PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 17034127-1 2006 From a set of weakly potent lead compounds, using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as inhibitors of the MDM2-p53 interaction. 2-alkyl-3-aryl-3-alkoxyisoindolinones 111-148 MDM2 proto-oncogene Homo sapiens 190-194 17034127-1 2006 From a set of weakly potent lead compounds, using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as inhibitors of the MDM2-p53 interaction. 2-alkyl-3-aryl-3-alkoxyisoindolinones 111-148 tumor protein p53 Homo sapiens 195-198