PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11354001-3	2001	The mutant binds cofactor (both oxidized and reduced) more tightly than the wild-type enzyme but shows a complete lack of binding of the aldehyde reductase inhibitor barbitone, as determined by fluorescence titrations.	Barbital	166-175	aldo-keto reductase family 1 member B	Sus scrofa	137-155
22467201-2	2012	The results revealed that MAO-B was activated by BA, DEBA, TBA, TU, and ATU, and the activation was structural, concentration, and time dependent.	Barbital	53-57	monoamine oxidase B	Rattus norvegicus	26-31
8973362-15	1996	Barbital induces all these genes in all three strains and increases the levels of the two Cyp6a8 transcripts and the 1.8-kb RNA produced by the Cyp6a9 and/or Cyp6a9-related genes.	Barbital	0-8	Cytochrome P450-6a8	Drosophila melanogaster	90-96
9852951-0	1998	Constitutive and barbital-induced expression of the Cyp6a2 allele of a high producer strain of CYP6A2 in the genetic background of a low producer strain.	Barbital	17-25	Cytochrome P450-6a2	Drosophila melanogaster	52-58
9852951-0	1998	Constitutive and barbital-induced expression of the Cyp6a2 allele of a high producer strain of CYP6A2 in the genetic background of a low producer strain.	Barbital	17-25	Cytochrome P450-6a2	Drosophila melanogaster	95-101
8973362-15	1996	Barbital induces all these genes in all three strains and increases the levels of the two Cyp6a8 transcripts and the 1.8-kb RNA produced by the Cyp6a9 and/or Cyp6a9-related genes.	Barbital	0-8	Cytochrome P450-6a9	Drosophila melanogaster	144-150
8973362-15	1996	Barbital induces all these genes in all three strains and increases the levels of the two Cyp6a8 transcripts and the 1.8-kb RNA produced by the Cyp6a9 and/or Cyp6a9-related genes.	Barbital	0-8	Cytochrome P450-6a9	Drosophila melanogaster	158-164
3978310-3	1985	HACU was inhibited by drugs which have in common the ability to facilitate gamma-aminobutyric acid (GABA) transmission, pentobarbitone, phenobarbitone, barbitone, diazepam, chloridiazepoxide, and valproic acid.	Barbital	125-134	high affinity choline uptake	Mus musculus	0-4
34299653-3	2021	The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method.	Barbital	134-142	SAFB like transcription modulator	Homo sapiens	114-123
34299653-3	2021	The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method.	Barbital	144-147	SAFB like transcription modulator	Homo sapiens	114-123
34299653-3	2021	The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method.	Barbital	144-147	SAFB like transcription modulator	Homo sapiens	125-128
2517349-3	1989	The percent of free T4 (% free T4) was also measured by equilibrium dialysis against veronal buffer in which T4-binding by TBPA was completely abolished.	Barbital	85-92	transthyretin	Homo sapiens	123-127
3752940-2	1986	Using DCC procedure as the basis, the extraction and incubation of ER and PgR is more efficiently achieved by phosphate buffer as compared with water, tris and veronal buffers.	Barbital	160-167	progesterone receptor	Oryctolagus cuniculus	74-77
4026191-2	1985	In Tris-HCl buffer pH 7.5 or barbitone buffer pH 8.1 containing 5 g/L bovine serum albumin, the isoenzymes appeared to be stable for up to 3 weeks at 4 degrees C but suffered a partial subunit dissociation and random reassociation after freeze-thawing; this dissociation was more pronounced as a result of freezing at -20 degrees C rather than at -70 degrees C. In contrast, creatine kinase isoenzymes stored in serum were stable at both 4 degrees C and following freeze-thawing.	Barbital	29-38	albumin	Homo sapiens	77-90
1417986-4	1992	PB and two structural analogues (ethylphenylhydantoin and barbital) induced a variety of drug-metabolizing enzymes (CYP2B, CYP3A, CYP2A, epoxide hydrolase) in a series of inbred strains of rats.	Barbital	58-66	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	123-128
1526138-2	1992	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-amino-levulinate synthetase (ALA-S), cytoplasmic and mitochondrial rhodanese were determined in tumor (T) and liver of both normal mice (NM) and T-bearing mice (TBM).	Barbital	51-58	aminolevulinic acid synthase 1	Mus musculus	77-110
1526138-2	1992	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-amino-levulinate synthetase (ALA-S), cytoplasmic and mitochondrial rhodanese were determined in tumor (T) and liver of both normal mice (NM) and T-bearing mice (TBM).	Barbital	51-58	aminolevulinic acid synthase 1	Mus musculus	112-117
1526138-2	1992	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-amino-levulinate synthetase (ALA-S), cytoplasmic and mitochondrial rhodanese were determined in tumor (T) and liver of both normal mice (NM) and T-bearing mice (TBM).	Barbital	51-58	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	150-159
1554380-2	1992	Thus, following administration of PB (300, 500 ppm), barbital (BB, 1500 ppm) or 5-ethyl-5-phenylhydantoin (EPH, 500 ppm), CYP2B1-mediated benzyloxyresorufin O-dealkylase activity and epoxide hydrolase activity were profoundly induced in female DA and F344/NCr rats.	Barbital	53-61	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	122-128
1660669-2	1991	In veronal (5,5-diethybarbiturate) buffer, the luminescence is strongly quenched by ethanol and mannitol, but only weakly by t-butanol, benzoate and superoxide dismutase (SOD); complexing Fe2+ with 1,20-phenanthroline or 2,2"-dipyridyl causes a decrease of light production that can be partially obviated by the simultaneous addition of SOD.	Barbital	3-10	superoxide dismutase 1	Homo sapiens	149-169
1660669-2	1991	In veronal (5,5-diethybarbiturate) buffer, the luminescence is strongly quenched by ethanol and mannitol, but only weakly by t-butanol, benzoate and superoxide dismutase (SOD); complexing Fe2+ with 1,20-phenanthroline or 2,2"-dipyridyl causes a decrease of light production that can be partially obviated by the simultaneous addition of SOD.	Barbital	3-10	superoxide dismutase 1	Homo sapiens	171-174
1660669-2	1991	In veronal (5,5-diethybarbiturate) buffer, the luminescence is strongly quenched by ethanol and mannitol, but only weakly by t-butanol, benzoate and superoxide dismutase (SOD); complexing Fe2+ with 1,20-phenanthroline or 2,2"-dipyridyl causes a decrease of light production that can be partially obviated by the simultaneous addition of SOD.	Barbital	3-10	superoxide dismutase 1	Homo sapiens	337-340
2178097-3	1990	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM).	Barbital	51-58	aminolevulinic acid synthase 1	Mus musculus	77-109
2178097-3	1990	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM).	Barbital	51-58	aminolevulinic acid synthase 1	Mus musculus	111-116
2178097-3	1990	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM).	Barbital	51-58	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	119-135
2178097-3	1990	Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of delta-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM).	Barbital	51-58	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	137-146
2178097-12	1990	The induction level of cyt P-450 after veronal administration was nearly the same in liver of both TBM and NM.	Barbital	39-46	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	23-32
2498379-7	1989	The binding of T4 to apoA-I was reduced by known inhibitors of T4 binding to serum proteins (diclofenac = mefenamic acid = furosemide = 8-anilinonaphthalene sulfonic acid much greater than dilantin greater than heparin greater than barbital) and by lipids (unsaturated fatty acids greater than cholesterol = cholesterol esters = phospholipids greater than saturated fatty acids = diglycerides = triglycerides).	Barbital	232-240	apolipoprotein A1	Homo sapiens	21-27
7218379-9	1980	In the experiments using the above rats, the beta-glucuronidase activity in liver showed an increase by the administration of borneol, chloretone and barbital-Na.	Barbital	150-158	glucuronidase, beta	Rattus norvegicus	45-63
6121634-2	1982	All seven barbiturates induced ODC with barbital (7.7 fold increase) and phenobarbital (5.7 fold increase) demonstrating the most potent activity.	Barbital	40-48	ornithine decarboxylase 1	Rattus norvegicus	31-34
6121634-3	1982	Maximum induction of ODC by phenobarbital was obtained in 18 h. Barbital (500-5000 p.p.m.)	Barbital	64-72	ornithine decarboxylase 1	Rattus norvegicus	21-24
198505-4	1977	Its specific radioactivity was 5-12 mCi/ micro g. In assays, (0.05 M barbital buffer, 0.01% Triton X-100, pH 8.6) over 90% of (125)I-ApoA-II was bound by excess first antibody and over 95% was displaced by excess "cold" ApoA-II.	Barbital	69-77	apolipoprotein A2	Homo sapiens	133-140
37309-0	1979	Influence of the dopamine-beta-hydroxylase inhibitor FLA 63 on the disposition of barbitone in the mouse.	Barbital	82-91	dopamine beta hydroxylase	Mus musculus	17-42
149020-2	1978	Veronal-acetate pretreatment completely inhibited the ATPase reaction in these red fibres but not in type I fibres of the gastrocnemius.	Barbital	0-15	dynein axonemal heavy chain 8	Homo sapiens	54-60
913919-3	1977	It was found that: (1) phenobarbital, barbital, and thiopental, but not pentobarbital, significantly increased liver weight, cytochrome P-450 concentration in the liver, decreased pentobarbital sleeping time and induced a hypertrophy of the smooth endoplasmic reticulum in the hepatocytes at electron microscopy; (2) in contrast, the four barbiturates, including pentobarbital, significantly increased bile flow; this increase was attributed to an increase in the bile acid independent bile flow.	Barbital	28-36	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
241786-6	1975	Barbitone is an effective inducer of the drug-metabolizing enzymes, yet does not interact spectrally with cytochrome P-450; this is in accord with the observations that although there are increases in NADPH-cytochrome c reductase and cytochrome b5, following administration of barbitone there is no increase in cytochrome P-450.	Barbital	0-9	cytochrome b5 type A	Rattus norvegicus	234-247
241786-6	1975	Barbitone is an effective inducer of the drug-metabolizing enzymes, yet does not interact spectrally with cytochrome P-450; this is in accord with the observations that although there are increases in NADPH-cytochrome c reductase and cytochrome b5, following administration of barbitone there is no increase in cytochrome P-450.	Barbital	0-9	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	311-327
6029829-4	1967	The purified lipase was homogeneous over a BioGel 300 column and showed a single peak on electrophoresis in a Veronal buffer (pH 8.6, Gamma/2 = 0.1).	Barbital	110-117	lipase	Staphylococcus aureus	13-19