OPN.	Creatinine	61-71	secreted phosphoprotein 1	Homo sapiens	86-89
19892029-7	2010	Moreover, nitrite treatment enhanced renal dysfunction in the form of increased plasma [creatinine] in eNOS KO mice.	Creatinine	88-98	nitric oxide synthase 3, endothelial cell	Mus musculus	103-107
21377848-3	2012	The urinary levels of cystatin C, GST-alpha, KIM-1, and EGF changed prior to proximal tubule damage and increases in plasma urea nitrogen and creatinine levels, suggesting their usefulness for predicting AKI.	Creatinine	142-152	cystatin C	Rattus norvegicus	22-32
22840426-9	2012	Independent direct associations were observed between PAI-1 and waist circumference, serum triglycerides, insulin, alcohol use and age and inverse with serum creatinine, HDL-cholesterol and adiponectin.	Creatinine	158-168	serpin family E member 1	Homo sapiens	54-59
22045831-10	2012	On analysis of secondary outcomes, it was observed that creatinine levels at hospital discharge were lower in patients receiving NAC plus DFX when compared with placebo.	Creatinine	56-66	synuclein alpha	Homo sapiens	129-132
22045831-11	2012	NAC plus DFX administration was able to decrease plasma markers of oxidative damage and creatinine levels at hospital discharge.	Creatinine	88-98	synuclein alpha	Homo sapiens	0-3
22534631-6	2012	Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r = -0.398; P = 0.015), statin usage (r = -0.393; P = 0.016), and beta-blocker usage (r = -0.365; P = 0.026).	Creatinine	90-100	resistin	Homo sapiens	0-8
22167593-10	2012	Urine periostin enzyme-linked immunosorbent assay at a cutoff of 32.66 pg/mg creatinine demonstrated sensitivity and specificity for distinguishing patients with CKD from healthy people (92.3 and 95.0%, respectively) comparing favorably with urine neutrophil gelatinase-associated lipocalin.	Creatinine	77-87	periostin	Homo sapiens	6-15
22841237-10	2012	The serum creatinine decrease rates of the 9 C1q-positive versus the 15 C1q-negative subjects showed significant difference (P &lt; .05).	Creatinine	10-20	complement C1q A chain	Homo sapiens	45-48
22841237-10	2012	The serum creatinine decrease rates of the 9 C1q-positive versus the 15 C1q-negative subjects showed significant difference (P &lt; .05).	Creatinine	10-20	complement C1q A chain	Homo sapiens	72-75
23067168-3	2012	Data on renal excretion of albumin (albumin/creatinine ratio - ACR) and the prevalence of microalbuminuria in apparently healthy adolescents are scares.	Creatinine	44-54	acrosin	Homo sapiens	63-66
20001492-9	2010	In patients with mild renal impairment (creatinine clearance [CrCL]: 50-80 mL/min), dosage should be adjusted.	Creatinine	40-50	CRCL	Homo sapiens	62-66
20374368-9	2009	Urinary MCP-1 correlated positively with proteinuria, and negatively with creatinine clearance and hemoglobin; thus, urinary MCP-1 correlates with the severity of nephritis.	Creatinine	74-84	C-C motif chemokine ligand 2	Homo sapiens	125-130
19919977-5	2009	Compared with furosemide treatment alone, Ucn2+furosemide produced a further diuresis (P&lt;0.05), natriuresis (P&lt;0.05), and a sustained increase in creatinine excretion (P&lt;0.05) and clearance (P&lt;0.05), without additional potassium elimination.	Creatinine	152-162	urocortin-2	Ovis aries	42-46
19808377-7	2009	Urocortin 1 levels were increased in patients with heart failure and were related to functional class, clinical signs of heart failure, echocardiographic indicators of left ventricular dimensions and function, plasma creatinine, and concurrent circulating levels of plasma natriuretic peptides, adrenomedullin, and endothelin 1.	Creatinine	217-227	urocortin	Homo sapiens	0-9
19950779-8	2009	We observe a significant increase in the activity of HEX, HEX A and HEX B expressed in pKat/mg of creatinine was found in urine of patients bearing tumor of diameter 6.0-7.0 cm in comparison to patients with tumor of diameter 4.0-5.0 cm.	Creatinine	98-108	hexosaminidase subunit alpha	Homo sapiens	58-63
23067168-5	2012	ACR (0.43; 0.29-0.67 mg albumin/mmol creatinine vs 0.35; 0.25-0.51 mg albumin/mmol creatinine, p &lt; 0.001), and the prevalence of microalbuminuria (3.6 % vs 1.2 %, chi2: p = 0.024) were higher in girls than in boys.	Creatinine	37-47	acrosin	Homo sapiens	0-3
23067168-5	2012	ACR (0.43; 0.29-0.67 mg albumin/mmol creatinine vs 0.35; 0.25-0.51 mg albumin/mmol creatinine, p &lt; 0.001), and the prevalence of microalbuminuria (3.6 % vs 1.2 %, chi2: p = 0.024) were higher in girls than in boys.	Creatinine	83-93	acrosin	Homo sapiens	0-3
22338083-0	2012	A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.	Creatinine	55-65	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	41-45
19002550-2	2009	Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula.	Creatinine	37-47	CRCL	Homo sapiens	59-63
19578006-4	2009	In mice, the absence of Rab3A and blockade of NMDAR both associated with an increased urinary albumin/creatinine ratio.	Creatinine	102-112	RAB3A, member RAS oncogene family	Mus musculus	24-29
19578006-4	2009	In mice, the absence of Rab3A and blockade of NMDAR both associated with an increased urinary albumin/creatinine ratio.	Creatinine	102-112	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	46-51
19143943-8	2009	EGF urinary excretion was a strong predictor factor of disease outcome, significantly correlated with creatinine clearance at time of diagnosis (r = 0.5, P = 0.005), and at the end of follow up (r = 0.6, P = 0.001).	Creatinine	102-112	epidermal growth factor	Homo sapiens	0-3
18853098-5	2009	Serum SSAO activity was higher in type 2 diabetic patients than in control group and serum SSAO in type 2 diabetic correlated with age, serum creatinine and total cholesterol.	Creatinine	142-152	amine oxidase copper containing 2	Homo sapiens	6-10
18853098-5	2009	Serum SSAO activity was higher in type 2 diabetic patients than in control group and serum SSAO in type 2 diabetic correlated with age, serum creatinine and total cholesterol.	Creatinine	142-152	amine oxidase copper containing 2	Homo sapiens	91-95
22338083-3	2012	Here, we demonstrate specific uptake of creatinine into mouse mOat1- and mOat3-microinjected Xenopus laevis oocytes at a concentration of 10 muM (i.e., similar to physiological plasma levels), which was inhibited by both probenecid and cimetidine, prototypical competitive inhibitors of organic anion and cation transporters, respectively.	Creatinine	40-50	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	73-78
22338083-8	2012	Plasma creatinine concentrations of Oat3-/- were elevated in clearance studies under anesthesia but not following brief isoflurane anesthesia, indicating that the former condition enhanced the quantitative contribution of OAT3 for renal creatinine secretion.	Creatinine	7-17	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	36-40
22338083-8	2012	Plasma creatinine concentrations of Oat3-/- were elevated in clearance studies under anesthesia but not following brief isoflurane anesthesia, indicating that the former condition enhanced the quantitative contribution of OAT3 for renal creatinine secretion.	Creatinine	237-247	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	36-40
22338083-8	2012	Plasma creatinine concentrations of Oat3-/- were elevated in clearance studies under anesthesia but not following brief isoflurane anesthesia, indicating that the former condition enhanced the quantitative contribution of OAT3 for renal creatinine secretion.	Creatinine	237-247	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	222-226
22338083-9	2012	The results are consistent with a contribution of OAT3 and possibly OAT1 to renal creatinine secretion in mice.	Creatinine	82-92	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	50-54
22425148-8	2012	Dichloromethylamine (CH(3)NCl(2)) formation from creatinine was promoted by UV exposure, when free chlorine was present in solution; however, when free chlorine was depleted, CH(3)NCl(2) photodecay was observed.	Creatinine	49-59	calpain 8	Homo sapiens	26-32
22425148-8	2012	Dichloromethylamine (CH(3)NCl(2)) formation from creatinine was promoted by UV exposure, when free chlorine was present in solution; however, when free chlorine was depleted, CH(3)NCl(2) photodecay was observed.	Creatinine	49-59	calpain 8	Homo sapiens	180-186
22126194-3	2012	METHODS: Erythropoietin was injected in the peritoneal space of ICR mice after ischemia/reperfusion injury and its effect was assessed by measuring blood urea nitrogen and creatinine, and by histological analysis.	Creatinine	172-182	erythropoietin	Mus musculus	9-23
22126194-6	2012	RESULTS: Erythropoietin administration significantly inhibited the increase in blood urea nitrogen and creatinine after ischemia/reperfusion injury compared with control mice.	Creatinine	103-113	erythropoietin	Mus musculus	9-23
22223530-0	2012	Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.	Creatinine	30-40	solute carrier family 22 member 2	Homo sapiens	71-75
22223530-6	2012	In a genetic association analysis (n = 590), several polymorphisms around the OCT2/SLC22A2 gene locus, including rs2504954 (P = 0.000873), were significantly associated with age-adjusted creatinine levels.	Creatinine	187-197	solute carrier family 22 member 2	Homo sapiens	78-82
22223530-6	2012	In a genetic association analysis (n = 590), several polymorphisms around the OCT2/SLC22A2 gene locus, including rs2504954 (P = 0.000873), were significantly associated with age-adjusted creatinine levels.	Creatinine	187-197	solute carrier family 22 member 2	Homo sapiens	83-90
22223530-7	2012	Furthermore, in cancer patients (n = 68), the OCT2 substrate cisplatin caused an acute elevation of serum creatinine (P = 0.0083), consistent with inhibition of an elimination pathway.	Creatinine	106-116	solute carrier family 22 member 2	Homo sapiens	46-50
22223530-8	2012	CONCLUSIONS: Collectively, this study shows that OCT2 plays a decisive role in the renal secretion of creatinine.	Creatinine	102-112	solute carrier family 22 member 2	Homo sapiens	49-53
22223530-9	2012	This process can be inhibited by OCT2 substrates, which impair the usefulness of creatinine as a marker of renal function.	Creatinine	81-91	solute carrier family 22 member 2	Homo sapiens	33-37
21804084-7	2012	Receiver operator characteristic analysis showed that lower 24-h urine hepcidin concentration and urinary hepcidin:creatinine ratio were sensitive and specific predictors of AKI.	Creatinine	115-125	hepcidin antimicrobial peptide	Homo sapiens	106-114
21804084-8	2012	The urinary hepcidin:creatinine ratio had an area under the curve for the diagnosis of RIFLE &gt;= risk at 24 h of 0.77 and of 0.84 for RIFLE &gt;= injury.	Creatinine	21-31	hepcidin antimicrobial peptide	Homo sapiens	12-20
21804084-11	2012	CONCLUSIONS: Urinary hepcidin and hepcidin:creatinine ratio are biomarkers of AKI after CPB, with an inverse association between its increase at 24 h and risk of AKI in the first five post-operative days.	Creatinine	43-53	hepcidin antimicrobial peptide	Homo sapiens	34-42
22897373-0	2012	Serum leptin level has a positive correlation with BMI and creatinine clearance in CAPD patients.	Creatinine	59-69	leptin	Homo sapiens	6-12
21834728-9	2012	Treatments with EPO restored creatinine and BUN levels and inhibited Cisp-induced DNA damage in the kidney.	Creatinine	29-39	erythropoietin	Rattus norvegicus	16-19
22106404-3	2012	After 4 weeks of Nx, wild-type mice with renal mass reduction exhibited increased blood urea nitrogen, plasma creatinine and phosphorus concentrations, and defective urine concentrating capability, all of which were significantly attenuated by mPGES-1 deletion.	Creatinine	110-120	prostaglandin E synthase	Mus musculus	244-251
21439764-1	2011	PURPOSE: We hypothesized that RIFLE based on creatinine clearance (CrCl) is superior to that based on serum creatinine (sCr) or Cockroft-Gault (C-G) because it is an earlier marker of kidney dysfunction.	Creatinine	45-55	CRCL	Homo sapiens	67-71
21922214-5	2011	Urinary mRNA expression of T-bet correlated with the urinary protein/creatinine ratio (r = 0.608, p = 0.013), and correlated inversely with serum level of total protein (r = -0.574, p = 0.020).	Creatinine	69-79	T-box transcription factor 21	Homo sapiens	27-32
22172866-9	2011	Multiple regression analysis showed renalase concentration to be predicted in 75% by serum creatinine (beta value, 0.79; P=.0000000; SE 3.00; F statistics 15.96; P&lt;.0000001).	Creatinine	91-101	renalase, FAD dependent amine oxidase	Homo sapiens	36-44
21833587-8	2011	The postnatal deletion of the Pdgfr-beta gene significantly decreased the urinary albumin/creatinine ratio and mesangial area/glomerular area ratio without affecting the plasma glucose concentration.	Creatinine	90-100	platelet derived growth factor receptor, beta polypeptide	Mus musculus	30-40
20163634-11	2009	Microbial protein (MBP) was estimated based on purine derivatives and creatinine excreted in spot urine samples.	Creatinine	70-80	myelin basic protein	Capra hircus	0-17
20163634-11	2009	Microbial protein (MBP) was estimated based on purine derivatives and creatinine excreted in spot urine samples.	Creatinine	70-80	myelin basic protein	Capra hircus	19-22
19491317-7	2009	Creatinine clearance (CrCl) less than 60 mL/min resulted in higher MPA exposure, total area under the curve (AUC)(0-12), and AUC(6-12), as well as unbound AUC(0-12).	Creatinine	0-10	CRCL	Homo sapiens	22-26
19325138-0	2009	Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate.	Creatinine	76-86	apolipoprotein A2	Homo sapiens	46-53
19486524-11	2009	In septic animals the phosphodiesterase 3 inhibitor, amrinone, preserved the tissue cAMP level, renal structural changes, and attenuated the increased blood urea nitrogen, creatinine, and iNOS expression in the kidney.	Creatinine	172-182	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	22-41
19242319-6	2009	Stratification of G-CSF levels into quartiles revealed a strong association between the highest levels of G-CSF and an increased risk of death and decreased ventilator-free days and organ failure-free days in multivariate analyses controlling for ventilation strategy, Acute Physiology and Chronic Health Evaluation III score, Pao2/Fio2 ratio, creatinine, and platelet count (p &lt; 0.05).	Creatinine	344-354	colony stimulating factor 3	Homo sapiens	18-23
19242319-6	2009	Stratification of G-CSF levels into quartiles revealed a strong association between the highest levels of G-CSF and an increased risk of death and decreased ventilator-free days and organ failure-free days in multivariate analyses controlling for ventilation strategy, Acute Physiology and Chronic Health Evaluation III score, Pao2/Fio2 ratio, creatinine, and platelet count (p &lt; 0.05).	Creatinine	344-354	colony stimulating factor 3	Homo sapiens	106-111
19054333-6	2009	RESULTS: Uroguanylin did not increase urinary excretion of sodium and water in normal rats, but significantly increased urinary sodium excretion during the sodium retention phase in nephrotic rats (untreated vs uroguanylin-treated nephrotic rats in mmol/mmol creatinine; 2.92 +/- 0.65 vs 8.93 +/- 2.53 on day 6, P &lt; 0.05; 3.55 +/- 0.47 vs 10.37 +/- 1.73 on day 7, P &lt; 0.01; 14.88 +/- 2.32 vs 24.47 +/- 2.86 on day 8, P &lt; 0.05).	Creatinine	259-269	guanylate cyclase activator 2B	Rattus norvegicus	9-20
19144150-10	2009	FcgammaRI/CD64 expression was positively associated with serum creatinine and indicators of systemic inflammation.	Creatinine	63-73	Fc gamma receptor Ia	Homo sapiens	0-9
19144150-10	2009	FcgammaRI/CD64 expression was positively associated with serum creatinine and indicators of systemic inflammation.	Creatinine	63-73	Fc gamma receptor Ia	Homo sapiens	10-14
18931100-3	2009	RESULTS: Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P &lt; 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P &lt; 0.05, respectively).	Creatinine	69-79	fatty acid binding protein 4	Homo sapiens	15-21
21848642-8	2011	Additionally, PAI-1(-/-) mice showed elevated levels of proinflammatory cytokines in lungs and plasma, accompanied by enhanced local and systemic coagulation activation (thrombin-antithrombin complexes and D-dimer), increased hepatocellular injury (plasma aspartate aminotransferase and alanine aminotransferase), and renal failure (plasma creatinine and urea).	Creatinine	340-350	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	14-19
18849305-6	2009	In addition, markers of adiposity (body mass index, serum leptin), triglycerides and serum creatinine were independently associated with circulating AFABP (P&lt;0.05).	Creatinine	91-101	fatty acid binding protein 4	Homo sapiens	149-154
21372262-3	2011	Creatinine clearance (CrCl) provides a substitute, provided urine is collected accurately and tubular creatinine handling can be accounted for.	Creatinine	0-10	CRCL	Homo sapiens	22-26
21372262-3	2011	Creatinine clearance (CrCl) provides a substitute, provided urine is collected accurately and tubular creatinine handling can be accounted for.	Creatinine	102-112	CRCL	Homo sapiens	22-26
21372262-15	2011	The impact of BMI on tubular creatinine secretion can be accounted for, when using CrCl for GFR assessment in the normal to high range, by the following formula: GFR = 24-h CrCl - (22.75 + 0.76 x BMI - 0.29 x mean arterial pressure (-6.11 if female).	Creatinine	29-39	CRCL	Homo sapiens	83-87
21372262-15	2011	The impact of BMI on tubular creatinine secretion can be accounted for, when using CrCl for GFR assessment in the normal to high range, by the following formula: GFR = 24-h CrCl - (22.75 + 0.76 x BMI - 0.29 x mean arterial pressure (-6.11 if female).	Creatinine	29-39	CRCL	Homo sapiens	173-177
21761075-5	2011	The SERS spectra were used to generate and validate a PLS model and also to predict the creatinine concentration of an unknown serum sample.	Creatinine	88-98	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
19755764-4	2009	The urinary excretion of albumin in the first void urine was expressed as the creatinine ratio (ACR, mg/gCr).	Creatinine	78-88	acrosin	Homo sapiens	96-99
19690440-6	2009	Serum levels of sTNFR1 and sTNFR2 correlated with serum creatinine, while the surface expression of TNFR1 and TNFR2 on the granulocytes did not.	Creatinine	56-66	TNF receptor superfamily member 1A	Homo sapiens	17-22
21350838-8	2011	ILK expression correlated significantly with 24-h urinary protein excretion, serum creatinine levels, tubulointerstitial mononuclear cells infiltration, smooth muscle cells (SMCs) migration in vascular wall, and interstitial fibrosis.	Creatinine	83-93	integrin-linked kinase	Rattus norvegicus	0-3
21646940-8	2011	We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories.	Creatinine	51-53	beta-2-microglobulin	Homo sapiens	44-48
21646940-8	2011	We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories.	Creatinine	66-68	beta-2-microglobulin	Homo sapiens	44-48
21458841-5	2011	The adjusted odds ratio for an abnormal beta2 microglobulin (B2MG&gt;0.154 mg L(-1)) was significantly higher in subjects with U-As&gt;35 mug g(-1) creatinine as compared with the reference group adjusted for age, sex, living area, cigarette smoking, diabetes, and hypertension.	Creatinine	148-158	beta-2-microglobulin	Homo sapiens	40-59
18528327-3	2008	In 54 patients with less than 20% chronic damage, there was a significant correlation between the urinary albumin to creatinine ratio and MCP-1/CCL2, and MCP-1/CCL2 and macrophages but not between MCP-1/CCL2 and capillary density.	Creatinine	117-127	C-C motif chemokine ligand 2	Homo sapiens	138-143
18528327-3	2008	In 54 patients with less than 20% chronic damage, there was a significant correlation between the urinary albumin to creatinine ratio and MCP-1/CCL2, and MCP-1/CCL2 and macrophages but not between MCP-1/CCL2 and capillary density.	Creatinine	117-127	C-C motif chemokine ligand 2	Homo sapiens	144-148
21536988-6	2011	Chronic urocortin 2 also persistently augmented urinary sodium (day 4: 4-fold increase; P&lt;0.001) and creatinine (1.4-fold; P&lt;0.001) excretion and creatinine clearance (1.5-fold; P&lt;0.01) compared with control.	Creatinine	104-114	urocortin-2	Ovis aries	8-19
21536988-6	2011	Chronic urocortin 2 also persistently augmented urinary sodium (day 4: 4-fold increase; P&lt;0.001) and creatinine (1.4-fold; P&lt;0.001) excretion and creatinine clearance (1.5-fold; P&lt;0.01) compared with control.	Creatinine	152-162	urocortin-2	Ovis aries	8-19
21327479-2	2011	The efficacy of ERT was established based primarily on reduction in urine glycosaminoglycans:creatinine (GAG:Cr) ratio and improvement in a composite score of predicted forced vital capacity (FVC% predicted) and 6-min walk-test distance (6MWT).	Creatinine	93-103	E74 like ETS transcription factor 3	Homo sapiens	16-19
21781485-2	2011	METHODS: PAD, defined as an ankle brachial index (ABI) &lt;= 0.9 in either leg and renal insufficiency, defined as an estimated creatinine clearance (CRCL) &lt; 60 mlxmin(-1)x1.73 m(-1) were evaluated in 5270 Chinese patients at high risk of CV.	Creatinine	128-138	CRCL	Homo sapiens	150-154
18625649-6	2008	A positive correlation was found between TM and serum creatinine (r = 0.617, P &lt; 0.05) in patients with vascular lesions.	Creatinine	54-64	thrombomodulin	Homo sapiens	41-43
21512075-9	2011	CONCLUSION: The incidence of CIN in patients with multiple myeloma with a normal creatinine level is low and correlates with beta(2)-microglobulin levels.	Creatinine	81-91	beta-2-microglobulin	Homo sapiens	125-146
21478207-7	2011	Multivariable regression analyses revealed that both IGF-I and IGFBP-3 concentrations were independently associated with waist circumference, fasting insulin and haemoglobin concentrations in boys (all P &lt; 0.05), systolic blood pressure, serum creatinine, fasting insulin and haemoglobin concentrations in girls (all P &lt; 0.05).	Creatinine	247-257	insulin like growth factor binding protein 3	Homo sapiens	63-70
21273355-8	2011	The incidence of elevation in creatinine values at 6 months after CAS was 8.2% (6/73).	Creatinine	30-40	BCAR1 scaffold protein, Cas family member	Homo sapiens	66-69
19808282-8	2008	Renal effects of AM2 included increased excretion of sodium (P&lt;0.05), cAMP (P&lt;0.01), and creatinine (P&lt;0.05), with augmented creatinine clearance (P&lt;0.05), and a trend for urine output to rise (P=0.068).	Creatinine	95-105	adrenomedullin 2	Homo sapiens	17-20
19808282-8	2008	Renal effects of AM2 included increased excretion of sodium (P&lt;0.05), cAMP (P&lt;0.01), and creatinine (P&lt;0.05), with augmented creatinine clearance (P&lt;0.05), and a trend for urine output to rise (P=0.068).	Creatinine	134-144	adrenomedullin 2	Homo sapiens	17-20
21143502-18	2011	TOB total clearance (CL(TOB) ) was significantly correlated with Cockcroft creatinine clearance (COCK) and height.	Creatinine	75-85	transducer of ERBB2, 1	Homo sapiens	0-3
21143502-18	2011	TOB total clearance (CL(TOB) ) was significantly correlated with Cockcroft creatinine clearance (COCK) and height.	Creatinine	75-85	transducer of ERBB2, 1	Homo sapiens	21-28
24968654-10	2011	Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault formula.	Creatinine	0-10	CRCL	Homo sapiens	22-26
18387391-7	2008	In the CyA group, post-treatment urinary EGF levels were significantly reduced (from 35 +/- 15.8 to 28.3 +/- 17.9 ng/mg creatinine; P &lt;0.034), whereas the urinary IL-6 levels were not affected by CyA or PPS treatment in the whole group.	Creatinine	120-130	epidermal growth factor	Homo sapiens	41-44
18171994-5	2008	GTP cyclohydrolase-1 transgenic (Tg) mice demonstrated a significant increase in baseline urine NO-to-creatinine ratio and a more significant increase in renal iNOS expression and serum NO levels with LPS treatment compared with the wild-type (WT) mice.	Creatinine	102-112	GTP cyclohydrolase 1	Mus musculus	0-20
18308223-4	2008	Creatinine clearance (CrCl) for each patient was determined using the Cockcroft-Gault equation and ideal body weight.	Creatinine	0-10	CRCL	Homo sapiens	22-26
20825465-11	2011	Using the same model, log leptin and log adiponectin presented positive and negative associations, respectively with LTE(4) /creatinine in urine.	Creatinine	125-135	leptin	Homo sapiens	26-32
18955361-8	2011	In conclusion, ACE reduced urine protein and creatinine levels and suppressed the thickening of the kidney glomerular basement membrane, suggesting that ACE protects the kidney from immunological damage resulting from autoimmune disease.	Creatinine	45-55	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	15-18
17943082-7	2008	The area of the EGF/MCP-1 ratio was significantly higher than that of EGF or MCP-1 alone, histologic grade, creatinine clearance, or proteinuria.	Creatinine	108-118	epidermal growth factor	Homo sapiens	16-19
17943082-7	2008	The area of the EGF/MCP-1 ratio was significantly higher than that of EGF or MCP-1 alone, histologic grade, creatinine clearance, or proteinuria.	Creatinine	108-118	C-C motif chemokine ligand 2	Homo sapiens	20-25
17704114-2	2007	The aim of this study was to evaluate the kidney weight and its relationship to creatinine clearance (CrCl) after 12 months post-transplantation.	Creatinine	80-90	CRCL	Homo sapiens	102-106
18001477-9	2007	Benefit in cluster 2 was unexpectedly associated with NAC-induced decreases in creatinine from baseline (p = 0.07).	Creatinine	79-89	synuclein alpha	Homo sapiens	54-57
17961312-6	2007	RESULTS: The mean values of uP1 were 4.62 +/- 4.82 (mean +/- standard deviation) ng/mol creatinine.	Creatinine	88-98	secretoglobin family 1A member 1	Homo sapiens	28-31
18955361-8	2011	In conclusion, ACE reduced urine protein and creatinine levels and suppressed the thickening of the kidney glomerular basement membrane, suggesting that ACE protects the kidney from immunological damage resulting from autoimmune disease.	Creatinine	45-55	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	153-156
21712961-4	2011	Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 +- 6.5 ng/mmol creatinine) as compared to the controls (16.9 +- 4.0 ng/mmol creatinine) (P&lt;.001).	Creatinine	106-116	serpin family B member 3	Homo sapiens	72-75
21712961-4	2011	Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 +- 6.5 ng/mmol creatinine) as compared to the controls (16.9 +- 4.0 ng/mmol creatinine) (P&lt;.001).	Creatinine	167-177	serpin family B member 3	Homo sapiens	72-75
20437404-7	2011	Median urinary TGF-beta1 and MCP- 1 levels were 0.3 (range 0.0-28.1) and 18 (range 3-370) ng/mmol of creatinine, respectively.	Creatinine	101-111	C-C motif chemokine ligand 2	Homo sapiens	29-35
20437404-8	2011	Urinary protein and MCP-1 to creatinine ratios were associated with slope, and this applied to both diabetic and nondiabetic patients separately.	Creatinine	29-39	C-C motif chemokine ligand 2	Homo sapiens	20-25
21349949-10	2011	Significant predictors of CRH included having a comorbidity score of 3-4 versus 0 and having a higher creatinine level.	Creatinine	102-112	corticotropin releasing hormone	Homo sapiens	26-29
17768112-3	2007	Urinary hepcidin increased from zero at baseline, when hemoglobin and serum transferrin was low, to a maximum of 98 ng/mg creatinine on day 60, and subsequently decreased.	Creatinine	122-132	hepcidin antimicrobial peptide	Homo sapiens	8-16
17329141-8	2007	A significant negative relationship was observed between creatinine clearance and serum IGFBP-1 level (r=-0.39, p=0.004).	Creatinine	57-67	insulin like growth factor binding protein 1	Homo sapiens	88-95
17329141-10	2007	On the other hand, IGFBP-1 was negatively related with creatinine clearance and positively related with the duration of diabetes.	Creatinine	55-65	insulin like growth factor binding protein 1	Homo sapiens	19-26
17329141-12	2007	Further studies are needed to clarify a potential role of increased levels of IGFBP-1 in decreased creatinine clearance in type 2 DM.	Creatinine	99-109	insulin like growth factor binding protein 1	Homo sapiens	78-85
17032712-2	2007	OBJECTIVE: The objective of the study was to examine the association between creatinine clearance (CrCl) and the incidence of falls and fallers in groups treated with placebo, calcitriol, estrogen therapy (ET)/estrogen + progestin therapy (HT), and calcitriol + ET/HT.	Creatinine	77-87	CRCL	Homo sapiens	99-103
16966829-8	2006	Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r(2) = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r(2) = 0.851).	Creatinine	54-64	C-C motif chemokine ligand 2	Homo sapiens	220-225
17175295-8	2006	Upon univariate analysis resistin levels in kidney allograft recipients were related to hsCRP, IL-6, thrombomodulin, red blood cell count, white blood cell count, platelet count, creatinine, urea, VCAM, CSA, dose and eGFR.	Creatinine	179-189	resistin	Homo sapiens	25-33
17175295-9	2006	Upon multiple regression analysis, resistin was independently related only to creatinine, hsCRP, and white blood cell count in kidney allograft recipients.	Creatinine	78-88	resistin	Homo sapiens	35-43
16929540-8	2006	In patients with chronic renal failure, hepcidin correlated significantly with total protein, albumin, creatinine, and eGRF.	Creatinine	103-113	hepcidin antimicrobial peptide	Homo sapiens	40-48
16929540-9	2006	In kidney transplant recipients, hepcidin correlated significantly in univariate analysis, with total protein, ferritin, time after transplantation, creatinine, eGRF and tended to correlate with cholesterol.	Creatinine	149-159	hepcidin antimicrobial peptide	Homo sapiens	33-41
20507276-14	2010	Nevertheless, other studies are also needed to understand the mechanism and the implications of the moderate homocysteine and creatinine elevations with fenofibrate and other PPARalpha agonists.	Creatinine	126-136	peroxisome proliferator activated receptor alpha	Homo sapiens	175-184
16860177-7	2006	This led to an improvement of the renal function with a reduction of serum and urinary M-protein (serum creatinine 1.4 mg/dL; serum IgGkappa M-protein, 2.9 g/dL; proteinuria, 2 g/d; kappa light-chain level in urine, 0.7 g/L).	Creatinine	104-114	myomesin 2	Homo sapiens	87-96
16631666-3	2006	METHODS: To assess the relationship between renal function and LVAD use, changes in creatinine clearances (CrCl, in mL/min) were assessed retrospectively in 220 patients who underwent LVAD placement.	Creatinine	84-94	CRCL	Homo sapiens	107-111
20551909-8	2010	At 24 hours postinjury, despite equivalent levels of tubular necrosis, apoptosis, and capillary density between groups, the injection of Ad-HO-1 M phi resulted in preserved renal function (serum creatinine reduced by 46%), and reduced microvascular platelet deposition.	Creatinine	195-205	heme oxygenase 1	Homo sapiens	140-144
20651198-12	2010	Creatinine after administration of contrast material was associated with sex and mSOFA (p = 0.04 and 0.02, respectively) but not baseline creatinine.	Creatinine	0-10	phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)	Mus musculus	81-86
16298359-2	2006	beta2MG-uria was defined by a cutoff point of 1000 microg beta2-microglobulin/g creatinine.	Creatinine	80-90	beta-2-microglobulin	Homo sapiens	58-77
16430721-11	2006	The change in IGFBP-3 was inversely correlated to the change in creatinine clearance (r=-0.4; P=0.02).	Creatinine	64-74	insulin like growth factor binding protein 3	Homo sapiens	14-21
16430721-13	2006	Furthermore, changes in total IGF-I and IGFBP-3 correlated to changes in serum creatinine levels in the metabolically stable patients (r=0.58, P=0.02 and r=0.6, P=0.01, respectively).	Creatinine	79-89	insulin like growth factor binding protein 3	Homo sapiens	40-47
16509458-11	2006	The association between t-hcy and tissue factor persisted after these two parameters were adjusted for creatinine (r: 0.649 p &lt; 0.05).	Creatinine	103-113	coagulation factor III, tissue factor	Homo sapiens	34-47
20620527-7	2010	Hepcidin correlated with total iron binding capacity, ferritin, IL-6, hemoglobin, erythrocyte count, cystatin C, NT-proBNP, creatinine, and GFR.	Creatinine	124-134	hepcidin antimicrobial peptide	Homo sapiens	0-8
16418789-10	2006	Elevated PINP or CTx was significantly correlated with high PTH, creatinine, and albumin in both genders, except for albumin in women.	Creatinine	65-75	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	17-20
20081092-4	2010	Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types.	Creatinine	82-92	hepcidin antimicrobial peptide	Homo sapiens	41-49
19961832-9	2010	EPO resulted in less severe tissue injury and ameliorated the elevation in creatinine and urea nitrogen levels 24h after reperfusion.	Creatinine	75-85	erythropoietin	Rattus norvegicus	0-3
20486990-11	2010	We found a direct association between OPN and other markers of renal function (serum-creatinine, homocysteine and symmetric dimethylarginine,) as well as with cardiovascular risk factors such as asymmetric dimethylarginine (r = 0.36, P = 0.0213).	Creatinine	85-95	secreted phosphoprotein 1	Homo sapiens	38-41
20305092-1	2010	Dose-response expression of kidney injury molecule-1 (KIM-1) gene in kidney cortex and its correlation with morphology and traditional biomarkers of nephrotoxicity (plasma creatinine and blood urea nitrogen, BUN) or segment-specific marker of proximal tubule injury (kidney glutamine synthetase, GSK) were studied in male rats treated with proximal tubule segment-specific nephrotoxicants.	Creatinine	172-182	hepatitis A virus cellular receptor 1	Rattus norvegicus	28-52
20305092-1	2010	Dose-response expression of kidney injury molecule-1 (KIM-1) gene in kidney cortex and its correlation with morphology and traditional biomarkers of nephrotoxicity (plasma creatinine and blood urea nitrogen, BUN) or segment-specific marker of proximal tubule injury (kidney glutamine synthetase, GSK) were studied in male rats treated with proximal tubule segment-specific nephrotoxicants.	Creatinine	172-182	hepatitis A virus cellular receptor 1	Rattus norvegicus	54-59
20222955-0	2010	A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.	Creatinine	127-137	collagen type XXII alpha 1 chain	Homo sapiens	90-97
20222955-0	2010	A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.	Creatinine	127-137	gamma-aminobutyric acid type A receptor subunit rho2	Homo sapiens	109-115
20007348-10	2010	In experimental models of renal IRI, deficiency in clusterin expression worsened the injury, as indicated by a significant increase in renal tissue damage with higher levels of serum creatinine and blood urea nitrogen and by a poorer recovery from the injury in clusterin-deficient mice compared with wild-type mice.	Creatinine	183-193	clusterin	Mus musculus	51-60
16221709-11	2006	The EPO-treated group had significantly lower serum and creatinine levels.	Creatinine	56-66	erythropoietin	Rattus norvegicus	4-7
19733522-14	2009	Thirty-four grafts fared well with an average serum creatinine level respectively of 107, 124, 125micromol/l at 1, 2, 3 and 4 years after transplantation.	Creatinine	52-62	solute carrier family 7 member 5	Homo sapiens	107-125
19919977-4	2009	Compared with time-matched controls, separate Ucn2 and furosemide administration significantly increased urine output (furosemide&gt;Ucn2), urine sodium (furosemide&gt;Ucn2), potassium (furosemide&gt;Ucn2), and creatinine excretion (Ucn2&gt;furosemide) and creatinine clearance (Ucn2&gt;furosemide).	Creatinine	211-221	urocortin-2	Ovis aries	46-50
19919977-4	2009	Compared with time-matched controls, separate Ucn2 and furosemide administration significantly increased urine output (furosemide&gt;Ucn2), urine sodium (furosemide&gt;Ucn2), potassium (furosemide&gt;Ucn2), and creatinine excretion (Ucn2&gt;furosemide) and creatinine clearance (Ucn2&gt;furosemide).	Creatinine	257-267	urocortin-2	Ovis aries	46-50
18716607-7	2009	Plasma BuChE activity, a non-adverse biomarker of exposure, was negatively related to urinary TCPy concentrations above approximately 110 microg TCPy/g Cr.	Creatinine	152-154	butyrylcholinesterase	Homo sapiens	7-12
16902321-8	2006	To conclude, the observed increase in urine osmolality and creatinine clearance during the diuretic phase, paralleled by an increase in total AQP2 excretion, suggests that AQP2 can contribute to the urinary concentrating ability early in postnatal life.	Creatinine	59-69	aquaporin 2	Homo sapiens	172-176
16310567-5	2005	In patients with normal renal function (serum creatinine level &lt; 1.5 mg/dL [&lt; 135 micromol/L]), risk for developing end-stage renal disease can be estimated by measuring urinary excretion of beta2-microglobulin or alpha1-microglobulin and immunoglobulin G. For low-risk patients, a wait-and-see policy is advised.	Creatinine	46-56	beta-2-microglobulin	Homo sapiens	197-216
19437088-8	2009	IgG a-B2GPI was significantly negatively associated with creatinine clearance according to the Cockcroft-Gault (p = 0.03) and MDRD (p = 0.01) formula.	Creatinine	57-67	apolipoprotein H	Homo sapiens	6-11
16303000-4	2005	Creatinine clearance (CrCl) was estimated by the Cockroft-Gault formula.	Creatinine	0-10	CRCL	Homo sapiens	22-26
16249921-3	2005	In the average, hepcidin transiently increased at day 1 from 32 to 85 ng/mg creatinine.	Creatinine	76-86	hepcidin antimicrobial peptide	Homo sapiens	16-24
19210685-5	2009	Median creatinine levels were significantly lower in IGL-1 group from day 6 to day 14 and it decreased more rapidly in the IGL-1 group (from day 4 to day 15: p &lt; 0.05).	Creatinine	7-17	immunoglobulin lambda like polypeptide 1	Homo sapiens	53-58
19210685-6	2009	Creatinine clearance values were usually higher in the IGL-1 group for the first 15 d. During the follow-up period serum creatinine concentrations were lower in IGL-1 group at one, three, six and 12 months after transplantation (p = 0.04; p = 0.06, p = 0.01 and p = 0.08, respectively) while creatinine clearance values were similar during the follow-up.	Creatinine	0-10	immunoglobulin lambda like polypeptide 1	Homo sapiens	55-60
19210685-6	2009	Creatinine clearance values were usually higher in the IGL-1 group for the first 15 d. During the follow-up period serum creatinine concentrations were lower in IGL-1 group at one, three, six and 12 months after transplantation (p = 0.04; p = 0.06, p = 0.01 and p = 0.08, respectively) while creatinine clearance values were similar during the follow-up.	Creatinine	0-10	immunoglobulin lambda like polypeptide 1	Homo sapiens	161-166
19210685-6	2009	Creatinine clearance values were usually higher in the IGL-1 group for the first 15 d. During the follow-up period serum creatinine concentrations were lower in IGL-1 group at one, three, six and 12 months after transplantation (p = 0.04; p = 0.06, p = 0.01 and p = 0.08, respectively) while creatinine clearance values were similar during the follow-up.	Creatinine	121-131	immunoglobulin lambda like polypeptide 1	Homo sapiens	161-166
19404953-6	2009	RESULTS: Based on the mean-mean common or the mean-max CIMT as the dependent variable, univariable analysis showed significant associations of the following variables with increased CIMT: increasing age, longer SLE duration, minority status, higher body mass index (BMI), male sex, increased creatinine clearance, higher lipoprotein(a) level, proteinuria, azathioprine treatment, and prednisone dose.	Creatinine	292-302	CIMT	Homo sapiens	182-186
16251240-8	2005	rAAV1-IL-10 treatment resulted in less proteinuria (P &lt; 0.05), lower serum creatinine (P &lt; 0.05), and higher creatinine clearances (P &lt; 0.01) compared with rAAV1-GFP-treated rats.	Creatinine	78-88	interleukin 10	Rattus norvegicus	6-11
16251240-8	2005	rAAV1-IL-10 treatment resulted in less proteinuria (P &lt; 0.05), lower serum creatinine (P &lt; 0.05), and higher creatinine clearances (P &lt; 0.01) compared with rAAV1-GFP-treated rats.	Creatinine	115-125	interleukin 10	Rattus norvegicus	6-11
16294264-11	2005	CrCl was estimated by the Cockcroft and Gault method, based on age, weight, and serum creatinine.	Creatinine	86-96	CRCL	Homo sapiens	0-4
16260911-2	2005	Twelve weeks after initiating a tenofovir-containing HAART regimen, a high urine-beta 2 microglobulin level was observed in 12 out of 17 patients, the percentage of tubular reabsorption of phosphate decreased from 96.0 to 91.1% and alkaline phosphatase increased from 294 to 365 U/l, whereas serum creatinine and phosphorus remained largely unchanged.	Creatinine	298-308	beta-2-microglobulin	Homo sapiens	81-101
15892146-5	2005	Amidine HFiso reacts in a 1:1 ratio with [AlH3(NMe3)] to give the unusual hydride-bridging dimeric complex, [{AlH2(Fiso)}2], in which the Fiso- ligand is nonchelating.	Creatinine	74-81	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	47-51
16052399-5	2005	Eight women with pregnancy-induced antithrombin deficiency, including three women with gestational thrombocytopenia, were significantly more likely to develop perinatal elevations of AST, lactate dehydrogenase, serum creatinine, fibrin/fibrinogen degradation products, and D-dimer than were those without pregnancy-induced antithrombin deficiency.	Creatinine	217-227	serpin family C member 1	Homo sapiens	35-47
15964364-9	2005	RESULTS: Leptin correlated with the percentage of body fat, trunk fat, lean body mass, serum creatinine, and urea.	Creatinine	93-103	leptin	Homo sapiens	9-15
19404953-9	2009	BMI (P&lt;0.001) and creatinine clearance (P=0.031) remained associated with increased mean-mean common CIMT, while increasing age (P&lt;0.001) and increasing lipoprotein(a) level (P=0.005) were associated with increased mean-max CIMT.	Creatinine	21-31	CIMT	Homo sapiens	104-108
19404953-9	2009	BMI (P&lt;0.001) and creatinine clearance (P=0.031) remained associated with increased mean-mean common CIMT, while increasing age (P&lt;0.001) and increasing lipoprotein(a) level (P=0.005) were associated with increased mean-max CIMT.	Creatinine	21-31	CIMT	Homo sapiens	230-234
19361749-2	2009	GFR is often estimated by measurement of creatinine clearance in a 24-hour urine collection (24-hr CrCl), an inconvenient and error-prone method that overestimates GFR.	Creatinine	41-51	CRCL	Homo sapiens	99-103
19156770-1	2009	The present report describes the use of MEKC in the presence of 35 mM sodium tetraborate, pH 9.0, containing 60 mM SDS for the complete separation and identification of creatinine, 1-methylhistidine (1-MeH) and 3-MeH in human urine.	Creatinine	169-179	epoxide hydrolase 1	Homo sapiens	213-216
15522986-6	2005	Creatinine clearance was 63% lower in THP -/- than in WT mice (P &lt; 0.05).	Creatinine	0-10	uromodulin	Mus musculus	38-41
15931648-6	2005	RESULTS: AQP3 mRNA expression in PDE correlated closely with peritoneal transport characteristics, including dialysate-to-plasma creatinine (Cr) ratio at 4 hr (D/P4) (r=0.42, p=0.007), mass transfer area coefficient (MTAC) of Cr (r=0.60, p&lt;0.0001), and net ultrafiltration (UF) (r=0.34, p=0.03).	Creatinine	129-139	aquaporin 3 (Gill blood group)	Homo sapiens	9-13
15931648-6	2005	RESULTS: AQP3 mRNA expression in PDE correlated closely with peritoneal transport characteristics, including dialysate-to-plasma creatinine (Cr) ratio at 4 hr (D/P4) (r=0.42, p=0.007), mass transfer area coefficient (MTAC) of Cr (r=0.60, p&lt;0.0001), and net ultrafiltration (UF) (r=0.34, p=0.03).	Creatinine	141-143	aquaporin 3 (Gill blood group)	Homo sapiens	9-13
15931648-6	2005	RESULTS: AQP3 mRNA expression in PDE correlated closely with peritoneal transport characteristics, including dialysate-to-plasma creatinine (Cr) ratio at 4 hr (D/P4) (r=0.42, p=0.007), mass transfer area coefficient (MTAC) of Cr (r=0.60, p&lt;0.0001), and net ultrafiltration (UF) (r=0.34, p=0.03).	Creatinine	226-228	aquaporin 3 (Gill blood group)	Homo sapiens	9-13
15838465-5	2005	Patients were excluded if the TnT increase was associated with a significant increase of serum creatinine (&gt; or =50%) with no other evidence of myocardial ischemia.	Creatinine	95-105	troponin T1, slow skeletal type	Homo sapiens	30-33
15705997-8	2005	Urinary leukotriene E(4) in the zileuton group (n = 9) decreased from 67 +/- 35 pg/mg creatinine at sea level to 33 +/- 22 pg/mg creatinine at high altitude (p = 0.003) [mean +/- SD].	Creatinine	86-96	ubiquitination factor E4A	Homo sapiens	20-24
15705997-8	2005	Urinary leukotriene E(4) in the zileuton group (n = 9) decreased from 67 +/- 35 pg/mg creatinine at sea level to 33 +/- 22 pg/mg creatinine at high altitude (p = 0.003) [mean +/- SD].	Creatinine	129-139	ubiquitination factor E4A	Homo sapiens	20-24
15705997-9	2005	Urinary leukotriene E(4) in the placebo group (n = 9) decreased from 97 +/- 82 pg/mg creatinine at sea level to 44 +/- 21 pg/mg creatinine at high altitude (p = 0.045).	Creatinine	85-95	ubiquitination factor E4A	Homo sapiens	20-24
15705997-9	2005	Urinary leukotriene E(4) in the placebo group (n = 9) decreased from 97 +/- 82 pg/mg creatinine at sea level to 44 +/- 21 pg/mg creatinine at high altitude (p = 0.045).	Creatinine	128-138	ubiquitination factor E4A	Homo sapiens	20-24
18951868-9	2009	Urinary hepcidin levels of 3 to 9 nmol/mmol creatinine(-1) were found in healthy controls, with reduced levels in hemochromatosis (P&lt;0.00006) and elevated levels in inflammation (P&lt;0.00035).	Creatinine	44-54	hepcidin antimicrobial peptide	Homo sapiens	8-16
19183077-2	2009	The first case, a 16-year-old African American male with an absolute CD4+ cell count of 314 cells/mm(3), presented with an abrupt rise in serum creatinine leading to irreversible renal failure while on TDF-containing highly active antiretroviral therapy (HAART).	Creatinine	144-154	sex determining region Y	Homo sapiens	202-205
15163337-8	2004	In contrast, patients with active eye disease (CAS = 3, n = 27) had uGAGs (8.4 +/- 2.7 micro g/mg/creatinine) and sHA (32.3 +/- 17.8 micro g/l) 2-3 times higher than those patients with inactive eye disease.	Creatinine	98-108	embryonal Fyn-associated substrate	Homo sapiens	47-54
15212162-0	2004	Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.	Creatinine	0-10	solute carrier family 22 member 2	Homo sapiens	63-68
15212162-3	2004	METHODS: Transport of [14C]creatinine by human organic ion transporters (SLC22A) was assessed by HEK293 cells expressing hOCT1, hOCT2, hOCT2-A, hOAT1, and hOAT3.	Creatinine	27-37	solute carrier family 22 member 2	Homo sapiens	128-133
15212162-3	2004	METHODS: Transport of [14C]creatinine by human organic ion transporters (SLC22A) was assessed by HEK293 cells expressing hOCT1, hOCT2, hOCT2-A, hOAT1, and hOAT3.	Creatinine	27-37	solute carrier family 22 member 2	Homo sapiens	135-140
15212162-3	2004	METHODS: Transport of [14C]creatinine by human organic ion transporters (SLC22A) was assessed by HEK293 cells expressing hOCT1, hOCT2, hOCT2-A, hOAT1, and hOAT3.	Creatinine	27-37	solute carrier family 22 member 6	Homo sapiens	144-149
15212162-3	2004	METHODS: Transport of [14C]creatinine by human organic ion transporters (SLC22A) was assessed by HEK293 cells expressing hOCT1, hOCT2, hOCT2-A, hOAT1, and hOAT3.	Creatinine	27-37	solute carrier family 22 member 8	Homo sapiens	155-160
15212162-4	2004	RESULTS: Among the organic ion transporters examined, only hOCT2 stimulated creatinine uptake when expressed in HEK293 cells.	Creatinine	76-86	solute carrier family 22 member 2	Homo sapiens	59-64
15212162-5	2004	Creatinine uptake by hOCT2 was dependent on the membrane potential.	Creatinine	0-10	solute carrier family 22 member 2	Homo sapiens	21-26
15212162-6	2004	The Michaelis constant (Km) for creatinine transport by hOCT2 was 4.0 mM, suggesting low affinity.	Creatinine	32-42	solute carrier family 22 member 2	Homo sapiens	56-61
15212162-7	2004	Various cationic drugs including cimetidine and trimethoprim, but not anionic drugs, markedly inhibited creatinine uptake by hOCT2.	Creatinine	104-114	solute carrier family 22 member 2	Homo sapiens	125-130
15212162-8	2004	CONCLUSION: These results suggest that hOCT2, but not hOCT1, is responsible for the basolateral membrane transport of creatinine in the human kidney.	Creatinine	118-128	solute carrier family 22 member 2	Homo sapiens	39-44
15058777-7	2004	Calves with high serum TNF concentration had significantly lower mean IgG (P &lt; .001), globulin (P &lt; .0001), and calcium (P &lt; .0001) concentrations; greater serum creatinine concentrations (P &lt; .0001); and &gt; or = 2+ toxic changes in neutrophils than did calves without high serum TNF concentrations.	Creatinine	171-181	tumor necrosis factor	Bos taurus	23-26
14966968-1	2004	Hydride complexes [FeH(N-N)P3]BPh4 (1, 2) [N-N = 2,2"-bipyridine (bpy) and 1,10-phenanthroline (phen); P = P(OEt)4, PPh(OEt)2, and PPh2OEt] were prepared by allowing FeCl2(N-N) to react with phosphite in the presence of NaBH4.	Creatinine	0-7	enolase 1	Homo sapiens	116-119
12972106-5	2003	Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault equation.	Creatinine	0-10	CRCL	Homo sapiens	22-26
14504195-5	2003	IGF-I, IGF-II, and IGF binding protein-3 were inversely associated with the presence of neonatal jaundice and blood creatinine, after controlling for blood protein levels.	Creatinine	116-126	insulin like growth factor 2	Homo sapiens	7-13
14504195-5	2003	IGF-I, IGF-II, and IGF binding protein-3 were inversely associated with the presence of neonatal jaundice and blood creatinine, after controlling for blood protein levels.	Creatinine	116-126	insulin like growth factor binding protein 3	Homo sapiens	19-40
19921985-9	2009	The correlation between urinary CTGF concentration and serum creatinine (SCr) and Banff score was analysed statistically.	Creatinine	61-71	cellular communication network factor 2	Rattus norvegicus	32-36
19104409-5	2008	RESULTS: Compared with wild-type mice, Cd73 null mice showed reduced levels of serum creatinine and urea, apoptosis of renal cells, and histologic damage after I/RI.	Creatinine	85-95	5' nucleotidase, ecto	Mus musculus	39-43
12937307-2	2003	It was previously shown that patients with low creatinine production were malnourished and had low serum creatinine levels and creatinine clearances (CrCl) but high MDRD GFR at initiation of dialysis.	Creatinine	47-57	CRCL	Homo sapiens	150-154
12854633-4	2003	There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P = 0.036).	Creatinine	57-67	enolase 1	Homo sapiens	95-98
12821233-9	2003	In the NAC group, mean serum creatinine fell from 1.85 +/- 0.59 to 1.77 +/- 0.73 and 1.79 +/- 0.73 mg/dl 48 h and four days post-contrast (p = 0.02 and 0.023 vs. baseline, respectively).	Creatinine	29-39	synuclein alpha	Homo sapiens	7-10
18829738-4	2008	IMD administration significantly lowered blood pressure, increased urine volume, and restored creatinine clearance.	Creatinine	94-104	adrenomedullin 2	Rattus norvegicus	0-3
18621861-8	2008	Salt-loaded rats given PRAM-1 for 8 wk demonstrated (1) reduced serum creatinine level, (2) decreased left ventricular mass, (3) improved left ventricular function, and (4) reduced left ventricular fibrosis.	Creatinine	70-80	PML-RARA regulated adaptor molecule 1	Rattus norvegicus	23-29
12778478-6	2003	Only the treatment with apoptotic B cells promoted a systemic Th2 autoimmune response to H2 histones, associated with earlier occurrence of high levels of anti-dsDNA autoantibodies, higher creatinine levels and more numerous glomerular IgG deposits than in BW controls not injected with apoptotic B cells.	Creatinine	189-199	heart and neural crest derivatives expressed 2	Mus musculus	62-65
12862205-4	2003	We calculated the ratio of the concentration of thrombomodulin to that of creatinine, because soluble thrombomodulin is excreted by the kidney and the serum level of thrombomodulin was correlated with that of creatinine (p &lt; 0.05).	Creatinine	74-84	thrombomodulin	Homo sapiens	102-116
12862205-4	2003	We calculated the ratio of the concentration of thrombomodulin to that of creatinine, because soluble thrombomodulin is excreted by the kidney and the serum level of thrombomodulin was correlated with that of creatinine (p &lt; 0.05).	Creatinine	74-84	thrombomodulin	Homo sapiens	102-116
12862205-4	2003	We calculated the ratio of the concentration of thrombomodulin to that of creatinine, because soluble thrombomodulin is excreted by the kidney and the serum level of thrombomodulin was correlated with that of creatinine (p &lt; 0.05).	Creatinine	209-219	thrombomodulin	Homo sapiens	48-62
14610342-9	2003	The TF and TFPI levels depend significantly on the renal function, as assessed by serum creatinine, and on some metabolic disorders.	Creatinine	88-98	coagulation factor III, tissue factor	Homo sapiens	4-6
14608855-12	2003	We noticed correlation between creatinine clearance values and values of serum beta 2 microglobulin (r = = .56; p = = .0002; Figure 1).	Creatinine	31-41	beta-2-microglobulin	Homo sapiens	79-99
14608855-13	2003	It has been documented that with decreased of creatinine clearance values, serum values of beta 2 microglobulin increased, in chronic renal failure /22/.	Creatinine	46-56	beta-2-microglobulin	Homo sapiens	91-111
12557752-5	2002	The patients with a beta 2M &lt; or = 4 mg/ml had serum creatinine levels lower than those with beta 2M &gt; 4 (1.43 vs 2.67 mg/dl; p = 0.02).	Creatinine	56-66	beta-2-microglobulin	Homo sapiens	20-27
18544473-7	2008	Anti-C1q positive patients had significantly higher proteinuria and serum creatinine as well as more often oliguria, hypertension and delayed resolution of the disease than patients without anti-C1q.	Creatinine	74-84	complement C1q A chain	Homo sapiens	5-8
18983285-1	2008	The American Diabetes Association and the National Kidney Foundation define microalbuminuria as an albumin (microg)/creatinine (mg) ratio (ACR) between 30 and 300 microg/mg regardless of sex.	Creatinine	116-126	acrosin	Homo sapiens	139-142
18535924-3	2008	Using rats subjected to renal I/R by occlusion of bilateral renal pedicles, we found that administration of ApoA-I significantly reduced serum creatinine levels, serum TNF-alpha and IL-1beta levels as well as tissue myeloperoxidase (MPO) activity, compared with I/R controls.	Creatinine	143-153	apolipoprotein A1	Rattus norvegicus	108-114
18480171-4	2008	IRI was induced by clamping the renal pedicle of C57BL/6 mice for 45 min at 32 degrees C. Here, we demonstrate upregulation of IDO in renal tissue at 2 h after reperfusion which reached maximal levels at 24 h. Inhibition of IDO following IRI prevented the increase in serum creatinine observed in vehicle-treated mice (86.4 +/- 25 micromol/l, n = 11) compared with mice treated with 1-methyl-D-tryptophan, a specific inhibitor of IDO (33.7 +/- 8.7 micromol/l, n = 10, P = 0.031).	Creatinine	274-284	indoleamine 2,3-dioxygenase 1	Mus musculus	127-130
12368200-9	2002	In anti-VLA-1-treated rats, serum creatinine was significantly lower at day 32 (P = 0.002) and renal survival was significantly better (P = 0.045).	Creatinine	34-44	integrin subunit alpha 1	Rattus norvegicus	8-13
12354436-1	2002	OBJECTIVES: The goal of this study was to determine the prognostic significance of estimated creatinine clearance (CrCl) in relation to 6-min walk distance in ambulatory patients with congestive heart failure (HF).	Creatinine	93-103	CRCL	Homo sapiens	115-119
18455331-7	2008	Uptake of TCr during the shift was confirmed for welders of SS by a median increase of urinary TCr from pre- to post-shift of 0.30 microg/g creatinine.	Creatinine	140-150	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	10-13
18455331-7	2008	Uptake of TCr during the shift was confirmed for welders of SS by a median increase of urinary TCr from pre- to post-shift of 0.30 microg/g creatinine.	Creatinine	140-150	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	95-98
18437151-7	2008	Furthermore, AFABP serum levels correlated positively with age, body mass index (BMI), blood pressure, serum creatinine, free fatty acids (FFAs), leptin, and C-reactive protein (CRP).	Creatinine	109-119	fatty acid binding protein 4	Homo sapiens	13-18
18437151-8	2008	In multivariate analyses, BMI and serum creatinine remained independently associated with AFABP concentrations and explained 58% of the variation in AFABP levels.	Creatinine	40-50	fatty acid binding protein 4	Homo sapiens	90-95
18437151-8	2008	In multivariate analyses, BMI and serum creatinine remained independently associated with AFABP concentrations and explained 58% of the variation in AFABP levels.	Creatinine	40-50	fatty acid binding protein 4	Homo sapiens	149-154
18437151-10	2008	Furthermore, BMI and serum creatinine are independent predictors of circulating AFABP.	Creatinine	27-37	fatty acid binding protein 4	Homo sapiens	80-85
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Creatinine	119-129	glutathione S-transferase pi 1	Homo sapiens	42-47
12167597-9	2002	Similarly, the ratios of urinary protein to creatinine and urinary albumin to creatinine, but not urinary guanosine 3",5"-cyclic monophosphate to creatinine, decreased significantly with an LPD.	Creatinine	44-54	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	190-193
12167597-9	2002	Similarly, the ratios of urinary protein to creatinine and urinary albumin to creatinine, but not urinary guanosine 3",5"-cyclic monophosphate to creatinine, decreased significantly with an LPD.	Creatinine	78-88	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	190-193
12167597-9	2002	Similarly, the ratios of urinary protein to creatinine and urinary albumin to creatinine, but not urinary guanosine 3",5"-cyclic monophosphate to creatinine, decreased significantly with an LPD.	Creatinine	78-88	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	190-193
18235151-6	2008	Moreover, percentage change of monocyte chemoattractant protein-1 level correlated positively to that of albumin-to-creatinine ratio.	Creatinine	116-126	C-C motif chemokine ligand 2	Homo sapiens	31-65
18275681-1	2008	BACKGROUND: The aim of the study was to determine the extent of bilirubin interference on two different Beckman-Coulter creatinine methods used on the CX5 PRO/DxC 600 and the DxC 800 systems, respectively.	Creatinine	120-130	cannabinoid receptor 2	Homo sapiens	151-154
11912263-1	2002	The recommended albumin (microg)/creatinine (mg) ratio (ACR) (30 microg/mg) to detect microalbuminuria does not account for sex or racial differences in creatinine excretion.	Creatinine	33-43	acrosin	Homo sapiens	56-59
18024526-3	2008	METHODS: In 263 individuals (161 type 2 diabetic patients and 102 healthy nondiabetic controls), we analyzed the correlation between FABP4 and creatinine or glomerular filtration index (MDRD-GFR) regarding the presence or absence of microalbuminuria.	Creatinine	143-153	fatty acid binding protein 4	Homo sapiens	133-138
12731371-8	2002	Only at creatinine concentration of 10.0-15.5 mg/dL, PLT differences significantly from PLT in control group.	Creatinine	8-18	N-acylethanolamine acid amidase	Homo sapiens	53-56
12731371-8	2002	Only at creatinine concentration of 10.0-15.5 mg/dL, PLT differences significantly from PLT in control group.	Creatinine	8-18	N-acylethanolamine acid amidase	Homo sapiens	88-91
12731371-9	2002	Following HD, creatinine-dependent statistically significant changes were noted in PLT, in comparison to the values obtained before the procedure.	Creatinine	14-24	N-acylethanolamine acid amidase	Homo sapiens	83-86
11581006-6	2001	RESULTS: Urinary leptin excretion in proteinuric patients was significantly higher than in non-proteinuric patients with and without NS and in healthy controls (2.64+/-0.034 microg/g creatinine, 0.026+/-0.05 microg/g creatinine, and 0.073+/-0.11 microg/g creatinine respectively; P&lt;0.001 and P&lt;0.01 respectively compared with controls).	Creatinine	183-193	leptin	Homo sapiens	17-23
11581006-6	2001	RESULTS: Urinary leptin excretion in proteinuric patients was significantly higher than in non-proteinuric patients with and without NS and in healthy controls (2.64+/-0.034 microg/g creatinine, 0.026+/-0.05 microg/g creatinine, and 0.073+/-0.11 microg/g creatinine respectively; P&lt;0.001 and P&lt;0.01 respectively compared with controls).	Creatinine	217-227	leptin	Homo sapiens	17-23
11581006-6	2001	RESULTS: Urinary leptin excretion in proteinuric patients was significantly higher than in non-proteinuric patients with and without NS and in healthy controls (2.64+/-0.034 microg/g creatinine, 0.026+/-0.05 microg/g creatinine, and 0.073+/-0.11 microg/g creatinine respectively; P&lt;0.001 and P&lt;0.01 respectively compared with controls).	Creatinine	217-227	leptin	Homo sapiens	17-23
18024526-6	2008	We observed a significant, direct correlation between FABP4 and creatinine (r = 0.446, P &lt;0.001) and an inverse correlation between FABP4 and MDRD-GFR (r = -0.511, P &lt;0.001) in type 2 diabetic patients, but not in nondiabetic individuals.	Creatinine	64-74	fatty acid binding protein 4	Homo sapiens	54-59
18024526-9	2008	CONCLUSIONS: High FABP4 plasma concentrations are associated with high plasma creatinine and low MDRD-GFR in patients with type 2 diabetes even in the absence of microalbuminuria or clinically relevant alterations of creatinine and MDRD-GFR values.	Creatinine	78-88	fatty acid binding protein 4	Homo sapiens	18-23
18024526-9	2008	CONCLUSIONS: High FABP4 plasma concentrations are associated with high plasma creatinine and low MDRD-GFR in patients with type 2 diabetes even in the absence of microalbuminuria or clinically relevant alterations of creatinine and MDRD-GFR values.	Creatinine	217-227	fatty acid binding protein 4	Homo sapiens	18-23
18854629-6	2008	There was a significantly positive correlation between the serum predominant FLC/serum creatinine ratio and MPC-1(+)CD45(-)CD49e(-) (p&lt;0.05).	Creatinine	87-97	mitochondrial pyruvate carrier 1	Homo sapiens	108-113
17804460-9	2008	RHS-TM significantly decreased blood urea nitrogen and serum creatinine levels.	Creatinine	61-71	thrombomodulin	Homo sapiens	4-6
17978060-5	2007	Urinary hepcidin (intensity/mmol creatinine) was associated with log parasitemia in 86 children (beta = 0.086, standard error [SE] = 0.035, P &lt; 0.017), 31 pregnant women (beta = 0.218, SE = 0.085, P &lt; 0.016), and 82 adults (beta = 0.184, SE =0.043, P &lt; 0.0001).	Creatinine	33-43	hepcidin antimicrobial peptide	Homo sapiens	8-16
18007554-9	2007	The urinary DPPIV activity was similar in patients (1.52 +/- 0.94 U/mmol creatinine) and controls (1.37 +/- 0.68 U/mmol creatinine) (p = 0.861).	Creatinine	73-83	dipeptidyl peptidase 4	Homo sapiens	12-17
17640968-5	2007	PAR-2(-/-) mice had reduced crescent formation, proteinuria, and serum creatinine compared with wild-type mice 21 days after initiation of CGN.	Creatinine	71-81	coagulation factor II (thrombin) receptor-like 1	Mus musculus	0-5
17686058-2	2007	Eight of 14 patients with grade &gt; or =3 myelosuppression had baseline creatinine clearance (CrCl) &lt; or =0.67 ml/s.	Creatinine	73-83	CRCL	Homo sapiens	95-99
17591627-9	2007	Associations between rs743137 (P = 0.05) and rs680638 (P = 0.022) in HMCN1 with calculated creatinine clearance progression were also observed.	Creatinine	91-101	hemicentin 1	Homo sapiens	69-74
17713435-8	2007	At 24 hr after I/R, the Cr (mg/dL) levels in Sham, Vehicle, EPO, and asialoEPO were 0.13+/-0.01, 1.24+/-0.70, 0.24+/-0.08, and 0.25+/-0.13, respectively (P&lt;0.05).	Creatinine	24-26	erythropoietin	Mus musculus	60-63
17692741-2	2007	BACKGROUND: The ratio of the volume of contrast media to the creatinine clearance (V/CrCl) has been shown to correlate with the area under the curve of contrast media concentration over time.	Creatinine	61-71	CRCL	Homo sapiens	85-89
17692741-6	2007	The predictive value of V/CrCl for the risk of an early increase in creatinine was assessed using multivariable logistic regression.	Creatinine	68-78	CRCL	Homo sapiens	26-30
17692741-9	2007	Furthermore, there was a significant association between V/CrCl and an early increase in creatinine (overall and trend, p &lt; 0.001).	Creatinine	89-99	CRCL	Homo sapiens	59-63
17692741-10	2007	The receiver-operator characteristic curve analysis indicated that a V/CrCl ratio of 3.7 was a fair discriminator for the early creatinine increase (C-statistic 0.69).	Creatinine	128-138	CRCL	Homo sapiens	71-75
17692741-11	2007	After adjusting for other known predictors of post-PCI creatinine increase, V/CrCl &gt; or =3.7 remained significantly associated with an early abnormal increase in serum creatinine (odds ratio 3.84; 95% confidence interval 2.0 to 7.3, p &lt; 0.001).	Creatinine	171-181	CRCL	Homo sapiens	78-82
17692741-12	2007	CONCLUSIONS: A V/CrCl ratio &gt;3.7 was a significant and independent predictor of an early abnormal increase in serum creatinine after PCI in this unselected patient population.	Creatinine	119-129	CRCL	Homo sapiens	17-21
17298994-12	2007	CCR1 mRNA was significantly increased in renal biopsies with acute allograft rejection (P &lt; 0.001), and with chronic allograft nephropathy (P &lt; 0.05), it correlated with the expression of CCL3 and CCL5, and with serum-creatinine.	Creatinine	224-234	C-C motif chemokine ligand 3	Homo sapiens	194-198
17306244-3	2007	On Vitros (Clinical Ortho-Diagnostics, Rochester, NY) chemistry analyzer, we observed an overestimation in calculated creatinine clearance (CrCl) and Kt/V(urea) in some children that led us to investigate into methodology used for these assays.	Creatinine	118-128	CRCL	Homo sapiens	140-144
17380301-5	2007	Additionally, a multiple regression analysis indicates that among LDL, TG, HDL, total cholesterol, CRP, creatinine and glucose levels, the only variable significantly affecting p66((ShcA)) and PTX3 mRNA expressions either in adipose tissue or in WBCs is represented by the circulating amount of LDL.	Creatinine	104-114	DNA polymerase delta 3, accessory subunit	Homo sapiens	177-180
11485918-10	2001	Thereafter, damaged glomeruli gradually recovered after development of capillary network by week 8, and significant improvement of renal function was evident in the VEGF-treated group during week 8 (creatinine: VEGF(165), 0.3 +/- 0.1; control, 2.6 +/- 0.9 mg/dl, P &lt; 0.001; proteinuria: VEGF(165), 54 +/- 15; control, 318 +/- 60 mg/day, P &lt; 0.001).	Creatinine	199-209	vascular endothelial growth factor A	Rattus norvegicus	165-169
11531928-4	2001	Urinary excretion of AQP-2 under ad libitum water drinking was 41.1 fmol/micromol creatinine in the patient group, a value significantly greater than that of 21.7 fmol/micromol creatinine in the control subjects.	Creatinine	82-92	aquaporin 2	Homo sapiens	21-26
11531928-4	2001	Urinary excretion of AQP-2 under ad libitum water drinking was 41.1 fmol/micromol creatinine in the patient group, a value significantly greater than that of 21.7 fmol/micromol creatinine in the control subjects.	Creatinine	177-187	aquaporin 2	Homo sapiens	21-26
17259071-5	2007	Urinary leukotriene E4 and leukotriene B4 glucuronide concentrations in 13 normal healthy adults were 94.6 pg/mg-creatinine (median) and 22.3 pg/mg-creatinine, respectively.	Creatinine	113-123	ubiquitination factor E4B	Homo sapiens	20-53
11046208-13	2000	Urinary IL-1ra correlated with urinary NAG/creatinine ratio after cross-clamp release and 2 and 6 h after CPB (P &lt; 0.05).	Creatinine	43-53	interleukin 1 receptor antagonist	Homo sapiens	8-14
17259071-5	2007	Urinary leukotriene E4 and leukotriene B4 glucuronide concentrations in 13 normal healthy adults were 94.6 pg/mg-creatinine (median) and 22.3 pg/mg-creatinine, respectively.	Creatinine	148-158	ubiquitination factor E4B	Homo sapiens	20-53
11044243-16	2000	The number of TBM disruptions correlated with the serum creatinine at the time of biopsy, a combined Banff t + i score, the difference in tubular atrophy between the initial and most recent biopsy and the difference between the nadir creatinine and most recent creatinine.	Creatinine	56-66	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	14-17
17270090-6	2007	RESULTS: Following intake of cooked meat, median serum creatinine concentration (kinetic Jaffe) increased from 80.5 micromol/L preprandially to 101.0 micromol/L 1-2 h postprandially (P&lt;0.0001), and 99.0 micromol/L 3-4 h postprandially (P&lt;0.0001).	Creatinine	55-65	ribosomal protein L34	Homo sapiens	215-220
11044243-16	2000	The number of TBM disruptions correlated with the serum creatinine at the time of biopsy, a combined Banff t + i score, the difference in tubular atrophy between the initial and most recent biopsy and the difference between the nadir creatinine and most recent creatinine.	Creatinine	234-244	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	14-17
11044243-16	2000	The number of TBM disruptions correlated with the serum creatinine at the time of biopsy, a combined Banff t + i score, the difference in tubular atrophy between the initial and most recent biopsy and the difference between the nadir creatinine and most recent creatinine.	Creatinine	234-244	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	14-17
17910281-9	2007	Similarly, elevated beta2-MG (microg/mmol creatinine) levels were also observed in group B compared to both group A and control values (3.20 +/- 0.21 vs. 1.80 +/- 0.51 and 0.91 +/- 0.11, respectively; both P&lt;0.001).	Creatinine	42-52	beta-2-microglobulin	Homo sapiens	20-28
17406122-8	2007	Ischemia/reperfusion for 30 min induced a time-dependent reduction in Kir4.1 mRNA expression in parallel with plasma creatinine, however recovery was delayed after 60 min of ischemia, remaining reduced after 72 h of reperfusion when plasma creatinine was already normalized.	Creatinine	117-127	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	70-76
17098524-4	2006	The main outcome variable was the percentage change in creatinine clearance (CrCl), which was determined before surgery and at the most recent follow-up.	Creatinine	55-65	CRCL	Homo sapiens	77-81
11305804-7	2000	The TF levels were closely correlated with the thrombin antithrombin-III complex, a marker of thrombin activity in circulating blood, and with creatinine clearance (Ccr).	Creatinine	143-153	coagulation factor III, tissue factor	Homo sapiens	4-6
16895759-8	2006	The urinary COMP concentrations in AJD and SJD horses (1.02+/-0.75 and 1.55+/-1.17 microg/100mg creatinine, respectively) were significantly higher than normal (0.57+/-0.29 microg/100mg creatinine).	Creatinine	96-106	cartilage oligomeric matrix protein	Equus caballus	12-16
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP &gt; or =140 mmHg and/or DBP &gt; or =90 mmHg) was significantly (p &lt; 0.05) higher than that of the normotensive subjects (SBP &lt;140 mmHg and DBP &lt;90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	Creatinine	293-303	spermine binding protein	Rattus norvegicus	54-57
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP &gt; or =140 mmHg and/or DBP &gt; or =90 mmHg) was significantly (p &lt; 0.05) higher than that of the normotensive subjects (SBP &lt;140 mmHg and DBP &lt;90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	Creatinine	347-357	spermine binding protein	Rattus norvegicus	54-57
16895759-8	2006	The urinary COMP concentrations in AJD and SJD horses (1.02+/-0.75 and 1.55+/-1.17 microg/100mg creatinine, respectively) were significantly higher than normal (0.57+/-0.29 microg/100mg creatinine).	Creatinine	186-196	cartilage oligomeric matrix protein	Equus caballus	12-16
17112858-10	2006	Univariate analysis of values in kidney transplant recipients showed hepcidin to correlate significantly with total protein, ferritin, time after transplantation, creatinine, eGFR (simplified MDRD), cholesterol, neutrophil count, hsCRP, and IL-6.	Creatinine	163-173	hepcidin antimicrobial peptide	Homo sapiens	69-77
10731048-9	2000	In addition, the decreases in creatinine and lithium clearances induced by cisplatin were also attenuated by the NK1 receptor antagonist.	Creatinine	30-40	tachykinin receptor 1	Rattus norvegicus	113-125
10657375-7	2000	RESULTS: Cystatin C and creatinine correlated significantly (P = 0.001) with CrCl.	Creatinine	24-34	CRCL	Homo sapiens	77-81
11416233-2	2000	RESULTS: Multiple regression analysis indicated that among the various parameters examined, the level of leptin was positively associated with the body mass index and the levels of insulin, total cholesterol and uric acid, and was inversely associated with physical activity and the level of creatinine.	Creatinine	292-302	leptin	Homo sapiens	105-111
10594162-4	1999	beta(2) m levels correlated with indices of bone remodeling, as well as with serum creatinine and estradiol levels.	Creatinine	83-93	beta-2-microglobulin	Homo sapiens	0-9
10689899-10	1999	Multiple regression analysis showed that fat mass and serum creatinine were significant determinants of the leptin and leptin/fat mass values both in men and women, but that age was a significant determinant of these values only in men.	Creatinine	60-70	leptin	Homo sapiens	119-125
16984235-10	2006	Plasma creatinine levels were lower following IGF-I/IGFBP-3 complex (mean +/- SD, 56.2 +/- 16.8 micromol/l) vs placebo (61.5, 45.0, P &lt; 0.02).	Creatinine	7-17	insulin like growth factor binding protein 3	Homo sapiens	52-59
16971655-4	2006	Even more remarkable, eNOS(-/-) C57BLKS db/db exhibited decreases in GFR to levels &lt;50% of that in eNOS(+/+) C57BLKS db/db, as confirmed by increased serum creatinine.	Creatinine	159-169	nitric oxide synthase 3, endothelial cell	Mus musculus	22-26
16979743-6	2006	A positive correlation was found between serum PSA and creatinine (r = 0.053, P = 0.024).	Creatinine	55-65	kallikrein related peptidase 3	Homo sapiens	47-50
16979743-9	2006	Using the stepwise method, all other explanatory variables, except BMI, AST, and creatinine were eliminated (log10[PSA] = -0.124[BMI] + 0.063[creatinine] - 0.053[AST] + 0.097; r = 0.152, P &lt;0.001).	Creatinine	142-152	kallikrein related peptidase 3	Homo sapiens	115-118
16979743-10	2006	CONCLUSIONS: BMI, creatinine, and AST may influence the serum PSA level in this population.	Creatinine	18-28	kallikrein related peptidase 3	Homo sapiens	62-65
16910829-1	2006	Tenofovir disoproxil fumarate (TDF) is renally excreted by a combination of glomerular filtration and active tubular secretion, and its renal safety profiles have been reported based on a limited increase of serum creatinine (sCr) levels.	Creatinine	214-224	sex determining region Y	Homo sapiens	31-34
16403835-10	2006	Furthermore, SEW-2871, a selective S1P1 agonist, significantly decreased plasma creatinine in a dose-response manner with a maximal reduction of approximately 70% with a dose of 10 mg/kg.	Creatinine	80-90	sphingosine-1-phosphate receptor 1	Mus musculus	35-39
16249272-4	2006	Young male and female NHERF-1(-/-) mice demonstrated increased urinary excretion of phosphate and urine phosphate/creatinine ratios.	Creatinine	114-124	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	22-29
16249272-6	2006	Male and female NHERF-1 null mice also demonstrate increased urine calcium/creatinine and uric acid/creatinine ratios compared with wild-type controls.	Creatinine	75-85	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	16-23
16249272-6	2006	Male and female NHERF-1 null mice also demonstrate increased urine calcium/creatinine and uric acid/creatinine ratios compared with wild-type controls.	Creatinine	100-110	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	16-23
16878259-9	2006	RESULTS: The mean increase in serum creatinine in the 48 patients was 0.3 (0.18-0.41) mg/dL, due to a mean decrease of 25 (12.8-36.9) mL/min of creatinine clearance (CrCl).	Creatinine	36-46	CRCL	Homo sapiens	166-170
16524951-5	2006	In STZ-treated HO-2 (-/-) mice, there was marked renal functional impairment as reflected by an increase in plasma creatinine, associated with acute tubular damage and microvascular pathology as compared with HO-2 (+/+).	Creatinine	115-125	heme oxygenase 2	Mus musculus	15-19
16524951-7	2006	Upregulation of HO-1 in HO-2 (-/-) mice by weekly administration of cobalt protoporphyrin prevented the increase in plasma creatinine levels and tubulointerstitial and microvascular pathology.	Creatinine	123-133	heme oxygenase 2	Mus musculus	24-28
16541021-7	2006	A significant correlation existed between the basal urinary protein/Cr and the basal urinary MCP-1/Cr ratios.	Creatinine	68-70	C-C motif chemokine ligand 2	Homo sapiens	93-98
16541021-8	2006	PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment.	Creatinine	85-87	C-C motif chemokine ligand 2	Homo sapiens	151-156
16541021-8	2006	PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment.	Creatinine	85-87	C-C motif chemokine ligand 2	Homo sapiens	151-156
16481416-5	2006	Compared with the wild-type (WT) mice, CXCR3-deficient mice (CXCR3-/-) had significantly lower serum creatinine levels, better survival rate, and significantly less acute tubular necrosis and cellular infiltrates.	Creatinine	101-111	chemokine (C-X-C motif) receptor 3	Mus musculus	39-44
16761501-1	2006	The objective of this study was to compare the limit of agreement of creatinine clearance (CrCl) estimated by different equations with the CrCl measured by 24-hour urine collection in Hong Kong Chinese patients with systemic lupus erythematosus (SLE).	Creatinine	69-79	CRCL	Homo sapiens	91-95
16771251-5	2006	RESULTS: The decline in creatinine clearance in CTR animals from 0.38 +/- 0.03 to 0.28 +/- 0.03 mL/min/100 g (p &lt; 0.005), was prevented by EPO pretreatment (from 0.34 +/- 0.02 to 0.32 +/- 0.03 mL/min/100 g, NS).	Creatinine	24-34	calcitonin receptor	Rattus norvegicus	48-51
10589898-5	1999	The mean serum myoglobin level +/- SD was highest in cerebral malaria (457 +/- 246 vs. 170 +/- 150 and 209 +/- 125 ng/mL in uncomplicated and severe malaria, respectively; P &lt; .01) and correlated with the mean serum creatinine level (r = .39 for 36 patients; P = .02).	Creatinine	219-229	myoglobin	Homo sapiens	15-24
16771251-5	2006	RESULTS: The decline in creatinine clearance in CTR animals from 0.38 +/- 0.03 to 0.28 +/- 0.03 mL/min/100 g (p &lt; 0.005), was prevented by EPO pretreatment (from 0.34 +/- 0.02 to 0.32 +/- 0.03 mL/min/100 g, NS).	Creatinine	24-34	erythropoietin	Rattus norvegicus	142-145
16282887-5	2005	In children with polymorphic locus of the GSTP1 gene compared with children with homozygous wild alleles, increased urinary excretion of 3DCIF (P=0.029) and decreased creatinine clearance was found (Mann-Whitney P=0.03; median 81.1 mL/min/1.73 m vs. 105.0 mL/min/1.73 m, respectively).	Creatinine	167-177	glutathione S-transferase pi 1	Homo sapiens	42-47
16178870-6	2005	Female pSS patients with high IDO activity (kyn/trp x 1000 &gt; or = 34.0) had significantly higher ESR, serum C-reactive protein, serum IgA and serum beta-2 microglobulin concentrations as well as higher serum creatinine levels, and they had positive antinuclear antibodies more frequently and presented with more American-European consensus group criteria than those with low IDO activity (kyn/trp x 1000 &lt; 34.0).	Creatinine	211-221	indoleamine 2,3-dioxygenase 1	Homo sapiens	30-33
16030030-4	2005	METHODS: Patients were stratified by CKD stage using creatinine clearance (CrCl, ml/min) estimated by the modified MDRD equation using baseline core laboratory creatinine measures.	Creatinine	53-63	CRCL	Homo sapiens	75-79
16142851-1	2005	Low D-hormone syndrome, a disorder related to low creatinine clearance (CrCl), is associated with a roughly 4-fold increase in risk for falls.	Creatinine	50-60	CRCL	Homo sapiens	72-76
16245244-5	2005	RESULTS: Median urinary GSTP1-1 concentrations were significantly (p&lt;0.001) higher in women with preeclampsia [62.2 (4.3-291.2) ng/10 mmol Cr] compared to non-pregnant women with a history of preeclampsia [22.3 (0-142.6) ng/10 mmol Cr]).	Creatinine	142-144	glutathione S-transferase pi 1	Homo sapiens	24-31
10566220-10	1999	There was positive correlation of P-leptin with serum creatinine in non-dialysed women (r = 0.68, p &lt; 0.001) and a negative correlation with S-albumin in nephrotic men (r = -0.65, p &lt; 0.05).	Creatinine	54-64	leptin	Homo sapiens	36-42
10460890-6	1999	The urinary ratio of the concentrations of OPN and creatinine (OPN/Cre) in the urolithiasis patients (0.039 +/- 0.029) was significantly lower than that in the control subjects (0.062 +/- 0.030) (P&lt;0.05).	Creatinine	51-61	secreted phosphoprotein 1	Homo sapiens	63-66
15374073-5	1999	Among the general laboratory tests, there was only a significant correlation between M-CSF and serum creatinine; however, no significant correlation was found between M-CSF and other tests including blood cell counts.	Creatinine	101-111	colony stimulating factor 1	Homo sapiens	85-90
16245244-5	2005	RESULTS: Median urinary GSTP1-1 concentrations were significantly (p&lt;0.001) higher in women with preeclampsia [62.2 (4.3-291.2) ng/10 mmol Cr] compared to non-pregnant women with a history of preeclampsia [22.3 (0-142.6) ng/10 mmol Cr]).	Creatinine	235-237	glutathione S-transferase pi 1	Homo sapiens	24-31
16245244-6	2005	In addition, in normotensive pregnant women, urinary GSTP1-1 concentrations were significantly (p&lt;0.01) higher [82.6 (8.3-206.7) ng/10 mmol Cr]) compared to non-pregnant controls [5.1 (0-66.7) ng/10 mmol Cr].	Creatinine	143-145	glutathione S-transferase pi 1	Homo sapiens	53-60
16245244-6	2005	In addition, in normotensive pregnant women, urinary GSTP1-1 concentrations were significantly (p&lt;0.01) higher [82.6 (8.3-206.7) ng/10 mmol Cr]) compared to non-pregnant controls [5.1 (0-66.7) ng/10 mmol Cr].	Creatinine	207-209	glutathione S-transferase pi 1	Homo sapiens	53-60
15877794-8	2005	At 3-month post-transplantation, patients who had C(2) concentrations over 1500 ng/mL had higher serum creatinine as compared with those who had C(2) levels &lt;1300 ng/mL (2.23 +/- 0.8 vs. 1.44 +/- 0.38 mg/dL: p = 0.01).	Creatinine	103-113	complement C2	Homo sapiens	50-54
10232568-8	1999	Calculated donor CrCl &lt;100 ml/min was associated with higher recipient Cr levels at 1 year, 240+/-95 micromol/L vs. 180+/-54 micromol/L in recipients of kidneys from donors with CrCl levels &gt;100 ml/min (P&lt;.05).	Creatinine	17-19	CRCL	Homo sapiens	181-185
10232568-9	1999	The mean 1-year Cr level was 320+/-102 micromol/L in recipients with both a vascular score of 3/3 and a donor CrCl &lt;100 ml/min and 184+/-63 micromol/L in those with neither factor (P = .001).	Creatinine	16-18	CRCL	Homo sapiens	110-114
15877794-9	2005	Also, at 6-month post-transplantation, patients who had C(2) concentrations over 1300 ng/mL had higher serum creatinine (1.96 +/- 0.29 vs. 1.37 +/- 0.34 mg/dL: p &lt; 0.01) as compared with those who had C(2) levels &lt;1100 ng/mL.	Creatinine	109-119	complement C2	Homo sapiens	56-60
15896237-8	2005	Creatinine clearance (CrCl) was calculated using Cockroft and Gault and Brater equations.	Creatinine	0-10	CRCL	Homo sapiens	22-26
16357730-4	2005	RESULTS: The cutoff point of plasma creatinine &lt;2 showed 13% sensitivity and 100% specificity to detect CrCl &lt;50 mL/min.	Creatinine	36-46	CRCL	Homo sapiens	107-111
15259364-6	2004	Renal dysfunction was defined as urinary B2M &gt; 0.8 mg/g Cr (creatinine).	Creatinine	59-61	beta-2-microglobulin	Homo sapiens	41-44
15259364-6	2004	Renal dysfunction was defined as urinary B2M &gt; 0.8 mg/g Cr (creatinine).	Creatinine	63-73	beta-2-microglobulin	Homo sapiens	41-44
14656762-4	2004	We show that the urinary Ca/creatinine ratio is significantly decreased in Npt2-/-/1alphaOHase-/- mice compared with Npt2-/- mice.	Creatinine	28-38	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	75-79
14656762-6	2004	In Npt2-/- mice derived from dams fed a 1% Pi diet and maintained on the same diet, we observed a significant decrease in urinary Ca/creatinine that was also associated with 80% reduction in CV/TV when compared with counterparts fed a 0.6% diet.	Creatinine	133-143	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	3-7
15127324-9	2004	Cys C was positively correlated with beta2-microglobulin and creatinine and negatively with GFR values; beta2-microglobulin was also positively correlated with serum creatinine in microalbuminurics.	Creatinine	166-176	beta-2-microglobulin	Homo sapiens	104-123
15703088-1	2004	PURPOSE: We investigate the use of non-contrast helical computerized tomography (NCHCT) in the measurement of differential renal parenchymal volume as a surrogate for differential creatinine clearance (CrCl) for unilateral chronically obstructed kidney.	Creatinine	180-190	CRCL	Homo sapiens	202-206
14514727-6	2003	GATA-3 overexpression in T cells improved the 50% mortality incidence time for GATA-3-transgenic Yaa mice (41.6 wk), compared with Yaa mice (30.9 wk), and reduced proteinuria, serum creatinine levels, and the severity of glomerulonephritis in GATA-3-transgenic Yaa mice.	Creatinine	182-192	GATA binding protein 3	Mus musculus	0-6
14514736-5	2003	In group 1 (n = 13), urine MCP-1 excretion (136 +/- 14 pg/mg creatinine) was not different from normal volunteers (152 +/- 16 pg/mg); serum creatinine levels and urine total protein excretion were normal as well.	Creatinine	61-71	C-C motif chemokine ligand 2	Homo sapiens	27-32
14514736-6	2003	In group 2 (n = 27), urine MCP-1 excretion was increased (525 +/- 39 pg/mg creatinine), but serum creatinine levels and urine protein excretion were not different from normal.	Creatinine	75-85	C-C motif chemokine ligand 2	Homo sapiens	27-32
14974366-4	2003	beta 2- and alpha 2-microglobulin (beta 2-m and alpha 2-m), albumin (alb), immunoglobulin G (IgG), total protein (tp) and creatinine (cr) concentration were measured in the second time urine specimen in 66 renal allograft recipients.	Creatinine	22-24	alpha-2-macroglobulin	Homo sapiens	12-21
10682068-7	1999	Transperitoneal equilibration of creatinine concentration was faster in uremic animals: D/P at 4 hours was 0.94 +/- 0.06 during PET2 versus 0.77 +/- 0.08 during PET1, p &lt; 0.001.	Creatinine	33-43	FEV transcription factor, ETS family member	Rattus norvegicus	161-165
14733412-11	2003	The beta2-microglobulin increase was significant in the group with GFR 60-80 mL/min and of Cr in the group with GFR 40-60 mL/min.	Creatinine	91-93	beta-2-microglobulin	Homo sapiens	4-23
12941042-7	2003	alpha2-AP+/+ mice developed crescentic GN (38 +/- 9% glomeruli affected) with glomerular fibrin deposition and renal impairment (serum creatinine 30 +/- 1 micro mol L-1, normal without GN 11 +/- 1 micro mol L-1).	Creatinine	135-145	serine (or cysteine) peptidase inhibitor, clade F, member 2	Mus musculus	0-9
12882873-9	2003	Urinary MCP-1 levels decreased from 0.456 +/- 0.22 ng/mg creatinine to 0.08 +/- 0.096 ng/mg creatinine.	Creatinine	57-67	C-C motif chemokine ligand 2	Homo sapiens	8-13
12882873-9	2003	Urinary MCP-1 levels decreased from 0.456 +/- 0.22 ng/mg creatinine to 0.08 +/- 0.096 ng/mg creatinine.	Creatinine	92-102	C-C motif chemokine ligand 2	Homo sapiens	8-13
12694312-5	2003	Leptin is inversely related with plasma creatinine, suggesting that reduced renal clearance is a primary factor responsible for hyperleptinemia in ESRD.	Creatinine	40-50	leptin	Homo sapiens	0-6
10080403-5	1999	HGF significantly inhibited the tacrolimus-induced increase in the serum creatinine (SCr) level (P &lt; 0.05).	Creatinine	73-83	hepatocyte growth factor	Rattus norvegicus	0-3
9879598-4	1998	The purpose of the study was to estimate urine cathepsin B, collagenase activity and urine excretion of TGF-beta 1 and fibronectin in MG. Cathepsin B activity was greater in the urine of MG patients than in the control group (10.58 +/- 8.73 pmol AMC/mg creatinine per min-1 vs control 7.11 +/- 2.05 pmol AMC/mg creatinine per min-1; P &lt; 0.05).	Creatinine	311-321	cathepsin B	Homo sapiens	138-149
9844141-6	1998	METHODS: We determined urinary kallikrein activity [chromogenic substrate S2266 (D-val-leu-arg-paranitroanilide) assay; in microU/mg creatinine] in white (N = 15) and black (N = 11) ovulating females during the ovulatory cycle.	Creatinine	133-143	kallikrein related peptidase 4	Homo sapiens	31-41
9844141-10	1998	Urinary kallikrein activity increased from 623 +/- 86 microU/mg creatinine (mid-follicular) to 948 +/- 142 microU/mg creatinine (mid-luteal) in whites, but did not change in blacks during the ovulatory cycle [239 +/- 73 microU/mg creatinine (mid-follicular] to 244 +/- 41 microU/mg creatinine (mid-luteal)].	Creatinine	64-74	kallikrein related peptidase 4	Homo sapiens	8-18
9844141-10	1998	Urinary kallikrein activity increased from 623 +/- 86 microU/mg creatinine (mid-follicular) to 948 +/- 142 microU/mg creatinine (mid-luteal) in whites, but did not change in blacks during the ovulatory cycle [239 +/- 73 microU/mg creatinine (mid-follicular] to 244 +/- 41 microU/mg creatinine (mid-luteal)].	Creatinine	117-127	kallikrein related peptidase 4	Homo sapiens	8-18
9844141-10	1998	Urinary kallikrein activity increased from 623 +/- 86 microU/mg creatinine (mid-follicular) to 948 +/- 142 microU/mg creatinine (mid-luteal) in whites, but did not change in blacks during the ovulatory cycle [239 +/- 73 microU/mg creatinine (mid-follicular] to 244 +/- 41 microU/mg creatinine (mid-luteal)].	Creatinine	117-127	kallikrein related peptidase 4	Homo sapiens	8-18
9844141-10	1998	Urinary kallikrein activity increased from 623 +/- 86 microU/mg creatinine (mid-follicular) to 948 +/- 142 microU/mg creatinine (mid-luteal) in whites, but did not change in blacks during the ovulatory cycle [239 +/- 73 microU/mg creatinine (mid-follicular] to 244 +/- 41 microU/mg creatinine (mid-luteal)].	Creatinine	117-127	kallikrein related peptidase 4	Homo sapiens	8-18
12803507-5	2003	Urinary MCP-1 excretion levels in non-DN, DN, IgAN groups were 157.2 (52.8-378.5), 346.1 (147.0-1276.7), and 274.4 (162.2-994.5) ng/g creatinine, median (range), respectively.	Creatinine	134-144	C-C motif chemokine ligand 2	Homo sapiens	8-13
14692126-4	2003	PURPOSE: The aim of this study was to compare the serum levels of low molecular weight proteins CyC and beta 2-microglobulin (beta 2-MG) with creatinine clearance, as well known measure of GFR, in renal transplant patients and control group of patients with different renal disease.	Creatinine	142-152	beta-2-microglobulin	Homo sapiens	126-135
14692126-10	2003	RESULTS: In renal transplant patients as well as in control group of patients the significant correlation between creatinine clearance and reciprocal values of the serum CyC (rt = 0.828; pt &lt; 0.001; rc = 0.603; pc &lt; 0.05) and reciprocal values of the serum beta 2-MG levels (rt = 0.791; pt &lt; 0.001; rc = 0.627; pc &lt; 0.05) was found (Graph 1).	Creatinine	114-124	beta-2-microglobulin	Homo sapiens	263-272
12709468-8	2003	In vivo human: correlation of plasma creatinine and soluble Fas ligand.	Creatinine	37-47	Fas ligand	Homo sapiens	60-70
12709468-12	2003	There was a significant correlation between changes in soluble Fas ligand and changes in creatinine in patients with ARDS (R = 0.64, P =.002).	Creatinine	89-99	Fas ligand	Homo sapiens	63-73
12559283-4	2003	RESULTS: The univariate logistic regression analysis indicated that high or low age, body weight, body mass index, creatinine, and creatinine clearance were significant factors in relation to serum PSA concentration compared with the reference group.	Creatinine	115-125	kallikrein related peptidase 3	Homo sapiens	198-201
12559283-4	2003	RESULTS: The univariate logistic regression analysis indicated that high or low age, body weight, body mass index, creatinine, and creatinine clearance were significant factors in relation to serum PSA concentration compared with the reference group.	Creatinine	131-141	kallikrein related peptidase 3	Homo sapiens	198-201
12460051-1	2002	BACKGROUND: The National Kidney Foundation-Dialysis Outcome Quality Initiative (NKF-DOQI) recommends a weekly creatinine clearance (CrCl) of 60 L/wk/1.73 m2 or greater and a Kt/V of 2.0 or greater as peritoneal dialysis (PD) adequacy standards.	Creatinine	110-120	CRCL	Homo sapiens	132-136
12427158-9	2002	RESULTS: Values of urinary AQP2 at 0, 1, 2, 3, and 4 hours after oral water loading for RIA, IB, and ELISA were, respectively (fmol/mg creatinine): 0 h: 266 +/- 28, 405 +/- 74, 294 +/- 41; 1 h: 159 +/- 59, 267 +/- 147, 195 +/- 95; 2 h: 48 +/- 17, 19 +/- 10, 38 +/- 18; 3 h: 79 +/- 18, 70 +/- 24, 80 +/- 15; 4 h: 147 +/- 21, 161 +/- 31, 136 +/- 15.	Creatinine	135-145	aquaporin 2	Homo sapiens	27-31
12209742-11	2002	Multivariable modeling demonstrated an independent association of the OPN level with alkaline phosphatase, hemoglobin, and creatinine levels.	Creatinine	123-133	secreted phosphoprotein 1	Homo sapiens	70-73
12138282-7	2002	The carriage rate of IL1RN*2 was significantly higher in IgAN patients with severe proteinuria (&gt;or=1.6 g/day) or increased serum creatinine level (&gt;or=2.0 mg/dl; p &lt; 0.05).	Creatinine	133-143	interleukin 1 receptor antagonist	Homo sapiens	21-26
12194021-4	2002	Both serum Ca and urine Ca/creatinine were significantly decreased in Npt2(-/-) mice after an overnight fast and were no longer different from that in wild-type mice.	Creatinine	27-37	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	70-74
9753036-4	1998	In untreated CRF patients and healthy controls, serum SCF levels were significantly correlated with blood urea nitrogen (BUN), creatinine.	Creatinine	127-137	KIT ligand	Homo sapiens	54-57
9753036-6	1998	In untreated CRF patients, serum SCF levels were significantly correlated with BUN, creatinine, and sKIT.	Creatinine	84-94	KIT ligand	Homo sapiens	33-36
12130981-11	2002	Increased natriuresis/diuresis did not significantly differ between the atrial natriuretic peptide and the furosemide group, whereas creatinine clearance in the atrial natriuretic peptide group was significantly higher than that in the furosemide group.	Creatinine	133-143	natriuretic peptide A	Canis lupus familiaris	161-187
9876290-4	1998	The antidiuretic effect of Ang-(1-7) was associated with an increase in urinary Na+ concentration, an increase in urinary osmolality and a reduction in creatinine clearance (CCr: 0.65 +/- 0.04 ml/min vs 1.45 +/- 0.18 ml/min in vehicle-treated rats, P &lt; 0.05).	Creatinine	152-162	angiogenin	Rattus norvegicus	27-35
9767622-3	1998	Positive correlations were found between serum creatinine and serum CYFRA 21-1 and ProGRP levels.	Creatinine	47-57	gastrin releasing peptide	Homo sapiens	83-89
9706839-4	1998	In the subjects with CRF, the clearance of cyclic GMP was reduced in proportion to the clearance of creatinine, but there was no significant difference in the fractional excretion of cyclic GMP (median group values: 78.1% in the normal group, 78.9% in the hypertensive group and 70.2% in the CRF group).	Creatinine	100-110	5'-nucleotidase, cytosolic II	Homo sapiens	50-53
9590367-9	1998	Urinary RBP but not AER was an excellent predictor of diabetic nephropathy as defined by serum creatinine (P = 0.0001).	Creatinine	95-105	retinol binding protein 4	Homo sapiens	8-11
9579608-8	1998	Both CD8+ lymphocytes and HLA-DR+ T cells, found at month + 1 post-Tx, were negatively correlated with the concentration of creatinine along the follow-up.	Creatinine	124-134	CD8a molecule	Homo sapiens	5-8
12042261-7	2002	There was more variation in pregnanediol:creatinine in the normal-ovary infertile and PCO groups than in the fertile controls.	Creatinine	41-51	PCOS1	Homo sapiens	86-89
9614399-7	1998	The mean intraindividual biological variation of cadmium and RBP, expressed as creatinine corrected, was 18% and 40% respectively in the subjects exposed to cadmium.	Creatinine	79-89	retinol binding protein 4	Homo sapiens	61-64
9640077-3	1997	Urinary level of type IV collagen was significantly elevated in subjects with IDDM and albuminuria as compared to IDDM without microalbuminuria and healthy subjects of cathepsin B was significantly higher in diabetic patients with albuminuria as compared to patients without microalbuminuria and healthy subjects (0.82 +/- 0.53 vs. 0.25 +/- 0.17 vs. 0.22 +/- 0.05 mlU/mg creatinine, p &lt; 0.01).	Creatinine	371-381	cathepsin B	Homo sapiens	168-179
9370186-6	1997	Results showed a significant reduction of proteinuria in the IL-1ra-treated mice, compared with saline-treated mice (urinary albumin/creatinine, 0.24 +/- 0.04 v 0.39 +/- 0.03, P &lt; 0.001).	Creatinine	133-143	interleukin 1 receptor antagonist	Mus musculus	61-67
9367006-3	1997	RBP:creatinine ratios were significantly higher in non-renal SLE patients compared with female controls (P = 0.002).	Creatinine	4-14	retinol binding protein 4	Homo sapiens	0-3
18653110-1	1997	The present study was conducted to evaluate accuracy of a recently proposed method for estimating creatinine clearance (CLcr, ml/min) from actual body weight (ABW, kg), serum creatinine (Scr, micromol/l), and serum albumin (Alb, g/l) in elderly patients with muscle atrophy (the debilitated elderly).	Creatinine	98-108	chymotrypsin C	Homo sapiens	120-124
9108987-6	1997	Any change in creatinine clearance (CLCR) should result in a proportional correction of the dosage regimen.	Creatinine	14-24	chymotrypsin C	Homo sapiens	36-40
9056112-7	1997	Data, expressed as Median and Interquartile Range, are 388/209-626 micrograms THP/mmol creatinine for C (n = 85) and 124/82-171 micrograms THP/mmol creatinine for L (n = 23).	Creatinine	87-97	uromodulin	Homo sapiens	78-81
12042261-9	2002	In summary, there was greater variability in luteal phase pregnanediol:creatinine ratios in the PCO and infertile normal-ovary groups than in women with normal ovaries and proven fertility.	Creatinine	71-81	PCOS1	Homo sapiens	96-99
11889157-4	2002	After adjustment for fat mass and creatinine clearance, correlations between leptin and bone alkaline phosphatase (positive) and OC (negative) disappeared but, remained significant with urine C-telopeptide of type I collagen (r = -0.27, P &lt; 0.01).	Creatinine	34-44	leptin	Homo sapiens	77-83
12043267-8	2002	Minimal diuresis was higher, creatinine and urea levels lower in patients on rIL-2 (647.0 +/- 268.6 mg/day vs 422.0 +/- 198.2 ml/day, p &lt; 0.05; 221.8 +/- 98.1 mcmol/l vs 398.9 +/- 234.9 mcmol/l, p &lt; 0.05; 14.9 +/- 5.1 mcmol/l vs 22.0 +/- 9.0 mmol/l, p &lt; 0.05).	Creatinine	29-39	interleukin 2	Rattus norvegicus	77-82
11725162-6	2001	The concentrations of hUII-LI in urine from normal individuals were 7.4 +/- 0.9 microg/g creatinine, whereas its plasma concentration was undetectable (&lt; 50 pg/ml).	Creatinine	89-99	urotensin 2	Homo sapiens	22-26
11711350-13	2001	The relationship of the creatinine level to PSA recurrence was not significant in the univariate or multivariable analysis.	Creatinine	24-34	kallikrein related peptidase 3	Homo sapiens	44-47
9048347-2	1997	However, standardized accurate GFR methodology is expensive and cumbersome; therefore, estimates of GFR based on serum creatinine concentration have been employed.	Creatinine	119-129	Rap guanine nucleotide exchange factor 5	Homo sapiens	100-103
9048347-3	1997	The purpose of the study presented here was to assess the accuracy and precision of using serum creatinine measurements to estimate GFR in the screen cohort of The African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study.	Creatinine	96-106	Rap guanine nucleotide exchange factor 5	Homo sapiens	132-135
9048347-4	1997	GFR was estimated by four methods: 100/serum creatinine, Cockcroft-Gault equation, creatinine clearance from 24-h urine collection, and a new regression equation derived from the pilot study data.	Creatinine	45-55	Rap guanine nucleotide exchange factor 5	Homo sapiens	0-3
9048347-4	1997	GFR was estimated by four methods: 100/serum creatinine, Cockcroft-Gault equation, creatinine clearance from 24-h urine collection, and a new regression equation derived from the pilot study data.	Creatinine	83-93	Rap guanine nucleotide exchange factor 5	Homo sapiens	0-3
8995741-11	1997	We present a statistical description of serial serum creatinine measurements in NPH1.	Creatinine	53-63	nephrocystin 1	Homo sapiens	80-84
8819047-4	1996	In normal dogs, the median urine bFGF concentration was 2.23 ng/g creatinine (quartile range, 1.53 to 5.12 ng/g creatinine).	Creatinine	66-76	fibroblast growth factor 2	Canis lupus familiaris	33-37
8819047-7	1996	The median urine bFGF concentration in dogs with transitional cell carcinoma was 9.86 ng/g creatinine (quartile range, 7.40 to 21.63 ng/g creatinine).	Creatinine	91-101	fibroblast growth factor 2	Canis lupus familiaris	17-21
8819047-7	1996	The median urine bFGF concentration in dogs with transitional cell carcinoma was 9.86 ng/g creatinine (quartile range, 7.40 to 21.63 ng/g creatinine).	Creatinine	138-148	fibroblast growth factor 2	Canis lupus familiaris	17-21
8672021-8	1996	Serum pro-gastrin-releasing peptide concentrations were also elevated in patients with chronic glomerulonephritis or diabetes mellitus when their serum creatinine concentrations were greater than 120 micromol/l.	Creatinine	152-162	gastrin releasing peptide	Homo sapiens	10-35
8956297-7	1996	In the PDGF-A-positive patients, total urinary protein (TUP), urinary beta2-microglobulin (u-beta2-m) and systolic and diastolic blood pressure were significantly higher, and creatinine clearance (Ccr) was significantly lower than in the PDGF-A-negative patients.	Creatinine	175-185	platelet derived growth factor subunit A	Homo sapiens	7-13
8956297-8	1996	In the PDGF-B-positive patients, TUP, serum creatinine (s-Cr) and urinary and serum beta2-m increased significantly and Ccr decreased significantly.	Creatinine	44-54	platelet derived growth factor subunit B	Homo sapiens	7-13
8883035-2	1996	Reduction in creatinine clearance and elevation in fractional excretion of sodium in mice receiving cisplatin was ameliorated by ulinastatin administration.	Creatinine	13-23	alpha 1 microglobulin/bikunin precursor	Mus musculus	129-140
8720036-4	1995	(2) ANP infusion significantly increased urine flow rate (UFR), creatinine clearance (CCr), fractional excretion rates of sodium (FENa) and chloride (FECl), and urinary phosphorus and magnesium (Mg) excretions in a dose-dependent manner without affecting renal plasma flow and fractional excretion rates of potassium and urea in cisplatin-treated rats.	Creatinine	64-74	natriuretic peptide A	Rattus norvegicus	4-7
8808225-3	1995	The creatinine clearance (Clc) as a determinant of the GFR may overestimate GFR caused by the tubular secretion of creatinine.	Creatinine	4-14	Rap guanine nucleotide exchange factor 5	Homo sapiens	55-58
8808225-3	1995	The creatinine clearance (Clc) as a determinant of the GFR may overestimate GFR caused by the tubular secretion of creatinine.	Creatinine	4-14	Rap guanine nucleotide exchange factor 5	Homo sapiens	76-79
8808225-3	1995	The creatinine clearance (Clc) as a determinant of the GFR may overestimate GFR caused by the tubular secretion of creatinine.	Creatinine	115-125	Rap guanine nucleotide exchange factor 5	Homo sapiens	55-58
8808225-3	1995	The creatinine clearance (Clc) as a determinant of the GFR may overestimate GFR caused by the tubular secretion of creatinine.	Creatinine	115-125	Rap guanine nucleotide exchange factor 5	Homo sapiens	76-79
8808225-13	1995	The overestimation of GFR by creatinine (Clc-Cli) decreased during DI-1 from 1.35 +/- 1.69 ml/min to 0.26 +/- 0.60 (P &lt; 0.05) and during DI-2 from 1.01 +/- 1.33 ml/min to 0.10 +/- 0.67 (P &lt; 0.01).	Creatinine	29-39	Rap guanine nucleotide exchange factor 5	Homo sapiens	22-25
7887831-8	1994	However, experimental values of bTr for creatinine were lower than predicted values.	Creatinine	40-50	G protein-coupled receptor 148	Homo sapiens	32-35
11771868-11	2001	S-creatinine at biopsy was highest when tubular vimentin staining was strongest, and tubular vimentin staining was strongest in patients with acute tubular damage.	Creatinine	2-12	vimentin	Homo sapiens	48-56
11472452-14	2001	Clinical cut-offs of &lt; 4.5 and &lt; 5.2 mg/mmol creatinine for males and females, respectively, are suggested for the interpretation of changes in ACR in random urine samples in young people with Type 1 diabetes.	Creatinine	51-61	acrosin	Homo sapiens	150-153
11499557-9	2001	CONCLUSIONS: With declining renal function, serum beta2M increases more and before than serum Cr.	Creatinine	94-96	beta-2-microglobulin	Homo sapiens	50-56
11269791-1	2001	BACKGROUND: Little is known about when the urinary excretion of a combination of N-acetyl-beta-D-glucosaminidase (NAG) and beta2-microglobulin (beta2MG) concentration [relative to creatinine (Cr)] reaches maximal values during uncomplicated normotensive pregnancy.	Creatinine	180-190	beta-2-microglobulin	Homo sapiens	144-151
11269791-1	2001	BACKGROUND: Little is known about when the urinary excretion of a combination of N-acetyl-beta-D-glucosaminidase (NAG) and beta2-microglobulin (beta2MG) concentration [relative to creatinine (Cr)] reaches maximal values during uncomplicated normotensive pregnancy.	Creatinine	192-194	beta-2-microglobulin	Homo sapiens	144-151
11157380-5	2001	Compared with normal controls (n = 20), mean +/- SD of urinary OPN in IgAN patients was decreased significantly (21.4 +/- 6.2 versus 11.6 +/- 9.6 mg/g creatinine, P: &lt; 0.001).	Creatinine	151-161	secreted phosphoprotein 1	Homo sapiens	63-66
11310345-1	2001	Considerable sample to sample variability in deoxypyridinoline crosslink/creatinine (Dpd/CREAT) ratio values was confirmed when twice-weekly sampling for 77 days was performed in C57 mice.	Creatinine	73-83	dihydropyrimidine dehydrogenase	Mus musculus	85-88
7912541-8	1994	In FSGS, gamma-GT excretion correlated with the following: BUN (r = 0.48), serum creatinine (r = -0.66), serum protein (r = -0.54), serum albumin (r = -0.68) and serum cholesterol (r = 0.87).	Creatinine	81-91	inactive glutathione hydrolase 2	Homo sapiens	9-17
8096976-0	1993	Creatinine clearance with cimetidine for measurement of GFR.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	56-59
1580447-11	1992	In the steroid-unresponsive group, the likelihood ratios for urinary RBP greater than 4000 micrograms/g creatinine and for B2M greater than 3000 micrograms/g creatinine were 3.8 and 3.0, respectively.	Creatinine	104-114	retinol binding protein 4	Homo sapiens	69-72
1580447-12	1992	The probability was 100% that values of RBP of less than 1300 micrograms/g creatinine and B2M of less than 130 micrograms/g creatinine were from steroid-responsive patients.	Creatinine	75-85	retinol binding protein 4	Homo sapiens	40-43
1610983-8	1992	There was a significant linear relationship (P less than 0.005, r = 0.38) between calculated creatinine clearance and renal oxygen consumption with a y intercept representing basal renal oxygen consumption (115 mumol of O2/min/kidney) and a slope of 2.3 mumol of O2/mL.	Creatinine	93-103	immunoglobulin kappa variable 1D-39	Homo sapiens	263-268
1436286-3	1992	We also found a significant correlation of plasma levels of C3a with plasma creatinine.	Creatinine	76-86	complement C3	Homo sapiens	60-63
1794250-6	1991	(5) CD 4/CD 8 was negatively correlated with the serum creatinine level (r = -0.524).	Creatinine	55-65	CD8a molecule	Homo sapiens	9-13
11250367-0	2001	Correlation between the glomerular filtratiion rate (GFR), serum creatinine (SCR), creatinine clearance (CRCL) and the calculated creatinine clearance (CALC CRCL) in heart transplant (HTX) patients (PTS).	Creatinine	83-93	CRCL	Homo sapiens	105-109
11250367-0	2001	Correlation between the glomerular filtratiion rate (GFR), serum creatinine (SCR), creatinine clearance (CRCL) and the calculated creatinine clearance (CALC CRCL) in heart transplant (HTX) patients (PTS).	Creatinine	83-93	CRCL	Homo sapiens	105-109
11050699-8	2000	The Desmin-LMWDS clearance was directly correlated to the creatinine clearance (r = 0.8244, n = 18, p &lt; 0.001).	Creatinine	58-68	desmin	Homo sapiens	4-10
1790129-3	1991	There was a good correlation between serum RBP and creatinine (r = 0.80, n = 96, p less than 0.001) and, on logarithmic scale, between serum RBP and Ccr(r = 0.77, n = 80, P less than 0.001).	Creatinine	51-61	retinol binding protein 4	Homo sapiens	43-46
1674166-7	1991	However if correcting gamma-GTP activity by creatinine, even a spot urine sample may be used for clinical use.	Creatinine	44-54	inactive glutathione hydrolase 2	Homo sapiens	22-31
1977540-2	1990	In NIDDM subjects the excretions of TP, Alb, NAG, AAP, GGT (expressed in relation to creatinine) were significantly higher and were abnormal in 59.9%, 68.8%, 47.2%, 41.4% and 13.4% of the subjects, respectively.	Creatinine	85-95	inactive glutathione hydrolase 2	Homo sapiens	55-58
11041571-2	2000	However, we describe a myeloma patient with renal failure (serum creatinine 4.2 mg/dl, creatinine clearance 11.2 ml/min) receiving CPA 2 g/m2 for 2 days, who developed unexpectedly severe toxicity, including myopericarditis and prolonged myelosuppression.	Creatinine	87-97	carboxypeptidase A2	Homo sapiens	131-136
10893335-4	2000	Urinary aquaporin-2 concentrations after AVP infusion were higher in controls (611.8+/-105.6 fmol/mg creatinine) than in IDDM (462.0+/-94.9 fmol/mg creatinine, P = 0.	Creatinine	101-111	aquaporin 2	Homo sapiens	8-19
10893335-4	2000	Urinary aquaporin-2 concentrations after AVP infusion were higher in controls (611.8+/-105.6 fmol/mg creatinine) than in IDDM (462.0+/-94.9 fmol/mg creatinine, P = 0.	Creatinine	148-158	aquaporin 2	Homo sapiens	8-19
10886576-6	2000	In the latter subgroup, fetal serum beta2m was significantly and positively correlated (r2 = 0.91) with postnatal serum creatinine.	Creatinine	120-130	beta-2-microglobulin	Homo sapiens	36-42
10886576-8	2000	Four of 6 survivors with a postnatal serum creatinine&gt; 50 micromol/L had a fetal serum beta2m greater than 5 mg/L.	Creatinine	43-53	beta-2-microglobulin	Homo sapiens	90-96
10886576-9	2000	CONCLUSION: Fetal serum beta2-microglobulin is a marker for renal function and predicts postnatal serum creatinine in bilateral or low fetal obstructive uropathy.	Creatinine	104-114	beta-2-microglobulin	Homo sapiens	24-43
10918946-3	2000	There was a significant correlation between TM and serum creatinine levels.	Creatinine	57-67	thrombomodulin	Homo sapiens	44-46
10849526-12	2000	Mild and transient non-hematological toxicity (hemorrhagic cystitis, decrease in serum creatinine clearance and CNS dysfunction) was seen most frequently in the IFO+GM-CSF group.	Creatinine	87-97	colony stimulating factor 2	Homo sapiens	165-171
2376943-7	1990	An at least transitory increase in creatinine levels as a side effect of CS-A was observed in all patients.	Creatinine	35-45	chorionic somatomammotropin hormone 1	Homo sapiens	73-77
33790859-7	2021	Results of the Spearman correlation analysis showed that the GDF-15 levels were positively associated with the duration of diabetes morbidity, fasting plasma glucose, systolic blood pressure, albumin/creatinine ratio, creatinine, and liver enzymes, but negatively associated with eGFR (both P < 0.001).	Creatinine	200-210	growth differentiation factor 15	Homo sapiens	61-67
33790859-7	2021	Results of the Spearman correlation analysis showed that the GDF-15 levels were positively associated with the duration of diabetes morbidity, fasting plasma glucose, systolic blood pressure, albumin/creatinine ratio, creatinine, and liver enzymes, but negatively associated with eGFR (both P < 0.001).	Creatinine	218-228	growth differentiation factor 15	Homo sapiens	61-67
10830304-5	2000	Both Npt2-/- and Npt2+/+ mice exhibit a significant rise in the urinary cAMP/creatinine ratio in response to PTH, indicating that generalized resistance to PTH cannot account for the absence of the PTH response in Npt2-/- mice.	Creatinine	77-87	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	5-9
10830304-5	2000	Both Npt2-/- and Npt2+/+ mice exhibit a significant rise in the urinary cAMP/creatinine ratio in response to PTH, indicating that generalized resistance to PTH cannot account for the absence of the PTH response in Npt2-/- mice.	Creatinine	77-87	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	17-21
10830304-5	2000	Both Npt2-/- and Npt2+/+ mice exhibit a significant rise in the urinary cAMP/creatinine ratio in response to PTH, indicating that generalized resistance to PTH cannot account for the absence of the PTH response in Npt2-/- mice.	Creatinine	77-87	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	17-21
11379474-1	2000	Predictability of creatinine clearance (CrCl) from serum creatinine would reduce the cost of renal care and obviate the need for 24-hours urine collection.	Creatinine	18-28	CRCL	Homo sapiens	40-44
11379474-1	2000	Predictability of creatinine clearance (CrCl) from serum creatinine would reduce the cost of renal care and obviate the need for 24-hours urine collection.	Creatinine	57-67	CRCL	Homo sapiens	40-44
11045271-4	2000	Adding one hour of cycler therapy increases Kt/V and creatinine clearance (CrCl) by approximately 6.4%-8%.	Creatinine	53-63	CRCL	Homo sapiens	75-79
26628795-9	2015	In conclusion, we suggest that urine NGAL with cut-off point of 22.5 ng/ml has acceptable sensitivity and specificity for early diagnosis of CIN in patients with normal serum creatinine, but regarding NPV and PPV the best performance of this value is to rule out the CIN in patients at risk who received contrast media.	Creatinine	175-185	lipocalin 2	Homo sapiens	37-41
10901625-4	2000	Fasting tHcy and PML-tHcy correlated with fasting proinsulin (r = 0.395, p &lt; 0.05; r = 0.386, p&lt; 0.05) and creatinine (r = 0.489, p &lt; 0.01; r = 0.339, p &lt; 0.05), resp.	Creatinine	113-123	PML nuclear body scaffold	Homo sapiens	17-20
10961356-2	2000	Therefore, the aim of our study was to investigate leptin and TNF alpha levels and their association with blood pressure, sex steroids, insulin, creatinine and lipids in type 2 diabetic patients.	Creatinine	145-155	leptin	Homo sapiens	51-57
10689899-10	1999	Multiple regression analysis showed that fat mass and serum creatinine were significant determinants of the leptin and leptin/fat mass values both in men and women, but that age was a significant determinant of these values only in men.	Creatinine	60-70	leptin	Homo sapiens	108-114
10370741-7	1999	The urinary excretion of dipeptidase (U/mmol creatinine) showed significant inverse correlations with that of beta 2-microglobulin, albumin and alpha 1-microglobulin, and with serum concentrations of creatinine, beta 2-microglobulin and alpha 1-microglobulin.	Creatinine	45-55	beta-2-microglobulin	Homo sapiens	110-130
10370741-7	1999	The urinary excretion of dipeptidase (U/mmol creatinine) showed significant inverse correlations with that of beta 2-microglobulin, albumin and alpha 1-microglobulin, and with serum concentrations of creatinine, beta 2-microglobulin and alpha 1-microglobulin.	Creatinine	45-55	beta-2-microglobulin	Homo sapiens	212-232
9887080-6	1999	Reduction of type I IP3R also occurred in parallel with renal hypertrophy, increased creatinine clearance, and increased renal TGF-beta1 expression in the diabetic rats.	Creatinine	85-95	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	20-24
34874540-10	2022	In multivariable regression analysis, higher CSF NfL Z-score was statistically significantly associated with older age and higher CSF protein, and higher plasma NfL Z-score with older age, higher serum creatinine and lower bodyweight.	Creatinine	202-212	neurofilament light chain	Homo sapiens	49-52
33567936-9	2021	Higher GDF15 concentrations were significantly associated with decreased eGFR and increased urine protein-to-creatinine ratio (uPCR).	Creatinine	109-119	growth differentiation factor 15	Homo sapiens	7-12
34826089-5	2022	The median urinary concentrations of 4-OH-BP, BP-3, BP-1, and BP-8 in the 1st trimester were 6.62, 7.5, 4.39, and 1.32 microg/g creatinine and those in the 3rd trimester were 3.15, 16.98, 9.95, and 1.04 microg/g creatinine, respectively.	Creatinine	128-138	BP8	Homo sapiens	62-66
34800169-9	2022	RESULTS: Age-adjusted linear regression analyses revealed increased plasma NfL concentrations with increasing creatinine (beta = 0.01, p < 0.001) and Q-albumin (beta = 0.07, p = 0.008).	Creatinine	110-120	neurofilament light chain	Homo sapiens	75-78
34800169-13	2022	However, plasma NfL was also influenced by other factors, such as damage accrual, creatinine, and Q-albumin, thereby obscuring the interpretation of how plasma NfL reflects CNS involvement.	Creatinine	82-92	neurofilament light chain	Homo sapiens	16-19
34830657-9	2021	NGAL was shown to be more accurate in predicting AKI development than creatinine; furthermore, NGAL levels were associated with an increased risk of AKI development (1.005 (1.002-1.008), p < 0.0001).	Creatinine	70-80	lipocalin 2	Homo sapiens	95-99
34829262-6	2021	The optimal model was the one-compartment model with first-order administration and first-order elimination incorporating creatinine clearance (CLcr) as a covariate of clearance and body weight as a covariate of distribution volume.	Creatinine	122-132	chymotrypsin C	Homo sapiens	144-148
34680152-6	2021	H4R-/- mice showed a lower urine 24 h outflow, and albumin-to-creatinine ratio (ACR) compared to wild-type mice.	Creatinine	62-72	histamine receptor H4	Mus musculus	0-3
34692424-4	2021	The mean value of AFM1 and FB1 was 4.3 pg/mg creatinine from 76 samples (72 %), and 50 pg/mg creatinine from 75 samples (71 %), respectively.	Creatinine	45-55	TCF3 fusion partner	Homo sapiens	27-30
34575364-6	2021	The urinary concentrations of cathepsin B normalized with the urinary concentrations of creatinine (cathepsin B/Cr.)	Creatinine	88-98	cathepsin B	Homo sapiens	30-41
34575364-6	2021	The urinary concentrations of cathepsin B normalized with the urinary concentrations of creatinine (cathepsin B/Cr.)	Creatinine	88-98	cathepsin B	Homo sapiens	100-111
34594322-8	2021	Results: IgAN patients with more than 50% crescent formation showed higher complement activation levels than the other patients (urinary C3a/creatinine (C3a/Cr): 6.7295 ng/mg, interquartile range (IQR) 1.4652-62.1086 ng/mg vs. 0.1055 ng/mg, IQR 0-1.4089 ng/mg; urinary C5a/Cr: 15.6202 ng/mg, 4.3127-66.7347 ng/mg vs. 0.3280 ng/mg, IQR 0.0859-2.4439 ng/mg; urinary sC5b-9/Cr: 98.6357 ng/mg, 8.8058-1,087.4578 ng/mg vs. 1.4262 ng/mg, 0.0916-11.0858 ng/mg, all p-values <0.001).	Creatinine	141-151	complement C3	Homo sapiens	153-156
34245977-9	2021	Dok3-/- mice showed lower creatinine levels and NGAL expression, and increased survival rates compared to 129S mice.	Creatinine	26-36	docking protein 3	Mus musculus	0-4
34440375-3	2021	The GAMT knockout (KO) mouse model presents biochemical alterations in bodily fluids, the brain, and muscles, including increased GAA and decreased Cr and creatinine (Crn) levels, which are similar to those observed in humans.	Creatinine	155-165	guanidinoacetate methyltransferase	Mus musculus	4-8
34440375-3	2021	The GAMT knockout (KO) mouse model presents biochemical alterations in bodily fluids, the brain, and muscles, including increased GAA and decreased Cr and creatinine (Crn) levels, which are similar to those observed in humans.	Creatinine	167-170	guanidinoacetate methyltransferase	Mus musculus	4-8
34177800-10	2021	The level of plasma RBP4 was positively correlated with plasma uric acid, creatinine, fasting insulin, IR index, total cholesterol and triglyceride levels in patients with HUA.	Creatinine	74-84	retinol binding protein 4	Homo sapiens	20-24
34754473-9	2021	The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP mug/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.	Creatinine	235-245	glutathione S-transferase theta 1	Homo sapiens	145-150
34764788-10	2021	We found a positive correlation between Gd-IgA1 and creatinine (r = 0.34), and negative between Gd-IgA1 and GFR (r = -0.35) at the end of follow-up.	Creatinine	52-62	immunoglobulin heavy constant alpha 1	Homo sapiens	43-47
35380292-9	2022	RESULTS: Serum creatinine, urea nitrogen and glucose, and PPARgamma and GLUT1 expression in rat PF model were reduced by PPARgamma agonists Rosiglitazone or 15d-PGJ2 and elevated by antagonist GW9662.	Creatinine	15-25	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	121-130
35419185-9	2022	Compared with before treatment, after 3 months of intervention, the levels of serum uric acid, urine microalbumin/creatinine, urine NGAL/creatinine, and urine KIM-1/creatinine were significantly decreased in the febuxostat group (P < 0.05), while the changes of blood urea nitrogen, serum creatinine, and epidermal growth factor receptor (eGFR) were not statistically significant (P > 0.05).	Creatinine	165-175	hepatitis A virus cellular receptor 1	Homo sapiens	159-164
35419185-11	2022	After 3 months of intervention, compared with the control group, the serum uric acid, microalbumin/creatinine, urine NGAL/creatinine, and urine KIM-1/creatinine were significantly decreased in the febuxostat group (P < 0.05), but there was no significant difference in blood urea nitrogen, creatinine, and eGFR (P > 0.05).	Creatinine	150-160	hepatitis A virus cellular receptor 1	Homo sapiens	144-149
35453583-7	2022	There were significant differences between studied patients and normal controls, as follows: serum CA125 (130.91 vs. 19.75 U/mL, p = 0.004); urinary CA125-creatinine ratio (5.591 vs. 0.254 ng/mg, p = 0.028); and urinary VDBP-creatinine ratio (28.028 vs. 7.301 ng/mg, p = 0.018).	Creatinine	155-165	mucin 16, cell surface associated	Homo sapiens	149-154
35346864-5	2022	Importantly, SLC7A5 expression in T and B cells was positively correlated with blood urea nitrogen and serum creatinine.	Creatinine	109-119	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	13-19
34989167-12	2022	Independent predictors of admission CA-125 were higher BNP and lower creatinine.	Creatinine	69-79	mucin 16, cell surface associated	Homo sapiens	36-42
35051728-10	2022	Creatinine and pre-dialysis urea were negatively correlated with IL-10 for the entire follow-up.	Creatinine	0-10	interleukin 10	Homo sapiens	65-70
35148702-10	2022	IGFBP-4 also correlated positively with creatinine level and negatively with eGFR, in people with DN supporting its involvement in DN.	Creatinine	40-50	insulin like growth factor binding protein 4	Homo sapiens	0-7
35179743-11	2022	Besides, body mass index (BMI) value, gestational age, systolic blood pressure, and serum creatinine level in preeclampsia patients with the genotype GG of rs101201 in the promoter region of MMP-9 gene were not statistically significantly different from those in Control group (p>0.05).	Creatinine	90-100	matrix metallopeptidase 9	Homo sapiens	191-196
35032832-13	2022	Interestingly, only the group that received cASC-H showed a reduction in glucose and creatinine levels although it did not reach statistical significance.All DN-induced groups treated with ASC reduced significantly renal lesions such as mesangial expansion, mesangiolysis, microaneurysms and acute tubular necrosis compared to ND-induced placebo group (p <= 0.05).	Creatinine	85-95	PYD and CARD domain containing	Rattus norvegicus	189-192
35090502-9	2022	RESULT: In vivo, NQO1 overexpression reduced the urinary albumin/creatinine ratio (UACR) and blood urea nitrogen (BUN) level in db/db mice.	Creatinine	65-75	NAD(P)H dehydrogenase, quinone 1	Mus musculus	17-21
9782673-9	1998	Factor 2, which was mainly composed of isoflavonoids, was positively associated with creatinine and uric acid levels.	Creatinine	85-95	transcription termination factor 2	Homo sapiens	0-8
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	90-100	POU class 2 homeobox 2	Homo sapiens	107-111
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	90-100	solute carrier family 47 member 1	Homo sapiens	116-121
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	102-104	POU class 2 homeobox 2	Homo sapiens	107-111
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	102-104	solute carrier family 47 member 1	Homo sapiens	116-121
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	164-166	POU class 2 homeobox 2	Homo sapiens	107-111
35163972-6	2022	Pearson correlation analysis was used to analyze the correlation between transporters and Creatinine (Cr), OCT2 and MATE1 showed a strong negative correlation with Cr.	Creatinine	164-166	solute carrier family 47 member 1	Homo sapiens	116-121
35291613-7	2022	Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations.	Creatinine	108-118	interleukin 17A	Homo sapiens	74-79
35291613-10	2022	The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy.	Creatinine	99-109	interleukin 17A	Homo sapiens	37-42
9649574-6	1998	We show that OP-1 preserves kidney function, as determined by reduced blood urea nitrogen and serum creatinine, and increased survival rate when administered 10 min before or 1 or 16 h after ischemia, and then at 24-h intervals up to 72 h after reperfusion.	Creatinine	100-110	bone morphogenetic protein 7	Homo sapiens	13-17
9700478-5	1998	Plasma levels of adrenomedullin positively correlated with various parameters, including serum creatinine levels, urinary excretion of protein, and systolic blood pressure.	Creatinine	95-105	adrenomedullin	Homo sapiens	17-31
9619532-6	1998	It was found that LHbeta cf is the predominant LH associated molecular form in the urine during peri-ovulatory period, peaking 1-3 days later than intact LH and reaching a concentration of approximately 600 fmol/mg creatinine, 7-fold higher than either LH or LH free beta subunit.	Creatinine	215-225	luteinizing hormone subunit beta	Homo sapiens	18-24
9562260-9	1998	In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status.	Creatinine	35-45	methylenetetrahydrofolate reductase	Homo sapiens	173-178
9574459-10	1998	Multivariate analysis of longitudinal data showed that recipients" serum creatinine was positively correlated (p &lt; 0.001) with urine AAP and negatively correlated with urine albumin, with diuresis volume and urine creatinine (p &lt; 0.01).	Creatinine	73-83	serpin family F member 2	Homo sapiens	136-139
9067930-11	1997	VLDL-R mRNA levels in the heart and skeletal muscle were directly related to creatinine clearance and inversely related to serum triglyceride and VLDL concentrations.	Creatinine	77-87	very low density lipoprotein receptor	Rattus norvegicus	0-6
9086282-15	1997	The ICAM-1 monoclonal antibody, ICAM-Ab, provided some renal protection against ischemia-reperfusion injury in this study as measured by serum creatinine, BUN and renal histopathology.	Creatinine	143-153	intercellular adhesion molecule 1	Rattus norvegicus	4-10
23889114-4	1997	BP 7,10 8,9 tetrol was detected in 20 of 43 47 patients, ranging from 1 not detected to 124 fmol mumol-1 creatinine.	Creatinine	105-115	BP7	Homo sapiens	0-4
9012555-5	1997	Although there are a variety of methods for evaluating the various aspects of renal function, the most practical and commonly used clinical measure of renal function is estimated creatinine clearance (CLCR) as a marker for glomerular filtration.	Creatinine	179-189	chymotrypsin C	Homo sapiens	201-205
35592808-13	2022	Creatinine decreased between period 1 and both period 2 and period 3 (P < 0.001) and between period 2 and period 3 (P < 0.001).	Creatinine	0-10	period circadian regulator 2	Homo sapiens	47-55
2619121-9	1989	Significance of the EP and PTH association was reduced when analyzed, using a multiple linear regression analysis that included serum creatinine values.	Creatinine	134-144	erythropoietin	Canis lupus familiaris	20-22
2619121-9	1989	Significance of the EP and PTH association was reduced when analyzed, using a multiple linear regression analysis that included serum creatinine values.	Creatinine	134-144	parathyroid hormone	Canis lupus familiaris	27-30
2789921-2	1989	Glomerular filtration rate is commonly assessed by measurement of endogenous creatinine clearance (CLcr).	Creatinine	77-87	chymotrypsin C	Homo sapiens	99-103
2917593-2	1989	Pirenzepine renal clearance, total clearance and terminal (dominant) half-life were found to be correlated with the creatinine clearance (CLCR), but this was not the case for the volume of distribution and the nonrenal clearance.	Creatinine	116-126	chymotrypsin C	Homo sapiens	138-142
9144032-4	1997	In patients on dietary treatment a positive correlation was found between plasma F1 + 2 and serum creatinine.	Creatinine	98-108	coagulation factor XII	Homo sapiens	81-87
8989240-12	1997	Plasma adrenomedullin concentrations were increased in patients with renal impairment (14.1 +/- 0.9 pmol/L) compared to those in healthy volunteers (8.1 +/- 0.7 pmol/L), with a good correlation (r = 0.86) between circulating adrenomedullin and plasma creatinine.	Creatinine	251-261	adrenomedullin	Homo sapiens	7-21
9027780-5	1997	RESULTS: In patients with a serum creatinine &lt; or = 110 mumol/l, 81.94% +/- 6.5 of parathyroid cells expressed vitamin D receptor.	Creatinine	34-44	vitamin D receptor	Homo sapiens	114-132
3172517-4	1988	With regard to the toxicity, the NAG index (NAG activity/urinary creatinine) rose markedly in all patients, but toxicity was almost similar to that seen from a systemic administration.	Creatinine	65-75	NBAS subunit of NRZ tethering complex	Homo sapiens	33-36
3391004-5	1988	Because of the reciprocal relationship of AUC and clearance, AUC did not change to any appreciable extent until creatinine clearance (CLCR) dropped to about 50 ml/min.	Creatinine	112-122	chymotrypsin C	Homo sapiens	134-138
3391004-9	1988	In patients with moderately compromised renal function (glomerular filtration rate less than 40 ml/min), tubular secretion rate of creatinine approaches its glomerular filtration rate and hence CLCR could be used as a predictor of renal clearance and other disposition parameters.	Creatinine	131-141	chymotrypsin C	Homo sapiens	194-198
3394526-5	1988	There was a trend for an association between elevated NAGs and reduced creatinine clearance (P less than .08), but no association was found between concentrating ability and either elevated NAG or reduced creatinine clearance.	Creatinine	71-81	N-acetylglutamate synthase	Homo sapiens	54-58
9274837-9	1997	Creatinine clearance overestimated GFR in IgAN.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	35-38
9394432-9	1997	Based on 42 patients with different degree of impaired renal function, a significant correlation of nANP and serum creatinine was found.	Creatinine	115-125	N-acetylneuraminic acid phosphatase	Homo sapiens	100-104
3343514-10	1988	Analysis of urine samples from 118 normal male volunteers showed, firstly, that urinary creatinine measurement was a good indicator of the amount of urine which could be safely introduced in the assay without risk of non-specific interference by other organic compounds and, secondly, that the desmosine/creatinine ratio was a reliable index for an in vivo assessment of degraded elastin excretion.	Creatinine	88-98	elastin	Rattus norvegicus	380-387
3696332-6	1987	Its curvilinear relation to the reciprocal of serum creatinine indicated a proportional decline of GFR and tubular function or the accumulation of inhibitors of the proximal tubular anion secretory pathway.	Creatinine	52-62	Rap guanine nucleotide exchange factor 5	Homo sapiens	99-102
3492959-3	1986	All clearances (total, renal, and nonrenal) and urinary recoveries of unchanged drug were found to be linearly related to creatinine clearance (CLCR).	Creatinine	122-132	chymotrypsin C	Homo sapiens	144-148
3530532-4	1986	A control population of 118 male subjects gave a geometric mean urinary RBP concentration of 7.7 micrograms per millimole of creatinine and a 95th centile of 22 micrograms per millimole of creatinine.	Creatinine	125-135	retinol binding protein 4	Homo sapiens	72-75
3530532-6	1986	Of the 117 subjects exposed to cadmium fumes, 103 gave both RBP and beta 2-microglobulin concentrations on the same side of the upper 95th centile values of 22 and 38 micrograms per millimole of creatinine for RBP and beta 2-microglobulin respectively (Chi-square analysis p less than 0.001), demonstrating that RBP and beta 2-microglobulin detect tubular proteinuria with equal sensitivity and specificity.	Creatinine	195-205	retinol binding protein 4	Homo sapiens	210-213
3530532-6	1986	Of the 117 subjects exposed to cadmium fumes, 103 gave both RBP and beta 2-microglobulin concentrations on the same side of the upper 95th centile values of 22 and 38 micrograms per millimole of creatinine for RBP and beta 2-microglobulin respectively (Chi-square analysis p less than 0.001), demonstrating that RBP and beta 2-microglobulin detect tubular proteinuria with equal sensitivity and specificity.	Creatinine	195-205	retinol binding protein 4	Homo sapiens	210-213
2941371-4	1986	This fall in renin secretion was associated with significant increases (p less than 0.05) in creatinine clearance, urine flow, sodium excretion, and the filtered load of sodium.	Creatinine	93-103	renin	Canis lupus familiaris	13-18
3904082-2	1985	The relationship observed in neutral urine was: RBP (micrograms/mmol creatinine) = 0.786 + 0.814 beta 2-m (micrograms/mmol creatinine).	Creatinine	69-79	retinol binding protein 4	Homo sapiens	48-51
3904082-2	1985	The relationship observed in neutral urine was: RBP (micrograms/mmol creatinine) = 0.786 + 0.814 beta 2-m (micrograms/mmol creatinine).	Creatinine	123-133	retinol binding protein 4	Homo sapiens	48-51
8918684-8	1996	Cortisol/creatinine rations in urine were significantly higher when voided after insulin administeration, compared to when voided after saline treatment.	Creatinine	9-19	insulin	Canis lupus familiaris	81-88
3926348-6	1985	The 2.5-97.5 centile interval for RBP in urine is from less than 0.5 to 12.2 micrograms per millimole of creatinine (median 5.8).	Creatinine	105-115	retinol binding protein 4	Homo sapiens	34-37
6533397-1	1984	A significant negative correlation (P less than 0.0001) exists between the mean blood pressure (MBP) and the rate of decline in creatinine clearance with time in years (BCr) in 446 subjects in the Baltimore Longitudinal Study on Aging (BLSA) followed serially on five or more visits over a period of 8 or more years.	Creatinine	128-138	BCR activator of RhoGEF and GTPase	Homo sapiens	169-172
8918684-9	1996	Insulin-induced increments in cortisol/ creatinine ratios were nonsignificant when urine samples were assayed after dichloromethane extraction.	Creatinine	40-50	insulin	Canis lupus familiaris	0-7
8675358-1	1996	The expression (Estimated-Predicted)/Predicted creatinine generation ?(E-P)/P?	Creatinine	47-57	ferrochelatase	Homo sapiens	71-77
6390875-0	1984	B2-microglobulin and renal graft rejection: relationship to plasma creatinine during stable transplant function and graft rejection.	Creatinine	67-77	major histocompatibility complex, class I, G	Homo sapiens	0-16
8571387-3	1996	Measurements taken 72 h after drug treatment indicated that compared to animals receiving cisplatin only, ANP co-treated rats had lower post-treatment plasma creatinine concentrations (0.70 +/- 0.07 vs 1.3 +/- 0.17 mg/dl; P &lt; 0.05), blood urea nitrogen (BUN) concentrations (44.2 +/- 5.8 vs. 65.5 +/- 2.1 mg/dl; P &lt; 0.05) and higher post-treatment glomerular filtration rates (GFR) (0.71 +/- 0.18 vs. 0.14 +/- 0.03 ml/min; P &lt; 0.05).	Creatinine	158-168	natriuretic peptide A	Rattus norvegicus	106-109
6487505-5	1984	Because of the high variability of pharmacokinetic parameters, patients with PBC treated with CS-A need to be regularly controlled for nephrotoxicity by estimation of serum creatinine and bioavailability (trough blood levels).	Creatinine	173-183	chorionic somatomammotropin hormone 1	Homo sapiens	94-98
6130197-2	1983	Fasting urinary hydroxyproline/creatinine and calcium/creatinine ratios declined in the Cl2MDP group but not in the placebo group.	Creatinine	54-64	endogenous retrovirus group W member 5	Homo sapiens	88-91
6167115-3	1981	In 3 patients with slightly elevated serum creatinine, some tendency towards an elevation of vitamin A and RBP levels was seen.	Creatinine	43-53	retinol binding protein 4	Homo sapiens	107-110
8591870-5	1996	Plasma adrenomedullin concentrations were positively correlated with serum creatinine levels and inversely correlated with glomerular filtration rates in the hypertensive patients, whereas adrenomedullin values were not correlated with blood pressure level, left ventricular mass index, or left ventricular ejection fraction.	Creatinine	75-85	adrenomedullin	Homo sapiens	7-21
990383-1	1976	The serum concentrations of Zn-alpha 2-glycoprotein (ZnaGP) were found to be increased in renal patients with both normal and restricted function; in the latter they showed significant correlation with serum creatinine and urea levels and a decrease after haemodialysis.	Creatinine	208-218	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	28-51
990383-1	1976	The serum concentrations of Zn-alpha 2-glycoprotein (ZnaGP) were found to be increased in renal patients with both normal and restricted function; in the latter they showed significant correlation with serum creatinine and urea levels and a decrease after haemodialysis.	Creatinine	208-218	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	53-58
8832301-3	1996	Initial U-Hg excretion varied between 60 and 2360 micrograms/g creatinine.	Creatinine	63-73	small nucleolar RNA host gene 1	Homo sapiens	8-12
952282-6	1976	Urinary kallikrein concentration was significantly lower in black children than in white children (p less than 0.001) and was positively correlated with urinary creatinine and urinary potassium and inversely related to urinary sodium concentrations.	Creatinine	161-171	kallikrein related peptidase 4	Homo sapiens	8-18
944115-2	1976	Serum RBP was increased in chronic renal diseases when the serum creatinine increased.	Creatinine	65-75	retinol binding protein 4	Homo sapiens	6-9
1245602-6	1976	P113 also reduced the clearance of para-aminohippurate, creatinine, sodium, and potassium, a pattern similar to that induced by A II.	Creatinine	56-66	signal transducer and activator of transcription 2	Homo sapiens	0-4
951347-3	1976	The association of DIP to 4 other fundamental histological varieties of diseases of the pulmonary interstitium (UIP, BIP, LIP, GIP) is at the origin of Liebow"s classification.	Creatinine	19-22	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	122-125
1193311-7	1975	There were also significant correlations with serum creatinine, blood urea nitrogen, and PSP (r = 0.6, 0.63, and -0.62, respectively).	Creatinine	52-62	microseminoprotein beta	Homo sapiens	89-92
33202067-7	2021	Creatinine clearance (ClCr ) and CSF-lactate were detected as significant covariates, showing that the total vancomycin plasma clearance (Cl) depends on ClCr and furthermore, the clearance (Cldif ) between the central and CSF compartment correlates with CSF lactate concentration.	Creatinine	0-10	chymotrypsin C	Homo sapiens	22-26
33576089-7	2021	RESULTS: In the univariate analysis, circulating chemerin levels were positively associated with body-mass index (BMI), waist circumference, waist-to-hip ratio (WHR), systolic (SBP) and diastolic blood pressure (DBP), hemoglobin A1C (HbA1C), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), creatinine, uric acid, alanine aminotransferase (ALT), gamma-glutamyl transferase (gamma-GT), leukocyte and platelet counts both in men and women, and negatively associated with high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR) and total bilirubin.	Creatinine	320-330	retinoic acid receptor responder 2	Homo sapiens	49-57
7637259-7	1995	In contrast, animals treated with the IL-1ra over this period showed stabilization of glomerular injury (protein-uria; P &lt; 0.001) and a recovery of normal renal function (creatinine clearance; P &lt; 0.05).	Creatinine	174-184	interleukin 1 receptor antagonist	Rattus norvegicus	38-44
7962564-5	1994	Renal failure patients with plasma creatinine of 1.5-3, 3-6, and &gt; 6 mg/dl had higher plasma adrenomedullin levels than healthy subjects by 78% (P &lt; 0.05), 131% (P &lt; 0.001), and 214% (P &lt; 0.001), respectively.	Creatinine	35-45	adrenomedullin	Homo sapiens	96-110
7940804-1	1994	In clinical practice p-creatinine is used to estimate changes of GFR.	Creatinine	23-33	Rap guanine nucleotide exchange factor 5	Homo sapiens	65-68
7985687-2	1994	Creatinine clearance (CLcr) was estimated by applying the Cockcroft-Gault equation using total body weight (TBW), ideal body weight (IBW), and dosage weight (DW) and with Salazar-Corcoran equations using fat-free body mass (FBM) in 100 obese and 100 nonobese patients.	Creatinine	0-10	chymotrypsin C	Homo sapiens	22-26
7904759-3	1994	Plasma creatinine measured (mg/dl) 24 hr after 30 min of ischemia was 0.61 +/- 0.05 in the anti-ICAM-1-treated animals compared with 2.4 +/- 0.14 (P &lt; 0.0001) in the vehicle-treated ischemic group.	Creatinine	7-17	intercellular adhesion molecule 1	Rattus norvegicus	96-102
33758009-11	2021	Proteinuria and plasma creatinine strongly associated with plasma cholesterol, PCSK9, and HS changes.	Creatinine	23-33	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	79-84
7904759-4	1994	Forty-eight hours after ischemia, creatinine values were 0.46 +/- 0.05 and 2.03 +/- 0.22 (P &lt; 0.0001) in anti-ICAM-1 and vehicle-treated groups, respectively.	Creatinine	34-44	intercellular adhesion molecule 1	Rattus norvegicus	113-119
8304478-2	1994	Compared with rats administered vehicle, rats administered 20 micrograms HGF subcutaneously 30 min postischemia had significantly lower serum creatinine and blood urea nitrogen levels over the course of 7 days postocclusion, enhanced insulin clearances measured on day 2 postocclusion, reduced mortality, and much less injury evident by examination of kidney histologies 7 days postinjury.	Creatinine	142-152	hepatocyte growth factor	Rattus norvegicus	73-76
8242106-6	1993	All CRF and CRF-F animals increased their levels of serum creatinine (CRF = 1.81 +/- 0.05; CRF-F = 1.75 +/- 0.05; SHAM = 0.72 +/- 0.09 mg/dL p &lt; 0.001).	Creatinine	58-68	corticotropin releasing hormone receptor 1	Rattus norvegicus	70-77
1395904-2	1992	Since fingernail creatinine (Ncr) reflects serum creatinine (Scr) at the time of nail formation, it has been suggested that Ncr level might represent that of Scr around 4 months previously.	Creatinine	17-27	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	29-32
1758535-5	1991	In particular, the serum THGP levels were more reduced according to the decrease in the clearance values of endogenous creatinine (CCR).	Creatinine	119-129	uromodulin	Homo sapiens	25-29
1679961-5	1991	Enzyme activities of alanine-aminopeptidase (AAP), gamma-glutamyltransferase (GGT), beta-n-acetylglucosaminidase (NAG), kallikrein with creatinine as point of reference were kinetically measured in 4 urine samples (1 before c.m.	Creatinine	136-146	kallikrein related peptidase 4	Homo sapiens	120-130
1698438-5	1990	Coefficients of log-transformed data with creatinine-derived glomerular filtration rate (GFR) were -0.87 for B2M, -0.71 for RBP, and -0.62 for A1M.	Creatinine	42-52	retinol binding protein 4	Homo sapiens	124-127
2357454-1	1990	A significant reduction of kallikrein activity in urine (assayed by its amidolytic activity) was found in 64 normotensive workers who had been exposed to cadmium for 11 years on average and whose cadmium concentrations in urine ranged from 2.2 to 33.1 micrograms/g creatinine.	Creatinine	265-275	kallikrein related peptidase 4	Homo sapiens	27-37
34039051-11	2021	Increasing severity of creatinine rise and oliguria confers increasing risk-adjusted mortality, especially for admissions with low PIM3 risk of death.	Creatinine	23-33	Pim-3 proto-oncogene, serine/threonine kinase	Homo sapiens	131-135
33432415-6	2021	NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 +- 143.9 and 139.4 +- 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 +- 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 +- 44.96 ng/g creatinine.	Creatinine	126-136	lipocalin 2	Homo sapiens	0-4
33432415-6	2021	NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 +- 143.9 and 139.4 +- 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 +- 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 +- 44.96 ng/g creatinine.	Creatinine	213-223	lipocalin 2	Homo sapiens	0-4
33432415-6	2021	NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 +- 143.9 and 139.4 +- 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 +- 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 +- 44.96 ng/g creatinine.	Creatinine	213-223	lipocalin 2	Homo sapiens	0-4
34027124-7	2021	BDNF showed a negative correlation with bilirubin (R = -0.35, p = 0.005) and international normalized ratio (INR) (R = -0.37, p = 0.003), and positive with platelets (PLT) (R = 0.36, p = 0.004), while no associations with age, sex, body mass index (BMI), waist-hip ratio (WHR), creatinine and ammonia were noted.	Creatinine	278-288	brain derived neurotrophic factor	Homo sapiens	0-4
2357454-2	1990	The mean (geometric) urinary kallikrein activity (in U/g creatinine) amounted to 0.52 (range 0.11-1.90) in the control group (n = 193) against 0.39 (range 0.10-1.03) in the cadmium group, and the prevalence of abnormally low activity levels (less than or equal to 0.20 U/g creatinine) amounted to 17.2% in the cadmium group against 5.2% in the control group.	Creatinine	57-67	kallikrein related peptidase 4	Homo sapiens	29-39
2180310-8	1990	C6D rabbits had a greater rise in serum creatinine at 120 hours (2.3 +/- 0.5 mg/dl vs. 1.3 +/- 6.4, P = 0.132).	Creatinine	40-50	LOW QUALITY PROTEIN: complement component C6	Oryctolagus cuniculus	0-3
34900255-9	2022	The change in rate of TRACP-5b levels were positively associated with changes in P, Cr-estimated glomerular filtration rate and TRACP-5b levels at the start of TAF.	Creatinine	84-86	acid phosphatase 5, tartrate resistant	Homo sapiens	22-30
34898058-11	2022	In patients with serum WNT4 above the median value, serum creatinine was higher.	Creatinine	58-68	Wnt family member 4	Homo sapiens	23-27
34907118-5	2022	RESULTS: HBP was significantly higher in patients with sepsis and was positively correlated to PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin and lactate.	Creatinine	164-174	azurocidin 1	Homo sapiens	9-12
34876020-7	2021	Furthermore, patients with high density of glomerular IgM and low levels of CFH had heavier proteinuria, higher serum creatinine and lower plasma C3 levels (5.7 +- 3.1 g/d vs. 4.7 +- 3.5 g/d, P = 0.037; 150.1 +- 121.0 mumol/L vs. 105.6 +- 97.1 mumol/L, P = 0.005; 0.3 +- 0.2 mug/L vs. 0.4 +- 0.2 mug/L, P = 0.04, respectively), comparing with those with low density of glomerular IgM and low levels of CFH.	Creatinine	118-128	complement factor H	Homo sapiens	76-79
34779262-9	2021	Klotho overexpression attenuated the increases in blood pressure, serum blood urea nitrogen level, and serum creatinine level in aging mice.	Creatinine	109-119	klotho	Mus musculus	0-6
34637945-7	2021	Average 3-MGA among all carriers was 39.66 mmol/mol of creatinine.	Creatinine	55-65	MAX dimerization protein MGA	Homo sapiens	10-13
34846174-4	2021	When sex-adjusted log urine pentosidine-to-creatinine ratio stratified by smile frequency grade were compared using analysis of covariance, urine pentosidine-to-creatinine ratio was significantly decreased according to the increase in smile frequency.	Creatinine	43-53	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	74-79
34846174-4	2021	When sex-adjusted log urine pentosidine-to-creatinine ratio stratified by smile frequency grade were compared using analysis of covariance, urine pentosidine-to-creatinine ratio was significantly decreased according to the increase in smile frequency.	Creatinine	43-53	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	235-240
34846174-4	2021	When sex-adjusted log urine pentosidine-to-creatinine ratio stratified by smile frequency grade were compared using analysis of covariance, urine pentosidine-to-creatinine ratio was significantly decreased according to the increase in smile frequency.	Creatinine	161-171	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	74-79
34846174-4	2021	When sex-adjusted log urine pentosidine-to-creatinine ratio stratified by smile frequency grade were compared using analysis of covariance, urine pentosidine-to-creatinine ratio was significantly decreased according to the increase in smile frequency.	Creatinine	161-171	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	235-240
34944613-7	2021	Cd treatment significantly increased urea nitrogen and creatinine levels, along with tp53, Bax, Nos2 and Il1b mRNA, while reduced that of Bcl2, as well as glutathione (GSH) content and glutathione peroxidase (GPx) activity.	Creatinine	55-65	cathepsin D	Mus musculus	0-2
34840044-13	2021	CPB flow did not affect survival rate, hospital stay, intensive care unit stay, or serum lactate in post-operative day 1, but serum creatinine (mg/dL) level increased transiently in patients with low pump flow group(0.9 +- 0.4 vs 1.3 +- 0.7,p < 0.05).	Creatinine	132-142	carboxypeptidase B1	Homo sapiens	0-3
34479967-6	2021	We show that miR-23b-/- mice develop an IgAN-like phenotype of mesangial IgA and C3 deposition associated with development of albuminuria, hypertension, an elevated serum creatinine, and dysregulated mucosal IgA synthesis.	Creatinine	171-181	microRNA 23b	Mus musculus	13-20
34650691-10	2021	Moreover, kidney/body weight ratio, urea, creatinine, and urine protein were increased, and the weight and endogenous creatinine clearance rate decreased in the DKD group and the normal chemerin group (all P<0.05).	Creatinine	42-52	retinoic acid receptor responder 2	Rattus norvegicus	186-194
34650691-10	2021	Moreover, kidney/body weight ratio, urea, creatinine, and urine protein were increased, and the weight and endogenous creatinine clearance rate decreased in the DKD group and the normal chemerin group (all P<0.05).	Creatinine	118-128	retinoic acid receptor responder 2	Rattus norvegicus	186-194
34491152-8	2021	Creatinine and urea were adjusted, TGF-beta/Smad signaling was suppressed causing down-regulation to microRNA-21.	Creatinine	0-10	transforming growth factor alpha	Rattus norvegicus	35-43
32944826-1	2021	BACKGROUND: Characterizing the dynamics of serum creatinine concentrations (Scr) and associated creatinine clearance (CLcr) as a measure of kidney function in extremely low birth weight (<= 1000 g; ELBW) neonates remains challenging.	Creatinine	96-106	chymotrypsin C	Homo sapiens	118-122
34278465-5	2021	The results demonstrated that BTK was activated in the kidneys of patients with DN and was associated with the progression of proteinuria, creatinine levels, estimated glomerular filtration rate and pathological changes in the kidneys of patients with DN.	Creatinine	139-149	Bruton tyrosine kinase	Homo sapiens	30-33
33669495-7	2021	However urinary netrin-1 normalized by urinary concentration of creatinine were IA-547.9 (360.2-687.5) ng/mg cr., IB-163.64 (119.15-295.96) ng/mg cr., and II-81.37 (56.84-138.58) ng/mg cr., respectively and differ significantly between the examined groups (p = 0.00).	Creatinine	64-74	netrin 1	Homo sapiens	16-24
33669495-8	2021	The netrin-1/creatinine ratio is increased in premature babies.	Creatinine	13-23	netrin 1	Homo sapiens	4-12
34302189-9	2021	After adjusting for age, creatinine, and treatment at discharge, patients with bio-ADM plasma concentrations above the median (> 44.6 pg/mL) derived disproportional benefit if treated with diuretics (interaction p values < 0.001).	Creatinine	25-35	adrenomedullin	Homo sapiens	83-86
34173962-6	2022	We fitted logistic regression models adjusted for sex, age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), creatinine, and C-reactive protein (CRP) to associate bio-ADM plasma levels to mortality, hospitalization, intravenous (IV) diuretic treatment and HF diagnosis.	Creatinine	115-125	adrenomedullin	Homo sapiens	173-176
34173962-9	2022	Bio-ADM (per interquartile range from median) predicts both 90-day mortality (odds ratio (OR): 1.5, 95% confidence interval (CI) 1.2-2.0, p < 0.002) and hospitalization (OR: 1.5, 95% CI 1.2-1.8, p < 0.001) independently of sex, age, NT-proBNP, creatinine, and CRP.	Creatinine	244-254	adrenomedullin	Homo sapiens	4-7
34248948-7	2021	In addition, the inhibitors against Syk and PAD4 attenuated lupus characteristics (serum creatinine, proteinuria, and anti-dsDNA) in Fcgr2b-/- mice at 120 h post-renal I/R injury.	Creatinine	89-99	spleen tyrosine kinase	Mus musculus	36-39
34517507-5	2021	Using equations developed over the last decades, creatinine clearance (CLCr) is readily estimated taking into account patients" biological sex, age, body composition, and sometimes race.	Creatinine	49-59	chymotrypsin C	Homo sapiens	71-75
33515095-5	2021	HBP was significantly higher in patients classified as having sepsis and was negatively associated with the oxygenation ratio and positively associated with creatinine and lactate.	Creatinine	157-167	azurocidin 1	Homo sapiens	0-3
34071541-6	2021	GATM risk allele carriers in the dialysis-independent group may have a genetic susceptibility to higher creatinine production rather than increased serum creatinine due to kidney malfunction, and therefore, do not progress to dialysis-dependent kidney failure.	Creatinine	104-114	glycine amidinotransferase	Homo sapiens	0-4
34071541-6	2021	GATM risk allele carriers in the dialysis-independent group may have a genetic susceptibility to higher creatinine production rather than increased serum creatinine due to kidney malfunction, and therefore, do not progress to dialysis-dependent kidney failure.	Creatinine	154-164	glycine amidinotransferase	Homo sapiens	0-4
34729216-5	2021	Results: The median concentration of urinary KIM-1 normalized to urinary creatinine was lower in patients with RCC compared to UC (1.35 vs 1.86 ng/mg creatinine, p = 0.04).	Creatinine	73-83	hepatitis A virus cellular receptor 1	Homo sapiens	45-50
34729216-5	2021	Results: The median concentration of urinary KIM-1 normalized to urinary creatinine was lower in patients with RCC compared to UC (1.35 vs 1.86 ng/mg creatinine, p = 0.04).	Creatinine	150-160	hepatitis A virus cellular receptor 1	Homo sapiens	45-50
34792000-9	2021	RESULTS: The Ang-(1-7) attenuated the increase of the plasmatic creatinine and proteinuria caused by GM but did not change the glomerular filtration rate nor tubular necrosis.	Creatinine	64-74	angiogenin	Rattus norvegicus	13-21
35616755-7	2022	RESULTS: Among the 76 proliferative LN cases, the number of CD68 macrophage infiltrates was positively correlated with serum creatinine (SCr) level, the proportion of glomeruli sclerosis and focal segmental sclerosis, tubulointerstitial inflammation, and chronicity indices, while negatively correlated with the glomerular filtration rate.	Creatinine	125-135	CD68 molecule	Homo sapiens	60-64
35420493-7	2022	Plasma TBP concentrations decreased over 8 to 12 h in cohorts 1 to 4, and apparent total body clearance (CL/F) correlated (R2 = 0.585) with creatinine clearance (CLCR).	Creatinine	140-150	TATA-box binding protein	Homo sapiens	7-10
35228297-3	2022	METHODS: We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,315 individuals of European ancestry from 13 cohorts.	Creatinine	104-114	uromodulin	Homo sapiens	140-150
35094884-7	2022	RESULTS: Urinary RBP4/creatinine was inversely correlated with allograft function (r = -0.54, P < .001 with eGFR, and r = 0.49, P < .001 with serum creatinine, respectively).	Creatinine	22-32	retinol binding protein 4	Homo sapiens	17-21
33584144-5	2021	Results: The URBP level (expressed by the RBP/creatinine ratio) was higher in the NAFLD patients compared with the non-NAFLD patients.	Creatinine	46-56	retinol binding protein 4	Homo sapiens	14-17
33584144-6	2021	The urinary RBP/creatinine ratio was an independent risk factor for NAFLD after univariate and multivariate regression analysis, with the or values of 2.271 (1.795-2.872, P < 0.001) and 2.338 (1.775-3.080, P < 0.001), respectively.	Creatinine	16-26	retinol binding protein 4	Homo sapiens	12-15
33584144-7	2021	The prevalence of the urinary RBP/creatinine ratio (groups 1, 2, 3, 4) was 20.0%, 17.3%, 27.3%, and 35.4%, respectively (P < 0.001), and the prevalence of NAFLD in the high urinary RBP/creatinine ratio group was significantly higher than that in the low urinary RBP/creatinine ratio group.	Creatinine	185-195	retinol binding protein 4	Homo sapiens	30-33
33584144-7	2021	The prevalence of the urinary RBP/creatinine ratio (groups 1, 2, 3, 4) was 20.0%, 17.3%, 27.3%, and 35.4%, respectively (P < 0.001), and the prevalence of NAFLD in the high urinary RBP/creatinine ratio group was significantly higher than that in the low urinary RBP/creatinine ratio group.	Creatinine	185-195	retinol binding protein 4	Homo sapiens	30-33
33584144-8	2021	Conclusions: Our results revealed that the urinary RBP/creatinine ratio was an independent risk factor for NAFLD.	Creatinine	55-65	retinol binding protein 4	Homo sapiens	51-54
33553553-8	2021	Based on the multiple regression analyses, the significance of the interaction term (P < 0.05) indicates that both age and sex significantly contribute to the prediction of ln (DHEAs/Creatinine).	Creatinine	183-193	sulfotransferase family 2A member 1	Homo sapiens	177-182
33553553-9	2021	Our fitted model implies the following: as age increases by 1 year, DHEAs/Creatinine is expected to decrease by 3.63% in females and by 2.18% in males.	Creatinine	74-84	sulfotransferase family 2A member 1	Homo sapiens	68-73
33912745-5	2021	The highest quartile of FGF23 was also associated with a substantial increase in risk for the composite endpoint of ESRD, death, or doubling of serum creatinine (hazard ratio [HR] of 2.45 in the fully adjusted model, P = 0.03).	Creatinine	150-160	fibroblast growth factor 23	Homo sapiens	24-29
33436543-4	2021	Overexpression of exogenous MMP-10 ameliorated AKI, manifested by decreased serum creatinine, blood urea nitrogen, tubular injury and apoptosis, and increased tubular regeneration.	Creatinine	82-92	matrix metallopeptidase 10	Homo sapiens	28-34
33413149-5	2021	RESULTS: FGF-23 was positively correlated with fasting blood-glucose, insulin resistance, serum creatinine, serum uric acid, LDL-C, high-sensitivity C-reactive protein, cardiac troponin I and N-terminal-proB-type natriuretic peptide, while was negatively associated with HDL-C and left ventricular ejection fraction (all P < 0.01).	Creatinine	96-106	fibroblast growth factor 23	Homo sapiens	9-15
32915368-7	2021	RESULTS: There was a good correlation between the serum uromodulin concentration and the eGFR value calculated from the creatinine (r = 0.76) and cystatin C (r = 0.79) levels.	Creatinine	120-130	uromodulin	Homo sapiens	56-66
33523719-8	2021	Plasma BDNF and MGP levels were both correlated with the Agatston score even after adjustment for age, total cholesterol level, triglycerides, low-density lipoprotein level, creatinine clearance rate, and the presence of hypertension and diabetes mellitus.	Creatinine	174-184	brain derived neurotrophic factor	Homo sapiens	7-11
33002740-16	2021	Serum IL-18 were correlated with other inflammatory markers and biochemical markers of organ injury; creatinine, liver enzymes and troponin.	Creatinine	101-111	interleukin 18	Homo sapiens	6-11
33254398-4	2021	Each unit increase in maternal urinary lead concentration (mug/g creatinine) was associated with reduced IL-10 (beta = -5.93%, 95%CI: -11.82%, -0.03%) and reduced IL-4 levels (beta = -5.62%, 95%CI: -10.44%, -0.80%).	Creatinine	65-75	interleukin 10	Homo sapiens	105-110
33437955-1	2020	Background: Estimated glomerular filtration (eGFR) results based on serum creatinine are frequently inaccurate with differences against measured GFR (mGFR) often attributed to unmeasured non-functional factors, such as muscle mass.	Creatinine	74-84	Rap guanine nucleotide exchange factor 5	Homo sapiens	46-49
35094884-7	2022	RESULTS: Urinary RBP4/creatinine was inversely correlated with allograft function (r = -0.54, P < .001 with eGFR, and r = 0.49, P < .001 with serum creatinine, respectively).	Creatinine	148-158	retinol binding protein 4	Homo sapiens	17-21
35094884-8	2022	Urinary RBP4/creatinine was higher in rapid renal function decline group than in stable renal function group (184.9 +- 156.7 vs 83.1 +- 99.9, P = .017).	Creatinine	13-23	retinol binding protein 4	Homo sapiens	8-12
35094884-10	2022	In multivariate logistic regression adjusted with recipient age and sex, donor age, number of HLA mismatch, and acute rejection episode, urinary RBP4/creatinine remained a significant factor for rapid renal function decline (OR 9.43, CI 1.99-65.65, P = .010).	Creatinine	150-160	retinol binding protein 4	Homo sapiens	145-149
35094884-11	2022	Receiver operating characteristic analysis showed that the area under the curve of urinary RBP4/creatinine was 0.747 (CI 0.608-0.886, P < .001) for rapid renal function decline.	Creatinine	96-106	retinol binding protein 4	Homo sapiens	91-95
35211307-11	2022	In addition, urinary sediment mRNA of CXCL1 was negatively correlated with eGFR (r = -0.2275, P = 0.0301) and CCL5 level was negatively correlated with eGFR (r = -0.4388, P < 0.0001) and positively correlated with urinary albumin:creatinine ratio (r = 0.2693, P = 0.0098); also, CCL5 and CXCL1 were upregulated in patients with severe renal interstitial fibrosis.	Creatinine	230-240	C-X-C motif chemokine ligand 1	Homo sapiens	38-43
35211307-11	2022	In addition, urinary sediment mRNA of CXCL1 was negatively correlated with eGFR (r = -0.2275, P = 0.0301) and CCL5 level was negatively correlated with eGFR (r = -0.4388, P < 0.0001) and positively correlated with urinary albumin:creatinine ratio (r = 0.2693, P = 0.0098); also, CCL5 and CXCL1 were upregulated in patients with severe renal interstitial fibrosis.	Creatinine	230-240	C-C motif chemokine ligand 5	Homo sapiens	110-114
3436068-1	1987	Urinary excretion of the retinol-binding protein (RBP) was studied in 36 insulin-dependent diabetics with serum creatinine concentrations within the normal range and no microalbuminuria.	Creatinine	112-122	retinol binding protein 4	Homo sapiens	50-53
3619418-5	1987	The regression equation for serum clearance (CLS) versus creatinine clearance (CLCR) was CLS = 1.97 X CLCR + 13.23, where r = 0.697; for renal clearance versus creatinine clearance, the equation was CLR = 2.26 X CLCR, where r = 0.845.	Creatinine	57-67	chymotrypsin C	Homo sapiens	79-83
33541495-12	2020	(2) The PLT levels of the TPO group were significantly higher than those of the control group on the 5th and 7th day after treatment (x109/L: day 5, 63.94+-44.01 vs. 49.85+-29.26, day 7, 125.85+-112.31 vs. 76.81+-50.87, both P < 0.05), and there were no statistically significant differences in PT, PTA, Tn, CK, AST, TBil, Cr, PCT or CRP before and on the 1, 3, 5, 7 days after treatment between TPO and control groups (all P > 0.05).	Creatinine	323-325	thyroid peroxidase	Homo sapiens	26-29
33272156-11	2021	Area under the curve for receiver operating characteristic showed that accuracy of serum creatinine (0.267; 95% CI, 0.11-0.43) at day 0 of cyclosporine treatment was significantly lower (P = .017) than the accuracy of urine creatinine (0.477; 95% CI, 0.28-0.67) and urine levels of the KIM-1 kidney injury molecule (0.594; 95% CI, 0.41-0.78).	Creatinine	89-99	hepatitis A virus cellular receptor 1	Homo sapiens	286-291
3619418-5	1987	The regression equation for serum clearance (CLS) versus creatinine clearance (CLCR) was CLS = 1.97 X CLCR + 13.23, where r = 0.697; for renal clearance versus creatinine clearance, the equation was CLR = 2.26 X CLCR, where r = 0.845.	Creatinine	57-67	chymotrypsin C	Homo sapiens	102-106
3619418-5	1987	The regression equation for serum clearance (CLS) versus creatinine clearance (CLCR) was CLS = 1.97 X CLCR + 13.23, where r = 0.697; for renal clearance versus creatinine clearance, the equation was CLR = 2.26 X CLCR, where r = 0.845.	Creatinine	57-67	chymotrypsin C	Homo sapiens	102-106
3619418-5	1987	The regression equation for serum clearance (CLS) versus creatinine clearance (CLCR) was CLS = 1.97 X CLCR + 13.23, where r = 0.697; for renal clearance versus creatinine clearance, the equation was CLR = 2.26 X CLCR, where r = 0.845.	Creatinine	160-170	chymotrypsin C	Homo sapiens	79-83
3297418-6	1987	Because the renal uptake of proteins involves a saturable process, the urinary excretion of RBP, like that of beta 2-m, specifically reflects the reabsorption capacity of proximal tubules only when the glomerular filtration rate is normal or slightly impaired (i.e., serum creatinine less than 20 mg/L).	Creatinine	273-283	retinol binding protein 4	Homo sapiens	92-95
3590420-0	1987	[Reduced experimental blood creatinine as affected by the SKN enterosorbent].	Creatinine	28-38	hedgehog acyltransferase	Homo sapiens	58-61
3793853-9	1987	Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93).	Creatinine	160-170	oxytocin/neurophysin I prepropeptide	Homo sapiens	8-10
3793853-9	1987	Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93).	Creatinine	160-170	oxytocin/neurophysin I prepropeptide	Homo sapiens	50-52
3793853-9	1987	Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93).	Creatinine	160-170	oxytocin/neurophysin I prepropeptide	Homo sapiens	50-52
3793853-9	1987	Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93).	Creatinine	160-170	oxytocin/neurophysin I prepropeptide	Homo sapiens	50-52
3793853-9	1987	Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93).	Creatinine	160-170	oxytocin/neurophysin I prepropeptide	Homo sapiens	50-52
3793853-10	1987	Mean urinary fractional clearance of OT (OT clearance/creatinine clearance) was 3.6% renal clearance of OT (5.5 ml/min or 0.43% of MCR).	Creatinine	54-64	oxytocin/neurophysin I prepropeptide	Homo sapiens	37-39
3873250-6	1985	Creatinine clearance (GFR) declined by 0.9 ml/min/yr and correlated with both BGP (r = -0.21, P less than 0.001) and AP (r = -0.21, P less than 0.001).	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	22-25
7041504-7	1982	Concomitantly urinary kallikrein increased from 1.1 +/- 0.2 to 2.5 +/- 0.3 units/24 h. Creatinine clearance increased from a mean baseline value of 111 +/- 4 to 123 +/- 4 ml/min during the same period.	Creatinine	87-97	kallikrein related peptidase 4	Homo sapiens	22-32
6914940-9	1981	The urinary excretion rate of kallikrein corrected for creatinine clearance was three times greater in patients with borderline hypertension, but not significantly increased in those with sustained hypertension, compared with that in healthy volunteers.	Creatinine	55-65	kallikrein related peptidase 4	Homo sapiens	30-40
7300106-6	1981	A lineal relationship is established between the beta constant and the creatinine clearance (Clcr) according to the equation beta = 0.001 + 0.005.Clcr, with r = 0,818.	Creatinine	71-81	chymotrypsin C	Homo sapiens	93-97
33140691-2	2021	The aim of this study is to describe the behavior of KIM-1 (Kidney Injury Molecule) and NGAL (Neutrophil Gelatinase Associated Lipocalin) as early predictors of renal damage, comparing them with serum creatinine and creatinine clearance, in neonates undergoing cardiac surgery.	Creatinine	216-226	hepatitis A virus cellular receptor 1	Homo sapiens	53-58
33147835-8	2020	The multivariable logistic regression analysis confirmed that TNC (OR = 1.004 (1.002-1.006), p = 0.0003), fibrinogen (OR= 1.019 (1.005-1.033), p = 0.085), creatinine (OR =1.025 (1.004-1.047), p = 0.0223) and right ventricular end-diastolic dimension (RVEDd) (OR = 1.279 (1.074-1.525), p = 0.0059) were independently associated with resistance to sildenafil treatment.	Creatinine	155-165	tenascin C	Homo sapiens	62-65
32424239-6	2020	Moreover, pretreatment of rats with recombinant human MG53 protein (rhMG53, 2 mg/mL) alleviated iopromide-induced injury in the kidney, which was determined by measuring serum creatinine, blood urea nitrogen and renal histological changes.	Creatinine	176-186	tripartite motif containing 72	Homo sapiens	54-58
33275448-5	2020	Expression of miR-155-5p and miR-223-3p correlated with tacrolimus dose (p < 0.05), miR-223-3p with serum creatinine (p < 0.05), and miR-223-3p and miR-1228-3p with blood leukocytes (p < 0.05).	Creatinine	106-116	microRNA 155	Homo sapiens	14-21
32387092-7	2020	Patients with anti-CFH autoantibodies had a significantly lower prevalence of acute kidney injury (0% (0/10) vs. 40.0%(4/10), P=0.025), lower serum creatinine levels (0.76 (0.40, 1.06) vs. 1.43 (0.46, 11.15), mg/dL, P=0.023), and higher hemoglobin levels (113.8 +- 24.63 vs. 90.0 +- 22.53, g/L, P=0.037) than those who were negative after further stratified analysis.	Creatinine	148-158	complement factor H	Homo sapiens	19-22
32818222-7	2020	Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045).	Creatinine	15-17	netrin 1	Homo sapiens	6-14
32818222-7	2020	Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045).	Creatinine	61-63	netrin 1	Homo sapiens	6-14
32818222-9	2020	ROC curve analysis showed that netrin-1/Cr, MCP-1/CCL-2/Cr, and NGAL/Cr had high predictive values for determining proteinuria p = 0.027, p = 0.041, p = 0.035, respectively).	Creatinine	40-42	netrin 1	Homo sapiens	31-39
32818222-10	2020	Urine hepcidin/Cr was negatively correlated with tubular phosphorus reabsorption and was positively correlated with urine NGAL/Cr (r = -0.418, p = 0.019; r = 0.682, p = 0.000; respectively).	Creatinine	15-17	lipocalin 2	Homo sapiens	122-126
32818222-10	2020	Urine hepcidin/Cr was negatively correlated with tubular phosphorus reabsorption and was positively correlated with urine NGAL/Cr (r = -0.418, p = 0.019; r = 0.682, p = 0.000; respectively).	Creatinine	127-129	lipocalin 2	Homo sapiens	122-126
32487784-9	2020	The serum KIM-1 level positively correlated with microalbuminuria and serum creatinine (r = 0.596, P = 0.001 and r = 0.402, P = 0.034, respectively).	Creatinine	76-86	hepatitis A virus cellular receptor 1	Homo sapiens	10-15
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	98-108	profilin 2	Homo sapiens	0-3
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	148-158	profilin 2	Homo sapiens	0-3
32610429-5	2020	pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels.	Creatinine	148-158	profilin 2	Homo sapiens	0-3
32610429-6	2020	In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (p < 0.0001) and pFL-OPN (p < 0.001) were observed.	Creatinine	44-54	profilin 2	Homo sapiens	128-131
32475043-8	2020	In preterm-born young adults with VLBW, lower urinary alpha-klotho/creatinine was associated with higher SBP, lower urinary Ang-(1-7)/creatinine, and higher urinary Ang II/Ang-(1-7).	Creatinine	134-144	klotho	Homo sapiens	60-66
30309817-8	2020	Based on the evidence reviewed, serum cystatin C and urinary neutrophil gelatinase-associated lipocalin (NGAL) showed a significant correlation with serum creatinine rise postoperatively, emerging as potential noninvasive and early biomarkers of AKI in patients undergoing renal surgery.	Creatinine	155-165	lipocalin 2	Homo sapiens	61-103
30309817-8	2020	Based on the evidence reviewed, serum cystatin C and urinary neutrophil gelatinase-associated lipocalin (NGAL) showed a significant correlation with serum creatinine rise postoperatively, emerging as potential noninvasive and early biomarkers of AKI in patients undergoing renal surgery.	Creatinine	155-165	lipocalin 2	Homo sapiens	105-109
30309817-9	2020	In this setting, serum cystatin C and urinary NGAL have preceded the rise in serum creatinine peak from 3 up to 24h, even in case of mild renal damage.	Creatinine	83-93	lipocalin 2	Homo sapiens	46-50
7300106-6	1981	A lineal relationship is established between the beta constant and the creatinine clearance (Clcr) according to the equation beta = 0.001 + 0.005.Clcr, with r = 0,818.	Creatinine	71-81	chymotrypsin C	Homo sapiens	146-150
7389257-4	1980	Correlations were found between creatinine clearance (Clcr) and ClTB, ClM, and ClR of SCAP (r = 0.92, p less than 0.001; r = 0.84, p less than 0.005; and r = 0.84, p less than 0.005).	Creatinine	32-42	clathrin light chain B	Homo sapiens	64-68
7414255-3	1980	h. Urine was collected separately in the three 2 h periods, and blood was drawn every 1 h. Urinary water, sodium, potassium, chloride, calcium, creatinine and solute excretion increased significantly during the 2-h secretin period.	Creatinine	144-154	secretin	Homo sapiens	215-223
6997987-6	1980	In all uraemic patients G-6-PD activity was positively correlated to serum creatinine (rs = 0.64, P &lt; 0.001) and negatively correlated to haemoglobin (rs = -0.61, P &lt; 0.001.	Creatinine	75-85	glucose-6-phosphate dehydrogenase	Homo sapiens	24-30
7356684-7	1980	In contrast, hypertensive patients with mild renal insufficiency (creatinine clearance of 41.8+/-78.5 ml/min) had reduced (P &lt; 0.05) urinary kallikrein (3.3 EU/24 h with creatinine clearance of 63.6+/-2.0 for 24 black patients and 4.2+/-0.7 EU/24 h with creatinine clearance of 67.0+/-3.5 for 6 white patients).	Creatinine	66-76	kallikrein related peptidase 4	Homo sapiens	144-154
32194547-6	2020	The levels of serum urea, serum creatinine, kidney injury molecule-1 (KIM-1), and histological damage were partially diminished following treatment with IL-9.	Creatinine	32-42	interleukin 9	Mus musculus	153-157
31483944-8	2020	In a multivariate logistic model, both serum and urinary KIM-1 were associated with an increased albumin-to-creatinine ratio (>30 mg/g Cr), but only the serum KIM-1 was associated with a lower eGFR (<60 mL/min/1.73 m2 ), after adjustment for covariates.	Creatinine	108-118	hepatitis A virus cellular receptor 1	Homo sapiens	57-62
7356684-7	1980	In contrast, hypertensive patients with mild renal insufficiency (creatinine clearance of 41.8+/-78.5 ml/min) had reduced (P &lt; 0.05) urinary kallikrein (3.3 EU/24 h with creatinine clearance of 63.6+/-2.0 for 24 black patients and 4.2+/-0.7 EU/24 h with creatinine clearance of 67.0+/-3.5 for 6 white patients).	Creatinine	173-183	kallikrein related peptidase 4	Homo sapiens	144-154
7356684-7	1980	In contrast, hypertensive patients with mild renal insufficiency (creatinine clearance of 41.8+/-78.5 ml/min) had reduced (P &lt; 0.05) urinary kallikrein (3.3 EU/24 h with creatinine clearance of 63.6+/-2.0 for 24 black patients and 4.2+/-0.7 EU/24 h with creatinine clearance of 67.0+/-3.5 for 6 white patients).	Creatinine	173-183	kallikrein related peptidase 4	Homo sapiens	144-154
6933808-0	1980	Prediction of GFR from serum creatinine.	Creatinine	29-39	Rap guanine nucleotide exchange factor 5	Homo sapiens	14-17
7000466-8	1980	In the hypertensives correlations were found between 24 hour kallikrein excretion and potassium excretion (r=0.51; p &lt; 0.05), aldosterone excretion (r=0.57; p &lt; 0.01), and creatinine clearance (r=0.59; p &lt; 0.01).	Creatinine	178-188	kallikrein related peptidase 4	Homo sapiens	61-71
425539-3	1979	Measurements were carried out in 43 azotaemic patients [serum creatinine (SKr) 1.5 to 14.0 mg/100 ml], without evidence of cardiovascular or pulmonary complications of uraemia, of SKr, haemoglobin concentration (Hb) and steady state DLCO.	Creatinine	62-72	tachykinin receptor 2	Homo sapiens	74-77
849998-7	1977	Initial treatment produced small increases in serum creatinine among patients with renal insufficiency, suggesting that GFR was decreased secondary to diuresis-induced volume depletion.	Creatinine	52-62	Rap guanine nucleotide exchange factor 5	Homo sapiens	120-123
5436541-0	1970	Elevated blood pressure, pulse rate and serum creatinine in Negro males deficient in glucose-6-phosphate dehydrogenase.	Creatinine	46-56	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
31950205-7	2020	After renal ischemia and reperfusion injury, TRPC6-/- chimeric mice had an attenuated TRPC6-/- neutrophil recruitment and a better outcome as judged from the reduced increase in the plasma creatinine concentration.	Creatinine	189-199	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	45-50
31843715-9	2020	SAP-drug (anti-TNF-alpha/HGF in SAP hydrogel) treatment reduced the level of serum creatinine (Scr), blood urea nitrogen (BUN), tubular apoptosis, renal inflammatory factors, and macrophage infiltration compared to Free-drug (anti-TNF-alpha/HGF in solution) or SAP alone.	Creatinine	83-93	hepatocyte growth factor	Mus musculus	25-28
32175406-10	2020	An obvious positive correlation was found between pericardial fluid GDF15 and plasma creatinine levels in CAD patients but not in non-CAD patients (R=0.65, P<0.01).	Creatinine	85-95	growth differentiation factor 15	Homo sapiens	68-73
32046440-5	2020	Creatinine-adjusted urinary BPA concentrations were positively correlated with serum MMP2, MMP9 levels, and the risk of peritoneal EMs (third vs lowest quartile: OR 4.92, 95% CI 1.47, 16.50; fourth versus lowest quartile: OR 3.70, 95% CI 1.07, 12.74, Ptrend = 0.030).	Creatinine	0-10	matrix metallopeptidase 9	Homo sapiens	91-95
31933516-9	2020	Negative correlation was observed between miR-122 level and creatinine concentration (P = 0.0028).	Creatinine	60-70	microRNA 122	Homo sapiens	42-49
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 10	Homo sapiens	103-108
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 10	Homo sapiens	109-115
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	interleukin 10	Homo sapiens	157-162
32047847-6	2020	Urine CXCL10 remained stable (ie, &lt;10% degradation) for 8 hours at 25 C or 37 C and for 3 days at 4 C. CXCL10 concentrations [pg/mL] strongly correlated with urine CXCL10/creatinine ratios [ng/mmol] (r2 = 0.98; P &lt; 0.0001).	Creatinine	174-184	C-X-C motif chemokine ligand 10	Homo sapiens	6-12
32047847-6	2020	Urine CXCL10 remained stable (ie, &lt;10% degradation) for 8 hours at 25 C or 37 C and for 3 days at 4 C. CXCL10 concentrations [pg/mL] strongly correlated with urine CXCL10/creatinine ratios [ng/mmol] (r2 = 0.98; P &lt; 0.0001).	Creatinine	174-184	C-X-C motif chemokine ligand 10	Homo sapiens	106-112
32047847-6	2020	Urine CXCL10 remained stable (ie, &lt;10% degradation) for 8 hours at 25 C or 37 C and for 3 days at 4 C. CXCL10 concentrations [pg/mL] strongly correlated with urine CXCL10/creatinine ratios [ng/mmol] (r2 = 0.98; P &lt; 0.0001).	Creatinine	174-184	C-X-C motif chemokine ligand 10	Homo sapiens	106-112
31480863-7	2019	CD47-/- mice were resistant to AKI, with decreased serum creatinine and ameliorated histologic changes compared with WT animals.	Creatinine	57-67	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	0-4
31588916-4	2019	The results showed significant reduction in the body weight, heart rate (HR), hemoglobin contents, serum Ca2+ and reduction in the expression of mRNA of endothelial nitric oxide synthase (eNOS) and nuclear factor erythroid related factor 2 (nrf2) genes in aortic tissues with significant increase in arterial blood pressure (ABP), serum creatinine, blood urea nitrogen (BUN), plasma renin activity (PRA), K+ and phosphate (PO43-), urinary albumin excretion (UAE) and aortic VC in Adenine group compared to normal group (p < 0.05).	Creatinine	337-347	nitric oxide synthase 3	Rattus norvegicus	153-186
31662955-11	2019	The slope of kidney function during five-year follow-up was also not significantly different, but ABO-incompatible recipients did have a lower kidney function at three months (creatinine clearance 58 vs 69 mL/min, P = 0.02, Modification of Diet in Renal Disease 46 vs 52 mL/min/1.73 m2, P = 0.08), due to a high rate of early rejection (33% vs 15%, P = 0.03), mostly T-cell mediated.	Creatinine	176-186	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	98-101
31607953-5	2019	After cisplatin treatment, PINK1 knockout rats showed lower plasma creatinine and less tubular damage when compared with wild-type rats.	Creatinine	67-77	PTEN induced kinase 1	Rattus norvegicus	27-32
32968210-7	2021	We showed that the expression levels of caspase-11 and cleavage of gasdermin D (GSDMD-N) in podocytes were significantly elevated, accompanied by reduced expression of podocyte makers nephrin and podocin, loss and fusion in podocyte foot processes, increased inflammatory cytokines NF-kappaB, IL-1beta, and IL-18, macrophage infiltration, glomerular matrix expansion and increased urinary albumin to creatinine ratio (UACR).	Creatinine	400-410	gasdermin D	Mus musculus	67-78
33906273-0	2021	[Urinary retinol binding protein and beta2-microglobulin were associated with urinary albumin to creatinine ratio and renal function in hospitalized diabetic patients].	Creatinine	97-107	retinol binding protein 4	Homo sapiens	9-32
33906273-1	2021	Objective: To explore the associations of urinary retinol binding protein (RBP) and beta2-microglobulin (beta2-MG) with urinary albumin to creatinine ratio (UACR) and renal function in hospitalized patients with type 2 diabetes mellitus (T2DM).	Creatinine	139-149	retinol binding protein 4	Homo sapiens	50-73
33906273-1	2021	Objective: To explore the associations of urinary retinol binding protein (RBP) and beta2-microglobulin (beta2-MG) with urinary albumin to creatinine ratio (UACR) and renal function in hospitalized patients with type 2 diabetes mellitus (T2DM).	Creatinine	139-149	retinol binding protein 4	Homo sapiens	75-78
33906273-10	2021	Multivariate linear stepwise regression analyses were performed using natural logarithm of urine RBP or beta2-MG as dependent variable, and showed that urine RBP was independently associated with UACR (beta=0.0005, P<0.001), serum creatinine (beta=0.006, P<0.001) and glycosylated hemoglobin A1c (beta=0.050, P=0.001), and beta2-MG was independently correlated with UACR (beta=0.000 4, P<0.001), serum creatinine (beta=0.011, P<0.001), systolic blood pressure (beta=0.005, P=0.031) and fasting blood-glucose (beta=0.027, P=0.046).	Creatinine	231-241	retinol binding protein 4	Homo sapiens	158-161
33906273-10	2021	Multivariate linear stepwise regression analyses were performed using natural logarithm of urine RBP or beta2-MG as dependent variable, and showed that urine RBP was independently associated with UACR (beta=0.0005, P<0.001), serum creatinine (beta=0.006, P<0.001) and glycosylated hemoglobin A1c (beta=0.050, P=0.001), and beta2-MG was independently correlated with UACR (beta=0.000 4, P<0.001), serum creatinine (beta=0.011, P<0.001), systolic blood pressure (beta=0.005, P=0.031) and fasting blood-glucose (beta=0.027, P=0.046).	Creatinine	402-412	retinol binding protein 4	Homo sapiens	158-161
33997033-8	2021	After control factors age, sex, and BMI, urinary CD163 levels in systemic vasculitis patients were positively correlated with serum creatinine, blood urea nitrogen, and beta-2 microglobulin (r = 0.45, 0.48, and 0.46; p = 0.001, 0.001, and 0.002, respectively).	Creatinine	132-142	CD163 molecule	Homo sapiens	49-54
33930896-10	2022	Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026).	Creatinine	167-177	cellular communication network factor 4	Homo sapiens	6-11
31153055-7	2019	RESULTS: After adjustment for HD status, sTM showed a significant positive correlation with serum creatinine, TNFR2, OPN, HGF, SDF1alpha, sVEGFR2, Pi, iPTH, FGF-23, OPG, OC and ON.	Creatinine	98-108	sulfotransferase family 1A member 3	Homo sapiens	41-44
31034908-2	2019	This was ascribed to transient inhibition of MATE1-mediated renal creatinine secretion.	Creatinine	66-76	solute carrier family 47 member 1	Homo sapiens	45-50
31034908-4	2019	The present study was aimed to investigate the translation of in vitro MATE1/2K inhibition to clinical creatinine increase (cobicistat) and lack of it (ritonavir) considering their intracellular concentrations in renal proximal tubules.	Creatinine	103-113	solute carrier family 47 member 1	Homo sapiens	71-76
31434328-3	2019	Specific human protein urinary neutrophil gelatinase-associated lipocalin (uNGAL) and interleukin 18 (uIL-18) levels have been reported to peak specifically at the early stages of AKI before a rise in serum creatinine (sCr).	Creatinine	207-217	lipocalin 2	Homo sapiens	31-73
31277459-5	2019	Results: The determinations of the urinary concentrations of cytokines, chemokines, and creatinine showed that increasing concentrations of C-X-C motif chemokine 10 (CXCL10) also known as interferon-inducible protein 10 (IP10) could be detected during the six-week induction cycle of BCG-treated patients released into the urine by CD14+ cells.	Creatinine	88-98	C-X-C motif chemokine ligand 10	Homo sapiens	140-164
31277459-5	2019	Results: The determinations of the urinary concentrations of cytokines, chemokines, and creatinine showed that increasing concentrations of C-X-C motif chemokine 10 (CXCL10) also known as interferon-inducible protein 10 (IP10) could be detected during the six-week induction cycle of BCG-treated patients released into the urine by CD14+ cells.	Creatinine	88-98	C-X-C motif chemokine ligand 10	Homo sapiens	166-172
31277459-5	2019	Results: The determinations of the urinary concentrations of cytokines, chemokines, and creatinine showed that increasing concentrations of C-X-C motif chemokine 10 (CXCL10) also known as interferon-inducible protein 10 (IP10) could be detected during the six-week induction cycle of BCG-treated patients released into the urine by CD14+ cells.	Creatinine	88-98	C-X-C motif chemokine ligand 10	Homo sapiens	188-219
33629709-0	2021	A novel assay for serum creatinine using a creatine kinase cycling reaction.	Creatinine	24-34	cytidine/uridine monophosphate kinase 1	Homo sapiens	43-58
33629709-3	2021	We have developed a new method that utilizes an enzymatic cycling reaction involving creatine kinase (CK) in the presence of excess ATP and IDP and implicated the application to serum creatinine assay incorporating with creatininase.	Creatinine	184-194	cytidine/uridine monophosphate kinase 1	Homo sapiens	85-100
33629709-3	2021	We have developed a new method that utilizes an enzymatic cycling reaction involving creatine kinase (CK) in the presence of excess ATP and IDP and implicated the application to serum creatinine assay incorporating with creatininase.	Creatinine	184-194	cytidine/uridine monophosphate kinase 1	Homo sapiens	102-104
33629709-4	2021	Here, we evaluated applying the CK cycling method to a serum creatinine assay.	Creatinine	61-71	cytidine/uridine monophosphate kinase 1	Homo sapiens	32-34
33877007-4	2021	The Sequenom detection technology was used for genotyping the single nucleotide polymorphism (SNP) sites of the TRPC1 gene, such as rs1382688, rs3821647, rs7638459, rs953239, and rs7621642.Results: (1) No significant differences were detected in gender, smoking history, drinking history, family history, course of hypertension, fasting blood glucose, urea, creatinine, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycosylated hemoglobin, vitamin D, homocysteine, and cystatin C between the two groups (P > .05).	Creatinine	358-368	transient receptor potential cation channel subfamily C member 1	Homo sapiens	112-117
33870619-6	2021	DCD donors were generally younger, slimmer, less likely to have stroke as a cause of death, with lower terminal creatinines and shorter pancreas cold ischemic times than DBD donors.	Creatinine	112-123	dermcidin	Homo sapiens	0-3
34017511-8	2021	Serum NGAL and NT-proBNP in the patient group were significantly higher than those in the control group, and were positively correlated with changes in blood creatinine.	Creatinine	158-168	lipocalin 2	Homo sapiens	6-10
33853533-5	2021	Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P < 0.05) and was significantly negatively correlated with creatinine (r = - 0.323, P < 0.001), eGFR (r = - 0, P < 0.001) and 24 hUTP (r = - 0.268, P = 0.002).	Creatinine	153-163	angiopoietin like 8	Homo sapiens	6-13
31593848-7	2019	Moreover, serum suPAR and IL-18 levels were negatively correlated with eGFR (rho = -0.734, rho = -0.462, p &lt;0.01) and positively correlated with the urine protein to creatinine ratio (UP/CR) (rho = 0.730, rho = 0.440, p &lt;0.01).	Creatinine	169-179	interleukin 18	Homo sapiens	26-31
20301530-5	1993	The majority of persons with ADTKD-UMOD have the following laboratory test abnormalities: elevated serum creatinine (decreased estimated glomerular filtration rate), bland urinary sediment, elevated serum urate level, and reduced fractional excretion of uric acid.	Creatinine	105-115	uromodulin	Homo sapiens	35-39
33829897-7	2022	CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2 IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.	Creatinine	275-285	TIMP metallopeptidase inhibitor 2	Homo sapiens	68-74
30817089-9	2019	More importantly, Akt and CD9 levels in urinary exosomes were higher in UTI patients than in ABU patients, which was also observed after correction by urine creatinine.	Creatinine	157-167	CD9 molecule	Homo sapiens	26-29
33795029-9	2021	CONCLUSIONS: Detection of significantly higher levels of urinary neutrophil gelatinase-associated lipocalin level and urinary neutrophil gelatinase-associated lipocalin level to creatinine ratio were suggested as urinary neutrophil gelatinase-associated lipocalin level as a non-invasive marker for renal involvement better than microalbumin.	Creatinine	178-188	lipocalin 2	Homo sapiens	126-168
33795029-9	2021	CONCLUSIONS: Detection of significantly higher levels of urinary neutrophil gelatinase-associated lipocalin level and urinary neutrophil gelatinase-associated lipocalin level to creatinine ratio were suggested as urinary neutrophil gelatinase-associated lipocalin level as a non-invasive marker for renal involvement better than microalbumin.	Creatinine	178-188	lipocalin 2	Homo sapiens	126-168
33449454-1	2021	OBJECTIVE: To explore the associations between serum creatinine and creatine kinase (CK) levels with survival in male and female ALS patients.	Creatinine	53-63	cytidine/uridine monophosphate kinase 1	Homo sapiens	85-87
33449454-5	2021	After multivariable Cox regression analysis, lower baseline serum creatinine levels were associated with a short survival in both male (<=61 mumol/L, HR: 1.629; 95%CI: 1.168-2.273) and female ALS patients (<=52 mumol/L, HR: 1.677; 95%CI: 1.042-2.699), whereas, the serum CK levels were not correlated with survival.	Creatinine	66-76	cytidine/uridine monophosphate kinase 1	Homo sapiens	271-273
33629286-14	2021	AQP4 polymorphism rs200498749 was related to fasting blood glucose (p=0.000) and hemoglobin A1c (HbA1c) (p=0.000) in DR group, and polymorphism rs650217 had an association with serum creatinine level (p=0.034).	Creatinine	183-193	aquaporin 4	Homo sapiens	0-4
33535375-4	2021	The serum TWEAK was positively related to serum creatinine (r = 0.356; p < 0.001).	Creatinine	48-58	TNF superfamily member 12	Homo sapiens	10-15
33334757-5	2020	His high urine creatine/creatinine ratio further suggested the diagnosis, later confirmed by hemizygous mutation detected in the SLC6A8 gene.	Creatinine	24-34	solute carrier family 6 member 8	Homo sapiens	129-135
33362965-0	2020	Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.	Creatinine	69-79	matrix metallopeptidase 9	Homo sapiens	8-13
33362965-9	2020	Through multivariate analysis, MMP-9/UCr was found to be associated with albumin concentration and albumin to creatinine ratio.	Creatinine	110-120	matrix metallopeptidase 9	Homo sapiens	31-36
32342614-3	2020	CXCL9/creatinine increased in UTI and BKV viremia with or without nephropathy (BKVN) (no UTI/leukocyturia/UTI: -0.10/1.61/2.09, P=0.0001 and no BKV/viremia/BKVN: -0.10/1.90/2.29, P<0.001) as well as CXCL10/creatinine (1.17/2.09/1.98, P<0.0001 and 1.13/2.21/2.51, P<0.001, respectively).	Creatinine	6-16	C-X-C motif chemokine ligand 10	Homo sapiens	199-205
32881035-10	2020	Changes in NGAL correlated well with changes in serum creatinine (R = 0.79, P < .01) and GFR (R = -0.73, P < .05).	Creatinine	54-64	lipocalin 2	Homo sapiens	11-15
33134397-11	2020	Plasma levels of GDF-15 and TFF3 were highly positively correlated with serum creatinine levels and 24-hour urine protein levels.	Creatinine	78-88	growth differentiation factor 15	Homo sapiens	17-23
33082885-9	2020	The albumin-to-creatinine ratio (ACR) was positively associated with circulating RBP4 concentrations in patients with T2DM [summary Fisher"s Z = 0.20, 95% CI (0.08, 0.32), P = 0.001].	Creatinine	15-25	retinol binding protein 4	Homo sapiens	81-85
32653382-5	2020	Urinary NGAL levels were normalized by urinary creatinine and calculated as uNGAL/creatinine ratios (uNCR).	Creatinine	82-92	lipocalin 2	Homo sapiens	8-12
32863229-4	2020	We found that Klotho haplodeficiency impaired kidney function as evidenced by significant increases in plasma urea and creatinine and a decrease in urinary creatinine in KL+/- mice.	Creatinine	119-129	klotho	Mus musculus	14-20
32863229-4	2020	We found that Klotho haplodeficiency impaired kidney function as evidenced by significant increases in plasma urea and creatinine and a decrease in urinary creatinine in KL+/- mice.	Creatinine	156-166	klotho	Mus musculus	14-20
32991326-4	2020	We observed a negative correlation between IL-21 and creatinine (Cr) levels (P = 0.016).	Creatinine	53-63	interleukin 21	Mus musculus	43-48
32991326-4	2020	We observed a negative correlation between IL-21 and creatinine (Cr) levels (P = 0.016).	Creatinine	65-67	interleukin 21	Mus musculus	43-48
33162804-5	2020	First, we found that the absence of Klotho aggravated diabetic phenotypes indicated by podocyte injury accompanied by elevated urea albumin creatinine ratio (UACR), creatinine and urea nitrogen.	Creatinine	140-150	klotho	Homo sapiens	36-42
33162804-5	2020	First, we found that the absence of Klotho aggravated diabetic phenotypes indicated by podocyte injury accompanied by elevated urea albumin creatinine ratio (UACR), creatinine and urea nitrogen.	Creatinine	165-175	klotho	Homo sapiens	36-42
32972118-8	2022	Anti-PLA2R levels in IMN patients demonstrated a significant positive correlation with serum creatinine and 24-hour urinary protein, while they showed a negative correlation with serum albumin and estimated glomerular filtration rate.	Creatinine	93-103	phospholipase A2 receptor 1	Homo sapiens	5-10
32935918-5	2020	In HFpEF, FGF23 correlated with greater symptom burden (New York Heart Association class: r = 0.308), poorer exercise capacity (6MWT distance: r = -0.345), and plasma biomarkers reflecting inflammation (highly sensitive C-reactive protein: r = 0.207, myeloperoxidase: r = 0.311), bone metabolism (osteoprotegerin: r = 0.446), renal dysfunction (urea: r = 0.267, creatinine: r = 0.351, estimated glomerular filtration rate: r = -0.367), and echocardiographic E/e" (r = 0.298); P < 0.05.	Creatinine	362-372	fibroblast growth factor 23	Homo sapiens	10-15
30506225-10	2019	The creatinine clearance (CLCR) was identified as the most significant covariate in the final model.	Creatinine	4-14	chymotrypsin C	Homo sapiens	26-30
30955247-5	2019	We found that mice treated with PTPN2 displayed reduced serum creatinine, serum BUN and proteinuria.	Creatinine	62-72	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	32-37
30338870-3	2019	GRAIL was derived using objective variables (creatinine, blood urea nitrogen, age, gender, race, and albumin) to estimate GFR based on timing of measurement relative to LT and degree of renal dysfunction (www.bswh.md/grail).	Creatinine	45-55	ring finger protein 128	Homo sapiens	0-5
32765852-5	2020	CCl4 resulted in a significant increase in the serum urea and creatinine levels with detectable degenerative changes in the Bowman"s capsule and glomerulus, with cells exhibiting vacuolization and evidence of necrosis.	Creatinine	62-72	chemokine (C-C motif) ligand 4	Mus musculus	0-4
30787934-8	2019	There was an inverse correlation between miR-152 expression in LN tissue and clinical parameters like 24 h urine protein excretion levels and serum creatinine, but not serum complement levels or SLEDAI.	Creatinine	148-158	microRNA 152	Homo sapiens	41-48
30787934-11	2019	Conclusion: miR-152 expression was tapered in LN tissue and miR-152 expression was inversely correlated with chronicity index (CI), serum creatinine and severity of proteinuria.	Creatinine	138-148	microRNA 152	Homo sapiens	60-67
33536822-3	2019	The aim of this study was to evaluate the predictive power of serum lactate and creatinine levels for mortality and morbidity in lower extremity NF.	Creatinine	80-90	neurofascin	Homo sapiens	145-147
33536822-10	2019	Conclusion: Based on the results of this study, it was determined that risk factors for mortality include age, late presentation, increased serum creatinine and lactate levels, and that these factors can predict the rate of death from NF at the time of presentation.	Creatinine	146-156	neurofascin	Homo sapiens	235-237
32739204-5	2020	Knockdown of DcR2 decreased the expression of alpha-smooth muscle actin, collagen I, fibronectin and serum creatinine levels in streptozotocin-induced mice.	Creatinine	107-117	TNF receptor superfamily member 10d	Homo sapiens	13-17
32475043-6	2020	Among those born preterm, lower alpha-klotho/creatinine was associated with higher systolic BP (adjusted beta (abeta): -2.58 mm Hg, 95% CI -4.99 to -0.17), lower Ang-(1-7)/creatinine (ln abeta: 0.1, 0.04-0.16), and higher Ang II/Ang-(1-7) (ln abeta: -0.14, -0.21 to -0.07).	Creatinine	45-55	klotho	Homo sapiens	38-44
31285802-10	2019	Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively).	Creatinine	6-16	C-X-C motif chemokine ligand 10	Homo sapiens	74-80
32475043-6	2020	Among those born preterm, lower alpha-klotho/creatinine was associated with higher systolic BP (adjusted beta (abeta): -2.58 mm Hg, 95% CI -4.99 to -0.17), lower Ang-(1-7)/creatinine (ln abeta: 0.1, 0.04-0.16), and higher Ang II/Ang-(1-7) (ln abeta: -0.14, -0.21 to -0.07).	Creatinine	172-182	klotho	Homo sapiens	38-44
32475043-8	2020	In preterm-born young adults with VLBW, lower urinary alpha-klotho/creatinine was associated with higher SBP, lower urinary Ang-(1-7)/creatinine, and higher urinary Ang II/Ang-(1-7).	Creatinine	67-77	klotho	Homo sapiens	60-66
32728369-9	2020	Hypertension and creatinine clearance were associated with cTnI and hFABP.	Creatinine	17-27	troponin I3, cardiac type	Homo sapiens	59-63
32116018-3	2020	In Sglt2-/- and littermate wild-type mice (WT), plasma creatinine increased similarly on day 1 (D1) after IR.	Creatinine	55-65	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	3-8
32112355-6	2020	Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio.	Creatinine	104-114	aryl hydrocarbon receptor	Rattus norvegicus	15-18
32112355-6	2020	Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio.	Creatinine	160-170	aryl hydrocarbon receptor	Rattus norvegicus	15-18
31412142-5	2020	Serum proGRP was substantially correlated with serum creatinine (r = 0.637, P < 0.01) and cystain C (0.837, P < 0.01).	Creatinine	53-63	gastrin releasing peptide	Homo sapiens	6-12
31899053-6	2020	RESULTS: Adjusted for anthropometric factors, FGF23 associated positively with creatinine, phosphate, calcium and 25(OH)-vitaminD and negatively with eGFR and calcitriol.	Creatinine	79-89	fibroblast growth factor 23	Homo sapiens	46-51
32225016-6	2020	Active MMP-9 increased at 7 and 14 days post-KT and was restored to baseline levels three months post-KT, coinciding with an improvement in renal function and plasma creatinine.	Creatinine	166-176	matrix metallopeptidase 9	Homo sapiens	7-12
32012216-4	2020	With EMR recognition of transgender patients, a recommendation for estimating creatinine clearance (CLcr) and ideal body weight (IBW) was needed to standardize medication dosing.	Creatinine	78-88	chymotrypsin C	Homo sapiens	100-104
31972158-11	2020	Mir218-2+/- decreased peritubular capillary density at postnatal day 14 and increased serum creatinine after ischemia in adult mice.	Creatinine	92-102	microRNA 218-2	Mus musculus	0-8
31705414-5	2020	The primary outcome was the variation of GFR (%GFR) estimated by the Chronic Kidney Disease - Epidemiology Collaboration (CKD-EPI) formula, calculated using serum creatinine, ethnicity, and gender.	Creatinine	163-173	Rap guanine nucleotide exchange factor 5	Homo sapiens	41-44
30451096-0	2019	Validation of a spectrophotometric method for GGT measurement in canine urine and determination of the urine GGT-to-creatinine ratio reference interval and biological variation in 41 healthy dogs.	Creatinine	116-126	gamma-glutamyltransferase 1	Homo sapiens	109-112
30451096-1	2019	The urine gamma-glutamyl transferase (GGT)-to-creatinine ratio has been used to monitor patients at risk of acute renal injury.	Creatinine	46-56	gamma-glutamyltransferase 1	Homo sapiens	10-36
30451096-1	2019	The urine gamma-glutamyl transferase (GGT)-to-creatinine ratio has been used to monitor patients at risk of acute renal injury.	Creatinine	46-56	gamma-glutamyltransferase 1	Homo sapiens	38-41
30451096-10	2019	The biological variation of urine GGT-to-creatinine ratio provided an index of individuality of 1.6, indicating that a population-based reference interval (RI) can be used.	Creatinine	41-51	gamma-glutamyltransferase 1	Homo sapiens	34-37
30451096-12	2019	The urine GGT-to-creatinine ratio RI obtained in a population of 41 healthy dogs was 8.5-28.5 U/g.	Creatinine	17-27	gamma-glutamyltransferase 1	Homo sapiens	10-13
32541154-2	2020	Whether urinary KIM-1 indexed for creatinine (uKIM-1/Cr) is a prognostic marker of disease progression in ADPKD is unknown.In this secondary analysis of a prospective cohort study, we sought to determine whether patients with high as opposed to low uKIM-1/CR at baseline had greater rates of eGFR loss and height-adjusted total kidney volume (HtTKV) increase.	Creatinine	34-44	hepatitis A virus cellular receptor 1	Homo sapiens	16-21
31770762-4	2019	RESULTS: The addition of sEH inhibition to RAS blockade improved survival rate, further reduced albuminuria and renal glomerular and kidney tubulointerstitial injury, and attenuated the decline in creatinine clearance - all this as compared with 5/6 NX TGR treated with RAS blockade alone.	Creatinine	197-207	epoxide hydrolase 2	Rattus norvegicus	25-28
31310562-10	2020	Results show cigarette smoke increased pulmonary GM-CSF and AM proliferation, and chronically increased pulmonary GM-CSF recapitulated the cardinal features of DIP, including AM accumulation, emphysema, secondary polycythemia, and increased mortality in mice.	Creatinine	160-163	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	114-120
30513528-8	2019	RESULTS: We found a significantly higher urinary concentration of NGAL and NGAL/Cr ratio in newborns from pregnancies complicated by IUGR when compared to the reference group.	Creatinine	80-82	lipocalin 2	Homo sapiens	75-79
30513528-9	2019	We found that female gender was associated with a higher concentration of urinary NGAL and also urinary NGAL/Cr.	Creatinine	109-111	lipocalin 2	Homo sapiens	104-108
30513528-10	2019	CONCLUSIONS: This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants.	Creatinine	103-105	lipocalin 2	Homo sapiens	98-102
30982033-8	2019	At the optimal cutoff value of 0.375 mug/mg urinary creatinine, the initial urinary nephrin displayed sensitivity of 61.5% and specificity of 76.9% for predicting AKI.	Creatinine	52-62	NPHS1 adhesion molecule, nephrin	Homo sapiens	84-91
30580821-11	2019	Patients with IAP above 15mmHg, showed a significant lower baseline estimated glomerular filtration rate (70.7 vs. 44.4mL/min/1.73 m2 with p=0.004], blood urea 36 vs. 83mg/dL with p=0.002]; serum creatinine 0.87 vs. 1.3mg/dL with p=0.004 and cystatin C 1.2 vs. 1.94mg/dL with p= 0.002.	Creatinine	196-206	magnesium transporter 1	Homo sapiens	14-17
30559760-2	2018	Of these variants, rs7805747 in PRKAG2 was identified to be significantly associated with both serum creatinine and CKD with genome wide significance level.	Creatinine	101-111	protein kinase AMP-activated non-catalytic subunit gamma 2	Homo sapiens	32-38
32129195-12	2020	A negative correlation was found between urinary uromodulin and serum creatinine, 24 h urinary proteins and SLICC renal activity score.	Creatinine	70-80	uromodulin	Homo sapiens	49-59
31791262-6	2019	Compared with negative group, patients in the serum PLA2R antibody -positive group had lower serum albumin [SMD = -1.11, 95% CI (- 1.82, - 0.40), P &lt; 0.00001], higher age [MD = 2.71, 95% CI (1.94, 3.48), P &lt; 0.00001], and lower estimated glomerular filtration rate (eGFR) [MD = -10.34, 95% CI (- 12.09, - 8.60), P &lt; 0.00001]; no significant between-group difference was observed with respect to 24-h urine protein and serum creatinine.	Creatinine	433-443	phospholipase A2 receptor 1	Homo sapiens	52-57
31545299-12	2019	Moreover, administration of recombinant annexin A6 in a model of muscular dystrophy reduced serum creatinine kinase, a biomarker of disease.	Creatinine	98-108	annexin A6	Homo sapiens	40-50
31297925-8	2019	TRF2 and TIN2 correlated significantly with hsCRP; additionally, TRF2 showed significant correlation with plasma creatinine and eGFR.	Creatinine	113-123	telomeric repeat binding factor 2	Homo sapiens	65-69
30458823-11	2018	Proportion of dendrin negative glomeruli correlated with lower creatinine clearance (CC) at the time of biopsy and the last follow-up (P = 0.010 and P &lt; 0.001, respectively).	Creatinine	63-73	dendrin	Homo sapiens	14-21
30227779-9	2018	intragastrically 5 days a week) significantly prevented the CCl4-dependent increases in alanine transaminase, aspartate transaminase, creatinine, and urea levels, suggesting a protective potential of ZnONPs.	Creatinine	134-144	chemokine (C-C motif) ligand 4	Mus musculus	60-64
30359254-9	2018	Several genes, including UMOD, SHROOM3 and ELMO1 have been strongly associated with renal diseases, and some of their traits, such as eGFR and serum creatinine.	Creatinine	149-159	uromodulin	Homo sapiens	25-29
31724477-5	2019	The peritoneal creatinine clearance inversely correlated with the protein expression of claudin-1 (r= -0.369, p= .019), and the dialysate-to-plasma creatinine ratio at 4 h PET correlated with occludin (r = 0.396, p= .011) and inversely correlated with claudin-15 (r= -0.393, p= .012).Conclusion: In PD patients, expression of peritoneal TJ proteins can be estimated from the dialysis effluent and may be used as novel peritoneal biomarkers.	Creatinine	15-25	claudin 1	Homo sapiens	88-97
31343478-13	2019	CONCLUSIONS: Cell cycle arrest biomarkers, TIMP-2 and IGFBP7, improve risk stratification for severe outcomes in patients with stage 1 acute kidney injury by urine output, serum creatinine or both, with risk increasing with each acute kidney injury indicator.	Creatinine	178-188	TIMP metallopeptidase inhibitor 2	Homo sapiens	43-49
31648475-10	2019	(4)Cox risk regression model analysis showed that serum creatinine>=176.8 mumol/L (HR=5.078, 95%CI 1.744-14.723, P=0.001) , CD45 positive (HR=14.504, 95%CI 0.168-0.42, P=0.001) , LDH>=220 IU/L (HR=1.308, 95%CI 1.16-2.417, P=0.015) were independent risk prognostic factors.	Creatinine	56-66	protein tyrosine phosphatase receptor type C	Homo sapiens	124-128
31514337-5	2019	TGFBI concentrations in urine are generally increased in patients with UC when compared to urological and population controls (1321.0 versus 701.3 and 475.6 pg/mg creatinine, respectively).	Creatinine	163-173	transforming growth factor beta induced	Homo sapiens	0-5
31514337-6	2019	However, significantly increased TGFBI was predominantly found in muscle invasive (14,411.7 pg/mg creatinine), high-grade (8190.7 pg/mg) and de novo UC (1856.7 pg/mg; all p < 0.0001).	Creatinine	98-108	transforming growth factor beta induced	Homo sapiens	33-38
31153055-8	2019	In forward stepwise multiple regression, serum creatinine, TNFR2, and OPN were identified as significant, independent predictors of sTM.	Creatinine	47-57	sulfotransferase family 1A member 3	Homo sapiens	132-135
31599432-11	2019	The contents of BUN, ALP, ALT, and CR in rats of SOCS1 overexpression group were significantly lower than those in the DN group.	Creatinine	35-37	suppressor of cytokine signaling 1	Rattus norvegicus	49-54
31807245-7	2019	The lowest levels of urea and creatinine that were validated by high super oxide dismutase (SOD) activity and atrial natriuretic peptide (ANP) level were obtained in the 200 mg/day PHGPB treatment.	Creatinine	30-40	natriuretic peptide A	Rattus norvegicus	110-136
31455390-8	2019	CASE PRESENTATION: Here we describe two cases, a 72-year-old Sinhalese man and a 47-year-old Tamil woman, from Sri Lanka, presenting with overt hypothyroidism; they were found to have elevated creatinine, proteinuria, and elevated creatinine kinase levels.	Creatinine	193-203	sorcin	Homo sapiens	111-114
31455336-7	2019	Moreover, the cases where urine NGAL monomer were present also had significantly higher levels of BUN (median: 18.9 vs 9.6 mmol/L) and creatinine (327.1 vs 168 umol/L).	Creatinine	135-145	lipocalin 2	Homo sapiens	32-36
31219796-10	2019	Results Urinary netrin-1 level was found to be higher in patients with T1D than in healthy controls (590 [interquartile range (IQR) = 811] pg/mg-creatinine [pg/mg-cr] and 396 [IQR = 742] pg/mg-cr, respectively) (p = 0.03).	Creatinine	145-155	netrin 1	Homo sapiens	16-24
29667230-5	2018	We found that HIF-1alpha injection improved the survival of rat with AKI, and the level of creatinine and blood urea nitrogen (BUN) was also increased.	Creatinine	91-101	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-24
31538126-7	2019	Results: There was a moderate negative correlation between the percentage change of creatinine values and the percentage change of KIM-1 values (r = -0.357, p = 0.016).	Creatinine	84-94	hepatitis A virus cellular receptor 1	Homo sapiens	131-136
29244191-10	2018	Creatinine, also an OAT2 substrate, showed saturable uptake with a Km of 854 +- 98 muM.	Creatinine	0-10	solute carrier family 22 member 7	Homo sapiens	20-24
30021605-11	2018	Circulating full-length ANGPTL8 concentrations were positively associated with non-HDL-C, TG and TC levels after adjusting for age, gender, body mass index, high-sensitivity C-reactive protein, alanine aminotransferase, and creatinine.	Creatinine	224-234	angiopoietin like 8	Homo sapiens	24-31
30116500-9	2018	Treatment with PRP attenuated the severity of CP-induced nephrotoxicity as evidenced by suppressed creatinine, blood urea nitrogen (BUN), and N-acetyl glucosaminidase (NAG) levels.	Creatinine	99-109	proline rich protein 2-like 1	Rattus norvegicus	15-18
29858267-7	2018	Patients with D-ATIN/TINU carrying HLA-DQA1*0104/DQB1*0503/DRB1*1405 had higher peak serum creatinine and more severe renal tubulointerstitial inflammatory impairment.	Creatinine	91-101	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	49-53
30002385-5	2018	By contrast, the serum creatinine level was significantly elevated until day 3, indicating that Wnt4 is more sensitive to early tubular injury than serum creatinine.	Creatinine	23-33	Wnt family member 4	Homo sapiens	96-100
29844145-11	2018	The albumin:creatinine ratio was increased in both Ang II treatment groups (P&lt;0.05; P&lt;0.0001).	Creatinine	12-22	angiogenin	Rattus norvegicus	51-54
29684255-8	2018	Fold changes in the gene expression of ET-1, interleukin (IL) 18, and tumor necrosis factor alpha (TNF-alpha) were associated with creatinine peak value.	Creatinine	131-141	interleukin 18	Homo sapiens	45-64
29894593-1	2018	Rising urine NGAL and serum creatinine after 48 hr are potentially useful in predicting persistent creatinine increase in patients with contrast-induced AKI.	Creatinine	99-109	lipocalin 2	Homo sapiens	13-17
29748326-2	2018	Multiple formulas for estimating GFR have been developed that use the readily available endogenous biomarkers creatinine and/or cystatin C.	Creatinine	110-120	Rap guanine nucleotide exchange factor 5	Homo sapiens	33-36
29590173-7	2018	Patients with a lower urinary klotho-to-creatinine ratio (UKCR) were significantly more likely to have diffuse foot process effacement (OR = 0.450, P = 0.010).	Creatinine	40-50	klotho	Homo sapiens	30-36
28004272-8	2018	RESULTS: RBP treatment improved insulin sensitivity, decreased elevated fasting serum glucose levels, and improved serum lipid levels and urinary albumin/creatinine ratios in diabetic mice.	Creatinine	154-164	retinol binding protein 4, plasma	Mus musculus	9-12
29599842-5	2018	In addition, administration of combined simvastatin and kallistatin decreased the blood urea nitrogen and serum creatinine levels in the patients.	Creatinine	112-122	serpin family A member 4	Homo sapiens	56-67
29061648-11	2018	During the follow-up of 20.1+-10.1 months, patients with higher s-Klotho levels showed a reduced risk of kidney adverse outcomes, including serum creatinine doubling and initiation of renal replacement therapy.	Creatinine	146-156	klotho	Homo sapiens	66-72
29048741-9	2018	The CXCL10 cut-off of 53.2 pg/mg Cr had sensitivity of 46.1%, specificity of 93.7%, positive predictive value of 97.7%, and negative predictive value of 60.0%.	Creatinine	33-35	C-X-C motif chemokine ligand 10	Homo sapiens	4-10
31094028-5	2019	RESULTS: Pre-treatment with G-Rb3 at doses of 10 and 20 mg/kg for ten days significantly reversed the increases in serum creatinine (CRE), blood urea nitrogen (BUN) and malondialdehyde (MDA), and decrease in glutathione (GSH) content and superoxide dismutase (SOD) activity.	Creatinine	121-131	stathmin 4	Homo sapiens	30-33
31094028-5	2019	RESULTS: Pre-treatment with G-Rb3 at doses of 10 and 20 mg/kg for ten days significantly reversed the increases in serum creatinine (CRE), blood urea nitrogen (BUN) and malondialdehyde (MDA), and decrease in glutathione (GSH) content and superoxide dismutase (SOD) activity.	Creatinine	133-136	stathmin 4	Homo sapiens	30-33
33061029-8	2019	U-NGAL levels correlated well with the peak post-operative creatinine as compared to P-NGAL.	Creatinine	59-69	lipocalin 2	Homo sapiens	2-6
31372130-9	2019	Moderate positive association were seen for KIM1 with creatinine levels (r=0.530; p&lt;0.001), and HbA1c (r=0.576; p&lt;0.001) in all patients.	Creatinine	54-64	hepatitis A virus cellular receptor 1	Homo sapiens	44-48
31372130-11	2019	Multiple logistic regression controlling for age showed that KIM1 was independently associated with BUN (r=0.727; p&lt;0.001), creatinine (r=0.510; p&lt;0.001) and HbA1c (r=0.401; p=0.008) in all groups.	Creatinine	127-137	hepatitis A virus cellular receptor 1	Homo sapiens	61-65
32123869-13	2019	Levels of urine Klotho adjusted by creatinine (Cr) were lower and serum intact FGF23 levels were higher in AKI patients vs. ICU controls.	Creatinine	35-45	klotho	Homo sapiens	16-22
29434211-5	2018	C23-treated mice also had improved lung histology, less TUNEL-positive cells, lower serum levels of creatinine (34%) and BUN (26%), and lower kidney expression of NGAL (50%) and KIM-1 (86%).	Creatinine	100-110	nucleolin	Mus musculus	0-3
28916390-9	2018	At 24h post-ischaemia, plasma creatinine, BUN and tubular injury were significantly reduced in ST2-/- mice compared with vehicle-treated WT mice, but this protective effect was lost in the STZ-induced hyperglycaemic ST2-/- animals.	Creatinine	30-40	interleukin 1 receptor-like 1	Mus musculus	95-98
32123869-13	2019	Levels of urine Klotho adjusted by creatinine (Cr) were lower and serum intact FGF23 levels were higher in AKI patients vs. ICU controls.	Creatinine	47-49	klotho	Homo sapiens	16-22
32123869-14	2019	In adjusted models, the highest vs. lowest tertile of urine Klotho/Cr was independently associated with an overall 95% lower risk of MAKE-90 (81% lower risk in patients with AKI).	Creatinine	67-69	klotho	Homo sapiens	60-66
32123869-17	2019	When measured in the first 48h of ICU admission or AKI diagnosis, urine Klotho/Cr independently associated with major adverse kidney events, particularly in patients with AKI.	Creatinine	79-81	klotho	Homo sapiens	72-78
29729954-6	2019	Also, urinary levels of C3a and C5a were significantly correlated with serum creatinine, urinary protein and estimated glomerular filtration rate, whereas urinary sC5b-9 was significantly correlated with the latter two (and not serum creatinine).	Creatinine	77-87	complement C3	Homo sapiens	24-27
30864841-4	2019	Mice lacking VDR developed more severe AKI than wild-type (WT) control mice after LPS treatment, which was manifested by marked increases in body weight loss and accumulation of serum blood urea nitrogen and creatinine as well as the magnitude of apoptosis of tubular epithelial cells.	Creatinine	208-218	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	13-16
30975435-6	2019	Pearson"s and Spearman"s correlation test results confirmed that plasma CFHR3 and CFHR5 levels in lupus nephritis patients were positively correlated with proteinuria and levels of creatinine (Cr) and anti-dsDNA (correlation coefficients = 0.491-0.717, P &lt; 0.05), while they were negatively correlated with plasma C3 levels and eGFR [correlation coefficients = -(0.706-0.788), P &lt; 0.05].	Creatinine	181-191	complement factor H related 3	Homo sapiens	72-77
30975435-6	2019	Pearson"s and Spearman"s correlation test results confirmed that plasma CFHR3 and CFHR5 levels in lupus nephritis patients were positively correlated with proteinuria and levels of creatinine (Cr) and anti-dsDNA (correlation coefficients = 0.491-0.717, P &lt; 0.05), while they were negatively correlated with plasma C3 levels and eGFR [correlation coefficients = -(0.706-0.788), P &lt; 0.05].	Creatinine	181-191	complement factor H related 5	Homo sapiens	82-87
30975435-6	2019	Pearson"s and Spearman"s correlation test results confirmed that plasma CFHR3 and CFHR5 levels in lupus nephritis patients were positively correlated with proteinuria and levels of creatinine (Cr) and anti-dsDNA (correlation coefficients = 0.491-0.717, P &lt; 0.05), while they were negatively correlated with plasma C3 levels and eGFR [correlation coefficients = -(0.706-0.788), P &lt; 0.05].	Creatinine	193-195	complement factor H related 3	Homo sapiens	72-77
30975435-6	2019	Pearson"s and Spearman"s correlation test results confirmed that plasma CFHR3 and CFHR5 levels in lupus nephritis patients were positively correlated with proteinuria and levels of creatinine (Cr) and anti-dsDNA (correlation coefficients = 0.491-0.717, P &lt; 0.05), while they were negatively correlated with plasma C3 levels and eGFR [correlation coefficients = -(0.706-0.788), P &lt; 0.05].	Creatinine	193-195	complement factor H related 5	Homo sapiens	82-87
30878215-5	2019	MMP-7 knockout mice experienced higher mortality, elevated serum creatinine, and more severe histologic lesions after ischemic or toxic insults.	Creatinine	65-75	matrix metallopeptidase 7	Mus musculus	0-5
31065383-8	2019	Urinary uromodulin levels were significantly lower in CKD cases compared to both controls and first-degree relatives and correlated negatively with age, serum uric acid, serum creatinine, and systolic BP and positively with CKD-EPI eGFR.	Creatinine	176-186	uromodulin	Homo sapiens	8-18
29636837-2	2018	The biochemical estimation indicated that the BUN and creatinine were significantly increased in group 2 (CCl4) compared to group 1 (normal) which was significantly reduced after treatment with Zingerone in group 3 when compared with group 2.	Creatinine	54-64	chemokine (C-C motif) ligand 4	Mus musculus	106-110
29122892-7	2018	RESULTS: Urinary creatinine-corrected NGAL (uNGALcc, ng/mg) was significantly elevated at V1 in DM+PE+ vs. DM+PE- women (P = 0.01); this remained significant after exclusion of leukocyte-positive samples (5 DM+PE+ and 2 DM+PE-) (P = 0.02).	Creatinine	17-27	lipocalin 2	Homo sapiens	38-42
29952417-5	2018	Furthermore, correlation analysis results indicated that the demethylation levels of the MMP-9 gene promoter region was positively correlated with serum protein levels, urinary albumin to creatinine ratio (UACR), urea and creatinine; and was negatively correlated with GFR.	Creatinine	188-198	matrix metallopeptidase 9	Homo sapiens	89-94
29952417-5	2018	Furthermore, correlation analysis results indicated that the demethylation levels of the MMP-9 gene promoter region was positively correlated with serum protein levels, urinary albumin to creatinine ratio (UACR), urea and creatinine; and was negatively correlated with GFR.	Creatinine	222-232	matrix metallopeptidase 9	Homo sapiens	89-94
28808834-7	2017	Urinary creatinine concentrations for AGAT (p = 0.001) and GAMT (p = 0.05) knockout mice were increased following creatine supplementation.	Creatinine	8-18	guanidinoacetate methyltransferase	Mus musculus	59-63
30697570-7	2019	Baseline and study levels of RBP-4 and beta2M were higher for patients with increases in urine proteinuria and an absolute creatinine increase.	Creatinine	123-133	retinol binding protein 4	Homo sapiens	29-34
31117065-6	2019	RESULTS: Consistent with the development of a polycystic kidney phenotype, control PCK rats showed enlarged kidneys, extensive cyst formation, and early signs of serum creatinine elevation at 12 weeks of age.	Creatinine	168-178	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	83-86
31117065-7	2019	Compared to controls, PCK rats treated with low-dose lixivaptan showed a 26% reduction in % kidney weight/body weight (p < 0.01); a 54% reduction in kidney cystic score (p < 0.001), a histomorphometric measure of cystic burden; a 23% reduction in kidney cAMP levels (p < 0.05), a biochemical marker of disease; and a 13% reduction in plasma creatinine (p < 0.001), indicating preserved renal function.	Creatinine	341-351	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	22-25
31113585-12	2019	CONCLUSION: The serum NGAL might be superior to CysC in predicting the prognosis of HBV-ACLF with the normal creatinine level.	Creatinine	109-119	lipocalin 2	Homo sapiens	22-26
30987577-14	2019	Urinary NGAL concentrations at 48 hours correlated with serum creatinine concentrations at 48 hours (r=0.477, p&lt;0.0001), 72 hours (r=0.488, p&lt;0.0001) and 96 hours (r=0.463, p&lt;0.0001).	Creatinine	62-72	lipocalin 2	Homo sapiens	8-12
28823096-11	2017	Serum albumin, glucose, creatinine, and alanine transaminase increased with DBP treatments.	Creatinine	24-34	D-box binding PAR bZIP transcription factor	Rattus norvegicus	76-79
29578190-11	2017	Serum uromodulin levels showed a positive correlation with serum creatinine (r=0.431; P&lt;0.001) and negative correlation with estimated glomerular filtration rate (r=-0.423; P&lt;0.001).	Creatinine	65-75	uromodulin	Homo sapiens	6-16
28964325-7	2017	Intact IGFBP-4 was positively associated with serum creatinine.	Creatinine	52-62	insulin like growth factor binding protein 4	Homo sapiens	7-14
28953968-1	2017	A cost analysis of urine NGAL (uNGAL) &amp; serum creatinine (sCr) for acute kidney injury (AKI) diagnosis.	Creatinine	50-60	lipocalin 2	Homo sapiens	25-29
28336299-0	2017	Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2.	Creatinine	35-45	POU class 2 homeobox 2	Homo sapiens	84-88
28336299-2	2017	Creatinine is excreted by not only glomerular filtration but also active secretion by organic cation transporters such as organic cation transporter 2 (OCT2).	Creatinine	0-10	POU class 2 homeobox 2	Homo sapiens	152-156
28336299-3	2017	In the present study, we evaluated in vitro inhibitory effect of crizotinib on OCT2 by directly measuring creatinine uptake by OCT2.	Creatinine	106-116	POU class 2 homeobox 2	Homo sapiens	79-83
28336299-7	2017	Furthermore, preincubation of crizotinib inhibited creatinine uptake by OCT2 in an apparently competitive manner.	Creatinine	51-61	POU class 2 homeobox 2	Homo sapiens	72-76
28336299-8	2017	In conclusion, crizotinib at a clinically relevant concentration has the potential to inhibit creatinine transport by OCT2, suggesting an increase of serum creatinine levels in clinical use.	Creatinine	94-104	POU class 2 homeobox 2	Homo sapiens	118-122
28416419-5	2017	Their inhibition potencies against the major creatinine renal transporters, including organic cation transporter 2, organic anion transporter 2, and 2 forms of multidrug and toxin extrusion (MATE1 and MATE2K), were assessed in transporter-transfected cell lines using creatinine as a probe substrate.	Creatinine	45-55	solute carrier family 47 member 1	Homo sapiens	191-196
28847915-7	2017	In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein.	Creatinine	316-326	CD8a molecule	Homo sapiens	82-85
28778196-9	2017	Based on ROC analysis, urinary NGAL (AUC; 0.724, 95%CI 0.491-0.957) outperformed conventional biomarkers (serum creatinine, urine protein, and GFR) in differentiating complete and partial response groups from the nonresponse group.	Creatinine	112-122	lipocalin 2	Homo sapiens	31-35
29416596-4	2018	The titers of the anti-PLA2R antibody from the IMN patients in the urine (10.72+-22.24 RU/mumol, presented as uPLA2R-Ab/urine creatinine) and serum (107.36+-140.93 RU/ml) were higher than those from the SMN patients (0.51+-0.46 RU/mumol, 0.008+-0.029 RU/ml, respectively, p&lt;0.05).	Creatinine	126-136	phospholipase A2 receptor 1	Homo sapiens	23-28
28515179-6	2017	Arg2-/- mice had significantly attenuated kidney injury and lower plasma creatinine and blood urea nitrogen levels after renal IRI.	Creatinine	73-83	arginase type II	Mus musculus	0-4
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	Creatinine	258-268	methylenetetrahydrofolate reductase	Homo sapiens	151-191
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	Creatinine	258-268	methylenetetrahydrofolate reductase	Homo sapiens	193-198
31352157-5	2019	In healthy and diseased human kidneys, increased GHR gene expression was associated with increases in glomerular filtration rate (GFR) and decreases in serum creatinine.	Creatinine	158-168	growth hormone receptor	Homo sapiens	49-52
30636243-8	2019	RESULTS: In patients with gout, the spot urinary uromodulin/creatinine ratio (uUMCR; mg/g) in patients with CKD was significantly lower than that in those without CKD (CKD group: 2.2; non-CKD group: 5.6, p = 0.005).	Creatinine	60-70	uromodulin	Homo sapiens	49-59
30429668-4	2018	In the intensive care unit (ICU) NGAL was measured as a new biomarker of AKI besides serum creatinine (sCrea).	Creatinine	91-101	lipocalin 2	Homo sapiens	33-37
30009421-4	2018	Higher FGF23 levels positively correlated with serum creatinine levels (P &lt; 0.05).	Creatinine	53-63	fibroblast growth factor 23	Homo sapiens	7-12
30247450-10	2018	Transplantation of kidneys cold-preserved with CT-1 increased rat survival and renal function (ie, lower plasma creatinine and higher creatinine clearance) and improved kidney damage markers after transplantation (ie, lower superoxide anion, tumor necrosis factor-alpha, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 and higher NF-kappaB).	Creatinine	112-122	cardiotrophin 1	Rattus norvegicus	47-51
30247450-10	2018	Transplantation of kidneys cold-preserved with CT-1 increased rat survival and renal function (ie, lower plasma creatinine and higher creatinine clearance) and improved kidney damage markers after transplantation (ie, lower superoxide anion, tumor necrosis factor-alpha, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 and higher NF-kappaB).	Creatinine	134-144	cardiotrophin 1	Rattus norvegicus	47-51
28945155-6	2018	OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively.	Creatinine	140-150	solute carrier family 22 member 7	Homo sapiens	0-4
28945155-6	2018	OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively.	Creatinine	140-150	solute carrier family 22 member 7	Homo sapiens	28-32
30205620-7	2018	PE concentrations of ENA-78/VEGF/IL-8/MDC/PCS/indoxyl sulphate correlate with serum creatinine concentrations.	Creatinine	84-94	C-X-C motif chemokine ligand 5	Homo sapiens	21-27
30180818-9	2018	Furthermore KIM-1 data showed a significant increase 2 days before serum creatinine rise in comparison to the corresponding KIM-1 levels in patients who developed AKI (P = 0.001).	Creatinine	73-83	hepatitis A virus cellular receptor 1	Homo sapiens	12-17
29673928-13	2018	Urine NGAL and cystatin-C levels also showed a positive correlation with microalbuminuria (urine albumin-creatinine ratio) in patients with type 2 diabetes mellitus.	Creatinine	105-115	lipocalin 2	Homo sapiens	6-10
30068247-3	2018	The aim was to measure and to correlate the level of urine NGAL (uNGAL) with urea, creatinine, and glomerular filtration rate (GFR) of endurance cycling athletes (n = 19) and physically active individuals (control, n = 17).	Creatinine	83-93	lipocalin 2	Homo sapiens	59-63
28614271-6	2017	Serum anti-PLA2R antibody levels were correlated with serum albumin, serum creatinine, eGFR, and proteinuria.	Creatinine	75-85	phospholipase A2 receptor 1	Homo sapiens	11-16
29907459-5	2018	NLRC5 deficient mice significantly ameliorated renal injury as evidenced by decreased serum creatinine levels, improved morphological injuries, and reduced inflammatory responses versus wild type mice.	Creatinine	92-102	NLR family, CARD domain containing 5	Mus musculus	0-5
28083702-0	2017	Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine.	Creatinine	125-135	lipocalin 2	Homo sapiens	18-60
28430754-14	2017	On PICU day 1, interleukin-18 predicted acute kidney injuryserum creatinine with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin and liver fatty acid binding protein predicted acute kidney injuryserum creatinine with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher (not shown).	Creatinine	65-75	interleukin 18	Homo sapiens	15-29
28430754-15	2017	Interleukin-18 and liver fatty acid binding protein on day 1 acute kidney injury predicted prolonged acute kidney injuryserum creatinine (area under the curve=0.74 and 0.83, respectively).	Creatinine	126-136	interleukin 18	Homo sapiens	0-14
27849678-6	2017	More importantly, CLP-induced sepsis after LPS-preconditioning (two separated doses of LPS administration) was more severe in FcGRIIb-/- mice (as measured by mortality rate, bacteria count in blood, serum cytokines, creatinine, and alanine transaminase).	Creatinine	216-226	hyaluronan and proteoglycan link protein 1	Mus musculus	18-21
29907459-9	2018	NLRC5 deficient mice engrafted with wild type hematopoietic cells had significantly lower serum creatinine and less tubular damage than wild type mice reconstituted with NLRC5 deficient bone marrow.	Creatinine	96-106	NLR family, CARD domain containing 5	Mus musculus	0-5
29523497-14	2018	Elevated serum creatinine (OR 1 3; p=0 046), aspartate aminotransferase (OR 1 5; p=0 075), and potassium (OR 3 6; p=0 0024) were independent predictors of death.	Creatinine	15-25	olfactory receptor family 10 subfamily T member 2	Homo sapiens	27-33
28545421-1	2017	BACKGROUND: The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI).	Creatinine	39-49	BCR activator of RhoGEF and GTPase	Homo sapiens	57-60
28542511-6	2017	We found that higher CYP2A6 activity and TNE was associated with increased lung cancer risk after adjusting for age, sex, race/ethnicity, body mass index, smoking duration, and urinary creatinine (p"s = 0.002).	Creatinine	185-195	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	21-27
28542336-1	2017	A cost analysis of urine NGAL (uNGAL) &amp; serum creatinine (sCr) for acute kidney injury (AKI) diagnosis.	Creatinine	50-60	lipocalin 2	Homo sapiens	25-29
28856234-9	2017	Poor agreement (average 42%) was demonstrated between CKD-EPI CysC and creatinine-based GFR estimates within the investigated GFR ranges, with improved agreement (average 55%) when using the combined CKD-EPI SCr/CysC formula.	Creatinine	71-81	Rap guanine nucleotide exchange factor 5	Homo sapiens	88-91
28856234-9	2017	Poor agreement (average 42%) was demonstrated between CKD-EPI CysC and creatinine-based GFR estimates within the investigated GFR ranges, with improved agreement (average 55%) when using the combined CKD-EPI SCr/CysC formula.	Creatinine	71-81	Rap guanine nucleotide exchange factor 5	Homo sapiens	126-129
27895157-3	2017	Compared with cisplatin-treated wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater increases in urea, creatinine, and KIM-1 levels and more tubular injury and apoptosis, but these effects were attenuated in cisplatin-treated MIOX-/- mice.	Creatinine	120-130	myo-inositol oxygenase	Mus musculus	71-75
28315683-4	2017	The results showed that Ad-klotho significantly reduced serum creatinine (Scr) and blood urea nitrogen (BUN) caused by CsA, and significantly increased creatinine clearance.	Creatinine	62-72	klotho	Homo sapiens	27-33
28315683-4	2017	The results showed that Ad-klotho significantly reduced serum creatinine (Scr) and blood urea nitrogen (BUN) caused by CsA, and significantly increased creatinine clearance.	Creatinine	152-162	klotho	Homo sapiens	27-33
29411937-8	2018	A nephrin-creatinine ratio (NCR) cut-point of 622 ng/mg, the 50th percentile, was associated with a 45.8 times greater odds of having albuminuria in children with nephrinuria above this value.	Creatinine	10-20	NPHS1 adhesion molecule, nephrin	Homo sapiens	2-9
27872146-1	2017	As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically important endogenous compounds, like creatinine and cGMP.	Creatinine	369-379	solute carrier family 22 member 7	Homo sapiens	55-82
27872146-1	2017	As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically important endogenous compounds, like creatinine and cGMP.	Creatinine	369-379	solute carrier family 22 member 7	Homo sapiens	84-88
27872146-1	2017	As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically important endogenous compounds, like creatinine and cGMP.	Creatinine	369-379	solute carrier family 22 member 7	Homo sapiens	90-97
27872146-3	2017	Overall, the literature describing OAT2 is rapidly evolving, with numerous publications contradicting each other regarding the transport mechanism, tissue distribution, and transport of creatinine and cGMP, two important endogenous OAT2 substrates.	Creatinine	186-196	solute carrier family 22 member 7	Homo sapiens	35-39
27852120-7	2017	RESULTS: Urinary levels of KIM-1 significantly decreased after hydronephrosis treatment in patients with unilateral obstruction (1.19 ng/mL vs 0.76 ng/mL creatinine, p = 0.002), additionally KIM-1 was significantly higher in patients with hydronephrosis compared to stone disease patients without radiological evidence of obstruction (1.19 vs 0.64, p = 0.006).	Creatinine	154-164	hepatitis A virus cellular receptor 1	Homo sapiens	27-32
27852120-9	2017	We found that a KIM-1 value of 0.735 ng/mg creatinine had a sensitivity of 75% and specificity of 67% to predict the presence of hydronephrosis in preoperative studies (95% CI 0.58-0.87, p = 0.006).	Creatinine	43-53	hepatitis A virus cellular receptor 1	Homo sapiens	16-21
27797887-10	2017	Each 1-SD lower uromodulin-to-creatinine ratio was associated with a higher adjusted mean peak serum creatinine (0.07 mg/dl per SD; 95% confidence interval, 0.02 to 0.13).	Creatinine	30-40	uromodulin	Homo sapiens	16-26
27797887-10	2017	Each 1-SD lower uromodulin-to-creatinine ratio was associated with a higher adjusted mean peak serum creatinine (0.07 mg/dl per SD; 95% confidence interval, 0.02 to 0.13).	Creatinine	101-111	uromodulin	Homo sapiens	16-26
27797887-11	2017	CONCLUSIONS: Lower uromodulin-to-creatinine ratio is associated with higher odds of AKI and higher peak serum creatinine after cardiac surgery.	Creatinine	33-43	uromodulin	Homo sapiens	19-29
27797887-11	2017	CONCLUSIONS: Lower uromodulin-to-creatinine ratio is associated with higher odds of AKI and higher peak serum creatinine after cardiac surgery.	Creatinine	110-120	uromodulin	Homo sapiens	19-29
28019047-7	2017	RESULTS: The urinary NGAL and UNCR of CKD cats were significantly higher than those of healthy cats (P &lt; .05) and were highly correlated with serum creatinine concentration.	Creatinine	151-161	lipocalin 2	Homo sapiens	21-25
28576439-11	2017	Serum ICAM-1 level was significantly correlated with creatinine and microalbuminuria (p: 0.002 and p: 0.03; respectively).	Creatinine	53-63	intercellular adhesion molecule 1	Homo sapiens	6-12
27582100-4	2016	Serum creatinine, blood urea nitrogen (BUN) level, and renal tubular injury score were significantly increased in CD4creIKK2f/f (CD4xIKK2Delta) and CD4creNEMOf/f (CD4xNEMODelta) mice compared with CD4cre mice after IRI induction.	Creatinine	6-16	CD4 antigen	Mus musculus	114-117
27575989-7	2016	In 7 days, blood urea nitrogen (BUN) and creatinine concentrations had significantly increased in the CCl4 group compared to the control group, whereas the PC and CCl4 co-injected group had significantly decreased BUN and creatinine concentrations compared to the CCl4 group.	Creatinine	222-232	chemokine (C-C motif) ligand 4	Mus musculus	163-167
27575989-7	2016	In 7 days, blood urea nitrogen (BUN) and creatinine concentrations had significantly increased in the CCl4 group compared to the control group, whereas the PC and CCl4 co-injected group had significantly decreased BUN and creatinine concentrations compared to the CCl4 group.	Creatinine	222-232	chemokine (C-C motif) ligand 4	Mus musculus	163-167
27605629-8	2016	The creatinine increases were accompanied by a rise in the levels of urinary renal damage markers [beta-2-microglobulin (B2M), total protein, kidney injury molecule (KIM1), alpha-glutathione S-transferase (aGST), N-acetyl-beta-(d)-glucosaminidase (NAG)].	Creatinine	4-14	hepatitis A virus cellular receptor 1	Homo sapiens	166-170
27062303-8	2016	The estimated GFR was calculated from serum creatinine, age and sex using the CKD-EPI equation.	Creatinine	44-54	Rap guanine nucleotide exchange factor 5	Homo sapiens	14-17
27376891-4	2016	RESULTS: The medians of baseline Cd, beta2-m and RBP concentrations at enrollment were 6.19, 105.38 and 71.84 mug/g creatinine, respectively.	Creatinine	116-126	retinol binding protein 4	Homo sapiens	49-52
28855931-8	2016	The levels of neutrophil gelatinase-associated lipocalin to urine creatinine ratio were significantly higher in the group with delayed graft function at the 24 (P=0.004) and 48 h (P=0.015) points.	Creatinine	66-76	lipocalin 2	Homo sapiens	14-56
28855931-11	2016	CONCLUSION: Urinary interleukin 18 to urine creatinine ratio at 24 h post-transplantation, along with traditional markers such as relative fall in serum creatinine, urine output and other risk factors for delayed graft function, increased the ability to predict delayed graft function.	Creatinine	44-54	interleukin 18	Homo sapiens	20-34
28855931-11	2016	CONCLUSION: Urinary interleukin 18 to urine creatinine ratio at 24 h post-transplantation, along with traditional markers such as relative fall in serum creatinine, urine output and other risk factors for delayed graft function, increased the ability to predict delayed graft function.	Creatinine	153-163	interleukin 18	Homo sapiens	20-34
27600466-8	2016	Both kidney and urinary Wnt4 expression were significantly increased in patients diagnosed with biopsy-proven minimal change disease (MCD) with tubular injury, all of whom nevertheless had normal estimated glomerular filtration rate (eGFR) and serum creatinine.	Creatinine	250-260	Wnt family member 4	Homo sapiens	24-28
27600466-10	2016	In conclusion, this is the first demonstration that increases in both kidney and urinary Wnt4 expression can be detected more sensitively and earlier than serum creatinine after kidney injury.	Creatinine	161-171	Wnt family member 4	Homo sapiens	89-93
27318934-5	2016	The kidney-targeted CBA-PSGT-delivered HGF also strikingly reduced various pathologic and molecular markers in vivo such as the level of collagens (type I and II), blood urea nitrogen (BUN), creatinine, and the expressions of ICAM-1, TIMP-1 and alpha-SMA which play a critical role in obstructive kidney functions.	Creatinine	191-201	hepatocyte growth factor	Rattus norvegicus	39-42
28164592-4	2016	RESULTS: Concentrations of both cathepsin B and procathepsin B in serum and urine were significantly elevated in patients with bladder cell carcinoma (p &lt; 0.0001 for U-procathepsin B, U-procathepsin B/creatinine, and U-cathepsin B/creatinine, p = 0.0001 for U-cathepsin B, p = 0.0002 for S-procathepsin B and p = 0.02 for S-cathepsin B).	Creatinine	204-214	cathepsin B	Homo sapiens	32-43
28164592-4	2016	RESULTS: Concentrations of both cathepsin B and procathepsin B in serum and urine were significantly elevated in patients with bladder cell carcinoma (p &lt; 0.0001 for U-procathepsin B, U-procathepsin B/creatinine, and U-cathepsin B/creatinine, p = 0.0001 for U-cathepsin B, p = 0.0002 for S-procathepsin B and p = 0.02 for S-cathepsin B).	Creatinine	204-214	cathepsin B	Homo sapiens	51-62
28164592-4	2016	RESULTS: Concentrations of both cathepsin B and procathepsin B in serum and urine were significantly elevated in patients with bladder cell carcinoma (p &lt; 0.0001 for U-procathepsin B, U-procathepsin B/creatinine, and U-cathepsin B/creatinine, p = 0.0001 for U-cathepsin B, p = 0.0002 for S-procathepsin B and p = 0.02 for S-cathepsin B).	Creatinine	204-214	cathepsin B	Homo sapiens	51-62
28164592-4	2016	RESULTS: Concentrations of both cathepsin B and procathepsin B in serum and urine were significantly elevated in patients with bladder cell carcinoma (p &lt; 0.0001 for U-procathepsin B, U-procathepsin B/creatinine, and U-cathepsin B/creatinine, p = 0.0001 for U-cathepsin B, p = 0.0002 for S-procathepsin B and p = 0.02 for S-cathepsin B).	Creatinine	204-214	cathepsin B	Homo sapiens	51-62
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 22 member 7	Homo sapiens	162-189
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 47 member 1	Homo sapiens	245-284
26825641-2	2016	Based on current evidence, creatinine can be taken up into renal proximal tubule cells by the basolaterally localized organic cation transporter 2 (OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K.	Creatinine	27-37	solute carrier family 47 member 1	Homo sapiens	286-291
29888290-7	2018	Significant positive correlations of VDBP clearance ratio were found with age, WC, SBP, DBP, TG, glucose, HbA1c, urine VDBP, urine microalbumin, and urine microalbumin/creatinine, and a significant negative correlation was found with the steady-state estimate of beta cell function (B%).	Creatinine	168-178	GC vitamin D binding protein	Homo sapiens	37-41
29194759-5	2018	RESULTS: Urine RBP levels (expressed by RBP/creatinine ratio) in NAFLD patients were significantly higher than controls (median 133.1 mg/g vs 110.7 mg/g; P &lt; .001).	Creatinine	44-54	retinol binding protein 4	Homo sapiens	15-18
29194759-7	2018	The area under curve (AUC) of receiver operating characteristic (ROC) was 0.889 with the 95% confidence interval from 0.867 to 0.912.With a cutoff point of 0.215, the sensitivity and specificity of urine RBP/creatinine ratio in NAFLD prediction were 81.1% and 84.5%, respectively.	Creatinine	208-218	retinol binding protein 4	Homo sapiens	204-207
29713488-2	2018	ALK inhibitors can cause a reversible chronic increase of serum creatinine concentration; however, they rarely induce progressive renal insufficiency.	Creatinine	64-74	ALK receptor tyrosine kinase	Homo sapiens	0-3
27087488-8	2016	Obese patients had significantly higher netrin-1 excretion than the controls (841.68+-673.17 vs. 228.94+-137.25 pg/mg creatinine, p=0.000).	Creatinine	118-128	netrin 1	Homo sapiens	40-48
27087488-9	2016	Urinary netrin-1 level was significantly higher in obese subjects with insulin resistance compared to those without insulin resistance (1142+-1181 vs. 604.9+-589.91 pg/mg creatinine, p=0.001).	Creatinine	171-181	netrin 1	Homo sapiens	8-16
27270293-7	2016	RESULTS: In pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {beta = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [beta = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)].	Creatinine	70-80	hepatitis A virus cellular receptor 1	Homo sapiens	100-105
27270293-7	2016	RESULTS: In pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {beta = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [beta = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)].	Creatinine	296-306	hepatitis A virus cellular receptor 1	Homo sapiens	100-105
27011219-9	2016	RESULTS: The mean urine HSP70:Cr ratio (uHSP70/Cr) prior to treatment was significantly higher in the UTI group (449.86 +- 194.33 pg/mg) than in the control, contamination and non-UTI infection groups (39.93 +- 47.61, 32.43 +- 9.09 and 45.14 +- 19.76, respectively; p = 0.0001).	Creatinine	30-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
27548845-5	2016	CCL2/CXCL10 are reported in relation to urine creatinine (ng/mmol).	Creatinine	46-56	C-X-C motif chemokine ligand 10	Homo sapiens	5-11
26795762-6	2016	RESULTS: Preoperative urine KIM-1/Cr ratio was higher than postoperative 14th day.	Creatinine	34-36	hepatitis A virus cellular receptor 1	Homo sapiens	28-33
26795762-9	2016	CONCLUSION: In renal stone patients, the elevated urine KIM-1/Cr ratio levels increase further according to stone size.	Creatinine	62-64	hepatitis A virus cellular receptor 1	Homo sapiens	56-61
26795762-10	2016	KIM-1/Cr ratio is a promising marker might be helpful in monitoring the damage created by stone disease.	Creatinine	6-8	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
27321055-6	2016	RESULTS: In a multivariable Cox regression model adjusting for age, glomerular filtration rate, and urinary albumin/creatinine ratio, higher urinary KIM-1/creatinine was associated with an increased risk for cardiovascular mortality (HR per SD increase 1.51, 95% confidence intervals 1.03-2.24, P = 0.03).	Creatinine	116-126	hepatitis A virus cellular receptor 1	Homo sapiens	149-154
27321055-6	2016	RESULTS: In a multivariable Cox regression model adjusting for age, glomerular filtration rate, and urinary albumin/creatinine ratio, higher urinary KIM-1/creatinine was associated with an increased risk for cardiovascular mortality (HR per SD increase 1.51, 95% confidence intervals 1.03-2.24, P = 0.03).	Creatinine	155-165	hepatitis A virus cellular receptor 1	Homo sapiens	149-154
27321055-8	2016	CONCLUSION: In elderly men with diabetes, higher urinary KIM-1/creatinine was associated with an increased long-term risk of cardiovascular mortality independently of established markers of diabetic nephropathy.	Creatinine	63-73	hepatitis A virus cellular receptor 1	Homo sapiens	57-62
26538631-7	2016	Each log increase in urine NGAL/creatinine independently associated with a 24% greater risk of cardiovascular events (adjusted hazard ratio [aHR], 1.24; 95% confidence interval [95% CI], 1.06 to 1.45), a 40% greater risk of graft failure (aHR, 1.40; 95% CI, 1.16 to 1.68), and a 44% greater risk of death (aHR, 1.44; 95% CI, 1.26 to 1.65).	Creatinine	32-42	lipocalin 2	Homo sapiens	27-31
26538631-8	2016	Urine KIM-1/creatinine and IL-18/creatinine independently associated with greater risk of death (aHR, 1.29; 95% CI, 1.03 to 1.61 and aHR, 1.25; 95% CI, 1.04 to 1.49 per log increase, respectively) but not with risk of cardiovascular events or graft failure.	Creatinine	33-43	interleukin 18	Homo sapiens	27-32
26538632-8	2016	mTOR pathway inhibition in KIM-1-overexpressing transgenic mice also significantly ameliorated serum creatinine level, proteinuria, tubular injury, and kidney inflammation.	Creatinine	101-111	hepatitis A virus cellular receptor 1	Homo sapiens	27-32
26988732-7	2016	RESULTS: Urine NGAL was markedly increased in ACLF vs. no ACLF patients (108(35-400) vs. 29(12-73)mug/g creatinine; p&lt;0.001) and was an independent predictive factor of ACLF; the independent association persisted after adjustment for kidney function or exclusion of variables present in ACLF definition.	Creatinine	104-114	lipocalin 2	Homo sapiens	15-19
27212567-3	2016	He had a markedly elevated urinary alpha-aminoadipic-acid-semialdehyde (39.6 mmol/mol of creatinine; reference range = 0 to 2) and compound heterozygous mutations in ALDH7A1 (c.446C&gt;A and c.919C&gt;T).	Creatinine	89-99	aldehyde dehydrogenase 7 family member A1	Homo sapiens	166-173
27029589-8	2016	The CK level co-related positively with serum creatinine and estimated lean body mass but there was no relationship between CK and muscle scores and limb function.	Creatinine	46-56	cytidine/uridine monophosphate kinase 1	Homo sapiens	4-6
28534527-6	2018	A 39-fold decrease (P&lt;0.0001) in the levels of creatinine-adjusted urinary 17beta-DHE-Gluc was observed among UGT2B17 (*2/*2) subjects vs subjects with the UGT2B17 (*1/*1) genotype.	Creatinine	50-60	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	89-93
29768278-7	2018	RESULTS: Lower levels of plasma Klotho (1st tertile) were associated with older age, higher prevalence of VD, single/multiple lacunar infarcts and leukoaraiosis, coronary heart disease and stroke, and higher levels of creatinine, homocysteine, and high-sensitivity C-reactive protein.	Creatinine	218-228	klotho	Homo sapiens	32-38
29515302-2	2018	NGAL was measured in both urinary and serum sample of 144 type 2 diabetes individuals stratified into three categories based on urinary albumin-creatinine ratio and 54 control populations with estimated glomerular filtration rate &gt;60 mL/min/1.73 m2 and serum creatinine &lt;1.2 mg/dl.	Creatinine	144-154	lipocalin 2	Homo sapiens	0-4
29515302-2	2018	NGAL was measured in both urinary and serum sample of 144 type 2 diabetes individuals stratified into three categories based on urinary albumin-creatinine ratio and 54 control populations with estimated glomerular filtration rate &gt;60 mL/min/1.73 m2 and serum creatinine &lt;1.2 mg/dl.	Creatinine	262-272	lipocalin 2	Homo sapiens	0-4
29115386-11	2018	The concentrations of blood urea nitrogen and serum creatinine in the PYP + cisplatin group were lower than those in the cisplatin group.	Creatinine	52-62	pyrophosphatase (inorganic) 1	Mus musculus	70-73
28858977-6	2018	RESULTS: Patients" serum uromodulin levels were highest associated with a polymorphism in the UMOD coding region and were significantly correlated with estimated glomerular filtration rate (eGFR) (r = 0.242, P &lt; 0.001) and, in an inverse way, with the albumin-creatinine ratio (r = -0.120, P = 0.012).	Creatinine	263-273	uromodulin	Homo sapiens	25-35
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	Creatinine	179-189	heme oxygenase 1	Rattus norvegicus	39-43
29529602-6	2018	RESULTS: Combined RAS and sEH blockade exhibited additional positive impact on the rat survival rate, further reduced albuminuria, further reduced glomerular and tubulointerstitial injury, and attenuated the decline in creatinine clearance when compared to 5/6 NX TGR subjected to RAS blockade alone.	Creatinine	219-229	epoxide hydrolase 2	Rattus norvegicus	26-29
30064143-13	2018	FGF-23 was positively correlated with creatinine, 1.25(OH)2VitD3 (p &lt; 0.001), baPWV (p = 0.002) and CA-IMT (p = 0.005), and negatively correlated with eGFR (p &lt; 0.001).	Creatinine	38-48	fibroblast growth factor 23	Homo sapiens	0-6
27642395-7	2016	KIM-1 showed a weak negative correlation with creatinine (r = -0.279, p = 0.09), whereas MAU was positively correlated with creatinine in participants with kidney disease with statistical significance (r = 0.556, p = 0.001).	Creatinine	46-56	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
27275158-10	2016	Postoperative 6- and 12-hour NGAL levels in the AKI group correlated with postoperative 36-hour serum creatinine levels.	Creatinine	102-112	lipocalin 2	Homo sapiens	29-33
26995661-8	2016	Multivariate analysis confirmed that urinary COL1A1 mRNA level is an independent predictor of serum creatinine doubling or progressing to end stage renal disease; for each 10-fold increase in urinary COL1A1 mRNA level, there is 15.1% excess in risk (95% confidence interval, 1.9% to 30.4%, p=0.022).	Creatinine	100-110	collagen type I alpha 1 chain	Homo sapiens	45-51
26995661-8	2016	Multivariate analysis confirmed that urinary COL1A1 mRNA level is an independent predictor of serum creatinine doubling or progressing to end stage renal disease; for each 10-fold increase in urinary COL1A1 mRNA level, there is 15.1% excess in risk (95% confidence interval, 1.9% to 30.4%, p=0.022).	Creatinine	100-110	collagen type I alpha 1 chain	Homo sapiens	200-206
27610421-8	2016	CONCLUSIONS: Urinary NGAL levels measured 2-3 hr after surgery were able to distinguish the kinetics of creatinine (sustained AKI vs transient AKI) over the subsequent week.	Creatinine	104-114	lipocalin 2	Homo sapiens	21-25
26823283-6	2016	CD9 correlated strongly with urine creatinine, allowing CD9 to be used for normalization of spot urines.	Creatinine	35-45	CD9 molecule	Homo sapiens	0-3
26823283-6	2016	CD9 correlated strongly with urine creatinine, allowing CD9 to be used for normalization of spot urines.	Creatinine	35-45	CD9 molecule	Homo sapiens	56-59
26351173-6	2016	Orosomucoid 2 &gt;1.81 microg/mg of creatinine could distinguish SRNS-FSGS from SRNS-MCD [AUC 0.84 (CI 0.62-1.0), sensitivity 90 % and specificity 85.5 %].	Creatinine	36-46	orosomucoid 2	Homo sapiens	0-13
26751954-8	2016	Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1) and baseline plasma creatinine in patients with above mentioned complications.	Creatinine	44-54	GC vitamin D binding protein	Homo sapiens	20-24
26751954-8	2016	Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1) and baseline plasma creatinine in patients with above mentioned complications.	Creatinine	44-54	hepatitis A virus cellular receptor 1	Homo sapiens	174-179
26751954-8	2016	Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1) and baseline plasma creatinine in patients with above mentioned complications.	Creatinine	201-211	GC vitamin D binding protein	Homo sapiens	20-24
26727266-7	2016	RESULTS: Contrary to our initial hypothesis, renal function declined more severely in sEH-KO mice as indicated by higher serum creatinine and urea levels.	Creatinine	127-137	epoxide hydrolase 2, cytoplasmic	Mus musculus	86-89
26745339-7	2016	Although NGAL was significantly related to e-GFR, creatinine, urea and albumin in CKD-patients (p &lt; 0.001) and not in the other NCD patients (p &gt; 0.05), only serum creatinine predicted NGAL levels in CKD-patients (p &lt; 0.001).	Creatinine	50-60	lipocalin 2	Homo sapiens	9-13
27847811-10	2016	There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values" p = 0.049, 0.01, and 0.004, resp.).	Creatinine	144-154	interleukin 18	Sus scrofa	178-183
27647947-5	2016	However, urinary Gd-IgA1 levels were higher in patients with IgAN (IgAN, 28.0 +- 17.9; disease controls, 20.6 +- 17.4 units/mg urinary creatinine; P &lt; 0.0001).	Creatinine	135-145	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
26096867-0	2016	Urine Neutrophil Gelatinase Associated Lipocalin to Creatinine Ratio: A Novel Index for Steroid Response in Idiopathic Nephrotic Syndrome.	Creatinine	52-62	lipocalin 2	Homo sapiens	6-48
27642607-11	2016	There were also positive correlations between GDF-15 and age, uric acid, creatinine, and area under the curve for glucose (AUC-G).	Creatinine	73-83	growth differentiation factor 15	Homo sapiens	46-52
30286468-5	2018	Moreover, glomerular C3c and C9 and tubular MASP-2 and Collectin-11 expression in zero-biopsies significantly correlated with serum creatinine at diagnosis of DGF, TCMR or ABMR.	Creatinine	132-142	MBL associated serine protease 2	Homo sapiens	44-50
26463992-10	2016	8 weeks after 5/6 nephrectomy (Nx), blood urea nitrogen and creatinine concentrations were significantly increased in EP2(-/-) 5/6Nx mice as compared to those of WT 5/6Nx mice.	Creatinine	60-70	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	118-121
30056903-9	2018	In a multifactorial analysis, the predictors of endocan levels were creatinine, ICAM, and VCAM predicting 59% of variability.	Creatinine	68-78	endothelial cell specific molecule 1	Homo sapiens	48-55
27505067-11	2016	When NGAL was added to a multivariate model including sepsis, pre-admission serum creatinine and lowest hourly urine output, it outperformed the latter model (plasma p = 0.001; urinary p = 0.048).	Creatinine	82-92	lipocalin 2	Homo sapiens	5-9
28193098-8	2017	NPASc was more effective than ASc in decreasing glucose (56%), cholesterol (33%) and creatinine (51%) levels; serum (16%) and pancreatic (46%) AOPP and renal (48%) TBARS levels when compared with DM + C. albicans group.	Creatinine	85-95	PYD and CARD domain containing	Rattus norvegicus	2-5
26787566-9	2016	Admission plasma NGAL level correlated with renal parameters (BUN, creatinine and eGFR) as well as with left ventricular systolic parameters (ejection fraction and fractional shortening).	Creatinine	67-77	lipocalin 2	Homo sapiens	17-21
27296256-10	2016	Clusterin, MCP-1 and KIM-1 positively and significantly correlated with serum creatinine at the week following the determination of BMs in the multivariate linear regression models adjusted for other confounders.	Creatinine	78-88	hepatitis A virus cellular receptor 1	Homo sapiens	21-26
28103129-8	2017	KIM-1 was the most sensitive marker with a cut-off of 170.4 pg/mg creatinine (sensitivity 91.4%, specificity 59.1%), whereas CA19-9 was the most specific with a cut-off of 51.3 U/mg creatinine (sensitivity 48.9%, specificity 88.0%).	Creatinine	66-76	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
28946192-8	2017	In vivo, in the mice studies, CCl4 administration induced hepatotoxicity and nephrotoxicity by a significant rise in the levels of serum liver biomarkers (gamma glutamyl transferase, lactate dehydrogenase, and aminotransferases) and serum renal biomarkers (urea, creatinine, and uric acid).	Creatinine	263-273	chemokine (C-C motif) ligand 4	Mus musculus	30-34
28884615-6	2017	Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD.	Creatinine	70-80	hepatitis A virus cellular receptor 1	Homo sapiens	15-39
28382566-12	2017	CONCLUSION: These results demonstration that TIMP-2*IGFBP-7 concentration can be used in infants to predict subsequent serum creatinine-defined AKI following CPB.	Creatinine	125-135	TIMP metallopeptidase inhibitor 2	Homo sapiens	45-51
28860791-2	2017	Several other studies have shown that soluble ST2 levels correlate with severity of heart failure (HF), left ventricular ejection fraction, creatinine clearance, B-type natriuretic peptide and C-reactive protein, and are predictors of mortality in HF.	Creatinine	140-150	ST2	Homo sapiens	46-49
28979926-5	2017	RESULTS: Urinary KIM-1 and ANG concentrations were strongly correlated to each other and were significantly and independently associated with cold ischemia time, delayed graft function, and plasma creatinine 10 days after transplantation, indicating that these markers reflect the severity of IRI.	Creatinine	197-207	hepatitis A virus cellular receptor 1	Homo sapiens	17-22
28883853-9	2017	Elevation of NGAL level was observed in 5 of 13 cases with AKI, based on creatinine criteria and 4 of 75 cases without AKI.	Creatinine	73-83	lipocalin 2	Homo sapiens	13-17
27427468-9	2017	In women, serum FGF23 was significantly associated with serum creatinine, cystatin C and estimated glomerular filtration rate in the Spearman correlation analysis.	Creatinine	62-72	fibroblast growth factor 23	Homo sapiens	16-21
27427468-10	2017	FGF23 remained significantly associated with serum creatinine (P = 0.046) and estimated glomerular filtration rate (P = 0.034) after full adjustment.	Creatinine	51-61	fibroblast growth factor 23	Homo sapiens	0-5
28799304-0	2017	Comparison of Two Creatinine Based Equations for Routine Estimation of GFR in a Speciality Clinic for Diabetes.	Creatinine	18-28	Rap guanine nucleotide exchange factor 5	Homo sapiens	71-74
28786061-10	2017	The urinary BDNF/Cr levels were significantly higher in BPH patients with moderate LUTS (8.29+-3.635, P&lt;0.0001) and severe LUTS (11.8+-6.44, P&lt;0.0001) than normal controls (1.71+-0.555).	Creatinine	17-19	brain derived neurotrophic factor	Homo sapiens	12-16
28625358-6	2017	KEY FINDINGS: The BUN and Cr concentrations in the XOR+/+IR mice were increased significantly compared to those in XOR+/-IR and allopurinol-treated XOR+/+IR mice.	Creatinine	26-28	xanthine dehydrogenase	Mus musculus	51-54
28646178-3	2017	We found that GFR was significantly greater, and serum creatinine level was significantly lower in TRPC6 deficient mice.	Creatinine	55-65	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	99-104
27496791-9	2017	Pearson correlation analysis revealed a positive relation of serum chemerin concentrations with body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, C-reactive protein and left atrial diameter.	Creatinine	237-247	retinoic acid receptor responder 2	Homo sapiens	67-75
26551455-9	2015	RESULTS: In diabetic rats, MIAT showed the lower level and its expression is negatively correlated with serum creatinine and BUN.	Creatinine	110-120	myocardial infarction associated transcript	Rattus norvegicus	27-31
26669781-10	2015	Urinary [TIMP-2]*[IGFBP7] increased significantly as early as 4 h after CABG in patients with AKI 2/3 (1.83 +- 2.15 vs. 0.23 +- 0.45, p &lt; 0.05) whereas serum creatinine did not increase until 48 h after surgery.	Creatinine	161-171	TIMP metallopeptidase inhibitor 2	Homo sapiens	9-15
26610845-4	2015	RESULTS Among GFR 1-3 subjects possessing TT genotype of RXRA rs10776909, 75% of patients had nephrotic syndrome, and 37.5% had glomerular hyperfiltration defined as GFR &gt;140 ml/min/1.73 m2, and, consequently, serum creatinine was lower in these patients compared to the remaining subjects (0.67+-0.26 vs. 0.94+-0.34, P=0.014).	Creatinine	219-229	retinoid X receptor alpha	Homo sapiens	57-61
26456520-4	2015	Our results showed that the blockade of CXCL13 significantly reduced urine protein, serum creatinine, and dramatically attenuated renal pathology injury.	Creatinine	90-100	chemokine (C-X-C motif) ligand 13	Mus musculus	40-46
26041079-3	2015	At high conversions the [HAl(Oct)2] so obtained exists predominately as hydride-bridged cyclic oligomers, whereas at low conversion the mixed alkyl/hydride-bridged dimer [(Oct)2Al(mu-H)(mu-Oct)Al(Oct)2] is the major species.	Creatinine	72-79	POU class 2 homeobox 2	Homo sapiens	29-34
28575886-11	2017	The recipients" GSTM1 polymorphism, alone and in combination with donors" GSTM1 and GSTT1, significantly affected the creatinine clearance on discharge day.	Creatinine	118-128	glutathione S-transferase theta 1	Homo sapiens	84-89
28448545-3	2017	As seen previously, mice injected with CCl4 exhibited increased plasma levels of alanine aminotransferase, aspartate aminotransferase, and creatinine; transient body weight loss; and increased lipid peroxidation along with decreased total antioxidant power, glutathione, ATP, and NADPH.	Creatinine	139-149	chemokine (C-C motif) ligand 4	Mus musculus	39-43
28584738-0	2017	Performance Characteristics of Kidney Injury Molecule-1 In Relation to Creatinine, Urea, and Microalbuminuria in the Diagnosis of Kidney Disease.	Creatinine	71-81	hepatitis A virus cellular receptor 1	Homo sapiens	31-55
28584738-3	2017	AIMS: This study was conducted to determine the diagnostic value of serum creatinine, urea, and microalbuminuria (MAU) in relation to the novel biomarker, KIM-1.	Creatinine	74-84	hepatitis A virus cellular receptor 1	Homo sapiens	155-160
28323960-11	2017	Intact FGF23 was positively correlated with serum calcium (R = 0.39, P &lt; 0.001) and negatively correlated with urinary calcium/creatinine ratio (R = -0.27, P = 0.011).	Creatinine	130-140	fibroblast growth factor 23	Homo sapiens	7-12
26121315-9	2015	In human peritoneal dialysis patients, the dialysate to plasma ratio of creatinine positively correlated with the dialysate VEGF-D concentration (P&lt;0.001).	Creatinine	72-82	vascular endothelial growth factor D	Homo sapiens	124-130
26270596-0	2015	Reactivity of Hydride Bridges in High-Spin [3M-3(mu-H)] Clusters (M = FeII, CoII).	Creatinine	14-21	spindlin 1	Homo sapiens	38-42
26116550-8	2015	As previously reported, HGF treatment promoted rapid improvement of kidney function as evidenced by creatinine (Cre) and blood urea nitrogen (BUN) levels.	Creatinine	100-110	hepatocyte growth factor	Mus musculus	24-27
25964218-5	2015	RESULTS: The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-beta levels in both the pretransplantation and early post-transplantation period.	Creatinine	13-23	interleukin 10	Homo sapiens	61-66
25994214-9	2015	Correlation analysis showed that plasma CFH levels inversely correlated with initial serum creatinine, Birmingham Vasculitis Activity Score (BVAS), proportion of total crescents and cellular crescents in renal specimens, and circulating levels of C3a, C5a and Sc5b-9, meanwhile positively correlated with estimated glomerular filtration rate (eGFR), hemoglobin levels and circulating levels of C3.	Creatinine	91-101	complement factor H	Homo sapiens	40-43
26178492-10	2015	Correlation Analysis: T (-24) h urinary Sema3A and urinary NGAL were positively correlated with serum creatinine, APACHE II.	Creatinine	102-112	lipocalin 2	Homo sapiens	59-63
25715988-5	2015	In offspring of both sexes at 12 mo of age, there were no differences in kidney weights, urine output, or urinary sodium excretion; however, prenatal CORT exposure increased the urinary albumin/creatinine ratio and 24-h urinary albumin excretion.	Creatinine	194-204	cortistatin	Mus musculus	150-154
25964575-1	2015	BACKGROUND/AIM: There exist various useful predictive models, such as the Cockcroft-Gault model, for estimating creatinine clearance (CLcr).	Creatinine	112-122	chymotrypsin C	Homo sapiens	134-138
25964575-6	2015	RESULTS: A model for predicting CLcr, which included body surface area, serum creatinine and albumin, was constructed.	Creatinine	78-88	chymotrypsin C	Homo sapiens	32-36
25930108-12	2015	In LPS-induced endotoxemic mice, kallistatin attenuated kidney damage in association with reduced serum creatinine, IL-6 and HMGB1 levels, and increased renal SOCS3 expression.	Creatinine	104-114	serpin family A member 4	Homo sapiens	33-44
25990052-11	2015	In patients with uncontrolled diabetes a positive correlation was obtained between glomerular filtration rate and sE-selectin and a negative correlation between the levels of creatinine and ICAM-1, although there was a positive correlation between (HbA1c) and ICAM-1.	Creatinine	175-185	intercellular adhesion molecule 1	Homo sapiens	190-196
25927597-6	2015	DAPA-treated PCK rats had higher clearances for creatinine (3.1 +- 0.1 vs 2.6 +- 0.2 ml/min) and BUN (1.7 +- 0.1 vs 1.2 +- 0.1 ml/min) after 3 weeks, and developed a 4-fold increase in albuminuria.	Creatinine	48-58	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	13-16
25605813-7	2015	INCB039110 potently inhibited OCT2-mediated uptake of creatinine as well as MATE1-/MATE2-K-mediated efflux of creatinine.	Creatinine	54-64	POU class 2 homeobox 2	Homo sapiens	30-34
25605813-7	2015	INCB039110 potently inhibited OCT2-mediated uptake of creatinine as well as MATE1-/MATE2-K-mediated efflux of creatinine.	Creatinine	110-120	solute carrier family 47 member 1	Homo sapiens	76-81
25402375-8	2015	At both baseline and reevaluation, NGAL was positively correlated with cystatin C (r=0.41, p&lt;0.001), systolic arterial pressure z-score (r=0.3, p=0.031) and creatinine (r=0.32, p=0.010).	Creatinine	160-170	lipocalin 2	Homo sapiens	35-39
24986443-8	2015	Meanwhile, decreased serum creatinine and urea induced by PF4 were also reversed by recombinant mouse IL-17 (rmIL-17).	Creatinine	27-37	interleukin 17A	Mus musculus	102-107
28343234-8	2017	RESULTS Serum endocan levels were positively correlated with proteinuria level, serum creatinine level, serum tumor necrosis factor (TNF)-alpha level, beta2-microglobulin level, and PD drainage volume, but not with urine volume at baseline.	Creatinine	86-96	endothelial cell specific molecule 1	Homo sapiens	14-21
25150156-6	2015	These results were confirmed in the MMKD cohort, in which FGF-23 level was again an effect modifier of the relationship between plasma ADMA level and renal events (doubling of baseline serum creatinine, dialysis, or kidney transplantation) in the adjusted analyses (P&lt;0.01).	Creatinine	191-201	fibroblast growth factor 23	Homo sapiens	58-64
25222013-0	2015	Elevated urinary CXCL10-to-creatinine ratio is associated with subclinical and clinical rejection in pediatric renal transplantation.	Creatinine	27-37	C-X-C motif chemokine ligand 10	Homo sapiens	17-23
25546357-6	2015	The method described herein provides a determination of creatinine in a range of 15-40mgL(-1) with a detection limit of 13.7mgL(-1) and it was successfully used in the detection of creatinine in human urine samples.	Creatinine	56-66	LLGL scribble cell polarity complex component 1	Homo sapiens	86-92
25546357-6	2015	The method described herein provides a determination of creatinine in a range of 15-40mgL(-1) with a detection limit of 13.7mgL(-1) and it was successfully used in the detection of creatinine in human urine samples.	Creatinine	181-191	LLGL scribble cell polarity complex component 1	Homo sapiens	86-92
25624405-7	2015	Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels.	Creatinine	66-76	intercellular adhesion molecule 1	Homo sapiens	48-54
25858606-11	2015	This increase is due to inhibition of tubular creatinine secretion through the OCT2 receptor and does not lead to a real decrease in estimated glomerular filtration rate with algorithms that include serum creatinine.	Creatinine	46-56	POU class 2 homeobox 2	Homo sapiens	79-83
25858606-14	2015	Its use is accompanied by an early and non-progressive increase in serum creatinine due to OCT2 receptor inhibition.	Creatinine	73-83	POU class 2 homeobox 2	Homo sapiens	91-95
25542583-2	2015	We developed a LC-MS/MS method for the analysis of creatinine in the same DBS extract that was used for the analysis of tacrolimus, sirolimus, everolimus, and cyclosporine A in transplant patients with the use of Whatman FTA DMPK-C cards.	Creatinine	51-61	DM1 protein kinase	Homo sapiens	225-229
25284002-9	2015	RESULTS: In AKI patients (n=13), plasma NGAL levels at ICU admission were significantly higher than those at baseline [177 (122-402) vs. 121 (74-158) ng/mL, median (interquartile range), p=0.028], whereas serum creatinine showed no significant change.	Creatinine	211-221	lipocalin 2	Homo sapiens	40-44
25909206-10	2015	We conducted a multiple binary logistic to predict in-hospital mortality which yielded that serum urea, creatinine and prothrombin time made a significant contribution to prediction with an OR 14 (95% CI 12.8 - 16.7 p = 0.03), 2 (95% CI 0.5 - 3.47, p = 0.04), and 2 (95% CI 1.03 - 2.31, p = 0.01) linearly-related.	Creatinine	104-114	olfactory receptor family 10 subfamily K member 2	Homo sapiens	190-195
25372509-4	2014	In particular, we have calculated that a twist-boat conformation is relevant to the reactivity and facial selectivity of hydride reduction of cis-2,6-disubstituted N-acylpiperidones with a small hydride reagent (LiAlH4) but not with a bulky hydride (lithium triisopropylborohydride).	Creatinine	121-128	suppressor of cytokine signaling 2	Homo sapiens	142-147
24933630-9	2014	Serum uromodulin displayed inverse relationships with creatinine (r=-0.39), cystatin C (r=-0.42), and urea (r=-0.30) and, correspondingly, a positive relationship with eGFRCysC (r=0.38, p&lt;0.001 for all).	Creatinine	54-64	uromodulin	Homo sapiens	6-16
25538909-9	2014	Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878).	Creatinine	151-161	lipocalin 2	Homo sapiens	6-10
25283078-9	2014	CNP significantly attenuated the IR-induced increase in BUN and serum creatinine.	Creatinine	70-80	natriuretic peptide C	Rattus norvegicus	0-3
25618122-7	2014	RESULTS: Higher urine GGT activity in the 3rd month after transplantation was associated with significantly higher risk of graft failure (HR=1.063 per each U/g creatinine; 95%Cl:1.004-1.127; p=0.037) in the Cox proportional hazards model.	Creatinine	160-170	inactive glutathione hydrolase 2	Homo sapiens	22-25
25104273-7	2014	Creatinine-cystatin C-based GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	28-31
25104273-10	2014	After 40 months, in patients receiving eicosapentaenoic acid-docosahexaenoic acid compared with placebo, the decline in creatinine-cystatin C-based GFR was 2.1 less (95% confidence interval, 0.6 to 3.6; P&lt;0.01) ml/min per 1.73 m(2); other comparisons were not statistical significant.	Creatinine	120-130	Rap guanine nucleotide exchange factor 5	Homo sapiens	148-151
25118612-7	2014	RESULTS: Injections of AD-AdipoQ significantly increased serum adiponectin levels and reduced the urinary albumin-to-creatinine ratio in diabetic rats (P &lt; 0.05).	Creatinine	117-127	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	26-32
25380933-10	2014	Klotho protein correlated only with age (r = -0.21; P &lt; .05), creatinine (r = -0.21; P &lt; .05), and eGFR (r = -0.31; P &lt; .01).	Creatinine	65-75	klotho	Homo sapiens	0-6
25380933-12	2014	FGF23 predictors were renal function (creatinine concentration; beta = 0.45; P = .0001), HDL (beta = 0.33; P = .003), intraventricular septum thickness (beta = 0.38; P = .0003), and right ventricular systolic pressure (beta = 0.34; P = .003), explaining 70% of FGF23 variability.	Creatinine	38-48	fibroblast growth factor 23	Homo sapiens	0-5
25380934-10	2014	In multivariate analysis, sTfR, creatinine, and age were found to be predictors of GDF15.	Creatinine	32-42	growth differentiation factor 15	Homo sapiens	83-88
25380934-11	2014	In univariate analysis in CHF patients, GDF15 was related to creatinine, erythrocyte count, hemoglobin, hepcidin, and total iron binding capacity and tended to correlate with EF.	Creatinine	61-71	growth differentiation factor 15	Homo sapiens	40-45
25380934-12	2014	In multivariate analysis, hepcidin, creatinine, and EF were found to be predictors of GDF15 in CHF.	Creatinine	36-46	growth differentiation factor 15	Homo sapiens	86-91
28069720-7	2017	Because creatinine is also a substrate of OCT2, MATE1, and MATE2-K, creatinine clearance likely overestimates filtration clearance, whereas the calculated 1-NMN secretion clearance is likely underestimated.	Creatinine	8-18	solute carrier family 47 member 1	Homo sapiens	48-53
24510007-11	2014	The serum IL-21 level was positively correlated with blood urea nitrogen (BUN) and creatinine (Cr), suggesting that the serum IL-21 level is associated with the disease severity of HFRS.	Creatinine	83-93	interleukin 21	Homo sapiens	10-15
24510007-11	2014	The serum IL-21 level was positively correlated with blood urea nitrogen (BUN) and creatinine (Cr), suggesting that the serum IL-21 level is associated with the disease severity of HFRS.	Creatinine	83-93	interleukin 21	Homo sapiens	126-131
28207778-11	2017	Further adjustment for creatinine abrogated the predictive effect of NGAL.	Creatinine	23-33	lipocalin 2	Homo sapiens	69-73
24510007-11	2014	The serum IL-21 level was positively correlated with blood urea nitrogen (BUN) and creatinine (Cr), suggesting that the serum IL-21 level is associated with the disease severity of HFRS.	Creatinine	95-97	interleukin 21	Homo sapiens	10-15
24510007-11	2014	The serum IL-21 level was positively correlated with blood urea nitrogen (BUN) and creatinine (Cr), suggesting that the serum IL-21 level is associated with the disease severity of HFRS.	Creatinine	95-97	interleukin 21	Homo sapiens	126-131
27026339-8	2017	CL/F was 257 L/h and V c/F was 804 L. Creatinine clearance was a significant covariate for CL/F, as were age and body weight for V c/F.	Creatinine	38-48	crooked neck pre-mRNA splicing factor 1	Homo sapiens	0-4
27026339-8	2017	CL/F was 257 L/h and V c/F was 804 L. Creatinine clearance was a significant covariate for CL/F, as were age and body weight for V c/F.	Creatinine	38-48	crooked neck pre-mRNA splicing factor 1	Homo sapiens	91-95
28596840-5	2017	The pronounced changes in serum creatinine were accompanied by increased urinary excretion of beta-2-microglobulin and KIM1.	Creatinine	32-42	hepatitis A virus cellular receptor 1	Homo sapiens	119-123
27797887-4	2017	Multivariable logistic and linear regression analyses were used to evaluate the associations of preoperative urinary uromodulin-to-creatinine ratio with postoperative AKI (defined as a rise in serum creatinine of &gt;0.3 mg/dl or &gt;1.5 times baseline); severe AKI (doubling of creatinine or need for dialysis) and peak postoperative serum creatinine over the first 72 hours.	Creatinine	199-209	uromodulin	Homo sapiens	117-127
27797887-4	2017	Multivariable logistic and linear regression analyses were used to evaluate the associations of preoperative urinary uromodulin-to-creatinine ratio with postoperative AKI (defined as a rise in serum creatinine of &gt;0.3 mg/dl or &gt;1.5 times baseline); severe AKI (doubling of creatinine or need for dialysis) and peak postoperative serum creatinine over the first 72 hours.	Creatinine	199-209	uromodulin	Homo sapiens	117-127
27797887-4	2017	Multivariable logistic and linear regression analyses were used to evaluate the associations of preoperative urinary uromodulin-to-creatinine ratio with postoperative AKI (defined as a rise in serum creatinine of &gt;0.3 mg/dl or &gt;1.5 times baseline); severe AKI (doubling of creatinine or need for dialysis) and peak postoperative serum creatinine over the first 72 hours.	Creatinine	199-209	uromodulin	Homo sapiens	117-127
27797887-7	2017	Lower urinary uromodulin-to-creatinine ratio was associated with higher odds for AKI (odds ratio, 1.49 per 1-SD lower uromodulin; 95% confidence interval, 1.04 to 2.13), which was marginally attenuated after multivariable adjustment (odds ratio, 1.43; 95% confidence interval, 0.99 to 2.07).	Creatinine	28-38	uromodulin	Homo sapiens	14-24
27797887-7	2017	Lower urinary uromodulin-to-creatinine ratio was associated with higher odds for AKI (odds ratio, 1.49 per 1-SD lower uromodulin; 95% confidence interval, 1.04 to 2.13), which was marginally attenuated after multivariable adjustment (odds ratio, 1.43; 95% confidence interval, 0.99 to 2.07).	Creatinine	28-38	uromodulin	Homo sapiens	118-128
27797887-8	2017	The lowest uromodulin-to-creatinine ratio quartile was also associated with higher odds for AKI relative to the highest quartile (odds ratio, 2.94; 95% confidence interval, 1.19 to 7.26), which was slightly attenuated after multivariable adjustment (odds ratio, 2.43; 95% confidence interval, 0.91 to 6.48).	Creatinine	25-35	uromodulin	Homo sapiens	11-21
27797887-9	2017	A uromodulin-to-creatinine ratio below the median was associated with higher adjusted odds for severe AKI, although this did not reach statistical significance (odds ratio, 4.03; 95% confidence interval, 0.87 to 18.70).	Creatinine	16-26	uromodulin	Homo sapiens	2-12
27683625-4	2016	We hypothesized that an increase in GFR would be associated with an increased albumin-to-creatinine ratio in a cohort of the general population.	Creatinine	89-99	Rap guanine nucleotide exchange factor 5	Homo sapiens	36-39
27683625-7	2016	We investigated the association between change in GFR and change in albumin-to-creatinine ratio.	Creatinine	79-89	Rap guanine nucleotide exchange factor 5	Homo sapiens	50-53
27683625-10	2016	RESULTS: Change in GFR was positively associated with a change in albumin-to-creatinine ratio in the entire cohort in the multiple linear regression.	Creatinine	77-87	Rap guanine nucleotide exchange factor 5	Homo sapiens	19-22
27683625-11	2016	The albumin-to-creatinine ratiofollow-up-to-albumin-to-creatinine ratiobaseline ratio increased by 8.0% (95% confidence interval, 1.4 to 15.0) per SD increase in change in GFR.	Creatinine	15-25	Rap guanine nucleotide exchange factor 5	Homo sapiens	172-175
27683625-11	2016	The albumin-to-creatinine ratiofollow-up-to-albumin-to-creatinine ratiobaseline ratio increased by 8.0% (95% confidence interval, 1.4 to 15.0) per SD increase in change in GFR.	Creatinine	55-65	Rap guanine nucleotide exchange factor 5	Homo sapiens	172-175
27683625-14	2016	CONCLUSIONS: Increasing GFR is associated with an increase in albumin-to-creatinine ratio and incident albuminuria in the general nondiabetic population.	Creatinine	73-83	Rap guanine nucleotide exchange factor 5	Homo sapiens	24-27
27958261-6	2016	RESULTS Among patients with CKD, serum uromodulin concentrations were significantly lower than in controls, and were strongly negatively correlated with renal retention markers (ie, serum creatinine and cystatin C) and strongly positively correlated with eGFR.	Creatinine	188-198	uromodulin	Homo sapiens	39-49
27958261-7	2016	An inverse, hyperbolic relationship between serum creatinine and uromodulin levels was analogous to the well-known association between serum creatinine concentrations and eGFR.	Creatinine	50-60	uromodulin	Homo sapiens	65-75
27958261-7	2016	An inverse, hyperbolic relationship between serum creatinine and uromodulin levels was analogous to the well-known association between serum creatinine concentrations and eGFR.	Creatinine	141-151	uromodulin	Homo sapiens	65-75
26711244-7	2016	Cases with &gt;1 CD44+ cell (PECs and VECs) per glomerulus were associated with increased urine protein/creatinine ratio (UPCr) at last follow-up.	Creatinine	104-114	CD44 molecule (Indian blood group)	Homo sapiens	17-21
24712576-6	2014	RESULTS: Patients with PHA1 had higher morning plasma cortisol (816 +- 85 vs 586 +- 50 nmol/L, P = .02) and increased 24-hour urinary excretion of cortisol metabolites (985 +- 150 vs 640 +- 46 mug/mmol creatinine, P = .03), independently of gender.	Creatinine	202-212	sodium channel epithelial 1 subunit gamma	Homo sapiens	23-27
26711244-8	2016	The presence of &gt;1 CD44+ VEC/glomerulus was associated with increased UPCr and serum creatinine levels, and decreased estimated glomerular filtration rate (eGFR) even in the absence of SS at the time of biopsy.	Creatinine	88-98	CD44 molecule (Indian blood group)	Homo sapiens	22-26
27132791-1	2016	BACKGROUND: This study was designed to determine the diagnostic role of urinary kidney injury molecule (KIM)-1 levels in renal damage in patients with type 2 diabetes mellitus according to the urinary albumin/creatinine ratio.	Creatinine	209-219	hepatitis A virus cellular receptor 1	Homo sapiens	104-110
27132791-8	2016	Positive correlation was found between KIM-1 and urine microalbumin-urine microalbumin/creatinine (r = 0.479 P &lt; 0.001; r = 0.	Creatinine	87-97	hepatitis A virus cellular receptor 1	Homo sapiens	39-44
27858892-6	2016	The area under the receiver operating characteristic curve (AUC-ROC) of serum KIM-1 for identifying renal dysfunction in all enrolled patients was 0.94 (95% confidence interval [95% CI], 0.87 to 1.02; P &lt; 0.001), while the AUC-ROC of serum creatinine was only 0.82 (95% CI, 0.60 to 1.03; P &lt; 0.01).Serum KIM-1 is a promising new diagnostic biomarker of renal dysfunction during long-term ADV therapy for CHB patients.	Creatinine	243-253	hepatitis A virus cellular receptor 1	Homo sapiens	78-83
27756187-2	2016	Our aim was to examine the association between serum endocan levels and urine albumin-creatinine ratio (UACR).	Creatinine	86-96	endothelial cell specific molecule 1	Homo sapiens	53-60
27799234-8	2016	In a multivariable model, in patients with normal BMI, low creatinine (&lt;=0.70 mg/dL) was significantly associated with increased all-cause mortality (HR 1.8, 95% CI 1.3-2.5) and cardiovascular mortality (HR 2.3, 95% CI 1.4-3.8) compared with patients with normal creatinine (0.71-1.0 mg/dL); however, this was not observed in other BMI categories.	Creatinine	59-69	RAD18 E3 ubiquitin protein ligase	Homo sapiens	153-159
27717384-13	2016	In random forest analyses the predictive capacity of GDF-15 was especially pronounced in patients with normal plasma creatinine.	Creatinine	117-127	growth differentiation factor 15	Homo sapiens	53-59
27717384-14	2016	CONCLUSION: This suggests that preoperative plasma GDF-15 independently predicts postoperative AKI in patients undergoing elective cardiac surgery and is particularly helpful for risk stratification in patients with normal creatinine.	Creatinine	223-233	growth differentiation factor 15	Homo sapiens	51-57
27332746-10	2016	The multivariate analysis showed that the use of TDF was independently associated with a higher risk of altered excretion of RBP/creatinine (4.4; interquartile range: 1.4 to 14; P=0.013).	Creatinine	129-139	retinol binding protein 4	Homo sapiens	125-128
25923545-9	2016	RESULTS: KIM-1 levels were found to be 0.86+-0.48 ng/mg creatinine in the patient, and 0.71+-0.46 pg/mL in the control groups (P&gt;0.05).	Creatinine	56-66	hepatitis A virus cellular receptor 1	Homo sapiens	9-14
24646860-0	2014	Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.	Creatinine	127-137	solute carrier family 22 member 7	Homo sapiens	46-50
24646860-0	2014	Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.	Creatinine	92-102	solute carrier family 22 member 7	Homo sapiens	46-50
24646860-3	2014	The basolateral uptake transporters organic anion transporter OAT2 and organic cation transporters OCT2 and OCT3 were found to transport creatinine.	Creatinine	137-147	solute carrier family 22 member 7	Homo sapiens	62-66
24646860-3	2014	The basolateral uptake transporters organic anion transporter OAT2 and organic cation transporters OCT2 and OCT3 were found to transport creatinine.	Creatinine	137-147	POU class 2 homeobox 2	Homo sapiens	99-103
24646860-3	2014	The basolateral uptake transporters organic anion transporter OAT2 and organic cation transporters OCT2 and OCT3 were found to transport creatinine.	Creatinine	137-147	solute carrier family 22 member 3	Homo sapiens	108-112
24646860-4	2014	At physiologic creatinine concentrations, the specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3, establishing OAT2 as a likely relevant creatinine transporter and further challenging the traditional view that creatinine is solely transported by a cationic pathway.	Creatinine	15-25	solute carrier family 22 member 7	Homo sapiens	67-71
24646860-4	2014	At physiologic creatinine concentrations, the specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3, establishing OAT2 as a likely relevant creatinine transporter and further challenging the traditional view that creatinine is solely transported by a cationic pathway.	Creatinine	164-174	solute carrier family 22 member 7	Homo sapiens	67-71
24646860-4	2014	At physiologic creatinine concentrations, the specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3, establishing OAT2 as a likely relevant creatinine transporter and further challenging the traditional view that creatinine is solely transported by a cationic pathway.	Creatinine	164-174	solute carrier family 22 member 7	Homo sapiens	138-142
24646860-6	2014	All drugs known to affect creatinine inhibited OCT2 and MATE1.	Creatinine	26-36	POU class 2 homeobox 2	Homo sapiens	47-51
24646860-6	2014	All drugs known to affect creatinine inhibited OCT2 and MATE1.	Creatinine	26-36	solute carrier family 47 member 1	Homo sapiens	56-61
24646860-7	2014	Similar to cimetidine and ritonavir, cobicistat had the greatest effect on MATE1 with a 50% inhibition constant of 0.99 muM for creatinine transport.	Creatinine	128-138	solute carrier family 47 member 1	Homo sapiens	75-80
24646860-10	2014	Thus, the clinical observation of elevated serum creatinine in patients taking cobicistat is likely a result of OCT2 transport, facilitating intracellular accumulation, and MATE1 inhibition.	Creatinine	49-59	POU class 2 homeobox 2	Homo sapiens	112-116
24646860-10	2014	Thus, the clinical observation of elevated serum creatinine in patients taking cobicistat is likely a result of OCT2 transport, facilitating intracellular accumulation, and MATE1 inhibition.	Creatinine	49-59	solute carrier family 47 member 1	Homo sapiens	173-178
24459137-8	2014	Vascular FGF23 expression correlated with declining kidney function, as evidenced by reduced creatinine clearance.	Creatinine	93-103	fibroblast growth factor 23	Homo sapiens	9-14
25023056-2	2014	Recently, the serum cystatin C and plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) levels have been introduced as early biomarkers for AKI; the levels of these biomarkers are known to increase 24 to 48 hours before the serum creatinine levels increase.	Creatinine	244-254	lipocalin 2	Homo sapiens	96-100
24656453-5	2014	PREDICTORS: Ratios of urine KIM-1, IL-18, and albumin to creatinine (KIM-1:Cr, IL-18:Cr, and ACR, respectively).	Creatinine	57-67	hepatitis A virus cellular receptor 1	Homo sapiens	69-74
24656453-5	2014	PREDICTORS: Ratios of urine KIM-1, IL-18, and albumin to creatinine (KIM-1:Cr, IL-18:Cr, and ACR, respectively).	Creatinine	57-67	interleukin 18	Homo sapiens	79-84
27267546-6	2016	RESULTS: After renal ischemia-reperfusion, Cirp(-/-) mice demonstrated a reduction of blood urea nitrogen and creatinine of 53% and 60%, respectively, compared with wild-type mice.	Creatinine	110-120	cold inducible RNA binding protein	Mus musculus	43-47
27032082-7	2016	In women, serum CTSB remained significantly associated with serum creatinine (SCr) (p=0.009), estimated glomerular filtration rate (p=0.048) and IMT/D (p=0.017) following full adjustment.	Creatinine	66-76	cathepsin B	Homo sapiens	16-20
27466997-8	2016	Creatinine levels significantly differed (p = 0.009) between three s-Klotho-level sub-groups, with the high creatinine levels in the sub-group with the lowest s-Klotho levels and estimated glomerular filtration rate (eGFR).	Creatinine	0-10	klotho	Homo sapiens	69-75
24751973-4	2014	Pre-treatment with CS-P significantly attenuated the deleterious renal functions caused by LPS, i.e., elevated blood urea nitrogen and creatinine as well as urine protein.	Creatinine	135-145	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	19-23
24598218-14	2014	The number of t-Kim-1 cells at baseline was significantly correlated with the estimated glomerular filtration rate (R = 0.72; P = 0.005) and serum creatinine (R = 0.53; P = 0.005) after 6-8 months of treatment.	Creatinine	147-157	hepatitis A virus cellular receptor 1	Homo sapiens	16-21
24923556-7	2014	RESULTS: In both males and females, GPR30 gene deletion was associated with reduced serum creatinine regardless of treatment.	Creatinine	90-100	G protein-coupled estrogen receptor 1	Mus musculus	36-41
24923556-19	2014	Of significance to further investigation, GPR30 gene deletion was associated with reduced serum creatinine, regardless of treatment.	Creatinine	96-106	G protein-coupled estrogen receptor 1	Mus musculus	42-47
24918752-4	2014	RESULTS: All biomarker protein concentrations increased after transplantation, and urinary NGAL and IL-18 at 24 and 168 h correlated with the day 7 creatinine reduction ratio (CRR).	Creatinine	148-158	lipocalin 2	Homo sapiens	91-95
24918752-4	2014	RESULTS: All biomarker protein concentrations increased after transplantation, and urinary NGAL and IL-18 at 24 and 168 h correlated with the day 7 creatinine reduction ratio (CRR).	Creatinine	148-158	interleukin 18	Homo sapiens	100-105
27273361-6	2016	Interestingly, diabetic heterozygous Cav2.2(+/-) mice also decreased albuminuria, although they exhibited comparable systolic blood pressure, sympathetic nerve activity and creatinine clearance to diabetic Cav2.2(+/+) mice.	Creatinine	173-183	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	37-43
26511274-6	2016	In chronic HF, plasma KIM-1 was associated with GFR (P &lt; 0.001), creatinine, and cystatin C.	Creatinine	68-78	hepatitis A virus cellular receptor 1	Homo sapiens	22-27
24352152-4	2014	Wild-type mice pretreated with rHMGB1 before ischemia were protected against kidney ischemia-reperfusion injury, indicated by lower serum creatinine, less tubular damage, less tubulointerstitial neutrophil and macrophage infiltration, and less tubular epithelial cell apoptosis versus control mice.	Creatinine	138-148	high mobility group box 1	Rattus norvegicus	31-37
24667016-4	2014	We sought to investigate in young patients with type1 diabetes whether pi-Glutathione S-transferase to creatinine (pi-GST:crea) and Tamm-Horsfall protein to creatinine (THP:crea) ratios, markers of distal tubular renal function, relate to subclinical markers of arterial disease, which appear to onset early and develop rapidly in type1 diabetes.	Creatinine	157-167	uromodulin	Homo sapiens	169-172
24667560-8	2014	RESULTS: TRAIL(-/-)ApoE(-/-) mice had significantly increased urine protein, urine protein:creatinine ratio, plasma phosphorous, and plasma cystatin C, with accelerated nephropathy.	Creatinine	91-101	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	9-14
24851612-10	2014	There were also moderate positive correlation (0.500 and 0.502) between urine NGAL values and percentage difference of serum creatinine and creatinine clearence.	Creatinine	125-135	lipocalin 2	Homo sapiens	78-82
24851612-10	2014	There were also moderate positive correlation (0.500 and 0.502) between urine NGAL values and percentage difference of serum creatinine and creatinine clearence.	Creatinine	140-150	lipocalin 2	Homo sapiens	78-82
24851612-11	2014	All that indicate that higer values of urine NGAL are followed by higher percentage difference of serume creatinine and creatinine clearence.	Creatinine	105-115	lipocalin 2	Homo sapiens	45-49
24851612-11	2014	All that indicate that higer values of urine NGAL are followed by higher percentage difference of serume creatinine and creatinine clearence.	Creatinine	120-130	lipocalin 2	Homo sapiens	45-49
24851612-12	2014	By using of automated urine NGAL test detection of acute kidney injure is posible 24-48 hours earlier comparing with actual results acquired by determination of serum creatinine concentration.	Creatinine	167-177	lipocalin 2	Homo sapiens	28-32
24398889-3	2014	METHODS: Serum homoarginine (mean: 2.41 +- 1.05 micromol/L), cystatin C and creatinine-based estimated GFR (eGFR, mean: 86.2 +- 23.0 mL/min per 1.73 m(2)) were measured in 3037 patients (mean age: 62.8 +- 10.6 years; 31.5% women) who were referred to coronary angiography.	Creatinine	76-86	Rap guanine nucleotide exchange factor 5	Homo sapiens	103-106
24748192-9	2014	CONCLUSION: The serum GDF15 level may reflect the tumor burden in the MM patients, which increases obviously, is related with ISS, positively correlated with serum M protein level, beta2- microglobulin level, serum creatinine and negatively with hemoglobin concentration and platelet count.	Creatinine	215-225	growth differentiation factor 15	Homo sapiens	22-27
24134783-6	2014	This CD163 increase correlated with 4-month creatinine levels (r = 0 4394, P = 0 04).	Creatinine	44-54	CD163 molecule	Homo sapiens	5-10
24134783-8	2014	CD14(+) CD16(-) monocytes increased at 4 months and correlated positively with creatinine levels at 12 and 24 months (r = 0 6348, P = 0 002 and r = 0 467, P = 0 028, respectively) and negatively with Modification of Diet in Renal Disease (MDRD) at 12 months (r = 0 6056, P = 0 003).	Creatinine	79-89	Fc gamma receptor IIIa	Homo sapiens	8-12
24134783-9	2014	At 4 months, IL-10 decreased significantly (P = 0 008) and correlated positively with creatinine at 2 years (r = 0 68, P = 0 010) and with CD14(+) CD16(-) monocytes at 4 months (r = 0 732, P = 0 004).	Creatinine	86-96	interleukin 10	Homo sapiens	13-18
24396416-6	2014	The quantification results were obtained by correcting for creatinine expression and showed that urinary VDBP levels were significantly elevated in the patients of the DN1 and DN2 groups compared with those of the DM group and normal controls (1,011.33+-325.30 and 1,406.34+-239.66 compared with 466.54+-213.63 and 125.48+-98.27 ng/mg, respectively) (P&lt;0.001).	Creatinine	59-69	GC vitamin D binding protein	Homo sapiens	105-109
23982767-12	2014	CONCLUSIONS: Urinary BDNF/Cr levels are elevated in women with OAB and are significantly associated with symptom severity.	Creatinine	26-28	brain derived neurotrophic factor	Homo sapiens	21-25
24334166-0	2014	Urinary BDNF-to-creatinine ratio is associated with aerobic fitness.	Creatinine	16-26	brain derived neurotrophic factor	Homo sapiens	8-12
24416268-6	2014	There was a significant correlation between the degree of IF and the RBP/creatinine (creat) ratio (R2: 0.11, p&lt;0.0001).	Creatinine	73-83	retinol binding protein 4	Homo sapiens	69-72
24074822-12	2014	CONCLUSIONS: The CKD-EPI creatinine equation is more accurate and precise than the MDRD Study equation in estimating GFR in a South Asian population in Karachi.	Creatinine	25-35	Rap guanine nucleotide exchange factor 5	Homo sapiens	117-120
24226519-5	2014	Treatment in diet with the SGLT2-I for 3 wk maintained 1.5- to 2-fold higher urine glucose/creatinine ratios in Sglt1-/- vs. WT mice, associated with a temporarily greater reduction in blood glucose in Sglt1-/- vs. WT after 24 h (-33 vs. -11%).	Creatinine	91-101	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	27-32
24492366-6	2014	The apparent elimination clearance was significantly related to creatinine clearance (CLCR), reflecting renal function.	Creatinine	64-74	chymotrypsin C	Homo sapiens	86-90
25276429-0	2014	Serum prolidase activity and oxidative stress in diabetic nephropathy and end stage renal disease: a correlative study with glucose and creatinine.	Creatinine	136-146	peptidase D	Homo sapiens	6-15
25551967-6	2014	In preeclamptic group, a statistically meaningful correlation was found between level of NGAL and body mass index (BMI) of sampling time, creatinine and NGAL, total protein and NO, and albumin and NO.	Creatinine	138-148	lipocalin 2	Homo sapiens	89-93
25551967-7	2014	CONCLUSIONS: Serum NGAL levels, correlated with serum creatinine levels in this study, may be the early marker of renal damage which may develop mainly due to inflammation and endothelial damage.	Creatinine	54-64	lipocalin 2	Homo sapiens	19-23
24507048-11	2014	WC, creatinine, and uric acid were positively correlated with FGF-23, whereas albumin showed negative correlation.	Creatinine	4-14	fibroblast growth factor 23	Homo sapiens	62-68
24507048-12	2014	On multivariate analysis only creatinine and uric acid were determinants of FGF-23.	Creatinine	30-40	fibroblast growth factor 23	Homo sapiens	76-82
24655954-6	2014	Interestingly, the Endocan &gt;= 643.19 pg/mL group had higher creatinine (Cr; 1.2 +- 0.4 vs 1.6 +- 1.1 mg/dL; P = .029) and lower estimated glomerular filtration rate (eGFR; 67.8 +- 23.8 mL/min vs 54.4 +- 22.0; P = .006) than the Endocan &lt;643.19 pg/mL group after 3 months of follow-up, respectively.	Creatinine	63-73	endothelial cell specific molecule 1	Homo sapiens	19-26
24092386-5	2013	RESULTS: Survival in the CT-1-treated group was higher than in the untreated group and prevented IRI-induced reduction in the glomerular filtration rate, as shown by blunted increases in creatinine and urea plasma levels and less severe decrease in creatinine clearance.	Creatinine	187-197	cardiotrophin 1	Rattus norvegicus	25-29
24092386-5	2013	RESULTS: Survival in the CT-1-treated group was higher than in the untreated group and prevented IRI-induced reduction in the glomerular filtration rate, as shown by blunted increases in creatinine and urea plasma levels and less severe decrease in creatinine clearance.	Creatinine	249-259	cardiotrophin 1	Rattus norvegicus	25-29
24135202-7	2013	In AQP4 KO mice elevated creatinine levels were further increased by isoproterenol compared to AQP4 KO alone.	Creatinine	25-35	aquaporin 4	Mus musculus	3-7
23890403-9	2013	Preconditional activation of GLP-1R significantly improved the serum creatinine levels compared with vehicle (P &lt; 0.05).	Creatinine	69-79	glucagon-like peptide 1 receptor	Rattus norvegicus	29-35
24215663-14	2013	CONCLUSIONS: Results show the distinct features of plasma NGAL in AKI superimposed on CKD after cardiac surgery: 1) increased preoperative plasma NGAL is an independent risk factor for post-cardiac surgery AKI; 2) plasma NGAL showed an earlier peak than serum creatinine did, indicating that plasma NGAL can predict the recovery of AKI earlier; 3) different cutoff values of post-operative plasma NGAL are necessary to detect AKI superimposed on CKD distinctly from de novo AKI.	Creatinine	260-270	lipocalin 2	Homo sapiens	58-62
23649842-5	2013	The aim of this study was to evaluate Oat5 renal expression and its urinary excretion in rats exposed to different doses of cisplatin, in comparison with traditional markers of renal injury, like renal histology, creatinine and urea plasma levels, creatinine clearance, protein and glucose urinary levels and urinary alkaline phosphatase (AP) activity.	Creatinine	248-258	solute carrier family 22, member 24	Rattus norvegicus	38-42
23564583-8	2013	In multivariable survival models, we show that HSP70 level above the median is an age-, sex-, body mass index-, creatinine-, and NT-proBNP-independent predictor of 5-year mortality in HF.	Creatinine	112-122	heat shock protein family A (Hsp70) member 4	Homo sapiens	47-52
24718463-10	2013	Lp-PLA2 correlated significantly (p &lt; 0,05 for all) with non-HDL cholesterol, LDL, HDL, creatinine, waist circumference, body mass index and Framingham risk score.	Creatinine	91-101	phospholipase A2 group VII	Homo sapiens	0-7
24004413-2	2013	Moreover, several observational studies have demonstrated an association of a higher risk of death with higher serum creatinine-based estimates of GFR at the time of initiation of dialysis.	Creatinine	117-127	Rap guanine nucleotide exchange factor 5	Homo sapiens	147-150
24099047-9	2013	RBP4 was positively correlated with creatinine and body mass index, and negatively correlated with C-reactive protein and Global Initiative for Chronic Obstructive Lung Disease stage.	Creatinine	36-46	retinol binding protein 4	Homo sapiens	0-4
23623668-13	2013	Using multivariate logistic regression, we found that heart rate on presentation, the presence of angina pectoris, left ventricular ejection fraction, serum creatinine, and hemoglobin independently predicted elevated cTnI level.	Creatinine	157-167	troponin I3, cardiac type	Homo sapiens	217-221
24124387-11	2013	NGAL was found to be significantly correlated with creatinine in the cases with the value of the correlation coefficient being 0.4.	Creatinine	51-61	lipocalin 2	Homo sapiens	0-4
23795812-9	2013	Log FGF23 values were also shown by multivariate regression to significantly predict SYNTAX Score (p = 0.0137) after controlling for gender, creatinine, cholesterol, and log high-sensitivity C-reactive protein.	Creatinine	141-151	fibroblast growth factor 23	Homo sapiens	4-9
21655928-6	2013	The levels of HTNV-specific CD8(+) T lymphocytes in PBMC of patients with HFRS were negatively correlated with the levels of blood urea nitrogen and creatinine in plasma.	Creatinine	149-159	CD8a molecule	Homo sapiens	28-31
23831944-5	2013	NQO1-/- mice showed increased blood urea nitrogen and creatinine levels, tubular damage, oxidative stress, and apoptosis.	Creatinine	54-64	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-4
23876752-8	2013	As a consequence of non-renal determinants of serum creatinine, this equation has been shown to overestimate true GFR in elderly and hospitalized patients.	Creatinine	52-62	Rap guanine nucleotide exchange factor 5	Homo sapiens	114-117
23704286-0	2013	Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely.	Creatinine	14-24	Rap guanine nucleotide exchange factor 5	Homo sapiens	64-67
23704286-0	2013	Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely.	Creatinine	84-94	Rap guanine nucleotide exchange factor 5	Homo sapiens	64-67
23894776-8	2013	The activity of urinary HEXA and HEX B has been calculated per 1 mg of creatinine.	Creatinine	71-81	hexosaminidase subunit beta	Homo sapiens	33-38
23132334-8	2013	DTG does inhibit the renal OCT2 (IC(50) = 1.9 muM) transporter, which provides a mechanistic basis for the mild increases in serum creatinine observed in clinical studies.	Creatinine	131-141	POU class 2 homeobox 2	Homo sapiens	27-31
23374511-11	2013	There was a positive correlation of 4 h urine NGAL and serum delta creatinine at 48 h, which was statistically significant (rs = 0.33, p = 0.001).	Creatinine	67-77	lipocalin 2	Homo sapiens	46-50
23374511-12	2013	CONCLUSION: The study demonstrated that levels of urine NGAL in patients suffering from AKI increased significantly at 4 h as compared to serum creatinine levels.	Creatinine	144-154	lipocalin 2	Homo sapiens	56-60
23291313-8	2013	TNF-alphaR1 gene deletion and infliximab administration prevented the increase of urea, creatinine, gammaGT, kidney AST levels, iNOS and COX-2 expression, NF-kappaB translocation, MPO activity and MDA levels.	Creatinine	88-98	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	0-11
24384771-7	2013	Serum NGAL in diabetic group was associated with serum creatinine, fibrinogen, urinary NGAL, cystatin C and inversely related to kidney function assessed with 4 equations.	Creatinine	55-65	lipocalin 2	Homo sapiens	6-10
23363891-9	2013	Significantly higher rates of decline in creatinine clearance were noted in patients with TNF-alpha (rs1800629) GA+AA than GG genotype (0.88 +- 1.83 vs. 0.36 +- 0.70, p = 0.03), and with IL-10 (rs1800896) AG+GG than AA genotype (1.28 +- 2.14 vs. 0.33 +- 0.90, p &lt; 0.001).	Creatinine	41-51	interleukin 10	Homo sapiens	187-192
23712081-10	2013	Plasma NGAL added value to an AKI diagnostic model comprising plasma creatinine, sepsis, age, and APACHE II score (integrated discrimination improvement: 0.073; 0.034-0.12).	Creatinine	69-79	lipocalin 2	Homo sapiens	7-11
23041245-0	2013	Day-to-day variation of urinary NGAL and rational for creatinine correction.	Creatinine	54-64	lipocalin 2	Homo sapiens	32-36
24133923-6	2013	CONCLUSIONS: Plasma neutrophil gelatinase-associated lipocalin is a potent tool in the diagnosis of chronic kidney diseases and is shown to have high correlation with serum creatinine and estimated glomerular filtration rate.	Creatinine	173-183	lipocalin 2	Homo sapiens	20-62
22974561-7	2012	RESULT: We found that plasma DHEA-S levels were negatively associated with age, and positively associated with dialysis duration and plasma creatinine, albumin, and phosphate levels in hemodialysis men.	Creatinine	140-150	sulfotransferase family 2A member 1	Homo sapiens	29-35
23190744-8	2012	Patients with positive cTnI had higher serum creatinine (192 mumol/l (38 to 550) vs 117 mumol/l (46 to 929), P &lt; 0.001), arterial lactate (0.25, P &lt; 0.001) and a lower pH (-0.21, P = 0.002).	Creatinine	45-55	troponin I3, cardiac type	Homo sapiens	23-27
22943581-8	2012	Serum and urinary NGAL on the first day post-transplantation were higher in recipients with slow reduction in serum creatinine (urinary NGAL at the first day: 197 +- 153 [s.e.m.]	Creatinine	116-126	lipocalin 2	Homo sapiens	18-22
22943581-11	2012	The cutoff point of serum NGAL at the first day after transplantation for prediction of slow creatinine reduction was 174 ng/mL with a sensitivity of 100% and specificity of 95.5%.	Creatinine	93-103	lipocalin 2	Homo sapiens	26-30
22683759-3	2012	The level of urinary Hg (UHg-C) was calculated as mug/g creatinine.	Creatinine	56-66	small nucleolar RNA host gene 1	Homo sapiens	25-28
22683759-6	2012	The lowest observed effect was seen at UHg-C levels above 1.452 mug/g creatinine, which is lower than previously reported.	Creatinine	70-80	small nucleolar RNA host gene 1	Homo sapiens	39-42
21111635-7	2012	Deterioration of mRS was significantly correlated with high serum pentosidine (P = .003) and creatinine (P = .02).	Creatinine	93-103	sterile alpha motif domain containing 11	Mus musculus	17-20
22246211-6	2012	The relationship between total cefoxitin clearance (CL) and creatinine clearance (CL(CR)) was best described using a nonlinear model [CL = 11.5 x (CL(CR)/77)(0.52)].	Creatinine	60-70	chymotrypsin C	Homo sapiens	41-51
22246211-6	2012	The relationship between total cefoxitin clearance (CL) and creatinine clearance (CL(CR)) was best described using a nonlinear model [CL = 11.5 x (CL(CR)/77)(0.52)].	Creatinine	60-70	chymotrypsin C	Homo sapiens	71-88
22357179-7	2012	Both sC5b-9 and MASP-2 were correlated to age and creatinine clearance, while MASP-2 was also correlated to BMI.	Creatinine	50-60	MBL associated serine protease 2	Homo sapiens	16-22
23723578-1	2012	PURPOSE OF THE STUDY: The purpose of the present study is to find out the correlation between the glomerular filtration rate (GFR by Gates gamma camera method) and serum creatinine clearance (SCrCl by Cockcroft and Gault"s method) within +- 3 weeks" time difference.	Creatinine	170-180	Rap guanine nucleotide exchange factor 5	Homo sapiens	126-129
22282588-6	2012	Compared with wild-type sFlt-1 mice, eNOS-deficient sFlt-1 mice also showed markedly higher urinary albumin excretion (467+-74 versus 174+-23 mug/d), lower creatinine clearance (126+-29 versus 452+-63 mul/min), and more severe endotheliosis.	Creatinine	156-166	FMS-like tyrosine kinase 1	Mus musculus	52-58
21987536-7	2012	Cpn10 also suppressed lupus nephritis as evident from serum creatinine levels, albuminuria and the scores of disease activity and chronicity.	Creatinine	60-70	heat shock protein 1 (chaperonin 10)	Mus musculus	0-5
22325322-8	2012	In the Tx group NGAL concentrations were associated with serum creatinine (R = 0.51, p &lt; 0.0001), duration of end-stage renal failure (R = 0.41, p = 0.002) and leukocyte count (R = 0.29, p &lt; 0.026).	Creatinine	63-73	lipocalin 2	Homo sapiens	16-20
22325322-10	2012	CONCLUSIONS: Plasma NGAL is a novel marker of kidney function, which correlates to duration of end-stage renal failure (ESRD) and serum creatinine in uraemic patients awaiting kidney transplantation.	Creatinine	136-146	lipocalin 2	Homo sapiens	20-24
22158084-6	2012	ELISA quantification of urinary VDBP corrected for creatinine expression (VDBP-Cr) revealed that urinary VDBP-Cr was significantly greater in patients with endometriosis than in those without (111.96 +- 74.59 versus 69.90 +- 43.76 ng/mg Cr, P = 0.001).	Creatinine	51-61	GC vitamin D binding protein	Homo sapiens	74-78
22158084-6	2012	ELISA quantification of urinary VDBP corrected for creatinine expression (VDBP-Cr) revealed that urinary VDBP-Cr was significantly greater in patients with endometriosis than in those without (111.96 +- 74.59 versus 69.90 +- 43.76 ng/mg Cr, P = 0.001).	Creatinine	51-61	GC vitamin D binding protein	Homo sapiens	74-78
22119342-5	2012	PATIENTS AND METHODS: FGE was calculated using the MDRD and CKD-EPI equation in 20000 subjects based on the data for gender, age and serum creatinine.	Creatinine	139-149	sulfatase modifying factor 1	Homo sapiens	22-25
21971116-9	2012	Univariate regression analysis showed that serum chemerin concentration was positively correlated with serum creatinine and phosphate concentrations and negatively correlated with eGFR.	Creatinine	109-119	retinoic acid receptor responder 2	Homo sapiens	49-57
22627273-14	2012	The magnitude of rise in NGAL is positively associated with the baseline value and is analogous to the time course of Cr in blood after contrast exposure.	Creatinine	118-120	lipocalin 2	Homo sapiens	25-29
22876902-8	2012	NGAL can be easily measured in urine by an automated analytical method, allowing its clinical use in emergency likewise creatinine.	Creatinine	120-130	lipocalin 2	Homo sapiens	0-4
22500106-6	2012	Furthermore, NGAL excretion in the SLE-renal group was correlated with serum creatinine levels and creatinine clearance, but not with the SLE Disease Activity Index score.	Creatinine	77-87	lipocalin 2	Homo sapiens	13-17
22500106-6	2012	Furthermore, NGAL excretion in the SLE-renal group was correlated with serum creatinine levels and creatinine clearance, but not with the SLE Disease Activity Index score.	Creatinine	99-109	lipocalin 2	Homo sapiens	13-17
22031097-5	2012	Serum levels of FGF23 increased in the earliest stages of renal damage, before elevations in blood urea nitrogen (BUN) and creatinine.	Creatinine	123-133	fibroblast growth factor 23	Mus musculus	16-21
22031097-9	2012	Our findings suggest elevations of FGF23 in CKD to be an early marker of renal injury that increases before BUN and serum creatinine.	Creatinine	122-132	fibroblast growth factor 23	Mus musculus	35-40
22034506-6	2011	With respect to biochemical parameters, higher parathyroid hormone, phosphate, uric acid, and triglyceride levels all were associated independently with higher FGF23 in models adjusted for age, creatinine, and other factors.	Creatinine	194-204	fibroblast growth factor 23	Homo sapiens	160-165
21949094-6	2011	In contrast, administration of recombinant IL-33 (rIL-33) exacerbated cisplatin-induced AKI, measured by an increase in CD4 T cell infiltration, serum creatinine, ATN, and apoptosis; this did not occur in CD4-deficient mice, suggesting that CD4 T cells mediate the injurious effect of IL-33.	Creatinine	151-161	interleukin 33	Mus musculus	51-56
26511274-10	2016	In acute HF, higher plasma KIM-1 levels were associated with higher creatinine, lower albumin, and presence of diabetes.	Creatinine	68-78	hepatitis A virus cellular receptor 1	Homo sapiens	27-32
27233360-11	2016	Increased level of urea, creatinine, bilirubin, blood urea nitrogen whereas decreased concentration of proteins in serum of CCl4 treated animals were restored towards the normal level with co-administration of ASM.	Creatinine	25-35	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	210-213
27091114-8	2016	Kidney function, as assessed by serum creatinine and serum urea, correlated positively with the number of total CD68+, M2a-like and M2c-like macrophages in the tubulointerstitium.	Creatinine	38-48	CD68 molecule	Homo sapiens	112-116
27001276-6	2016	Adiponectin concentrations strongly correlated with serum 25-hydroxycholecalciferol (r = 0.815; P &lt; .001) and urinary creatinine concentrations (r = 0.818; P &lt; .001) and inversely correlated with proteinuria (r = -0.583; P = .02).	Creatinine	121-131	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	0-11
26559600-13	2016	CONCLUSIONS: BCM is strongly associated with biochemical determinants of muscle mass (serum creatinine, insulin-like growth factor 1) and muscle function (HGS) in patients treated with HD, with CKD Stage 4 to 5 and in individuals without kidney disease.	Creatinine	92-102	TNF receptor superfamily member 17	Homo sapiens	13-16
26962815-7	2016	Uromodulin was correlated with all biomarkers/eGFR in univariate analysis (eGFR: r = 0.80, creatinine: r = -0.76, BUN: r = -0.72, and cystatin C: r = -0.79).	Creatinine	91-101	uromodulin	Homo sapiens	0-10
21716260-0	2011	Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate.	Creatinine	57-67	vitamin D receptor	Homo sapiens	11-29
21716260-1	2011	Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function.	Creatinine	71-81	vitamin D receptor	Homo sapiens	0-18
21716260-2	2011	Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clearance.	Creatinine	69-79	vitamin D receptor	Homo sapiens	30-48
21716260-2	2011	Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clearance.	Creatinine	81-91	vitamin D receptor	Homo sapiens	30-48
21716260-9	2011	Thus, short-term vitamin D receptor activation increases creatinine generation and serum creatinine, but it does not influence the glomerular filtration rate.	Creatinine	57-67	vitamin D receptor	Homo sapiens	17-35
21716260-9	2011	Thus, short-term vitamin D receptor activation increases creatinine generation and serum creatinine, but it does not influence the glomerular filtration rate.	Creatinine	89-99	vitamin D receptor	Homo sapiens	17-35
22042029-0	2011	Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration.	Creatinine	61-71	vitamin D receptor	Homo sapiens	22-40
22042029-0	2011	Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration.	Creatinine	73-83	vitamin D receptor	Homo sapiens	22-40
22042029-5	2011	These observations may be explainable by an effect of vitamin D receptor activation on creatinine metabolism.	Creatinine	87-97	vitamin D receptor	Homo sapiens	54-72
26530874-0	2016	Creatinine Versus Cystatin C for Estimating GFR in Patients With Liver Cirrhosis.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	44-47
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	microRNA 199a-2	Homo sapiens	120-131
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	120-123
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	lipocalin 2	Homo sapiens	210-214
21467131-12	2011	Univariate analysis showed that baseline serum creatinine and urinary excretion of total protein, alpha(1)m, beta(2)m, immunoglobulin G, KIM-1 and NGAL were significantly associated with ESRD.	Creatinine	47-57	hepatitis A virus cellular receptor 1	Homo sapiens	137-142
21467131-12	2011	Univariate analysis showed that baseline serum creatinine and urinary excretion of total protein, alpha(1)m, beta(2)m, immunoglobulin G, KIM-1 and NGAL were significantly associated with ESRD.	Creatinine	47-57	lipocalin 2	Homo sapiens	147-151
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
21924344-11	2011	In type 1 diabetic rats, ST-3 supplement for three weeks caused significant reduction in fasting blood glucose, total cholesterol, triglyceride, urea nitrogen, creatinine and liver mass, along with significantly inhibiting the decline of insulin level compared to diabetic control (p&lt;0.05 or p&lt;0.01).	Creatinine	160-170	matrix metallopeptidase 11	Rattus norvegicus	25-29
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	microRNA 199a-2	Homo sapiens	302-313
26569364-5	2016	The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p.	Creatinine	16-26	membrane associated ring-CH-type finger 8	Homo sapiens	133-136
26683887-6	2016	Uromodulin excretion was 25 (11-42) mg/g creatinine.	Creatinine	41-51	uromodulin	Homo sapiens	0-10
27064621-12	2016	In particular, patients with CFH mutations had a worse renal function than those with membrane cofactor protein mutations, a higher level of serum creatinine at the disease onset and a higher percentage of renal insufficiency during follow-up.	Creatinine	147-157	complement factor H	Homo sapiens	29-32
21876477-5	2011	RESULTS: The ratio of urinary CXCL10 to creatinine (CXCL10: Cr) was found to distinguish borderline, subclinical and clinical tubulitis from normal histology, and IFTA.	Creatinine	40-50	C-X-C motif chemokine ligand 10	Homo sapiens	30-36
21876477-5	2011	RESULTS: The ratio of urinary CXCL10 to creatinine (CXCL10: Cr) was found to distinguish borderline, subclinical and clinical tubulitis from normal histology, and IFTA.	Creatinine	40-50	C-X-C motif chemokine ligand 10	Homo sapiens	52-58
21970770-15	2011	NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN: Neutrophil gelatinase-associated lipocalin (NGAL) is expressed by renal tubular epithelium, and a rise in urinary concentrations may provide an indicator of acute renal injury caused by any one of a broad range of provoking factors that is detectable before a rise in serum creatinine concentrations.	Creatinine	318-328	lipocalin 2	Homo sapiens	0-42
21970770-15	2011	NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN: Neutrophil gelatinase-associated lipocalin (NGAL) is expressed by renal tubular epithelium, and a rise in urinary concentrations may provide an indicator of acute renal injury caused by any one of a broad range of provoking factors that is detectable before a rise in serum creatinine concentrations.	Creatinine	318-328	lipocalin 2	Homo sapiens	44-86
21970770-15	2011	NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN: Neutrophil gelatinase-associated lipocalin (NGAL) is expressed by renal tubular epithelium, and a rise in urinary concentrations may provide an indicator of acute renal injury caused by any one of a broad range of provoking factors that is detectable before a rise in serum creatinine concentrations.	Creatinine	318-328	lipocalin 2	Homo sapiens	88-92
26745339-7	2016	Although NGAL was significantly related to e-GFR, creatinine, urea and albumin in CKD-patients (p &lt; 0.001) and not in the other NCD patients (p &gt; 0.05), only serum creatinine predicted NGAL levels in CKD-patients (p &lt; 0.001).	Creatinine	170-180	lipocalin 2	Homo sapiens	9-13
26745339-8	2016	CONCLUSION: NGAL level is best associated with serum creatinine only in patients with CKD and NGAL measurement may not be cost effective as a routine kidney function test in NCD patients in under-resourced economies.	Creatinine	53-63	lipocalin 2	Homo sapiens	12-16
26247791-9	2015	For CD31(+)CD45(-)CD146(-) counts, representing large platelets, an inverse relationship with strut coverage was identified by a multivariable regression model adjusting for age, sex, diabetes mellitus, NYHA and CCS class, CRP, serum triglycerides, glucose and creatinine (beta=-9.42, p=0.006).	Creatinine	261-271	melanoma cell adhesion molecule	Homo sapiens	18-23
21970770-19	2011	Urinary KIM-1 expression may be detected after exposure to a variety of nephrotoxic agents, even when serum creatinine concentrations do not increase, and this has been accepted by regulatory authorities as a sensitive biomarker of acute kidney injury during early drug development.	Creatinine	108-118	hepatitis A virus cellular receptor 1	Homo sapiens	8-13
26350438-11	2015	CONCLUSIONS: Elevated urinary KIM-1/Cr may be associated with a higher risk of incident ESRD, but it does not add to risk prediction after accounting for traditional markers of kidney function in this population.	Creatinine	36-38	hepatitis A virus cellular receptor 1	Homo sapiens	30-35
21839662-6	2011	In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (beta=-0.12, p=0.036 and beta=-0.22, p&lt;0.001, respectively).	Creatinine	87-97	sulfotransferase family 2A member 1	Homo sapiens	146-152
21996181-10	2011	Their expressions positively correlated with serum creatinine concentrations after 6 months after transplantation: LCN2 (r=.65, P&lt;.0001), HAVCR1 (r=.44, P=.006).	Creatinine	51-61	lipocalin 2	Homo sapiens	115-119
21996181-10	2011	Their expressions positively correlated with serum creatinine concentrations after 6 months after transplantation: LCN2 (r=.65, P&lt;.0001), HAVCR1 (r=.44, P=.006).	Creatinine	51-61	hepatitis A virus cellular receptor 1	Homo sapiens	141-147
21996225-5	2011	Upon univariate analysis, urinary KIM-1 strongly correlated with serum creatinine (r=.54) and eGFR (r=.66) but only weakly with other parameters.	Creatinine	71-81	hepatitis A virus cellular receptor 1	Homo sapiens	34-39
21885463-2	2011	An increase in the level of neutrophil gelatinase-associated lipocalin is a good predictor of acute kidney injury and is associated with an increase in the serum level of creatinine.	Creatinine	171-181	lipocalin 2	Homo sapiens	28-70
21885463-5	2011	In this case, measuring the level of neutrophil gelatinase-associated lipocalin enabled early diagnosis of acute kidney injury and anticipation of the changes in levels of conventional markers such as creatinine.	Creatinine	201-211	lipocalin 2	Homo sapiens	37-79
21333373-9	2011	Serum mesothelin increased significantly with increasing serum creatinine (p&lt;0.0001), and worsening stage of CKD (p&lt;0.0001).	Creatinine	63-73	mesothelin	Homo sapiens	6-16
21333373-10	2011	A significant correlation between urine mesothelin to creatinine ratio and serum mesothelin concentration was detected (p=0.002).	Creatinine	54-64	mesothelin	Homo sapiens	40-50
21333373-10	2011	A significant correlation between urine mesothelin to creatinine ratio and serum mesothelin concentration was detected (p=0.002).	Creatinine	54-64	mesothelin	Homo sapiens	81-91
21477622-6	2011	Furthermore, chemerin serum levels positively correlated with blood pressure, creatinine, free fatty acids, cholesterol, triglycerides (TG), leptin, adiponectin, and C-reactive protein in univariate analyses.	Creatinine	78-88	retinoic acid receptor responder 2	Homo sapiens	13-21
21511111-2	2011	BACKGROUND: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function.	Creatinine	119-129	lipocalin 2	Homo sapiens	12-54
20935115-12	2011	However, NGAL adds significant accuracy to this prediction in combination with eGFR alone or with other clinical parameters and has an interesting predictive value in patients with normal serum creatinine.	Creatinine	194-204	lipocalin 2	Homo sapiens	9-13
21352605-7	2011	CRT, taurine transporter (TauT/SLC6A6) and organic cation transporter (OCT3/SLC22A3) expressed at the BCSFB are involved in guanidinoacetic acid or creatinine efflux transport from CSF.	Creatinine	148-158	solute carrier family 22 member 3	Homo sapiens	71-75
21352605-7	2011	CRT, taurine transporter (TauT/SLC6A6) and organic cation transporter (OCT3/SLC22A3) expressed at the BCSFB are involved in guanidinoacetic acid or creatinine efflux transport from CSF.	Creatinine	148-158	solute carrier family 22 member 3	Homo sapiens	76-83
21235779-4	2011	METHODS: In the Heart and Soul Study, the UMOD snp (12917707) was genotyped in 879 individuals with baseline creatinine clearance (CrCl) measured from a 24-hour urine collection.	Creatinine	109-119	uromodulin	Homo sapiens	42-46
21912102-5	2011	RESULTS: In renal cancer patients, median NGAL excretion was 0.52 (1st to 3rd quartiles: 0.28-0.82) ng/mg urinary creatinine (U(Cr)) before nephrectomy compared to 0.15 (0.04-0.31) ng/mg U(Cr) in controls (p &lt; 0.001), and there was a modest decrease of 30% after nephrectomy (p &lt; 0.008).	Creatinine	114-124	lipocalin 2	Homo sapiens	42-46
22593994-10	2011	RESULTS AND CONCLUSIONS: It was found that the GG genotype of the rs5498 polymorphisms of the ICAM1 gene is a significant risk factor of acute rejection and is correlated with elevated concentrations of creatinine in allogenic renal graft recipients.	Creatinine	203-213	intercellular adhesion molecule 1	Homo sapiens	94-99
20861824-5	2011	Patients who developed DGF had a significantly slower decrease in urinary NGAL compared with those without DGF, such that day 1 NGAL predicted DGF (area under the curve (AUC) 0.75) and predicted DGF in 15 of 112 cases with day 1 urine output over 1 l (AUC 0.70) and in 19 of 86 cases with a day 1 decrease in creatinine over 50 mumol/l (AUC 0.74).	Creatinine	309-319	lipocalin 2	Homo sapiens	74-78
20861824-5	2011	Patients who developed DGF had a significantly slower decrease in urinary NGAL compared with those without DGF, such that day 1 NGAL predicted DGF (area under the curve (AUC) 0.75) and predicted DGF in 15 of 112 cases with day 1 urine output over 1 l (AUC 0.70) and in 19 of 86 cases with a day 1 decrease in creatinine over 50 mumol/l (AUC 0.74).	Creatinine	309-319	lipocalin 2	Homo sapiens	128-132
26180236-7	2015	LPD in rats fed high phosphate induced malnutrition (decreases in body weight, food intake, serum albumin and fetuin-A levels, and urinary creatinine excretion) and systemic inflammation (increases in serum tumor necrosis factor-alpha and urinary oxidative stress marker).	Creatinine	139-149	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	0-3
20463654-6	2010	Infusion of CD4+CD25+Treg cells into wild-type Balb/c mice reduced serum blood urea nitrogen and creatinine levels equivalent to those in nu/nu mice and extended their survival time after cisplatin injection.	Creatinine	97-107	CD4 antigen	Mus musculus	12-15
26543745-6	2015	CXCL1 concentration level was normalized using urinary protein and urinary creatinine concentrations.	Creatinine	75-85	C-X-C motif chemokine ligand 1	Homo sapiens	0-5
20707671-11	2010	Also, the carboxy-terminal FGF-23 assay appeared to correlate better with worsening of kidney function as assessed by plasma creatinine and calculated estimated glomerular filtration rate (eGFR).	Creatinine	125-135	fibroblast growth factor 23	Homo sapiens	27-33
21150136-9	2010	Urine LCN2 levels which were normalized to urine creatinine concentration (urine LCN2-to-creatinine ratio; ULCR) were higher in F2-F4 patients compared to F0-F1 patients.	Creatinine	49-59	lipocalin 2	Homo sapiens	6-10
21150136-9	2010	Urine LCN2 levels which were normalized to urine creatinine concentration (urine LCN2-to-creatinine ratio; ULCR) were higher in F2-F4 patients compared to F0-F1 patients.	Creatinine	89-99	lipocalin 2	Homo sapiens	6-10
21168598-12	2010	Upon univariate analysis urinary KIM-1 strongly correlated with serum creatinine (r = .64) and eGFR (r = -.71), and only weakly with other parameters.	Creatinine	70-80	hepatitis A virus cellular receptor 1	Homo sapiens	33-38
20435938-3	2010	METHODS: In a retrospective observational study, we examined the value of plasma NGAL measured after CPB for predicting the risk of developing AKI (defined as a &gt; or = 50% increase in serum creatinine from preoperative levels) in 879 patients after CABG surgery using multivariable logistic regression.	Creatinine	193-203	lipocalin 2	Homo sapiens	81-85
20134257-5	2009	The urinary ICAM-1/urinary Cr ratio of diabetics had a positive correlation with FBG (r=0.51, p&lt;0.01), P2hBG (r=0.496, p&lt;0.01), and HbA1c (r=0.478, p&lt;0.05), respectively.	Creatinine	27-29	intercellular adhesion molecule 1	Homo sapiens	12-18
19833901-3	2009	Estimated GFR based on serum creatinine is now widely reported by clinical laboratories, and in most circumstances, estimated GFR is sufficient for clinical decision making.	Creatinine	29-39	Rap guanine nucleotide exchange factor 5	Homo sapiens	10-13
19833901-6	2009	Endogenous creatinine clearance is the most common method used to measure GFR in clinical practice but may be difficult to obtain or fraught with error.	Creatinine	11-21	Rap guanine nucleotide exchange factor 5	Homo sapiens	74-77
19757187-9	2009	The scores of oblique mental component summary (MCSc) were worse for females, patients with a lower income, unemployed and patients with a higher serum creatinine.	Creatinine	152-162	solute carrier family 25 member 25	Homo sapiens	48-52
26543745-8	2015	Mean urinary concentrations of CXCL1 were significantly higher in subjects with BCa compared to subjects without BCa (179.8 +- 371.7 pg/mg of creatinine vs. 28.2 +- 71.9 pg/mg, respectively p = 0.0009).	Creatinine	142-152	C-X-C motif chemokine ligand 1	Homo sapiens	31-36
25948679-4	2015	The highest tertile of plasma MR-proADM (a surrogate for ADM) concentration at baseline was associated with the risk of renal outcomes (doubling of plasma creatinine concentration and/or progression to end-stage renal disease) during follow-up in both cohorts.	Creatinine	155-165	adrenomedullin	Homo sapiens	36-39
25993317-4	2015	PLA2-injected mice showed reduced levels of serum creatinine, blood urea nitrogen, renal tissue damage, and pro-inflammatory cytokine production upon cisplatin administration.	Creatinine	50-60	phospholipase A2, group IB, pancreas	Mus musculus	0-4
25281008-1	2015	BACKGROUND: We reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine.	Creatinine	158-168	Rap guanine nucleotide exchange factor 5	Homo sapiens	130-133
25407760-0	2015	Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general population.	Creatinine	73-83	Rap guanine nucleotide exchange factor 5	Homo sapiens	48-51
19708926-5	2009	Serum NGAL in univariate analysis was strongly correlated with serum creatinine (r = 0.78).	Creatinine	69-79	lipocalin 2	Homo sapiens	6-10
19950779-7	2009	In patients with colon adenocarcinoma mucinosum, the higher activity of HEX was revealed in blood serum compared to healthy people, and the significantly higher activity of HEX and HEX B expressed as pKat/mg of creatinine, was found in urine.	Creatinine	211-221	hexosaminidase subunit beta	Homo sapiens	181-186
19950779-8	2009	We observe a significant increase in the activity of HEX, HEX A and HEX B expressed in pKat/mg of creatinine was found in urine of patients bearing tumor of diameter 6.0-7.0 cm in comparison to patients with tumor of diameter 4.0-5.0 cm.	Creatinine	98-108	hexosaminidase subunit beta	Homo sapiens	68-73
19426682-3	2009	Guanidine, creatinine and aminoguanidine more markedly inhibited the uptake of [(14)C]tetraethylammonium (TEA) by hOCT2 than by hOCT1.	Creatinine	11-21	POU class 2 homeobox 2	Homo sapiens	114-119
18931100-3	2009	RESULTS: Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P &lt; 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P &lt; 0.05, respectively).	Creatinine	69-79	fatty acid binding protein 5	Homo sapiens	26-32
19122345-8	2009	Serum RBP4 levels had a positive correlation with serum creatinine levels(r = 0.377, p&lt;0.001), and a negative correlation with 1/creatinine (r = -0.420, p&lt;0.001).	Creatinine	56-66	retinol binding protein 4	Homo sapiens	6-10
19122345-8	2009	Serum RBP4 levels had a positive correlation with serum creatinine levels(r = 0.377, p&lt;0.001), and a negative correlation with 1/creatinine (r = -0.420, p&lt;0.001).	Creatinine	132-142	retinol binding protein 4	Homo sapiens	6-10
20726326-12	2009	RAGE -374 A allele was associated with increased sRAGE levels, hypertension and increased creatinine concentration in diabetic patients.	Creatinine	90-100	advanced glycosylation end-product specific receptor	Homo sapiens	0-4
18796410-6	2009	A decreased expression in renal homogenates and apical membranes and an increase in urinary excretion of Oat5 and NaDC1 were observed in I60R60 rats, as well as alterations of other widely used parameters for renal dysfunction and injury (plasma creatinine, urinary AP activity, kidney weight, histological lesions).	Creatinine	246-256	solute carrier family 22, member 24	Rattus norvegicus	105-109
19287180-3	2009	The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of kidney function in adult patients with chronic heart failure and normal serum creatinine.	Creatinine	216-226	lipocalin 2	Homo sapiens	43-85
19287180-3	2009	The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of kidney function in adult patients with chronic heart failure and normal serum creatinine.	Creatinine	216-226	lipocalin 2	Homo sapiens	87-91
19287180-6	2009	Serum NGAL was related, in univariate analysis, to serum creatinine, urinary NGAL, hemoglobin, hematocrit, leukocyte count, eGFR, cystatin C.	Creatinine	57-67	lipocalin 2	Homo sapiens	6-10
19287180-7	2009	Urinary NGAL correlated with age, hemoglobin, hematocrit, serum creatinine, eGFR.	Creatinine	64-74	lipocalin 2	Homo sapiens	8-12
25407760-1	2015	BACKGROUND: Previous studies have shown that GFR estimated from serum creatinine (eGFRcr) is higher in smokers although the implications remain unclear.	Creatinine	70-80	Rap guanine nucleotide exchange factor 5	Homo sapiens	45-48
26321027-4	2015	RESULTS: Hypertensive participants had significantly higher urine FGF23/creatinine values than the reference group (8.65 vs 5.59 RU/mg creatinine, P=0.007).	Creatinine	135-145	fibroblast growth factor 23	Homo sapiens	66-71
26321027-6	2015	In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium.	Creatinine	38-48	fibroblast growth factor 23	Homo sapiens	32-37
26604626-9	2015	Further a strong positive correlation was observed between the duration of diabetes and the serum levels of CTnI and creatinine (r = 0.84, P &gt; 0.01) and (r = 0.72, P &gt; 0.01), respectively.	Creatinine	117-127	troponin I3, cardiac type	Homo sapiens	108-112
26193703-9	2015	Each doubling in parathyroid hormone, creatinine, and C-reactive protein was related to higher FGF23.	Creatinine	38-48	fibroblast growth factor 23	Homo sapiens	95-100
20068352-7	2009	NGAL correlated with age, residual renal function, hsCRP, IL-6, TNF-alpha, time on HD, ferritin, TSAT, creatinine, urea, urea reduction ratio, and Kt/V in hemodialyzed patients.	Creatinine	103-113	lipocalin 2	Homo sapiens	0-4
20068352-9	2009	NGAL correlated with hsCRP and creatinine in HDF patients.	Creatinine	31-41	lipocalin 2	Homo sapiens	0-4
18685143-9	2009	The mRNA expression of nephrin, erzin, podocin but not synaptopodin correlated with the degree of proteinuria and creatinine clearance.	Creatinine	114-124	NPHS1 adhesion molecule, nephrin	Homo sapiens	23-30
19690440-6	2009	Serum levels of sTNFR1 and sTNFR2 correlated with serum creatinine, while the surface expression of TNFR1 and TNFR2 on the granulocytes did not.	Creatinine	56-66	TNF receptor superfamily member 1B	Homo sapiens	28-33
18400816-7	2008	RESULTS: At 4 weeks, the mRNA expression of BMP-7 in PDE significantly correlated with peritoneal transport characteristics, including the dialysate-to-plasma creatinine ratio at 4 h (D/P4) (r = 0.422, P = 0.015) and mass transfer area coefficient (MTAC) of creatinine (r = 0.457, P = 0.008).	Creatinine	159-169	bone morphogenetic protein 7	Homo sapiens	44-49
18400816-7	2008	RESULTS: At 4 weeks, the mRNA expression of BMP-7 in PDE significantly correlated with peritoneal transport characteristics, including the dialysate-to-plasma creatinine ratio at 4 h (D/P4) (r = 0.422, P = 0.015) and mass transfer area coefficient (MTAC) of creatinine (r = 0.457, P = 0.008).	Creatinine	258-268	bone morphogenetic protein 7	Homo sapiens	44-49
18788398-4	2008	Urinalysis, especially urinary protein detection, and measurement of serum creatinine level (estimation of GFR) are the two major tests to detect CKD.	Creatinine	75-85	Rap guanine nucleotide exchange factor 5	Homo sapiens	107-110
18456280-9	2008	RESULTS: HO-1 preconditioning led to significantly lower serum creatinine and serum urea, as well as less histological damage and inducible nitric oxide synthase expression.	Creatinine	63-73	heme oxygenase 1	Rattus norvegicus	9-13
18216145-16	2008	Administration of recombinant netrin-1 significantly improved kidney function (blood urea nitrogen: 161 +/- 7 vs. 104 +/- 24 mg/dl, creatinine: 1.3 +/- 0.07 vs. 0.75 +/- 0.16 mg/dl, P &lt; 0.05 at 24 h) and reduced tubular damage and leukocyte infiltration in the outer medulla.	Creatinine	132-142	netrin 1	Homo sapiens	30-38
18234954-7	2008	Urinary netrin-1 levels increased markedly within 3 h of ischemia-reperfusion (40 +/- 14-fold, P &lt; 0.01 vs. baseline), reached a peak level at 6 h, and decreased thereafter, returning to near baseline by 72 h. Serum creatinine significantly increased only after 24 h of reperfusion.	Creatinine	219-229	netrin 1	Homo sapiens	8-16
18004294-6	2008	Inactivation of IL-16 by antibody therapy or IL-16 deficiency prevented ischemia-reperfusion injury as shown by reduced levels of serum creatinine or blood urea nitrogen compared to control mice.	Creatinine	136-146	interleukin 16	Mus musculus	16-21
18004294-6	2008	Inactivation of IL-16 by antibody therapy or IL-16 deficiency prevented ischemia-reperfusion injury as shown by reduced levels of serum creatinine or blood urea nitrogen compared to control mice.	Creatinine	136-146	interleukin 16	Mus musculus	45-50
25904762-0	2015	Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.	Creatinine	94-104	solute carrier family 22 member 7	Homo sapiens	20-47
17911094-1	2008	BACKGROUND: Urinary interleukin-18 (uIL-18) is an earlier acute kidney injury (AKI) biomarker than serum creatinine (SCr) in specific populations.	Creatinine	105-115	interleukin 18	Homo sapiens	20-34
25904762-0	2015	Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.	Creatinine	94-104	solute carrier family 22 member 7	Homo sapiens	49-56
25904762-1	2015	The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion of creatinine and its exact localization in the kidney are reportedly controversial.	Creatinine	95-105	solute carrier family 22 member 7	Homo sapiens	46-50
25904762-1	2015	The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion of creatinine and its exact localization in the kidney are reportedly controversial.	Creatinine	95-105	solute carrier family 22 member 7	Homo sapiens	52-59
25904762-2	2015	In the present investigation, the transport of creatinine was assessed in human embryonic kidney (HEK) cells that stably expressed human OAT2 (OAT2-HEK) and isolated human renal proximal tubule cells (HRPTCs).	Creatinine	47-57	solute carrier family 22 member 7	Homo sapiens	137-141
18661413-6	2008	Serum NGAL was related, in univariate analysis, to serum creatinine, urinary NGAL, hemoglobin, hematocrit, leukocyte count, eGFR, and cystatin C.	Creatinine	57-67	lipocalin 2	Homo sapiens	6-10
18661413-7	2008	Urinary NGAL correlated with age, hemoglobin, hematocrit, serum creatinine, and eGFR.	Creatinine	64-74	lipocalin 2	Homo sapiens	8-12
25904762-2	2015	In the present investigation, the transport of creatinine was assessed in human embryonic kidney (HEK) cells that stably expressed human OAT2 (OAT2-HEK) and isolated human renal proximal tubule cells (HRPTCs).	Creatinine	47-57	solute carrier family 22 member 7	Homo sapiens	143-151
18661413-8	2008	In multiple regression analysis, predictors of serum NGAL were creatinine (beta value = 0.97, p = 0.005), cystatin C (beta = 0.34, p = 0.01), and eGFR (beta value = 1.77, p = 0.001).	Creatinine	63-73	lipocalin 2	Homo sapiens	53-57
18661413-9	2008	In the healthy volunteers, serum NGAL correlated with age, serum creatinine, eGFR, leukocyte count, and cystatin C.	Creatinine	65-75	lipocalin 2	Homo sapiens	33-37
25904762-4	2015	The overexpression of OAT2 significantly enhanced the uptake of creatinine in OAT2-HEK cells.	Creatinine	64-74	solute carrier family 22 member 7	Homo sapiens	22-26
25904762-4	2015	The overexpression of OAT2 significantly enhanced the uptake of creatinine in OAT2-HEK cells.	Creatinine	64-74	solute carrier family 22 member 7	Homo sapiens	78-82
25904762-5	2015	Under physiologic conditions (creatinine concentrations of 41.2 and 123.5 microM), the initial rate of OAT2-mediated creatinine transport was approximately 11-, 80-, and 80-fold higher than OCT2, multidrug and toxin extrusion protein (MATE)1, and MATE2K, respectively, resulting in approximately 37-, 1850-, and 80-fold increase of the intrinsic transport clearance when normalized to the transporter protein concentrations.	Creatinine	30-40	solute carrier family 22 member 7	Homo sapiens	103-107
25904762-5	2015	Under physiologic conditions (creatinine concentrations of 41.2 and 123.5 microM), the initial rate of OAT2-mediated creatinine transport was approximately 11-, 80-, and 80-fold higher than OCT2, multidrug and toxin extrusion protein (MATE)1, and MATE2K, respectively, resulting in approximately 37-, 1850-, and 80-fold increase of the intrinsic transport clearance when normalized to the transporter protein concentrations.	Creatinine	117-127	solute carrier family 22 member 7	Homo sapiens	103-107
25904762-7	2015	Collectively, the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine.	Creatinine	111-121	solute carrier family 22 member 7	Homo sapiens	58-62
25904762-7	2015	Collectively, the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine.	Creatinine	218-228	solute carrier family 22 member 7	Homo sapiens	58-62
25863593-4	2015	Residents lived within 3 km to the mine waste heaps showed high Urine Hg (UHg) concentrations and the geometrical means (Geomean) of UHg were 8.29, 5.13, and 10.3 mug/g Creatinine (Cr) at site A, D, and E, respectively.	Creatinine	169-179	small nucleolar RNA host gene 1	Homo sapiens	133-136
25863593-4	2015	Residents lived within 3 km to the mine waste heaps showed high Urine Hg (UHg) concentrations and the geometrical means (Geomean) of UHg were 8.29, 5.13, and 10.3 mug/g Creatinine (Cr) at site A, D, and E, respectively.	Creatinine	169-171	small nucleolar RNA host gene 1	Homo sapiens	133-136
25863593-6	2015	A significantly positive correlation between paired results for UHg concentrations and serum creatinine (SCr) was observed in this study, but not for UHg and blood urea nitrogen (BUN).	Creatinine	93-103	small nucleolar RNA host gene 1	Homo sapiens	64-67
26174458-4	2015	This study assessed kinetic of urine NGAL-creatinine ratio in patients who received cisplatin-containing chemotherapy.	Creatinine	42-52	lipocalin 2	Homo sapiens	37-41
26174458-10	2015	The median increases in urine NGAL-creatinine ratio  were 335% (interquartile range, 320% to 350%) in the patients with AKI and 100% (interquartile range, 73% to 190%) in those without AKI (P = .02) during the first 24 hours after cisplatin administration.	Creatinine	35-45	lipocalin 2	Homo sapiens	30-34
26174458-11	2015	A urine NGAL-creatinine ratio greater than 26.9 ng/mg 24 hours after cisplatin infusion had a sensitivity of 86% and a specificity of 50% to detect cisplatin-associated nephrotoxicity.	Creatinine	13-23	lipocalin 2	Homo sapiens	8-12
26174458-12	2015	CONCLUSIONS: Urine NGAL-creatinine ratio significantly increased in patients with cisplatin-associated AKI.	Creatinine	24-34	lipocalin 2	Homo sapiens	19-23
26174458-13	2015	Urine NGAL-creatinine ratio within the first 24 hours after cisplatin infusion may better predict cisplatin-associated nephrotoxicity than serum creatinine level.	Creatinine	11-21	lipocalin 2	Homo sapiens	6-10
26116550-8	2015	As previously reported, HGF treatment promoted rapid improvement of kidney function as evidenced by creatinine (Cre) and blood urea nitrogen (BUN) levels.	Creatinine	112-115	hepatocyte growth factor	Mus musculus	24-27
26236932-7	2015	Plasma NGAL and urine NGAL were positively correlated with renin, aldosterone, blood creatinine, MELD score, Child-Pugh score and ascites (P &lt; 0.05).	Creatinine	85-95	lipocalin 2	Homo sapiens	7-11
26236932-7	2015	Plasma NGAL and urine NGAL were positively correlated with renin, aldosterone, blood creatinine, MELD score, Child-Pugh score and ascites (P &lt; 0.05).	Creatinine	85-95	lipocalin 2	Homo sapiens	22-26
25814217-9	2015	RESULTS: CNP reduced histological renal tubular damage and apoptosis induced by cisplatin and suppressed plasma blood urea nitrogen and creatinine levels, which were elevated by cisplatin administration.	Creatinine	136-146	natriuretic peptide type C	Mus musculus	9-12
25930108-8	2015	Kallistatin significantly reduced CLP-induced renal injury as well as blood urea nitrogen, serum creatinine, interleukin-6 (IL-6), and high mobility group box-1 (HMGB1) levels.	Creatinine	97-107	serpin family A member 4	Homo sapiens	0-11
26591143-8	2015	Similarly icterus, oedema, hypotension, altered sensorium, thrombocytopenia and raised creatinine were significantly more in NS1 positive patients.	Creatinine	87-97	influenza virus NS1A binding protein	Homo sapiens	125-128
18925531-8	2008	The concentrations of urine NGAL and IL-18 were significantly increased in the AKI group, which reached the peak at 2-4 h postoperation, and a more significant difference could be seen after correction for urine creatinine.	Creatinine	212-222	lipocalin 2	Homo sapiens	28-32
18925531-10	2008	Increased levels of urine NGAL and IL-18 2 h postoperation were significantly correlated with increased level of serum creatinine 12 h postoperation.	Creatinine	119-129	lipocalin 2	Homo sapiens	26-30
18925531-10	2008	Increased levels of urine NGAL and IL-18 2 h postoperation were significantly correlated with increased level of serum creatinine 12 h postoperation.	Creatinine	119-129	interleukin 18	Homo sapiens	35-40
17875187-8	2007	RESULTS: Plasma RBP4 concentrations were positively correlated with serum creatinine levels (r = 0.322, P &lt; 0.001) and inversely correlated with MDRD-GFR (r = -0.468, P = 0.009).	Creatinine	74-84	retinol binding protein 4	Homo sapiens	16-20
25804605-8	2015	Antagonism of CB1 with AM251 significantly reduced weight gain, systolic blood pressure, plasma leptin, and reduced albuminuria and plasma creatinine levels in obese rats.	Creatinine	139-149	cannabinoid receptor 1	Rattus norvegicus	14-17
25607110-4	2015	We also observed that PGRN deficiency (Grn(-/-) mice) significantly aggravated renal injury as evidenced by higher serum creatinine, more severe morphological injury, increased tubular epithelial cell death, and tubulointerstitial neutrophil and macrophage infiltration versus wild-type mice.	Creatinine	121-131	granulin	Mus musculus	39-42
25542909-5	2015	GFR-estimating formulas on the basis of beta-trace protein, creatinine, and height were derived using stepwise linear regression analysis of log-transformed data.	Creatinine	60-70	Rap guanine nucleotide exchange factor 5	Homo sapiens	0-3
25542909-11	2015	CONCLUSIONS: Improved and sex-specific formulas for the estimation of GFR in children on the basis of beta-trace protein, serum creatinine, and height are now available.	Creatinine	128-138	Rap guanine nucleotide exchange factor 5	Homo sapiens	70-73
25851291-7	2015	RESULTS: Urine NGAL was significantly higher in microalbuminuric in comparison with normoalbuminuric patients and controls, and correlated positively with urine albumin-creatinine ratio.	Creatinine	169-179	lipocalin 2	Homo sapiens	15-19
17919619-1	2007	BACKGROUND: Proliferation signal inhibitors (PSI) facilitate reduction in calcineurin inhibitor exposure resulting in an improvement in creatinine clearance (CrCl) in cardiac transplant recipients with renal dysfunction.	Creatinine	136-146	calcineurin binding protein 1	Homo sapiens	74-95
19209788-9	2007	RESULTS: Compared with sham scald group, both mRNA and protein expressions of HMGB1 were significantly enhanced in the kidney at 8, 24, and 72 hours after scald injury (P&lt;0.05, P&lt;0.01), meanwhile serum Cr contents were markedly increased following acute insults (P&lt;0.05, P&lt;0.01).	Creatinine	208-210	high mobility group box 1	Rattus norvegicus	78-83
17599764-8	2007	Renal CD8+ T cell infiltration correlated well with the renal activity index (r = 0.63, P = 0.0007) and with high serum creatinine levels (r = 0.75, P = 0.0001).	Creatinine	120-130	CD8a molecule	Homo sapiens	6-9
17492427-7	2007	Moreover, we found significant correlations between FASN expression and markers of renal function, including serum creatinine and urinary albumin excretion.	Creatinine	115-125	fatty acid synthase	Homo sapiens	52-56
26037257-9	2015	A rise in serum creatinine was always preceded by increased urinary excretion of NGAL that, in turn, was associated with preoperative fluid retention.	Creatinine	16-26	lipocalin 2	Homo sapiens	81-85
25689900-5	2015	The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV &gt;1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise.	Creatinine	372-382	cardiotrophin 1	Mus musculus	97-112
26491688-1	2015	The aim of this study was to assess the significance of the neutrophil gelatinase-associated lipocalin/serum creatinine ratio (NGAL/sCr ratio) in patients with renal dysfunction.	Creatinine	109-119	lipocalin 2	Homo sapiens	127-131
25341894-5	2015	In multiple regression, age, creatinine, and clinical signs of increased cerebral ischaemia were independent predictors of FPR2/ALX expression.	Creatinine	29-39	formyl peptide receptor 2	Mus musculus	123-127
25316431-4	2015	HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP.	Creatinine	40-42	hepatitis A virus cellular receptor 1	Homo sapiens	71-76
24898921-2	2015	We aimed to assess the association between serum BDNF levels and structural endothelial dysfunction (ED) as determined by cross-sectional wall area (CSWA) and albumin/creatinine ratio (ACR) in black Africans.	Creatinine	167-177	brain derived neurotrophic factor	Homo sapiens	49-53
17410096-6	2007	Compared with the wild-type mice renal function, as measured by blood urea nitrogen and serum creatinine, was partially but significantly preserved in Bax knockout mice.	Creatinine	94-104	BCL2-associated X protein	Mus musculus	151-154
25039814-11	2015	As telaprevir has been shown to inhibit mostly the drug transporter OCT2 which interacts with creatinine transport, the early decrease of eGFR observed could be a benign phenomenon.	Creatinine	94-104	POU class 2 homeobox 2	Homo sapiens	68-72
25501268-12	2015	cTnI was positively correlated with age, D-dimer and creatinine.	Creatinine	53-63	troponin I3, cardiac type	Homo sapiens	0-4
25531096-9	2015	Serum creatinine slightly increased in PCK rats on vehicle and was similar to controls after bindarit.	Creatinine	6-16	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	39-42
17189607-9	2007	Plasma creatinine phosphokinase as well as muscle mitochondria, cholesterol, and lipid droplet levels were increased in statin-treated mice overexpressing LPL in skeletal muscle.	Creatinine	7-17	lipoprotein lipase	Mus musculus	155-158
25662930-0	2015	Relative and absolute changes in urinary neutrophil gelatinase-associated lipocalin and correlation with small increases in serum creatinine levels after coronary angiography: an observational study.	Creatinine	130-140	lipocalin 2	Homo sapiens	41-83
26330088-1	2015	BACKGROUND/AIM: Several methods have been proposed for the better estimation of creatinine clearance (CLCR) in spinal cord injury (SCI); however, there is no standard method to date.	Creatinine	80-90	chymotrypsin C	Homo sapiens	102-106
17283261-9	2007	At this cutoff value, GDF-15 added significant prognostic information in patient subgroups defined by age; gender; time from symptom onset to admission; cardiovascular risk factors; previous cardiovascular disease; and the risk markers ST-segment depression, troponin T, N-terminal pro-B-type natriuretic peptide, C-reactive protein, and creatinine clearance.	Creatinine	338-348	growth differentiation factor 15	Homo sapiens	22-28
17253815-1	2007	The hydride affinities of 80 various p- and o-quinones in DMSO solution were predicted by using B3LYP/6-311++G (2df,p)//B3LYP/6-31+G* and MP2/6-311++G**//B3LYP/6-31+G* methods, combined with the PCM cluster continuum model for the first time.	Creatinine	4-11	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	98-101
25049066-9	2014	NGAL was higher in patients who developed right ventricular failure (187.8 +- 66.0 vs 130.9 +- 67.0 ng/mL, p = 0.03) and irreversible renal dysfunction (190.0 +- 73.8 ng/mL vs 133.8 +- 54.2 ng/mL, p &lt; 0.05), whereas cystatin C, creatinine, and eGFR were not different.	Creatinine	231-241	lipocalin 2	Homo sapiens	0-4
24981581-6	2014	Over 4.8 years, higher HF1 and SF predicted (P &lt;= 0.014) lowering of eGFR; higher HF2 predicted (P &lt;= 0.049) increase in serum creatinine and decrease eGFR.	Creatinine	133-143	complement factor H	Homo sapiens	85-88
18001501-4	2007	Furthermore, this rise in NGAL occurs in various studies at 24 to 48 hours before the rise in creatinine is observed.	Creatinine	94-104	lipocalin 2	Homo sapiens	26-30
18070344-13	2007	The 2 hour postoperative plasma NGAL levels strongly correlated with change in creatinine (r = 0.46, P &lt; 0.001), duration of AKI (r = 0.57, P &lt; 0.001), and length of hospital stay (r = 0.44, P &lt; 0.001).	Creatinine	79-89	lipocalin 2	Homo sapiens	32-36
16942925-3	2006	Urinary excretion of GGT, corrected for creatinine, was found to be increased in osteoprotegerin (OPG)-deficient osteoporotic mice as well as in patients with postmenopausal osteoporosis (67-83 years of age); in both cases the urinary level decreased after treatment of patients or mice with alendronate, a selective inhibitor of bone resorption, concomitantly with a reduction in DPD and NTX.	Creatinine	40-50	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	81-96
16978023-7	2006	The mean concentration of AFB(1)-N(7)-Gua, measured in 16/20 urine samples with levels above the method"s limit of quantitation, was 2.9 pg/20 mL urine (0.28 pg/mg creatinine) with a range of &lt;0.8-7.2 pg/20 mL urine (0.04-65 pg/mg creatinine).	Creatinine	164-174	DExD-box helicase 21	Homo sapiens	38-41
16487505-8	2006	The VDR polymorphism did modify associations between the other lead biomarkers and the serum creatinine and calculated creatinine clearance.	Creatinine	93-103	vitamin D receptor	Homo sapiens	4-7
16487505-8	2006	The VDR polymorphism did modify associations between the other lead biomarkers and the serum creatinine and calculated creatinine clearance.	Creatinine	119-129	vitamin D receptor	Homo sapiens	4-7
16487505-11	2006	Limited evidence of effect modification by ALAD genotype was observed; higher blood lead levels were associated with higher calculated creatinine clearance among participants with the ALAD(1-2) genotype.	Creatinine	135-145	aminolevulinate dehydratase	Homo sapiens	184-188
16452535-7	2006	Smokers showed significantly elevated urinary SCN-/creatinine ratios in comparison to non-smokers (4.3 +/- 4.3 vs 2.4 +/- 2.1 mg SCN-/g creatinine).	Creatinine	136-146	sorcin	Homo sapiens	46-50
25185859-5	2014	RESULTS: Plasma FGF-23 concentrations were significantly and positively correlated with abdominal muscle areas and Cr production (rho = 0.301, P &lt; 0.01 and rho = 0.345, P &lt; 0.01, respectively).	Creatinine	115-117	fibroblast growth factor 23	Homo sapiens	16-22
24687388-7	2014	Urinary NAP was positively correlated with all urinary tubular markers after adjustment for age, duration of diabetes, systolic blood pressure, eGFR, low-density lipoprotein cholesterol, HbA1c and albumin-to-creatinine ratio (KIM-1 r = 0.170, p &lt; 0.001; NGAL r = 0.142, p &lt; 0.015 and L-FABP r = 0.262, p &lt; 0.001).	Creatinine	208-218	catenin beta like 1	Homo sapiens	8-11
25193108-8	2014	We found an inverse relationship between serum alpha-Klotho and serum creatinine (r = -0.36, P = .007), proteinuria (r = -0.36, P = .013), and a positive relationship with serum bicarbonate (r = 0.33, P = .011).	Creatinine	70-80	klotho	Homo sapiens	53-59
25299197-10	2014	Univariate regression analysis showed that the percent changes in serum RBP4 concentration before and after kidney transplantation were positively correlated with serum creatinine, blood urea nitrogen, phosphate, and pre-albumin concentrations and negatively correlated with the estimated glomerular filtration rate.	Creatinine	169-179	retinol binding protein 4	Homo sapiens	72-76
25053723-7	2014	ADM expression correlated with plasma C-reactive protein, interleukin-receptor 1A, and myeloperoxidase, whereas MR-pro-ADM levels correlated with C-terminal proendothelin-1, creatinine, and N-terminal pro-B-type natriuretic peptide.	Creatinine	174-184	adrenomedullin	Homo sapiens	119-122
24994759-6	2014	Urinary RBP4 correlated strongly with homeostasis model assessments of insulin resistance (HOMA-IR), fasting glucose, triglycerides, blood pressure, hsCRP, arterial stiffness, estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio (all P&lt;0.01).	Creatinine	237-247	retinol binding protein 4	Homo sapiens	8-12
16772710-3	2006	Therefore, the aim of our study was to assess prospectively NGAL in patients undergoing elective PCI in relation to serum creatinine.	Creatinine	122-132	lipocalin 2	Homo sapiens	60-64
16772710-7	2006	Before PCI, serum NGAL was significantly associated with serum creatinine, urea, urinary NGAL, hemoglobin, hematocrit, albumin, age and presence of diabetes.	Creatinine	63-73	lipocalin 2	Homo sapiens	18-22
16772710-8	2006	In multivariate analysis, serum creatinine was the only predictor of serum NGAL.	Creatinine	32-42	lipocalin 2	Homo sapiens	75-79
16772710-9	2006	Serum NGAL 2 h after PCI correlated with serum creatinine, duration of PCI, HbA1c, hematocrit, hemoglobin and urinary NGAL.	Creatinine	47-57	lipocalin 2	Homo sapiens	6-10
16772710-10	2006	In multivariate analysis, the only predictors of serum NGAL 2 h after PCI were serum creatinine, time of PCI and HbA1c.	Creatinine	85-95	lipocalin 2	Homo sapiens	55-59
16772710-13	2006	Serum creatinine, duration of PCI, but not type and amount of contrast agent, and appropriate treatment of diabetes, reflected by HbA1c, predict a rise in serum NGAL and kidney function following PCI.	Creatinine	6-16	lipocalin 2	Homo sapiens	161-165
16374426-6	2006	Diabetes of 18 weeks resulted in albuminuria and elevated plasma creatinine in MCP-1(+/+) mice, but these aspects of renal injury were largely suppressed in MCP-1(-/-) mice.	Creatinine	65-75	chemokine (C-C motif) ligand 2	Mus musculus	79-84
16898494-10	2006	CONCLUSIONS: The DIP creatinine equilibration curves were similar to the previously published reference curves for children, whereas those for glucose was significantly lower.	Creatinine	21-31	DIP	Homo sapiens	17-20
17441364-8	2006	Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18.	Creatinine	6-16	interleukin 18	Homo sapiens	39-44
15943635-4	2005	CNI withdrawal from sirolimus-based therapy, was associated with an increased risk of acute rejection (risk difference, 6%; 95% CI 2-10%, p = 0.002) but a higher creatinine clearance (mean difference, 7.49 mL/min; 95% CI 5.08-9.89 mL/min, p &lt; 0.00001) at 1 year compared to continued CNI and sirolimus therapy.	Creatinine	162-172	calcineurin binding protein 1	Homo sapiens	0-3
25019387-8	2014	In deceased-donor kidney transplant, the mean urinary neutrophil gelatinase-associated lipocalin level in the perfusion fluid was significantly greater from donors who had terminal serum creatinine &gt; 150 mumol/L, and urinary neutrophil gelatinase-associated lipocalin level at 6 hours after transplant was significantly greater in transplants with longer cold ischemia time and donors who had hypertension.	Creatinine	187-197	lipocalin 2	Homo sapiens	54-96
24904085-10	2014	In a cohort of patients with type 1 diabetes and proteinuria, serum KIM-1 level at baseline strongly predicted rate of eGFR loss and risk of ESRD during 5-15 years of follow-up, after adjustment for baseline urinary albumin-to-creatinine ratio, eGFR, and Hb1Ac.	Creatinine	227-237	hepatitis A virus cellular receptor 1	Homo sapiens	68-73
25607262-10	2014	CONCLUSION: An increase in urine neutrophil gelatinase-associated lipocalin precedes variations in serum creatinine in patients with acute kidney injury and may be associated with death.	Creatinine	105-115	lipocalin 2	Homo sapiens	33-75
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p&lt;0.0001).	Creatinine	109-119	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p&lt;0.0001).	Creatinine	231-241	glutathione S-transferase theta 1	Homo sapiens	66-71
15894970-9	2005	CONCLUSIONS: Both ischemic and bleeding complications are highest in the lowest creatinine clearance quartile of patients treated with GP IIb/IIIa inhibitors.	Creatinine	80-90	integrin subunit alpha 2b	Homo sapiens	135-141
15882434-4	2005	Kidney damages, which were evaluated by levels of blood urea nitrogen (BUN) and creatinine, showed that MBL DKO mice were significantly protected compared with WT mice.	Creatinine	80-90	mannose-binding lectin (protein C) 2	Mus musculus	104-107
15798956-2	2005	Polymorphisms G1704T and G82S of the RAGE gene were examined with genomic DNA obtained from 116 type 2 diabetic patients with microalbuminuria (urinary albumin/creatinine ratio between 30 and 300 mg/g of creatinine) (microalbuminuria group), and 232 patients with normoalbuminuria (urinary albumin/creatinine ratio &lt;30 mg/g of creatinine) (normoalbuminuria group).	Creatinine	204-214	long intergenic non-protein coding RNA 914	Homo sapiens	37-41
15798956-2	2005	Polymorphisms G1704T and G82S of the RAGE gene were examined with genomic DNA obtained from 116 type 2 diabetic patients with microalbuminuria (urinary albumin/creatinine ratio between 30 and 300 mg/g of creatinine) (microalbuminuria group), and 232 patients with normoalbuminuria (urinary albumin/creatinine ratio &lt;30 mg/g of creatinine) (normoalbuminuria group).	Creatinine	204-214	long intergenic non-protein coding RNA 914	Homo sapiens	37-41
15798956-2	2005	Polymorphisms G1704T and G82S of the RAGE gene were examined with genomic DNA obtained from 116 type 2 diabetic patients with microalbuminuria (urinary albumin/creatinine ratio between 30 and 300 mg/g of creatinine) (microalbuminuria group), and 232 patients with normoalbuminuria (urinary albumin/creatinine ratio &lt;30 mg/g of creatinine) (normoalbuminuria group).	Creatinine	204-214	long intergenic non-protein coding RNA 914	Homo sapiens	37-41
15647342-7	2005	DNase I KO mice were also markedly protected against the toxic injury induced by a single injection of cisplatin (20 mg/kg), by both functional (blood urea nitrogen and serum creatinine) and histologic criteria (tubular necrosis and in situ DNA fragmentation assessed by the terminal deoxynucleotidyl transferase nick end-labeling).	Creatinine	175-185	deoxyribonuclease I	Mus musculus	0-7
15689404-5	2005	When pretreated with G-CSF or G-CSF + M-CSF, the mice showed longer survival and lower serum creatinine and blood urea nitrogen levels than mice that had been received injections of M-CSF or saline.	Creatinine	93-103	colony stimulating factor 1 (macrophage)	Mus musculus	38-43
15729165-5	2005	In addition, ME/PS-modified ICAM-1 antisense oligo reduced ischemic-reperfusion injury in kidneys, as measured by glomerular filtration rate, creatinine levels, and infiltration with leukocytes.	Creatinine	142-152	intercellular adhesion molecule 1	Homo sapiens	28-34
24674095-11	2014	Further, the predictabilities of serum FGF23 were comparable among renal Cr clearance, Kt/V for urea, and renal phosphate clearance.	Creatinine	73-75	fibroblast growth factor 23	Homo sapiens	39-44
24674095-12	2014	RRF determined by renal Cr clearance or residual urine volume is an independent negative determinant of serum FGF23 levels in PD patients.	Creatinine	24-26	fibroblast growth factor 23	Homo sapiens	110-115
25129409-2	2014	Using liquid chromatography-mass spectrometry (LC/MS), we developed an assay that allows for simultaneous quantitation of plasma and urinary levels of N(1)-methylnicotinamide (a substrate of hOCT2/hMATEs), L-carnitine (a substrate of hOCTN2), and creatinine (an indicator of glomerular filtration).	Creatinine	247-257	POU class 2 homeobox 2	Homo sapiens	191-196
15494543-6	2005	The levels of plasma creatinine were decreased and GFR was augmented in PARP-/- mice.	Creatinine	21-31	poly (ADP-ribose) polymerase family, member 1	Mus musculus	72-76
15559485-16	2004	When analyzed as continuous variables, MTAC creatinine was related to VEGF (r= 0.33, p &lt; 0.05) and CA125 (r= 0.41, p = 0.03).	Creatinine	44-54	mucin 16, cell surface associated	Homo sapiens	102-107
15559485-17	2004	In linear regression analysis, VEGF influenced the association between CA125 and MTAC creatinine; IL-6 weakened this association only marginally.	Creatinine	86-96	mucin 16, cell surface associated	Homo sapiens	71-76
15327399-5	2004	Proteinuria was significantly reduced in mice treated with recombinant uteroglobin compared with disease-control mice at 7 and 14 days after an anti-GBM antibody injection, although the serum creatinine concentration was similar in both groups.	Creatinine	192-202	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	71-82
25000576-6	2014	Tap water consumption was significantly associated with creatinine-adjusted urinary TCAA concentration (beta = 0.23 mug/g creatinine per log10 unit; 95% CI: 0.12, 0.35).	Creatinine	56-66	nuclear RNA export factor 1	Homo sapiens	0-3
15341658-3	2004	RESULTS: TTR levels as determined by ELISA in plasma and urine of healthy individuals were 489 +/- 155 microg/ml plasma and 46 +/- 24 ng/g creatinine, respectively.	Creatinine	139-149	transthyretin	Homo sapiens	9-12
15264182-5	2004	RESULTS: Serum FGF-23 levels increased with the decrease in creatinine clearance (Ccr).	Creatinine	60-70	fibroblast growth factor 23	Homo sapiens	15-21
15223229-6	2004	The betaig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6 +/- 9.27), microalbuminuria (120.2 +/- 14.48), and overt proteinuria (146.3 +/- 16.34), when compared with control subjects (64.8 +/- 7.14) (P &lt; 0.01).	Creatinine	17-27	transforming growth factor beta induced	Homo sapiens	4-13
15284300-6	2004	Furthermore, inhibition of PBR accelerated the recovery of normal renal function, as assessed by measurement of levels of plasma creatinine and blood urea nitrogen.	Creatinine	129-139	translocator protein	Rattus norvegicus	27-30
15237243-9	2004	A Cox proportional hazards model adjusting for baseline covariates including age, gender, race, type of transplant, delayed graft function, baseline blood pressure and random serum glucose and cholesterol demonstrated that only calcineurin inhibitor dose reduction but not withdrawal, older age, delayed graft function, higher serum creatinine at the time of intervention, and higher diastolic blood pressure and serum glucose, correlated with graft loss.	Creatinine	333-343	calcineurin binding protein 1	Homo sapiens	228-249
15248218-9	2004	In a survival analysis, patients homozygous for CYP2B6*5 (n = 3) or CYP2C19*2 (n = 4) had a higher probability of reaching ESRD (P = 0.0005) and of doubling the creatinine level (P = 0.0005) as well as a trend toward a lower probability of achieving a complete renal response (P = 0.051).	Creatinine	161-171	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	68-75
25000576-6	2014	Tap water consumption was significantly associated with creatinine-adjusted urinary TCAA concentration (beta = 0.23 mug/g creatinine per log10 unit; 95% CI: 0.12, 0.35).	Creatinine	122-132	nuclear RNA export factor 1	Homo sapiens	0-3
25243068-15	2014	Serum NGAL levels exhibited a positive correlation with white blood cell (WBC), neutrophil, C-reactive protein (CRP), sedimentation, serum LDH, creatinine, pleural leukocyte and pleural neutrophil numbers.	Creatinine	144-154	lipocalin 2	Homo sapiens	6-10
25182190-5	2014	RESULTS: The expression of both miR-155 and miR-146a was increased more than fivefold in the kidney samples of the DN patients compared with the controls, and the miR-155 expression was closely correlated with the serum creatinine levels (R = 0.95, P = 0.004).	Creatinine	220-230	microRNA 155	Homo sapiens	32-39
25182190-5	2014	RESULTS: The expression of both miR-155 and miR-146a was increased more than fivefold in the kidney samples of the DN patients compared with the controls, and the miR-155 expression was closely correlated with the serum creatinine levels (R = 0.95, P = 0.004).	Creatinine	220-230	microRNA 155	Homo sapiens	163-170
25068144-19	2014	CONCLUSIONS: NGAL and IL-18 obviated the disadvantages of creatinine.	Creatinine	58-68	lipocalin 2	Homo sapiens	13-17
15203259-9	2004	Serum creatinine was higher in cTnI-positive group (3.58+/-2.73 vs. 1.83+/-2.01 mg/dl, P=0.02) but there was no correlation between serum creatinine and cTnI (r(2)=0.121, P=0.158).	Creatinine	6-16	troponin I3, cardiac type	Homo sapiens	31-35
14764738-8	2004	In contrast, Daf1(-/-) mice developed severe albuminuria (378 +/- 520, p &lt; 0.05) that was further exacerbated in Daf1(-/-)CD59a(-/-) mice (577 +/- 785 micro g/mg creatinine, p &lt; 0.05).	Creatinine	165-175	CD55 molecule, decay accelerating factor for complement	Mus musculus	13-17
14764738-8	2004	In contrast, Daf1(-/-) mice developed severe albuminuria (378 +/- 520, p &lt; 0.05) that was further exacerbated in Daf1(-/-)CD59a(-/-) mice (577 +/- 785 micro g/mg creatinine, p &lt; 0.05).	Creatinine	165-175	CD55 molecule, decay accelerating factor for complement	Mus musculus	116-120
14764738-8	2004	In contrast, Daf1(-/-) mice developed severe albuminuria (378 +/- 520, p &lt; 0.05) that was further exacerbated in Daf1(-/-)CD59a(-/-) mice (577 +/- 785 micro g/mg creatinine, p &lt; 0.05).	Creatinine	165-175	CD59a antigen	Mus musculus	125-130
25317609-9	2014	CONCLUSION: AKI was noted in 78% of patients with HNC treated with cisplatin and showed the correlation of NGAL with creatinine and GFR in demonstrating renal injury.	Creatinine	117-127	lipocalin 2	Homo sapiens	107-111
24673459-6	2014	In this context, a recent prospective study by our group evaluated plasma NGAL, measured using standardized Tauriage  NGAL test (Biosite Incorporated, San Diego, CA) at baseline and 6-h post-procedure, for early detection of CIN among hospitalized patients undergoing elective contrast-enhanced CT. CIN, defined as an increase in serum creatinine (SCr) of &gt;25% or &gt;0.5 mg/dL from baseline within 48-h post-procedure, was found in 8.51% of subjects.	Creatinine	336-346	lipocalin 2	Homo sapiens	74-78
24631962-7	2014	CsA impaired urea clearance and creatinine clearance were significantly improved by concomitant administration of CSP.	Creatinine	32-42	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	114-117
15931697-7	2004	If both creatinine clearance and age as independent factors were correlated with fasting plasma homocysteine levels using multiple regression analysis, it was shown that both variable had strong (r=0.5) and significant relationship (p=0.03), yielding regression equations: Hcy (mmol/L) = -0.20 Cct (ml/mnt) + 0.21 age (ys) + 12.8.	Creatinine	8-18	CCT	Homo sapiens	294-297
24206243-5	2014	Compared with the WT (wild-type) mice, CRP Tg mice developed more severe renal injury at 24 h after ischaemia as determined by significantly increased serum creatinine and tubular necrosis.	Creatinine	157-167	C-reactive protein, pentraxin-related	Mus musculus	39-42
24309189-1	2014	Estimation of GFR from serum concentrations of creatinine and cystatin C has been refined using cross-sectional data from large numbers of people.	Creatinine	47-57	Rap guanine nucleotide exchange factor 5	Homo sapiens	14-17
14709371-5	2004	Urinary cyclic GMP excretion was 66.0+/-62.0nmol/mmol creatinine (mean+/-S.D.).	Creatinine	54-64	5'-nucleotidase, cytosolic II	Homo sapiens	15-18
14988590-4	2004	RESULTS: Mice deficient in TSP1 developed significantly less proteinuria than their wild-type controls 21 days after induction of disease (5,793 +/- 5,456 vs. 24,293 +/- 15,336 microg albumin/mg creatinine; p = 0.002).	Creatinine	195-205	thrombospondin 1	Mus musculus	27-31
14988590-5	2004	Serum creatinine levels were significantly higher in the wild-type mice than in the TSP1 deficient animals (29.03 +/- 2.34 vs. 16.39 +/- 2.87 micromol/l; p = 0.005).	Creatinine	6-16	thrombospondin 1	Mus musculus	84-88
14988661-10	2004	However, serum creatinine levels were inversely correlated to urinary L-PGDS excretions (r = -0.88, p &lt; 0.05).	Creatinine	15-25	prostaglandin D2 synthase (brain)	Mus musculus	70-76
14633152-4	2003	METHODS: Using a two-site enzyme-linked immunosorbent assay (ELISA) detecting the C-terminal portion of FGF-23, serum concentration was measured in 20 patients with different stages of renal failure (creatinine range 155 to 724 micromol/L), in 33 patients with end-stage renal disease (ESRD) on dialysis treatment, and in 30 patients with functioning renal grafts.	Creatinine	200-210	fibroblast growth factor 23	Homo sapiens	104-110
14633152-7	2003	RESULTS: FGF-23 serum levels were significantly elevated in CKD with a strong correlation between serum creatinine and FGF-23 concentration.	Creatinine	104-114	fibroblast growth factor 23	Homo sapiens	9-15
14633152-10	2003	CONCLUSION: Circulating FGF-23 was significantly elevated in patients with CKD and its concentration correlated with renal creatinine clearance.	Creatinine	123-133	fibroblast growth factor 23	Homo sapiens	24-30
14605060-14	2003	CONCLUSION: The risk-adjusted association between preoperative renal dysfunction and adverse events after cardiac surgery is stronger with estimated ClCr than with plasma creatinine level, particularly in patients with normal plasma creatinine levels.	Creatinine	233-243	chymotrypsin C	Homo sapiens	149-153
12937307-2	2003	It was previously shown that patients with low creatinine production were malnourished and had low serum creatinine levels and creatinine clearances (CrCl) but high MDRD GFR at initiation of dialysis.	Creatinine	47-57	Rap guanine nucleotide exchange factor 5	Homo sapiens	170-173
24392854-8	2014	GGT-to-creatinine ratio of the Lambda BJP group was significantly higher than Kappa BJP group and controls (p = 0.018 and 0.002, respectively).	Creatinine	7-17	gamma-glutamyltransferase 1	Homo sapiens	0-3
24392854-10	2014	Our data have demonstrated that urinary GGT-to-creatinine ratio could be a tubular damage marker of lambda light chain proteinuria.	Creatinine	47-57	gamma-glutamyltransferase 1	Homo sapiens	40-43
24361613-6	2014	RESULTS: Compared to saline, Trx or N-acetylcysteine, an intravenous administration of HSA-Trx attenuated the cisplatin-induced elevation in serum creatinine, blood urea nitrogen and urinary N-acetyl-beta-d-glucosaminidase along with the decrease in creatinine clearance.	Creatinine	147-157	thioredoxin 1	Mus musculus	91-94
12950984-5	2003	Creatinine clearance was 1.16 +/- 1.24 ml/min for hDAF kidneys and 0.22 +/- 0.15 ml/min for non-hDAF kidneys (P &lt; 0.05).	Creatinine	0-10	CD55 molecule (Cromer blood group)	Homo sapiens	50-54
12763641-0	2003	Circulating adrenomedullin is increased in relation with increased creatinine and atrial natriuretic peptide in liver-transplant recipients.	Creatinine	67-77	adrenomedullin	Homo sapiens	12-26
12611663-11	2003	There was evidence of a significant (p = 0.025) interaction of tibia lead with genotype (ALAD 1-1 vs. ALAD 1-2/2-2) regarding serum creatinine as an outcome, but in the same linear regression model tibia lead alone was not a significant predictor of serum creatinine.	Creatinine	132-142	aminolevulinate dehydratase	Homo sapiens	89-93
12595503-7	2003	Urinary albumin excretion at 24 wk was also significantly reduced from 5.3 +/- 1.4 mg/mg creatinine in the control groups to 0.5 +/- 0.2 mg/mg creatinine in the Crry-Ig-treated group (P &lt; 0.05).	Creatinine	143-153	complement component (3b/4b) receptor 1-like	Mus musculus	161-165
12560157-7	2003	The nNOS expression in macula densa and eNOS increased significantly with combination therapy compared to quinapril treatment alone contributing to an enhanced urinary excretion of cGMP and to maintain the creatinine clearance.	Creatinine	206-216	nitric oxide synthase 1	Rattus norvegicus	4-8
24361613-6	2014	RESULTS: Compared to saline, Trx or N-acetylcysteine, an intravenous administration of HSA-Trx attenuated the cisplatin-induced elevation in serum creatinine, blood urea nitrogen and urinary N-acetyl-beta-d-glucosaminidase along with the decrease in creatinine clearance.	Creatinine	250-260	thioredoxin 1	Mus musculus	91-94
24366079-9	2014	Three days after induction of hypertension, a significantly higher albuminuria was found in IL-17-deficient than in wild-type mice (196+-64 versus 58+-16 mg/mg albumin/creatinine).	Creatinine	168-178	interleukin 17A	Mus musculus	92-97
24931412-8	2014	Removal of blood NGAL by continuous hemodiafiltration was shown to be 70-75% lower than that of creatinine.	Creatinine	96-106	lipocalin 2	Homo sapiens	17-21
25174929-8	2014	In HF patients, NGAL levels were positively correlated with Creatinine levels (r=0.40, p&lt;0.001), TNFa levels (r=0.43, p&lt;0.001), BNP levels (r=0.36, p=0.003), MMP-9 levels (r=0.37, p=0.02) and inversely correlated with left ventricle ejection fraction (r=-0.23, p=0.045).	Creatinine	60-70	lipocalin 2	Homo sapiens	16-20
12500206-7	2003	Among ascitic patients, those with high LBP showed greater (P &lt;.05) levels of sCD14, tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), nitrites + nitrates (NOx)/creatinine, and renin, and lower vascular resistance.	Creatinine	177-187	lipopolysaccharide binding protein	Homo sapiens	40-43
24903210-1	2014	OBJECTIVE: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine.	Creatinine	265-275	carbonic anhydrase 2	Homo sapiens	93-98
24878981-8	2014	Plasma adrenomedullin and CGRP correlated significantly negatively with serum creatinine and positively with mean 24 hours arterial blood pressure in patients with diabetes mellitus but not in control subjects.	Creatinine	78-88	adrenomedullin	Homo sapiens	7-21
23849457-11	2013	At follow-up, AZGP1 levels were still increased but now correlated significantly with creatinine, eGFR and urea.	Creatinine	86-96	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	14-19
23837450-6	2013	RESULTS: Urinary KIM-1/creatinine (Cr) was significantly decreased in patients with IgAN after treatment compared to baseline (P &lt; 0.0001, 1.16 [0.51-1.83] vs 0.26 [0.12-0.65] ng/mg).	Creatinine	23-33	hepatitis A virus cellular receptor 1	Homo sapiens	17-22
23419019-1	2013	AIM: The objective of this study was to establish age-dependent urine NGAL (neutrophil gelatinase-associated lipocalin)/creatinine ratio values in healthy children and adolescents.	Creatinine	120-130	lipocalin 2	Homo sapiens	70-74
12720047-11	2003	Creatinine-corrected DPD in postmenopausal ( Z score = 2.4, P &lt; 0.05, n = 17) and osteoporotic ( Z score = 3.0, P &lt; 0.01, n = 29) women were 44% and 64% higher, respectively, compared to premenopausal samples ( n = 15).	Creatinine	0-10	dihydropyrimidine dehydrogenase	Homo sapiens	21-24
23419019-7	2013	Statistically significant negative correlation between urine NGAL/creatinine and age of subjects was found (r = -0.29, p &lt; 0.05).	Creatinine	66-76	lipocalin 2	Homo sapiens	61-65
23940992-12	2013	Together with other recent studies this may suggest that creatinine-based estimates of GFR indicating hyperfiltration is not associated with higher UAE and subsequent development of microalbuminuria.	Creatinine	57-67	Rap guanine nucleotide exchange factor 5	Homo sapiens	87-90
12771537-9	2003	Effluent CA 125 was significantly increased in patients with an MTAC of creatinine &gt;11 ml/min (40.2 +/- 11.2 vs. 20.7 +/- 1.2 U/ml) and in patients with a d/p ratio of creatinine &gt;0.72 (48.2 +/- 11.0 vs. 21.6 +/- 1.6 U/ml).	Creatinine	72-82	mucin 16, cell surface associated	Homo sapiens	9-15
12771537-9	2003	Effluent CA 125 was significantly increased in patients with an MTAC of creatinine &gt;11 ml/min (40.2 +/- 11.2 vs. 20.7 +/- 1.2 U/ml) and in patients with a d/p ratio of creatinine &gt;0.72 (48.2 +/- 11.0 vs. 21.6 +/- 1.6 U/ml).	Creatinine	171-181	mucin 16, cell surface associated	Homo sapiens	9-15
12778878-3	2003	The clinical quantification of renal function is usually thought to require determination of plasma clearance of endogenous creatinine (ClCr), an impractical test for epidemiological evaluation.	Creatinine	124-134	chymotrypsin C	Homo sapiens	136-140
12778878-4	2003	For this reason several formulae have been proposed to estimate the ClCr from the serum creatinine concentration, such as sex, age, and body weight.	Creatinine	88-98	chymotrypsin C	Homo sapiens	68-72
12324495-2	2002	We developed a strategy for the detection of AGAT and GAMT defects by measurement of guanidinoacetate (GAA) and creatine plus creatinine (Cr+Crn) in biological fluids.	Creatinine	126-136	glycine amidinotransferase	Homo sapiens	45-49
23737969-10	2013	Body weight &gt;=40 kg and homozygosity for UGT1A1*6 were risk factors of creatinine elevation (OR = 8.48, 95% CI = 1.7-43.57, P = 0.010 and OR = 14.17, 95% CI = 1.34-150.35, P = 0.028).	Creatinine	74-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	44-50
23792525-6	2013	RESULTS: The rs5498 ICAM1 GG genotype was an independent risk factor associated with increased creatinine concentration at 12, 24, 36, 48, and 60 months after transplantation (p=0.0004, p=0.02, p=0.01, p=0.01 and p=0.04, respectively).	Creatinine	95-105	intercellular adhesion molecule 1	Homo sapiens	20-25
23361515-12	2013	In the case of dppf slow heterolytic splitting of dihydrogen occurs to form the hydride complex [(dppf)PdH(2-(diphenylphosphino)pyridinium)](OTf)2 which contains a protonated 2-(diphenylphosphino)pyridine ligand.	Creatinine	80-87	POU class 2 homeobox 2	Homo sapiens	141-146
12476590-6	2002	In 17 patients whose compliance fluctuated between rank A and B, their rate of GFR decline(ml/min/month) was significantly faster(-2.40 +/- 2.59 vs 0.99 +/- 1.41, p &lt; 0.01), their rate of serum creatinine elevation(mg/dl/month) was significantly higher(0.90 +/- 0.79 vs -0.42 +/- 0.45, p &lt; 0.01) and their rate of serum urea nitrogen increase(mg/dl/month) was significantly larger(15.3 +/- 12.4 vs -10.0 +/- 12.9, p &lt; 0.01) during the period of rank B than rank A.	Creatinine	197-207	Rap guanine nucleotide exchange factor 5	Homo sapiens	79-82
12032189-5	2002	RESULTS: Circulating levels of tenascin and TIMP-1 were moderately, but significantly, higher in patients with chronic renal disease (n=54; mean creatinine clearance, 62 ml/min) than in healthy controls (n=176).	Creatinine	145-155	tenascin C	Homo sapiens	31-39
12032189-6	2002	Urine concentrations per mg creatinine of tenascin and TIMP-1 were significantly lower than serum levels, but were on average six- and 18-fold higher, respectively, in patients with renal disease than in controls.	Creatinine	28-38	tenascin C	Homo sapiens	42-50
11976926-8	2002	In addition, the tissue level of GCs supplying energy, such as CT and beta-GPA, the precursor of CT (GAA) and its metabolite (CTN) were enhanced under dehydration.	Creatinine	126-129	alpha glucosidase	Rattus norvegicus	101-104
23447550-9	2013	Complex 4 reacts with LiI to give the diiodido derivative mer-[I2(PMe3)3Re Ge-C6H3-2,6-Trip2] (5), which undergoes a metathetical iodide/hydride exchange with Na(BEt3H) to give the dihydrido germylidyne complex mer-[H2(PMe3)3Re Ge-C6H3-2,6-Trip2] (6).	Creatinine	137-144	mediator complex subunit 1	Homo sapiens	87-92
23447550-9	2013	Complex 4 reacts with LiI to give the diiodido derivative mer-[I2(PMe3)3Re Ge-C6H3-2,6-Trip2] (5), which undergoes a metathetical iodide/hydride exchange with Na(BEt3H) to give the dihydrido germylidyne complex mer-[H2(PMe3)3Re Ge-C6H3-2,6-Trip2] (6).	Creatinine	137-144	mediator complex subunit 1	Homo sapiens	240-245
23220287-8	2013	Participants with a combination of low GFR (&lt;60 mL/min/1.72 m(2)) and high KIM-1/creatinine (&gt;128 ng/mmol) had a 3-fold increase in heart failure risk compared with participants with normal GFR and KIM-1 (P &lt; 0.001).	Creatinine	84-94	hepatitis A virus cellular receptor 1	Homo sapiens	78-83
23152298-9	2013	In adriamycin-induced nephropathic mice, sEH inhibitor did not ameliorate proteinuria or level of serum albumin but reduced the long-term elevated serum creatinine level, interstitial inflammation, fibrosis, and alpha-SMA expression.	Creatinine	153-163	epoxide hydrolase 2, cytoplasmic	Mus musculus	41-44
22889713-1	2013	BACKGROUND: Glomerular filtration rate (GFR) is a measure of kidney function, commonly estimated using equations that adjust serum creatinine concentration for age, race, and sex.	Creatinine	131-141	Rap guanine nucleotide exchange factor 5	Homo sapiens	40-43
22889713-3	2013	The serum creatinine-based Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI(cr)) equation generally provides more accurate estimation at GFR &gt;60 mL/min/1.73 m(2).	Creatinine	10-20	Rap guanine nucleotide exchange factor 5	Homo sapiens	147-150
23041245-7	2013	Absolute U-NGAL increased linearly with U-Cr concentration (the theoretical basis for creatinine adjustment) in the older males (R=0.19, P&lt;0.001) and with borderline significance in the young adults (R=0.16, P=0.08).	Creatinine	86-96	lipocalin 2	Homo sapiens	11-15
23041245-8	2013	The U-NGAL/Cr ratio was, however, negatively associated with creatinine in the older males (R=-0.14, P&lt;0.01) and in the young adults (R=-0.16, P=0.07) indicating a slight "overadjustment."	Creatinine	61-71	lipocalin 2	Homo sapiens	6-10
23324582-6	2013	RESULTS: Urinary NGAL level significantly correlated with the serum creatinine at presentation (r=0.762, p&lt;0.0001) but not baseline serum creatinine.	Creatinine	68-78	lipocalin 2	Homo sapiens	17-21
18209407-8	2002	Serum creatinine concentrations were associated with the increased plasma RBP indicating that RBP may be dependent on renal function and changes in levels of RBP in serum may be used in the assessment of renal function.	Creatinine	6-16	retinol binding protein 4	Homo sapiens	74-77
18209407-8	2002	Serum creatinine concentrations were associated with the increased plasma RBP indicating that RBP may be dependent on renal function and changes in levels of RBP in serum may be used in the assessment of renal function.	Creatinine	6-16	retinol binding protein 4	Homo sapiens	94-97
18209407-8	2002	Serum creatinine concentrations were associated with the increased plasma RBP indicating that RBP may be dependent on renal function and changes in levels of RBP in serum may be used in the assessment of renal function.	Creatinine	6-16	retinol binding protein 4	Homo sapiens	94-97
23413884-13	2013	Urinary protein excretion and serum creatinine levels were more elevated in the NGAL-positive group, but the difference was not significant.	Creatinine	36-46	lipocalin 2	Homo sapiens	80-84
11488674-5	2001	RESULTS: Urine EPX and serum ECP concentrations were significantly higher in patients with severe atopic dermatitis than in patients with mild or moderate disease (median values 123.5 vs 78.3 microg/mmol creatinine, P&lt;0.0001; 25.4 vs 14.9 microg/l, P&lt;0.0001, respectively).	Creatinine	204-214	ribonuclease A family member 3	Homo sapiens	29-32
11472438-9	2001	Only sTM was significantly lower in patients with both LAC and thrombosis than in patients without both these features after adjustment for serum creatinine concentrations.	Creatinine	146-156	sulfotransferase family 1A member 3	Homo sapiens	5-8
11499837-4	2001	ICAM-1+ interstitial leucocytes were correlated with glomerular sclerosis involving less than 50% of glomerular area, glomerular sclerosis involving more than 50% of glomerular area, tubular atrophy, interstitial fibrosis and serum creatinine level.	Creatinine	232-242	intercellular adhesion molecule 1	Homo sapiens	0-6
11499837-6	2001	In non-GN, ICAM-1+ tubule epithelium was 0.02+/-0.04 (U=344, P&lt;0.05, vs IgAN), and this was inversely correlated with the percentage of the normal glomeruli and associated with glomerular sclerosis covering more than 50% of glomerular area, tubular atrophy and serum creatinine level.	Creatinine	270-280	intercellular adhesion molecule 1	Homo sapiens	11-17
11386930-12	2001	Mean creatinine clearance increased by 2.1 mL/min (0.4 mL/s) for patients receiving alpha-gal A vs a decrease of 16.1 mL/min (0.3 mL/s) for placebo (P =.02).	Creatinine	5-15	galactosidase alpha	Homo sapiens	84-95
11306379-4	2001	MMP-2 and MMP-9 excretion in urine samples was measured with gelatin zymography and related to the urine creatinine concentration.	Creatinine	105-115	matrix metallopeptidase 9	Homo sapiens	10-15
11306379-6	2001	RESULTS: The upper cutoff limit for MMP-2 and MMP-9 excretion was 277 microg/g creatinine and 648 microg/g creatinine, respectively.	Creatinine	79-89	matrix metallopeptidase 9	Homo sapiens	46-51
23889308-4	2001	A statistically significant increase was also observed for urinary NAG activity in exposed workers who had urinary cadmium concentrations &gt; 2 mug g(-1) creatinine.	Creatinine	155-165	NBAS subunit of NRZ tethering complex	Homo sapiens	67-70
11076886-8	2000	In contrast, urinary CNP was higher in patients with impaired renal function compared with those with normal renal function and healthy controls (47.2 (7.4) v. 20.8 (1.9) and 17.0 (3.0) ng CNP/g creatinine, respectively; p&lt;0.05).	Creatinine	195-205	natriuretic peptide C	Homo sapiens	21-24
11076886-11	2000	In cirrhotic patients with hepatorenal syndrome or refractory ascites (n=5), urinary CNP decreased from 132 (59) to 38 (7) ng/g creatinine (p&lt;0.05) one week after either ornipressin infusion or insertion of a transjugular intrahepatic portosystemic shunt together with an increase in urinary sodium excretion from 27 (17) to 90 (34) mmol/24 hours.	Creatinine	128-138	natriuretic peptide C	Homo sapiens	85-88
11118085-6	2000	RESULTS: There were significant improvements in serum creatinine and blood urea nitrogen at 24 hr in the NA-NP group when compared with the IC group (P&lt;0.05).	Creatinine	54-64	N-acetylneuraminic acid phosphatase	Rattus norvegicus	105-110
22859744-8	2012	By linear regression analysis, whole-urine TGFbeta, L1CAM, and urinary protein-to-creatinine ratio were associated with low GFR in the case-patients.	Creatinine	82-92	Rap guanine nucleotide exchange factor 5	Homo sapiens	124-127
22745276-8	2012	Renal function (analyzed by serum creatinine levels) at the first week posttransplantation correlated with kidney injury molecule-1 and forkhead box P3 mRNA levels.	Creatinine	34-44	hepatitis A virus cellular receptor 1	Homo sapiens	107-131
22976261-7	2012	There were significant inverse correlations between urine NGAL and estimated creatinine clearance in the FSGS patients both at diagnosis (r = -0.589, P = .03), and after 1 year (r = -0.76, P = .009).	Creatinine	77-87	lipocalin 2	Homo sapiens	58-62
22859854-6	2012	Chimeric CD47-knockout mice engrafted with wild-type hematopoietic cells had significantly lower serum creatinine and less tubular damage than wild-type controls after IRI, suggesting that CD47 signaling in parenchymal cells predominantly mediates renal damage.	Creatinine	103-113	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	9-13
22859854-6	2012	Chimeric CD47-knockout mice engrafted with wild-type hematopoietic cells had significantly lower serum creatinine and less tubular damage than wild-type controls after IRI, suggesting that CD47 signaling in parenchymal cells predominantly mediates renal damage.	Creatinine	103-113	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	189-193
22743139-10	2012	Urinary CNP excretion was negatively correlated with urinary protein concentration, blood urea nitrogen and creatinine, while positively correlated with albumin.	Creatinine	108-118	natriuretic peptide C	Rattus norvegicus	8-11
21695423-7	2012	The association of KL genotypes with creatinine levels was found only in females, while the association with insulin-like growth factor-1 (IGF-1) and lymphocytes count (LC) was found only in males.	Creatinine	37-47	klotho	Homo sapiens	19-21
21695423-9	2012	Our findings suggested that KL locus may influence quantitative traits such as serum levels of lipid, fasting glucose, albumin and hemoglobin in hospitalized older patients, with some gender differences suggested for creatinine, IGF-1 levels, and LC, thus being one of the genetic factors possibly contributing to age-related diseases and longevity.	Creatinine	217-227	klotho	Homo sapiens	28-30
21366514-6	2012	RESULTS: Natural logarithm of the urinary AGT/creatinine (ln (urinary AGT/Cr)) was positively correlated with intrarenal expression of AGT (ln (urinary AGT/Cr) versus AGT/beta-actin, r = 0.620, P &lt; 0.0001; ln (urinary AGT/Cr) versus AGT density, r = 0.452, P = 0.007).	Creatinine	46-56	POTE ankyrin domain family member F	Homo sapiens	171-181
22448714-8	2012	RESULTS: Pre-operative surface expression of CD99 and CD47 correlates with post-operative creatinine levels (P &lt; 0 05), a measurement of renal injury.	Creatinine	90-100	CD47 molecule	Homo sapiens	54-58
22733458-10	2012	CT-1-treated rats presented unaltered serum creatinine concentrations but increased urinary and serum neutrophile gelatinase-associated lipocalin and microalbuminuria/creatininuria ratio.	Creatinine	44-54	cardiotrophin 1	Rattus norvegicus	0-4
22703926-8	2012	RESULTS: Both lower estimated glomerular filtration rate and higher urine albumin to creatinine ratios were associated with high FGF-23 at baseline.	Creatinine	85-95	fibroblast growth factor 23	Homo sapiens	129-135
22779070-10	2012	Short-term outcomes of ABO-incompatible kidney transplantation (measured as creatinine levels) after reducing anti-A/B antibody titers were similar to those of ABO-compatible kidney transplantation.	Creatinine	76-86	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	23-26
21895733-7	2012	RESULTS: Chemerin levels correlated with body mass index (BMI), waist circumference, abdominal visceral fat area, blood pressure, fasting insulin, homoeostasis model of assessment-insulin resistance, total cholesterol, triglyceride, creatinine, aspartate aminotransferase and alanine aminotransferase.	Creatinine	233-243	retinoic acid receptor responder 2	Homo sapiens	9-17
22670778-7	2012	In the pre-eclamptic group, plasma ficolin-2 levels showed a significant positive correlation with serum placental growth factor (PlGF) concentrations and significant inverse correlations with serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1), blood urea nitrogen and creatinine, serum lactate dehydrogenase activities, as well as with plasma VWF:antigen, fibronectin and cell-free fetal DNA concentrations.	Creatinine	278-288	ficolin 2	Homo sapiens	35-44
22759853-30	2012	Furthermore, the positive results from study II and III on precision and biological variation indicate that CysC, creatinine and BCM are very stable variables, which is an indirect validation of the BCM-model s precision and validity.	Creatinine	114-124	TNF receptor superfamily member 17	Homo sapiens	199-202
10718343-4	2000	In the diabetic mice, HGF reduced creatinine clearance and increased microalbuminuria, indicating that chronic exposure to HGF impairs renal function.	Creatinine	34-44	hepatocyte growth factor	Mus musculus	22-25
10718343-4	2000	In the diabetic mice, HGF reduced creatinine clearance and increased microalbuminuria, indicating that chronic exposure to HGF impairs renal function.	Creatinine	34-44	hepatocyte growth factor	Mus musculus	123-126
22442208-7	2012	In those patients who had not received immunosuppressive treatment before biopsy, serum creatinine levels were positively correlated with tubulointerstitial IL-17(+) neutrophils as well as IL-17(+) T cells.	Creatinine	88-98	interleukin 17A	Homo sapiens	157-162
10754409-7	2000	In a HUS patient, the increase in serum IL-10 and endothelin levels reached a plateau prior to the peak of serum creatinine levels.	Creatinine	113-123	interleukin 10	Homo sapiens	40-45
22442208-7	2012	In those patients who had not received immunosuppressive treatment before biopsy, serum creatinine levels were positively correlated with tubulointerstitial IL-17(+) neutrophils as well as IL-17(+) T cells.	Creatinine	88-98	interleukin 17A	Homo sapiens	189-194
22121231-9	2012	eNOS gene delivery also reduced a rise in serum creatinine, urinary ET-1 excretion and renal cortex ET-1 levels, and the renal vascular, glomerular and tubular injury.	Creatinine	48-58	nitric oxide synthase 3	Rattus norvegicus	0-4
22223530-4	2012	RESULTS: Compared with wild-type mice, creatinine clearance was significantly impaired in Oct1/2(-/-) mice.	Creatinine	39-49	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	90-101
22173699-1	2012	Serum levels of creatinine, cystatin C, or beta trace protein allow estimation of GFR, but whether these markers contribute additional prognostic information beyond that reflected in GFR is unknown.	Creatinine	16-26	Rap guanine nucleotide exchange factor 5	Homo sapiens	82-85
10620205-6	2000	Median urinary RBP levels in mg/mmol creatinine were: affected male Dent"s, 18.2, N = 26; carrier female Dent"s, 0.	Creatinine	37-47	retinol binding protein 4	Homo sapiens	15-18
22173699-5	2012	After adjustment for GFR in a Cox proportional hazards model, higher creatinine associated with a higher risk for kidney failure but a lower risk for all-cause mortality.	Creatinine	69-79	Rap guanine nucleotide exchange factor 5	Homo sapiens	21-24
22467319-4	2012	Concentration of cathepsin B in urine was adjusted on creatinine.	Creatinine	54-64	cathepsin B	Homo sapiens	17-28
22467319-8	2012	Similarly, the ratio of U-cathepsin B/creatinine was significantly higher in patients (Median: 0.44 mug/mmol creatinine vs. 0.17 mug/mmol creatinine, P &lt; 0.0001).	Creatinine	109-119	cathepsin B	Homo sapiens	26-37
22467319-8	2012	Similarly, the ratio of U-cathepsin B/creatinine was significantly higher in patients (Median: 0.44 mug/mmol creatinine vs. 0.17 mug/mmol creatinine, P &lt; 0.0001).	Creatinine	109-119	cathepsin B	Homo sapiens	26-37
22467319-9	2012	U-cathepsin B may prove to be useful biomarker (area under the curve [AUC] = 0.72 and 0.73 for the U-cathepsin B/creatinine ratio, respectively).	Creatinine	113-123	cathepsin B	Homo sapiens	2-13
22467319-12	2012	New index U-cathepsin B/Creatinine ratio is more appropriate biomarker to monitor TCC, than U-cathepsin B so far.	Creatinine	24-34	cathepsin B	Homo sapiens	12-23
22710867-7	2012	There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041).	Creatinine	62-72	aldehyde dehydrogenase 7 family member A1	Homo sapiens	102-105
22710867-7	2012	There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041).	Creatinine	189-199	aldehyde dehydrogenase 7 family member A1	Homo sapiens	216-219
20890648-3	2011	Injection of CCl4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl4 injection, suggesting that radon inhalation alleviates CCl4-induced hepatic and renal damage.	Creatinine	153-163	chemokine (C-C motif) ligand 4	Mus musculus	13-17
10659549-4	1999	The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm Creatinine respectively.	Creatinine	86-96	dihydropyrimidine dehydrogenase	Homo sapiens	23-26
10527953-6	1999	Increases in serum creatinine and blood urea nitrogen 24 h after reperfusion were attenuated by 35% (p&lt; 0.01) and by 53% (p&lt; 0.001), respectively, in FGF-1-treated animals compared to vehicle-treated rats.	Creatinine	19-29	fibroblast growth factor 1	Rattus norvegicus	156-161
10404695-4	1999	Two by two hour creatinine clearance provided a measurement of GFR as valid as 24-h creatinine clearance.	Creatinine	16-26	Rap guanine nucleotide exchange factor 5	Homo sapiens	63-66
20890648-3	2011	Injection of CCl4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl4 injection, suggesting that radon inhalation alleviates CCl4-induced hepatic and renal damage.	Creatinine	261-271	chemokine (C-C motif) ligand 4	Mus musculus	13-17
22172823-10	2011	There was a positive correlation between TIM-3 mRNA expression and serum creatinine (r2=0.716; P=.00).	Creatinine	73-83	hepatitis A virus cellular receptor 2	Homo sapiens	41-46
22117111-9	2011	A stepwise regression analysis showed that the serum chemerin levels significantly and positively correlated with systolic blood pressure (P&lt;0.001), free fatty acids (P&lt;0.05) and serum creatinine (P&lt;0.01).	Creatinine	191-201	retinoic acid receptor responder 2	Homo sapiens	53-61
21997818-12	2011	Peak AST, H-FABP, and NGAL correlated with peak creatinine [Pearson coefficients: 0.70 (P = 0.001), 0.85 (P &lt; 0.0001), 0.80 (P &lt; 0.0001)].	Creatinine	48-58	lipocalin 2	Homo sapiens	22-26
21846754-5	2011	Urinary analysis showed that KIM-1 was significantly elevated in heart failure patients compared with healthy controls (1100, IQR 620-1920 vs. 550, IQR 320-740 ng/g urinary creatinine, P &lt; 0.001).	Creatinine	173-183	hepatitis A virus cellular receptor 1	Homo sapiens	29-34
21870328-7	2011	Moreover, the expression of nephrin and ACTN4 negatively correlated with creatinine.	Creatinine	73-83	actinin alpha 4	Canis lupus familiaris	40-45
21402675-7	2011	Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance.	Creatinine	75-85	hepatitis A virus cellular receptor 1	Homo sapiens	18-23
21402675-7	2011	Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance.	Creatinine	122-132	hepatitis A virus cellular receptor 1	Homo sapiens	18-23
21646940-8	2011	We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories.	Creatinine	66-68	lipocalin 2	Homo sapiens	20-24
21646940-8	2011	We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories.	Creatinine	221-231	interleukin 18	Homo sapiens	177-182
21646940-9	2011	Controlling for other potential clinical and demographic confounders with regression analysis shows that NGAL/cr, OPN/cr, and B2mG/cr are independently associated with GA. We conclude that urine values of candidate AKI biomarkers are higher in the most premature infants.	Creatinine	110-112	lipocalin 2	Homo sapiens	105-109
21813009-10	2011	The plasma creatinine level had the greatest area under the ROC curve (AUC): 0.83 (95% confidence interval 0.74-0.92), significantly better than the AUCs for, urinary sodium level, the urea to creatinine ratio (UCR), the fractional excretion of urea (FeUN) and the urinary neutrophil gelatinase-associated lipocalcin (NGAL) level.	Creatinine	11-21	lipocalin 2	Homo sapiens	273-316
21813009-10	2011	The plasma creatinine level had the greatest area under the ROC curve (AUC): 0.83 (95% confidence interval 0.74-0.92), significantly better than the AUCs for, urinary sodium level, the urea to creatinine ratio (UCR), the fractional excretion of urea (FeUN) and the urinary neutrophil gelatinase-associated lipocalcin (NGAL) level.	Creatinine	11-21	lipocalin 2	Homo sapiens	318-322
22291802-8	2011	Serum NGAL correlated with age, haematocrit, leukocyte, platelet and erythrocyte count, eGFR, creatinine, fasting glucose, HbA(1c), fibrinogen, SBP, and diabetes duration.	Creatinine	94-104	lipocalin 2	Homo sapiens	6-10
22291802-9	2011	In multiple regression analysis kidney function (eGFR, creatinine clearance or creatinine), cystatin C and SBP were predictors of serum NGAL.	Creatinine	55-65	lipocalin 2	Homo sapiens	136-140
22291802-9	2011	In multiple regression analysis kidney function (eGFR, creatinine clearance or creatinine), cystatin C and SBP were predictors of serum NGAL.	Creatinine	79-89	lipocalin 2	Homo sapiens	136-140
21412214-9	2011	In logistic regression analysis, NGAL independently predicted the composite outcome when corrected for demographics, comorbidities, creatinine, and RIFLE class.	Creatinine	132-142	lipocalin 2	Homo sapiens	33-37
21521262-11	2011	In all subjects (n = 51), creatinine and TTR (P &lt; 0 05) but not adipose RBP4 mRNA were associated with plasma RBP4.	Creatinine	26-36	retinol binding protein 4	Homo sapiens	113-117
21521262-12	2011	Plasma RBP4 but not its adipose expression was in turn associated positively (P &lt; 0 05) with CRP independently of creatinine-TTR.	Creatinine	117-127	retinol binding protein 4	Homo sapiens	7-11
21569589-8	2011	In univariate analysis, concentrations of RBP and protein HC in urine were significantly correlated with both U-Cd and B-Cd but these associations were substantially weakened by the adjustment for current smoking and the residual influence of diuresis after correction for urinary creatinine.	Creatinine	281-291	retinol binding protein 4	Homo sapiens	42-45
21183928-8	2011	RESULTS: As a result of infusion of recombinant VEGF(121) autoantibody-induced hypertension (systolic blood pressure) was reduced from 159 +- 5 to 124 +- 5 mm Hg, proteinuria from 111 +- 16 to 40 +- 5 mg protein/mg creatinine and blood urea nitrogen levels from 31 +- 1 mg/dl to 18 +- 2 mg/dl, P &lt; 0.05.	Creatinine	215-225	vascular endothelial growth factor A	Mus musculus	48-52
21394006-7	2011	After 24 h, TLR4 inhibition had significantly (P &lt;= 0.001) attenuated the mean +- SEM decrease in arterial pressure (97 +- 3 vs. 71 +- 4 mmHg), urine output (1.16 +- 0.15 vs. 0.13 +- 0.05 ml   kg(-1)   h(-1)), and creatinine clearance (126 +- 13 vs. 20 +- 7 ml/min) compared with vehicle-treated animals.	Creatinine	217-227	toll-like receptor 4	Ovis aries	12-16
21793271-9	2011	Blood levels of AST and ALT were not significantly different from the control group but urea and creatinine levels were lower in groups Exp3 and Exp1.	Creatinine	97-107	exportin 1	Rattus norvegicus	145-149
21124314-2	2011	hOCT2 showed a prominent uptake of creatinine (K(m) = 56.4 mmol/l) among renal organic ion transporters.	Creatinine	35-45	POU class 2 homeobox 2	Homo sapiens	0-5
21124314-4	2011	The pharmacokinetic model involving the inhibition of hOCT2 (model 1), hOCT2, and MATE1 or MATE2-K (model 2) could predict the elevation in serum creatinine levels in individual subjects receiving DX-619.	Creatinine	146-156	POU class 2 homeobox 2	Homo sapiens	54-59
21124314-4	2011	The pharmacokinetic model involving the inhibition of hOCT2 (model 1), hOCT2, and MATE1 or MATE2-K (model 2) could predict the elevation in serum creatinine levels in individual subjects receiving DX-619.	Creatinine	146-156	solute carrier family 47 member 1	Homo sapiens	82-87
21124314-6	2011	In conclusion, DX-619, at its therapeutic dose, is able to inhibit hOCT2, hMATE1, and hMATE2-K, leading to a significant inhibition of tubular secretion of creatinine and consequently to elevation of serum creatinine levels.	Creatinine	156-166	POU class 2 homeobox 2	Homo sapiens	67-72
21178528-7	2011	An indexed urinary gamma-glutamyl transpeptidase-to-urinary creatinine ratio was significantly increased in the patients with acute kidney injury and did not correlate with plasma creatinine (p = .3).	Creatinine	60-70	inactive glutathione hydrolase 2	Homo sapiens	19-48
21291554-1	2011	INTRODUCTION: The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CLCR) in a population of polytrauma patients (PT) through a comparison with a population of non trauma patients (NPT).	Creatinine	146-156	chymotrypsin C	Homo sapiens	168-172
21291554-12	2011	CONCLUSIONS: In ICU patients with normal serum creatinine, CLCR, is higher in PT than in NPT.	Creatinine	47-57	chymotrypsin C	Homo sapiens	59-63
21545740-7	2011	Donor S-NGAL and U-NGAL concentrations correlated directly with donor plasma creatinine levels and indirectly with estimated glomerular filtration rate (eGFR) calculated using the modification of diet in renal disease equation for glomerular filtration rate.	Creatinine	77-87	lipocalin 2	Homo sapiens	8-12
21545740-7	2011	Donor S-NGAL and U-NGAL concentrations correlated directly with donor plasma creatinine levels and indirectly with estimated glomerular filtration rate (eGFR) calculated using the modification of diet in renal disease equation for glomerular filtration rate.	Creatinine	77-87	lipocalin 2	Homo sapiens	19-23
21102325-6	2011	Whenever renal damage occurred, as evidenced by histopathology or subsequent increase in serum creatinine levels, NGAL levels were higher than in patients without acute renal disease.	Creatinine	95-105	lipocalin 2	Homo sapiens	114-118
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	mucin 16, cell surface associated	Homo sapiens	146-151
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	mucin 16, cell surface associated	Homo sapiens	222-227
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	bone morphogenetic protein 7	Homo sapiens	229-234
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	bone morphogenetic protein 7	Homo sapiens	240-244
21755056-9	2011	Patients with dialysate/plasma creatinine  0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P &lt; .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.	Creatinine	31-41	mucin 16, cell surface associated	Homo sapiens	222-227
21512281-12	2011	The ALP activity induced in RAGE-overexpressing HASMCs by human serum was positively correlated with the serum creatinine level, but not with phosphate and hemoglobin A1c levels.	Creatinine	111-121	advanced glycosylation end-product specific receptor	Homo sapiens	28-32
20844835-6	2011	In comparison with the Ad-GFP group, the Ad-ACE2 group exhibited reduced systolic blood pressure, urinary albumin excretion, creatinine clearance, glomeruli sclerosis index and renal malondialdehyde level; downregulated transforming growth factor (TGF)-beta1, vascular endothelial growth factor (VEGF) and collagen IV protein expression; and increased renal superoxide dismutase activity.	Creatinine	125-135	angiotensin I converting enzyme 2	Rattus norvegicus	44-48
20446811-5	2011	Our results revealed that serum creatinine and urea nitrogen levels decreased to the baseline more quickly in HGF-hucMSCs-treated group than that in hucMSCs- or green fluorescent protein-hucMSCs-treated groups at 72 h after injury.	Creatinine	32-42	hepatocyte growth factor	Rattus norvegicus	110-113
20844024-1	2010	The screening for chronic kidney diseases (CKD) patients with impaired GFR needs the measurement of serum creatinine (SCr) or cystatin C (SCys).	Creatinine	106-116	Rap guanine nucleotide exchange factor 5	Homo sapiens	71-74
20538296-17	2010	Administration of human AM/AMBP-1 decreased renal water content, and plasma levels of creatinine, BUN, AST, and ALT.	Creatinine	86-96	adrenomedullin	Homo sapiens	24-26
20538296-17	2010	Administration of human AM/AMBP-1 decreased renal water content, and plasma levels of creatinine, BUN, AST, and ALT.	Creatinine	86-96	complement factor H	Homo sapiens	27-33
20368304-8	2010	FGF23 levels positively correlated to calcium (r = 0.27, P &lt; 0.0001), phosphate (r = 0.40, P &lt; 0.0001), calcium x phosphate product (r = 0.52, P &lt; 0.0001) and creatinine (r = 0.18, P = 0.007).	Creatinine	168-178	fibroblast growth factor 23	Homo sapiens	0-5
20406131-4	2010	RESULTS: Plasma NGAL concentrations were associated with patient age (R(s)=0.2055, p=0.0144), plasma homocysteine (R(s)=0.4274, p&lt;0.00001) and serum creatinine (R(s)=0.4640, p&lt;0.00001) concentrations and estimated glomerular filtration rate (eGFR) (R(s)=-0.4911, p&lt;0.00001).	Creatinine	152-162	lipocalin 2	Homo sapiens	16-20
20406131-8	2010	CONCLUSIONS: Plasma NGAL concentrations were associated with patient age, hypertension, eGFR, creatinine and homocysteine concentrations and therapy with ACE inhibitors.	Creatinine	94-104	lipocalin 2	Homo sapiens	20-24
20131076-14	2010	Moreover, a significant positive correlation was observed between the number of interstitial MCs, the expression of SCF, PAR-2 and alpha-SMA and the serum creatinine level (r = 0.738 for MCs, r = 0.658 for alpha-SMA, r = 0.692 for PAR-2, r = 0.754 for SCF, P &lt; 0.05).	Creatinine	155-165	KIT ligand	Homo sapiens	116-119
20131076-14	2010	Moreover, a significant positive correlation was observed between the number of interstitial MCs, the expression of SCF, PAR-2 and alpha-SMA and the serum creatinine level (r = 0.738 for MCs, r = 0.658 for alpha-SMA, r = 0.692 for PAR-2, r = 0.754 for SCF, P &lt; 0.05).	Creatinine	155-165	KIT ligand	Homo sapiens	252-255
20448068-0	2010	The CKD-EPI equation for estimating GFR from serum creatinine: real improvement or more of the same?	Creatinine	51-61	Rap guanine nucleotide exchange factor 5	Homo sapiens	36-39
20610143-6	2010	Serum RBP4 levels of all subjects were positively correlated with total cholesterol, triglyceride, creatinine, insulin resistance and albumin, and inversely correlated with aspartate aminotransferase and alanine aminotransferase.	Creatinine	99-109	retinol binding protein 4	Homo sapiens	6-10
20363918-4	2010	In this study, in a Fischer to Lewis rat renal transplantation model, administration of the PPARgamma-agonist, rosiglitazone, independent of dose (3 or 30 mg/kgBW/day), lowered serum creatinine, albuminuria, and chronic allograft damage with a chronic vascular damage score as follows: 35.0 +/- 5.8 (controls) vs. 8.1 +/- 2.4 (low dose-Rosi; P &lt; 0.05); chronic tubulointerstitial damage score: 13.6 +/- 1.8 (controls) vs. 2.6 +/- 0.4 (low dose-Rosi; P &lt; 0.01).	Creatinine	183-193	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	92-101
20363104-11	2010	A significant correlation was found between plasma NGAL at 4 hr and the change in serum creatinine (r = 0.863, p = 0.006) as well as ventilation duration (r = 0.830, p = 0.011).	Creatinine	88-98	lipocalin 2	Homo sapiens	51-55
20089675-3	2010	Inhibition of endogenous TK levels for 10 days by neutralizing TK antibody injection in DOCA-salt rats caused a significant increase in blood urea nitrogen and urinary protein levels, and a decrease in creatinine clearance.	Creatinine	202-212	kallikrein 1-related peptidase C12	Rattus norvegicus	25-27
20089675-3	2010	Inhibition of endogenous TK levels for 10 days by neutralizing TK antibody injection in DOCA-salt rats caused a significant increase in blood urea nitrogen and urinary protein levels, and a decrease in creatinine clearance.	Creatinine	202-212	kallikrein 1-related peptidase C12	Rattus norvegicus	63-65
20007677-5	2010	In contrast, urine netrin-1 increased at 2 hours after CPB, peaked at 6 hours (2462 +/- 370 pg/mg creatinine), and remained elevated up to 48 hours after CPB.	Creatinine	98-108	netrin 1	Homo sapiens	19-27
20110343-6	2010	RESULTS: Creatinine clearance overestimated iGFR.	Creatinine	9-19	insulin like growth factor 1 receptor	Homo sapiens	44-48
19956924-11	2010	Septic AKI was associated with significantly higher plasma (293 vs. 166 ng/ml) and urine (204 vs. 39 ng/mg creatinine) NGAL at enrollment compared with non-septic AKI (p &lt; 0.001).	Creatinine	107-117	lipocalin 2	Homo sapiens	119-123
19938135-11	2009	In patients with creatinine concentrations less than 1.5 mg/dL, a single NGAL determination 2 hours after reperfusion of the liver was associated with the development of AKI.	Creatinine	17-27	lipocalin 2	Homo sapiens	73-77
19709697-7	2009	Pearson correlations revealed that serum RBP4 level correlated positively with age, waist circumference, waist-to-hip ratio, systolic blood pressure, total cholesterol, triglyceride, uric acid, creatinine, and urine albumin-to-creatinine ratio.	Creatinine	194-204	retinol binding protein 4	Homo sapiens	41-45
19709697-7	2009	Pearson correlations revealed that serum RBP4 level correlated positively with age, waist circumference, waist-to-hip ratio, systolic blood pressure, total cholesterol, triglyceride, uric acid, creatinine, and urine albumin-to-creatinine ratio.	Creatinine	227-237	retinol binding protein 4	Homo sapiens	41-45
19709697-9	2009	Multiple linear regression analysis with serum RBP4 level as the dependent variable revealed that total cholesterol, triglyceride, uric acid, and albumin-to-creatinine ratio correlated independently and positively with serum RBP4 level and that estimated glomerular filtration rate correlated independently and negatively with serum RBP4 level.	Creatinine	157-167	retinol binding protein 4	Homo sapiens	47-51
19715672-4	2009	MafA(-/-)MafK(+) mice developed severe overt diabetes mellitus within 5weeks old, and showed higher levels of proteinuria and serum creatinine.	Creatinine	132-142	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	9-13
19729431-3	2009	DESIGN, SETTING, PARTICIPANTS, &amp; MEASUREMENTS: A one-compartment pharmacokinetic model of creatinine change resulting from a decrease in GFR was applied to a population of 10,000 simulated virtual inpatients.	Creatinine	94-104	Rap guanine nucleotide exchange factor 5	Homo sapiens	141-144
19820136-3	2009	Creatinine clearance-based estimates of GFR are often used in pediatrics.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	40-43
19820136-4	2009	The addition of cimetidine to eliminate creatinine secretion permits accurate measurement of GFR in those who can completely empty their bladders to provide timed urine collections.	Creatinine	40-50	Rap guanine nucleotide exchange factor 5	Homo sapiens	93-96
19820136-7	2009	GFR estimating equations, based on serum concentrations of creatinine or cystatin C, are popular clinically and in research studies.	Creatinine	59-69	Rap guanine nucleotide exchange factor 5	Homo sapiens	0-3
19474273-4	2009	RESULTS: The predictive value of plasma NGAL varied according to the AKI definition used and was higher for more severe AKI (increase in creatinine &gt;50%: mean AUC-ROC 0.79 +/- 0.01) compared to less severe AKI (&gt;25%: mean AUC-ROC 0.65 +/- 0.02); P = 0.001.	Creatinine	137-147	lipocalin 2	Homo sapiens	40-44
19696627-4	2009	The aim of this study was to investigate the expression of CD55 in renal allografts and to correlate it with the expression of C4d, allograft survival, changes in serum creatinine (SC).	Creatinine	169-179	CD55 molecule (Cromer blood group)	Homo sapiens	59-63
19899326-15	2009	Effects on markers of renal functions showed that CCl4-intoxication significantly (p &lt; 0.05) elevated serum urea and creatinine by 287 and 186%, respectively.	Creatinine	120-130	chemokine (C-C motif) ligand 4	Mus musculus	50-54
19522876-8	2009	Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p &lt; 0.001) and 1 year (p &lt; 0.05) after kidney transplantation.	Creatinine	124-134	hepatitis A virus cellular receptor 1	Homo sapiens	49-54
19390997-7	2009	Moreover, urine NGAL was found to be correlated positively with cystatin C, urea nitrogen, and serum creatinine (SCr), and inversely with glomerular filtration rate (GFR), while serum NGAL correlated negatively with cystatin C and urea nitrogen, at both baseline and follow-up levels.	Creatinine	101-111	lipocalin 2	Homo sapiens	16-20
19361453-6	2009	The urine levels of HNL/NGAL showed a weak, but significant relation with kidney function as measured by plasma levels of cystatin C or creatinine.	Creatinine	136-146	lipocalin 2	Homo sapiens	24-28
19302753-6	2009	RESULTS: The level of HMGB1 had a positive, high correlation with the abnormal changes of serum cardiac troponin I, alanine aminotransferase, aspartate aminotransferase, creatinine and blood urea nitrogen, as well as the pathologic scores of heart, lung, liver and kidney.	Creatinine	170-180	high mobility group box 1	Rattus norvegicus	22-27
19517296-1	2009	BACKGROUND: Serum creatinine-based estimates of GFR may be inaccurate in the elderly and there is need for improvement.	Creatinine	18-28	Rap guanine nucleotide exchange factor 5	Homo sapiens	48-51
19517296-10	2009	Estimated GFR using the MDRD Study equations (creatinine based) showed accuracy of 94% with 4 or 6 factors used.	Creatinine	46-56	Rap guanine nucleotide exchange factor 5	Homo sapiens	10-13
19249501-9	2009	Before transplantation, serum NGAL was related to creatinine and cystatin C.	Creatinine	50-60	lipocalin 2	Homo sapiens	30-34
19249501-10	2009	At each time point, serum NGAL was related positively to serum creatinine, cystatin C, and negatively to urine volume.	Creatinine	63-73	lipocalin 2	Homo sapiens	26-30
19249502-7	2009	In univariate analysis serum NGAL was related to serum creatinine, hemoglobin, hematocrit, leukocyte count, and eGFR.	Creatinine	55-65	lipocalin 2	Homo sapiens	29-33
19249502-8	2009	Predictors of serum NGAL were creatinine and eGFR among patients with CKD.	Creatinine	30-40	lipocalin 2	Homo sapiens	20-24
19249502-9	2009	On univariate analysis serum NGAL was related to serum creatinine, urea, hemoglobin, hematocrit, white blood cell count, calcineurin concentration, eGFR, and albumin in kidney transplant recipients.	Creatinine	55-65	lipocalin 2	Homo sapiens	29-33
19249502-10	2009	On multiple regression analysis, predictors of NGAL were creatinine, calcineurin concentration, and high-sensitivity C-reactive protein.	Creatinine	57-67	lipocalin 2	Homo sapiens	47-51
19249502-11	2009	In healthy volunteers, serum NGAL correlated with age, serum creatinine, eGFR, and leukocyte count.	Creatinine	61-71	lipocalin 2	Homo sapiens	29-33
19768194-5	2009	In the last decade a new paradigm has been introduced in which the true or measured GFR is estimated (eGFR) by formulas based on serum creatinine levels and in which these estimates are applied to the diagnoses of chronic kidney disease (CKD) in the general population.	Creatinine	135-145	Rap guanine nucleotide exchange factor 5	Homo sapiens	84-87
18930752-8	2008	Creatinine secretion was by OCT2-mediated uptake at the basolateral membrane and via MDR1 at the apical membrane.	Creatinine	0-10	POU class 2 homeobox 2	Homo sapiens	28-32
18955901-5	2008	The findings made suggest that the NGAL balance is altered in patients with severe proteinuria who have not yet developed overt chronic renal failure, thus confirming the potential use of this protein as an early biomarker of kidney damage preceding the increase in serum creatinine levels.	Creatinine	272-282	lipocalin 2	Homo sapiens	35-39
19100415-7	2008	Upon multiple regression analysis the predictors of elevated CD44 were hsCRP concentration (beta = .25; P &lt; .05), CD146 (beta = .39; P &lt; .05), creatinine (beta = .55; P &lt; .01), and thrombomodulin (beta = .39; P &lt; .05) with an adjusted R(2) = .40 (F = 4.12; P &lt; .00028; SE of estimate = 151.19).	Creatinine	149-159	CD44 molecule (Indian blood group)	Homo sapiens	61-65
18804416-6	2008	Both serum creatinine (r=0.26, P=0.006) and eGFR (r=-0.29, P=0.002) were significantly associated with urinary NGAL levels as were NT-proBNP and UAE but to a lesser extent.	Creatinine	11-21	lipocalin 2	Homo sapiens	111-115
18803935-4	2008	The levels of plasma RBP-4 were increased by 1.4- and 3.3-fold in patients with renal disease with macroalbuminuria (P = .04) and end-stage renal disease (plasma creatinine level &gt;2.0 mg/dL) (P &lt; .0001) compared with those in patients with normal renal function.	Creatinine	162-172	retinol binding protein 4	Homo sapiens	21-26
18803935-5	2008	In addition, RBP-4 levels were correlated with the creatinine level and 24-hour creatinine clearance (Ccr) on simple and multiple regression analyses in all patients.	Creatinine	51-61	retinol binding protein 4	Homo sapiens	13-18
18803935-5	2008	In addition, RBP-4 levels were correlated with the creatinine level and 24-hour creatinine clearance (Ccr) on simple and multiple regression analyses in all patients.	Creatinine	80-90	retinol binding protein 4	Homo sapiens	13-18
18674408-7	2008	The model predicted that CL/F for subjects with creatinine clearance (CLCR) of 30 mL/min (moderate renal impairment) and of 50 mL/min (mild renal impairment) was 17% and 9.7% lower, respectively, relative to subjects with CLCR of 94 mL/min, the data set median value.	Creatinine	48-58	crooked neck pre-mRNA splicing factor 1	Homo sapiens	25-29
18579674-7	2008	HALT-Polycystic Kidney Disease (HALT-PKD) is designed to test whether blockade of RAAS and/or rigorous blood pressure control play a role in slowing renal progression during early (using magnetic resonance imaging methods developed in CRISP) and during late (using measures, including composite of time to doubling of serum creatinine, onset of end-stage renal disease, or death) phases in ADPKD.	Creatinine	324-334	protein kinase D1	Homo sapiens	37-40
18368027-6	2008	The area of either CD68 or DC-SIGN positive interstitial cells correlated with serum creatinine.	Creatinine	85-95	CD68 molecule	Homo sapiens	19-23
18493238-3	2008	KIM-1 levels showed positive correlation with serum creatinine and blood urea nitrogen levels, and inverse correlation with estimated glomerular filtration rate.	Creatinine	52-62	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
18223261-7	2008	RESULTS: Urinary alpha(2)-AP-resistant plasmin activity corrected for creatinine concentration (units/g x creatinine) was significantly higher in patients with APSGN (2.99 +/- 0.63) than in patients with IgAN (1.02 +/- 0.20, P &lt; 0.01), SI (0.79 +/- 0.17, P &lt; 0.01), or in healthy control subjects (0.73 +/- 0.18, P &lt; 0.01).	Creatinine	70-80	serpin family F member 2	Homo sapiens	17-28
18223261-7	2008	RESULTS: Urinary alpha(2)-AP-resistant plasmin activity corrected for creatinine concentration (units/g x creatinine) was significantly higher in patients with APSGN (2.99 +/- 0.63) than in patients with IgAN (1.02 +/- 0.20, P &lt; 0.01), SI (0.79 +/- 0.17, P &lt; 0.01), or in healthy control subjects (0.73 +/- 0.18, P &lt; 0.01).	Creatinine	106-116	serpin family F member 2	Homo sapiens	17-28
18400813-0	2008	Do we need another equation to estimate GFR from serum creatinine in renal allograft recipients?	Creatinine	55-65	Rap guanine nucleotide exchange factor 5	Homo sapiens	40-43
18519927-9	2008	RESULTS: Patients with acute kidney injury had a significantly elevated mean urinary NGAL level compared with the other kidney function groups (416 microg/g creatinine [SD, 387]; P = 0.001).	Creatinine	157-167	lipocalin 2	Homo sapiens	85-89
18253759-6	2008	Plasma C3 correlated positively with lipid parameters [triglyceride, cholesterol, LDL-C, apolipoprotein B (apoB), high-density lipoprotein cholesterol (HDL-C) and apoA1] and inversely with total protein, blood urea nitrogen, and creatinine.	Creatinine	229-239	complement C3	Homo sapiens	7-9
18956700-13	2008	(7) Urinary concentrations of NGAL at 2 h after cardiac surgery was significantly associated with serum creatinine 12 h postoperative (R = 0.638, P &lt; 0.05).	Creatinine	104-114	lipocalin 2	Homo sapiens	30-34
18396123-4	2008	After two weeks on enzyme replacement therapy (ERT) with idursulfase (IDS), the excretion of GAG was decreased to 36.2 ng/nmol/creatinine and the liver and spleen volumes were reduced to normal limits.	Creatinine	127-137	iduronate 2-sulfatase	Homo sapiens	57-68
18078816-4	2008	ZAG correlated with glucose, creatinine and uric acid.	Creatinine	29-39	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	0-3
18160964-5	2008	In this group, higher KIM-1 staining predicted a better outcome with improved blood urea nitrogen (BUN), serum creatinine, and estimated glomerular filtration rate (eGFR) over an ensuing 18 months.	Creatinine	111-121	hepatitis A virus cellular receptor 1	Homo sapiens	22-27
18160964-8	2008	KIM-1 expression significantly correlated with serum creatinine and BUN, and inversely with the eGFR on the biopsy day.	Creatinine	53-63	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
17704953-7	2008	Their corresponding creatinine-corrected markers did not vary significantly with urinary flow rate, but the creatinine-corrected excretions of albumin, gamma-GT, and NAG were significantly higher in daytime samples than in overnight samples, with the same (non-significant) trend for A1M.	Creatinine	108-118	inactive glutathione hydrolase 2	Homo sapiens	152-160
19055108-5	2008	Elevated urinary TBARS (micromol/mmol urinary creatinine) in the GP1, GP2 and GC groups were 2.47 (0.37), 3.73 (0.93) and 1.18 (0.24), respectively (GP1 vs. GP2, GP1 vs. GC and GP2 vs. CG, all P &lt; 0.001).	Creatinine	46-56	GTP binding protein 1	Homo sapiens	65-68
18472448-7	2008	Even in these cases, serum NGAL levels decreased rapidly several days after a KTx prior to the recovery of urine output and preceding the decrease in serum creatinine level.	Creatinine	156-166	lipocalin 2	Homo sapiens	27-31
18601606-9	2008	Proteinuria in the urine collected over 24 h was measured with the Exton turbidimetric method by Tomaszewski with modification and expressed in mg/kg body weight/24 h. RESULTS: In the urine of 30 healthy children, FBP-1 activity was in the range from 0-1.74 micromol FPB/h/mmol of creatinine.	Creatinine	281-291	fructose-bisphosphatase 1	Homo sapiens	214-219
18217899-7	2008	RESULTS: Calcineurin inhibitor minimization using mycophenolate mofetil or sirolimus may be associated with a modest increase in creatinine clearance (CrCl) and a decrease in serum creatinine (SCr) in the short term.	Creatinine	129-139	calcineurin binding protein 1	Homo sapiens	9-30
18217899-7	2008	RESULTS: Calcineurin inhibitor minimization using mycophenolate mofetil or sirolimus may be associated with a modest increase in creatinine clearance (CrCl) and a decrease in serum creatinine (SCr) in the short term.	Creatinine	181-191	calcineurin binding protein 1	Homo sapiens	9-30
18421185-5	2008	In multivariable linear regression analysis, GGT activity was independently associated with homocysteine concentration, independent of age, gender, folate, vitamin B12 and serum creatinine levels.	Creatinine	178-188	gamma-glutamyltransferase 1	Homo sapiens	45-48
18791804-8	2008	The log FGF-23 correlated positively with serum creatinine (r = 0.424, P &lt; 0.0001), albumin (r = 0.225, P = 0.0337), Ca (r = 0.392, P = 0.0001), P (r = 0.735, P &lt; 0.0001), and Ca x P product (r = 0.780, P &lt; 0.0001).	Creatinine	48-58	fibroblast growth factor 23	Homo sapiens	8-14
18791804-12	2008	The significant factors associated with FGF-23 in HD patients were age, serum levels of creatinine, albumin, glucose, Ca, P, and Ca x P product.	Creatinine	88-98	fibroblast growth factor 23	Homo sapiens	40-46
18791804-15	2008	In addition, plasma FGF-23 is associated with serum levels of creatinine and albumin.	Creatinine	62-72	fibroblast growth factor 23	Homo sapiens	20-26
18408348-8	2008	Creatinine-adjusted 8-OH-Gua was significantly correlated with age, Ni-U and Cd-B in univariate analysis, while multivariate analysis revealed that Ni-U and Cd-B were significant independent variables and that these two biological exposure indices were positively correlated with 8-OH-Gua.	Creatinine	0-10	DExD-box helicase 21	Homo sapiens	25-28
18408348-8	2008	Creatinine-adjusted 8-OH-Gua was significantly correlated with age, Ni-U and Cd-B in univariate analysis, while multivariate analysis revealed that Ni-U and Cd-B were significant independent variables and that these two biological exposure indices were positively correlated with 8-OH-Gua.	Creatinine	0-10	DExD-box helicase 21	Homo sapiens	285-288
18391570-7	2008	RESULTS: Urinary IL-18 concentration was significantly higher in group I (213.51 +/- 162.15 pg/mg Cr) compared to group II (64.74 +/- 10.95 pg/mg Cr) and to normal controls (37.03 +/- 4.1 pg/mg Cr, p &lt; 0.001).	Creatinine	98-100	interleukin 18	Homo sapiens	17-22
18391570-7	2008	RESULTS: Urinary IL-18 concentration was significantly higher in group I (213.51 +/- 162.15 pg/mg Cr) compared to group II (64.74 +/- 10.95 pg/mg Cr) and to normal controls (37.03 +/- 4.1 pg/mg Cr, p &lt; 0.001).	Creatinine	146-148	interleukin 18	Homo sapiens	17-22
18600028-2	2008	It represents one of the most promising future biomarkers in the diagnostic field of acute kidney injury (AKI), as the increase in NGAL levels is a good predictor of a brief-term onset of AKI, notably anticipating the resulting increase in serum creatinine.	Creatinine	246-256	lipocalin 2	Homo sapiens	131-135
17940058-0	2008	The Cys(311)Ser polymorphism of paraoxonase 2 (PON2) is associated with albumin-to-creatinine ratio (ACR) in Mexican Americans.	Creatinine	83-93	paraoxonase 2	Homo sapiens	32-45
17940058-0	2008	The Cys(311)Ser polymorphism of paraoxonase 2 (PON2) is associated with albumin-to-creatinine ratio (ACR) in Mexican Americans.	Creatinine	83-93	paraoxonase 2	Homo sapiens	47-51
19172802-1	2008	Glomerular filtration rate(GFR) can be estimated from serum (s-) creatinine using the modification of diet in renal disease (MDRD).	Creatinine	65-75	Rap guanine nucleotide exchange factor 5	Homo sapiens	27-30
17965486-8	2007	Multiple stepwise logistic regression analysis demonstrated that high IL-18 level (&gt;or=780 pg/ml) (p&lt;0.0001), together with creatinine level (p=0.024), were independently predictive of 90-day MACO.	Creatinine	130-140	interleukin 18	Homo sapiens	70-75
17166188-1	2007	WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * In burn patients it has been shown ([2]), that there is a correlation between the creatinine clearance (CL(CR)) and the clearance of inulin.	Creatinine	126-136	chymotrypsin C	Homo sapiens	148-154
17166188-2	2007	* The CL(CR) has never been studied in burn patients who have normal serum creatinine.	Creatinine	75-85	chymotrypsin C	Homo sapiens	6-12
17166188-4	2007	WHAT THIS STUDY ADDS: * Despite burn patients having normal serum creatinine concentrations, the study showed that there are large variations in CL(CR) which cannot be detected by single serum creatinine measurements, and which have important implications for drug therapy.	Creatinine	66-76	chymotrypsin C	Homo sapiens	145-151
17166188-4	2007	WHAT THIS STUDY ADDS: * Despite burn patients having normal serum creatinine concentrations, the study showed that there are large variations in CL(CR) which cannot be detected by single serum creatinine measurements, and which have important implications for drug therapy.	Creatinine	193-203	chymotrypsin C	Homo sapiens	145-151
17337355-12	2007	The mean, median and range of UHg was 1.12, 0.55 (&lt;limit of detection (LD)-13.46) microg/g creatinine, respectively.	Creatinine	94-104	small nucleolar RNA host gene 1	Homo sapiens	30-33
17190649-5	2007	Results indicated that serum interleukin (IL)-18 concentrations were significantly higher in PD and low creatinine clearance pre-dialysis CRF (LCC) patients than HD patients (both p &lt; 0.05).	Creatinine	104-114	interleukin 18	Homo sapiens	29-48
17901710-9	2007	In multivariate analysis, only serum creatinine was a predictor of serum NGAL before a PCI.	Creatinine	37-47	lipocalin 2	Homo sapiens	73-77
17901710-11	2007	Serum creatinine level, the presence of diabetes, and the duration of the PCI may affect serum NGAL values and kidney function following a PCI procedure.	Creatinine	6-16	lipocalin 2	Homo sapiens	95-99
16951419-0	2007	Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography.	Creatinine	86-96	lipocalin 2	Homo sapiens	0-42
16951419-0	2007	Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography.	Creatinine	86-96	lipocalin 2	Homo sapiens	44-48
16951419-0	2007	Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography.	Creatinine	136-146	lipocalin 2	Homo sapiens	0-42
16951419-0	2007	Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography.	Creatinine	136-146	lipocalin 2	Homo sapiens	44-48
17072098-0	2006	Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.	Creatinine	78-88	POU class 2 homeobox 2	Homo sapiens	135-140
17072098-5	2006	The apparent IC(50) value for the inhibition of [(14)C]creatinine uptake in hOCT2-HEK293 cells was 1.29+/-0.23 microM for DX-619 and 127+/-27 microM for LVFX, indicating DX-619 to be approximately 100-fold more potent than LVFX at inhibiting the transport of [(14)C]creatinine by hOCT2.	Creatinine	55-65	POU class 2 homeobox 2	Homo sapiens	76-81
17072098-5	2006	The apparent IC(50) value for the inhibition of [(14)C]creatinine uptake in hOCT2-HEK293 cells was 1.29+/-0.23 microM for DX-619 and 127+/-27 microM for LVFX, indicating DX-619 to be approximately 100-fold more potent than LVFX at inhibiting the transport of [(14)C]creatinine by hOCT2.	Creatinine	55-65	POU class 2 homeobox 2	Homo sapiens	280-285
17072098-5	2006	The apparent IC(50) value for the inhibition of [(14)C]creatinine uptake in hOCT2-HEK293 cells was 1.29+/-0.23 microM for DX-619 and 127+/-27 microM for LVFX, indicating DX-619 to be approximately 100-fold more potent than LVFX at inhibiting the transport of [(14)C]creatinine by hOCT2.	Creatinine	266-276	POU class 2 homeobox 2	Homo sapiens	76-81
17072098-6	2006	A Dixon plot revealed that the inhibition by DX-619 of the hOCT2-mediated transport of [(14)C]creatinine was competitive.	Creatinine	93-104	POU class 2 homeobox 2	Homo sapiens	59-64
17072098-7	2006	Fluoroquinolone antibacterials have the ability to inhibit the transport of creatinine by hOCT2, with DX-619 being much more effective than LVFX.	Creatinine	76-86	POU class 2 homeobox 2	Homo sapiens	90-95
16988064-0	2006	Validation of creatinine-based estimates of GFR when evaluating risk factors in longitudinal studies of kidney disease.	Creatinine	14-24	Rap guanine nucleotide exchange factor 5	Homo sapiens	44-47
18416292-4	2006	The aim of this study was to estimate glomerular filtration rate-GFR in patients with normal serum creatinine concentration undergoing primary angioplasty according to body mass index.	Creatinine	99-109	Rap guanine nucleotide exchange factor 5	Homo sapiens	65-68
18416292-13	2006	In patients with normal serum creatinine levels percentage of patients with GFR below 60 ml/min ranges from 4.79% up to 30.74%.	Creatinine	30-40	Rap guanine nucleotide exchange factor 5	Homo sapiens	76-79
16982940-4	2006	GP IIb/IIIa inhibitor dose was defined as excessive if not reduced when creatinine clearance was &lt; 50 mL/min for eptifibatide or &lt; 30 mL/min for tirofiban.	Creatinine	72-82	integrin subunit alpha 2b	Homo sapiens	0-6
16978023-7	2006	The mean concentration of AFB(1)-N(7)-Gua, measured in 16/20 urine samples with levels above the method"s limit of quantitation, was 2.9 pg/20 mL urine (0.28 pg/mg creatinine) with a range of &lt;0.8-7.2 pg/20 mL urine (0.04-65 pg/mg creatinine).	Creatinine	234-244	DExD-box helicase 21	Homo sapiens	38-41
16908121-5	2006	Statistical analysis demonstrated a relationship between C(max) and the area of the burn and Unit Burn Standard, and between AMK clearance and creatinine clearance (Cl(CR)).	Creatinine	143-153	chymotrypsin C	Homo sapiens	165-171
16704755-11	2006	Patients with the MTHFR TT genotype had higher plasma tHcy, serum creatinine, cholesterol and triglyceride concentrations than patients with the MTHFR CC genotype.	Creatinine	66-76	methylenetetrahydrofolate reductase	Homo sapiens	18-23
16313894-6	2006	In addition, serum creatinine concentrations correlated with MMP-2 activity (R=0.288, p&lt;0.05) and inversely correlated with that of MMP-9 (R=0.344, p&lt;0.01).	Creatinine	19-29	matrix metallopeptidase 9	Homo sapiens	135-140
16313894-7	2006	CONCLUSIONS: This study demonstrated a correlation between MMP-2, -9 and serum creatinine in CKD patients to suggest that MMP-2 and MMP-9 might contribute in the pathogenesis of CKD.	Creatinine	79-89	matrix metallopeptidase 9	Homo sapiens	132-137
16691036-5	2006	RESULTS: Plasma FGF-23 correlated with creatinine clearance (r2 = -0.584, p &lt; 0.0001) and plasma phosphorus (r2 = 0.347, p &lt; 0.001) in CKD patients and with plasma phosphorus (r2 = 0.448, p &lt; 0.001) in end-stage renal disease patients.	Creatinine	39-49	fibroblast growth factor 23	Homo sapiens	16-22
16691036-10	2006	CONCLUSIONS: In CKD, FGF-23 levels rose with decreasing creatinine clearance rates and increasing plasma phosphorus levels, and rapidly decreased post-transplantation suggesting FGF-23 is cleared by the kidney.	Creatinine	56-66	fibroblast growth factor 23	Homo sapiens	21-27
16271208-9	2005	HO-1 transduced autografts had less renal ischemic injury and lower serum creatinine level compared with control animals (P &lt; 0.05).	Creatinine	74-84	heme oxygenase 1	Rattus norvegicus	0-4
16007563-16	2005	FFM and BCM estimated with mf BIA had a closer correlation with creatinine index than sf BIA.	Creatinine	64-74	TNF receptor superfamily member 17	Homo sapiens	8-11
15919303-7	2005	RESULTS: Creatinine clearance (preoperative, 74 +/- 25 vs 78 +/- 29 mL/min; day 1, 74 +/- 26 vs 76 +/- 31 mL/min; day 4, 70 +/- 26 vs 72 +/- 29 mL/min) and creatinine levels (preoperative, 99 +/- 25 vs 95 +/- 27 micromol/L; day 1, 101 +/- 29 vs 104 +/- 35 micromol/L; day 4, 110 +/- 44 vs 113 +/- 60 micromol/L), as well as postoperative complications (stroke 1% vs 1%; hemofiltration 1.5% vs 3.7%; death 1.2% vs 2.3%), were overall similar between OPCAB and on-CAB patients.	Creatinine	9-19	neural proliferation, differentiation and control 1	Homo sapiens	451-454
15919303-8	2005	Patients with preoperative CrCl less than 50 mL/min had higher creatinine levels in the on-CAB group on day 1 (p = 0.026), although CrCl was similar between groups.	Creatinine	63-73	neural proliferation, differentiation and control 1	Homo sapiens	91-94
15716336-3	2005	Several prediction formulas that are based on serum creatinine are currently used to estimate the GFR, but none has been validated in a large cohort of individuals with diabetes.	Creatinine	52-62	Rap guanine nucleotide exchange factor 5	Homo sapiens	98-101
15716336-10	2005	Refitting the MDRD formula to the DCCT data gave a more accurate and unbiased prediction of GFR from serum creatinine; percentage of estimate within 10% of measured GFR increased to 56%.	Creatinine	107-117	Rap guanine nucleotide exchange factor 5	Homo sapiens	92-95
15744000-7	2005	Urinary hKIM-1 was normalized to the urinary creatinine concentration (U(Cr)).	Creatinine	45-55	hepatitis A virus cellular receptor 1	Homo sapiens	8-14
15677863-4	2005	The IL-18 concentration negatively correlated with creatinine clearance (Ccr).	Creatinine	51-61	interleukin 18	Homo sapiens	4-9
16130407-8	2005	IP-10 levels became higher with the progression of nephropathy : IP-10 levels were 148.9+/-14.5, 174.2+/-17.2 and 231.9+/-31.3 pg/m/ in patients with an urinary albumin creatinine ratio of &lt;30, 30 to 300 and &gt;300 microg/mg Cr, respectively.	Creatinine	169-179	C-X-C motif chemokine ligand 10	Homo sapiens	0-5
15609953-7	2004	In a search for reactivity, reactions of 10(+) with some nucleophiles, hydride and diethylamine, were carried out to give mixtures of C11- and C13-adducts.	Creatinine	71-78	RNA polymerase III subunit K	Homo sapiens	134-137
15609953-7	2004	In a search for reactivity, reactions of 10(+) with some nucleophiles, hydride and diethylamine, were carried out to give mixtures of C11- and C13-adducts.	Creatinine	71-78	homeobox C13	Homo sapiens	143-146
15327389-5	2004	RESULTS: The 16 individuals carrying the deletion mutation excreted 5.8 +/- 6.3 mg THP/g creatinine into their urine.	Creatinine	89-99	uromodulin	Homo sapiens	83-86
15327389-6	2004	The 18 unaffected relatives from the same family excreted 40.8 +/- 9.7 mg THP/g creatinine (P < 0.0001) and the four spouses excreted 43.9 +/- 25.1 mg THP/g creatinine (P < 0.0001 vs. individuals with the deletion mutation).	Creatinine	80-90	uromodulin	Homo sapiens	74-77
15327389-7	2004	THP excretion of seven individuals with other UMOD gene mutations was also extremely low (range of 0.14 to 5.9 mg THP/g creatinine).	Creatinine	120-130	uromodulin	Homo sapiens	0-3
15253718-7	2004	Tissue factor inhibition in defibrinogenated rabbits resulted in further protection of renal function (creatinine 140 +/- 19 micromol/L, P &lt; 0.01) and reduced proteinuria (0.4 +/- 0.2g/day, untreated 2.6 +/- 0.4 g/day, P &lt;0.01), which was significantly increased by defibrinogenation alone (ancrod-treated, 5.6 +/- 1.2 g/day).	Creatinine	103-113	tissue factor	Oryctolagus cuniculus	0-13
15028668-4	2004	GAMT knockout mice have markedly increased guanidinoacetate (GAA) and reduced creatine and creatinine levels in brain, serum and urine, which are key findings in human GAMT patients.	Creatinine	91-101	guanidinoacetate methyltransferase	Mus musculus	0-4
14527840-5	2003	After adjustment, participants with the ALAD(2) allele had lower mean serum creatinine and higher calculated creatinine clearance.	Creatinine	76-86	aminolevulinate dehydratase	Homo sapiens	40-44
14527840-5	2003	After adjustment, participants with the ALAD(2) allele had lower mean serum creatinine and higher calculated creatinine clearance.	Creatinine	109-119	aminolevulinate dehydratase	Homo sapiens	40-44
14527840-7	2003	Among those with the ALAD(1-2) genotype, higher lead measures were associated with lower BUN and serum creatinine and higher calculated creatinine clearance.	Creatinine	103-113	aminolevulinate dehydratase	Homo sapiens	21-25
14527840-7	2003	Among those with the ALAD(1-2) genotype, higher lead measures were associated with lower BUN and serum creatinine and higher calculated creatinine clearance.	Creatinine	136-146	aminolevulinate dehydratase	Homo sapiens	21-25
14620929-7	2003	Renal dysfunction characterized by decreased creatinine clearance (C(cr)) was more severe in AM +/- after Ang II infusion.	Creatinine	45-55	adrenomedullin	Mus musculus	93-95
12716753-5	2003	Over a mean follow-up interval of 3.9 +/- 1.8 years, serum creatinine concentration doubled in 19 patients on CR-LIPE (21%) and in 31 control subjects (39%) (P &lt; 0.01).	Creatinine	59-69	lipase E, hormone sensitive type	Homo sapiens	113-117
12738401-3	2003	The results were compared with creatinine clearance (Ccr), which was measured (mCcr) and estimated (eCcr) with the Cockroft-Gault formula, and correlated with 24-h urine protein and early morning urine albumin/creatinine excretion ratio.	Creatinine	31-41	LETM1 domain containing 1	Mus musculus	53-56
12759891-4	2003	In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (&lt;30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to &gt;300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; &gt;&gt;300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL).	Creatinine	186-196	interleukin 18	Homo sapiens	13-18
12759891-4	2003	In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (&lt;30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to &gt;300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; &gt;&gt;300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL).	Creatinine	245-255	interleukin 18	Homo sapiens	13-18
12759891-4	2003	In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (&lt;30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to &gt;300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; &gt;&gt;300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL).	Creatinine	245-255	interleukin 18	Homo sapiens	13-18
12686661-10	2003	Creatinine clearance was also a determinant of the inflammatory activity score (beta=-0.31, P=0.025) and sPLA(2) (beta=-0.32, P=0.024), although this was no longer significant after correction for systolic blood pressure.	Creatinine	0-10	phospholipase A2 group IIA	Homo sapiens	105-112
12717852-10	2003	Similar results were also obtained between pulmonary TNF-alpha mRNA expression and myeloperoxidase activities (P&lt;0.01), whereas there was a highly negative correlation between levels of renal TNFR-I mRNA expression and serum creatinine.	Creatinine	228-238	TNF receptor superfamily member 1A	Rattus norvegicus	195-201
12390326-5	2002	Elevation of plasma IL-18 in RSLE correlated positively and significantly with SLE -disease activity index and plasma NO concentration (r = 0.623, P &lt; 0.0001 and r = 0.455, P = 0.017, respectively), and the latter also showed a positive and significant correlation with plasma creatinine (r = 0.410, P = 0.034) and urea (r = 0.685, P &lt; 0.0001).	Creatinine	280-290	interleukin 18	Homo sapiens	20-25
12127325-6	2002	The urinary concentrations of 4-hydroxybutyric acid and of 3,4-dihydroxybutyric acid from the patient with an SSADH deficiency were 880-3628 mmol mol(-1) creatinine (control; 3.3+/-3.3 mmol mol(-1) creatinine) and 810-1366 mmol mol(-1) creatinine (control; 67.4+/-56.2 mmol mol(-1) creatinine), respectively.	Creatinine	154-164	aldehyde dehydrogenase 5 family member A1	Homo sapiens	110-115
12127325-6	2002	The urinary concentrations of 4-hydroxybutyric acid and of 3,4-dihydroxybutyric acid from the patient with an SSADH deficiency were 880-3628 mmol mol(-1) creatinine (control; 3.3+/-3.3 mmol mol(-1) creatinine) and 810-1366 mmol mol(-1) creatinine (control; 67.4+/-56.2 mmol mol(-1) creatinine), respectively.	Creatinine	198-208	aldehyde dehydrogenase 5 family member A1	Homo sapiens	110-115
12127325-6	2002	The urinary concentrations of 4-hydroxybutyric acid and of 3,4-dihydroxybutyric acid from the patient with an SSADH deficiency were 880-3628 mmol mol(-1) creatinine (control; 3.3+/-3.3 mmol mol(-1) creatinine) and 810-1366 mmol mol(-1) creatinine (control; 67.4+/-56.2 mmol mol(-1) creatinine), respectively.	Creatinine	198-208	aldehyde dehydrogenase 5 family member A1	Homo sapiens	110-115
12127325-6	2002	The urinary concentrations of 4-hydroxybutyric acid and of 3,4-dihydroxybutyric acid from the patient with an SSADH deficiency were 880-3628 mmol mol(-1) creatinine (control; 3.3+/-3.3 mmol mol(-1) creatinine) and 810-1366 mmol mol(-1) creatinine (control; 67.4+/-56.2 mmol mol(-1) creatinine), respectively.	Creatinine	198-208	aldehyde dehydrogenase 5 family member A1	Homo sapiens	110-115
12173815-11	2002	From equal preoperative values, a significantly higher release of urinary RBP:Cr (7,807 +/- 2,227 vs 3,942 +/- 2,528; p &lt; 0.001) and urinary microalbumin:Cr (59.4 +/- 38.0 vs 4.7 +/- 6.7; p &lt; 0.0001) occurred in group A, peaking on day 1 before returning to approximate baseline levels.	Creatinine	78-80	retinol binding protein 4	Homo sapiens	74-77
12376270-5	2002	RESULTS: Plasma creatinine measured 24 h after the injection of glycerol was 412.31+/-94.42 micromol/L in rats treated with anti-ICAM-1, significantly lower than that in CD3 mAb-treated rats (990.21 +/-171.25 micromol/L, P&lt;0.05).	Creatinine	16-26	intercellular adhesion molecule 1	Rattus norvegicus	129-135
12103384-5	2002	Glomerular and tubular injury were measured respectively by urinary excretion of microalbumin and retinol binding protein (RBP) indexed to creatinine (Cr).	Creatinine	139-149	retinol binding protein 4	Homo sapiens	98-121
12103384-5	2002	Glomerular and tubular injury were measured respectively by urinary excretion of microalbumin and retinol binding protein (RBP) indexed to creatinine (Cr).	Creatinine	139-149	retinol binding protein 4	Homo sapiens	123-126
12103384-11	2002	A significant and similar rise in urinary RBP:Cr occurred in both groups peaking on day 1 (3183+/-2534 vs. 4035+/-4079; P=0.43) before reapproximating baseline levels.	Creatinine	46-48	retinol binding protein 4	Homo sapiens	42-45
12052845-6	2002	Chronic adrenomedullin treatment significantly improved renal function (serum creatinine -87%, creatinine clearance +114%, urinary protein excretion -59%) and histological findings (glomerular injury score -54%) without changing mean arterial pressure compared with untreated Dahl salt-sensitive rats.	Creatinine	78-88	adrenomedullin	Rattus norvegicus	8-22
12052845-6	2002	Chronic adrenomedullin treatment significantly improved renal function (serum creatinine -87%, creatinine clearance +114%, urinary protein excretion -59%) and histological findings (glomerular injury score -54%) without changing mean arterial pressure compared with untreated Dahl salt-sensitive rats.	Creatinine	95-105	adrenomedullin	Rattus norvegicus	8-22
12110092-6	2002	RESULTS: Urinary excretion of AM (pmol per mg urinary creatinine) in patients with Behcet"s syndrome (81.3 +/- 35.1) was significantly higher (P &lt; 0.001) than in control subjects (31.2 +/- 16.1).	Creatinine	54-64	adrenomedullin	Homo sapiens	30-32
12020626-9	2002	Baseline ICAM-1 was significantly higher in the patients who developed macrovascular disease than in those who did not, and it remained so even after adjusting for age, systolic blood pressure, creatinine and glycaemic control (P=0.0007).	Creatinine	194-204	intercellular adhesion molecule 1	Homo sapiens	9-15
12063990-8	2002	Additionally, the creatinine clearances were increased and statistically significant with somatostatin.	Creatinine	18-28	somatostatin	Homo sapiens	90-102
11835642-4	2002	Patients with elevated cTnI were older and had a higher incidence of postinfarction angina and lower creatinine clearance compared to patients who did not have cTnI elevation.	Creatinine	101-111	troponin I3, cardiac type	Homo sapiens	23-27
11892904-4	2002	Results showed that urinary excretion of RBP (average from first week values) was 1.06+/-0.67 g/mol creatinine (mean +/- SD) in controls, 1.99+/-1.41 in antibiotic-treated newborns, 3.99+/-4.57 in anoxic newborns and 3.75+/-3.48 in anoxic newborns under antibiotic treatment.	Creatinine	100-110	retinol binding protein 4	Homo sapiens	41-44
12608627-7	2002	There was also correlation between Cd-U (microg/g creatinine), measured in 1998-1999, and RBP-U or beta2M-S (r = 0.343 and 0.198).	Creatinine	50-60	retinol binding protein 4	Homo sapiens	90-93
12608627-9	2002	According to the dose-response relationship, an increase in RBP excretion above 300 microg/g creatinine can be expected in 10% of subjects at the integrated exposure index (Cd-B x t) of about 450 microg/l x years, and an increase in beta2M-S above the accepted cut-off point of 2.4 mg/l can be expected in 10 % of subjects at Cd-B x t of about 190 microg/l x years.	Creatinine	93-103	retinol binding protein 4	Homo sapiens	60-63
11721159-12	2001	The glomerular and interstitial CD44 and hyaluronic acid expression correlated with proteinuria, and interstitial CD44 and hyaluronic acid expression correlated with creatinine clearance rate.	Creatinine	166-176	CD44 molecule (Indian blood group)	Homo sapiens	114-118
11562415-6	2001	For each 5 L/wk per 1.73 m(2) increment in GFR, there was a 12% decrease in the relative risk (RR) of death (RR, 0.88; 95% confidence interval [CI], 0.83 to 0.94) but no association with peritoneal creatinine clearance (RR, 1.00; 95% CI, 0.90 to 1.10).	Creatinine	198-208	Rap guanine nucleotide exchange factor 5	Homo sapiens	43-46
11571133-6	2001	ICAM-1 positive interstitial leucocytes were 234 (307)/mm2; this expression correlated with glomerulosclerosis, tubular atrophy, interstitial fibrosis and serum creatinine (Cr) level.	Creatinine	161-171	intercellular adhesion molecule 1	Homo sapiens	0-6
21181357-8	2010	With higher cystatin C quintiles (&gt;=1.00 mg/L and &gt;=1.17 mg/L), the hazard ratios for CHD were 2.16 (1.23-3.81) and 2.34 (1.25-4.38), similar to those of creatinine 2.21 (1.21-4.03) and 2.03 (1.07-3.84).	Creatinine	160-170	cystatin C	Homo sapiens	12-22
20847143-3	2010	Here, treating wild-type mice with neutralizing anti-HMGB1 antibody protected them against kidney IRI, evidenced by lower serum creatinine and less tubular damage than untreated mice.	Creatinine	128-138	high mobility group box 1	Mus musculus	53-58
21102379-9	2010	Creatinine at 1 day showed a positive correlation with urinary HGF levels at 1 day and at 3 months (R = 0.54, P &lt;0.05 and R = 0.82, P &lt;0.01, respectively).	Creatinine	0-10	hepatocyte growth factor	Homo sapiens	63-66
21102379-10	2010	Creatinine at 7 days positively correlated with HGF levels at 6 months (R = 0.82, P &lt;0.05).	Creatinine	0-10	hepatocyte growth factor	Homo sapiens	48-51
20702592-5	2010	The TIM2(-/-) mice showed approximately fivefold higher injury as estimated by blood urea nitrogen and serum creatinine at 48 h that was confirmed by significantly increased proximal tubular damage assessed histologically (H &amp; E staining).	Creatinine	109-119	T cell immunoglobulin and mucin domain containing 2	Mus musculus	4-8
20579953-7	2010	RESULTS: In the RCAS1 siRNA group, blood pressure significantly raised on postcoital days 9.5, 10.5, 11.5, and 15.5, whereas urine albumin/creatinine ratio was significantly increased on postcoital day 9.5 CONCLUSION: Our results suggest the importance of RCAS1 protein in the pathophysiologic condition of preeclampsia.	Creatinine	139-149	estrogen receptor-binding fragment-associated gene 9	Mus musculus	16-21
21206678-7	2010	Using Cox proportional hazard model, the age and gender of the donors along with the creatinine level of the patients at discharge were shown to have a significant influence on survival.	Creatinine	85-95	cytochrome c oxidase subunit 8A	Homo sapiens	6-9
20409603-5	2010	Plasma visfatin levels were positively correlated with systolic blood pressure, body weight, fasting blood glucose, plasma levels of MCP-1, urinary albumin excretion (UAE), and carotid intima-media thickness (IMT), and were inversely correlated with plasma adiponectin, and creatinine clearance.	Creatinine	274-284	nicotinamide phosphoribosyltransferase	Homo sapiens	7-15
20525986-3	2010	Galectin-3 levels were associated with older age (r = 0.26, P = 0.006), lower creatinine clearance (r = -0.42, P &lt; 0.001), and higher levels of N-terminal-proBNP (r = 0.39, P &lt; 0.001).	Creatinine	78-88	galectin 3	Homo sapiens	0-10
20484555-8	2010	The renal clearance of cephalexin in Mate1(-/-) mice was approximately 60% of that in Mate1(+/+) mice and seemed to be near the creatinine clearance.	Creatinine	128-138	solute carrier family 47, member 1	Mus musculus	37-42
20485332-4	2010	A significant increase in urinary CD80, normalized to urinary creatinine, was found in patients with MCD in relapse compared to those in remission or those with FSGS.	Creatinine	62-72	CD80 molecule	Homo sapiens	34-38
20979791-6	2010	The expression of CD80 and CD86 in renal tissue correlated with the systemic lupus erythematosus (SLE) disease activity index score, the degree of proteinuria, creatinine clearance and anti-dsDNA antibody.	Creatinine	160-170	CD80 molecule	Homo sapiens	18-22
20979791-6	2010	The expression of CD80 and CD86 in renal tissue correlated with the systemic lupus erythematosus (SLE) disease activity index score, the degree of proteinuria, creatinine clearance and anti-dsDNA antibody.	Creatinine	160-170	CD86 molecule	Homo sapiens	27-31
20530261-3	2010	Compared with wild type animals, mMCP-4-deficient mice exhibited lower proteinuria, blood creatinine, and blood urea nitrogen levels, indicating an aggravating role of mMCP-4.	Creatinine	90-100	mast cell protease 4	Mus musculus	33-39
20628107-0	2010	A simple method to evaluate residual renal function by spot urinary cystatin C-to-creatinine ratio in peritoneal dialysis patients.	Creatinine	82-92	cystatin C	Homo sapiens	68-78
20458271-6	2010	In a mouse model of renal IRI, a deficiency in TGF-beta1 expression increased the severity of renal injury, as indicated by more severe renal tubular damage, higher levels of serum creatinine or blood urea nitrogen in TGF-beta1 deficient mice as compared with those in wild-type controls.	Creatinine	181-191	transforming growth factor, beta 1	Mus musculus	47-56
20140438-4	2010	RESULTS: Baseline NT-pro-BNP was associated with baseline creatinine, left-ventricular mass index and NYHA class and predicted regression of LV-mass after 2 months.	Creatinine	58-68	natriuretic peptide B	Homo sapiens	25-28
20084405-7	2010	The median urine IL-6/creatinine was significantly higher in patients with VUR than in those without VUR (5.72 vs. 3.73).	Creatinine	22-32	VUR	Homo sapiens	75-78
20084405-8	2010	In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p&lt;0.05, R=0.305).	Creatinine	87-97	VUR	Homo sapiens	17-20
20534254-3	2010	The Cox proportional hazard regression model was used to analyze donor age and serum creatinine concentration before procurement, recipient age, cold ischemia time, delayed graft function, number of renal arteries, and presence of a double-J stent.	Creatinine	85-95	cytochrome c oxidase subunit 8A	Homo sapiens	4-7
19937361-9	2010	Creatinine clearance was higher in N-IgAN than IgAN patients (89.4 vs. 74.4 ml/min; P &lt; 0.001).	Creatinine	0-10	IGAN1	Homo sapiens	37-41
19765773-8	2010	Albumin-creatinine ratio, fibrinogen, uric acid, homocysteine, high-sensitivity C-reactive protein, and lipoprotein(a) all showed significant correlations with cystatin C that were generally higher than those with eGFR.	Creatinine	8-18	cystatin C	Homo sapiens	160-170
19765773-9	2010	Cystatin C level was independently associated with HOMA-IR (beta = 0.0380, P = .0082), albumin-creatinine ratio (beta = 0.0004, P &lt; .0001), uric acid (beta = 0.0666, P &lt; .0001), and homocysteine (beta = 0.0087, P = .0004).	Creatinine	95-105	cystatin C	Homo sapiens	0-10
19635565-6	2010	In multiple regression analyses, creatinine, body mass index, triglycerides, AGEs and insulin were independently correlated with serum PEDF levels.	Creatinine	33-43	serpin family F member 1	Homo sapiens	135-139
20091551-12	2010	Serum creatinine was significantly lower for IL2Ra treated patients at six months (4 studies: MD -11.20 micromol/L 95% CI -19.94 to -2.09).	Creatinine	6-16	interleukin 2 receptor subunit alpha	Homo sapiens	45-50
19828677-9	2010	Renal recovery was facilitated by DLL4 treatment, as evidenced by faster return of serum creatinine to baseline by 48 h in DLL4-treated rats as against 5 days in vehicle-treated control rats.	Creatinine	89-99	delta like canonical Notch ligand 4	Rattus norvegicus	34-38
19828677-9	2010	Renal recovery was facilitated by DLL4 treatment, as evidenced by faster return of serum creatinine to baseline by 48 h in DLL4-treated rats as against 5 days in vehicle-treated control rats.	Creatinine	89-99	delta like canonical Notch ligand 4	Rattus norvegicus	123-127
20690093-11	2010	Cystatin C concentration also correlated well with the atherosclerotic biochemical risk factors like homocysteine, creatinine and hs-CRP.	Creatinine	115-125	cystatin C	Homo sapiens	0-10
20052346-6	2010	With 24-hr urine creatinine clearance (Ccr) as the reference for GFR, 1/cystatin C (r=0.702, P&lt;0.001) showed a significantly higher correlation with Ccr than 1/creatinine (r=0.665, P&lt;0.001).	Creatinine	17-27	cystatin C	Homo sapiens	72-82
20052346-6	2010	With 24-hr urine creatinine clearance (Ccr) as the reference for GFR, 1/cystatin C (r=0.702, P&lt;0.001) showed a significantly higher correlation with Ccr than 1/creatinine (r=0.665, P&lt;0.001).	Creatinine	163-173	cystatin C	Homo sapiens	72-82
20052346-8	2010	The area under the curve (AUC) at ROC plots identified that of serum cystatin C was significantly greater than that of serum creatinine (AUC 0.804 of cystatin C and AUC 0.745 of creatinine).	Creatinine	178-188	cystatin C	Homo sapiens	69-79
19786933-5	2010	Postoperative serum creatinine and urea nitrogen levels were significantly higher in patients with eGFR3 and eGFR5 abnormal levels than in patients with eGFR3 and eGFR5 normal levels.	Creatinine	20-30	C-type lectin domain containing 14A	Homo sapiens	109-114
19592389-15	2009	CONCLUSION: The DSC index, derived from a standard CMR scan and plasma creatinine before implantation, is a powerful predictor of cardiovascular mortality after CRT.	Creatinine	71-81	desmocollin 3	Homo sapiens	16-19
19762497-7	2009	An equation using both creatinine and cystatin C (in addition to age, race, and gender) resulted in weaker associations than equations using only cystatin C (with or without age, race, and gender).	Creatinine	23-33	cystatin C	Homo sapiens	146-156
19648301-14	2009	Medium or high levels of OPG were predictive of a urine protein/creatinine ratio of &gt; or = 0.5.	Creatinine	64-74	TNF receptor superfamily member 11b	Homo sapiens	25-28
19699346-9	2009	The covariates age, history of atrial fibrillation, creatinine, and body mass index affected BNP levels independently of HF.	Creatinine	52-62	natriuretic peptide B	Homo sapiens	93-96
19699346-10	2009	The subgroup-specific BNP cutoff that maintained 91% sensitivity was 184 pg/ml for patients &gt; or =75 years, 150 pg/ml for those with atrial fibrillation, and 449 pg/ml for patients with a creatinine &gt; or =2 mg/dl.	Creatinine	191-201	natriuretic peptide B	Homo sapiens	22-25
19769007-8	2009	hK1 amidase activity is expressed in microM/(min x mg creatinine) to correct for differences in urine flow rate.	Creatinine	54-64	keratin 1	Homo sapiens	0-3
19769007-10	2009	RESULTS: Human tissue kallikrein amidase activity was significantly lower in the urine of hypertensive patients (0.210 microM/(min x mg creatinine) than in the urine of control subjects (0.260 microM/(min x mg creatinine) (P = .010).	Creatinine	136-146	kallikrein 1	Homo sapiens	15-32
19769007-10	2009	RESULTS: Human tissue kallikrein amidase activity was significantly lower in the urine of hypertensive patients (0.210 microM/(min x mg creatinine) than in the urine of control subjects (0.260 microM/(min x mg creatinine) (P = .010).	Creatinine	210-220	kallikrein 1	Homo sapiens	15-32
19361605-6	2009	BNP correlated independently with time after HT (p &lt;0.001), pulmonary artery systolic pressure (p &lt;0.001), creatinine (p = 0.001), and age (p = 0.0012).	Creatinine	113-123	natriuretic peptide B	Homo sapiens	0-3
19436134-9	2009	Mutant FGF23 significantly decreased serum creatinine and serum urea nitrogen.	Creatinine	43-53	fibroblast growth factor 23	Rattus norvegicus	7-12
19152009-9	2009	Among the patients, the CC16/creatinine ratio was correlated with both the beta2-microglobulin/creatinina ratio (r = 0.76, P &lt; 0.001) and the NAG/creatinine ratio (r = 0.6, P &lt; 0.001).	Creatinine	29-39	O-GlcNAcase	Homo sapiens	145-148
19252175-6	2009	RESULTS: In newly diagnosed patients, cystatin-C was elevated and showed strong correlations with advanced ISS stage, extensive bone disease, high beta(2)-microglobulin, high serum creatinine, and low creatinine clearance.	Creatinine	181-191	cystatin C	Homo sapiens	38-48
19252175-6	2009	RESULTS: In newly diagnosed patients, cystatin-C was elevated and showed strong correlations with advanced ISS stage, extensive bone disease, high beta(2)-microglobulin, high serum creatinine, and low creatinine clearance.	Creatinine	201-211	cystatin C	Homo sapiens	38-48
19158357-5	2009	The mass transfer coefficient for creatinine correlated with MC phenotype and with COX-2 levels.	Creatinine	34-44	prostaglandin-endoperoxide synthase 2	Mus musculus	83-88
18796544-6	2008	The upregulated expressions of UII and GPR14 in the kidney were accompanied by significant increases in the renal profibrotic factor transforming growth factor (TGF)-beta1 expression, the renal extracellular matrix (fibronectin and collagen IV) accumulation, and the renal dysfunction (increases in urinal N-acetyl-beta-d-glucosaminidase content, 24-h urinary retinol-binding protein excretion rate, and decrease in creatinine clearance rate).	Creatinine	416-426	urotensin 2 receptor	Rattus norvegicus	39-44
18987758-6	2008	With regard to long-term outcome (mean follow-up 649 days), multivariate Cox regression models found elevated creatinine levels at 30 days (hazard rate ratio [HRR] 5.48, 95% CI 2.85 to 10.53), but not CIN within 72 h (HRR 1.12, 95% CI 0.63 to 2.02), to be associated with increased mortality.	Creatinine	110-120	nuclear receptor subfamily 1 group H member 4	Homo sapiens	218-223
18644360-9	2008	RESULTS: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio (r=0.29, p&lt;0.0001) and negatively associated with estimated GFR (r=-0.24, p=0.0001).	Creatinine	83-93	amine oxidase copper containing 3	Homo sapiens	15-20
18824903-8	2008	In the proportional hazards regression model adjusted for age, male gender, and creatinine concentration, measured at days 0, 3, 5, and 12, BNP concentration at day 5 showed an increased hazard for reaching the end point (hazard ratio: 1.407; 95% confidence interval: 1.033-1.916; p = 0.030).	Creatinine	80-90	natriuretic peptide B	Homo sapiens	140-143
18536938-9	2008	A significant correlation was found between CysC and Cr on day 1 (r = 0.21, p = 0.031), but no correlation was found according to day 3 blood samples (r = 0.19, p = 0.053).	Creatinine	53-55	cystatin C	Homo sapiens	44-48
18715664-3	2008	In diabetes, PEDF correlated with BMI, serum creatinine and LDL-cholesterol, but not with other lipids, HbA1c or CRP.	Creatinine	45-55	serpin family F member 1	Homo sapiens	13-17
18752646-6	2008	The inhibitory effects of inhibitors and antisense oligonucleotides on CTN uptake by isolated choroid plexus indicated the involvement of rat organic cation transporter 3 (rOCT3) and creatine transporter (CRT) in CTN transport.	Creatinine	71-74	solute carrier family 22 member 3	Rattus norvegicus	142-170
18752646-6	2008	The inhibitory effects of inhibitors and antisense oligonucleotides on CTN uptake by isolated choroid plexus indicated the involvement of rat organic cation transporter 3 (rOCT3) and creatine transporter (CRT) in CTN transport.	Creatinine	213-216	solute carrier family 22 member 3	Rattus norvegicus	142-170
18692125-5	2008	Increase of aspartate transanimase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine in the serum of CTX-treated mice was significantly reversed by ATF.	Creatinine	95-105	glial cell line derived neurotrophic factor	Mus musculus	169-172
18788856-3	2008	OBJECTIVE: To evaluate the potential relationships among the biochemical markers creatinine, estimated glomerular filtration rate, and cystatin C and their association with Lp(a) in patients with impaired renal function.	Creatinine	81-91	lipoprotein(a)	Homo sapiens	173-178
18034779-7	2008	Furthermore, visfatin concentrations correlated positively with age, blood pressure, creatinine, free fatty acids (FFA), IL-6 and C reactive protein (CRP), whereas a negative correlation was found with fasting insulin and the HOMA-insulin resistance index (HOMA-IR).	Creatinine	85-95	nicotinamide phosphoribosyltransferase	Homo sapiens	13-21
18452409-1	2008	OBJECTIVE: Recent studies have shown that serum cystatin C is a better marker for measuring the glomerular filtration rate (GFR) than the conventional method, using serum creatinine concentration.	Creatinine	171-181	cystatin C	Homo sapiens	48-58
18452409-5	2008	RESULT: The mean GFR (+/-SD) of 95 patients predicted by serum cystatin C concentration (64.6 +/- 30.6 mL/min) was significantly lower (P &lt; 0.001) than predicted by serum creatinine concentration (77.4 +/- 43.9 mL/min).	Creatinine	174-184	cystatin C	Homo sapiens	63-73
18523656-9	2008	The plasma PEDF levels were significantly correlated with the levels of BUN and creatinine (r=0.54, p&lt;0.0001; r=0.57, p&lt;0.0001, respectively).	Creatinine	80-90	serpin family F member 1	Homo sapiens	11-15
17986474-10	2008	Urinary A1M adjusted for creatinine concentration correlated well with the 24 h excretion.	Creatinine	25-35	alpha-1-microglobulin/bikunin precursor	Homo sapiens	8-11
17986474-14	2008	Moreover, in spot samples (e.g. first morning samples) adjustment of A1M for creatinine or specific gravity is a reliable alternative to 24 h urine.	Creatinine	77-87	alpha-1-microglobulin/bikunin precursor	Homo sapiens	69-72
18635422-7	2008	In the healthy volunteers visfatin correlated significantly with ICAM (r=-0.37, p&lt;0.05) and serum creatinine (0.38, p&lt;0.05).	Creatinine	101-111	nicotinamide phosphoribosyltransferase	Homo sapiens	26-34
19189537-13	2008	The highest activity of NAG-B was observed in urine of smoking founders (11.35 +/- 7.85 U/g creatinine), then non-smoking founders (9.7 +/- 8.75 U/ g creatinine).	Creatinine	92-102	O-GlcNAcase	Homo sapiens	24-27
19189537-13	2008	The highest activity of NAG-B was observed in urine of smoking founders (11.35 +/- 7.85 U/g creatinine), then non-smoking founders (9.7 +/- 8.75 U/ g creatinine).	Creatinine	150-160	O-GlcNAcase	Homo sapiens	24-27
17822797-3	2007	Correlation coefficients between CysC-GFR and each of the creatinine-based GFR measurements (MDRD-GFR, Cockcroft-Gault-GFR, and CLcr) were 0.589, 0.569, and 0.479 (p&lt;0.001).	Creatinine	58-68	cystatin C	Homo sapiens	33-37
18089325-7	2007	There were significant positive correlations between serum PAPP-A levels and urea (r=.547, P=.001), creatinine (r=.497, P=.001), uric acid (r=.452, P=.001), and CRP values (r=.387, P=.001).	Creatinine	100-110	pappalysin 1	Homo sapiens	59-65
18089325-9	2007	CONCLUSION: We concluded that PAPP-A level was elevated in renal transplant patients and that high levels of PAPP-A might be a prognostic marker owing to their close association with high serum levels of urea, creatinine, uric acid, and CRP.	Creatinine	210-220	pappalysin 1	Homo sapiens	109-115
17289743-9	2007	Moreover, in patients with normal plasma creatinine, elevated cystatin C was associated with significantly higher mortality at 12 months: 40.4% vs. 12.6% in patients with both markers within normal range, P &lt; 0.0001.	Creatinine	41-51	cystatin C	Homo sapiens	62-72
17289743-11	2007	Furthermore, cystatin C identifies patients with poor prognosis despite normal plasma creatinine.	Creatinine	86-96	cystatin C	Homo sapiens	13-23
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	167-177	aryl hydrocarbon receptor	Homo sapiens	114-117
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	279-289	aryl hydrocarbon receptor	Homo sapiens	114-117
17418997-10	2007	A significant correlation between the creatinine clearance and the cystatin C does exist, but the correlation coefficient was low.	Creatinine	38-48	cystatin C	Homo sapiens	67-77
17388597-7	2007	The isolable oxorhenium(V) hydride 4a reacts with PhCHO to afford the alkoxide Re(O)Cl2(OCH2Ph)(PPh3)2 (6a) with kinetic dependencies that are consistent with aldehyde coordination followed by aldehyde insertion into the Re-H bond.	Creatinine	27-34	carboxylesterase 1	Homo sapiens	221-225
17388960-6	2007	A serum cystatin C level cut-off &gt; 82.1 nmol/l (1.10 mg/l) had the best test characteristics as a screening tool for detecting moderate CKD (&lt; 60 ml/min per 1.73 m(2)) when compared with creatinine-based methods.	Creatinine	193-203	cystatin C	Homo sapiens	8-18
17378999-8	2007	There was a significant negative correlation between the log10-transformed (log) plasma visfatin concentration and FMD or creatinine clearance (R=-0.2672, P=.0167; R=-0.2750, P=.0136).	Creatinine	122-132	nicotinamide phosphoribosyltransferase	Homo sapiens	88-96
17378999-11	2007	In stepwise regression analysis, creatinine clearance, log aldosterone, FMD, and sex showed a significant association with log visfatin (P=.0040, P=.0069, P=.0444, and P=.0487, respectively), and log 8-iso-prostaglandin F2alpha showed a tendency for an association (P=.0515).	Creatinine	33-43	nicotinamide phosphoribosyltransferase	Homo sapiens	127-135
17378999-13	2007	In conclusion, the current study showed that visfatin is negatively associated with vascular endothelial function evaluated by FMD and creatinine clearance, and positively associated with log urinary albumin excretion.	Creatinine	135-145	nicotinamide phosphoribosyltransferase	Homo sapiens	45-53
17306939-5	2007	Further, the prevalence rates for urinary NAG above 8 units/g creatinine (NAG-uria) increased with exposure levels in a dose dependent manner (p=0.05) among subjects with disease.	Creatinine	62-72	O-GlcNAcase	Homo sapiens	42-45
17306939-5	2007	Further, the prevalence rates for urinary NAG above 8 units/g creatinine (NAG-uria) increased with exposure levels in a dose dependent manner (p=0.05) among subjects with disease.	Creatinine	62-72	O-GlcNAcase	Homo sapiens	74-77
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	70-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	46-51
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	70-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-87
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	142-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	46-51
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	142-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-87
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	142-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	46-51
17306939-6	2007	In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and &gt;10 microg/g creatinine).	Creatinine	142-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-87
17183246-5	2007	In adjusted analyses, cystatin C concentrations appeared to have stronger associations with each biomarker compared with estimated glomerular filtration rate or serum creatinine.	Creatinine	167-177	cystatin C	Homo sapiens	22-32
17479706-7	2007	In univariate analysis, BNP was associated with left ventricular systolic dysfunction (LVSD), moderate to severe valvular abnormalities, left atrial diameter/body surface area, left ventricular mass index, systolic blood pressure, lower creatinine clearance and jugular venous distension.	Creatinine	237-247	natriuretic peptide B	Homo sapiens	24-27
16962271-4	2007	The liver weights and the body growth were reduced by the diet supplemented with Dai-saiko-to, which slightly affected the concentrations of total protein, albumin, creatinine or calcium, and the activity of lactate dehydrogenase.	Creatinine	165-175	Z-DNA binding protein 1	Mus musculus	81-84
17591727-7	2007	Additionally, inner-sphere electron-transfer reactions take place for a few systems, that is, the delivery of hydride or methanide ions from the hydrocarbon to NiX+ in the course of which the hydrocarbon is converted to a carbenium ion and the cationic metal complex gives rise to a neutral RNiX molecule (R=H, CH3).	Creatinine	110-117	BCL2 interacting protein 3 like	Homo sapiens	160-163
17519026-5	2007	The inverses of serum creatinine, cystatin C, and B2M were correlated with creatinine clearance (CrC) using a 24-hour urine sample and CrC estimation by Schwartz formula (Schwartz).	Creatinine	75-85	cystatin C	Homo sapiens	34-44
17581273-2	2007	Herrero-Morin and colleagues performed a cross-sectional analysis of the ability of cystatin C and beta2 microglobulin to reflect creatinine clearance in pediatric patients with AKI.	Creatinine	130-140	cystatin C	Homo sapiens	84-94
17653600-7	2007	Serum creatinine was positively associated with microalbuminuria in men (beta = 2.50, 95% confidence interval (CI) 0.66-4.34), but not in women.	Creatinine	6-16	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	73-81
17636214-10	2007	In addition, serum cystatin C levels positively correlate with respective creatinine and urea levels in the perinatal period.	Creatinine	74-84	cystatin C	Homo sapiens	19-29
17853021-8	2007	Patients with interstitial, mesangial and perivascular elastase deposits had significantly higher serum creatinine than those without.	Creatinine	104-114	elastase, neutrophil expressed	Homo sapiens	55-63
17198276-11	2006	In comparison with control mice, serum levels of creatinine and BUN were also significantly decreased in C3 and caspase 3 siRNA-treated mice.	Creatinine	49-59	complement component 3	Mus musculus	105-107
17171797-6	2006	Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and creatinine in SAP.	Creatinine	104-114	high mobility group box 1	Mus musculus	5-10
17046851-7	2006	BNP concentration before volume infusion significantly correlated to preoperative left ventricular ejection fraction, aortic cross-clamping time, serum creatinine, mean pulmonary arterial pressure and intensive care unit duration whereas no correlation was found with pulmonary-artery occlusion pressure or cardiac index.	Creatinine	152-162	natriuretic peptide B	Homo sapiens	0-3
16876777-7	2006	Using adjusted CCR as "golden standard", cystatin C was superior to creatinine in diagnosing renal dysfunction (area under the curve [AUC] for cystatin C 0.876, 95% confidence interval 81.8-93.4; AUC for creatinine 0.801, 95% confidence interval 72.5-87.7; p=0.045).	Creatinine	204-214	cystatin C	Homo sapiens	41-51
17175366-11	2006	CONCLUSIONS: Intraoperative BNP infusion in heart transplant recipients was associated with favorable postoperative hemodynamics, significantly improved urine output, and stable serum creatinine levels.	Creatinine	184-194	natriuretic peptide B	Homo sapiens	28-31
16860526-9	2006	BNP levels were higher in 10 patients with ACP: 585.5 [189-4830] vs 145.5 [36.5-346] pg/ml (P=0.01) but in those with creatinine clearance &lt; 90 ml/min: 602 [331-3530] vs 125 [39-189] pg/ml (P=0.007).	Creatinine	118-128	natriuretic peptide B	Homo sapiens	0-3
16860526-10	2006	BNP was correlated with RVA (r=0.5; p=0.01), RVA/LVA ratio (r=0.61; p=0.001), sPAP (r=0.58; p=0.002) and with age, cardiac index and creatinine clearance (r=0.61; p=0.001).	Creatinine	133-143	natriuretic peptide B	Homo sapiens	0-3
16860526-11	2006	In multivariate analysis, BNP was only correlated with creatinine clearance (p=0.03), and RVA (p=0.06).	Creatinine	55-65	natriuretic peptide B	Homo sapiens	26-29
16807400-9	2006	Ammonium chloride-induced intracellular acidification significantly stimulated the hMATE2-K-dependent transport of organic cations such as TEA, MPP, procainamide, metformin, N1-methylnicotinamide, creatinine, guanidine, quinidine, quinine, thiamine, and verapamil.	Creatinine	197-207	solute carrier family 47 member 2	Homo sapiens	83-89
16835061-7	2006	RESULTS: For both NAG and protein HC, the BMDs (BMDLs) of U-Cd were 0.5-1.1 (0.4-0.8) microg/L (adjusted for specific gravity of 1.015 g/mL) and 0.6-1.1 (0.5-0.8) microg/g creatinine.	Creatinine	172-182	alpha-1-microglobulin/bikunin precursor	Homo sapiens	26-36
16524933-8	2006	The receiver operating characteristic (ROC) curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C had a significantly higher diagnostic accuracy than serum creatinine (P = 0.04) and calculated creatinine clearance from the C&amp;G formula (P &lt; 0.0001), though only in female patients.	Creatinine	219-229	cystatin C	Homo sapiens	113-123
16501491-8	2006	Cystatin-C and serum beta(2)-M showed a strong correlation with creatinine clearance and age, while NAG positively correlated with proteinuria.	Creatinine	64-74	cystatin C	Homo sapiens	0-10
16778715-9	2006	The GFR (mean+/-SD; median) predicted by the serum creatinine (84.0+/-35.1 mL/min/1.73 m; 82.6 mL/min/1.73 m) was significantly higher (P&lt;0.001) than that predicted by the serum cystatin C (53.1+/-30.2 mL/min/1.73 m; 44.9 mL/min/1.73 m).	Creatinine	51-61	cystatin C	Homo sapiens	181-191
16778715-10	2006	The ratio between the GFR values predicted by creatinine and cystatin C had a highly significant negative correlation with the rate of creatinine production (r=-0.912, P&lt;0.001).	Creatinine	135-145	cystatin C	Homo sapiens	61-71
16380255-0	2006	Phenyl ureas of creatinine as mGluR5 antagonists.	Creatinine	16-26	glutamate receptor, ionotropic, kainate 1	Mus musculus	30-36
16408133-12	2006	Averaged estimates between cystatin C and serum creatinine equations further improved correlation (r(2)=0.891).	Creatinine	48-58	cystatin C	Homo sapiens	27-37
15613621-5	2005	Urinary excretion of albumin, determined by EIA, was remarkably increased in the 129/COX-2-/- (16.4 +/- 4.1 vs. 0.16 +/- 0.043 mg albumin/mg creatinine, P &lt; 0.001), and to a lesser extent in the male C57/COX-2-/- mice (0.595 +/- 0.416 vs. 0.068 +/- 0.019).	Creatinine	141-151	cytochrome c oxidase II, mitochondrial	Mus musculus	85-90
16176176-6	2005	Cystatin C correlated with creatinine (0.856, p&lt;0.0001) and CG CrCl with MDRD GFR (0.926, p&lt;0.0001) in renal failure (10-78 mL/min, n=60).	Creatinine	27-37	cystatin C	Homo sapiens	0-10
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	50-60	cystatin C	Homo sapiens	30-34
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	84-94	cystatin C	Homo sapiens	30-34
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	84-94	cystatin C	Homo sapiens	30-34
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	84-94	cystatin C	Homo sapiens	30-34
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	84-94	cystatin C	Homo sapiens	30-34
16201897-5	2005	Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; -0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group.	Creatinine	84-94	cystatin C	Homo sapiens	30-34
15579510-5	2004	In an established murine model of renal ischemia-reperfusion injury, intravenous NGAL administered before, during, or after ischemia resulted in marked amelioration of the morphologic and functional consequences, as evidenced by a significant decrease in the histopathologic damage to tubules and in serum creatinine measurements.	Creatinine	306-316	lipocalin 2	Mus musculus	81-85
15743027-11	2004	Increased urinary NAG is accompanied by a decrease in serum creatinine which is consistent with hyperfiltration.	Creatinine	60-70	O-GlcNAcase	Homo sapiens	18-21
15542278-6	2004	RESULTS: Elevated plasma levels of OPG at baseline were associated with adverse outcomes during a median of 27 months follow-up; OPG remained an independent prognostic indicator also after adjustment for other known predictors of mortality and cardiovascular events after AMI (e.g., creatinine clearance, N-terminal B-type natriuretic peptide, high-sensitivity C-reactive protein).	Creatinine	283-293	TNF receptor superfamily member 11b	Homo sapiens	35-38
15542278-6	2004	RESULTS: Elevated plasma levels of OPG at baseline were associated with adverse outcomes during a median of 27 months follow-up; OPG remained an independent prognostic indicator also after adjustment for other known predictors of mortality and cardiovascular events after AMI (e.g., creatinine clearance, N-terminal B-type natriuretic peptide, high-sensitivity C-reactive protein).	Creatinine	283-293	TNF receptor superfamily member 11b	Homo sapiens	129-132
15465024-2	2004	Treatment with G-CSF significantly ameliorated both BUN and serum creatinine increase induced by cisplatin administration with concomitant alleviation in the degree of necrotic change, enhancement in DNA synthesis, and decrease in apoptosis of renal tubular cells.	Creatinine	66-76	colony stimulating factor 3 (granulocyte)	Mus musculus	15-20
15672789-8	2004	The increased urinary NAG/creatinine ratio in patients with severe sepsis may reflect proximal tubular dysfunction.	Creatinine	26-36	O-GlcNAcase	Homo sapiens	22-25
15103314-9	2004	Systolic and pulse pressure ABP values correlated significantly with serum creatinine levels at baseline and 3 years thereafter, independent of daytime (r = 0.23-0.60; P &lt; 0.05).	Creatinine	75-85	amine oxidase copper containing 1	Homo sapiens	28-31
15103314-10	2004	Abnormal nocturnal systolic and mean ABP, and pulse pressure but not average day office BP were significantly associated with abnormal serum creatinine and the presence of coronary heart disease at baseline (relative risk 1.6-1.7, P &lt; 0.05).	Creatinine	141-151	amine oxidase copper containing 1	Homo sapiens	37-40
15480901-14	2004	CONCLUSIONS: In the present study, in advanced IgAN patients whose creatinine clearance was under 70 ml/min, steroid therapy effectively reduced the amount of proteinuria and maintained the serum creatinine level, if the treatment was selectively applied to patients with a moderate amount of proteinuria and active glomerular lesions such as cellular and fibrocellular crescents, and mesangial cell proliferation.	Creatinine	67-77	IGAN1	Homo sapiens	47-51
15481848-8	2004	Creatinine clearance (Ccr) in IgAN with 4G/4G was significantly lower than IgAN with 4G/5G or 5G/5G (72.3 +/- 26.5 and 82.4 +/- 22.8 ml/min, respectively, p &lt; 0.05).	Creatinine	0-10	IGAN1	Homo sapiens	30-34
15481859-0	2004	The shorter T1/2 of cystatin C explains the earlier change of its serum level compared to serum creatinine.	Creatinine	96-106	cystatin C	Homo sapiens	20-30
15223905-9	2004	RESULTS: Granulysin mRNA increase (vs. 95% confidence interval of 159 urine samples from nonrejecting patients) was detected during 11 of 14 aRx episodes, and follow-up studies showed its predictive value for delayed aRx episodes, even weeks before enhanced serum creatinine was observed.	Creatinine	264-274	granulysin	Homo sapiens	9-19
15194452-4	2004	The ET(B)-deficient sl/sl rats exhibited earlier and higher increases in systolic blood pressure, urinary protein excretion, blood urea nitrogen and plasma creatinine concentration, compared with cases in wild-type rats.	Creatinine	156-166	endothelin receptor type B	Rattus norvegicus	4-9
15145115-11	2004	Log biopyrrins/creatinine levels were positively correlated with log BNP levels (r = 0.650, p &lt; 0.001).	Creatinine	15-25	natriuretic peptide B	Homo sapiens	69-72
15112193-10	2004	Proteinuria and the serum levels of creatinine were improved concomitant with normalization of the serum complement levels and the decrease in serum PR3-ANCA titer.	Creatinine	36-46	proteinase 3	Homo sapiens	149-152
15111539-6	2004	Stepwise regression analysis revealed contribution of albuminuria, creatinine clearance, and duration of diabetes as predictors of plasma CTGF-N level.	Creatinine	67-77	cellular communication network factor 2	Homo sapiens	138-144
15111539-8	2004	CONCLUSIONS: Plasma CTGF-N levels are elevated in type 1 diabetic patients with nephropathy and appear to be correlated with proteinuria and creatinine clearance.	Creatinine	141-151	cellular communication network factor 2	Homo sapiens	20-26
14709451-7	2004	Sensitivity and specificity were 92% (95% confidence interval, 83-96%) and 83% (73-90%), respectively, for urinary cystatin C &gt;1 g/mol of creatinine, and 88% (78-93%) and 81% (70-88%) for urinary alpha(1)-microglobulin &gt;20 g/mol of creatinine.	Creatinine	238-248	cystatin C	Homo sapiens	115-125
14533978-5	2004	The main limitations of the study were that the sample of heart failure patients comprised only 34 individuals with New York Heart Association functional Class IV and that the observed correlation between levels of urinary N-BNP and plasma creatinine seemed counter-intuitive.	Creatinine	240-250	natriuretic peptide B	Homo sapiens	225-228
14760795-9	2004	Serum MIF was also negatively associated with serum creatinine concentration, independent of disease damage and corticosteroid dose.	Creatinine	52-62	macrophage migration inhibitory factor	Homo sapiens	6-9
14717912-9	2004	This was demonstrated in that mathematically generated theoretical values of serum creatinine and creatinine clearance correlated significantly with actual IgAN patient values of serum creatinine and creatinine clearance.	Creatinine	83-93	IGAN1	Homo sapiens	156-160
14717912-9	2004	This was demonstrated in that mathematically generated theoretical values of serum creatinine and creatinine clearance correlated significantly with actual IgAN patient values of serum creatinine and creatinine clearance.	Creatinine	98-108	IGAN1	Homo sapiens	156-160
14717912-9	2004	This was demonstrated in that mathematically generated theoretical values of serum creatinine and creatinine clearance correlated significantly with actual IgAN patient values of serum creatinine and creatinine clearance.	Creatinine	98-108	IGAN1	Homo sapiens	156-160
14717912-9	2004	This was demonstrated in that mathematically generated theoretical values of serum creatinine and creatinine clearance correlated significantly with actual IgAN patient values of serum creatinine and creatinine clearance.	Creatinine	98-108	IGAN1	Homo sapiens	156-160
15331941-11	2004	Univariate analysis in these patients without known cardiomyopathy showed that N-BNP levels also correlated with systolic and diastolic blood pressure (r: 0.54; p &lt; 0.005) and inversely with creatinine clearance (r: -0.43; p &lt; 0.01), serum albumin (r: 0.6; p &lt; 0.001) and hemoglobin levels (r: 0.37; p &lt; 0.05).	Creatinine	194-204	natriuretic peptide B	Homo sapiens	81-84
15518324-9	2004	Determining cystatin C concentrations as a protein which probably does not undergo glycation in plasma, may play a role in the detection of early diabetic nephropathy, when as well as plasma creatinine levels and albumin/creatinine index calculated from a sample of morning urine do not differentiate the studied group of patients.	Creatinine	191-201	cystatin C	Homo sapiens	12-22
15724929-10	2004	Blood beta-thromboglobulin directly correlated with systolic and diastolic arterial pressure, 24-h proteinuria and blood creatinine.	Creatinine	121-131	pro-platelet basic protein	Homo sapiens	6-26
15013312-5	2004	Cystatin C and B(2)M correlated significantly with creatinine (r =.648, P &lt;.05 and r =.578, P &lt;.05, respectively).	Creatinine	51-61	cystatin C	Homo sapiens	0-10
12880536-7	2003	RESULTS: In patients with SCI, the reciprocal of cystatin C had a stronger correlation (r = 0.48, P&lt;0.01) with creatinine clearance than the reciprocal of serum creatinine (r = 0.25, P&lt;0.19).	Creatinine	114-124	cystatin C	Homo sapiens	49-59
12875343-13	2003	The raised NAG values in urine and normal serum urea and creatinine levels during treatment with gentamicin without concomitant clinical symptoms of renal failure suggest subclinical destruction of the renal tubules.	Creatinine	57-67	O-GlcNAcase	Homo sapiens	11-14
12826215-13	2003	CONCLUSIONS: Conversion from AZA to MMF after CSA reduction improves creatinine clearance in HTX recipients and reduces serum creatinine.	Creatinine	126-136	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	46-49
12746126-11	2003	The only positive correlation was found between the urinary excretion of NAG activity (standardized for BMI and urinary creatinine) and Cd-B levels when taking the whole children population, indicating that even low cadmium burdens may produce subtle effects on the proximal tubule in children, although deleterious consequences are unlikely should exposure not increase.	Creatinine	120-130	O-GlcNAcase	Homo sapiens	73-76
12753883-1	2003	Many clinicians are uncomfortable about using angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (AT(1)-blockers) to treat patients with renal disease because of concerns about increasing serum creatinine levels.	Creatinine	233-243	angiotensin II receptor type 1	Homo sapiens	96-126
12812644-18	2003	CONCLUSION: In patients with IgAN, vascular lesion parallels the blood pressure, serum triglyceride, urine protein, serum creatinine, etc.	Creatinine	122-132	IGAN1	Homo sapiens	29-33
12558316-7	2003	The lowest value of pHi during CPB was significantly related to blood urea nitrogen (r = -0.75, p &lt; 0.05), serum creatinine (r = -0.78, p &lt; 0.05), creatinine clearance (r = 0.68, p &lt; 0.05) on postoperative day 1, and blood urea nitrogen (r = -0.84, p &lt; 0.01) on day 3.	Creatinine	116-126	glucose-6-phosphate isomerase	Homo sapiens	20-23
12558316-7	2003	The lowest value of pHi during CPB was significantly related to blood urea nitrogen (r = -0.75, p &lt; 0.05), serum creatinine (r = -0.78, p &lt; 0.05), creatinine clearance (r = 0.68, p &lt; 0.05) on postoperative day 1, and blood urea nitrogen (r = -0.84, p &lt; 0.01) on day 3.	Creatinine	153-163	glucose-6-phosphate isomerase	Homo sapiens	20-23
14718745-8	2003	This study showed that the increase in HMW-apo(a) was closely accompanied by the increase in serum creatinine levels, and the serum Lp(a) concentration with HMW-apo(a) was higher according to their creatinine levels.	Creatinine	198-208	lipoprotein(a)	Homo sapiens	132-137
12401747-10	2002	The reliability of cystatin C, as assessed by the discriminant ratio, was superior to creatinine clearance (3.4 vs. 1.5, P &lt; 0.001) and the correlation of cystatin C with iohexol clearance (Rs -0.80) was similar to that of creatinine clearance (Rs -0.74) and superior to that of plasma creatinine and the Cockcroft-Gault estimate (Rs -0.54 and 0.66, respectively).	Creatinine	226-236	cystatin C	Homo sapiens	19-29
12401747-10	2002	The reliability of cystatin C, as assessed by the discriminant ratio, was superior to creatinine clearance (3.4 vs. 1.5, P &lt; 0.001) and the correlation of cystatin C with iohexol clearance (Rs -0.80) was similar to that of creatinine clearance (Rs -0.74) and superior to that of plasma creatinine and the Cockcroft-Gault estimate (Rs -0.54 and 0.66, respectively).	Creatinine	226-236	cystatin C	Homo sapiens	19-29
12401747-12	2002	CONCLUSIONS-Based on this study, cystatin C is a more reliable measure of GFR than creatinine clearance, is more highly correlated with iohexol clearance than plasma creatinine, and is worthy of further investigation as a clinical measure of GFR in type 1 diabetes.	Creatinine	166-176	cystatin C	Homo sapiens	33-43
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	pro-platelet basic protein	Homo sapiens	235-255
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	pro-platelet basic protein	Homo sapiens	257-264
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	platelet factor 4	Homo sapiens	289-293
12487162-4	2002	RESULTS: There was a significant positive correlation between serum cystatin C and creatinine levels (r=0.928).	Creatinine	83-93	cystatin C	Homo sapiens	68-78
12487162-5	2002	Serum cystatin C was inversely correlated with creatinine clearance.	Creatinine	47-57	cystatin C	Homo sapiens	6-16
12487162-7	2002	The receiver-operating characteristic curve of serum cystatin C and creatinine demonstrated that the diagnostic accuracy of the serum cystatin C level is superior to that of creatinine in identifying individuals with reduced GFR.	Creatinine	68-78	cystatin C	Homo sapiens	134-144
12393844-7	2002	In addition, IL-18 antiserum-treated neutrophil-depleted mice with ischemic ARF had a significant (75%) reduction in serum creatinine and a significant reduction in ATN score compared with vehicle-treated neutrophil-depleted mice.	Creatinine	123-133	interleukin 18	Mus musculus	13-18
12211652-8	2002	In this study we observed that BK, determined as antitryptic activity, was clearly increased in urine from 35 patients with inflammatory diseases varying in origin and severity (76.5 +/- 75.5 IU/g vs. reference value &lt;10 IU/g creatinine).	Creatinine	229-239	alpha-1-microglobulin/bikunin precursor	Homo sapiens	31-33
12021530-7	2002	There was a high correlation between COX-2 and creatinine clearance (r = -0.845).	Creatinine	47-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	37-42
12027139-7	2002	After insulin application we observed the increase of creatinine and glucose peritoneal transport rate.	Creatinine	54-64	insulin	Oryctolagus cuniculus	6-13
11877571-4	2002	Serum OCIF levels in predialysis patients increased as renal function declined (OCIF = 1.178 + 0.233 x creatinine; r2 = 0.413; P &lt; 0.0001).	Creatinine	103-113	TNF receptor superfamily member 11b	Homo sapiens	6-10
11983344-11	2002	We recommend an upper reference limit for uristatin by dipstick of &lt; or = 7.5 mg uristatin/g creatinine.	Creatinine	96-106	alpha-1-microglobulin/bikunin precursor	Homo sapiens	42-51
11840382-8	2002	The NAG-to-Cr, TP-to-Cr, and Alb-to-Cr ratios were significantly higher in group 3 than in group 2.	Creatinine	11-13	O-GlcNAcase	Homo sapiens	4-7
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	148-150	O-GlcNAcase	Homo sapiens	141-144
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	148-150	O-GlcNAcase	Homo sapiens	141-144
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	148-150	O-GlcNAcase	Homo sapiens	141-144
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	148-150	O-GlcNAcase	Homo sapiens	141-144
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	148-150	O-GlcNAcase	Homo sapiens	141-144
11840382-12	2002	The percent increases in the NAG-to-Cr and beta2MG-to-Cr ratios rose markedly in normotensive pregnancy, whereas percent increases of the Alb-to-Cr and TP-to-Cr ratios were far greater in preeclampsia than in normotensive pregnancy.	Creatinine	36-38	O-GlcNAcase	Homo sapiens	29-32
11913598-9	2002	Change in urinary sodium-to-creatinine ratios of 3 consecutive pooled overnight 8-hour urine collections correlated with changes in 24-hour ambulatory SBP (r = 0.294, P&lt;.001) and DBP (r = 0.193, P&lt;.05); however, change in total urinary sodium content was uncorrelated.	Creatinine	28-38	selenium binding protein 1	Homo sapiens	151-154
11848433-6	2001	Similar results were obtained for MHC class II antigen expression by TEC and these results were correlated with serum creatinine values.	Creatinine	118-128	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	34-54
10521815-7	1999	The H-hCG elevation in affected pregnancies was more marked at 14 weeks" gestation or later: a median of 4.64 MoM and allowing for creatinine bias 4.46 MoM.	Creatinine	131-141	chorionic gonadotropin subunit beta 5	Homo sapiens	6-9
10515373-11	1999	Creatinine clearance was higher in animals treated with the selective ET-A receptor antagonist (P&lt;0.05).	Creatinine	0-10	endothelin receptor type A	Rattus norvegicus	70-74
10479668-0	1999	Cystatin C as a determinant of fasting plasma total homocysteine levels in coronary artery disease patients with normal serum creatinine.	Creatinine	126-136	cystatin C	Homo sapiens	0-10
10479668-2	1999	We hypothesized that among stable-CAD patients with normal creatinine levels (ie, &lt;/=1.4 mg/dL), serum cystatin C, a more sensitive indicator of glomerular filtration rate, would better predict fasting total homocysteine levels in comparison with serum creatinine.	Creatinine	59-69	cystatin C	Homo sapiens	106-116
10479668-2	1999	We hypothesized that among stable-CAD patients with normal creatinine levels (ie, &lt;/=1.4 mg/dL), serum cystatin C, a more sensitive indicator of glomerular filtration rate, would better predict fasting total homocysteine levels in comparison with serum creatinine.	Creatinine	256-266	cystatin C	Homo sapiens	106-116
10479668-9	1999	We conclude that serum cystatin C levels may reflect subtle decreases in renal function that independently predict fasting total homocysteine levels among stable-CAD patients with normal serum creatinine.	Creatinine	193-203	cystatin C	Homo sapiens	23-33
10554151-3	1999	INAP (median=4.2 microg/l and 3.3 microg/g creatinine) and TCPY (median=5.3 microg/l and 4.6. microg/g creatinine) were present in over 80% of the samples, while MDA and AM were detected infrequently (6.6% and &lt;1% of samples, respectively).	Creatinine	43-53	NFKB inhibitor zeta	Homo sapiens	0-4
10469373-7	1999	Lp(a) levels were significantly greater in patients with moderate renal failure (21.7+/-23.9 mg/dl) as compared with patients with normal renal function (15.6+/-16.4 mg/dl, P&lt;0.001), and an inverse correlation was observed between log Lp(a) and creatinine clearance (r = -0.181, P &lt;0.01).	Creatinine	248-258	lipoprotein(a)	Homo sapiens	0-5
10645027-6	1999	Serum creatinine levels and creatinine clearance correlated with pHi in the patient"s group.	Creatinine	6-16	glucose-6-phosphate isomerase	Homo sapiens	65-68
10645027-6	1999	Serum creatinine levels and creatinine clearance correlated with pHi in the patient"s group.	Creatinine	28-38	glucose-6-phosphate isomerase	Homo sapiens	65-68
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	74-77
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	45-55	O-GlcNAcase	Homo sapiens	152-155
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	74-77
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	152-155
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	74-77
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	152-155
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	74-77
10452282-10	1999	There was an inverse correlation between the creatinine clearance and the NAG/creatinine ratio, i.e., a high creatinine clearance correlated with a low NAG/creatinine ratio.	Creatinine	78-88	O-GlcNAcase	Homo sapiens	152-155
10411681-5	1999	RESULTS: Control opn +/+ mice showed a significant retention of blood urea nitrogen and creatinine, which is indicative of the development of ischemic acute renal dysfunction.	Creatinine	88-98	secreted phosphoprotein 1	Mus musculus	17-20
10494674-5	1999	CCB+TRH reduced the concentrations of serum urea and creatinine, the degree of pancreatic damage, and increased PO2 and serum calcium concentration.	Creatinine	53-63	thyrotropin releasing hormone	Rattus norvegicus	4-7
10412858-4	1999	After 90 days, urine protein, creatinine ratio was significantly (P&lt;0.05) increased in GH-treated AN (95.2+/-13.9) compared with untreated AN (64.8+/-7.8) and GH-treated AN rats plus CAP (41.8+/-8.8).	Creatinine	30-40	gonadotropin releasing hormone receptor	Rattus norvegicus	90-92
11400755-1	1999	We found a 4-year-old boy in the screened cohort, who showed a low ceruloplasmin (CP) in urine (17 ng/mg-creatinine) and in blood (0.6 mg/dl), but his urine copper was in the normal range.	Creatinine	105-115	ceruloplasmin	Homo sapiens	67-80
11400755-1	1999	We found a 4-year-old boy in the screened cohort, who showed a low ceruloplasmin (CP) in urine (17 ng/mg-creatinine) and in blood (0.6 mg/dl), but his urine copper was in the normal range.	Creatinine	105-115	ceruloplasmin	Homo sapiens	82-84
9817704-8	1998	In contrast, whereas the clearances of both CC16 and cystatin C were related to that of creatinine (p &lt; 0.02 for both), the clearances of SP-A and SP-B were not.	Creatinine	88-98	secretoglobin family 1A member 1	Homo sapiens	44-48
9777464-5	1998	Chitosan encapsulated activated charcoal (ACCB) beads have been extensively investigated in our group for the removal of various toxins such as urea, creatinine, uric acid, bilirubin, etc.	Creatinine	150-160	acetyl-CoA carboxylase beta	Homo sapiens	42-46
9771845-6	1998	Allografts with depleted tubular antithrombin at transplantation (n=20) had significantly greater plasma creatinine concentrations at posttransplant days 3 (P &lt; 0.001) and 5 (P &lt; 0.03) than allografts with normal tubular antithrombin (n=21).	Creatinine	105-115	serpin family C member 1	Homo sapiens	33-45
9554559-5	1998	In rats with iARF, IGF-I ameliorates the rise in serum creatinine, improves GFR, increases the rate of bromodeoxyuridine (BrdU) incorporation and the mitosis score, and reduces the number of apoptotic bodies.	Creatinine	55-65	insulin-like growth factor 1	Rattus norvegicus	19-24
9294826-6	1997	The mean urinary AQP2 concentration corrected for creatinine in spot urine samples of healthy subjects who voided in the morning was 1081 +/- 699 fmol/mg creatinine (mean +/- SD, n = 208).	Creatinine	154-164	aquaporin 2	Homo sapiens	17-21
9278197-6	1997	Interindividual variability of DS-Fab total body clearance was linked linearly with the decrease in creatinine clearance or with the increase in age and DS-Fab distribution volume was not dependent on creatinine clearance or age.	Creatinine	100-110	FA complementation group B	Homo sapiens	34-37
9202163-3	1997	An increase in urinary 8-OHdG/creatinine was found in non-small-cell carcinoma (non-SCC) patients during the course of radiotherapy.	Creatinine	30-40	serpin family B member 3	Homo sapiens	84-87
9202163-4	1997	SCC patients showed higher levels of urinary 8-OHdG/creatinine than the controls.	Creatinine	52-62	serpin family B member 3	Homo sapiens	0-3
9202163-5	1997	Furthermore, SCC patients with complete or partial response to the chemotherapy showed a significant decrease in urinary 8-OHdG/creatinine while patients with no change or progressive disease showed an increase.	Creatinine	128-138	serpin family B member 3	Homo sapiens	13-16
9199820-8	1997	AT levels correlated with vWF (rs = - 0.73, P &lt; 0.01) and creatinine (Rs = -0.70, P &lt; 0.01).	Creatinine	61-71	serpin family C member 1	Homo sapiens	0-2
9200556-4	1997	The increases in plasma interleukin-1 and TNF-alpha levels evoked by lipopolysaccharide administration were also inhibited by treatment with FR167653, which was efficacious at doses of 0.1-0.32 mg/kg per h. In addition, FR167653 treatment attenuated the increases in plasma creatinine concentrations consistent with renal damage in a dose-dependent manner.	Creatinine	274-284	tumor necrosis factor	Oryctolagus cuniculus	42-51
9166281-10	1997	IL-10 administration induced a transient reduction in creatinine clearance of 35% at Day 3 (p &lt; 0.01).	Creatinine	54-64	interleukin 10	Rattus norvegicus	0-5
9237285-1	1997	OBJECTIVE: To establish whether estimation of creatinine clearance (CrCl) from serum creatinine, gender, age, and weight might reduce the number of 24-hour urine and dialysate collections required to monitor adequacy of delivered dialysis on continuous ambulatory peritoneal dialysis (CAPD).	Creatinine	46-56	CRCL	Homo sapiens	68-72
9237285-1	1997	OBJECTIVE: To establish whether estimation of creatinine clearance (CrCl) from serum creatinine, gender, age, and weight might reduce the number of 24-hour urine and dialysate collections required to monitor adequacy of delivered dialysis on continuous ambulatory peritoneal dialysis (CAPD).	Creatinine	85-95	CRCL	Homo sapiens	68-72
9175851-4	1997	The intraclass correlation coefficient (ICC) for urinary beta 2-microglobulin concentration, when expressed as microg/g creatinine and microg/l, was 0.92 and 0.89, respectively.	Creatinine	120-130	beta-2-microglobulin	Homo sapiens	57-77
9175851-6	1997	The findings suggest that single measurement of urinary beta 2-microglobulin and cadmium, when expressed as a function of creatinine, can reliably estimate average levels over at least a 3-year period.	Creatinine	122-132	beta-2-microglobulin	Homo sapiens	56-76
9112354-8	1997	There was a strong inverse correlation between PAP levels and creatinine clearance (P&lt;0.001).	Creatinine	62-72	regenerating family member 3 alpha	Homo sapiens	47-50
11571133-6	2001	ICAM-1 positive interstitial leucocytes were 234 (307)/mm2; this expression correlated with glomerulosclerosis, tubular atrophy, interstitial fibrosis and serum creatinine (Cr) level.	Creatinine	173-175	intercellular adhesion molecule 1	Homo sapiens	0-6
11571133-7	2001	In patients with 50% increase in Cr level, ICAM-1 positive interstitial leucocytes were 516 (360)/mm2 as compared with 66 (87.8)/mm2 (U = 16; p &lt; 0.005) in patients with stable Cr.	Creatinine	33-35	intercellular adhesion molecule 1	Homo sapiens	43-49
11692212-8	2001	In human renal biopsy samples, the IL-17 antigen could be found scattered around in the borderline changed rejected renal allografts without evidence of a serum creatinine increase, but was undetectable both in normal controls and in renal transplant tissue without signs of rejection.	Creatinine	161-171	interleukin 17A	Homo sapiens	35-40
9112354-13	1997	CONCLUSIONS: Serum PAP levels appear to strongly correlate with creatinine clearance measurements.	Creatinine	64-74	regenerating family member 3 alpha	Homo sapiens	19-22
11475347-6	2001	OUTCOME MEASURES: Loss of RRF was defined as the slope of the decline in GFR as measured by the average of creatinine and urea clearances in 24-hour urine collections.	Creatinine	107-117	Rap guanine nucleotide exchange factor 5	Homo sapiens	73-76
11231352-11	2001	Creatinine clearance (17.5 +/- 0.54 vs. 29.2 +/- 0.89 microL/min, P &lt; 0.001) was significantly worse in the adriamycin plus CD4(+) depletion mice than in adriamycin alone mice and correlated with histologic change in glomeruli and interstitium.	Creatinine	0-10	CD4 antigen	Mus musculus	127-130
11426671-8	2001	Creatinine and MDA levels and MPO activity were significantly lower and there was less histopathological damage in the AT group than in controls.	Creatinine	0-10	serpin family C member 1	Rattus norvegicus	119-121
11758675-3	2001	A double-blind placebo-controlled trial in 26 hemizygous male patients showed that agalsidase alfa (human alpha-Gal A) significantly reduced neuropathic pain (p = 0.02), increased creatinine clearance (p = 0.02), improved glomerular histology, reduced the QRS interval on electrocardiography and increased weight gain.	Creatinine	180-190	galactosidase alpha	Homo sapiens	83-98
10064360-4	1996	Does significant correlations between serum beta-2-M levels and serum creatinine levels or creatinine clearance (inulin clearance) exit?	Creatinine	70-80	beta-2-microglobulin	Homo sapiens	44-52
10064360-4	1996	Does significant correlations between serum beta-2-M levels and serum creatinine levels or creatinine clearance (inulin clearance) exit?	Creatinine	91-101	beta-2-microglobulin	Homo sapiens	44-52
9004108-8	1996	Patients in Renal Group I (creatinine clearance CrCl): 30-59 ml/min/1.73 m2) had decreases of -18/-16 and -25/-20 mm Hg after 12 weeks and 9 months of therapy, respectively.	Creatinine	27-37	CRCL	Homo sapiens	48-52
9099938-6	1996	The intense immunoreactivity for Jak3 is significantly associated with the decrease in creatinine clearance (81.5 +/- 10.4 ml/min versus 104.3 +/- 29.6 ml/min; P &lt; 0.05, Student"s t-test) and the increase in level of serum creatinine (1.13 +/- 0.33 mg/dl versus 0.75 +/- 0.23 mg/dl; P &lt; 0.01, Student"s t-test) in IgA-N patients.	Creatinine	87-97	Janus kinase 3	Homo sapiens	33-37
9099938-6	1996	The intense immunoreactivity for Jak3 is significantly associated with the decrease in creatinine clearance (81.5 +/- 10.4 ml/min versus 104.3 +/- 29.6 ml/min; P &lt; 0.05, Student"s t-test) and the increase in level of serum creatinine (1.13 +/- 0.33 mg/dl versus 0.75 +/- 0.23 mg/dl; P &lt; 0.01, Student"s t-test) in IgA-N patients.	Creatinine	226-236	Janus kinase 3	Homo sapiens	33-37
8671975-12	1996	The fractional excretion of MCP-1, calculated on the basis of MCP-1 and creatinine clearances, was found also to be significantly higher in the Rj group as compared to the NRj group.	Creatinine	72-82	C-C motif chemokine ligand 2	Homo sapiens	28-33
8604691-9	1996	Fifteen of 17 patients with serum creatinine greater than 1.4 mg/dL had myoglobin concentrations greater than 20,000 micrograms/L, whereas the remaining 31 patients with normal serum creatinine had urine myoglobin concentrations of less than 18,000 micrograms/L.	Creatinine	34-44	myoglobin	Homo sapiens	72-81
8604691-10	1996	If serum creatinine is used as an indicator of renal function, it would appear that accurate measurement of urine myoglobin may facilitate identification of patients with increased susceptibility to myoglobin-induced acute renal failure.	Creatinine	9-19	myoglobin	Homo sapiens	114-123
8604691-10	1996	If serum creatinine is used as an indicator of renal function, it would appear that accurate measurement of urine myoglobin may facilitate identification of patients with increased susceptibility to myoglobin-induced acute renal failure.	Creatinine	9-19	myoglobin	Homo sapiens	199-208
11758675-3	2001	A double-blind placebo-controlled trial in 26 hemizygous male patients showed that agalsidase alfa (human alpha-Gal A) significantly reduced neuropathic pain (p = 0.02), increased creatinine clearance (p = 0.02), improved glomerular histology, reduced the QRS interval on electrocardiography and increased weight gain.	Creatinine	180-190	galactosidase alpha	Homo sapiens	106-117
11887816-4	2001	RESULTS: The weekly mean total [PD + residual renal function (RRF)] creatinine clearance (C(Cr)) and Kt/V(urea) were 70.3 +/- 18 L per 1.73 m2 and 3.45 +/- 0.73, respectively.	Creatinine	68-78	mitochondrial ribosome recycling factor	Homo sapiens	62-65
8706303-14	1996	Creatinine and the reciprocal of 25OHD were other significant predictors with the final Ra2 = 39.4%, F = 17.7, P &lt; 0.001.	Creatinine	0-10	ribonucleotide reductase regulatory subunit M2	Homo sapiens	88-91
7600702-8	1995	For the latter application, done with split-sample measurements of a panel of 83 patients" specimens, we used the Boehringer Mannheim enzymatic creatinine PAP test on the Hitachi 911, the Kodak Ektachem single-slide enzymatic creatinine test on the Ektachem 700, the Merck Jaffe kinetic assay on the Mega analyzer, and the Roche Jaffe kinetic test on the Cobas Mira.	Creatinine	144-154	regenerating family member 3 alpha	Homo sapiens	155-158
7555533-10	1995	In addition, baseline spot urine ACR was independently related to 2-year plasma creatinine (P = 0.01) in the macroalbuminuric group.	Creatinine	80-90	acrosin	Homo sapiens	33-36
7537863-8	1995	In the five normal subjects tested, the mean (+/- SE) urinary excretion of aquaporin-2 was 11.2 +/- 2.2 pmol per milligram of creatinine after a period of dehydration, and it decreased to 3.9 +/- 1.9 pmol per milligram of creatinine (P = 0.03) during the second hour after a period of hydration.	Creatinine	126-136	aquaporin 2	Homo sapiens	75-86
7537863-8	1995	In the five normal subjects tested, the mean (+/- SE) urinary excretion of aquaporin-2 was 11.2 +/- 2.2 pmol per milligram of creatinine after a period of dehydration, and it decreased to 3.9 +/- 1.9 pmol per milligram of creatinine (P = 0.03) during the second hour after a period of hydration.	Creatinine	222-232	aquaporin 2	Homo sapiens	75-86
7537863-9	1995	In the six other normal subjects, an infusion of desmopressin (1-desamino-8-D-arginine vasopressin) increased the urinary excretion of aquaporin-2 from 0.8 +/- 0.3 to 11.2 +/- 1.6 pmol per milligram of creatinine (P &lt; 0.001).	Creatinine	202-212	aquaporin 2	Homo sapiens	135-146
7543841-13	1995	Mildly elevated plasma creatinine levels are more commonly observed in aprotinin-treated patients; these changes are transient in the majority of patients.	Creatinine	23-33	pancreatic trypsin inhibitor	Bos taurus	71-80
8023974-3	1994	In rats that received IGF-I 24 h postischemia, serum creatinine and blood urea nitrogen (BUN) values were significantly lower during the subsequent 6 days than in vehicle-treated rats, and incorporation of 5-bromo-2"-deoxyuridine into tubular cells of the regenerating cortex, measured 48 h postischemia, was enhanced.	Creatinine	53-63	insulin-like growth factor 1	Rattus norvegicus	22-27
7947277-5	1994	In healthy subjects, plasma and urinary TF levels were found to be 149 +/- 72 pg/ml (n = 30) and 175 +/- 60 pg TF/urine creatinine mg (n = 95), respectively.	Creatinine	120-130	coagulation factor III, tissue factor	Homo sapiens	40-42
8062506-9	1994	Des-(1-3)-insulin-like growth factor-1 caused a lower and earlier peak in both serum creatinine and blood urea-nitrogen levels, and a more rapid and complete return toward basal values than in untreated animals.	Creatinine	85-95	insulin-like growth factor 1	Rattus norvegicus	10-38
8062506-10	1994	Also des-(1-3)-insulin-like growth factor-1 significantly increased creatinine clearance and reduced fractional excretion of filtered sodium.	Creatinine	68-78	insulin-like growth factor 1	Rattus norvegicus	15-43
7505809-12	1994	Nonhematologic toxicities such as increased creatinine concentration also prevented an increase in the RDI in the G-CSF arm.	Creatinine	44-54	colony stimulating factor 3	Homo sapiens	114-119
8072607-3	1994	The plasma TM/serum creatinine (TM/Cr) ratio was significantly higher in lupus GN patients than in PGD patients or normal controls.	Creatinine	20-30	thrombomodulin	Homo sapiens	32-34
8165642-5	1994	When the patients were stratified according to creatinine clearance rate, significant differences between the subgroups with severely and moderately impaired renal function were noted: the baseline levels of PAI activity and VWF were higher in patients with severe renal failure and the VWF response to DDAVP was significantly lower.	Creatinine	47-57	serpin family E member 1	Homo sapiens	208-211
8165642-7	1994	A series of 18 patients with adult-type polycystic kidney disease (APKD) with creatinine clearance rates in the same abnormal range as the GN patients, had lower mean PAI and a significantly higher mean scu-PA level.	Creatinine	78-88	serpin family E member 1	Homo sapiens	167-170
8155917-2	1993	EGF excretion showed a statistically significant increase from 6.0 +/- 2.5 to 14.1 +/- 4.9 micrograms/g creatinine (mean +/- 1 SD) during the investigation period.	Creatinine	104-114	epidermal growth factor	Homo sapiens	0-3
8314363-3	1993	A two-compartment open model was utilized for the analysis, assuming that the total body clearance of drug (ClB) is linearly correlated with endogeneous creatinine clearance (Clcr).	Creatinine	153-163	citramalyl-CoA lyase	Homo sapiens	108-111
8238010-3	1993	Urinary hEGF levels, corrected for urine creatinine concentrations, were significantly decreased in patients with ARF in the acute phase compared with normal control subjects (0.98 +/- 0.20 v 13.74 +/- 1.18 ng/mg creatinine, P &lt; 0.001), and subsequently increased during the recovery phase (6.10 +/- 0.73 ng/mg creatinine, P &lt; 0.001 v acute phase).	Creatinine	213-223	epidermal growth factor	Homo sapiens	8-12
8238010-3	1993	Urinary hEGF levels, corrected for urine creatinine concentrations, were significantly decreased in patients with ARF in the acute phase compared with normal control subjects (0.98 +/- 0.20 v 13.74 +/- 1.18 ng/mg creatinine, P &lt; 0.001), and subsequently increased during the recovery phase (6.10 +/- 0.73 ng/mg creatinine, P &lt; 0.001 v acute phase).	Creatinine	213-223	epidermal growth factor	Homo sapiens	8-12
8238010-4	1993	A significant positive correlation existed between urinary hEGF levels and creatinine clearance in patients with ARF (r = 0.66, P &lt; 0.001).	Creatinine	75-85	epidermal growth factor	Homo sapiens	59-63
10966932-5	2000	At 48 h postischemia, CD4/CD8-knockout (KO) mice had marked improvement in renal function compared with control C57BL/6 mice (serum creatinine: 0.7 +/- 0.4 vs. 2.5 +/- 0.3 mg/dl, respectively; P &lt; 0.05).	Creatinine	132-142	CD4 antigen	Mus musculus	22-25
10728365-10	2000	Urinary excretion rates of nitrate and cyclic GMP increased also significantly by 38 mumol/mmol creatinine (P = 0.027) and 65 nmol/mmol creatinine (P = 0.003), respectively.	Creatinine	96-106	5'-nucleotidase, cytosolic II	Homo sapiens	46-49
8250595-2	1993	The standardized mortality ratios of the urinary beta 2-microglobulin-positive subjects (&gt; 1,000 micrograms/g creatinine) of both sexes were higher than those of the general Japanese population, whereas the cumulative survival curves were lower than those of the urinary beta 2-microglobulin-negative group.	Creatinine	113-123	beta-2-microglobulin	Homo sapiens	49-69
7764334-3	1993	The average level of human M-CSF in urine from normal males (N = 71) and females (N = 46) was 3.94 +/- 1.78 ng/ml (2.85 +/- 1.15 micrograms/g creatinine), and 3.53 +/- 1.70 ng/ml (3.31 +/- 1.12 micrograms/g creatinine), respectively.	Creatinine	142-152	colony stimulating factor 1	Homo sapiens	27-32
7764334-3	1993	The average level of human M-CSF in urine from normal males (N = 71) and females (N = 46) was 3.94 +/- 1.78 ng/ml (2.85 +/- 1.15 micrograms/g creatinine), and 3.53 +/- 1.70 ng/ml (3.31 +/- 1.12 micrograms/g creatinine), respectively.	Creatinine	207-217	colony stimulating factor 1	Homo sapiens	27-32
8111143-6	1993	Creatinine clearance was significantly higher in the IGF-1 group than the LPS group and exceeded the control group (0.49 +/- 0.27, 0.36 +/- 0.14, and 0.65 +/- 0.27 ml.min-1.100(-1) g body wt) for control, LPS, and IGF-1, respectively (analysis of variance, p &lt; 0.05).	Creatinine	0-10	insulin-like growth factor 1	Rattus norvegicus	53-58
8111143-6	1993	Creatinine clearance was significantly higher in the IGF-1 group than the LPS group and exceeded the control group (0.49 +/- 0.27, 0.36 +/- 0.14, and 0.65 +/- 0.27 ml.min-1.100(-1) g body wt) for control, LPS, and IGF-1, respectively (analysis of variance, p &lt; 0.05).	Creatinine	0-10	insulin-like growth factor 1	Rattus norvegicus	214-219
8111143-7	1993	IGF-1 ameliorates the effects of endotoxin on kidney function as measured by creatinine clearance and urine output in endotoxemic parenterally fed rats.	Creatinine	77-87	insulin-like growth factor 1	Rattus norvegicus	0-5
8414330-7	1993	For prediction of elevated serum creatinine during the second year of life, the fetal urinary concentration of beta 2 microglobulin was both specific (0.83) and sensitive (0.80); sodium, chloride, and urea levels were sensitive (0.70 or greater) but lacked specificity (less than 0.65); and fetal urinary glucose, phosphorus, calcium, ammonium, and total proteins were specific (0.70 or greater) but lacked sensitivity (0.65 or less).	Creatinine	33-43	beta-2-microglobulin	Homo sapiens	111-131
8263676-3	1993	It seems the ACCB may be a good adsorbent system for the removal of toxic uric acid, creatinine, bilirubin, etc., from solutions; while larger molecules such as albumin are adsorbed less.	Creatinine	85-95	acetyl-CoA carboxylase beta	Homo sapiens	13-17
10728365-10	2000	Urinary excretion rates of nitrate and cyclic GMP increased also significantly by 38 mumol/mmol creatinine (P = 0.027) and 65 nmol/mmol creatinine (P = 0.003), respectively.	Creatinine	136-146	5'-nucleotidase, cytosolic II	Homo sapiens	46-49
11045255-6	2000	When correlations between corrected CA125AR and various parameters were evaluated, corrected CA125AR positively correlated with age, but negatively correlated with serum creatinine and albumin levels.	Creatinine	170-180	mucin 16, cell surface associated	Homo sapiens	36-43
10752495-2	2000	However, the determination of endogenous creatinine clearance (Clcr) from a 24-h urine collection is an unreliable and time-consuming procedure.	Creatinine	41-51	chymotrypsin C	Homo sapiens	63-67
10589700-8	1999	In addition, the serum creatinine at discharge was higher in PlA2-positive versus PlA2-negative patients (2.2 +/- 1.6 versus 1.5 +/- 0.6 mg/dl, respectively; P = 0.01), and the prevalence of proteinuria &gt;1.5 g/d 1 yr after transplantation was significantly higher among patients showing the PlA2 allele (16% versus 3%; P = 0.02).	Creatinine	23-33	phospholipase A2 group IIA	Homo sapiens	61-65
8255673-8	1993	Analysis of urinary IGF-II excretion based on creatinine output yielded similar results.	Creatinine	46-56	insulin like growth factor 2	Homo sapiens	20-26
8127790-9	1993	The significant positive correlation was found between plasma B2MG and creatinine levels in all examined patients.	Creatinine	71-81	beta-2-microglobulin	Homo sapiens	62-66
8267020-4	1993	IL2R and beta 2M correlated with serum creatinine, but not with proteinuria.	Creatinine	39-49	beta-2-microglobulin	Homo sapiens	9-16
8300004-5	1993	A significant positive correlation was observed between the plasma TM level and that of serum creatinine.	Creatinine	94-104	thrombomodulin	Homo sapiens	67-69
8450710-8	1993	In the patients with HbA1c value below 8%, the mean urinary hEGF level was lower in the patients whose urinary albumin level exceeded 1.7 mg/mmol.creatinine as compared with those whose urinary albumin excretion was below 1.7 mg/mmol.creatinine.	Creatinine	146-156	epidermal growth factor	Homo sapiens	60-64
8450710-8	1993	In the patients with HbA1c value below 8%, the mean urinary hEGF level was lower in the patients whose urinary albumin level exceeded 1.7 mg/mmol.creatinine as compared with those whose urinary albumin excretion was below 1.7 mg/mmol.creatinine.	Creatinine	234-244	epidermal growth factor	Homo sapiens	60-64
10589700-8	1999	In addition, the serum creatinine at discharge was higher in PlA2-positive versus PlA2-negative patients (2.2 +/- 1.6 versus 1.5 +/- 0.6 mg/dl, respectively; P = 0.01), and the prevalence of proteinuria &gt;1.5 g/d 1 yr after transplantation was significantly higher among patients showing the PlA2 allele (16% versus 3%; P = 0.02).	Creatinine	23-33	phospholipase A2 group IIA	Homo sapiens	82-86
10589700-8	1999	In addition, the serum creatinine at discharge was higher in PlA2-positive versus PlA2-negative patients (2.2 +/- 1.6 versus 1.5 +/- 0.6 mg/dl, respectively; P = 0.01), and the prevalence of proteinuria &gt;1.5 g/d 1 yr after transplantation was significantly higher among patients showing the PlA2 allele (16% versus 3%; P = 0.02).	Creatinine	23-33	phospholipase A2 group IIA	Homo sapiens	82-86
10589958-13	1999	After 2 years, those biopsies originally found to have evidence of fibrosis, tubular atrophy, or CD3gamma transcription had worsening graft function as determined by creatinine and glomerular filtration rate.	Creatinine	166-176	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	97-105
10550325-7	1999	Next, the inhibition of the PDGF-B/PDGFRs axis with either Trapidil or Ki6896, which was found to inhibit the phosphorylation of PDGFR-beta selectively, resulted in a rise of serum creatinine, higher mortality rate, abnormal regenerating process, and suppressed proliferation of tubular epithelial cells.	Creatinine	181-191	platelet derived growth factor subunit B	Rattus norvegicus	28-34
8469787-5	1993	Twenty-three days following cessation of rIL2 treatment, there was still a significant reduction in creatinine clearance compared with pretreatment values (p &lt; .01).	Creatinine	100-110	interleukin 2	Rattus norvegicus	41-45
1451339-4	1992	Both TG and apo-CIII showed a positive correlation with creatinine levels.	Creatinine	56-66	apolipoprotein C3	Homo sapiens	12-20
10550325-7	1999	Next, the inhibition of the PDGF-B/PDGFRs axis with either Trapidil or Ki6896, which was found to inhibit the phosphorylation of PDGFR-beta selectively, resulted in a rise of serum creatinine, higher mortality rate, abnormal regenerating process, and suppressed proliferation of tubular epithelial cells.	Creatinine	181-191	platelet derived growth factor receptor beta	Rattus norvegicus	129-139
10555096-6	1999	This 66% fall in renin secretion was associated with significant (P &lt; 0.05) increases in creatinine clearance (40%), renal blood flow (8%), urine flow (50%), and sodium excretion (17%).	Creatinine	92-102	renin	Canis lupus familiaris	17-22
10090820-6	1999	RESULTS: In the HAL group, blood ammonia and serum creatinine levels were significantly lower, and blood pressure and blood glucose levels significantly higher, than those in the control group.	Creatinine	51-61	histidine ammonia-lyase	Canis lupus familiaris	16-19
1424305-5	1992	Mean peak serum creatinine was significantly higher in the patients with high urine myoglobin (6.4 +/- 1.3 mg/dl) compared to those with low urine myoglobin (2.2 +/- 0.3 mg/dl), p &lt; 0.02.	Creatinine	16-26	myoglobin	Homo sapiens	84-93
1501651-4	1992	METHODS AND RESULTS: Plasminogen-activator inhibitor type 1 (PAI-1) in plasma was measured with an assay employing a specific monoclonal antibody in 40 consecutive children hospitalized with the hemolytic uremic syndrome: 12 who recovered adequate renal function (serum creatinine, less than or equal to 2.0 mg per deciliter [177 mumol per liter]) without dialysis, 23 who recovered adequate renal function after peritoneal dialysis, and 5 who did not recover adequate renal function after undergoing dialysis.	Creatinine	270-280	serpin family E member 1	Homo sapiens	61-66
1375766-6	1992	The postischemic fall in creatinine clearance (CCr), filtration fraction (FF) and renal blood flow (RBF) was prevented by infusion of ANF (CCr: group 1, 0.16 +/- 0.05 vs. group 2, 1.01 +/- 0.25 ml/min x kgBW; FF: group 1, 4.0 +/- 1.6 vs group 2, 14.1 +/- 4.1%; RBF: group 1, 6.0 +/- 1.2 vs. group 2, 9.2 +/- 1.6 ml/min x kgBW); however, the effects were limited to the time of infusion and the postischemic increase in urinary excretion of the proximal tubular enzyme N-acetyl-beta-D-glucosaminidase (NAG; group 1, 317.7 +/- 163.6 vs. group 2, 672.4 +/- 245.7 microU/min x kgBW) was not improved by ANF.	Creatinine	25-35	natriuretic peptide A	Canis lupus familiaris	134-137
1797103-5	1991	The relation to creatinine excretion was markedly close for the lysosomal enzymes beta-N-acetyl-D-glucosaminidase, arylsulphatase A and beta-galactosidase (r = 0.71-0.83), as well as for alkaline phosphatase, leucine arylamidase and gamma-glutamyltransferase.	Creatinine	16-26	galactosidase, beta 1	Rattus norvegicus	136-154
1776840-2	1991	The rIL-2 infusion caused a reversible fall in ures and a non-reversible rise in creatinine.	Creatinine	81-91	interleukin 2	Rattus norvegicus	4-9
1762326-5	1991	In 12 of the 20 patients, the beta 2m excretion expressed as mg per g creatinine (Cr), increased from normal (less than 0.30) to an abnormal beta 2m excretion rate.	Creatinine	70-80	beta-2-microglobulin	Homo sapiens	30-37
1762326-5	1991	In 12 of the 20 patients, the beta 2m excretion expressed as mg per g creatinine (Cr), increased from normal (less than 0.30) to an abnormal beta 2m excretion rate.	Creatinine	82-84	beta-2-microglobulin	Homo sapiens	30-37
1762326-6	1991	The increased beta 2m excretion per g Cr occurring immediately after DMG administration lead us to conclude that this effect occurs when the nephrotoxic agent is present in the kidney.	Creatinine	38-40	beta-2-microglobulin	Homo sapiens	14-21
1661723-6	1991	Urinary leukotriene E4 was significantly elevated after inhaled PAF (366.0 +/- 66.9 ng/mmol creatinine, P less than 0.01) compared with methacholine (41.6 +/- 13.3) and saline (33.6 +/- 4.6).	Creatinine	92-102	PCNA clamp associated factor	Homo sapiens	64-67
1661723-7	1991	The major urinary TxA2 metabolite 2,3-dinor TxB2 was elevated after inhaled PAF (41.3 +/- 7.1 ng/mmol creatinine, P less than 0.01) compared with methacholine (14.0 +/- 2.7) and saline (17.1 +/- 3.9).	Creatinine	102-112	PCNA clamp associated factor	Homo sapiens	76-79
1659508-4	1991	A significant positive correlation was found between s-TM and serum creatinine levels in SLE patients (r = 0.813, p less than 0.001).	Creatinine	68-78	thrombomodulin	Homo sapiens	55-57
2058613-2	1991	There was a consistent and significant increase in epidermal growth factor/creatinine values at the time of diagnosis of necrotizing enterocolitis compared with baseline values.	Creatinine	75-85	epidermal growth factor	Homo sapiens	51-74
2058613-5	1991	The increased epidermal growth factor/creatinine levels may be related to the absorption into the circulation of preexisting gastrointestinal tract epidermal growth factor through damaged tissue or to increased synthesis by the gastrointestinal tract in response to the injury caused by necrotizing enterocolitis.	Creatinine	38-48	epidermal growth factor	Homo sapiens	14-37
2058613-5	1991	The increased epidermal growth factor/creatinine levels may be related to the absorption into the circulation of preexisting gastrointestinal tract epidermal growth factor through damaged tissue or to increased synthesis by the gastrointestinal tract in response to the injury caused by necrotizing enterocolitis.	Creatinine	38-48	epidermal growth factor	Homo sapiens	148-171
2012758-5	1991	The increase in beta 2m was most marked in patients with elevated pretreatment levels of serum beta 2m and creatinine.	Creatinine	107-117	beta-2-microglobulin	Homo sapiens	16-23
1847095-4	1991	Also, a significant positive correlation was noted between the concentration of plasma TM and serum creatinine (r = 0.55, P less than 0.001).	Creatinine	100-110	thrombomodulin	Homo sapiens	87-89
1996485-3	1991	However, patients with markedly elevated serum creatinine levels (6.0 to 14.0 mg/dL [530-1240 mumol/L]) had a significantly greater average hemoglobin loss (-0.82 +/- 1.3 g/dL [-8 +/- 13 g/L], n = 11) than patients with normal serum creatinine levels (-0.12 +/- 0.88 g/dL [-1 +/- 9 g/L], n = 450) (p = 0.011).	Creatinine	47-57	l(1)9	Drosophila melanogaster	269-281
1878735-5	1991	The GM-CSF group had lower haemoglobin concentrations and platelets counts, and higher plasma urea creatinine and bilirubin, than the placebo group.	Creatinine	99-109	colony stimulating factor 2	Homo sapiens	4-10
1756527-3	1991	Moreover, both creatinine clearance (CrCl) and FENa result respectively correlated directly (r = +0.63) and indirectly (r = -0.46) with gestational age of twins.	Creatinine	15-25	CRCL	Homo sapiens	37-41
2082719-5	1990	Similarly, pregnant women had higher spot urine CRH IR - 54.6 +/- 15.5 pg/mumol creatinine (Cr) versus 5.0 +/- 0.5 pg/mumol Cr (separate t = 3.20, p = 0.0038, d.f.	Creatinine	80-90	corticotropin releasing hormone	Homo sapiens	48-51
2082719-5	1990	Similarly, pregnant women had higher spot urine CRH IR - 54.6 +/- 15.5 pg/mumol creatinine (Cr) versus 5.0 +/- 0.5 pg/mumol Cr (separate t = 3.20, p = 0.0038, d.f.	Creatinine	92-94	corticotropin releasing hormone	Homo sapiens	48-51
2082719-6	1990	= 24.0) - and 24-hour urine CRH IR - 13.7 +/- 1.2 pg/mumol Cr compared with 7.7 +/- 0.8 pg/mumol Cr (separate t = 4.28, p = 0.003, d.f.	Creatinine	59-61	corticotropin releasing hormone	Homo sapiens	28-31
2082719-8	1990	The difference between urinary excretion of CRH IR as estimated by 24-hour urine (13.7 +/- 1.2 pg/mumol Cr) and spot urine (54.6 +/- 15.5 pg/mumol Cr) indicated that CRH IR in 24-hour urine may be degraded during storage.	Creatinine	104-106	corticotropin releasing hormone	Homo sapiens	44-47
2150085-7	1990	In addition, ANF prevented radiocontrast-induced reductions in creatinine clearance in dogs with experimental CHF.	Creatinine	63-73	natriuretic peptide A	Canis lupus familiaris	13-16
1701609-3	1990	Urinary IGF-II was found at much higher concentrations than IGF-I (mean +/- SEM: 717 +/- 69 vs 110 +/- 5 ng/mmol creatinine).	Creatinine	113-123	insulin like growth factor 2	Homo sapiens	8-14
1701609-6	1990	The mean IGF binding protein-1 concentrations in these urine samples was 414 +/- 83 ng/mmol creatinine.	Creatinine	92-102	insulin like growth factor binding protein 1	Homo sapiens	9-30
2336970-4	1990	Urinary EGF levels of pregnant women reached their peak (24.6 +/- 6.7 ng/mg creatinine) at 19-22 gestational weeks; after that, they slightly decreased.	Creatinine	76-86	epidermal growth factor	Homo sapiens	8-11
2336970-9	1990	Furthermore, EGF concentrations in amniotic fluid have a significant correlation with the creatinine levels in amniotic fluid.	Creatinine	90-100	epidermal growth factor	Homo sapiens	13-16
2302769-4	1990	Specificity of SCC increased (91.1%) when we excluded patients in renal failure or with creatinine values greater than 133 mumol/L.	Creatinine	88-98	serpin family B member 3	Homo sapiens	15-18
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	80-90	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	8-13
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	92-94	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	8-13
34799437-5	2022	Results Urat1-Uox DKO mice had uricosuric effects and elevated levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) as renal injury markers, and decreased Cr clearance (CLCr) observed in a forced swimming test.	Creatinine	165-167	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	8-13
34962662-11	2022	SGLT2i also showed high certainty in reducing risk of hospitalization for heart failure (hHF), end stage renal disease (ESRD), acute kidney injury, doubling in serum creatinine and decline in eGFR.	Creatinine	166-176	solute carrier family 5 member 2	Homo sapiens	0-5
34858169-9	2021	Vancomycin CL was influenced by creatinine clearance (CRCL) and body weight of the patients; however, no covariate was significant for its effect on the volume of distribution.	Creatinine	32-42	CRCL	Homo sapiens	54-58
34858392-10	2021	Pearson and Spearman analyses revealed that serum resistin was positively correlated with CAP severity scores, white blood cells, urea nitrogen, creatinine, and inflammatory cytokines among CAP patients.	Creatinine	145-155	resistin	Homo sapiens	50-58
34297067-8	2021	Median CTX(mug/mmol creatinine) increased from 14 to 34 weeks" gestation in both groups (n = 372 total) (placebo (n = 188) 223.6 to 449.7; cholecalciferol (n = 184) 222.3 to 419.3; P = 0.03 for placebo vs cholecalciferol difference in CTX at 34 weeks" gestation).	Creatinine	20-30	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	7-10
34754053-3	2021	Based on reports that human epididymis four (HE4) / creatinine (CRE) ratios found in urine are elevated in ovarian cancers, we have developed a paper-based device that combines lateral flow technology and cell phone analysis to quantitatively measure HE4/CRE.	Creatinine	52-62	WAP four-disulfide core domain 2	Homo sapiens	251-254
34754053-3	2021	Based on reports that human epididymis four (HE4) / creatinine (CRE) ratios found in urine are elevated in ovarian cancers, we have developed a paper-based device that combines lateral flow technology and cell phone analysis to quantitatively measure HE4/CRE.	Creatinine	64-67	WAP four-disulfide core domain 2	Homo sapiens	45-48
34754053-3	2021	Based on reports that human epididymis four (HE4) / creatinine (CRE) ratios found in urine are elevated in ovarian cancers, we have developed a paper-based device that combines lateral flow technology and cell phone analysis to quantitatively measure HE4/CRE.	Creatinine	255-258	WAP four-disulfide core domain 2	Homo sapiens	45-48
34873933-1	2021	BACKGROUND: The modified creatinine index (mCI), as a surrogate marker of muscle mass, has been associated with poor outcomes in patients undergoing hemodialysis.	Creatinine	25-35	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	43-46
34873933-14	2021	A steeper slope (per 0.1 unit increase in the decrease rate) in modified creatinine index was associated with increased risk of all-cause mortality (HR, 1.04; 95% CI, 1.02-1.07; P=.011).	Creatinine	73-83	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	163-165
34873933-15	2021	In addition, an annual 1 mg/kg/day decrease in modified creatinine index level increased the hazard of all-cause mortality by 4% (HR, 1.04; 95% CI, 1.02-1.07; P=.001).	Creatinine	56-66	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	144-146
34988164-11	2021	On the other hand, the preoperative expression of ATF3 was negatively correlated with the preoperative creatinine level, but not affected by the patient"s age, weight, gender, preoperative cardiac function, preoperative blood routine examination and liver function.	Creatinine	103-113	activating transcription factor 3	Homo sapiens	50-54
34137456-5	2021	Based on 530 serum and 373 urine creatinine observations from 138 critically ill patients, a one compartment creatinine model with zero-order creatinine generation rate (CGR) and first-order creatinine clearance (CrCL) was evaluated.	Creatinine	191-201	CRCL	Homo sapiens	213-217
34137456-9	2021	In conclusion, a dynamic model of creatinine kinetics provides the means to estimate actual CrCL despite dynamic changes in kidney function, and it can easily be incorporated into population pharmacokinetic evaluations.	Creatinine	34-44	CRCL	Homo sapiens	92-96
34724064-4	2022	RESULTS: In Zeb2-cKO mice, the levels of plasma creatinine and blood urea nitrogen post-IRI were significantly lower than that in WT mice.	Creatinine	48-58	zinc finger E-box binding homeobox 2	Mus musculus	12-16
34702781-5	2021	Diabetic Sco2 KO/KI and Sco2 KI/KI hypomorphs exhibited a reduction in complex IV activity, but an improvement in albuminuria, serum creatinine, and histomorphometric evidence of early DKD as compared to db/db mice.	Creatinine	133-143	SCO2 cytochrome c oxidase assembly protein	Mus musculus	9-13
34702781-5	2021	Diabetic Sco2 KO/KI and Sco2 KI/KI hypomorphs exhibited a reduction in complex IV activity, but an improvement in albuminuria, serum creatinine, and histomorphometric evidence of early DKD as compared to db/db mice.	Creatinine	133-143	SCO2 cytochrome c oxidase assembly protein	Mus musculus	24-28
34702781-5	2021	Diabetic Sco2 KO/KI and Sco2 KI/KI hypomorphs exhibited a reduction in complex IV activity, but an improvement in albuminuria, serum creatinine, and histomorphometric evidence of early DKD as compared to db/db mice.	Creatinine	133-143	tumor necrosis factor receptor superfamily, member 8	Mus musculus	29-31
34453196-5	2022	Partial remission (PR) is defined as urine protein to creatinine ratio (UPC) of 0.2-2 (g/g) or decrease in UPC >= 50%, and complete remission (CR) is defined as UPC < 0.2 (g/g).	Creatinine	54-64	transmembrane protein 37	Homo sapiens	19-21
34180939-12	2021	Compared with sulfonylureas, SGLT2 inhibitors were associated with a reduced risk of death, regardless of cardiovascular disease status, in several categories of estimated glomerular filtration rate (including rates from >90 to <=30 mL/min/1.73 m2) and in participants with no albuminuria (albumin to creatinine ratio (ACR) <=30 mg/g), microalbuminuria (ACR >30 to <=300 mg/g), and macroalbuminuria (ACR >300 mg/g).	Creatinine	301-311	solute carrier family 5 member 2	Homo sapiens	29-34
34514204-6	2021	U-AQP2 per milligram of urinary creatinine (U-AQP2/Cr) decreased from 67.8 +- 50.6 to 20.7 +- 15.1 fmol/mg urinary creatinine after 1 month of tolvaptan treatment.	Creatinine	32-42	aquaporin 2	Homo sapiens	2-6
34514204-6	2021	U-AQP2 per milligram of urinary creatinine (U-AQP2/Cr) decreased from 67.8 +- 50.6 to 20.7 +- 15.1 fmol/mg urinary creatinine after 1 month of tolvaptan treatment.	Creatinine	32-42	aquaporin 2	Homo sapiens	46-50
34246297-9	2021	Five of those miRNAs (hsa-miR-126-3p, hsa-miR-142-3p, hsa-miR-146a-5p, hsa-miR-155-5p, and hsa-miR-222-3p) also had a positive correlation with serum creatinine and therefore a negative correlation with eGFR.	Creatinine	150-160	microRNA 146a	Homo sapiens	54-66
34161934-0	2021	Self-assembled Nano-Ag/Au@Au film composite SERS substrates show high uniformity and high enhancement factor for creatinine detection.	Creatinine	113-123	seryl-tRNA synthetase 1	Homo sapiens	44-48
34161934-3	2021	Here, we propose a high-performance Nano-Ag/Au@Au film composite SERS substrate for the rapid detection of creatinine in human serum.	Creatinine	107-117	seryl-tRNA synthetase 1	Homo sapiens	65-69
34161934-8	2021	Finally, we used the SERS substrate for the label-free detection of human serum creatinine.	Creatinine	80-90	seryl-tRNA synthetase 1	Homo sapiens	21-25
34161934-9	2021	The results showed that the LOD of this SERS substrate for serum creatinine was 5x10-6 M with a linear correlation coefficient of 0.96175.	Creatinine	65-75	seryl-tRNA synthetase 1	Homo sapiens	40-44
34242326-9	2021	On the other hand, resistin was found to be associated with white blood cell count, creatinine, ESR, and C-reactive protein.	Creatinine	84-94	resistin	Homo sapiens	19-27
35037044-9	2022	Plasma ANGPTL2 concentrations were positively associated with >80% and 100% higher risk of all-cause mortality and cancer mortality, respectively, after adjustment for gender, smoking, alcohol consumption, walking time, sleep duration, caloric intake, medical status, disease history, BMI, and triglyceride, creatinine, uric acid, and high sensitivity C-reactive protein levels.	Creatinine	308-318	angiopoietin like 2	Homo sapiens	7-14
35635326-2	2022	SGLT2 inhibition reduces urine albumin-creatinine ratio (UACR) and small studies suggest it also reduces MCP-1 and KIM-1.	Creatinine	39-49	solute carrier family 5 member 2	Homo sapiens	0-5
35623505-9	2022	Importantly, a significant reduction of MYDGF was found in glomeruli from patients with glomerular disease due to focal segmental glomerulosclerosis and diabetic kidney disease and the level of MYDGF was correlated with glomerular filtration rate, serum creatinine and podocyte loss.	Creatinine	254-264	myeloid derived growth factor	Homo sapiens	40-45
35623505-9	2022	Importantly, a significant reduction of MYDGF was found in glomeruli from patients with glomerular disease due to focal segmental glomerulosclerosis and diabetic kidney disease and the level of MYDGF was correlated with glomerular filtration rate, serum creatinine and podocyte loss.	Creatinine	254-264	myeloid derived growth factor	Homo sapiens	194-199
35595070-6	2022	LF administration conferred significant dose-dependent renoprotective impact against GLY-induced RM as evidenced by the decreased renal/somatic index and the significant improvement in renal functions as confirmed by the significant increase in creatinine clearance, decrease in serum creatinine and blood urea nitrogen, and improvement in albuminuria and proteinuria.	Creatinine	245-255	lactotransferrin	Rattus norvegicus	0-2
35595070-6	2022	LF administration conferred significant dose-dependent renoprotective impact against GLY-induced RM as evidenced by the decreased renal/somatic index and the significant improvement in renal functions as confirmed by the significant increase in creatinine clearance, decrease in serum creatinine and blood urea nitrogen, and improvement in albuminuria and proteinuria.	Creatinine	285-295	lactotransferrin	Rattus norvegicus	0-2
35524473-1	2022	AIMS/INTRODUCTION: We previously reported that sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment was associated with an improvement of the albumin-creatinine ratio (ACR) in Japanese patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).	Creatinine	157-167	solute carrier family 5 member 2	Homo sapiens	47-77
35239203-1	2022	BACKGROUND: Few real-world data on the relation between creatinine clearance (CrCl) and adverse clinical outcomes in Chinese emergency department (ED) patients with nonvalvular atrial fibrillation (AF).	Creatinine	56-66	CRCL	Homo sapiens	78-82
35312158-1	2022	The volume of contrast to creatinine clearance ratio (CV/CrCl) is a useful indicator of the risk of acute kidney injury (AKI) in patients undergoing percutaneous interventional procedures.	Creatinine	26-36	CRCL	Homo sapiens	57-61
35507854-9	2022	Dietary supplementation of GAA and RPM also increased the meat color a* and b* values at 24 h. Finally, Treatment II increased total protein, and serum concentrations of albumin and creatinine, but decreased serum urea nitrogen concentrations, indicating improved protein efficiency.	Creatinine	182-192	lysosomal alpha-glucosidase	Ovis aries	27-30
35509601-9	2022	Moreover, OPN levels were positively associated with systolic blood pressure (SBP), C-reactive protein, and albumin creatinine ratio (ACR).	Creatinine	116-126	secreted phosphoprotein 1	Homo sapiens	10-13
35468098-8	2022	RESULTS: ET-1 was positively correlated with HbA1c, creatinine levels, and duration of disease, and negatively correlated with AMS/ht2.	Creatinine	52-62	endothelin 1	Mus musculus	9-13
35451162-10	2022	Various factors affecting HMN (rise in creatinine to 1.5 times baseline) were recorded: age, sex, type of ALL, risk group of ALL, first dose of MTX, dose of MTX, undernourishment, serum protein, and albumin along with C-reactive protein and MTX36 levels.	Creatinine	39-49	metaxin 1	Homo sapiens	144-147
35440501-1	2022	Background: SGLT2 inhibitors and MRAs reduce the urinary albumin-to-creatinine ratio (UACR) and confer kidney and cardiovascular protection in patients with chronic kidney disease (CKD).	Creatinine	68-78	solute carrier family 5 member 2	Homo sapiens	12-17
35464092-13	2022	Finally, CCL2, FOS, JUN were manifested a meaningful association with proteinuria, glomerular filtration rate (GFR), and serum creatinine level.	Creatinine	127-137	C-C motif chemokine ligand 2	Homo sapiens	9-13
35363774-8	2022	Moreover, CDH2 and MCP-1 mRNAs inversely correlated with creatinine (r = -0.370 and r = -0.361, p<0.001) and Alb/Cr ratio (r = -0.355 and r = -0.297, p<0.001).	Creatinine	57-67	C-C motif chemokine ligand 2	Homo sapiens	19-24
35152003-5	2022	Conditional knockout of Tipe1 in RTECs significantly decreased the urine protein creatinine ratio, renal tubular damage, epithelial-mesenchymal transition, and interstitial fibrosis in STZ-induced mice.	Creatinine	81-91	tumor necrosis factor, alpha-induced protein 8-like 1	Mus musculus	24-29
35220220-9	2022	There was a correlation between H19 expression and creatinine (r=0.408; p=0.003).	Creatinine	51-61	H19 imprinted maternally expressed transcript	Homo sapiens	32-35
35059462-7	2022	Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels.	Creatinine	324-334	proprotein convertase subtilisin/kexin type 1	Homo sapiens	154-157
35059462-7	2022	Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels.	Creatinine	324-334	proprotein convertase subtilisin/kexin type 1	Homo sapiens	230-233
2478007-2	1989	In healthy volunteers, urinary NAG, alpha 1MG and beta 2MG levels were 3.5 +/- 1.4 (mean +/- SD) U/g creatinine, 2.5 +/- 2.0 mg/l and 88 +/- 75 micrograms/l, respectively.	Creatinine	101-111	beta-2-microglobulin	Homo sapiens	50-58
2595459-3	1989	In patients with chronic renal failure the serum myoglobin level correlated with serum creatinine and creatinine clearance as a measure of the glomerular filtration rate, indicating a major role of kidney in the metabolism of this low-molecular weight protein.	Creatinine	87-97	myoglobin	Homo sapiens	49-58
2595459-3	1989	In patients with chronic renal failure the serum myoglobin level correlated with serum creatinine and creatinine clearance as a measure of the glomerular filtration rate, indicating a major role of kidney in the metabolism of this low-molecular weight protein.	Creatinine	102-112	myoglobin	Homo sapiens	49-58
3186090-2	1988	The purpose of this study was to evaluate the relationship between plasma antithrombin III activity and both clotting parameters (platelet count and fibrinopeptide A) and renal parameters (serum creatinine and uric acid concentration).	Creatinine	195-205	serpin family C member 1	Homo sapiens	74-90
2462388-2	1988	Creatinine clearances (CrCl) ranged from zero to 121 ml/min.	Creatinine	0-10	CRCL	Homo sapiens	23-27
3257216-3	1988	Normal menstruating women had higher urinary EGF concentrations [mean +/- SE, 37.2 +/- 6.0 micrograms/g creatinine (4.23 +/- 0.68 ng/mumol)] than women with tubal sterilization [32.7 +/- 4.0 (3.71 +/- 0.45)] or women taking a low dose oral contraceptive [19.5 +/- 6.0 (2.21 +/- 0.68)], but the differences were not significant (P greater than 0.05).	Creatinine	104-114	epidermal growth factor	Homo sapiens	45-48
3140103-3	1988	In both groups, plasma beta 2M was negatively correlated with residual creatinine clearance, the influence of the latter being much greater in haemodialysis, as demonstrated by comparison of the regression lines.	Creatinine	71-81	beta-2-microglobulin	Homo sapiens	23-30
2451306-9	1987	PK and alpha 2-M correlated positively with each other and albumin and negatively with creatinine, bilirubin and CyA (2 p less than 0.01).	Creatinine	87-97	alpha-2-macroglobulin	Homo sapiens	7-16
3328500-2	1987	The value of serum beta 2-MG demonstrated the highest correlation coefficient (r = -0.927) in relation to creatinine clearance.	Creatinine	106-116	beta-2-microglobulin	Homo sapiens	19-28
3301163-3	1987	Elevation of plasma D-amino acid level was observed in a group of patients with renal disease (3.6-52.6 nmol/ml), in proportion to the serum level of creatinine (n = 50, r = 0.726, P less than 0.001), beta 2-microglobulin (n = 34, r = 0.551, P less than 0.005), and to glomerular filtration rate (n = 39, r = 0.556, P less than 0.001).	Creatinine	150-160	beta-2-microglobulin	Homo sapiens	201-221
3020748-2	1986	In patients with normal serum creatinine, 74% had elevated serum beta 2m levels.	Creatinine	30-40	beta-2-microglobulin	Homo sapiens	65-72
3740057-4	1986	Fractional excretion of myoglobin in the myoglobinuric patients increased as creatinine clearance decreased, although there was no correlation between filtered load and excretion rate of myoglobin.	Creatinine	77-87	myoglobin	Homo sapiens	24-33
3705194-8	1986	Of 59 patients followed for 2 months or more after discontinuing the DDP treatment, 3 (5.1%) presented creatinine values higher than 1.5 mg/dl.	Creatinine	103-113	translocase of inner mitochondrial membrane 8A	Homo sapiens	69-72
3705194-9	1986	The data deny that the incidence of nephrotoxicity is higher in patients receiving higher cumulative doses of DDP and confirm that increases in serum creatinine levels may occur some time after discontinuation of the drug.	Creatinine	150-160	translocase of inner mitochondrial membrane 8A	Homo sapiens	110-113
3534688-5	1986	The data clearly reveal that the beta-2-microglobulin/creatinine ratio shows a circadian rhythm in urinary excretion.	Creatinine	54-64	beta-2-microglobulin	Homo sapiens	33-53
3907676-4	1985	Serum beta 2-microglobulin concentrations correlated significantly with creatinine clearance (r = -0.819, P less than 0.001).	Creatinine	72-82	beta-2-microglobulin	Homo sapiens	6-26
3899115-6	1985	The values for normal males and females were 48.4 and 83.5 ng/mg creatinine, respectively, which shows that females excrete 1.7 times more hEGF than males.	Creatinine	65-75	epidermal growth factor	Homo sapiens	139-143
3157329-2	1985	Infusion of a synthetic atrial natriuretic factor into conscious dogs with caval constriction and ascites at doses of 175 and 350 ng X kg-1 X min-1 for 30 min each produced striking increases (P less than 0.05) in creatinine clearance, diuresis, and kaliuresis but failed to increase urinary sodium excretion.	Creatinine	214-224	natriuretic peptide A	Canis lupus familiaris	24-49
6381858-3	1984	The body clearance (ClB) of captopril decreased steadily with decreasing creatinine clearance (ClCr) from 5.2 ml/min/kg for mild renal failure patients to 1.6 ml/min/kg for hemodialysis patients during an interdialytic period.	Creatinine	73-83	citramalyl-CoA lyase	Homo sapiens	20-23
6355366-2	1983	Urinary excretion of neutral and acid alpha-glucosidase in reference subjects was found to be in the range 1.61 to 20.36 microkat/mol creatinine and 7.47 to 33.60 microkat/mol creatinine, respectively.	Creatinine	134-144	sucrase-isomaltase	Homo sapiens	38-55
6355366-2	1983	Urinary excretion of neutral and acid alpha-glucosidase in reference subjects was found to be in the range 1.61 to 20.36 microkat/mol creatinine and 7.47 to 33.60 microkat/mol creatinine, respectively.	Creatinine	176-186	sucrase-isomaltase	Homo sapiens	38-55
6225713-8	1983	PSP t/2 in rats treated with gentamicin or puromycin amino-nucleoside as well as that in rats given HgCl2 was increased in correlation with changes in common renal functional parameters such as serum urea nitrogen, serum creatinine, urinary protein and morphologic changes of the kidney.	Creatinine	221-231	persephin	Rattus norvegicus	0-3
7453568-4	1980	Clearance of secretin was less than 0.05% of creatinine clearance and nearly constant over the plasma range of 10-170 ng/ml.	Creatinine	45-55	SCT	Canis lupus familiaris	13-21
499308-6	1979	A linear relationship between K13 of cefoxitin and creatinine clearance was demonstrated.	Creatinine	51-61	keratin 13	Homo sapiens	30-33
83580-1	1978	Plasma beta2-microglobulin ratio were calculated taking into account serum creatinine levels and were found to be elevated in a variety of lymphoproliferative disorders.	Creatinine	75-85	beta-2-microglobulin	Homo sapiens	7-26
318106-5	1978	Twenty-four-hour urinary excretion of RIA-hEGF by normal adult males and females was 63.0 +/- 3.0 and 52.0 +/- 3.5 (mean +/- SE) micrograms/total vol, or 29.7 +/- 1.1 and 39.8 +/- 1.7 micrograms/g creatinine, respectively.	Creatinine	197-207	epidermal growth factor	Homo sapiens	42-46
34040351-4	2021	Results: A single-compartment model with a covariate creatinine clearance (CrCL) was chosen as the final model.	Creatinine	53-63	CRCL	Homo sapiens	75-79
33990175-1	2021	BACKGROUND: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) should be considered for patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) having estimated glomerular filtration rate (eGFR) >= 30 mL/min/1.73 m2 and urine albumin-to-creatinine ratio (UACR) > 30 mg/g.	Creatinine	249-259	solute carrier family 5 member 2	Homo sapiens	12-42
33273214-7	2021	Compared with baseline, the median urine beta2-microglobulin-to-creatinine ratio at week 48 decreased significantly from 241 to 134 mug/g (p<0.001).	Creatinine	64-74	beta-2-microglobulin	Homo sapiens	41-60
32989831-5	2021	Tucatinib also inhibited OCT2- and MATE1-mediated transport of creatinine, with IC50 values of 0.107 and 0.0855 microM, respectively.	Creatinine	63-73	solute carrier family 22 member 2	Homo sapiens	25-29
32989831-11	2021	These data demonstrate that tucatinib inhibits OCT2- and MATE1/2-K-mediated tubular secretion of creatinine, which may manifest as mild SCr elevations that are not indicative of renal impairment.	Creatinine	97-107	solute carrier family 22 member 2	Homo sapiens	47-51
33745222-6	2021	PTEN concentration was positively correlated with serum urea (Urea), creatinine (Crea), cystatin C (Cysc), 24 h urine total protein (24 h-UP) and negatively correlated with albumin (Alb) and estimated glomerular filtration rate (eGFR).	Creatinine	69-79	phosphatase and tensin homolog	Homo sapiens	0-4
33745222-6	2021	PTEN concentration was positively correlated with serum urea (Urea), creatinine (Crea), cystatin C (Cysc), 24 h urine total protein (24 h-UP) and negatively correlated with albumin (Alb) and estimated glomerular filtration rate (eGFR).	Creatinine	81-85	phosphatase and tensin homolog	Homo sapiens	0-4
33749466-3	2021	Following, correlations between research index and differences between groups were analyzed using SPSS.Results: Serum resistin levels statistically significantly negatively correlated with SB, DB and BMI, but statistically significantly positively correlated with serum creatinine (SCR) and serum albumin (ALB), even after adjustment for age and/or gender.	Creatinine	270-280	resistin	Homo sapiens	118-126
33737618-0	2021	Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.	Creatinine	77-87	solute carrier family 22 member 2	Homo sapiens	11-18
33737618-1	2021	The purpose of this study was to investigate the effects of SLC22A2 808G>T polymorphism and trough concentrations (C0) of bosutinib on serum creatinine in 28 patients taking bosutinib.	Creatinine	141-151	solute carrier family 22 member 2	Homo sapiens	60-67
33737618-5	2021	In multivariate analyses, the SLC22A2 808G/G genotype, patient age, bosutinib C0 and second-line or later bosutinib were independent factors influencing the change rate of creatinine.	Creatinine	172-182	solute carrier family 22 member 2	Homo sapiens	30-37
33737618-6	2021	Bosutinib elevated serum creatinine through organic cation transporter 2 (OCT2).	Creatinine	25-35	solute carrier family 22 member 2	Homo sapiens	44-72
33737618-6	2021	Bosutinib elevated serum creatinine through organic cation transporter 2 (OCT2).	Creatinine	25-35	solute carrier family 22 member 2	Homo sapiens	74-78
33737618-8	2021	Periodic measurement of serum creatinine after bosutinib therapy is necessary to avoid progression to severe renal dysfunction from simple elevation of creatinine mediated by OCT2 following bosutinib treatment.	Creatinine	30-40	solute carrier family 22 member 2	Homo sapiens	175-179
33737618-8	2021	Periodic measurement of serum creatinine after bosutinib therapy is necessary to avoid progression to severe renal dysfunction from simple elevation of creatinine mediated by OCT2 following bosutinib treatment.	Creatinine	152-162	solute carrier family 22 member 2	Homo sapiens	175-179
33651336-7	2022	Furthermore, at two weeks post-injection of EPO(+)-KMSCs or EPO(+)-EVs into CKD mice with renal anemia, we observed significant increases in hemoglobin levels (11.7 +- 0.2 and 11.5 +- 0.2 vs. 10.1 +- 0.2 g/dL, respectively) and significantly lower serum creatinine levels at eight weeks in comparison to mice receiving vehicle control (0.30 +- 0.00 and 0.23 +- 0.03 vs. 0.43 +- 0.06 mg/dL, respectively).	Creatinine	254-264	erythropoietin	Mus musculus	44-47
33651336-7	2022	Furthermore, at two weeks post-injection of EPO(+)-KMSCs or EPO(+)-EVs into CKD mice with renal anemia, we observed significant increases in hemoglobin levels (11.7 +- 0.2 and 11.5 +- 0.2 vs. 10.1 +- 0.2 g/dL, respectively) and significantly lower serum creatinine levels at eight weeks in comparison to mice receiving vehicle control (0.30 +- 0.00 and 0.23 +- 0.03 vs. 0.43 +- 0.06 mg/dL, respectively).	Creatinine	254-264	erythropoietin	Mus musculus	60-63
32643269-1	2021	AIMS/INTRODUCTION: Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary albumin-to-creatinine ratio (ACR) and negatively associated with the estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.	Creatinine	170-180	TNF receptor superfamily member 1A	Homo sapiens	99-104
33421273-12	2021	In novel multivariable regression models including medication, age, left ventricular ejection fraction, and discharge creatinine, cMyC remained an independent predictor of death and had no interactions with medical therapies at discharge.	Creatinine	118-128	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	130-134
33026316-6	2021	The influence of different covariates (age, sex, body weight, serum creatinine (SeCR), and creatinine clearance (CRCL)) was observed on ciprofloxacin clearance (CL) and volume of distribution (Vd) by stepwise covariate modeling (SCM).	Creatinine	91-101	CRCL	Homo sapiens	113-117
33341801-11	2021	The high endostatin expression group had significantly higher levels of serum creatinine and BUN and more severe tubular/interstitial damage.	Creatinine	78-88	collagen type XVIII alpha 1 chain	Homo sapiens	9-19
32703672-5	2020	EPO preconditioning significantly improved renal function and histologic morphology, indicated by reduced blood urea nitrogen (BUN) ([33.12 +- 1.88] vs [16.03 +- 0.91], P < .05) and serum creatinine (Scr) ([190.2 +- 20.23] vs [77.23 +- 5.82], P < .05) levels and histologic injury scores ([3.20 +- 0.78] vs [1.70 +- 0.67], P < .05).	Creatinine	188-198	erythropoietin	Rattus norvegicus	0-3
33223841-5	2020	Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P<0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P<0.001), and negatively with glomerular filtration rate (eGFR) (r=-0.159, P=0.022).	Creatinine	97-107	fibrillin 1	Homo sapiens	32-40
32852729-11	2020	Simply linear regression analysis indicated serum myonectin was negatively correlated body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, uric acid, and ACR, and positively correlated with glomerular filtration rate, insulin treatment.	Creatinine	186-196	erythroferrone	Homo sapiens	50-59
33275236-13	2020	In comparison with the model group, miR-34a inhibitor group had lowered serum creatinine level, urea nitrogen level, expressions of miR-34a, TNF-alpha and Bcl-2, and apoptotic rate (p<0.05), but raised levels of KLF4 and IL-10 (p<0.05), showing statistically significant differences.	Creatinine	78-88	microRNA 34a	Rattus norvegicus	36-43
32935470-6	2020	Furthermore, we found that aspartate aminotransferase, lactate dehydrogenase, creatine kinase, and creatinine levels were elevated in serum of LPS-induced CYP1A1-/- mice.	Creatinine	99-109	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	155-161
33144454-7	2020	Female and lower creatinine clearance (CCr) were identified as independent risk factors for delayed elimination of MTX.	Creatinine	17-27	metaxin 1	Homo sapiens	115-118
32766700-11	2020	No significant changes in estimated glomerular filtration rate or UPCR occurred, but RBP:creatinine and beta2M:creatinine improved following the switch to TAF.	Creatinine	111-121	alpha-2-macroglobulin	Homo sapiens	104-110
32713238-8	2020	Serum ELA showed significant negative correlations with serum creatinine (r = -0.529, p < .001), blood urea nitrogen (r = -0.575, p < .001), systolic blood pressure (r = -0.455, p < .001), and diastolic blood pressure (r = -0.450, p < .001), and significant positive correlations with hemoglobin (r = 0.523, p < .001) and eGFR (r = 0.728, p < .001).	Creatinine	62-72	apelin receptor early endogenous ligand	Homo sapiens	6-9
33295402-8	2020	However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004).	Creatinine	102-112	peptidyl arginine deiminase 4	Homo sapiens	9-13
33295402-11	2020	However, PAD4 concentrations were associated with creatinine and urea levels in these patients.	Creatinine	50-60	peptidyl arginine deiminase 4	Homo sapiens	9-13
33138036-9	2020	RESULTS: Evaluation of 1H-MRS data showed a decrease in 2-HG/total creatinine (tCr) ratios from the baseline to post-treatment scans in the mIDH1 murine model.	Creatinine	67-77	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	140-145
33133605-13	2020	Resistin correlated with increased creatinine (r s  = 0.18, p = 0.02).	Creatinine	35-45	resistin	Homo sapiens	0-8
33146353-11	2020	PTX-2 concentrations were correlated with serum albumin (r=0.30, p=0.016), and were negatively correlated with serum creatinine levels (rho=-0.42, p=0.01) and body mass index (r=-0.32, p=0.011).	Creatinine	117-127	amyloid P component, serum	Homo sapiens	0-5
33204323-10	2020	Spearman"s test demonstrated a remarkable positive correlation between urinary miR-452 and serum creatinine in sepsis patients (r=0.8269).	Creatinine	97-107	microRNA 452	Homo sapiens	79-86
33194177-8	2020	Besides, SPARC showed a significant positive correlation with DBP (+0.76), HDL (+0.54), Creatinine (+0.83), LVDd (+0.98), LVSD (+0.98), LAD (+0.98), LVPWd (+0.84), AODd (+0.81), HR (+0.72), Triglycerides (+0.83), LAD (+0.69) and AODd (+0.52) whereas a negative correlation with Cholesterol (-0.52) and LDL (-0.71) in T2D.	Creatinine	88-98	secreted protein acidic and cysteine rich	Homo sapiens	9-14
33081058-6	2020	Endoglin expression was also correlated with reduced eGFR (p = 0.001), increased creatinine (p < 0.01), increased systolic blood pressure (p < 0.05), hypertension (p < 0.05), and higher IFTA scores (p < 0.001).	Creatinine	81-91	endoglin	Homo sapiens	0-8
33066568-8	2020	Renal damage in Ru-1 treated mice was lower in comparison with oxaliplatin treated mice, as evaluated by serum levels of urea and creatinine and histological evaluation, but Ru-1 induced higher liver damage than oxaliplatin, evaluated by the serum levels of alanine aminotransferase.	Creatinine	130-140	Scm like with four mbt domains 1	Homo sapiens	16-20
32996919-7	2020	The concentration of renal function-related molecules, creatinine and blood urea nitrogen diminished in the ECM scaffold with MH NPs.	Creatinine	55-65	multimerin 1	Homo sapiens	108-111
32281000-6	2020	RESULTS: Univariate models showed significant associations between TNFR1 and TNFR2, respectively, and CRP, age and creatinine.	Creatinine	115-125	TNF receptor superfamily member 1A	Homo sapiens	67-72
32281000-8	2020	In longitudinal analyses, TNFR1 but not TNFR2 was associated with increased short-term mortality, HR adjusted for age, BMI and creatinine 1.43 (95% CI 1.07-1.91), but not in the model also adjusted for CRP, HR 1.29 (95% CI 0.94-1.77).	Creatinine	127-137	TNF receptor superfamily member 1A	Homo sapiens	26-31
32601155-10	2020	The mean (SD) creatinine clearance (CrCl) was 125 mL/min (93).	Creatinine	14-24	CRCL	Homo sapiens	36-40
32832561-5	2020	Pearson"s correlation analysis showed correlation of lncRNA MALAT1 levels with ACR, urine beta2-microglobulin (beta2-MG), urine alpha1-microglobulin (alpha1-MG), creatinine (Cr), and glycosylated hemoglobin (HbA1c), while negative with superoxide dismutase (SOD) (r = -0.388, P < 0.05).	Creatinine	162-172	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-66
32832561-5	2020	Pearson"s correlation analysis showed correlation of lncRNA MALAT1 levels with ACR, urine beta2-microglobulin (beta2-MG), urine alpha1-microglobulin (alpha1-MG), creatinine (Cr), and glycosylated hemoglobin (HbA1c), while negative with superoxide dismutase (SOD) (r = -0.388, P < 0.05).	Creatinine	174-176	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-66
32935805-8	2020	There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection.	Creatinine	71-81	hepcidin antimicrobial peptide	Homo sapiens	41-49
32702829-8	2020	The levels of OX40L were correlated with Glasgow Coma Scale score, serum creatinine and high-sensitive C-reactive protein.	Creatinine	73-83	TNF superfamily member 4	Homo sapiens	14-19
32774701-5	2020	The serum creatinine and renal weight ratio was increased with obvious lesions and upregulated STAT3 and p-mTOR level.	Creatinine	10-20	mechanistic target of rapamycin kinase	Mus musculus	107-111
32671476-5	2020	There are, however, safety issues with current fibrates (peroxisome proliferator-activated receptor alpha [PPARalpha] agonists), notably the propensity for elevation in serum creatinine, indicating the need for new approaches.	Creatinine	175-185	peroxisome proliferator activated receptor alpha	Homo sapiens	57-105
32671476-5	2020	There are, however, safety issues with current fibrates (peroxisome proliferator-activated receptor alpha [PPARalpha] agonists), notably the propensity for elevation in serum creatinine, indicating the need for new approaches.	Creatinine	175-185	peroxisome proliferator activated receptor alpha	Homo sapiens	107-116
32664896-11	2020	Moreover, both MPC1 and MPC2 levels were significantly correlated with serum creatinine, BUN and eGFR in patients with DN, whereas no analogous trend was observed in nondiabetic kidney disease.	Creatinine	77-87	mitochondrial pyruvate carrier 1	Homo sapiens	15-19
32664896-11	2020	Moreover, both MPC1 and MPC2 levels were significantly correlated with serum creatinine, BUN and eGFR in patients with DN, whereas no analogous trend was observed in nondiabetic kidney disease.	Creatinine	77-87	mitochondrial pyruvate carrier 2	Homo sapiens	24-28
32658933-6	2020	In addition, the administration of miR-223 over-expressed macrophages with IL-4 pre-conditioning, but not IL-4 stimulated control cells, attenuated sepsis severity in LPS injected mice as evaluated by serum creatinine, liver enzymes, lung histology and serum cytokines.	Creatinine	207-217	interleukin 4	Mus musculus	75-79
32857720-10	2020	Polymorphic site of CYP11B2 (rs1799998) gene is associated with SBP and DBP increase (p<0.05), reduced GFR preferably calculated by CKDEPI-cystatin C (F=10.79-14.45; p<0.001) and elevated aldosterone content (F=55.84; p<0.001), creatinine and cystatin-S as well (F=4.16-5.08; p<0.05) mainly in the TT-genotype female carriers (p<0.001).	Creatinine	228-238	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	20-27
32267075-7	2020	This body of work has shown that SGLT2 inhibitors reduce the risk of surrogate renal endpoints such as albuminuria and mitigate the risk of hard renal endpoints including doubling of serum creatinine and end-stage kidney disease in patients with T2D.	Creatinine	189-199	solute carrier family 5 member 2	Homo sapiens	33-38
31972209-6	2020	KEY FINDINGS: Vit D decreased significantly liver and kidney functions: serum ALT and AST activities (P < 0.0005); creatinine and urea (P < 0.0005) concentrations; liver and kidney histopathological scores.	Creatinine	115-125	vitrin	Rattus norvegicus	14-17
31205262-4	2020	Creatinine clearance (CrCl) overestimated I-iothalamate GFR (iGFR), estimated GFR (eGFR) underestimated iGFR, and their average [Avg (CrCl and eGFR)] essentially eliminated the GFR bias (median bias = +2.2, -5.4 and -1.0 ml/min/1.73m, respectively; p&lt;0.001).	Creatinine	0-10	CRCL	Homo sapiens	22-26
31077038-5	2020	OTB-NAC could be detected in 11 of the analyzed 18 urine samples and was quantified in 5 urine samples in the range between 0.023 and 0.176 ng mg-1 creatinine.	Creatinine	148-158	synuclein alpha	Homo sapiens	4-7
31629394-9	2020	MicroRNA126 was positively correlated with age, eGFR, microRNA192 while negatively correlated with blood sugar, HBA1c, urea, creatinine and ACR .	Creatinine	125-135	microRNA 126	Homo sapiens	0-11
30789800-7	2020	Creatinine, BUN and SOD and CAT were improved by both 100 and 500 mg/kg of Vit C in the renal (P<0.05-P<0.001) and by 100 mg/kg in the liver (P<0.05-P<0.001).	Creatinine	0-10	vitrin	Rattus norvegicus	75-78
32369818-1	2020	INTRODUCTION: Drug dosing in patients with acute kidney injury (AKI) is based on the Cockroft-Gault (CG) equation-derived estimated Creatinine clearance (CGeCrCl) for historical reasons due to the lack of a validated method for estimating glomerular filtration rate (GFR) when Cr is rapidly changing.	Creatinine	132-142	CRCL	Homo sapiens	154-161
31881940-10	2019	Circulating irisin was positively correlated with quantitative insulin sensitivity check index (QUICKI, r = 0.178, p = 0.045) and triglycerides (r = 0.149, p = 0.022); while irisin was negatively correlated with waist circumference (WC, r = - 0.185, p = 0.037), waist-to-hip ratio (WHR, r = - 0.176, p = 0.047), fasting insulin (r = - 0.2, p = 0.024), serum creatinine (r = - 0.243, p = 0.006), homeostasis model assessment for insulin resistance (HOMA-IR, r = - 0.189, p = 0.033).	Creatinine	358-368	fibronectin type III domain containing 5	Homo sapiens	12-18
31881940-14	2019	Moreover, serum irisin levels were inversely correlated with adverse metabolic parameters including WC, WHR, creatinine, HOMA-IR and fasting insulin, suggesting that irisin may play a role in obesity related insulin resistance.	Creatinine	109-119	fibronectin type III domain containing 5	Homo sapiens	16-22
31915448-6	2019	Siwu plus EPO treatment significantly increased the rat hemoglobin content (p &lt; 0.05) and reduced blood urea nitrogen (p &lt; 0.05) and serum creatinine (p &lt; 0.001).	Creatinine	145-155	erythropoietin	Rattus norvegicus	10-13
31801580-8	2019	Joint utilization of C1q and CysC achieved very good performance (AUC = 0.933) which approximated to the best one observed in the combinations of C1q, Urea, CysC, eGFRCreat, and Creat (AUC = 0.975).	Creatinine	167-172	complement C1q A chain	Homo sapiens	21-24
31627406-6	2019	Urinary albumin-to-creatinine ratio (ACR) was significantly reduced in recipients of DPP-4 inhibitors after 24 weeks (29.2 microg/mg creatinine vs. 14.9 microg/mg creatinine, P &lt; 0.001), whereas urinary ACR was not significantly changed by sulfonylureas (39.9 microg/mg creatinine vs. 43.2 microg/mg creatinine, P = 0.641).	Creatinine	19-29	dipeptidyl peptidase 4	Homo sapiens	85-90
31627406-6	2019	Urinary albumin-to-creatinine ratio (ACR) was significantly reduced in recipients of DPP-4 inhibitors after 24 weeks (29.2 microg/mg creatinine vs. 14.9 microg/mg creatinine, P &lt; 0.001), whereas urinary ACR was not significantly changed by sulfonylureas (39.9 microg/mg creatinine vs. 43.2 microg/mg creatinine, P = 0.641).	Creatinine	133-143	dipeptidyl peptidase 4	Homo sapiens	85-90
31627406-6	2019	Urinary albumin-to-creatinine ratio (ACR) was significantly reduced in recipients of DPP-4 inhibitors after 24 weeks (29.2 microg/mg creatinine vs. 14.9 microg/mg creatinine, P &lt; 0.001), whereas urinary ACR was not significantly changed by sulfonylureas (39.9 microg/mg creatinine vs. 43.2 microg/mg creatinine, P = 0.641).	Creatinine	133-143	dipeptidyl peptidase 4	Homo sapiens	85-90
31627406-6	2019	Urinary albumin-to-creatinine ratio (ACR) was significantly reduced in recipients of DPP-4 inhibitors after 24 weeks (29.2 microg/mg creatinine vs. 14.9 microg/mg creatinine, P &lt; 0.001), whereas urinary ACR was not significantly changed by sulfonylureas (39.9 microg/mg creatinine vs. 43.2 microg/mg creatinine, P = 0.641).	Creatinine	133-143	dipeptidyl peptidase 4	Homo sapiens	85-90
31627406-6	2019	Urinary albumin-to-creatinine ratio (ACR) was significantly reduced in recipients of DPP-4 inhibitors after 24 weeks (29.2 microg/mg creatinine vs. 14.9 microg/mg creatinine, P &lt; 0.001), whereas urinary ACR was not significantly changed by sulfonylureas (39.9 microg/mg creatinine vs. 43.2 microg/mg creatinine, P = 0.641).	Creatinine	133-143	dipeptidyl peptidase 4	Homo sapiens	85-90
31506491-6	2019	The serum alpha2-macroglobulin concentration was not associated with glycated hemoglobin or any other glycemic variable as evaluated from 48-h continuous glucose monitoring, but showed close correlation with left ventricular posterior wall thickness, carotid artery intima-media thickness, urinary albumin:creatinine ratio (ACR) and brachial-ankle pulse wave velocity (baPWV).	Creatinine	306-316	alpha-2-macroglobulin	Homo sapiens	10-30
31164243-1	2019	Recently, 2 dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and saxagliptin, adjusted dosing specification from creatinine clearance to glomerular filtration rate, more typically reported in routine laboratory tests.	Creatinine	119-129	dipeptidyl peptidase 4	Homo sapiens	12-34
31164243-1	2019	Recently, 2 dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and saxagliptin, adjusted dosing specification from creatinine clearance to glomerular filtration rate, more typically reported in routine laboratory tests.	Creatinine	119-129	dipeptidyl peptidase 4	Homo sapiens	36-41
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 22 member 2	Homo sapiens	157-185
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 22 member 2	Homo sapiens	187-191
31250339-6	2019	RESULTS: The kidney injury molecule-1-to-creatinine ratio (P = 0.035) and monocyte chemoattractant protein-1-to-creatinine ratio (P &lt; 0.001) increased significantly with the increase in kidney disease severity and varied according to different albuminuria statuses and estimated glomerular-filtration rates.	Creatinine	112-122	C-C motif chemokine ligand 2	Homo sapiens	74-108
31250339-7	2019	The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P &lt; 0.001).	Creatinine	42-52	C-C motif chemokine ligand 2	Homo sapiens	4-38
31696066-16	2019	Furthermore, leptin had a negative association with hematocrit, creatinine, and urea, TG, VLDL-C and a positive association with LDL-C and insulin among the participants of this study.	Creatinine	64-74	leptin	Homo sapiens	13-19
29172403-7	2019	In the multivariable analysis, lower hemoglobin levels, higher serum creatinine levels, and diabetes mellitus were significantly associated with a higher renalase levels.	Creatinine	69-79	renalase, FAD dependent amine oxidase	Homo sapiens	154-162
31348282-5	2019	Spearman correlation analysis showed that RPR were significantly correlated with age, sex, creatinine, hemoglobin, white blood cell, and advanced fibrosis (all with P &lt; .05).	Creatinine	91-101	exostosin like glycosyltransferase 3	Homo sapiens	42-45
31341885-11	2019	The only association with statistical significance was found between miR-21 and urine albumin-creatinine ratio (p =0.021).	Creatinine	94-104	microRNA 21	Homo sapiens	69-75
30937117-13	2019	We also found a significant decrease in urinary protein excretion after SGLT2 inhibitor therapy (urinary protein-to-creatinine ratio: (median), pre: 0.36, vs. post: 0.23 g/g creatinine, n = 35, P &lt; 0.01).	Creatinine	116-126	solute carrier family 5 member 2	Homo sapiens	72-77
30937117-13	2019	We also found a significant decrease in urinary protein excretion after SGLT2 inhibitor therapy (urinary protein-to-creatinine ratio: (median), pre: 0.36, vs. post: 0.23 g/g creatinine, n = 35, P &lt; 0.01).	Creatinine	174-184	solute carrier family 5 member 2	Homo sapiens	72-77
30632900-4	2019	Pulmonary arterial hypertension patients and unaffected BMPR2 mutation carriers had significantly elevated urinary albumin to creatinine ratios compared with healthy controls ( P &lt; 0.01; P = 0.04).	Creatinine	126-136	bone morphogenetic protein receptor type 2	Homo sapiens	56-61
30926764-2	2019	In this study, STZ-diabetic ETBR-/- mice was characterized by increased serum creatinine and urinary albumin, enhanced glomerulosclerosis, and upregulated ET-1 expression compared with STZ-diabetic WT mice.	Creatinine	78-88	endothelin receptor type B	Mus musculus	28-32
31015837-8	2019	The prevalence of clinical parameters such as bleeding on probing and number of sites with probing depth (PD) &gt;= 6 mm were greater in the beta 2-MG high group (&gt;=300 mug/g creatinine) than in the normal group (P=0.017 and 0.019, respectively).	Creatinine	178-188	beta-2-microglobulin	Homo sapiens	141-150
30876481-10	2019	RESULTS: ADSCs-Exo attenuated spontaneous diabetes by reducing levels of urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), and podocyte apoptosis in mice.	Creatinine	94-104	5'-3' exoribonuclease 1	Mus musculus	15-18
30414240-1	2019	The sodium glucose co-transporter-2 inhibitor dapagliflozin has been shown to decrease urinary albumin-to-creatinine ratio (UACR).	Creatinine	106-116	solute carrier family 5 member 2	Homo sapiens	4-35
30779214-8	2019	Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate.	Creatinine	150-160	fibroblast growth factor 23	Felis catus	24-30
30721819-6	2019	Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault formula.	Creatinine	0-10	CRCL	Homo sapiens	22-26
31454804-6	2019	Anti-beta2-GPI antibody-positive MN patients had significant improvement of serum creatinine compared to anti-beta2-GPI antibody-negative patients after 24 weeks of treatment (p = 0.006).	Creatinine	82-92	apolipoprotein H	Homo sapiens	5-14
30204470-6	2018	Hepcidin concentration was increased in patients with AAV, SLE and HD and correlated positively with C-reactive protein, serum ferritin and creatinine, and negatively with hemoglobin and serum transferrin.	Creatinine	140-150	hepcidin antimicrobial peptide	Homo sapiens	0-8
29659162-4	2018	Patients with C3d+ DSA had a higher creatinine (P = .03), more significant graft fibrosis (P = .035), and a faster rate of graft loss posttest compared to those with C3d- DSA (P = .05).	Creatinine	36-46	endogenous retrovirus group K member 13	Homo sapiens	14-17
29953588-6	2018	Compared with wild-type mice, NLRP3 knockout mice dramatically protected them from kidney injury, as indicated by the restoration of creatinine levels, lessened histopathological alterations, and the suppression of macrophages infiltration stained with F4/80.	Creatinine	133-143	NLR family, pyrin domain containing 3	Mus musculus	30-35
30503524-7	2018	Class II C3d-binding DSA was also significantly associated with graft failure on multivariate analysis, as were ABMR, chronic ABMR, and high serum creatinine.	Creatinine	147-157	endogenous retrovirus group K member 13	Homo sapiens	9-12
30524295-3	2018	Results show that SGK1 inhibitor EMD638683 significantly reversed renal dysfunction and cardiac dysfunction in echocardiography as indicated by decreased blood urine nitrogen and serum creatinine in AngII-infused mice.	Creatinine	185-195	serum/glucocorticoid regulated kinase 1	Mus musculus	18-22
30440136-10	2018	Expression of 8-oxo-Gsn had a good correlation with renal function[the Spearman "s correlation coefficient: serum 8-oxo-Gsn and serum creatinine was 0.629 (P&lt;0.001); urine/serum 8-oxo-Gsn and eGFR was 0.799 (P&lt;0.001); serum/urine 8-oxo-Gsn and serum/urine creatinine was 0.888 (P&lt;0.001)].	Creatinine	134-144	gelsolin	Homo sapiens	20-23
30440136-10	2018	Expression of 8-oxo-Gsn had a good correlation with renal function[the Spearman "s correlation coefficient: serum 8-oxo-Gsn and serum creatinine was 0.629 (P&lt;0.001); urine/serum 8-oxo-Gsn and eGFR was 0.799 (P&lt;0.001); serum/urine 8-oxo-Gsn and serum/urine creatinine was 0.888 (P&lt;0.001)].	Creatinine	262-272	gelsolin	Homo sapiens	20-23
30440136-12	2018	After multiple linear regression analysis, 8-oxo-Gsn was only associated with serum creatinine (beta=0.656, t=8.275, P&lt;0.001).	Creatinine	84-94	gelsolin	Homo sapiens	49-52
29497975-6	2018	Plasma concentrations of uPAR showed strong statistically significant positive correlations with serum creatinine or urea and strong negative correlation with estimated glomerular filtration rate (eGFR).	Creatinine	103-113	plasminogen activator, urokinase receptor	Homo sapiens	25-29
29958959-13	2018	In vivo, LEP treatment significantly reduced the effects of CCl4 intoxication on serum liver biomarkers (AST, ALT, LDH, and GGT) and the effect of cisplatin on serum renal biomarkers (urea, blood urea nitrogen, creatinine, and uric acid).	Creatinine	211-221	leptin	Mus musculus	9-12
29774463-12	2018	Patients with increased cIMT presented higher levels of urine microalbumin to creatinine ratio (p = 0.025).	Creatinine	78-88	CIMT	Homo sapiens	24-28
30197321-2	2018	Adenosine deaminase acting on RNA (ADAR) is a key protein for A-to-I editing, which converts the adenosine group of a double-stranded RNA to creatinine group by deaminating it, resulting in a change of nucleotide sequence.	Creatinine	141-151	adenosine deaminase RNA specific	Homo sapiens	0-33
30197321-2	2018	Adenosine deaminase acting on RNA (ADAR) is a key protein for A-to-I editing, which converts the adenosine group of a double-stranded RNA to creatinine group by deaminating it, resulting in a change of nucleotide sequence.	Creatinine	141-151	adenosine deaminase RNA specific	Homo sapiens	35-39
30271618-4	2018	Levels of B2MG were positively correlated with plasma creatinine and negatively correlated with glomerular filtration rate.	Creatinine	54-64	beta-2-microglobulin	Homo sapiens	10-14
30271618-5	2018	Plasma creatinine, systolic blood pressure and cholesterol were independently associated with B2MG values.	Creatinine	7-17	beta-2-microglobulin	Homo sapiens	94-98
30135658-7	2018	Pharmacological inhibition of FABP4 by a highly selective inhibitor BMS309403 significantly reduced serum creatinine level, proinflammatory cytokine mRNA expression of tumor necrosis factor-alpha, interleukin-6, and monocyte chemoattractant protein 1 as well as attenuated renal tubular damage in glycerol-injured kidneys.	Creatinine	106-116	fatty acid binding protein 4, adipocyte	Mus musculus	30-35
30087386-7	2018	Further, post-operative DPP4-activity was negatively correlated with the extent of post-operative organ injury as measured by SAPS II and SOFA scoring, circulating levels of creatinine and lactate, as well as patients" stay on the ICU.	Creatinine	174-184	dipeptidyl peptidase 4	Homo sapiens	24-28
29412698-6	2018	Chronic application of empagliflozin (~25 mg kg-1  day-1) in Oat3-/- mice was associated with lower urinary glucose-to-creatinine ratios despite maintaining slightly higher blood glucose levels than WT.	Creatinine	119-129	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	61-65
30049504-0	2018	Prescription of DPP-4 Inhibitors to Patients With Adult Type 2 Diabetes Mellitus and Creatinine Clearance &gt;50 mL/min: The UK Primary Care Experience.	Creatinine	85-95	dipeptidyl peptidase 4	Homo sapiens	16-21
30049504-2	2018	Adopting a cross-sectional study design and using data from the UK General Practice, this study showed that at least 10% of patients with T2DM and a creatinine clearance level &gt;50 mL/min initiating treatment with a DPP-4 inhibitor were prescribed a dose lower than specified in the Summary of Product Characteristics.	Creatinine	149-159	dipeptidyl peptidase 4	Homo sapiens	218-223
29694931-2	2018	This study assessed whether urinary potassium excretion is related to simultaneously calculated creatinine clearance (CrCl) and can predict AKI in the critically ill. MATERIALS AND METHODS: In this prospective cohort study, the correlation between 2-h urinary potassium excretion and simultaneously calculated CrCl of 61 critically ill patients was assessed by Pearson"s correlation coefficient, and their ability to predict AKI (&gt;=stage 1 KDIGO) in the subsequent 7 days was assessed by area under the receiver-operating-characteristic (AUROC) curve.	Creatinine	96-106	CRCL	Homo sapiens	118-122
29577913-4	2018	RESULTS: Urinary GGT values for healthy volunteers were 14 U/g creatinine for the lower reference limit and 79 U/g creatinine for the upper reference limit.	Creatinine	63-73	gamma-glutamyltransferase light chain family member 3	Homo sapiens	17-20
29577913-6	2018	CONCLUSIONS: Reference limits for urinary GGT in healthy subjects were 14 to 79 U/g creatinine, and it is recommended to measure urinary GGT in fresh specimens.	Creatinine	84-94	gamma-glutamyltransferase light chain family member 3	Homo sapiens	42-45
29915248-1	2018	Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1).	Creatinine	0-10	solute carrier family 22 member 2	Rattus norvegicus	68-96
29915248-1	2018	Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1).	Creatinine	0-10	solute carrier family 22 member 2	Rattus norvegicus	98-102
29915248-2	2018	We previously showed that the tyrosine kinase inhibitor (TKI) crizotinib inhibits OCT2-mediated transport of creatinine.	Creatinine	109-119	solute carrier family 22 member 2	Rattus norvegicus	82-86
29915248-9	2018	Further, all these TKIs except pazopanib inhibited [14C]creatinine uptake by OCT2-overexpressing cells.	Creatinine	56-66	solute carrier family 22 member 2	Rattus norvegicus	77-81
29689601-5	2018	Mechanistically, the two-electron-reduced enzyme cofactor FMN delivers a hydride to generate an enolate intermediate, which reacts with the internal electrophile.	Creatinine	73-80	formin 1	Homo sapiens	58-61
29949175-8	2018	RESULTS: Renal function indexes such as urinary protein, creatinine, blood urea nitrogen, and glomerular filtration rate (GFR) were significantly higher with SGLT-2 inhibitor treatment compared with the control group (p&lt;0.05).	Creatinine	57-67	solute carrier family 5 member 2	Homo sapiens	158-164
29588429-5	2018	Hyp metabolism accounted for 12.8, 32.9, and 14.8 mg oxalate/g creatinine in subjects with PH1, PH2, and PH3, respectively, compared with 1.6 mg oxalate/g creatinine in controls.	Creatinine	63-73	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	91-94
29559678-6	2018	Serum creatinine level was higher in Trpv4 KO mice 6 and 24 hours after ischaemia compared to WT mice.	Creatinine	6-16	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	37-42
29277064-9	2018	In the validation set, the concentration of serum CC16 in the PM2.5 exposed group was 22.42% lower than that of the controls and an IQR (1.24mumol/mol creatinine) increase in urinary 1-OHP concentration was associated with a 12.24% decrease in serum CC16 levels in the DEE cohort.	Creatinine	151-161	secretoglobin family 1A member 1	Homo sapiens	50-54
28786769-10	2018	Plasma ADAMTS-13 activity was negatively correlated with the level of serum creatinine and proteinuria ( r = -0.354, p &lt; 0.001; r = -0.200, p = 0.011, respectively).	Creatinine	76-86	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	7-16
29126144-6	2018	Further, using only the urinary Kim-1 response to gentamicin (a nephrotoxicant with a distinctly different injury time course than cisplatin), the model detected and predicted mild to moderate PT injury, as confirmed with histopathology, even when serum creatinine was unchanged.	Creatinine	254-264	hepatitis A virus cellular receptor 1	Rattus norvegicus	32-37
29101068-5	2018	The results showed that the rs1862513 and rs34861192 of RETN gene were functional and negatively correlated with the levels of serum creatinine and cholesterol, respectively.	Creatinine	133-143	resistin	Homo sapiens	56-60
28834212-7	2018	As body-weight and creatinine clearance (CrCL) increased, the proportion of patients with a subtherapeutic level increased.	Creatinine	19-29	CRCL	Homo sapiens	41-45
29175119-7	2018	Spearman correlation analysis shows a positive correlation of plasma Hsp27 with serum creatinine (p=0.053, r-value 0.083).	Creatinine	86-96	heat shock protein family B (small) member 1	Homo sapiens	69-74
28770471-6	2018	Activity of ecto5"-nucleotidase increased from 0.032 +- 0.006 to 0.049 +- 0.014 nmol/mg tissue/min in kidney cortex of mice administered high-dose decaffeinated coffee (HDC) together with increase in cortex adenosine concentration and decrease in plasma creatinine concentration.	Creatinine	254-264	5' nucleotidase, ecto	Mus musculus	12-31
27778420-4	2018	Urine samples were collected on admission and 6 h after CA/PCI and tested for urinary renalase using ELISA method, which was expressed as renalase-to-creatinine ratio.	Creatinine	150-160	renalase, FAD dependent amine oxidase	Homo sapiens	86-94
27778420-7	2018	In comparison to baseline values, urinary renalase-to-creatinine ratio significantly decreased 6 h following CA/PCI, (2843.6 vs.1540.7 ng/mg, P &lt; 0.0001).	Creatinine	54-64	renalase, FAD dependent amine oxidase	Homo sapiens	42-50
28799920-11	2018	RPV/FTC/TDF showed a safer lipid profile and a greater increase in creatinine.	Creatinine	67-77	sex determining region Y	Homo sapiens	8-11
20301460-8	1993	DIAGNOSIS/TESTING: The diagnosis of PH1 is suspected in an individual with an elevated oxalate to creatinine ratio in urine and an elevated plasma oxalate concentration.	Creatinine	98-108	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	36-39
29163391-9	2017	Furthermore, the urea nitrogen and serum creatinine levels significantly increased in the contaminated tea-drinking mice.	Creatinine	41-51	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	103-106
28821425-3	2017	All eukaryotes including humans complete this well-understood transformation with thymidylate synthase utilizing 6R-N5-N10-methylene-5,6,7,8-tetrahydrofolate as both a source of methylene and a reducing hydride.	Creatinine	203-210	thymidylate synthetase	Homo sapiens	82-102
28784820-7	2017	Cisplatin-induced kidney damage was revealed by a significant rise in the plasma creatinine levels accompanied by significant morphologic changes in tubules, T cell Ig and mucin domain-containing protein-1, ionized calcium-binding adapter molecule 1, as well as a marked increase in the number of apoptotic cells localized in tubules.	Creatinine	81-91	allograft inflammatory factor 1	Rattus norvegicus	158-249
28794294-6	2017	Expression level of the miR-21 in plasma was correlated with creatinine (r = -0.432, P = .03) and estimated glomerular filtration rate (r = 0.423, P = .031).	Creatinine	61-71	microRNA 21	Homo sapiens	24-30
28600485-7	2017	RESULTS By silencing the TRB3 gene with siRNA, diabetic-induced nephropathy symptoms were alleviated, such as increased serum creatinine level and urinary albumin secretion.	Creatinine	126-136	tribbles pseudokinase 3	Rattus norvegicus	25-29
28736565-5	2017	Higher urinary osteopontin, but not plasma osteopontin, was associated with incident chronic kidney disease in multivariable models adjusted for age, cardiovascular risk factors, baseline glomerular filtration rate, urinary albumin/creatinine ratio, and the inflammatory markers interleukin 6 and high-sensitivity C-reactive protein (odds ratio for 1 standard deviation [SD] of urinary osteopontin, 1.42, 95% CI 1.00-2.02, p = 0.048).	Creatinine	232-242	secreted phosphoprotein 1	Homo sapiens	15-26
27165046-2	2017	The objective of this analysis was to evaluate the effect of renal function as determined by creatinine clearance (CrCL) on the pharmacokinetics of the DAAs, ritonavir, and ribavirin in HCV genotype 1-infected patients with or without cirrhosis.	Creatinine	93-103	CRCL	Homo sapiens	115-119
28179401-8	2017	Negative correlation was detected between serum soluble CD200 levels and serum creatinine levels (r=-0.761, p&lt;0.001), and C reactive protein levels (r=-0.364, p=0.015).	Creatinine	79-89	CD200 molecule	Homo sapiens	56-61
28219627-5	2017	Our data demonstrated ATIII significantly attenuated the elevation of serum creatinine, blood urea nitrogen, and renal histological injury.	Creatinine	76-86	serpin family C member 1	Homo sapiens	22-27
27650483-7	2017	The urine albumin-to-creatinine ratio genome-wide association scan identified associations with the HBB variant among all participants, with the strongest association in the Caribbean background group (P=3.1x10-10 versus P=9.3x10-3 for the Mainland background group).	Creatinine	21-31	hemoglobin subunit beta	Homo sapiens	100-103
28140480-9	2017	There was a significant positive correlation between serum creatinine concentration (CRT) and 2 of the APPs (SAA and hepcidin; P &lt; .05).	Creatinine	59-69	hepcidin antimicrobial peptide	Homo sapiens	117-125
28222023-7	2017	In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p&lt;0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021).	Creatinine	181-191	fibronectin type III domain containing 5	Homo sapiens	15-21
28523190-14	2017	In treated patients, urinary uPAR+ podocytes correlated with urinary protein : creatinine ratio (rho = 0.5; p = 0.02).	Creatinine	79-89	plasminogen activator, urokinase receptor	Homo sapiens	29-33
27769837-1	2016	Renalase catalyzes the oxidation of isomers of beta-NAD(P)H that carry the hydride in the 2 or 6 positions of the nicotinamide base to form beta-NAD(P)+.	Creatinine	75-82	renalase, FAD dependent amine oxidase	Homo sapiens	0-8
27835680-14	2016	SGLT2-i increased the risk of urinary and genital tract infections and increased serum creatinine, and exerted beneficial effects on bodyweight, blood pressure, lipids and alanine aminotransferase (moderate to low quality evidence).	Creatinine	87-97	solute carrier family 5 member 2	Homo sapiens	0-5
27829460-2	2016	Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease Study (MDRD4), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.	Creatinine	87-97	CRCL	Homo sapiens	109-113
27561093-5	2016	Our second aim was to find an association between MMPs, TIMP and creatinine.	Creatinine	65-75	matrix metallopeptidase 7	Homo sapiens	50-54
27561093-15	2016	MMP-7 and TIMP-1 correlated weakly with creatinine (Rho = 0.221 and 0.243).	Creatinine	40-50	matrix metallopeptidase 7	Homo sapiens	0-5
27189318-5	2016	RESULTS: Baseline and 24-month levels of monocyte chemotactic protein-1-to-creatinine ratio levels were higher for cases versus controls.	Creatinine	75-85	C-C motif chemokine ligand 2	Homo sapiens	41-71
27189318-6	2016	The highest quartile of baseline monocyte chemotactic protein-1-to-creatinine ratio had fivefold greater odds, and each log increment had 2.27-fold higher odds for outcome (odds ratio, 5.27; 95% confidence interval, 2.19 to 12.71 and odds ratio, 2.27; 95% confidence interval, 1.44 to 3.58, respectively).	Creatinine	67-77	C-C motif chemokine ligand 2	Homo sapiens	33-63
27121915-4	2016	Pearson"s relevant analysis showed that the levels of GST and spKt/V, IL-2, IL-6, IL-8, and TNF-a have a positive correlation (P &lt; 0.05), and they have no correlation with levels of creatinine, hs-CRP, TSAT, and PHT (P &gt; 0.05).	Creatinine	185-195	glutathione S-transferase kappa 1	Homo sapiens	54-57
27569927-8	2016	Compared with free DSA/NDSA, the MFI values of C1q-binding DSA/NDSA are more closely correlated with serum creatinine levels and reflect the effect of anti-antibody-mediated rejection treatment more sensitively.	Creatinine	107-117	complement C1q A chain	Homo sapiens	47-50
27496436-8	2016	Before transplantation, serum hepcidin was related to creatinine.	Creatinine	54-64	hepcidin antimicrobial peptide	Homo sapiens	30-38
27496485-10	2016	Creatinine was correlated with age (r = 0.36; P &lt; .01), diastolic blood pressure (r = 0.26; P &lt; .05), time after heart transplantation (r = 0.24; P &lt; .05), and renalase (r = 0.69; P &lt; .01).	Creatinine	0-10	renalase, FAD dependent amine oxidase	Homo sapiens	169-177
27224288-12	2016	), as an HSP70 inhibitor, reversed the beneficial effects of 17-DMAG on survival rate, plasma levels of ALT, CPK, creatinine, IL-6, and NO metabolites, iNOS induction, and caspase-3 activation in LPS-treated rats.	Creatinine	114-124	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	9-14
27067552-4	2016	The objective of this study was to determine whether the decline in creatinine clearance (CrCL) associated with TDF use is reversible once TDF is discontinued in a non-white patient population.	Creatinine	68-78	CRCL	Homo sapiens	90-94
27100576-1	2016	OBJECTIVES: To determine the risk to older adults of lung injury associated with treatment of cystitis using nitrofurantoin and the risk of treatment failure in the presence of diminished creatinine clearance (CrCl).	Creatinine	188-198	CRCL	Homo sapiens	210-214
27363050-12	2016	NAC showed improvement especially for MDA peroxidation marker and creatinine for kidney disorder.	Creatinine	66-76	synuclein alpha	Homo sapiens	0-3
26755510-4	2016	METHODS: Pretreatment renal function was defined as creatinine clearance (CrCl) using the Cockcroft-Gault equation.	Creatinine	52-62	CRCL	Homo sapiens	74-78
26997383-8	2016	Doubling of serum creatinine was observed in 25% of patients with C1q-positive and 24.2% of patients with C1q-negative deposits.	Creatinine	18-28	complement C1q A chain	Homo sapiens	66-69
26997383-8	2016	Doubling of serum creatinine was observed in 25% of patients with C1q-positive and 24.2% of patients with C1q-negative deposits.	Creatinine	18-28	complement C1q A chain	Homo sapiens	106-109
26232286-2	2016	In this study we compared the classification assessed from CrCl (creatinine clearance 24h urine collection) and e-GFR calculated with CKD-EPI or MDRD formulas.	Creatinine	65-75	CRCL	Homo sapiens	59-63
26466550-8	2016	Plasma resistin correlated positively with creatinine (r = 0.456, P &lt; 0.001) and resistin mRNA (r = 0.298, P = 0.014) but negatively with body mass index (r = -0.254, P = 0.034) and total cholesterol (r = -0.286, P = 0.021).	Creatinine	43-53	resistin	Homo sapiens	7-15
26821720-5	2016	The observed positive effects of these agents on measures such as glucose control, estimated glomerular filtration rate, albumin-to-creatinine ratio, blood pressure, and body weight in patients both with and without impaired renal function suggest that SGLT2 inhibitors represent an important extension to the diabetes treatment armamentarium.	Creatinine	132-142	solute carrier family 5 member 2	Homo sapiens	253-258
26539647-10	2016	In HD patients, serum hepcidin levels were associated with ferritin (r = 0.55, p &lt; 0.01) and creatinine (r = 0.27, p = 0.03).	Creatinine	96-106	hepcidin antimicrobial peptide	Homo sapiens	22-30
26627016-10	2016	Inflammation related hepcidin and NGAL weakly correlated with creatinine clearance.	Creatinine	62-72	hepcidin antimicrobial peptide	Homo sapiens	21-29
26142824-8	2015	Significant positive correlations were found between EMAP II levels and body mass index, fasting blood glucose, HbA1c, serum creatinine, triglycerides, total cholesterol, urinary albumin creatinine ratio (UACR) and hs-CRP (p&lt;0.05).	Creatinine	125-135	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	53-60
26142824-8	2015	Significant positive correlations were found between EMAP II levels and body mass index, fasting blood glucose, HbA1c, serum creatinine, triglycerides, total cholesterol, urinary albumin creatinine ratio (UACR) and hs-CRP (p&lt;0.05).	Creatinine	187-197	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	53-60
26508377-8	2015	Dramatic elevations of serum myoglobin (34,020 mug/L) and creatine kinase (219 mukat/L) were accompanied by rise in cardiac troponin I and creatinine.	Creatinine	139-149	myoglobin	Homo sapiens	29-38
26365492-1	2015	WHAT IS KNOWN AND OBJECTIVE: The dofetilide label recommends using actual body weight (ABW) to calculate the Cockcroft-Gault creatinine clearance (CrCl) for the determination of the initial dose; however, few studies have attempted to evaluate this dosing recommendation in overweight and obese patients.	Creatinine	125-135	CRCL	Homo sapiens	147-151
27249385-5	2015	We hereby describe the clinical covariates (age, sex and clearance of the creatinine) that influence MTX pharmacokinetic for predicting optimal dose to reduce MTX toxicity.	Creatinine	74-84	metaxin 1	Homo sapiens	101-104
27249385-5	2015	We hereby describe the clinical covariates (age, sex and clearance of the creatinine) that influence MTX pharmacokinetic for predicting optimal dose to reduce MTX toxicity.	Creatinine	74-84	metaxin 1	Homo sapiens	159-162
26866008-11	2015	Treatment with EPO or IPC decreased urea, creatinine, and renal MDA levels and increased SOD activity and GSH contents in the kidney.	Creatinine	42-52	erythropoietin	Rattus norvegicus	15-18
26403212-10	2015	CONCLUSIONS AND CLINICAL IMPORTANCE: Plasma FGF-23 concentration is a novel prognostic indicator in cats with CKD, independent of other factors including plasma creatinine and phosphate concentrations.	Creatinine	161-171	fibroblast growth factor 23	Felis catus	44-50
26999863-7	2015	To specify diagnosis of chronic dysfunction of renal allo-transplant the most useful (ratio of likelihood of positive result 10 and 11 correspondingly) are tests of beta-2- microglobulin in serum (more than 8.55 mkg/ml) and N-acetyl-beta-D-glucosaminidase/creatinine in urine (more than 34 nmol/(sl)/ mmol/l).	Creatinine	256-266	beta-2-microglobulin	Homo sapiens	165-186
26449648-8	2015	The in vivo ATP5b-siRNA delivery significantly enhanced renal fibrosis and serum creatinine in db/db mice with ATP5b down-regulation.	Creatinine	81-91	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	Mus musculus	12-17
26397985-8	2015	In correlation analyses, ANGPTL2 level was positively correlated to creatinine, fasting glucose, triglyceride, hsCRP, TNF-alpha, NT-proBNP and A-FABP levels, and negatively correlated with HDL-C and left ventricular ejection fraction.	Creatinine	68-78	angiopoietin like 2	Homo sapiens	25-32
25904701-8	2015	Multiple logistic regression and receiver-operating characteristics analysis further showed that urine VIM mRNA is the best predictive parameter of renal fibrosis compared with estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen.	Creatinine	221-231	vimentin	Homo sapiens	103-106
26183619-8	2015	However, systemic anti-miR-21 had substantial off-target effects, lowering miR-21 expression in liver, heart, lung, and kidney with concomitant increase in serum creatinine levels.	Creatinine	162-172	microRNA 21	Homo sapiens	23-29
26301416-4	2015	Creatinine clearance (CrCl) was assessed at base line and six-monthly, with renal dysfunction defined as CrCl &lt; 50 ml/min/1.73 m2.	Creatinine	0-10	CRCL	Homo sapiens	22-26
25593049-11	2015	Periostin was also correlated with worsening renal outcomes including serum creatinine, blood urea nitrogen and estimated glomerular filtration rate (eGFR).	Creatinine	76-86	periostin	Homo sapiens	0-9
25593049-12	2015	Subgroup analysis within patients with low activity index score or low chronicity index score found that there was a statistical difference in serum creatinine and eGFR between groups with low and high periostin staining scores.	Creatinine	149-159	periostin	Homo sapiens	202-211
26222851-3	2015	CT-1 positively correlates with basal glycaemia, SBP, DBP, PP, LVH, arterial damage (increased IMT, decreased ABI), and early renal damage (microalbuminuria, elevated albumin/creatinine ratio).	Creatinine	175-185	cardiotrophin 1	Homo sapiens	0-4
25510296-6	2015	CD147 protein expression in the renal tubules showed a negative correlation with estimated glomerular filtration rate (eGFR; r = -0.600, P = 0.000) and a positive correlation with serum creatinine (Scr; r = 0.322, P = 0.002) and tubulointerstitial lesions (r = 0.525, P = 0.000).	Creatinine	186-196	basigin (Ok blood group)	Homo sapiens	0-5
25143333-6	2015	RESULTS: Both glomerulosclerosis and urinary albumin-to-creatinine ratio were less in the ACE-inhibition arm at day 14.	Creatinine	56-66	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	90-93
25574207-11	2015	In the rat AOLT model, ulinastatin application was also shown to relieve renal pathological damage by reducing the serum cystatin C and creatinine levels.	Creatinine	136-146	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	23-34
25485598-8	2015	Six SNPs, present in OCRL (four SNPs) and ABCC2 (two SNPs), were significantly associated with increased serum creatinine levels in the cases, and this association remained significant after multiple test correction (P &lt; 2 x 10).	Creatinine	111-121	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	21-25
25563323-16	2015	Creatinine clearance and the number of methotrexate chemotherapy cycles before MTX infusion had a significant effect on the CL1, and body surface area had a significant effect on the CL2 and the V2 (P &lt; 0.	Creatinine	0-10	adhesion G protein-coupled receptor L1	Homo sapiens	124-127
25350977-4	2014	In a receiver operating characteristic curve analysis to differentiate between AKI and other renal diseases, the area under the curve for urinary TRX1 was 0.94 (95% confidence interval, 0.90-0.98), and the sensitivity and specificity were 0.88 and 0.88, respectively, at the optimal cutoff value of 43.0 mug/g creatinine.	Creatinine	310-320	thioredoxin	Homo sapiens	146-150
24819932-7	2014	In group 1, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r=0.46, p = 0.039 versus r=0.47, p=0.028, respectively), whereas triglyceride had a negative correlation (r= -0.35, p=0.047).	Creatinine	52-62	leptin	Homo sapiens	27-33
24813306-9	2014	Furthermore, relative changes of post-to-pre-surgical AFABP levels were independently associated with relative changes of post-to-pre-surgical creatinine concentrations.	Creatinine	143-153	fatty acid binding protein 4	Homo sapiens	54-59
24980763-9	2014	L-PAM causes also the violation of kidney function such as increase of urea and creatinine level; and rising of endogenic intoxication with elevation of middle mass molecules level.	Creatinine	80-90	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	2-5
24842819-2	2014	A 33-year-old man was admitted for an episode biopsy; he had a serum creatinine (S-Cr) level of 5.7 mg/dL 1 year following primary kidney transplantation.	Creatinine	69-79	l(1)L1	Drosophila melanogaster	103-107
24414608-10	2014	CONCLUSIONS: Urinary MCP-1/creatinine levels are elevated in the early stages of severe HSP nephritis and can be used as a biomarker for HSP nephritis.	Creatinine	27-37	C-C motif chemokine ligand 2	Homo sapiens	21-26
24851068-8	2014	The mean level of urinary beta2-MG was 1.92 +- 7.38 microg/mg creatinine.	Creatinine	62-72	beta-2-microglobulin	Homo sapiens	26-34
24851068-9	2014	There was a significant correlation between initial serum creatinine (iSCr), urine protein creatinine ratio (UPCR), and the level of beta2-MG (r = 0.744, r = 0.667, p &lt; 0.01).	Creatinine	58-68	beta-2-microglobulin	Homo sapiens	133-141
24851068-9	2014	There was a significant correlation between initial serum creatinine (iSCr), urine protein creatinine ratio (UPCR), and the level of beta2-MG (r = 0.744, r = 0.667, p &lt; 0.01).	Creatinine	91-101	beta-2-microglobulin	Homo sapiens	133-141
24742207-8	2014	The levels of serum renalase were positively correlated with systolic blood pressure (r=0.217, p=0.042) and serum creatinine (SCr) (r=0.295, p=0.007), and negatively correlated with eGFR (r=-0.222, p=0.044).	Creatinine	114-124	renalase, FAD dependent amine oxidase	Homo sapiens	20-28
24273190-6	2014	The benefit in terms of OS of the VMP group was quite similar among patients with different risk factors defined by sex, ISS, ECOG performance status, or serum creatinine but not among patients &gt;= 75 years.	Creatinine	160-170	neurensin 1	Homo sapiens	34-37
24283984-4	2014	RESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026).	Creatinine	52-62	enolase 1	Homo sapiens	70-90
24479423-9	2014	For each doubling increase of Mo (mug/g creatinine) during the third trimester of pregnancy, we observed a significant reduction on PDI (beta = -0.57 points; P = 0.03), and no effect on MDI (beta = 0.07 points; P = 0.66).	Creatinine	40-50	peptidyl arginine deiminase 1	Homo sapiens	132-135
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	185-189
24458916-2	2014	However, thioacetamide (MeC(S)NH2) as nucleophile and acetone/AlCl3 as hydride abstractor gave asymmetric 9-[MeC(NHiPr)S]-nido-7,8-C2B9H11 (2), whereas N,N-dimethylthioacetamide (MeC(S)NMe2) gave the expected symmetric 10-[MeC(NMe2)S]-nido-7,8-C2B9H11 (4).	Creatinine	71-78	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	227-231
23515495-1	2013	We aimed to find the relationship between serum transforming growth factor beta 1(TGF-beta(1)) and urinary monocyte chemoattractant protein-1 (MCP-1) throughout the course of diabetic nephropathy (DN) and to assess the relationship between both levels and other parameters of renal injury such as albumin/creatinine ratio and estimated glomerular filtration rate (eGFR).	Creatinine	305-315	C-C motif chemokine ligand 2	Homo sapiens	143-148
23553275-12	2013	On univariate analysis, age, WC, plaque formation, and D/P creatinine were positively correlated with CIMT, whereas residual renal function, albumin, ultrafiltration volume, and D/D0 glucose were negatively correlated.	Creatinine	59-69	CIMT	Homo sapiens	102-106
24346383-1	2013	OBJECTIVE: To evaluate the antidiabetic drug dosage differences between geriatric and nongeriatric diabetics with reference to duration of disease and creatinine clearance (Crcl).	Creatinine	151-161	CRCL	Homo sapiens	173-177
23219355-10	2013	RESULTS: There was an excellent correlation between urine (expressed as ng/mg of creatinine) and serum hepcidin levels expressed as ng/ml (r=0.853, p&lt;0.001).	Creatinine	81-91	hepcidin antimicrobial peptide	Homo sapiens	103-111
23833276-9	2013	NLRP3(-/-) mice with ischemic AKI had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls.	Creatinine	85-95	NLR family, pyrin domain containing 3	Mus musculus	0-5
23778650-6	2013	The area under the curve for the combination of PAI-1 mRNA, biopsy, and creatinine was 0.92 (95% CI, 0.80-1.0; P &lt; 0.001) by receiver operating characteristic curve analysis, and the area under the curve was 0.92 (95% CI, 0.80-1.0; P &lt; 0.001) for the combination of PAI-1 mRNA and creatinine.	Creatinine	287-297	serpin family E member 1	Homo sapiens	48-53
23778650-8	2013	CONCLUSION: Urinary cell level of PAI-1 mRNA, measured at the time of BKVN diagnosis, is an independent prognosticator of graft failure and a prediction model of serum creatinine and PAI-1 mRNA is as accurate as the model that includes the biopsy result.	Creatinine	168-178	serpin family E member 1	Homo sapiens	34-39
23866022-7	2013	In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction.	Creatinine	115-125	fatty acid binding protein 4	Homo sapiens	29-35
23753530-8	2013	Ucn2 cotherapy additionally increased urine potassium and creatinine excretion.	Creatinine	58-68	urocortin-2	Ovis aries	0-4
23876892-8	2013	RESULTS: Urine deoxypyridinoline/urine creatinine (DPD/Cr) ratio was significantly higher in SHR than in WKY.	Creatinine	39-49	dihydropyrimidine dehydrogenase	Rattus norvegicus	51-54
23763522-8	2013	Protonation reactions on complexes 13 and 14 with HCl yielded the hydride complex [Ir(kappa(2)-A2BPN)(CO)(Cl)(H)PPh3] (15) and the C-alkyl compound [ Ir{kappa(3)-(allyl)B(CH2 CHCH3)(CH2PPh2)(Pz)}(Cl)(CO)PMe3] (16), respectively.	Creatinine	66-73	protein phosphatase 4 catalytic subunit	Homo sapiens	112-116
24073552-7	2013	There was a statistically significant correlation between higher ADAMTS13 activities and higher platelets count (p = 0.002), blood urea nitrogen (p = 0.000), and creatinine level (p = 0.000).	Creatinine	162-172	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	65-73
23411430-9	2013	High-dose ifosfamide (odds ratio=6.19, 95% confidence interval=2.45; 15.67) was associated with increased urinary beta2-microglobulin creatinine ratio.	Creatinine	134-144	beta-2-microglobulin	Homo sapiens	114-133
23678231-7	2013	Urinary creatinine standardized uPAR (in pg mL mug-1 creatinine) changed significantly between groups, decreasing by about half following seaweed supplementation (placebo 1, 1.5 (95 % CI, 0.9-2.1) and seaweed, 0.9 (95 % CI, 0.6-1.1) while placebo 2 returned to pre-seaweed concentration (1.7 (95 % CI, 1.2-2.2); p = 0.01, ANOVA).	Creatinine	8-18	plasminogen activator, urokinase receptor	Homo sapiens	32-36
23302722-3	2013	Compared with wild-type mice, adiponectin-knockout mice were found to have lower serum creatinine and less tubular damage or apoptosis following ischemia/reperfusion injury.	Creatinine	87-97	adiponectin, C1Q and collagen domain containing	Mus musculus	30-41
23668201-6	2013	Median creatinine clearance (CrCl) was 25.33 (7.23-59.55) ml/min.	Creatinine	7-17	CRCL	Homo sapiens	29-33
23341218-0	2013	SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation.	Creatinine	35-45	solute carrier family 22 member 2	Homo sapiens	0-7
23341218-1	2013	Genome-wide association studies reported SLC22A2 variants to be associated with serum creatinine.	Creatinine	86-96	solute carrier family 22 member 2	Homo sapiens	41-48
23341218-2	2013	As SLC22A2 encodes the organic cation transporter 2 (OCT2), the association might be due to an effect on tubular creatinine handling.	Creatinine	113-123	solute carrier family 22 member 2	Homo sapiens	3-10
23341218-2	2013	As SLC22A2 encodes the organic cation transporter 2 (OCT2), the association might be due to an effect on tubular creatinine handling.	Creatinine	113-123	solute carrier family 22 member 2	Homo sapiens	23-51
23341218-2	2013	As SLC22A2 encodes the organic cation transporter 2 (OCT2), the association might be due to an effect on tubular creatinine handling.	Creatinine	113-123	solute carrier family 22 member 2	Homo sapiens	53-57
23341218-13	2013	Thus, SLC22A2 is associated with phenotypes of net tubular creatinine secretion and ESRD.	Creatinine	59-69	solute carrier family 22 member 2	Homo sapiens	6-13
23318499-7	2013	Furthermore, Gas6 concentrations positively correlated with blood pressure, creatinine, free fatty acids, C-reactive protein, leptin, and adiponectin during pregnancy.	Creatinine	76-86	growth arrest specific 6	Homo sapiens	13-17
23398216-10	2013	Plasma FGF-23 concentrations increased with increasing plasma creatinine concentrations and were significantly different between all groups (P &lt; .008).	Creatinine	62-72	fibroblast growth factor 23	Felis catus	7-13
23283135-5	2013	Compared with saline, a mixture of HSA and Trx, or Trx alone, intravenous HSA-Trx pretreatment significantly attenuated elevations in serum creatinine, blood urea nitrogen, and urinary N-acetyl-beta-D-glucosaminidase along with the decrease in creatinine clearance.	Creatinine	140-150	thioredoxin	Homo sapiens	43-46
22797889-8	2013	The established beta2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length.	Creatinine	130-140	beta-2-microglobulin	Homo sapiens	16-23
22797889-8	2013	The established beta2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length.	Creatinine	142-144	beta-2-microglobulin	Homo sapiens	16-23
23233713-5	2013	OS benefit with VMP was seen across prespecified patient subgroups (age &gt;= 75 years, stage III myeloma, creatinine clearance &lt; 60 mL/min).	Creatinine	107-117	neurensin 1	Homo sapiens	16-19
23375327-10	2013	Predictors of hemojuvelin on multiple regression analysis were TSAT and creatinine.	Creatinine	72-82	hemojuvelin BMP co-receptor	Homo sapiens	14-25
23375328-8	2013	Multiple regression analysis revealed renalase values to be 70% predicted by serum creatinine measurements.	Creatinine	83-93	renalase, FAD dependent amine oxidase	Homo sapiens	38-46
23428000-8	2013	Among continuous variables, statistically significant is the difference in the A-FABP level in relation to age (p = 0.002), creatinine (p = 0.026), insulin (p = 0.005), and BMI (p = 0.031).	Creatinine	124-134	fatty acid binding protein 4	Homo sapiens	79-85
23428000-9	2013	CONCLUSION: Our study confirmed the correlation of the A-FABP level with insulin resistance indices, BMI, age, gender, and insulin and creatinine levels in a group of asymptomatic first degree relatives of patients with cardiovascular diseases.	Creatinine	135-145	fatty acid binding protein 4	Homo sapiens	55-61
23380985-7	2012	CIMT was positively correlated with age, creatinine, uric acid, triglyceride, PTX-3, hs-CRP, and NLR, and negatively correlated with estimated glomerular filtration rate in all participants.	Creatinine	41-51	CIMT	Homo sapiens	0-4
22569819-7	2012	RESULTS: In the first treatment cycle, serum creatinine (SCr) levels in the patients with OCT2 808GG and 808GT were increased by 1.43- and 1.19-fold, respectively.	Creatinine	45-55	solute carrier family 22 member 2	Homo sapiens	90-94
22678524-5	2012	RESULTS: CEPO- and EPO-treated rats had improved serum creatinine levels compared with saline-treated remnant kidney model rats, although the Hb level was significantly increased in EPO-treated rats.	Creatinine	55-65	erythropoietin	Rattus norvegicus	10-13
22678524-5	2012	RESULTS: CEPO- and EPO-treated rats had improved serum creatinine levels compared with saline-treated remnant kidney model rats, although the Hb level was significantly increased in EPO-treated rats.	Creatinine	55-65	erythropoietin	Rattus norvegicus	19-22
22609259-7	2012	The concentration of circulating MCP-1 and the urinary MCP-1 to creatinine ratio (UMCR) were higher in the obese group and were correlated with fat mass and HOMA-IR.	Creatinine	64-74	C-C motif chemokine ligand 2	Homo sapiens	55-60
23013403-2	2012	High creatinine clearance (CrCl) may affect the pharmacokinetic / pharmacodynamic relationships of anti-infective drugs eliminated by the kidneys.	Creatinine	5-15	CRCL	Homo sapiens	27-31
23013403-5	2012	During the first 7 days following ICU admission, CrCl was measured from 24-hr urine samples (24-hr-UV/P creatinine) and estimated according to Cockcroft-Gault formula and the simplified Modification of Diet in Renal Disease (MDRD) equation.	Creatinine	104-114	CRCL	Homo sapiens	49-53
23013403-6	2012	High CrCl was defined as CrCl &gt;140 ml/min/1.73 m2 by 24-hr-UV/P creatinine.	Creatinine	67-77	CRCL	Homo sapiens	5-9
22718884-7	2012	DPP4 inhibition resulted in a significant dose-dependent decrease in serum creatinine (1.31 +- 0.32 and 0.70 +- 0.19 mg/dl for VG1 and VG10, respectively, vs. 1.91 +- 0.28 mg/dl for controls at 12 h; P &lt; 0.01).	Creatinine	75-85	dipeptidyl peptidase 4	Homo sapiens	0-4
26894024-9	2012	Plasma leptin levels were positively correlated with body mass index, fasting and postprandial blood glucose, hemoglobin A1c, total cholesterol, urinary albumin excretion, high-sensitivity C-reactive protein (hsCRP), and MCP-1 plasma levels, and negatively correlated with creatinine clearance values.	Creatinine	273-283	leptin	Homo sapiens	7-13
22331371-3	2012	METHODS: We validated the errors in eCrCl-AKI in a simulation study after various reductions in creatinine clearance (CrCl) at various levels of chronic kidney disease (CKD).	Creatinine	96-106	CRCL	Homo sapiens	37-41
22774989-6	2012	Urinary MBL was correlated significantly with the well-known clinical predictors for the prognosis of IgAN; that is, renal function (represented by serum creatinine and estimated glomerular filtration rate), proteinuria and arterial hypertension.	Creatinine	154-164	mannose binding lectin 2	Homo sapiens	8-11
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	beta-2-microglobulin	Homo sapiens	224-245
22305758-5	2012	PREDICTORS: Serum creatinine-based estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (eGFR(CKD-EPI)) and cystatin C, beta-trace protein (BTP), and beta(2)-microglobulin (B2M) levels.	Creatinine	18-28	beta-2-microglobulin	Homo sapiens	247-250
22087608-7	2012	AM5 infusion also induced significant increases in urine volume (HD 2-fold increment, P&lt;0.05) and urine sodium (2.7-fold increment, P&lt;0.01), potassium (1.7-fold increment, P&lt;0.05) and creatinine (1.4-fold increment, P&lt;0.05) excretion and creatinine clearance (60% increment, P&lt;0.05).	Creatinine	193-203	adrenomedullin 5 (putative)	Homo sapiens	0-3
22087608-7	2012	AM5 infusion also induced significant increases in urine volume (HD 2-fold increment, P&lt;0.05) and urine sodium (2.7-fold increment, P&lt;0.01), potassium (1.7-fold increment, P&lt;0.05) and creatinine (1.4-fold increment, P&lt;0.05) excretion and creatinine clearance (60% increment, P&lt;0.05).	Creatinine	250-260	adrenomedullin 5 (putative)	Homo sapiens	0-3
22497693-7	2012	However, in patients with renal impairment (creatinine clearance [CrCl], &lt;=80 mL/min), mean peak plasma concentrations were 68%-101% higher and apparent clearance was 43%-73% lower relative to those without impairment, precluding dalfampridine use in patients with moderate (CrCl, 30-50 mL/min) or severe renal impairment (CrCl, &lt;30 mL/min).	Creatinine	44-54	CRCL	Homo sapiens	66-70
22497693-7	2012	However, in patients with renal impairment (creatinine clearance [CrCl], &lt;=80 mL/min), mean peak plasma concentrations were 68%-101% higher and apparent clearance was 43%-73% lower relative to those without impairment, precluding dalfampridine use in patients with moderate (CrCl, 30-50 mL/min) or severe renal impairment (CrCl, &lt;30 mL/min).	Creatinine	44-54	CRCL	Homo sapiens	278-282
22497693-7	2012	However, in patients with renal impairment (creatinine clearance [CrCl], &lt;=80 mL/min), mean peak plasma concentrations were 68%-101% higher and apparent clearance was 43%-73% lower relative to those without impairment, precluding dalfampridine use in patients with moderate (CrCl, 30-50 mL/min) or severe renal impairment (CrCl, &lt;30 mL/min).	Creatinine	44-54	CRCL	Homo sapiens	278-282
22588810-8	2012	The erythropoietin-gentamicin-treated group revealed a significant decrease in plasma creatinine and urea, and a significant increase in the duodenal average force of contraction and motility index, and colonic frequency.	Creatinine	86-96	erythropoietin	Rattus norvegicus	4-18
22133274-8	2012	Polymorphisms of GP VI and VWF associated with lower creatinine levels during PUUV infection.	Creatinine	53-63	glycoprotein VI platelet	Homo sapiens	17-22
22237800-10	2012	At 48 h after CLP, creatinine clearance was significantly higher in the CLP+EPO rats than in the CLP rats.	Creatinine	19-29	erythropoietin	Rattus norvegicus	76-79
22383750-1	2012	BACKGROUND AND OBJECTIVES: In the albumin-to-creatinine ratio (spot-ACR), urine creatinine corrects for tonicity but also reflects muscle mass.	Creatinine	45-55	acrosin	Homo sapiens	68-71
22383750-1	2012	BACKGROUND AND OBJECTIVES: In the albumin-to-creatinine ratio (spot-ACR), urine creatinine corrects for tonicity but also reflects muscle mass.	Creatinine	80-90	acrosin	Homo sapiens	68-71
22541106-7	2012	Multivariate stepwise regression analysis revealed that serum uric acid, creatinine, P-LCR, urea nitrogen contributed to GMP-140 level (adjusted R(2) = 0.822).	Creatinine	73-83	selectin P	Homo sapiens	121-128
22071240-11	2012	Increasing (RAP+1)/PCWP was associated with the following variables: female gender; cardiomyopathy etiology besides ischemic or non-ischemic; prior sternotomies; and lower creatinine clearance (p &lt; 0.01 for all).	Creatinine	172-182	RAP1A, member of RAS oncogene family	Homo sapiens	12-17
22813935-10	2012	Also, serum omentin levels were found to be correlated with creatinine (r = 0.333, p = 0.002).	Creatinine	60-70	intelectin 1	Homo sapiens	12-19
22403621-10	2012	Furthermore, independent of blood pressure, periostin was strongly correlated with plasma creatinine, proteinuria and renal blood flow, hallmarks of hypertensive renal disease severity.	Creatinine	90-100	periostin	Homo sapiens	44-53
22295069-4	2012	Inactivation of HIF-2alpha, but not HIF-1alpha blunted the renal protective effects of UO, as demonstrated by much higher serum creatinine level and severer histological damage.	Creatinine	128-138	endothelial PAS domain protein 1	Mus musculus	16-26
22268784-2	2012	Different formulas like creatinine clearance (CrCl) in 24 h urine samples, Cockroft-Gault formula (CGF), and modification of diet in renal disease (MDRD) are being used to come up with an estimate.	Creatinine	24-34	CRCL	Homo sapiens	46-50
22583169-8	2012	Serum renalase correlated with creatinine, residual renal function, and transferrin saturation.	Creatinine	31-41	renalase, FAD dependent amine oxidase	Homo sapiens	6-14
21911128-4	2011	RESULTS: Creatinine clearance (CrCL) at 1 year after transplantation was 57.8 +- 15.5 mL/min with 61.9% patients presenting de novo chronic renal failure.	Creatinine	9-19	CRCL	Homo sapiens	31-35
21858386-6	2011	There was a positive significant correlation between serum MBL and FBG, HOMAIR index, serum urea, creatinine, and CRP levels.	Creatinine	98-108	mannose binding lectin 2	Homo sapiens	59-62
21652719-8	2011	Most of the renal injury (both histologically and biochemically as measured by blood urea nitrogen and creatinine) was abolished following HgCl(2) treatment of Oat1 knock-outs.	Creatinine	103-113	solute carrier family 22 member 6	Homo sapiens	160-164
21774806-7	2011	The partial correlation analysis demonstrating the correlation between cytokine levels when controlled for gender, systolic blood pressure, total cholesterol, HDL cholesterol, triglyceride, and serum creatinine levels further demonstrated that G-CSF, GM-CSF, and MCP-1 had significant negative correlations with age, whereas sCD40L and TGF-alpha had significant positive correlations.	Creatinine	200-210	colony stimulating factor 3	Homo sapiens	244-249
21959512-1	2011	BACKGROUND: The purpose of this study was to investigate the relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function (DGF) in kidney transplant recipients.	Creatinine	150-160	nitric oxide synthase 1 adaptor protein	Homo sapiens	77-116
21959512-1	2011	BACKGROUND: The purpose of this study was to investigate the relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function (DGF) in kidney transplant recipients.	Creatinine	150-160	nitric oxide synthase 1 adaptor protein	Homo sapiens	118-124
21959512-9	2011	We investigated the association of NOS1AP polymorphism with the recipient serum creatinine levels at day 1 and 180 days after kidney transplantation and the occurrence of DGF.	Creatinine	80-90	nitric oxide synthase 1 adaptor protein	Homo sapiens	35-41
21951883-5	2011	Correlation with PCOP and endogenous creatinine clearance (CrCl) was calculated.	Creatinine	37-47	CRCL	Homo sapiens	59-63
21353588-11	2011	Using Pearson"s correlation coefficient, PVR at 48 h after PEA could be estimated as PVR = 123.266+135.471 x creatinine-22.053 x desobliterated segments + 3.248 x systolic PAP (P &lt; 0.01, R(2) = 0.401, 95% confidence interval = 0.464-0.830).	Creatinine	109-119	PVR cell adhesion molecule	Homo sapiens	41-44
21353588-11	2011	Using Pearson"s correlation coefficient, PVR at 48 h after PEA could be estimated as PVR = 123.266+135.471 x creatinine-22.053 x desobliterated segments + 3.248 x systolic PAP (P &lt; 0.01, R(2) = 0.401, 95% confidence interval = 0.464-0.830).	Creatinine	109-119	PVR cell adhesion molecule	Homo sapiens	85-88
21272915-9	2011	The multivariate logistic regression analysis showed that men with PSA&gt;=4.0 ng m L(-1) had an odds ratio (OR) of 0.4 (95% CI=0.1-0.9) to have BCd&gt;0.49 mug L(-1), and an OR of 0.4 (95% CI=0.2-1.0) to have UCd&gt;0.45 mug g(-1) creatinine.	Creatinine	232-242	kallikrein related peptidase 3	Homo sapiens	67-70
21543026-11	2011	Univariate analysis indicated that beta2-M was positively correlated with nPNA, duration of HD, BMI, and the concentrations of creatinine, albumin, BUN, and hs-CRP, but was negatively correlated with HDL-C concentration.	Creatinine	127-137	beta-2-microglobulin	Homo sapiens	35-42
21266908-3	2011	METHODS: Routine laboratory data obtained before ART initiation were used to evaluate prevalence and predictors of decreased creatinine clearance (CrCl) in participants of the MTCT-Plus Initiative from 7 sub-Saharan countries.	Creatinine	125-135	CRCL	Homo sapiens	147-151
21225309-4	2011	The urinary beta(2)-microglobulin-creatinine ratio (UBCR) was assessed in morning spot urine samples.	Creatinine	34-44	beta-2-microglobulin	Homo sapiens	12-33
21328391-9	2011	Patients with high IDO levels had higher maximum serum creatinine (379 vs. 102 micromol/L, P&lt;0.001), plasma C-reactive protein (104.1 vs. 72.1 mg/L, P=0.029), and blood leukocyte values (11.9 vs. 9.0 x 10(9) /L, P&lt;0.001) compared to patients with kyn/trp ratio &lt;= 202 micromol/mmol.	Creatinine	55-65	indoleamine 2,3-dioxygenase 1	Homo sapiens	19-22
20836698-8	2011	Lentiviral transduction with the VECAD-HO-1 construct attenuated the increase in blood pressure (p &lt; 0.05), improved vascular relaxation, increased plasma adiponectin, and prevented the elevation in urinary protein and plasma creatinine in Ang II-treated rats.	Creatinine	229-239	heme oxygenase 1	Homo sapiens	39-43
20709741-7	2011	RESULTS: There was a significant correlation between serum levels of soluble TREM-1 and serum creatinine levels among all patients (r = 0.554, P &lt; 0.0001).	Creatinine	94-104	triggering receptor expressed on myeloid cells 1	Homo sapiens	77-83
20709741-10	2011	CONCLUSIONS: The serum ratio of soluble TREM-1 to creatinine may be a useful marker for detection of infectious complications in MPO-ANCA-associated vasculitis.	Creatinine	50-60	triggering receptor expressed on myeloid cells 1	Homo sapiens	40-46
21242114-9	2011	The certified values were further confirmed by an international intercomparison for the determination of creatinine in human serum (Consultative Committee for Amount of Substance, CCQM) of K80 (CCQM-K80).	Creatinine	105-115	keratin 80	Homo sapiens	189-192
21242114-9	2011	The certified values were further confirmed by an international intercomparison for the determination of creatinine in human serum (Consultative Committee for Amount of Substance, CCQM) of K80 (CCQM-K80).	Creatinine	105-115	keratin 80	Homo sapiens	194-202
21042828-10	2011	In the CAM group, the changes of serum creatinine also showed a significant positive correlation with those of urinary ACR, urinary MCP-1, urinary IL-18 and serum levels of soluble ICAM-1.	Creatinine	39-49	C-C motif chemokine ligand 2	Homo sapiens	132-137
21190684-6	2011	RESULTS: The U-Cd BMDL for beta2-MG was 3.5mug/g creatinine in men and 3.7 mug/g creatinine in women.	Creatinine	49-59	beta-2-microglobulin	Homo sapiens	27-35
20840479-6	2010	The overexpression of hCD39 conferred protection in a model of warm renal IRI, with reduced histological injury, less apoptosis and preserved serum creatinine and urea levels.	Creatinine	148-158	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	22-27
20861081-8	2010	Furthermore, histopatological analysis, expression of the tissue injury marker Havcr1, and measurement of serum creatinine demonstrate that reduction of Fstl1 expression sensitizes the kidney to acute cisplatin nephrotoxicity, suggesting a role for FSTL1-mediated Il-1beta suppression in protection of the kidney from acute nephrotoxic injury.	Creatinine	112-122	follistatin-like 1	Mus musculus	153-158
20977251-1	2010	MP2 calculations with cc-pVTZ basis set were used to analyze intermolecular interactions in F(3)CX   HMgH   Y and F(3)CX   Y   HMgH triads (X = Cl, Br; Y = HCN, and HNC) which are connecting with three kinds of unusual weak interactions, namely halogen-hydride, dihydrogen, and sigma-hole.	Creatinine	253-260	tryptase pseudogene 1	Homo sapiens	0-3
20558004-8	2010	Albumin-creatinine ratio per % burn (ACR, a marker of capillary leak) was lower in the HES-supplemented group at 12h after burn (p=0.0310).	Creatinine	8-18	acrosin	Homo sapiens	37-40
21034455-6	2010	T2DM patients in whom OPN levels were greater than the median value had higher serum creatinine levels, a greater prevalence of mild or moderate renal insufficiency, a higher incidence of CAD, and lower eGFR (all P &lt; 0.05) than T2DM patients in whom OPN levels were the same as or lower than the median value.	Creatinine	85-95	secreted phosphoprotein 1	Homo sapiens	22-25
20567246-6	2010	Promising findings from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study on microvascular outcomes are countered by elevations in participants" homocysteine and creatinine levels that might potentially attenuate the benefits of PPARalpha activation.	Creatinine	186-196	peroxisome proliferator activated receptor alpha	Homo sapiens	253-262
20629321-6	2010	The expression of nephrin and the number of podocyte were negatively correlated with the 24-hour urine protein, blood urea nitrogen and serum creatinine; while the expression of VEGF was positively correlated with the 24-hour urine protein, blood urea nitrogen and serum creatinine.	Creatinine	142-152	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	18-25
20629321-6	2010	The expression of nephrin and the number of podocyte were negatively correlated with the 24-hour urine protein, blood urea nitrogen and serum creatinine; while the expression of VEGF was positively correlated with the 24-hour urine protein, blood urea nitrogen and serum creatinine.	Creatinine	271-281	vascular endothelial growth factor A	Rattus norvegicus	178-182
20534231-2	2010	The aim of this study was to evaluate kidney weight (cadaveric donor) and its relationship to creatinine clearance (CrCl) after 12 months posttransplantation.	Creatinine	94-104	CRCL	Homo sapiens	116-120
19958207-11	2010	Gb3 concentrations in healthy controls were &lt;4 mg/L in EDTA-plasma and &lt;10 microg/mmol creatinine in urine.	Creatinine	93-103	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	0-3
21239831-4	2010	Renal complete response (CRrenal) is defined as sustained (i.e., lasting at least 2 months) improvement of creatinine clearance (CRCL) from under 50 mL/min at baseline to 60 mL/min or above.	Creatinine	107-117	CRCL	Homo sapiens	129-133
19943769-1	2010	OBJECTIVE: In hypertensive pregnancy, to compare 24hr creatinine clearance (CrCl) with formulae-derived renal function (Cockcroft-Gault (CG) or Modified Diet in Renal Disease (MDRD)).	Creatinine	54-64	CRCL	Homo sapiens	76-80
20122555-9	2010	CONCLUSIONS: Higher baseline serum beta2-microglobulin concentration could be a promising risk marker in acute heart failure patients with creatinine &lt; or =3.0 mg/dL.	Creatinine	139-149	beta-2-microglobulin	Homo sapiens	35-54
20626027-8	2010	Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P&lt;0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006).	Creatinine	205-215	matrix metallopeptidase 8	Homo sapiens	70-75
20460939-1	2010	BACKGROUND/AIMS: Patients treated with peroxisome proliferator-activated receptor analogs (PPAR) alpha or alpha/gamma may develop a transient and reversible increase in serum creatinine, the mechanism of which remains obscure.	Creatinine	175-185	peroxisome proliferator activated receptor alpha	Homo sapiens	39-102
19640916-7	2009	In addition, MMP-1, -3, -7, -9 correlated significantly with leukocytes, MMP-1, and TIMP-1 with thrombocytes, MMP-8 with fibrinogen, and MMP-7 with creatinine.	Creatinine	148-158	matrix metallopeptidase 1	Homo sapiens	13-18
19640916-7	2009	In addition, MMP-1, -3, -7, -9 correlated significantly with leukocytes, MMP-1, and TIMP-1 with thrombocytes, MMP-8 with fibrinogen, and MMP-7 with creatinine.	Creatinine	148-158	matrix metallopeptidase 7	Homo sapiens	137-142
19262583-7	2009	In the total population, resistin was associated with 24-h systolic BP (r=0.244, P&lt;0.05), serum creatinine (r=0.311, P=0.007) and eGFR (r=-0.519, P&lt;0.0001).	Creatinine	99-109	resistin	Homo sapiens	25-33
19508392-8	2009	KEY RESULTS: Mice treated with GSK-3 inhibitors showed decreased mortality, renal tubular dilatation, vacuolization and sloughing, blood urea nitrogen, creatinine and renal cell apoptosis in response to endotoxaemia.	Creatinine	152-162	glycogen synthase kinase 3 beta	Mus musculus	31-36
19409809-4	2009	Urinary MCP-1/creatinine ratios were found to be significantly higher in patients with macroalbuminuria (3.3- and 2.1-fold higher (p&lt;0.01) than normoalbuminuric and microalbuminuric patients, respectively).	Creatinine	14-24	C-C motif chemokine ligand 2	Homo sapiens	8-13
19694200-7	2009	Radial artery stiffness and urinary albumin/creatinine ratios of the adolescents with DM1 were not different from controls.	Creatinine	44-54	immunoglobulin heavy diversity 1-7	Homo sapiens	86-89
19131464-5	2009	RESULTS: Elevated ACR levels (&gt;or=30 mg/g creatinine) were present at baseline in 198 (6.2%) of 3,188 participants: placebo 5.3%, metformin 6.5%, and intensive lifestyle (ILS) 6.8%.	Creatinine	45-55	acrosin	Homo sapiens	18-21
19152009-9	2009	Among the patients, the CC16/creatinine ratio was correlated with both the beta2-microglobulin/creatinina ratio (r = 0.76, P &lt; 0.001) and the NAG/creatinine ratio (r = 0.6, P &lt; 0.001).	Creatinine	29-39	secretoglobin family 1A member 1	Homo sapiens	24-28
19152009-9	2009	Among the patients, the CC16/creatinine ratio was correlated with both the beta2-microglobulin/creatinina ratio (r = 0.76, P &lt; 0.001) and the NAG/creatinine ratio (r = 0.6, P &lt; 0.001).	Creatinine	29-39	beta-2-microglobulin	Homo sapiens	75-94
19152009-9	2009	Among the patients, the CC16/creatinine ratio was correlated with both the beta2-microglobulin/creatinina ratio (r = 0.76, P &lt; 0.001) and the NAG/creatinine ratio (r = 0.6, P &lt; 0.001).	Creatinine	149-159	secretoglobin family 1A member 1	Homo sapiens	24-28
18753292-6	2008	After terlipressin the excretion of AQP2 increased by 89% [144 ng/mmol creatinine, 95% confidence interval (CI) 73-214 ng/mmol creatinine, P = 0.001].	Creatinine	71-81	aquaporin 2	Homo sapiens	36-40
18753292-6	2008	After terlipressin the excretion of AQP2 increased by 89% [144 ng/mmol creatinine, 95% confidence interval (CI) 73-214 ng/mmol creatinine, P = 0.001].	Creatinine	127-137	aquaporin 2	Homo sapiens	36-40
19169600-4	2008	Since a reduction in Creatinine Clearance (CrCl) to the level of 60 ml/min/1.73m2 signals the onset of kidney malfunction and since a concurrent increase in blood pressure (BP) &gt;140/90 mm Hg, contributes greatly to an unfavorable cardiovascular prognosis, it seemed prudent to examine possible changes in these and in other relevant variables in a group of young Army men, which may have developed over a 34 year period of time.	Creatinine	21-31	CRCL	Homo sapiens	43-47
18624904-5	2008	RESULTS: For a one standard deviation higher value of the log-transformed ratio between albumin and creatinine (ACR), the mortality rate ratio for all-cause mortality was 1.21 when adjusted for age, gender, established cardiovascular risk factors as well as fibrinogen and white blood cell count (P &lt; 0.001).	Creatinine	100-110	acrosin	Homo sapiens	112-115
18974575-7	2008	The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 +/- 50.23 and 630.87 +/- 318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients and healthy controls (63.85 +/- 21.15 and 61.50 +/- 24.81 ng/gm creatinine, p p 0.001), HbA1c (r= 0.55, p 0.001) and inversely with eGFR (r=-0.60, p&lt; 0.001).	Creatinine	139-149	C-C motif chemokine ligand 2	Homo sapiens	12-17
18974575-7	2008	The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 +/- 50.23 and 630.87 +/- 318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients and healthy controls (63.85 +/- 21.15 and 61.50 +/- 24.81 ng/gm creatinine, p p 0.001), HbA1c (r= 0.55, p 0.001) and inversely with eGFR (r=-0.60, p&lt; 0.001).	Creatinine	271-281	C-C motif chemokine ligand 2	Homo sapiens	12-17
19080694-10	2008	The serum BUN and Cr levels of the IR + EPO group were (12.3 +/- 6.0) mmol/L and (51 +/- 5) micromol/L respectively, both significantly lower than those of the IR group [(29.9 +/- 3.7) mmol/L and (141 +/- 5) micromol/L respectively, both P &lt; 0.01].	Creatinine	18-20	erythropoietin	Rattus norvegicus	40-43
19080126-15	2008	Finally the expression of CTGF after the irradiation of the kidney positively correlated with the levels of blood urea nitrogen and serum creatinine.	Creatinine	138-148	cellular communication network factor 2	Rattus norvegicus	26-30
18752646-1	2008	There is still incomplete evidence for the cerebral clearance of creatinine (CTN) which is an endogenous convulsant and accumulates in the brain and CSF of patients with renal failure.	Creatinine	65-75	colony stimulating factor 2	Homo sapiens	149-152
18752646-1	2008	There is still incomplete evidence for the cerebral clearance of creatinine (CTN) which is an endogenous convulsant and accumulates in the brain and CSF of patients with renal failure.	Creatinine	77-80	colony stimulating factor 2	Homo sapiens	149-152
18752646-6	2008	The inhibitory effects of inhibitors and antisense oligonucleotides on CTN uptake by isolated choroid plexus indicated the involvement of rat organic cation transporter 3 (rOCT3) and creatine transporter (CRT) in CTN transport.	Creatinine	71-74	solute carrier family 22 member 8	Rattus norvegicus	172-177
18752646-6	2008	The inhibitory effects of inhibitors and antisense oligonucleotides on CTN uptake by isolated choroid plexus indicated the involvement of rat organic cation transporter 3 (rOCT3) and creatine transporter (CRT) in CTN transport.	Creatinine	213-216	solute carrier family 22 member 8	Rattus norvegicus	172-177
18596116-3	2008	RESULTS: Those not on lithium demonstrated normal urinary concentrating ability (958 +/- 51 mOsm/kg) and increased urinary excretion of AQP2 (98 +/- 21 fmol/micromol creatinine) and cAMP (410 +/- 15 pmol/micromol creatinine).	Creatinine	166-176	aquaporin 2	Homo sapiens	136-140
18052934-8	2008	Ucn2, both separately and in conjunction with captopril, increased urine output, sodium and creatinine excretion and creatinine clearance.	Creatinine	92-102	urocortin-2	Ovis aries	0-4
18052934-8	2008	Ucn2, both separately and in conjunction with captopril, increased urine output, sodium and creatinine excretion and creatinine clearance.	Creatinine	117-127	urocortin-2	Ovis aries	0-4
18332284-7	2008	Apart from the association with thrombotic microangiopathy, ADAMTS13 was inversely associated with creatinine (r=-0.42; P=0.008).	Creatinine	99-109	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	60-68
17449565-8	2008	In biological monitoring, urinary 3OH-BaP was found in median concentrations of 0.8 ng/g creatinine (crea) and the 95th percentile of 6.7 ng/g crea.	Creatinine	89-99	prohibitin 2	Homo sapiens	38-41
17449565-8	2008	In biological monitoring, urinary 3OH-BaP was found in median concentrations of 0.8 ng/g creatinine (crea) and the 95th percentile of 6.7 ng/g crea.	Creatinine	89-93	prohibitin 2	Homo sapiens	38-41
17449565-8	2008	In biological monitoring, urinary 3OH-BaP was found in median concentrations of 0.8 ng/g creatinine (crea) and the 95th percentile of 6.7 ng/g crea.	Creatinine	101-105	prohibitin 2	Homo sapiens	38-41
18023222-7	2008	This means that the levels of urinary excretion of Gb3/creatinine in children and adults with Fabry disease are directly related to the types of mutations.	Creatinine	55-65	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	51-54
18044729-9	2008	Among men with zinc intake less than the median level of 12.67 mg/day, an increase in 1 microg/g creatinine cadmium exposure was associated with a 35% increase in PSA level.	Creatinine	97-107	kallikrein related peptidase 3	Homo sapiens	163-166
18025797-5	2008	Urinary osteopontin concentration did not correlate with urinary calcium concentration in premature infants, while there was a correlation between the osteopontin/creatinine ratio and calcium/creatinine ratios in premature infants.	Creatinine	192-202	secreted phosphoprotein 1	Homo sapiens	151-162
18087173-10	2008	Immunostainable SCF protein in each of the 3 compartments, glomerular, tubular and interstitial, showed a positive linear correlation with serum creatinine, proteinuria, glomerulosclerosis score and interstitial fibrosis scores.	Creatinine	145-155	KIT ligand	Rattus norvegicus	16-19
17934191-4	2008	The results showed that increases in urinary Kim-1 and kidney Kim-1/Havcr1 gene expression paralleled the degree of severity of renal histopathology and were detected at lower doses of nephrotoxicants when compared to blood urea nitrogen (BUN), serum creatinine, and urinary N-acetyl-beta-D-glucosaminidase (NAG).	Creatinine	251-261	hepatitis A virus cellular receptor 1	Rattus norvegicus	62-67
17934191-4	2008	The results showed that increases in urinary Kim-1 and kidney Kim-1/Havcr1 gene expression paralleled the degree of severity of renal histopathology and were detected at lower doses of nephrotoxicants when compared to blood urea nitrogen (BUN), serum creatinine, and urinary N-acetyl-beta-D-glucosaminidase (NAG).	Creatinine	251-261	hepatitis A virus cellular receptor 1	Rattus norvegicus	68-74
18047927-7	2008	In the patients with acute rejection MCP-1 level was ten-fold higher than in the patients with a stable graft function (6.1+/-3.4 vs 0.6+/-0.4 ng/mg creatinine).	Creatinine	149-159	C-C motif chemokine ligand 2	Homo sapiens	37-42
17971303-2	2007	Blood urea nitrogen (BUN) and serum creatinine were significantly higher in ASK1+/+ mice than in ASK1-/- mice after I/R injury.	Creatinine	36-46	mitogen-activated protein kinase kinase kinase 5	Mus musculus	76-80
17724144-8	2007	Significant hepcidin increase ( &gt; or = 10 ng/mg creatinine) was observed in 74% of controls, 15% of homozygotes, and 32% of heterozygotes.	Creatinine	51-61	hepcidin antimicrobial peptide	Homo sapiens	12-20
18293814-2	2007	Creatinine clearance (CrCl) provides a more accurate method for perioperative risk assessment of renal function than serum creatinine.	Creatinine	0-10	CRCL	Homo sapiens	22-26
17998026-14	2007	The PPAR-alpha mRNA expression was inversely correlated with serum creatinine and lipids in the overall rats.	Creatinine	67-77	peroxisome proliferator activated receptor alpha	Rattus norvegicus	4-14
18089324-8	2007	In the two cases in which p27kip1 expression was remarkably decreased, elevation of the serum creatinine level was recognized at the time of biopsy, resulting in kidney transplant loss.	Creatinine	94-104	cyclin dependent kinase inhibitor 1B	Homo sapiens	26-33
17785630-5	2007	Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P&lt;0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein.	Creatinine	74-84	resistin	Homo sapiens	14-22
17785630-6	2007	In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes.	Creatinine	163-173	resistin	Homo sapiens	48-56
17687453-9	2007	Three months after cessation of well water consumption, this child"s corrected beta-2-microglobulin level had fallen to 52 microg/mmol creatinine.	Creatinine	135-145	beta-2-microglobulin	Homo sapiens	79-99
18293690-5	2007	Osteopontin was correlated with creatinine clearance (P = 0.037).	Creatinine	32-42	secreted phosphoprotein 1	Homo sapiens	0-11
17639610-5	2007	The levels of HO-1 showed a significant positive correlated with parameters of renal function, creatinine clearance, and renal blood flow and urine output (AUC; r = 0.8042, P = 0.03; r = 0.6028, P = 0.04; r = 0.6055, P = 0.04), demonstrating a possible protective role of this gene in this model of renal transplantation.	Creatinine	95-105	heme oxygenase 1	Homo sapiens	14-18
17514743-4	2007	The authors measured performance status at study entry and used age, weight, and baseline creatinine to calculate creatinine clearance (CrCl).	Creatinine	114-124	CRCL	Homo sapiens	136-140
17580141-4	2007	We calculated creatinine clearance (CrCl) at 1, 2, and 3 years posttransplant.	Creatinine	14-24	CRCL	Homo sapiens	36-40
17456199-7	2007	rAAV1-IL-10 treatment resulted in lower BUN and creatinine levels (p&lt;0.001), as well as increased allograft survival rates from 22% to 90%.	Creatinine	48-58	interleukin 10	Rattus norvegicus	6-11
17303077-6	2007	Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P=0.0318) or serum creatinine (P=0.0092).	Creatinine	173-183	resistin	Homo sapiens	6-14
17383292-6	2007	Creatinine clearance (CrCl) was estimated by using the Cockcroft-Gault equation and categorized as &gt; or = 90 mL/min (normal CrCl), 60 to 89 mL/min (mildly reduced CrCl), and &lt; 60 mL/min (moderately reduced CrCl).	Creatinine	0-10	CRCL	Homo sapiens	22-26
17329577-10	2007	Depletion of gammadelta T cells using anti-TCR gammadelta antibody resulted in worsening of serum creatinine, glomerulosclerosis, and interstitial inflammation.	Creatinine	98-108	T cell receptor alpha variable 6-3	Mus musculus	43-46
17394854-6	2007	sTNFRI, IL-1Ra and ICAM-1 early showed significantly higher levels in relation with serum creatinine, and these and also IL-6 in those with PO2 below 60 mmHg.	Creatinine	90-100	interleukin 1 receptor antagonist	Homo sapiens	8-14
17368275-3	2007	Fibrates, most likely by an effect mediated by peroxisome proliferator-activated receptor-alpha, may reversibly increase creatinine and homocysteine but are not associated with an increased risk for renal failure in clinical trials.	Creatinine	121-131	peroxisome proliferator activated receptor alpha	Homo sapiens	47-95
17519026-5	2007	The inverses of serum creatinine, cystatin C, and B2M were correlated with creatinine clearance (CrC) using a 24-hour urine sample and CrC estimation by Schwartz formula (Schwartz).	Creatinine	75-85	beta-2-microglobulin	Homo sapiens	50-53
17581273-2	2007	Herrero-Morin and colleagues performed a cross-sectional analysis of the ability of cystatin C and beta2 microglobulin to reflect creatinine clearance in pediatric patients with AKI.	Creatinine	130-140	beta-2-microglobulin	Homo sapiens	99-118
17971362-4	2007	Two renal function estimates, the CG and the MDRD, were compared with the 24 h creatinine clearance (CrCl).	Creatinine	79-89	CRCL	Homo sapiens	101-105
16929540-10	2006	In hemodialyzed patients hepcidin, correlated significantly with triglycerides, albumin, creatinine, urea, residual renal function, and hsCRP.	Creatinine	89-99	hepcidin antimicrobial peptide	Homo sapiens	25-33
16929540-12	2006	Multiple regression analysis in hemodialyzed patients showed that hepcidin was independently related to creatinine, triglycerides, and residual renal function.	Creatinine	104-114	hepcidin antimicrobial peptide	Homo sapiens	66-74
16911085-6	2006	The relation of serum leptin levels to serum and urinary Mg/urinary creatinine levels was assessed.	Creatinine	68-78	leptin	Homo sapiens	22-28
16911085-9	2006	Leptin levels were correlated with urinary Mg/urinary creatinine levels in both girls and boys (r = 0.39, P = 0.02 and r = 0.37, P = 0.03, respectively).	Creatinine	54-64	leptin	Homo sapiens	0-6
16911085-10	2006	In a multivariate regression model, leptin emerged as independent correlates for mean urinary Mg/urinary creatinine in both girls and boys with the total variance explained being 14%, and 15%, respectively.	Creatinine	105-115	leptin	Homo sapiens	36-42
16436274-9	2006	The BMDL for the 84% cut-off value of beta2-MG, setting an abnormal value at 5%, was 2.4 microg/g creatinine (cr) in men and 3.3 microg/g cr in women.	Creatinine	98-108	beta-2-microglobulin	Homo sapiens	38-46
16436274-9	2006	The BMDL for the 84% cut-off value of beta2-MG, setting an abnormal value at 5%, was 2.4 microg/g creatinine (cr) in men and 3.3 microg/g cr in women.	Creatinine	91-93	beta-2-microglobulin	Homo sapiens	38-46
16436274-9	2006	The BMDL for the 84% cut-off value of beta2-MG, setting an abnormal value at 5%, was 2.4 microg/g creatinine (cr) in men and 3.3 microg/g cr in women.	Creatinine	98-100	beta-2-microglobulin	Homo sapiens	38-46
16793966-2	2006	Recent studies have shown that the preproghrelin Leu72Met polymorphism is associated with serum creatinine (Scr) concentration in type 2 diabetes; 72Met carriers exhibited lower Scr levels as compared with the 72Met non-carriers.	Creatinine	96-106	ghrelin and obestatin prepropeptide	Homo sapiens	35-48
16791912-8	2006	The BMDL for the 84% cut-off value of beta(2)-MG, setting an abnormal value at 5%, was 2.0 microg g(-1) creatinine (cr) in men and 1.6 microg g(-1) cr in women.	Creatinine	104-114	beta-2-microglobulin	Homo sapiens	38-48
16791912-8	2006	The BMDL for the 84% cut-off value of beta(2)-MG, setting an abnormal value at 5%, was 2.0 microg g(-1) creatinine (cr) in men and 1.6 microg g(-1) cr in women.	Creatinine	93-95	beta-2-microglobulin	Homo sapiens	38-48
16791912-8	2006	The BMDL for the 84% cut-off value of beta(2)-MG, setting an abnormal value at 5%, was 2.0 microg g(-1) creatinine (cr) in men and 1.6 microg g(-1) cr in women.	Creatinine	104-106	beta-2-microglobulin	Homo sapiens	38-48
17048203-5	2006	RESULTS: After excluding 52 participants, we found that in 848 participants (702 men, 146 women) the overall prevalence of excess ACR, using a 30 mg/g creatinine cutoff, was 9.3% (9.7% of men, 7.5% of women, p=0.16); adopting a gender-dependent cutoff, we found that the overall prevalence was 13.6% (15.1% of men, 6.2% of women, p&lt;0.01).	Creatinine	151-161	acrosin	Homo sapiens	130-133
16501491-8	2006	Cystatin-C and serum beta(2)-M showed a strong correlation with creatinine clearance and age, while NAG positively correlated with proteinuria.	Creatinine	64-74	beta-2-microglobulin	Homo sapiens	21-30
16766368-7	2006	An increased percentage of IL-10 producers correlated positively with anti-dsDNA-IgG and proteinuria, and a small gain in IL-4 producers correlated with plasma creatinine.	Creatinine	160-170	interleukin 4	Mus musculus	122-126
16189276-4	2006	The incidence of acute renal failure and serum creatinine levels in patients with ADAMTS13 activity levels lower than 20% (incidence, 41.2%; creatinine, 160 +/- 150 microM [1.81 +/- 1.70 mg/dL]) (P &lt; .05) were significantly higher than they were in patients with ADAMTS13 activity levels higher than 20% (incidence, 15.4%; creatinine, 84 +/- 67 microM [0.95 +/- 0.76 mg/dL]) (P &lt; .01).	Creatinine	47-57	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	82-90
16249281-9	2006	Resistin levels were higher in participants with established nephropathy (albumin to creatinine ratio &gt;300 mg/g, n = 26) compared with those with normo- (n = 122) or microalbuminuria (n = 42).	Creatinine	85-95	resistin	Homo sapiens	0-8
15811876-10	2005	Pulsatile leptin independently predicted urine free cortisol/creatinine (15% of variability).	Creatinine	61-71	leptin	Homo sapiens	10-16
16082328-5	2005	Mean change in creatinine clearance (CrCl) from 3 to 12 months posttransplantation was calculated.	Creatinine	15-25	CRCL	Homo sapiens	37-41
16025186-4	2005	Reactivity with aryldiazonium cations of all the hydrides was investigated and found to proceed only with the PtHClP2 complex to yield the aryldiazene [PtCl(ArN=NH)P2]BF4[P = PPh(OEt)2] derivative.	Creatinine	49-57	enolase 1	Homo sapiens	175-178
16061836-7	2005	RESULTS: Expression of 11beta-HSD2 did not correlate with blood pressure or urinary Na/K ratio, but a significant positive correlation with creatinine clearance was observed (r = 0.284; P &lt; 0.01).	Creatinine	140-150	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	23-34
15984523-5	2005	After MTX infusion, the level of serum creatinine increased.	Creatinine	39-49	metaxin 1	Homo sapiens	6-9
16357730-1	2005	BACKGROUND: Dosing of allopurinol should be corrected depending on renal function, but corrections based on either plasma creatinine (Pcr) or creatinine clearance (CrCl) have been suggested to be minimal standards of care.	Creatinine	142-152	CRCL	Homo sapiens	164-168
16209246-7	2005	IL-1ra serum concentration and urinary excretion were lower in the patients than in the controls (202 vs 330 ng/ml and 970 vs 1607 ng/mg creatinine respectively; p &lt; 0.05 both).	Creatinine	137-147	interleukin 1 receptor antagonist	Homo sapiens	0-6
15694998-5	2005	Creatinine clearance (CrCl; ml/mn/1.73 m2) was calculated (Schwartz) before transplant, then at 1 month, 6 months, and 1 year, and yearly up to 7 years.	Creatinine	0-10	CRCL	Homo sapiens	22-26
15221207-1	2005	We previously observed that a creatinine clearance (CrCl) of &lt;65 ml/min is a significant and independent risk factor for the number of fallers and falls in a community-dwelling elderly population and postulated that this increased risk is due to the associated significant lower D-hormone serum levels.	Creatinine	30-40	CRCL	Homo sapiens	52-56
16176176-8	2005	Sensitivity/specificity to detect a &lt;80 mL/min CG CrCl was 88/97% for cystatin C vs. 48/100% for creatinine (laboratory cut-off).	Creatinine	100-110	CRCL	Homo sapiens	53-57
15602665-9	2005	Plasma U-II concentrations (pg/ml) were decreased during relapse (20.11+/-14.43 in relapse, 38.94+/-23.86 in remission, P&lt;0.05), whereas urinary U-II levels (pg/mg urinary creatinine) were significantly higher in relapse than in remission (37.31+/-28.43 in relapse, 31.09+/-21.10 in remission, P&lt;0.05).	Creatinine	175-185	urotensin 2	Homo sapiens	7-11
16334978-9	2005	The tubulointerstitial MCP-1 immunoexpression was significantly correlated with monocyte/macrophage interstitial infiltrates, the immunoexpression of TGF-beta-1 in tubuli and interstitium as well as serum creatinine.	Creatinine	205-215	C-C motif chemokine ligand 2	Homo sapiens	23-28
15808627-9	2005	Creatinine values were significantly lower among the IGL-1 group from 2 to 14 days postoperative and at 1 month.	Creatinine	0-10	immunoglobulin lambda like polypeptide 1	Homo sapiens	53-58
15808627-11	2005	IGL-1 kidneys had a superior creatinine clearance during the first 15 postoperative days compared to UW kidneys.	Creatinine	29-39	immunoglobulin lambda like polypeptide 1	Homo sapiens	0-5
15556050-8	2004	Trx elevation correlated well with increased oxidative stress (lipid peroxides, P&lt;0.0001), circulatory P-selectin (P&lt;0.0001), morning level of free salivary cortisol (P=0.0002), and serum creatinine (P=0.0417), but not with pro-inflammatory cytokines TNF and IL-6.	Creatinine	194-204	thioredoxin	Homo sapiens	0-3
15770047-8	2004	In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r = 0.36, p = 0.037 versus r = 0.37, p = 0.027, respectively), whereas triglyceride had a negative correlation (r = -0.34, p = 0.046).	Creatinine	57-67	leptin	Homo sapiens	32-38
15492946-1	2004	BACKGROUND: Chronic kidney disease and a low creatinine clearance (CrCl) are relatively common, particularly in the aged population.	Creatinine	45-55	CRCL	Homo sapiens	67-71
15456536-5	2004	RESULTS: Ulinastatin significantly reduced the increase in blood urea nitrogen and creatinine produced by renal ischemia-reperfusion, suggesting an improvement in renal function.	Creatinine	83-93	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	9-20
15384013-3	2004	Renal insufficiency is defined as a creatinine clearance (CrCl) less than 60 mL/min (&lt;1.0 mL/s).	Creatinine	36-46	CRCL	Homo sapiens	58-62
15373927-7	2004	Both the renal and the nonrenal clearance of desmopressin were found to vary with the creatinine clearance (CrCL).	Creatinine	86-96	CRCL	Homo sapiens	108-112
15523124-7	2004	Following alternate day pu1ses the median urinary albumin to creatinine ratio decreased from 9.2 to 1.5 (P less tha 0.005) in dexamethasone group and from 12.1 to 0.7 (P less than 0.005) in methylprednisolone group.	Creatinine	61-71	Spi-1 proto-oncogene	Homo sapiens	24-27
15525586-8	2004	Urinary VEGF levels also showed a significant positive correlation with UAE (r=0.262, P=0.045) and serum creatinine (r=0.398, P=0.044), and were found to be independently correlated with UAE by Spearman"s rank correlation.	Creatinine	105-115	vascular endothelial growth factor A	Rattus norvegicus	8-12
15458431-8	2004	Urinary excretion of AQP-2 was 187.3 +/- 50.2 fmol/mg creatinine in the control subjects.	Creatinine	54-64	aquaporin 2	Homo sapiens	21-26
15458431-10	2004	Urinary excretion of AQP-2 was elevated to 1144.4 +/- 257.5 and 990.5 +/- 176.0 fmol/mg creatinine in the patients with NYHA class III and class IV, respectively, values significantly greater than the control subjects (P &lt; 0.05).	Creatinine	88-98	aquaporin 2	Homo sapiens	21-26
15117607-15	2004	Levels of urinary beta 2-microglobulin in AP on days 1 to 3 postadmission were: 9.7 (1.1-93.3), 27.6 (4.7-421.4) and 88.3 (7.3-415.2) microg/mg of creatinine, respectively.	Creatinine	147-157	beta-2-microglobulin	Homo sapiens	18-38
15110131-3	2004	OBJECTIVE: The present study was designed to assess teh pharmacokinetic and pharmacodynamic properties of eptifibatide in subjects with various levels of creatinine clearance (CrCl), a parameter that is a more accurate indicator of renal function than serum creatinine concentration to determine the appropriate dose adjustment in patients with reduced renal function.	Creatinine	154-164	CRCL	Homo sapiens	176-180
15110131-3	2004	OBJECTIVE: The present study was designed to assess teh pharmacokinetic and pharmacodynamic properties of eptifibatide in subjects with various levels of creatinine clearance (CrCl), a parameter that is a more accurate indicator of renal function than serum creatinine concentration to determine the appropriate dose adjustment in patients with reduced renal function.	Creatinine	258-268	CRCL	Homo sapiens	176-180
14736958-10	2004	EPO-treated rats subjected to bilateral IR injury exhibited similar histological improvements to the unilateral IR injury model, as well as significantly lower peak plasma creatinine concentrations than their vehicle-treated controls (0.04+/-0.01 vs 0.21+/-0.08 mmol/l, respectively, P&lt;0.05).	Creatinine	172-182	erythropoietin	Rattus norvegicus	0-3
15007908-2	2004	We investigated the correlation between 24 H-UP and the protein/creatinine ratio of the first voided morning urine samples (MUP/Cr) and evaluated the problems associated with this method.	Creatinine	64-74	major urinary protein, pseudogene	Homo sapiens	124-127
15007908-5	2004	Although MUP/Cr correlated well with 24 H-UP, it was necessary to revise the estimation of 24 H-UP from MUP/Cr, which is lower in infants and young children because of age-related differences in creatinine excretion.	Creatinine	195-205	major urinary protein, pseudogene	Homo sapiens	104-107
14638545-3	2003	RI was defined as a calculated (Cockroft-Gault) creatinine clearance (CrCl) &lt; or =60 mL/min.	Creatinine	48-58	CRCL	Homo sapiens	70-74
14634689-8	2003	The main findings in the CHE2 C5+ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C(5) complex activity and creatinine (+), insulin (-) and WHR (-); a significantly higher frequency of weight loss occurred compared to the CHE2 C5- group.	Creatinine	172-182	butyrylcholinesterase	Homo sapiens	25-29
14638927-9	2003	Renal function at the first week posttransplantation (analyzed by serum creatinine levels) showed a significant correlation with both HO-1 and VEGF mRNA expression, reinforcing the protective role of both genes in the early events of transplantation.	Creatinine	72-82	heme oxygenase 1	Homo sapiens	134-138
14531820-16	2003	CONCLUSION: This study shows that (1) uPA and uPAR are up-regulated during acute renal allograft rejection; (2) uPAR levels in urine and serum correlate with serum creatinine levels, and (3) uPA and uPAR are produced by inflammatory cells, tubular epithelium, and vascular endothelium during acute renal allograft rejection.	Creatinine	164-174	plasminogen activator, urokinase receptor	Homo sapiens	112-116
14531820-16	2003	CONCLUSION: This study shows that (1) uPA and uPAR are up-regulated during acute renal allograft rejection; (2) uPAR levels in urine and serum correlate with serum creatinine levels, and (3) uPA and uPAR are produced by inflammatory cells, tubular epithelium, and vascular endothelium during acute renal allograft rejection.	Creatinine	164-174	plasminogen activator, urokinase receptor	Homo sapiens	112-116
12906034-7	2003	On univariate correlation analysis, leptin showed the strongest association with BMI in both sexes and also correlated significantly with BMI, insulin, uric acid, glucose, total cholesterol, and triglycerides in males and BMI, insulin, uric acid, total cholesterol, apo B, and creatinine in females after adjustment for age and BMI.	Creatinine	277-287	leptin	Homo sapiens	36-42
12801357-6	2003	After 4 days GGT excretion increased to 803 +/- 238 U g-1 creatinine, control: 445 +/- 106 U g-1 creatinine (P &lt; 0.05).	Creatinine	58-68	gamma-glutamyltransferase 1	Rattus norvegicus	13-16
12801357-6	2003	After 4 days GGT excretion increased to 803 +/- 238 U g-1 creatinine, control: 445 +/- 106 U g-1 creatinine (P &lt; 0.05).	Creatinine	97-107	gamma-glutamyltransferase 1	Rattus norvegicus	13-16
12631357-11	2003	A 24-hour urinary excretion of AQP-2 was significantly elevated in patients with CHF (median, 25.7 nmol/mol creatinine) compared to healthy controls (15.7 nmol/mol creatinine) and those with liver cirrhosis (17 nmol/mol creatinine).	Creatinine	108-118	aquaporin 2	Homo sapiens	31-36
12631357-11	2003	A 24-hour urinary excretion of AQP-2 was significantly elevated in patients with CHF (median, 25.7 nmol/mol creatinine) compared to healthy controls (15.7 nmol/mol creatinine) and those with liver cirrhosis (17 nmol/mol creatinine).	Creatinine	164-174	aquaporin 2	Homo sapiens	31-36
12631357-11	2003	A 24-hour urinary excretion of AQP-2 was significantly elevated in patients with CHF (median, 25.7 nmol/mol creatinine) compared to healthy controls (15.7 nmol/mol creatinine) and those with liver cirrhosis (17 nmol/mol creatinine).	Creatinine	164-174	aquaporin 2	Homo sapiens	31-36
12545001-10	2003	ACR was associated with intensive care unit stay (p =.0021) and highest serum C-reactive protein (p =.0002), serum creatinine (p &lt;.0001), and bilirubin (p =.0009).	Creatinine	115-125	acrosin	Homo sapiens	0-3
12505750-5	2003	The median urinary excretion level of MCP-1 in patients with macroalbuminuria (394.4 ng/g creatinine) was significantly elevated compared to the levels in patients with normoalbuminuria and microalbuminuria (159.6 and 193.9 ng/g creatinine, respectively).	Creatinine	90-100	C-C motif chemokine ligand 2	Homo sapiens	38-43
12505750-5	2003	The median urinary excretion level of MCP-1 in patients with macroalbuminuria (394.4 ng/g creatinine) was significantly elevated compared to the levels in patients with normoalbuminuria and microalbuminuria (159.6 and 193.9 ng/g creatinine, respectively).	Creatinine	229-239	C-C motif chemokine ligand 2	Homo sapiens	38-43
12518171-2	2003	We have previously reported that after 8 weeks of oral therapy with H1-A, 40 microg/kg/day, MRL lpr/lpr mice demonstrated significantly less proteinuria, lower serum creatinine levels, and less renal mesangial proliferation than mice in an untreated group.	Creatinine	166-176	H1.1 linker histone, cluster member	Mus musculus	68-72
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	thrombomodulin	Homo sapiens	187-201
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	Creatinine	33-43	thrombomodulin	Homo sapiens	203-205
12484510-5	2002	The age, sex, duration of diabetes, levels of blood pressure and blood glucose and rates of creatinine clearance (CrCl) were compared between 36 diabetic patients with LVH and 36 matched diabetic patients without LVH.	Creatinine	92-102	CRCL	Homo sapiens	114-118
12397045-6	2002	The plasma C-IR, but not N-IR, was significantly correlated with the serum creatinine level and was increased 2.8-fold in patients with end-stage renal disease compared with those in patients with normal renal function.	Creatinine	75-85	corepressor interacting with RBPJ, CIR1	Homo sapiens	11-15
12073198-8	2002	MEASUREMENTS AND MAIN RESULTS: Five patients (63%) showed a postoperative elevation of serum creatinine (median increase from baseline, 35.4%; range, 8.3% to 50.6%) that was associated with significant elevations of urinary microalbumin-to-creatinine, alpha-GST-to-creatinine, and pi-GST-to-creatinine ratios soon after clamp removal.	Creatinine	93-103	glutathione S-transferase kappa 1	Homo sapiens	258-261
12073198-8	2002	MEASUREMENTS AND MAIN RESULTS: Five patients (63%) showed a postoperative elevation of serum creatinine (median increase from baseline, 35.4%; range, 8.3% to 50.6%) that was associated with significant elevations of urinary microalbumin-to-creatinine, alpha-GST-to-creatinine, and pi-GST-to-creatinine ratios soon after clamp removal.	Creatinine	93-103	glutathione S-transferase kappa 1	Homo sapiens	284-287
12073198-11	2002	The peak levels of GST enzymes were significantly (r(2) &gt; 80%) associated with the percent increase in serum creatinine from baseline.	Creatinine	112-122	glutathione S-transferase kappa 1	Homo sapiens	19-22
12073198-12	2002	CONCLUSION: Urinary GST-to-creatinine ratios are a sensitive early biomarker for renal injury after infrarenal abdominal aortic aneurysm repair.	Creatinine	27-37	glutathione S-transferase kappa 1	Homo sapiens	20-23
12053053-4	2002	After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p &lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p &lt; 0.01).	Creatinine	90-100	aquaporin 2	Homo sapiens	32-38
12053066-0	2002	Creatinine inhibits D-amino acid oxidase.	Creatinine	0-10	D-amino acid oxidase	Homo sapiens	20-40
12053066-2	2002	Creatinine (CTN) was found to inhibit DAO at a similar concentration in the sera of uremic patients.	Creatinine	0-10	D-amino acid oxidase	Homo sapiens	38-41
12053066-2	2002	Creatinine (CTN) was found to inhibit DAO at a similar concentration in the sera of uremic patients.	Creatinine	12-15	D-amino acid oxidase	Homo sapiens	38-41
12053066-4	2002	Moreover, CTN was shown to interact with flavin adenine dinucleotide (FAD), a coenzyme of DAO.	Creatinine	10-13	D-amino acid oxidase	Homo sapiens	90-93
12053066-5	2002	The UV spectral change of FAD bound to DAO was observed in the visible region by addition of CTN.	Creatinine	93-96	D-amino acid oxidase	Homo sapiens	39-42
11840382-10	2002	The percent increase in the beta2MG-to-Cr ratio in group 2 relative to that in group 1 was the highest, followed by percent increases in the NAG-to-Cr, TP-to-Cr, Alb-to-Cr, UA-to-Cr, and UN-to-Cr ratios.	Creatinine	39-41	beta-2-microglobulin	Homo sapiens	28-35
11841836-10	2002	By the histological examination for synovial tissue of RA patients, TRX was shown to be present on the surface of synovial lining layer as well as in the leukocytes.Moreover, urinary excretion of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage by endogenously generated oxygen radicals, was significantly higher in RA patients than in healthy subjects (11.55 +/- 4.71 versus 7.76 +/- 2.26 ng/mg creatinine, P&lt;0.0001).	Creatinine	421-431	thioredoxin	Homo sapiens	68-71
11886172-11	2002	Two hours following revascularization, urinary IL-1ra correlated with urinary alpha(1)-microglobulin/creatinine ratios (P&lt;0.05).	Creatinine	101-111	interleukin 1 receptor antagonist	Homo sapiens	47-53
11886172-13	2002	The correlation between urinary IL-1ra and alpha(1)-microglobulin/creatinine ratios is consistent with earlier suggestions of a mechanistic link between cytokine changes and proximal tubular dysfunction.	Creatinine	66-76	interleukin 1 receptor antagonist	Homo sapiens	32-38
11049868-4	2000	Intraperitoneal administration of PARP inhibitors, benzamide or 3-amino benzamide, after I/R injury accelerates the recovery of normal renal function, as assessed by monitoring the levels of plasma creatinine and blood urea nitrogen during 6 days postischemia.	Creatinine	198-208	poly (ADP-ribose) polymerase 1	Rattus norvegicus	34-38
11057934-11	2000	hydration provided better protection against nephrotoxicity, oral hydration was relatively safe and convenient provided that creatinine clearance (CrCl) is monitored closely.	Creatinine	125-135	CRCL	Homo sapiens	147-151
10535393-9	1999	In both groups A and B, creatinine clearance was inversely correlated with the serum leptin level after adjusting for body fat.	Creatinine	24-34	leptin	Homo sapiens	85-91
10572396-4	1999	Urinary levels of MCAF/MCP-1 were significantly higher in patients with RPGN as compared with those of other renal diseases and healthy volunteers(21.8 +/- 4.5 vs. 11.6 +/- 3.5, 1.0 +/- 0.1 pg/ml creatinine, respectively, p &lt; 0.01, mean +/- SEM).	Creatinine	196-206	C-C motif chemokine ligand 2	Homo sapiens	18-22
10572396-4	1999	Urinary levels of MCAF/MCP-1 were significantly higher in patients with RPGN as compared with those of other renal diseases and healthy volunteers(21.8 +/- 4.5 vs. 11.6 +/- 3.5, 1.0 +/- 0.1 pg/ml creatinine, respectively, p &lt; 0.01, mean +/- SEM).	Creatinine	196-206	C-C motif chemokine ligand 2	Homo sapiens	23-28
10552152-8	1999	Serum beta2-mi was found to be increased to values of over 2.7 mg/l in 4 UBC and 12 UTUC patients with normal serum creatinine levels.	Creatinine	116-126	beta-2-microglobulin	Homo sapiens	6-14
10475326-2	1999	However, no studies have determined the influence of renal function (as assessed by creatinine clearance [CrCl]) on its pharmacokinetics in patients without renal failure.	Creatinine	84-94	CRCL	Homo sapiens	106-110
10520002-4	1999	36, P = 0.002), whereas beta2m, in addition to BMPC% (r = 0.43, P = 0.0003), also correlated with creatinine levels (r = 0.63, P &lt; 0.0001), haemoglobin levels (r = -0.35, P = 0.0007) and patient age (r = 0.34, P &lt; 0.0011).	Creatinine	98-108	beta-2-microglobulin	Homo sapiens	24-30
10446112-8	1999	Serum MCP-1 concentrations correlated significantly with serum aspartate aminotransferase and creatinine.	Creatinine	94-104	C-C motif chemokine ligand 2	Homo sapiens	6-11
9879598-4	1998	The purpose of the study was to estimate urine cathepsin B, collagenase activity and urine excretion of TGF-beta 1 and fibronectin in MG. Cathepsin B activity was greater in the urine of MG patients than in the control group (10.58 +/- 8.73 pmol AMC/mg creatinine per min-1 vs control 7.11 +/- 2.05 pmol AMC/mg creatinine per min-1; P &lt; 0.05).	Creatinine	253-263	cathepsin B	Homo sapiens	138-149
9859901-8	1998	The highest mean BLP levels were documented in BPD infants under age 3 months (882 fmol/mg creatinine), in controls between 3 and 12 months of age (625 fmol/mg creatinine), and in 12-60-month-old CF subjects (486 fmol/mg creatinine).	Creatinine	91-101	dynein light chain roadblock-type 1	Homo sapiens	17-20
9859901-8	1998	The highest mean BLP levels were documented in BPD infants under age 3 months (882 fmol/mg creatinine), in controls between 3 and 12 months of age (625 fmol/mg creatinine), and in 12-60-month-old CF subjects (486 fmol/mg creatinine).	Creatinine	160-170	dynein light chain roadblock-type 1	Homo sapiens	17-20
9859901-8	1998	The highest mean BLP levels were documented in BPD infants under age 3 months (882 fmol/mg creatinine), in controls between 3 and 12 months of age (625 fmol/mg creatinine), and in 12-60-month-old CF subjects (486 fmol/mg creatinine).	Creatinine	160-170	dynein light chain roadblock-type 1	Homo sapiens	17-20
9922985-8	1998	Conversely, a significant negative correlation was found between VDR and serum creatinine values when A-CRF and M-CRF were considered altogether (r = -0.63; p &lt; 0.01).	Creatinine	79-89	vitamin D receptor	Homo sapiens	65-68
9674342-6	1998	The SAA levels also increased along with those of serum creatinine levels.	Creatinine	56-66	serum amyloid A1 cluster	Homo sapiens	4-7
9440085-5	1998	Clusterin mRNA was positively correlated with urinary protein excretion and negatively correlated with creatinine clearance in Zucker rats.	Creatinine	103-113	clusterin	Rattus norvegicus	0-9
9557072-6	1997	We aimed to estimate urine cathepsin B, collagenase activity and urine excretion of TGF-beta 1 and fibronectin in MG. MG patients revealed increased urine cathepsin B activity (10.58 +/- 8.73 pmol AMC/mg creatinine/min.	Creatinine	204-214	cathepsin B	Homo sapiens	155-166
9285144-6	1997	In healthy controls mean urinary ICAM-1/cr was 2.5 +/- 3.0 ng/mg creatinine and differed significantly from that of patients (14.5 +/- 14.9 ng/mg) (p &lt; 0.005).	Creatinine	65-75	intercellular adhesion molecule 1	Homo sapiens	33-39
9183492-7	1997	In premature infants there was a significant positive correlation between A1M:creatinine ratio and RBP:creatinine ratio (r = 0.85), and also between albumin and both A1M and RBP (r = 0.82 and 0.77).	Creatinine	78-88	retinol binding protein 4	Homo sapiens	99-102
9176853-3	1997	Significant correlations were observed between the urinary protein level and the mRNA level of PDGF-beta receptor expression and PDGF B-chain expression, and between the serum creatinine level and the mRNA level of PDGF-beta receptor expression.	Creatinine	176-186	platelet derived growth factor subunit B	Homo sapiens	215-224
9048347-11	1997	It was concluded that GFR estimated by serum creatinine is superior to outpatient 24-h urine creatinine clearance in this population.	Creatinine	45-55	Rap guanine nucleotide exchange factor 5	Homo sapiens	22-25
9048347-12	1997	Serum creatinine values can be used to provide a reasonably accurate estimate of GFR in hypertensive African Americans.	Creatinine	6-16	Rap guanine nucleotide exchange factor 5	Homo sapiens	81-84
9048350-6	1997	Marked induction of clusterin mRNA was seen only at 5 days, a time when serum creatinine concentration was the highest.	Creatinine	78-88	clusterin	Rattus norvegicus	20-29
8946001-3	1996	Serum creatinine (mg/ dl) 24 h following renal ischemia was 1.58 +/- 0.17 in the PAF antagonist-treated rats compared with 2.19 +/- 0.15 in rats given placebo (P &lt; 0.01).	Creatinine	6-16	PCNA clamp associated factor	Rattus norvegicus	81-84
8743538-7	1996	Intravenously-administered CNP exerted significant diuretic (% increase: +117 +/- 85.0), natriuretic, kalliuretic and chloriuretic actions with the increase of endogenous creatinine clearance.	Creatinine	171-181	natriuretic peptide C	Homo sapiens	27-30
8744465-1	1996	The abilities of a modified Cockcroft-Gault equation and the standard equation to estimate creatinine clearance (CLcr) in trauma patients were compared.	Creatinine	91-101	chymotrypsin C	Homo sapiens	113-117
8744465-3	1996	Creatinine concentrations in urine and serum were used to calculate the actual CLcr, which was normalized to 1.73 sq m. CLcr was estimated by the modified equation (which normalized body weight to 72 kg) and by the standard equation using ABW, IBW, and dosing body weight (DBW).	Creatinine	0-10	chymotrypsin C	Homo sapiens	79-83
8723446-8	1996	The NPEM-OSS4 model was described by the equations kel = 0.06516+ (0.00708.CLCR) and V1 = 0.1773 +/- 0.0406 liter/kg where CLCR is creatinine clearance in milliliters per minute per 1.73 m2, V1 is the volume of distribution of the central compartment, and kel is the elimination rate constant.	Creatinine	131-141	chymotrypsin C	Homo sapiens	123-127
8624314-1	1996	OBJECTIVE: To assess the measurement of inactive urinary kallikrein (IUK) to creatinine (Cr) ratio (IUK:Cr) on an untimed urine sample, collected between 16 and 20 weeks of pregnancy, as a predictive test for the development of both proteinuric and nonproteinuric pre-eclampsia.	Creatinine	104-106	kallikrein related peptidase 4	Homo sapiens	57-67
8861797-7	1996	A fall in serum creatinine (-7 + or - 9%, Ns) paralleled the rise in GFR (r = -0.76, p &lt;0.01), but there was a further decrease of creatinine in the second to fourth week after conversion.	Creatinine	16-26	Rap guanine nucleotide exchange factor 5	Homo sapiens	69-72
8861799-2	1996	Since fingernail creatinine (Ncr) reflects serum creatinine at the time of nail formation, it has been suggested that the level of Ncr at the distal tip of the fingernail might represent the level of the serum creatinine about four months previously.	Creatinine	17-27	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	29-32
8861799-5	1996	The correlation between Ncr and the serum creatinine level obtained four months previously was highly significant (r = 0.895, p &lt;0.01).	Creatinine	42-52	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	24-27
8613263-6	1996	The antidiuretic effect of Ang-(1-7) in water-loaded rats was associated with a reduction of creatinine clearance (0.68 +/- 0.04 versus 1.38 +/- 0.32 mL/min in vehicle-treated rats, P &lt;.05) and an increase in urine osmolality (266.8 +/- 32.7 versus 182.8 +/- 14 mOsm/kg in vehicle-treated rats, P &lt;.05).	Creatinine	93-103	angiogenin	Rattus norvegicus	27-35
17177827-4	1996	Compared with the phosphate-buffered saline solution-treated group, rats in the acidic fibroblast growth factor-treated group had significantly lower blood urea nitrogen (83.13 +/- 26.07 versus 176.36 +/- 62.36, p &lt; 0.05) and serum creatinine (0.73 +/- 0.14 versus 1.14 +/- 0.36, p &lt; 0.05) levels 1 day after occlusion.	Creatinine	235-245	fibroblast growth factor 1	Rattus norvegicus	80-111
7584932-7	1995	ANP also increased sodium excretion, creatinine clearance, and urine flow.	Creatinine	37-47	natriuretic peptide A	Rattus norvegicus	0-3
7559103-3	1995	The highest incidence of IR-hCG beta was obtained in the assay for beta-CF in the urine, with positive rates of 47.7% (94 of 197) for cervical, 37.8% (14 of 37) for endometrial, and 84.4% (38 of 45) for ovarian cancers with a cut-off value of 0.2 ng/mg of creatinine.	Creatinine	256-266	chorionic gonadotropin subunit beta 3	Homo sapiens	28-36
8519911-5	1995	In the remaining 26 dogs having detectable plasma EPO, the plasma concentration rate of EPO related to blood urea nitrogen and serum creatinine values.	Creatinine	133-143	erythropoietin	Canis lupus familiaris	88-91
7791430-2	1995	The simple 2-step method involves: (1) estimating creatinine clearance (CLcr) from age, sex, and serum creatinine, and (2) calculating the adjusted dose or dosing interval with the use of multipliers.	Creatinine	50-60	chymotrypsin C	Homo sapiens	72-76
7791430-2	1995	The simple 2-step method involves: (1) estimating creatinine clearance (CLcr) from age, sex, and serum creatinine, and (2) calculating the adjusted dose or dosing interval with the use of multipliers.	Creatinine	103-113	chymotrypsin C	Homo sapiens	72-76
7541576-10	1995	Serum creatinine correlated significantly with c-ICAM-1 and cVCAM-1 R = 0.30 and R = 0.22), but not with cE-selectin.	Creatinine	6-16	intercellular adhesion molecule 1	Homo sapiens	49-55
7779111-4	1995	Mean serum creatinine (mg/dl) 24 hours after ischemia was significantly decreased in the anti-ICAM-1 group (1.38 +/- 0.23, p &lt; 0.001) compared to control (2.87 +/- 0.34).	Creatinine	11-21	intercellular adhesion molecule 1	Rattus norvegicus	94-100
7579052-4	1995	Baseline characteristics that predicted a faster rate of decline in GFR in persons with ADPKD were greater serum creatinine (independent of GFR), greater urinary protein excretion, higher mean arterial pressure (MAP), and younger age.	Creatinine	113-123	Rap guanine nucleotide exchange factor 5	Homo sapiens	68-71
7875651-5	1994	Maximal Ca2+ ATPase activity was significantly correlated to creatinine clearance in non-insulin-dependent diabetes mellitus, but not in insulin-dependent diabetes mellitus.	Creatinine	61-71	carbonic anhydrase 2	Homo sapiens	8-19
7979097-6	1994	The median RBP/Cr ratio was higher in those patients exhibiting biochemical hepatotoxicity compared with those without hepatotoxicity, in whom median RBP/Cr was not significantly higher than controls.	Creatinine	15-17	retinol binding protein 4	Homo sapiens	11-14
7979097-7	1994	Within the group of patients showing biochemical hepatotoxicity, there was a correlation between log RBP/Cr and TmPO4/GFR.	Creatinine	105-107	retinol binding protein 4	Homo sapiens	101-104
8023133-2	1994	The mean levels of the Hg (U-Hg) were 0.43 and 0.34 micrograms Hg/g creatinine in lowlanders and in highlanders, respectively, which did not suggest existence of high-level exposure to Hg in these populations.	Creatinine	68-78	small nucleolar RNA host gene 1	Homo sapiens	27-31
8072258-8	1994	In patients with FSGS on RB1 and RB2, serum creatinine at the end of CsA treatment was 130.6 +/- 60.1 mumol/liter, significantly greater (P = 0.022) than the corresponding levels in the subset with MCD (87.3 +/- 24.8).	Creatinine	44-54	RB transcriptional corepressor like 2	Homo sapiens	33-36
8084448-6	1994	There was a positive correlation between urinary RBP and 24-h proteinuria (r = 0.40, P &lt; 0.01), and an inverse correlation between urinary RBP and creatinine clearance (r = -0.60, P &lt; 0.01).	Creatinine	150-160	retinol binding protein 4	Homo sapiens	142-145
8084448-7	1994	In a multivariate analysis adjusting for duration of disease, blood pressure, 24-h proteinuria, and creatinine clearance, mean urinary RBP continued to be significantly and progressively greater for patients with no renal disease, stable renal disease, probably active and active nephritis.	Creatinine	100-110	retinol binding protein 4	Homo sapiens	135-138
7910667-5	1994	The cumulative change in RBP excretion was related to plasma creatinine concentrations following cis-platin administration.	Creatinine	61-71	retinol binding protein 4	Homo sapiens	25-28
8093798-0	1993	Creatinine clearance with cimetidine for measurement of GFR.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	56-59
8093800-0	1993	Creatinine clearance with cimetidine for measurement of GFR.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	56-59
8093802-0	1993	Creatinine clearance with cimetidine for measurement of GFR.	Creatinine	0-10	Rap guanine nucleotide exchange factor 5	Homo sapiens	56-59
8268144-1	1993	BACKGROUND: Although endogenous creatinine clearance is often used as an indicator for the glomerular filtration rate (GFR), it may result in an overestimation due to its tubular secretion.	Creatinine	32-42	Rap guanine nucleotide exchange factor 5	Homo sapiens	119-122
8268144-2	1993	Since cimetidine is known to inhibit tubular secretion of creatinine, it may improve the accuracy of the creatinine clearance in measuring GFR.	Creatinine	58-68	Rap guanine nucleotide exchange factor 5	Homo sapiens	139-142
8268144-2	1993	Since cimetidine is known to inhibit tubular secretion of creatinine, it may improve the accuracy of the creatinine clearance in measuring GFR.	Creatinine	105-115	Rap guanine nucleotide exchange factor 5	Homo sapiens	139-142
8164618-4	1993	We found a positive correlation between the percentage of decrease, with respect to basal values, of TRAP and OH-Prol/creatinine (p &lt; 0.05).	Creatinine	118-128	acid phosphatase 5, tartrate resistant	Rattus norvegicus	101-105
8381929-8	1993	Our data suggests that this early hypertension is closely associated with mild impairment of GFR, occurring within the accepted normal range for serum creatinine.	Creatinine	151-161	Rap guanine nucleotide exchange factor 5	Homo sapiens	93-96
8390011-10	1993	Circulating GH and GH-BP activity were influenced by serum creatinine and haematocrit.	Creatinine	59-69	growth hormone receptor	Homo sapiens	19-24
1429995-4	1992	The creatinine-containing fraction was switched to a reversed-phase Shandon RP18 column and was focused there by alteration of the eluent from pH 6.5 to phosphoric acid-ion-pair reagent.	Creatinine	4-14	pre-mRNA processing factor 3	Homo sapiens	76-80
1415055-5	1992	MEASUREMENTS: The Cr-GFR was calculated by means of the formula GFR (milliliters per minute per 1.73 m2) = kL/serum creatinine (milligrams per deciliter), where L is body length in centimeters and k is a constant dependent on age and sex.	Creatinine	116-126	Rap guanine nucleotide exchange factor 5	Homo sapiens	21-24
1415055-5	1992	MEASUREMENTS: The Cr-GFR was calculated by means of the formula GFR (milliliters per minute per 1.73 m2) = kL/serum creatinine (milligrams per deciliter), where L is body length in centimeters and k is a constant dependent on age and sex.	Creatinine	116-126	Rap guanine nucleotide exchange factor 5	Homo sapiens	64-67
1363243-8	1992	Urinary gamma-GTP activity in the patients did not differ from that in the controls, but urinary NAG/gamma-GTP ratio was higher in the patients, and reversely correlated with creatinine clearance (r = -0.721; p &lt; 0.01).	Creatinine	175-185	inactive glutathione hydrolase 2	Homo sapiens	101-110
1356185-3	1992	DREM is a two-step process: Cockcroft and Gault estimation of creatinine clearance (CLcr) from age, sex, and serum creatinine and calculation of the adjusted dose or dosing interval by multipliers.	Creatinine	62-72	chymotrypsin C	Homo sapiens	84-88
1356185-3	1992	DREM is a two-step process: Cockcroft and Gault estimation of creatinine clearance (CLcr) from age, sex, and serum creatinine and calculation of the adjusted dose or dosing interval by multipliers.	Creatinine	115-125	chymotrypsin C	Homo sapiens	84-88
1386156-6	1992	A68828 alone, A68828 with dopamine, or ANF[1-28] infusion attenuated the rise in plasma creatinine levels by approximately 50% on each day of the study; dopamine alone was no different from vehicle-treated controls.	Creatinine	88-98	natriuretic peptide A	Rattus norvegicus	39-42
1783855-8	1991	Side effects were common in patients receiving Cs-A [5 mgm/kg/day (or greater)], with hypertension, tremor, hirsutism and raised serum creatinine being most frequent.	Creatinine	135-145	chorionic somatomammotropin hormone 1	Homo sapiens	47-51
1921737-3	1991	The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine.	Creatinine	128-138	cystatin 12, pseudogene	Homo sapiens	27-43
1921737-3	1991	The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine.	Creatinine	151-161	cystatin 12, pseudogene	Homo sapiens	27-43
1906396-3	1991	Throughout the whole period a correlation (r = -0.65, P less than 0.05) was found between the CD4+/CD8+ ratio and serum, creatinine.	Creatinine	121-131	CD8a molecule	Homo sapiens	99-102
1825077-3	1991	Levels of h-ANF were raised only in patients with evidence of severe renal impairment (serum creatinine greater than 300 mumol/l and urine output less than 100 ml/24 hours).	Creatinine	93-103	HESX homeobox 1	Homo sapiens	10-15
2073770-8	1990	S-creatinine levels were directly correlated with Chol/P ratio in group 1 and indirectly with Lin/Ol ratio and PUFA in group 2.	Creatinine	2-12	pumilio RNA binding family member 3	Homo sapiens	111-115
1963646-4	1990	Treatment with the PAF receptor antagonist L659,989 for four weeks, starting at 12 weeks of age, significantly reduced acute glomerular infiltration and proliferation, and prevented chronic glomerular histological changes; proteinuria and serum creatinine levels were also significantly reduced in treated mice.	Creatinine	245-255	platelet-activating factor receptor	Mus musculus	19-31
2150015-2	1990	Median urinary NAG for twenty reference individuals was 0.26 U/mmol creatinine and NAG B was 24%.	Creatinine	68-78	NBAS subunit of NRZ tethering complex	Homo sapiens	15-18
2242568-5	1990	Partially characterized peaks P1 and P2, obtained by gel filtration, correlated with the concentration of creatinine in serum; their concentrations were significantly (P less than 0.01) larger in hemodialyzed groups than in peritoneal dialyzed or in nondialyzed azotemic patients.	Creatinine	106-116	crystallin gamma F, pseudogene	Homo sapiens	30-39
33944766-19	2021	CONCLUSIONS: Although both venous HCO3 and CK showed a weak correlation with creatinine, the former performed significantly better in predicting AKI.	Creatinine	77-87	cytidine/uridine monophosphate kinase 1	Homo sapiens	43-45
33771116-12	2021	Urinary NGAL excretion increased in both groups (DeltaNGAL: 5.5 [4.1; 11.7] mug/mmol creatinine p = 0.004 after IS vs. 5.5 [2.1;9.4] mug/mmol creatinine after PL, p < 0.001).	Creatinine	85-95	lipocalin 2	Homo sapiens	8-12
33771116-12	2021	Urinary NGAL excretion increased in both groups (DeltaNGAL: 5.5 [4.1; 11.7] mug/mmol creatinine p = 0.004 after IS vs. 5.5 [2.1;9.4] mug/mmol creatinine after PL, p < 0.001).	Creatinine	142-152	lipocalin 2	Homo sapiens	8-12
33771116-14	2021	Similarly, urinary KIM-1 excretion increased in both groups (DeltaKIM-1: IS 115.8 [74.1; 156.2] ng/mmol creatinine, p < 0.001 vs. PL 152.4 [120.1; 307.9] ng/mmol creatinine, p < 0.001).	Creatinine	104-114	hepatitis A virus cellular receptor 1	Homo sapiens	19-24
34595711-8	2022	Mean urinary levels were 189.2 mug/g-creatinine for tBPA and 27.8 mug/g-creatinine for fBPA, and the fBPA/tBPA ratio was 27.9%.	Creatinine	37-47	transthyretin	Homo sapiens	52-56
34822581-9	2021	NGAL levels upon admission are positively correlated with creatinine levels at 48 h in different stages of AKI.	Creatinine	58-68	lipocalin 2	Homo sapiens	0-4
34822581-11	2021	The quantification of NGAL can be recommended as a routine test in hospitals that treat snakebites to decide on RRT at early time points instead of waiting for 48 h to confirm the increase in creatinine levels.	Creatinine	192-202	lipocalin 2	Homo sapiens	22-26
34742257-11	2021	Over the entire range of measured creatinine values (<0.20mg/dL-8.4mg/dL), the correlation between the reference creatinine and adjusted and unadjusted point-of-care creatinine was high with R2 values of 0.95 and 0.93 respectively; however, the correlation was significantly lower in children with creatinine values <1mg/dL (R2 of 0.44 between the reference and adjusted and unadjusted i-STAT creatinine).	Creatinine	34-44	signal transducer and activator of transcription 1	Homo sapiens	388-392
34742257-11	2021	Over the entire range of measured creatinine values (<0.20mg/dL-8.4mg/dL), the correlation between the reference creatinine and adjusted and unadjusted point-of-care creatinine was high with R2 values of 0.95 and 0.93 respectively; however, the correlation was significantly lower in children with creatinine values <1mg/dL (R2 of 0.44 between the reference and adjusted and unadjusted i-STAT creatinine).	Creatinine	113-123	signal transducer and activator of transcription 1	Homo sapiens	388-392
34742257-11	2021	Over the entire range of measured creatinine values (<0.20mg/dL-8.4mg/dL), the correlation between the reference creatinine and adjusted and unadjusted point-of-care creatinine was high with R2 values of 0.95 and 0.93 respectively; however, the correlation was significantly lower in children with creatinine values <1mg/dL (R2 of 0.44 between the reference and adjusted and unadjusted i-STAT creatinine).	Creatinine	393-403	signal transducer and activator of transcription 1	Homo sapiens	388-392
34554658-0	2021	New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.	Creatinine	4-14	Rap guanine nucleotide exchange factor 5	Homo sapiens	59-62
34554658-6	2021	RESULTS: In the validation data set, the current creatinine equation that uses age, sex, and race overestimated measured GFR in Blacks (median, 3.7 ml per minute per 1.73 m2 of body-surface area; 95% confidence interval (CI), 1.8 to 5.4) and to a lesser degree in non-Blacks (median, 0.5 ml per minute per 1.73 m2; 95% CI, 0.0 to 0.9).	Creatinine	49-59	Rap guanine nucleotide exchange factor 5	Homo sapiens	121-124
34355651-0	2021	Diagnostic performance of kidney injury molecule-1 for detection of abnormal urinary albumin-to-creatinine ratio in type 2 diabetes mellitus.	Creatinine	96-106	hepatitis A virus cellular receptor 1	Homo sapiens	26-50
34859872-6	2021	Strong positive correlation was observed between urine albumin and urine albumin creatinine ratio (ACR), and strong negative correlations between urine creatinine and urine cystatin, and between urine creatinine with urine NGAL.	Creatinine	201-211	lipocalin 2	Homo sapiens	223-227
34171450-9	2021	IL-10 was negatively associated with BUN (r = -0.39,p = 0.07), creatinine (r = -0.35, p = 0.002), sodium (r = -0.45, p = 0.03), and potassium (r = -0.68, p = 0.003).	Creatinine	63-73	interleukin 10	Homo sapiens	0-5
34555645-8	2021	Positive correlation between creatinine with IFN-gamma, CCL-2/MCP-1, and CXCL-10/IP-10, and negative correlation with IL-10 was identified in patients with Kt/V < 1.2 (P < 0.05).	Creatinine	29-39	C-X-C motif chemokine ligand 10	Homo sapiens	73-80
34555645-8	2021	Positive correlation between creatinine with IFN-gamma, CCL-2/MCP-1, and CXCL-10/IP-10, and negative correlation with IL-10 was identified in patients with Kt/V < 1.2 (P < 0.05).	Creatinine	29-39	C-X-C motif chemokine ligand 10	Homo sapiens	81-86
34555645-9	2021	In patients with Kt/V >= 1.2, only IL-10 was positively and CXCL-10/IP-10 negatively correlated with creatinine levels (P < 0.05).	Creatinine	101-111	C-X-C motif chemokine ligand 10	Homo sapiens	68-73
34827108-4	2021	Serum biochemical examinations revealed that both the creatinine and blood urea nitrogen concentrations were significantly higher in the Vit D3-treated group.	Creatinine	54-64	vitrin	Mus musculus	137-140
34721589-7	2021	Compared with ADSCs, miR-20a-ADSC treatment significantly improved serologic and histologic abnormalities, as evidenced by reduced serum creatinine, anti-dsDNA antibody, 24 h urine protein levels, nephritis scores, and C3/IgG deposits.	Creatinine	137-147	microRNA 20a	Mus musculus	21-28
34707728-5	2021	Results: Among the examined variables, only the fraction of CD8+ TCM cells during the first observation was significantly correlated with the change rate in the D/P creatinine ratio (beta=1.47, P=0.001, adjusted R2=0.379).	Creatinine	165-175	CD8a molecule	Homo sapiens	60-63
34707728-6	2021	The CD8+ naive T and CD8+ TCM cell fractions were negatively correlated with the change rate of the D/P creatinine ratio (naive T cells: beta=-0.058, P=0.022, adjusted R2=0.188; TCM cells: beta=-0.096, P=0.046, adjusted R2=0.137).	Creatinine	104-114	CD8a molecule	Homo sapiens	4-7
34707728-6	2021	The CD8+ naive T and CD8+ TCM cell fractions were negatively correlated with the change rate of the D/P creatinine ratio (naive T cells: beta=-0.058, P=0.022, adjusted R2=0.188; TCM cells: beta=-0.096, P=0.046, adjusted R2=0.137).	Creatinine	104-114	CD8a molecule	Homo sapiens	21-24
34707728-7	2021	In addition, the change rates of the D/P creatinine ratio tended to be higher, though not significantly (one way ANOVA; P=0.080), in accordance with the increase in the change rate of the CD8+ effector memory T cells (TEM).	Creatinine	41-51	CD8a molecule	Homo sapiens	188-191
34440258-9	2021	In multivariate Cox analysis, miR-122-5p (HR = 1.0006, 95%CI = 1.0001-1.0011) and peripheral artery disease (PAD) (HR = 2.16, 95%CI = 1.26-3.70) were associated with CVD/MI/IS risk; miR-1-3p (HR = 2.73, 95%CI = 1.22-6.12) and PAD (HR = 3.47, 95%CI = 1.88-6.41) with CVD; miR-122-5p (HR = 1.0001, 95%CI = 1.000-1.0002) and creatinine level (HR = 1.02, 95%CI = 1.01-1.04) with IS, and miR-16-5p (HR = 1.0004, 95%CI = 1.0001-1.0008) with MI.	Creatinine	322-332	microRNA 122	Homo sapiens	30-37
34336828-12	2021	Wild-type mice treated with CCl4 developed significant multi-organ injury (increased ALT, creatinine, and brain water) upon LPS injection, and showed increased hepatic GSDMD cleavage compared to mice treated with CCl4 alone.	Creatinine	90-100	chemokine (C-C motif) ligand 4	Mus musculus	28-32
34142794-3	2021	Herein, we report a new sensor, a reduced graphene oxide stabilized binary copper-iron oxide-based nanocomposite on a 3D printed Ag-electrode (Fe-Cu-rGO@Ag) for detecting a wide range of blood creatinine (0.01 to 1000 muM; detection limit 10 nM) in an electrochemical chip with a current density ranging between 0.185 and 1.371 mA/cm2 and sensitivity limit of 1.1 muA muM-1 cm-2 at physiological pH.	Creatinine	193-203	PWWP domain containing 3A, DNA repair factor	Homo sapiens	368-373
34246297-9	2021	Five of those miRNAs (hsa-miR-126-3p, hsa-miR-142-3p, hsa-miR-146a-5p, hsa-miR-155-5p, and hsa-miR-222-3p) also had a positive correlation with serum creatinine and therefore a negative correlation with eGFR.	Creatinine	150-160	microRNA 155	Homo sapiens	71-82
34242326-8	2021	Regarding laboratory data, adiponectin level was associated with creatinine, and chemerin level was associated with creatinine, albumin, and erythrocyte sedimentation rate (ESR).	Creatinine	116-126	retinoic acid receptor responder 2	Homo sapiens	81-89
35635326-6	2022	KIM-1 and MCP-1 were standardized by urinary creatinine.	Creatinine	45-55	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
35527512-3	2022	Therefore, the objective of this study was to develop PBPK models of the endogenous organic cation transporter (OCT) 2 and multidrug and toxin extrusion protein (MATE) 1 substrates creatinine and N1 -methylnicotinamide (NMN).	Creatinine	181-191	solute carrier family 47 member 1	Homo sapiens	123-169
35501411-9	2022	The AKI Risk Score (AKI-RiSc) was a summation of the integer scores of 6 variables: serum creatinine, serum bicarbonate, pulse, systolic blood pressure, diastolic blood pressure, and age.	Creatinine	90-100	serine carboxypeptidase 1	Homo sapiens	24-28
35039910-9	2022	Of the 10 biomarkers suitable for HSROC analysis, urinary neutrophil gelatinase-associated lipocalin (uNGAL) to creatinine (Cr) ratio yielded the highest diagnostic odds ratio (91.0, 95% CI 90.1-91.9), with a sensitivity of 91.3% (95% CI 91.2-91.3%) and a specificity of 89.7% (95% CI 89.6-89.7%).	Creatinine	124-126	lipocalin 2	Homo sapiens	58-100
35277788-6	2022	Positive correlations were found between IL-1beta and fasting blood sugar and between creatinine levels and IL-17, HbA1c%, and sodium levels.	Creatinine	86-96	interleukin 17A	Homo sapiens	108-113
35547005-9	2022	Furthermore, serum LCN-2 levels were positively correlated with hemoglobin A1c, systolic blood pressure, hypertension, CAP, and DN, as well as renal function factors including uric acid, creatinine, the estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio, respectively (P < 0.05), but negatively correlated with HDL-c (P < 0.05).	Creatinine	187-197	lipocalin 2	Homo sapiens	19-24
35547005-9	2022	Furthermore, serum LCN-2 levels were positively correlated with hemoglobin A1c, systolic blood pressure, hypertension, CAP, and DN, as well as renal function factors including uric acid, creatinine, the estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio, respectively (P < 0.05), but negatively correlated with HDL-c (P < 0.05).	Creatinine	264-274	lipocalin 2	Homo sapiens	19-24
35467153-11	2022	For centres with no access to cystatin C, a creatinine-based equation, eGFR (mL/min/1.73 m2) = 89.674 (height(m)/Scr(mg/dL)/2.7)0.579 ( 1.007male) (height(m)/1.4)0.187, was derived, with P30 and P15 73.60% and 49.20%, respectively.	Creatinine	44-54	thrombopoietin	Mus musculus	77-79
35625681-3	2022	In addition, the glomerular and tubular expression of Panx1 was examined in patients with type 2 diabetes mellitus (DM2) and the control group, and renal Panx1 expression was correlated with serum creatinine.	Creatinine	197-207	pannexin 1	Homo sapiens	154-159
35625681-14	2022	A significant positive correlation was found between Panx1 expression in glomeruli and serum creatinine only in diabetic patients and was not found in the nondiabetic group.	Creatinine	93-103	pannexin 1	Homo sapiens	53-58
35625671-10	2022	The expression levels of TNFalpha, IL-2, IL-4, IL-6, IL-8, and IL-10 were higher in patients treated with continuous renal replacement therapy (CRRT) (p < 0.05), and the levels of the maximum plasma creatinine and TNFalpha Spearman"s rank-order correlation coefficient (rho = 0.51, p < 0.05) and IL-8 (rho = 0.44, p < 0.05) correlated.	Creatinine	199-209	interleukin 10	Homo sapiens	63-68
35464092-13	2022	Finally, CCL2, FOS, JUN were manifested a meaningful association with proteinuria, glomerular filtration rate (GFR), and serum creatinine level.	Creatinine	127-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-18
35363774-8	2022	Moreover, CDH2 and MCP-1 mRNAs inversely correlated with creatinine (r = -0.370 and r = -0.361, p<0.001) and Alb/Cr ratio (r = -0.355 and r = -0.297, p<0.001).	Creatinine	57-67	cadherin 2	Homo sapiens	10-14
35441828-6	2022	The mean arterial pressure was similar between the WT and TIGAR KO mice, associated with a comparable increase in plasma creatinine level.	Creatinine	121-131	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	58-63
35349059-4	2022	Thus, this study was carried to investigate associations of serum klotho with blood and urine cadmium and lead in US adults aged 40-79 years across stages of eGFR-based kidney function and albuminuria defined as urinary albumin/creatinine ratio of > 30 mg/g creatinine.	Creatinine	228-238	klotho	Homo sapiens	66-72
35349059-4	2022	Thus, this study was carried to investigate associations of serum klotho with blood and urine cadmium and lead in US adults aged 40-79 years across stages of eGFR-based kidney function and albuminuria defined as urinary albumin/creatinine ratio of > 30 mg/g creatinine.	Creatinine	258-268	klotho	Homo sapiens	66-72
35331172-7	2022	Five out of the 10 metabolites were up-regulated in the anti-TPO antibodies positivity group, including D-Glucose, L-Glutamine, 3-Hydroxybutyric acid, Myo-Inositol, Creatinine.	Creatinine	165-175	thyroid peroxidase	Homo sapiens	61-64
35399943-8	2022	In patients with type 2 diabetes, serum VEGF-B level was positively correlated with triglyceride, serum creatinine and cystatin C while negatively correlated with HDL-C and eGFR.	Creatinine	104-114	vascular endothelial growth factor B	Homo sapiens	40-46
35315361-4	2022	MIOX-Tg mice had severe tubular lesions associated with increased serum creatinine and proteinuria.	Creatinine	72-82	myo-inositol oxygenase	Mus musculus	0-4
35305556-2	2022	The aims of this study were to track the 7-day time course of blood miRNAs in patients with sepsis treated with vancomycin, gentamicin, or a non-nephrotoxic antibiotic and miRNA associations with neutrophil gelatinase-associated lipokalin (NGAL), creatinine, procalcitonin, interleukin-6, and acute kidney injury (AKI) stage.	Creatinine	247-257	lipocalin 2	Homo sapiens	196-238
35370771-10	2022	After the competition, there was a significant correlation only between serum NGAL and creatinine, which was classified as strong and positive (r: 0.77; p < 0.05).	Creatinine	87-97	lipocalin 2	Homo sapiens	78-82
35363168-8	2022	Correlation analysis showed that serum VEGF-D was negatively correlated with estimated glomerular filtration rate but positively correlated with serum creatinine, urine albumin-to-creatinine ratio, and urine protein-to-creatinine ratio.	Creatinine	151-161	vascular endothelial growth factor D	Homo sapiens	39-45
35363168-8	2022	Correlation analysis showed that serum VEGF-D was negatively correlated with estimated glomerular filtration rate but positively correlated with serum creatinine, urine albumin-to-creatinine ratio, and urine protein-to-creatinine ratio.	Creatinine	180-190	vascular endothelial growth factor D	Homo sapiens	39-45
35363168-8	2022	Correlation analysis showed that serum VEGF-D was negatively correlated with estimated glomerular filtration rate but positively correlated with serum creatinine, urine albumin-to-creatinine ratio, and urine protein-to-creatinine ratio.	Creatinine	219-229	vascular endothelial growth factor D	Homo sapiens	39-45
35046841-10	2021	Urinary neutrophil gelatinase-associated lipocalin values were significantly greater over time (P < 0.001), and there was a main effect of sex with female urinary creatinine (UCr) greater than males at all three time points (P = 0.040).	Creatinine	163-173	lipocalin 2	Homo sapiens	8-50
35046888-9	2021	The T1DM participants with positive NGAL had higher age (p = 0.03), T1DM evolution (p = 0.03), and serum creatinine (p = 0.003) than negative NGAL.	Creatinine	105-115	lipocalin 2	Homo sapiens	36-40
35173546-5	2022	CD137-positive lymphatic vessels were involved in the development process of IgA nephropathy and positively correlated with serum creatinine, serum urea nitrogen, serum uric acid, and urinary 24 h total protein.	Creatinine	130-140	TNF receptor superfamily member 9	Homo sapiens	0-5
2571202-8	1989	Data obtained from two-color staining revealed an increase of IL-2 receptor expression on peripheral T cells of at least 10% from the postoperative baseline, which preceded the creatinine rise from allograft rejection in 13 of 13 animals.	Creatinine	177-187	interleukin-2	Macaca fascicularis	62-66
2675399-1	1989	For alterations in serum creatinine to reflect changes in GFR, urine creatinine excretion must remain constant.	Creatinine	25-35	Rap guanine nucleotide exchange factor 5	Homo sapiens	58-61
2675399-1	1989	For alterations in serum creatinine to reflect changes in GFR, urine creatinine excretion must remain constant.	Creatinine	69-79	Rap guanine nucleotide exchange factor 5	Homo sapiens	58-61
2675399-2	1989	Although serum creatinine is often used to monitor chronic changes in allograft GFR, creatinine excretion has not been systematically investigated in renal transplant recipients.	Creatinine	15-25	Rap guanine nucleotide exchange factor 5	Homo sapiens	80-83
2774590-2	1989	There was a significant correlation between creatinine clearance and NAG values for (r = -0.4820, p less than 0.01).	Creatinine	44-54	NBAS subunit of NRZ tethering complex	Homo sapiens	69-72
2758596-8	1989	The concentration of beta-microseminoprotein was correlated with that of creatinine in serum, suggesting that the protein is eliminated--at least partly--from the circulation by glomerular filtration.	Creatinine	73-83	microseminoprotein beta	Homo sapiens	21-44
2972583-9	1988	Plasma hANF was 742 +/- 227 pg/ml (mean +/- SEM) in patients with FRFC compared with 360 +/- 70 pg/ml in patients with liver disease and normal serum creatinine (p greater than 0.05) and 28 +/- 5.7 pg/ml in healthy volunteers (p less than 0.005 vs. FRFC and chronic liver disease, ascites, and normal serum creatinine).	Creatinine	150-160	HESX homeobox 1	Homo sapiens	7-11
2972583-9	1988	Plasma hANF was 742 +/- 227 pg/ml (mean +/- SEM) in patients with FRFC compared with 360 +/- 70 pg/ml in patients with liver disease and normal serum creatinine (p greater than 0.05) and 28 +/- 5.7 pg/ml in healthy volunteers (p less than 0.005 vs. FRFC and chronic liver disease, ascites, and normal serum creatinine).	Creatinine	307-317	HESX homeobox 1	Homo sapiens	7-11
3059027-1	1988	The clearance of creatinine has been shown to overestimate GFR in patients with renal disease and in kidney transplant recipients.	Creatinine	17-27	Rap guanine nucleotide exchange factor 5	Homo sapiens	59-62
3059027-6	1988	Furthermore, creatinine clearance overestimated GFR by 50% and by 68% in patients with renal disease and in renal transplant recipients, respectively.	Creatinine	13-23	Rap guanine nucleotide exchange factor 5	Homo sapiens	48-51
3190182-1	1988	The relationships between creatinine clearance (CLCR) and the pharmacokinetics of oral ciprofloxacin were characterized.	Creatinine	26-36	chymotrypsin C	Homo sapiens	48-52
3280169-4	1988	In patients, the concentration of free RBP and the percentage of free RBP in serum were on logarithmic scales inversely correlated with the endogenous creatinine clearance (r = -0.80 and -0.76) and increased in parallel with the serum creatinine (r = 0.67 and 0.66) and beta 2-microglobulin concentrations (beta 2-m, r = 0.76 and 0.89).	Creatinine	151-161	retinol binding protein 4	Homo sapiens	39-42
3280169-4	1988	In patients, the concentration of free RBP and the percentage of free RBP in serum were on logarithmic scales inversely correlated with the endogenous creatinine clearance (r = -0.80 and -0.76) and increased in parallel with the serum creatinine (r = 0.67 and 0.66) and beta 2-microglobulin concentrations (beta 2-m, r = 0.76 and 0.89).	Creatinine	151-161	retinol binding protein 4	Homo sapiens	70-73
3280169-4	1988	In patients, the concentration of free RBP and the percentage of free RBP in serum were on logarithmic scales inversely correlated with the endogenous creatinine clearance (r = -0.80 and -0.76) and increased in parallel with the serum creatinine (r = 0.67 and 0.66) and beta 2-microglobulin concentrations (beta 2-m, r = 0.76 and 0.89).	Creatinine	235-245	retinol binding protein 4	Homo sapiens	39-42
3280169-4	1988	In patients, the concentration of free RBP and the percentage of free RBP in serum were on logarithmic scales inversely correlated with the endogenous creatinine clearance (r = -0.80 and -0.76) and increased in parallel with the serum creatinine (r = 0.67 and 0.66) and beta 2-microglobulin concentrations (beta 2-m, r = 0.76 and 0.89).	Creatinine	235-245	retinol binding protein 4	Homo sapiens	70-73
3140082-7	1988	The two clearance values did not differ significantly, showing that creatinine can be safely used as a reliable marker for measuring GFR.	Creatinine	68-78	Rap guanine nucleotide exchange factor 5	Homo sapiens	133-136
3314477-7	1987	The mean THP concentrations in urine (micrograms of THP per milligrams of creatinine) were 29.9 and 91.4 micrograms/mg for patients and controls, respectively.	Creatinine	74-84	uromodulin	Homo sapiens	9-12
3729324-2	1986	The elimination half-life of carumonam increased with decreasing creatinine clearance (CLCR) from 1.7 h in group 1 to 11.3 h in group 4.	Creatinine	65-75	chymotrypsin C	Homo sapiens	87-91
3954325-4	1986	The mean N6-SAR urinary excretion value for normal adults was 4.09 mg/gm of creatinine with a standard deviation of 1.22.	Creatinine	76-86	sarcosine dehydrogenase	Homo sapiens	12-15
3019591-7	1986	Urinary kallikrein excretion was found to be modestly lower in hypertensives compared to normotensives (0.40 +/- 0.05 versus 0.55 +/- 0.06 mU/mg creatinine).	Creatinine	145-155	kallikrein related peptidase 4	Homo sapiens	8-18
3935994-8	1985	Hairbulb tyrosinase activity was 1.75 pmoles/120 min/hairbulb, hairbulb glutathione content 0.83 nmoles/hairbulb, and urine excretion of 5-S-cysteinyldopa 174.9 ng/mg creatinine.	Creatinine	167-177	tyrosinase	Homo sapiens	9-19
6980397-2	1982	We confirm that ADA deficient patients excrete markedly increased amounts of 2"-deoxyadenosine (582 +/- 363 versus normal of less than 0.1 nmoles/mg creatinine) and increased amounts of adenosine (29.4 +/- 5.7 versus normal of 4.12 +/- 1.0 nmoles/mg creatinine).	Creatinine	149-159	adenosine deaminase	Homo sapiens	16-19
6980397-2	1982	We confirm that ADA deficient patients excrete markedly increased amounts of 2"-deoxyadenosine (582 +/- 363 versus normal of less than 0.1 nmoles/mg creatinine) and increased amounts of adenosine (29.4 +/- 5.7 versus normal of 4.12 +/- 1.0 nmoles/mg creatinine).	Creatinine	250-260	adenosine deaminase	Homo sapiens	16-19
6980397-5	1982	Only ADA deficient patients excrete detectable amounts of 2"-O-methyladenosine (2.1 +/- 1.1 versus normal of less than 0.1 nmoles/ mg creatinine), whereas both normals and ADA deficient children excrete N6, 2"-O-dimethyladenosine and R-adenosine.	Creatinine	134-144	adenosine deaminase	Homo sapiens	5-8
6980397-6	1982	However, ADA deficient patients do excrete increased amounts of R-adenosine (5.5 +/- 1.0 versus normal of 1.4 +/- 0.4 nmoles/mg creatinine).	Creatinine	128-138	adenosine deaminase	Homo sapiens	9-12
6450345-6	1981	Both normal and elevated serum DHEA-S concentrations correlated well with total urinary 17-KS when corrected for creatinine (P &lt; .0005).	Creatinine	113-123	sulfotransferase family 2A member 1	Homo sapiens	31-37
1155517-4	1975	Amniotic fluid creatinine levels showed an estimated 5 to 6 per cent risk for RDS at levels we formerly thought to be safe (greater than or equal to 2.0 mg. per 100 ml.	Creatinine	15-25	peripherin 2	Homo sapiens	78-81
1155517-12	1975	The risk of RDS associated with creatinine concentration makes this test unacceptable in any case of elective delivery; however, it may be useful as a weighing factor in emergency situations where phospholipid analysis is unavailable.	Creatinine	32-42	peripherin 2	Homo sapiens	12-15
33980035-5	2021	In addition, upon high-fat diet intervention for 4 weeks, AAV-hLCAT administered LCAT-/- hamsters exhibited improved atherogenic lipoprotein profiles, lower urine protein/creatinine ratio, a significant increase in red blood cells and hemoglobin, thus eventually protecting against atherosclerotic development.	Creatinine	171-181	lecithin-cholesterol acyltransferase	Homo sapiens	62-67
33980035-5	2021	In addition, upon high-fat diet intervention for 4 weeks, AAV-hLCAT administered LCAT-/- hamsters exhibited improved atherogenic lipoprotein profiles, lower urine protein/creatinine ratio, a significant increase in red blood cells and hemoglobin, thus eventually protecting against atherosclerotic development.	Creatinine	171-181	lecithin-cholesterol acyltransferase	Homo sapiens	63-67
33979307-6	2021	At an optimal cutpoint of 244 mug/g creatinine, NGAL distinguished ATN (344 [132, 1,429] mug/g creatinine) from prerenal AKI (45 [0, 154] mug/g) or HRS (110 [50, 393] mug/g; P < 0.001), with a C statistic of 0.762 (95% confidence interval 0.682, 0.842).	Creatinine	36-46	lipocalin 2	Homo sapiens	48-52
33979307-6	2021	At an optimal cutpoint of 244 mug/g creatinine, NGAL distinguished ATN (344 [132, 1,429] mug/g creatinine) from prerenal AKI (45 [0, 154] mug/g) or HRS (110 [50, 393] mug/g; P < 0.001), with a C statistic of 0.762 (95% confidence interval 0.682, 0.842).	Creatinine	95-105	lipocalin 2	Homo sapiens	48-52
33782168-10	2021	The exosome markers CD9 and CD63 colocalized and immunoprecipitated selectively with distal nephron markers.Conclusions uEV concentration is highly correlated with urine creatinine, potentially replacing the need for uEV quantification to normalize spot urines.	Creatinine	170-180	CD9 molecule	Homo sapiens	20-23
32989831-5	2021	Tucatinib also inhibited OCT2- and MATE1-mediated transport of creatinine, with IC50 values of 0.107 and 0.0855 microM, respectively.	Creatinine	63-73	solute carrier family 47 member 1	Homo sapiens	35-40
32989831-11	2021	These data demonstrate that tucatinib inhibits OCT2- and MATE1/2-K-mediated tubular secretion of creatinine, which may manifest as mild SCr elevations that are not indicative of renal impairment.	Creatinine	97-107	solute carrier family 47 member 1	Homo sapiens	57-62
33731764-11	2021	Postmenstrual age (PMA) and creatinine clearance (CLcr) affected the clearance of vancomycin, and model evaluation confirmed the robustness of the final model.	Creatinine	28-38	chymotrypsin C	Homo sapiens	50-54
33726550-10	2022	A negative correlation between the peripheral frequency of CD14+CCR5+ and the creatinine levels was identified in the intradialytic exercise session.	Creatinine	78-88	C-C motif chemokine receptor 5	Homo sapiens	64-68
33705425-1	2021	BACKGROUND: This study was conducted to retrospectively assess the relationships between: rhabdomyolysis (quantified by creatine kinase (CK) activity) and kidney injury (quantified by serum creatinine concentration), sex, age, body temperature on admission, presence of seizures, and agitation or aggression in patients presenting to the Emergency Department with acute recreational drug toxicity.	Creatinine	190-200	cytidine/uridine monophosphate kinase 1	Homo sapiens	2-4
33705425-9	2021	There was a positive correlation between CK activity and creatinine concentration (correlation coefficient r = 0.71, p<0.0001).	Creatinine	57-67	cytidine/uridine monophosphate kinase 1	Homo sapiens	41-43
33739027-6	2021	The level of NDRG1/Cr was significantly associated with pathologic T stage (p < 0.001) and pathological grade (p < 0.001).	Creatinine	19-21	N-myc downstream regulated 1	Homo sapiens	13-18
33513294-7	2021	The derived elimination half-life was approximately 3.05 h. In the final model, baseline creatinine clearance, sex, and race (Asian vs non-Asian) were significant covariates for CL/F; significant covariates for V/F were age, sex, and body weight; baseline albumin and baseline Mayo score were not significant covariates.	Creatinine	89-99	crooked neck pre-mRNA splicing factor 1	Homo sapiens	178-182
33058037-14	2021	In multivariate linear regression analysis (variables: MBP, urea, creatinine, eGFR, ferritin, uric acid, CA-IMT) azurocidin was independently associated with urea (t:2.658; p = 0.010) and CA-IMT (t:2.464; p = 0.017).	Creatinine	66-76	azurocidin 1	Homo sapiens	113-123
32643269-1	2021	AIMS/INTRODUCTION: Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary albumin-to-creatinine ratio (ACR) and negatively associated with the estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.	Creatinine	170-180	TNF receptor superfamily member 1B	Homo sapiens	109-114
33520106-16	2021	Compared with normal rats, serum level of TNC in diabetic rats was significantly increased (P < 0.05), which was positively correlated with urea nitrogen and urinary creatinine (P < 0.05).	Creatinine	166-176	tenascin C	Rattus norvegicus	42-45
33488855-10	2021	We found a negative correlation between both the urinary netrin-1 concentration and urinary netrin-1 concentration after normalization for urinary creatinine and the birth weight.	Creatinine	147-157	netrin 1	Homo sapiens	57-65
33488855-10	2021	We found a negative correlation between both the urinary netrin-1 concentration and urinary netrin-1 concentration after normalization for urinary creatinine and the birth weight.	Creatinine	147-157	netrin 1	Homo sapiens	92-100
33389462-11	2021	In addition, BTK was positively correlated with 24-h urine protein, serum creatinine levels (r = 0.456 and 0.453, respectively, p < 0.001), and negatively correlated with serum albumin (r = 0.357, p < 0.05).	Creatinine	74-84	Bruton tyrosine kinase	Homo sapiens	13-16
32743932-8	2021	RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use.	Creatinine	99-109	fibroblast growth factor 23	Homo sapiens	40-45
33642514-2	2021	The pharmacist initially carried out therapeutic drug monitoring using an estimate of the creatinine clearance (CLcr) level, which was based on the serum creatinine (SCr) and serum cystatin-C (CysC) levels, but was ultimately unable to control the plasma VCM concentration.	Creatinine	90-100	chymotrypsin C	Homo sapiens	112-116
33642514-2	2021	The pharmacist initially carried out therapeutic drug monitoring using an estimate of the creatinine clearance (CLcr) level, which was based on the serum creatinine (SCr) and serum cystatin-C (CysC) levels, but was ultimately unable to control the plasma VCM concentration.	Creatinine	154-164	chymotrypsin C	Homo sapiens	112-116
32841436-5	2020	Urine-values of NAG and KIM-1 got related to urinary creatinine.	Creatinine	53-63	hepatitis A virus cellular receptor 1	Homo sapiens	24-29
32985287-8	2020	Circ-PRKCI was negatively correlated with serum creatinine, white blood cell, C-reactive protein, APACHE II score, SOFA score, but positively correlated with albumin, which also related to blood stream infection (as primary infection site) and anaerobes infection in sepsis patients.	Creatinine	48-58	protein kinase C iota	Homo sapiens	5-10
33263643-6	2020	In sepsis patients, SIRT1 negatively correlated with serum creatinine (Scr), white blood cells (WBC), C-reactive protein (CRP), acute physiology, and chronic health evaluation II (APACHE II) score, and sequential organ failure assessment (SOFA) score, while it positively correlated with albumin.	Creatinine	59-69	sirtuin 1	Homo sapiens	20-25
32952646-9	2020	The concentrations of CD68 and TGF-beta1 in the study group positively correlated with the renal injury indexes, such as blood urea nitrogen (BUN), serum creatinine (SCR), uric acid (UA) and the 24-h urinary protein quantity (P<0.05).	Creatinine	154-164	CD68 molecule	Homo sapiens	22-26
32968444-10	2020	Additionally, CT genotype at rs1799724 of TNF-alpha gene was related to the 24-h urine protein level (P=0.035), GG genotype at rs1800872 of IL-10 gene was associated with the plasma albumin level (P=0.031), and GG genotype at rs141219090 was related to the serum creatinine level (P=0.047).	Creatinine	263-273	interleukin 10	Homo sapiens	140-145
32767251-4	2020	Our results showed that a significant correlation existed between the expression of serum anti-PLA2R and age (MD = 2.91, 95% CI = 2.15-3.67, P < 0.00001), total serum cholesterol (MD = 35.52, 95% CI = 9.52-61.52, P = 0.007), urine protein by creatinine ratio (UPCR) (MD = 2.15, 95% CI = 1.86-2.44, P<0.00001), serum albumin (MD = -0.40, 95% CI = -0.56 to -0.23, P < 0.00001), eGFR (MD = -10.44, 95% CI = -12.19 to -8.68, P < 0.00001), unremission rate (RR = 1.76, 95% CI = 1.37-2.27, P < 0.0001).	Creatinine	242-252	phospholipase A2 receptor 1	Homo sapiens	95-100
32766700-11	2020	No significant changes in estimated glomerular filtration rate or UPCR occurred, but RBP:creatinine and beta2M:creatinine improved following the switch to TAF.	Creatinine	89-99	retinol binding protein 4	Homo sapiens	85-88
33305125-5	2020	There was a trend toward higher serum creatinine levels in patients with C3G compared with IC-MPGN both at diagnosis (mean 168.9 [range 45.4-292.4] vs. 93.7 [range 70.7-116.6] mumol/l, P = 0.25) and after a mean follow-up time of 4 years (mean 145.0 (range -8.1 to 298.1) vs 99.1 (range 46.3-151.9) mumol/l, P = 0.47), although the estimated glomerular filtration rate (eGFR) was not significantly different.	Creatinine	38-48	Rap guanine nucleotide exchange factor 1	Homo sapiens	73-76
32281000-6	2020	RESULTS: Univariate models showed significant associations between TNFR1 and TNFR2, respectively, and CRP, age and creatinine.	Creatinine	115-125	TNF receptor superfamily member 1B	Homo sapiens	77-82
32702804-9	2020	Further analysis revealed that in the subgroup of BPS > limit of detection (0.01 ng/ml), creatinine-adjusted BPS was significantly associated with increases in IL-10 (beta = 0.22, 95% CI = 0.00, 0.45; p = 0.048).	Creatinine	89-99	interleukin 10	Homo sapiens	160-165
32866127-5	2020	Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.	Creatinine	88-98	serpin family A member 4	Homo sapiens	6-17
32866127-8	2020	Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.	Creatinine	87-97	serpin family A member 4	Homo sapiens	6-17
32922997-11	2020	One year after KT, the creatinine clearance was higher (P = 0.006) in youngers (70.9 +- 25.2 mL/min/1.73 m2) versus elderlies (53.3 +- 21.1 mL/min/1.73 m2).	Creatinine	23-33	thrombopoietin	Mus musculus	93-95
32922997-11	2020	One year after KT, the creatinine clearance was higher (P = 0.006) in youngers (70.9 +- 25.2 mL/min/1.73 m2) versus elderlies (53.3 +- 21.1 mL/min/1.73 m2).	Creatinine	23-33	thrombopoietin	Mus musculus	140-142
32393465-2	2020	Current Kidney Disease Improving Global Outcomes guidelines recommend measurement of serum creatinine to estimate GFR as the initial step in GFR evaluation.	Creatinine	91-101	Rap guanine nucleotide exchange factor 5	Homo sapiens	141-144
32393465-4	2020	The guideline-recommended equation in adults (the 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine equation) includes a term for race (specified as black versus nonblack), which improves the accuracy of GFR estimation by accounting for differences in non-GFR determinants of serum creatinine by race in the study populations used to develop the equation.	Creatinine	105-115	Rap guanine nucleotide exchange factor 5	Homo sapiens	220-223
32710733-11	2020	The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage.	Creatinine	197-207	interleukin 18	Homo sapiens	86-91
32589133-4	2020	Linear regression analysis was used to assess the correlation of endogenous creatinine clearance (24-hour CLcr) and 24-hour CLcr x 0.715 (i.e., modified glomerular filtration rate (GFR)); with estimated kidney function from SCr and ScysC in 15 healthy young adult men with high muscle mass.	Creatinine	76-86	chymotrypsin C	Homo sapiens	106-110
32589133-4	2020	Linear regression analysis was used to assess the correlation of endogenous creatinine clearance (24-hour CLcr) and 24-hour CLcr x 0.715 (i.e., modified glomerular filtration rate (GFR)); with estimated kidney function from SCr and ScysC in 15 healthy young adult men with high muscle mass.	Creatinine	76-86	chymotrypsin C	Homo sapiens	124-128
32473378-12	2020	CONCLUSIONS: Among patients hospitalized for AHF with impaired kidney function, elevated AnxA1 levels are associated with worse congestion, higher risk for further creatinine elevation, and higher rates of 60-day morbidity or all-cause mortality & 180-day all-cause mortality.	Creatinine	164-174	annexin A1	Homo sapiens	89-94
32447505-6	2020	His initial creatinine kinase (CK) level was 427,656 U/L.	Creatinine	12-22	cytidine/uridine monophosphate kinase 1	Homo sapiens	31-33
32608481-9	2020	Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR.	Creatinine	66-76	high mobility group box 1	Rattus norvegicus	18-23
32673348-10	2020	In those subjects without clinically overt CKD (eGFR > 60 ml/min, urinary albumin creatinine ratio <30 mg/g), the NGAL/creatinine ratio was 2.6 higher in CI-AKI vs. no CI-AKI (47.8 [IQR 11.8-75.3] vs. 18.6 [IQR 11.7-36.3] mug/mg).	Creatinine	82-92	lipocalin 2	Homo sapiens	114-118
32673348-10	2020	In those subjects without clinically overt CKD (eGFR > 60 ml/min, urinary albumin creatinine ratio <30 mg/g), the NGAL/creatinine ratio was 2.6 higher in CI-AKI vs. no CI-AKI (47.8 [IQR 11.8-75.3] vs. 18.6 [IQR 11.7-36.3] mug/mg).	Creatinine	119-129	lipocalin 2	Homo sapiens	114-118
32673348-12	2020	ROC analyses revealed an area under the curve (AUC) of 0.68 (95% CI 0.60-0.81) for NGAL/creatinine.	Creatinine	88-98	lipocalin 2	Homo sapiens	83-87
32673348-13	2020	An NGAL/creatinine ratio < 56.4 mug/mg has a negative predictive value of 96.5%.	Creatinine	8-18	lipocalin 2	Homo sapiens	3-7
32207310-9	2020	Furthermore, a correlation was observed between insulin and homeostasis model assessment of insulin resistance levels with the NGAL/creatinine ratio in the overweight group (r = 0.515; p = 0.008, and r = 0.483; p = 0.014, respectively).	Creatinine	132-142	lipocalin 2	Homo sapiens	127-131
32414522-3	2020	We are herein to report two cases of SARS-CoV-2 induced rhabdomyolysis with an initial presentation of weakness and elevated creatinine kinase (CK).	Creatinine	125-135	cytidine/uridine monophosphate kinase 1	Homo sapiens	144-146
32387086-7	2020	It was found that CL/F increases with serum creatinine and uric acid levels and V1/F is modified by blood urea nitrogen and the UGT1A9 genotype.	Creatinine	44-54	cytokine receptor like factor 1	Homo sapiens	18-22
32342708-7	2020	The mean change in urinary UA concentration was -128.39 mg/g creatinine, and that of 6MWT walking distance was +31.8 m.Conclusion: Long-term idursulfase treatment was well tolerated, and effective in improving clinical features, reducing urinary UA, and slowing disease progression in Japanese MPS II patients.	Creatinine	61-71	iduronate 2-sulfatase	Homo sapiens	141-152
32447936-9	2020	Within lambda light chain type AL patients, peripheral CD8(+) T cell ratio was positively correlated with 24-hour urine protein and creatinine level and negatively correlated with estimated glomerular filtration rate (eGFR) .	Creatinine	132-142	CD8a molecule	Homo sapiens	55-58
31967738-10	2020	The addition of CT-IGFBP-4 to a clinical prediction model that included age, gender, systolic blood pressure, creatinine, and sodium levels, as well as the history of previous heart failure, coronary artery disease, and hypertension significantly improved the mortality risk prediction (ROC AUC 0.774 vs. 0.699, P = 0.025).	Creatinine	110-120	insulin like growth factor binding protein 4	Homo sapiens	16-26
31001662-10	2020	In the multivariable model, predicted GFR equation was 2.32* (weight (g))0.64/(creatinine (mcmol/l))0.62.	Creatinine	79-89	Rap guanine nucleotide exchange factor 5	Homo sapiens	38-41
32011218-8	2020	A significant correlation of bio-ADM concentrations from all available time points was observed with leukocytes (r = 0.37, P < 0.0001), C-reactive protein (r = 0.56, P < 0.001) and serum creatinine levels (r = 0.52, P < 0.001).	Creatinine	187-197	adrenomedullin	Homo sapiens	33-36
32232190-6	2020	Results: Serum NGAL was closely related to cystatin C, creatinine, urea, and estimated glomerular filtration rate (eGFR).	Creatinine	55-65	lipocalin 2	Homo sapiens	15-19
32176024-8	2020	DF patients carrying rs5498 AA genotype had significantly higher serum creatinine levels than GG genotype carriers (P = .003).ICAM1 rs3093030 polymorphism may act as a protective factor against DF developed from T2DM, moreover, rs5498 may be involved in onset of T2DM.Clinical trial number: ChiCTR-INR-18010231.	Creatinine	71-81	intercellular adhesion molecule 1	Homo sapiens	126-131
31994917-5	2020	Serum NGAL was also significantly related to serum ferritin, TIBC, uric acid, creatinine and blood sugar whereas, an inverse relationship with albumin, total cholesterol and LDL.	Creatinine	78-88	lipocalin 2	Homo sapiens	6-10
31937795-6	2020	With ML, the AKI predictive capability of NGAL was further enhanced when combined with NT-proBNP or creatinine.	Creatinine	100-110	lipocalin 2	Homo sapiens	42-46
32549781-8	2020	Nephrin in urine was measured by immunoenzyme assay, microalbumin with turbidimetric and creatinine with the photometric method.	Creatinine	89-99	NPHS1 adhesion molecule, nephrin	Homo sapiens	0-7
31924810-7	2020	Different genes showed association with biochemical parameters characteristic for CKD, such as creatinine (GPX1, GSTO1, GSTO2, KL, MGP), glomerular filtration rate (GPX1, GSTO1, KL, ICAM-1, MGP), hemoglobin (ERCC2, SHROOM3), resistance index erythropoietin (SOD2, VEGFA, MTHFR, KL), albumin (SOD1, GSTO2, ERCC2, SOD2), phosphorus (IL-4, ERCC4 SOD1, GPX4, GPX1), parathyroid hormone (IL-1A, IL-6, SHROOM3, UMOD, ICAM-1), C-reactive protein (SOD2, TGFB1,GSTP1, XRCC1), and ferritin (SOD2, GSTP1, SLC7A9, GPX4).	Creatinine	95-105	glutathione peroxidase 1	Homo sapiens	107-111
31918915-11	2020	ALX/FPR2 dysfunction magnified obesogenic cardiomyopathy and renal inflammation ( NGAL,  TNF-alpha,  CCL2,  IL-1beta) with elevated plasma creatinine levels in aging mice.	Creatinine	139-149	formyl peptide receptor 2	Mus musculus	4-8
32526762-7	2020	RESULTS: The results suggest that mTOR inhibition significantly attenuated the induction of fibrosis, with restored serum creatinine and blood urea nitrogen levels.	Creatinine	122-132	mechanistic target of rapamycin kinase	Rattus norvegicus	34-38
31257434-10	2020	The level of serum creatinine kinase was higher in patients with CD8+ T cells in muscle cells than those without these cells.	Creatinine	19-29	CD8a molecule	Homo sapiens	65-68
31646460-3	2019	KIM-1 staining scores were significantly correlated with serum creatinine (sCr) levels (P < 0.05) in all age groups.	Creatinine	63-73	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
31773054-5	2019	In children with s-creatinine increase, IL-6 values were significantly different between AR and cAMR.	Creatinine	19-29	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	96-100
31390230-6	2019	PTHrP was detected in rat urine by dot blot, and its quantification with two specific ELISA kits showed that, compared with control rats, those treated with cisplatin displayed a significant increase in urinary PTHrP (expressed as the PTHrP-to-creatinine ratio or 24-h excretion).	Creatinine	244-254	parathyroid hormone-like hormone	Rattus norvegicus	0-5
31390230-7	2019	In addition, a positive correlation between urinary PTHrP excretion and serum creatinine was found in these animals.	Creatinine	78-88	parathyroid hormone-like hormone	Rattus norvegicus	52-57
31411505-4	2019	Thus, we investigated whether plasma uromodulin measured at the time of admission is associated with subsequent hospital-acquired AKI (defined by a rise in serum creatinine >0.3mg/dL within 48 h or >= 1.5 times baseline) in patients with cirrhosis.	Creatinine	162-172	uromodulin	Homo sapiens	37-47
31197872-7	2019	RESULTS: Multivariate analyses established creatinine, cholesterol, body mass index and tumour necrosis factor as significant confounders for circulating chemerin levels.	Creatinine	43-53	retinoic acid receptor responder 2	Homo sapiens	154-162
31398463-6	2019	Expression of SOCS2 was significantly higher in T-cell-mediated rejection group compared with non-rejected individuals with creatinine rise (Relative expression difference [95% CrI] =6.74 [0.94, 12.65], P = 0.043).	Creatinine	124-134	suppressor of cytokine signaling 2	Homo sapiens	14-19
30700793-3	2019	We hypothesized that combining creatinine with serum cystatin C (cysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL) more effectively characterizes AKI during the first 28 days of HSCT and better identifies patients at risk of adverse outcomes than creatinine alone.	Creatinine	265-275	lipocalin 2	Homo sapiens	127-131
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 22 member 7	Homo sapiens	121-148
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 22 member 7	Homo sapiens	150-154
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 22 member 3	Homo sapiens	194-198
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 47 member 1	Homo sapiens	200-239
31176593-1	2019	Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K.	Creatinine	0-10	solute carrier family 47 member 1	Homo sapiens	241-246
31179646-8	2019	Urine IL-17A levels correlated positively with urine protein : creatinine index while serum IL-17 level correlated with the BILAG hematology score (all P &lt; 0.05).	Creatinine	63-73	interleukin 17A	Homo sapiens	6-12
31179646-8	2019	Urine IL-17A levels correlated positively with urine protein : creatinine index while serum IL-17 level correlated with the BILAG hematology score (all P &lt; 0.05).	Creatinine	63-73	interleukin 17A	Homo sapiens	6-11
31396527-1	2019	Objective: The aim of the study was to establish, by means of linear regressions analysis, whether RANTES and CCL2 have a relationship with age, sex, heart rate, ejection fraction, white blood cells count, monocyte count, platelet count, mean platelet volume, hsCRP concentration, creatinine and eGFR value, applied treatments, and coronary risk factors in polish cardiovascular disease patients.	Creatinine	281-291	C-C motif chemokine ligand 5	Homo sapiens	99-105
31379940-13	2019	Pearson correlation analysis showed that plasma chemerin levels were positively related to duration of diabetes, serum creatinine, and 24-hour urine albumin excretion, even after multiple adjustments.	Creatinine	119-129	retinoic acid receptor responder 2	Homo sapiens	48-56
30974283-7	2019	CXCL10 levels were also positively correlated with WBC count, creatinine and inflammatory cytokines including, IL-1beta, IL-6 and CXCL9, but negatively correlated with albumin.	Creatinine	62-72	C-X-C motif chemokine ligand 10	Homo sapiens	0-6
31062866-8	2019	RESULTS: The serum and urine NGAL levels were significantly increased in AIS patients with AKI, and line regression analysis indicated that there was a positive correlation between the serum NGAL and creatinine level in AIS patients accompanied AKI.	Creatinine	200-210	lipocalin 2	Homo sapiens	29-33
31062866-8	2019	RESULTS: The serum and urine NGAL levels were significantly increased in AIS patients with AKI, and line regression analysis indicated that there was a positive correlation between the serum NGAL and creatinine level in AIS patients accompanied AKI.	Creatinine	200-210	lipocalin 2	Homo sapiens	191-195
31097304-0	2019	Expression levels of serum vasohibin-1 and other biomarkers in type 2 diabetes mellitus patients with different urinary albumin to creatinine ratios.	Creatinine	131-141	vasohibin 1	Homo sapiens	27-38
31097304-1	2019	AIM: To determine the serum levels of vasohibin (VASH)-1 and other biomarkers in type 2 diabetes mellitus (T2DM) patients with different urinary albumin to creatinine ratios (UACR), and correlate VASH-1 expression with the inflammation and fibrosis in diabetic kidney disease (DKD).	Creatinine	156-166	vasohibin 1	Homo sapiens	38-56
30581063-12	2019	By contrast, urine Klotho/creatinine ratio, which was very low at baseline (34.6 +- 31.6 pg/mmoL), increased by 320% at two weeks (P < .005) and by 280% at 4 weeks (P < .01).	Creatinine	26-36	klotho	Homo sapiens	19-25
31185006-11	2019	RESULTS MiR-30c-5p agomir reduced serum Cr, serum NGAL, and renal I/R injury.	Creatinine	40-42	membrane associated ring-CH-type finger 8	Rattus norvegicus	8-11
30995111-5	2019	Recovery of kidney function on days 14/16, however, was improved in Sglt1-/- versus WT mice, as indicated by lower plasma creatinine, higher glomerula filtration rate (by FITC-sinistrin in awake mice), and more completely restored urine and plasma osmolality.	Creatinine	122-132	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	68-73
31086841-8	2019	Results: Group A patients with Anti TPO antibody positivity had more elevated TSH levels (p&lt;0.0001), proteinuria (p=0.0011) and serum creatinine (p=0.0137) as compared to group B patients.	Creatinine	137-147	thyroid peroxidase	Homo sapiens	36-39
30625599-2	2019	The rise in NGAL concentration, both in urine or plasma, appears earlier than for other classical renal function markers such as serum creatinine, thus making it a suitable marker for early pathology detection.	Creatinine	135-145	lipocalin 2	Homo sapiens	12-16
30979455-4	2019	RESULTS: The miR-142-5p, miR-142-3p, and miR-223 were significantly upregulated and miR-10b was significantly downregulated in recipients with abnormal levels of serum creatinine 3 to 4 weeks after initial sample collection.	Creatinine	168-178	microRNA 10b	Homo sapiens	84-91
30989103-7	2019	Urinary KIM-1 was normalized with urine creatinine concentration.	Creatinine	40-50	hepatitis A virus cellular receptor 1	Homo sapiens	8-13
30989103-11	2019	The creatinine normalized urinary KIM-1 was significantly higher when urine protein was 1 + to 3+ (0.75-5 g/L).	Creatinine	4-14	hepatitis A virus cellular receptor 1	Homo sapiens	34-39
33681514-6	2019	Their average measured creatinine clearance (mCCr) was 72.0 +- 21.5 mL/min.	Creatinine	23-33	LETM1 domain containing 1	Mus musculus	45-49
30562560-11	2019	TIMP2 silencing ameliorated CLP-induced proinflammatory cytokines, kidney dysfunction as measured by serum creatinine level, and histopathological changes.	Creatinine	107-117	TIMP metallopeptidase inhibitor 2	Homo sapiens	0-5
30599182-8	2019	Inhibitor of Syk signaling, R406 led to improvement of sepsis-induced AKI as depicted by an attenuation of creatinine/blood urea nitrogen in serum, renal myeloperoxidase activity, and repair of tubular structures in kidney.	Creatinine	107-117	spleen tyrosine kinase	Mus musculus	13-16
30620279-8	2019	Furthermore, serum LAMP-2 levels were correlated with Birmingham Vasculitis Activity Score (BVAS), C-reactive protein (CRP), hypersensitive CRP (Hs-CRP), serum creatinine (Scr) and 24-hour proteinuria (all p&lt;0.05).	Creatinine	160-170	lysosomal associated membrane protein 2	Homo sapiens	19-25
31074416-10	2019	The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine.	Creatinine	101-111	interleukin 10	Homo sapiens	26-31
31074416-10	2019	The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine.	Creatinine	101-111	interleukin 17A	Homo sapiens	48-53
29522788-7	2019	Among them, the levels of afamin, CD44 antigen, and lysosome-associated membrane glycoprotein 2, which have not previously been implicated in DN, were significantly associated with both the urinary albumin to creatinine ratio (ACR) and eGFR.	Creatinine	209-219	CD44 molecule (Indian blood group)	Homo sapiens	34-95
29522788-9	2019	The urinary afamin to creatinine ratio (Afa/Cre) was significantly higher in patients who progressed to a more severe DN stage or had early renal decline than in patients who did not.	Creatinine	22-32	AFA	Homo sapiens	40-43
30198834-6	2019	RESULTS: Logistic regression revealed an increase in NGAL (sNGAL p = 0.0263, uNGAL p = 0.0080) corresponding with an increase in serum creatinine within the first 48 hours.	Creatinine	135-145	lipocalin 2	Homo sapiens	53-57
30198834-11	2019	CONCLUSION: serum-NGAL and urine-NGAL correlate with serum creatinine levels and AKI requiring dialysis.	Creatinine	59-69	lipocalin 2	Homo sapiens	18-22
30198834-11	2019	CONCLUSION: serum-NGAL and urine-NGAL correlate with serum creatinine levels and AKI requiring dialysis.	Creatinine	59-69	lipocalin 2	Homo sapiens	33-37
30110569-3	2018	In adult kidneys ( n = 52 subjects), we found that the intensity of KIM-1 staining significantly correlated with the antemortem level of serum creatinine, and this was independent of the extent of tissue autolysis.	Creatinine	143-153	hepatitis A virus cellular receptor 1	Homo sapiens	68-73
30511581-5	2018	RESULTS: NGAL levels were positively correlated with galectin-3 (rho = 0.26; p = 0.04) and b-type natriuretic peptide levels (rho = 0.30; p = 0.005) and inversely correlated with ejection fraction (rho = -0.31; p = 0.02) and creatinine clearance levels.	Creatinine	225-235	lipocalin 2	Homo sapiens	9-13
30204280-4	2018	Diabetes, age, creatinine, high-sensitive troponin T, N-terminal pro-B-type natriuretic peptide, and New York Heart Association class III/IV were most strongly associated with elevated GDF-15 values (all P &lt; 0.001) (adjusted R2 = 0.3857).	Creatinine	15-25	growth differentiation factor 15	Homo sapiens	185-191
30320390-8	2018	Following surgery, EP4+/- mice presented a higher survival rate and normal urine volume compared with the WT group, and serum creatinine level and 24 h urine protein were lower in the EP4+/- mice.	Creatinine	126-136	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	184-187
30403420-8	2018	Overlapping performance was acceptable, as the assay was able to detect the expected differences of NGAL levels in horses with normal and elevated serum creatinine concentrations.	Creatinine	153-163	lipocalin 2	Homo sapiens	100-104
30442110-11	2018	In patients with sepsis, serum tenascin-C levels were significantly positively correlated with SOFA scores (P = 0.011), serum creatinine (P = 0.006), C-reactive protein (CRP) (P = 0.001), interleukin-6 (IL-6) (P &lt; 0.001), and tumor necrosis factor alpha (TNF-alpha) (P = 0.026).	Creatinine	126-136	tenascin C	Homo sapiens	31-41
30121167-3	2018	Recently, a new method for GFR estimation using mean normal values to rescale GFR marker concentrations has been described for creatinine and cystatin C, two commonly used endogenous markers for kidney function.	Creatinine	127-137	Rap guanine nucleotide exchange factor 5	Homo sapiens	27-30
30121167-3	2018	Recently, a new method for GFR estimation using mean normal values to rescale GFR marker concentrations has been described for creatinine and cystatin C, two commonly used endogenous markers for kidney function.	Creatinine	127-137	Rap guanine nucleotide exchange factor 5	Homo sapiens	78-81
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	Creatinine	21-31	fibromodulin	Homo sapiens	78-80
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	Creatinine	21-31	fibromodulin	Homo sapiens	84-86
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	Creatinine	138-148	fibromodulin	Homo sapiens	78-80
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	Creatinine	138-148	fibromodulin	Homo sapiens	78-80
30348306-4	2018	Serum ZAG concentrations were inversely associated with serum albumin, creatinine, and triglycerides and, conversely, positively associated with age.	Creatinine	71-81	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	6-9
30378177-10	2018	Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine-1 ) independently predicted GFR in the final multivariate model.	Creatinine	97-107	Rap guanine nucleotide exchange factor 5	Homo sapiens	162-165
30378177-10	2018	Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine-1 ) independently predicted GFR in the final multivariate model.	Creatinine	123-133	Rap guanine nucleotide exchange factor 5	Homo sapiens	162-165
29958959-13	2018	In vivo, LEP treatment significantly reduced the effects of CCl4 intoxication on serum liver biomarkers (AST, ALT, LDH, and GGT) and the effect of cisplatin on serum renal biomarkers (urea, blood urea nitrogen, creatinine, and uric acid).	Creatinine	211-221	chemokine (C-C motif) ligand 4	Mus musculus	60-64
29095812-2	2018	METHODS: The new marker is a ratio calculated between the creatine/creatinine (Cre/Crn) ratio as the numerator and the activity of acid alpha-glucosidase (GAA) as the denominator.	Creatinine	67-77	crooked neck pre-mRNA splicing factor 1	Homo sapiens	83-86
29956754-4	2018	The results of the present study revealed that urinary CXCL13/creatinine (Cr) was lower in normal transplants compared with in those with acute tubular necrosis (ATN; P=0.001), chronic allograft nephropathy (CAN; P=0.01), and acute rejection (AR; P&lt;0.0001), which was associated with a good diagnostic performance for AR [area under the curve (AUC)=0.818, P&lt;0.0001).	Creatinine	62-72	C-X-C motif chemokine ligand 13	Homo sapiens	55-61
29883532-6	2018	Concentrations of [TIMP-2] [IGFBP7] increase before a rise in serum creatinine is evident, thus providing insightful information for evaluation in the context of other patient data to predict the risk for impending kidney injury.	Creatinine	68-78	TIMP metallopeptidase inhibitor 2	Homo sapiens	19-25
30022770-6	2018	Multiple linear regression analysis showed that the serum creatinine and left ventricular ejection fraction were significantly effective factors influencing IL-18 (P &lt; 0.01).	Creatinine	58-68	interleukin 18	Homo sapiens	157-162
30143492-2	2018	Therefore, in the clinical circumstance of an urinoma, utilizing a creatinine-based estimated GFR (eGFR) to determine renal function is unreliable, as it fails to distinguish true renal failure from pseudorenal failure in patients with a urine leakage.	Creatinine	67-77	Rap guanine nucleotide exchange factor 5	Homo sapiens	94-97
29132705-4	2018	Here, we demonstrated that administration of IL-17A-pretreated MSCs resulted in significantly lower acute tubular necrosis scores, serum creatinine, and BUN of mice with IRI-AKI, compared with the administration of MSCs.	Creatinine	137-147	interleukin 17A	Mus musculus	45-51
29516098-11	2018	Greater age, lower estimated glomerular filtration rate, higher urine albumin to creatinine ratio, and female sex were associated with higher FGF23 concentration at baseline.	Creatinine	81-91	fibroblast growth factor 23	Homo sapiens	142-147
29596409-9	2018	IFN-gamma/IL-10 ratio and CRP values marked the immune biosignature of vivax malaria patients, and could distinguish subjects with elevated creatinine levels who did not survive from those who did.	Creatinine	140-150	interleukin 10	Homo sapiens	10-15
29678848-6	2018	Serum RBP4 was positively related to serum urea, CREA and CysC (P&lt;0.01).	Creatinine	49-53	retinol binding protein 4	Homo sapiens	6-10
29422602-7	2018	Soluble (pro)renin receptor concentrations in effluents of patients undergoing peritoneal dialysis were associated with the dialysate-to-plasma ratio of creatinine.	Creatinine	153-163	ATPase H+ transporting accessory protein 2	Homo sapiens	13-27
29779026-7	2018	UMOD expression is significantly correlated to albumin creatinine ratio (ACR), eGFR, and HbA1c.	Creatinine	55-65	uromodulin	Homo sapiens	0-4
28677090-0	2017	Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients.	Creatinine	66-76	klotho	Homo sapiens	0-6
28677090-1	2017	PURPOSE: The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD.	Creatinine	124-134	klotho	Homo sapiens	72-78
31966633-10	2017	There was a significant positive correlation of total score of KIM-1 expression and the parameters of kidney function for AKI, including serum creatinine (Cr) and blood urea nitrogen (BUN).	Creatinine	143-153	hepatitis A virus cellular receptor 1	Homo sapiens	63-68
31966633-10	2017	There was a significant positive correlation of total score of KIM-1 expression and the parameters of kidney function for AKI, including serum creatinine (Cr) and blood urea nitrogen (BUN).	Creatinine	155-157	hepatitis A virus cellular receptor 1	Homo sapiens	63-68
28500075-4	2017	Transgenic mice expressing hCD55 alone were protected against mild renal IRI, with reduced creatinine and urea levels compared with wild type littermates.	Creatinine	91-101	CD55 molecule (Cromer blood group)	Homo sapiens	27-32
28584738-8	2017	Logistic regression analysis showed that creatinine and urea (R2 = 0.75 and R2 = 0.72, respectively, P &lt; 0.001 for both) were better predictors of kidney disease than MAU (R2 = 0.64, P &lt; 0.001) and KIM-1 (R2 = 0.046, P = 0.116).	Creatinine	41-51	hepatitis A virus cellular receptor 1	Homo sapiens	204-209
28271116-4	2017	However, while both M-H-B interactions are almost identical in complex 1, this is not the case in complex 2, in which one M-H-B interaction is more agostic than the other due to the different trans influence of the hydride and phosphane ligands.	Creatinine	215-222	MHB	Homo sapiens	122-127
28861439-3	2017	This article provides additional data on the association of the creatinine to uromodulin ratio with its power to predict cardiovascular events and major cardiovascular events in coronary patients.	Creatinine	64-74	uromodulin	Homo sapiens	78-88
28861439-4	2017	In addition, this data article demonstrates the performance of the creatinine to uromodulin ratio as a biomarker using c-statistics.	Creatinine	67-77	uromodulin	Homo sapiens	81-91
28228465-4	2017	Residual GFR calculated using 24-hour urine collection was determined by an average of renal urea and creatinine clearance on the basis of 24-hour urine collection.	Creatinine	102-112	Rap guanine nucleotide exchange factor 5	Homo sapiens	9-12
28356664-12	2017	To conclude, all three estimating equations based on serum creatinine are superior to Tc-99m DTPA scintigraphy for estimating GFR; CKD-EPI equation being the most accurate and precise.	Creatinine	59-69	Rap guanine nucleotide exchange factor 5	Homo sapiens	126-129
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	122-132	klotho	Homo sapiens	56-62
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	122-132	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho	Homo sapiens	56-62
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho	Homo sapiens	56-62
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho beta	Homo sapiens	67-78
27558560-6	2017	In addition, the FGF-23 FE by the kidney was significantly directly related to eGFR (r = 0.709 P = 0.018) and to kidney creatinine FE (r = 0.736 P = 0.013) but only as a trend to plasma phosphate levels (r = 0.55, P = 0.18).	Creatinine	120-130	fibroblast growth factor 23	Homo sapiens	17-23
28611789-6	2017	GDF15 levels (mean +- SD 5.94 +- 3.90 ng/mL; range 1.58-39.8 ng/mL) were higher among older patients and were inversely associated with serum creatinine concentrations as a surrogate for muscle mass.	Creatinine	142-152	growth differentiation factor 15	Homo sapiens	0-5
27609616-5	2017	Notably, compared with administration of vehicle or mutant inactive peptide, administration of the SOCS1 peptidomimetic at either early or advanced stages of diabetes ameliorated STAT activity and resulted in reduced serum creatinine level, albuminuria, and renal histologic changes (mesangial expansion, tubular injury, and fibrosis) over time.	Creatinine	223-233	suppressor of cytokine signaling 1	Mus musculus	99-104
26857687-7	2017	RESULTS: After 28 days of PD treatment, CRP-Tg mice had higher dialysate-to-plasma (D/P) creatinine ratio than that of WT mice.	Creatinine	89-99	C-reactive protein, pentraxin-related	Mus musculus	40-43
28103909-10	2017	IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p &lt; 0.05).	Creatinine	135-145	hepatitis A virus cellular receptor 1	Homo sapiens	87-91
27966578-4	2016	We retrospectively analyzed 92 workers exposed to occupational lead and demonstrated a better correlation ship between blood lead levels and urine excretion of KIM-1 than other traditional renal injury biomarkers following creatinine adjustment.	Creatinine	223-233	hepatitis A virus cellular receptor 1	Homo sapiens	160-165
27334720-6	2016	The IL-17A(-/-) septic mice exhibited decreased serum creatinine and blood urea nitrogen levels and an improved acute tubular necrosis score.	Creatinine	54-64	interleukin 17A	Mus musculus	4-10
27659464-5	2016	The primary outcome was whether plasma NGAL could predict the development of WRF, defined as a sustained increase in plasma creatinine of 0.5 mg/dl or &gt;=50% above first value or initiation of acute renal-replacement therapy, within the first 5 days of hospitalization.	Creatinine	124-134	lipocalin 2	Homo sapiens	39-43
27659465-0	2016	Plasma NGAL: So, it Really Is Just Expensive Creatinine!	Creatinine	45-55	lipocalin 2	Homo sapiens	7-11
27866548-11	2016	The levels of the plasma Bun and Cr in Poisoned and intervention group were significantly higher than that in Control group in the six to seventy-two hours (P&lt;0.01) ; Whereas the increases of Bun and Cr were markedly intibited in PEP-1/HO-1 intervention group, in which, the levels of Bun and Cr in the six to seventy-two hours were significantly lower than Poisoned group (P&lt;0.05).	Creatinine	203-205	heme oxygenase 1	Rattus norvegicus	239-243
27866548-11	2016	The levels of the plasma Bun and Cr in Poisoned and intervention group were significantly higher than that in Control group in the six to seventy-two hours (P&lt;0.01) ; Whereas the increases of Bun and Cr were markedly intibited in PEP-1/HO-1 intervention group, in which, the levels of Bun and Cr in the six to seventy-two hours were significantly lower than Poisoned group (P&lt;0.05).	Creatinine	203-205	heme oxygenase 1	Rattus norvegicus	239-243
26860774-1	2016	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) accumulates in cortical tubules in acute kidney injury (AKI) patients, with its levels associated with serum creatinine.	Creatinine	171-181	lipocalin 2	Homo sapiens	12-54
26860774-1	2016	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) accumulates in cortical tubules in acute kidney injury (AKI) patients, with its levels associated with serum creatinine.	Creatinine	171-181	lipocalin 2	Homo sapiens	56-60
27181911-13	2016	For the alkaline picrate methods, a measured change of creatinine of 0.23mg/dL for AP1 or 0.11mg/dL for AP2 would indicate that a physiologic change in serum/plasma creatinine has occurred.	Creatinine	55-65	transcription factor AP-2 alpha	Homo sapiens	104-107
27181911-13	2016	For the alkaline picrate methods, a measured change of creatinine of 0.23mg/dL for AP1 or 0.11mg/dL for AP2 would indicate that a physiologic change in serum/plasma creatinine has occurred.	Creatinine	165-175	transcription factor AP-2 alpha	Homo sapiens	104-107
27398022-5	2016	Urinary IL-18 levels increased significantly at three hours (10.7 vs. 7.3 ng/mg creatinine; P &lt; 0.05).	Creatinine	80-90	interleukin 18	Homo sapiens	8-13
27330813-10	2016	Three hours after surgery, NGAL levels were 950.5 +- 827.9 and 430.0 +- 250.6 mug/g Cr in the AKI and non-AKI groups, respectively, the level being significantly higher in the AKI group than in the non-AKI group.	Creatinine	84-86	lipocalin 2	Homo sapiens	27-31
27830181-8	2016	Follistatin treatment significantly reduced the level of serum activin B and subsequently blunted the increase in activin A. Renoprotection was evident with the attenuated rise in serum creatinine, KIM-1 and NGAL expression, tubular injury score, renal cell apoptosis, and serum IL-6 and monocyte chemotactic protein-1 levels.	Creatinine	186-196	follistatin	Mus musculus	0-11
26597253-4	2016	As a positive control, the longitudinal effects of famotidine on the plasma levels of creatinine (an endogenous substrate of MATE1) were quantified in parallel.	Creatinine	86-96	solute carrier family 47 member 1	Homo sapiens	125-130
26972903-10	2016	RESULTS AND CONCLUSIONS: Both, blood cystatin C and NGAL, levels showed significant correlation with Cr (p = 0.05 and p = 0.01, respectively).	Creatinine	101-103	lipocalin 2	Homo sapiens	52-56
27247502-5	2016	Serum chemerin level showed positive correlation with fasting insulin, HOMA-IR, serum triglyceride, serum creatinine, urine albumin/creatinine ratio, high-sensitivity C-reactive protein (hsCRP), fibrinogen, abdominal visceral fat area, visceral to subcutaneous fat area ratio, and negatively correlation with high density lipoprotein cholesterol and creatinine clearance (CCr) after adjusting for age, gender and body mass index.	Creatinine	106-116	retinoic acid receptor responder 2	Homo sapiens	6-14
27247502-5	2016	Serum chemerin level showed positive correlation with fasting insulin, HOMA-IR, serum triglyceride, serum creatinine, urine albumin/creatinine ratio, high-sensitivity C-reactive protein (hsCRP), fibrinogen, abdominal visceral fat area, visceral to subcutaneous fat area ratio, and negatively correlation with high density lipoprotein cholesterol and creatinine clearance (CCr) after adjusting for age, gender and body mass index.	Creatinine	132-142	retinoic acid receptor responder 2	Homo sapiens	6-14
27247502-5	2016	Serum chemerin level showed positive correlation with fasting insulin, HOMA-IR, serum triglyceride, serum creatinine, urine albumin/creatinine ratio, high-sensitivity C-reactive protein (hsCRP), fibrinogen, abdominal visceral fat area, visceral to subcutaneous fat area ratio, and negatively correlation with high density lipoprotein cholesterol and creatinine clearance (CCr) after adjusting for age, gender and body mass index.	Creatinine	132-142	retinoic acid receptor responder 2	Homo sapiens	6-14
26583566-11	2016	2 mg/kg LPS injection produced a rise in creatinine (0.79 +- 0.27 mg/dl in CCl4 +LPS compared to 0.45 +- 0.14 in CCl4 alone, P &lt; 0.05) and a decrease in UOP (0.86 +- 0.4 ml/16 h in CCl4 + LPS compared to 1.70 +- 0.7 ml/16 h in CCl4 mice, P &lt; 0.05).	Creatinine	41-51	chemokine (C-C motif) ligand 4	Mus musculus	75-79
27149121-3	2016	Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a well-accepted early biomarker of subclinical kidney tubular injury, preceding an increase in serum creatinine.	Creatinine	162-172	lipocalin 2	Homo sapiens	52-56
26857862-7	2016	Serum ZAG concentration was positively correlated with serum creatinine and eGFR.	Creatinine	61-71	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	6-9
26859865-4	2016	Pyridine and pyrazine derivatives appear to have a similar ~1.2 Hz (4)J coupling to p-H2 derived hydrides for their ortho protons, and a much lower (5)J coupling for their meta protons.	Creatinine	97-105	polyhomeotic homolog 2	Homo sapiens	84-88
27471743-0	2016	Role of plasma neutrophil gelatinase-associated lipocalin as an emerging biomarker of acute renal failure following kidney transplantation and its correlation with plasma creatinine.	Creatinine	171-181	lipocalin 2	Homo sapiens	15-57
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	44-54	mucin 16, cell surface associated	Homo sapiens	272-277
26981446-5	2016	RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P &lt; 0.001), IL-6 (rho = 0.46, P &lt; 0.001), and hyaluronan (rho = 0.27, P &lt; 0.001), but not CA125 (rho = 0.13, P = 0.051).	Creatinine	56-58	mucin 16, cell surface associated	Homo sapiens	272-277
26750742-0	2016	Altered serum levels of FGF-23 and magnesium are independent risk factors for an increased albumin-to-creatinine ratio in type 2 diabetics with chronic kidney disease.	Creatinine	102-112	fibroblast growth factor 23	Homo sapiens	24-30
26750742-1	2016	AIMS: To investigate the role of FGF-23 and magnesium in relation to the albumin-to-creatinine ratio in type 2 diabetics with chronic kidney disease (CKD) stages 2-4.	Creatinine	84-94	fibroblast growth factor 23	Homo sapiens	33-39
26850185-8	2016	RESULTS: PMX-DHP maintained hemodynamics and the acid-base balance and significantly (P &lt; 0.05) decreased the plasma concentrations of lactate, creatinine, potassium, IL-6, and IL-10 compared with dummy-DHP.	Creatinine	147-157	dihydropyrimidinase	Rattus norvegicus	13-16
28115789-14	2016	The duration of treatment had a statistically significant influence on the NGAL to creatinine ratio.	Creatinine	83-93	lipocalin 2	Homo sapiens	75-79
27513835-10	2016	Serum and urine NGAL concentrations were signifcantly correlated with levels of serum urea, creatinine, urine albumin, and the maximum change in serum creatinine.	Creatinine	92-102	lipocalin 2	Homo sapiens	16-20
27513835-10	2016	Serum and urine NGAL concentrations were signifcantly correlated with levels of serum urea, creatinine, urine albumin, and the maximum change in serum creatinine.	Creatinine	151-161	lipocalin 2	Homo sapiens	16-20
26481479-9	2016	We also found significant correlations between serum creatinine and liver PCSK9 mRNA levels (r = 0.88, p &lt; 0.001) and between serum creatinine and circulating PCSK9 levels (r = 0.73, p &lt; 0.001).	Creatinine	53-63	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	74-79
26481479-9	2016	We also found significant correlations between serum creatinine and liver PCSK9 mRNA levels (r = 0.88, p &lt; 0.001) and between serum creatinine and circulating PCSK9 levels (r = 0.73, p &lt; 0.001).	Creatinine	135-145	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	162-167
26627016-10	2016	Inflammation related hepcidin and NGAL weakly correlated with creatinine clearance.	Creatinine	62-72	lipocalin 2	Homo sapiens	34-38
26447633-5	2015	Creatinine concentrations 12, 24, 36, 48, and 60 months after transplantation were significantly higher in recipients with the rs2275913:A&gt;G IL17A GG genotype (GG vs. GA + AA: p = 0.03, p = 0.004, p = 0.006, p = 0.03, p = 0.04, respectively).	Creatinine	0-10	interleukin 17A	Homo sapiens	144-149
26451602-9	2015	Perfusate NGAL correlated with donor age (r2 = 0.094, p = 0.01) and serum creatinine (r2 = 0.243, p = 0.05).	Creatinine	74-84	lipocalin 2	Homo sapiens	10-14
26248472-7	2015	Median values of urinary KIM-1 were higher in patients with AKI than in those without AKI [10.7, interquartile range (IQR) 1.6-17.9 vs. 4.3 (IQR 1.3-6.1) ng/mg creatinine; p &lt; 0.01].	Creatinine	160-170	hepatitis A virus cellular receptor 1	Homo sapiens	25-30
29967824-6	2015	Results: ROC curve analysis showed a better discriminatory capacity in terms of early diagnosis of AKI for NGAL (AUC=0.81 for NGAL, AUC=0.59 for creatinine, AUC=0.62 for corrected creatinine, AUC=0.29 for creatinine clearance).	Creatinine	145-155	lipocalin 2	Homo sapiens	107-111
29967824-6	2015	Results: ROC curve analysis showed a better discriminatory capacity in terms of early diagnosis of AKI for NGAL (AUC=0.81 for NGAL, AUC=0.59 for creatinine, AUC=0.62 for corrected creatinine, AUC=0.29 for creatinine clearance).	Creatinine	180-190	lipocalin 2	Homo sapiens	107-111
29967824-6	2015	Results: ROC curve analysis showed a better discriminatory capacity in terms of early diagnosis of AKI for NGAL (AUC=0.81 for NGAL, AUC=0.59 for creatinine, AUC=0.62 for corrected creatinine, AUC=0.29 for creatinine clearance).	Creatinine	180-190	lipocalin 2	Homo sapiens	107-111
29967824-7	2015	The value of likelihood ratio was also significantly higher for NGAL (3.01+-2.73 for NGAL, 1.27+-1.14 for creatinine, 1.78+-1.81 for corrected creatinine, and 0.48+-0.33 for creatinine clearance).	Creatinine	106-116	lipocalin 2	Homo sapiens	64-68
29967824-7	2015	The value of likelihood ratio was also significantly higher for NGAL (3.01+-2.73 for NGAL, 1.27+-1.14 for creatinine, 1.78+-1.81 for corrected creatinine, and 0.48+-0.33 for creatinine clearance).	Creatinine	143-153	lipocalin 2	Homo sapiens	64-68
29967824-7	2015	The value of likelihood ratio was also significantly higher for NGAL (3.01+-2.73 for NGAL, 1.27+-1.14 for creatinine, 1.78+-1.81 for corrected creatinine, and 0.48+-0.33 for creatinine clearance).	Creatinine	143-153	lipocalin 2	Homo sapiens	64-68
26407820-6	2015	RESULTS: The urinary levels normalized with urine creatinine of KIM-1 and MCP-1, but not NGAL, NAG, and beta2-microglobulin in AKI (+) samples were significantly higher than those in AKI (-) samples.	Creatinine	50-60	hepatitis A virus cellular receptor 1	Homo sapiens	64-69
26503599-9	2015	In male PCK rats, age-related increases in blood urea nitrogen and creatinine at 10 to 19 weeks of age were observed, and the cystic progression was more severe than that in females.	Creatinine	67-77	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	8-11
25948873-8	2015	At the time of ABMR, urinary CXCL10:Cr ratio was independently associated with an increased risk of graft loss.	Creatinine	36-38	C-X-C motif chemokine ligand 10	Homo sapiens	29-35
25948873-9	2015	In conclusion, urinary CXCL10:Cr ratio associates with tubulointerstitial and microvascular inflammation of the renal allograft.	Creatinine	30-32	C-X-C motif chemokine ligand 10	Homo sapiens	23-29
25634253-9	2015	UACR was positively correlated to urine NGAL-creatinine ratio (UNCR) and urine Cystatin C-creatinine ratio (UCCR) in both diabetes and pre-diabetes.	Creatinine	45-55	lipocalin 2	Homo sapiens	40-44
26108065-4	2015	Renal injury, assessed by serum creatinine and renal tubular injury scores after 24 h of reperfusion, was significantly exacerbated in SerpinC1(+/-) rats compared to wild-type littermates.	Creatinine	32-42	serpin family C member 1	Rattus norvegicus	135-143
26399271-10	2015	MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores.	Creatinine	59-69	matrix metallopeptidase 9	Homo sapiens	18-23
25648880-7	2015	Glomerular IFN-gamma and IL-17 staining grades correlated with the urinary protein/creatinine ratio (r = 0.62, p = 0.02 and r = 0.507, p = 0.016, respectively).	Creatinine	83-93	interleukin 17A	Homo sapiens	25-30
26382171-3	2015	BHPF pretreatment significantly (p &lt; 0.001) inhibited the CCl4-induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner.	Creatinine	136-146	chemokine (C-C motif) ligand 4	Mus musculus	61-65
25715120-5	2015	We found significant SYK expression in proliferative glomerulonephritis and that glomerular expression levels correlated with presenting serum creatinine and histological features of disease activity that predict outcome in IgA nephropathy, lupus nephritis, ANCA-associated glomerulonephritis, and antiglomerular basement membrane disease.	Creatinine	143-153	spleen associated tyrosine kinase	Homo sapiens	21-24
26161015-9	2015	The renal Klotho score showed a significant negative correlation with the initial or peak creatinine level.	Creatinine	90-100	klotho	Homo sapiens	10-16
26161015-10	2015	When the patients were divided into three groups according to the Klotho score (low, middle, high), the low group had a significantly higher peak creatinine level and a more frequent requirement for RRT.	Creatinine	146-156	klotho	Homo sapiens	66-72
25645468-8	2015	uses NGAL not only to predict serum creatinine-based AKI, but also to define AKI to associate a Day 1 NGAL concentration above a specific threshold with clinical outcomes.	Creatinine	36-46	lipocalin 2	Homo sapiens	5-9
25790277-7	2015	NGAL levels were correlated with the serum levels of leukocytes, C-reactive protein, and creatinine, as well as fever duration (P &lt; 0.05).	Creatinine	89-99	lipocalin 2	Homo sapiens	0-4
26162288-11	2015	NGAL correlated significantly with creatinine (r=0.50; p&lt;0.0001), albuminuria (r=0.33; p=0.008), and eGFR (r=-0.47; p=0.0001) but not with BNP (r=0.003; p=0.97).	Creatinine	35-45	lipocalin 2	Homo sapiens	0-4
26121471-8	2015	Serum creatinine and urine albumin to creatinine ratio were significantly decreased in p210 immunized mice suggesting that p210 vaccine had renal protective effect.	Creatinine	6-16	envoplakin	Mus musculus	87-91
26121471-8	2015	Serum creatinine and urine albumin to creatinine ratio were significantly decreased in p210 immunized mice suggesting that p210 vaccine had renal protective effect.	Creatinine	6-16	envoplakin	Mus musculus	123-127
26121471-8	2015	Serum creatinine and urine albumin to creatinine ratio were significantly decreased in p210 immunized mice suggesting that p210 vaccine had renal protective effect.	Creatinine	38-48	envoplakin	Mus musculus	87-91
26121471-8	2015	Serum creatinine and urine albumin to creatinine ratio were significantly decreased in p210 immunized mice suggesting that p210 vaccine had renal protective effect.	Creatinine	38-48	envoplakin	Mus musculus	123-127
26053644-5	2015	IRI induced more severe injury in Sca-1 null kidneys, as assessed by increased expression of Kim-1 and Ngal, rise in serum creatinine, abnormal pathology, and increased apoptosis of tubular epithelium, and persistent significant renal injury at day 7 post IRI, when recovery of renal function in control animals was nearly complete.	Creatinine	123-133	lymphocyte antigen 6 complex, locus A	Mus musculus	34-39
26042740-7	2015	RESULTS: Biomarker with best accuracy for ATN diagnosis was NGAL (neutrophil-gelatinase associated lipocalin): 36 [26-125], 104 [58-208] and 1807 [494-3,716] mug/g creatinine in Prerenal-AKI, type-1 HRS and ATN, respectively; p&lt;0.0001 (AUROC 0.957).	Creatinine	164-174	lipocalin 2	Homo sapiens	66-108
26042740-9	2015	For ACLF, the biomarker with the best accuracy was NGAL (ACLF vs. No-ACLF: 165 [67-676] and 32 [19-40] mug/g creatinine; respectively; p&lt;0.0001; AUROC 0.878).	Creatinine	109-119	lipocalin 2	Homo sapiens	51-55
26273116-1	2015	Micellar nanoreactors derived from commercially available "Nok" (SPGS-550-M), in the presence of Fu"s catalyst and a mild hydride source (NaBH4), are useful for facile debromination of functionalized aromatic derivatives.	Creatinine	122-129	serine/threonine/tyrosine kinase 1	Homo sapiens	59-62
26035554-7	2015	Urinary CFH levels were measured by enzyme-linked immunosorbent assay and calculated as the ratio of urinary CFH over creatinine (uCFH/uCr).	Creatinine	118-128	complement factor H	Homo sapiens	8-11
25471594-6	2015	RESULTS: In the overall group, the combination creatinine and cystatin C equation had 69% of results within 20% of GFR (P20), a sensitivity of 86.3% and a specificity of 73.1% to detect reduced GFR at &lt;90 mL/min/1.73 m(2), and a concordance of 78%.	Creatinine	47-57	tubulin polymerization promoting protein family member 3	Homo sapiens	120-123
25784666-4	2015	KIM-1 was measured at baseline and normalized with urinary creatinine.	Creatinine	59-69	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
25725314-3	2015	Because expression of CD55 but not CD46 and CD59 in mesothelial cells was significantly correlated to value of dialysate-to-plasma creatinine concentration ratio (D/P Cre) (p&lt;0.005) as an indicator of peritoneal function, we focused on analysis of CD55 expression of HPMCs in comparison with levels of C activation products in the PDF of the PD patients, and their background factors.	Creatinine	131-141	CD55 molecule (Cromer blood group)	Homo sapiens	22-26
25786223-7	2015	Urinary ACE2 activity correlated positively with urinary protein excretion (P&lt;0.001), and negatively with creatinine clearance (P=0.04).	Creatinine	109-119	angiotensin I converting enzyme 2	Rattus norvegicus	8-12
25210758-11	2015	Albumin/creatinine ratio had a significant positive correlation with chemerin and OxLDL, and a negative correlation with ADMA.	Creatinine	8-18	retinoic acid receptor responder 2	Homo sapiens	69-77
25210758-13	2015	Vaspin had a significant relation to CAN, whereas chemerin, ADMA, and OxLDL had a significant correlation with albumin/creatinine ratio that reflects their role in renal affection.	Creatinine	119-129	retinoic acid receptor responder 2	Homo sapiens	50-58
25437644-3	2015	In UUO rats, CNP administration induced a significant increase in plasma CNP levels, and caused a significant decrease in blood urea nitrogen and creatinine levels.	Creatinine	146-156	natriuretic peptide C	Rattus norvegicus	13-16
25531567-4	2015	SAA was increased in the plasma of people with DKD characterized by overt proteinuria and inversely correlated with estimated glomerular filtration rate (creatinine-based CKD-EPI).	Creatinine	154-164	serum amyloid A1 cluster	Homo sapiens	0-3
25245074-10	2015	The urinary nephrin expression was positively related to podocyte and urinary albumin/creatinine ratio.	Creatinine	86-96	NPHS1 adhesion molecule, nephrin	Homo sapiens	12-19
25485598-8	2015	Six SNPs, present in OCRL (four SNPs) and ABCC2 (two SNPs), were significantly associated with increased serum creatinine levels in the cases, and this association remained significant after multiple test correction (P &lt; 2 x 10).	Creatinine	111-121	ATP binding cassette subfamily C member 2	Homo sapiens	42-47
25485598-9	2015	One synonymous SNP in ABCC2 (rs8187707, P = 2.10 x 10, beta = -73.3 ml/min/1.73 m(2)) was also significantly associated with the decreased estimated glomerular filtration rate of creatinine among cases.	Creatinine	179-189	ATP binding cassette subfamily C member 2	Homo sapiens	22-27
25516918-11	2015	The serum creatinine level at biopsy correlated with the glomerular CD68 and neutrophil scores (r=0.74 and r=0.71, respectively; P=0.001) but did not correlate with the extent of fibrinoid necrosis (r=0.36).	Creatinine	10-20	CD68 molecule	Homo sapiens	68-72
25556925-8	2015	When the subjects were divided into 2 groups according to the genotypes of the klotho gene polymorphism, in the GA+AA genotype distributions of the rs1207568, the differences I serum creatinine and estimated glomerular filtration rate between the Kazak and Uygur groups were statistically significant (P&lt;0.05, respectively).	Creatinine	183-193	klotho	Homo sapiens	79-85
25563323-16	2015	Creatinine clearance and the number of methotrexate chemotherapy cycles before MTX infusion had a significant effect on the CL1, and body surface area had a significant effect on the CL2 and the V2 (P &lt; 0.	Creatinine	0-10	endogenous retrovirus group W member 5	Homo sapiens	183-186
25528363-13	2014	After stratifying the patients according to their baseline serum creatinine levels, the negative prognostic association of increased FGF-23 was only significant in those with serum creatinine greater than median.	Creatinine	65-75	fibroblast growth factor 23	Homo sapiens	133-139
25528363-13	2014	After stratifying the patients according to their baseline serum creatinine levels, the negative prognostic association of increased FGF-23 was only significant in those with serum creatinine greater than median.	Creatinine	181-191	fibroblast growth factor 23	Homo sapiens	133-139
25514679-8	2014	At multivariate analysis, RAGE was associated to age and creatinine, SP-A to DLCO and BNP, SP-D to BNP, mature SP-B to DLCO and creatinine, and immature SP-B only but strongly to DLCO.	Creatinine	57-67	long intergenic non-protein coding RNA 914	Homo sapiens	26-30
25514679-8	2014	At multivariate analysis, RAGE was associated to age and creatinine, SP-A to DLCO and BNP, SP-D to BNP, mature SP-B to DLCO and creatinine, and immature SP-B only but strongly to DLCO.	Creatinine	128-138	long intergenic non-protein coding RNA 914	Homo sapiens	26-30
24947687-7	2014	Among all MHD patients, the lowest BMI, nPNA, nPCR, GNRI, serum albumin, creatinine, phosphate, Ca, Ca x P product and iPTH values were seen in the lowest serum FGF-23 quartile (FGF-23&lt;311 pg/mL).	Creatinine	73-83	fibroblast growth factor 23	Homo sapiens	161-167
24918613-6	2014	SPI-6 null kidney recipients demonstrated reduced renal function at day 8 after transplantation compared to controls (creatinine, 113+-23 vs. 28+-3 mumol/L; n=5; P&lt;0.01), consistent with observed tubular injury and extensive mononuclear cell infiltration.	Creatinine	118-128	serine (or cysteine) peptidase inhibitor, clade B, member 9	Mus musculus	0-5
24983310-6	2014	RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury.	Creatinine	125-135	CD47 molecule	Homo sapiens	9-13
24923577-7	2014	Higher urinary KIM-1/creatinine (from 24-hour urine collections) was associated with a higher risk for cardiovascular mortality (hazard ratio per SD increase, 1.27; 95% confidence interval [95% CI], 1.05 to 1.54; P=0.01).	Creatinine	21-31	hepatitis A virus cellular receptor 1	Homo sapiens	15-20
25071398-4	2014	In this study, we evaluated the associations between IL18 polymorphisms and graft function assessed by creatinine clearance in kidney transplant recipients.	Creatinine	103-113	interleukin 18	Homo sapiens	53-57
24467264-8	2014	Administration of kallistatin attenuated renal damage and decreased blood urea nitrogen and serum creatinine levels, but increased endothelial nitric oxide synthase and nitric oxide levels in the kidney.	Creatinine	98-108	serpin family A member 4	Homo sapiens	18-29
25142987-8	2014	The correlation analysis showed that serum CA125 level was positively associated with gender, HbA1c, glycated serum albumin, triglyceride, total cholesterol (P &lt; 0.05), but negatively with metformin and creatinine (P &lt; 0.01).	Creatinine	206-216	mucin 16, cell surface associated	Homo sapiens	43-48
24779676-6	2014	Urine NGAL levels were significantly increased during VOC vs ST (P = 0.007) and remained significant when normalized to urine creatinine (P = 0.004), while AER did not change significantly.	Creatinine	126-136	lipocalin 2	Homo sapiens	6-10
24235082-5	2014	In human studies, lipocalin 2 level was significantly associated with creatinine (r = 0.419, P &lt; 0.001) and negatively associated with eGFR (r = -0.365, P &lt; 0.001).	Creatinine	70-80	lipocalin 2	Homo sapiens	18-29
24582591-11	2014	Serum lipocalin-2 levels showed significant positive correlations with BMI and creatinine levels (P=0.002, and P=0.025, respectively).	Creatinine	79-89	lipocalin 2	Homo sapiens	6-17
24475761-6	2014	Correlation between P-/U-NGAL and plasma creatinine was weak.	Creatinine	41-51	lipocalin 2	Homo sapiens	25-29
24108204-8	2014	NGAL/creatinine ratio in pregnancy week 36-38 was significantly lower in preeclampsia than in healthy pregnant women or pregnant women with hypertension.	Creatinine	5-15	lipocalin 2	Homo sapiens	0-4
24262504-1	2014	BACKGROUND AND OBJECTIVES: Urine neutrophil gelatinase-associated lipocalin (uNGAL) has been shown to accurately predict and allow early detection of AKI, as assessed by an increase in serum creatinine in children and adults.	Creatinine	191-201	lipocalin 2	Homo sapiens	33-75
23532634-11	2014	However, the predictors of CFC, FCI, and DHEA-S levels were serum creatinine levels in hyperthyroidism, and both creatinine and transaminase levels in euthyroidism.	Creatinine	66-76	sulfotransferase family 2A member 1	Homo sapiens	41-47
24189322-6	2014	NQO1(-/-) mice showed increased blood urea nitrogen and creatinine levels, tubular damage, oxidative stress, and apoptosis.	Creatinine	56-66	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-4
24366512-8	2014	The temporal pattern of both urine neutrophil gelatinase-associated lipocalin absolute concentration elevation and normalized to urine creatinine concentration was correlated with the development of acute kidney injury and other clinical outcomes.	Creatinine	135-145	lipocalin 2	Homo sapiens	35-77
23984953-9	2013	Plasma creatinine and urea levels were significantly positively correlated with plasma gastrin, free acidity, and total acidity.	Creatinine	7-17	gastrin	Rattus norvegicus	87-94
23803723-4	2013	NGAL at entry was related to kidney function [r = 0.51 vs. creatinine (Cr) and r = -0.49 vs. estimated glomerular filtration rate (eGFR), both P &lt; 0.001], and weakly with hemoglobin (r = -0.36, P &lt; 0.05) and C-reactive protein (CRP) (r = 0.26, P &lt; 0.05).	Creatinine	59-69	lipocalin 2	Homo sapiens	0-4
23803723-4	2013	NGAL at entry was related to kidney function [r = 0.51 vs. creatinine (Cr) and r = -0.49 vs. estimated glomerular filtration rate (eGFR), both P &lt; 0.001], and weakly with hemoglobin (r = -0.36, P &lt; 0.05) and C-reactive protein (CRP) (r = 0.26, P &lt; 0.05).	Creatinine	71-73	lipocalin 2	Homo sapiens	0-4
23988168-8	2013	In this group, 27.3% (3/11) of the cases with normal serum creatinine level showed weakly positive KIM-1 expression in their renal tissues.	Creatinine	59-69	hepatitis A virus cellular receptor 1	Homo sapiens	99-104
23640503-12	2013	For those drugs which are predominantly eliminated by renal excretion, aging-related pharmacokinetic changes could be predicted by measuring creatinine clearance (CLCR).	Creatinine	141-151	chymotrypsin C	Homo sapiens	163-167
24941494-15	2013	NGAL correlated well (all with p&lt;0.001) with CysC (r=0.95), Cr (r=0.89), urea (r=0.76) and inversely with eGFR (r=-0.81).	Creatinine	63-65	lipocalin 2	Homo sapiens	0-4
23880804-6	2013	Urinary AM were measured on spot urine samples by high-performance liquid chromatography, and creatinine was measured by spectrophotometry to report the AM-creatinine ratio.	Creatinine	156-166	adrenomedullin	Homo sapiens	153-155
23880804-7	2013	RESULTS: Urinary AM-creatinine ratios were 61.3 +/- 119.4 pg/mg and 4.26 +/- 11.4 pg/mg, respectively, in the case and control groups (P = .01).	Creatinine	20-30	adrenomedullin	Homo sapiens	17-19
23953534-6	2013	Creatinine concentrations in the first month after transplantation differed between the rs5498 ICAM1 genotypes (P = .095), being higher for GG carriers (AA + AG vs GG, P =.07) albeit not with statistical significance.	Creatinine	0-10	intercellular adhesion molecule 1	Homo sapiens	95-100
23953534-7	2013	Creatinine concentrations at 12, 24, and 36 months after transplantation differed significantly among rs5498 ICAM1 genotypes (P = .0046, P =.016, and P = .02) and were higher among GG carriers (AA + AG vs GG, P = .001, P = .004, and P = .006).	Creatinine	0-10	intercellular adhesion molecule 1	Homo sapiens	109-114
23953534-8	2013	Rs5498 ICAM1 GG genotype and receipient male gender were independent factors associated with higher creatinine concentrations.	Creatinine	100-110	intercellular adhesion molecule 1	Homo sapiens	7-12
23866275-10	2013	In both groups, urinary NGAL/Cr ratio was positively correlated with urinary protein/Cr ratio (r = 0.510, P &lt; 0.01).	Creatinine	85-87	lipocalin 2	Homo sapiens	24-28
23866275-11	2013	The results of ROC curve analysis showed when diagnostic cut-off point of urinary NGAL/Cr was 0.043 by 3 weeks after treatment, sensitivity and specificity achieved 100% and 79.2% respectively.	Creatinine	87-89	lipocalin 2	Homo sapiens	82-86
23684135-8	2013	Urinary NGAL levels independently predicted AKI 12 hours after cisplatin (p=0.045) after adjustments for age, gender, body mass index, baseline serum creatinine, and urinary total protein.	Creatinine	150-160	lipocalin 2	Homo sapiens	8-12
23085062-10	2013	Urinary NGAL correlated with the serum creatinine increase and ischemia duration.	Creatinine	39-49	lipocalin 2	Homo sapiens	8-12
23085062-11	2013	Compared with patients without significantly increased serum creatinine, those with significantly increased serum creatinine after nephron sparing surgery had a greater increase in urinary NGAL but not in KIM-1.	Creatinine	114-124	lipocalin 2	Homo sapiens	189-193
23554037-8	2013	Urinary NGAL was significantly predictive of class III and IV LN (P=0.005) with 91% sensitivity and 70% specificity to levels &gt;= 10.07 ng/mg creatinine.	Creatinine	144-154	lipocalin 2	Homo sapiens	8-12
23461511-3	2013	Treatment of hydrides OsHCl(CO)(PPh3)2L (2), first with triflic acid and then with an excess of RN3 afforded organic azide complexes [OsCl(eta(1)-N3R)(CO)(PPh3)2L]BPh4 (5-7) [R = 4-CH3C6H4CH2, C6H5CH2, C6H5; L = P(OEt)3].	Creatinine	13-21	drosha ribonuclease III	Homo sapiens	96-99
23297176-2	2013	Data mining analysis generated a predictive model for anemia (hemoglobin (Hb) concentration &lt;10 g/dl); the CC genotype of ITPA, baseline Hb &lt;14.0 g/dl, and low creatinine clearance (CLcr) were predictors of anemia.	Creatinine	166-176	inosine triphosphatase	Homo sapiens	125-129
23498789-12	2013	In addition, FSP and CCL21 expression positively correlated with serum creatinine levels.	Creatinine	71-81	C-X-C motif chemokine ligand 1	Homo sapiens	13-16
23116596-6	2013	Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group.	Creatinine	61-71	NPHS1 adhesion molecule, nephrin	Homo sapiens	6-13
23823933-8	2013	Bis-1,4-DHP had a tendency to decrease hyperglycemia vs. diabetic rats, even though glycemia was too high as compared with controls, and it ameliorated albuminuria, creatinine, and urea excretion, suggesting a favorable effect on renal haemodynamics.	Creatinine	165-175	dihydropyrimidinase	Rattus norvegicus	8-11
22406119-7	2013	FGF23 was associated with serum phosphate (r = 0.24, P = .03) and creatinine clearance (r = -0.4, P = .001), but not with dietary phosphorus or 24-hour urinary phosphate excretion (P &gt; .05 for both).	Creatinine	66-76	fibroblast growth factor 23	Homo sapiens	0-5
23174241-10	2013	In patients with overactive bladder the nerve growth factor-to-creatinine (mean +- SD 488.5 +- 591.8 vs 188.3 +- 290.2, p = 0.005) and brain-derived neurotrophic factor-to-creatinine (mean 628.1 +- 590.5 vs 110.4 +- 159.5, p &lt;0.001) ratios were significantly higher than in healthy women.	Creatinine	172-182	brain derived neurotrophic factor	Homo sapiens	135-168
23174241-12	2013	After lifestyle intervention the nerve growth factor-to-creatinine and brain-derived neurotrophic factor-to-creatinine ratios decreased to a mean of 319.7 +- 332.3 and 432.5 +- 589.0 (vs baseline p = 0.318 and 0.033, respectively).	Creatinine	108-118	brain derived neurotrophic factor	Homo sapiens	71-104
23174241-13	2013	After antimuscarinic treatment the nerve growth factor-to-creatinine and brain-derived neurotrophic factor-to-creatinine ratios further decreased to a mean of 179.8 +- 237.9 and 146.6 +- 264.9 (vs baseline p = 0.008 and &lt;0.001, respectively).	Creatinine	110-120	brain derived neurotrophic factor	Homo sapiens	73-106
23174241-15	2013	The reduction in the number of urgency episodes per week correlated with the brain-derived neurotrophic factor-to-creatinine variation (Pearson product-moment correlation coefficient r = 0.607, p = 0.006) but not with the nerve growth factor-to-creatinine ratio (r = 0.396, p = 0.094).	Creatinine	114-124	brain derived neurotrophic factor	Homo sapiens	77-110
23174241-16	2013	CONCLUSIONS: The urinary nerve growth factor-to-creatinine and brain-derived neurotrophic factor-to-creatinine ratios are increased in patients with overactive bladder.	Creatinine	100-110	brain derived neurotrophic factor	Homo sapiens	63-96
23028104-8	2013	Serum levels of blood urea nitrogen and creatinine and urinary excretion levels of albumin and N-acetyl-beta-D-glucosaminidase were significantly elevated in diabetic MMP-2 KO mice when compared with wild-type diabetic littermates.	Creatinine	40-50	matrix metallopeptidase 2	Mus musculus	167-172
24327976-5	2013	RESULTS: The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P&lt;0.05 for both).	Creatinine	132-142	NPHS1 adhesion molecule, nephrin	Homo sapiens	31-38
23469304-8	2013	Moreover, the frequency of epitope-specific CD8(+) T cells at acute stage was inversely associated with the peak level of serum creatinine and was positively associated with the nadir platelet counts during the hospitalization.	Creatinine	128-138	CD8a molecule	Homo sapiens	44-47
24052978-2	2013	Early neutrophil gelatinase-associated lipocalin (NGAL) measurements can identify patients with sub-clinical AKI who have an increased risk of adverse outcomes, even in the absence of diagnostic increases in serum creatinine.	Creatinine	214-224	lipocalin 2	Homo sapiens	50-54
23200959-6	2013	RESULTS: Urine geometric mean KIM-1 levels (ng/mg creatinine) were significantly higher in VUR patients than in healthy controls (P=.018).	Creatinine	50-60	hepatitis A virus cellular receptor 1	Homo sapiens	30-35
22945466-4	2012	When NCX is added into this dimer, the interaction energy of the iodine-hydride interaction is increased by 9-45 % and its increased percentage follows the order X=Cl&lt;Br&lt;H&lt;I&lt;Li and M=Be&lt;Mg.	Creatinine	72-79	T cell leukemia homeobox 2	Homo sapiens	5-8
22946754-6	2012	In addition, the change in creatinine clearance, but not inulin clearance, significantly favored agalsidase alfa versus placebo recipients.	Creatinine	27-37	galactosidase alpha	Homo sapiens	97-112
22457086-3	2012	Serum levels of soluble alpha-Klotho in chronic kidney disease (CKD) patients have not previously been determined, especially in relation with FGF23 and creatinine levels.	Creatinine	153-163	klotho	Homo sapiens	30-36
22457086-9	2012	RESULTS: Serum soluble alpha-Klotho levels were associated positively with estimated glomerular filtration rate (eGFR) (P &lt; 0.0001) and inversely with serum creatinine level (P &lt; 0.01).	Creatinine	160-170	klotho	Homo sapiens	29-35
22457086-11	2012	Serum FGF23 levels were associated positively with serum creatinine and negatively with eGFR.	Creatinine	57-67	fibroblast growth factor 23	Homo sapiens	6-11
22718188-4	2012	Both the urine KIM-1 and Gpnmb to creatinine ratios correlated with the urinary albumin to creatinine ratio, the duration of diabetes, and the stringency of glycemic control but not with blood pressure or baseline eGFR.	Creatinine	91-101	hepatitis A virus cellular receptor 1	Homo sapiens	15-20
22967278-11	2012	CONCLUSIONS: In patients with liver cirrhosis, elevated systemic IL-22 levels are predictive for reduced survival independently from age, liver-related complications, CRP, creatinine and the MELD score.	Creatinine	172-182	interleukin 22	Homo sapiens	65-70
23211202-12	2012	Creatinine and urea mean concentrations were significantly lower both in IRI+HES (23.08 micromol/L and 8.38 mmol/L, respectively) and IRI + HS (26.59 micromol/L and 7.82 mmol/L) when compared to IRI (40.101 micromol/L and 11.25 mmol/L).	Creatinine	0-10	ataxia, cerebellar, Cayman type	Mus musculus	77-80
22739108-6	2012	Streptozotocin-induced diabetic manifestations were attenuated in sEH-deficient mice relative to wild-type controls, with significantly decreased levels of Hb A(1c), creatinine, and blood urea nitrogen and urinary microalbumin excretion.	Creatinine	166-176	epoxide hydrolase 2, cytoplasmic	Mus musculus	66-69
22373875-7	2012	In multivariable Cox analysis, adjusted for age, NT-proBNP, diastolic blood pressure, body mass index (BMI), haemoglobin and creatinine levels, C3a was a significant predictor of HF-related re-hospitalization or death (HR 1.189 per 1-SD increase, 95% CI 1.023-1.383), and of cardiovascular events or death (HR 1.302, CI 1.083-1.566).	Creatinine	125-135	complement C3	Homo sapiens	144-147
22452701-6	2012	In multiple regression analysis, soluble Klotho was associated with GH after correction for age, gender and levels of creatinine and phosphate (P = 0.029).	Creatinine	118-128	klotho	Homo sapiens	41-47
22270186-14	2012	Higher creatinine generation compared with CKD subjects may contribute to the underestimation of GFR by the Japanese GFR equation in potential kidney donors.	Creatinine	7-17	Rap guanine nucleotide exchange factor 5	Homo sapiens	97-100
22270186-14	2012	Higher creatinine generation compared with CKD subjects may contribute to the underestimation of GFR by the Japanese GFR equation in potential kidney donors.	Creatinine	7-17	Rap guanine nucleotide exchange factor 5	Homo sapiens	117-120
22150123-7	2012	FGF-23 (ln) predicted all-cause mortality (hazard ratio (HR) 5 042, P = 0 032) in a model adjusted for age, gender, estimated creatinine clearance, LVEF, New York Heart Association (NYHA) stage and NTproBNP level.	Creatinine	126-136	fibroblast growth factor 23	Homo sapiens	0-6
21791968-7	2012	Furthermore, circulating ZAG was positively correlated to systolic and diastolic blood pressure, creatinine, triglycerides, and leptin in univariate analyses.	Creatinine	97-107	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	25-28
21791968-8	2012	In multiple regression analysis, creatinine remained independently associated with ZAG.	Creatinine	33-43	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	83-86
22414856-4	2012	EET hydrolysis was significantly reduced in Ephx2(-/-) mice and was associated with an attenuation of cisplatin-induced increases in serum urea nitrogen and creatinine levels.	Creatinine	157-167	epoxide hydrolase 2, cytoplasmic	Mus musculus	44-49
22951846-8	2012	Spearman correlation analysis in the whole group indicated that CA 125 was positively correlated with aortic mean gradient (p=0.007, r=0.30) and creatinine levels (p=0.02, r=0.26).	Creatinine	145-155	mucin 16, cell surface associated	Homo sapiens	64-70
22951846-9	2012	CONCLUSION: We found that CA 125 levels were elevated in patients with AS and were correlated with mean gradient and creatinine levels.	Creatinine	117-127	mucin 16, cell surface associated	Homo sapiens	26-32
22661997-8	2012	Significant correlations were found between NGAL and creatinine at different time intervals.	Creatinine	53-63	lipocalin 2	Homo sapiens	44-48
21824169-9	2012	Moreover, the expression of alpha-SMA, fibronectin and MMP-9 mRNA correlated with serum creatinine levels (r = 0 514, r = 0 53 and r = 0 469, all P &lt; 0 001) and GFR levels (r = -0 374, r = -0 392 and r = -0 487, all P &lt; 0 01).	Creatinine	88-98	matrix metallopeptidase 9	Homo sapiens	55-60
22049183-7	2012	RESULTS: At Day 3, serum creatinine and albuminuria were lower after cRGD compared to cRAD treatment.	Creatinine	25-35	retinol dehydrogenase 16	Mus musculus	86-90
22628337-12	2012	Furthermore, there is a significant positive correlation between serum concentrations of KLK6 and creatinine (p&lt;0.0001), in patients with renal failure.	Creatinine	98-108	kallikrein related peptidase 6	Homo sapiens	89-93
22421304-7	2012	In models adjusted for traditional CVD risk factors and creatinine clearance, NGAL was a significant predictor of CVD mortality (hazard ratio [HR] per SD log increase: 1.33, 95% confidence interval [CI]: 1.12 to 1.57), all-cause mortality (HR: 1.19, 95% CI: 1.07 to 1.32), and a combined cardiovascular endpoint (HR: 1.26, 95% CI: 1.10 to 1.45).	Creatinine	56-66	lipocalin 2	Homo sapiens	78-82
22962220-1	2012	BACKGROUND: The Schwartz 2009 creatinine-based revised formula is the only pediatric GFR estimating formula, which is compatible with the recent global creatinine standardization.	Creatinine	30-40	Rap guanine nucleotide exchange factor 5	Homo sapiens	85-88
22962220-3	2012	We propose an equation, taking into account the relative bias caused by serum proteins to use Jaffe based creatinine data for GFR estimation.	Creatinine	106-116	Rap guanine nucleotide exchange factor 5	Homo sapiens	126-129
22371904-10	2012	A significant positive relationship was found between NGAL level and creatinine level in patients with normal basal leukocyte levels but not in those with higher leukocytes.	Creatinine	69-79	lipocalin 2	Homo sapiens	54-58
22466910-5	2012	Changes in serum creatinine and estimated GFR to month 12 were significantly in favor of CNI-free patients.	Creatinine	17-27	calcineurin binding protein 1	Homo sapiens	89-92
22971483-4	2012	RESULTS: RBP4 concentration was independently associated with gender, systolic blood pressure, serum triglyceride and creatinine levels, and estimated glomerular filtration rate (eGFR).	Creatinine	118-128	retinol binding protein 4	Homo sapiens	9-13
22876548-4	2012	Urine NGAL levels were found to be correlated with albumin/creatinine ratio (r = 0.452, p = 0.002), whereas plasma NGAL levels were correlated with nighttime systolic BP load (r = 0.309, p = 0.037).	Creatinine	59-69	lipocalin 2	Homo sapiens	6-10
23182776-7	2012	In some individuals normalizing urinary NGAL for urinary creatinine attenuated elevations.	Creatinine	57-67	lipocalin 2	Homo sapiens	40-44
23118991-4	2012	MMS19L might be associated with the adverse events of chemotherapy in NSCLC, especially for all grade leucopenia (P = 0.020), all grade jaundice (P = 0.037) and all grade creatinine increasing (P = 0.013).	Creatinine	171-181	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	0-6
22937100-5	2012	When adjusted for potential confounders, the treatment effect of gentamicin remained significant only for KIM-1 (mean difference from not treated, 1.35 ng/mg urinary creatinine; 95% CI 0.05-2.65).	Creatinine	166-176	hepatitis A virus cellular receptor 1	Homo sapiens	106-111
22523590-8	2012	Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification.	Creatinine	117-127	GATA binding protein 3	Homo sapiens	38-44
22583316-5	2012	Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients.	Creatinine	307-317	phospholipase A2 group VII	Homo sapiens	0-7
23013219-9	2012	Furthermore, rat transplanted with EPCs transfected with TERT showed significantly reduced renal interstitial fibrosis and increased endogenous creatinine clearance rate and peritubular MVD (p &lt; 0.05).	Creatinine	144-154	telomerase reverse transcriptase	Rattus norvegicus	57-61
22547995-3	2012	In the final model, there was a linear relationship between vancomycin clearance, CL (L/h), and creatinine clearance calculated by Cockcroft-Gault equation, CL(Cr) (mL/min): CL = 0.044 x L(Cr).	Creatinine	96-106	chymotrypsin C	Homo sapiens	157-163
21923802-8	2012	Urinary AGT-creatinine ratio (UAGT/UCre) was significantly higher in hypertensive patients compared with the normotensives (8.98 +- 6.89 mug/g vs. 5.48 +- 3.33 mug/g; P = 0.037).	Creatinine	12-22	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	30-34
21791552-6	2011	Regression analysis revealed that CD34+, CD34+/KDR+ and CD34+/CD45- hematopoietic CPCs were associated positively with eGFR and negatively with blood urea nitrogen and serum creatinine.	Creatinine	174-184	protein tyrosine phosphatase receptor type C	Homo sapiens	62-66
21791552-7	2011	The CD45+/KDR+ myeloid CPCs also were associated positively with eGFR and negatively with serum creatinine.	Creatinine	96-106	protein tyrosine phosphatase receptor type C	Homo sapiens	4-8
21791552-7	2011	The CD45+/KDR+ myeloid CPCs also were associated positively with eGFR and negatively with serum creatinine.	Creatinine	96-106	kinase insert domain receptor	Homo sapiens	10-13
21611756-3	2011	Our recent research provides novel molecular and functional evidence that indoxyl sulfate, an anionic uremic toxin, undergoes efflux transport at the BBB via OAT3 and creatinine, a uremic guanidino compound, undergoes efflux transport at the BCSFB via OCT3.	Creatinine	167-177	solute carrier family 22 member 3	Homo sapiens	252-256
21737852-8	2011	CONCLUSIONS: Clinical presentation influences the estimation of GFR from serum creatinine, and neither the CKD-EPI nor MDRD equation account for this.	Creatinine	79-89	Rap guanine nucleotide exchange factor 5	Homo sapiens	64-67
21606051-5	2011	In the early neonatal period, NGAL was positively correlated to baseline serum creatinine (r=0.47; P=0.02).	Creatinine	79-89	lipocalin 2	Homo sapiens	30-34
21606051-6	2011	In patients aged more than 10 days, plasma NGAL was correlated to peak serum creatinine in the postoperative course (r=0.21; P=0.003), and to the severity of acute kidney injury (r=0.15; P=0.032).	Creatinine	77-87	lipocalin 2	Homo sapiens	43-47
21257679-7	2011	RESULTS: Urinary NGAL/urine creatinine ratio was low prior to surgery and increased immediately after reperfusion, peaked 3 h later and remained elevated at 18 and 24 h. Urinary NGAL/urine creatinine ratios were higher in patients with post-operative (post-OP) AKI defined by RIFLE--risk criteria 3 and 18 h after reperfusion.	Creatinine	28-38	lipocalin 2	Homo sapiens	178-182
21257679-7	2011	RESULTS: Urinary NGAL/urine creatinine ratio was low prior to surgery and increased immediately after reperfusion, peaked 3 h later and remained elevated at 18 and 24 h. Urinary NGAL/urine creatinine ratios were higher in patients with post-operative (post-OP) AKI defined by RIFLE--risk criteria 3 and 18 h after reperfusion.	Creatinine	189-199	lipocalin 2	Homo sapiens	17-21
21257679-9	2011	CONCLUSIONS: We conclude that urinary NGAL/urine creatinine ratio is able to predict post-OP AKI 3 and 18 h after transplantation with good discrimination.	Creatinine	49-59	lipocalin 2	Homo sapiens	38-42
20966122-7	2011	RESULTS: At baseline, serum FGF-23 showed a significant association with serum creatinine, intact parathyroid hormone, proteinuria, urinary fractional excretion of phosphate, male sex, and race.	Creatinine	79-89	fibroblast growth factor 23	Homo sapiens	28-34
20966122-10	2011	Cox regression showed that FGF-23 was an independent predictor of the primary outcome, even after adjustment for creatinine clearance and intact parathyroid hormone (10 pg/ml FGF-23 increase = hazard ratio, 1.09; 95% CI, 1.01 to 1.16, P=0.02).	Creatinine	113-123	fibroblast growth factor 23	Homo sapiens	27-33
21042828-10	2011	In the CAM group, the changes of serum creatinine also showed a significant positive correlation with those of urinary ACR, urinary MCP-1, urinary IL-18 and serum levels of soluble ICAM-1.	Creatinine	39-49	interleukin 18	Homo sapiens	147-152
21042828-10	2011	In the CAM group, the changes of serum creatinine also showed a significant positive correlation with those of urinary ACR, urinary MCP-1, urinary IL-18 and serum levels of soluble ICAM-1.	Creatinine	39-49	intercellular adhesion molecule 1	Homo sapiens	181-187
21164037-6	2011	GDF-15 was positively correlated with age, waist-to-height ratio, mean arterial blood pressure, triglycerides, creatinine, glucose, insulin, C-peptide, hemoglobin A(1c), and homeostatic model assessment insulin resistance index and negatively correlated with oral glucose insulin sensitivity.	Creatinine	111-121	growth differentiation factor 15	Homo sapiens	0-6
21164037-7	2011	Age, homeostatic model assessment index, oral glucose insulin sensitivity, and creatinine were independent predictors of GDF-15 concentrations.	Creatinine	79-89	growth differentiation factor 15	Homo sapiens	121-127
21164037-9	2011	CONCLUSIONS: The associations between circulating GDF-15 concentrations and age, insulin resistance, and creatinine might account for the additional cardiovascular predictive information of GDF-15 compared to traditional risk factors.	Creatinine	105-115	growth differentiation factor 15	Homo sapiens	50-56
21164037-9	2011	CONCLUSIONS: The associations between circulating GDF-15 concentrations and age, insulin resistance, and creatinine might account for the additional cardiovascular predictive information of GDF-15 compared to traditional risk factors.	Creatinine	105-115	growth differentiation factor 15	Homo sapiens	190-196
21144611-8	2011	Serum chemerin was positively correlated with age, body mass index (BMI), systolic blood pressure (SBP), C-reactive protein (CRP), blood urea nitrogen (BUN), serum creatinine and serum triglycerides, and negatively correlated with creatinine clearance Stepwise regression analysis showed that creatinine clearance and serum creatinine remained significantly associated with serum chemerin.	Creatinine	164-174	retinoic acid receptor responder 2	Homo sapiens	6-14
21144611-8	2011	Serum chemerin was positively correlated with age, body mass index (BMI), systolic blood pressure (SBP), C-reactive protein (CRP), blood urea nitrogen (BUN), serum creatinine and serum triglycerides, and negatively correlated with creatinine clearance Stepwise regression analysis showed that creatinine clearance and serum creatinine remained significantly associated with serum chemerin.	Creatinine	231-241	retinoic acid receptor responder 2	Homo sapiens	6-14
21144611-8	2011	Serum chemerin was positively correlated with age, body mass index (BMI), systolic blood pressure (SBP), C-reactive protein (CRP), blood urea nitrogen (BUN), serum creatinine and serum triglycerides, and negatively correlated with creatinine clearance Stepwise regression analysis showed that creatinine clearance and serum creatinine remained significantly associated with serum chemerin.	Creatinine	231-241	retinoic acid receptor responder 2	Homo sapiens	6-14
21144611-8	2011	Serum chemerin was positively correlated with age, body mass index (BMI), systolic blood pressure (SBP), C-reactive protein (CRP), blood urea nitrogen (BUN), serum creatinine and serum triglycerides, and negatively correlated with creatinine clearance Stepwise regression analysis showed that creatinine clearance and serum creatinine remained significantly associated with serum chemerin.	Creatinine	231-241	retinoic acid receptor responder 2	Homo sapiens	6-14
21176857-6	2011	RBP4 correlated positively with triglycerides (p=0.001), log creatinine (p=0.009), and negatively with MDRD-GFR (p=0.04).	Creatinine	61-71	retinol binding protein 4	Homo sapiens	0-4
21176857-7	2011	In regression analysis, log A-FABP4 was associated with age, sex, log BMI, and log AER (r(2)=0.43) and RBP4 was associated with triglycerides and log creatinine (r(2)=0.22).	Creatinine	150-160	retinol binding protein 4	Homo sapiens	103-107
21233716-6	2011	After at least 6 months of idursulfase, urine glycosaminoglycan levels decreased from 592 +- 188 to 218 +- 115 mug/mg creatinine (P &lt; 0.0001, n = 34).	Creatinine	118-128	iduronate 2-sulfatase	Homo sapiens	27-38
20661225-10	2011	The number of renal F4/80+ macrophages was 10-fold higher in the CAST(-/-)ApoE(-/-) mice (P&lt;0.05), and was associated with a significantly higher level of alphaSMA+ cells, increased GBM/TBM destruction, and higher serum creatinine levels.	Creatinine	223-233	adhesion G protein-coupled receptor E1	Mus musculus	20-25
21952467-7	2011	RESULTS: A positive correlation between CD68 macrophage infiltration and serum creatinine concentration at presentation was identified.	Creatinine	79-89	CD68 molecule	Homo sapiens	40-44
20688351-9	2010	Furthermore, the serum creatinine levels and changes in serum creatinine from the previous year were significantly correlated with the total tubulointerstitial phosphorylated c-Jun-positive score (representing the number of positive nuclei in the tubules, interstitium, and peritubular capillaries).	Creatinine	23-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
20688351-9	2010	Furthermore, the serum creatinine levels and changes in serum creatinine from the previous year were significantly correlated with the total tubulointerstitial phosphorylated c-Jun-positive score (representing the number of positive nuclei in the tubules, interstitium, and peritubular capillaries).	Creatinine	62-72	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
21057332-13	2010	Similarly, plasma levels of lactate, creatinine, and tumor necrosis factor-alpha were also decreased by 42%, 28%, and 46% after human AM/AMBP-1 treatment, respectively.	Creatinine	37-47	complement factor H	Homo sapiens	137-143
20529972-1	2010	UNLABELLED: The present work aimed to prove the usage of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for kidney injury and to assess the relationship between NGAL and serum creatinine and cystatin C in patients with normal serum creatinine undergoing percutaneous coronary angiography.	Creatinine	201-211	lipocalin 2	Homo sapiens	186-190
20529972-1	2010	UNLABELLED: The present work aimed to prove the usage of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for kidney injury and to assess the relationship between NGAL and serum creatinine and cystatin C in patients with normal serum creatinine undergoing percutaneous coronary angiography.	Creatinine	257-267	lipocalin 2	Homo sapiens	101-105
20529972-6	2010	Before coronary angiography, serum NGAL was positively correlated with serum creatinine, and cystatin C.	Creatinine	77-87	lipocalin 2	Homo sapiens	35-39
20934567-8	2010	Heart rate, creatinine clearance, use of diuretics, and the presence of right ventricular hypokinesis were independently associated with ST2 levels.	Creatinine	12-22	ST2	Homo sapiens	137-140
20495108-9	2010	NGAL levels were bivariately associated with age, smoking, body composition, Charlson comorbidity score, neutrophil blood count, creatinine, and C-reactive protein but were significantly elevated in patients with COPD, even after adjustment for confounders.	Creatinine	129-139	lipocalin 2	Homo sapiens	0-4
20671216-8	2010	Two weeks after nephrectomy, the albumin-creatinine ratio of EP4(pod+) mice (3438 mug/mg) was significantly higher than that of non-TG mice (773 mug/mg; P &lt; 0.0001).	Creatinine	41-51	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	61-64
20671216-10	2010	In contrast, 6 weeks after nephrectomy, the albumin-creatinine ratio of EP4(pod-/-) mice (753 mug/mg) was significantly lower than that of non-TG mice (2516 mug/mg; P &lt; 0.05).	Creatinine	52-62	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	72-75
20208456-7	2010	Furthermore, circulating lipocalin 2 correlated positively with diastolic blood pressure, creatinine, and C reactive protein.	Creatinine	90-100	lipocalin 2	Homo sapiens	25-36
20208456-8	2010	In multivariate analyses, creatinine and C reactive protein remained independently associated with lipocalin-2 levels.	Creatinine	26-36	lipocalin 2	Homo sapiens	99-110
20671743-13	2010	ECM/BCM ratio correlated directly with age (r=0.38, P=0.002) and inversely with serum albumin (r=-0.43, P=0.001), creatinine (-0.24, P=0.08), blood urea nitrogen (r=-0.26, P=0.06), and total protein (r=-0.31, P=0.026).	Creatinine	114-124	TNF receptor superfamily member 17	Homo sapiens	4-7
20215390-4	2010	METHODS: GFR was estimated by using 11 different formulas based on creatinine, cystatin C and beta-trace protein.	Creatinine	67-77	Rap guanine nucleotide exchange factor 5	Homo sapiens	9-12
20402602-5	2010	We also wanted to evaluate if 24 h urine collection could be substituted by OX/creatinine-ratio (U-OX/crea) in spot-urine, and establish precursory reference intervals for U-OX/crea in children and adults.	Creatinine	79-89	urate oxidase (pseudogene)	Homo sapiens	97-101
20130785-4	2010	SMRP values increased with age 1.02-fold (95% CI 1.01-1.03) and serum creatinine concentration 1.32-fold (95% CI 1.20-1.45).	Creatinine	70-80	mesothelin	Homo sapiens	0-4
19807734-7	2010	The expression level of IL-17 was correlated closely with clinical parameters such as haematuria, blood urea nitrogen level, SLE Disease Activity Index scores in both glomeruli and interstitium, urine protein level in glomeruli and serum creatinine and creatinine clearance levels in interstitium.	Creatinine	238-248	interleukin 17A	Homo sapiens	24-29
19807734-7	2010	The expression level of IL-17 was correlated closely with clinical parameters such as haematuria, blood urea nitrogen level, SLE Disease Activity Index scores in both glomeruli and interstitium, urine protein level in glomeruli and serum creatinine and creatinine clearance levels in interstitium.	Creatinine	253-263	interleukin 17A	Homo sapiens	24-29
20507603-7	2010	Using logistic regression, four independent variables were associated with an elevated cTnI: previous coronary artery disease, Glasgow coma scale &lt;12, serum creatinine &gt;120 micromolxL-1, and heart rate &gt;110 bpm.	Creatinine	160-170	troponin I3, cardiac type	Homo sapiens	87-91
20424419-5	2010	Chemerin significantly and positively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) and serum creatinine in uni- and multivariate analyses.	Creatinine	125-135	retinoic acid receptor responder 2	Homo sapiens	0-8
20853600-2	2010	Arginase modulates levels of nitric oxide, creatine, and creatinine, likely by regulating intracellular L-arginine availability.	Creatinine	57-67	arginase 2	Homo sapiens	0-8
20413994-5	2010	A new equation to estimate GFR, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation, modestly improves accuracy from 80.6% of the Modification of Diet in Renal Disease eGFRs being within 30% of the measured GFR, to 84.1% of the CKD-EPI eGFRs being within 30% of the measured GFR.	Creatinine	96-106	Rap guanine nucleotide exchange factor 5	Homo sapiens	27-30
20413994-5	2010	A new equation to estimate GFR, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation, modestly improves accuracy from 80.6% of the Modification of Diet in Renal Disease eGFRs being within 30% of the measured GFR, to 84.1% of the CKD-EPI eGFRs being within 30% of the measured GFR.	Creatinine	96-106	Rap guanine nucleotide exchange factor 5	Homo sapiens	201-204
20413994-5	2010	A new equation to estimate GFR, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation, modestly improves accuracy from 80.6% of the Modification of Diet in Renal Disease eGFRs being within 30% of the measured GFR, to 84.1% of the CKD-EPI eGFRs being within 30% of the measured GFR.	Creatinine	96-106	Rap guanine nucleotide exchange factor 5	Homo sapiens	201-204
20424477-8	2010	In multiple regression analysis, residual renal function, hepcidin, creatinine and hsCRP were predictors of serum NGAL in haemodialysed patients.	Creatinine	68-78	lipocalin 2	Homo sapiens	114-118
19857721-0	2009	Plasma neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine, and glomerular filtration rate in patients after heart and lung transplantation.	Creatinine	93-103	lipocalin 2	Homo sapiens	7-49
19857721-0	2009	Plasma neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine, and glomerular filtration rate in patients after heart and lung transplantation.	Creatinine	93-103	lipocalin 2	Homo sapiens	51-55
19857721-2	2009	The aim of this work was to evaluate the utility of a new kidney damage marker-neutrophil gelatinase-associated lipocalin (NGAL)-and its correlations with cystatin C, creatinine, and glomerular filtration rate (GFR) among patients after heart or lung transplantation.	Creatinine	167-177	lipocalin 2	Homo sapiens	72-121
19857721-2	2009	The aim of this work was to evaluate the utility of a new kidney damage marker-neutrophil gelatinase-associated lipocalin (NGAL)-and its correlations with cystatin C, creatinine, and glomerular filtration rate (GFR) among patients after heart or lung transplantation.	Creatinine	167-177	lipocalin 2	Homo sapiens	123-127
19857721-5	2009	In the transplant group, serum NGAL positively correlated with serum creatinine (R = .27; P = .001).	Creatinine	69-79	lipocalin 2	Homo sapiens	31-35
19628673-5	2009	Urine neutrophil gelatinase-associated lipocalin remained independently associated with the development of AKI after adjustment for age, serum creatinine closest to enrollment, illness severity, sepsis, and intensive care unit (ICU) location, although it only marginally improved the predictive performance of the clinical model alone.	Creatinine	143-153	lipocalin 2	Homo sapiens	6-48
19559209-2	2009	METHODS: Using data from a prospective observational study of 100 adult cardiac surgical patients, we correlated early postoperative concentrations of plasma NGAL and serum cystatin C with the duration (time during which AKI persisted according to the Acute Kidney Injury Network criteria) and severity of AKI (change in serum creatinine) and with length of stay in intensive care.	Creatinine	327-337	lipocalin 2	Homo sapiens	158-162
19478100-9	2009	On univariate analysis, Pcl was negatively correlated with serum albumin and positively correlated with age, dialysate/plasma creatinine ratio (D/Pcr), the presence of peripheral vascular disease, and urine volume.	Creatinine	126-136	PHD finger protein 1	Homo sapiens	24-27
19673171-8	2009	NGAL increases in both serum and urine 48 hours before the rise of creatinine, and shows a strong correlation with change in creatinine concentrations.	Creatinine	67-77	lipocalin 2	Homo sapiens	0-4
19673171-8	2009	NGAL increases in both serum and urine 48 hours before the rise of creatinine, and shows a strong correlation with change in creatinine concentrations.	Creatinine	125-135	lipocalin 2	Homo sapiens	0-4
19508377-6	2009	The levels of urinary factor H, when expressed as a ratio of urinary creatinine, were significantly higher in groups 3 than group 1 and 2, also significantly higher in group 2 than group 1.	Creatinine	69-79	complement factor H	Homo sapiens	22-30
19426682-4	2009	[(14)C]TEA uptake by hOCT2, but not hOCT1, was trans-stimulated by unlabeled guanidine, methylguanidine, creatinine, aminoguanidine and phenylguanidine.	Creatinine	105-115	POU class 2 homeobox 2	Homo sapiens	21-26
19426682-5	2009	In patients with renal failure, the impairment of hOCT2 might decrease the excretion of guanidine, methylguanidine, and creatinine as uremic toxins.	Creatinine	120-130	POU class 2 homeobox 2	Homo sapiens	50-55
19426682-7	2009	Metformin, which was also an anti-diabetic agent, and creatinine more potently inhibited the uptake of [(14)C]aminoguanidine by hOCT2 than that by hOCT1.	Creatinine	54-64	POU class 2 homeobox 2	Homo sapiens	128-133
19352124-3	2009	CIT was correlated (r=0.43, P=0.003) with the time taken for creatinine concentration to fall to half the perioperative value (Crt(1/2)) but not with MCAi.	Creatinine	61-71	hyaluronan and proteoglycan link protein 1	Homo sapiens	127-134
19246724-3	2009	There is a clear correlation between the renal clearance of 5-HMT and creatinine clearance.	Creatinine	70-80	histamine N-methyltransferase	Homo sapiens	62-65
19167760-7	2009	The increased chemokine and chemokine receptor expression seen in the C3aR KO MRL mice was associated with a more rapid rise in serum creatinine and the acceleration of renal fibrosis.	Creatinine	134-144	complement component 3a receptor 1	Mus musculus	70-74
19188083-0	2009	Screening for X-linked creatine transporter (SLC6A8) deficiency via simultaneous determination of urinary creatine to creatinine ratio by tandem mass-spectrometry.	Creatinine	118-128	solute carrier family 6 member 8	Homo sapiens	45-51
19188083-1	2009	High urinary creatine to creatinine ratio (U-CrCrtR) is a potential diagnostic marker of X-linked creatine transporter (SLC6A8) deficiency.	Creatinine	25-35	solute carrier family 6 member 8	Homo sapiens	120-126
19185381-0	2009	The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.	Creatinine	168-178	presenilin associated rhomboid like	Homo sapiens	75-79
18753296-4	2008	IL-18BP Tg mice were functionally and histologically protected against ischemic AKI as determined by blood urea nitrogen, serum creatinine, and acute tubular necrosis score.	Creatinine	128-138	interleukin 18 binding protein	Mus musculus	0-7
18802933-8	2008	Serum AGEs and pre-beta-HDL were the significant independent determinants of ABCA1-mediated cholesterol efflux, whereas plasma HDL and log (creatinine) were the significant determinants of SR-BI-mediated cholesterol efflux.	Creatinine	140-150	scavenger receptor class B member 1	Homo sapiens	189-194
18442869-12	2008	CONCLUSION: In this study it was found that CL(VP16) is reduced in patients with elevated serum creatinine, whilst ifosfamide coadministration increases CL(VP16) and reduces AUC(VP16), demonstrating the interaction between VP16 and ifosfamide.	Creatinine	96-106	host cell factor C1	Homo sapiens	44-51
18442869-12	2008	CONCLUSION: In this study it was found that CL(VP16) is reduced in patients with elevated serum creatinine, whilst ifosfamide coadministration increases CL(VP16) and reduces AUC(VP16), demonstrating the interaction between VP16 and ifosfamide.	Creatinine	96-106	host cell factor C1	Homo sapiens	47-51
19010142-0	2008	Association between serum soluble CD30 and serum creatinine before and after renal transplantation.	Creatinine	49-59	TNF receptor superfamily member 8	Homo sapiens	34-38
18752646-4	2008	In contrast, the elimination clearance of CTN from the CSF was 60-fold greater than that of inulin, reflecting CSF bulk flow.	Creatinine	42-45	colony stimulating factor 2	Rattus norvegicus	55-58
18752646-4	2008	In contrast, the elimination clearance of CTN from the CSF was 60-fold greater than that of inulin, reflecting CSF bulk flow.	Creatinine	42-45	colony stimulating factor 2	Rattus norvegicus	111-114
18752646-5	2008	Even in renal failure model rats, the increasing ratio of the CTN concentration in the CSF was lower than that in the plasma, suggesting a significant role for the CSF-to-blood efflux process.	Creatinine	62-65	colony stimulating factor 2	Rattus norvegicus	87-90
18752646-5	2008	Even in renal failure model rats, the increasing ratio of the CTN concentration in the CSF was lower than that in the plasma, suggesting a significant role for the CSF-to-blood efflux process.	Creatinine	62-65	colony stimulating factor 2	Rattus norvegicus	164-167
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	26-29	colony stimulating factor 2	Rattus norvegicus	53-56
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	26-29	colony stimulating factor 2	Rattus norvegicus	74-77
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	117-120	colony stimulating factor 2	Rattus norvegicus	53-56
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	117-120	colony stimulating factor 2	Rattus norvegicus	74-77
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	117-120	colony stimulating factor 2	Rattus norvegicus	53-56
18752646-8	2008	Our findings suggest that CTN is eliminated from the CSF across the blood-CSF barrier as a major pathway of cerebral CTN clearance and transporter-mediated processes are involved in the CTN transport in the choroid plexus.	Creatinine	117-120	colony stimulating factor 2	Rattus norvegicus	74-77
25983985-9	2008	Cancer antigen (CA) 125 was highest in the short-term group (P &lt;= 0.02) and had a strong positive correlation with mass transfer area coefficient of creatinine (MTAC-creatinine) only in the short-term group (r = 0.62, P &lt;= 0.01).	Creatinine	152-162	mucin 16, cell surface associated	Homo sapiens	0-23
18649981-13	2008	CONCLUSIONS: Urinary NGAL has limited diagnostic accuracy to predict AKI defined by change in serum creatinine after cardiac surgery.	Creatinine	100-110	lipocalin 2	Homo sapiens	21-25
18513404-8	2008	Neostriatal and hippocampal monoamines were decreased at 7, 24, and 72 h, with a concurrent increase in GFAP at 72 h. There was no effect of MA on regional brain creatine, however plasma creatinine was increased during the first 24 h and decreased by 72 h. As with MA treatment, forced swim increased corticosterone more than MA initially.	Creatinine	187-197	glial fibrillary acidic protein	Rattus norvegicus	104-108
18275504-10	2008	Serum NGAL was related, in univariate analysis, to serum creatinine, urea, urinary NGAL, haemoglobin, haematocrit, duration of hypertension, age, eGFR by MDRD and Cockcroft-Gault, and cystatin C.	Creatinine	57-67	lipocalin 2	Homo sapiens	6-10
18023222-3	2008	Using this method, we studied the relationship between urinary levels of total Gb3/creatinine excretion and four types of mutations in the GLA gene (missense, nonsense, frameshift, and splice-site defects) in 32 children and 78 adult patients with Fabry disease.	Creatinine	83-93	galactosidase alpha	Homo sapiens	139-142
17996888-8	2008	RBP levels were expressed as RBP:creatinine (RBP:c) ratios following normalisation with urinary creatinine.	Creatinine	33-43	retinol binding protein 4	Homo sapiens	0-3
18924523-0	2008	[Estimation of GFR from serum creatinine and cystatin C-A comparison of 2 methods in patients with neurogenic bladder due to myelomeningocle (MMC)].	Creatinine	30-40	Rap guanine nucleotide exchange factor 5	Homo sapiens	15-18
18667845-8	2008	However, proGRP levels were significantly correlated with age, sex, creatinine concentrations, body mass index and smoking.	Creatinine	68-78	gastrin releasing peptide	Homo sapiens	9-15
18162987-4	2007	One possible explanation for this finding is the prolonged pretransplantation exposure to tacrolimus in the ABO-incompatible group, resulting in tacrolimus-associated renal toxicity, which slows the reduction in plasma creatinine.	Creatinine	219-229	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	108-111
18165774-10	2007	High KIM-1 excretion was associated with proteinuria, low creatinine clearance, and high donor age (all P&lt;0.01).	Creatinine	58-68	hepatitis A virus cellular receptor 1	Homo sapiens	5-10
18165774-11	2007	In multivariate Cox regression analyses, prediction of graft loss by KIM-1 appeared independent of creatinine clearance, proteinuria, and donor age.	Creatinine	99-109	hepatitis A virus cellular receptor 1	Homo sapiens	69-74
18037094-8	2007	Albumin and gamma-GT concentration and excretion (milligrams per gram of creatinine or units per gram creatinine) were significantly greater for girls compared with boys.	Creatinine	73-83	inactive glutathione hydrolase 2	Homo sapiens	12-20
17630267-6	2007	Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients.	Creatinine	19-29	retinol binding protein 4	Homo sapiens	54-59
17667987-6	2007	Heme oxygenase-1 induction prevented the increase in plasma creatinine and in superoxide in both the cortex and medulla compared to untreated rats with acute kidney injury.	Creatinine	60-70	heme oxygenase 1	Rattus norvegicus	0-16
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	167-177	glutathione S-transferase theta 1	Homo sapiens	0-5
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	279-289	glutathione S-transferase theta 1	Homo sapiens	0-5
17371819-7	2007	PEN renal clearance correlated with creatinine clearance (R(2) = 0.309596; P = 0.038).	Creatinine	36-46	pumilio RNA binding family member 3	Homo sapiens	0-3
17530720-6	2007	RESULTS: Among SLE patients, urinary lipocalin-2 levels were significantly higher in those with lupus nephritis (LN) (median 17.1 ng/mg creatinine, interquartile range [IQR] 10.3-45.4; n = 32) than in those without LN (median 11.2 ng/mg creatinine, IQR 3.1-20.3; n = 38) (P = 0.023).	Creatinine	136-146	lipocalin 2	Homo sapiens	37-48
17530720-6	2007	RESULTS: Among SLE patients, urinary lipocalin-2 levels were significantly higher in those with lupus nephritis (LN) (median 17.1 ng/mg creatinine, interquartile range [IQR] 10.3-45.4; n = 32) than in those without LN (median 11.2 ng/mg creatinine, IQR 3.1-20.3; n = 38) (P = 0.023).	Creatinine	237-247	lipocalin 2	Homo sapiens	37-48
17398109-8	2007	Preoperative basal CD11b expression showed a significant inverse relationship with postoperative creatinine levels.	Creatinine	97-107	integrin subunit alpha M	Homo sapiens	19-24
17664853-13	2007	In conclusion, high plasma NE at entry, associated with the Gly16 allele of the beta2-adrenoceptor polymorphisms, predict renal function deterioration (seen in elevations of BUN and creatinine and reduction of creatinine clearance) over a 5-year period accompanying further heightened sympathetic nerve activity and deterioration of insulin resistance.	Creatinine	182-192	adrenoceptor beta 2	Homo sapiens	80-98
17664853-13	2007	In conclusion, high plasma NE at entry, associated with the Gly16 allele of the beta2-adrenoceptor polymorphisms, predict renal function deterioration (seen in elevations of BUN and creatinine and reduction of creatinine clearance) over a 5-year period accompanying further heightened sympathetic nerve activity and deterioration of insulin resistance.	Creatinine	210-220	adrenoceptor beta 2	Homo sapiens	80-98
17397512-6	2007	In multiple regression analysis for each factor of model for end-stage liver disease (MELD) score, only IL-10 level was selected as the significant independent variable for total bilirubin level, only IL-17 level for prothrombin time, and TNF-alpha and IL-1beta levels for creatinine level.	Creatinine	273-283	interleukin 10	Homo sapiens	104-109
17394854-6	2007	sTNFRI, IL-1Ra and ICAM-1 early showed significantly higher levels in relation with serum creatinine, and these and also IL-6 in those with PO2 below 60 mmHg.	Creatinine	90-100	intercellular adhesion molecule 1	Homo sapiens	19-25
17347575-3	2007	eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits.	Creatinine	24-34	Rap guanine nucleotide exchange factor 5	Homo sapiens	1-4
17585540-5	2007	The correlative study was undertaken to evaluate the possible relationships between the immunoexpression of RANTES, the number of CCR5+ cells, the immunoexpression of TGF-beta1, alpha-SMA, the value of interstitial cortical volume and the serum creatinine level in patients with lupus nephropathy.	Creatinine	245-255	C-C motif chemokine ligand 5	Homo sapiens	108-114
17198276-11	2006	In comparison with control mice, serum levels of creatinine and BUN were also significantly decreased in C3 and caspase 3 siRNA-treated mice.	Creatinine	49-59	caspase 3	Mus musculus	112-121
17142982-4	2006	Oral clearance (CL/F) was modeled with creatinine clearance (CLcr), and the mean value was estimated to be 1.93.CLcr l/h.	Creatinine	39-49	chymotrypsin C	Homo sapiens	61-65
17061021-1	2006	OBJECTIVE: To explore the effects of renal function estimated by measured creatinine clearance (Cl(CR)) on trough serum concentration (C(min)) of piperacillin given to critically ill patients.	Creatinine	74-84	chymotrypsin C	Homo sapiens	96-102
17133564-2	2006	In this prospective, multicenter, randomized study, chronic CNI-related renal dysfunction was defined by an increase in serum creatinine with values &gt;140 micromol/L and &lt;300 micromol/L.	Creatinine	126-136	calcineurin binding protein 1	Homo sapiens	60-63
16868980-6	2006	Information on current markers of renal function and disease was obtained and compared with NGAL levels (ng/mg of urinary creatinine) measured by enzyme-linked immunosorbent assay.	Creatinine	122-132	lipocalin 2	Homo sapiens	92-96
16868980-11	2006	NGAL levels of &gt;0.6 ng/mg urinary creatinine were 90% sensitive and 100% specific for identifying childhood-onset SLE patients with biopsy-proven nephritis.	Creatinine	37-47	lipocalin 2	Homo sapiens	0-4
16827865-7	2006	By multivariate analysis, both urine NGAL and IL-18 on day 0 predicted the trend in serum creatinine in the posttransplant period after adjusting for effects of age, gender, race, urine output and cold ischemia time (p &lt; 0.01).	Creatinine	90-100	lipocalin 2	Homo sapiens	37-41
16827865-7	2006	By multivariate analysis, both urine NGAL and IL-18 on day 0 predicted the trend in serum creatinine in the posttransplant period after adjusting for effects of age, gender, race, urine output and cold ischemia time (p &lt; 0.01).	Creatinine	90-100	interleukin 18	Homo sapiens	46-51
16773412-11	2006	However, children with increased urinary NGAL levels had higher peak BUN and creatinine concentrations (P&lt;0.01) and required dialysis more often, 9/20 versus 1/14 (P=0.024) compared to children with normal excretion.	Creatinine	77-87	lipocalin 2	Homo sapiens	41-45
16756635-9	2006	In addition, urinary expression of RANTES had significant correlation with degree of proteinuria, serum creatinine, albumin and estimated glomerular filtration rate.	Creatinine	104-114	C-C motif chemokine ligand 5	Homo sapiens	35-41
16528543-8	2006	Importantly, NGAL staining in these early CAD biopsies was strongly correlated with peak postoperative serum creatinine, which occurred days later (R=0.86, p&lt;0.001).	Creatinine	109-119	lipocalin 2	Homo sapiens	13-17
16797290-5	2006	Urinary betaig-h3 excretion was higher in chronic CyAN compared to control subjects (173.4+/-26.0 vs 62.6+/-5.0 ng/mg creatinine, P&lt;.01).	Creatinine	118-128	transforming growth factor beta induced	Homo sapiens	8-17
16797290-9	2006	Urinary betaig-h3 levels decreased from 173.4+/-26.0 to 64.9+/-14.4 ng/mg creatinine at 1 month after discontinuation of CyA or reduction in CyA dosage (P&lt;.01) despite unchanged serum creatinine levels.	Creatinine	74-84	transforming growth factor beta induced	Homo sapiens	8-17
16572110-6	2006	IP-10 expression in urine identified patients with ongoing acute rejection episodes several days before a biopsy was indicated by rising serum creatinine levels.	Creatinine	143-153	C-X-C motif chemokine ligand 10	Homo sapiens	0-5
16381997-8	2006	FGF-23 levels were significantly correlated positively with serum corrected calcium and intact PTH levels, and negatively with creatinine clearance and inorganic phosphate, among which creatinine clearance and corrected calcium were independently associated factors.	Creatinine	127-137	fibroblast growth factor 23	Homo sapiens	0-6
16381997-8	2006	FGF-23 levels were significantly correlated positively with serum corrected calcium and intact PTH levels, and negatively with creatinine clearance and inorganic phosphate, among which creatinine clearance and corrected calcium were independently associated factors.	Creatinine	185-195	fibroblast growth factor 23	Homo sapiens	0-6
16408133-1	2006	Glomerular filtration rate (GFR) estimates from serum creatinine has not been generalizable across all populations.	Creatinine	54-64	Rap guanine nucleotide exchange factor 5	Homo sapiens	28-31
16408133-3	2006	The objective of this study was to compare cystatin C with serum creatinine for estimating GFR among different clinical presentations.	Creatinine	65-75	Rap guanine nucleotide exchange factor 5	Homo sapiens	91-94
16408133-6	2006	GFR was modeled using the following variables: cystatin C (or serum creatinine), age, gender and clinical presentation.	Creatinine	68-78	Rap guanine nucleotide exchange factor 5	Homo sapiens	0-3
16148039-9	2005	On multivariable analysis, urine IL-18 values predicted development of AKI 24 and 48 h later after adjustment for demographics, sepsis, Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) III score, serum creatinine, and urine output.	Creatinine	221-231	interleukin 18	Homo sapiens	33-38
15798956-2	2005	Polymorphisms G1704T and G82S of the RAGE gene were examined with genomic DNA obtained from 116 type 2 diabetic patients with microalbuminuria (urinary albumin/creatinine ratio between 30 and 300 mg/g of creatinine) (microalbuminuria group), and 232 patients with normoalbuminuria (urinary albumin/creatinine ratio &lt;30 mg/g of creatinine) (normoalbuminuria group).	Creatinine	160-170	long intergenic non-protein coding RNA 914	Homo sapiens	37-41
15615823-9	2005	This study also emphasizes the complexity of laboratory calibration of serum creatinine measurements, a determining factor when estimating GFR in both healthy individuals and CKD patients with preserved GFR.	Creatinine	77-87	Rap guanine nucleotide exchange factor 5	Homo sapiens	139-142
15615823-9	2005	This study also emphasizes the complexity of laboratory calibration of serum creatinine measurements, a determining factor when estimating GFR in both healthy individuals and CKD patients with preserved GFR.	Creatinine	77-87	Rap guanine nucleotide exchange factor 5	Homo sapiens	203-206
15996335-9	2005	As sTM is excreted by the kidney we also measured plasma level of creatinine and its clearance.	Creatinine	66-76	sulfotransferase family 1A member 3	Homo sapiens	3-6
15618069-5	2005	Lp-PLA2 levels correlated with male gender, LDL, HDL, and total cholesterol, fibrinogen, and creatinine.	Creatinine	93-103	phospholipase A2 group VII	Homo sapiens	0-7
15782993-13	2005	One patient with mild renal function impairment before surgery (ClCr=45.4mL/min) successfully recovered with 60% rise in creatinine clearance (ClCr=78.1mL/min) after the operation.	Creatinine	121-131	chymotrypsin C	Homo sapiens	64-68
15782993-13	2005	One patient with mild renal function impairment before surgery (ClCr=45.4mL/min) successfully recovered with 60% rise in creatinine clearance (ClCr=78.1mL/min) after the operation.	Creatinine	121-131	chymotrypsin C	Homo sapiens	143-147
15702404-5	2005	The levels of CTH and CDH were related to both creatinine and sphingomyelin.	Creatinine	47-57	choline dehydrogenase	Homo sapiens	22-25
15717636-7	2005	RESULTS: The mean CHr value of the nondialysis CRF patients (creatinine clearance less than 70 mL/min) was 32.3 pg, which was not significantly different from that of the dialysis patients.	Creatinine	61-71	chromate resistance; sulfate transport	Homo sapiens	18-21
15717636-9	2005	A positive correlation was observed between the CHr and serum creatinine levels.	Creatinine	62-72	chromate resistance; sulfate transport	Homo sapiens	48-51
15969265-6	2004	An average of 7,27 +/- 5,31 nM Dpd/mM creatinine was found.	Creatinine	38-48	dihydropyrimidine dehydrogenase	Homo sapiens	31-34
15509543-10	2004	Finally, increased collagen deposition is observed and serum creatinine levels are significantly increased in CnA-alpha -/- animals compared to wild-type littermates, indicating that kidney function is impaired.	Creatinine	61-71	protein phosphatase 3, catalytic subunit, alpha isoform	Mus musculus	110-113
15529388-9	2004	Furthermore, a significant correlation was found for the interstitial as well as for the glomerular infiltration of CD68-positive macrophages with serum creatinine concentration at the time of biopsy (P = 0.001 and P = 0.006, respectively).	Creatinine	153-163	CD68 molecule	Homo sapiens	116-120
15514586-8	2004	Anti-GBM glomerulonephritis was prevented from functionally deteriorating (eg, proteinuria or increasing serum creatinine) by CTLA4 immunoglobulin or anti-activation-inducible lymphocyte immunomodulatory molecule (AILIM) mAb as an anti-ICOS mAb.	Creatinine	111-121	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	126-131
15359983-0	2004	Methods of GFR determination--creatinine clearance after cimetidine administration in clinical practice.	Creatinine	30-40	Rap guanine nucleotide exchange factor 5	Homo sapiens	11-14
15171478-1	2004	An alginate microcapsule was developed that contains three enzymes (urease, uricase, and creatininase) capable of effectively degrading urea, uric acid, and creatinine, which are elevated to pathologic levels in patients with kidney failure.	Creatinine	157-167	urate oxidase (pseudogene)	Homo sapiens	76-83
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	111-121	interleukin 18	Homo sapiens	15-20
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	149-159	interleukin 18	Homo sapiens	15-20
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	149-159	interleukin 18	Homo sapiens	15-20
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	149-159	interleukin 18	Homo sapiens	15-20
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	149-159	interleukin 18	Homo sapiens	15-20
14981598-5	2004	Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P &lt;0.002).	Creatinine	149-159	interleukin 18	Homo sapiens	15-20
14981598-6	2004	In kidney transplant recipients, lower urinary IL-18 levels were associated with a steeper decline in serum creatinine concentrations postoperative days 0 to 4 (P = 0.009).	Creatinine	108-118	interleukin 18	Homo sapiens	47-52
15384786-8	2004	In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6.	Creatinine	27-37	mucin 16, cell surface associated	Homo sapiens	101-106
15331938-7	2004	The mean level of urinary factor H was elevated (86.30 +/- 21.93 U/mg urinary creatinine) in comparison to that of normal controls (4.76 +/- 1.03 U/mg urinary creatinine).	Creatinine	78-88	complement factor H	Homo sapiens	26-34
15331938-7	2004	The mean level of urinary factor H was elevated (86.30 +/- 21.93 U/mg urinary creatinine) in comparison to that of normal controls (4.76 +/- 1.03 U/mg urinary creatinine).	Creatinine	159-169	complement factor H	Homo sapiens	26-34
15331938-8	2004	Urinary factor H level exhibited no correlation with clinical parameters; however, a negative correlation was found between urinary C5b-9/factor H and creatinine clearance (r = 0.662, p &lt; 0.01).	Creatinine	151-161	complement factor H	Homo sapiens	138-146
15013310-7	2004	By the Spearman correlation test, CD44 expression did not correlate with Banff scores, but was moderately correlated with serum creatinine values at the time of biopsy (P =.017, r =.4).	Creatinine	128-138	CD44 molecule (Indian blood group)	Homo sapiens	34-38
14531809-9	2003	CONCLUSION: Renal nNOS abundance was reduced in the 5/6 A/I model of renal disease when plasma creatinine&gt; approximately 1 mg/dL and when&gt; approximately 20% of remaining glomeruli were sclerosed.	Creatinine	95-105	nitric oxide synthase 1	Rattus norvegicus	18-22
12955677-8	2003	Levels of urinary NHE3 normalized to urinary creatinine level were increased in patients with prerenal azotemia and 6 times as much in patients with ATN, without overlap (ATN, 0.78 +/- 0.36; prerenal azotemia, 0.12 +/- 0.08; P &lt; 0.001).	Creatinine	45-55	solute carrier family 9 member A3	Homo sapiens	18-22
12955677-10	2003	Normalized NHE3 level correlated positively with serum creatinine level in patients with tubular injury (R2 = 0.305; P = 0.0003).	Creatinine	55-65	solute carrier family 9 member A3	Homo sapiens	11-15
14509218-8	2003	The mean CHr value of the non-dialysis patients (creatinine clearance less than 70 ml/min) was 32.7 pg, which did not differ significantly from that of the dialysis patients.	Creatinine	49-59	chromate resistance; sulfate transport	Homo sapiens	9-12
14509218-11	2003	There was a positive correlation between CHr and serum creatinine levels.	Creatinine	55-65	chromate resistance; sulfate transport	Homo sapiens	41-44
12566693-5	2003	Interstitial ICAM-1+ leukocytes were correlated with glomerulosclerosis involving less and more than 50% of the glomerular area, tubular atrophy, interstitial fibrosis, and serum creatinine concentration (r = 0.6343, p &lt; 0.001).	Creatinine	179-189	intercellular adhesion molecule 1	Homo sapiens	13-19
12566693-6	2003	In patients with an increase of 50% in the serum creatinine concentration, interstitial ICAM-1+ leukocytes and CD14+ and CD3+ cells were significantly more numerous than in patients with a stable creatinine concentration.	Creatinine	49-59	intercellular adhesion molecule 1	Homo sapiens	88-94
12566693-6	2003	In patients with an increase of 50% in the serum creatinine concentration, interstitial ICAM-1+ leukocytes and CD14+ and CD3+ cells were significantly more numerous than in patients with a stable creatinine concentration.	Creatinine	196-206	intercellular adhesion molecule 1	Homo sapiens	88-94
12566693-7	2003	In patients with no glomerulonephritis, tubular ICAM-1+ was seen in 7 of 29 (24%) biopsy specimens, inversely correlated with the number of normal glomeruli and associated with glomerulosclerosis covering more than 50% of the glomerular area, tubular atrophy, and creatinine.	Creatinine	264-274	intercellular adhesion molecule 1	Homo sapiens	48-54
12566368-4	2003	METHODS AND RESULTS: Myocardial CNP production was determined (difference in plasma levels between the aortic root and coronary sinus [CS]) in 9 patients undergoing right and left heart catheterization as part of their CHF assessment (all male, age 59+/-9 years; New York Heart Association class 2.2+/-0.1; left ventricular ejection fraction 29+/-5%; creatinine 105+/-8 micro mol/L [all values mean+/-SEM]).	Creatinine	351-361	natriuretic peptide C	Homo sapiens	32-35
12397687-3	2002	In some experiments, adenovirus harboring mouse klotho gene(ad-klotho, 3.3 x 10(10) pfu) was intravenously administered immediately before starting angiotensin II infusion, and this resulted in an improvement of creatinine clearance, decrease in urinary protein excretion, and amelioration of tubulointerstitial damage induced by this octapeptitde.	Creatinine	212-222	klotho	Mus musculus	48-54
12003997-7	2002	Baseline albuminuria in the Daf1(-/-) mice was 115.9 +/- 41.4 microg/mg creatinine as compared with 85.7 +/- 32.3 microg/mg creatinine in their Daf1(+/+) littermates (p = 0.075).	Creatinine	72-82	CD55 molecule, decay accelerating factor for complement	Mus musculus	28-32
12003997-7	2002	Baseline albuminuria in the Daf1(-/-) mice was 115.9 +/- 41.4 microg/mg creatinine as compared with 85.7 +/- 32.3 microg/mg creatinine in their Daf1(+/+) littermates (p = 0.075).	Creatinine	124-134	CD55 molecule, decay accelerating factor for complement	Mus musculus	144-148
12021525-9	2002	There was a close correlation between dialysate DPD and creatinine in both dialysis modalities (HD r = 0.9, CAPD r = 0.76).	Creatinine	56-66	dihydropyrimidine dehydrogenase	Homo sapiens	48-51
11956050-9	2002	A first urine bombesin-like peptide level greater than 20,000 pg/mg creatinine (12,500 fmol/mg) between postnatal days 1-4 occurred among 54% of the infants who later developed BPD (p &lt; or = 0.001), versus 10% among non-BPD infants (specificity 90%).	Creatinine	68-78	gastrin releasing peptide	Homo sapiens	14-22
11967236-10	2002	Ad-klotho gene transfer, but not ad-lacZ gene transfer, caused an improvement of creatinine clearance, decrease in urinary protein excretion, and amelioration of histologically demonstrated tubulointerstitial damage induced by angiotensin II administration.	Creatinine	81-91	klotho	Mus musculus	3-9
11940298-9	2002	MMP-9 expression did not correlate with proteinuria, but negatively correlated with serum creatinine levels (P &lt; 0.05).	Creatinine	90-100	matrix metallopeptidase 9	Homo sapiens	0-5
12372044-12	2002	In the five patients with improved renal function, serum creatinine levels decreased significantly (2.4 +/- 0.3 mg/dL to 1.5 +/- 0.1 mg/dL, p &lt; 0.05) by a mean of 7.2 months (range 5-10 months) after conversion from CNI to rapamycin-based immunosuppression.	Creatinine	57-67	calcineurin binding protein 1	Homo sapiens	219-222
11787409-4	2001	The level of GFR should be estimated from prediction equations that take into account the serum creatinine concentration and some or all of the following variables: age, gender, race, and body size.	Creatinine	96-106	Rap guanine nucleotide exchange factor 5	Homo sapiens	13-16
11899842-4	2001	We observed that in the time of concomitant VPA and TGB therapy increased the NAG/g creatinine activity index.	Creatinine	84-94	NBAS subunit of NRZ tethering complex	Homo sapiens	78-81
11095016-8	2000	Urinary AM levels (pmol/mg urinary creatinine) were significantly higher in relapse than in remission and in controls (156+/-43 in relapse, 56+/-18 in remission, 36+/-16 in controls, P&lt;0.05).	Creatinine	35-45	adrenomedullin	Homo sapiens	8-10
10430808-0	1999	The plasma homocysteine/creatinine ratio can be used to study the implication of (C677T) MTHFR genetic variants in homocysteine homeostasis.	Creatinine	24-34	methylenetetrahydrofolate reductase	Homo sapiens	89-94
10443297-6	1999	In addition, there was a significant correlation between intensity of glomerular and interstitial tenascin staining and serum creatinine levels.	Creatinine	126-136	tenascin C	Homo sapiens	98-106
10401024-4	1999	Plasma concentrations and urinary excretion of PAMP were significantly less for the patients with CGN compared with control subjects (0.91 +/- 0.08 v 1.23 +/- 0.20 fmol/mL; P &lt; 0.05 and 25.0 +/- 3.0 v 35.0 +/- 3.6 fmol/mg of creatinine, respectively; P &lt; 0.	Creatinine	228-238	adrenomedullin	Homo sapiens	47-51
10485324-5	1999	Plasma creatinine levels significantly increased at 2, 5 and 24 h. There was a significant decrease in NEP activity as early as 2 h following reperfusion that was maintained up to 24 h (57.9 +/- 4%) with a concomitant loss of enzyme protein shown by Western analysis.	Creatinine	7-17	membrane metallo-endopeptidase	Rattus norvegicus	103-106
10485324-7	1999	Thus, decrease in NEP mRNA levels preceded the changes in protein level, enzyme activity and plasma creatinine levels.	Creatinine	100-110	membrane metallo-endopeptidase	Rattus norvegicus	18-21
10379636-13	1999	CONCLUSIONS: The true GFR of the healthy elderly remains within the normal range and is underestimated by creatinine clearance and more so by its surrogate (Cockroft-Gault clearance).	Creatinine	106-116	Rap guanine nucleotide exchange factor 5	Homo sapiens	22-25