PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 6840085-3 1983 We found a high anti-syn activation energy in the case of the pyrimidine nucleosides C and m5C, whereas for the purine nucleosides G, m6G, m7G and m8G only moderate anti-syn energetic barriers were calculated. Pyrimidine Nucleosides 62-84 synemin Homo sapiens 21-24 2327964-0 1990 Release of purine and pyrimidine nucleosides and their catabolites from the perfused rat hindlimb in response to noradrenaline, vasopressin, angiotensin II and sciatic-nerve stimulation. Pyrimidine Nucleosides 22-44 angiotensinogen Rattus norvegicus 141-155 6789872-4 1981 The other enzyme, purine nucleoside phosphorylase (PN Pase), catalyzed the synthesis of the product nucleoside by utilizing the pentose 1-phosphate ester generated from the phosphorolysis of the pyrimidine nucleoside. Pyrimidine Nucleosides 195-216 purine nucleoside phosphorylase Homo sapiens 18-49 6789872-4 1981 The other enzyme, purine nucleoside phosphorylase (PN Pase), catalyzed the synthesis of the product nucleoside by utilizing the pentose 1-phosphate ester generated from the phosphorolysis of the pyrimidine nucleoside. Pyrimidine Nucleosides 195-216 purine nucleoside phosphorylase Homo sapiens 51-58 195585-3 1977 Further, comparisons of the Km values of isolated uridine kinases with those for cellular uptake of pyrimidine nucleosides and their rate of intracellular phosphorylation suggest that nucleoside-transport systems play a rate-limiting role in nucleoside analogue activation and consequently that it is impossible to estimate the Km of uridine kinase in the intact cell. Pyrimidine Nucleosides 100-122 uridine-cytidine kinase 2 Homo sapiens 50-64 7370262-4 1980 In the absence of any such hydrogen bonding, the imidazole nucleosides expectedly exhibit nearly "free" rotation around the glycosyl bond for the commonly found C(3") endo and C(2") endo sugar ring conformations, thus increasing the probability of anti in equilibrium high-anti in equilibrium syn conformational interconversions as compared to common purine and pyrimidine nucleosides. Pyrimidine Nucleosides 362-384 synemin Homo sapiens 293-296 10793758-5 1974 It is concluded that the flexibility of the glycosidic linkage in conjunction with the pseudo-rotation of the sugar residue is responsible for these changes; the thermodynamic values which can be deduced from these decreases are compatible with an oscillatory motion around the glycosidic bond, but exclude anti-syn transformations in pyrimidine nucleosides. Pyrimidine Nucleosides 335-357 synemin Homo sapiens 312-315 4279089-0 1974 X-ray structure of 3",5"-diacetyl-2"-deoxy-2"-fluorouridine: a pyrimidine nucleoside in the syn conformation. Pyrimidine Nucleosides 63-84 synemin Homo sapiens 92-95 4835378-0 1974 Conformation of nucleosides: circular dichroism study of solvent effect on the syn-anti conformational equilibrium of pyrimidine nucleosides. Pyrimidine Nucleosides 118-140 synemin Homo sapiens 79-82 5006905-0 1972 A molecular orbital investigation of the dipole moments of the syn and anti conformers of purine and pyrimidine nucleosides. Pyrimidine Nucleosides 101-123 synemin Homo sapiens 63-66 4708382-0 1973 Determination of pyrimidine nucleoside syn, anti conformational preference in solution by proton and carbon-13 nuclear magnetic resonance. Pyrimidine Nucleosides 17-38 synemin Homo sapiens 39-42 5054836-1 1972 A pyrimidine nucleoside in the syn conformation. Pyrimidine Nucleosides 2-23 synemin Homo sapiens 31-34 33042633-2 2020 Results of clinical studies of the pyrimidine nucleoside analog decitabine to target DNMT1 in PDAC have, however, disappointed. Pyrimidine Nucleosides 35-56 DNA methyltransferase 1 Homo sapiens 85-90 5538865-0 1971 Nuclear magnetic resonance determination of syn and anti conformations in pyrimidine nucleosides. Pyrimidine Nucleosides 74-96 synemin Homo sapiens 44-47 5453353-0 1970 A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate. Pyrimidine Nucleosides 2-23 synemin Homo sapiens 31-34 13976534-1 1963 Nucleoside triphosphatase (NTPase) activity was demonstrated at the submicroscopic level in the frog retina by the Wachstein-Meisel method utilizing various purine and pyrimidine nucleosides. Pyrimidine Nucleosides 168-190 inosine triphosphatase Homo sapiens 27-33 31440421-1 2019 Background: The human concentrative nucleoside transporter 1 (hCNT1) a product of the SLC28A1 gene is one of the three concentrative nucleoside transporters, with a substrate specificity for physiological pyrimidine nucleosides. Pyrimidine Nucleosides 205-227 solute carrier family 28 member 1 Homo sapiens 22-60 32823658-0 2020 Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides. Pyrimidine Nucleosides 60-82 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 14-45 32823658-1 2020 Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. Pyrimidine Nucleosides 124-145 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 33-64 31735601-2 2020 Initial biological studies indicated that among these 4-amino acid derivative substituted pyrimidine nucleoside analogues, 4-N-(2"-amino-glutaric acid-1"-methylester)-1-(2"- deoxy-2"-beta-fluoro-4"-azido)-furanosyl-cytosine 2 exhibited the most potent anti-CVB activity (IC50 = 9.3 muM). Pyrimidine Nucleosides 90-111 latexin Homo sapiens 282-285 31440421-1 2019 Background: The human concentrative nucleoside transporter 1 (hCNT1) a product of the SLC28A1 gene is one of the three concentrative nucleoside transporters, with a substrate specificity for physiological pyrimidine nucleosides. Pyrimidine Nucleosides 205-227 solute carrier family 28 member 1 Homo sapiens 62-67 31440421-1 2019 Background: The human concentrative nucleoside transporter 1 (hCNT1) a product of the SLC28A1 gene is one of the three concentrative nucleoside transporters, with a substrate specificity for physiological pyrimidine nucleosides. Pyrimidine Nucleosides 205-227 solute carrier family 28 member 1 Homo sapiens 86-93 29602790-1 2018 BACKGROUND: Thymine kinase 2 (TK2) is a mitochondrial matrix protein encoded in nuclear DNA and phosphorylates the pyrimidine nucleosides: thymidine and deoxycytidine. Pyrimidine Nucleosides 115-137 thymidine kinase 2 Homo sapiens 12-28 31060578-1 2019 BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Pyrimidine Nucleosides 90-112 thymidine kinase 2 Homo sapiens 12-15 30796972-2 2019 Elevated thymidine phosphorylase (TP) levels, a key enzyme in the pyrimidine nucleoside salvage pathway, are associated with an aggressive disease phenotype and poor prognoses. Pyrimidine Nucleosides 66-87 thymidine phosphorylase Homo sapiens 9-32 30796972-2 2019 Elevated thymidine phosphorylase (TP) levels, a key enzyme in the pyrimidine nucleoside salvage pathway, are associated with an aggressive disease phenotype and poor prognoses. Pyrimidine Nucleosides 66-87 thymidine phosphorylase Homo sapiens 34-36 29602790-1 2018 BACKGROUND: Thymine kinase 2 (TK2) is a mitochondrial matrix protein encoded in nuclear DNA and phosphorylates the pyrimidine nucleosides: thymidine and deoxycytidine. Pyrimidine Nucleosides 115-137 thymidine kinase 2 Homo sapiens 30-33 26809303-1 2015 Gemcitabine, a pyrimidine nucleoside analogue, is gaining recognition as a potential therapeutic agent for advanced-stage and refractory cutaneous T-cell lymphoma (CTCL). Pyrimidine Nucleosides 15-36 TSPY like 2 Homo sapiens 164-168 29742194-1 2018 Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Pyrimidine Nucleosides 15-36 TSPY like 2 Homo sapiens 121-125 26080001-8 2015 The concentration dependent binding of purine and pyrimidine nucleosides to the purified recombinant protein, assessed by MST, confirmed that AtENT7-eGFP is properly folded. Pyrimidine Nucleosides 50-72 equilibrative nucleoside transporter 7 Arabidopsis thaliana 142-148 24132197-2 2013 Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Pyrimidine Nucleosides 64-86 complement C5 Homo sapiens 48-51 25215937-5 2014 TK2 also phosphorylates a number of pyrimidine nucleoside analogues used in antiviral and anticancer therapy and thus plays an important role in mitochondrial toxicities caused by nucleoside analogues. Pyrimidine Nucleosides 36-57 thymidine kinase 2 Homo sapiens 0-3 24562648-1 2014 PURPOSE: Thymidine phosphorylase (TP), a key enzyme in the pyrimidine nucleoside salvage pathway, catalyses the reversible phosphorylation of thymidine, thereby generating thymine and 2-deoxy-D-ribose-1-phosphate. Pyrimidine Nucleosides 59-80 thymidine phosphorylase Homo sapiens 9-32 24562648-1 2014 PURPOSE: Thymidine phosphorylase (TP), a key enzyme in the pyrimidine nucleoside salvage pathway, catalyses the reversible phosphorylation of thymidine, thereby generating thymine and 2-deoxy-D-ribose-1-phosphate. Pyrimidine Nucleosides 59-80 thymidine phosphorylase Homo sapiens 34-36 23452331-3 2013 In the following we have focused on dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine nucleosides biosynthetic pathway. Pyrimidine Nucleosides 107-129 dihydroorotate dehydrogenase (quinone) Homo sapiens 36-64 23932787-3 2013 To date, the myopathic form of MDS is mainly caused by mutations in the TK2 gene, which encodes thymidine kinase 2, the first and rate limiting step enzyme in the phosphorylation of pyrimidine nucleosides. Pyrimidine Nucleosides 182-204 thymidine kinase 2 Homo sapiens 72-75 23452331-3 2013 In the following we have focused on dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine nucleosides biosynthetic pathway. Pyrimidine Nucleosides 107-129 dihydroorotate dehydrogenase (quinone) Homo sapiens 66-71 23254508-4 2013 Furthermore, BALB/C nude mice bearing tumors were treated with Dm-dNK mediated with the pyrimidine nucleoside analog, brivudine [BVDU, (E)-5-(2-bromovinyl)-2"-deoxyuridine]. Pyrimidine Nucleosides 100-133 deoxyribonucleoside kinase Drosophila melanogaster 75-81 21795683-2 2011 Both transport purine and pyrimidine nucleosides and are distinguished functionally by a difference in sensitivity to inhibition by nanomolar concentrations of nitrobenzylmercaptopurine ribonucleoside (NBMPR), hENT1 being NBMPR-sensitive. Pyrimidine Nucleosides 26-48 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 210-215 22901180-5 2012 In vivo, an animal study was set out in which BALB/C nude mice bearing tumors were treated with lentivirus mediated expression of Dm-dNKmut with the pyrimidine nucleoside analog brivudine (BVDU, (E)-5-(2-bromovinyl)-(2-deoxyuridine). Pyrimidine Nucleosides 149-170 deoxyribonucleoside kinase Drosophila melanogaster 130-139 21565176-8 2011 Using these techniques we identified two splicing factor proteins, serine/arginine-rich splicing factor 3 (SRSF3) and splicing factor proline/glutamine-rich (SFPQ), that induced resistance to dFdC as well as other pyrimidine nucleoside analogs when their expression was decreased in HeLa cells. Pyrimidine Nucleosides 214-235 serine and arginine rich splicing factor 3 Homo sapiens 67-105 21565176-8 2011 Using these techniques we identified two splicing factor proteins, serine/arginine-rich splicing factor 3 (SRSF3) and splicing factor proline/glutamine-rich (SFPQ), that induced resistance to dFdC as well as other pyrimidine nucleoside analogs when their expression was decreased in HeLa cells. Pyrimidine Nucleosides 214-235 serine and arginine rich splicing factor 3 Homo sapiens 107-112 21565176-8 2011 Using these techniques we identified two splicing factor proteins, serine/arginine-rich splicing factor 3 (SRSF3) and splicing factor proline/glutamine-rich (SFPQ), that induced resistance to dFdC as well as other pyrimidine nucleoside analogs when their expression was decreased in HeLa cells. Pyrimidine Nucleosides 214-235 splicing factor proline and glutamine rich Homo sapiens 158-162 21761307-2 2011 Thymidine phosphorylase (TP) is involved in the control of the pyrimidine nucleoside pool of the cell. Pyrimidine Nucleosides 63-84 thymidine phosphorylase Homo sapiens 0-23 21444706-2 2011 TK2 phosphorylates thymidine (dThd), deoxycytidine (dCyd), and many other antiviral pyrimidine nucleoside analogs. Pyrimidine Nucleosides 84-105 thymidine kinase 2 Homo sapiens 0-3 21674733-3 2011 We further determined the enzymatic activity and the sensitivity of the nontransduced and Dm-dNK-transduced 231/dNK and MCF7/dNK cells to the pyrimidine nucleoside analogs araC and araT. Pyrimidine Nucleosides 142-163 deoxyribonucleoside kinase Drosophila melanogaster 90-96 21674733-3 2011 We further determined the enzymatic activity and the sensitivity of the nontransduced and Dm-dNK-transduced 231/dNK and MCF7/dNK cells to the pyrimidine nucleoside analogs araC and araT. Pyrimidine Nucleosides 142-163 deoxyribonucleoside kinase Drosophila melanogaster 93-96 21674733-3 2011 We further determined the enzymatic activity and the sensitivity of the nontransduced and Dm-dNK-transduced 231/dNK and MCF7/dNK cells to the pyrimidine nucleoside analogs araC and araT. Pyrimidine Nucleosides 142-163 deoxyribonucleoside kinase Drosophila melanogaster 112-115 21761307-2 2011 Thymidine phosphorylase (TP) is involved in the control of the pyrimidine nucleoside pool of the cell. Pyrimidine Nucleosides 63-84 thymidine phosphorylase Homo sapiens 25-27 20544523-1 2010 Thymidine kinase 2 (TK2) is one of four deoxynucleoside kinases (dNKs) in humans and plays a crucial role in the initial phosphorylation of pyrimidine nucleosides in the salvage pathway in mitochondria. Pyrimidine Nucleosides 140-162 thymidine kinase 2 Homo sapiens 0-18 20544523-1 2010 Thymidine kinase 2 (TK2) is one of four deoxynucleoside kinases (dNKs) in humans and plays a crucial role in the initial phosphorylation of pyrimidine nucleosides in the salvage pathway in mitochondria. Pyrimidine Nucleosides 140-162 thymidine kinase 2 Homo sapiens 20-23 20391188-0 2010 Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts. Pyrimidine Nucleosides 34-55 thymidine kinase 2 Homo sapiens 67-85 20060452-1 2010 Concentrative nucleoside transporter 1 (CNT1, SLC28A1) is a key molecule for determining the pharmacokinetic/pharmacodynamic profile of a candidate compound derived from a pyrimidine nucleoside, but there is no available information on the differences in the functional profile of this ortholog between man and mouse. Pyrimidine Nucleosides 172-193 solute carrier family 28 member 1 Homo sapiens 0-38 20060452-1 2010 Concentrative nucleoside transporter 1 (CNT1, SLC28A1) is a key molecule for determining the pharmacokinetic/pharmacodynamic profile of a candidate compound derived from a pyrimidine nucleoside, but there is no available information on the differences in the functional profile of this ortholog between man and mouse. Pyrimidine Nucleosides 172-193 solute carrier family 28 member 1 Homo sapiens 40-44 20060452-1 2010 Concentrative nucleoside transporter 1 (CNT1, SLC28A1) is a key molecule for determining the pharmacokinetic/pharmacodynamic profile of a candidate compound derived from a pyrimidine nucleoside, but there is no available information on the differences in the functional profile of this ortholog between man and mouse. Pyrimidine Nucleosides 172-193 solute carrier family 28 member 1 Homo sapiens 46-53 20060452-5 2010 These results demonstrate that the transport characteristics of mCNT1 are almost the same as those of hCNT1, suggesting that mice may be a good animal model in evaluation of pyrimidine nucleoside analogues as to their applicability in human therapy. Pyrimidine Nucleosides 174-195 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Mus musculus 64-69 20522971-1 2010 2"-Deoxycytidine (dCyd), a pyrimidine nucleoside found at high concentrations in the plasma of cancer patients with a poor prognosis after chemotherapy, is considered to be a biomarker for breast cancer. Pyrimidine Nucleosides 27-48 Cyd Drosophila melanogaster 18-22 20391188-4 2010 The TK2 deficient cells retained their sensitivity against all pyrimidine nucleoside analogs tested. Pyrimidine Nucleosides 63-84 thymidine kinase 2 Homo sapiens 4-7 19772189-6 2009 Thymidine Phosphorylase is involved in the control and maintenance of the pyrimidine nucleoside pool of the cell. Pyrimidine Nucleosides 74-95 thymidine phosphorylase Homo sapiens 0-23 19228884-2 2009 CNT1 mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogs used in anticancer and antiviral therapy. Pyrimidine Nucleosides 48-70 solute carrier family 28 member 1 Homo sapiens 0-4 18668437-6 2008 The best-characterized members of the family, hENT1 and hENT2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases. Pyrimidine Nucleosides 123-145 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 46-51 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Pyrimidine Nucleosides 256-278 solute carrier family 28 member 1 Homo sapiens 130-134 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Pyrimidine Nucleosides 256-278 solute carrier family 28 member 1 Homo sapiens 136-141 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Pyrimidine Nucleosides 256-278 solute carrier family 28 member 2 Homo sapiens 147-152 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Pyrimidine Nucleosides 256-278 solute carrier family 28 member 3 Homo sapiens 223-228 18668437-6 2008 The best-characterized members of the family, hENT1 and hENT2, possess similar broad permeant selectivities for purine and pyrimidine nucleosides, but hENT2 also efficiently transports nucleobases. Pyrimidine Nucleosides 123-145 solute carrier family 29 member 2 Homo sapiens 56-61 18199742-2 2008 Belonging to a CNT subfamily phylogenetically distinct from hCNT1/2, hCNT3 mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drugs, whereas hCNT1 and hCNT2 are pyrimidine and purine nucleoside-selective, respectively. Pyrimidine Nucleosides 125-147 solute carrier family 28 member 3 Homo sapiens 69-74 17253988-0 2007 The fluorouridine insensitive 1 (fur1) mutant is defective in equilibrative nucleoside transporter 3 (ENT3), and thus represents an important pyrimidine nucleoside uptake system in Arabidopsis thaliana. Pyrimidine Nucleosides 142-163 Major facilitator superfamily protein Arabidopsis thaliana 62-100 17412768-2 2007 Murine PCT cells grown on a transwell dish showed endogenous CNT3 activity at their apical membrane that was responsible for the sodium-dependent transepithelial flux of both purine and pyrimidine nucleosides. Pyrimidine Nucleosides 186-208 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 Mus musculus 61-65 17595142-4 2007 These reactions at the C-4 position are nontrivial in comparison with similar reactions at the C-5 position of pyrimidine nucleosides, with hydrolysis of the arylsulfonate precursor being a competing reaction in some cases. Pyrimidine Nucleosides 111-133 complement C4A (Rodgers blood group) Homo sapiens 23-26 17595142-4 2007 These reactions at the C-4 position are nontrivial in comparison with similar reactions at the C-5 position of pyrimidine nucleosides, with hydrolysis of the arylsulfonate precursor being a competing reaction in some cases. Pyrimidine Nucleosides 111-133 complement C5 Homo sapiens 95-98 17595142-9 2007 The study represents the first successful synthesis of C-4 aryl pyrimidinone nucleoside analogues by cross-coupling of arylboronic acids with an arylsulfonate derived from a pyrimidine nucleoside, as well as antiviral testing of this new class of compounds. Pyrimidine Nucleosides 174-195 complement C4A (Rodgers blood group) Homo sapiens 55-58 17253988-0 2007 The fluorouridine insensitive 1 (fur1) mutant is defective in equilibrative nucleoside transporter 3 (ENT3), and thus represents an important pyrimidine nucleoside uptake system in Arabidopsis thaliana. Pyrimidine Nucleosides 142-163 Major facilitator superfamily protein Arabidopsis thaliana 102-106 17126452-3 2007 In this paper, we report that human astrocytoma cells (ADF) undergoing ischemic conditions may use both purine and pyrimidine nucleosides as energy source to slow down cellular damage. Pyrimidine Nucleosides 115-137 destrin, actin depolymerizing factor Homo sapiens 55-58 16271041-1 2006 hCNT3 (human concentrative nucleoside transporter 3) is a nucleoside-sodium symporter that transports a broad range of naturally occurring purine and pyrimidine nucleosides as well as anticancer nucleoside drugs. Pyrimidine Nucleosides 150-172 solute carrier family 28 member 3 Homo sapiens 0-5 16759112-3 2006 We have synthesized a series of pyrimidine nucleosides possessing a variety of substituents at the C-5 position, and a 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] flexible acyclic glycosyl moiety at the N-1 position, that have the ability to mimic the natural 2"-deoxyribosyl moiety. Pyrimidine Nucleosides 32-54 complement C5 Homo sapiens 99-102 16421443-6 2006 The crystal structure of dCK has been solved previously in complex with pyrimidine nucleosides and ADP [Sabini et al. Pyrimidine Nucleosides 72-94 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 25-28 16305527-8 2005 In this scenario, TK-2 inhibitors could be a useful tool to further clarify both the physiological role of TK-2 in the maintenance of mitochondrial dNTP pools, and the possible contribution of TK-2 to the mitochondrial toxicity of pyrimidine nucleoside analogues. Pyrimidine Nucleosides 231-252 thymidine kinase 2 Homo sapiens 18-22 15870078-2 2005 hCNT3, a Na+/nucleoside symporter, transports a broad range of physiological purine and pyrimidine nucleosides as well as anticancer and antiviral nucleoside drugs, and belongs to a different CNT subfamily than hCNT1/2. Pyrimidine Nucleosides 88-110 solute carrier family 28 member 3 Homo sapiens 0-5 15876539-2 2005 Recently, crystal structures of dCK (dCKc) with various pyrimidine nucleosides as substrates have been reported. Pyrimidine Nucleosides 56-78 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 32-35 15861042-1 2005 INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene. Pyrimidine Nucleosides 116-138 solute carrier family 28 member 3 Homo sapiens 60-65 15861042-1 2005 INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene. Pyrimidine Nucleosides 116-138 solute carrier family 28 member 3 Homo sapiens 67-74 15861042-1 2005 INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene. Pyrimidine Nucleosides 116-138 solute carrier family 28 member 3 Homo sapiens 303-308 15651758-1 2004 Human concentrative nucleoside transporter-1 (hCNT1) (SLC28A1) is a widely expressed, high-affinity, pyrimidine-preferring, nucleoside transporter implicated in the uptake of naturally occurring pyrimidine nucleosides as well as a variety of derivatives used in anticancer treatment. Pyrimidine Nucleosides 195-217 solute carrier family 28 member 1 Homo sapiens 6-44 15651758-1 2004 Human concentrative nucleoside transporter-1 (hCNT1) (SLC28A1) is a widely expressed, high-affinity, pyrimidine-preferring, nucleoside transporter implicated in the uptake of naturally occurring pyrimidine nucleosides as well as a variety of derivatives used in anticancer treatment. Pyrimidine Nucleosides 195-217 solute carrier family 28 member 1 Homo sapiens 46-51 15651758-1 2004 Human concentrative nucleoside transporter-1 (hCNT1) (SLC28A1) is a widely expressed, high-affinity, pyrimidine-preferring, nucleoside transporter implicated in the uptake of naturally occurring pyrimidine nucleosides as well as a variety of derivatives used in anticancer treatment. Pyrimidine Nucleosides 195-217 solute carrier family 28 member 1 Homo sapiens 54-61 15651758-6 2004 Thus, hCNT1 cannot be considered a broad-selectivity pyrimidine nucleoside carrier; in fact, very slight changes in substrate structure provoke a dramatic shift in selectivity. Pyrimidine Nucleosides 53-74 solute carrier family 28 member 1 Homo sapiens 6-11 15544474-13 2004 Structural requirements at the C-2 carbon of the 5-substituent of pyrimidine nucleosides have been well established for anti-herpes activity. Pyrimidine Nucleosides 66-88 complement C2 Homo sapiens 31-34 15464233-1 2004 BACKGROUND/AIMS: Concentrative nucleoside transporter 1 (CNT1), a high affinity transporter for pyrimidine nucleosides, is responsible for their Na+-dependent concentrative uptake into hepatocytes. Pyrimidine Nucleosides 96-118 solute carrier family 28 member 1 Rattus norvegicus 17-55 15544474-14 2004 However, there is little qualitative or mechanistic knowledge of the derivatives with substitution at the C-1 carbon of the 5-substituent of pyrimidine nucleosides. Pyrimidine Nucleosides 141-163 heterogeneous nuclear ribonucleoprotein C Homo sapiens 106-109 15544474-15 2004 During the last few years of our research, we have investigated a variety of C-1 functionalized substituents at the 5-position of the pyrimidine nucleosides to determine their usefulness as antiviral (herpes) agents. Pyrimidine Nucleosides 134-156 heterogeneous nuclear ribonucleoprotein C Homo sapiens 77-80 15544474-16 2004 In the 5-(1-substituted) group of pyrimidine nucleosides, we demonstrated that novel substituents present at the C-1 carbon of the 5-side chain of the pyrimidine nucleosides are important determinants of potent and broad spectrum antiviral (herpes) activity including EBV and HCMV. Pyrimidine Nucleosides 34-56 heterogeneous nuclear ribonucleoprotein C Homo sapiens 113-116 15544474-16 2004 In the 5-(1-substituted) group of pyrimidine nucleosides, we demonstrated that novel substituents present at the C-1 carbon of the 5-side chain of the pyrimidine nucleosides are important determinants of potent and broad spectrum antiviral (herpes) activity including EBV and HCMV. Pyrimidine Nucleosides 151-173 heterogeneous nuclear ribonucleoprotein C Homo sapiens 113-116 15464233-1 2004 BACKGROUND/AIMS: Concentrative nucleoside transporter 1 (CNT1), a high affinity transporter for pyrimidine nucleosides, is responsible for their Na+-dependent concentrative uptake into hepatocytes. Pyrimidine Nucleosides 96-118 solute carrier family 28 member 1 Rattus norvegicus 57-61 12838422-4 2004 The best-characterised members of the family, hENT1 and hENT2, possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases. Pyrimidine Nucleosides 124-146 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 46-51 15294454-0 2004 Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06. Pyrimidine Nucleosides 25-46 ATP binding cassette subfamily B member 1 Homo sapiens 83-87 14978229-1 2004 The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs. Pyrimidine Nucleosides 110-132 solute carrier family 28 member 1 Homo sapiens 42-46 14978229-1 2004 The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs. Pyrimidine Nucleosides 110-132 solute carrier family 28 member 1 Homo sapiens 48-55 12838422-4 2004 The best-characterised members of the family, hENT1 and hENT2, possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases. Pyrimidine Nucleosides 124-146 solute carrier family 29 member 2 Homo sapiens 56-61 12856181-2 2004 These subtypes differ in their substrate specificities: CNT1 is pyrimidine-nucleoside preferring, CNT2 is purine-nucleoside preferring, and CNT3 transports both pyrimidine and purine nucleosides. Pyrimidine Nucleosides 64-85 solute carrier family 28 member 1 Homo sapiens 56-60 12893280-8 2003 Among several pyrimidine nucleosides, hCNT2 favorably interacted with the uridine analogue floxuridine. Pyrimidine Nucleosides 14-36 solute carrier family 28 member 2 Homo sapiens 38-43 14504928-10 2003 Physiologically, hCNT3 is a glycoprotein, which transports purine and pyrimidine nucleosides in a Na-dependent manner with high affinities. Pyrimidine Nucleosides 70-92 solute carrier family 28 member 3 Homo sapiens 17-22 12810710-13 2003 In competition experiments, the transport of [3H]adenosine by AtENT3 was most significantly inhibited by a number of different purine and pyrimidine nucleosides and 2"-deoxynucleosides, although certain nucleobases and nucleotides were also found to have some inhibitory effect. Pyrimidine Nucleosides 138-160 Major facilitator superfamily protein Arabidopsis thaliana 62-68 14565481-1 2003 The introduction of sulfonamido group on the C-2 position of pyrimidine nucleosides was achieved by ring opening of 2,2"- and 2,3"-anhydronucleosides. Pyrimidine Nucleosides 61-83 complement C2 Homo sapiens 45-48 12849978-4 2003 The novel enzyme, named uridine phosphorylase-2 (UPase-2), showed broad substrate specificity and accepted uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(")-deoxyuridine. Pyrimidine Nucleosides 163-184 uridine phosphorylase 2 Homo sapiens 24-47 12849978-4 2003 The novel enzyme, named uridine phosphorylase-2 (UPase-2), showed broad substrate specificity and accepted uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(")-deoxyuridine. Pyrimidine Nucleosides 163-184 uridine phosphorylase 2 Homo sapiens 49-56 12823558-2 2003 Dm-dNK phosphorylates both purine and pyrimidine deoxyribonucleosides and nucleoside analogues although it has a preference for pyrimidine nucleosides. Pyrimidine Nucleosides 128-150 deoxyribonucleoside kinase Drosophila melanogaster 0-6 14510358-0 2003 Study on the reaction mechanism of C-6 lithiation of pyrimidine nucleosides by using lithium hexamethyldisilazide as a base. Pyrimidine Nucleosides 53-75 complement C6 Homo sapiens 35-38 12055084-1 2002 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively. Pyrimidine Nucleosides 100-121 solute carrier family 28 member 1 Homo sapiens 72-77 12207516-5 2002 A breakdown of the key Fermi contact part of (3)J(C6/8-H1") into MO contributions rationalizes this trend in terms of an unusual coupling mechanism in the syn orientation that is very effective for pyrimidine nucleosides and considerably weaker for purine nucleosides. Pyrimidine Nucleosides 198-220 synemin Homo sapiens 155-158 12055084-1 2002 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively. Pyrimidine Nucleosides 100-121 solute carrier family 28 member 2 Homo sapiens 79-84 12055084-1 2002 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively. Pyrimidine Nucleosides 100-121 solute carrier family 28 member 3 Homo sapiens 90-95 9705281-3 1998 When expressed in Xenopus oocytes, recombinant hENT1 and rENT1 transport both purine and pyrimidine nucleosides, including adenosine, and are inhibited by nanomolar concentrations of NBMPR. Pyrimidine Nucleosides 89-111 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 47-52 11956089-5 2002 The experimental data indicate that the disruption of UPase activity in murine ES cells leads to a 10-fold increase in 5-FU IC(50) and a 2-3-fold reduction in its incorporation into nucleic acids, whereas no differences in toxicity is seen with other pyrimidine nucleoside analogues such as 5-fluorouridine, 2"-deoxy-5-fluorouridine, and 1-beta-D-arabinofuranosylcytosine compared with WT (wild-type) ES cells. Pyrimidine Nucleosides 251-272 uridine phosphorylase 1 Mus musculus 54-59 11927571-3 2002 Insects appear to have only one multisubstrate deoxyribonucleoside kinase (dNK, EC 2.7.1.145), which prefers pyrimidine nucleosides, but can also phosphorylate purine substrates. Pyrimidine Nucleosides 109-131 deoxyribonucleoside kinase Drosophila melanogaster 47-73 11927571-3 2002 Insects appear to have only one multisubstrate deoxyribonucleoside kinase (dNK, EC 2.7.1.145), which prefers pyrimidine nucleosides, but can also phosphorylate purine substrates. Pyrimidine Nucleosides 109-131 deoxyribonucleoside kinase Drosophila melanogaster 75-78 11807789-1 2002 Uridine phosphorylase (UPase) and an angiogenic enzyme, thymidine phosphorylase (dThdPase) are involved in degradation of the pyrimidine nucleosides through phosphorolysis. Pyrimidine Nucleosides 126-148 uridine phosphorylase 1 Homo sapiens 23-28 11795870-6 2002 PN-I possess phosphotransferase activity able to exchange phosphate between pyrimidine nucleoside monophosphates and pyrimidine nucleosides, including AZT and Ara-Cyd. Pyrimidine Nucleosides 117-139 5'-nucleotidase, cytosolic IIIA Homo sapiens 0-4 12440703-0 2002 Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae. Pyrimidine Nucleosides 62-83 solute carrier family 29 member 2 Homo sapiens 117-155 12440703-0 2002 Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae. Pyrimidine Nucleosides 62-83 solute carrier family 29 member 2 Homo sapiens 157-162 12440703-1 2002 The human equilibrative nucleoside transporters I and 2 (hENT1, hENT2) share 50% amino acid identity and exhibit broad selectivities, accepting purine and pyrimidine nucleosides as permeants. Pyrimidine Nucleosides 155-177 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 57-62 12440703-1 2002 The human equilibrative nucleoside transporters I and 2 (hENT1, hENT2) share 50% amino acid identity and exhibit broad selectivities, accepting purine and pyrimidine nucleosides as permeants. Pyrimidine Nucleosides 155-177 solute carrier family 29 member 2 Homo sapiens 64-69 11641443-2 2001 Stable transfer of hCNT2 cDNA into CEM-ARAC enabled Na(+)-dependent transport of purine and pyrimidine nucleoside analogs and provided a unique in vitro model for studying hCNT2. Pyrimidine Nucleosides 92-113 solute carrier family 28 member 2 Homo sapiens 19-24 11668512-3 2001 Thymidine phosphorylase (TP) anabolises formation of pyrimidine nucleosides available for DNA synthesis, whereas dihydropyrimidine dehydrogenase (DPD) catabolises the degradation of pyrimidine bases, thereby reducing levels of uracil and thymine available for DNA synthesis. Pyrimidine Nucleosides 53-75 dihydropyrimidine dehydrogenase Homo sapiens 146-149 11032837-0 2001 Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Pyrimidine Nucleosides 174-196 solute carrier family 28 member 3 Homo sapiens 124-129 11032837-0 2001 Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Pyrimidine Nucleosides 174-196 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 Mus musculus 134-139 11032837-0 2001 Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Pyrimidine Nucleosides 174-196 calcium and integrin binding 1 (calmyrin) Mus musculus 205-208 11032837-1 2001 The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Pyrimidine Nucleosides 108-130 solute carrier family 28 member 1 Homo sapiens 74-79 11032837-1 2001 The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Pyrimidine Nucleosides 108-130 solute carrier family 28 member 2 Homo sapiens 84-89 11179696-7 2001 CEM/C19 cells stably expressing mENT1.1 and mENT1.2 show similar dose response curves for NBMPR and dipyridamole inhibition of [(3)H]adenosine uptake as well as exhibiting comparable selectivity for both purine and pyrimidine nucleosides but not the corresponding nucleobases. Pyrimidine Nucleosides 215-237 solute carrier family 29 (nucleoside transporters), member 1 Mus musculus 32-37 11179696-7 2001 CEM/C19 cells stably expressing mENT1.1 and mENT1.2 show similar dose response curves for NBMPR and dipyridamole inhibition of [(3)H]adenosine uptake as well as exhibiting comparable selectivity for both purine and pyrimidine nucleosides but not the corresponding nucleobases. Pyrimidine Nucleosides 215-237 solute carrier family 29 (nucleoside transporters), member 1 Mus musculus 44-49 11396613-0 2001 Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Pyrimidine Nucleosides 230-252 solute carrier family 28 member 3 Homo sapiens 180-185 11396613-0 2001 Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Pyrimidine Nucleosides 230-252 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 Mus musculus 190-195 11396613-1 2001 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Pyrimidine Nucleosides 149-171 solute carrier family 28 member 1 Homo sapiens 72-77 11396613-1 2001 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Pyrimidine Nucleosides 149-171 solute carrier family 28 member 2 Homo sapiens 82-87 11396614-3 2001 The pyrimidine-nucleoside selective concentrative transporters from human (hCNT1) and rat (rCNT1) complemented the imposed thymidylate depletion in S. cerevisiae, as did N-terminally truncated versions of hCNT1 and rCNT1 lacking up to 31 amino acids. Pyrimidine Nucleosides 4-25 solute carrier family 28 member 1 Homo sapiens 75-80 11396614-3 2001 The pyrimidine-nucleoside selective concentrative transporters from human (hCNT1) and rat (rCNT1) complemented the imposed thymidylate depletion in S. cerevisiae, as did N-terminally truncated versions of hCNT1 and rCNT1 lacking up to 31 amino acids. Pyrimidine Nucleosides 4-25 solute carrier family 28 member 1 Rattus norvegicus 91-96 11396614-3 2001 The pyrimidine-nucleoside selective concentrative transporters from human (hCNT1) and rat (rCNT1) complemented the imposed thymidylate depletion in S. cerevisiae, as did N-terminally truncated versions of hCNT1 and rCNT1 lacking up to 31 amino acids. Pyrimidine Nucleosides 4-25 solute carrier family 28 member 1 Homo sapiens 205-210 11396614-3 2001 The pyrimidine-nucleoside selective concentrative transporters from human (hCNT1) and rat (rCNT1) complemented the imposed thymidylate depletion in S. cerevisiae, as did N-terminally truncated versions of hCNT1 and rCNT1 lacking up to 31 amino acids. Pyrimidine Nucleosides 4-25 solute carrier family 28 member 1 Rattus norvegicus 215-220 11023833-9 2000 A number of cytostatic pyrimidine nucleoside analogues were also tested and shown to be good substrates for the various forms of TK2. Pyrimidine Nucleosides 23-44 thymidine kinase 2, mitochondrial Mus musculus 129-132 10799656-1 2000 Mitochondrial thymidine kinase (TK2) phosphorylates pyrimidine nucleosides to monophosphates and is expressed constitutively through the cell cycle in all cells. Pyrimidine Nucleosides 52-74 thymidine kinase 2 Homo sapiens 32-35 10799656-9 2000 These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides. Pyrimidine Nucleosides 63-85 thymidine kinase 2 Homo sapiens 106-109 10455109-3 1999 When produced in Xenopus oocytes, recombinant hCNT1 is selective for pyrimidine nucleosides (system cit), whereas hCNT2 is selective for purine nucleosides (system cif). Pyrimidine Nucleosides 69-91 solute carrier family 28 member 1 Homo sapiens 46-51 10087507-1 1998 Two Na(+)-dependent nucleoside transporters implicated in adenosine and uridine transport in mammalian cells are distinguished functionally on the basis of substrate specificity: CNT1 is selective for pyrimidine nucleosides but also transports adenosine; CNT2 (also termed SPNT) is selective for purine nucleosides but also transports uridine. Pyrimidine Nucleosides 201-223 solute carrier family 28 member 1 Homo sapiens 179-183 9705281-3 1998 When expressed in Xenopus oocytes, recombinant hENT1 and rENT1 transport both purine and pyrimidine nucleosides, including adenosine, and are inhibited by nanomolar concentrations of NBMPR. Pyrimidine Nucleosides 89-111 solute carrier family 29 member 1 Rattus norvegicus 57-62 9480921-12 1998 This second isoform turned out to be identical to the "epithelial-specific isoform" called cNT1, which shows in fact high specificity for pyrimidine nucleosides. Pyrimidine Nucleosides 138-160 solute carrier family 28 member 1 Rattus norvegicus 91-95 10353719-5 1998 We have used L1210/DNC3 as the recipient in gene transfer studies to develop a stable cell line (L1210/DU5) that produces the recombinant concentrative nucleoside transporter with selectivity for pyrimidine nucleosides (CNT1) that was initially identified in rat intestine (Q.Q. Pyrimidine Nucleosides 196-218 solute carrier family 28 member 1 Rattus norvegicus 220-224 9124315-8 1997 hCNT1 was 83% identical to rCNT1 in amino acid sequence and exhibited the transport characteristics of an Na+-dependent nucleoside transporter with selectivity for pyrimidine nucleosides and adenosine when expressed in Xenopus oocytes. Pyrimidine Nucleosides 164-186 solute carrier family 28 member 1 Homo sapiens 0-5 9461577-1 1998 In mammalian cells, there are three pyrimidine nucleoside salvage enzymes with the capacity to phosphorylate all four deoxynucleosides, the two thymidine kinase isoenzymes, TK1 and TK2, and the deoxycytidine kinase, dCK. Pyrimidine Nucleosides 36-57 thymidine kinase 1 Homo sapiens 173-176 9461577-1 1998 In mammalian cells, there are three pyrimidine nucleoside salvage enzymes with the capacity to phosphorylate all four deoxynucleosides, the two thymidine kinase isoenzymes, TK1 and TK2, and the deoxycytidine kinase, dCK. Pyrimidine Nucleosides 36-57 thymidine kinase 2 Homo sapiens 181-184 9461577-1 1998 In mammalian cells, there are three pyrimidine nucleoside salvage enzymes with the capacity to phosphorylate all four deoxynucleosides, the two thymidine kinase isoenzymes, TK1 and TK2, and the deoxycytidine kinase, dCK. Pyrimidine Nucleosides 36-57 deoxycytidine kinase Homo sapiens 194-214 9461577-1 1998 In mammalian cells, there are three pyrimidine nucleoside salvage enzymes with the capacity to phosphorylate all four deoxynucleosides, the two thymidine kinase isoenzymes, TK1 and TK2, and the deoxycytidine kinase, dCK. Pyrimidine Nucleosides 36-57 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 216-219 8700147-5 1996 Recombinant rCNT1 transports physiological pyrimidine nucleosides and adenosine. Pyrimidine Nucleosides 43-65 solute carrier family 28 member 1 Rattus norvegicus 12-17 8812871-12 1996 Since CDA causes the deamination of several antitumoral cytidine-analog drugs, the recombinant enzyme was characterized kinetically and several pyrimidine nucleoside analogs were tested as potential substrates and inhibitors. Pyrimidine Nucleosides 144-165 cytidine deaminase Homo sapiens 6-9 8700147-6 1996 In the current investigation, functional expression in Xenopus oocytes was used to determine whether recombinant rCNT1 also transports antiviral pyrimidine nucleoside analogs. Pyrimidine Nucleosides 145-166 solute carrier family 28 member 1 Rattus norvegicus 113-118 8027026-8 1994 cNT1 therefore belongs to a potential new gene family and may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). Pyrimidine Nucleosides 125-146 solute carrier family 28 member 1 Homo sapiens 0-4 8713072-0 1996 Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells. Pyrimidine Nucleosides 106-128 solute carrier family 28 member 1 Rattus norvegicus 130-134 8713072-4 1996 Recombinant cNT1rat was sodium-dependent and selective for pyrimidine nucleosides, with approximately Km values of 21 microM, 12.5 microM and 15 microM for uridine, thymidine and adenosine, respectively. Pyrimidine Nucleosides 59-81 solute carrier family 28 member 1 Rattus norvegicus 12-16 8789189-1 1995 A representative range of pyrimidine nucleoside analogues that are known to inhibit herpes simplex virus (HSV) replication have been used to construct receptor binding site models for the varicella-zoster virus (VZV) thymidine kinase (TK) and human TK1. Pyrimidine Nucleosides 26-47 thymidine kinase 1 Homo sapiens 249-252 8027026-5 1994 Functionally, cNT1 exhibited the transport characteristics of the nucleoside transport system cit (selective for pyrimidine nucleosides and adenosine) and accepted both 3"-azido-3"-deoxythymidine (AZT) and 2",3"-dideoxycytidine (ddC) as permeants (Km = 0.49 and 0.51 mM, respectively). Pyrimidine Nucleosides 113-135 solute carrier family 28 member 1 Homo sapiens 14-18 8417151-3 1993 The purified substance from the NF1 extracts by HPLC on ODS columns was identical to a pyrimidine nucleoside, uridine, the chemical structure of which was identified by gas chromatography-mass spectrometry. Pyrimidine Nucleosides 87-108 neurofibromin 1 Homo sapiens 32-35